# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- RhoGEF PF00621.18 001162383.1_26229001_2 - 9.9e-30 104.0 0.3 1.8e-29 103.2 0.3 1.4 1 0 0 1 1 1 1 RhoGEF domain C1_1 PF00130.20 001162383.1_26229001_2 - 1.5e-05 24.6 3.7 3.1e-05 23.6 3.7 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.27 001162383.1_26229001_2 - 0.00018 21.9 0.0 0.00036 20.9 0.0 1.5 1 0 0 1 1 1 1 PH domain C1_2 PF03107.14 001162383.1_26229001_2 - 0.00038 20.6 1.4 0.00086 19.4 1.4 1.6 1 0 0 1 1 1 1 C1 domain Prok-RING_1 PF14446.4 001162383.1_26229001_2 - 0.0038 17.0 5.4 0.0078 16.0 5.4 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 zinc_ribbon_9 PF14369.4 001162383.1_26229001_2 - 0.075 13.2 0.9 0.3 11.2 0.9 2.0 1 0 0 1 1 1 0 zinc-ribbon PHD PF00628.27 001162383.1_26229001_2 - 0.34 10.7 6.5 0.76 9.6 6.5 1.6 1 0 0 1 1 1 0 PHD-finger Zf_RING PF16744.3 001162383.1_26229001_2 - 0.46 10.5 3.3 1.2 9.2 3.3 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger UDPGT PF00201.16 001082240.1_37924001_3 - 2.2e-262 871.1 0.1 2.6e-262 870.8 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001082240.1_37924001_3 - 8.7e-07 28.9 0.0 1.4e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Pro_3_hydrox_C PF05373.9 001082240.1_37924001_3 - 0.025 14.5 0.0 0.08 12.9 0.0 1.8 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal Cobalamin_bind PF01122.17 001130458.1_32925001_3 - 8.1e-115 382.9 0.0 1.1e-114 382.5 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic cobalamin-binding protein DUF4430 PF14478.4 001130458.1_32925001_3 - 3.4e-06 27.4 0.0 5.4e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4430) Rubredoxin PF00301.18 001082238.1_37923001_2 - 1.7 8.6 4.9 0.67 9.9 0.9 2.3 3 0 0 3 3 3 0 Rubredoxin Glycolytic PF00274.17 001082238.1_37923001_3 - 9.2e-189 626.3 0.0 1.1e-188 626.1 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I ETF_QO PF05187.11 001281737.1_26225001_3 - 1.1e-48 163.5 0.0 1.7e-48 162.9 0.0 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Thi4 PF01946.15 001281737.1_26225001_3 - 3.3e-08 32.9 0.0 3.1e-06 26.5 0.1 2.1 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.22 001281737.1_26225001_3 - 5.8e-08 32.1 1.1 0.00013 21.0 2.0 2.1 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.22 001281737.1_26225001_3 - 3.2e-07 30.2 0.3 0.00011 21.9 0.3 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.4 001281737.1_26225001_3 - 6e-07 29.5 0.1 3.3e-06 27.1 0.2 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.10 001281737.1_26225001_3 - 2.3e-05 23.5 0.1 3.2e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.12 001281737.1_26225001_3 - 2.7e-05 23.4 0.1 3.6e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.17 001281737.1_26225001_3 - 0.00027 20.2 0.8 0.00052 19.3 0.3 1.6 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.4 001281737.1_26225001_3 - 0.00042 20.2 0.2 0.00095 19.1 0.2 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding HI0933_like PF03486.12 001281737.1_26225001_3 - 0.00059 18.5 0.9 0.00083 18.0 0.9 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.25 001281737.1_26225001_3 - 0.0012 19.2 0.1 2.5 8.6 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001281737.1_26225001_3 - 0.006 15.7 0.3 0.0091 15.1 0.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.5 001281737.1_26225001_3 - 0.0087 15.3 0.5 0.013 14.8 0.5 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Fer4_7 PF12838.5 001281737.1_26225001_3 - 0.011 16.2 0.6 0.023 15.2 0.6 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Trp_halogenase PF04820.12 001281737.1_26225001_3 - 0.016 13.9 0.4 0.043 12.5 0.2 1.7 2 0 0 2 2 2 0 Tryptophan halogenase GIDA PF01134.20 001281737.1_26225001_3 - 0.12 11.3 0.6 0.18 10.7 0.6 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.19 001281737.1_26225001_3 - 0.13 11.4 0.2 0.21 10.7 0.2 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.4 001281737.1_26225001_3 - 0.15 11.0 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Mito_carr PF00153.25 001287673.1_29524001_1 - 6.8e-71 234.1 2.1 4.6e-24 84.0 0.0 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein ETRAMP PF09716.8 001285415.1_45725001_2 - 0.0016 18.3 0.2 0.0022 17.9 0.2 1.3 1 0 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) SR-25 PF10500.7 001285415.1_45725001_2 - 3.8 6.9 24.4 5.6 6.4 24.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein P2X_receptor PF00864.17 001285415.1_45725001_3 - 2.1e-134 448.1 0.9 1.2e-69 235.0 0.1 2.1 1 1 1 2 2 2 2 ATP P2X receptor Cornifin PF02389.13 001204427.1_32923001_2 - 8.2e-53 178.1 60.2 4.5e-32 110.9 27.8 2.9 2 1 1 3 3 3 2 Cornifin (SPRR) family DUF4774 PF15999.3 001204427.1_32923001_2 - 0.018 14.6 3.6 11 5.8 0.1 4.1 1 1 4 5 5 5 0 Domain of unknown function (DUF4774) E1-E2_ATPase PF00122.18 001114532.2_21027001_1 - 7.2e-58 195.4 2.1 7.2e-58 195.4 2.1 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 001114532.2_21027001_1 - 5.6e-44 149.9 0.3 5.6e-44 149.9 0.3 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 001114532.2_21027001_1 - 1.2e-23 82.9 0.0 2.6e-23 81.8 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 001114532.2_21027001_1 - 7.6e-19 68.7 0.1 1.2e-09 38.6 0.0 2.9 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 001114532.2_21027001_1 - 3.8e-18 64.8 0.0 7e-18 63.9 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 001114532.2_21027001_1 - 7.2e-06 25.8 1.1 0.00081 19.1 0.5 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Zona_pellucida PF00100.21 001270480.1_37924001_1 - 6.9e-45 153.7 0.0 1.1e-44 153.0 0.0 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain Trefoil PF00088.16 001270480.1_37924001_1 - 0.00011 21.8 6.8 0.00011 21.8 6.8 2.2 2 0 0 2 2 2 1 Trefoil (P-type) domain Fer4_15 PF13459.4 001270480.1_37924001_1 - 3.1 8.5 5.3 0.8 10.3 0.1 2.3 2 0 0 2 2 2 0 4Fe-4S single cluster domain Gastrin PF00918.15 214237.2_49822001_2 - 3.1e-39 134.7 0.0 5.4e-39 133.9 0.0 1.4 1 0 0 1 1 1 1 Gastrin/cholecystokinin family GDA1_CD39 PF01150.15 001281951.1_31324001_2 - 3.9e-76 256.3 0.0 1.4e-75 254.5 0.0 1.8 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family CEP19 PF14933.4 138865.2_45724001_1 - 7.7e-55 185.6 2.2 1.1e-54 185.0 2.2 1.3 1 0 0 1 1 1 1 CEP19-like protein Endothelin PF00322.15 001081823.2_21023001_3 - 4.3e-23 80.4 16.0 3.3e-20 71.2 6.4 2.4 2 0 0 2 2 2 2 Endothelin family DAP3 PF10236.7 004632.3_26225001_2 - 1.6e-92 309.9 0.0 2e-92 309.6 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_25 PF13481.4 004632.3_26225001_2 - 0.11 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.20 004632.3_26225001_2 - 0.15 12.3 0.0 0.27 11.5 0.0 1.4 1 0 0 1 1 1 0 RNA helicase ATP-gua_Ptrans PF00217.17 009897.2_32924001_3 - 1.2e-95 319.6 0.0 1.5e-95 319.3 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 009897.2_32924001_3 - 2.3e-31 107.9 0.0 3.6e-31 107.2 0.0 1.3 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain Ribosomal_L10 PF00466.18 148887.2_26224001_3 - 9.1e-07 28.8 0.1 1.5e-06 28.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 zf-C4 PF00105.16 001173004.1_09925001_1 - 4.7e-28 97.3 16.1 9.7e-28 96.3 16.1 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001173004.1_09925001_1 - 5.8e-15 55.3 0.3 1.1e-14 54.4 0.3 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor LIM PF00412.20 023063.4_32929001_3 - 1.2e-11 44.5 5.1 2.5e-11 43.5 5.1 1.6 1 0 0 1 1 1 1 LIM domain NGF PF00243.16 001277055.1_45723001_3 - 1.2e-50 170.3 3.4 1.7e-50 169.8 3.4 1.2 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.3 001277055.1_45723001_3 - 0.0011 19.2 0.5 0.0017 18.7 0.5 1.2 1 0 0 1 1 1 1 Spaetzle Peptidase_M28 PF04389.15 001283942.1_29525001_3 - 3.1e-47 160.7 0.0 3.9e-47 160.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 TIR PF01582.18 001256899.1_21026001_1 - 1.5e-23 83.4 1.1 2.7e-23 82.5 1.1 1.4 1 0 0 1 1 1 1 TIR domain LRR_8 PF13855.4 001256899.1_21026001_1 - 5.9e-17 61.0 45.1 1.2e-09 37.6 4.2 7.9 4 3 4 8 8 8 7 Leucine rich repeat LRR_4 PF12799.5 001256899.1_21026001_1 - 4e-16 58.7 49.5 0.00022 21.4 2.0 9.4 5 3 4 10 10 10 6 Leucine Rich repeats (2 copies) TIR_2 PF13676.4 001256899.1_21026001_1 - 9.9e-12 45.0 0.0 1.9e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 TIR domain LRRCT PF01463.22 001256899.1_21026001_1 - 0.00014 22.0 0.0 0.00062 20.0 0.0 2.3 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain LRR_9 PF14580.4 001256899.1_21026001_1 - 0.00024 20.5 9.2 0.19 11.1 0.5 3.6 3 0 0 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.4 001256899.1_21026001_1 - 0.1 12.6 33.5 1.5 8.9 0.1 9.9 11 0 0 11 11 11 0 Leucine Rich repeat TIR-like PF10137.7 001256899.1_21026001_1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain LRR_1 PF00560.31 001256899.1_21026001_1 - 0.34 11.4 37.5 7.6 7.3 0.1 10.9 9 2 1 10 10 10 0 Leucine Rich Repeat 6PF2K PF01591.16 001271063.1_45724001_2 - 1.6e-104 347.9 0.5 5.5e-104 346.2 0.4 1.8 2 0 0 2 2 2 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.20 001271063.1_45724001_2 - 2.9e-43 147.7 0.0 3.9e-43 147.3 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.4 001271063.1_45724001_2 - 1.6e-09 37.9 0.0 3.4e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.10 001271063.1_45724001_2 - 0.00023 20.4 0.0 0.00048 19.4 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin KTI12 PF08433.8 001271063.1_45724001_2 - 0.00041 19.8 0.1 0.00073 18.9 0.1 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 IL8 PF00048.18 213862.2_49822001_2 - 3.2e-13 49.5 0.7 5e-13 48.8 0.7 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like DUF3399 PF11879.6 001270962.1_45729001_3 - 1.8e-42 143.8 6.5 3.7e-42 142.7 6.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3399) Ion_trans PF00520.29 001270962.1_45729001_3 - 2.1e-42 144.9 14.3 3.2e-42 144.3 14.3 1.3 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001270962.1_45729001_3 - 4.1e-28 97.4 0.1 8.3e-28 96.5 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain Shal-type PF11601.6 001270962.1_45729001_3 - 6.8e-14 51.0 12.0 1.2e-13 50.1 12.0 1.4 1 0 0 1 1 1 1 Shal-type voltage-gated potassium channels, N-terminal Ion_trans_2 PF07885.14 001270962.1_45729001_3 - 1.8e-12 46.9 5.9 1.8e-12 46.9 5.9 2.2 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.3 001270962.1_45729001_3 - 0.00034 20.5 0.0 0.001 19.0 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain PKD_channel PF08016.10 001270962.1_45729001_3 - 0.02 13.5 8.5 0.03 12.9 8.5 1.2 1 0 0 1 1 1 0 Polycystin cation channel DAGK_cat PF00781.22 203280.3_32928001_2 - 4.1e-27 94.1 0.0 5.9e-27 93.6 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain tRNA-synt_2 PF00152.18 053799.3_45725001_3 - 6.9e-79 265.0 0.1 1.1e-78 264.4 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.23 053799.3_45725001_3 - 7.5e-09 35.3 1.1 1.3e-08 34.6 1.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.18 053799.3_45725001_3 - 0.00011 21.6 0.2 0.45 9.8 0.1 2.5 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) S-AdoMet_synt_N PF00438.18 053799.3_45725001_3 - 0.028 14.9 0.2 0.083 13.4 0.2 1.7 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, N-terminal domain BTB PF00651.29 001257123.1_21025001_1 - 9.5e-25 86.9 0.1 3e-24 85.3 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.13 001257123.1_21025001_1 - 3.2e-17 62.4 1.8 3.7e-17 62.2 0.4 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_1 PF01344.23 001257123.1_21025001_1 - 1.5e-13 49.9 15.7 1.1e-07 31.2 0.1 7.4 6 2 1 7 7 7 3 Kelch motif Kelch_6 PF13964.4 001257123.1_21025001_1 - 4.6e-11 42.4 5.6 9.7e-06 25.6 0.0 5.5 2 2 2 4 4 4 2 Kelch motif Kelch_3 PF13415.4 001257123.1_21025001_1 - 8.7e-11 41.7 0.6 0.0014 18.7 0.0 5.8 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_4 PF13418.4 001257123.1_21025001_1 - 8.8e-09 35.1 0.0 0.02 14.7 0.0 3.9 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.13 001257123.1_21025001_1 - 3.7e-05 23.4 1.7 0.031 14.1 0.0 4.9 5 1 0 5 5 5 1 Kelch motif DUF3342 PF11822.6 001257123.1_21025001_1 - 0.00089 19.3 0.0 0.0016 18.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Spin-Ssty PF02513.15 011462.3_32929001_1 - 2e-73 241.8 6.6 3.5e-26 90.5 0.1 3.5 3 0 0 3 3 3 3 Spin/Ssty Family RCC1 PF00415.16 001205992.2_06526001_1 - 3.7e-35 120.2 13.4 1.6e-13 50.9 0.3 5.0 4 1 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 001205992.2_06526001_1 - 1.2e-23 82.2 13.0 1.9e-09 37.0 0.2 4.6 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat GBP PF02263.17 178050.4_32927001_3 - 1.6e-83 279.8 0.0 2.2e-83 279.4 0.0 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.12 178050.4_32927001_3 - 3.1e-05 23.4 0.1 5.3e-05 22.6 0.1 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Gp_dh_C PF02800.18 001206359.1_49823001_2 - 8e-70 233.4 0.0 1.3e-69 232.7 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.22 001206359.1_49823001_2 - 6.4e-39 132.3 0.3 1.5e-38 131.1 0.3 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.18 001206359.1_49823001_2 - 0.083 12.9 0.1 0.23 11.4 0.1 1.8 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Gastrin PF00918.15 001082510.2_21021001_3 - 6.3e-05 23.8 2.0 6.3e-05 23.8 2.0 2.0 1 1 1 2 2 2 1 Gastrin/cholecystokinin family UDPGT PF00201.16 001283275.1_29526001_1 - 1.4e-260 865.2 0.5 1.7e-260 864.9 0.5 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001283275.1_29526001_1 - 9.3e-07 28.8 0.0 1.7e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 001283275.1_29526001_1 - 0.00095 19.1 0.0 0.0053 16.6 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.4 001283275.1_29526001_1 - 0.05 13.9 0.0 0.11 12.8 0.0 1.5 1 1 0 1 1 1 0 Glycosyl transferase 4-like domain Nfu_N PF08712.9 001283275.1_29526001_1 - 0.073 13.0 0.1 8 6.4 0.0 2.6 2 0 0 2 2 2 0 Scaffold protein Nfu/NifU N terminal MT-A70 PF05063.12 001283275.1_29526001_3 - 2.4e-26 92.5 0.0 3.2e-26 92.2 0.0 1.1 1 0 0 1 1 1 1 MT-A70 Exo_endo_phos PF03372.21 001082514.2_21023001_3 - 1.3e-05 25.3 0.0 1.8e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Arf PF00025.19 026823.2_32924001_1 - 4.8e-45 153.0 0.2 6.6e-45 152.6 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 026823.2_32924001_1 - 1.5e-17 63.5 0.0 2e-17 63.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 026823.2_32924001_1 - 9e-16 58.1 0.0 1.3e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.10 026823.2_32924001_1 - 5e-09 35.7 0.0 7e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 026823.2_32924001_1 - 9.7e-08 31.5 0.0 1.3e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 026823.2_32924001_1 - 1.8e-06 27.2 0.1 0.00037 19.6 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.21 026823.2_32924001_1 - 4.6e-05 23.3 0.0 8.8e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ribosomal_L15e PF00827.15 001244065.1_49824001_3 - 5.5e-97 322.9 3.4 7.3e-97 322.5 3.4 1.1 1 0 0 1 1 1 1 Ribosomal L15 Trypsin PF00089.24 214000.2_49823001_3 - 1.3e-54 185.2 0.1 1.7e-54 184.8 0.1 1.2 1 0 0 1 1 1 1 Trypsin IL5 PF02025.13 001172970.1_09922001_1 - 1.1e-61 205.8 2.6 1.4e-61 205.5 2.6 1.1 1 0 0 1 1 1 1 Interleukin 5 TPR_1 PF00515.26 001289505.2_32929001_1 - 1.7e-22 78.1 0.0 4.9e-05 22.8 0.0 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.15 001289505.2_32929001_1 - 5.1e-19 66.7 2.3 0.00063 19.5 0.0 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.4 001289505.2_32929001_1 - 9.3e-16 56.5 0.4 0.0061 16.6 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.4 001289505.2_32929001_1 - 2.3e-12 46.2 0.6 0.0043 16.6 0.0 4.8 3 2 2 5 5 5 3 TPR repeat TPR_17 PF13431.4 001289505.2_32929001_1 - 3.5e-11 42.5 3.9 0.19 12.0 0.4 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.4 001289505.2_32929001_1 - 9.1e-11 41.5 3.6 0.0085 16.7 0.5 5.3 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.4 001289505.2_32929001_1 - 3e-10 40.3 4.0 0.0033 17.8 1.6 4.2 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.4 001289505.2_32929001_1 - 8.2e-10 38.6 1.1 0.0035 17.4 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.4 001289505.2_32929001_1 - 5.6e-09 36.4 4.4 1.3e-05 25.6 0.2 3.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.4 001289505.2_32929001_1 - 4e-08 33.3 2.8 2.2 8.5 0.0 4.2 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.4 001289505.2_32929001_1 - 5.2e-07 29.8 1.8 0.0013 18.8 0.4 3.6 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.4 001289505.2_32929001_1 - 9.4e-06 25.2 0.8 2.4 8.2 0.1 4.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.4 001289505.2_32929001_1 - 5e-05 23.5 0.5 34 5.3 0.0 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.5 001289505.2_32929001_1 - 8.5e-05 22.6 2.1 0.23 11.6 1.6 2.9 2 1 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF4248 PF14053.4 001289505.2_32929001_1 - 0.036 14.0 0.1 0.089 12.7 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) SHNi-TPR PF10516.7 001289505.2_32929001_1 - 0.19 11.1 5.2 25 4.3 0.8 3.5 3 0 0 3 3 3 0 SHNi-TPR Mo25 PF08569.9 001287339.1_26227001_3 - 2.8e-137 457.3 13.0 3.5e-137 457.0 13.0 1.1 1 0 0 1 1 1 1 Mo25-like Dysbindin PF04440.14 025772.4_32923001_2 - 2.6e-62 209.2 9.2 6.1e-62 207.9 9.2 1.7 1 0 0 1 1 1 1 Dysbindin (Dystrobrevin binding protein 1) DUF2730 PF10805.6 025772.4_32923001_2 - 0.023 14.7 0.2 0.023 14.7 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Peptidase_S46 PF10459.7 025772.4_32923001_2 - 0.044 12.3 5.6 0.053 12.0 5.6 1.1 1 0 0 1 1 1 0 Peptidase S46 APG6 PF04111.10 025772.4_32923001_2 - 0.3 10.3 11.5 0.54 9.5 11.5 1.5 1 0 0 1 1 1 0 Autophagy protein Apg6 FUSC PF04632.10 025772.4_32923001_2 - 4.7 5.5 12.7 26 3.0 13.1 1.9 1 1 0 1 1 1 0 Fusaric acid resistance protein family DUF342 PF03961.11 025772.4_32923001_2 - 4.8 5.5 5.7 8 4.8 5.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) SapB_1 PF05184.13 001190238.1_45726001_3 - 3.6e-43 145.0 19.0 7.4e-14 51.3 1.0 4.8 4 0 0 4 4 4 4 Saposin-like type B, region 1 SapB_2 PF03489.15 001190238.1_45726001_3 - 8.6e-39 131.2 25.4 7.9e-11 41.7 3.8 5.9 5 0 0 5 5 5 4 Saposin-like type B, region 2 SapA PF02199.13 001190238.1_45726001_3 - 1.8e-28 98.3 23.5 1.6e-16 60.0 9.2 4.4 4 0 0 4 4 4 2 Saposin A-type domain CYSTM PF12734.5 001190238.1_45726001_3 - 0.67 10.2 4.7 4.8 7.5 0.8 2.7 2 0 0 2 2 2 0 Cysteine-rich TM module stress tolerance DUF4451 PF14616.4 001190238.1_45726001_3 - 2 8.5 5.2 44 4.2 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4451) N6-adenineMlase PF10237.7 030185.3_32929001_1 - 5.2e-20 71.7 0.0 8.9e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase zf-GRF PF06839.10 030185.3_32929001_1 - 6.5e-16 58.0 2.9 2.9e-15 55.9 2.9 2.2 1 0 0 1 1 1 1 GRF zinc finger BRCT PF00533.24 030185.3_32929001_1 - 0.1 12.9 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain FGF PF00167.16 006119.4_26222001_1 - 6.3e-42 142.5 0.5 9.7e-42 141.9 0.5 1.3 1 0 0 1 1 1 1 Fibroblast growth factor Ank_2 PF12796.5 001109686.2_32929001_3 - 4.2e-46 155.3 1.3 1.4e-15 57.5 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001109686.2_32929001_3 - 1.8e-40 136.7 6.1 1.9e-12 47.3 0.0 5.6 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 001109686.2_32929001_3 - 1.1e-33 111.3 3.3 2e-05 24.5 0.0 8.2 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.4 001109686.2_32929001_3 - 8.7e-33 111.7 6.5 1.2e-10 41.3 0.0 6.2 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.28 001109686.2_32929001_3 - 5.1e-32 108.8 3.4 4.9e-05 23.5 0.0 7.4 7 0 0 7 7 7 6 Ankyrin repeat SET PF00856.26 001109686.2_32929001_3 - 1.3e-21 77.5 0.0 1.3e-21 77.5 0.0 3.6 3 1 0 3 3 3 1 SET domain Pre-SET PF05033.14 001109686.2_32929001_3 - 4.9e-16 59.2 13.3 4.9e-16 59.2 13.3 3.8 5 0 0 5 5 5 1 Pre-SET motif Sec7 PF01369.18 001277056.1_45729001_1 - 8.4e-69 230.8 0.5 1.9e-68 229.6 0.5 1.7 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.5 001277056.1_45729001_1 - 1.8e-50 170.9 3.6 1.8e-50 170.9 3.6 3.4 5 0 0 5 5 5 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.3 001277056.1_45729001_1 - 1.9e-42 144.8 0.2 1.9e-42 144.8 0.2 3.2 4 0 0 4 4 4 1 Dimerisation and cyclophilin-binding domain of Mon2 DUF1981 PF09324.8 001277056.1_45729001_1 - 1.1e-35 121.2 0.2 1.1e-35 121.2 0.2 4.5 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) UDPGT PF00201.16 001171014.1_37924001_3 - 2.9e-262 870.7 0.1 3.6e-262 870.4 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001171014.1_37924001_3 - 3.3e-06 27.1 0.0 5.7e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_4_2 PF13477.4 001171014.1_37924001_3 - 0.0038 17.1 0.0 0.38 10.7 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase 4-like Glyco_transf_4 PF13439.4 001171014.1_37924001_3 - 0.031 14.2 0.0 0.6 9.9 0.0 2.5 1 1 0 1 1 1 0 Glycosyltransferase Family 4 Glyco_trans_1_3 PF13528.4 001171014.1_37924001_3 - 0.047 12.8 0.0 1.6 7.8 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 1 Pro_3_hydrox_C PF05373.9 001171014.1_37924001_3 - 0.075 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal Glyco_trans_4_4 PF13579.4 001171014.1_37924001_3 - 0.16 12.3 0.0 0.55 10.5 0.0 1.8 1 1 0 1 1 1 0 Glycosyl transferase 4-like domain UDPGT PF00201.16 001171016.2_37926001_1 - 1.1e-251 835.8 0.6 1.4e-251 835.5 0.6 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001171016.2_37926001_1 - 5.6e-06 26.3 0.0 9.8e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Pro_3_hydrox_C PF05373.9 001171016.2_37926001_1 - 0.064 13.2 0.7 0.62 10.1 0.0 2.5 2 0 0 2 2 2 0 L-proline 3-hydroxylase, C-terminal TBP-binding PF09247.9 001171016.2_37926001_2 - 0.19 11.9 1.2 0.44 10.7 0.1 2.1 2 0 0 2 2 2 0 TATA box-binding protein binding PrmA PF06325.11 001252095.1_32924001_2 - 1.3e-10 41.0 0.1 2e-10 40.5 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.7 001252095.1_32924001_2 - 6.3e-08 32.4 0.0 1.3e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.12 001252095.1_32924001_2 - 8.6e-06 25.3 0.0 1.3e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.14 001252095.1_32924001_2 - 0.00085 19.0 0.0 0.0014 18.3 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.4 001252095.1_32924001_2 - 0.0047 16.7 0.0 0.011 15.5 0.0 1.5 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.4 001252095.1_32924001_2 - 0.017 15.7 0.0 0.027 15.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.4 001252095.1_32924001_2 - 0.19 11.4 0.0 0.29 10.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DUF2992 PF11208.6 001281325.1_31324001_1 - 0.7 10.0 4.2 1.3 9.1 4.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) Oest_recep PF02159.13 001281325.1_31324001_2 - 1.4e-60 203.6 6.6 1.4e-60 203.6 6.6 1.9 2 0 0 2 2 2 1 Oestrogen receptor Hormone_recep PF00104.28 001281325.1_31324001_2 - 1.2e-34 119.6 2.5 2e-34 118.9 2.5 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001281325.1_31324001_2 - 1.7e-31 108.4 13.9 2.7e-31 107.7 13.9 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) ESR1_C PF12743.5 001281325.1_31324001_2 - 2e-21 75.3 5.7 3.9e-21 74.4 5.7 1.5 1 0 0 1 1 1 1 Oestrogen-type nuclear receptor final C-terminal tRNA-synt_2 PF00152.18 053092.3_32925001_3 - 1.4e-80 270.6 0.1 2e-80 270.1 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.23 053092.3_32925001_3 - 4e-15 55.4 0.0 1.3e-14 53.8 0.0 1.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.18 053092.3_32925001_3 - 1.3e-07 31.2 0.1 0.0064 15.9 0.0 2.5 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) HSP70 PF00012.18 053092.3_32925001_3 - 0.8 7.7 4.7 1.2 7.1 4.7 1.1 1 0 0 1 1 1 0 Hsp70 protein Smoothelin PF12510.6 001284428.1_32927001_2 - 2.3e-48 161.9 27.3 4.3e-21 74.5 0.8 3.9 4 0 0 4 4 4 3 Smoothelin cytoskeleton protein CH PF00307.29 001284428.1_32927001_2 - 3.8e-24 84.8 0.0 3.4e-22 78.5 0.0 2.5 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001284428.1_32927001_2 - 1.6e-05 24.5 0.0 3.1e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain Peptidase_M3_N PF08439.8 001284428.1_32927001_2 - 0.14 12.3 8.9 4.3 7.6 1.3 3.3 3 0 0 3 3 3 0 Oligopeptidase F UQ_con PF00179.24 001309219.1_21023001_2 - 3.8e-46 156.1 0.0 5.4e-46 155.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.4 001309219.1_21023001_2 - 0.029 13.9 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.20 001309219.1_21023001_2 - 0.038 14.1 0.1 0.068 13.3 0.1 1.4 1 0 0 1 1 1 0 RWD domain muHD PF10291.7 001285862.1_32929001_2 - 4.6e-71 239.2 0.0 6.2e-71 238.8 0.0 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain Adap_comp_sub PF00928.19 001285862.1_32929001_2 - 8.5e-07 28.5 0.0 2.3e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Adaptor complexes medium subunit family START PF01852.17 001081800.2_21026001_1 - 9.5e-53 178.6 0.0 1.4e-52 178.1 0.0 1.2 1 0 0 1 1 1 1 START domain Polyketide_cyc PF03364.18 001081800.2_21026001_1 - 0.06 13.4 0.0 0.16 12.0 0.0 1.7 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport Synapsin_C PF02750.12 001110782.2_45727001_3 - 3.3e-121 402.2 0.8 4.3e-121 401.8 0.8 1.1 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.14 001110782.2_45727001_3 - 1.1e-43 147.5 0.0 2.9e-43 146.1 0.0 1.7 2 0 0 2 2 2 1 Synapsin, N-terminal domain Synapsin_N PF10581.7 001110782.2_45727001_3 - 6.8e-21 73.8 6.5 1.9e-20 72.4 6.5 1.8 1 0 0 1 1 1 1 Synapsin N-terminal Galactosyl_T PF01762.19 001278650.1_26226001_1 - 4.6e-58 196.1 0.0 5.9e-58 195.8 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase PAS_11 PF14598.4 001081921.2_21026001_3 - 8.8e-26 90.1 0.2 4.7e-22 78.1 0.1 2.3 2 0 0 2 2 2 2 PAS domain PAS PF00989.23 001081921.2_21026001_3 - 1.4e-20 73.3 0.0 3.9e-09 36.4 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.10 001081921.2_21026001_3 - 1.2e-19 70.2 0.0 1.1e-11 44.7 0.0 2.4 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 001081921.2_21026001_3 - 2.7e-17 62.3 0.8 4.9e-17 61.5 0.8 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 001081921.2_21026001_3 - 2.5e-08 34.0 0.0 7e-05 22.9 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 001081921.2_21026001_3 - 5.3e-05 23.3 0.0 0.013 15.6 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_2 PF08446.9 001081921.2_21026001_3 - 0.039 14.5 0.0 0.13 12.8 0.0 1.8 2 0 0 2 2 2 0 PAS fold 7tm_1 PF00001.19 001081782.2_21025001_2 - 3e-87 292.1 0.0 3.7e-87 291.8 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001081782.2_21025001_2 - 5e-12 45.6 4.5 2.4e-07 30.3 1.5 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001081782.2_21025001_2 - 3.5e-05 23.5 7.0 0.00016 21.4 1.3 2.7 3 0 0 3 3 3 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001081782.2_21025001_2 - 8.2e-05 21.9 2.0 8.2e-05 21.9 2.0 1.9 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Pkinase PF00069.23 001081803.2_21025001_3 - 6.2e-75 251.8 0.0 8.3e-75 251.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001081803.2_21025001_3 - 1e-41 142.8 0.0 1.4e-41 142.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.3 001081803.2_21025001_3 - 6.3e-13 49.1 0.0 1.7e-12 47.7 0.0 1.7 1 0 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.4 001081803.2_21025001_3 - 3.4e-05 23.2 0.0 5.6e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 001081803.2_21025001_3 - 0.0039 16.7 0.2 0.0069 15.9 0.2 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.12 001081803.2_21025001_3 - 0.0075 15.5 0.1 0.014 14.6 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001081803.2_21025001_3 - 0.11 12.3 0.2 0.25 11.1 0.2 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family UDPGT PF00201.16 001173026.1_09926001_2 - 1.1e-231 769.9 0.1 1.3e-231 769.6 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001173026.1_09926001_2 - 0.00034 20.5 0.0 0.00057 19.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_4_2 PF13477.4 001173026.1_09926001_2 - 0.0056 16.6 0.0 0.4 10.6 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase 4-like Glyco_transf_4 PF13439.4 001173026.1_09926001_2 - 0.016 15.1 0.0 0.048 13.5 0.0 1.8 1 1 0 1 1 1 0 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.4 001173026.1_09926001_2 - 0.16 12.2 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain Dynamin_M PF01031.18 173096.3_45727001_3 - 1.9e-78 263.4 11.3 3.4e-78 262.6 11.3 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.21 173096.3_45727001_3 - 5.4e-49 166.3 0.2 5.4e-49 166.3 0.2 2.4 2 1 0 2 2 2 1 Dynamin family GED PF02212.16 173096.3_45727001_3 - 6.2e-22 77.4 1.0 1.9e-21 75.9 1.0 1.9 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.21 173096.3_45727001_3 - 0.00044 20.2 2.0 0.0012 18.7 0.4 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_21 PF13304.4 173096.3_45727001_3 - 0.029 14.1 0.8 0.042 13.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 173096.3_45727001_3 - 0.043 13.4 0.1 0.089 12.4 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Stathmin PF00836.17 001283053.1_26225001_3 - 9.2e-53 177.7 13.5 9.2e-53 177.7 13.5 2.3 2 0 0 2 2 2 1 Stathmin family NADH5_C PF06455.9 001283053.1_26225001_3 - 0.17 11.3 0.1 0.26 10.7 0.1 1.2 1 0 0 1 1 1 0 NADH dehydrogenase subunit 5 C-terminus Atg14 PF10186.7 001283053.1_26225001_3 - 0.38 9.7 10.9 0.61 9.0 10.9 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TIR PF01582.18 001257142.1_21025001_1 - 1e-25 90.4 0.6 1.9e-25 89.5 0.6 1.4 1 0 0 1 1 1 1 TIR domain LRR_8 PF13855.4 001257142.1_21025001_1 - 8.8e-23 79.7 27.8 1.9e-10 40.2 2.8 7.8 3 2 6 9 9 9 7 Leucine rich repeat LRR_4 PF12799.5 001257142.1_21025001_1 - 2.4e-18 65.7 37.2 9e-06 25.8 0.3 8.0 6 2 2 8 8 8 6 Leucine Rich repeats (2 copies) TIR_2 PF13676.4 001257142.1_21025001_1 - 6e-13 48.9 0.0 1.1e-12 48.0 0.0 1.4 1 0 0 1 1 1 1 TIR domain LRR_6 PF13516.4 001257142.1_21025001_1 - 5.4e-08 32.2 18.9 0.51 10.4 0.0 10.5 11 0 0 11 11 11 3 Leucine Rich repeat LRR_1 PF00560.31 001257142.1_21025001_1 - 1.6e-06 27.6 34.9 1.9 9.1 0.1 11.2 9 2 0 9 9 9 3 Leucine Rich Repeat LRR_9 PF14580.4 001257142.1_21025001_1 - 3e-06 26.7 12.0 0.0017 17.8 0.3 4.1 3 1 1 4 4 4 2 Leucine-rich repeat LRRCT PF01463.22 001257142.1_21025001_1 - 8.4e-05 22.7 0.0 0.00057 20.1 0.0 2.6 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain Stathmin PF00836.17 001270859.1_45723001_3 - 2.1e-53 179.8 13.5 3.5e-53 179.1 13.5 1.4 1 0 0 1 1 1 1 Stathmin family Pex19 PF04614.10 001270859.1_45723001_3 - 0.023 14.3 2.6 0.035 13.7 2.6 1.2 1 0 0 1 1 1 0 Pex19 protein family Atg14 PF10186.7 001270859.1_45723001_3 - 0.16 10.8 11.0 0.26 10.2 11.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 SLBP_RNA_bind PF15247.4 001246472.1_39724001_1 - 1.1e-28 99.0 4.1 1.1e-28 99.0 4.1 2.1 2 0 0 2 2 2 1 Histone RNA hairpin-binding protein RNA-binding domain DUF936 PF06075.10 001246472.1_39724001_1 - 0.67 8.7 6.1 0.79 8.5 6.1 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Stathmin PF00836.17 001270858.1_45723001_3 - 2.3e-53 179.7 13.5 3.4e-53 179.1 13.5 1.3 1 0 0 1 1 1 1 Stathmin family Pex19 PF04614.10 001270858.1_45723001_3 - 0.027 14.1 2.8 0.038 13.6 2.8 1.1 1 0 0 1 1 1 0 Pex19 protein family Atg14 PF10186.7 001270858.1_45723001_3 - 0.18 10.7 11.0 0.26 10.2 11.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Tcp10_C PF07202.11 001242545.1_21029001_2 - 5.1e-87 290.2 5.7 2.6e-86 287.9 5.7 2.4 1 0 0 1 1 1 1 T-complex protein 10 C-terminus Mito_carr PF00153.25 001324312.1_26225001_2 - 6.4e-57 189.3 5.0 1.5e-23 82.4 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.25 001324312.1_26225001_3 - 7e-09 35.4 0.1 1.1e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial carrier protein Sod_Cu PF00080.18 001190422.1_49822001_2 - 2.2e-48 163.9 4.3 2.7e-48 163.6 4.3 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Dynamin_M PF01031.18 001271059.1_45727001_3 - 1.8e-78 263.5 11.3 3.2e-78 262.7 11.3 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.21 001271059.1_45727001_3 - 5.2e-49 166.4 0.2 5.2e-49 166.4 0.2 2.5 2 1 0 2 2 2 1 Dynamin family GED PF02212.16 001271059.1_45727001_3 - 5.8e-22 77.5 1.0 1.8e-21 75.9 1.0 1.9 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.21 001271059.1_45727001_3 - 0.00039 20.4 2.0 0.0012 18.8 0.4 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_21 PF13304.4 001271059.1_45727001_3 - 0.027 14.2 0.8 0.04 13.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001271059.1_45727001_3 - 0.041 13.5 0.1 0.086 12.4 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain SapB_1 PF05184.13 013013.2_45726001_3 - 3.6e-43 145.0 19.0 7.4e-14 51.3 1.0 4.8 4 0 0 4 4 4 4 Saposin-like type B, region 1 SapB_2 PF03489.15 013013.2_45726001_3 - 8.6e-39 131.2 25.4 7.9e-11 41.7 3.8 5.9 5 0 0 5 5 5 4 Saposin-like type B, region 2 SapA PF02199.13 013013.2_45726001_3 - 1.8e-28 98.2 23.5 1.6e-16 60.0 9.2 4.4 4 0 0 4 4 4 2 Saposin A-type domain CYSTM PF12734.5 013013.2_45726001_3 - 0.67 10.2 4.7 4.8 7.5 0.8 2.8 2 0 0 2 2 2 0 Cysteine-rich TM module stress tolerance DUF4451 PF14616.4 013013.2_45726001_3 - 1.4 9.0 5.0 44 4.2 0.0 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4451) Hexokinase_2 PF03727.14 001033245.4_32927001_1 - 2.3e-148 492.0 0.0 2e-83 279.4 0.0 2.2 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.19 001033245.4_32927001_1 - 1.5e-130 432.9 0.0 5.7e-67 225.4 0.0 2.2 2 0 0 2 2 2 2 Hexokinase RIX1 PF08167.10 001033245.4_32927001_1 - 0.055 13.1 0.1 0.13 11.9 0.1 1.5 1 0 0 1 1 1 0 rRNA processing/ribosome biogenesis Lipocalin PF00061.21 001290249.1_22422001_2 - 5.9e-22 78.3 0.0 7.6e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.10 001290249.1_22422001_2 - 3.1e-06 27.1 0.0 4.7e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Lipocalin-like domain Triabin PF03973.11 001290249.1_22422001_2 - 0.018 14.8 0.3 0.041 13.6 0.3 1.6 1 1 0 1 1 1 0 Triabin PrmA PF06325.11 177101.5_32924001_3 - 1.2e-10 41.2 0.1 1.8e-10 40.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.7 177101.5_32924001_3 - 5.5e-08 32.6 0.0 1.1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.12 177101.5_32924001_3 - 7.8e-06 25.4 0.0 1.2e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.14 177101.5_32924001_3 - 0.00077 19.1 0.0 0.0013 18.4 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.4 177101.5_32924001_3 - 0.0041 16.9 0.0 0.0095 15.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 177101.5_32924001_3 - 0.015 15.9 0.0 0.025 15.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.4 177101.5_32924001_3 - 0.17 11.5 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain TRM PF02005.14 177101.5_32924001_3 - 0.18 10.8 0.0 0.25 10.3 0.0 1.1 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Nucleoside_tran PF01733.16 001199115.1_32925001_3 - 7.1e-127 422.9 2.4 7.1e-127 422.9 2.4 2.2 1 1 2 3 3 3 2 Nucleoside transporter Granin PF01271.15 001081814.2_21024001_1 - 4.7e-92 309.7 66.0 1.2e-69 235.7 60.8 2.1 1 1 1 2 2 2 2 Granin (chromogranin or secretogranin) BRCA-2_helical PF09169.8 009765.3_32929001_3 - 2e-91 304.6 0.0 5.7e-91 303.1 0.0 1.9 1 0 0 1 1 1 1 BRCA2, helical BRCA2 PF00634.16 009765.3_32929001_3 - 1.2e-78 258.0 27.7 1e-12 47.2 0.1 8.0 7 0 0 7 7 7 7 BRCA2 repeat BRCA-2_OB3 PF09104.8 009765.3_32929001_3 - 1e-46 157.9 0.0 3.1e-46 156.3 0.0 1.9 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 BRCA-2_OB1 PF09103.8 009765.3_32929001_3 - 9.3e-41 138.5 0.0 4.8e-40 136.2 0.0 2.4 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Tower PF09121.8 009765.3_32929001_3 - 3.7e-18 65.3 3.0 8.2e-18 64.2 3.0 1.6 1 0 0 1 1 1 1 Tower UDPGT PF00201.16 001195805.1_37926001_1 - 5.1e-221 734.6 0.0 6.7e-221 734.2 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001195805.1_37926001_1 - 3e-07 30.4 0.0 5.2e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain zf-NOSIP PF15906.3 001284556.1_29523001_3 - 1.2e-52 175.9 1.9 2.2e-52 175.0 1.9 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Rtf2 PF04641.10 001284556.1_29523001_3 - 2.3e-12 46.7 0.6 4.6e-05 22.8 0.0 2.7 2 1 1 3 3 3 2 Rtf2 RING-finger U-box PF04564.13 001284556.1_29523001_3 - 1.6e-08 34.5 0.3 0.0015 18.6 0.0 3.5 4 0 0 4 4 4 2 U-box domain zf-Nse PF11789.6 001284556.1_29523001_3 - 0.0026 17.4 0.6 0.03 14.0 0.1 2.5 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit GCR PF02155.13 001257250.2_08025001_1 - 3.6e-182 605.3 11.3 4.5e-182 605.0 11.3 1.1 1 0 0 1 1 1 1 Glucocorticoid receptor Hormone_recep PF00104.28 001257250.2_08025001_1 - 2.3e-30 105.6 6.8 2.4e-30 105.6 4.7 1.9 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001257250.2_08025001_1 - 2.8e-28 98.0 13.0 5.2e-28 97.2 13.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Methyltransf_16 PF10294.7 001289029.1_26225001_1 - 1.2e-17 64.1 0.0 2e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase FAM86 PF14904.4 001289029.1_26225001_1 - 2.7e-15 56.2 0.0 5.5e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 Family of unknown function MTS PF05175.12 001289029.1_26225001_1 - 0.055 12.9 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.4 001289029.1_26225001_1 - 0.17 12.5 0.0 0.35 11.5 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Alpha-amylase_C PF02806.16 001081940.2_21025001_1 - 1.2e-25 89.7 0.0 2.6e-25 88.5 0.0 1.6 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.16 001081940.2_21025001_1 - 1.7e-17 63.4 0.0 4e-17 62.2 0.0 1.7 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.22 001081940.2_21025001_1 - 9.1e-15 54.9 1.4 1.7e-12 47.4 0.0 2.8 1 1 2 3 3 3 2 Alpha amylase, catalytic domain hDGE_amylase PF14701.4 001081940.2_21025001_1 - 0.021 13.8 0.3 0.11 11.4 0.1 2.2 3 0 0 3 3 3 0 Glycogen debranching enzyme, glucanotransferase domain Hormone_1 PF00103.18 001304934.1_01322001_1 - 2.2e-80 269.3 0.2 2.5e-80 269.1 0.2 1.0 1 0 0 1 1 1 1 Somatotropin hormone family KIAA1430 PF13879.4 001304934.1_01322001_1 - 0.018 15.6 0.2 0.44 11.2 0.0 2.2 2 0 0 2 2 2 0 KIAA1430 homologue TB2_DP1_HVA22 PF03134.17 001281842.1_31324001_1 - 0.23 11.3 2.5 0.38 10.6 2.5 1.2 1 0 0 1 1 1 0 TB2/DP1, HVA22 family Peptidase_C14 PF00656.20 001281842.1_31324001_2 - 3.5e-56 190.8 0.1 4.5e-56 190.4 0.1 1.1 1 0 0 1 1 1 1 Caspase domain NR_Repeat PF14046.4 001194935.1_39724001_1 - 9.9e-103 336.0 30.5 1.9e-26 91.8 0.5 4.6 5 0 0 5 5 5 4 Nuclear receptor repeat Hormone_recep PF00104.28 001194935.1_39724001_1 - 3.9e-15 55.9 0.1 3e-14 53.0 0.1 2.0 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4_ClpX PF06689.11 001194935.1_39724001_1 - 4.2 7.2 13.3 7.4 6.4 0.6 3.4 3 0 0 3 3 3 0 ClpX C4-type zinc finger SapB_1 PF05184.13 001081929.3_21022001_1 - 7.9e-05 22.4 0.8 0.00012 21.9 0.0 1.7 2 0 0 2 2 2 1 Saposin-like type B, region 1 SapB_2 PF03489.15 001081929.3_21022001_1 - 0.00027 20.9 0.2 0.0012 18.7 0.3 2.1 2 0 0 2 2 2 1 Saposin-like type B, region 2 Ribosomal_L32p PF01783.21 001345883.1_40424001_1 - 0.16 12.1 4.9 0.9 9.7 0.2 2.4 2 0 0 2 2 2 0 Ribosomal L32p protein family APOBEC_N PF08210.9 001345883.1_40424001_2 - 9.8e-87 289.3 3.8 1.7e-44 151.7 0.1 2.1 2 0 0 2 2 2 2 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001345883.1_40424001_2 - 7e-62 205.2 0.1 1.8e-29 101.4 0.1 2.7 2 0 0 2 2 2 2 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001345883.1_40424001_2 - 0.0028 17.4 0.0 3 7.6 0.0 2.3 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region Toxin-deaminase PF14424.4 001345883.1_40424001_2 - 0.016 15.2 0.3 3.3 7.7 0.3 2.3 2 0 0 2 2 2 0 The BURPS668_1122 family of deaminases DUF3024 PF11225.6 001345883.1_40424001_2 - 0.03 14.4 0.0 11 6.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3024) Pox_A3L PF05288.9 001345883.1_40424001_2 - 0.12 12.3 0.2 4.7 7.1 0.0 2.9 2 1 0 2 2 2 0 Poxvirus A3L Protein NODP PF07684.10 001345883.1_40424001_2 - 1.1 9.3 4.8 0.86 9.6 1.2 2.1 2 0 0 2 2 2 0 NOTCH protein ATG13 PF10033.7 001346351.1_26229001_3 - 1.1e-12 48.0 0.0 6.5e-07 29.1 0.0 2.4 1 1 1 2 2 2 2 Autophagy-related protein 13 Myosin_head PF00063.19 213855.2_49829001_1 - 1.4e-293 975.2 2.9 1.4e-293 975.2 2.9 2.6 3 1 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 213855.2_49829001_1 - 5.8e-165 550.8 274.0 7.2e-165 550.5 274.0 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 213855.2_49829001_1 - 1.6e-13 50.0 5.3 4.1e-13 48.8 5.3 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 213855.2_49829001_1 - 3e-05 23.4 76.9 0.0077 15.5 4.3 9.1 1 1 9 11 11 11 8 Reovirus sigma C capsid protein IQ PF00612.25 213855.2_49829001_1 - 0.0079 15.8 1.4 0.12 12.1 0.2 2.7 2 0 0 2 2 2 1 IQ calmodulin-binding motif Filament PF00038.19 213855.2_49829001_1 - 0.078 12.4 233.5 0.004 16.7 58.8 7.8 1 1 4 6 6 6 0 Intermediate filament protein AAA_22 PF13401.4 213855.2_49829001_1 - 0.09 12.9 0.0 0.09 12.9 0.0 6.6 4 2 2 6 6 6 0 AAA domain FYVE PF01363.19 001359166.1_32929001_2 - 7.1e-28 96.4 29.8 1.9e-15 56.6 7.7 5.5 4 1 0 4 4 4 2 FYVE zinc finger AIG1 PF04548.14 001359166.1_32929001_2 - 0.0088 15.3 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 AIG1 family GBP PF02263.17 001359166.1_32929001_2 - 0.018 14.2 0.0 0.03 13.5 0.0 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain ATG13 PF10033.7 001346314.1_26229001_3 - 1.2e-12 47.8 0.0 9.9e-07 28.5 0.1 2.4 1 1 1 2 2 2 2 Autophagy-related protein 13 Glyoxalase PF00903.23 001348964.1_49823001_1 - 1.8e-24 86.2 0.6 3.6e-18 65.9 0.0 2.5 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.4 001348964.1_49823001_1 - 8.6e-12 45.2 0.1 0.00011 22.3 0.0 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.4 001348964.1_49823001_1 - 2.7e-06 27.5 0.0 0.008 16.2 0.0 2.8 3 0 0 3 3 3 2 Glyoxalase-like domain Glyoxalase_5 PF14696.4 001348964.1_49823001_1 - 0.023 14.7 0.0 0.068 13.2 0.0 1.7 2 0 0 2 2 2 0 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal ANTH PF07651.14 001357772.1_32929001_1 - 7.9e-84 280.8 0.3 1e-83 280.4 0.3 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.18 001357772.1_32929001_1 - 1.7e-14 53.8 0.0 2.8e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 ENTH domain VHS PF00790.17 001357772.1_32929001_1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 VHS domain COX17 PF05051.11 001357772.1_32929001_1 - 0.3 11.3 4.0 0.35 11.1 2.0 2.0 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) APOBEC_N PF08210.9 001345941.2_40425001_2 - 1.7e-101 337.3 13.3 5.3e-55 186.0 3.1 2.1 2 0 0 2 2 2 2 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001345941.2_40425001_2 - 6.2e-65 215.0 2.3 1.8e-32 110.9 0.1 2.5 2 0 0 2 2 2 2 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001345941.2_40425001_2 - 1.5e-06 27.9 0.1 0.049 13.4 0.0 2.3 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region Toxin-deaminase PF14424.4 001345941.2_40425001_2 - 0.00032 20.7 0.1 0.92 9.5 0.0 2.2 2 0 0 2 2 2 2 The BURPS668_1122 family of deaminases zf-H2C2_2 PF13465.4 001354750.1_26229001_2 - 1.1e-31 107.7 48.6 5.1e-07 29.7 1.4 10.1 9 0 0 9 9 9 7 Zinc-finger double domain BTB PF00651.29 001354750.1_26229001_2 - 2.6e-25 88.7 3.2 4.9e-25 87.8 3.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.4 001354750.1_26229001_2 - 4.4e-23 79.8 59.6 0.0007 20.1 1.8 10.5 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2 PF00096.24 001354750.1_26229001_2 - 5.5e-22 76.8 61.3 0.0011 19.2 2.6 10.0 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 001354750.1_26229001_2 - 1.9e-11 43.5 42.0 1e-05 25.2 0.2 8.8 8 0 0 8 8 8 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001354750.1_26229001_2 - 6.3e-09 35.8 36.2 0.00074 19.6 0.4 8.8 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001354750.1_26229001_2 - 4.7e-07 29.9 52.6 0.00022 21.4 1.1 9.6 9 0 0 9 9 9 4 Zinc-finger of C2H2 type ANTH PF07651.14 001357768.1_32929001_1 - 2.3e-77 259.6 1.1 3e-74 249.4 0.5 2.1 2 0 0 2 2 2 2 ANTH domain ENTH PF01417.18 001357768.1_32929001_1 - 1.3e-14 54.1 0.1 3.1e-14 53.0 0.0 1.6 2 0 0 2 2 2 1 ENTH domain VHS PF00790.17 001357768.1_32929001_1 - 0.14 11.8 0.0 0.23 11.2 0.0 1.2 1 0 0 1 1 1 0 VHS domain COX17 PF05051.11 001357768.1_32929001_1 - 0.34 11.2 4.0 0.37 11.0 2.0 2.0 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) DUF4540 PF15073.4 001347068.1_32924001_3 - 2.6e-63 211.9 5.9 5.6e-63 210.8 5.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4540) RWD PF05773.20 001260813.1_29626001_3 - 1.2e-23 83.5 0.0 2.7e-23 82.3 0.0 1.6 1 0 0 1 1 1 1 RWD domain IBR PF01485.19 001260813.1_29626001_3 - 8.8e-16 57.7 21.4 2.1e-11 43.7 3.9 4.5 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_5 PF14634.4 001260813.1_29626001_3 - 0.001 18.9 16.0 0.001 18.9 16.0 3.9 3 1 1 4 4 4 1 zinc-RING finger domain zf-RING_2 PF13639.4 001260813.1_29626001_3 - 0.01 15.9 11.8 0.01 15.9 11.8 4.5 3 1 1 4 4 4 0 Ring finger domain T5orf172 PF10544.7 001260813.1_29626001_3 - 0.023 15.1 0.0 0.15 12.5 0.0 2.1 2 0 0 2 2 2 0 T5orf172 domain zf-RING_11 PF17123.3 001260813.1_29626001_3 - 3 7.5 13.2 16 5.2 11.3 3.0 2 0 0 2 2 2 0 RING-like zinc finger Calcyon PF06387.9 001285058.1_29523001_1 - 5.2e-54 182.8 1.6 3.4e-32 111.7 0.1 2.1 1 1 1 2 2 2 2 D1 dopamine receptor-interacting protein (calcyon) DUF535 PF04393.11 001285058.1_29523001_1 - 0.16 11.0 0.0 0.23 10.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF535) B12D PF06522.9 001195008.2_21022001_2 - 4.2e-22 77.6 0.0 6.6e-22 76.9 0.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit RWD PF05773.20 001132418.1_43527001_3 - 3.5e-23 82.0 0.0 6.7e-23 81.1 0.0 1.5 1 0 0 1 1 1 1 RWD domain IBR PF01485.19 001132418.1_43527001_3 - 3.9e-15 55.7 20.9 1.9e-11 43.9 3.9 4.9 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_5 PF14634.4 001132418.1_43527001_3 - 0.001 18.8 16.0 0.001 18.8 16.0 4.4 3 1 1 4 4 4 1 zinc-RING finger domain zf-RING_2 PF13639.4 001132418.1_43527001_3 - 0.011 15.9 11.8 0.011 15.9 11.8 4.8 3 1 1 4 4 4 0 Ring finger domain T5orf172 PF10544.7 001132418.1_43527001_3 - 0.056 13.9 0.0 0.32 11.4 0.0 2.0 2 0 0 2 2 2 0 T5orf172 domain zf-RING_11 PF17123.3 001132418.1_43527001_3 - 2.6 7.7 13.2 17 5.1 11.3 3.1 2 0 0 2 2 2 0 RING-like zinc finger Ras PF00071.20 001193532.2_26225001_3 - 3.1e-45 153.6 0.0 4e-45 153.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001193532.2_26225001_3 - 4.1e-22 78.5 0.0 6.5e-22 77.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001193532.2_26225001_3 - 1.8e-11 43.7 0.0 2.7e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001193532.2_26225001_3 - 0.0011 18.8 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001193532.2_26225001_3 - 0.0036 16.5 0.0 0.0062 15.8 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001193532.2_26225001_3 - 0.032 13.5 0.0 0.047 13.0 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit LigB PF02900.16 001193532.2_26225001_3 - 0.076 11.9 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase IBR PF01485.19 001280136.1_39725001_2 - 3.3e-18 65.5 53.8 3.7e-13 49.4 6.2 4.6 4 0 0 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.23 001280136.1_39725001_2 - 0.0018 18.0 7.5 0.0018 18.0 7.5 4.8 5 1 0 5 5 5 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001280136.1_39725001_2 - 0.0019 17.8 9.4 0.0019 17.8 9.4 4.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001280136.1_39725001_2 - 2.1 8.5 54.7 0.048 13.8 10.0 5.0 4 0 0 4 4 4 0 Ring finger domain IBR PF01485.19 001013108.3_45729001_2 - 2.7e-19 69.0 47.1 1.8e-13 50.3 10.1 4.9 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.4 001013108.3_45729001_2 - 2.7e-05 23.8 2.9 2.7e-05 23.8 2.9 5.6 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001013108.3_45729001_2 - 0.0019 17.9 3.8 0.0019 17.9 3.8 6.1 5 1 1 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001013108.3_45729001_2 - 0.0024 17.7 6.1 0.0024 17.7 6.1 4.6 3 1 1 4 4 4 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 001013108.3_45729001_2 - 0.0038 17.1 4.1 0.0038 17.1 4.1 4.7 5 1 0 5 5 5 1 RING-type zinc-finger zf-RING_2 PF13639.4 001013108.3_45729001_2 - 0.0059 16.7 6.1 0.0059 16.7 6.1 6.2 3 1 1 4 4 4 1 Ring finger domain zf-C3HC4_4 PF15227.4 001013108.3_45729001_2 - 0.036 14.1 27.1 0.0099 15.9 5.1 4.9 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING Cwf_Cwc_15 PF04889.10 001013108.3_45729001_2 - 0.37 10.3 4.5 0.74 9.4 4.5 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CAF1A PF12253.6 001013108.3_45729001_2 - 0.67 10.0 10.1 1.3 9.1 10.1 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A Cupin_8 PF13621.4 001037196.1_45725001_1 - 1.2e-44 152.9 0.1 1.6e-44 152.5 0.1 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.10 001037196.1_45725001_1 - 4.8e-09 36.0 0.2 7.5e-09 35.3 0.2 1.3 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.20 001037196.1_45725001_1 - 0.0027 18.0 0.0 0.0064 16.8 0.0 1.6 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.9 001037196.1_45725001_1 - 0.016 14.8 0.0 0.091 12.4 0.0 2.2 2 1 0 2 2 2 0 Cupin domain DUF4712 PF15830.3 001100318.1_06523001_2 - 4.7e-140 465.4 0.4 5.5e-140 465.2 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4712) IBR PF01485.19 001106204.1_45724001_3 - 1.3e-14 54.1 25.5 9.6e-09 35.2 8.7 3.8 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain IncA PF04156.12 001106204.1_45724001_3 - 0.035 13.8 2.4 0.067 12.8 2.4 1.4 1 0 0 1 1 1 0 IncA protein DUF4516 PF14990.4 001135571.1_06522001_3 - 1.4e-24 85.4 0.6 2.2e-24 84.8 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4516) Ldl_recept_b PF00058.15 001280341.1_39726001_1 - 0.12 12.7 0.1 3.1 8.2 0.2 2.3 2 0 0 2 2 2 0 Low-density lipoprotein receptor repeat class B tRNA-synt_2b PF00587.23 001280341.1_39726001_2 - 1.7e-33 116.0 0.0 2.8e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.18 001280341.1_39726001_2 - 4.1e-19 68.4 0.1 7.4e-19 67.6 0.1 1.4 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.12 001280341.1_39726001_2 - 3.8e-09 36.4 0.0 9.8e-09 35.0 0.0 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.19 001280341.1_39726001_2 - 6e-09 35.7 0.0 1.2e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 TGS domain CholecysA-Rec_N PF09193.8 001265699.2_29625001_1 - 0.086 12.7 1.0 0.11 12.3 0.1 1.6 2 0 0 2 2 2 0 Cholecystokinin A receptor, N-terminal IBR PF01485.19 001265699.2_29625001_2 - 8.6e-17 61.0 25.3 1.4e-12 47.5 9.5 5.4 7 1 0 7 7 7 2 IBR domain, a half RING-finger domain IBR PF01485.19 001244645.1_39729001_2 - 3.3e-16 59.1 32.4 2.2e-13 50.0 10.1 5.9 4 1 1 5 5 5 2 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.4 001244645.1_39729001_2 - 3.3e-05 23.5 2.9 3.3e-05 23.5 2.9 5.6 5 1 1 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001244645.1_39729001_2 - 0.0023 17.7 3.8 0.0023 17.7 3.8 5.4 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001244645.1_39729001_2 - 0.0071 16.4 6.1 0.0071 16.4 6.1 5.6 4 1 1 5 5 5 1 Ring finger domain zf-C3HC4_4 PF15227.4 001244645.1_39729001_2 - 0.17 11.9 28.3 0.012 15.6 5.1 4.7 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING Cwf_Cwc_15 PF04889.10 001244645.1_39729001_2 - 0.18 11.4 2.4 0.34 10.5 2.4 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CAF1A PF12253.6 001244645.1_39729001_2 - 0.64 10.1 9.5 1.2 9.2 9.5 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A Ras PF00071.20 152304.2_26224001_1 - 8.4e-26 90.4 0.1 1.2e-25 89.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 152304.2_26224001_1 - 0.0011 19.1 0.0 0.0019 18.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 152304.2_26224001_1 - 0.0071 15.7 0.1 0.011 15.1 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family LigB PF02900.16 152304.2_26224001_1 - 0.075 12.0 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase C9orf72-like PF15019.4 001301184.1_21027001_3 - 3.6e-95 318.0 0.0 5.1e-95 317.5 0.0 1.2 1 0 0 1 1 1 1 C9orf72-like protein family 7tm_1 PF00001.19 001304737.1_45726001_2 - 2e-58 197.6 28.2 2.8e-58 197.1 28.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001304737.1_45726001_2 - 1.7e-08 34.0 26.8 2.7e-08 33.4 26.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001304737.1_45726001_2 - 5.3e-05 22.5 28.0 8.4e-05 21.9 28.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.19 001304736.1_45725001_1 - 1.5e-58 198.0 28.2 2.2e-58 197.5 28.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001304736.1_45725001_1 - 1.3e-08 34.4 26.9 2.1e-08 33.8 26.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001304736.1_45725001_1 - 4.2e-05 22.9 28.1 6.9e-05 22.2 28.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx zf-C2H2 PF00096.24 001098202.1_26227001_1 - 9.1e-24 82.4 22.9 1.6e-05 25.0 1.7 6.0 5 0 0 5 5 5 5 Zinc finger, C2H2 type BTB PF00651.29 001098202.1_26227001_1 - 1e-22 80.3 0.0 1.6e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.4 001098202.1_26227001_1 - 1.2e-19 69.2 25.9 0.00028 21.3 0.6 6.0 6 0 0 6 6 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001098202.1_26227001_1 - 2.2e-17 62.5 25.2 3.4e-07 30.3 0.1 6.3 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_jaz PF12171.6 001098202.1_26227001_1 - 1.4e-13 50.6 1.9 0.0013 18.8 0.2 5.4 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001098202.1_26227001_1 - 3.9e-09 36.1 17.7 0.034 14.0 0.2 5.9 5 1 0 5 5 5 3 C2H2-type zinc finger zf-met PF12874.5 001098202.1_26227001_1 - 1.1e-08 35.0 15.2 0.015 15.5 0.4 5.8 6 0 0 6 6 5 3 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 001098202.1_26227001_1 - 0.00028 20.5 15.7 0.27 10.9 0.3 5.0 5 0 0 5 5 5 2 zinc-finger C2H2-type zf-C2H2_2 PF12756.5 001098202.1_26227001_1 - 0.00034 20.8 11.8 2 8.7 7.6 4.9 2 1 2 4 4 4 2 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.10 001098202.1_26227001_1 - 0.0064 16.6 10.3 0.21 11.8 0.6 3.3 2 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-UBP PF02148.17 001098202.1_26227001_1 - 0.073 13.3 5.1 5.9 7.2 0.0 3.4 2 1 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein zf-C2H2_9 PF16293.3 001098202.1_26227001_1 - 0.13 12.0 0.6 22 4.8 0.0 3.3 2 1 1 3 3 3 0 C2H2 type zinc-finger (1 copy) LIM PF00412.20 001098202.1_26227001_1 - 0.25 11.5 5.8 0.38 10.9 0.3 3.0 1 1 2 3 3 3 0 LIM domain Zn-ribbon_8 PF09723.8 001098202.1_26227001_1 - 0.5 10.4 14.1 0.3 11.1 1.3 3.8 3 1 1 4 4 4 0 Zinc ribbon domain zinc_ribbon_15 PF17032.3 001098202.1_26227001_1 - 1.1 9.9 3.6 44 4.8 2.1 2.9 1 1 2 3 3 3 0 zinc-ribbon family C1_1 PF00130.20 001098202.1_26227001_1 - 1.2 8.9 3.8 1.9 8.3 0.2 2.9 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-AN1 PF01428.14 001098202.1_26227001_1 - 1.3 9.1 8.4 47 4.1 0.1 4.3 4 0 0 4 4 4 0 AN1-like Zinc finger HNH_5 PF14279.4 001098202.1_26227001_1 - 3.2 7.6 9.0 57 3.6 0.1 4.4 4 1 0 4 4 4 0 HNH endonuclease zf-LYAR PF08790.9 001098202.1_26227001_1 - 3.7 7.4 5.1 14 5.5 0.0 3.6 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger zf-BED PF02892.13 001098202.1_26227001_1 - 6.1 6.8 13.4 7 6.7 3.7 3.7 3 1 1 4 4 4 0 BED zinc finger SprT-like PF10263.7 001098202.1_26227001_1 - 9.7 5.9 11.7 4.5 7.0 1.2 2.5 2 1 0 3 3 2 0 SprT-like family 7tm_1 PF00001.19 031758.1_45723001_2 - 5.2e-44 150.3 19.1 6.7e-44 150.0 19.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 031758.1_45723001_2 - 1.2e-08 34.6 16.8 1.5e-08 34.2 16.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 031758.1_45723001_2 - 0.00061 19.0 8.8 0.00061 19.0 8.8 2.3 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 031758.1_45723001_2 - 0.8 9.3 15.9 4.9 6.7 15.9 1.9 1 1 0 1 1 1 0 Olfactory receptor TIMP PF00965.15 213857.1_49822001_1 - 2.7e-61 206.4 1.8 3.2e-61 206.2 1.8 1.0 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase Laminin_G_1 PF00054.21 001289114.1_26223001_2 - 1.2e-33 116.0 0.0 2.8e-31 108.3 0.0 2.3 2 0 0 2 2 2 2 Laminin G domain Laminin_G_2 PF02210.22 001289114.1_26223001_2 - 1.5e-16 61.0 0.0 6e-14 52.6 0.0 2.5 2 1 0 2 2 2 2 Laminin G domain Laminin_G_3 PF13385.4 001289114.1_26223001_2 - 0.0064 16.5 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF1080 PF06439.9 001289114.1_26223001_2 - 0.018 15.0 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) ECH_1 PF00378.18 024693.4_26224001_2 - 9.2e-53 179.0 0.0 1.1e-52 178.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 024693.4_26224001_2 - 8.1e-28 97.8 0.0 3.1e-27 95.9 0.0 1.8 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Laminin_G_1 PF00054.21 001146281.2_26222001_2 - 1.4e-31 109.3 0.0 1.9e-31 108.8 0.0 1.2 1 0 0 1 1 1 1 Laminin G domain Laminin_G_2 PF02210.22 001146281.2_26222001_2 - 2.6e-14 53.8 0.0 4.1e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.4 001146281.2_26222001_2 - 0.004 17.2 0.0 0.0086 16.1 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF1080 PF06439.9 001146281.2_26222001_2 - 0.013 15.5 0.0 0.02 14.9 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) Pax2_C PF12403.6 013992.3_26228001_1 - 5.4e-22 77.9 9.4 1.3e-21 76.6 9.4 1.7 1 0 0 1 1 1 1 Paired-box protein 2 C terminal PAX PF00292.16 013992.3_26228001_2 - 9.6e-72 238.7 0.4 1.4e-71 238.1 0.4 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.4 013992.3_26228001_2 - 0.00018 21.1 0.0 0.00037 20.1 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.4 013992.3_26228001_2 - 0.12 12.4 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain UPAR_LY6 PF00021.19 012925.1_45724001_3 - 3.9 8.1 22.1 0.061 13.9 11.3 2.9 2 1 0 2 2 2 0 u-PAR/Ly-6 domain 5_nucleotid_C PF02872.16 174129.3_06528001_1 - 1.3e-42 145.5 0.0 2e-42 144.9 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.26 174129.3_06528001_1 - 5.1e-12 46.6 0.0 9.3e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PGA_cap PF09587.8 174129.3_06528001_1 - 0.079 12.3 0.1 0.24 10.7 0.1 1.7 1 1 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap 7tm_1 PF00001.19 001304738.1_45726001_2 - 1.9e-58 197.7 28.2 2.7e-58 197.2 28.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001304738.1_45726001_2 - 1.6e-08 34.1 26.8 2.5e-08 33.5 26.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001304738.1_45726001_2 - 5e-05 22.6 28.0 8e-05 21.9 28.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx TCR_zetazeta PF11628.6 001205304.1_45724001_3 - 2.7e-17 62.0 0.7 4.8e-17 61.2 0.7 1.4 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 zeta chain ITAM PF02189.13 001205304.1_45724001_3 - 1.3e-12 47.2 3.2 1.3e-05 25.3 0.1 2.9 3 0 0 3 3 3 2 Immunoreceptor tyrosine-based activation motif Flavodoxin_2 PF02525.15 000904.4_26223001_2 - 3e-51 173.8 0.0 3.6e-51 173.6 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.13 000904.4_26223001_2 - 3.3e-12 46.3 0.0 6.4e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Spin-Ssty PF02513.15 001195370.1_49823001_2 - 1.2e-75 249.0 7.1 2.6e-27 94.2 0.1 3.2 3 0 0 3 3 3 3 Spin/Ssty Family Med25 PF11232.6 017432.4_26224001_3 - 6.3e-111 367.0 0.6 1.5e-54 184.0 0.0 2.1 2 0 0 2 2 2 2 Mediator complex subunit 25 PTOV activation and synapsin 2 7tm_1 PF00001.19 001304733.1_45724001_1 - 9.3e-55 185.6 26.0 1.4e-54 185.0 26.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUSP PF06337.10 001351162.1_26221001_1 - 9.9e-12 45.2 0.4 1.3e-11 44.8 0.4 1.2 1 0 0 1 1 1 1 DUSP domain DUF788 PF05620.9 001013427.1_45722001_1 - 1.2 9.0 5.9 1.4 8.7 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF788) DUF4604 PF15377.4 001013427.1_45722001_2 - 0.0026 18.1 11.1 0.0033 17.8 11.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) SR-25 PF10500.7 001013427.1_45722001_2 - 0.23 10.9 25.7 0.33 10.4 25.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.9 001013427.1_45722001_3 - 0.021 15.0 16.8 0.028 14.6 16.8 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 OATP PF03137.18 001013427.1_45722001_3 - 2.1 6.4 5.5 2.6 6.1 5.5 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family ABC_export PF16962.3 001013427.1_45722001_3 - 4.7 5.4 5.9 5.4 5.2 5.9 1.1 1 0 0 1 1 1 0 Putative ABC exporter ABC2_membrane PF01061.22 001347418.1_32928001_1 - 7.4e-34 116.9 14.0 7.4e-34 116.9 14.0 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.25 001347418.1_32928001_1 - 4.1e-28 98.5 0.0 6.7e-28 97.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 001347418.1_32928001_1 - 0.0083 15.8 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF258 PF03193.14 001347418.1_32928001_1 - 0.05 13.4 0.0 0.097 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NGF PF00243.16 001270869.1_45723001_3 - 3.1e-51 172.2 3.4 4.6e-51 171.7 3.4 1.2 1 0 0 1 1 1 1 Nerve growth factor family MHC_I PF00129.16 001318357.1_29623001_1 - 9.3e-92 305.4 0.5 1.3e-91 304.9 0.5 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001318357.1_29623001_1 - 1e-16 61.1 0.0 2.1e-16 60.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001318357.1_29623001_1 - 1.8e-12 46.8 9.4 3.3e-12 46.0 9.4 1.5 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001318357.1_29623001_1 - 5.1e-06 26.9 0.6 0.026 15.0 0.0 2.7 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001318357.1_29623001_1 - 0.00031 20.6 0.1 0.00072 19.5 0.1 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001318357.1_29623001_1 - 0.025 14.6 0.1 0.09 12.8 0.0 2.0 2 1 0 2 2 2 0 Immunoglobulin domain DUF1394 PF07159.10 001353289.1_26229001_1 - 1.7e-146 487.1 0.2 2.3e-146 486.7 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) DUF1394 PF07159.10 016623.4_26228001_3 - 7e-151 501.5 0.2 8.6e-151 501.2 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) Phe_ZIP PF08916.9 001359231.1_26225001_2 - 7.9e-19 68.0 5.1 1.6e-18 67.0 5.1 1.6 1 0 0 1 1 1 1 Phenylalanine zipper SH2 PF00017.22 001359231.1_26225001_2 - 3.1e-13 49.4 0.0 6.2e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 SH2 domain PH PF00169.27 001359231.1_26225001_2 - 1.3e-11 44.8 0.0 2.6e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 001359231.1_26225001_2 - 0.056 13.7 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain zf-C4 PF00105.16 121656.1_32927120_1 - 3.5e-31 107.3 15.1 9.2e-31 106.0 15.1 1.8 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 121656.1_32927120_3 - 1.3e-16 60.7 0.5 2.2e-16 59.9 0.5 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor UPF0193 PF05250.9 132765.1_06524120_2 - 7.6e-59 199.0 1.2 1.3e-58 198.2 1.2 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0193) UPF0193 PF05250.9 132765.1_06524120_3 - 1.6e-23 83.5 1.7 3.3e-23 82.5 1.7 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0193) ABC2_membrane PF01061.22 104382.1_32927120_1 - 5.4e-34 117.3 14.0 5.4e-34 117.3 14.0 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.25 104382.1_32927120_1 - 3e-28 98.9 0.0 5.1e-28 98.2 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 104382.1_32927120_1 - 0.0063 16.2 0.0 0.01 15.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF258 PF03193.14 104382.1_32927120_1 - 0.038 13.8 0.0 0.076 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Y_phosphatase PF00102.25 104070.1_32926120_3 - 3.2e-77 259.1 0.2 4.9e-77 258.5 0.2 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 104070.1_32926120_3 - 0.00014 21.8 0.0 0.00025 20.9 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 104070.1_32926120_3 - 0.068 12.9 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Phospholip_A2_1 PF00068.17 002926.3_32922120_2 - 3.8e-07 30.4 0.8 5.4e-07 29.9 0.8 1.2 1 0 0 1 1 1 1 Phospholipase A2 Phospholip_A2_1 PF00068.17 002926.3_32922120_3 - 4.6e-23 81.6 16.0 6.5e-23 81.1 16.0 1.2 1 0 0 1 1 1 1 Phospholipase A2 Phospholip_A2_2 PF05826.10 002926.3_32922120_3 - 0.95 9.6 17.5 34 4.6 17.5 2.1 1 1 0 1 1 1 0 Phospholipase A2 Ank_2 PF12796.5 146790.1_26229120_2 - 1.4e-34 118.4 1.5 8.1e-12 45.4 0.2 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 146790.1_26229120_2 - 3.3e-32 110.3 3.4 6.1e-11 42.5 0.1 5.7 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 146790.1_26229120_2 - 2.9e-26 88.5 1.8 2.3e-05 24.3 0.0 7.1 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.28 146790.1_26229120_2 - 5e-26 89.8 9.7 1.9e-06 27.9 0.1 7.2 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.4 146790.1_26229120_2 - 1.3e-23 82.6 6.9 1.9e-08 34.3 0.1 4.4 2 2 2 4 4 4 4 Ankyrin repeats (many copies) HECT PF00632.23 146790.1_26229120_3 - 1.1e-90 304.1 0.0 1.4e-90 303.8 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) PID PF00640.21 045562.1_26227120_1 - 9.3e-32 109.8 0.5 1.4e-31 109.2 0.5 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 045562.1_26227120_1 - 5.4e-11 42.6 0.1 9.4e-11 41.9 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.4 045562.1_26227120_1 - 1.7e-05 24.7 0.0 2.6e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) bZIP_2 PF07716.13 045562.1_26227120_1 - 0.0068 16.3 3.9 0.012 15.5 3.9 1.4 1 0 0 1 1 1 1 Basic region leucine zipper DivIC PF04977.13 045562.1_26227120_1 - 0.026 14.1 3.9 0.051 13.2 3.9 1.3 1 0 0 1 1 1 0 Septum formation initiator Ax_dynein_light PF10211.7 045562.1_26227120_1 - 0.03 14.1 0.4 0.055 13.3 0.4 1.3 1 0 0 1 1 1 0 Axonemal dynein light chain Pox_A_type_inc PF04508.10 045562.1_26227120_1 - 0.046 13.4 0.8 1.1 9.1 0.2 2.5 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat IncA PF04156.12 045562.1_26227120_1 - 0.084 12.5 0.3 0.14 11.8 0.3 1.2 1 0 0 1 1 1 0 IncA protein bZIP_1 PF00170.19 045562.1_26227120_1 - 0.11 12.5 1.6 0.19 11.7 1.6 1.3 1 0 0 1 1 1 0 bZIP transcription factor TSC22 PF01166.16 045562.1_26227120_1 - 0.11 12.7 1.3 0.25 11.6 1.3 1.6 1 0 0 1 1 1 0 TSC-22/dip/bun family Josephin PF02099.15 028457.1_26229120_1 - 2e-19 70.1 0.1 3.1e-19 69.5 0.1 1.3 1 0 0 1 1 1 1 Josephin Josephin PF02099.15 028457.1_26229120_2 - 4.2e-15 56.1 0.3 6.7e-15 55.4 0.3 1.2 1 0 0 1 1 1 1 Josephin SUIM_assoc PF16619.3 028457.1_26229120_3 - 3.1e-31 107.1 7.4 6.6e-31 106.1 7.4 1.6 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 UIM PF02809.18 028457.1_26229120_3 - 7.1e-11 41.1 19.8 0.00041 20.0 0.8 3.7 3 0 0 3 3 3 3 Ubiquitin interaction motif DUF2967 PF11179.6 028457.1_26229120_3 - 0.83 8.9 6.5 1.3 8.3 6.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) 7tm_1 PF00001.19 027877.1_45724120_1 - 6.4e-59 199.2 28.2 9.1e-59 198.7 28.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 027877.1_45724120_1 - 6.4e-09 35.4 26.9 8.2e-09 35.1 26.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 027877.1_45724120_1 - 2e-05 23.9 28.2 3.1e-05 23.3 28.2 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 027877.1_45724120_1 - 0.0023 17.6 20.3 0.0048 16.5 20.3 1.5 1 1 0 1 1 1 1 Olfactory receptor Metallophos_2 PF12850.5 152872.1_32926120_2 - 1.9e-18 67.1 0.0 2.7e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.26 152872.1_32926120_2 - 0.12 12.7 0.3 0.47 10.8 0.3 1.9 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase IncA PF04156.12 145925.3_32925001_3 - 0.00057 19.6 0.0 0.00096 18.9 0.0 1.3 1 0 0 1 1 1 1 IncA protein EphA2_TM PF14575.4 145925.3_32925001_3 - 0.011 16.3 0.0 0.024 15.3 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain 7tm_2 PF00002.22 173071.3_32929001_3 - 2e-62 210.5 14.8 3.1e-62 210.0 14.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) TSP_1 PF00090.17 173071.3_32929001_3 - 1.2e-36 124.5 73.7 6.6e-12 45.3 8.4 5.2 5 0 0 5 5 5 4 Thrombospondin type 1 domain GAIN PF16489.3 173071.3_32929001_3 - 6.6e-36 123.6 0.0 1e-35 122.9 0.0 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.19 173071.3_32929001_3 - 1.3e-12 48.0 5.6 4.6e-12 46.2 5.6 2.1 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_1 PF00001.19 173071.3_32929001_3 - 7.7e-05 21.9 0.0 0.00013 21.2 0.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Forkhead PF00250.16 013519.2_32926001_1 - 2.7e-39 133.2 0.1 4.3e-39 132.6 0.1 1.3 1 0 0 1 1 1 1 Forkhead domain PDZ PF00595.22 001008792.2_32929001_3 - 6.4e-46 154.5 2.5 1.2e-18 67.1 0.0 3.4 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001008792.2_32929001_3 - 1.4e-14 54.0 0.1 0.00038 20.6 0.0 3.6 3 0 0 3 3 3 3 PDZ domain CCM2_C PF16545.3 001008792.2_32929001_3 - 0.0014 19.0 0.8 0.49 10.8 0.1 2.3 2 0 0 2 2 2 2 Cerebral cavernous malformation protein, harmonin-homology Tricorn_PDZ PF14685.4 001008792.2_32929001_3 - 0.0092 15.8 0.3 32 4.5 0.0 3.6 3 0 0 3 3 3 1 Tricorn protease PDZ domain Glyco_transf_29 PF00777.16 001276425.1_32928001_3 - 6.3e-34 117.4 0.0 1e-33 116.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Guanylate_cyc PF00211.18 021896.6_32929001_2 - 1.5e-62 210.4 0.0 2.1e-62 209.8 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.12 021896.6_32929001_2 - 5.8e-45 153.2 0.6 1.9e-44 151.6 0.6 1.8 1 1 0 1 1 1 1 Heme NO binding associated HNOB PF07700.13 021896.6_32929001_2 - 3.7e-05 23.6 0.0 5.9e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Haem-NO-binding Peptidase_M10 PF00413.22 001081847.2_21024001_3 - 4.7e-62 208.4 0.0 8.6e-62 207.5 0.0 1.5 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 001081847.2_21024001_3 - 8.2e-44 147.2 23.7 2e-16 59.5 0.3 4.9 5 0 0 5 5 5 4 Hemopexin PG_binding_1 PF01471.16 001081847.2_21024001_3 - 1.8e-14 53.5 0.6 5.2e-14 52.1 0.1 2.1 3 0 0 3 3 3 1 Putative peptidoglycan binding domain Astacin PF01400.22 001081847.2_21024001_3 - 0.0066 16.0 0.0 4.4 6.7 0.0 2.6 3 0 0 3 3 3 2 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.4 001081847.2_21024001_3 - 0.018 15.4 0.0 0.031 14.7 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001081847.2_21024001_3 - 0.031 13.8 0.0 0.048 13.2 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 001081847.2_21024001_3 - 0.043 13.8 0.1 0.069 13.2 0.1 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF4953 PF16313.3 001081847.2_21024001_3 - 0.059 12.4 0.0 0.14 11.2 0.0 1.5 1 0 0 1 1 1 0 Met-zincin tRNA_m1G_MT PF01746.19 001257537.1_29623001_1 - 6.4e-40 136.8 0.6 9.9e-40 136.2 0.0 1.6 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase Myb_DNA-binding PF00249.29 152859.1_32928120_2 - 6.2e-29 99.8 11.8 3.4e-19 68.6 0.6 4.4 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 152859.1_32928120_2 - 2.4e-16 59.6 4.3 7.8e-09 35.5 0.1 4.2 3 1 1 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.4 152859.1_32928120_2 - 0.27 11.5 6.3 0.093 13.0 0.4 3.1 3 1 1 4 4 4 0 Myb/SANT-like DNA-binding domain RRM_1 PF00076.20 131120.1_32929120_1 - 1.9e-24 85.1 0.2 3.9e-14 52.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 131120.1_32929120_1 - 2.7e-06 27.3 0.1 0.033 14.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.9 131120.1_32929120_1 - 0.091 12.7 0.0 1.5 8.7 0.0 2.1 2 0 0 2 2 2 0 RNA binding motif Globin PF00042.20 001294308.1_32924001_1 - 5.2e-12 46.2 0.0 7.5e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Globin Cadherin_C PF01049.15 004949.4_26229001_1 - 9.8e-06 25.8 0.0 1.4e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin PF00028.15 004949.4_26229001_3 - 9.8e-72 237.3 4.4 7.4e-19 67.9 0.9 5.3 5 0 0 5 5 5 4 Cadherin domain Cadherin_pro PF08758.9 004949.4_26229001_3 - 3.1e-18 65.6 0.6 1e-16 60.7 0.1 3.2 3 0 0 3 3 3 1 Cadherin prodomain like Cadherin_2 PF08266.10 004949.4_26229001_3 - 0.005 16.5 0.0 8.5 6.1 0.0 3.8 4 0 0 4 4 4 1 Cadherin-like Cadherin_3 PF16184.3 004949.4_26229001_3 - 0.015 15.2 6.0 2.1 8.2 0.6 3.9 4 0 0 4 4 4 0 Cadherin-like He_PIG PF05345.10 004949.4_26229001_3 - 0.16 12.1 0.8 1.6 8.8 0.0 2.9 3 0 0 3 3 3 0 Putative Ig domain SAM_1 PF00536.28 001352189.1_26227001_1 - 3.9e-35 120.0 0.1 3.6e-16 59.2 0.1 2.3 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 001352189.1_26227001_1 - 2.3e-28 97.9 0.4 4.8e-15 55.3 0.1 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PID PF00640.21 001352189.1_26227001_1 - 3.3e-20 72.4 0.7 5.1e-20 71.8 0.7 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 001352189.1_26227001_1 - 0.00018 21.5 0.1 0.00033 20.7 0.1 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain Coq4 PF05019.11 001352189.1_26227001_1 - 0.0022 17.2 0.0 0.0053 16.0 0.0 1.5 1 1 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 PID_2 PF14719.4 001352189.1_26227001_1 - 0.0044 16.8 0.0 0.0083 15.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) NUDIX_4 PF14815.4 001316747.1_32924001_2 - 2.4e-23 82.1 0.9 3.6e-23 81.5 0.1 1.8 2 0 0 2 2 2 1 NUDIX domain HhH-GPD PF00730.23 001316747.1_32924001_2 - 9e-14 51.7 0.0 1.7e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.21 001316747.1_32924001_2 - 1e-08 34.5 0.0 3.1e-08 32.9 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.7 001316747.1_32924001_2 - 0.00025 21.1 4.5 0.0007 19.7 4.5 1.8 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III Hist_deacetyl PF00850.17 027382.4_32924001_2 - 4.3e-80 269.3 0.0 5.5e-80 269.0 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain SNAP-25 PF00835.17 022689.2_45726001_2 - 5.7e-23 80.8 1.4 1.2e-22 79.8 1.4 1.6 1 0 0 1 1 1 1 SNAP-25 family DUF5089 PF17002.3 022689.2_45726001_2 - 0.0011 18.8 8.0 0.004 16.9 8.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF5089) V-SNARE_C PF12352.6 022689.2_45726001_2 - 0.015 15.4 6.3 0.17 12.1 1.0 2.5 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Use1 PF09753.7 022689.2_45726001_2 - 0.052 13.1 1.1 0.083 12.4 1.1 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 DUF16 PF01519.14 022689.2_45726001_2 - 3.9 7.9 7.7 10 6.5 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF1664 PF07889.10 022689.2_45726001_2 - 7.2 6.5 7.7 2.1 8.2 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) HMG_box PF00505.17 010439.4_32926001_2 - 1.9e-42 143.4 13.1 2.6e-26 91.7 0.7 2.5 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.8 010439.4_32926001_2 - 1.8e-41 140.4 14.3 3.2e-26 91.6 8.3 2.5 2 0 0 2 2 2 2 HMG-box domain HMG_box_5 PF14887.4 010439.4_32926001_2 - 0.052 13.4 12.9 0.8 9.6 2.2 2.4 2 0 0 2 2 2 0 HMG (high mobility group) box 5 Nucleo_P87 PF07267.9 010439.4_32926001_2 - 1 8.0 9.0 1.2 7.7 9.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Nop14 PF04147.10 010439.4_32926001_2 - 2.6 6.0 23.8 3.5 5.6 23.8 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.10 010439.4_32926001_2 - 8.9 5.5 22.6 15 4.7 22.6 1.2 1 0 0 1 1 1 0 NOA36 protein MoCF_biosynth PF00994.22 022865.3_45727001_3 - 6.4e-69 230.0 0.0 3.4e-41 140.1 0.0 2.3 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.15 022865.3_45727001_3 - 8.6e-33 112.7 0.1 2e-32 111.5 0.1 1.6 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.13 022865.3_45727001_3 - 2.7e-23 81.8 0.0 6.6e-23 80.5 0.0 1.7 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) SAM_1 PF00536.28 001204068.1_26228001_2 - 8.5e-36 122.1 0.2 4.1e-16 59.0 0.1 3.1 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 001204068.1_26228001_2 - 2.5e-28 97.9 0.4 5.4e-15 55.1 0.1 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PID PF00640.21 001204068.1_26228001_2 - 5.8e-20 71.6 0.7 5.8e-20 71.6 0.7 2.0 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 001204068.1_26228001_2 - 0.00022 21.3 0.1 0.00037 20.5 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain EABR PF12180.6 001127182.1_26226001_3 - 2e-18 65.6 2.3 4.8e-18 64.3 2.3 1.7 1 0 0 1 1 1 1 TSG101 and ALIX binding domain of CEP55 zf-C2H2_3 PF13878.4 001127182.1_26226001_3 - 0.0087 15.7 0.2 0.018 14.7 0.2 1.5 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Cep57_CLD_2 PF14197.4 001127182.1_26226001_3 - 0.013 15.4 7.1 0.013 15.4 7.1 4.8 3 2 1 4 4 4 0 Centrosome localisation domain of PPC89 CENP-F_leu_zip PF10473.7 001127182.1_26226001_3 - 3.8 7.4 68.7 0.46 10.4 8.5 4.4 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PALB2_WD40 PF16756.3 001289842.1_32927001_3 - 2.8e-114 381.6 1.8 4.5e-114 380.9 1.8 1.2 1 0 0 1 1 1 1 Partner and localizer of BRCA2 WD40 domain DUF573 PF04504.12 001289842.1_32927001_3 - 0.93 10.1 4.3 0.49 11.0 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF573 IL22 PF14565.4 001191988.1_45722001_1 - 5e-71 237.3 0.2 5.8e-71 237.1 0.2 1.0 1 0 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor IL10 PF00726.15 001191988.1_45722001_1 - 4.5e-07 29.4 0.2 5.7e-07 29.1 0.2 1.1 1 0 0 1 1 1 1 Interleukin 10 BshC PF10079.7 001191988.1_45722001_1 - 0.0039 15.9 0.0 0.0047 15.6 0.0 1.0 1 0 0 1 1 1 1 Bacillithiol biosynthesis BshC Pentaxin PF00354.15 001244783.1_49824001_2 - 8.4e-30 103.8 0.0 1.3e-29 103.2 0.0 1.2 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.4 001244783.1_49824001_2 - 1.9e-18 66.9 0.0 2.9e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily eIF-6 PF01912.16 001037352.1_45723001_1 - 9e-80 266.6 0.7 2.2e-79 265.3 0.2 1.7 2 0 0 2 2 2 1 eIF-6 family ADH_zinc_N PF00107.24 146213.1_26225120_2 - 3e-18 65.8 0.0 4.9e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 146213.1_26225120_2 - 5.2e-08 32.6 0.0 1.2e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.4 146213.1_26225120_2 - 2.2e-05 25.4 0.0 3.8e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PALP PF00291.23 146213.1_26225120_2 - 0.01 15.2 0.0 0.017 14.4 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme NUDIX PF00293.26 001359380.1_39729001_3 - 2.4e-05 24.3 0.1 5.3e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 NUDIX domain NUDIX PF00293.26 001359386.1_08022001_2 - 1.3e-06 28.4 0.1 1.9e-06 27.8 0.1 1.2 1 0 0 1 1 1 1 NUDIX domain Peptidase_C78 PF07910.11 153113.1_32925120_2 - 9.1e-74 247.4 0.0 1.2e-73 247.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C54 PF03416.17 153113.1_32925120_2 - 0.0064 15.8 0.0 0.0097 15.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C54 zf-Di19 PF05605.10 153113.1_32925120_3 - 6e-06 26.3 20.3 0.0039 17.3 0.4 4.8 4 1 0 4 4 4 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.4 153113.1_32925120_3 - 7.9e-06 26.1 13.8 0.6 11.0 0.0 5.2 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.5 153113.1_32925120_3 - 0.046 14.0 1.5 0.42 10.9 0.0 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.24 153113.1_32925120_3 - 1.1 9.8 0.0 1.1 9.8 0.0 5.2 5 1 0 5 5 5 0 Zinc finger, C2H2 type zf-DHHC PF01529.18 153112.1_32923120_1 - 0.0031 17.5 3.8 0.0031 17.5 3.8 2.9 2 1 0 2 2 2 1 DHHC palmitoyltransferase zf-DHHC PF01529.18 153112.1_32923120_3 - 1e-25 90.2 10.4 1.5e-25 89.7 10.4 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase Aha1_N PF09229.9 001102134.1_06523001_1 - 7.6e-34 116.7 0.4 1.2e-33 116.1 0.4 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.9 001102134.1_06523001_1 - 0.0042 17.2 0.0 0.0089 16.1 0.0 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein AHSA1 PF08327.9 001102134.1_06523001_3 - 1.2e-09 38.4 0.0 1.9e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein ENOD40 PF08247.9 001102134.1_06523001_3 - 0.67 9.9 2.6 1.3 9.1 2.6 1.5 1 0 0 1 1 1 0 ENOD40 protein Rtf2 PF04641.10 001193871.1_29624001_1 - 1.6e-94 316.0 8.1 2.5e-94 315.4 8.1 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger zf-NOSIP PF15906.3 001193871.1_29624001_1 - 0.0089 16.0 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein CNH PF00780.20 001359541.1_32929001_3 - 6.6e-74 248.8 0.1 1.6e-73 247.6 0.1 1.7 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.23 001359541.1_32929001_3 - 3e-55 187.3 0.0 6.2e-55 186.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain KELK PF15796.3 001359541.1_32929001_3 - 8.6e-29 99.7 20.4 8.6e-29 99.7 20.4 7.3 4 2 3 7 7 7 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase Pkinase_Tyr PF07714.15 001359541.1_32929001_3 - 8.7e-29 100.5 0.0 1.7e-28 99.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DMPK_coil PF08826.8 001359541.1_32929001_3 - 5.2e-26 90.4 12.4 5.2e-26 90.4 12.4 8.1 5 2 2 7 7 7 1 DMPK coiled coil domain like C1_1 PF00130.20 001359541.1_32929001_3 - 1.3e-09 37.7 10.4 4.1e-09 36.1 10.4 1.9 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.4 001359541.1_32929001_3 - 4.3e-06 26.1 0.0 4.3e-06 26.1 0.0 2.1 2 1 0 2 2 2 1 Kinase-like PBD PF00786.26 001359541.1_32929001_3 - 0.0001 22.5 0.5 0.16 12.3 0.1 2.9 2 0 0 2 2 2 2 P21-Rho-binding domain Pkinase_C PF00433.22 001359541.1_32929001_3 - 0.00016 22.2 1.6 0.00041 20.8 1.6 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Peptidase_C1 PF00112.21 001359387.1_32923001_2 - 3.4e-73 246.2 0.0 5.5e-73 245.6 0.0 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 001359387.1_32923001_2 - 1.1e-08 35.2 1.4 2.1e-08 34.3 1.4 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 001359387.1_32923001_2 - 0.02 13.6 0.2 1.3 7.6 0.1 2.1 2 0 0 2 2 2 0 Peptidase C1-like family PWWP PF00855.15 001246432.1_39725001_3 - 1.2e-10 41.6 0.1 2.7e-10 40.4 0.1 1.7 1 0 0 1 1 1 1 PWWP domain Fer4 PF00037.25 001071780.1_39722001_1 - 3.7e-14 51.7 17.5 1.4e-08 34.0 4.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.5 001071780.1_39722001_1 - 8.4e-13 48.6 10.5 1.5e-12 47.8 10.5 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.4 001071780.1_39722001_1 - 5.9e-11 43.0 6.8 3.2e-05 24.7 0.2 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.4 001071780.1_39722001_1 - 2.2e-09 37.2 31.8 7.6e-06 25.8 12.6 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_10 PF13237.4 001071780.1_39722001_1 - 1.2e-08 34.8 21.0 3.8e-06 26.8 12.5 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.4 001071780.1_39722001_1 - 1.3e-08 34.7 10.3 2.2e-08 34.0 10.3 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.5 001071780.1_39722001_1 - 2.5e-07 30.4 17.8 0.00033 20.5 5.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.4 001071780.1_39722001_1 - 8.8e-07 29.2 19.7 0.00035 20.8 11.9 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.5 001071780.1_39722001_1 - 1.1e-06 28.2 12.1 0.0024 17.8 1.9 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.5 001071780.1_39722001_1 - 6.1e-06 26.2 11.4 0.00029 21.0 2.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.4 001071780.1_39722001_1 - 0.00015 22.1 11.6 0.022 15.2 12.7 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.8 001071780.1_39722001_1 - 0.0044 17.1 5.8 0.43 10.7 0.5 2.3 1 1 1 2 2 2 2 c-SKI Smad4 binding domain Fer4_13 PF13370.4 001071780.1_39722001_1 - 0.011 16.2 14.8 0.52 10.8 2.7 2.5 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.4 001071780.1_39722001_1 - 0.031 14.3 8.5 0.92 9.6 1.4 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.5 001071780.1_39722001_1 - 0.15 13.0 16.4 0.29 12.0 4.1 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.11 001071780.1_39722001_1 - 0.21 11.6 5.8 1.1 9.3 0.6 2.4 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.2 001071780.1_39722001_1 - 0.7 10.6 11.9 2.3 9.0 1.8 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain 7tm_1 PF00001.19 001102240.2_06525001_3 - 2e-40 138.6 21.9 4.3e-40 137.5 21.9 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001102240.2_06525001_3 - 1.8e-05 23.9 17.3 4e-05 22.7 17.3 1.5 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Cullin PF00888.20 001280189.1_39726001_2 - 3.5e-175 584.0 20.2 4.7e-175 583.6 20.2 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.7 001280189.1_39726001_2 - 1.3e-26 92.2 4.7 1.3e-26 92.2 4.7 2.9 3 0 0 3 3 3 1 Cullin protein neddylation domain Rio2_N PF09202.9 001280189.1_39726001_2 - 0.004 17.2 1.3 0.012 15.6 0.2 2.3 2 0 0 2 2 2 1 Rio2, N-terminal Defensin_propep PF00879.16 001033907.1_39721001_1 - 7.5e-23 80.5 14.8 6.1e-21 74.4 14.8 2.1 1 1 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001033907.1_39721001_1 - 1.7e-07 31.5 15.5 2.3e-07 31.1 15.5 1.2 1 0 0 1 1 1 1 Mammalian defensin Defensin_beta_2 PF13841.4 001033907.1_39721001_1 - 0.098 13.0 9.6 0.19 12.1 9.6 1.5 1 1 0 1 1 1 0 Beta defensin ATP1G1_PLM_MAT8 PF02038.14 001243914.1_39722001_3 - 2.2e-26 90.8 0.1 2.2e-26 90.8 0.1 1.9 2 0 0 2 2 2 1 ATP1G1/PLM/MAT8 family Glycophorin_A PF01102.16 001243914.1_39722001_3 - 0.038 14.1 0.0 0.06 13.4 0.0 1.3 1 0 0 1 1 1 0 Glycophorin A TOH_N PF12549.6 001243914.1_39722001_3 - 0.15 11.8 4.1 0.17 11.7 1.5 2.3 1 1 1 2 2 2 0 Tyrosine hydroxylase N terminal Peptidase_M14 PF00246.22 001302409.1_39725001_2 - 1.1e-11 44.9 0.0 5e-11 42.8 0.0 2.2 1 1 0 1 1 1 1 Zinc carboxypeptidase FBP_C PF16571.3 001302409.1_39725001_3 - 0.0048 16.3 0.0 0.0078 15.6 0.0 1.3 1 0 0 1 1 1 1 FBP C-terminal treble-clef zinc-finger ANF_receptor PF01094.26 001034159.1_39726001_1 - 1.3e-61 208.6 0.0 2e-61 207.9 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 001034159.1_39726001_1 - 2.5e-48 163.5 0.1 4.1e-48 162.9 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 001034159.1_39726001_1 - 2e-44 150.3 0.0 7.4e-44 148.5 0.0 1.9 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001034159.1_39726001_1 - 6e-20 71.5 0.0 1e-19 70.7 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Reprolysin PF01421.17 001279791.1_39727001_3 - 7.7e-44 149.9 0.2 7.7e-44 149.9 0.2 2.1 3 0 0 3 3 3 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 001279791.1_39727001_3 - 3.2e-33 114.4 9.2 3.2e-33 114.4 9.2 3.9 2 1 0 3 3 3 1 ADAM cysteine-rich Disintegrin PF00200.21 001279791.1_39727001_3 - 5.7e-20 71.8 25.6 5.7e-20 71.8 25.6 4.9 5 1 0 5 5 5 1 Disintegrin Pep_M12B_propep PF01562.17 001279791.1_39727001_3 - 8.4e-18 64.8 0.0 1.8e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 001279791.1_39727001_3 - 4.6e-07 30.0 0.0 1.2e-06 28.7 0.0 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 001279791.1_39727001_3 - 6.9e-07 29.7 0.0 1.7e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 001279791.1_39727001_3 - 0.00021 21.1 0.2 0.00042 20.1 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001279791.1_39727001_3 - 0.00047 19.7 0.0 0.0011 18.5 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like BBS2_C PF14782.4 053618.1_45726001_3 - 4.7e-188 625.2 0.0 3.5e-187 622.3 0.0 1.9 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, C-terminal BBS2_N PF14781.4 053618.1_45726001_3 - 8.4e-59 197.2 0.0 1.5e-58 196.4 0.0 1.5 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, N-terminal BBS2_Mid PF14783.4 053618.1_45726001_3 - 3.2e-48 162.3 0.0 1.9e-46 156.5 0.0 2.7 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region FG-GAP PF01839.21 053618.1_45726001_3 - 1.5e-05 24.8 0.2 0.011 15.7 0.1 2.7 2 0 0 2 2 2 2 FG-GAP repeat VCBS PF13517.4 053618.1_45726001_3 - 0.00019 21.8 2.8 0.073 13.5 0.3 3.3 3 0 0 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Itfg2 PF15907.3 053618.1_45726001_3 - 0.0011 18.0 0.5 0.3 10.0 0.1 2.6 2 1 0 2 2 2 2 Integrin-alpha FG-GAP repeat-containing protein 2 ANF_receptor PF01094.26 016996.2_45729001_1 - 1.1e-108 363.4 0.0 1.4e-108 363.0 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 016996.2_45729001_1 - 4.1e-64 216.4 30.1 6.4e-64 215.8 30.1 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 016996.2_45729001_1 - 1.2e-16 60.3 12.2 1.2e-16 60.3 12.2 2.2 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 016996.2_45729001_1 - 1.1e-11 44.9 0.0 1.2e-10 41.5 0.0 2.2 2 1 0 2 2 2 1 Periplasmic binding protein Ephrin_rec_like PF07699.11 016996.2_45729001_1 - 0.017 14.7 7.7 0.052 13.2 7.7 1.8 1 0 0 1 1 1 0 Putative ephrin-receptor like Pex14_N PF04695.11 016996.2_45729001_1 - 2 9.0 9.6 0.8 10.3 6.8 1.7 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.11 016996.2_45729001_1 - 4.1 7.2 14.4 6.4 6.5 14.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FKBP_C PF00254.26 001082145.1_37921001_1 - 1.8e-32 111.4 0.0 2.1e-32 111.2 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase RYDR_ITPR PF01365.19 001082757.1_37929001_2 - 3.5e-141 467.4 9.0 4.3e-77 258.0 0.0 3.9 4 0 0 4 4 4 2 RIH domain RyR PF02026.14 001082757.1_37929001_2 - 6.3e-125 407.5 10.0 4.9e-33 113.0 0.0 5.4 5 0 0 5 5 5 4 RyR domain RR_TM4-6 PF06459.10 001082757.1_37929001_2 - 6.6e-94 314.7 1.4 2.4e-93 312.9 1.4 2.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 SPRY PF00622.26 001082757.1_37929001_2 - 1.1e-67 225.4 2.1 3e-24 85.3 0.1 3.6 3 0 0 3 3 3 3 SPRY domain Ins145_P3_rec PF08709.9 001082757.1_37929001_2 - 4.3e-63 212.2 0.1 1.2e-61 207.5 0.1 2.6 2 0 0 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.17 001082757.1_37929001_2 - 6.5e-56 189.0 0.2 1.6e-53 181.2 0.0 2.8 2 0 0 2 2 2 1 MIR domain RIH_assoc PF08454.9 001082757.1_37929001_2 - 1.1e-33 115.0 1.8 1.3e-32 111.5 0.3 3.6 3 1 1 4 4 4 1 RyR and IP3R Homology associated Ion_trans PF00520.29 001082757.1_37929001_2 - 2.2e-13 49.9 13.5 2.7e-13 49.6 5.3 3.8 3 0 0 3 3 3 1 Ion transport protein EF-hand_8 PF13833.4 001082757.1_37929001_2 - 1.5e-06 27.8 0.1 8.7e-06 25.3 0.1 2.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.4 001082757.1_37929001_2 - 8.7e-06 26.0 1.1 4.1e-05 23.8 1.1 2.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001082757.1_37929001_2 - 0.00038 19.7 0.5 0.0069 15.7 0.0 2.8 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 001082757.1_37929001_2 - 0.024 14.4 1.3 0.092 12.6 0.1 2.7 2 0 0 2 2 2 0 EF-hand domain GWT1 PF06423.10 001082757.1_37929001_2 - 0.58 10.2 4.9 5.1 7.1 0.0 3.7 3 0 0 3 3 3 0 GWT1 YjfB_motility PF14070.4 001082757.1_37929001_2 - 0.74 9.9 7.6 2.6 8.1 7.6 2.0 1 0 0 1 1 1 0 Putative motility protein Mucin PF01456.15 001009352.1_22422001_2 - 0.0045 16.8 11.3 0.0065 16.3 11.3 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein TNF PF00229.16 001009352.1_22422001_3 - 1.4e-33 115.4 1.4 2e-33 114.9 1.4 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Death PF00531.20 001009314.1_22423001_2 - 2.9e-19 68.9 0.2 5.1e-19 68.1 0.2 1.4 1 0 0 1 1 1 1 Death domain TNFR_c6 PF00020.16 001009314.1_22423001_2 - 4.2e-11 43.0 45.6 3.9e-08 33.4 10.1 3.7 2 1 0 3 3 3 3 TNFR/NGFR cysteine-rich region Stn1_C PF12659.5 001009314.1_22423001_2 - 0.082 12.7 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Telomere capping C-terminal wHTH DAGK_cat PF00781.22 001270807.1_45724001_2 - 7.9e-26 90.0 0.0 1.3e-25 89.3 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain OapA_N PF08525.9 001270807.1_45724001_3 - 3 7.7 6.1 38 4.2 3.6 2.4 2 0 0 2 2 2 0 Opacity-associated protein A N-terminal motif GM_CSF PF01109.15 000758.3_26222001_3 - 2.6e-69 230.9 0.1 3.3e-69 230.6 0.1 1.1 1 0 0 1 1 1 1 Granulocyte-macrophage colony-stimulating factor Ig_3 PF13927.4 006500.2_26227001_3 - 3.6e-37 126.7 4.6 3e-09 37.2 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 006500.2_26227001_3 - 2.7e-28 97.8 0.3 2.1e-05 24.4 0.0 5.7 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 006500.2_26227001_3 - 5.9e-28 96.9 0.0 4.6e-06 26.8 0.0 5.5 5 1 0 5 5 5 4 Immunoglobulin domain C2-set_2 PF08205.10 006500.2_26227001_3 - 5.1e-26 90.4 13.8 5.6e-22 77.5 0.0 5.2 6 0 0 6 6 6 3 CD80-like C2-set immunoglobulin domain I-set PF07679.14 006500.2_26227001_3 - 3.5e-23 81.3 2.9 0.00034 20.5 0.2 6.7 5 3 0 5 5 5 5 Immunoglobulin I-set domain V-set PF07686.15 006500.2_26227001_3 - 1.1e-16 60.8 4.0 3.4e-07 30.3 0.0 5.7 5 2 1 6 6 6 3 Immunoglobulin V-set domain DUF4366 PF14283.4 006500.2_26227001_3 - 0.086 12.2 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) DUF912 PF06024.10 006500.2_26227001_3 - 0.37 11.0 0.0 0.37 11.0 0.0 1.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Lactamase_B_3 PF13483.4 001113015.1_49824001_1 - 2.2e-09 37.3 0.0 4.1e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Rieske PF00355.24 001113015.1_49824001_1 - 2.7e-06 27.1 0.0 5.4e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Lactamase_B_2 PF12706.5 001113015.1_49824001_1 - 6.3e-05 22.5 0.0 0.00011 21.7 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain GCSF PF16647.3 172220.2_26223001_1 - 3.6e-61 205.2 3.5 8.1e-59 197.6 1.4 2.2 1 1 1 2 2 2 2 Granulocyte colony-stimulating factor NAGLU PF05089.10 172220.2_26223001_1 - 0.2 10.4 0.0 0.28 10.0 0.0 1.1 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain VWA PF00092.26 001303040.1_26229001_3 - 8e-39 133.6 0.0 1.1e-38 133.1 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Integrin_alpha2 PF08441.10 001303040.1_26229001_3 - 9e-38 130.2 0.0 1.3e-37 129.6 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 001303040.1_26229001_3 - 1.3e-16 60.3 9.5 2.6e-06 27.3 0.8 3.7 3 0 0 3 3 3 3 FG-GAP repeat VWA_2 PF13519.4 001303040.1_26229001_3 - 5.6e-10 39.7 0.0 1.1e-09 38.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VCBS PF13517.4 001303040.1_26229001_3 - 5.4e-07 30.0 0.9 0.00012 22.5 0.3 2.9 3 0 0 3 3 3 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella NHR2 PF08788.9 175636.2_26229001_2 - 3.8e-39 132.2 8.8 7.8e-39 131.2 8.8 1.6 1 0 0 1 1 1 1 NHR2 domain like TAFH PF07531.12 175636.2_26229001_2 - 7.3e-34 115.6 1.6 1.2e-33 114.9 1.6 1.4 1 0 0 1 1 1 1 NHR1 homology to TAF zf-MYND PF01753.16 175636.2_26229001_2 - 3.6e-07 30.0 18.2 1.4e-06 28.2 18.2 2.1 1 0 0 1 1 1 1 MYND finger DUF3731 PF12531.6 175636.2_26229001_2 - 0.077 12.7 0.8 0.13 11.9 0.8 1.2 1 0 0 1 1 1 0 DNA-K related protein Efg1 PF10153.7 175636.2_26229001_2 - 0.17 12.1 1.9 0.37 11.0 1.9 1.5 1 0 0 1 1 1 0 rRNA-processing protein Efg1 vATP-synt_E PF01991.16 175636.2_26229001_2 - 5.8 6.1 11.1 9 5.5 11.1 1.2 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit NHR2 PF08788.9 001198629.1_26229001_3 - 3.8e-39 132.2 8.8 7.9e-39 131.1 8.8 1.6 1 0 0 1 1 1 1 NHR2 domain like TAFH PF07531.12 001198629.1_26229001_3 - 7.4e-34 115.5 1.6 1.2e-33 114.8 1.6 1.4 1 0 0 1 1 1 1 NHR1 homology to TAF zf-MYND PF01753.16 001198629.1_26229001_3 - 3.5e-07 30.1 18.2 1.4e-06 28.2 18.2 2.2 1 0 0 1 1 1 1 MYND finger DUF3731 PF12531.6 001198629.1_26229001_3 - 0.078 12.6 0.8 0.13 11.9 0.8 1.2 1 0 0 1 1 1 0 DNA-K related protein Efg1 PF10153.7 001198629.1_26229001_3 - 0.17 12.1 1.9 0.38 11.0 1.9 1.5 1 0 0 1 1 1 0 rRNA-processing protein Efg1 vATP-synt_E PF01991.16 001198629.1_26229001_3 - 5.9 6.1 11.1 9.1 5.5 11.1 1.2 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit Ion_trans PF00520.29 001195199.1_45729001_1 - 4.1e-249 821.8 82.8 2.1e-67 226.8 1.8 4.1 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.3 001195199.1_45729001_1 - 7.8e-38 128.0 0.0 3e-37 126.1 0.0 2.0 2 0 0 2 2 2 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 001195199.1_45729001_1 - 5e-32 109.9 0.0 1.3e-31 108.6 0.0 1.8 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 001195199.1_45729001_1 - 2.1e-09 36.4 26.3 4e-07 28.9 7.8 9.3 6 4 2 10 10 10 5 Polycystin cation channel Ank_2 PF12796.5 001354243.1_26229001_2 - 2.7e-148 482.8 45.9 1.2e-17 64.1 0.2 12.3 1 1 11 12 12 12 12 Ankyrin repeats (3 copies) Ank PF00023.28 001354243.1_26229001_2 - 1.3e-134 433.2 69.0 5.3e-07 29.7 0.5 23.5 23 0 0 23 23 23 21 Ankyrin repeat Ank_4 PF13637.4 001354243.1_26229001_2 - 1.2e-124 405.0 33.0 1.8e-12 47.4 0.1 15.3 7 4 9 17 17 17 17 Ankyrin repeats (many copies) Ank_5 PF13857.4 001354243.1_26229001_2 - 4.9e-119 386.1 50.3 2.7e-11 43.4 0.6 19.0 2 2 19 21 21 21 20 Ankyrin repeats (many copies) Ank_3 PF13606.4 001354243.1_26229001_2 - 3.6e-113 355.5 34.6 3.7e-05 23.7 0.0 24.0 23 0 0 23 23 23 21 Ankyrin repeat ZU5 PF00791.18 001354243.1_26229001_2 - 2.5e-39 133.4 0.6 7e-16 58.2 0.0 3.7 2 1 1 3 3 3 3 ZU5 domain Death PF00531.20 001354243.1_26229001_2 - 5e-22 77.7 0.9 1.1e-21 76.6 0.9 1.6 1 0 0 1 1 1 1 Death domain PK_C PF02887.14 001354243.1_26229001_2 - 5.6e-06 26.4 3.6 7 6.8 0.0 5.9 5 1 1 6 6 6 2 Pyruvate kinase, alpha/beta domain HTH_23 PF13384.4 001354243.1_26229001_2 - 0.12 12.1 0.1 1.4 8.7 0.1 3.0 2 0 0 2 2 2 0 Homeodomain-like domain IL8 PF00048.18 021274.2_32923001_1 - 1.3e-12 47.5 0.4 1.3e-12 47.5 0.4 2.1 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like Pyr_redox_2 PF07992.12 000637.4_26227001_3 - 3.9e-61 206.7 0.1 5.3e-61 206.3 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 000637.4_26227001_3 - 1.3e-35 121.8 1.0 1.3e-35 121.8 1.0 1.7 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 000637.4_26227001_3 - 1.4e-20 73.4 5.7 1.9e-19 69.9 0.4 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 000637.4_26227001_3 - 3.6e-16 59.1 0.1 8.1e-16 58.0 0.1 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.5 000637.4_26227001_3 - 4.9e-06 26.0 0.1 1.1e-05 24.9 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 000637.4_26227001_3 - 9.3e-06 24.8 4.4 0.0041 16.1 2.5 2.5 3 0 0 3 3 3 2 FAD binding domain AlaDh_PNT_C PF01262.19 000637.4_26227001_3 - 0.00023 20.4 2.2 0.11 11.7 0.5 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.20 000637.4_26227001_3 - 0.0051 15.8 3.7 0.02 13.8 1.3 2.5 3 0 0 3 3 3 1 Glucose inhibited division protein A NAD_binding_8 PF13450.4 000637.4_26227001_3 - 0.0089 16.1 0.5 0.026 14.6 0.5 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.12 000637.4_26227001_3 - 0.019 13.5 0.6 0.17 10.4 0.5 2.2 2 0 0 2 2 2 0 HI0933-like protein DAO PF01266.22 000637.4_26227001_3 - 0.034 13.7 3.3 0.16 11.4 3.2 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.17 000637.4_26227001_3 - 0.59 9.2 2.7 1.9 7.5 0.4 2.0 2 0 0 2 2 2 0 FAD binding domain PMP22_Claudin PF00822.18 001281456.1_26224001_1 - 6.3e-51 172.4 13.9 9.4e-51 171.8 13.9 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001281456.1_26224001_1 - 6.7e-06 25.9 11.4 6.7e-06 25.9 11.4 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction L_HMGIC_fpl PF10242.7 001281456.1_26224001_1 - 0.00093 19.3 8.6 0.002 18.2 8.6 1.5 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein DUF4064 PF13273.4 001281456.1_26224001_1 - 0.094 12.9 10.1 0.27 11.5 7.7 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) DUF4834 PF16118.3 001281456.1_26224001_1 - 7.3 7.5 7.1 38 5.2 1.3 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) E1-E2_ATPase PF00122.18 001089318.1_37927001_1 - 1.4e-64 217.3 1.2 1.4e-64 217.3 1.2 2.3 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 001089318.1_37927001_1 - 8.3e-44 149.3 0.9 1.8e-43 148.3 0.9 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.24 001089318.1_37927001_1 - 1.2e-20 72.8 0.2 7.8e-20 70.2 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.4 001089318.1_37927001_1 - 3.3e-20 71.8 0.6 6.8e-20 70.8 0.6 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 001089318.1_37927001_1 - 2.7e-18 66.9 0.1 3.8e-17 63.1 0.1 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 001089318.1_37927001_1 - 5.6e-06 26.1 0.6 1.1e-05 25.2 0.6 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 001089318.1_37927001_1 - 0.0055 17.0 0.0 0.021 15.1 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase SAND PF01342.19 001089318.1_37927001_1 - 0.18 11.4 0.3 0.51 10.0 0.3 1.7 1 0 0 1 1 1 0 SAND domain 7tm_1 PF00001.19 012784.4_45729001_3 - 7e-43 146.6 15.8 7e-43 146.6 15.8 2.0 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) PLA2_B PF01735.16 001305632.1_32926001_2 - 1.6e-144 481.8 0.0 2e-144 481.5 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain C2 PF00168.28 001305632.1_32926001_2 - 1.8e-16 60.2 0.1 4e-16 59.1 0.1 1.6 1 0 0 1 1 1 1 C2 domain Tropomyosin PF00261.18 001034070.1_45724001_2 - 2.5e-92 308.4 83.9 1.3e-88 296.3 60.5 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.5 001034070.1_45724001_2 - 2.7e-40 137.7 69.2 9.7e-37 126.1 39.8 3.1 2 1 0 2 2 2 2 Tropomyosin like CLZ PF16526.3 001034070.1_45724001_2 - 1.1e-07 32.0 49.2 0.0001 22.4 10.5 4.6 2 2 1 4 4 4 4 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TMF_DNA_bd PF12329.6 001034070.1_45724001_2 - 0.0011 18.8 13.8 0.0011 18.8 13.8 5.7 2 1 3 5 5 5 3 TATA element modulatory factor 1 DNA binding Laminin_II PF06009.10 001034070.1_45724001_2 - 0.0012 18.7 37.4 0.073 12.9 4.9 4.1 1 1 3 4 4 4 4 Laminin Domain II IncA PF04156.12 001034070.1_45724001_2 - 0.004 16.8 23.8 0.004 16.8 23.8 2.6 1 1 2 3 3 3 1 IncA protein ERM PF00769.17 001034070.1_45724001_2 - 0.86 9.2 70.3 4.6 6.8 25.1 3.1 1 1 2 3 3 3 0 Ezrin/radixin/moesin family DUF1664 PF07889.10 001034070.1_45724001_2 - 1 9.3 29.7 0.21 11.5 4.9 3.7 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) AAA_13 PF13166.4 001034070.1_45724001_2 - 1.2 7.6 44.8 1.9 6.9 27.4 2.1 1 1 1 2 2 2 0 AAA domain SNARE PF05739.17 001034070.1_45724001_2 - 1.9 8.4 8.8 3.8 7.4 0.1 4.4 4 1 1 5 5 5 0 SNARE domain Fib_alpha PF08702.8 001034070.1_45724001_2 - 7.2 6.7 31.0 0.35 10.9 8.9 3.1 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Laminin_I PF06008.12 001034070.1_45724001_2 - 9.6 5.7 55.8 0.12 11.9 15.7 3.1 1 1 2 3 3 3 0 Laminin Domain I Kisspeptin PF15152.4 001285710.2_09022001_3 - 7.9e-37 125.8 0.8 7.9e-37 125.8 0.8 1.9 2 0 0 2 2 2 1 Kisspeptin Kisspeptin PF15152.4 001144132.1_32321001_1 - 1.2e-36 125.2 0.3 1.2e-36 125.2 0.3 1.4 2 0 0 2 2 2 1 Kisspeptin RFamide_26RFa PF11109.6 001144132.1_32321001_1 - 0.046 14.2 0.0 0.18 12.2 0.0 1.8 2 0 0 2 2 2 0 Orexigenic neuropeptide Qrfp/P518 Kisspeptin PF15152.4 001281568.1_31322001_1 - 7e-35 119.5 0.6 1.2e-34 118.8 0.6 1.4 1 0 0 1 1 1 1 Kisspeptin p450 PF00067.20 001111303.2_21024001_1 - 2e-143 478.3 0.2 2.4e-143 478.1 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 SID-1_RNA_chan PF13965.4 001359653.1_32929001_2 - 4.1e-284 943.6 10.1 5.1e-284 943.3 10.1 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Defensin_beta PF00711.17 001359653.1_32929001_2 - 1.7 8.6 6.6 0.63 10.0 2.4 2.6 2 0 0 2 2 2 0 Beta defensin Filament PF00038.19 001110818.1_39725001_2 - 1.1e-104 350.2 40.9 1.3e-104 350.0 40.9 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001110818.1_39725001_2 - 5.9e-42 143.4 62.0 5.9e-42 143.4 62.0 3.4 2 1 1 3 3 1 1 Keratin type II head Keratin_2_tail PF16210.3 001110818.1_39725001_2 - 4.7e-31 107.7 127.0 4.7e-31 107.7 127.0 3.7 2 2 1 3 3 1 1 Keratin type II cytoskeletal 1 tail TPR_MLP1_2 PF07926.10 001110818.1_39725001_2 - 5e-08 32.9 36.4 1e-05 25.4 3.7 3.7 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein AAA_13 PF13166.4 001110818.1_39725001_2 - 5.5e-06 25.2 21.7 5.5e-06 25.2 21.7 1.9 1 1 0 1 1 1 1 AAA domain Spc7 PF08317.9 001110818.1_39725001_2 - 2.1e-05 23.5 40.6 0.00011 21.1 15.1 3.0 1 1 2 3 3 3 2 Spc7 kinetochore protein Alanine_zipper PF11839.6 001110818.1_39725001_2 - 0.0001 22.4 8.2 0.00017 21.7 1.6 3.0 2 1 1 3 3 3 1 Alanine-zipper, major outer membrane lipoprotein DUF4407 PF14362.4 001110818.1_39725001_2 - 0.00011 21.6 25.2 0.00014 21.2 5.3 2.5 1 1 0 2 2 2 1 Domain of unknown function (DUF4407) Reo_sigmaC PF04582.10 001110818.1_39725001_2 - 0.00078 18.8 14.4 0.069 12.4 3.3 2.7 1 1 2 3 3 3 2 Reovirus sigma C capsid protein CENP-F_leu_zip PF10473.7 001110818.1_39725001_2 - 0.0021 17.9 32.9 0.15 12.0 6.8 3.4 1 1 3 4 4 4 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Golgin_A5 PF09787.7 001110818.1_39725001_2 - 0.0066 15.8 34.7 0.063 12.6 12.7 2.7 1 1 2 3 3 3 2 Golgin subfamily A member 5 Cast PF10174.7 001110818.1_39725001_2 - 0.0099 14.0 28.1 0.21 9.7 5.3 2.1 1 1 1 2 2 2 2 RIM-binding protein of the cytomatrix active zone She9_MDM33 PF05546.9 001110818.1_39725001_2 - 0.012 15.3 13.8 0.25 11.0 1.7 2.9 2 1 0 2 2 2 0 She9 / Mdm33 family Tropomyosin_1 PF12718.5 001110818.1_39725001_2 - 0.027 14.4 34.6 0.026 14.5 11.7 3.7 2 1 2 4 4 4 0 Tropomyosin like IncA PF04156.12 001110818.1_39725001_2 - 0.033 13.8 42.9 0.82 9.3 15.4 3.5 1 1 2 3 3 3 0 IncA protein ADIP PF11559.6 001110818.1_39725001_2 - 0.037 14.0 37.4 0.016 15.2 8.6 4.0 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding DUF745 PF05335.11 001110818.1_39725001_2 - 0.042 13.5 22.5 0.27 10.8 10.2 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF745) XhlA PF10779.7 001110818.1_39725001_2 - 0.096 12.7 19.7 0.7 10.0 0.1 4.9 4 1 2 6 6 6 0 Haemolysin XhlA JIP_LZII PF16471.3 001110818.1_39725001_2 - 0.13 12.3 26.5 0.29 11.2 0.7 5.9 4 2 2 6 6 6 0 JNK-interacting protein leucine zipper II DUF1664 PF07889.10 001110818.1_39725001_2 - 0.16 11.8 23.2 0.2 11.5 1.1 4.1 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) DUF5082 PF16888.3 001110818.1_39725001_2 - 0.18 12.0 35.0 0.16 12.2 7.2 4.3 2 2 2 4 4 4 0 Domain of unknown function (DUF5082) DUF948 PF06103.9 001110818.1_39725001_2 - 0.19 11.9 17.4 0.21 11.7 1.1 4.0 3 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) GARP PF16731.3 001110818.1_39725001_2 - 0.64 9.5 8.8 0.048 13.2 1.2 2.5 3 0 0 3 3 2 0 Glutamic acid/alanine-rich protein of Trypanosoma CLZ PF16526.3 001110818.1_39725001_2 - 0.7 10.1 23.3 0.69 10.2 2.5 5.2 3 2 2 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF883 PF05957.11 001110818.1_39725001_2 - 0.72 10.4 16.1 0.099 13.1 3.4 3.8 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) SAT PF16073.3 001110818.1_39725001_2 - 0.88 9.0 6.1 0.14 11.6 0.5 2.4 2 1 1 3 3 3 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Baculo_PEP_C PF04513.10 001110818.1_39725001_2 - 0.96 9.4 30.6 0.28 11.1 6.7 4.2 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Jnk-SapK_ap_N PF09744.7 001110818.1_39725001_2 - 1.4 9.0 35.6 0.19 11.8 8.2 3.2 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 CHDCT2 PF08074.9 001110818.1_39725001_2 - 1.4 8.9 18.9 3.5 7.6 0.5 3.8 1 1 1 3 3 3 0 CHDCT2 (NUC038) domain MukF_M PF17192.2 001110818.1_39725001_2 - 1.7 8.3 20.4 3.1 7.4 7.2 2.7 1 1 0 2 2 2 0 MukF middle domain rve_3 PF13683.4 001110818.1_39725001_2 - 1.7 8.3 3.3 3.5 7.3 0.2 2.7 2 1 1 3 3 3 0 Integrase core domain TSC22 PF01166.16 001110818.1_39725001_2 - 1.8 8.8 18.2 3.5 7.9 0.7 4.9 4 1 1 5 5 5 0 TSC-22/dip/bun family Fib_alpha PF08702.8 001110818.1_39725001_2 - 1.8 8.6 38.5 0.5 10.4 6.6 4.0 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family DUF1192 PF06698.9 001110818.1_39725001_2 - 2.2 8.3 7.7 1.2 9.1 0.6 3.6 4 0 0 4 4 3 0 Protein of unknown function (DUF1192) Lebercilin PF15619.4 001110818.1_39725001_2 - 3.3 7.2 35.9 2.5 7.6 20.5 3.3 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease GAS PF13851.4 001110818.1_39725001_2 - 4.9 6.3 40.8 2.4 7.3 14.8 3.4 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF342 PF03961.11 001110818.1_39725001_2 - 5 5.5 30.8 0.8 8.1 5.6 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF342) PEP-utilisers_N PF05524.11 001110818.1_39725001_2 - 5.1 7.2 6.8 1.5e+02 2.4 5.3 3.6 3 1 0 3 3 3 0 PEP-utilising enzyme, N-terminal ApoO PF09769.7 001110818.1_39725001_2 - 5.9 6.7 10.6 2 8.3 0.2 3.7 3 1 0 4 4 4 0 Apolipoprotein O DUF4618 PF15397.4 001110818.1_39725001_2 - 7 5.9 36.8 0.2 10.9 12.7 3.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4618) DUF1451 PF07295.9 001110818.1_39725001_2 - 8.1 6.4 18.8 3.7 7.4 3.2 2.8 2 1 0 2 2 2 0 Zinc-ribbon containing domain bZIP_1 PF00170.19 001110818.1_39725001_2 - 9.3 6.3 22.4 0.094 12.7 0.4 4.6 5 0 0 5 5 4 0 bZIP transcription factor Cep57_MT_bd PF06657.11 001110818.1_39725001_2 - 9.7 6.6 19.5 0.91 9.9 3.6 4.6 3 2 1 4 4 4 0 Centrosome microtubule-binding domain of Cep57 p450 PF00067.20 001081805.2_21026001_2 - 2.3e-95 319.9 1.3 3e-95 319.5 1.3 1.1 1 0 0 1 1 1 1 Cytochrome P450 Septin PF00735.16 022616.2_45725001_3 - 5.3e-123 409.6 0.1 5.3e-123 409.6 0.1 1.6 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.21 022616.2_45725001_3 - 1.1e-06 28.6 0.1 4.5e-06 26.6 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.14 022616.2_45725001_3 - 1.3e-05 25.0 8.9 0.00038 20.3 0.0 3.3 3 0 0 3 3 3 2 Protein of unknown function, DUF258 AIG1 PF04548.14 022616.2_45725001_3 - 0.0037 16.5 0.0 0.0037 16.5 0.0 2.1 2 0 0 2 2 1 1 AIG1 family Exonuc_VII_L PF02601.13 022616.2_45725001_3 - 0.016 14.6 10.1 0.023 14.1 10.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_22 PF13401.4 022616.2_45725001_3 - 0.021 14.9 0.0 0.067 13.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 022616.2_45725001_3 - 0.028 14.6 0.4 0.067 13.4 0.0 1.7 2 0 0 2 2 1 0 AAA ATPase domain Ras PF00071.20 022616.2_45725001_3 - 0.051 13.0 1.6 0.059 12.8 0.0 1.9 2 0 0 2 2 2 0 Ras family AAA_29 PF13555.4 022616.2_45725001_3 - 0.065 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.16 022616.2_45725001_3 - 0.079 12.3 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B ABC_tran PF00005.25 022616.2_45725001_3 - 0.085 13.2 0.0 0.085 13.2 0.0 2.4 2 0 0 2 2 2 0 ABC transporter GTP_EFTU PF00009.25 022616.2_45725001_3 - 0.11 11.9 9.1 1.8 7.9 0.1 3.8 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 022616.2_45725001_3 - 0.17 11.0 0.0 0.17 11.0 0.0 2.8 3 0 0 3 3 2 0 Gtr1/RagA G protein conserved region Fez1 PF06818.13 022616.2_45725001_3 - 2.1 8.6 27.1 0.14 12.4 22.1 1.5 2 0 0 2 2 2 0 Fez1 DUF87 PF01935.15 022616.2_45725001_3 - 6.5 6.6 9.6 74 3.1 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function DUF87 V-set PF07686.15 001359812.1_32925001_1 - 7.2e-11 42.1 0.1 1.7e-10 40.9 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain SIT PF15330.4 001359812.1_32925001_1 - 1.2e-07 32.0 1.1 3.9e-07 30.3 1.1 1.9 1 1 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT ig PF00047.23 001359812.1_32925001_1 - 0.013 15.5 0.2 0.36 10.9 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin domain CCDC14 PF15254.4 001101298.2_06525001_1 - 6e-07 28.4 3.1 7.7e-07 28.1 3.1 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 14 CCDC14 PF15254.4 001101298.2_06525001_2 - 1.7e-169 566.3 6.3 2e-169 566.0 6.3 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 14 RE_HaeIII PF09556.8 001101298.2_06525001_2 - 0.026 13.5 0.0 0.041 12.8 0.0 1.2 1 0 0 1 1 1 0 HaeIII restriction endonuclease SMN PF06003.10 001101298.2_06525001_2 - 0.042 13.0 1.7 0.35 10.0 0.9 2.1 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) PDZ PF00595.22 001194930.2_39729001_2 - 9.7e-48 160.3 1.5 6e-17 61.6 0.1 4.3 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001194930.2_39729001_2 - 5.8e-13 48.8 0.0 0.058 13.6 0.0 4.5 4 0 0 4 4 4 4 PDZ domain PNMA PF14893.4 001348394.1_39726001_1 - 5.4e-133 443.3 0.0 6.6e-133 443.0 0.0 1.1 1 0 0 1 1 1 1 PNMA Septin PF00735.16 001197121.1_39725001_3 - 4.8e-123 409.7 0.1 4.8e-123 409.7 0.1 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.21 001197121.1_39725001_3 - 1.4e-06 28.2 0.1 4.2e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.14 001197121.1_39725001_3 - 9.9e-06 25.4 8.2 0.00029 20.7 0.0 3.3 3 0 0 3 3 3 2 Protein of unknown function, DUF258 AIG1 PF04548.14 001197121.1_39725001_3 - 0.0035 16.6 0.0 0.0035 16.6 0.0 2.1 2 0 0 2 2 1 1 AIG1 family AAA_22 PF13401.4 001197121.1_39725001_3 - 0.021 15.0 0.0 0.063 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain Ras PF00071.20 001197121.1_39725001_3 - 0.022 14.2 0.0 0.056 12.9 0.0 1.7 1 0 0 1 1 1 0 Ras family AAA_16 PF13191.4 001197121.1_39725001_3 - 0.023 14.9 0.0 0.064 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Exonuc_VII_L PF02601.13 001197121.1_39725001_3 - 0.027 13.9 9.2 0.04 13.4 9.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_29 PF13555.4 001197121.1_39725001_3 - 0.066 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.25 001197121.1_39725001_3 - 0.07 12.5 8.5 1.7 8.0 0.1 3.8 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.16 001197121.1_39725001_3 - 0.077 12.4 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B ABC_tran PF00005.25 001197121.1_39725001_3 - 0.077 13.4 0.0 0.077 13.4 0.0 2.3 2 0 0 2 2 2 0 ABC transporter Gtr1_RagA PF04670.10 001197121.1_39725001_3 - 0.15 11.2 7.9 0.17 11.1 0.0 2.6 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region DUF87 PF01935.15 001197121.1_39725001_3 - 7.9 6.3 9.2 71 3.2 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function DUF87 Methyltransf_3 PF01596.15 001136102.1_29625001_3 - 6.2e-14 51.6 0.0 8.8e-14 51.0 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.4 001136102.1_29625001_3 - 9.6e-10 39.3 0.1 2.5e-09 38.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain LRR_8 PF13855.4 001136102.1_29625001_3 - 8.2e-07 28.6 1.8 8.2e-07 28.6 1.8 2.1 2 0 0 2 2 2 1 Leucine rich repeat LRR_9 PF14580.4 001136102.1_29625001_3 - 1e-05 25.0 0.1 2.8e-05 23.6 0.0 1.7 1 1 1 2 2 2 1 Leucine-rich repeat PCMT PF01135.17 001136102.1_29625001_3 - 0.0046 16.6 0.0 0.0069 16.0 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) LRR_4 PF12799.5 001136102.1_29625001_3 - 0.0057 16.9 10.7 0.034 14.4 1.0 3.3 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) Methyltransf_31 PF13847.4 001136102.1_29625001_3 - 0.037 13.7 0.0 0.065 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain E1-E2_ATPase PF00122.18 001253834.1_32929001_1 - 3.2e-60 203.0 1.0 7e-60 201.9 1.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 001253834.1_32929001_1 - 2.1e-45 154.5 3.9 2.1e-45 154.5 3.9 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.24 001253834.1_32929001_1 - 3.1e-21 76.5 2.4 1e-20 74.8 2.4 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 001253834.1_32929001_1 - 1.6e-17 62.8 0.1 3.1e-17 61.8 0.1 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.4 001253834.1_32929001_1 - 2.8e-16 59.2 0.1 4.2e-15 55.5 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.10 001253834.1_32929001_1 - 0.00084 19.0 3.1 0.0017 18.0 3.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase adh_short PF00106.23 001081786.1_21023001_1 - 7.2e-57 191.9 0.1 8.9e-57 191.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001081786.1_21023001_1 - 2e-45 155.0 0.0 2.6e-45 154.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001081786.1_21023001_1 - 1.1e-09 38.3 0.1 1.6e-09 37.8 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 001081786.1_21023001_1 - 0.00029 20.2 0.1 0.0004 19.8 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 001081786.1_21023001_1 - 0.0013 18.0 0.0 0.0018 17.5 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Lectin_leg-like PF03388.11 001081786.1_21023001_1 - 0.01 15.1 0.0 0.016 14.4 0.0 1.2 1 0 0 1 1 1 0 Legume-like lectin family Guanylate_cyc PF00211.18 001107239.1_45727001_1 - 2.1e-129 428.2 0.5 6.5e-66 221.3 0.1 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.3 001107239.1_45727001_1 - 4.6e-27 95.1 0.0 4.6e-27 95.1 0.0 2.5 3 0 0 3 3 3 1 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF1053 PF06327.12 001107239.1_45727001_1 - 0.012 16.0 0.4 0.023 15.1 0.4 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) HNOBA PF07701.12 001107239.1_45727001_1 - 0.041 13.2 1.0 0.38 10.0 0.2 2.3 2 0 0 2 2 2 0 Heme NO binding associated Glyco_transf_7C PF02709.12 001039964.1_39723001_2 - 4.4e-27 93.4 0.2 8e-27 92.6 0.2 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_transf_7N PF13733.4 001039964.1_39723001_2 - 6.1e-23 80.8 0.0 1e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_tranf_2_2 PF10111.7 001039964.1_39723001_2 - 0.0061 15.9 0.0 2.7 7.3 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Filament PF00038.19 001280067.1_39725001_3 - 6.1e-117 390.5 37.9 7.4e-117 390.2 37.9 1.1 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001280067.1_39725001_3 - 2.2e-44 151.3 44.3 2.2e-44 151.3 44.3 2.9 2 1 0 2 2 1 1 Keratin type II head TPR_MLP1_2 PF07926.10 001280067.1_39725001_3 - 7.8e-06 25.8 30.7 0.0011 19.0 0.3 3.8 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein AAA_13 PF13166.4 001280067.1_39725001_3 - 0.00016 20.4 18.1 0.00016 20.4 18.1 1.6 1 1 0 1 1 1 1 AAA domain CENP-F_leu_zip PF10473.7 001280067.1_39725001_3 - 0.00053 19.9 27.5 0.0092 15.9 8.8 3.3 1 1 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.9 001280067.1_39725001_3 - 0.00054 18.8 34.0 0.023 13.5 8.3 3.0 1 1 2 3 3 3 3 Spc7 kinetochore protein Alanine_zipper PF11839.6 001280067.1_39725001_3 - 0.0026 17.8 6.0 0.0026 17.8 6.0 1.9 2 0 0 2 2 1 1 Alanine-zipper, major outer membrane lipoprotein ATG16 PF08614.9 001280067.1_39725001_3 - 0.0056 16.8 26.9 0.32 11.0 4.2 2.6 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) Reo_sigmaC PF04582.10 001280067.1_39725001_3 - 0.025 13.9 5.6 0.51 9.6 0.4 2.5 1 1 0 2 2 2 0 Reovirus sigma C capsid protein Taxilin PF09728.7 001280067.1_39725001_3 - 0.055 12.6 29.8 0.75 8.9 29.8 2.7 1 1 0 1 1 1 0 Myosin-like coiled-coil protein DUF745 PF05335.11 001280067.1_39725001_3 - 0.075 12.6 16.4 0.082 12.5 10.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Golgin_A5 PF09787.7 001280067.1_39725001_3 - 0.091 12.1 29.5 0.026 13.8 11.4 2.9 1 1 3 4 4 4 0 Golgin subfamily A member 5 DUF5082 PF16888.3 001280067.1_39725001_3 - 0.15 12.3 23.8 0.33 11.2 1.0 4.0 1 1 3 4 4 4 0 Domain of unknown function (DUF5082) Baculo_PEP_C PF04513.10 001280067.1_39725001_3 - 0.2 11.6 19.8 0.039 13.8 1.2 4.1 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Ax_dynein_light PF10211.7 001280067.1_39725001_3 - 0.32 10.8 28.5 1.3 8.8 9.9 3.1 1 1 2 3 3 3 0 Axonemal dynein light chain ADIP PF11559.6 001280067.1_39725001_3 - 0.39 10.7 28.0 0.27 11.2 11.2 3.5 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Tropomyosin_1 PF12718.5 001280067.1_39725001_3 - 0.42 10.6 29.4 0.027 14.5 12.6 3.4 2 1 1 3 3 3 0 Tropomyosin like DUF883 PF05957.11 001280067.1_39725001_3 - 0.54 10.7 16.1 2 8.9 5.8 3.7 2 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) IncA PF04156.12 001280067.1_39725001_3 - 0.56 9.8 29.1 0.91 9.2 14.9 3.1 1 1 1 2 2 2 0 IncA protein DUF3584 PF12128.6 001280067.1_39725001_3 - 0.79 7.0 30.5 0.24 8.7 15.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF2746 PF10874.6 001280067.1_39725001_3 - 0.88 9.9 2.7 0.9 9.8 0.3 2.2 2 0 0 2 2 1 0 Protein of unknown function (DUF2746) Lebercilin PF15619.4 001280067.1_39725001_3 - 1.1 8.8 31.8 0.23 11.0 14.7 2.5 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Jnk-SapK_ap_N PF09744.7 001280067.1_39725001_3 - 1.1 9.4 29.3 0.091 12.8 2.5 3.5 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 ATPase PF06745.11 001280067.1_39725001_3 - 1.1 8.4 5.4 11 5.2 0.8 2.5 2 1 0 2 2 2 0 KaiC DUF3502 PF12010.6 001280067.1_39725001_3 - 1.2 9.6 5.3 9.5 6.8 5.3 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3502) APG6 PF04111.10 001280067.1_39725001_3 - 2.2 7.5 33.6 0.089 12.0 10.2 3.0 1 1 2 3 3 3 0 Autophagy protein Apg6 COG5 PF10392.7 001280067.1_39725001_3 - 2.4 8.2 10.4 0.085 12.9 2.5 2.5 2 2 2 4 4 2 0 Golgi transport complex subunit 5 WXG100 PF06013.10 001280067.1_39725001_3 - 2.6 8.2 8.2 58 3.9 5.6 3.9 2 1 0 2 2 2 0 Proteins of 100 residues with WXG ISG65-75 PF11727.6 001280067.1_39725001_3 - 2.8 7.0 11.3 0.56 9.2 5.6 2.1 2 0 0 2 2 2 0 Invariant surface glycoprotein DUF1451 PF07295.9 001280067.1_39725001_3 - 2.9 7.8 15.0 4.3 7.2 3.7 2.7 2 1 0 2 2 2 0 Zinc-ribbon containing domain Tup_N PF08581.8 001280067.1_39725001_3 - 3.2 8.0 26.5 2.6 8.3 0.4 5.5 2 2 5 7 7 7 0 Tup N-terminal DUF342 PF03961.11 001280067.1_39725001_3 - 3.4 6.0 21.4 5.2 5.4 10.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF342) DASH_Duo1 PF08651.8 001280067.1_39725001_3 - 3.4 7.4 10.4 2.5 7.8 0.9 3.9 3 1 0 4 4 4 0 DASH complex subunit Duo1 CHDCT2 PF08074.9 001280067.1_39725001_3 - 3.7 7.6 15.2 5 7.1 1.3 2.7 1 1 2 3 3 3 0 CHDCT2 (NUC038) domain DUF1664 PF07889.10 001280067.1_39725001_3 - 4.5 7.1 17.6 1.8 8.4 2.1 4.1 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.8 001280067.1_39725001_3 - 4.7 7.2 26.2 0.78 9.8 4.5 3.9 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family Cob_adeno_trans PF01923.16 001280067.1_39725001_3 - 5.1 7.1 9.1 11 6.0 6.6 2.4 1 1 1 2 2 2 0 Cobalamin adenosyltransferase DUF1192 PF06698.9 001280067.1_39725001_3 - 5.1 7.1 6.7 1.1 9.3 0.2 3.0 3 1 0 3 3 2 0 Protein of unknown function (DUF1192) Vps51 PF08700.9 001280067.1_39725001_3 - 5.6 7.0 11.7 0.45 10.5 1.3 3.7 3 1 1 4 4 4 0 Vps51/Vps67 DUF948 PF06103.9 001280067.1_39725001_3 - 6 7.1 13.5 2.6 8.2 1.7 4.1 3 2 2 5 5 4 0 Bacterial protein of unknown function (DUF948) Med9 PF07544.11 001280067.1_39725001_3 - 6 6.9 11.0 2.5 8.1 5.8 2.9 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Wtap PF17098.3 001280067.1_39725001_3 - 6.8 6.5 20.6 0.072 12.9 1.2 3.8 2 2 1 3 3 3 0 WTAP/Mum2p family Transposase_22 PF02994.12 001280067.1_39725001_3 - 7.4 5.2 20.5 0.094 11.4 8.3 2.2 1 1 1 2 2 2 0 L1 transposable element Virulence_fact PF13769.4 001280067.1_39725001_3 - 8 6.5 10.2 5.6 7.0 0.1 3.3 3 1 1 4 4 3 0 Virulence factor RPW8 PF05659.9 001280067.1_39725001_3 - 9.5 5.8 12.2 12 5.4 2.4 3.4 2 2 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF4407 PF14362.4 001280067.1_39725001_3 - 9.6 5.3 23.4 7.1e+03 -4.1 23.4 2.5 1 1 0 1 1 0 0 Domain of unknown function (DUF4407) IL2 PF00715.15 001085433.2_21022001_2 - 8.1e-72 239.8 5.9 1.1e-71 239.4 5.9 1.1 1 0 0 1 1 1 1 Interleukin 2 Baculo_PEP_C PF04513.10 001085433.2_21022001_2 - 0.025 14.5 1.7 0.032 14.1 1.7 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3373 PF11853.6 001085433.2_21022001_2 - 1.6 7.2 3.3 2.9 6.4 3.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) Filament PF00038.19 001098569.1_39725001_1 - 1.1e-108 363.4 36.5 1.3e-108 363.2 36.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001098569.1_39725001_1 - 5.8e-34 117.5 83.1 5.8e-34 117.5 83.1 3.3 3 1 0 3 3 2 1 Keratin type II head Spc7 PF08317.9 001098569.1_39725001_1 - 7e-05 21.7 33.5 0.0049 15.7 11.2 3.0 1 1 2 3 3 3 2 Spc7 kinetochore protein TPR_MLP1_2 PF07926.10 001098569.1_39725001_1 - 0.00031 20.7 33.3 0.0022 17.9 2.8 3.6 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein AAA_13 PF13166.4 001098569.1_39725001_1 - 0.0012 17.5 19.5 0.0012 17.5 19.5 1.9 2 1 0 2 2 2 1 AAA domain FlgN PF05130.10 001098569.1_39725001_1 - 0.002 18.5 11.8 0.002 18.5 11.8 2.5 2 0 0 2 2 2 1 FlgN protein SlyX PF04102.10 001098569.1_39725001_1 - 0.017 15.6 0.8 0.017 15.6 0.8 4.8 4 1 2 6 6 4 0 SlyX HrpB7 PF09486.8 001098569.1_39725001_1 - 0.02 15.2 11.6 0.51 10.6 0.1 2.5 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Reo_sigmaC PF04582.10 001098569.1_39725001_1 - 0.055 12.7 12.3 0.021 14.1 2.2 2.9 1 1 2 3 3 3 0 Reovirus sigma C capsid protein DUF1192 PF06698.9 001098569.1_39725001_1 - 0.076 12.9 6.0 0.13 12.2 0.5 3.3 3 0 0 3 3 2 0 Protein of unknown function (DUF1192) Alanine_zipper PF11839.6 001098569.1_39725001_1 - 0.29 11.3 8.2 0.03 14.5 2.5 2.2 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein Jnk-SapK_ap_N PF09744.7 001098569.1_39725001_1 - 0.38 10.8 30.4 2.4 8.2 8.5 3.6 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 DUF745 PF05335.11 001098569.1_39725001_1 - 0.4 10.3 21.4 0.23 11.0 10.1 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF745) CENP-F_leu_zip PF10473.7 001098569.1_39725001_1 - 0.43 10.5 29.9 0.22 11.4 9.4 3.5 2 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fib_alpha PF08702.8 001098569.1_39725001_1 - 0.69 10.0 32.8 0.13 12.4 6.1 4.2 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family ADIP PF11559.6 001098569.1_39725001_1 - 1.1 9.2 26.4 0.32 10.9 7.2 3.9 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.4 001098569.1_39725001_1 - 1.3 8.1 22.0 0.59 9.3 2.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DASH_Duo1 PF08651.8 001098569.1_39725001_1 - 1.4 8.6 9.9 1.9 8.2 0.2 4.2 4 0 0 4 4 4 0 DASH complex subunit Duo1 CHDCT2 PF08074.9 001098569.1_39725001_1 - 1.7 8.7 18.6 1.5 8.8 1.9 3.1 1 1 2 3 3 3 0 CHDCT2 (NUC038) domain Baculo_PEP_C PF04513.10 001098569.1_39725001_1 - 2.4 8.1 21.4 0.32 10.9 2.3 3.4 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.9 001098569.1_39725001_1 - 4 7.6 11.0 2.6 8.2 1.0 3.7 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Cep57_MT_bd PF06657.11 001098569.1_39725001_1 - 4.8 7.6 17.3 0.066 13.5 2.1 3.9 2 2 3 5 5 5 0 Centrosome microtubule-binding domain of Cep57 Golgin_A5 PF09787.7 001098569.1_39725001_1 - 5.2 6.3 31.6 2.4 7.4 11.4 3.3 1 1 3 4 4 4 0 Golgin subfamily A member 5 Tropomyosin_1 PF12718.5 001098569.1_39725001_1 - 5.4 7.0 31.2 0.25 11.3 11.2 3.3 3 0 0 3 3 3 0 Tropomyosin like IncA PF04156.12 001098569.1_39725001_1 - 6.2 6.4 36.2 9.8 5.8 19.8 3.7 1 1 1 2 2 2 0 IncA protein DUF883 PF05957.11 001098569.1_39725001_1 - 8.6 6.9 14.5 0.36 11.3 2.9 3.4 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) ATP-synt_ab_N PF02874.21 001098569.1_39725001_2 - 0.08 13.3 4.8 0.11 12.9 1.6 2.5 1 1 1 2 2 2 0 ATP synthase alpha/beta family, beta-barrel domain Connexin PF00029.17 001256971.1_21024001_1 - 6.4e-93 310.5 0.3 1e-92 309.9 0.3 1.3 1 0 0 1 1 1 1 Connexin Filament PF00038.19 001328291.1_39724001_2 - 1.9e-104 349.5 40.8 2.2e-104 349.3 40.8 1.0 1 0 0 1 1 1 1 Intermediate filament protein Baculo_PEP_C PF04513.10 001328291.1_39724001_2 - 0.15 12.0 21.5 2.5 8.0 2.0 3.3 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF342 PF03961.11 001328291.1_39724001_2 - 3.6 6.0 21.5 1.7 7.0 11.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF342) ADIP PF11559.6 001328291.1_39724001_2 - 3.8 7.4 35.6 0.2 11.6 13.9 3.3 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding DUF3373 PF11853.6 001328291.1_39724001_2 - 6 5.4 9.8 64 2.0 9.8 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) Fib_alpha PF08702.8 001328291.1_39724001_2 - 7.2 6.7 29.7 4.3 7.4 13.9 3.5 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family zf-C4H2 PF10146.7 001328291.1_39724001_2 - 7.2 6.7 27.0 1.2 9.2 2.1 3.4 1 1 2 3 3 3 0 Zinc finger-containing protein Homeobox PF00046.27 001135625.3_39724001_3 - 2.8e-21 75.0 5.2 4.8e-21 74.2 5.2 1.4 1 0 0 1 1 1 1 Homeobox domain Pacs-1 PF10254.7 001135625.3_39724001_3 - 0.17 10.7 0.3 0.24 10.2 0.3 1.1 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein Hat1_N PF10394.7 001309212.1_21024001_3 - 1.6e-43 148.6 1.6 2e-43 148.3 0.1 1.8 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_10 PF13673.5 001309212.1_21024001_3 - 0.044 13.6 0.0 0.14 12.0 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 001309212.1_21024001_3 - 0.052 13.9 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain 7tm_1 PF00001.19 001328288.1_39724001_2 - 1.6e-12 47.1 0.0 2.3e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-C2H2_assoc PF16606.3 001328288.1_39724001_2 - 0.67 10.1 3.3 7.3 6.8 0.2 2.7 2 0 0 2 2 2 0 Unstructured conserved, between two C2H2-type zinc-fingers tRNA-synt_2b PF00587.23 001257103.1_21023001_1 - 1.4e-34 119.5 0.0 2e-34 119.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.18 001257103.1_21023001_1 - 1.5e-06 28.1 0.0 2.6e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Anticodon binding domain Auto_anti-p27 PF06677.10 001257103.1_21023001_1 - 0.23 11.5 1.7 2.2 8.4 0.0 3.0 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) IL12 PF03039.12 001082511.2_21022001_1 - 4.2e-118 392.3 3.2 4.8e-118 392.1 3.2 1.0 1 0 0 1 1 1 1 Interleukin-12 alpha subunit Filament PF00038.19 001098551.1_39724001_2 - 1.1e-106 356.9 38.1 1.2e-106 356.6 38.1 1.0 1 0 0 1 1 1 1 Intermediate filament protein zf-C4H2 PF10146.7 001098551.1_39724001_2 - 0.0025 18.0 19.1 0.26 11.4 4.0 3.6 1 1 1 2 2 2 1 Zinc finger-containing protein Lzipper-MIP1 PF14389.4 001098551.1_39724001_2 - 0.0082 16.2 5.5 0.0082 16.2 5.5 4.0 3 2 0 3 3 3 1 Leucine-zipper of ternary complex factor MIP1 Gp58 PF07902.9 001098551.1_39724001_2 - 0.042 12.2 10.2 0.058 11.7 10.2 1.2 1 0 0 1 1 1 0 gp58-like protein NYD-SP28_assoc PF14775.4 001098551.1_39724001_2 - 0.13 12.2 12.6 1.5 8.8 1.2 4.1 3 0 0 3 3 3 0 Sperm tail C-terminal domain Baculo_PEP_C PF04513.10 001098551.1_39724001_2 - 0.17 11.8 21.3 0.44 10.5 13.3 3.2 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_MLP1_2 PF07926.10 001098551.1_39724001_2 - 0.3 11.0 39.1 0.24 11.4 4.2 4.0 2 2 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF5082 PF16888.3 001098551.1_39724001_2 - 0.57 10.4 22.2 0.095 12.9 7.6 3.2 2 1 0 3 3 3 0 Domain of unknown function (DUF5082) Fib_alpha PF08702.8 001098551.1_39724001_2 - 3.5 7.7 25.4 1.5 8.8 11.8 3.5 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family DUF3373 PF11853.6 001098551.1_39724001_2 - 5.4 5.5 8.3 61 2.0 8.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) Prefoldin PF02996.15 001098551.1_39724001_2 - 5.4 6.8 20.0 2 8.2 1.3 4.7 4 1 0 4 4 4 0 Prefoldin subunit Uso1_p115_C PF04871.11 001098551.1_39724001_2 - 6.6 7.0 25.5 0.97 9.7 7.1 3.2 2 2 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Actin PF00022.17 001009945.1_39724001_3 - 7.4e-151 502.2 0.0 2e-150 500.8 0.0 1.6 1 1 0 1 1 1 1 Actin Transket_pyr PF02779.22 031379.2_32925001_2 - 1.9e-36 125.3 0.0 5.2e-36 123.8 0.0 1.8 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.18 031379.2_32925001_2 - 1.8e-29 102.0 0.4 7.9e-29 99.9 0.3 2.0 2 0 0 2 2 2 1 Transketolase, C-terminal domain Transketolase_N PF00456.19 031379.2_32925001_2 - 1.1e-19 70.5 0.0 1.3e-16 60.3 0.0 2.3 1 1 1 2 2 2 2 Transketolase, thiamine diphosphate binding domain E1_dh PF00676.18 031379.2_32925001_2 - 1.8e-06 27.0 0.1 3.4e-06 26.1 0.1 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.4 031379.2_32925001_2 - 0.024 13.7 0.0 0.3 10.1 0.0 2.2 1 1 1 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase YjeF_N PF03853.13 031379.2_32925001_2 - 0.096 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus DUF4870 PF09685.8 009389.2_32929001_1 - 0.19 11.7 0.3 0.33 10.9 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4870) TLE_N PF03920.13 009389.2_32929001_2 - 3.3e-71 237.3 8.9 4.6e-71 236.9 8.9 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.30 009389.2_32929001_2 - 4.5e-14 52.5 19.0 0.038 14.7 1.3 7.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 009389.2_32929001_2 - 9e-06 25.8 0.0 1.3 9.3 0.0 3.9 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 009389.2_32929001_2 - 0.021 14.0 0.0 3.3 6.8 0.0 2.3 2 0 0 2 2 2 0 WD40-like domain HALZ PF02183.16 009389.2_32929001_2 - 0.03 14.4 0.7 0.064 13.3 0.7 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper TFIIA PF03153.11 009389.2_32929001_2 - 2.1 8.1 12.2 2.2 8.0 11.1 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DnaJ PF00226.29 001280413.1_39724001_1 - 1.9e-26 91.8 4.8 2.9e-26 91.2 4.8 1.3 1 0 0 1 1 1 1 DnaJ domain UIM PF02809.18 001280413.1_39724001_1 - 0.0014 18.3 8.5 0.0016 18.1 4.0 2.5 2 0 0 2 2 2 1 Ubiquitin interaction motif Filament PF00038.19 001009079.1_39724001_1 - 5.1e-98 328.4 29.5 6e-98 328.1 29.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein DUF5082 PF16888.3 001009079.1_39724001_1 - 0.0084 16.3 4.2 0.0084 16.3 4.2 2.8 2 1 1 3 3 3 1 Domain of unknown function (DUF5082) Jnk-SapK_ap_N PF09744.7 001009079.1_39724001_1 - 0.029 14.5 27.8 0.07 13.2 8.4 3.4 2 1 0 3 3 3 0 JNK_SAPK-associated protein-1 DUF1664 PF07889.10 001009079.1_39724001_1 - 0.77 9.6 12.4 2 8.3 1.0 3.4 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) DUF3373 PF11853.6 001009079.1_39724001_1 - 1.6 7.3 6.8 22 3.5 6.8 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) TPR_MLP1_2 PF07926.10 001009079.1_39724001_1 - 1.6 8.7 29.4 0.28 11.1 4.1 3.9 2 2 2 4 4 4 0 TPR/MLP1/MLP2-like protein CHDCT2 PF08074.9 001009079.1_39724001_1 - 1.9 8.5 8.5 0.096 12.7 2.7 1.8 2 1 0 2 2 2 0 CHDCT2 (NUC038) domain Endothelin PF00322.15 001101696.1_37924001_3 - 1.9e-22 78.4 13.5 6.1e-21 73.6 3.6 2.6 2 0 0 2 2 2 2 Endothelin family DAGK_cat PF00781.22 145475.4_32929001_2 - 8.3e-29 99.6 0.1 1.2e-28 99.1 0.1 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain zf-C4 PF00105.16 019328.3_45726001_1 - 3e-31 107.6 17.5 6e-31 106.6 17.5 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 019328.3_45726001_1 - 2.7e-30 105.4 0.0 4.7e-30 104.6 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor ABC2_membrane PF01061.22 181381.2_45725001_1 - 3.6e-39 134.2 24.1 3.6e-39 134.2 24.1 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.25 181381.2_45725001_1 - 2.9e-21 76.3 0.0 4.3e-21 75.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 181381.2_45725001_1 - 1.5e-05 24.9 0.5 0.17 11.6 0.1 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.17 181381.2_45725001_1 - 3.9e-05 23.1 0.1 0.00051 19.4 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.4 181381.2_45725001_1 - 0.0013 19.2 0.2 0.0029 18.0 0.2 1.5 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.14 181381.2_45725001_1 - 0.0078 16.0 0.0 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC2_membrane_3 PF12698.5 181381.2_45725001_1 - 0.021 13.8 26.4 0.013 14.5 22.3 2.2 1 1 1 2 2 2 0 ABC-2 family transporter protein AAA_29 PF13555.4 181381.2_45725001_1 - 0.075 12.6 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF2070 PF09843.7 181381.2_45725001_1 - 3.2 5.8 16.9 5 5.2 16.9 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) HLH PF00010.24 001243227.1_26229001_3 - 2.5e-11 43.2 1.0 5.9e-11 42.0 1.0 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.12 001243227.1_26229001_3 - 5.3 5.1 10.0 7.8 4.5 10.0 1.1 1 0 0 1 1 1 0 CDC45-like protein BTG PF07742.10 006763.2_26226001_3 - 1.1e-40 137.9 0.0 1.7e-40 137.4 0.0 1.2 1 0 0 1 1 1 1 BTG family Transglut_C PF00927.20 001161714.1_32926001_1 - 8.4e-41 138.3 0.0 9.8e-21 73.8 0.0 2.4 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_N PF00868.18 001161714.1_32926001_1 - 1.2e-31 109.4 0.0 2.5e-31 108.3 0.0 1.6 1 0 0 1 1 1 1 Transglutaminase family Transglut_core PF01841.17 001161714.1_32926001_1 - 1.9e-13 50.7 0.2 4.7e-13 49.4 0.2 1.7 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF11 PF01345.16 001161714.1_32926001_1 - 0.046 13.9 0.7 12 6.1 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function DUF11 CK_II_beta PF01214.16 001035238.2_45722001_2 - 2.3e-86 288.2 0.0 2.7e-86 287.9 0.0 1.0 1 0 0 1 1 1 1 Casein kinase II regulatory subunit CCDC24 PF15669.3 001035238.2_45722001_2 - 0.13 12.0 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Neuregulin PF02158.13 001271118.1_45728001_1 - 1.6e-187 623.7 21.2 2.4e-187 623.1 21.2 1.2 1 0 0 1 1 1 1 Neuregulin family EGF PF00008.25 001271118.1_45728001_1 - 0.0023 18.0 3.5 0.0055 16.9 3.5 1.7 1 0 0 1 1 1 1 EGF-like domain Neuromodulin PF06614.9 017195.3_45723001_1 - 3.7e-57 193.1 61.0 3.7e-57 193.1 61.0 2.3 1 1 0 1 1 1 1 Neuromodulin Neuromodulin_N PF10580.7 017195.3_45723001_1 - 4.6e-18 64.5 6.1 2.1e-17 62.4 6.1 2.2 1 0 0 1 1 1 1 Gap junction protein N-terminal region IQ PF00612.25 017195.3_45723001_1 - 1.9e-06 27.0 0.4 5.3e-06 25.6 0.4 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif MRP-S32 PF10210.7 026065.4_32922001_2 - 1.5e-40 137.5 1.4 2.4e-40 136.9 1.4 1.3 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S32 MIS13 PF08202.9 001145316.1_26225001_2 - 1.5e-64 218.1 4.6 2.1e-64 217.6 4.6 1.1 1 0 0 1 1 1 1 Mis12-Mtw1 protein family FXMRP1_C_core PF12235.6 002024.5_26229001_2 - 3e-45 154.1 11.1 3e-45 154.1 11.1 3.5 2 1 1 3 3 3 1 Fragile X-related 1 protein core C terminal FXMR_C2 PF16098.3 002024.5_26229001_2 - 5.5e-39 132.4 5.9 5.5e-39 132.4 5.9 2.6 3 0 0 3 3 3 1 Fragile X-related mental retardation protein C-terminal region 2 KH_1 PF00013.27 002024.5_26229001_2 - 7.8e-15 54.3 2.0 2.1e-07 30.5 1.8 2.6 2 0 0 2 2 2 2 KH domain Agenet PF05641.10 002024.5_26229001_2 - 1.1e-11 44.9 1.4 6.4e-06 26.4 0.5 2.6 2 0 0 2 2 2 2 Agenet domain KH_2 PF07650.15 002024.5_26229001_2 - 0.022 14.4 0.9 1.9 8.2 0.0 2.4 2 0 0 2 2 2 0 KH domain Circo_capsid PF02443.13 002024.5_26229001_2 - 5.3 6.4 15.6 9.6 5.6 15.6 1.3 1 0 0 1 1 1 0 Circovirus capsid protein ATG_C PF09333.9 015104.2_26229001_2 - 1.3e-28 99.1 0.0 3.2e-28 97.8 0.0 1.7 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Chorein_N PF12624.5 015104.2_26229001_2 - 2.4e-18 66.2 0.0 4.5e-17 62.1 0.0 2.5 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 ATG2_CAD PF13329.4 015104.2_26229001_2 - 6e-06 26.0 0.1 1.2e-05 25.0 0.1 1.5 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif VPS13_C PF16909.3 015104.2_26229001_2 - 0.0024 17.5 0.0 0.0048 16.5 0.0 1.4 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal HAUS2 PF15003.4 001271129.1_45727001_1 - 0.17 11.4 0.2 0.26 10.8 0.2 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 2 Neuregulin PF02158.13 001271129.1_45727001_3 - 1.8e-187 623.5 21.2 1.8e-187 623.5 21.2 1.8 2 0 0 2 2 2 1 Neuregulin family I-set PF07679.14 001271129.1_45727001_3 - 1e-12 47.8 0.0 2.7e-12 46.5 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001271129.1_45727001_3 - 4.5e-11 43.1 0.5 1.9e-10 41.1 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001271129.1_45727001_3 - 4.9e-10 39.3 0.0 1.3e-09 37.9 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001271129.1_45727001_3 - 1.2e-07 31.9 0.3 6.1e-07 29.6 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.15 001271129.1_45727001_3 - 2e-05 24.6 0.1 0.00021 21.2 0.1 2.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain EGF PF00008.25 001271129.1_45727001_3 - 0.00013 22.1 3.5 0.00027 21.0 3.5 1.6 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.5 001271129.1_45727001_3 - 0.023 15.2 2.8 0.023 15.2 2.8 2.4 2 0 0 2 2 2 0 Human growth factor-like EGF Laminin_EGF PF00053.22 001271129.1_45727001_3 - 0.99 9.5 4.1 2.3 8.3 4.1 1.6 1 0 0 1 1 1 0 Laminin EGF domain EGF_2 PF07974.11 001271129.1_45727001_3 - 9.7 6.5 14.0 0.2 11.9 6.1 2.3 2 0 0 2 2 2 0 EGF-like domain Ras PF00071.20 057132.3_45722001_1 - 1.1e-58 197.3 0.0 1.3e-58 197.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 057132.3_45722001_1 - 1.5e-23 83.2 0.0 2e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 057132.3_45722001_1 - 3.5e-10 39.5 0.0 6.4e-10 38.6 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 057132.3_45722001_1 - 0.00023 20.6 0.0 0.00045 19.7 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.8 057132.3_45722001_1 - 0.033 13.5 0.0 0.055 12.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.10 057132.3_45722001_1 - 0.036 13.3 0.0 0.05 12.8 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region WD40 PF00400.30 001025664.1_45724001_2 - 4.2e-17 62.1 4.1 3.8e-07 30.6 0.1 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat SOCS_box PF07525.14 001025664.1_45724001_2 - 4.6e-10 39.5 0.3 4.6e-10 39.5 0.3 2.3 3 0 0 3 3 3 1 SOCS box Ge1_WD40 PF16529.3 001025664.1_45724001_2 - 1.5e-07 30.6 0.2 0.09 11.6 0.1 3.1 2 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.5 001025664.1_45724001_2 - 0.0037 17.4 0.0 9.5 6.5 0.0 3.2 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain TLV_coat PF00429.17 001348393.1_29625001_3 - 6e-29 101.0 0.0 6e-29 101.0 0.0 1.9 2 1 0 2 2 2 1 ENV polyprotein (coat polyprotein) LIAS_N PF16881.3 001348393.1_29625001_3 - 0.13 12.6 0.0 27 5.1 0.0 2.5 2 0 0 2 2 2 0 N-terminal domain of lipoyl synthase of Radical_SAM family SH3_9 PF14604.4 001109881.2_45726001_2 - 1.4e-20 72.7 1.5 8.1e-10 38.3 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.15 001109881.2_45726001_2 - 1.6e-16 59.6 0.1 2.8e-08 33.2 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.26 001109881.2_45726001_2 - 1.9e-16 59.2 0.4 8.7e-09 34.7 0.2 2.4 2 0 0 2 2 2 2 SH3 domain FCH PF00611.21 001109881.2_45726001_2 - 2.2e-16 59.8 0.1 2.2e-16 59.8 0.1 2.9 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain hSH3 PF14603.4 001109881.2_45726001_2 - 0.0013 19.1 0.0 0.0034 17.8 0.0 1.6 1 0 0 1 1 1 1 Helically-extended SH3 domain SH3_3 PF08239.9 001109881.2_45726001_2 - 0.029 14.5 0.1 0.059 13.5 0.1 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain Amelogenin PF02948.13 001271074.1_45722001_1 - 9.8e-65 218.3 54.2 2.1e-64 217.2 50.8 2.1 1 1 1 2 2 2 1 Amelogenin TFIIA PF03153.11 001271074.1_45722001_1 - 5.1 6.9 7.3 5.7 6.7 7.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2043 PF09740.7 153107.1_32929120_1 - 0.013 16.1 0.0 0.031 14.8 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2043) DUF2043 PF09740.7 153107.1_32929120_2 - 2.3e-18 66.7 1.4 4.2e-18 65.8 1.4 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2043) G_glu_transpept PF01019.19 153110.1_32929120_1 - 1e-22 80.5 0.0 1.3e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase G_glu_transpept PF01019.19 153110.1_32929120_2 - 3.3e-40 138.2 0.0 4.4e-40 137.8 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase G_glu_transpept PF01019.19 153110.1_32929120_3 - 3.6e-45 154.6 0.0 4.8e-45 154.2 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase GBP PF02263.17 135007.1_26226120_2 - 6.6e-124 412.2 0.0 8.5e-124 411.8 0.0 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.21 135007.1_26226120_2 - 0.0043 17.0 0.0 0.007 16.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RHD3 PF05879.10 135007.1_26226120_2 - 0.0077 14.3 0.0 0.011 13.7 0.0 1.2 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP_C PF02841.12 135007.1_26226120_3 - 2.6e-30 105.7 28.9 3.4e-30 105.3 28.9 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain HAUS6_N PF14661.4 135007.1_26226120_3 - 1.7 8.1 16.1 2.8 7.4 16.1 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus 7tm_2 PF00002.22 126014.1_45725120_2 - 2.7e-36 125.0 1.0 3.5e-36 124.6 1.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 126014.1_45725120_3 - 2.6e-16 59.5 1.1 4.8e-16 58.7 1.1 1.5 1 0 0 1 1 1 1 Hormone receptor domain 7tm_2 PF00002.22 126014.1_45725120_3 - 1e-15 57.6 2.4 1.4e-15 57.1 2.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) 7tm_2 PF00002.22 126013.1_45726120_2 - 4e-69 232.5 12.7 5.3e-69 232.1 12.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 126013.1_45726120_3 - 2.8e-16 59.4 1.1 5.4e-16 58.5 1.1 1.5 1 0 0 1 1 1 1 Hormone receptor domain 7tm_2 PF00002.22 126013.1_45726120_3 - 0.18 11.0 1.8 0.24 10.5 1.8 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) ASC PF00858.22 073548.1_32926120_1 - 1.9e-99 333.3 9.5 2.6e-99 332.8 9.5 1.2 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Focal_AT PF03623.11 148038.1_26229120_2 - 6.1e-56 187.9 2.3 8.4e-56 187.4 2.3 1.2 1 0 0 1 1 1 1 Focal adhesion targeting region Pkinase_Tyr PF07714.15 148038.1_26229120_3 - 1.6e-93 312.6 0.0 2.3e-93 312.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 148038.1_26229120_3 - 1.1e-45 156.0 0.0 1.6e-45 155.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain FERM_M PF00373.16 148038.1_26229120_3 - 1.2e-10 41.7 0.2 3.7e-10 40.1 0.2 1.8 2 0 0 2 2 2 1 FERM central domain Kinase-like PF14531.4 148038.1_26229120_3 - 0.0084 15.3 0.0 0.014 14.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like DUF4500 PF14937.4 153367.1_45722120_1 - 1.9e-20 72.5 0.0 2.7e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4500) GSAP-16 PF14959.4 153366.1_32927120_2 - 9.8e-19 67.1 0.0 1.6e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 gamma-Secretase-activating protein C-term JTB PF05439.10 153366.1_32927120_2 - 0.02 14.8 1.0 0.32 10.9 0.1 2.3 2 0 0 2 2 2 0 Jumping translocation breakpoint protein (JTB) Ribosomal_S4 PF00163.17 132729.1_45722120_3 - 1.1e-05 26.1 0.1 2e-05 25.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.23 132729.1_45722120_3 - 1.2e-05 24.7 1.3 2.9e-05 23.5 1.3 1.7 1 0 0 1 1 1 1 S4 domain MCM PF00493.21 001075290.2_06525001_1 - 5.1e-135 449.7 0.1 7.2e-135 449.2 0.1 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_OB PF17207.1 001075290.2_06525001_1 - 4.2e-40 136.4 0.4 7.9e-40 135.5 0.4 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.4 001075290.2_06525001_1 - 2e-18 66.8 2.1 2.1e-18 66.7 0.7 1.7 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.19 001075290.2_06525001_1 - 1.3e-06 27.9 0.0 0.00043 19.6 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.12 001075290.2_06525001_1 - 0.00091 19.1 0.0 0.0039 17.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.9 001075290.2_06525001_1 - 0.016 15.0 0.0 0.041 13.6 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.24 001075290.2_06525001_1 - 0.04 13.5 0.0 0.26 10.8 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AhpC-TSA_2 PF13911.4 001359939.1_49824001_2 - 1.2e-13 51.0 0.0 1.9e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.19 001359939.1_49824001_2 - 0.00011 22.0 0.0 0.00017 21.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.8 001359939.1_49824001_2 - 0.025 14.1 0.0 0.036 13.6 0.0 1.2 1 0 0 1 1 1 0 Redoxin Vps35 PF03635.15 022997.4_32927001_2 - 1.8e-298 992.0 12.4 2.1e-298 991.7 12.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 FerA PF08165.9 022997.4_32927001_2 - 0.07 12.9 1.3 0.15 11.9 0.2 2.1 2 0 0 2 2 2 0 FerA (NUC095) domain ADIP PF11559.6 022997.4_32927001_2 - 0.42 10.6 3.8 0.36 10.8 1.1 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding AhpC-TSA_2 PF13911.4 001359937.1_49823001_2 - 1.1e-13 51.2 0.0 1.6e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.19 001359937.1_49823001_2 - 9.7e-05 22.2 0.0 0.00014 21.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.8 001359937.1_49823001_2 - 0.022 14.3 0.0 0.031 13.8 0.0 1.1 1 0 0 1 1 1 0 Redoxin MRG PF05712.11 001359943.1_49826001_2 - 9e-64 214.3 0.3 1.4e-63 213.6 0.3 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.6 001359943.1_49826001_2 - 3.4e-05 23.5 0.3 0.00024 20.8 0.4 2.2 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain DNA_pol_phi PF04931.11 001359943.1_49826001_2 - 2.7 5.9 10.5 3.9 5.3 10.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Chromo PF00385.22 001359943.1_49826001_2 - 4.1 7.2 6.2 0.2 11.5 0.1 1.9 2 0 0 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain Nop25 PF09805.7 001359943.1_49826001_2 - 7.3 6.9 12.6 16 5.8 12.6 1.4 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) MRG PF05712.11 001359944.1_49825001_2 - 7.1e-64 214.6 0.3 1.1e-63 214.0 0.3 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.6 001359944.1_49825001_2 - 0.021 14.6 0.0 0.059 13.2 0.0 1.7 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain DNA_pol_phi PF04931.11 001359944.1_49825001_2 - 8.6 4.2 12.3 13 3.6 12.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi AhpC-TSA_2 PF13911.4 001359938.1_49823001_1 - 1.1e-13 51.2 0.0 1.7e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.19 001359938.1_49823001_1 - 9.9e-05 22.1 0.0 0.00014 21.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.8 001359938.1_49823001_1 - 0.022 14.3 0.0 0.032 13.8 0.0 1.1 1 0 0 1 1 1 0 Redoxin WD40 PF00400.30 153333.1_32926120_2 - 1.2e-57 190.3 15.5 1.4e-08 35.1 0.2 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 153333.1_32926120_2 - 7.8e-21 74.1 0.2 0.003 17.7 0.0 6.2 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 153333.1_32926120_2 - 1.6e-11 43.6 0.6 1.5 7.6 0.0 6.6 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.9 153333.1_32926120_2 - 3.8e-07 30.0 0.1 0.0035 17.1 0.1 2.8 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.10 153333.1_32926120_2 - 0.0008 17.4 0.0 0.023 12.6 0.0 2.1 2 0 0 2 2 2 1 IKI3 family Nup160 PF11715.6 153333.1_32926120_2 - 0.002 16.7 4.6 1.3 7.4 0.1 4.4 1 1 3 4 4 4 1 Nucleoporin Nup120/160 WD40_like PF17005.3 153333.1_32926120_2 - 0.0046 16.2 0.0 1.6 7.9 0.0 3.1 2 1 2 4 4 4 2 WD40-like domain Proteasome_A_N PF10584.7 153333.1_32926120_2 - 0.021 14.3 0.1 6.5 6.4 0.0 3.7 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Cytochrom_D1 PF02239.14 153333.1_32926120_2 - 0.074 11.4 0.1 16 3.7 0.0 2.6 1 1 0 3 3 3 0 Cytochrome D1 heme domain TRAPP PF04051.14 138582.1_32922120_3 - 7.8e-25 87.2 0.0 9.7e-25 86.9 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component zf-H2C2_2 PF13465.4 153375.1_32929120_1 - 3.3e-88 286.3 108.7 6.8e-09 35.6 0.9 16.3 17 0 0 17 17 16 13 Zinc-finger double domain zf-C2H2 PF00096.24 153375.1_32929120_1 - 6.9e-52 171.0 130.9 2.1e-05 24.6 0.4 16.3 18 0 0 18 18 16 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 153375.1_32929120_1 - 2.9e-37 124.0 102.2 0.00065 20.2 1.3 15.7 15 0 0 15 15 15 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 153375.1_32929120_1 - 1.8e-28 97.8 89.2 0.00058 19.6 0.2 14.6 14 0 0 14 14 14 11 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 153375.1_32929120_1 - 3.1e-14 52.7 63.1 0.0028 17.8 0.2 13.0 13 0 0 13 13 13 6 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 153375.1_32929120_1 - 6e-07 29.3 63.2 0.0095 15.9 1.4 10.1 7 4 3 11 11 11 6 Zinc ribbon domain zf-C2HE PF16278.3 153375.1_32929120_1 - 0.00064 20.0 70.1 0.97 9.8 7.9 11.3 3 2 5 8 8 8 4 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_15 PF17032.3 153375.1_32929120_1 - 0.014 16.0 55.1 0.36 11.5 0.7 7.7 3 2 2 7 7 7 0 zinc-ribbon family zf-C2H2_11 PF16622.3 153375.1_32929120_1 - 0.027 14.1 79.4 0.075 12.7 0.3 13.4 14 0 0 14 14 14 0 zinc-finger C2H2-type HypA PF01155.17 153375.1_32929120_1 - 0.039 13.8 0.4 0.039 13.8 0.4 7.4 2 1 3 5 5 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-met PF12874.5 153375.1_32929120_1 - 0.062 13.6 0.4 0.062 13.6 0.4 11.4 13 0 0 13 13 12 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.5 153375.1_32929120_1 - 0.14 12.4 61.9 1.2 9.4 1.9 9.4 1 1 5 8 8 8 0 C2H2 type zinc-finger (2 copies) DUF3268 PF11672.6 153375.1_32929120_1 - 0.18 12.0 31.8 0.16 12.2 0.6 5.9 5 1 1 6 6 6 0 zinc-finger-containing domain XPA_N PF01286.16 153375.1_32929120_1 - 2.4 8.1 58.4 12 5.9 0.5 13.5 14 0 0 14 14 14 0 XPA protein N-terminal KRAB PF01352.25 153375.1_32929120_3 - 5.1e-23 80.3 0.1 9.4e-23 79.5 0.1 1.5 1 0 0 1 1 1 1 KRAB box RUN PF02759.17 001347311.1_32928001_2 - 5.4e-25 87.8 0.0 8.9e-25 87.1 0.0 1.4 1 0 0 1 1 1 1 RUN domain zf-C3Hc3H PF13891.4 153345.1_32928120_2 - 6.6e-30 103.1 23.2 3.1e-16 59.3 5.0 2.6 2 0 0 2 2 2 2 Potential DNA-binding domain zf-TRM13_CCCH PF11722.6 153345.1_32928120_2 - 1.3 8.7 8.7 4.1 7.1 0.1 3.3 3 0 0 3 3 3 0 CCCH zinc finger in TRM13 protein LRR_9 PF14580.4 153377.1_06523120_3 - 3.2e-10 39.7 5.0 5.1e-10 39.0 5.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.5 153377.1_06523120_3 - 0.00017 21.7 10.2 2.3 8.6 0.0 3.4 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 153377.1_06523120_3 - 0.012 15.3 11.0 0.33 10.6 6.0 3.2 3 0 0 3 3 3 0 Leucine rich repeat LRR_1 PF00560.31 153377.1_06523120_3 - 2.1 9.0 6.0 30 5.5 0.8 4.1 3 0 0 3 3 3 0 Leucine Rich Repeat UQ_con PF00179.24 038137.1_06522120_3 - 1.4e-34 118.6 0.1 2.2e-34 117.9 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Linker_histone PF00538.17 015787.4_32922001_2 - 1.6e-23 82.7 0.6 4.2e-23 81.4 0.6 1.7 1 0 0 1 1 1 1 linker histone H1 and H5 family PKD PF00801.18 024874.4_26229001_1 - 2.3e-11 43.2 8.0 0.0031 17.2 0.3 5.7 5 0 0 5 5 5 3 PKD domain Y_Y_Y PF07495.11 024874.4_26229001_1 - 8.7e-11 41.5 2.8 0.016 15.0 0.0 5.2 5 0 0 5 5 5 3 Y_Y_Y domain DUF4625 PF15418.4 024874.4_26229001_1 - 2.4e-07 30.9 0.8 0.25 11.4 0.0 4.4 4 0 0 4 4 4 2 Domain of unknown function (DUF4625) Wzt_C PF14524.4 024874.4_26229001_1 - 0.0017 18.2 0.2 15 5.5 0.0 4.2 5 0 0 5 5 5 1 Wzt C-terminal domain DUF5013 PF16405.3 024874.4_26229001_1 - 0.004 17.3 3.9 0.42 10.8 0.1 4.1 4 1 0 5 5 5 1 Domain of unknown function (DUF5013) DUF4998 PF16389.3 024874.4_26229001_1 - 0.028 13.9 2.5 4.3 6.7 0.0 3.6 5 0 0 5 5 5 0 Domain of unknown function He_PIG PF05345.10 024874.4_26229001_1 - 0.12 12.5 15.1 6.7 6.8 0.0 5.5 6 0 0 6 6 6 0 Putative Ig domain Big_3_2 PF12245.6 024874.4_26229001_1 - 0.16 11.7 0.1 8.1 6.2 0.0 3.1 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) CHU_C PF13585.4 024874.4_26229001_1 - 0.2 11.6 0.4 50 3.9 0.0 3.8 4 0 0 4 4 4 0 C-terminal domain of CHU protein family DUF5011 PF16403.3 024874.4_26229001_1 - 0.43 10.6 9.1 41 4.2 0.2 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF5011) Peptidase_M14 PF00246.22 030231.3_32924001_1 - 1.3e-25 90.7 0.0 5.5e-25 88.6 0.0 1.9 1 1 0 1 1 1 1 Zinc carboxypeptidase MFS_1 PF07690.14 001081791.2_21027001_2 - 4e-41 141.0 35.1 3.6e-34 118.1 23.3 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3185 PF11381.6 001081791.2_21027001_2 - 0.043 13.7 0.1 0.63 10.0 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) CbtA PF09490.8 001081791.2_21027001_2 - 1.4 8.5 5.1 0.45 10.1 0.6 2.3 2 1 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) IP_trans PF02121.16 153311.1_32929120_2 - 8.8e-75 251.3 2.7 1.3e-74 250.8 2.7 1.1 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein IP_trans PF02121.16 153311.1_32929120_3 - 2.5e-27 95.9 0.0 3.7e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein zf-NF-X1 PF01422.15 153351.1_32928120_2 - 0.0064 16.4 12.4 0.0064 16.4 12.4 10.0 11 0 0 11 11 11 5 NF-X1 type zinc finger zf-NF-X1 PF01422.15 153351.1_32928120_3 - 6.2e-11 42.0 87.8 1.1e-05 25.2 13.4 8.4 9 0 0 9 9 9 4 NF-X1 type zinc finger Apis_Csd PF11671.6 153357.1_32925120_1 - 7.4 6.4 10.7 13 5.7 10.7 1.3 1 0 0 1 1 1 0 Complementary sex determiner protein SMAP PF15477.4 153357.1_32925120_2 - 9.8e-17 61.5 1.6 9.8e-17 61.5 1.6 3.6 3 1 0 3 3 3 1 Small acidic protein family SMAP PF15477.4 153359.1_32925120_1 - 9.8e-17 61.5 1.6 9.8e-17 61.5 1.6 3.6 2 1 0 2 2 2 1 Small acidic protein family Pap_E4 PF02711.12 153359.1_32925120_1 - 0.36 11.8 0.1 0.36 11.8 0.1 5.5 2 1 1 3 3 3 0 E4 protein BTB_2 PF02214.20 153196.1_32928120_1 - 4.7e-22 78.0 0.0 7.9e-22 77.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain WD40 PF00400.30 153196.1_32928120_3 - 0.23 12.3 4.7 32 5.5 0.0 4.2 4 0 0 4 4 4 0 WD domain, G-beta repeat Ephrin_rec_like PF07699.11 153370.1_32929120_3 - 1.6e-08 34.1 82.4 0.00057 19.5 5.8 8.4 5 3 3 8 8 8 7 Putative ephrin-receptor like NCD3G PF07562.12 153370.1_32929120_3 - 1.1e-05 25.1 55.9 0.014 15.2 8.2 7.0 5 1 0 5 5 5 4 Nine Cysteines Domain of family 3 GPCR Herpes_UL52 PF03121.13 151680.1_32928120_2 - 7.6e-16 57.7 0.4 1.5e-15 56.7 0.4 1.6 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase PAS_3 PF08447.10 001315687.1_49828001_2 - 9.9e-24 83.3 0.0 7.3e-18 64.5 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 001315687.1_49828001_2 - 1.3e-22 79.8 0.1 1.2e-14 54.1 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 001315687.1_49828001_2 - 6.4e-22 77.7 0.4 9.8e-20 70.6 0.2 2.6 2 0 0 2 2 2 1 PAS domain HLH PF00010.24 001315687.1_49828001_2 - 8.1e-15 54.4 1.1 1.6e-14 53.4 1.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 001315687.1_49828001_2 - 1.2e-08 35.0 0.0 7.4e-06 26.0 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 001315687.1_49828001_2 - 0.0039 17.3 0.0 1.6 8.9 0.0 2.5 2 0 0 2 2 2 2 PAS fold PRAS PF15798.3 001315687.1_49828001_2 - 0.061 13.7 0.2 0.18 12.2 0.2 1.8 1 0 0 1 1 1 0 Proline-rich AKT1 substrate 1 Ras PF00071.20 001350009.1_26225001_2 - 2.5e-36 124.6 0.1 3.8e-36 124.0 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001350009.1_26225001_2 - 2.4e-33 114.8 0.0 3.8e-33 114.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001350009.1_26225001_2 - 9.3e-10 38.1 0.0 1.5e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001350009.1_26225001_2 - 9.7e-06 25.0 0.0 1.4e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001350009.1_26225001_2 - 0.0002 20.8 0.1 0.00089 18.7 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001350009.1_26225001_2 - 0.00025 21.0 0.0 0.00042 20.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.8 001350009.1_26225001_2 - 0.044 13.1 0.0 0.068 12.5 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit NO_synthase PF02898.13 000625.4_26229001_1 - 1.2e-185 616.7 0.0 1.6e-185 616.3 0.0 1.1 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.18 000625.4_26229001_1 - 1.6e-83 279.5 0.0 2.4e-83 278.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 000625.4_26229001_1 - 8.8e-42 142.6 0.0 1.7e-41 141.6 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.19 000625.4_26229001_1 - 1.8e-22 79.9 0.0 3.5e-22 79.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.10 000625.4_26229001_1 - 0.15 12.0 0.0 0.38 10.7 0.0 1.6 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Acyltransferase PF01553.19 001025748.1_45724001_2 - 3.9e-42 142.9 0.0 5.3e-42 142.5 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Connexin PF00029.17 001004099.2_45725001_2 - 2.4e-85 285.8 9.7 3.3e-85 285.3 9.7 1.2 1 0 0 1 1 1 1 Connexin Kisspeptin PF15152.4 181692.1_45721001_1 - 4.7e-36 123.3 0.6 6.4e-36 122.8 0.6 1.2 1 0 0 1 1 1 1 Kisspeptin Myosin_head PF00063.19 001127180.1_26229001_3 - 3.3e-240 798.8 0.4 4.3e-240 798.4 0.4 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.15 001127180.1_26229001_3 - 2.1e-60 201.7 0.0 4.1e-30 104.3 0.0 3.4 2 0 0 2 2 2 2 MyTH4 domain FERM_M PF00373.16 001127180.1_26229001_3 - 1.1e-23 83.7 6.2 5.1e-17 62.2 0.0 3.9 4 0 0 4 4 4 2 FERM central domain IQ PF00612.25 001127180.1_26229001_3 - 1.2e-14 52.5 17.8 1.5e-05 24.2 0.1 4.9 4 0 0 4 4 4 4 IQ calmodulin-binding motif FERM_N PF09379.8 001127180.1_26229001_3 - 1.6e-09 37.5 0.3 0.0022 17.8 0.1 2.7 2 0 0 2 2 2 2 FERM N-terminal domain SH3_9 PF14604.4 001127180.1_26229001_3 - 0.0029 17.3 0.1 0.021 14.5 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 001127180.1_26229001_3 - 0.01 15.3 1.2 0.048 13.1 0.0 2.7 3 0 0 3 3 3 0 SH3 domain AAA_16 PF13191.4 001127180.1_26229001_3 - 0.024 14.9 2.0 0.14 12.4 0.0 2.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.4 001127180.1_26229001_3 - 0.027 14.6 4.1 0.14 12.3 0.0 3.9 3 1 1 4 4 4 0 AAA domain RA PF00788.21 001127180.1_26229001_3 - 0.099 13.2 0.0 14 6.3 0.0 2.7 2 0 0 2 2 2 0 Ras association (RalGDS/AF-6) domain SH3_2 PF07653.15 001127180.1_26229001_3 - 0.13 11.9 0.0 0.42 10.2 0.0 2.0 1 0 0 1 1 1 0 Variant SH3 domain ABC_tran PF00005.25 001127180.1_26229001_3 - 0.33 11.3 2.0 0.33 11.3 0.0 2.0 2 0 0 2 2 2 0 ABC transporter Med17 PF10156.7 001127180.1_26229001_3 - 2 6.9 10.6 3.1 6.3 10.6 1.2 1 0 0 1 1 1 0 Subunit 17 of Mediator complex 7tm_1 PF00001.19 001030015.2_26225001_3 - 3.6e-51 173.8 16.7 5.4e-51 173.3 16.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.6 001030015.2_26225001_3 - 1.3 8.6 11.5 2.5 7.7 11.5 1.4 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 7tm_4 PF13853.4 001030015.2_26225001_3 - 3.7 7.1 11.5 0.38 10.3 5.4 2.2 2 1 0 2 2 2 0 Olfactory receptor Pkinase PF00069.23 153500.1_26229001_2 - 2.5e-61 207.2 0.0 7.2e-61 205.7 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 153500.1_26229001_2 - 4e-32 111.4 0.0 1.1e-30 106.7 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.4 153500.1_26229001_2 - 4.7e-07 29.3 0.0 8.8e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like SRP40_C PF05022.10 153500.1_26229001_2 - 0.12 13.1 0.8 0.33 11.7 0.8 1.7 1 0 0 1 1 1 0 SRP40, C-terminal domain HDAC4_Gln PF12203.6 001321900.1_26229001_2 - 1.5e-31 108.3 43.7 1.5e-31 108.3 43.7 3.6 4 0 0 4 4 4 1 Glutamine rich N terminal domain of histone deacetylase 4 Lectin_C PF00059.19 207345.3_26224001_2 - 4.2e-18 65.9 8.1 5.2e-16 59.2 1.0 3.1 2 1 1 3 3 3 2 Lectin C-type domain UL45 PF05473.10 207345.3_26224001_2 - 0.00013 21.6 7.3 0.03 13.8 0.0 3.3 3 1 0 3 3 3 2 UL45 protein, carbohydrate-binding C-type lectin-like DUF2162 PF09930.7 207345.3_26224001_2 - 0.008 15.5 3.5 0.014 14.7 3.5 1.3 1 0 0 1 1 1 1 Predicted transporter (DUF2162) SET PF00856.26 001321082.1_26229001_3 - 1.5e-17 64.4 0.9 4.4e-17 62.9 0.2 2.2 2 0 0 2 2 2 1 SET domain EZH2_WD-Binding PF11616.6 001321082.1_26229001_3 - 5.7e-17 61.4 0.7 1.2e-16 60.4 0.7 1.5 1 0 0 1 1 1 1 WD repeat binding protein EZH2 WSK PF03832.11 057103.2_45729001_1 - 1.1e-31 108.1 31.3 1.3e-12 47.0 4.4 5.6 4 0 0 4 4 4 3 WSK motif RII_binding_1 PF10522.7 057103.2_45729001_1 - 1.3e-05 24.7 0.3 5.2e-05 22.9 0.3 2.2 1 0 0 1 1 1 1 RII binding domain Pkinase PF00069.23 001324078.1_26223001_2 - 2.6e-59 200.6 0.0 1.5e-51 175.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 001324078.1_26223001_2 - 7.2e-21 74.5 0.0 6.6e-18 64.8 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.4 001324078.1_26223001_2 - 4.8e-05 22.7 0.2 0.0033 16.6 0.0 2.1 2 0 0 2 2 2 2 Kinase-like Seadorna_VP7 PF07387.9 001324078.1_26223001_2 - 0.0018 17.2 0.0 0.0029 16.6 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.21 001324078.1_26223001_2 - 0.013 15.3 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3583 PF12126.6 033250.2_26226001_3 - 9.5e-147 488.6 22.5 1.5e-99 333.5 8.0 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3583) zf-B_box PF00643.22 033250.2_26226001_3 - 6.3e-08 32.5 4.3 6.3e-08 32.5 4.3 4.1 4 1 0 4 4 4 2 B-box zinc finger zf-C3HC4_3 PF13920.4 033250.2_26226001_3 - 0.00015 21.4 10.9 0.00015 21.4 10.9 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 033250.2_26226001_3 - 0.0036 17.0 13.0 0.0036 17.0 13.0 3.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 033250.2_26226001_3 - 0.0083 15.9 12.3 0.0083 15.9 12.3 3.6 3 0 0 3 3 3 2 zinc-RING finger domain Cep57_CLD_2 PF14197.4 033250.2_26226001_3 - 0.044 13.7 2.0 0.12 12.4 2.0 1.8 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 OmpH PF03938.12 033250.2_26226001_3 - 0.053 13.4 4.0 0.094 12.6 4.0 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Apolipoprotein PF01442.16 033250.2_26226001_3 - 0.25 11.1 8.7 0.57 9.9 8.7 1.6 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Sigma70_ner PF04546.11 033250.2_26226001_3 - 0.3 10.8 2.4 0.57 9.9 2.4 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region AdoHcyase PF05221.15 001322085.1_26227001_3 - 5.2e-129 429.5 0.0 4.3e-68 229.5 0.1 2.1 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.19 001322085.1_26227001_3 - 1.1e-85 285.5 3.3 1.7e-85 284.9 3.3 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.17 001322085.1_26227001_3 - 3.2e-08 33.0 0.1 6.6e-08 32.0 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.10 001322085.1_26227001_3 - 7.8e-05 22.2 0.1 0.00015 21.3 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.16 001322085.1_26227001_3 - 0.0059 16.7 0.1 0.011 15.9 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain 3HCDH_N PF02737.16 001322085.1_26227001_3 - 0.095 12.4 0.4 0.25 11.1 0.4 1.7 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ecTbetaR2 PF08917.8 001177748.1_37924001_1 - 3.4e-43 145.9 17.0 7.9e-43 144.8 17.0 1.7 1 0 0 1 1 1 1 Transforming growth factor beta receptor 2 ectodomain Pkinase_Tyr PF07714.15 001177748.1_37924001_1 - 7.3e-36 123.6 0.1 1.6e-35 122.6 0.1 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001177748.1_37924001_1 - 4.5e-35 121.2 0.0 7.2e-35 120.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.21 001177748.1_37924001_1 - 0.028 14.2 0.1 0.052 13.3 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Trypsin PF00089.24 001001259.1_49828001_1 - 1.5e-69 234.1 0.0 2.7e-69 233.2 0.0 1.5 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 001001259.1_49828001_1 - 4.2e-48 162.1 0.0 1.8e-27 95.7 0.0 2.8 2 0 0 2 2 2 2 CUB domain MAM PF00629.21 001001259.1_49828001_1 - 2.3e-38 131.5 0.0 4.5e-38 130.5 0.0 1.5 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu SEA PF01390.18 001001259.1_49828001_1 - 2.3e-19 69.5 0.4 5.6e-19 68.2 0.4 1.7 1 0 0 1 1 1 1 SEA domain Ldl_recept_a PF00057.16 001001259.1_49828001_1 - 4.1e-12 46.0 30.1 9.1e-09 35.3 9.8 2.9 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A DUF1986 PF09342.9 001001259.1_49828001_1 - 1.6e-10 41.2 0.0 6.3e-10 39.3 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1986) SRCR PF00530.16 001001259.1_49828001_1 - 5.9e-10 39.4 1.6 1.5e-09 38.1 0.2 2.4 3 0 0 3 3 3 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.4 001001259.1_49828001_1 - 2.7e-06 27.7 0.4 8.1e-06 26.1 0.4 1.8 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain CUB_2 PF02408.18 001001259.1_49828001_1 - 0.011 15.4 0.6 1.2 8.8 0.1 2.8 2 0 0 2 2 2 0 CUB-like domain PRKCSH-like PF12999.5 001001259.1_49828001_1 - 0.14 11.8 8.1 3.5 7.2 0.3 2.5 2 0 0 2 2 2 0 Glucosidase II beta subunit-like Trypsin PF00089.24 001266588.1_29624001_1 - 3.5e-75 252.5 0.1 4.5e-75 252.1 0.1 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 001266588.1_29624001_1 - 2e-09 37.7 0.1 4.4e-09 36.6 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 001266588.1_29624001_1 - 0.0016 19.2 0.0 0.003 18.3 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.24 001194861.2_29623001_1 - 1.5e-26 93.5 0.0 2.5e-26 92.7 0.0 1.3 1 1 0 1 1 1 1 Trypsin DUF1986 PF09342.9 001194861.2_29623001_1 - 0.0063 16.8 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin PF00089.24 001285330.1_29525001_1 - 2.9e-68 229.8 0.1 4.3e-68 229.3 0.1 1.3 1 0 0 1 1 1 1 Trypsin SRCR_2 PF15494.4 001285330.1_29525001_1 - 8.1e-38 128.8 0.2 1.7e-37 127.7 0.2 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Trypsin_2 PF13365.4 001285330.1_29525001_1 - 9.5e-07 29.7 0.1 2.1e-06 28.5 0.1 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001285330.1_29525001_1 - 2.9e-06 27.5 0.1 5.2e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) SRCR PF00530.16 001285330.1_29525001_1 - 0.00087 19.6 0.1 0.003 17.9 0.1 1.9 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Diphthamide_syn PF01866.15 144474.1_26226120_1 - 8.2e-57 192.8 0.0 1.1e-56 192.4 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Hep_core_N PF08290.9 144474.1_26226120_1 - 0.043 13.6 1.0 0.28 11.1 1.0 2.5 1 0 0 1 1 1 0 Hepatitis core protein, putative zinc finger Diphthamide_syn PF01866.15 144474.1_26226120_2 - 2.1e-53 181.6 0.1 2.7e-53 181.2 0.1 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein FSH1 PF03959.11 144474.1_26226120_3 - 5.4e-38 130.7 0.0 7.3e-38 130.2 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.14 144474.1_26226120_3 - 3.8e-05 23.5 0.0 5.7e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Pkinase PF00069.23 132730.1_26223120_2 - 7.6e-55 186.0 0.0 9.4e-55 185.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 132730.1_26223120_2 - 8.8e-30 103.7 0.0 1.2e-29 103.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 132730.1_26223120_2 - 0.00051 19.3 0.0 0.00061 19.1 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 132730.1_26223120_2 - 0.15 11.3 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Arf PF00025.19 051955.2_26226120_1 - 3.1e-27 95.0 0.1 4.8e-27 94.4 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 051955.2_26226120_1 - 8.1e-11 42.1 0.1 1.2e-10 41.5 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 051955.2_26226120_1 - 2e-06 27.4 0.1 2.8e-06 26.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.10 051955.2_26226120_1 - 1.8e-05 24.1 0.0 2.4e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 051955.2_26226120_1 - 1.9e-05 24.6 0.0 2.8e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.8 051955.2_26226120_1 - 0.00027 20.3 0.0 0.00038 19.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 051955.2_26226120_1 - 0.00075 18.6 0.2 0.49 9.3 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Arf PF00025.19 051955.2_26226120_2 - 9e-09 34.9 0.0 1.3e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Rad4 PF03835.13 148951.1_26227120_2 - 8.6e-23 80.5 0.2 1.9e-22 79.4 0.2 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain SOG2 PF10428.7 148951.1_26227120_2 - 0.0058 15.8 7.3 0.0078 15.4 7.3 1.1 1 0 0 1 1 1 1 RAM signalling pathway protein BHD_3 PF10405.7 148951.1_26227120_3 - 3.1e-25 88.2 0.0 6.4e-25 87.2 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_2 PF10404.7 148951.1_26227120_3 - 1.6e-14 54.5 0.3 1.6e-14 54.5 0.3 3.6 2 1 0 2 2 2 1 Rad4 beta-hairpin domain 2 DUF4820 PF16091.3 148951.1_26227120_3 - 0.5 9.6 4.0 1 8.5 4.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Fibrinogen_C PF00147.16 024118.1_45722120_1 - 1.7e-82 276.4 4.4 2e-82 276.2 4.4 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Bax1-I PF01027.18 001244383.2_49826001_2 - 1.8e-39 135.6 14.5 4e-39 134.5 14.5 1.6 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 EF-hand_7 PF13499.4 001172988.2_09922001_1 - 7.7e-13 48.6 1.1 1.2e-12 48.0 1.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001172988.2_09922001_1 - 1.7e-12 45.8 4.3 2.6e-05 23.3 1.3 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 001172988.2_09922001_1 - 2e-11 43.4 1.7 2.2e-05 24.0 0.2 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001172988.2_09922001_1 - 1.9e-10 39.7 2.5 4e-05 23.1 0.3 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.4 001172988.2_09922001_1 - 4.1e-10 38.6 5.3 0.00019 20.7 0.2 2.4 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.7 001172988.2_09922001_1 - 0.029 14.6 0.2 0.045 14.0 0.2 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Toprim_2 PF13155.4 001172988.2_09922001_1 - 0.086 13.2 0.3 3 8.3 0.1 2.3 1 1 1 2 2 2 0 Toprim-like EF-hand_10 PF14788.4 001172988.2_09922001_1 - 0.13 12.0 1.7 0.2 11.4 0.4 2.0 2 0 0 2 2 2 0 EF hand Pkinase PF00069.23 001359991.1_32926001_3 - 3e-49 167.6 0.0 4.1e-49 167.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001359991.1_32926001_3 - 1.8e-15 56.8 0.0 3e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001359991.1_32926001_3 - 0.014 15.1 0.1 0.023 14.5 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Bax1-I PF01027.18 001244382.2_49826001_1 - 2e-39 135.5 14.5 4.2e-39 134.4 14.5 1.6 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 AhpC-TSA_2 PF13911.4 001359936.1_49824001_2 - 1.4e-13 50.9 0.0 2.2e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.19 001359936.1_49824001_2 - 0.00013 21.8 0.0 0.00019 21.2 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.8 001359936.1_49824001_2 - 0.029 13.9 0.0 0.041 13.4 0.0 1.2 1 0 0 1 1 1 0 Redoxin EF-hand_1 PF00036.30 001173034.2_09925001_3 - 2.8e-40 132.7 9.6 3.1e-09 35.6 0.4 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 001173034.2_09925001_3 - 1.1e-34 118.6 2.7 6.4e-18 64.9 0.7 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 001173034.2_09925001_3 - 4.4e-32 109.5 9.5 4.8e-15 54.9 0.4 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.4 001173034.2_09925001_3 - 5.2e-28 94.4 5.7 8.2e-09 34.6 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.4 001173034.2_09925001_3 - 9.5e-25 84.8 6.9 6.3e-06 25.3 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.4 001173034.2_09925001_3 - 9.5e-14 51.3 0.2 2.7e-08 33.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 001173034.2_09925001_3 - 3e-08 33.4 0.2 0.00064 19.5 0.1 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 001173034.2_09925001_3 - 3.9e-06 27.0 0.0 0.049 13.8 0.0 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.9 001173034.2_09925001_3 - 0.00023 21.9 0.0 0.012 16.4 0.0 2.2 1 1 1 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.8 001173034.2_09925001_3 - 0.00055 19.8 0.6 0.001 19.0 0.1 1.6 2 0 0 2 2 2 1 Ca2+ insensitive EF hand UPF0154 PF03672.11 001173034.2_09925001_3 - 0.0015 18.4 0.0 0.3 11.0 0.0 2.7 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0154) DUF1636 PF07845.9 001173034.2_09925001_3 - 0.016 15.5 0.0 0.046 14.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1636) DUF1103 PF06513.9 001173034.2_09925001_3 - 0.017 14.6 1.5 0.024 14.1 1.5 1.1 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) DUF4497 PF14924.4 001173034.2_09925001_3 - 0.051 13.9 0.0 9.3 6.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4497) DUF3349 PF11829.6 001173034.2_09925001_3 - 0.1 13.2 0.3 9.3 7.0 0.0 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) Caleosin PF05042.11 001173034.2_09925001_3 - 0.15 11.8 0.1 3.8 7.3 0.0 2.6 1 1 2 3 3 3 0 Caleosin related protein RNA_pol_Rpb4 PF03874.14 001173034.2_09925001_3 - 0.21 11.8 0.5 11 6.2 0.1 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb4 Lipocalin PF00061.21 001173092.1_09922001_3 - 1.2e-17 64.3 2.5 1.5e-17 64.0 2.5 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001173092.1_09922001_3 - 0.0008 19.2 0.7 0.001 18.8 0.7 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family CAP PF00188.24 001172934.1_09923001_2 - 2e-23 83.4 3.4 2.8e-23 83.0 3.4 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Crisp PF08562.8 001172934.1_09923001_2 - 1.4e-19 70.3 19.6 3.5e-19 69.0 19.6 1.7 1 0 0 1 1 1 1 Crisp Enolase_C PF00113.20 001173073.1_09924001_1 - 5.3e-158 524.8 0.0 6.8e-158 524.4 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.14 001173073.1_09924001_1 - 3.6e-61 205.0 0.1 7.5e-61 203.9 0.1 1.6 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.4 001173073.1_09924001_1 - 1.8e-08 34.2 0.0 2.7e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.9 001173073.1_09924001_1 - 0.00066 18.8 0.2 0.0015 17.6 0.2 1.6 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus Trypsin PF00089.24 001246627.1_39724001_1 - 1.6e-26 93.4 0.0 2.4e-26 92.8 0.0 1.2 1 0 0 1 1 1 1 Trypsin Trypsin PF00089.24 001257148.1_21023001_1 - 1.9e-10 40.8 0.0 7.8e-09 35.5 0.0 2.4 2 0 0 2 2 2 1 Trypsin Trypsin_2 PF13365.4 001257148.1_21023001_1 - 5.2e-06 27.3 0.0 1.3e-05 26.0 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S46 PF10459.7 001257148.1_21023001_1 - 0.079 11.5 0.0 0.12 10.8 0.0 1.2 1 0 0 1 1 1 0 Peptidase S46 Trypsin PF00089.24 001080306.1_06524001_1 - 1.3e-10 41.3 0.1 5.5e-10 39.3 0.1 2.0 1 1 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001080306.1_06524001_1 - 2.5e-08 34.8 0.0 3.9e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain FB_lectin PF07367.9 001080306.1_06524001_1 - 0.29 10.9 1.3 2.6 7.8 0.0 2.6 3 0 0 3 3 3 0 Fungal fruit body lectin Histone_H2A_C PF16211.3 001172972.1_09922001_2 - 1.3 8.7 4.2 2.2 8.0 4.2 1.3 1 0 0 1 1 1 0 C-terminus of histone H2A ISK_Channel PF02060.13 001172972.1_09922001_3 - 3.8e-61 204.0 0.0 5.2e-61 203.6 0.0 1.2 1 0 0 1 1 1 1 Slow voltage-gated potassium channel Ferritin PF00210.22 001172858.1_09922001_3 - 4.1e-28 98.0 0.9 5e-28 97.7 0.9 1.1 1 0 0 1 1 1 1 Ferritin-like domain 7tm_1 PF00001.19 001311080.1_09924001_2 - 1.7e-49 168.4 10.9 2.2e-49 168.0 10.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001311080.1_09924001_2 - 3.3e-10 39.6 6.8 8.4e-10 38.3 6.8 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.7 001311080.1_09924001_2 - 4.8e-07 29.3 9.9 6.6e-07 28.8 9.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001311080.1_09924001_2 - 6.5e-06 25.6 7.9 1e-05 25.0 7.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001311080.1_09924001_2 - 0.00043 20.0 8.7 0.0055 16.3 4.0 2.4 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001311080.1_09924001_2 - 0.00074 18.8 4.1 0.00074 18.8 4.1 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx MRG PF05712.11 001244094.2_49825001_2 - 7.7e-64 214.5 0.3 1.2e-63 213.8 0.3 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.6 001244094.2_49825001_2 - 8.1e-05 22.3 0.4 0.00021 21.0 0.4 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.22 001244094.2_49825001_2 - 0.1 12.3 0.2 0.1 12.3 0.2 1.8 2 0 0 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain DNA_pol_phi PF04931.11 001244094.2_49825001_2 - 2.5 6.0 10.5 3.6 5.5 10.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop25 PF09805.7 001244094.2_49825001_2 - 6.6 7.1 12.6 14 6.0 12.6 1.4 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) AhpC-TSA_2 PF13911.4 001244375.2_49824001_2 - 1.3e-13 50.9 0.0 2e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.19 001244375.2_49824001_2 - 0.00011 21.9 0.0 0.00017 21.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.8 001244375.2_49824001_2 - 0.026 14.1 0.0 0.037 13.6 0.0 1.2 1 0 0 1 1 1 0 Redoxin 7tm_1 PF00001.19 001172752.1_09923001_1 - 1.2e-32 113.1 22.3 1.7e-32 112.6 22.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2678 PF10856.6 001172752.1_09923001_1 - 2.3 8.0 11.1 0.17 11.7 3.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2678) MRG PF05712.11 001359942.1_49825001_3 - 8.5e-64 214.4 0.3 1.3e-63 213.7 0.3 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.6 001359942.1_49825001_3 - 9.8e-05 22.1 0.5 0.00026 20.7 0.5 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain DNA_pol_phi PF04931.11 001359942.1_49825001_3 - 2.6 5.9 10.5 3.8 5.4 10.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Chromo PF00385.22 001359942.1_49825001_3 - 4 7.3 6.2 0.19 11.5 0.1 1.9 2 0 0 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain Nop25 PF09805.7 001359942.1_49825001_3 - 7 7.0 12.6 15 5.9 12.6 1.4 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) SRCR PF00530.16 001071807.2_39729001_3 - 6.7e-118 385.8 31.3 9.1e-32 109.4 4.1 4.5 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Trypsin PF00089.24 001071807.2_39729001_3 - 9.5e-65 218.4 0.0 1.4e-64 217.8 0.0 1.3 1 0 0 1 1 1 1 Trypsin SRCR_2 PF15494.4 001071807.2_39729001_3 - 9.5e-24 83.7 13.6 1.2e-06 28.8 0.9 4.5 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Kringle PF00051.16 001071807.2_39729001_3 - 2.9e-09 37.0 0.7 9.4e-09 35.3 0.7 1.8 1 0 0 1 1 1 1 Kringle domain DUF1986 PF09342.9 001071807.2_39729001_3 - 0.029 14.6 0.0 0.052 13.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Rdx PF10262.7 001257992.1_09922001_2 - 1.1e-10 41.4 0.0 1.7e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Rdx family Prothymosin PF03247.12 001244635.2_39722001_2 - 6.3e-36 123.1 51.0 7.9e-36 122.8 51.0 1.1 1 0 0 1 1 1 1 Prothymosin/parathymosin family CDC45 PF02724.12 001244635.2_39722001_2 - 1.8 6.6 21.2 2.1 6.4 21.2 1.1 1 0 0 1 1 1 0 CDC45-like protein SAPS PF04499.13 001244635.2_39722001_2 - 4.7 5.7 10.4 5.5 5.5 10.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DEAD PF00270.27 014829.3_26229001_2 - 5e-50 169.6 0.1 1.5e-49 168.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 014829.3_26229001_2 - 1.1e-26 93.2 0.0 1.4e-25 89.7 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Integrin_alpha2 PF08441.10 001114177.2_21029001_3 - 1.7e-42 145.7 0.0 2.7e-42 145.1 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.26 001114177.2_21029001_3 - 5.2e-39 134.2 0.6 7.7e-39 133.6 0.6 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.21 001114177.2_21029001_3 - 6.8e-19 67.5 6.9 7.9e-08 32.2 0.6 3.7 3 0 0 3 3 3 3 FG-GAP repeat VWA_2 PF13519.4 001114177.2_21029001_3 - 7.2e-14 52.2 0.2 1.4e-13 51.3 0.2 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VCBS PF13517.4 001114177.2_21029001_3 - 1.4e-05 25.5 0.1 0.071 13.6 0.0 2.9 2 1 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella VWA_CoxE PF05762.12 001114177.2_21029001_3 - 5.1e-05 22.6 0.0 8.5e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Integrin_alpha PF00357.18 001114177.2_21029001_3 - 0.0001 21.9 1.5 0.00025 20.7 1.5 1.7 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region FG-GAP_2 PF14312.4 001114177.2_21029001_3 - 0.012 15.7 3.3 3.5 7.8 0.0 4.1 5 0 0 5 5 5 0 FG-GAP repeat TNF PF00229.16 001173025.1_09923001_3 - 1.9e-38 131.2 0.0 2.8e-38 130.6 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family zf-RING_2 PF13639.4 001251899.1_39728001_3 - 4e-08 33.3 4.4 4e-08 33.3 4.4 3.8 4 0 0 4 4 4 1 Ring finger domain zf-RING_11 PF17123.3 001251899.1_39728001_3 - 0.00015 21.3 4.5 0.00015 21.3 4.5 3.8 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4_2 PF13923.4 001251899.1_39728001_3 - 0.0017 18.0 3.6 0.0017 18.0 3.6 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001251899.1_39728001_3 - 0.015 15.4 1.6 0.015 15.4 1.6 3.0 3 0 0 3 3 3 0 RING-H2 zinc finger domain RNF220 PF15926.3 001251899.1_39728001_3 - 0.23 10.9 0.1 0.42 10.0 0.1 1.3 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 Hormone_1 PF00103.18 001195110.2_09922001_2 - 2.6e-42 144.9 2.6 3.1e-42 144.6 2.6 1.0 1 0 0 1 1 1 1 Somatotropin hormone family Prothymosin PF03247.12 001304875.1_01321001_1 - 5.4e-37 126.5 52.2 6e-37 126.4 52.2 1.0 1 0 0 1 1 1 1 Prothymosin/parathymosin family HCO3_cotransp PF00955.19 001081788.2_21027001_3 - 1.3e-189 631.3 20.0 1.9e-109 366.7 7.7 2.1 1 1 1 2 2 2 2 HCO3- transporter family Band_3_cyto PF07565.11 001081788.2_21027001_3 - 2.9e-84 282.9 0.0 5e-84 282.1 0.0 1.4 1 0 0 1 1 1 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.20 001081788.2_21027001_3 - 0.0038 17.0 0.0 0.0075 16.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 MFS_MOT1 PF16983.3 001081788.2_21027001_3 - 0.042 13.9 4.8 0.24 11.4 0.5 2.7 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily SYCE1 PF15233.4 001293223.2_32323001_2 - 3.2e-54 183.0 33.4 3.2e-54 183.0 33.4 2.6 1 1 1 2 2 2 1 Synaptonemal complex central element protein 1 DUF2833 PF11090.6 001293223.2_32323001_2 - 0.13 12.5 0.5 6.9 7.0 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2833) Phosphodiest PF01663.20 130772.1_26229120_1 - 2.8e-11 43.5 0.0 3.6e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Ribosomal_L15e PF00827.15 001304882.1_01322001_3 - 4.7e-98 326.4 3.4 5.4e-98 326.2 3.4 1.0 1 0 0 1 1 1 1 Ribosomal L15 Hepatitis_core PF00906.18 001304882.1_01322001_3 - 1.8 7.9 7.0 0.16 11.4 0.3 2.0 2 0 0 2 2 2 0 Hepatitis core antigen Ribosomal_L36e PF01158.16 001304858.1_01321001_2 - 1.4e-51 172.6 8.4 1.6e-51 172.4 8.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Interferon PF00143.17 001102443.1_22422001_1 - 1.8e-54 184.1 0.0 2e-54 184.0 0.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain V-set PF07686.15 001009253.1_22422001_1 - 3.1e-06 27.2 0.2 5.6e-06 26.4 0.2 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 001009253.1_22422001_1 - 5.3e-05 23.1 0.2 9.1e-05 22.3 0.2 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001009253.1_22422001_1 - 7.6e-05 23.1 0.1 0.00013 22.3 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain V-set_CD47 PF08204.9 001009253.1_22422001_1 - 0.0015 18.4 0.4 0.0021 17.9 0.4 1.1 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain ig PF00047.23 001009253.1_22422001_1 - 0.003 17.5 0.1 0.0053 16.8 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.3 001009253.1_22422001_1 - 0.012 15.6 0.1 0.024 14.5 0.1 1.7 1 1 0 1 1 1 0 Izumo-like Immunoglobulin domain Ig_2 PF13895.4 001009253.1_22422001_1 - 0.027 14.7 0.1 0.081 13.2 0.1 1.8 1 1 0 1 1 1 0 Immunoglobulin domain Fungal_lectin PF07938.10 001009253.1_22422001_1 - 0.069 12.4 0.1 0.082 12.1 0.1 1.1 1 0 0 1 1 1 0 Fungal fucose-specific lectin I-set PF07679.14 001009869.1_22426001_3 - 6.4e-81 266.4 8.5 4.6e-20 71.4 0.4 5.6 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.4 001009869.1_22426001_3 - 2.8e-70 232.8 11.7 1e-16 61.2 0.4 5.7 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 001009869.1_22426001_3 - 8.4e-54 179.6 4.9 9.8e-11 41.6 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 001009869.1_22426001_3 - 3.6e-44 148.9 4.2 7e-09 35.8 0.3 5.4 5 0 0 5 5 5 5 Immunoglobulin domain fn3 PF00041.19 001009869.1_22426001_3 - 5.8e-25 87.3 0.1 4.3e-12 46.1 0.0 3.0 2 0 0 2 2 2 2 Fibronectin type III domain V-set PF07686.15 001009869.1_22426001_3 - 8.2e-20 70.9 9.4 0.00063 19.7 0.0 7.6 5 4 0 5 5 5 4 Immunoglobulin V-set domain C1-set PF07654.13 001009869.1_22426001_3 - 2e-14 53.7 6.1 0.0024 18.2 0.1 5.6 5 0 0 5 5 5 4 Immunoglobulin C1-set domain Ig_5 PF16681.3 001009869.1_22426001_3 - 1.3e-11 44.7 3.5 0.0052 17.0 0.1 6.0 5 2 0 5 5 5 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 001009869.1_22426001_3 - 1.5e-10 40.9 13.6 0.0052 16.7 0.0 5.9 7 0 0 7 7 6 3 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 001009869.1_22426001_3 - 5.5e-10 39.0 0.3 0.41 10.6 0.0 5.2 5 0 0 5 5 5 4 Izumo-like Immunoglobulin domain Ig_4 PF16680.3 001009869.1_22426001_3 - 2e-08 34.3 5.1 1 9.6 0.1 6.6 5 1 0 5 5 5 2 T-cell surface glycoprotein CD3 delta chain Receptor_2B4 PF11465.6 001009869.1_22426001_3 - 0.00015 21.8 0.5 7.2 6.7 0.0 4.4 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 Herpes_gE PF02480.14 001009869.1_22426001_3 - 0.022 13.4 0.2 0.64 8.6 0.0 3.0 4 0 0 4 4 4 0 Alphaherpesvirus glycoprotein E Collagen_bind_2 PF12904.5 001009869.1_22426001_3 - 0.028 14.3 2.4 0.29 11.0 0.1 3.4 3 0 0 3 3 3 0 Putative collagen-binding domain of a collagenase Syndecan PF01034.18 001009869.1_22426001_3 - 1.4 8.8 4.6 37 4.2 0.0 2.5 2 0 0 2 2 2 0 Syndecan domain Pur_ac_phosph_N PF16656.3 001009869.1_22426001_3 - 3.3 8.2 10.2 0.86 10.1 0.1 4.3 5 2 0 5 5 4 0 Purple acid Phosphatase, N-terminal domain FGF PF00167.16 001114546.1_22423001_2 - 2.6e-42 143.7 0.0 4.4e-42 143.0 0.0 1.3 1 0 0 1 1 1 1 Fibroblast growth factor PAGK PF15284.4 001114546.1_22423001_3 - 0.099 12.4 0.1 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 Phage-encoded virulence factor V-set PF07686.15 001009229.1_22426001_2 - 5.9e-09 35.9 0.9 1.4e-08 34.7 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001009229.1_22426001_2 - 1.2e-07 32.1 1.9 0.0033 17.9 0.5 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001009229.1_22426001_2 - 0.00017 21.7 0.8 0.2 11.9 0.2 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001009229.1_22426001_2 - 0.0069 16.3 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain C2-set_2 PF08205.10 001009229.1_22426001_2 - 0.0075 16.2 0.5 0.017 15.0 0.2 1.7 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ABC_tran PF00005.25 001278944.1_32929001_1 - 5.5e-50 169.3 0.0 9.2e-25 87.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.5 001278944.1_32929001_1 - 1.7e-25 89.8 24.2 1.7e-25 89.8 24.2 1.8 2 0 0 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.4 001278944.1_32929001_1 - 4e-16 59.5 6.6 8.8e-05 22.3 0.0 5.3 5 0 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.4 001278944.1_32929001_1 - 1.4e-05 25.6 0.5 0.027 14.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.14 001278944.1_32929001_1 - 0.0014 18.4 0.2 0.15 11.9 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_29 PF13555.4 001278944.1_32929001_1 - 0.0016 18.0 0.9 0.1 12.2 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_15 PF13175.4 001278944.1_32929001_1 - 0.0018 17.8 0.8 1.1 8.6 0.0 3.2 3 0 0 3 3 3 2 AAA ATPase domain AAA_30 PF13604.4 001278944.1_32929001_1 - 0.0082 15.7 0.4 0.4 10.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.21 001278944.1_32929001_1 - 0.011 15.7 0.2 0.95 9.4 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase SRP54 PF00448.20 001278944.1_32929001_1 - 0.013 15.0 3.7 0.53 9.7 0.2 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF4162 PF13732.4 001278944.1_32929001_1 - 0.013 16.1 0.6 4.4 8.0 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) AAA_22 PF13401.4 001278944.1_32929001_1 - 0.015 15.4 0.1 9.3 6.4 0.0 2.9 2 0 0 2 2 2 0 AAA domain Arf PF00025.19 001278944.1_32929001_1 - 0.033 13.5 1.1 0.54 9.6 0.1 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_33 PF13671.4 001278944.1_32929001_1 - 0.15 12.1 0.0 19 5.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.17 001278944.1_32929001_1 - 0.23 10.7 0.8 13 5.0 0.0 3.6 4 1 1 5 5 5 0 RecF/RecN/SMC N terminal domain ABC2_membrane_2 PF12679.5 001278944.1_32929001_1 - 4.3 6.4 9.9 6.1 5.9 7.3 2.6 3 0 0 3 3 3 0 ABC-2 family transporter protein ABC2_membrane_3 PF12698.5 001278944.1_32929001_3 - 1.8e-20 73.2 22.4 2.7e-20 72.6 22.4 1.3 1 1 0 1 1 1 1 ABC-2 family transporter protein zf-H2C2_2 PF13465.4 001033159.2_32929001_2 - 9.3e-27 92.1 52.1 3.4e-07 30.3 0.9 8.7 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.24 001033159.2_32929001_2 - 6.8e-24 82.8 52.8 7.7e-05 22.8 0.5 8.1 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001033159.2_32929001_2 - 2e-14 52.9 50.5 0.0056 17.3 1.1 8.3 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001033159.2_32929001_2 - 7.1e-12 44.8 41.5 0.0046 16.7 3.0 6.7 6 0 0 6 6 6 5 C2H2-type zinc finger KRAB PF01352.25 001033159.2_32929001_2 - 2.8e-11 42.7 0.0 5.4e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 001033159.2_32929001_2 - 0.0012 18.9 34.5 0.39 10.9 1.2 6.4 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001033159.2_32929001_2 - 0.0023 18.1 41.7 0.0063 16.7 3.2 6.9 6 0 0 6 6 6 3 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.3 001033159.2_32929001_2 - 0.65 10.6 22.8 0.16 12.6 1.5 4.1 3 1 0 3 3 3 0 zinc-ribbon family zf-H2C2_2 PF13465.4 178732.3_32929001_2 - 1.6e-61 202.0 58.2 3.1e-08 33.6 0.2 10.8 10 0 0 10 10 10 9 Zinc-finger double domain zf-C2H2 PF00096.24 178732.3_32929001_2 - 1.6e-41 138.3 67.3 2.6e-05 24.3 1.2 10.0 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 178732.3_32929001_2 - 3.8e-22 76.9 66.5 0.0048 17.5 0.9 10.0 9 0 0 9 9 9 9 C2H2-type zinc finger KRAB PF01352.25 178732.3_32929001_2 - 1.3e-19 69.4 0.5 2.1e-19 68.8 0.5 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 178732.3_32929001_2 - 1e-07 31.6 53.8 0.14 12.0 0.2 10.0 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 178732.3_32929001_2 - 2.9e-07 30.5 25.8 0.007 16.5 0.1 7.7 8 0 0 8 8 8 3 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 178732.3_32929001_2 - 7.7e-06 25.8 33.3 0.069 13.2 1.4 6.3 5 1 1 6 6 6 4 Zinc ribbon domain zinc_ribbon_15 PF17032.3 178732.3_32929001_2 - 0.011 16.3 21.2 1.3 9.7 0.7 4.8 1 1 5 6 6 6 0 zinc-ribbon family HypA PF01155.17 178732.3_32929001_2 - 0.19 11.6 20.4 1.8 8.5 2.8 4.4 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA BolA PF01722.16 178732.3_32929001_2 - 0.25 11.5 8.8 0.31 11.2 2.4 2.9 2 1 1 3 3 3 0 BolA-like protein GAGA PF09237.9 178732.3_32929001_2 - 0.29 10.9 9.3 19 5.0 0.2 4.8 3 1 1 4 4 4 0 GAGA factor Trm112p PF03966.14 178732.3_32929001_2 - 0.68 10.4 4.9 89 3.6 0.1 3.8 3 0 0 3 3 3 0 Trm112p-like protein RNase_T PF00929.22 020583.5_32923001_1 - 5.8e-16 59.3 0.0 7.6e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.18 020583.5_32923001_1 - 0.041 13.5 0.2 0.25 11.0 0.2 2.3 1 1 0 1 1 1 0 3'-5' exonuclease RasGEF_N PF00618.18 001101463.1_32923001_1 - 4.1e-08 33.3 0.6 8.7e-08 32.2 0.6 1.5 1 0 0 1 1 1 1 RasGEF N-terminal motif ANF_receptor PF01094.26 175674.3_32925001_1 - 8.1e-81 271.7 0.0 9.8e-81 271.4 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 175674.3_32925001_1 - 5.7e-50 170.1 23.7 9.1e-50 169.5 23.7 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 175674.3_32925001_1 - 8.7e-15 54.3 11.3 8.7e-15 54.3 11.3 2.1 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 175674.3_32925001_1 - 2.9e-07 30.4 0.0 4.4e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein DUF515 PF04415.10 175674.3_32925001_1 - 0.024 12.9 0.2 2.5 6.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF515) zf-H2C2_2 PF13465.4 001164689.1_32928001_1 - 4.2e-133 428.3 158.0 2e-09 37.3 2.6 21.6 22 0 0 22 22 22 19 Zinc-finger double domain zf-C2H2 PF00096.24 001164689.1_32928001_1 - 5.2e-77 250.1 159.4 6.3e-06 26.2 0.9 21.4 22 0 0 22 22 21 17 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001164689.1_32928001_1 - 6.4e-50 163.3 144.6 0.00015 22.2 0.9 20.8 20 0 0 20 20 20 16 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001164689.1_32928001_1 - 5.8e-42 140.8 127.0 5e-05 23.0 1.3 18.4 18 0 0 18 18 18 17 C2H2-type zinc finger KRAB PF01352.25 001164689.1_32928001_1 - 4.4e-21 74.1 0.2 8.6e-21 73.2 0.2 1.5 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 001164689.1_32928001_1 - 1.3e-10 41.1 103.3 0.055 13.5 3.2 13.4 6 3 13 19 19 18 14 Zinc ribbon domain XPA_N PF01286.16 001164689.1_32928001_1 - 1.4e-06 28.1 68.4 5.1 7.1 0.1 16.6 17 0 0 17 17 16 3 XPA protein N-terminal zinc_ribbon_15 PF17032.3 001164689.1_32928001_1 - 2e-06 28.3 80.1 0.17 12.5 2.9 9.1 4 3 5 9 9 9 6 zinc-ribbon family DUF3268 PF11672.6 001164689.1_32928001_1 - 7.7e-05 22.9 67.2 0.1 12.8 0.7 8.9 3 1 9 13 13 13 9 zinc-finger-containing domain FYVE PF01363.19 001164689.1_32928001_1 - 0.0021 18.0 85.8 0.079 13.0 10.6 9.3 2 1 4 6 6 5 3 FYVE zinc finger zf-C2H2_jaz PF12171.6 001164689.1_32928001_1 - 0.0081 16.3 0.9 0.0081 16.3 0.9 19.0 20 0 0 20 20 20 6 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 001164689.1_32928001_1 - 0.019 14.6 86.4 0.21 11.3 0.1 16.4 18 0 0 18 18 18 0 zinc-finger C2H2-type zf-trcl PF13451.4 001164689.1_32928001_1 - 1.5 8.6 78.9 3.4 7.5 3.1 15.4 13 5 1 14 14 13 0 Probable zinc-ribbon domain C1_4 PF07975.10 001164689.1_32928001_1 - 5.2 7.3 93.7 0.53 10.5 4.5 11.3 4 2 13 17 17 15 0 TFIIH C1-like domain GATA PF00320.25 001164689.1_32928001_1 - 7.4 6.1 74.6 7.2 6.2 0.1 14.4 10 3 6 16 16 16 0 GATA zinc finger CtkA_N PF16948.3 001164689.1_32928001_2 - 0.0023 17.7 2.3 5.8 6.8 0.1 5.0 4 0 0 4 4 4 2 Cell translocating kinase A N-terminus MarR PF01047.20 001164689.1_32928001_2 - 0.71 9.7 3.7 21 5.0 0.1 5.2 8 0 0 8 8 8 0 MarR family zf-H2C2_2 PF13465.4 001164689.1_32928001_3 - 1.2 9.6 5.9 11 6.6 0.1 3.5 3 0 0 3 3 3 0 Zinc-finger double domain Pro-rich PF15240.4 001244628.1_32922001_2 - 0.00049 20.4 33.5 0.0019 18.5 33.5 1.8 1 1 0 1 1 1 1 Proline-rich IncA PF04156.12 001244628.1_32922001_2 - 0.012 15.3 0.7 0.016 14.9 0.7 1.3 1 0 0 1 1 1 0 IncA protein zf-H2C2_2 PF13465.4 001081431.1_32924001_1 - 7e-41 136.8 48.4 2.4e-09 37.1 0.8 8.5 8 0 0 8 8 8 7 Zinc-finger double domain SCAN PF02023.15 001081431.1_32924001_1 - 9.6e-39 131.0 1.9 1.7e-38 130.2 1.9 1.4 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 001081431.1_32924001_1 - 4e-36 121.4 50.4 3.9e-08 33.2 0.7 7.5 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001081431.1_32924001_1 - 1.6e-18 65.6 48.5 0.00011 22.5 0.5 7.7 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001081431.1_32924001_1 - 3.1e-06 27.2 21.9 0.073 13.3 0.0 7.2 7 0 0 7 7 7 1 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 001081431.1_32924001_1 - 9e-06 25.6 22.8 0.001 19.0 0.6 4.7 2 1 3 5 5 5 4 Zinc ribbon domain zf-C2H2_6 PF13912.4 001081431.1_32924001_1 - 2.6e-05 23.9 44.9 0.012 15.4 0.4 7.8 7 1 0 7 7 7 5 C2H2-type zinc finger KRAB PF01352.25 001081431.1_32924001_1 - 0.0021 17.6 0.0 0.0048 16.4 0.0 1.5 1 0 0 1 1 1 1 KRAB box FYDLN_acid PF09538.8 001081431.1_32924001_1 - 0.0028 18.2 9.1 3 8.4 1.6 4.5 2 2 3 5 5 5 1 Protein of unknown function (FYDLN_acid) zf-Di19 PF05605.10 001081431.1_32924001_1 - 0.019 15.1 20.3 0.5 10.6 0.9 4.6 2 1 2 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.4 001081431.1_32924001_1 - 0.026 14.3 20.7 0.088 12.6 0.5 4.8 5 0 0 5 5 4 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.3 001081431.1_32924001_1 - 0.083 12.5 24.8 0.89 9.2 0.2 5.7 6 0 0 6 6 5 0 zinc-finger C2H2-type zinc_ribbon_9 PF14369.4 001081431.1_32924001_1 - 0.17 12.0 8.8 15 5.8 0.3 4.6 4 0 0 4 4 4 0 zinc-ribbon zf-met PF12874.5 001081431.1_32924001_1 - 0.59 10.5 29.7 0.72 10.2 0.3 6.6 6 0 0 6 6 6 0 Zinc-finger of C2H2 type DZR PF12773.5 001081431.1_32924001_1 - 1.8 8.5 20.8 1.6e+04 -7.6 20.8 4.0 1 1 0 1 1 0 0 Double zinc ribbon zf-LYAR PF08790.9 001081431.1_32924001_1 - 3.2 7.6 18.3 5.3 6.9 0.1 6.7 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger zinc_ribbon_15 PF17032.3 001081431.1_32924001_1 - 6.7 7.4 18.3 3.7 8.2 0.3 3.9 2 1 3 5 5 4 0 zinc-ribbon family CENP-K PF11802.6 075088.1_32923120_1 - 1.6e-25 90.1 4.0 2.4e-25 89.5 4.0 1.2 1 0 0 1 1 1 1 Centromere-associated protein K CENP-K PF11802.6 075088.1_32923120_2 - 2.9e-88 295.7 7.3 4e-88 295.3 7.3 1.1 1 0 0 1 1 1 1 Centromere-associated protein K HIP1_clath_bdg PF16515.3 075088.1_32923120_2 - 0.18 12.3 5.3 0.37 11.3 5.3 1.5 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 KLRAQ PF10205.7 075088.1_32923120_2 - 0.2 11.8 5.7 0.41 10.8 5.7 1.4 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein DUF3780 PF12635.5 104355.1_32926120_1 - 0.057 13.1 0.4 0.09 12.4 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3780) CHCH PF06747.11 104355.1_32926120_3 - 0.012 15.6 3.8 0.039 13.9 3.8 2.0 1 0 0 1 1 1 0 CHCH domain MTCP1 PF08991.8 104355.1_32926120_3 - 0.014 15.5 0.9 0.041 14.0 0.9 1.8 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type zf-C2H2_8 PF15909.3 034153.1_32923120_2 - 6.4e-57 189.8 9.8 9.5e-57 189.2 9.8 1.2 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2 PF00096.24 034153.1_32923120_2 - 0.00044 20.4 16.2 0.39 11.1 0.1 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 034153.1_32923120_2 - 0.00081 19.9 15.0 0.26 12.1 0.5 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.4 034153.1_32923120_2 - 0.0017 18.1 11.0 0.58 10.0 0.3 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.4 034153.1_32923120_2 - 0.37 11.2 5.9 3.2 8.2 1.1 2.9 2 0 0 2 2 2 0 Zinc-finger double domain IL8 PF00048.18 034153.1_32923120_3 - 0.07 13.2 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Small cytokines (intecrine/chemokine), interleukin-8 like PRR18 PF15671.3 028280.1_32927120_3 - 2.7e-134 447.0 19.0 5.3e-134 446.0 19.0 1.5 1 0 0 1 1 1 1 Proline-rich protein family 18 Peptidase_C65 PF10275.7 033587.1_32927120_2 - 3.7e-74 249.2 5.0 4.5e-74 248.9 5.0 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.17 033587.1_32927120_2 - 0.025 15.0 0.1 0.78 10.1 0.1 2.2 2 0 0 2 2 2 0 OTU-like cysteine protease FXa_inhibition PF14670.4 033587.1_32927120_3 - 3.3 7.9 8.2 13 6.0 2.1 3.2 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site Chromosome_seg PF13889.4 045567.1_32927120_2 - 1.3e-17 63.5 0.2 2.5e-17 62.6 0.2 1.5 1 0 0 1 1 1 1 Chromosome segregation during meiosis DUF4210 PF13915.4 045567.1_32927120_2 - 1.3e-13 51.2 0.0 2.6e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) ART PF01129.16 111935.1_32923120_1 - 6.2e-11 41.9 0.0 9.2e-11 41.3 0.0 1.2 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ART PF01129.16 111935.1_32923120_3 - 1.2e-31 109.6 0.0 1.7e-31 109.1 0.0 1.1 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase SEP PF08059.11 045571.1_32923120_1 - 1.3e-12 48.0 0.0 3e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 SEP domain FAM76 PF16046.3 045571.1_32923120_1 - 0.00047 19.5 1.0 0.00072 18.9 1.0 1.2 1 0 0 1 1 1 1 FAM76 protein IncA PF04156.12 045571.1_32923120_1 - 0.0048 16.6 4.7 0.0066 16.1 4.7 1.2 1 0 0 1 1 1 1 IncA protein DUF1635 PF07795.9 045571.1_32923120_1 - 0.012 15.4 3.6 0.018 14.9 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) MnmE_helical PF12631.5 045571.1_32923120_1 - 0.034 14.2 0.3 0.048 13.7 0.3 1.2 1 0 0 1 1 1 0 MnmE helical domain Exonuc_VII_L PF02601.13 045571.1_32923120_1 - 0.13 11.7 0.7 0.17 11.3 0.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit TMPIT PF07851.11 045571.1_32923120_1 - 0.5 9.4 4.9 0.7 8.9 4.9 1.1 1 0 0 1 1 1 0 TMPIT-like protein OmpH PF03938.12 045571.1_32923120_1 - 0.58 10.0 12.8 0.96 9.3 12.8 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Mnd1 PF03962.13 045571.1_32923120_1 - 4.6 6.9 10.1 7 6.3 10.1 1.2 1 0 0 1 1 1 0 Mnd1 family UPF0242 PF06785.9 045571.1_32923120_1 - 5.3 5.5 5.6 7.5 5.0 5.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) UBX PF00789.18 045571.1_32923120_3 - 1.1e-05 25.4 0.0 1.7e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 UBX domain PTS_2-RNA PF01885.14 027351.1_32922120_2 - 5.6e-05 23.1 0.0 7.6e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family PTS_2-RNA PF01885.14 027351.1_32922120_3 - 7.6e-30 104.2 0.0 1e-29 103.8 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Sema PF01403.17 073551.1_32928120_2 - 1.8e-108 363.0 0.0 2.4e-108 362.5 0.0 1.1 1 0 0 1 1 1 1 Sema domain Nudix_N_2 PF14803.4 040620.1_32921120_1 - 0.18 11.6 0.1 0.18 11.6 0.1 1.5 2 0 0 2 2 2 0 Nudix N-terminal zf-C2H2 PF00096.24 030677.1_32924120_1 - 6.9e-15 54.5 23.7 8.7e-07 28.9 0.7 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 030677.1_32924120_1 - 2.3e-13 49.8 27.7 5.4e-06 26.5 0.2 7.1 7 0 0 7 7 7 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 030677.1_32924120_1 - 1.6e-10 40.7 29.8 0.00028 21.3 0.7 5.4 5 0 0 5 5 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 030677.1_32924120_1 - 2.2e-05 24.5 18.0 0.023 14.9 0.1 4.1 4 0 0 4 4 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 030677.1_32924120_1 - 6.4e-05 22.7 18.2 0.0011 18.7 1.2 4.4 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_11 PF16622.3 030677.1_32924120_1 - 0.00021 20.8 2.5 0.00021 20.8 2.5 4.0 4 0 0 4 4 4 1 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 030677.1_32924120_1 - 0.02 14.9 8.8 0.067 13.2 2.8 3.1 2 1 1 3 3 3 0 Zinc ribbon domain XPA_N PF01286.16 030677.1_32924120_1 - 0.064 13.2 9.1 1.8 8.6 0.3 3.5 3 0 0 3 3 3 0 XPA protein N-terminal ADK_lid PF05191.12 030677.1_32924120_1 - 0.26 11.2 2.6 12 5.9 0.2 2.5 2 0 0 2 2 2 0 Adenylate kinase, active site lid zf-C2HE PF16278.3 030677.1_32924120_1 - 0.48 10.8 11.8 4.5 7.7 0.4 3.4 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_15 PF17032.3 030677.1_32924120_1 - 0.63 10.7 8.6 1.4 9.6 4.5 2.4 1 1 1 2 2 2 0 zinc-ribbon family zf-LYAR PF08790.9 030677.1_32924120_1 - 1.5 8.7 9.3 4.8 7.0 0.4 3.4 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-FCS PF06467.12 030677.1_32924120_1 - 2.1 8.2 5.4 33 4.4 0.2 3.5 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2_2 PF12756.5 030677.1_32924120_1 - 2.6 8.3 13.9 52 4.1 1.9 3.3 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.5 030677.1_32924120_1 - 3.2 8.1 25.1 0.86 9.9 0.4 5.3 5 0 0 5 5 5 0 Zinc-finger of C2H2 type PHD PF00628.27 030677.1_32924120_1 - 4.9 7.0 9.0 0.59 9.9 0.2 2.9 2 1 0 2 2 2 0 PHD-finger C1_1 PF00130.20 030677.1_32924120_1 - 5.5 6.8 12.0 14 5.6 0.3 3.5 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Cupin_8 PF13621.4 104353.1_32929120_1 - 6.9e-49 166.8 0.0 1.1e-48 166.1 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain PLA2_B PF01735.16 104353.1_32929120_1 - 1.5e-27 96.0 0.0 4.8e-27 94.4 0.0 1.7 2 0 0 2 2 2 1 Lysophospholipase catalytic domain C2 PF00168.28 104353.1_32929120_1 - 3.5e-20 72.1 0.1 8.8e-20 70.8 0.1 1.6 1 0 0 1 1 1 1 C2 domain Cupin_8 PF13621.4 104353.1_32929120_2 - 6.4e-24 85.0 0.2 9.2e-24 84.5 0.2 1.1 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.20 104353.1_32929120_2 - 0.071 13.4 0.1 0.14 12.5 0.1 1.4 1 0 0 1 1 1 0 JmjC domain, hydroxylase YMF19 PF02326.13 036596.1_32922120_1 - 0.12 13.0 2.1 0.67 10.6 0.4 2.1 2 0 0 2 2 2 0 Plant ATP synthase F0 PAN_1 PF00024.24 036596.1_32922120_3 - 0.11 12.4 0.4 0.15 11.9 0.4 1.2 1 0 0 1 1 1 0 PAN domain NAD_Gly3P_dh_N PF01210.21 003953.1_32923120_2 - 1.5e-46 158.1 0.1 2.5e-46 157.4 0.1 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.12 003953.1_32923120_2 - 1.2e-44 151.8 0.0 2e-44 151.2 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.15 003953.1_32923120_2 - 0.0066 16.9 0.2 0.12 12.8 0.1 2.8 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent hEGF PF12661.5 038000.1_32924120_3 - 5.7 7.6 11.2 16 6.2 1.2 4.0 3 0 0 3 3 3 0 Human growth factor-like EGF EGF PF00008.25 038000.1_32924120_3 - 8 6.7 12.4 12 6.1 0.4 3.9 4 0 0 4 4 4 0 EGF-like domain EF-hand_7 PF13499.4 036629.1_32923120_2 - 0.00012 22.3 0.2 0.00021 21.5 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.4 036629.1_32923120_2 - 0.00036 20.1 0.2 0.00054 19.5 0.2 1.3 1 0 0 1 1 1 1 EF-hand domain pair DUF2209 PF09974.7 040357.1_32922120_3 - 0.057 13.6 0.0 0.08 13.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Ribosomal_L22 PF00237.17 033522.1_32924120_2 - 3.8e-35 120.3 0.0 5.8e-35 119.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Takusan PF04822.11 045059.1_32925120_3 - 7.1e-05 22.5 1.7 0.00015 21.5 1.7 1.5 1 0 0 1 1 1 1 Takusan Arf PF00025.19 033324.1_32927120_3 - 3.8e-21 75.2 0.1 6e-21 74.5 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 033324.1_32927120_3 - 0.0016 17.8 0.0 0.0024 17.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 033324.1_32927120_3 - 0.0072 16.4 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 033324.1_32927120_3 - 0.035 13.6 0.0 0.054 13.0 0.0 1.2 1 0 0 1 1 1 0 Ras family Myosin_N PF02736.17 046191.1_32921120_2 - 0.058 13.1 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain Ribosomal_L37ae PF01780.17 027984.1_32923120_1 - 1.8e-11 43.9 0.3 3.5e-11 42.9 0.3 1.5 1 0 0 1 1 1 1 Ribosomal L37ae protein family Defensin_propep PF00879.16 003146.1_32921120_1 - 5.8e-22 77.6 0.2 7.3e-22 77.3 0.2 1.1 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 003146.1_32921120_1 - 7.1e-07 29.5 10.2 9.3e-07 29.1 10.2 1.2 1 0 0 1 1 1 1 Mammalian defensin MF_alpha_N PF05436.9 003146.1_32921120_1 - 0.0062 16.3 0.0 0.0078 16.0 0.0 1.2 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus DUF4078 PF13300.4 126484.1_32924120_1 - 0.14 12.3 0.5 0.25 11.5 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4078) Cadherin PF00028.15 030708.1_32929120_1 - 8.9e-09 35.6 0.0 2.4e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Cadherin domain FAM27 PF15832.3 030708.1_32929120_1 - 1.3 9.5 13.5 2.6 8.5 13.5 1.5 1 0 0 1 1 1 0 FAM27 D and E protein family Cadherin PF00028.15 030708.1_32929120_2 - 4.5e-15 55.7 0.0 7.9e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 Cadherin domain UBA_4 PF14555.4 030708.1_32929120_2 - 5.8e-08 32.3 0.1 9.7e-08 31.6 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain Takusan PF04822.11 073362.1_32923120_3 - 1.4e-25 88.8 5.6 2.3e-25 88.2 5.6 1.3 1 0 0 1 1 1 1 Takusan DUF4355 PF14265.4 073362.1_32923120_3 - 0.021 15.0 0.9 0.021 15.0 0.9 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) Hrs_helical PF12210.6 073362.1_32923120_3 - 0.057 13.8 1.7 0.12 12.7 1.7 1.5 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Caerin_1 PF07440.10 027843.1_32924120_3 - 0.55 10.2 3.4 1.6 8.8 3.4 1.7 1 0 0 1 1 1 0 Caerin 1 protein Rhodanese PF00581.18 130781.1_32928120_1 - 1.3e-10 41.6 0.0 2.4e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain CENP-L PF13092.4 131029.1_32925120_1 - 2.3e-32 112.3 0.1 3.1e-32 111.9 0.1 1.2 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 DUF1534 PF07551.9 131029.1_32925120_3 - 0.18 11.4 0.8 0.32 10.6 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1534) Filament PF00038.19 029393.1_26225120_1 - 1.3e-23 83.9 2.7 1.3e-23 83.9 2.7 1.4 2 0 0 2 2 2 1 Intermediate filament protein MtrE PF04206.10 029393.1_26225120_1 - 0.015 14.5 3.9 0.02 14.1 3.9 1.1 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit E Filament PF00038.19 029393.1_26225120_2 - 9.2e-06 25.3 0.2 9.2e-06 25.3 0.2 1.6 2 0 0 2 2 2 1 Intermediate filament protein Filament PF00038.19 029393.1_26225120_3 - 7e-60 203.1 2.4 7e-60 203.1 2.4 1.5 2 0 0 2 2 2 1 Intermediate filament protein SR-25 PF10500.7 029393.1_26225120_3 - 0.041 13.4 30.8 0.06 12.8 30.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RNase_H2-Ydr279 PF09468.8 029393.1_26225120_3 - 0.91 8.9 14.3 1.4 8.3 14.3 1.3 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Keratin_2_head PF16208.3 029393.1_26225120_3 - 7.4 6.6 33.4 14 5.7 33.4 1.4 1 0 0 1 1 1 0 Keratin type II head zf-H2C2_2 PF13465.4 036573.1_26227120_1 - 0.27 11.6 0.1 0.27 11.6 0.1 3.8 4 0 0 4 4 4 0 Zinc-finger double domain zf-C2H2 PF00096.24 036573.1_26227120_1 - 2.3 8.7 8.2 55 4.4 0.1 4.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-FPG_IleRS PF06827.12 036573.1_26227120_1 - 7.1 6.5 18.4 2.9 7.7 0.3 4.6 4 0 0 4 4 4 0 Zinc finger found in FPG and IleRS zf-H2C2_2 PF13465.4 036573.1_26227120_3 - 2.1e-06 27.8 44.1 0.00072 19.8 1.6 6.0 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2 PF00096.24 036573.1_26227120_3 - 2.3e-05 24.5 0.6 2.3e-05 24.5 0.6 4.6 4 1 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 036573.1_26227120_3 - 0.05 13.4 0.1 0.05 13.4 0.1 3.6 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_4 PF13894.4 036573.1_26227120_3 - 0.057 14.1 23.4 0.16 12.8 0.5 4.9 4 0 0 4 4 4 0 C2H2-type zinc finger DUF899 PF05988.10 036573.1_26227120_3 - 0.32 10.3 1.7 0.54 9.6 1.7 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF899) zf-C2HE PF16278.3 036573.1_26227120_3 - 0.73 10.2 10.8 3.7 8.0 1.7 2.6 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger V-set PF07686.15 001302774.1_39723001_1 - 0.0085 16.1 0.3 0.014 15.4 0.3 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Filament PF00038.19 002872.1_32921120_1 - 3.4e-06 26.7 0.0 4.3e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein ELK PF03789.11 002872.1_32921120_1 - 0.092 12.7 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 ELK domain AFT PF08731.9 002872.1_32921120_2 - 0.014 15.7 0.5 0.019 15.2 0.5 1.2 1 0 0 1 1 1 0 Transcription factor AFT Tweety PF04906.11 126418.1_26222120_1 - 0.12 10.9 3.1 0.16 10.5 3.1 1.2 1 0 0 1 1 1 0 Tweety PEX11 PF05648.12 153403.1_32925120_3 - 1.9e-48 164.8 0.1 2.6e-48 164.3 0.1 1.1 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) OATP PF03137.18 001317251.1_21025001_3 - 7.1e-163 542.7 16.4 7.1e-163 542.7 16.4 1.4 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 001317251.1_21025001_3 - 8.8e-18 64.2 26.9 3.4e-16 59.0 6.4 3.0 3 0 0 3 3 3 2 Major Facilitator Superfamily Kazal_2 PF07648.13 001317251.1_21025001_3 - 4.2e-11 42.7 5.2 1e-10 41.4 5.2 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 001317251.1_21025001_3 - 0.0019 18.1 5.2 0.0047 16.8 5.2 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain TauE PF01925.17 001317251.1_21025001_3 - 0.63 9.5 16.3 0.11 12.0 0.2 3.6 4 1 0 4 4 4 0 Sulfite exporter TauE/SafE Interferon PF00143.17 001099440.1_21022001_1 - 8.6e-55 185.2 4.0 9.8e-55 185.0 4.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain KAR9 PF08580.8 001099440.1_21022001_1 - 0.18 10.2 1.1 0.21 9.9 1.1 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Methyltransf_3 PF01596.15 001081834.2_21023001_2 - 1.1e-20 73.6 0.0 1.5e-20 73.2 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.4 001081834.2_21023001_2 - 6.8e-12 46.2 0.0 1.1e-11 45.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.10 001081834.2_21023001_2 - 0.0082 15.7 0.0 0.015 14.8 0.0 1.4 2 0 0 2 2 2 1 Cephalosporin hydroxylase Methyltransf_15 PF09445.8 001081834.2_21023001_2 - 0.027 14.1 0.0 0.039 13.6 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_31 PF13847.4 001081834.2_21023001_2 - 0.054 13.2 0.0 0.095 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.17 001081834.2_21023001_2 - 0.099 12.2 0.0 0.15 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GTP_EFTU PF00009.25 001257105.1_21025001_2 - 3.8e-46 156.9 0.0 8.1e-46 155.9 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 001257105.1_21025001_2 - 1.4e-29 102.5 0.1 1.4e-29 102.5 0.1 2.9 4 0 0 4 4 4 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.23 001257105.1_21025001_2 - 8.9e-08 32.3 0.0 2.2e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 PAM2 PF07145.13 001257105.1_21025001_2 - 1.4e-06 27.5 9.3 3.5e-05 23.0 0.7 3.0 2 1 1 3 3 3 2 Ataxin-2 C-terminal region MMR_HSR1 PF01926.21 001257105.1_21025001_2 - 0.003 17.5 0.1 0.012 15.6 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Ig_3 PF13927.4 001098795.2_21023001_1 - 1.1e-11 45.1 0.4 1.7e-08 34.8 0.3 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001098795.2_21023001_1 - 3.5e-08 33.6 0.0 0.00014 22.0 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001098795.2_21023001_1 - 4.6e-08 32.9 0.1 3.1e-06 27.0 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.23 001098795.2_21023001_1 - 3.2e-05 23.9 0.3 0.055 13.5 0.5 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001098795.2_21023001_1 - 4.1e-05 23.6 0.5 0.0086 16.1 0.4 2.7 2 1 0 2 2 2 1 Immunoglobulin V-set domain SH2 PF00017.22 001098795.2_21023001_1 - 0.085 12.8 0.0 0.25 11.3 0.0 1.8 2 1 0 2 2 2 0 SH2 domain APOBEC_N PF08210.9 001242451.1_21022001_1 - 1.1e-37 129.6 1.0 1.3e-37 129.4 1.0 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001242451.1_21022001_1 - 8.2e-31 105.7 0.2 1.3e-30 105.0 0.2 1.3 1 0 0 1 1 1 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001242451.1_21022001_1 - 6.7e-05 22.6 0.0 9.7e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.4 001242451.1_21022001_1 - 0.001 18.7 0.1 0.0016 18.1 0.1 1.3 1 0 0 1 1 1 1 MafB19-like deaminase Toxin-deaminase PF14424.4 001242451.1_21022001_1 - 0.0045 17.0 0.2 0.0057 16.6 0.2 1.3 1 0 0 1 1 1 1 The BURPS668_1122 family of deaminases Defensin_propep PF00879.16 001166094.1_21021001_1 - 7e-19 67.8 0.2 1e-18 67.3 0.2 1.2 1 0 0 1 1 1 1 Defensin propeptide MIP PF00230.18 001114531.1_21022001_1 - 2.9e-82 275.6 9.7 3.4e-82 275.4 9.7 1.0 1 0 0 1 1 1 1 Major intrinsic protein Rick_17kDa_Anti PF05433.13 001114531.1_21022001_1 - 0.064 13.0 1.8 15 5.5 0.0 2.9 2 0 0 2 2 2 0 Glycine zipper 2TM domain DUF1799 PF08809.9 001114531.1_21022001_2 - 0.17 11.9 1.5 0.28 11.2 1.5 1.3 1 0 0 1 1 1 0 Phage related hypothetical protein (DUF1799) 7tm_1 PF00001.19 001091534.1_21023001_1 - 5.8e-49 166.6 17.4 9.5e-49 165.9 17.4 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001091534.1_21023001_1 - 6.1e-07 28.9 15.4 8.2e-07 28.5 15.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1467 PF07330.10 001091534.1_21023001_1 - 0.073 12.9 0.5 0.073 12.9 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1467) 7TM_GPCR_Srx PF10328.7 001091534.1_21023001_1 - 0.11 11.7 14.4 0.024 13.8 10.9 1.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srab PF10292.7 001091534.1_21023001_1 - 0.13 11.0 13.3 0.14 11.0 3.5 2.4 1 1 1 2 2 2 0 Serpentine type 7TM GPCR receptor class ab chemoreceptor 7tm_4 PF13853.4 001091534.1_21023001_1 - 0.73 9.4 16.4 6.9 6.2 16.4 2.2 1 1 0 1 1 1 0 Olfactory receptor TMEM192 PF14802.4 001091534.1_21023001_1 - 2 7.3 7.1 0.11 11.4 0.7 2.0 2 0 0 2 2 2 0 TMEM192 family Actin PF00022.17 001317258.1_21023001_3 - 4.5e-150 499.7 0.0 1.4e-149 498.0 0.0 1.6 1 1 0 1 1 1 1 Actin Methyltransf_3 PF01596.15 001114535.2_21023001_2 - 1.1e-20 73.6 0.0 1.5e-20 73.2 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.4 001114535.2_21023001_2 - 6.8e-12 46.2 0.0 1.1e-11 45.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.10 001114535.2_21023001_2 - 0.0082 15.7 0.0 0.015 14.8 0.0 1.4 2 0 0 2 2 2 1 Cephalosporin hydroxylase Methyltransf_15 PF09445.8 001114535.2_21023001_2 - 0.027 14.1 0.0 0.039 13.6 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_31 PF13847.4 001114535.2_21023001_2 - 0.054 13.2 0.0 0.095 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.17 001114535.2_21023001_2 - 0.099 12.2 0.0 0.15 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Basic PF01586.14 001317253.1_21023001_3 - 1e-29 103.4 0.2 3e-29 101.9 0.2 1.8 1 0 0 1 1 1 1 Myogenic Basic domain Myf5 PF12232.6 001317253.1_21023001_3 - 2.3e-24 85.8 5.5 5.2e-24 84.7 5.5 1.6 1 0 0 1 1 1 1 Myogenic determination factor 5 HLH PF00010.24 001317253.1_21023001_3 - 1.6e-14 53.5 2.3 2.7e-14 52.7 2.3 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SRF-TF PF00319.16 001317255.1_21024001_2 - 6.4e-24 83.0 0.4 1.1e-23 82.3 0.4 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 001317255.1_21024001_2 - 6.1e-19 67.7 0.4 6.1e-19 67.7 0.4 3.4 4 0 0 4 4 4 1 Holliday junction regulator protein family C-terminal repeat TFIIA PF03153.11 001317255.1_21024001_2 - 9.1 6.0 18.8 14 5.4 18.8 1.5 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TGF_beta PF00019.18 001081910.2_21023001_3 - 1.5e-14 54.6 0.0 3.1e-14 53.6 0.0 1.6 1 1 0 1 1 1 1 Transforming growth factor beta like domain SAM_2 PF07647.15 153382.1_32929120_1 - 0.00022 21.1 0.0 0.00058 19.8 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) START PF01852.17 153382.1_32929120_3 - 8.6e-39 133.0 0.2 1.3e-38 132.4 0.2 1.2 1 0 0 1 1 1 1 START domain RhoGAP PF00620.25 153382.1_32929120_3 - 2.4e-32 111.7 0.9 4.1e-32 111.0 0.9 1.3 1 0 0 1 1 1 1 RhoGAP domain ALIX_LYPXL_bnd PF13949.4 153382.1_32929120_3 - 0.14 11.3 0.5 0.21 10.7 0.5 1.2 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV Bromo_TP PF07524.11 022015.4_32926001_2 - 1.4e-29 101.7 0.3 2.7e-29 100.8 0.2 1.5 2 0 0 2 2 2 1 Bromodomain associated TAF8_C PF10406.7 022015.4_32926001_2 - 2.2e-22 79.2 2.5 5.9e-22 77.8 2.5 1.8 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term TFIID-31kDa PF02291.13 022015.4_32926001_2 - 0.00029 20.8 0.0 0.00053 19.9 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP_like PF17027.3 022015.4_32926001_2 - 0.00077 19.5 0.0 0.0013 18.8 0.0 1.3 1 0 0 1 1 1 1 Histone-fold protein DUF3090 PF11290.6 022015.4_32926001_2 - 0.087 12.5 1.1 0.16 11.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3090) SH2 PF00017.22 001123379.1_21022001_1 - 3.4e-10 39.7 0.0 6e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.14 001123379.1_21022001_1 - 4e-05 23.7 0.0 9.1e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 SOCS box Xlink PF00193.15 001039150.1_32929001_2 - 8.8e-19 67.6 0.0 1.8e-18 66.5 0.0 1.6 1 0 0 1 1 1 1 Extracellular link domain 7tm_1 PF00001.19 001164012.1_21023001_1 - 1.1e-72 244.4 0.0 1.6e-72 243.8 0.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001164012.1_21023001_1 - 2.6e-15 56.4 3.7 2.3e-10 40.2 1.1 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001164012.1_21023001_1 - 9.5e-10 38.5 4.2 9.9e-08 31.9 3.2 2.1 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001164012.1_21023001_1 - 2.5e-07 30.2 5.0 2.5e-07 30.2 5.0 2.3 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF2157 PF09925.7 001164012.1_21023001_1 - 0.0075 15.9 3.4 0.0077 15.9 0.0 2.5 2 1 0 2 2 2 1 Predicted membrane protein (DUF2157) DUF3682 PF12446.6 001164012.1_21023001_1 - 1.5 9.2 18.4 2.3 8.5 18.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) PET PF06297.12 001134461.1_32929001_2 - 2.6e-37 126.9 0.7 5.5e-37 125.8 0.7 1.6 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 001134461.1_32929001_2 - 2.6e-22 78.7 53.7 1.3e-09 38.0 13.8 4.8 4 0 0 4 4 4 3 LIM domain LIM PF00412.20 001161769.1_32923001_3 - 6.4e-30 103.0 17.6 6.4e-16 58.2 1.2 2.9 3 0 0 3 3 3 2 LIM domain RA PF00788.21 001251988.1_39724001_1 - 2.3e-08 34.4 0.0 5.3e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain TBPIP PF07106.11 001251988.1_39724001_1 - 0.0032 17.1 11.4 0.0032 17.1 11.4 3.2 1 1 2 3 3 3 2 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) HAP1_N PF04849.11 001251988.1_39724001_1 - 0.0055 15.8 19.2 0.0055 15.8 19.2 2.3 1 1 1 2 2 1 1 HAP1 N-terminal conserved region Reo_sigmaC PF04582.10 001251988.1_39724001_1 - 0.17 11.1 3.0 3.7 6.7 0.1 2.7 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Fib_alpha PF08702.8 001251988.1_39724001_1 - 0.54 10.3 27.2 0.92 9.6 2.5 4.0 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DIT1_PvcA PF05141.10 001251988.1_39724001_1 - 0.77 9.0 6.2 1.4 8.2 6.2 1.5 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein Flagellin_N PF00669.18 001251988.1_39724001_1 - 1.1 9.3 10.5 0.49 10.4 0.9 2.6 3 0 0 3 3 3 0 Bacterial flagellin N-terminal helical region DUF4407 PF14362.4 001251988.1_39724001_1 - 2.1 7.5 23.2 1.5 8.0 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) YscO PF07321.10 001251988.1_39724001_1 - 4 7.3 37.7 6.3 6.6 24.9 2.9 1 1 2 3 3 3 0 Type III secretion protein YscO DUF4162 PF13732.4 001251988.1_39724001_1 - 5 7.8 14.4 2.1 9.0 2.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) Tropomyosin PF00261.18 001251988.1_39724001_1 - 5.2 6.2 36.1 6.6 5.9 7.5 2.1 1 1 1 2 2 2 0 Tropomyosin HisKA_3 PF07730.11 001251988.1_39724001_1 - 8.3 6.9 7.5 14 6.1 0.8 2.8 2 0 0 2 2 2 0 Histidine kinase AAA PF00004.27 027182.2_32925001_1 - 1.7e-30 106.0 0.0 2.6e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 027182.2_32925001_1 - 1.5e-06 28.4 0.2 8.2e-06 26.0 0.2 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 027182.2_32925001_1 - 7.1e-06 26.4 0.0 1.4e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.4 027182.2_32925001_1 - 1.1e-05 25.8 0.0 3.9e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.4 027182.2_32925001_1 - 0.00013 21.8 0.0 0.00025 21.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 027182.2_32925001_1 - 0.00015 21.8 0.0 0.00031 20.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.4 027182.2_32925001_1 - 0.00048 19.6 0.2 0.25 10.8 0.0 2.2 2 0 0 2 2 2 2 AAA domain Cytidylate_kin PF02224.16 027182.2_32925001_1 - 0.0016 18.1 0.0 0.0034 17.0 0.0 1.5 1 0 0 1 1 1 1 Cytidylate kinase AAA_5 PF07728.12 027182.2_32925001_1 - 0.0032 17.4 0.0 0.0065 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) TsaE PF02367.15 027182.2_32925001_1 - 0.0035 17.2 0.0 0.0087 15.9 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.15 027182.2_32925001_1 - 0.0036 17.0 0.0 0.011 15.4 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein RuvB_N PF05496.10 027182.2_32925001_1 - 0.0043 16.2 0.0 0.0081 15.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus RNA_helicase PF00910.20 027182.2_32925001_1 - 0.0045 17.2 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 RNA helicase ATPase_2 PF01637.16 027182.2_32925001_1 - 0.0065 16.3 0.7 2.9 7.6 0.5 2.3 1 1 1 2 2 2 2 ATPase domain predominantly from Archaea AAA_30 PF13604.4 027182.2_32925001_1 - 0.0071 15.9 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.4 027182.2_32925001_1 - 0.0088 15.7 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.4 027182.2_32925001_1 - 0.009 16.1 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.10 027182.2_32925001_1 - 0.011 15.5 0.1 0.029 14.2 0.1 1.8 1 1 0 1 1 1 0 NACHT domain DUF815 PF05673.11 027182.2_32925001_1 - 0.014 14.5 0.1 0.049 12.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_24 PF13479.4 027182.2_32925001_1 - 0.014 15.0 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.16 027182.2_32925001_1 - 0.016 14.8 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TIP49 PF06068.11 027182.2_32925001_1 - 0.017 14.0 0.0 0.038 12.8 0.0 1.5 2 0 0 2 2 2 0 TIP49 C-terminus ABC_tran PF00005.25 027182.2_32925001_1 - 0.02 15.3 0.0 0.035 14.5 0.0 1.4 1 0 0 1 1 1 0 ABC transporter KAP_NTPase PF07693.12 027182.2_32925001_1 - 0.021 13.9 0.4 3.8 6.5 0.2 2.2 1 1 0 2 2 2 0 KAP family P-loop domain PduV-EutP PF10662.7 027182.2_32925001_1 - 0.026 14.1 0.0 0.062 12.9 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ATPase PF06745.11 027182.2_32925001_1 - 0.036 13.3 0.3 1.2 8.3 0.0 2.3 1 1 1 2 2 2 0 KaiC AAA_2 PF07724.12 027182.2_32925001_1 - 0.043 13.8 0.0 0.077 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_17 PF13207.4 027182.2_32925001_1 - 0.053 13.8 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.19 027182.2_32925001_1 - 0.057 12.7 0.0 0.24 10.6 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PhoH PF02562.14 027182.2_32925001_1 - 0.08 12.3 0.0 0.28 10.5 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_19 PF13245.4 027182.2_32925001_1 - 0.11 12.7 0.1 0.34 11.1 0.0 1.8 2 0 0 2 2 1 0 AAA domain NR_Repeat PF14046.4 007430.5_32924001_3 - 1.2e-92 303.8 28.3 1e-26 92.7 1.9 4.6 4 0 0 4 4 4 4 Nuclear receptor repeat Hormone_recep PF00104.28 007430.5_32924001_3 - 8.9e-16 58.0 0.6 2.1e-15 56.8 0.6 1.5 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor ANAPC4_WD40 PF12894.5 001280101.1_39725001_3 - 6.4e-17 61.5 0.2 0.0016 18.6 0.0 6.9 2 2 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 001280101.1_39725001_3 - 2.6e-15 56.4 12.2 0.13 13.0 0.0 9.9 11 0 0 11 11 11 4 WD domain, G-beta repeat Ge1_WD40 PF16529.3 001280101.1_39725001_3 - 9e-07 28.0 0.1 0.1 11.4 0.0 5.4 2 2 3 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.6 001280101.1_39725001_3 - 3.9e-05 22.1 0.1 0.0068 14.6 0.0 3.8 4 1 1 5 5 5 1 WD repeat-containing and planar cell polarity effector protein Fritz PQQ_2 PF13360.4 001280101.1_39725001_3 - 0.0052 16.3 1.0 0.033 13.6 0.3 2.4 2 1 0 2 2 2 1 PQQ-like domain Nucleoporin_N PF08801.9 001280101.1_39725001_3 - 0.015 14.0 0.1 1.4 7.5 0.0 3.3 4 0 0 4 4 4 0 Nup133 N terminal like WD40_like PF17005.3 001280101.1_39725001_3 - 0.022 14.0 0.0 3.1 6.9 0.1 2.7 1 1 1 2 2 2 0 WD40-like domain CPSF_A PF03178.13 001280101.1_39725001_3 - 0.072 12.2 0.0 0.28 10.3 0.0 1.9 2 0 0 2 2 2 0 CPSF A subunit region PD40 PF07676.10 001280101.1_39725001_3 - 0.12 12.3 0.0 21 5.0 0.0 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat RLL PF10036.7 001246406.1_39723001_1 - 1.8e-90 303.1 1.1 2.1e-90 302.9 1.1 1.0 1 0 0 1 1 1 1 Putative carnitine deficiency-associated protein Cactin_mid PF10312.7 001246406.1_39723001_1 - 0.0076 15.9 0.5 0.011 15.3 0.5 1.2 1 0 0 1 1 1 1 Conserved mid region of cactin PSGP PF07276.9 001246406.1_39723001_2 - 2.6 8.5 6.2 5.3 7.5 6.2 1.5 1 0 0 1 1 1 0 Apopolysialoglycoprotein (PSGP) TNF PF00229.16 001166039.1_21022001_1 - 3.7e-33 114.0 2.2 5.3e-33 113.5 2.2 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family DUF1049 PF06305.9 001166039.1_21022001_1 - 0.035 13.8 0.1 0.059 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Lectin_N PF03954.12 001166039.1_21022001_1 - 0.039 13.6 0.0 0.071 12.7 0.0 1.4 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain PAP_PilO PF06864.10 001166039.1_21022001_1 - 0.51 9.1 0.0 0.51 9.1 0.0 1.6 1 1 1 2 2 2 0 Pilin accessory protein (PilO) DUF1640 PF07798.9 001283087.1_21023001_1 - 3.6e-55 186.6 13.7 5.1e-55 186.1 13.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) JAKMIP_CC3 PF16034.3 001283087.1_21023001_1 - 0.34 10.7 11.2 0.54 10.0 10.5 1.6 1 1 1 2 2 2 0 JAKMIP CC3 domain TNF PF00229.16 001081819.2_21022001_3 - 3.8e-39 133.4 0.0 5.4e-39 132.9 0.0 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Helicase_C PF00271.29 105047.1_32928120_1 - 1.4e-12 47.8 0.0 2.4e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.4 105047.1_32928120_1 - 9.2e-07 28.5 16.5 2.8e-06 26.9 16.5 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 105047.1_32928120_1 - 9.8e-07 28.4 12.7 9.8e-07 28.4 12.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 105047.1_32928120_1 - 1.5e-05 24.6 16.5 5.4e-05 22.9 16.5 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 105047.1_32928120_1 - 3.7e-05 23.8 15.7 3.7e-05 23.8 15.7 2.6 3 0 0 3 3 1 1 Ring finger domain zf-RING_UBOX PF13445.4 105047.1_32928120_1 - 8e-05 22.4 13.9 8e-05 22.4 13.9 2.0 2 0 0 2 2 1 1 RING-type zinc-finger Prok-RING_4 PF14447.4 105047.1_32928120_1 - 0.00079 19.1 14.3 0.002 17.8 14.3 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 105047.1_32928120_1 - 0.0017 18.1 14.7 0.0017 18.1 14.7 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.5 105047.1_32928120_1 - 0.0025 17.7 4.7 0.0057 16.6 4.7 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.4 105047.1_32928120_1 - 0.0032 17.5 15.3 0.0032 17.5 15.3 2.1 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.4 105047.1_32928120_1 - 0.72 9.6 6.9 1.6 8.5 6.9 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein SNF2_N PF00176.21 105047.1_32928120_2 - 9.9e-48 162.5 0.0 1.4e-47 162.0 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.9 105047.1_32928120_2 - 4.4e-20 71.3 0.0 8.5e-20 70.4 0.0 1.4 1 0 0 1 1 1 1 HIRAN domain ResIII PF04851.13 105047.1_32928120_2 - 0.002 18.0 0.0 2.2 8.2 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit PT PF04886.10 024577.3_26229001_1 - 0.00034 20.0 25.7 0.00097 18.5 25.7 1.8 1 0 0 1 1 1 1 PT repeat PT PF04886.10 024577.3_26229001_2 - 1.5e-07 30.7 15.6 1.5e-07 30.7 15.6 2.4 2 0 0 2 2 2 1 PT repeat PT PF04886.10 024577.3_26229001_3 - 6.8e-10 38.2 19.9 3.9e-08 32.6 22.0 2.2 2 0 0 2 2 2 1 PT repeat TPR_12 PF13424.4 024577.3_26229001_3 - 8.8e-07 29.0 42.6 0.00043 20.4 2.3 7.6 6 1 1 7 7 7 2 Tetratricopeptide repeat SH3_1 PF00018.26 024577.3_26229001_3 - 7.1e-06 25.4 0.0 1.7e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 024577.3_26229001_3 - 2.4e-05 23.8 0.0 0.089 12.4 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain TPR_1 PF00515.26 024577.3_26229001_3 - 0.00035 20.1 12.3 0.0014 18.2 0.0 5.0 6 0 0 6 6 6 2 Tetratricopeptide repeat SNAP PF14938.4 024577.3_26229001_3 - 0.00063 19.1 0.4 0.021 14.2 0.0 2.5 3 0 0 3 3 3 1 Soluble NSF attachment protein, SNAP SH3_9 PF14604.4 024577.3_26229001_3 - 0.0012 18.5 0.0 0.0033 17.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain TPR_8 PF13181.4 024577.3_26229001_3 - 0.0053 16.7 11.4 6.1 7.2 0.1 6.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.15 024577.3_26229001_3 - 0.037 14.0 0.0 0.037 14.0 0.0 6.4 7 0 0 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.5 024577.3_26229001_3 - 4 7.6 7.9 3.2 7.9 0.3 3.6 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 IL4 PF00727.16 201270.1_45721001_1 - 7.6e-41 138.6 0.2 1e-40 138.2 0.2 1.1 1 0 0 1 1 1 1 Interleukin 4 Peptidase_M14 PF00246.22 001035507.2_26225001_2 - 1e-11 45.1 0.0 4.3e-11 43.0 0.0 2.2 1 1 0 1 1 1 1 Zinc carboxypeptidase FBP_C PF16571.3 001035507.2_26225001_3 - 0.0049 16.3 0.0 0.008 15.6 0.0 1.3 1 0 0 1 1 1 1 FBP C-terminal treble-clef zinc-finger zf-C2H2 PF00096.24 181374.2_45723001_3 - 2.5e-12 46.4 32.8 9.4e-06 25.7 0.6 3.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 181374.2_45723001_3 - 7e-12 45.1 10.3 4.3e-07 30.0 0.8 4.5 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 181374.2_45723001_3 - 2.4e-06 27.7 26.6 0.0044 17.6 3.1 4.0 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 181374.2_45723001_3 - 0.00069 19.7 3.3 0.29 11.4 0.9 3.4 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.9 181374.2_45723001_3 - 0.0067 16.2 2.3 0.14 12.0 0.6 2.6 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger zf-C2H2_8 PF15909.3 181374.2_45723001_3 - 0.018 15.2 1.9 0.032 14.4 1.9 1.4 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-met PF12874.5 181374.2_45723001_3 - 0.041 14.2 8.7 0.59 10.5 2.5 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.3 181374.2_45723001_3 - 0.9 9.5 2.1 1.7 8.6 0.0 2.0 2 0 0 2 2 2 0 Aberrant zinc-finger zf-C2H2_6 PF13912.4 181374.2_45723001_3 - 3.2 7.7 13.5 3.2 7.7 2.4 3.2 3 1 0 3 3 3 0 C2H2-type zinc finger zf-BED PF02892.13 181374.2_45723001_3 - 5.3 7.1 11.7 1.7 8.6 3.1 3.0 1 1 1 3 3 3 0 BED zinc finger NUDIX_5 PF16705.3 001350674.1_26229001_1 - 6.9e-85 283.1 0.0 1e-84 282.5 0.0 1.3 1 0 0 1 1 1 1 NUDIX, or N-terminal NPxY motif-rich, region of KRIT FERM_M PF00373.16 001350674.1_26229001_1 - 2.6e-19 69.6 0.1 6.2e-19 68.4 0.1 1.7 1 0 0 1 1 1 1 FERM central domain Ank_2 PF12796.5 001350674.1_26229001_1 - 1.5e-15 57.4 0.0 2.3e-06 28.0 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001350674.1_26229001_1 - 9.6e-13 48.0 0.1 1.3e-08 34.8 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 001350674.1_26229001_1 - 1.8e-10 41.0 0.7 3.1e-07 30.7 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 001350674.1_26229001_1 - 5.4e-09 36.0 0.0 0.073 13.4 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 001350674.1_26229001_1 - 8.5e-05 22.5 0.1 0.23 12.0 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Neur_chan_LBD PF02931.21 001347707.1_26228001_1 - 7.1e-24 84.3 4.2 3.9e-23 81.9 4.2 1.9 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 001347707.1_26228001_3 - 8.1e-94 314.0 0.0 1.3e-93 313.3 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 001347707.1_26228001_3 - 9.6e-17 61.0 0.1 1.3e-16 60.6 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF2417 PF10329.7 001347707.1_26228001_3 - 2.2 7.5 9.2 2 7.6 7.7 1.6 2 0 0 2 2 2 0 Region of unknown function (DUF2417) ABC_membrane PF00664.21 133411.1_45729001_1 - 7.3e-81 271.7 34.0 5.1e-45 154.1 10.0 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 133411.1_45729001_1 - 1.6e-56 190.5 0.1 1.5e-30 106.3 0.1 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 133411.1_45729001_1 - 1.1e-12 47.8 0.7 0.0049 16.2 0.1 4.2 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.21 133411.1_45729001_1 - 2.9e-07 30.4 0.7 0.0025 17.8 0.2 2.8 2 1 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.4 133411.1_45729001_1 - 7.8e-07 29.5 0.4 0.024 14.9 0.1 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.4 133411.1_45729001_1 - 1.9e-06 27.3 0.3 0.07 12.7 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.4 133411.1_45729001_1 - 2.3e-06 27.5 0.2 0.17 11.5 0.1 3.8 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF258 PF03193.14 133411.1_45729001_1 - 1e-05 25.4 0.0 0.14 11.9 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Dynamin_N PF00350.21 133411.1_45729001_1 - 0.00074 19.5 3.8 0.091 12.7 0.2 2.7 2 1 0 2 2 2 2 Dynamin family AAA_22 PF13401.4 133411.1_45729001_1 - 0.0009 19.4 1.5 1.2 9.3 0.0 3.4 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.15 133411.1_45729001_1 - 0.0017 18.0 0.6 6.1 6.4 0.0 3.6 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_23 PF13476.4 133411.1_45729001_1 - 0.0025 18.2 0.1 0.69 10.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 133411.1_45729001_1 - 0.0064 16.1 0.8 2.4 7.7 0.1 2.9 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.18 133411.1_45729001_1 - 0.012 14.6 0.0 1.4 7.8 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein Zeta_toxin PF06414.10 133411.1_45729001_1 - 0.049 12.8 0.2 4.8 6.3 0.1 2.6 2 0 0 2 2 2 0 Zeta toxin AAA PF00004.27 133411.1_45729001_1 - 0.09 13.1 1.2 11 6.3 0.0 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.11 133411.1_45729001_1 - 0.12 11.3 0.2 4.1 6.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Roc PF08477.11 133411.1_45729001_1 - 0.14 12.3 0.1 7.9 6.6 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_27 PF13514.4 133411.1_45729001_1 - 0.15 11.5 0.1 1.7 8.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.15 133411.1_45729001_1 - 0.15 11.9 0.9 0.52 10.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF87 NB-ARC PF00931.20 133411.1_45729001_1 - 0.35 9.7 2.0 2.1 7.2 0.0 2.6 3 0 0 3 3 3 0 NB-ARC domain cobW PF02492.17 133411.1_45729001_1 - 0.35 10.3 4.5 3 7.2 0.1 2.9 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain PRTase_1 PF11202.6 133411.1_45729001_2 - 0.26 10.3 0.0 0.39 9.8 0.0 1.1 1 0 0 1 1 1 0 Phosphoribosyl transferase (PRTase) HLH PF00010.24 001146165.1_21022001_1 - 1.6e-17 63.0 0.3 2.8e-17 62.3 0.3 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF773 PF05600.10 001146165.1_21022001_1 - 0.018 13.7 0.3 0.022 13.4 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF773) RGM_N PF06535.10 001012080.1_45725001_3 - 6.3e-60 202.0 0.0 9.2e-60 201.5 0.0 1.2 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) N-terminus RGM_C PF06534.11 001012080.1_45725001_3 - 1e-56 191.0 0.0 1.6e-56 190.3 0.0 1.3 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus PID PF00640.21 001202446.1_32927001_1 - 1.2e-34 119.2 0.2 1.8e-34 118.6 0.2 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH3_9 PF14604.4 001202446.1_32927001_1 - 2.6e-14 52.6 0.2 1.1e-13 50.7 0.2 2.1 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001202446.1_32927001_1 - 2.7e-06 26.7 0.0 5.6e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001202446.1_32927001_1 - 0.0034 16.9 0.0 0.0087 15.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PID_2 PF14719.4 001202446.1_32927001_1 - 0.0046 16.7 0.0 0.0075 16.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Ras PF00071.20 022692.1_45722001_2 - 6.2e-63 211.1 0.3 7.1e-63 210.9 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 022692.1_45722001_2 - 2.2e-35 121.4 0.1 5e-35 120.2 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 022692.1_45722001_2 - 8.8e-13 48.0 0.0 1.1e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 022692.1_45722001_2 - 3.8e-05 23.0 0.1 5.1e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 022692.1_45722001_2 - 7e-05 22.8 0.0 0.00011 22.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 022692.1_45722001_2 - 0.00045 20.0 0.3 0.33 10.7 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 022692.1_45722001_2 - 0.0026 17.2 0.0 0.0059 16.0 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.4 022692.1_45722001_2 - 0.013 15.7 0.1 0.021 15.0 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain MCR_beta PF02241.16 022692.1_45722001_2 - 0.048 13.1 0.1 0.059 12.8 0.1 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain BrnT_toxin PF04365.11 022692.1_45722001_2 - 0.07 13.4 0.1 0.54 10.5 0.0 2.1 2 0 0 2 2 2 0 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system Integrin_alpha2 PF08441.10 001114380.1_26229001_3 - 5.2e-38 131.0 0.0 7.4e-38 130.5 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.26 001114380.1_26229001_3 - 7.1e-19 68.6 0.1 1.1e-18 68.0 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.21 001114380.1_26229001_3 - 2.5e-18 65.7 7.8 6.4e-08 32.5 0.4 4.0 4 0 0 4 4 4 3 FG-GAP repeat VCBS PF13517.4 001114380.1_26229001_3 - 1.6e-08 34.8 0.2 1.5e-05 25.3 0.1 2.8 2 0 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.18 001114380.1_26229001_3 - 0.00017 21.2 0.4 0.00042 20.0 0.4 1.7 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region FG-GAP_2 PF14312.4 001114380.1_26229001_3 - 0.00023 21.2 10.1 0.065 13.4 0.0 4.6 4 0 0 4 4 4 2 FG-GAP repeat VWA_2 PF13519.4 001114380.1_26229001_3 - 0.0054 17.2 0.1 0.019 15.5 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain tRNA-synt_1 PF00133.20 020117.10_26229001_1 - 3.2e-40 137.8 0.0 3.4e-27 94.8 0.0 2.4 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.9 020117.10_26229001_1 - 8.2e-18 64.2 0.1 1.4e-09 37.1 0.1 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.11 020117.10_26229001_1 - 1.2e-17 64.2 0.0 3.5e-17 62.6 0.0 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.17 020117.10_26229001_1 - 2.2e-06 27.1 0.0 4.3e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain FERM_N PF09379.8 181833.2_26229001_3 - 4.8e-11 42.3 0.6 7.8e-11 41.6 0.6 1.3 1 0 0 1 1 1 1 FERM N-terminal domain FERM_M PF00373.16 181833.2_26229001_3 - 6.7e-07 29.6 0.0 1.1e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 FERM central domain Ras PF00071.20 001130441.1_45723001_2 - 7.6e-58 194.5 0.1 9.2e-58 194.3 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001130441.1_45723001_2 - 5.1e-21 75.0 0.0 7.3e-21 74.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001130441.1_45723001_2 - 7e-09 35.3 0.0 9.4e-09 34.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001130441.1_45723001_2 - 1.1e-05 24.9 0.1 4.3e-05 23.0 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001130441.1_45723001_2 - 1.8e-05 24.6 0.0 0.097 12.4 0.0 2.3 2 1 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 001130441.1_45723001_2 - 0.00012 22.0 0.0 0.00017 21.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001130441.1_45723001_2 - 0.0032 16.9 0.0 0.016 14.7 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B G-alpha PF00503.18 001130441.1_45723001_2 - 0.083 11.9 0.0 2.2 7.2 0.0 2.0 1 1 1 2 2 2 0 G-protein alpha subunit ATP_bind_1 PF03029.15 001130441.1_45723001_2 - 0.13 11.9 0.3 2 8.0 0.0 2.0 1 1 0 2 2 2 0 Conserved hypothetical ATP binding protein A2M_comp PF07678.12 000064.3_26229001_1 - 2.1e-56 191.1 0.9 2.4e-55 187.6 0.2 2.4 2 1 0 2 2 2 1 A-macroglobulin complement component A2M_recep PF07677.12 000064.3_26229001_1 - 3.9e-30 104.3 0.3 2e-29 102.1 0.1 2.4 2 0 0 2 2 2 1 A-macroglobulin receptor A2M PF00207.20 000064.3_26229001_1 - 2.3e-29 101.0 0.1 7.7e-29 99.3 0.1 2.0 1 0 0 1 1 1 1 Alpha-2-macroglobulin family NTR PF01759.19 000064.3_26229001_1 - 1.6e-27 95.2 0.2 4.7e-27 93.8 0.2 1.9 1 0 0 1 1 1 1 UNC-6/NTR/C345C module A2M_N_2 PF07703.12 000064.3_26229001_1 - 1.2e-26 93.6 2.6 3.7e-24 85.5 0.0 4.3 4 0 0 4 4 4 1 Alpha-2-macroglobulin family N-terminal region A2M_N PF01835.17 000064.3_26229001_1 - 1e-17 64.2 1.3 4.5e-15 55.7 0.0 3.8 5 0 0 5 5 5 1 MG2 domain Thiol-ester_cl PF10569.7 000064.3_26229001_1 - 2e-13 49.7 0.1 4.7e-13 48.4 0.1 1.7 1 0 0 1 1 1 1 Alpha-macro-globulin thiol-ester bond-forming region ANATO PF01821.16 000064.3_26229001_1 - 3.6e-11 43.6 8.5 9.6e-11 42.2 8.5 1.8 1 0 0 1 1 1 1 Anaphylotoxin-like domain Folliculin PF11704.6 175491.4_32928001_3 - 4e-08 33.2 0.1 7.2e-08 32.4 0.1 1.4 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport C9orf72-like PF15019.4 175491.4_32928001_3 - 0.023 14.1 0.0 0.56 9.6 0.0 2.3 2 0 0 2 2 2 0 C9orf72-like protein family DUF4536 PF15055.4 025849.4_32922001_3 - 4.2e-19 68.4 1.1 4.2e-19 68.4 1.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4536) ERM PF00769.17 181829.2_26229001_3 - 3.6e-64 216.8 39.5 3.6e-64 216.8 39.5 2.8 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_C PF09380.8 181829.2_26229001_3 - 6e-24 84.1 0.0 1.5e-23 82.8 0.0 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.16 181829.2_26229001_3 - 1.8e-22 79.8 0.3 1.8e-22 79.8 0.3 2.7 2 1 0 2 2 2 1 FERM central domain FERM_N PF09379.8 181829.2_26229001_3 - 7.8e-12 44.8 0.7 7.8e-12 44.8 0.7 2.1 2 0 0 2 2 2 1 FERM N-terminal domain CUE PF02845.14 001109668.1_45728001_2 - 9e-14 50.7 0.1 1.7e-13 49.8 0.1 1.5 1 0 0 1 1 1 1 CUE domain C2 PF00168.28 001109668.1_45728001_2 - 3.8e-13 49.5 0.0 7e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain UBA PF00627.29 001109668.1_45728001_2 - 0.011 15.5 0.1 0.02 14.7 0.1 1.4 1 0 0 1 1 1 0 UBA/TS-N domain Bradykinin PF06753.10 001204183.1_26224001_1 - 0.64 9.7 3.3 1.8 8.2 3.3 1.8 1 0 0 1 1 1 0 Bradykinin Pkinase PF00069.23 001204183.1_26224001_2 - 3.5e-62 210.0 0.2 7.6e-62 208.9 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 001204183.1_26224001_2 - 4e-42 144.2 0.0 7e-42 143.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001204183.1_26224001_2 - 4.1e-05 22.9 0.0 7.9e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 001204183.1_26224001_2 - 0.047 13.5 0.1 0.047 13.5 0.1 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family DUF3552 PF12072.6 001204183.1_26224001_2 - 0.77 9.0 10.4 1.3 8.2 10.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Clathrin_lg_ch PF01086.15 001080384.2_32924001_3 - 2.6e-57 194.2 0.3 3.4e-57 193.9 0.3 1.1 1 0 0 1 1 1 1 Clathrin light chain CENP-Q PF13094.4 001080384.2_32924001_3 - 0.0016 18.5 5.8 0.0024 17.9 5.8 1.2 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit ORC3_N PF07034.9 001080384.2_32924001_3 - 1.6 7.6 4.0 2.4 7.0 4.0 1.1 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus IFRD PF05004.11 019242.1_45724001_2 - 2.4e-110 368.3 1.6 2.9e-110 368.0 1.6 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) IFRD_C PF04836.10 019242.1_45724001_2 - 8.2e-24 83.8 0.4 2.5e-23 82.3 0.4 1.9 1 0 0 1 1 1 1 Interferon-related protein conserved region PWWP PF00855.15 001258008.1_26225001_3 - 3.8e-17 62.4 3.1 4.9e-17 62.0 0.0 2.7 2 0 0 2 2 2 1 PWWP domain zf-CW PF07496.13 001258008.1_26225001_3 - 2.3e-13 49.8 5.9 2.3e-13 49.8 5.9 3.1 3 0 0 3 3 3 1 CW-type Zinc Finger CM2 PF03021.12 001258008.1_26225001_3 - 0.18 11.5 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 Influenza C virus M2 protein OAS1_C PF10421.7 001081757.1_21029001_2 - 4.8e-244 801.9 0.0 2.8e-82 274.6 0.0 3.2 3 0 0 3 3 3 3 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus NTP_transf_2 PF01909.21 001081757.1_21029001_2 - 1.7e-14 53.8 0.0 4.5e-09 36.4 0.0 3.4 3 0 0 3 3 3 3 Nucleotidyltransferase domain BEX PF04538.10 001309419.1_21023001_3 - 4.2e-30 104.8 8.4 6.5e-30 104.2 8.4 1.3 1 0 0 1 1 1 1 Brain expressed X-linked like family tRNA-synt_1b PF00579.23 001309323.1_21024001_2 - 1.6e-67 227.8 0.1 2.1e-67 227.4 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) NUC194 PF08163.10 001163858.1_21029001_1 - 3.8e-159 529.9 0.6 3.8e-159 529.9 0.6 1.9 2 0 0 2 2 2 1 NUC194 domain FAT PF02259.21 001163858.1_21029001_1 - 8.6e-78 261.8 6.9 8.6e-78 261.8 6.9 2.5 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.25 001163858.1_21029001_1 - 1.1e-65 221.8 0.1 1.1e-65 221.8 0.1 3.2 3 0 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.18 001163858.1_21029001_1 - 6.3e-14 51.4 0.2 1.5e-13 50.1 0.2 1.7 1 0 0 1 1 1 1 FATC domain RIX1 PF08167.10 001163858.1_21029001_1 - 0.019 14.6 0.0 0.24 11.0 0.0 3.1 1 1 0 1 1 1 0 rRNA processing/ribosome biogenesis TPR_2 PF07719.15 001163858.1_21029001_1 - 8.1 6.7 9.7 7.2 6.9 1.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat NDK PF00334.17 001204742.1_21022001_1 - 3.2e-56 188.9 0.0 3.7e-56 188.7 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Uteroglobin PF01099.15 001267800.1_21021001_1 - 2.8e-18 65.7 0.1 3.4e-18 65.5 0.1 1.1 1 0 0 1 1 1 1 Uteroglobin family NDK PF00334.17 001204743.1_21022001_3 - 2.7e-55 186.0 0.0 3.3e-55 185.6 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Myosin_head PF00063.19 001081758.1_21029001_1 - 1.4e-293 975.2 2.6 1.4e-293 975.2 2.6 2.5 3 0 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 001081758.1_21029001_1 - 8.5e-165 550.2 273.7 1e-164 549.9 273.7 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 001081758.1_21029001_1 - 4.2e-14 51.9 4.9 1.1e-13 50.5 4.9 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 001081758.1_21029001_1 - 3.2e-05 23.4 77.7 0.0088 15.3 4.6 9.1 1 1 8 10 10 10 7 Reovirus sigma C capsid protein IQ PF00612.25 001081758.1_21029001_1 - 0.0023 17.4 1.5 0.02 14.5 0.4 2.6 2 0 0 2 2 2 1 IQ calmodulin-binding motif AAA_22 PF13401.4 001081758.1_21029001_1 - 0.09 12.9 0.0 0.09 12.9 0.0 6.5 4 2 2 6 6 6 0 AAA domain Filament PF00038.19 001081758.1_21029001_1 - 0.36 10.2 234.3 0.11 11.9 61.3 8.1 1 1 5 6 6 6 0 Intermediate filament protein RAB3GAP2_C PF14656.4 001309159.1_21029001_1 - 5.7e-243 807.4 13.1 7.3e-243 807.1 13.1 1.1 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit C-terminus RAB3GAP2_N PF14655.4 001309159.1_21029001_1 - 1.4e-164 548.1 0.0 2.1e-164 547.5 0.0 1.2 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus MHC_II_beta PF00969.17 001317256.1_21023001_3 - 1.7e-36 124.0 0.7 2.6e-36 123.5 0.7 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001317256.1_21023001_3 - 3.2e-27 94.7 0.8 1.2e-26 92.9 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001317256.1_21023001_3 - 8.3e-07 29.4 0.1 3.2e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001317256.1_21023001_3 - 0.0011 18.9 0.4 0.0021 18.1 0.1 1.6 2 0 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 001317256.1_21023001_3 - 0.0015 18.4 0.1 0.0026 17.7 0.1 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain MHC_I PF00129.16 001317256.1_21023001_3 - 0.0066 15.9 0.1 0.011 15.2 0.1 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 RecQ_Zn_bind PF16124.3 001317256.1_21023001_3 - 0.16 12.5 0.0 0.29 11.7 0.0 1.3 1 0 0 1 1 1 0 RecQ zinc-binding Ion_trans PF00520.29 001317259.1_21027001_1 - 9.7e-25 87.1 12.4 1.4e-24 86.6 12.4 1.1 1 0 0 1 1 1 1 Ion transport protein KCNQ_channel PF03520.12 001317259.1_21027001_1 - 5.8e-24 84.8 1.7 8.2e-24 84.3 0.8 1.6 2 0 0 2 2 2 1 KCNQ voltage-gated potassium channel Ion_trans_2 PF07885.14 001317259.1_21027001_1 - 2.7e-11 43.1 6.7 2.7e-11 43.1 6.7 2.2 2 0 0 2 2 2 1 Ion channel DUF4613 PF15390.4 001317259.1_21027001_1 - 0.012 13.9 0.1 0.016 13.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) 2TM PF13239.4 001317259.1_21027001_1 - 3.6 7.8 6.4 1.3 9.3 2.4 2.2 2 0 0 2 2 2 0 2TM domain EF-hand_1 PF00036.30 001283082.1_21023001_3 - 6.7e-42 137.8 9.6 1.3e-09 36.8 0.4 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 001283082.1_21023001_3 - 2.5e-35 120.6 2.7 2.3e-18 66.3 0.7 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 001283082.1_21023001_3 - 3e-33 113.2 9.2 3.8e-14 52.1 0.4 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.4 001283082.1_21023001_3 - 9.2e-30 99.9 5.7 3.4e-09 35.8 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.4 001283082.1_21023001_3 - 2.9e-26 89.6 6.7 2.7e-06 26.5 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.4 001283082.1_21023001_3 - 1.3e-13 50.9 0.2 1e-07 32.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 001283082.1_21023001_3 - 5.8e-09 35.7 0.2 0.00024 20.9 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 001283082.1_21023001_3 - 4.7e-07 30.0 0.0 0.017 15.3 0.0 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.9 001283082.1_21023001_3 - 6e-05 23.7 0.0 0.0046 17.7 0.0 2.2 1 1 1 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.8 001283082.1_21023001_3 - 0.00011 22.1 0.6 0.00035 20.5 0.1 2.1 2 0 0 2 2 2 1 Ca2+ insensitive EF hand UPF0154 PF03672.11 001283082.1_21023001_3 - 0.00026 20.8 0.0 0.17 11.8 0.0 2.9 2 1 1 3 3 3 1 Uncharacterised protein family (UPF0154) DUF1103 PF06513.9 001283082.1_21023001_3 - 0.0064 16.0 1.4 0.0086 15.6 1.4 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) DUF4497 PF14924.4 001283082.1_21023001_3 - 0.0065 16.8 0.0 3.5 8.0 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4497) Caleosin PF05042.11 001283082.1_21023001_3 - 0.018 14.8 0.4 1.6 8.5 0.0 3.0 1 1 3 4 4 4 0 Caleosin related protein DUF3349 PF11829.6 001283082.1_21023001_3 - 0.026 15.2 0.3 7.8 7.2 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) TerB PF05099.11 001283082.1_21023001_3 - 0.052 13.4 0.5 4.5 7.1 0.0 2.3 1 1 1 2 2 2 0 Tellurite resistance protein TerB DUF2267 PF10025.7 001283082.1_21023001_3 - 0.056 13.6 0.0 0.15 12.2 0.0 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) GPHH PF16905.3 001283082.1_21023001_3 - 0.077 12.7 0.0 0.52 10.0 0.0 2.3 3 0 0 3 3 2 0 Voltage-dependent L-type calcium channel, IQ-associated SurA_N_2 PF13623.4 001283082.1_21023001_3 - 0.13 12.0 0.5 1.7 8.4 0.1 2.2 1 1 1 2 2 2 0 SurA N-terminal domain RNA_pol_Rpb4 PF03874.14 001283082.1_21023001_3 - 0.15 12.2 0.8 4.9 7.4 0.1 2.4 2 0 0 2 2 2 0 RNA polymerase Rpb4 Prok-RING_2 PF14445.4 001283082.1_21023001_3 - 0.62 10.1 3.1 0.32 11.1 0.8 1.6 2 0 0 2 2 1 0 Prokaryotic RING finger family 2 zf-CCCH_3 PF15663.3 001308280.1_21029001_1 - 1.4e-56 189.3 5.1 2.9e-56 188.3 5.1 1.5 1 0 0 1 1 1 1 Zinc-finger containing family DUF2477 PF10631.7 001308280.1_21029001_1 - 0.068 13.7 3.3 0.059 13.9 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2477) Pkinase_Tyr PF07714.15 001242447.1_21026001_1 - 1.3e-104 349.0 0.0 2e-104 348.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001242447.1_21026001_1 - 4.7e-40 137.5 0.0 2.5e-25 89.2 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 001242447.1_21026001_1 - 1.4e-31 108.7 1.2 2e-08 34.6 0.0 5.7 5 0 0 5 5 5 4 Immunoglobulin domain I-set PF07679.14 001242447.1_21026001_1 - 2e-21 75.7 0.0 0.00015 21.7 0.0 6.2 5 1 0 5 5 5 4 Immunoglobulin I-set domain ig PF00047.23 001242447.1_21026001_1 - 2.9e-21 75.3 6.9 8.4e-12 45.0 0.0 6.3 5 2 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 001242447.1_21026001_1 - 1.7e-16 60.2 1.3 0.0003 21.0 0.0 5.1 4 1 1 5 5 5 3 Immunoglobulin domain V-set PF07686.15 001242447.1_21026001_1 - 2.4e-05 24.3 9.6 2.2 8.3 0.0 6.8 5 5 1 6 6 6 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 001242447.1_21026001_1 - 0.00013 21.9 0.7 0.0013 18.6 0.4 2.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 001242447.1_21026001_1 - 0.00082 19.2 0.0 3 7.8 0.0 3.9 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain C1-set PF07654.13 001242447.1_21026001_1 - 0.017 15.5 5.5 2.2 8.7 0.0 4.6 5 1 0 5 5 5 0 Immunoglobulin C1-set domain RRM_1 PF00076.20 001163827.1_21028001_3 - 1.9e-10 40.2 0.1 0.00069 19.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.15 001163827.1_21028001_3 - 1.9e-09 37.5 0.3 4.7e-09 36.3 0.3 1.7 1 0 0 1 1 1 1 PWI domain Nup35_RRM_2 PF14605.4 001163827.1_21028001_3 - 4.6e-07 29.6 0.0 0.00029 20.6 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif zf-CCCH PF00642.22 001163827.1_21028001_3 - 0.0011 18.7 2.9 0.0033 17.1 2.9 1.8 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Cornichon PF03311.12 001309303.1_21023001_2 - 3.9e-48 162.7 10.0 6.3e-48 162.0 10.0 1.3 1 0 0 1 1 1 1 Cornichon protein CHCH PF06747.11 001257140.1_21022001_1 - 0.00038 20.4 7.7 0.00038 20.4 7.7 2.6 3 0 0 3 3 3 1 CHCH domain COX17 PF05051.11 001257140.1_21022001_1 - 0.01 16.1 2.4 0.019 15.1 2.4 1.5 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) OmpH PF03938.12 001257140.1_21022001_1 - 0.093 12.6 0.7 0.12 12.2 0.7 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) CX9C PF16860.3 001257140.1_21022001_1 - 3.1 7.8 10.7 0.49 10.3 1.8 3.1 2 1 1 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.8 001257140.1_21022001_1 - 3.5 7.6 12.1 2.2 8.2 2.8 3.0 2 1 1 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like Myosin_head PF00063.19 001081760.1_21029001_1 - 2.7e-285 947.8 5.0 2.7e-285 947.8 5.0 3.5 3 1 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 001081760.1_21029001_1 - 9.9e-165 550.0 268.7 1.2e-164 549.7 268.7 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 001081760.1_21029001_1 - 5e-14 51.7 1.5 1.4e-13 50.3 1.5 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 001081760.1_21029001_1 - 1.7e-06 27.6 68.6 0.017 14.4 1.6 9.1 1 1 9 11 11 11 9 Reovirus sigma C capsid protein TSNAXIP1_N PF15739.3 001081760.1_21029001_1 - 0.0024 18.1 7.9 0.0024 18.1 7.9 15.6 4 4 10 16 16 11 2 Translin-associated factor X-interacting N-terminus IQ PF00612.25 001081760.1_21029001_1 - 0.0071 15.9 3.9 0.014 15.0 1.1 2.7 2 0 0 2 2 2 1 IQ calmodulin-binding motif AAA_22 PF13401.4 001081760.1_21029001_1 - 0.11 12.7 0.1 0.11 12.7 0.1 5.8 4 2 2 6 6 6 0 AAA domain DUF1664 PF07889.10 001081760.1_21029001_1 - 0.33 10.8 156.2 0.055 13.3 7.9 14.2 1 1 13 15 15 15 0 Protein of unknown function (DUF1664) AAA_16 PF13191.4 001081760.1_21029001_1 - 0.52 10.5 0.0 0.52 10.5 0.0 6.5 3 2 0 3 3 1 0 AAA ATPase domain Filament PF00038.19 001081760.1_21029001_1 - 0.59 9.5 231.7 0.027 13.9 11.2 8.1 1 1 5 7 7 6 0 Intermediate filament protein ADIP PF11559.6 001081760.1_21029001_1 - 9.6 6.1 232.0 0.017 15.1 19.5 12.3 3 3 8 11 11 10 0 Afadin- and alpha -actinin-Binding MMADHC PF10229.7 001286855.1_21023001_3 - 5.5e-131 436.1 0.0 6.4e-131 435.9 0.0 1.0 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type D protein Cwf_Cwc_15 PF04889.10 001309292.1_21024001_2 - 6e-77 258.6 23.2 7.4e-77 258.3 23.2 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Porin_3 PF01459.20 001309310.1_21023001_3 - 7.9e-85 284.5 6.3 9.2e-85 284.2 6.3 1.0 1 0 0 1 1 1 1 Eukaryotic porin ABC_membrane PF00664.21 001081763.1_21029001_1 - 4.5e-98 328.1 23.4 8.3e-55 186.2 2.9 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001081763.1_21029001_1 - 4.7e-53 179.2 0.0 1e-29 103.7 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 001081763.1_21029001_1 - 3.8e-08 32.9 1.1 0.0035 16.7 0.0 3.9 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.21 001081763.1_21029001_1 - 9.4e-06 25.6 0.2 0.11 12.4 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.4 001081763.1_21029001_1 - 2.3e-05 24.7 0.1 0.0068 16.7 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain DUF258 PF03193.14 001081763.1_21029001_1 - 0.00016 21.5 0.3 0.06 13.1 0.1 2.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_25 PF13481.4 001081763.1_21029001_1 - 0.0002 20.8 1.0 0.0083 15.6 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.4 001081763.1_21029001_1 - 0.00067 19.8 1.5 0.56 10.3 0.0 3.3 2 1 0 2 2 2 1 AAA domain AAA_21 PF13304.4 001081763.1_21029001_1 - 0.00091 19.0 0.7 2.9 7.5 0.0 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001081763.1_21029001_1 - 0.0019 17.7 2.1 0.37 10.4 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain Zeta_toxin PF06414.10 001081763.1_21029001_1 - 0.0027 16.9 0.1 0.025 13.8 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin DUF87 PF01935.15 001081763.1_21029001_1 - 0.019 14.9 1.0 3.3 7.5 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_23 PF13476.4 001081763.1_21029001_1 - 0.034 14.5 0.2 14 6.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.20 001081763.1_21029001_1 - 0.05 12.5 1.2 1.3 7.8 0.0 2.9 3 0 0 3 3 3 0 NB-ARC domain Dynamin_N PF00350.21 001081763.1_21029001_1 - 0.052 13.5 2.6 0.2 11.5 0.2 2.4 2 0 0 2 2 2 0 Dynamin family Roc PF08477.11 001081763.1_21029001_1 - 0.1 12.7 0.3 20 5.3 0.0 3.0 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase ABC_ATPase PF09818.7 001081763.1_21029001_1 - 0.16 10.6 0.1 3 6.4 0.0 2.3 2 0 0 2 2 2 0 Predicted ATPase of the ABC class cobW PF02492.17 001081763.1_21029001_1 - 0.31 10.5 1.1 5.6 6.4 0.1 2.7 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain MHC_II_alpha PF00993.18 001283078.1_21022001_2 - 2.2e-16 59.2 0.1 3.5e-16 58.5 0.1 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set PF07654.13 001283078.1_21022001_2 - 1.4e-13 51.0 0.0 2.3e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain C1-set_C PF16196.3 001283078.1_21022001_2 - 1.4e-06 27.4 0.1 3.1e-06 26.4 0.1 1.6 1 0 0 1 1 1 1 C1-set C-terminal domain SKG6 PF08693.8 001283078.1_21022001_2 - 0.025 13.9 3.9 0.025 13.9 3.9 1.7 2 0 0 2 2 2 0 Transmembrane alpha-helix domain GSHPx PF00255.17 001166483.1_21023001_2 - 2.5e-36 123.4 0.3 3.9e-36 122.8 0.3 1.3 1 0 0 1 1 1 1 Glutathione peroxidase zf-HC5HC2H_2 PF13832.4 001163828.1_21027001_2 - 3.9e-37 126.6 4.3 3.9e-37 126.6 4.3 2.5 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.7 001163828.1_21027001_2 - 2.9e-34 118.6 0.7 2.9e-34 118.6 0.7 1.8 2 0 0 2 2 2 1 Enhancer of polycomb-like zf-HC5HC2H PF13771.4 001163828.1_21027001_2 - 2.3e-26 91.7 2.6 2.3e-26 91.7 2.6 3.5 3 0 0 3 3 3 1 PHD-like zinc-binding domain Bromodomain PF00439.23 001163828.1_21027001_2 - 1.2e-25 89.2 0.2 2.6e-25 88.2 0.2 1.6 1 0 0 1 1 1 1 Bromodomain PWWP PF00855.15 001163828.1_21027001_2 - 3.8e-14 52.8 0.1 2.4e-13 50.2 0.0 2.5 2 0 0 2 2 2 1 PWWP domain PHD_2 PF13831.4 001163828.1_21027001_2 - 1.7e-13 49.7 4.4 1.7e-13 49.7 4.4 2.8 2 1 1 3 3 3 1 PHD-finger PHD PF00628.27 001163828.1_21027001_2 - 6.6e-07 29.0 27.9 2.9e-06 27.0 13.5 2.9 2 0 0 2 2 2 2 PHD-finger Clathrin_H_link PF13838.4 001163828.1_21027001_2 - 0.12 12.2 0.1 0.43 10.4 0.1 1.9 2 0 0 2 2 2 0 Clathrin-H-link AAA_23 PF13476.4 001163828.1_21027001_2 - 2.4 8.5 5.2 1.5 9.1 0.5 2.5 3 0 0 3 3 3 0 AAA domain C1_2 PF03107.14 001163828.1_21027001_2 - 2.7 8.3 20.1 3.2 8.0 4.4 2.9 2 0 0 2 2 2 0 C1 domain Collagen PF01391.16 001081764.1_21029001_3 - 5.8e-173 560.7 739.0 2.5e-09 36.6 35.3 22.0 2 2 17 19 19 19 16 Collagen triple helix repeat (20 copies) COLFI PF01410.16 001081764.1_21029001_3 - 3.4e-113 376.5 0.1 4.2e-113 376.2 0.1 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Enolase_C PF00113.20 001267602.1_21023001_3 - 9e-154 510.9 0.0 1.1e-153 510.5 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.14 001267602.1_21023001_3 - 9e-60 200.4 0.0 1.6e-59 199.7 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.4 001267602.1_21023001_3 - 5.2e-07 29.4 0.0 9.7e-07 28.5 0.0 1.4 1 1 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.9 001267602.1_21023001_3 - 3e-05 23.2 0.4 6e-05 22.2 0.4 1.5 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus SLBP_RNA_bind PF15247.4 001267801.1_21022001_1 - 4.6e-30 103.4 7.1 6.5e-30 102.9 7.1 1.2 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain E1-E2_ATPase PF00122.18 001081765.1_21029001_1 - 3e-64 216.2 1.3 3e-64 216.2 1.3 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 001081765.1_21029001_1 - 2.4e-46 157.6 2.1 5.9e-46 156.3 2.1 1.7 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 001081765.1_21029001_1 - 4e-21 74.8 0.5 7.4e-21 73.9 0.5 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 001081765.1_21029001_1 - 1.3e-17 64.7 0.0 9.7e-17 61.8 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 001081765.1_21029001_1 - 9.2e-17 60.3 0.9 4.8e-16 58.0 0.1 2.5 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 001081765.1_21029001_1 - 2.2e-05 24.2 0.5 4.4e-05 23.2 0.5 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 001081765.1_21029001_1 - 0.00066 20.0 0.0 0.0026 18.0 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase AMH_N PF04709.10 001317263.1_21024001_1 - 1.8e-143 478.0 0.5 2.2e-143 477.7 0.5 1.1 1 0 0 1 1 1 1 Anti-Mullerian hormone, N terminal region TGF_beta PF00019.18 001317263.1_21024001_1 - 4.4e-16 59.5 0.3 6.3e-16 59.0 0.3 1.2 1 0 0 1 1 1 1 Transforming growth factor beta like domain DUF4713 PF15831.3 001305452.1_21022001_2 - 3.9e-22 78.3 6.1 6.6e-22 77.6 6.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4713) NO_synthase PF02898.13 001081769.1_21028001_1 - 6.9e-184 610.9 0.0 9.4e-184 610.4 0.0 1.2 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.18 001081769.1_21028001_1 - 1.4e-78 263.3 0.0 2.2e-78 262.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 001081769.1_21028001_1 - 8.9e-41 139.3 0.1 1.7e-40 138.4 0.1 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.19 001081769.1_21028001_1 - 3.8e-22 78.8 0.0 8.5e-22 77.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain EF-hand_1 PF00036.30 001309345.1_21027001_3 - 6e-24 81.6 13.9 1.3e-05 24.3 0.4 4.6 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.4 001309345.1_21027001_3 - 2.5e-23 82.2 2.2 8.4e-13 48.5 0.3 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 001309345.1_21027001_3 - 2.1e-18 64.8 8.3 0.00017 20.8 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.4 001309345.1_21027001_3 - 2.9e-18 64.0 7.5 0.00013 21.5 0.2 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.4 001309345.1_21027001_3 - 4.7e-15 55.0 8.0 0.0078 15.8 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001309345.1_21027001_3 - 2.6e-06 27.6 0.3 0.029 14.5 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 001309345.1_21027001_3 - 6.7e-05 22.6 2.9 0.05 13.4 0.1 3.0 2 2 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.4 001309345.1_21027001_3 - 0.06 13.5 0.1 0.71 10.1 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain Oest_recep PF02159.13 001081772.1_21028001_3 - 1.6e-64 216.4 4.9 1.6e-64 216.4 4.9 1.9 2 0 0 2 2 2 1 Oestrogen receptor Hormone_recep PF00104.28 001081772.1_21028001_3 - 4.9e-33 114.3 4.4 7.2e-33 113.8 4.4 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001081772.1_21028001_3 - 3.3e-31 107.4 13.9 6.2e-31 106.5 13.9 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) ESR1_C PF12743.5 001081772.1_21028001_3 - 4.8e-26 90.1 4.5 4.8e-26 90.1 4.5 2.1 2 0 0 2 2 2 1 Oestrogen-type nuclear receptor final C-terminal IL4Ra_N PF09238.8 001081774.2_21028001_1 - 1e-39 134.7 2.6 1.7e-39 133.9 2.6 1.4 1 0 0 1 1 1 1 Interleukin-4 receptor alpha chain, N-terminal Tissue_fac PF01108.15 001081774.2_21028001_1 - 0.002 17.8 2.2 0.0046 16.6 2.2 1.6 1 0 0 1 1 1 1 Tissue factor fn3 PF00041.19 001081774.2_21028001_1 - 0.01 16.1 1.3 0.02 15.1 1.3 1.5 1 0 0 1 1 1 1 Fibronectin type III domain LRR_8 PF13855.4 001081777.1_21026001_1 - 2.8e-33 113.3 26.1 1.3e-12 47.2 4.2 5.7 3 1 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 001081777.1_21026001_1 - 1.1e-19 69.9 30.8 5.9e-05 23.2 0.5 7.0 2 1 2 6 6 6 5 Leucine Rich repeats (2 copies) LRRNT PF01462.16 001081777.1_21026001_1 - 3.4e-08 32.8 2.5 3.4e-08 32.8 2.5 2.8 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 001081777.1_21026001_1 - 6.3e-08 32.2 3.2 0.029 13.7 0.0 3.9 1 1 3 4 4 4 2 Leucine-rich repeat LRR_6 PF13516.4 001081777.1_21026001_1 - 8.4e-06 25.3 23.6 3.3 7.9 0.1 8.7 8 0 0 8 8 8 3 Leucine Rich repeat LRR_5 PF13306.4 001081777.1_21026001_1 - 2.9e-05 23.9 0.1 0.081 12.8 0.0 2.7 2 1 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_1 PF00560.31 001081777.1_21026001_1 - 9.4e-05 22.2 25.5 1.1 9.9 0.2 9.3 6 2 3 9 9 9 2 Leucine Rich Repeat LRR_8 PF13855.4 001081780.2_21024001_3 - 1.5e-34 117.4 32.2 5.4e-11 42.0 5.1 7.0 6 2 0 6 6 6 5 Leucine rich repeat LRR_4 PF12799.5 001081780.2_21024001_3 - 1.4e-17 63.2 34.5 3.4e-06 27.1 0.1 6.8 1 1 7 9 9 9 8 Leucine Rich repeats (2 copies) LRRNT PF01462.16 001081780.2_21024001_3 - 2.9e-08 33.0 3.0 2.9e-08 33.0 3.0 2.3 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 001081780.2_21024001_3 - 4.7e-07 29.3 8.6 0.0098 15.3 0.8 3.6 1 1 3 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.4 001081780.2_21024001_3 - 3.6e-06 26.5 25.8 2.1 8.5 0.0 9.0 10 0 0 10 10 10 4 Leucine Rich repeat LRR_1 PF00560.31 001081780.2_21024001_3 - 1.5e-05 24.7 25.1 10 6.9 0.2 9.5 9 2 1 10 10 10 2 Leucine Rich Repeat LRR_3 PF07725.10 001081780.2_21024001_3 - 0.47 10.2 0.0 0.47 10.2 0.0 5.0 6 1 0 6 6 6 0 Leucine Rich Repeat HSP70 PF00012.18 001081778.2_21025001_3 - 6.1e-264 876.6 12.6 6.1e-264 876.6 12.6 1.5 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.11 001081778.2_21025001_3 - 1.8e-18 66.4 0.3 4.8e-17 61.6 0.1 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.4 001081778.2_21025001_3 - 0.00054 20.2 2.2 1.6 9.1 0.0 3.5 3 1 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.14 001081778.2_21025001_3 - 0.0021 17.7 0.0 0.0056 16.3 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.18 001081778.2_21025001_3 - 0.016 14.6 0.1 5.5 6.3 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DDR PF08841.8 001081778.2_21025001_3 - 0.042 12.7 0.4 0.2 10.5 0.3 2.0 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain HORMA PF02301.16 001081778.2_21025001_3 - 0.081 12.4 1.3 0.19 11.2 1.3 1.6 1 0 0 1 1 1 0 HORMA domain Radial_spoke_3 PF06098.9 001081778.2_21025001_3 - 0.14 11.3 8.3 0.27 10.3 8.3 1.4 1 0 0 1 1 1 0 Radial spoke protein 3 Lipase_GDSL_2 PF13472.4 001309348.1_21028001_1 - 3.7e-13 50.1 0.0 5.3e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.20 001309348.1_21028001_1 - 0.066 13.0 0.0 0.094 12.5 0.0 1.1 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase CH PF00307.29 001110134.1_21023001_2 - 5.9e-18 64.9 0.0 8.5e-18 64.4 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain Calponin PF00402.16 001110134.1_21023001_2 - 2.5e-12 46.0 5.1 2.5e-12 46.0 5.1 2.0 2 0 0 2 2 2 1 Calponin family repeat Biopterin_H PF00351.19 001081783.1_21023001_1 - 1.7e-175 582.7 0.1 2.1e-175 582.4 0.1 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.23 001081783.1_21023001_1 - 4.4e-05 23.0 0.1 0.00012 21.6 0.0 1.8 2 0 0 2 2 2 1 ACT domain MIEAP PF16026.3 001081783.1_21023001_1 - 0.062 13.3 0.3 0.11 12.5 0.3 1.4 1 0 0 1 1 1 0 Mitochondria-eating protein Spectrin PF00435.19 001309204.1_21029001_3 - 1.3e-148 485.1 805.1 5.1e-12 46.1 7.8 75.0 67 8 9 76 76 76 46 Spectrin repeat CH PF00307.29 001309204.1_21029001_3 - 7.5e-42 141.8 5.1 9.3e-20 70.7 0.0 5.8 5 0 0 5 5 5 2 Calponin homology (CH) domain KASH PF10541.7 001309204.1_21029001_3 - 9.5e-27 92.9 6.3 1.9e-26 91.9 6.3 1.6 1 0 0 1 1 1 1 Nuclear envelope localisation domain CAMSAP_CH PF11971.6 001309204.1_21029001_3 - 2.4e-06 27.1 0.0 0.056 13.2 0.0 3.5 2 0 0 2 2 2 2 CAMSAP CH domain Collagen_mid PF15984.3 001309204.1_21029001_3 - 0.068 12.8 0.7 0.55 9.8 0.1 2.8 2 0 0 2 2 2 0 Bacterial collagen, middle region Arc_PepC_II PF06847.9 001309204.1_21029001_3 - 0.55 10.7 2.6 61 4.1 0.2 6.5 2 0 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II TEX12 PF15219.4 001309204.1_21029001_3 - 3.5 7.9 6.2 77 3.6 0.1 5.8 4 0 0 4 4 4 0 Testis-expressed 12 Sushi PF00084.18 001081792.2_21027001_1 - 1.7e-73 242.9 86.9 1e-09 38.8 2.2 9.7 9 1 0 9 9 9 9 Sushi repeat (SCR repeat) Lectin_C PF00059.19 001081792.2_21027001_1 - 1.1e-21 77.5 7.1 3.1e-21 76.0 7.1 1.9 1 0 0 1 1 1 1 Lectin C-type domain EGF PF00008.25 001081792.2_21027001_1 - 0.00031 20.8 9.6 0.00031 20.8 9.6 4.5 3 0 0 3 3 3 1 EGF-like domain EGF_2 PF07974.11 001081792.2_21027001_1 - 0.00054 20.1 10.3 0.00054 20.1 10.3 3.8 3 0 0 3 3 3 1 EGF-like domain EGF_3 PF12947.5 001081792.2_21027001_1 - 0.0096 16.0 5.7 0.0096 16.0 5.7 5.2 5 0 0 5 5 5 1 EGF domain TUDOR PF00567.22 001163875.1_21027001_1 - 5.1e-25 87.7 0.0 1.5e-24 86.2 0.0 1.9 1 0 0 1 1 1 1 Tudor domain Pkinase PF00069.23 001163875.1_21027001_1 - 4.1e-18 65.6 0.3 1.6e-17 63.7 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 001163875.1_21027001_1 - 2.6e-09 36.6 0.0 6.7e-09 35.3 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Agenet PF05641.10 001163875.1_21027001_1 - 0.00063 20.0 0.1 0.0022 18.3 0.1 1.9 1 0 0 1 1 1 1 Agenet domain Helicase_C_2 PF13307.4 001163875.1_21027001_1 - 0.06 13.4 2.2 0.29 11.1 0.2 2.6 2 0 0 2 2 2 0 Helicase C-terminal domain Sin3_corepress PF08295.10 001163875.1_21027001_1 - 0.091 12.7 2.0 0.66 10.0 0.2 3.0 2 0 0 2 2 2 0 Sin3 family co-repressor CENP-Q PF13094.4 001163875.1_21027001_1 - 4.9 7.2 11.1 0.61 10.1 2.3 2.6 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4047 PF13256.4 001163875.1_21027001_1 - 6.7 6.8 16.8 0.13 12.3 1.2 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4047) Integrin_alpha2 PF08441.10 001081793.1_21027001_1 - 9.3e-114 380.7 0.0 1.1e-113 380.5 0.0 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 001081793.1_21027001_1 - 1.4e-19 69.7 15.7 3.4e-07 30.1 0.0 4.9 5 0 0 5 5 5 3 FG-GAP repeat VCBS PF13517.4 001081793.1_21027001_1 - 1.7e-10 41.2 4.2 2.1e-05 24.9 1.1 3.9 3 1 1 4 4 4 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.18 001081793.1_21027001_1 - 2.6e-05 23.7 0.2 6.2e-05 22.6 0.2 1.7 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region ASC PF00858.22 001195636.1_21025001_3 - 9.7e-93 311.2 0.0 1.2e-92 310.9 0.0 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Integrin_alpha2 PF08441.10 001309466.1_21029001_2 - 5.1e-58 197.0 5.5 8e-58 196.3 5.5 1.2 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.26 001309466.1_21029001_2 - 1.3e-42 145.9 0.9 2.4e-42 145.0 0.9 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.21 001309466.1_21029001_2 - 6.7e-19 67.6 8.8 1.8e-07 31.0 2.2 3.7 3 0 0 3 3 3 3 FG-GAP repeat VWA_2 PF13519.4 001309466.1_21029001_2 - 5.9e-14 52.5 0.0 1.4e-13 51.3 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VCBS PF13517.4 001309466.1_21029001_2 - 5.4e-07 30.0 8.5 0.018 15.5 0.1 3.9 4 0 0 4 4 4 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.4 001309466.1_21029001_2 - 5.2e-05 23.3 7.4 0.026 14.7 0.3 4.4 5 0 0 5 5 5 2 FG-GAP repeat LYRIC PF15686.3 001309466.1_21029001_2 - 0.003 17.1 0.6 0.0044 16.5 0.6 1.2 1 0 0 1 1 1 1 Lysine-rich CEACAM1 co-isolated protein family VWA_3 PF13768.4 001309466.1_21029001_2 - 0.0041 16.9 0.1 0.036 13.8 0.0 2.3 2 0 0 2 2 2 1 von Willebrand factor type A domain Integrin_alpha PF00357.18 001309466.1_21029001_2 - 0.025 14.4 3.7 0.058 13.3 3.7 1.7 1 0 0 1 1 1 0 Integrin alpha cytoplasmic region Cation_ATPase_N PF00690.24 001309466.1_21029001_2 - 0.36 10.4 2.4 0.75 9.4 2.4 1.5 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus FA_hydroxylase PF04116.11 001309338.1_21026001_2 - 7.5e-23 81.2 23.4 1.1e-22 80.7 18.6 2.4 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily CLCA PF08434.9 001081799.2_21026001_3 - 0 1204.6 0.0 0 1204.4 0.0 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel VWA_2 PF13519.4 001081799.2_21026001_3 - 7.8e-12 45.7 0.0 1.9e-11 44.4 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.26 001081799.2_21026001_3 - 6.1e-10 39.5 0.0 1.2e-09 38.5 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.12 001081799.2_21026001_3 - 0.0034 16.6 0.1 0.0094 15.2 0.1 1.6 1 1 0 1 1 1 1 VWA domain containing CoxE-like protein eIF3_N PF09440.8 001301291.1_21024001_3 - 8.7e-47 158.8 3.9 2.9e-46 157.1 3.9 1.9 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.25 001301291.1_21024001_3 - 6.4e-20 71.5 0.0 2.6e-19 69.5 0.0 2.1 1 0 0 1 1 1 1 PCI domain CSN8_PSD8_EIF3K PF10075.7 001301291.1_21024001_3 - 0.025 14.5 0.6 0.1 12.4 0.0 2.3 3 0 0 3 3 3 0 CSN8/PSMD8/EIF3K family SPESP1 PF15754.3 001301291.1_21024001_3 - 0.043 12.8 0.3 6.8 5.6 0.1 2.2 2 0 0 2 2 2 0 Sperm equatorial segment protein 1 HD_assoc PF13286.4 001301291.1_21024001_3 - 0.081 13.3 1.3 3 8.3 0.2 2.5 2 0 0 2 2 2 0 Phosphohydrolase-associated domain Integrin_beta PF00362.16 001081802.1_21026001_1 - 2e-112 374.8 0.1 2.8e-112 374.2 0.1 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 001081802.1_21026001_1 - 1.7e-22 78.7 1.3 4.2e-22 77.4 1.3 1.7 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 001081802.1_21026001_1 - 7.7e-22 77.5 10.7 7.7e-22 77.5 10.7 4.2 3 1 1 4 4 4 1 Integrin beta tail domain EGF_2 PF07974.11 001081802.1_21026001_1 - 7.8e-09 35.6 100.0 3.1e-05 24.1 15.0 5.8 6 0 0 6 6 6 4 EGF-like domain TRAP_beta PF05753.12 001309328.1_21023001_2 - 9.3e-70 233.5 0.0 1.3e-69 233.1 0.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) Peptidase_M10 PF00413.22 001081804.1_21026001_2 - 2.8e-65 218.9 0.0 4.1e-65 218.3 0.0 1.2 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 001081804.1_21026001_2 - 1.6e-43 146.2 4.8 5e-13 48.6 0.0 4.4 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 001081804.1_21026001_2 - 2.9e-13 49.7 0.0 4.7e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_3 PF13582.4 001081804.1_21026001_2 - 0.012 16.0 0.0 0.021 15.2 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001081804.1_21026001_2 - 0.014 14.9 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.22 001081804.1_21026001_2 - 0.042 13.3 0.0 6.2 6.3 0.0 2.2 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) DUF4953 PF16313.3 001081804.1_21026001_2 - 0.15 11.1 0.1 0.23 10.5 0.1 1.2 1 0 0 1 1 1 0 Met-zincin Reprolysin_5 PF13688.4 001081804.1_21026001_2 - 0.18 11.8 0.2 0.29 11.1 0.2 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 Insulin PF00049.16 001081809.1_21022001_1 - 1e-14 55.2 3.0 3.3e-14 53.5 3.0 1.8 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 001081809.1_21022001_1 - 2.7 7.9 12.4 1.2 9.1 1.2 2.7 3 0 0 3 3 3 0 Nematode insulin-related peptide beta type Thioredoxin PF00085.18 001081813.1_21022001_1 - 2.2e-32 111.0 1.6 3.1e-32 110.5 1.6 1.1 1 0 0 1 1 1 1 Thioredoxin DIM1 PF02966.14 001081813.1_21022001_1 - 1.7e-05 24.5 0.1 2.6e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_8 PF13905.4 001081813.1_21022001_1 - 3.8e-05 23.8 0.2 9.4e-05 22.5 0.2 1.7 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.4 001081813.1_21022001_1 - 0.00019 21.7 0.2 0.0014 18.9 0.2 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.4 001081813.1_21022001_1 - 0.00027 20.6 0.1 0.00036 20.2 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.4 001081813.1_21022001_1 - 0.00043 20.3 0.2 0.00071 19.6 0.2 1.4 1 0 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.11 001081813.1_21022001_1 - 0.00045 19.5 0.4 0.0006 19.1 0.4 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Glutaredoxin PF00462.22 001081813.1_21022001_1 - 0.004 17.2 0.7 0.0081 16.2 0.7 1.5 1 0 0 1 1 1 1 Glutaredoxin AhpC-TSA PF00578.19 001081813.1_21022001_1 - 0.0054 16.5 0.3 0.0079 16.0 0.3 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.8 001081813.1_21022001_1 - 0.082 12.4 0.1 0.11 12.0 0.1 1.2 1 0 0 1 1 1 0 Redoxin M-inducer_phosp PF06617.11 001145213.1_21023001_1 - 1e-59 201.9 12.9 4.5e-47 160.5 3.0 2.8 2 1 1 3 3 3 2 M-phase inducer phosphatase Rhodanese PF00581.18 001145213.1_21023001_1 - 2e-12 47.4 0.0 4.1e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Myc_target_1 PF15179.4 001145213.1_21023001_1 - 0.068 12.9 0.9 0.13 12.0 0.9 1.4 1 0 0 1 1 1 0 Myc target protein 1 HSP90 PF00183.16 001163955.1_21026001_1 - 7.6e-243 806.9 34.4 1e-242 806.5 34.4 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.24 001163955.1_21026001_1 - 3.7e-14 53.1 0.1 8.6e-14 51.9 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.4 001163955.1_21026001_1 - 4.3e-12 45.9 0.1 1.1e-11 44.6 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Zip PF02535.20 001163955.1_21026001_1 - 0.11 11.6 0.9 0.22 10.6 0.9 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.12 001163955.1_21026001_1 - 4 5.5 16.8 7.5 4.6 16.8 1.3 1 0 0 1 1 1 0 CDC45-like protein Ig_2 PF13895.4 001101655.2_21027001_1 - 2.5e-48 162.2 15.1 1.5e-16 60.3 0.1 6.3 6 0 0 6 6 6 6 Immunoglobulin domain Ig_3 PF13927.4 001101655.2_21027001_1 - 9.1e-32 109.4 11.0 1.6e-06 28.5 0.2 6.5 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 001101655.2_21027001_1 - 1.1e-14 54.2 17.0 0.00067 19.6 0.1 7.3 6 2 0 6 6 6 5 Immunoglobulin domain I-set PF07679.14 001101655.2_21027001_1 - 9e-08 32.0 14.4 0.057 13.3 0.2 6.9 5 3 0 5 5 5 3 Immunoglobulin I-set domain Izumo-Ig PF16706.3 001101655.2_21027001_1 - 4.4e-06 26.5 1.1 0.68 9.9 0.0 4.3 4 0 0 4 4 4 3 Izumo-like Immunoglobulin domain V-set PF07686.15 001101655.2_21027001_1 - 5.8e-06 26.3 11.2 2 8.5 0.2 7.1 6 2 0 6 6 6 2 Immunoglobulin V-set domain MAP17 PF15807.3 001101655.2_21027001_1 - 0.0049 16.9 0.0 0.016 15.3 0.0 1.9 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 C2-set_2 PF08205.10 001101655.2_21027001_1 - 0.011 15.6 6.2 0.74 9.8 0.2 4.3 4 1 1 5 5 5 0 CD80-like C2-set immunoglobulin domain C2-set PF05790.13 001101655.2_21027001_1 - 0.056 13.5 8.9 4.8 7.3 0.3 4.4 4 0 0 4 4 4 0 Immunoglobulin C2-set domain V-set_CD47 PF08204.9 001101655.2_21027001_1 - 0.32 10.8 4.2 2.6 7.9 0.0 3.9 4 0 0 4 4 4 0 CD47 immunoglobulin-like domain SNF PF00209.16 001081824.2_21025001_1 - 9.1e-226 750.4 37.4 1.1e-225 750.2 37.4 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family 5HT_transport_N PF03491.11 001081824.2_21025001_1 - 2.3e-25 88.4 2.0 2.3e-25 88.4 2.0 1.7 2 0 0 2 2 2 1 Serotonin (5-HT) neurotransmitter transporter, N-terminus DUF3384 PF11864.6 001081824.2_21025001_3 - 0.29 9.9 0.3 0.43 9.3 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3384) Pkinase PF00069.23 001309336.1_21025001_3 - 3.2e-67 226.5 0.0 4.2e-67 226.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001309336.1_21025001_3 - 4.2e-36 124.4 0.0 6.1e-36 123.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001309336.1_21025001_3 - 3.5e-06 26.4 0.0 5.9e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 001309336.1_21025001_3 - 0.09 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.12 001309336.1_21025001_3 - 0.11 11.7 0.0 0.23 10.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Calc_CGRP_IAPP PF00214.17 001163879.1_21023001_3 - 2.8e-29 101.8 0.0 4.1e-29 101.3 0.0 1.2 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family STAR_dimer PF16544.3 001081831.1_21023001_1 - 1.5e-27 94.8 0.1 2.6e-27 94.0 0.1 1.4 1 0 0 1 1 1 1 Homodimerisation region of STAR domain protein Quaking_NLS PF16551.3 001081831.1_21023001_1 - 8.6e-21 73.2 5.1 1.5e-20 72.4 5.1 1.4 1 0 0 1 1 1 1 Putative nuclear localisation signal of quaking KH_1 PF00013.27 001081831.1_21023001_1 - 3e-06 26.8 0.0 6.2e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 KH domain Phosducin PF02114.14 001081848.1_21023001_2 - 6.2e-132 438.3 1.8 7.6e-132 438.0 1.8 1.0 1 0 0 1 1 1 1 Phosducin zf-C4 PF00105.16 001081851.1_21025001_3 - 1.8e-31 108.3 11.5 3.9e-31 107.2 11.5 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001081851.1_21025001_3 - 1e-24 87.2 6.3 2.3e-24 86.0 6.3 1.5 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Biliv-reduc_cat PF09166.8 001309290.1_21023001_1 - 2.1e-53 179.3 0.1 3.3e-53 178.7 0.1 1.3 1 0 0 1 1 1 1 Biliverdin reductase, catalytic GFO_IDH_MocA PF01408.20 001309290.1_21023001_1 - 1e-19 71.4 0.0 2.1e-19 70.4 0.0 1.5 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Calc_CGRP_IAPP PF00214.17 001085424.1_21022001_1 - 1.4e-43 147.9 0.0 2e-43 147.5 0.0 1.2 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family Ifi-6-16 PF06140.11 001114146.1_21022001_2 - 5.3e-30 103.0 44.6 1e-28 98.9 26.1 2.6 1 1 2 3 3 3 2 Interferon-induced 6-16 family LBP_BPI_CETP PF01273.23 001081859.2_21022001_1 - 1.5e-27 96.1 0.4 2e-27 95.7 0.4 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain PAT1 PF09770.7 001081859.2_21022001_1 - 0.28 9.3 0.4 0.39 8.8 0.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GCSF PF16647.3 001081860.2_21023001_3 - 1.9e-78 261.4 3.1 2.6e-78 260.9 3.1 1.1 1 0 0 1 1 1 1 Granulocyte colony-stimulating factor GCSF PF16647.3 001309387.1_21024001_2 - 1.2e-86 287.9 3.7 1.7e-86 287.4 3.7 1.2 1 0 0 1 1 1 1 Granulocyte colony-stimulating factor ubiquitin PF00240.21 001081862.1_21023001_2 - 6.3e-138 448.6 15.7 8.1e-34 115.1 0.3 4.1 4 0 0 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.6 001081862.1_21023001_2 - 2e-66 219.6 16.9 6.6e-16 57.8 0.4 4.1 4 0 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 001081862.1_21023001_2 - 7.6e-25 87.0 7.3 4.6e-05 23.7 0.1 5.7 4 4 0 4 4 4 4 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 001081862.1_21023001_2 - 1.1e-13 51.1 2.6 0.1 12.6 0.1 4.9 4 3 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001081862.1_21023001_2 - 1.1e-11 45.1 0.2 0.81 10.2 0.0 4.2 1 1 1 4 4 4 4 DUF2407 ubiquitin-like domain Telomere_Sde2 PF13019.4 001081862.1_21023001_2 - 8.6e-08 32.0 0.0 3.6 7.3 0.0 4.1 1 1 3 4 4 4 4 Telomere stability and silencing DUF2870 PF11069.6 001081862.1_21023001_2 - 2e-06 27.9 0.0 17 5.7 0.0 4.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2870) RBD PF02196.13 001081862.1_21023001_2 - 2.8e-05 24.0 0.0 30 4.7 0.0 4.3 4 0 0 4 4 4 0 Raf-like Ras-binding domain PI3K_rbd PF00794.16 001081862.1_21023001_2 - 5.2e-05 23.2 2.2 8.7 6.4 0.1 4.4 4 0 0 4 4 4 0 PI3-kinase family, ras-binding domain FERM_f0 PF16511.3 001081862.1_21023001_2 - 0.00038 20.6 11.9 24 5.2 0.1 7.2 4 4 0 4 4 4 0 N-terminal or F0 domain of Talin-head FERM DUF969 PF06149.10 001081862.1_21023001_2 - 0.00052 19.4 0.0 21 4.3 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF969) DUF3861 PF12977.5 001081862.1_21023001_2 - 0.00072 19.5 1.7 52 4.0 0.0 4.2 4 0 0 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3861) FlgD_ig PF13860.4 001081862.1_21023001_2 - 0.00092 18.9 3.7 37 4.1 0.0 4.3 4 0 0 4 4 4 0 FlgD Ig-like domain TraK PF06586.9 001081862.1_21023001_2 - 0.0072 15.9 0.4 37 3.7 0.0 3.9 4 0 0 4 4 4 0 TraK protein ORF11CD3 PF10549.7 001081862.1_21023001_2 - 0.014 15.4 0.0 1.1e+02 2.9 0.0 4.4 4 0 0 4 4 4 0 ORF11CD3 domain GDYXXLXY PF14345.4 001081862.1_21023001_2 - 0.024 14.3 0.1 1.4e+02 2.1 0.0 4.0 4 0 0 4 4 4 0 GDYXXLXY protein CorA PF01544.16 001081862.1_21023001_2 - 0.042 13.0 0.8 73 2.4 0.0 3.8 4 0 0 4 4 4 0 CorA-like Mg2+ transporter protein ProRS-C_2 PF09181.8 001081862.1_21023001_2 - 0.1 12.6 3.1 1.6e+02 2.4 0.0 4.0 4 0 0 4 4 4 0 Prolyl-tRNA synthetase, C-terminal PI3K_p85B PF02192.14 001081862.1_21023001_2 - 7.6 6.2 6.9 2e+02 1.7 0.1 4.0 4 0 0 4 4 4 0 PI3-kinase family, p85-binding domain BC10 PF06726.10 001081862.1_21023001_3 - 0.0038 17.3 3.7 0.14 12.2 0.0 3.2 4 0 0 4 4 4 2 Bladder cancer-related protein BC10 IL8 PF00048.18 001081863.2_21022001_1 - 1.4e-22 79.4 1.5 2.3e-22 78.7 1.5 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like DUF3309 PF11752.6 001081863.2_21022001_2 - 0.0046 16.8 0.4 0.008 16.1 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3309) IL8 PF00048.18 001081864.2_21022001_2 - 2.5e-23 81.8 4.3 3.9e-23 81.2 4.3 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Serpin PF00079.18 001317249.1_21023001_1 - 7.8e-120 400.4 0.1 8.9e-120 400.2 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) IL8 PF00048.18 001081871.1_21022001_2 - 3.5e-24 84.6 6.0 5.4e-24 84.0 6.0 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.18 001163887.1_21021001_1 - 1e-24 86.3 1.7 1.3e-24 86.0 1.7 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like DUF4725 PF15854.3 001163887.1_21021001_1 - 0.0047 17.0 0.9 0.0059 16.7 0.7 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4725) Serpin PF00079.18 001114533.1_21023001_1 - 4.3e-120 401.3 0.1 5e-120 401.1 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) ERbeta_N PF12497.6 001309479.1_21025001_1 - 5.2e-51 171.1 9.4 9.6e-51 170.2 9.4 1.4 1 0 0 1 1 1 1 Estrogen receptor beta Hormone_recep PF00104.28 001309479.1_21025001_1 - 9.2e-35 120.0 0.5 1.7e-34 119.1 0.5 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001309479.1_21025001_1 - 1.4e-30 105.4 13.7 3.3e-30 104.2 13.7 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Trypsin PF00089.24 001081876.1_21022001_3 - 5.9e-65 219.0 0.0 6.7e-65 218.9 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001081876.1_21022001_3 - 5.9e-08 33.6 0.0 8.4e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain Pico_P2A PF00947.17 001081876.1_21022001_3 - 0.019 14.9 0.0 0.053 13.4 0.0 1.7 2 0 0 2 2 2 0 Picornavirus core protein 2A DSL PF01414.17 001081876.1_21022001_3 - 0.071 13.1 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Delta serrate ligand DUF1986 PF09342.9 001081876.1_21022001_3 - 0.081 13.2 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Peptidase_S29 PF02907.13 001081876.1_21022001_3 - 0.15 11.6 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease JAB PF01398.19 001309259.1_21023001_2 - 9.3e-24 83.5 0.6 9.3e-24 83.5 0.6 2.2 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease NHS PF15273.4 001309259.1_21023001_2 - 0.019 14.0 0.3 0.027 13.5 0.3 1.1 1 0 0 1 1 1 0 NHS-like Ribosomal_L5e PF17144.2 001081885.2_21022001_2 - 9.5e-95 314.9 0.7 9.5e-95 314.9 0.7 2.0 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.4 001081885.2_21022001_2 - 8.7e-40 135.4 12.6 8.7e-40 135.4 12.6 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region DUF3498 PF12004.6 001163972.1_21029001_3 - 2.4e-200 667.1 49.0 2.4e-200 667.1 49.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3498) RasGAP PF00616.17 001163972.1_21029001_3 - 3.9e-26 91.9 1.8 7.1e-17 61.7 0.8 3.4 2 2 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.28 001163972.1_21029001_3 - 4.4e-09 36.4 0.1 8.4e-09 35.5 0.1 1.5 1 0 0 1 1 1 1 C2 domain PH PF00169.27 001163972.1_21029001_3 - 0.00015 22.1 0.7 0.54 10.7 0.0 3.7 4 0 0 4 4 4 2 PH domain Bacillus_HBL PF05791.9 001163972.1_21029001_3 - 0.073 12.7 8.2 0.17 11.5 8.2 1.6 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) XLF PF09302.9 001163972.1_21029001_3 - 0.24 11.4 9.9 0.68 9.9 9.9 1.7 1 0 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component FAM76 PF16046.3 001163972.1_21029001_3 - 0.25 10.5 17.1 0.62 9.2 17.1 1.7 1 0 0 1 1 1 0 FAM76 protein FliD_C PF07195.10 001163972.1_21029001_3 - 5.4 6.2 12.1 7.1 5.8 2.6 2.6 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Exonuc_VII_L PF02601.13 001163972.1_21029001_3 - 7.8 5.8 15.8 16 4.8 15.8 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ribosomal_S10 PF00338.20 001309294.1_21022001_1 - 1.8e-16 60.0 0.1 3.2e-16 59.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Defensin_beta PF00711.17 001081887.1_21021001_1 - 2.5e-11 43.3 10.7 3.2e-11 42.9 10.7 1.1 1 0 0 1 1 1 1 Beta defensin hEGF PF12661.5 001081887.1_21021001_1 - 0.43 11.2 5.2 1.9 9.1 1.1 2.6 2 0 0 2 2 2 0 Human growth factor-like EGF DUF2205 PF10224.7 001309237.1_21029001_2 - 0.01 15.7 1.4 0.09 12.7 1.4 2.7 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) Ribosomal_L35Ae PF01247.16 001163880.1_21021001_1 - 1.4e-47 159.7 0.4 1.7e-47 159.4 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.16 001163880.1_21021001_1 - 0.021 14.9 0.0 1.5 9.0 0.0 2.2 2 0 0 2 2 2 0 RimM N-terminal domain DUF2080 PF09853.7 001163880.1_21021001_1 - 0.094 12.3 0.2 0.35 10.5 0.0 2.0 2 1 0 2 2 2 0 Putative transposon-encoded protein (DUF2080) Ribosomal_L30_N PF08079.10 001163864.1_21022001_1 - 2.3e-30 104.5 15.1 6e-30 103.2 15.1 1.8 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.18 001163864.1_21022001_1 - 6.9e-26 89.8 2.9 1.4e-25 88.8 1.5 2.2 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Phosphorylase PF00343.18 001145889.1_21026001_3 - 0 1143.4 0.0 0 1143.2 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase STAT_bind PF02864.13 001309512.1_21027001_1 - 8.3e-77 258.3 0.0 8.3e-77 258.3 0.0 2.0 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 001309512.1_21027001_1 - 6e-56 189.0 18.5 1.1e-55 188.1 18.5 1.5 1 0 0 1 1 1 1 STAT protein, all-alpha domain STAT_int PF02865.15 001309512.1_21027001_1 - 1.3e-37 128.8 7.9 1.3e-37 128.8 7.9 3.1 3 1 1 4 4 3 1 STAT protein, protein interaction domain SH2 PF00017.22 001309512.1_21027001_1 - 2.4e-13 49.8 0.0 6.1e-13 48.5 0.0 1.7 1 0 0 1 1 1 1 SH2 domain E2R135 PF11570.6 001309512.1_21027001_1 - 0.16 12.1 1.4 0.3 11.2 1.4 1.3 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 YojJ PF10372.7 001309512.1_21027001_1 - 0.57 10.2 7.1 1.6 8.7 0.4 2.7 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Syntaxin-6_N PF09177.9 001309512.1_21027001_1 - 0.59 10.6 7.1 0.15 12.5 0.6 2.8 2 1 1 3 3 3 0 Syntaxin 6, N-terminal Fib_alpha PF08702.8 001309512.1_21027001_1 - 1.5 8.9 12.4 0.86 9.7 7.5 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.10 001309512.1_21027001_1 - 1.5 8.7 5.0 1.6 8.6 3.5 1.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus RecG_N PF17190.2 001309512.1_21027001_1 - 3.3 8.4 10.2 2.8 8.6 0.2 3.7 3 1 0 3 3 3 0 RecG N-terminal helical domain DUF1664 PF07889.10 001309512.1_21027001_1 - 5.8 6.8 8.4 8.9 6.2 0.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Tropomyosin_1 PF12718.5 001309512.1_21027001_1 - 6.8 6.7 12.1 0.77 9.8 7.0 1.9 2 0 0 2 2 2 0 Tropomyosin like DUF342 PF03961.11 001309512.1_21027001_1 - 9.4 4.6 8.4 0.79 8.1 3.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF342) ODC_AZ PF02100.15 001130486.2_21022001_1 - 1.6e-20 73.1 0.0 2.5e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Pro_isomerase PF00160.19 001099761.1_21022001_1 - 4.5e-50 169.9 0.2 5.6e-50 169.6 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD S_100 PF01023.17 001163867.1_21022001_3 - 2.3e-16 59.1 0.9 3.7e-16 58.4 0.9 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 001163867.1_21022001_3 - 5.2e-06 26.7 0.1 7.9e-06 26.1 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001163867.1_21022001_3 - 0.00013 21.1 0.7 0.015 14.7 0.1 2.4 2 0 0 2 2 2 2 EF hand EFhand_Ca_insen PF08726.8 001163867.1_21022001_3 - 0.0021 18.0 0.1 0.0045 16.9 0.1 1.7 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_8 PF13833.4 001163867.1_21022001_3 - 0.0057 16.3 0.5 0.019 14.6 0.5 1.8 1 1 0 1 1 1 1 EF-hand domain pair PX PF00787.22 001100178.1_21022001_2 - 1.8e-14 53.6 0.2 2.6e-14 53.0 0.2 1.2 1 0 0 1 1 1 1 PX domain RWD PF05773.20 001309241.1_21022001_3 - 1.5e-26 92.8 1.8 1.5e-26 92.8 1.8 1.7 2 0 0 2 2 2 1 RWD domain DFRP_C PF16543.3 001309241.1_21022001_3 - 3.2e-06 27.4 6.8 3.2e-06 27.4 6.8 3.1 2 1 1 3 3 3 1 DRG Family Regulatory Proteins, Tma46 BUD22 PF09073.8 001309241.1_21022001_3 - 0.062 12.5 9.9 0.083 12.1 9.9 1.1 1 0 0 1 1 1 0 BUD22 Folliculin PF11704.6 001309241.1_21022001_3 - 0.094 12.4 0.9 0.14 11.9 0.9 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport PARP PF00644.18 001309241.1_21022001_3 - 0.12 11.8 0.6 0.22 11.0 0.1 1.6 2 0 0 2 2 2 0 Poly(ADP-ribose) polymerase catalytic domain SAA PF00277.16 001163892.1_21022001_1 - 2.5e-50 169.1 5.7 3e-50 168.8 5.7 1.1 1 0 0 1 1 1 1 Serum amyloid A protein p450 PF00067.20 001190938.1_21024001_1 - 1e-134 449.6 0.2 1.2e-134 449.5 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Trypsin PF00089.24 001081893.1_21022001_3 - 1.4e-60 204.8 0.0 1.6e-60 204.6 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001081893.1_21022001_3 - 9.4e-07 29.7 0.0 1.8e-06 28.8 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001081893.1_21022001_3 - 5.8e-06 26.5 0.1 5.3e-05 23.5 0.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1986) DUF316 PF03761.13 001081893.1_21022001_3 - 0.011 15.2 0.0 0.026 14.0 0.0 1.8 1 1 0 1 1 1 0 Chymotrypsin family Peptidase-S1 MHC_I_3 PF16497.3 001252308.1_21023001_1 - 1.5e-89 298.7 0.8 1.9e-89 298.2 0.8 1.2 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001252308.1_21023001_1 - 8.1e-11 42.1 0.0 1.5e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001252308.1_21023001_1 - 9.4e-07 28.4 0.0 1.5e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_3 PF16497.3 001163862.1_21023001_3 - 6e-72 241.2 0.0 7.7e-72 240.8 0.0 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001163862.1_21023001_3 - 1.8e-11 44.2 0.0 3.4e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001163862.1_21023001_3 - 1.7e-05 24.3 0.0 3.7e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 ig PF00047.23 001163862.1_21023001_3 - 0.025 14.6 0.0 0.043 13.8 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin domain Ig_3 PF13927.4 001163862.1_21023001_3 - 0.056 13.9 0.0 0.12 12.9 0.0 1.6 1 1 0 1 1 1 0 Immunoglobulin domain DUF4381 PF14316.4 001163862.1_21023001_3 - 0.23 11.5 2.2 4.2 7.5 1.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) UCH PF00443.27 001099759.1_21024001_1 - 1.4e-61 208.1 0.2 2.2e-61 207.5 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 001099759.1_21024001_1 - 1.2e-23 84.1 0.0 1.7e-22 80.3 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.17 001099759.1_21024001_1 - 3.4e-20 72.0 14.5 3.4e-20 72.0 14.5 2.9 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RVT PF13966.4 001099759.1_21024001_3 - 0.013 16.2 0.5 0.026 15.2 0.5 1.4 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase E1_DerP2_DerF2 PF02221.13 001081898.1_21022001_3 - 6.1e-15 55.7 0.0 7.2e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 ML domain Lamp PF01299.15 001099762.1_21023001_3 - 5.4e-78 262.6 1.5 7.8e-78 262.1 1.5 1.2 1 0 0 1 1 1 1 Lysosome-associated membrane glycoprotein (Lamp) Endomucin PF07010.10 001099762.1_21023001_3 - 0.15 11.9 20.5 1.9 8.3 0.2 2.1 2 0 0 2 2 2 0 Endomucin SPX PF03105.17 001099762.1_21023001_3 - 2.1 8.1 4.7 2.6 7.8 4.7 1.1 1 0 0 1 1 1 0 SPX domain HECT PF00632.23 001267604.1_21029001_1 - 8.9e-99 330.7 0.3 1.3e-98 330.2 0.3 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 001267604.1_21029001_1 - 2.3e-47 158.5 31.1 7.5e-13 48.0 4.2 4.6 4 0 0 4 4 4 4 WW domain TGFb_propeptide PF00688.16 001163970.1_21024001_3 - 4.6e-52 177.1 0.4 1.1e-51 175.9 0.1 1.6 2 0 0 2 2 2 1 TGF-beta propeptide TGF_beta PF00019.18 001163970.1_21024001_3 - 9.5e-34 116.3 0.5 2e-33 115.3 0.5 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain Furin-like_2 PF15913.3 001109682.1_21022001_1 - 1.6e-46 156.7 23.3 1.6e-46 156.7 23.3 1.9 2 0 0 2 2 2 1 Furin-like repeat, cysteine-rich TSP_1 PF00090.17 001109682.1_21022001_1 - 5.7e-06 26.3 7.9 5.7e-06 26.3 7.9 4.0 4 1 1 5 5 5 1 Thrombospondin type 1 domain RRM_1 PF00076.20 001163973.1_21022001_2 - 3.6e-18 65.0 0.0 6.1e-18 64.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 001163973.1_21022001_2 - 3.6e-06 26.8 0.0 1.3e-05 25.0 0.0 1.8 2 0 0 2 2 2 1 RNA binding motif RRM_5 PF13893.4 001163973.1_21022001_2 - 0.00034 20.1 0.0 0.00053 19.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SBP56 PF05694.9 001309514.1_21024001_2 - 2.5e-222 738.5 0.0 3e-222 738.2 0.0 1.0 1 0 0 1 1 1 1 56kDa selenium binding protein (SBP56) Lactonase PF10282.7 001309514.1_21024001_2 - 0.036 13.2 0.0 0.087 11.9 0.0 1.6 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller TatD_DNase PF01026.19 001301321.1_21023001_1 - 6.5e-54 182.9 0.0 7.7e-54 182.6 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase EF-hand_1 PF00036.30 001163952.1_21023001_2 - 1.7e-26 89.6 11.0 3.3e-07 29.2 0.7 5.3 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.4 001163952.1_21023001_2 - 2.1e-24 83.2 11.1 2.7e-07 29.8 0.6 5.4 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.4 001163952.1_21023001_2 - 5e-21 74.8 10.1 2.2e-09 37.5 2.7 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 001163952.1_21023001_2 - 1e-14 53.1 9.8 0.0035 16.7 0.0 4.9 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.4 001163952.1_21023001_2 - 8.7e-08 31.7 8.9 0.00069 19.2 0.5 4.0 4 0 0 4 4 4 3 EF-hand domain pair GPHH PF16905.3 001163952.1_21023001_2 - 0.00052 19.6 0.0 0.68 9.7 0.0 3.1 3 0 0 3 3 3 2 Voltage-dependent L-type calcium channel, IQ-associated SPARC_Ca_bdg PF10591.7 001163952.1_21023001_2 - 0.07 13.3 4.6 11 6.2 0.0 3.7 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.11 001163952.1_21023001_2 - 0.11 12.2 3.0 23 4.7 0.1 3.5 2 1 2 4 4 4 0 Caleosin related protein EF-hand_10 PF14788.4 001163952.1_21023001_2 - 1.4 8.7 8.8 4.4 7.1 0.2 3.9 3 1 1 4 4 4 0 EF hand RRM_1 PF00076.20 001163963.1_21025001_1 - 2.1e-13 49.8 0.0 1.3e-06 28.0 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.22 001163963.1_21025001_1 - 1.4e-07 32.1 0.0 4.1e-07 30.5 0.0 1.9 1 1 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.18 001163963.1_21025001_1 - 0.0032 17.1 0.0 0.011 15.4 0.0 1.9 1 1 0 1 1 1 1 3'-5' exonuclease RhoGEF PF00621.18 001195761.1_21023001_1 - 1.1e-29 103.8 0.0 1.4e-29 103.5 0.0 1.1 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 001195761.1_21023001_1 - 0.043 14.2 0.0 0.083 13.3 0.0 1.5 1 0 0 1 1 1 0 PH domain Troponin PF00992.18 001081904.1_21022001_1 - 2.3e-44 150.8 6.7 4.4e-44 149.9 6.7 1.5 1 0 0 1 1 1 1 Troponin Troponin-I_N PF11636.6 001081904.1_21022001_1 - 2.6e-12 46.3 9.6 4.5e-12 45.5 9.6 1.4 1 0 0 1 1 1 1 Troponin I residues 1-32 DUF919 PF06034.9 001081904.1_21022001_1 - 0.0071 16.0 0.2 0.0071 16.0 0.2 2.6 3 1 0 3 3 3 1 Nucleopolyhedrovirus protein of unknown function (DUF919) Tup_N PF08581.8 001081904.1_21022001_1 - 0.008 16.3 0.1 0.008 16.3 0.1 2.0 3 0 0 3 3 3 1 Tup N-terminal DUF3738 PF12543.6 001081904.1_21022001_1 - 0.093 12.7 1.9 0.4 10.7 0.3 2.6 2 2 0 2 2 2 0 Protein of unknown function (DUF3738) Aldo_ket_red PF00248.19 001081908.1_21024001_3 - 8.7e-54 182.5 0.0 1.3e-53 181.9 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family Ribosomal_S4e PF00900.18 001163950.1_21022001_1 - 1.9e-40 136.5 0.5 9.8e-40 134.2 0.5 2.0 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.3 001163950.1_21022001_1 - 1.3e-30 104.7 0.1 2.2e-30 103.9 0.1 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.10 001163950.1_21022001_1 - 3.7e-22 78.0 6.2 9.2e-22 76.7 6.2 1.7 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.23 001163950.1_21022001_1 - 5.8e-06 25.8 0.0 1.1e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.27 001163950.1_21022001_1 - 8.6e-06 25.4 0.2 2.8e-05 23.8 0.2 1.9 1 0 0 1 1 1 1 KOW motif WND PF07861.9 001163950.1_21022001_1 - 0.13 11.6 0.8 0.22 10.8 0.8 1.3 1 0 0 1 1 1 0 WisP family N-Terminal Region Pyr_redox_2 PF07992.12 001137609.1_21024001_1 - 1.2e-55 188.7 0.5 1.5e-55 188.4 0.5 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 001137609.1_21024001_1 - 1e-27 96.4 0.0 2.3e-27 95.3 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 001137609.1_21024001_1 - 8.1e-19 67.8 3.0 1.3e-15 57.6 0.2 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001137609.1_21024001_1 - 2.7e-16 59.5 0.6 4.5e-12 45.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 001137609.1_21024001_1 - 9e-07 28.2 0.3 3.6e-06 26.2 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.12 001137609.1_21024001_1 - 9.5e-05 21.1 0.4 0.00051 18.7 0.1 2.0 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.15 001137609.1_21024001_1 - 0.00012 21.2 0.4 0.00044 19.4 0.0 1.9 2 0 0 2 2 2 1 Thi4 family AlaDh_PNT_C PF01262.19 001137609.1_21024001_1 - 0.0003 20.0 0.0 0.043 13.0 0.0 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.5 001137609.1_21024001_1 - 0.0005 19.4 0.0 0.00082 18.7 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.20 001137609.1_21024001_1 - 0.0028 16.6 0.6 0.0052 15.8 0.6 1.6 1 1 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.4 001137609.1_21024001_1 - 0.0029 17.7 0.1 0.0029 17.7 0.1 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001137609.1_21024001_1 - 0.016 14.7 0.3 0.077 12.5 0.0 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.4 001137609.1_21024001_1 - 0.04 14.2 0.3 3.5 8.0 0.1 2.6 2 0 0 2 2 2 0 Putative NAD(P)-binding Lycopene_cycl PF05834.10 001137609.1_21024001_1 - 0.11 11.4 0.1 0.28 10.0 0.0 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_binding_3 PF01494.17 001137609.1_21024001_1 - 0.54 9.3 2.2 1.5 7.9 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain 3Beta_HSD PF01073.17 001308637.1_21024001_1 - 2.1e-107 358.2 0.0 2.6e-107 357.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 001308637.1_21024001_1 - 3.8e-22 78.8 0.0 5.3e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 001308637.1_21024001_1 - 4.5e-16 58.7 0.1 1.3e-15 57.1 0.1 1.6 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.3 001308637.1_21024001_1 - 1e-15 57.9 0.1 2.2e-15 56.8 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.13 001308637.1_21024001_1 - 5.6e-11 42.0 0.0 8.3e-11 41.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.4 001308637.1_21024001_1 - 6e-11 42.5 0.0 8.8e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.8 001308637.1_21024001_1 - 6.9e-07 29.2 0.0 1.2e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.11 001308637.1_21024001_1 - 3.7e-06 26.5 0.0 5.2e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.15 001308637.1_21024001_1 - 4e-06 26.0 0.0 5.5e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.17 001081911.1_21024001_2 - 2.3e-107 358.1 0.0 2.8e-107 357.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 001081911.1_21024001_2 - 4.2e-22 78.7 0.0 5.8e-22 78.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 001081911.1_21024001_2 - 4.9e-16 58.5 0.1 1.5e-15 56.9 0.1 1.6 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.3 001081911.1_21024001_2 - 1.1e-15 57.7 0.1 2.3e-15 56.7 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.13 001081911.1_21024001_2 - 6e-11 41.9 0.0 8.8e-11 41.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.4 001081911.1_21024001_2 - 6.5e-11 42.3 0.0 9.5e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.8 001081911.1_21024001_2 - 6.8e-07 29.2 0.0 1.3e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.11 001081911.1_21024001_2 - 3.9e-06 26.4 0.0 5.6e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.15 001081911.1_21024001_2 - 4.4e-06 25.9 0.0 6e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain ANF_receptor PF01094.26 001163978.1_21027001_2 - 7.8e-109 363.9 0.0 1e-108 363.4 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 001163978.1_21027001_2 - 2.1e-64 217.4 31.8 2.7e-64 217.0 29.9 1.9 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 001163978.1_21027001_2 - 4.9e-17 61.5 11.1 1.5e-16 60.0 11.1 1.9 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001163978.1_21027001_2 - 6.4e-12 45.7 0.0 9.5e-11 41.8 0.0 2.3 2 1 0 2 2 2 1 Periplasmic binding protein Ephrin_rec_like PF07699.11 001163978.1_21027001_2 - 0.0036 16.9 7.5 0.011 15.3 7.5 1.8 1 0 0 1 1 1 1 Putative ephrin-receptor like TFIIA PF03153.11 001163978.1_21027001_2 - 0.12 12.2 20.6 0.18 11.6 20.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit p450 PF00067.20 001317266.1_21023001_1 - 3.8e-146 487.3 0.0 4.3e-146 487.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_C14 PF00656.20 001309343.1_21024001_1 - 2.2e-48 165.2 0.0 2.8e-48 164.9 0.0 1.1 1 0 0 1 1 1 1 Caspase domain CARD PF00619.19 001309343.1_21024001_1 - 4.4e-07 29.7 0.0 1.2e-06 28.3 0.0 1.8 1 1 0 1 1 1 1 Caspase recruitment domain ATP-synt_C PF00137.19 001305445.1_21022001_2 - 2.4e-11 43.6 12.4 3.7e-11 43.1 12.4 1.3 1 0 0 1 1 1 1 ATP synthase subunit C EF-hand_7 PF13499.4 001159335.1_21021001_1 - 8.5e-14 51.7 3.8 1.7e-09 37.9 0.3 1.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 001159335.1_21021001_1 - 1.5e-12 46.0 3.0 3.9e-06 25.9 1.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.4 001159335.1_21021001_1 - 6.2e-11 41.2 2.1 0.00015 21.0 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 001159335.1_21021001_1 - 5.9e-10 38.1 1.8 2.1e-05 24.0 0.2 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.4 001159335.1_21021001_1 - 5.7e-07 29.1 0.9 0.00055 19.5 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair Skp1 PF01466.17 001159335.1_21021001_1 - 0.12 12.3 0.1 0.28 11.2 0.1 1.6 1 0 0 1 1 1 0 Skp1 family, dimerisation domain zf-Tim10_DDP PF02953.13 001309337.1_21022001_2 - 7.9e-15 54.1 1.1 2.2e-14 52.7 1.1 1.7 1 1 1 2 2 2 1 Tim10/DDP family zinc finger Parathyroid PF01279.15 001081917.1_21021001_1 - 3.1e-07 30.8 0.1 3.8e-07 30.6 0.1 1.3 1 0 0 1 1 1 1 Parathyroid hormone family ABC_ATPase PF09818.7 001081917.1_21021001_1 - 0.056 12.1 0.0 0.064 11.9 0.0 1.1 1 0 0 1 1 1 0 Predicted ATPase of the ABC class START PF01852.17 001309273.1_21022001_2 - 1.2e-24 86.8 0.0 1.6e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 START domain APOBEC_N PF08210.9 001163680.1_21022001_1 - 7.6e-41 139.8 0.2 9.1e-41 139.6 0.2 1.0 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001163680.1_21022001_1 - 8.4e-31 105.6 0.1 1.6e-30 104.7 0.1 1.5 1 0 0 1 1 1 1 APOBEC-like C-terminal domain HAD_2 PF13419.4 001163680.1_21022001_1 - 0.033 14.1 0.0 0.046 13.7 0.0 1.2 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase INCENP_N PF12178.6 001163680.1_21022001_1 - 0.088 12.6 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Chromosome passenger complex (CPC) protein INCENP N terminal DUF2553 PF10830.6 001309239.1_21029001_2 - 5.7 7.7 9.7 0.41 11.3 3.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2553) Calc_CGRP_IAPP PF00214.17 001081928.2_21022001_2 - 3.2e-44 150.0 0.1 4.1e-44 149.7 0.1 1.1 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family Sushi PF00084.18 001111342.1_21022001_1 - 8.4e-07 29.4 10.2 0.0044 17.5 1.2 2.5 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) BaffR-Tall_bind PF09256.8 001245977.1_21022001_1 - 2.9e-18 65.2 6.6 4.7e-18 64.5 6.6 1.3 1 0 0 1 1 1 1 BAFF-R, TALL-1 binding DUF4381 PF14316.4 001245977.1_21022001_1 - 0.044 13.9 0.7 0.068 13.3 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) TACI-CRD2 PF09305.8 001245977.1_21022001_1 - 0.6 10.1 2.5 1.8 8.5 2.4 1.8 1 1 1 2 2 2 0 TACI, cysteine-rich domain TCR_zetazeta PF11628.6 001309482.1_21022001_1 - 5.7e-16 57.8 3.6 1e-15 57.0 3.6 1.4 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 zeta chain ITAM PF02189.13 001309482.1_21022001_1 - 0.00027 21.1 0.1 0.00046 20.4 0.1 1.4 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif ubiquitin PF00240.21 001242453.1_21022001_3 - 1.4e-34 117.5 0.3 1.8e-34 117.1 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.15 001242453.1_21022001_3 - 9.5e-33 111.7 12.3 1.4e-32 111.1 12.3 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.6 001242453.1_21022001_3 - 9.3e-17 60.5 0.4 1.5e-16 59.8 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 001242453.1_21022001_3 - 1e-05 25.8 0.1 3.5e-05 24.0 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 001242453.1_21022001_3 - 0.0082 16.1 0.0 0.017 15.1 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001242453.1_21022001_3 - 0.081 13.4 0.1 0.097 13.1 0.1 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain V-set PF07686.15 001309202.1_21029001_3 - 1e-19 70.6 0.0 2e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001309202.1_21029001_3 - 0.00088 19.7 0.1 0.002 18.6 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001309202.1_21029001_3 - 0.0086 16.3 0.1 0.033 14.4 0.1 2.0 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001309202.1_21029001_3 - 0.043 13.7 0.0 0.079 12.9 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain ig PF00047.23 001309202.1_21029001_3 - 0.045 13.8 0.2 0.11 12.5 0.2 1.7 1 1 0 1 1 1 0 Immunoglobulin domain ANAPC4_WD40 PF12894.5 001309199.1_21029001_3 - 0.055 13.6 0.1 0.15 12.2 0.1 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain ribosomal_L24 PF17136.2 001309199.1_21029001_3 - 0.15 12.3 0.0 0.37 11.1 0.0 1.6 1 0 0 1 1 1 0 Ribosomal proteins 50S L24/mitochondrial 39S L24 Ribosomal_L7Ae PF01248.24 001309481.1_21022001_2 - 5e-30 103.0 1.8 6.6e-30 102.6 1.8 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family HAD PF12710.5 001309481.1_21022001_2 - 0.15 12.3 0.0 0.19 12.0 0.0 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase PrmA PF06325.11 001309201.1_21028001_2 - 4.3e-10 39.3 0.0 7.7e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.4 001309201.1_21028001_2 - 9.9e-10 38.9 0.0 3.2e-09 37.3 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_9 PF08003.9 001309201.1_21028001_2 - 1.9e-08 33.5 0.1 3e-08 32.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_31 PF13847.4 001309201.1_21028001_2 - 3.9e-07 29.8 0.1 6.9e-07 29.0 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001309201.1_21028001_2 - 4.8e-07 30.2 0.0 1e-06 29.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001309201.1_21028001_2 - 1.2e-05 25.2 0.0 2.4e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 001309201.1_21028001_2 - 0.00013 21.4 0.0 0.00024 20.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PRMT5 PF05185.14 001309201.1_21028001_2 - 0.00038 19.5 0.3 0.001 18.1 0.3 1.6 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Met_10 PF02475.14 001309201.1_21028001_2 - 0.0014 18.3 0.3 0.0037 16.9 0.1 1.7 2 0 0 2 2 2 1 Met-10+ like-protein zf-C2H2_2 PF12756.5 001309201.1_21028001_2 - 0.0043 17.2 0.8 0.0043 17.2 0.8 2.1 2 0 0 2 2 1 1 C2H2 type zinc-finger (2 copies) Methyltransf_18 PF12847.5 001309201.1_21028001_2 - 0.0045 16.8 0.0 0.0087 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001309201.1_21028001_2 - 0.0046 17.5 0.0 0.013 16.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain ATP-synt_B PF00430.16 001309201.1_21028001_2 - 0.24 11.4 1.2 0.38 10.7 1.2 1.2 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) DSPc PF00782.18 001309236.1_21029001_1 - 3e-33 114.3 0.0 7.1e-33 113.1 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DEK_C PF08766.9 001309236.1_21029001_1 - 1.9e-10 40.3 5.1 4.2e-10 39.3 5.1 1.6 1 0 0 1 1 1 1 DEK C terminal domain Y_phosphatase PF00102.25 001309236.1_21029001_1 - 0.095 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PMP22_Claudin PF00822.18 001081936.1_21022001_1 - 5e-50 169.5 15.7 5.9e-50 169.2 15.7 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001081936.1_21022001_1 - 9.7e-07 28.6 12.0 9.7e-07 28.6 12.0 2.1 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction DUF3169 PF11368.6 001081936.1_21022001_1 - 0.0018 17.7 3.7 0.0031 17.0 3.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3169) TMEM37 PF15108.4 001081936.1_21022001_1 - 0.0071 16.1 5.0 0.012 15.3 5.0 1.3 1 0 0 1 1 1 1 Voltage-dependent calcium channel gamma-like subunit protein family L_HMGIC_fpl PF10242.7 001081936.1_21022001_1 - 0.0095 16.0 13.8 0.019 15.0 13.8 1.7 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein DUF4064 PF13273.4 001081936.1_21022001_1 - 0.082 13.1 15.9 0.04 14.2 10.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) Serpin PF00079.18 001143954.1_21023001_1 - 5.6e-82 275.9 0.0 6.4e-82 275.7 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) ECH_1 PF00378.18 001309234.1_21024001_1 - 5.6e-35 120.7 0.0 7.8e-35 120.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 001309234.1_21024001_1 - 6.7e-19 68.4 0.1 9.7e-19 67.9 0.1 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase HLH PF00010.24 001105150.1_21022001_3 - 7.2e-18 64.2 0.2 1.3e-17 63.3 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Mito_fiss_reg PF05308.9 001105150.1_21022001_3 - 0.19 11.7 0.7 0.32 10.9 0.7 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.17 001105150.1_21022001_3 - 0.79 9.0 8.0 1.6 8.0 8.0 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Hormone_6 PF00236.16 001099763.1_21021001_1 - 7.3e-51 170.0 9.9 8.8e-51 169.7 9.9 1.1 1 0 0 1 1 1 1 Glycoprotein hormone PDGF PF00341.15 001099763.1_21021001_1 - 0.07 13.3 7.7 0.16 12.2 7.7 1.6 1 1 0 1 1 1 0 PDGF/VEGF domain DUF1218 PF06749.10 001099763.1_21021001_1 - 0.69 10.3 4.3 1.9 9.0 2.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1218) GSHPx PF00255.17 001166481.1_21022001_2 - 1.3e-39 134.0 0.2 1.7e-39 133.6 0.2 1.2 1 0 0 1 1 1 1 Glutathione peroxidase LysM PF01476.18 001166481.1_21022001_2 - 0.11 12.4 0.0 0.29 11.2 0.0 1.7 1 0 0 1 1 1 0 LysM domain Hormone_1 PF00103.18 001081948.1_21022001_1 - 3.4e-45 154.3 0.0 3.9e-45 154.1 0.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family Trypsin PF00089.24 001081892.1_21022001_1 - 1.8e-65 220.7 0.0 2.1e-65 220.5 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001081892.1_21022001_1 - 6e-08 33.6 0.0 9.2e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001081892.1_21022001_1 - 0.00011 22.4 0.2 0.00021 21.5 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) DM PF00751.16 001317265.1_21025001_3 - 4.1e-23 80.9 8.8 9.4e-23 79.7 8.8 1.6 1 0 0 1 1 1 1 DM DNA binding domain DMA PF03474.12 001317265.1_21025001_3 - 1.9e-16 59.2 0.1 3.3e-16 58.4 0.1 1.4 1 0 0 1 1 1 1 DMRTA motif Gelsolin PF00626.20 001081953.1_21025001_1 - 6.7e-107 349.4 0.0 7.4e-19 67.3 0.0 6.2 6 0 0 6 6 6 6 Gelsolin repeat APOBEC_N PF08210.9 001163682.1_21023001_1 - 1.6e-94 314.7 8.9 6.6e-47 159.6 0.4 2.0 2 0 0 2 2 2 2 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001163682.1_21023001_1 - 1.1e-57 191.7 1.0 6.8e-28 96.3 0.2 2.4 2 0 0 2 2 2 2 APOBEC-like C-terminal domain Hairy_orange PF07527.11 001163682.1_21023001_1 - 0.00015 21.8 0.2 0.57 10.3 0.0 2.5 2 0 0 2 2 2 2 Hairy Orange Toxin-deaminase PF14424.4 001163682.1_21023001_1 - 0.00017 21.6 0.0 0.66 9.9 0.0 2.2 2 0 0 2 2 2 2 The BURPS668_1122 family of deaminases dCMP_cyt_deam_1 PF00383.21 001163682.1_21023001_1 - 0.0007 19.3 0.1 0.38 10.5 0.0 2.3 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region Pox_A3L PF05288.9 001163682.1_21023001_1 - 0.0059 16.4 0.3 4.3 7.3 0.0 2.4 2 0 0 2 2 2 2 Poxvirus A3L Protein Tox-PL-2 PF15643.4 001163682.1_21023001_1 - 0.0064 16.5 0.1 3.8 7.6 0.0 2.5 2 0 0 2 2 2 2 Papain fold toxin 2 Sgf11 PF08209.9 001163682.1_21023001_1 - 0.0064 15.9 1.6 3 7.3 0.1 2.5 2 0 0 2 2 2 2 Sgf11 (transcriptional regulation protein) FGF PF00167.16 001163682.1_21023001_1 - 0.049 13.6 0.2 6.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Fibroblast growth factor DUF1885 PF08968.8 001163682.1_21023001_1 - 0.087 12.8 1.1 5.4 7.0 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1885) Eclosion PF04736.10 001163682.1_21023001_1 - 0.17 11.5 2.0 3 7.5 0.2 3.0 3 0 0 3 3 3 0 Eclosion hormone UPF0203 PF05254.10 001163682.1_21023001_1 - 0.45 10.7 6.6 7 6.9 1.5 2.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0203) DC_STAMP PF07782.11 001163682.1_21023001_2 - 0.16 11.6 0.0 0.23 11.1 0.0 1.1 1 0 0 1 1 1 0 DC-STAMP-like protein Polyoma_agno PF01736.14 001163682.1_21023001_3 - 0.0085 15.7 0.0 2.5 7.8 0.0 2.4 2 0 0 2 2 2 2 Polyomavirus agnoprotein DMA PF03474.12 001163682.1_21023001_3 - 0.63 9.5 3.9 10 5.7 0.2 2.3 2 0 0 2 2 2 0 DMRTA motif IL10 PF00726.15 001082490.1_21022001_1 - 2.4e-104 346.0 0.4 2.9e-104 345.7 0.4 1.0 1 0 0 1 1 1 1 Interleukin 10 IL22 PF14565.4 001082490.1_21022001_1 - 1.3e-07 31.8 0.2 1.7e-07 31.4 0.2 1.1 1 0 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor Pkinase PF00069.23 001143800.2_21025001_3 - 4e-56 190.2 0.1 7.2e-56 189.3 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001143800.2_21025001_3 - 4.7e-36 124.3 0.0 8.2e-36 123.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase dsrm PF00035.24 001143800.2_21025001_3 - 1.6e-25 89.4 2.8 3.2e-13 50.0 0.0 3.4 3 0 0 3 3 3 2 Double-stranded RNA binding motif Kdo PF06293.12 001143800.2_21025001_3 - 0.036 13.3 0.0 0.064 12.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DND1_DSRM PF14709.5 001143800.2_21025001_3 - 0.056 13.6 0.0 0.43 10.7 0.0 2.3 2 0 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 ABC1 PF03109.14 001143800.2_21025001_3 - 0.13 12.3 0.0 0.36 10.9 0.0 1.7 1 0 0 1 1 1 0 ABC1 family APOBEC_N PF08210.9 001163683.1_21022001_1 - 4.1e-46 157.0 0.8 4.6e-46 156.8 0.8 1.0 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001163683.1_21022001_1 - 4e-29 100.2 0.1 5.9e-29 99.7 0.1 1.3 1 0 0 1 1 1 1 APOBEC-like C-terminal domain Toxin-deaminase PF14424.4 001163683.1_21022001_1 - 0.094 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 The BURPS668_1122 family of deaminases Lipocalin PF00061.21 001082494.1_21022001_1 - 2.7e-31 108.6 0.0 3.3e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Defensin_propep PF00879.16 001166070.1_21021001_1 - 6.2e-21 74.3 2.2 8.2e-21 74.0 2.2 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166070.1_21021001_1 - 0.0032 17.9 10.9 0.0047 17.3 10.9 1.3 1 0 0 1 1 1 1 Mammalian defensin Defensin_propep PF00879.16 001166071.1_21021001_1 - 1.5e-22 79.5 2.9 2e-22 79.1 2.9 1.1 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166071.1_21021001_1 - 0.19 12.2 14.9 0.33 11.4 14.9 1.4 1 0 0 1 1 1 0 Mammalian defensin Defensin_propep PF00879.16 001166075.1_21021001_1 - 1.4e-18 66.8 1.9 2e-18 66.3 1.9 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166075.1_21021001_1 - 0.0071 16.7 14.7 0.0071 16.7 14.7 1.6 2 0 0 2 2 2 1 Mammalian defensin Defensin_beta PF00711.17 001166075.1_21021001_1 - 1.3 8.9 12.3 2.4 8.2 12.3 1.4 1 0 0 1 1 1 0 Beta defensin Defensin_propep PF00879.16 001166076.1_21021001_1 - 2.1e-19 69.5 3.0 3.1e-19 68.9 3.0 1.3 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166076.1_21021001_1 - 0.00012 22.4 17.9 0.00018 21.9 17.9 1.3 1 0 0 1 1 1 1 Mammalian defensin Defensin_propep PF00879.16 001166079.1_21021001_1 - 1.8e-22 79.3 1.8 2.4e-22 78.9 1.8 1.2 1 0 0 1 1 1 1 Defensin propeptide CDRN PF05174.10 001166079.1_21021001_2 - 0.1 12.2 0.2 0.25 11.0 0.0 1.8 2 0 0 2 2 2 0 Cysteine-rich D. radiodurans N terminus Defensin_propep PF00879.16 001166081.1_21021001_1 - 2.1e-23 82.3 1.6 2.7e-23 81.9 1.6 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_propep PF00879.16 001166085.1_21021001_1 - 2.7e-19 69.1 2.2 3.6e-19 68.7 2.2 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_beta PF00711.17 001166085.1_21021001_1 - 3.7 7.5 12.2 5.8 6.9 12.2 1.3 1 0 0 1 1 1 0 Beta defensin Defensin_propep PF00879.16 001166088.1_21021001_1 - 7.8e-24 83.6 6.1 1e-23 83.3 6.1 1.1 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166088.1_21021001_1 - 5e-08 33.2 11.5 1e-07 32.2 11.5 1.5 1 0 0 1 1 1 1 Mammalian defensin SWIM PF04434.15 001166088.1_21021001_1 - 0.028 14.0 0.1 0.074 12.6 0.1 1.7 1 0 0 1 1 1 0 SWIM zinc finger IL1 PF00340.17 001082512.1_21022001_1 - 1e-31 109.0 0.7 1.8e-31 108.2 0.7 1.3 1 0 0 1 1 1 1 Interleukin-1 / 18 Defensin_propep PF00879.16 001166090.1_21021001_1 - 1.6e-18 66.6 3.3 2.2e-18 66.2 3.3 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166090.1_21021001_2 - 0.0026 18.1 0.3 0.0045 17.4 0.3 1.4 1 0 0 1 1 1 1 Mammalian defensin TIMP PF00965.15 001082515.1_21022001_2 - 8e-59 198.4 0.9 9.3e-59 198.1 0.9 1.0 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase CX9C PF16860.3 001082515.1_21022001_3 - 0.027 14.3 0.0 0.078 12.9 0.0 1.8 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Sod_Fe_C PF02777.16 001082517.2_21022001_1 - 5e-39 132.4 0.0 9.3e-39 131.6 0.0 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.20 001082517.2_21022001_1 - 4e-31 107.2 3.4 5.9e-31 106.6 3.4 1.2 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain ig PF00047.23 001082518.2_21023001_2 - 3.3e-26 91.1 0.0 2.4e-09 37.1 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001082518.2_21023001_2 - 2.5e-20 72.5 0.0 6.9e-07 29.4 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 001082518.2_21023001_2 - 5.7e-18 65.2 0.0 0.00012 22.5 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001082518.2_21023001_2 - 2.4e-07 30.7 2.9 7 6.7 0.1 6.1 4 2 1 5 5 5 2 Immunoglobulin V-set domain SIT PF15330.4 001082518.2_21023001_2 - 0.0055 17.0 0.0 0.01 16.1 0.0 1.4 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT Lep_receptor_Ig PF06328.9 001082518.2_21023001_2 - 0.032 14.1 0.1 2.7 8.0 0.0 2.8 3 0 0 3 3 3 0 Ig-like C2-type domain DUF4721 PF15848.3 001082518.2_21023001_3 - 0.069 13.5 1.9 3.6 7.9 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4721) Ig_2 PF13895.4 001082524.1_21024001_1 - 5.8e-35 119.4 2.1 4.9e-12 45.9 0.1 4.5 4 0 0 4 4 4 4 Immunoglobulin domain Ig_3 PF13927.4 001082524.1_21024001_1 - 5.6e-25 87.6 3.4 7.9e-07 29.5 0.1 4.5 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 001082524.1_21024001_1 - 4.5e-21 74.7 6.1 1.3e-08 34.7 0.0 5.0 5 1 0 5 5 5 4 Immunoglobulin domain V-set PF07686.15 001082524.1_21024001_1 - 7.3e-06 26.0 3.6 1 9.4 0.0 5.4 3 2 2 5 5 5 1 Immunoglobulin V-set domain Ig_4 PF16680.3 001082524.1_21024001_1 - 0.067 13.4 3.2 6.7 7.0 0.1 4.6 5 1 0 5 5 5 0 T-cell surface glycoprotein CD3 delta chain Defensin_propep PF00879.16 001166098.1_21021001_1 - 1.1e-20 73.6 4.3 1.4e-20 73.3 4.3 1.1 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166098.1_21021001_1 - 0.00018 21.9 9.7 0.00018 21.9 9.7 1.8 2 0 0 2 2 2 1 Mammalian defensin Ig_2 PF13895.4 001083593.1_21023001_2 - 2e-15 56.7 0.0 1e-12 48.1 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001083593.1_21023001_2 - 3.2e-06 27.5 0.8 0.0032 17.9 0.3 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001083593.1_21023001_2 - 6.4e-06 26.1 0.0 0.019 15.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain adh_short PF00106.23 001083598.2_21022001_2 - 3.9e-38 130.8 0.0 5.1e-38 130.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001083598.2_21022001_2 - 1.4e-24 86.8 0.0 2e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001083598.2_21022001_2 - 2.5e-07 30.6 0.0 3.8e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.8 001083598.2_21022001_2 - 0.0098 15.2 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.6 001083598.2_21022001_2 - 0.17 11.6 0.0 1.3 8.7 0.0 2.2 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Globin PF00042.20 001085431.1_21021001_1 - 3.4e-29 101.5 0.1 4.7e-29 101.0 0.1 1.2 1 0 0 1 1 1 1 Globin Ank_2 PF12796.5 001089586.1_21028001_1 - 2.8e-44 149.5 7.9 2.6e-15 56.6 0.1 4.8 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001089586.1_21028001_1 - 2.8e-35 120.1 0.0 5.1e-09 36.4 0.0 6.5 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.4 001089586.1_21028001_1 - 3.9e-29 100.1 2.0 1.1e-09 38.2 0.1 5.6 2 1 4 6 6 6 6 Ankyrin repeats (many copies) Ribonuc_2-5A PF06479.10 001089586.1_21028001_1 - 3.1e-27 95.1 2.4 5.5e-27 94.3 2.4 1.4 1 0 0 1 1 1 1 Ribonuclease 2-5A Ank PF00023.28 001089586.1_21028001_1 - 1.2e-25 88.6 2.9 5.2e-05 23.4 0.0 9.0 9 0 0 9 9 9 7 Ankyrin repeat Ank_3 PF13606.4 001089586.1_21028001_1 - 1.1e-24 83.6 3.3 0.0075 16.6 0.0 9.7 9 0 0 9 9 9 5 Ankyrin repeat Pkinase PF00069.23 001089586.1_21028001_1 - 2.1e-14 53.4 0.0 1.1e-13 51.0 0.0 2.0 2 1 1 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.15 001089586.1_21028001_1 - 1.4e-07 31.0 0.0 2.8e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001089586.1_21028001_1 - 3.1e-05 23.3 0.0 5.6e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.18 001089586.1_21028001_1 - 0.016 14.7 0.1 0.029 13.8 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.20 001089586.1_21028001_1 - 0.061 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.4 001089586.1_21028001_1 - 0.077 12.2 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like FEZ PF07763.11 001097608.1_21022001_1 - 3.8e-40 138.0 9.1 5.2e-40 137.6 9.1 1.2 1 0 0 1 1 1 1 FEZ-like protein EURL PF06937.9 001097608.1_21022001_1 - 0.01 15.1 3.2 0.015 14.6 3.2 1.2 1 0 0 1 1 1 0 EURL protein DUF5102 PF17104.3 001097608.1_21022001_1 - 0.066 13.1 2.0 0.12 12.3 2.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5102) Ras PF00071.20 001309274.1_21023001_2 - 1.7e-57 193.4 0.0 2.2e-57 193.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001309274.1_21023001_2 - 1.7e-36 125.0 0.0 3.1e-36 124.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001309274.1_21023001_2 - 2.4e-14 53.0 0.0 3.4e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001309274.1_21023001_2 - 1.1e-08 34.6 0.0 1.4e-08 34.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001309274.1_21023001_2 - 5e-05 23.2 0.0 7.7e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001309274.1_21023001_2 - 0.00012 21.9 0.3 0.17 11.6 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001309274.1_21023001_2 - 0.00016 21.2 0.0 0.00079 18.9 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.15 001309274.1_21023001_2 - 0.00048 19.8 0.6 0.047 13.3 0.1 2.2 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.16 001309274.1_21023001_2 - 0.0046 16.4 0.2 0.018 14.4 0.2 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.8 001309274.1_21023001_2 - 0.0053 16.1 0.0 0.0077 15.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.27 001309274.1_21023001_2 - 0.0056 17.0 0.0 0.018 15.4 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.4 001309274.1_21023001_2 - 0.015 15.3 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.12 001309274.1_21023001_2 - 0.017 15.0 0.1 0.039 13.8 0.1 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.10 001309274.1_21023001_2 - 0.033 14.0 0.1 0.064 13.0 0.1 1.4 1 0 0 1 1 1 0 NACHT domain PduV-EutP PF10662.7 001309274.1_21023001_2 - 0.034 13.8 0.2 0.15 11.7 0.2 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.15 001309274.1_21023001_2 - 0.037 13.9 0.2 0.26 11.2 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.4 001309274.1_21023001_2 - 0.044 13.9 0.1 0.1 12.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 001309274.1_21023001_2 - 0.05 13.8 0.1 0.083 13.1 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain I-set PF07679.14 001145864.1_21025001_2 - 3.6e-35 119.8 0.1 4.8e-12 45.6 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 001145864.1_21025001_2 - 4.5e-35 120.0 1.0 6.2e-13 49.0 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001145864.1_21025001_2 - 1.4e-24 86.1 0.3 2.5e-09 37.2 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 001145864.1_21025001_2 - 2.3e-20 72.4 2.0 2.4e-07 30.7 0.0 4.6 4 1 0 4 4 4 4 Immunoglobulin domain V-set PF07686.15 001145864.1_21025001_2 - 2e-11 43.9 4.8 7.9e-06 25.9 0.2 5.1 3 3 1 4 4 4 3 Immunoglobulin V-set domain Izumo-Ig PF16706.3 001145864.1_21025001_2 - 2.4e-06 27.4 0.6 0.0029 17.5 0.1 3.7 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain Ig_5 PF16681.3 001145864.1_21025001_2 - 3.9e-06 27.1 0.0 0.036 14.3 0.0 3.5 3 1 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 001145864.1_21025001_2 - 5e-05 23.4 0.1 0.11 12.7 0.0 3.2 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.10 001145864.1_21025001_2 - 0.00018 21.4 0.1 0.076 13.0 0.0 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain V-set_CD47 PF08204.9 001145864.1_21025001_2 - 0.0058 16.5 0.0 1.1 9.1 0.0 2.5 2 0 0 2 2 2 1 CD47 immunoglobulin-like domain Adeno_E3_CR1 PF02440.13 001145864.1_21025001_2 - 0.023 14.3 1.8 2.2 8.0 0.0 3.5 3 1 0 3 3 3 0 Adenovirus E3 region protein CR1 Cu2_monoox_C PF03712.13 001081767.1_21029001_3 - 1.1e-42 145.0 0.3 2.1e-42 144.2 0.3 1.5 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain NHL PF01436.19 001081767.1_21029001_3 - 7e-28 95.1 9.5 3.4e-07 29.9 0.3 5.7 5 0 0 5 5 5 4 NHL repeat Cu2_monooxygen PF01082.18 001081767.1_21029001_3 - 1.6e-23 83.3 0.0 3.6e-23 82.1 0.0 1.7 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain SGL PF08450.10 001081767.1_21029001_3 - 0.002 17.6 0.0 1.6 8.2 0.0 3.3 2 1 0 3 3 3 1 SMP-30/Gluconolaconase/LRE-like region DUF1489 PF07370.9 001081767.1_21029001_3 - 0.088 12.4 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1489) Motilin_ghrelin PF04644.10 001081767.1_21029001_3 - 0.19 11.4 1.3 0.52 10.1 1.3 1.8 1 0 0 1 1 1 0 Motilin/ghrelin LRRC37AB_C PF14914.4 001081767.1_21029001_3 - 0.27 11.0 2.3 18 5.1 0.5 2.4 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain PNMA PF14893.4 001257075.2_21026001_3 - 1.2e-133 445.5 1.9 1.6e-133 445.1 1.9 1.2 1 0 0 1 1 1 1 PNMA zf-CCHC PF00098.21 001257075.2_21026001_3 - 0.0017 18.2 2.1 0.0042 17.0 2.1 1.7 1 0 0 1 1 1 1 Zinc knuckle SAPS PF04499.13 001113235.1_21029001_1 - 3e-104 349.4 10.1 6.8e-66 222.9 5.1 3.4 2 2 1 3 3 3 2 SIT4 phosphatase-associated protein PAX PF00292.16 001317254.1_21024001_3 - 7.7e-74 245.4 0.8 1.2e-73 244.8 0.8 1.3 1 0 0 1 1 1 1 'Paired box' domain Homeobox PF00046.27 001317254.1_21024001_3 - 1.5e-23 82.2 6.8 3.5e-23 81.0 6.8 1.6 1 0 0 1 1 1 1 Homeobox domain Pax7 PF12360.6 001317254.1_21024001_3 - 5.1e-20 71.3 8.6 1.1e-19 70.3 8.6 1.6 1 0 0 1 1 1 1 Paired box protein 7 Homeobox_KN PF05920.9 001317254.1_21024001_3 - 3.9e-05 23.3 0.8 0.00012 21.8 0.8 1.8 1 0 0 1 1 1 1 Homeobox KN domain HTH_23 PF13384.4 001317254.1_21024001_3 - 9.7e-05 21.9 2.1 0.0032 17.1 0.1 2.6 2 0 0 2 2 2 1 Homeodomain-like domain Hexokinase_2 PF03727.14 001081776.1_21027001_1 - 1e-177 588.1 1.6 4.2e-89 298.0 0.1 2.2 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.19 001081776.1_21027001_1 - 1.1e-153 508.4 0.1 1.4e-76 256.8 0.0 2.2 2 0 0 2 2 2 2 Hexokinase FGGY_N PF00370.19 001081776.1_21027001_1 - 0.0034 16.9 0.0 1.6 8.1 0.0 2.2 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain Ldh_1_N PF00056.21 001144880.1_21024001_1 - 1.1e-49 168.0 0.5 1.5e-49 167.6 0.5 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 001144880.1_21024001_1 - 8.8e-24 84.2 0.0 1.7e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.14 001144880.1_21024001_1 - 0.026 13.9 0.5 0.069 12.6 0.0 1.8 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase Pyr_redox_2 PF07992.12 001144880.1_21024001_1 - 0.058 12.5 0.0 0.093 11.8 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RGS PF00615.17 001144133.1_21022001_1 - 7.8e-39 132.5 4.8 1.4e-38 131.7 4.8 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain Renin_r PF07850.12 001309406.1_21025001_1 - 6.4e-36 122.8 1.0 1e-35 122.2 1.0 1.3 1 0 0 1 1 1 1 Renin receptor-like protein Ribosomal_L18 PF17135.2 001195513.1_21022001_2 - 2.4e-95 317.1 3.9 2.7e-95 317.0 3.9 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.17 001195513.1_21022001_2 - 0.018 15.6 0.1 0.031 14.8 0.1 1.5 1 1 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Methyltransf_4 PF02390.15 001301208.1_21023001_1 - 1e-58 197.5 0.0 1.3e-58 197.1 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.4 001301208.1_21023001_1 - 0.018 15.6 0.0 0.031 14.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Snurportin1 PF11538.6 001309333.1_21024001_2 - 1.1e-17 63.9 9.0 1.8e-17 63.1 9.0 1.4 1 0 0 1 1 1 1 Snurportin1 mRNA_cap_enzyme PF01331.17 001309333.1_21024001_2 - 0.079 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 mRNA capping enzyme, catalytic domain IBB PF01749.18 001309333.1_21024001_2 - 0.12 12.6 3.1 0.23 11.7 3.1 1.4 1 0 0 1 1 1 0 Importin beta binding domain DUF3936 PF13072.4 001309333.1_21024001_3 - 0.12 12.0 2.2 0.28 10.9 2.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3936) V-set PF07686.15 001283080.1_21022001_3 - 7.1e-09 35.7 1.4 3.8e-08 33.3 0.1 2.4 2 1 0 2 2 2 1 Immunoglobulin V-set domain Receptor_2B4 PF11465.6 001283080.1_21022001_3 - 3.5e-07 30.2 0.1 7.4e-07 29.2 0.1 1.6 1 0 0 1 1 1 1 Natural killer cell receptor 2B4 I-set PF07679.14 001283080.1_21022001_3 - 5.5e-06 26.2 1.2 0.0025 17.7 0.1 3.0 2 1 0 3 3 3 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001283080.1_21022001_3 - 1.2e-05 25.7 3.9 0.062 13.8 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001283080.1_21022001_3 - 3e-05 24.1 1.9 9.6e-05 22.5 1.3 2.0 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001283080.1_21022001_3 - 0.021 14.9 0.8 0.22 11.6 0.2 2.3 2 0 0 2 2 2 0 Immunoglobulin domain TRAP-gamma PF07074.10 001309293.1_21022001_2 - 2.1e-83 277.8 7.7 2.7e-83 277.5 7.7 1.1 1 0 0 1 1 1 1 Translocon-associated protein, gamma subunit (TRAP-gamma) Renin_r PF07850.12 001309293.1_21022001_2 - 0.036 14.5 0.7 0.5 10.9 0.3 2.1 2 0 0 2 2 2 0 Renin receptor-like protein 7tm_1 PF00001.19 001081784.1_21023001_1 - 4.3e-68 229.3 12.7 6.2e-68 228.8 12.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001081784.1_21023001_1 - 5.1e-16 58.7 17.0 7.7e-16 58.1 17.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001081784.1_21023001_1 - 1.8e-07 31.1 7.9 1.8e-07 31.1 7.9 2.0 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001081784.1_21023001_1 - 4.6e-06 26.0 8.5 4.6e-06 26.0 8.5 3.0 2 1 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx Ly49 PF08391.8 001081924.1_21022001_2 - 3.5e-49 166.0 5.2 5.6e-49 165.3 5.2 1.3 1 0 0 1 1 1 1 Ly49-like protein, N-terminal region Lectin_C PF00059.19 001081924.1_21022001_2 - 8.3e-15 55.3 5.2 1.4e-14 54.5 5.2 1.4 1 0 0 1 1 1 1 Lectin C-type domain DUF59 PF01883.17 001099442.1_21022001_1 - 1.9e-08 34.2 0.0 3.6e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF59 Ig_2 PF13895.4 001099767.2_21022001_3 - 1.5e-15 57.2 3.8 9.6e-09 35.3 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001099767.2_21022001_3 - 1.2e-13 51.3 4.5 3.1e-07 30.8 1.8 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_4 PF16680.3 001099767.2_21022001_3 - 4.5e-07 30.0 2.9 0.013 15.7 0.3 2.3 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain ig PF00047.23 001099767.2_21022001_3 - 5e-07 29.7 7.8 0.0016 18.5 2.6 3.6 2 2 0 2 2 2 2 Immunoglobulin domain Ig_5 PF16681.3 001099767.2_21022001_3 - 7.3e-07 29.4 3.2 0.00043 20.5 0.2 2.2 2 0 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.15 001099767.2_21022001_3 - 2.1e-06 27.7 6.1 0.11 12.5 0.1 3.9 2 2 2 4 4 4 3 Immunoglobulin V-set domain I-set PF07679.14 001099767.2_21022001_3 - 0.00021 21.2 0.5 0.46 10.5 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin I-set domain Tad PF13400.4 001099767.2_21022001_3 - 0.091 13.0 0.2 0.16 12.1 0.2 1.4 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like TadE PF07811.10 001099767.2_21022001_3 - 0.13 12.5 2.3 0.29 11.3 2.3 1.5 1 0 0 1 1 1 0 TadE-like protein Izumo-Ig PF16706.3 001099767.2_21022001_3 - 0.15 12.0 0.3 5.1 7.1 0.0 2.4 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Cytochrom_C PF00034.19 001164014.1_21021001_1 - 8.1e-14 52.4 0.1 1.1e-13 52.0 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.4 001164014.1_21021001_1 - 4.8e-07 29.9 3.1 2.7e-06 27.5 3.1 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.4 001164014.1_21021001_1 - 9.7e-05 22.0 3.1 0.0012 18.4 3.1 2.1 1 1 0 1 1 1 1 Cytochrome c-550 domain CCP_MauG PF03150.12 001164014.1_21021001_1 - 0.12 12.9 0.0 0.13 12.8 0.0 1.2 1 0 0 1 1 1 0 Di-haem cytochrome c peroxidase LRR_8 PF13855.4 001081925.2_21023001_1 - 8.3e-41 137.4 18.3 1.7e-15 56.4 2.4 4.6 3 2 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 001081925.2_21023001_1 - 9.9e-22 76.5 20.7 6.8e-05 23.0 1.7 6.2 2 1 4 7 7 7 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001081925.2_21023001_1 - 1.9e-10 40.4 5.0 1.3e-05 24.7 2.4 3.3 2 1 2 4 4 4 3 Leucine-rich repeat LRR_5 PF13306.4 001081925.2_21023001_1 - 2.8e-10 40.1 0.1 0.00031 20.5 0.1 3.1 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRRNT PF01462.16 001081925.2_21023001_1 - 5.4e-10 38.5 5.6 5.4e-10 38.5 5.6 2.4 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 001081925.2_21023001_1 - 0.00011 22.0 8.9 22 5.9 0.0 7.3 7 1 0 7 7 7 0 Leucine Rich Repeat LRR_6 PF13516.4 001081925.2_21023001_1 - 0.00042 20.0 16.2 0.44 10.6 0.0 7.3 8 0 0 8 8 8 2 Leucine Rich repeat STAR_dimer PF16544.3 001081925.2_21023001_1 - 0.48 9.9 0.1 0.48 9.9 0.1 2.5 2 0 0 2 2 2 0 Homodimerisation region of STAR domain protein EF1G PF00647.17 001081785.1_21023001_2 - 3e-53 178.3 0.3 5.3e-53 177.5 0.3 1.4 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.18 001081785.1_21023001_2 - 3e-23 81.8 0.0 7.6e-23 80.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001081785.1_21023001_2 - 1.4e-19 70.0 1.9 3.3e-19 68.8 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 001081785.1_21023001_2 - 2.2e-10 40.2 0.0 6.6e-10 38.7 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 001081785.1_21023001_2 - 1.2e-06 28.5 0.5 3.5e-06 27.0 0.0 2.1 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001081785.1_21023001_2 - 1.8e-06 28.1 0.0 4.3e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 001081785.1_21023001_2 - 0.0015 18.7 0.0 0.0035 17.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain NUC194 PF08163.10 001081785.1_21023001_2 - 0.14 11.2 0.7 0.64 9.0 0.4 1.9 2 0 0 2 2 2 0 NUC194 domain SAPS PF04499.13 001081785.1_21023001_2 - 0.18 10.4 0.2 0.23 10.1 0.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF1241 PF06840.9 001283070.1_21022001_3 - 1.5e-62 209.6 3.3 2e-62 209.2 3.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Focal_AT PF03623.11 001283070.1_21022001_3 - 0.023 14.5 0.1 0.053 13.3 0.1 1.6 1 0 0 1 1 1 0 Focal adhesion targeting region CENP-L PF13092.4 001283070.1_21022001_3 - 0.033 14.3 0.1 0.045 13.8 0.1 1.2 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 Syntaxin_2 PF14523.4 001283070.1_21022001_3 - 0.042 14.1 2.3 0.076 13.3 2.3 1.4 1 0 0 1 1 1 0 Syntaxin-like protein Med11 PF10280.7 001283070.1_21022001_3 - 0.059 13.7 0.6 0.11 12.8 0.2 1.7 2 0 0 2 2 2 0 Mediator complex protein GCN5L1 PF06320.11 001283070.1_21022001_3 - 0.16 12.0 2.0 0.76 9.8 1.1 2.1 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) UQ_con PF00179.24 001301162.1_21023001_1 - 3.8e-17 62.1 0.0 5.3e-17 61.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme IL8 PF00048.18 001309480.1_21023001_1 - 1e-14 54.3 1.0 2.1e-14 53.3 1.0 1.5 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like RRM_1 PF00076.20 001195588.1_21023001_2 - 1.6e-16 59.7 0.0 2.4e-16 59.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001195588.1_21023001_2 - 0.00078 18.9 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.21 001195588.1_21023001_2 - 0.00083 19.2 7.7 0.0018 18.2 7.7 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.4 001195588.1_21023001_2 - 0.0013 18.5 2.5 0.0037 17.0 2.5 1.8 1 0 0 1 1 1 1 Zinc knuckle Sec63 PF02889.14 001308369.1_21029001_1 - 5.8e-177 585.9 7.0 1.2e-94 316.2 1.5 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.27 001308369.1_21029001_1 - 9.9e-53 178.4 0.1 7.6e-25 87.6 0.0 3.1 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.13 001308369.1_21029001_1 - 4.2e-26 91.8 0.0 1.3e-11 44.6 0.0 3.1 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.29 001308369.1_21029001_1 - 1.9e-13 50.6 0.0 1.1e-06 28.8 0.0 3.9 3 2 0 3 3 2 2 Helicase conserved C-terminal domain AAA_30 PF13604.4 001308369.1_21029001_1 - 5.8e-08 32.6 0.0 0.0063 16.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.4 001308369.1_21029001_1 - 7.8e-08 32.6 0.0 0.0048 17.0 0.0 3.4 2 0 0 2 2 2 2 AAA domain PhoH PF02562.14 001308369.1_21029001_1 - 0.00028 20.3 0.0 0.12 11.7 0.0 2.8 2 0 0 2 2 2 2 PhoH-like protein T2SSE PF00437.18 001308369.1_21029001_1 - 0.0017 17.4 0.0 1.4 7.8 0.0 2.6 2 0 0 2 2 2 2 Type II/IV secretion system protein DUF603 PF04645.10 001308369.1_21029001_1 - 0.017 14.7 0.1 0.038 13.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF603 IstB_IS21 PF01695.15 001308369.1_21029001_1 - 0.068 12.8 0.0 2.4 7.8 0.0 2.7 2 0 0 2 2 2 0 IstB-like ATP binding protein UvrD-helicase PF00580.19 001308369.1_21029001_1 - 0.074 12.4 0.0 16 4.7 0.0 3.0 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain Sigma54_activ_2 PF14532.4 001308369.1_21029001_1 - 0.1 12.6 0.1 1.9 8.4 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_11 PF13086.4 001308369.1_21029001_1 - 0.29 10.7 1.5 5 6.6 0.0 3.3 4 0 0 4 4 4 0 AAA domain Globin PF00042.20 001164018.1_21021001_1 - 5.3e-31 107.3 0.1 4.4e-30 104.3 0.0 1.9 2 0 0 2 2 2 1 Globin SCF PF02404.13 001163962.1_21023001_1 - 6.7e-152 504.3 5.3 7.9e-152 504.1 5.3 1.0 1 0 0 1 1 1 1 Stem cell factor DUF4448 PF14610.4 001163962.1_21023001_1 - 0.04 13.6 0.0 0.062 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) UQ_con PF00179.24 001309314.1_21025001_2 - 2.3e-46 156.8 0.0 3.2e-46 156.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.4 001309314.1_21025001_2 - 0.016 14.8 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B UEV PF05743.11 001309314.1_21025001_2 - 0.06 13.1 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 UEV domain RtcB PF01139.15 001286858.1_21028001_1 - 3.9e-145 484.0 0.2 4.6e-145 483.8 0.2 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB Ribosomal_L6e PF01159.17 001309265.1_21022001_3 - 7.9e-45 151.7 1.0 7.9e-45 151.7 1.0 2.7 3 0 0 3 3 3 1 Ribosomal protein L6e Ribosomal_L6e_N PF03868.13 001309265.1_21022001_3 - 1.3e-35 121.2 10.5 1.3e-35 121.2 10.5 3.3 2 1 1 3 3 3 1 Ribosomal protein L6, N-terminal domain LRR_8 PF13855.4 001081796.1_21027001_2 - 3.1e-38 129.2 44.2 7.9e-12 44.6 9.3 8.8 6 2 2 8 8 8 8 Leucine rich repeat LRR_4 PF12799.5 001081796.1_21027001_2 - 3.1e-23 81.2 45.3 0.00012 22.2 1.7 9.0 9 0 0 9 9 9 6 Leucine Rich repeats (2 copies) TIR PF01582.18 001081796.1_21027001_2 - 5.1e-22 78.4 0.3 1e-21 77.4 0.3 1.5 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.4 001081796.1_21027001_2 - 2.1e-09 37.5 0.0 4e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 TIR domain LRR_9 PF14580.4 001081796.1_21027001_2 - 3.5e-08 33.0 14.0 8.9e-05 21.9 0.2 4.3 2 2 2 4 4 4 2 Leucine-rich repeat LRR_5 PF13306.4 001081796.1_21027001_2 - 8.6e-08 32.1 15.1 3.3e-06 26.9 0.5 4.6 2 2 2 4 4 4 2 Leucine rich repeats (6 copies) LRR_1 PF00560.31 001081796.1_21027001_2 - 1.5e-06 27.7 35.9 0.46 11.0 3.4 11.8 12 0 0 12 12 12 2 Leucine Rich Repeat LRRCT PF01463.22 001081796.1_21027001_2 - 8.9e-05 22.6 0.1 0.00054 20.2 0.1 2.5 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain LRR_6 PF13516.4 001081796.1_21027001_2 - 0.0061 16.4 36.8 7.1 6.8 2.3 9.7 10 0 0 10 10 10 3 Leucine Rich repeat DUF1863 PF08937.9 001081796.1_21027001_2 - 0.038 14.2 0.0 0.13 12.4 0.0 1.9 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) Bromodomain PF00439.23 001309160.1_21028001_1 - 2.7e-10 40.0 0.1 6.5e-10 38.8 0.1 1.6 1 0 0 1 1 1 1 Bromodomain PWWP PF00855.15 001309160.1_21028001_1 - 7.8e-10 39.0 0.6 7.8e-10 39.0 0.6 3.4 3 1 0 3 3 3 1 PWWP domain DUF1002 PF06207.9 001309160.1_21028001_1 - 0.12 11.7 1.3 0.28 10.6 1.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) Spore_III_AB PF09548.8 001309160.1_21028001_1 - 3.3 7.7 7.1 1.5 8.8 4.4 1.8 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Peptidase_S64 PF08192.9 001309160.1_21028001_1 - 3.8 5.7 17.2 5.8 5.1 17.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 Ig_2 PF13895.4 001317252.1_21022001_1 - 9.3e-24 83.4 0.7 9.4e-12 45.0 0.0 2.6 3 0 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.4 001317252.1_21022001_1 - 1.6e-18 67.0 0.3 4.7e-08 33.4 0.2 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001317252.1_21022001_1 - 1.6e-11 44.0 0.6 0.00016 21.6 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.3 001317252.1_21022001_1 - 1.1e-10 41.6 0.1 5.7e-05 23.3 0.0 2.3 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain V-set PF07686.15 001317252.1_21022001_1 - 1.9e-10 40.7 1.7 0.0019 18.2 0.0 3.8 3 2 1 4 4 4 2 Immunoglobulin V-set domain I-set PF07679.14 001317252.1_21022001_1 - 1.2e-07 31.6 0.9 0.0026 17.7 0.0 3.3 3 2 0 3 3 3 2 Immunoglobulin I-set domain Ig_5 PF16681.3 001317252.1_21022001_1 - 6.7e-06 26.3 0.2 0.0048 17.2 0.0 2.3 2 0 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set PF05790.13 001317252.1_21022001_1 - 3.1e-05 24.0 0.0 0.14 12.2 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin C2-set domain Receptor_2B4 PF11465.6 001317252.1_21022001_1 - 0.014 15.5 0.0 4.5 7.4 0.0 2.6 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 IL8 PF00048.18 001081931.2_21022001_1 - 2.2e-21 75.6 2.2 3.8e-21 74.9 2.2 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Pkinase_Tyr PF07714.15 001163866.1_21027001_2 - 3.6e-103 344.2 0.0 5.2e-103 343.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001163866.1_21027001_2 - 1.9e-43 148.6 0.0 1.3e-30 106.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 001163866.1_21027001_2 - 2.7e-23 82.2 7.0 1.9e-07 31.5 0.1 4.8 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 001163866.1_21027001_2 - 7.8e-15 54.7 8.7 3.4e-13 49.4 0.3 3.9 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.14 001163866.1_21027001_2 - 1.6e-13 50.4 8.3 1.4e-07 31.4 0.1 5.4 5 2 0 5 5 5 3 Immunoglobulin I-set domain Ig_2 PF13895.4 001163866.1_21027001_2 - 3e-10 40.1 7.7 0.0047 17.1 0.1 5.2 5 1 0 5 5 5 3 Immunoglobulin domain C2-set_2 PF08205.10 001163866.1_21027001_2 - 0.00014 21.7 0.2 0.83 9.6 0.0 3.1 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 001163866.1_21027001_2 - 0.00034 20.9 2.6 0.0013 19.0 0.1 3.0 3 0 0 3 3 3 1 Immunoglobulin C1-set domain Ig_4 PF16680.3 001163866.1_21027001_2 - 0.0038 17.4 0.1 0.19 12.0 0.0 3.1 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain V-set PF07686.15 001163866.1_21027001_2 - 0.015 15.3 10.9 0.49 10.4 0.2 5.6 5 3 1 6 6 6 0 Immunoglobulin V-set domain APH PF01636.21 001163866.1_21027001_2 - 0.087 12.6 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Annexin PF00191.18 001123380.2_21023001_2 - 1.7e-92 303.3 12.5 3.2e-27 94.2 0.5 4.2 4 0 0 4 4 4 4 Annexin Agouti PF05039.10 001164017.1_21021001_1 - 2.4e-29 101.7 16.3 3.2e-29 101.3 16.3 1.2 1 0 0 1 1 1 1 Agouti protein ETRAMP PF09716.8 001164017.1_21021001_1 - 0.0025 17.7 1.0 0.0046 16.9 1.0 1.4 1 0 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) Toxin_9 PF02819.13 001164017.1_21021001_1 - 0.23 11.7 16.7 0.33 11.1 16.7 1.3 1 0 0 1 1 1 0 Spider toxin Chordopox_A30L PF06015.10 001164017.1_21021001_1 - 3.7 7.3 7.8 5.4 6.8 7.2 1.6 1 1 0 1 1 1 0 Chordopoxvirus A30L protein CAP PF00188.24 001081932.1_21023001_3 - 3.4e-23 82.7 4.1 5e-23 82.2 4.1 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Crisp PF08562.8 001081932.1_21023001_3 - 4e-20 72.0 21.1 1.5e-19 70.2 21.1 2.0 1 0 0 1 1 1 1 Crisp WD40 PF00400.30 001242446.1_21023001_1 - 2.5e-49 164.0 25.3 8.3e-09 35.8 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001242446.1_21023001_1 - 2.1e-10 40.6 0.9 0.0036 17.4 0.0 4.6 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001242446.1_21023001_1 - 5.1e-05 23.1 0.2 0.0061 16.3 0.0 2.7 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 001242446.1_21023001_1 - 0.0001 21.2 0.1 0.75 8.6 0.0 4.0 2 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.14 001242446.1_21023001_1 - 0.0073 14.7 0.0 0.032 12.6 0.1 1.9 1 1 1 2 2 2 1 Cytochrome D1 heme domain WD40_like PF17005.3 001242446.1_21023001_1 - 0.01 15.1 0.0 3.2 6.9 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain Nup160 PF11715.6 001242446.1_21023001_1 - 0.015 13.8 10.8 0.15 10.5 0.1 4.4 3 2 2 5 5 5 0 Nucleoporin Nup120/160 PD40 PF07676.10 001242446.1_21023001_1 - 0.18 11.7 2.5 18 5.3 0.0 4.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat DUF4431 PF14485.4 001242446.1_21023001_3 - 0.65 9.7 2.6 0.61 9.8 0.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4431) Sulfate_transp PF00916.18 001081934.2_21025001_1 - 7.5e-133 442.8 19.2 1.1e-132 442.3 19.2 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 001081934.2_21025001_1 - 5.9e-30 103.2 0.0 1.2e-29 102.2 0.0 1.5 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.4 001081934.2_21025001_1 - 0.021 15.0 0.0 0.047 13.9 0.0 1.5 1 0 0 1 1 1 0 STAS domain Lectin_C PF00059.19 001081812.2_21022001_2 - 8.4e-20 71.4 0.0 1.2e-19 70.9 0.0 1.2 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 001081812.2_21022001_2 - 1.7e-10 40.4 36.1 5.2e-05 22.8 18.9 2.3 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) ig PF00047.23 001081816.1_21023001_2 - 1.6e-18 66.5 2.0 2.3e-07 30.8 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 001081816.1_21023001_2 - 4.6e-17 62.3 0.9 0.00034 21.0 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001081816.1_21023001_2 - 1.8e-15 56.9 0.9 7.1e-06 26.2 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 001081816.1_21023001_2 - 1.8e-11 43.8 0.9 0.00016 21.6 0.1 3.1 3 1 0 3 3 3 2 Immunoglobulin I-set domain Izumo-Ig PF16706.3 001081816.1_21023001_2 - 9.8e-07 28.6 0.3 0.01 15.7 0.0 2.5 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain V-set PF07686.15 001081816.1_21023001_2 - 5e-06 26.5 10.0 0.0082 16.2 0.1 4.7 3 2 1 4 4 4 2 Immunoglobulin V-set domain Ig_5 PF16681.3 001081816.1_21023001_2 - 0.0014 18.8 1.4 0.25 11.7 0.0 3.2 2 2 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Sec20 PF03908.11 001309271.1_21024001_2 - 0.00011 21.9 0.5 0.00017 21.3 0.5 1.3 1 0 0 1 1 1 1 Sec20 Use1 PF09753.7 001309271.1_21024001_2 - 0.00038 20.1 0.3 0.00053 19.6 0.3 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 DUF4407 PF14362.4 001309271.1_21024001_2 - 0.021 14.0 0.0 0.028 13.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ski_Sno PF02437.15 001081818.1_21025001_1 - 8.4e-45 150.9 0.3 1.7e-44 149.9 0.3 1.5 1 0 0 1 1 1 1 SKI/SNO/DAC family c-SKI_SMAD_bind PF08782.8 001081818.1_21025001_1 - 4.5e-39 132.5 1.3 1.2e-38 131.1 1.3 1.8 1 0 0 1 1 1 1 c-SKI Smad4 binding domain AAA_13 PF13166.4 001081818.1_21025001_1 - 0.025 13.1 6.8 0.037 12.6 6.8 1.2 1 0 0 1 1 1 0 AAA domain DUF4407 PF14362.4 001081818.1_21025001_1 - 9.2 5.4 15.1 15 4.7 15.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OAS1_C PF10421.7 001082489.1_21024001_2 - 5.7e-87 289.9 0.0 7.6e-87 289.5 0.0 1.2 1 0 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus NTP_transf_2 PF01909.21 001082489.1_21024001_2 - 4.9e-08 33.0 0.0 9.5e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain KNOX2 PF03791.11 001082489.1_21024001_2 - 0.019 14.5 0.4 3.8 7.1 0.2 2.6 2 0 0 2 2 2 0 KNOX2 domain DZF PF07528.12 001082489.1_21024001_2 - 0.046 13.2 0.0 0.35 10.3 0.0 2.0 1 1 0 1 1 1 0 DZF domain RRM_1 PF00076.20 001309238.1_21029001_1 - 5.2e-50 167.0 0.0 1.7e-17 62.9 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.9 001309238.1_21029001_1 - 5.7e-07 29.3 0.0 0.3 11.0 0.0 3.5 3 0 0 3 3 3 3 RNA binding domain RRM_7 PF16367.3 001309238.1_21029001_1 - 0.00068 19.6 0.0 1.2 9.1 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.4 001309238.1_21029001_1 - 0.033 14.0 0.0 1.6 8.6 0.0 3.0 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.4 001309238.1_21029001_1 - 0.28 11.3 2.3 7.5 6.6 0.2 2.9 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter NDK PF00334.17 001301143.1_21023001_3 - 2.4e-75 250.9 0.0 1.2e-38 132.1 0.0 2.1 2 0 0 2 2 2 2 Nucleoside diphosphate kinase DUF1126 PF06565.10 001301143.1_21023001_3 - 0.00016 21.3 0.1 0.00033 20.3 0.1 1.5 1 0 0 1 1 1 1 DUF1126 PH-like domain ACT_5 PF13710.4 001301143.1_21023001_3 - 0.00062 19.4 0.2 0.062 13.0 0.0 2.3 2 0 0 2 2 2 1 ACT domain Arg_repressor PF01316.19 001301143.1_21023001_3 - 0.13 11.9 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain Glycogen_syn PF05693.11 001126125.2_21027001_1 - 0 1207.3 0.0 0 1207.0 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_4 PF13439.4 001126125.2_21027001_1 - 1.3e-06 28.3 0.1 2.3e-06 27.6 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.18 001126125.2_21027001_1 - 3e-05 23.5 0.1 0.0011 18.5 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.4 001126125.2_21027001_1 - 0.00017 21.9 0.1 0.00044 20.6 0.1 1.7 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.4 001126125.2_21027001_1 - 0.00028 21.2 0.0 0.02 15.2 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferases group 1 GSHPx PF00255.17 001115158.1_21024001_2 - 3.4e-36 123.0 0.1 4.8e-36 122.5 0.1 1.2 1 0 0 1 1 1 1 Glutathione peroxidase FKBP_C PF00254.26 001081937.1_21023001_2 - 9e-08 32.2 0.0 2.9e-07 30.6 0.0 1.8 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.15 001081937.1_21023001_2 - 9e-06 25.3 3.4 0.00091 19.0 0.4 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 001081937.1_21023001_2 - 0.052 13.7 1.4 0.18 12.0 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 001081937.1_21023001_2 - 1.1 9.1 5.2 1.4 8.8 0.2 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.4 001081937.1_21023001_2 - 1.1 8.9 6.4 7.1 6.3 0.0 3.2 3 0 0 3 3 3 0 TPR repeat P21-Arc PF04062.12 001309270.1_21022001_3 - 1.2e-81 272.8 0.2 1.4e-81 272.5 0.2 1.1 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit MHC_I_3 PF16497.3 001159692.1_21023001_2 - 5.3e-96 319.7 0.2 7e-96 319.3 0.2 1.2 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001159692.1_21023001_2 - 1.6e-10 41.2 0.0 3.4e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001159692.1_21023001_2 - 5e-06 26.1 0.0 8e-06 25.4 0.0 1.4 1 1 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_3 PF13927.4 001159692.1_21023001_2 - 0.019 15.4 0.1 0.68 10.5 0.0 2.4 1 1 1 2 2 2 0 Immunoglobulin domain ig PF00047.23 001159692.1_21023001_2 - 0.062 13.3 0.0 0.45 10.6 0.0 2.2 1 1 1 2 2 2 0 Immunoglobulin domain Homeobox PF00046.27 001159692.1_21023001_2 - 0.063 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Homeobox domain Peptidase_C12 PF01088.19 001081820.1_21023001_1 - 1.5e-58 197.9 0.1 1.8e-58 197.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 HSP90 PF00183.16 001081938.1_21026001_3 - 9e-243 806.6 27.8 1.2e-242 806.3 27.8 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.24 001081938.1_21026001_3 - 1.9e-13 50.8 0.0 3.7e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.4 001081938.1_21026001_3 - 3e-10 39.9 0.1 8.3e-10 38.5 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CDC45 PF02724.12 001081938.1_21026001_3 - 8 4.5 14.0 15 3.6 14.0 1.3 1 0 0 1 1 1 0 CDC45-like protein ASC PF00858.22 001195635.1_21026001_2 - 7.5e-100 334.6 0.1 9.4e-100 334.3 0.1 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Cys_knot PF00007.20 001197093.1_21022001_1 - 4.8e-33 113.5 4.6 5.8e-33 113.2 4.6 1.1 1 0 0 1 1 1 1 Cystine-knot domain JAB PF01398.19 001309280.1_21023001_1 - 6.8e-34 116.2 0.0 1.3e-33 115.3 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.4 001309280.1_21023001_1 - 0.00024 20.7 0.0 0.0004 20.0 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.11 001309280.1_21023001_1 - 0.007 16.3 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) Thyroglobulin_1 PF00086.16 001308604.1_21022001_3 - 3.6e-18 64.8 4.2 3.6e-18 64.8 4.2 2.8 3 0 0 3 3 3 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 001308604.1_21022001_3 - 2.3e-05 24.8 17.4 2.3e-05 24.8 17.4 2.4 2 0 0 2 2 2 1 Insulin-like growth factor binding protein Hexapep PF00132.22 001309312.1_21022001_2 - 1.1e-08 34.3 16.6 6.3e-05 22.4 1.2 4.4 4 1 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.4 001309312.1_21022001_2 - 2.8 7.6 6.9 16 5.2 0.2 2.9 2 0 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase MHC_I_3 PF16497.3 001252307.1_21023001_1 - 1.3e-89 298.9 0.1 1.6e-89 298.5 0.1 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001252307.1_21023001_1 - 3e-10 40.3 0.0 5.1e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001252307.1_21023001_1 - 0.00022 20.7 0.0 0.00032 20.2 0.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Calx-beta PF03160.12 001309515.1_21027001_3 - 7.2e-65 215.3 11.5 8.1e-36 122.1 1.7 2.7 3 0 0 3 3 3 2 Calx-beta domain Na_Ca_ex PF01699.22 001309515.1_21027001_3 - 3.4e-61 205.5 36.2 1.9e-35 122.0 11.3 2.6 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Na_Ca_ex_C PF16494.3 001309515.1_21027001_3 - 5.4e-51 172.2 5.8 1e-50 171.3 5.8 1.5 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain DnaG_DnaB_bind PF08278.9 001309515.1_21027001_3 - 0.044 14.2 1.8 0.093 13.2 1.8 1.4 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding MH2 PF03166.12 001163882.1_21026001_2 - 7.6e-76 254.3 1.5 1e-75 253.9 1.5 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 001163882.1_21026001_2 - 6.3e-42 141.9 1.2 1.5e-41 140.6 1.2 1.7 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.7 001163882.1_21026001_2 - 0.00035 20.3 0.0 0.0007 19.3 0.0 1.4 1 0 0 1 1 1 1 Interferon-regulatory factor 3 MHC_II_alpha PF00993.18 001284542.1_21023001_2 - 2.6e-36 123.0 0.2 3.9e-36 122.5 0.2 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001284542.1_21023001_2 - 6.9e-29 98.9 0.8 1.4e-28 97.9 0.8 1.5 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001284542.1_21023001_2 - 1.4e-22 79.8 0.0 2.1e-22 79.3 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001284542.1_21023001_2 - 2.2e-05 24.9 0.0 3.5e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001284542.1_21023001_2 - 0.00055 19.7 0.0 0.00088 19.0 0.0 1.2 1 0 0 1 1 1 1 Marek's disease glycoprotein A MH2 PF03166.12 001163888.1_21026001_3 - 3.6e-75 252.1 3.0 3.7e-75 252.1 1.6 1.7 2 0 0 2 2 2 1 MH2 domain MH1 PF03165.14 001163888.1_21026001_3 - 5.7e-42 142.0 0.3 1.5e-41 140.6 0.3 1.8 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.7 001163888.1_21026001_3 - 0.0012 18.6 0.0 0.002 17.8 0.0 1.3 1 0 0 1 1 1 1 Interferon-regulatory factor 3 OATP PF03137.18 001309511.1_21025001_1 - 3e-174 580.2 23.7 3.5e-174 580.0 23.7 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 001309511.1_21025001_1 - 7.4e-28 97.3 12.0 1.5e-27 96.3 6.4 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Kazal_2 PF07648.13 001309511.1_21025001_1 - 1.9e-09 37.4 1.9 4.2e-09 36.3 1.9 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 001309511.1_21025001_1 - 0.0006 19.6 3.1 0.0006 19.6 3.1 2.3 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain Skp1 PF01466.17 001309511.1_21025001_1 - 0.35 10.9 0.0 0.35 10.9 0.0 2.2 2 0 0 2 2 2 0 Skp1 family, dimerisation domain PAX PF00292.16 001267712.2_21023001_3 - 1.9e-74 247.4 0.7 3.3e-74 246.6 0.7 1.4 1 0 0 1 1 1 1 'Paired box' domain Pax2_C PF12403.6 001267712.2_21023001_3 - 2.9e-50 169.0 14.2 2.9e-50 169.0 14.2 1.9 2 0 0 2 2 2 1 Paired-box protein 2 C terminal HTH_32 PF13565.4 001267712.2_21023001_3 - 3.9e-06 27.3 0.2 0.0028 18.1 0.0 2.4 1 1 1 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.4 001267712.2_21023001_3 - 6.8e-05 22.4 0.0 0.00023 20.7 0.0 1.9 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.4 001267712.2_21023001_3 - 0.016 15.2 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Ribosomal_S13_N PF08069.10 001267712.2_21023001_3 - 0.055 13.4 0.1 0.18 11.8 0.0 1.8 2 0 0 2 2 2 0 Ribosomal S13/S15 N-terminal domain HTH_Tnp_IS1 PF12759.5 001267712.2_21023001_3 - 0.072 12.6 0.2 0.19 11.2 0.0 1.8 2 0 0 2 2 2 0 InsA C-terminal domain Homeobox PF00046.27 001267712.2_21023001_3 - 0.082 12.6 0.1 0.2 11.4 0.1 1.6 1 0 0 1 1 1 0 Homeobox domain MHC_II_beta PF00969.17 001142811.1_21023001_2 - 2.5e-34 117.1 0.4 4.1e-34 116.4 0.4 1.4 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001142811.1_21023001_2 - 7.1e-26 90.4 0.4 2.2e-25 88.8 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001142811.1_21023001_2 - 0.00015 22.2 0.1 0.00069 20.1 0.0 2.2 3 0 0 3 3 3 1 Immunoglobulin domain ig PF00047.23 001142811.1_21023001_2 - 0.002 18.1 0.1 0.0047 16.9 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001142811.1_21023001_2 - 0.0049 17.0 0.1 0.012 15.7 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 001142811.1_21023001_2 - 0.025 14.5 0.2 0.11 12.5 0.1 2.0 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain PAS_11 PF14598.4 001308309.1_21029001_3 - 8e-22 77.4 0.0 9.8e-20 70.6 0.0 2.8 2 0 0 2 2 2 1 PAS domain PAS_3 PF08447.10 001308309.1_21029001_3 - 1.1e-16 60.7 0.3 5.5e-15 55.3 0.1 2.4 2 0 0 2 2 2 1 PAS fold HLH PF00010.24 001308309.1_21029001_3 - 1e-08 34.9 0.6 2e-08 34.0 0.6 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS PF00989.23 001308309.1_21029001_3 - 1.5e-08 34.5 0.0 5e-07 29.6 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.5 001308309.1_21029001_3 - 0.0013 18.9 0.0 0.0038 17.3 0.0 1.8 1 0 0 1 1 1 1 PAS domain Tetraspannin PF00335.18 001253839.1_21022001_2 - 1.2e-50 172.1 19.0 1.4e-50 171.9 19.0 1.0 1 0 0 1 1 1 1 Tetraspanin family Ras PF00071.20 001253838.1_21022001_1 - 7.9e-57 191.2 0.3 9.8e-57 190.9 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001253838.1_21022001_1 - 3e-20 72.5 0.0 4.3e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001253838.1_21022001_1 - 1.9e-08 33.8 0.1 2.6e-08 33.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001253838.1_21022001_1 - 0.00025 20.5 0.3 0.00053 19.5 0.1 1.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001253838.1_21022001_1 - 0.0018 18.2 0.0 0.0026 17.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001253838.1_21022001_1 - 0.0063 16.3 2.6 1.3 8.7 0.0 2.3 1 1 0 2 2 2 2 Protein of unknown function, DUF258 G-alpha PF00503.18 001253838.1_21022001_1 - 0.0098 14.9 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 1 G-protein alpha subunit Asp PF00026.21 001081943.1_21023001_2 - 2.4e-115 385.2 0.0 2.8e-115 384.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001081943.1_21023001_2 - 1.6e-12 47.9 0.9 2e-07 31.3 0.1 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001081943.1_21023001_2 - 3.3e-10 39.5 0.8 6.6e-10 38.5 0.8 1.5 1 0 0 1 1 1 1 A1 Propeptide Tim44 PF04280.13 001286864.1_21024001_1 - 1.7e-29 102.7 0.0 2.5e-29 102.2 0.0 1.2 1 0 0 1 1 1 1 Tim44-like domain MBA1 PF07961.9 001286864.1_21024001_1 - 0.056 12.4 0.0 0.094 11.6 0.0 1.3 1 0 0 1 1 1 0 MBA1-like protein MHC_II_alpha PF00993.18 001128593.1_21023001_1 - 2.7e-36 123.0 0.2 3.8e-36 122.5 0.2 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001128593.1_21023001_1 - 3.6e-27 93.4 0.5 7e-27 92.5 0.5 1.5 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001128593.1_21023001_1 - 6.8e-23 80.8 0.0 1.1e-22 80.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001128593.1_21023001_1 - 9.1e-05 22.9 0.0 0.00017 22.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001128593.1_21023001_1 - 0.02 14.6 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 Marek's disease glycoprotein A Actin PF00022.17 001081838.1_21023001_1 - 1.2e-151 504.9 0.0 3.8e-151 503.2 0.0 1.6 1 1 0 1 1 1 1 Actin Tim17 PF02466.17 001309300.1_21023001_3 - 3e-28 98.1 3.5 4.2e-28 97.6 3.5 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family SAP PF02037.25 001309411.1_21022001_2 - 6.6e-11 41.6 3.9 3.1e-10 39.5 1.9 2.4 2 0 0 2 2 2 1 SAP domain LETM1 PF07766.11 001309411.1_21022001_2 - 0.1 11.8 0.3 0.19 10.9 0.3 1.4 1 0 0 1 1 1 0 LETM1-like protein HTH_Tnp_IS630 PF01710.14 001309411.1_21022001_2 - 0.32 10.9 4.9 6 6.8 0.3 3.2 2 1 1 3 3 3 0 Transposase ADH_zinc_N PF00107.24 001081945.1_21024001_3 - 8.7e-25 87.0 0.1 1.5e-24 86.2 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001081945.1_21024001_3 - 5.6e-24 84.0 1.0 1.1e-23 83.0 1.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.4 001081945.1_21024001_3 - 6.9e-05 23.8 0.0 0.00013 22.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.3 001081945.1_21024001_3 - 0.0001 21.7 0.0 0.00016 21.1 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.12 001081945.1_21024001_3 - 0.0027 17.2 0.2 0.0046 16.4 0.2 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.17 001081945.1_21024001_3 - 0.02 14.1 0.3 0.032 13.4 0.3 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Lipocalin PF00061.21 001163885.1_21022001_3 - 2.1e-29 102.4 2.4 2.5e-29 102.2 2.4 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001163885.1_21022001_3 - 8.3e-09 35.3 1.0 1.1e-08 35.0 1.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family 40S_SA_C PF16122.3 001143951.1_21023001_2 - 2e-28 99.5 21.0 3.3e-28 98.8 21.0 1.4 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Ribosomal_S2 PF00318.18 001143951.1_21023001_2 - 1.8e-25 89.3 0.0 1.6e-12 47.0 0.0 2.2 1 1 1 2 2 2 2 Ribosomal protein S2 Ras PF00071.20 001301245.1_21027001_3 - 8.7e-55 184.6 0.3 1.2e-54 184.2 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001301245.1_21027001_3 - 3.6e-19 69.0 0.0 5.6e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001301245.1_21027001_3 - 1.3e-07 31.1 0.1 2e-07 30.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001301245.1_21027001_3 - 0.0013 18.1 0.1 0.0023 17.4 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001301245.1_21027001_3 - 0.017 15.0 0.0 0.024 14.6 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF258 PF03193.14 001301245.1_21027001_3 - 0.034 13.9 0.0 9.5 6.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 COesterase PF00135.26 001081850.1_21024001_1 - 1.9e-179 597.8 0.0 2.2e-179 597.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family AChE_tetra PF08674.8 001081850.1_21024001_1 - 8.5e-23 79.6 9.5 8.5e-23 79.6 9.5 2.4 2 0 0 2 2 2 1 Acetylcholinesterase tetramerisation domain Abhydrolase_3 PF07859.11 001081850.1_21024001_1 - 7.3e-07 29.1 0.0 1.4e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold MHC_II_beta PF00969.17 001142813.1_21023001_1 - 2e-35 120.6 0.2 3.2e-35 120.0 0.2 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001142813.1_21023001_1 - 2.1e-27 95.3 0.1 9.2e-27 93.2 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001142813.1_21023001_1 - 3.3e-06 27.5 0.1 1e-05 25.9 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001142813.1_21023001_1 - 0.0028 17.6 0.0 0.0053 16.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 001142813.1_21023001_1 - 0.0034 17.3 0.0 0.0058 16.6 0.0 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain MHC_I PF00129.16 001142813.1_21023001_1 - 0.0059 16.1 0.0 0.0094 15.4 0.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Marek_A PF02124.13 001142813.1_21023001_1 - 0.019 14.7 0.0 0.029 14.1 0.0 1.2 1 0 0 1 1 1 0 Marek's disease glycoprotein A Clathrin_lg_ch PF01086.15 001159334.1_21023001_1 - 8.2e-58 195.9 1.1 1e-57 195.6 1.1 1.1 1 0 0 1 1 1 1 Clathrin light chain CENP-Q PF13094.4 001159334.1_21023001_1 - 0.00036 20.6 5.8 0.00052 20.1 5.8 1.2 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit SlyX PF04102.10 001159334.1_21023001_1 - 0.15 12.6 2.2 0.33 11.5 1.0 2.2 1 1 1 2 2 2 0 SlyX ORC3_N PF07034.9 001159334.1_21023001_1 - 1.9 7.3 4.9 2.8 6.8 4.9 1.1 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus IGF2_C PF08365.9 001114539.2_21022001_1 - 3.1e-25 87.8 2.6 5.3e-25 87.0 2.6 1.4 1 0 0 1 1 1 1 Insulin-like growth factor II E-peptide Insulin PF00049.16 001114539.2_21022001_1 - 2.8e-13 50.5 7.5 1.1e-06 29.4 2.1 2.6 2 1 1 3 3 3 2 Insulin/IGF/Relaxin family MHC_I_3 PF16497.3 001252303.1_21023001_1 - 8.9e-95 315.7 0.2 1.2e-94 315.3 0.2 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001252303.1_21023001_1 - 1.6e-11 44.4 0.0 2.9e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001252303.1_21023001_1 - 1.8e-06 27.5 0.0 3.5e-06 26.6 0.0 1.5 2 0 0 2 2 2 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_3 PF13927.4 001252303.1_21023001_1 - 0.065 13.7 0.0 0.15 12.5 0.0 1.6 1 1 0 1 1 1 0 Immunoglobulin domain DUF3377 PF11857.6 001252303.1_21023001_1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DUF4381 PF14316.4 001252303.1_21023001_1 - 0.25 11.5 4.3 0.12 12.5 0.7 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) MHC_II_beta PF00969.17 001142815.1_21023001_1 - 5.2e-37 125.7 0.8 7.7e-37 125.2 0.8 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001142815.1_21023001_1 - 1.8e-25 89.1 0.2 4.2e-25 87.9 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001142815.1_21023001_1 - 0.00019 21.8 0.1 0.00052 20.4 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001142815.1_21023001_1 - 0.013 15.5 0.0 0.024 14.7 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain C2-set_2 PF08205.10 001142815.1_21023001_1 - 0.086 12.8 0.1 0.23 11.4 0.1 1.7 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Mito_carr PF00153.25 001309413.1_21023001_1 - 8.2e-68 224.3 3.8 1.5e-24 85.6 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein TPR_1 PF00515.26 001309324.1_21024001_3 - 5.9e-12 44.7 1.5 3.9e-05 23.1 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 001309324.1_21024001_3 - 7.4e-12 44.3 3.8 0.018 15.0 1.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.4 001309324.1_21024001_3 - 1.7e-08 33.9 0.1 0.00082 18.9 0.0 3.0 1 1 2 3 3 3 2 TPR repeat TPR_9 PF13371.4 001309324.1_21024001_3 - 2.7e-07 30.5 2.3 1.6e-05 24.8 0.7 2.9 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.4 001309324.1_21024001_3 - 1.5e-06 28.1 0.1 0.021 15.0 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.4 001309324.1_21024001_3 - 2.1e-06 28.2 0.6 0.0096 16.5 0.1 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 001309324.1_21024001_3 - 3.4e-05 23.6 0.2 0.041 14.0 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.4 001309324.1_21024001_3 - 0.00019 21.9 6.1 0.083 13.6 0.0 3.9 2 1 2 4 4 4 2 Tetratricopeptide repeat Rrn6 PF10214.7 001309324.1_21024001_3 - 0.015 13.6 0.0 0.015 13.6 0.0 1.4 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor Hox9_act PF04617.11 001309324.1_21024001_3 - 0.027 15.1 0.8 0.027 15.1 0.8 1.9 2 0 0 2 2 2 0 Hox9 activation region TPR_19 PF14559.4 001309324.1_21024001_3 - 0.045 14.1 1.3 0.25 11.7 0.1 2.6 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.4 001309324.1_21024001_3 - 0.11 12.7 2.5 1.1 9.5 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat YIF1 PF03878.13 001110210.1_21023001_1 - 7.5e-84 280.8 0.9 9e-84 280.6 0.9 1.0 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.15 001110210.1_21023001_1 - 5.1e-11 42.4 7.5 5.1e-11 42.4 7.5 1.5 2 0 0 2 2 2 1 Yip1 domain DUF2070 PF09843.7 001110210.1_21023001_1 - 2.8 6.0 8.9 3.6 5.6 8.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) MIR PF02815.17 001284536.1_21022001_2 - 3.3e-12 46.5 0.2 5.1e-10 39.4 0.1 2.1 1 1 1 2 2 2 2 MIR domain MHC_II_beta PF00969.17 001142816.1_21022001_1 - 4.7e-36 122.6 1.2 8.1e-36 121.9 1.2 1.4 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001142816.1_21022001_1 - 3.7e-25 88.1 0.2 8e-25 87.0 0.1 1.7 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001142816.1_21022001_1 - 4.8e-05 23.8 0.1 0.00018 21.9 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001142816.1_21022001_1 - 0.0026 17.9 0.1 0.0048 17.1 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain MHC_I PF00129.16 001142816.1_21022001_1 - 0.0028 17.1 0.3 0.0043 16.5 0.3 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 ig PF00047.23 001142816.1_21022001_1 - 0.0045 17.0 0.1 0.011 15.7 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 001142816.1_21022001_1 - 0.022 14.7 0.2 0.058 13.3 0.2 1.8 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Ribonuc_L-PSP PF01042.19 001309285.1_21023001_1 - 3.9e-40 136.5 0.2 5.3e-40 136.1 0.2 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP IL5 PF02025.13 001082499.1_21021001_1 - 2.3e-64 214.5 0.2 2.7e-64 214.3 0.2 1.0 1 0 0 1 1 1 1 Interleukin 5 Phosducin PF02114.14 001283090.1_21022001_1 - 9.2e-18 64.0 0.1 1.1e-17 63.7 0.1 1.1 1 0 0 1 1 1 1 Phosducin UPF0175 PF03683.11 001283090.1_21022001_1 - 0.0068 16.0 3.0 0.038 13.6 0.2 2.9 1 1 2 3 3 3 1 Uncharacterised protein family (UPF0175) TraB PF01963.15 001283090.1_21022001_1 - 0.68 9.7 4.4 1 9.1 4.4 1.2 1 0 0 1 1 1 0 TraB family DUF3886 PF13025.4 001283090.1_21022001_1 - 8.4 6.5 19.4 0.72 10.0 4.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3886) Sep15_SelM PF08806.9 001170338.1_21024001_2 - 6.1e-22 77.5 0.0 1.1e-21 76.7 0.0 1.4 1 0 0 1 1 1 1 Sep15/SelM redox domain PHF5 PF03660.12 001309325.1_21022001_1 - 3.1e-49 165.4 13.9 4.5e-49 164.8 13.9 1.2 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.11 001309325.1_21022001_1 - 0.23 9.2 8.2 0.26 9.0 8.2 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 IL1 PF00340.17 001317261.1_21023001_3 - 2.5e-43 146.5 0.1 5.1e-43 145.5 0.1 1.5 1 0 0 1 1 1 1 Interleukin-1 / 18 IL1_propep PF02394.14 001317261.1_21023001_3 - 1.9e-39 134.8 0.4 3.4e-39 134.0 0.1 1.6 2 0 0 2 2 2 1 Interleukin-1 propeptide VWD PF00094.23 001242566.1_21029001_1 - 1.8e-129 427.8 10.9 1.5e-39 135.7 0.0 4.8 4 0 0 4 4 4 4 von Willebrand factor type D domain VWA PF00092.26 001242566.1_21029001_1 - 6.4e-81 270.6 0.0 2.2e-32 112.6 0.0 3.2 3 0 0 3 3 3 3 von Willebrand factor type A domain C8 PF08742.9 001242566.1_21029001_1 - 9e-54 179.7 58.3 1.5e-18 66.9 4.6 8.8 9 0 0 9 9 9 4 C8 domain VWA_N2 PF16164.3 001242566.1_21029001_1 - 1e-40 137.6 3.8 1e-40 137.6 3.8 9.6 10 1 0 10 10 10 1 VWA N-terminal TIL PF01826.15 001242566.1_21029001_1 - 2.4e-30 104.4 110.8 6.8e-13 48.5 15.8 20.5 17 4 4 22 22 22 5 Trypsin Inhibitor like cysteine rich domain VWC PF00093.16 001242566.1_21029001_1 - 4.5e-18 65.2 86.1 4.5e-09 36.4 12.7 22.2 14 5 5 19 19 19 5 von Willebrand factor type C domain Pacifastin_I PF05375.11 001242566.1_21029001_1 - 2e-05 24.1 22.0 0.00018 21.0 7.7 12.4 14 0 0 14 14 14 3 Pacifastin inhibitor (LCMII) Serum_albumin PF00273.18 001082503.1_21025001_1 - 1.2e-153 507.0 44.8 2.5e-59 199.8 9.7 3.1 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.8 001082503.1_21025001_1 - 1.8e-07 30.9 14.8 0.037 13.9 0.2 6.2 5 0 0 5 5 5 3 Vitamin D binding protein, domain III V-set PF07686.15 001284539.1_21025001_1 - 1.4e-49 166.7 14.4 2.2e-14 53.4 0.1 5.8 5 1 0 5 5 5 5 Immunoglobulin V-set domain Ig_3 PF13927.4 001284539.1_21025001_1 - 1e-15 57.9 14.2 6.8e-05 23.3 1.6 5.7 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 001284539.1_21025001_1 - 3.8e-15 55.7 8.2 0.026 14.5 1.9 6.2 5 2 0 5 5 5 5 Immunoglobulin domain I-set PF07679.14 001284539.1_21025001_1 - 1.6e-13 50.4 4.0 0.0021 17.9 0.4 5.9 5 1 0 5 5 5 3 Immunoglobulin I-set domain Ig_2 PF13895.4 001284539.1_21025001_1 - 3.3e-08 33.6 14.1 0.0091 16.2 1.3 5.9 5 2 0 5 5 5 2 Immunoglobulin domain Izumo-Ig PF16706.3 001284539.1_21025001_1 - 0.00012 21.9 0.2 4.5 7.3 0.0 4.9 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain Ta0938 PF11494.6 001284539.1_21025001_1 - 0.11 12.7 0.0 17 5.6 0.0 2.6 2 0 0 2 2 2 0 Ta0938 Lipocalin_4 PF13648.4 001284539.1_21025001_1 - 0.64 10.9 2.8 41 5.1 0.0 3.2 3 0 0 3 3 3 0 Lipocalin-like domain Adeno_E3_CR1 PF02440.13 001284539.1_21025001_1 - 1.7 8.3 7.9 0.49 10.1 1.9 2.9 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 PIP5K PF01504.16 001142399.1_21024001_2 - 5.4e-92 307.8 0.0 6.8e-92 307.4 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase YrhK PF14145.4 001142399.1_21024001_3 - 0.2 11.6 0.7 0.57 10.1 0.3 1.9 2 0 0 2 2 2 0 YrhK-like protein MHC_I PF00129.16 001123381.1_21023001_1 - 1.2e-94 314.8 0.8 1.7e-94 314.2 0.8 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001123381.1_21023001_1 - 2.9e-17 62.8 0.0 7.5e-17 61.5 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001123381.1_21023001_1 - 7.2e-12 44.9 4.3 1.3e-11 44.1 4.3 1.5 1 0 0 1 1 1 1 MHC_I C-terminus ig PF00047.23 001123381.1_21023001_1 - 0.00067 19.7 0.1 0.018 15.0 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 001123381.1_21023001_1 - 0.00092 19.1 0.0 0.0024 17.8 0.0 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 001123381.1_21023001_1 - 0.012 15.8 0.0 0.03 14.5 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain Filament PF00038.19 001243145.1_21024001_2 - 3.5e-114 381.5 52.1 4.3e-114 381.2 52.1 1.1 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.12 001243145.1_21024001_2 - 6.9e-20 71.6 22.3 6.9e-20 71.6 22.3 2.5 2 1 0 2 2 1 1 Intermediate filament head (DNA binding) region Reo_sigmaC PF04582.10 001243145.1_21024001_2 - 0.00029 20.2 8.9 0.021 14.1 0.6 3.1 1 1 2 3 3 3 2 Reovirus sigma C capsid protein DUF1664 PF07889.10 001243145.1_21024001_2 - 0.00032 20.6 21.7 0.0087 15.9 1.6 3.8 2 1 2 4 4 4 2 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.10 001243145.1_21024001_2 - 0.0046 16.9 54.7 0.2 11.6 14.4 4.1 2 1 2 4 4 4 3 TPR/MLP1/MLP2-like protein DUF4515 PF14988.4 001243145.1_21024001_2 - 0.028 14.2 45.8 0.053 13.3 32.1 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4515) MdcG PF10620.7 001243145.1_21024001_2 - 0.045 13.4 2.2 0.067 12.8 0.6 2.1 2 0 0 2 2 2 0 Phosphoribosyl-dephospho-CoA transferase MdcG Golgin_A5 PF09787.7 001243145.1_21024001_2 - 0.11 11.8 45.2 0.22 10.8 23.5 2.4 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF573 PF04504.12 001243145.1_21024001_2 - 0.15 12.6 8.6 0.75 10.4 1.0 3.2 2 2 0 2 2 2 0 Protein of unknown function, DUF573 Laminin_II PF06009.10 001243145.1_21024001_2 - 0.2 11.5 28.6 0.8 9.6 9.8 3.6 1 1 1 3 3 3 0 Laminin Domain II DUF3584 PF12128.6 001243145.1_21024001_2 - 0.21 8.9 42.9 0.65 7.3 42.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) HOOK PF05622.10 001243145.1_21024001_2 - 0.26 9.3 45.6 0.44 8.5 45.6 1.2 1 0 0 1 1 1 0 HOOK protein FPP PF05911.9 001243145.1_21024001_2 - 0.27 9.3 37.7 0.56 8.3 19.9 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil IncA PF04156.12 001243145.1_21024001_2 - 0.34 10.5 55.1 4.9 6.8 0.8 4.1 1 1 2 3 3 3 0 IncA protein bZIP_1 PF00170.19 001243145.1_21024001_2 - 0.36 10.8 29.0 6.8 6.7 1.8 5.9 4 1 1 5 5 5 0 bZIP transcription factor Jnk-SapK_ap_N PF09744.7 001243145.1_21024001_2 - 0.6 10.2 48.4 0.36 10.9 20.0 3.7 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 GAS PF13851.4 001243145.1_21024001_2 - 0.82 8.9 48.6 0.44 9.7 15.2 3.6 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Atg14 PF10186.7 001243145.1_21024001_2 - 1 8.3 29.7 2.6 6.9 14.8 2.3 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Baculo_PEP_C PF04513.10 001243145.1_21024001_2 - 1 9.2 18.6 0.96 9.3 2.0 4.3 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-F_leu_zip PF10473.7 001243145.1_21024001_2 - 1.3 9.0 45.3 0.19 11.6 9.1 3.6 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SpecificRecomb PF10136.7 001243145.1_21024001_2 - 1.7 6.7 13.4 2.2 6.3 13.4 1.2 1 0 0 1 1 1 0 Site-specific recombinase HALZ PF02183.16 001243145.1_21024001_2 - 2.7 8.2 33.3 0.12 12.5 2.4 6.3 6 1 0 6 6 6 0 Homeobox associated leucine zipper HMMR_N PF15905.3 001243145.1_21024001_2 - 3.1 7.0 43.0 0.045 13.1 10.7 2.7 1 1 2 3 3 3 0 Hyaluronan mediated motility receptor N-terminal Rab5-bind PF09311.9 001243145.1_21024001_2 - 9.3 5.4 46.7 0.61 9.3 12.6 2.9 2 1 0 2 2 2 0 Rabaptin-like protein FAD_binding_1 PF00667.18 001122655.1_21025001_1 - 1.4e-82 276.5 0.0 2e-82 276.0 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 001122655.1_21025001_1 - 1.8e-39 135.1 0.9 4.6e-39 133.8 0.5 2.0 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.19 001122655.1_21025001_1 - 6.6e-18 65.2 0.1 2.4e-17 63.4 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain LRR_8 PF13855.4 001309339.1_21023001_3 - 3.3e-24 84.3 41.5 9e-09 34.8 7.2 3.9 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 001309339.1_21023001_3 - 4.6e-19 68.0 24.4 9.1e-06 25.8 1.6 4.7 2 2 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001309339.1_21023001_3 - 8.6e-08 31.5 19.6 3.3 8.4 0.2 7.7 7 0 0 7 7 7 5 Leucine Rich Repeat LRR_6 PF13516.4 001309339.1_21023001_3 - 2.6e-05 23.8 23.7 5.8 7.1 0.4 7.4 7 0 0 7 7 7 5 Leucine Rich repeat Ferritin PF00210.22 001252054.1_21022001_3 - 3.9e-39 133.7 6.0 4.8e-39 133.4 6.0 1.1 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.15 001252054.1_21022001_3 - 0.0059 16.9 0.6 0.0086 16.3 0.6 1.4 1 0 0 1 1 1 1 Rubrerythrin MFS_1 PF07690.14 001145532.1_21024001_3 - 2.1e-34 118.9 50.7 3.4e-32 111.6 34.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily V-ATPase_C PF03223.13 001309283.1_21024001_3 - 2e-165 550.5 7.4 2.3e-165 550.3 7.4 1.0 1 0 0 1 1 1 1 V-ATPase subunit C DUF4300 PF14133.4 001309283.1_21024001_3 - 0.043 13.4 0.2 0.043 13.4 0.2 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4300) ASXH PF13919.4 001309283.1_21024001_3 - 0.11 12.4 0.5 0.22 11.4 0.5 1.5 1 0 0 1 1 1 0 Asx homology domain GST_C_3 PF14497.4 001284532.1_21022001_1 - 3.7e-21 75.0 0.0 6.2e-21 74.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 001284532.1_21022001_1 - 4e-21 74.9 0.0 6.7e-21 74.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 001284532.1_21022001_1 - 2.3e-19 69.4 0.0 9.8e-19 67.4 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.4 001284532.1_21022001_1 - 0.0092 16.2 0.0 0.026 14.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 001284532.1_21022001_1 - 0.041 13.7 0.0 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain DUF3336 PF11815.6 001284532.1_21022001_1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3336) Glyco_hydro_106 PF17132.2 001284532.1_21022001_2 - 0.031 12.4 0.1 0.041 12.0 0.1 1.0 1 0 0 1 1 1 0 alpha-L-rhamnosidase polyprenyl_synt PF00348.15 001309326.1_21023001_2 - 2.9e-93 311.5 0.0 3.6e-93 311.2 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Arf PF00025.19 001309268.1_21023001_2 - 5.7e-66 221.2 0.0 7e-66 220.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 001309268.1_21023001_2 - 7.8e-17 61.2 0.0 1e-16 60.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001309268.1_21023001_2 - 1.5e-16 60.5 0.1 2.1e-16 60.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 001309268.1_21023001_2 - 1.4e-11 44.0 0.0 2.6e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 001309268.1_21023001_2 - 3e-07 30.4 0.1 4.1e-07 29.9 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.18 001309268.1_21023001_2 - 7.5e-07 28.5 0.3 1.2e-05 24.5 0.1 2.1 1 1 1 2 2 2 1 G-protein alpha subunit GTP_EFTU PF00009.25 001309268.1_21023001_2 - 0.00053 19.4 0.1 0.0013 18.2 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001309268.1_21023001_2 - 0.00088 18.6 0.0 0.0013 18.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.15 001309268.1_21023001_2 - 0.042 13.5 0.0 0.083 12.5 0.0 1.4 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein 6PF2K PF01591.16 001309268.1_21023001_2 - 0.059 12.5 0.0 0.09 11.9 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase DUF258 PF03193.14 001309268.1_21023001_2 - 0.15 11.8 0.3 0.97 9.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_28 PF13521.4 001309268.1_21023001_2 - 0.19 11.8 0.1 0.94 9.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain Sel1 PF08238.10 001317264.1_21026001_2 - 7.1e-59 194.8 41.7 2.6e-08 34.1 0.9 12.9 13 0 0 13 13 13 11 Sel1 repeat fn2 PF00040.17 001317264.1_21026001_2 - 1.4e-17 63.5 6.3 2.6e-17 62.7 6.3 1.5 1 0 0 1 1 1 1 Fibronectin type II domain TPR_6 PF13174.4 001317264.1_21026001_2 - 1 10.0 17.7 23 5.8 0.1 7.2 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_1 PF00515.26 001317264.1_21026001_2 - 8.7 6.2 19.5 2.5 7.9 0.6 7.4 7 0 0 7 7 7 0 Tetratricopeptide repeat TNF PF00229.16 001297473.1_21022001_1 - 1e-44 151.4 0.3 1.6e-44 150.8 0.3 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Thermopsin PF05317.9 001297473.1_21022001_1 - 0.0045 16.4 0.2 0.0071 15.7 0.2 1.2 1 0 0 1 1 1 1 Thermopsin C1q PF00386.19 001297473.1_21022001_1 - 0.072 13.2 1.8 1.3 9.1 1.8 2.3 1 1 0 1 1 1 0 C1q domain Cadherin PF00028.15 001143950.1_21026001_1 - 2.9e-78 258.3 2.9 5.3e-19 68.3 0.0 5.4 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.15 001143950.1_21026001_1 - 1.3e-55 187.1 0.1 2.2e-55 186.4 0.1 1.4 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.3 001143950.1_21026001_1 - 5.6e-07 29.4 4.1 2.1 8.3 0.0 5.6 6 0 0 6 6 6 2 Cadherin-like Cadherin_2 PF08266.10 001143950.1_21026001_1 - 0.0017 18.0 0.0 6 6.6 0.0 3.7 4 0 0 4 4 4 2 Cadherin-like Cadherin_pro PF08758.9 001143950.1_21026001_1 - 0.0026 17.7 0.0 3.6 7.7 0.0 3.5 3 0 0 3 3 3 1 Cadherin prodomain like ASFV_J13L PF05568.9 001143950.1_21026001_1 - 0.024 14.3 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein Rifin_STEVOR PF02009.14 001143950.1_21026001_1 - 0.027 14.2 0.1 0.041 13.6 0.1 1.2 1 0 0 1 1 1 0 Rifin/stevor family MHC_I_3 PF16497.3 001246676.1_21023001_1 - 1.7e-74 249.5 0.0 2.1e-74 249.2 0.0 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001246676.1_21023001_1 - 1.3e-10 41.5 0.0 3.1e-10 40.3 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001246676.1_21023001_1 - 5.3e-05 22.7 0.0 0.00012 21.5 0.0 1.5 1 1 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_3 PF13927.4 001246676.1_21023001_1 - 0.19 12.2 0.1 1.2 9.7 0.0 2.0 1 1 1 2 2 2 0 Immunoglobulin domain DUF4381 PF14316.4 001246676.1_21023001_1 - 6.4 6.9 6.0 28 4.8 3.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) GST_N PF02798.18 001283076.1_21022001_1 - 2.3e-20 72.6 0.0 5e-20 71.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001283076.1_21022001_1 - 7.3e-19 67.7 0.0 1.2e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 001283076.1_21022001_1 - 1.8e-18 66.4 0.0 2.9e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001283076.1_21022001_1 - 0.0079 16.4 0.0 0.016 15.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 001283076.1_21022001_1 - 0.088 12.6 0.0 0.44 10.4 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain 7tm_1 PF00001.19 001164013.1_21025001_1 - 1.2e-31 109.9 23.3 1.8e-31 109.2 23.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GnHR_trans PF12369.6 001164013.1_21025001_1 - 1.2e-22 80.3 0.9 2.3e-22 79.4 0.9 1.5 1 0 0 1 1 1 1 Gonadotropin hormone receptor transmembrane region LRR_8 PF13855.4 001164013.1_21025001_1 - 7.7e-22 76.7 13.1 1e-06 28.3 0.0 5.3 2 2 3 5 5 5 5 Leucine rich repeat LRR_5 PF13306.4 001164013.1_21025001_1 - 9.3e-14 51.4 0.5 2.7e-07 30.4 0.0 2.4 1 1 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001164013.1_21025001_1 - 9.7e-06 25.7 21.8 0.41 11.0 0.2 4.8 3 1 0 4 4 4 4 Leucine Rich repeats (2 copies) LRRNT PF01462.16 001164013.1_21025001_1 - 4.8e-05 22.8 0.5 4.8e-05 22.8 0.5 2.6 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 001164013.1_21025001_1 - 0.018 14.5 2.9 0.033 13.5 1.5 1.9 1 1 0 2 2 2 0 Leucine-rich repeat LRR_1 PF00560.31 001164013.1_21025001_1 - 8.3 7.2 11.2 36 5.3 0.2 5.8 5 1 1 6 6 6 0 Leucine Rich Repeat Furin-like_2 PF15913.3 001109681.1_21022001_1 - 6.1e-48 161.3 25.5 6.1e-48 161.3 25.5 1.9 2 0 0 2 2 2 1 Furin-like repeat, cysteine-rich VSP PF03302.11 001109681.1_21022001_1 - 0.0015 17.4 12.9 0.0015 17.4 12.9 2.0 1 1 1 2 2 2 2 Giardia variant-specific surface protein Arf PF00025.19 001309322.1_21022001_2 - 5e-77 257.2 0.0 6.2e-77 256.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 001309322.1_21022001_2 - 4.1e-14 52.7 0.0 5.8e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001309322.1_21022001_2 - 2.6e-13 49.8 0.0 3.2e-13 49.5 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 001309322.1_21022001_2 - 2.6e-10 39.9 0.5 2.1e-06 27.0 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.8 001309322.1_21022001_2 - 3.8e-10 39.3 0.0 4.7e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.10 001309322.1_21022001_2 - 2.4e-09 36.8 0.0 3.1e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001309322.1_21022001_2 - 8.6e-05 22.5 0.0 0.00015 21.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001309322.1_21022001_2 - 0.0025 17.2 0.1 0.015 14.7 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ArgK PF03308.14 001309322.1_21022001_2 - 0.008 15.0 0.3 0.18 10.6 0.0 2.3 2 1 0 2 2 2 1 ArgK protein ABC_tran PF00005.25 001309322.1_21022001_2 - 0.025 15.0 0.1 0.48 10.8 0.0 2.0 2 0 0 2 2 2 0 ABC transporter AAA_18 PF13238.4 001309322.1_21022001_2 - 0.043 14.2 0.0 0.06 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.16 001309322.1_21022001_2 - 0.086 12.2 0.5 0.41 10.0 0.5 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B DUF258 PF03193.14 001309322.1_21022001_2 - 0.13 12.0 0.1 16 5.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Prp18 PF02840.13 001309307.1_21025001_1 - 1.3e-62 210.0 0.2 2.3e-62 209.2 0.2 1.4 1 0 0 1 1 1 1 Prp18 domain PRP4 PF08799.9 001309307.1_21025001_1 - 2.7e-13 49.0 3.5 2.7e-13 49.0 3.5 2.3 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like Rrp15p PF07890.10 001309302.1_21024001_2 - 1.1e-32 113.0 13.3 1.1e-32 113.0 13.3 2.1 2 0 0 2 2 2 1 Rrp15p MctB PF11382.6 001309302.1_21024001_2 - 0.00091 18.9 0.4 0.0017 18.0 0.4 1.4 1 0 0 1 1 1 1 Copper transport outer membrane protein, MctB Josephin PF02099.15 001286863.1_21024001_2 - 1.8e-54 184.0 0.9 2.9e-54 183.4 0.0 1.8 2 0 0 2 2 2 1 Josephin SUIM_assoc PF16619.3 001286863.1_21024001_2 - 1.1e-34 118.2 11.9 2.4e-34 117.1 11.9 1.6 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 UIM PF02809.18 001286863.1_21024001_2 - 5.8e-10 38.3 28.8 8.3e-05 22.1 0.8 4.7 5 0 0 5 5 5 3 Ubiquitin interaction motif Arrestin_N PF00339.27 001286863.1_21024001_2 - 0.094 12.7 0.2 0.16 11.9 0.2 1.3 1 0 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain Metallophos PF00149.26 001246672.1_21023001_2 - 8.9e-22 78.5 0.0 1.2e-21 78.0 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PhoD PF09423.8 001246672.1_21023001_2 - 0.0085 15.0 0.0 0.24 10.2 0.0 2.1 2 0 0 2 2 2 2 PhoD-like phosphatase PET PF06297.12 001114149.1_21026001_1 - 3.5e-41 139.2 3.1 6.7e-41 138.4 3.1 1.5 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 001114149.1_21026001_1 - 2.8e-26 91.4 63.3 8e-14 51.5 8.1 4.8 5 1 0 5 5 5 3 LIM domain Ig_Tie2_1 PF10430.7 001114149.1_21026001_1 - 0.068 13.5 0.0 0.29 11.4 0.0 2.1 1 0 0 1 1 1 0 Tie-2 Ig-like domain 1 DUF4234 PF14018.4 001114149.1_21026001_1 - 0.19 11.8 2.8 0.54 10.3 2.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4234) WD40 PF00400.30 001309340.1_21023001_3 - 2e-12 47.2 2.4 7.4e-05 23.3 0.0 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001309340.1_21023001_3 - 0.0054 16.9 0.1 0.24 11.6 0.0 2.8 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Phage_gp49_66 PF13876.4 001309340.1_21023001_3 - 0.018 15.2 0.0 0.056 13.6 0.0 1.9 2 0 0 2 2 2 0 Phage protein (N4 Gp49/phage Sf6 gene 66) family RRM_1 PF00076.20 001195548.1_21027001_3 - 4.9e-32 109.4 0.0 2.5e-16 59.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 001195548.1_21027001_3 - 0.0013 18.5 0.0 0.011 15.5 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.3 001195548.1_21027001_3 - 0.0042 16.8 0.0 0.008 15.9 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.9 001195548.1_21027001_3 - 0.036 14.0 0.0 0.9 9.5 0.0 2.1 2 0 0 2 2 2 0 RNA binding motif Corona_nucleoca PF00937.16 001195548.1_21027001_3 - 0.042 12.7 6.8 0.06 12.2 6.8 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein RRM_7 PF16367.3 001195548.1_21027001_3 - 0.053 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif PRP38_assoc PF12871.5 001195548.1_21027001_3 - 8.7 6.8 28.0 17 5.9 28.0 1.4 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Caveolin PF01146.15 001114144.1_21026001_1 - 2.9e-55 185.7 2.4 3.3e-55 185.6 1.2 1.7 2 0 0 2 2 2 1 Caveolin RRM_1 PF00076.20 001195587.1_21023001_2 - 3.4e-30 103.5 0.1 4.2e-16 58.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 001195587.1_21023001_2 - 9.1e-06 25.5 0.1 0.012 15.5 0.0 2.3 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.4 001195587.1_21023001_2 - 4.8e-05 23.1 0.0 0.00041 20.1 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.3 001195587.1_21023001_2 - 0.038 13.7 0.0 8.6 6.2 0.0 2.2 2 0 0 2 2 2 0 Occluded RNA-recognition motif Presenilin PF01080.15 001195587.1_21023001_2 - 0.083 11.5 3.0 0.11 11.1 3.0 1.1 1 0 0 1 1 1 0 Presenilin DbpA PF03880.13 001195587.1_21023001_2 - 0.089 12.7 0.1 22 5.0 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain ALMT PF11744.6 001195587.1_21023001_2 - 4 6.0 5.3 5.7 5.5 5.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4551 PF15087.4 001195587.1_21023001_2 - 7.7 5.1 15.2 11 4.6 15.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) F-actin_cap_A PF01267.15 001114142.1_21025001_1 - 6.4e-106 353.5 1.6 7.9e-106 353.2 1.6 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit Transposase_1 PF01359.16 001309342.1_21024001_1 - 0.0013 18.4 0.9 0.0024 17.6 0.3 1.7 2 0 0 2 2 2 1 Transposase (partial DDE domain) D123 PF07065.12 001309342.1_21024001_3 - 1e-104 349.9 0.4 1.2e-104 349.7 0.4 1.0 1 0 0 1 1 1 1 D123 DUF4343 PF14243.4 001309342.1_21024001_3 - 0.0023 18.0 0.0 0.0039 17.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4343) Reg_prop PF07494.9 001309342.1_21024001_3 - 0.17 12.1 0.1 0.54 10.5 0.1 1.9 1 0 0 1 1 1 0 Two component regulator propeller Ank_2 PF12796.5 001114141.1_21024001_2 - 8.2e-40 135.2 1.5 3.8e-15 56.1 0.2 3.9 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001114141.1_21024001_2 - 1.3e-23 82.6 0.1 1.7e-10 40.8 0.0 5.0 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 001114141.1_21024001_2 - 1.8e-22 79.3 0.0 7.1e-11 42.3 0.0 3.8 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.28 001114141.1_21024001_2 - 8.9e-22 76.4 1.0 4.4e-06 26.8 0.0 5.8 6 1 1 7 7 7 4 Ankyrin repeat Ank_3 PF13606.4 001114141.1_21024001_2 - 2.7e-20 70.1 0.1 0.00051 20.2 0.0 5.9 5 0 0 5 5 5 4 Ankyrin repeat SAM_2 PF07647.15 001114141.1_21024001_2 - 2.2e-07 30.8 0.3 4.7e-07 29.7 0.3 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001114141.1_21024001_2 - 2.1e-06 28.0 0.4 4.4e-06 26.9 0.4 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) ATG16 PF08614.9 001114141.1_21024001_2 - 0.07 13.2 0.1 0.28 11.2 0.0 1.9 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) CortBP2 PF09727.7 001114145.1_21029001_3 - 1.3e-40 139.2 40.7 5.3e-34 117.7 1.3 3.3 2 1 1 3 3 3 3 Cortactin-binding protein-2 Ank_2 PF12796.5 001114145.1_21029001_3 - 8.4e-38 128.7 6.4 6.1e-18 65.1 3.4 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001114145.1_21029001_3 - 1e-34 118.3 4.5 7.2e-13 48.6 0.3 5.0 2 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.4 001114145.1_21029001_3 - 4.4e-25 87.2 6.5 2.3e-09 37.2 0.0 5.8 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.28 001114145.1_21029001_3 - 4.6e-23 80.5 6.7 2e-05 24.7 0.0 6.2 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.4 001114145.1_21029001_3 - 6.3e-19 66.0 4.1 0.0023 18.2 0.0 7.3 7 0 0 7 7 7 5 Ankyrin repeat DUF812 PF05667.9 001114145.1_21029001_3 - 0.027 13.3 26.3 0.061 12.1 26.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF812) CALCOCO1 PF07888.9 001114145.1_21029001_3 - 0.083 11.3 27.5 0.14 10.5 27.5 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.9 001114145.1_21029001_3 - 7.9 5.1 33.0 15 4.2 33.0 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3584 PF12128.6 001114145.1_21029001_3 - 8.7 3.6 26.7 13 3.0 26.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MitoNEET_N PF10660.7 001309347.1_21023001_2 - 5.5e-09 35.8 0.1 1.1e-08 34.8 0.1 1.5 1 0 0 1 1 1 1 Iron-containing outer mitochondrial membrane protein N-terminus zf-CDGSH PF09360.8 001309347.1_21023001_2 - 7.7e-09 35.5 0.3 7.7e-09 35.5 0.3 2.0 2 0 0 2 2 2 1 Iron-binding zinc finger CDGSH type Sec23_trunk PF04811.13 001309205.1_21029001_1 - 5.4e-90 301.1 0.0 7.3e-90 300.6 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.13 001309205.1_21029001_1 - 4.2e-27 93.8 0.1 8e-27 92.9 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.10 001309205.1_21029001_1 - 1.7e-17 63.8 0.0 8.4e-17 61.6 0.0 2.1 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.13 001309205.1_21029001_1 - 7.7e-14 51.3 12.2 1.8e-13 50.1 12.2 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.20 001309205.1_21029001_1 - 1.1e-11 44.4 0.0 2.4e-11 43.2 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat VWA_2 PF13519.4 001142400.1_21023001_3 - 2.6e-24 85.8 1.1 1.2e-23 83.6 0.0 2.6 4 1 0 4 4 4 1 von Willebrand factor type A domain VWA PF00092.26 001142400.1_21023001_3 - 2.1e-07 31.2 0.1 6.9e-07 29.6 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain Ssl1 PF04056.12 001142400.1_21023001_3 - 6e-07 29.3 0.1 1e-06 28.6 0.1 1.3 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.18 001142400.1_21023001_3 - 7e-07 28.6 10.0 0.00014 21.4 0.4 3.3 3 0 0 3 3 3 2 Ubiquitin interaction motif IL8 PF00048.18 001143955.1_21021001_1 - 6.1e-16 58.2 1.1 7.8e-16 57.9 1.1 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like RRM_1 PF00076.20 001253840.1_21022001_2 - 1.2e-25 88.9 0.3 8.3e-14 51.0 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001253840.1_21022001_2 - 2.5e-07 30.2 0.1 0.0072 15.8 0.2 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001253840.1_21022001_2 - 7e-07 28.9 0.0 0.0059 16.3 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif SPT_ssu-like PF11779.6 001253840.1_21022001_3 - 2.3 7.8 9.0 2.5 7.6 2.0 3.2 3 0 0 3 3 3 0 Small subunit of serine palmitoyltransferase-like CBS PF00571.26 001163984.1_21024001_1 - 1.3e-30 105.5 5.5 2.2e-08 34.3 0.1 4.5 4 0 0 4 4 4 4 CBS domain TGFb_propeptide PF00688.16 001081817.1_21023001_1 - 9.6e-32 110.5 0.0 1.4e-31 110.0 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001081817.1_21023001_1 - 5.2e-28 97.9 2.4 6e-28 97.7 1.1 1.8 2 0 0 2 2 2 1 Transforming growth factor beta like domain Gasdermin PF04598.10 001081889.1_21025001_3 - 7.8e-162 539.3 0.4 9e-162 539.1 0.4 1.0 1 0 0 1 1 1 1 Gasdermin family p450 PF00067.20 001163957.1_21024001_1 - 2.9e-92 309.7 0.0 3.4e-92 309.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 I-set PF07679.14 001101650.1_21025001_3 - 3.5e-57 190.3 0.9 4.3e-14 52.2 0.0 5.9 5 0 0 5 5 5 5 Immunoglobulin I-set domain C2-set PF05790.13 001101650.1_21025001_3 - 4.1e-55 183.8 16.4 4.7e-27 93.9 0.7 6.4 6 1 0 6 6 6 2 Immunoglobulin C2-set domain Ig_3 PF13927.4 001101650.1_21025001_3 - 4.5e-54 180.8 10.1 3.3e-10 40.3 0.1 7.3 7 0 0 7 7 7 5 Immunoglobulin domain ig PF00047.23 001101650.1_21025001_3 - 7.7e-46 154.1 14.0 5.3e-11 42.4 0.0 7.1 7 1 0 7 7 7 5 Immunoglobulin domain Ig_2 PF13895.4 001101650.1_21025001_3 - 6.6e-40 135.2 6.4 2.9e-09 37.0 0.0 7.1 7 0 0 7 7 7 5 Immunoglobulin domain V-set PF07686.15 001101650.1_21025001_3 - 1.4e-19 70.1 14.7 0.046 13.7 0.0 10.6 7 5 4 11 11 11 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 001101650.1_21025001_3 - 1.2e-17 63.6 7.8 0.024 14.6 0.0 7.0 6 1 0 6 6 6 5 CD80-like C2-set immunoglobulin domain ICAM_N PF03921.12 001101650.1_21025001_3 - 5.9e-14 51.4 5.8 0.0019 17.7 0.0 4.7 4 0 0 4 4 4 4 Intercellular adhesion molecule (ICAM), N-terminal domain Ig_5 PF16681.3 001101650.1_21025001_3 - 2.8e-13 49.9 3.8 0.0049 17.1 0.0 5.4 5 0 0 5 5 5 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 001101650.1_21025001_3 - 1.6e-10 40.7 0.2 0.26 11.2 0.0 5.4 5 0 0 5 5 5 2 Izumo-like Immunoglobulin domain Ig_4 PF16680.3 001101650.1_21025001_3 - 4.9e-10 39.5 7.4 0.04 14.2 0.0 5.7 7 0 0 7 7 7 3 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.13 001101650.1_21025001_3 - 5.7e-08 33.0 4.8 0.034 14.5 0.0 5.9 7 1 0 7 7 5 2 Immunoglobulin C1-set domain Receptor_2B4 PF11465.6 001101650.1_21025001_3 - 1.3e-05 25.2 0.2 0.11 12.6 0.0 3.8 3 0 0 3 3 3 1 Natural killer cell receptor 2B4 Lep_receptor_Ig PF06328.9 001101650.1_21025001_3 - 0.00021 21.1 7.2 0.3 11.0 0.4 6.0 6 0 0 6 6 6 1 Ig-like C2-type domain Adeno_E3_CR1 PF02440.13 001101650.1_21025001_3 - 0.004 16.8 0.9 5.8 6.6 0.0 4.2 5 0 0 5 5 4 1 Adenovirus E3 region protein CR1 INCA1 PF15142.4 001101650.1_21025001_3 - 0.029 14.2 0.0 3 7.7 0.0 2.3 2 0 0 2 2 2 0 INCA1 CAP_GLY PF01302.23 001309331.1_21024001_1 - 2.2e-19 69.1 0.9 4e-19 68.3 0.9 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.5 001309331.1_21024001_1 - 5.7e-16 58.2 14.0 0.0002 21.5 0.3 5.3 5 0 0 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001309331.1_21024001_1 - 4.8e-12 45.6 0.5 1.9e-10 40.4 0.1 2.5 1 1 0 2 2 2 1 Leucine-rich repeat Ubiquitin_2 PF14560.4 001309331.1_21024001_1 - 9.4e-06 25.9 0.1 1.9e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain LRR_8 PF13855.4 001309331.1_21024001_1 - 2.4e-05 23.9 19.7 0.01 15.5 1.7 5.1 3 1 3 6 6 6 5 Leucine rich repeat LRR_6 PF13516.4 001309331.1_21024001_1 - 0.003 17.4 10.2 14 5.9 0.0 6.2 6 0 0 6 6 6 2 Leucine Rich repeat ubiquitin PF00240.21 001309331.1_21024001_1 - 0.03 13.9 0.4 0.26 10.9 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin family LRR_1 PF00560.31 001309331.1_21024001_1 - 2.2 9.0 13.0 60 4.6 0.1 6.1 6 1 0 6 6 6 0 Leucine Rich Repeat VEGF_C PF14554.4 001081821.1_21022001_1 - 3e-28 97.6 20.4 3e-28 97.6 20.4 2.2 2 1 1 3 3 3 1 VEGF heparin-binding domain PDGF PF00341.15 001081821.1_21022001_1 - 4.6e-27 94.0 4.8 4.6e-27 94.0 4.8 2.4 2 1 0 2 2 2 1 PDGF/VEGF domain CXCXC PF03128.12 001081821.1_21022001_1 - 4 8.0 20.3 0.9 10.0 0.8 3.7 3 0 0 3 3 3 0 CXCXC repeat zf-H2C2_2 PF13465.4 001308311.1_21029001_2 - 7.5e-17 60.8 32.0 2.8e-07 30.6 2.8 6.2 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2 PF00096.24 001308311.1_21029001_2 - 4.3e-12 45.7 44.9 0.00025 21.2 1.3 7.2 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001308311.1_21029001_2 - 3.4e-08 33.5 41.4 0.0032 18.0 1.1 7.3 6 0 0 6 6 6 3 C2H2-type zinc finger zf-H2C2_5 PF13909.4 001308311.1_21029001_2 - 0.001 18.6 0.9 0.001 18.6 0.9 5.0 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 001308311.1_21029001_2 - 0.014 15.6 13.6 1.7 8.9 0.0 5.1 3 1 1 4 4 4 0 Zinc-finger double-stranded RNA-binding GAGA PF09237.9 001308311.1_21029001_2 - 0.11 12.2 2.6 0.5 10.1 0.1 2.7 1 1 1 2 2 2 0 GAGA factor zf-C2H2_11 PF16622.3 001308311.1_21029001_2 - 2.4 7.9 12.5 0.36 10.5 0.3 3.9 3 0 0 3 3 3 0 zinc-finger C2H2-type Pyr_redox_2 PF07992.12 001301150.1_21026001_1 - 1.7e-66 224.3 6.2 1.7e-66 224.3 6.2 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 001301150.1_21026001_1 - 6.9e-42 142.0 0.4 1.7e-41 140.7 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 001301150.1_21026001_1 - 1.3e-16 60.8 8.0 7.8e-16 58.3 1.4 2.8 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.5 001301150.1_21026001_1 - 7.3e-09 35.3 0.1 7.3e-09 35.3 0.1 2.4 2 1 1 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.4 001301150.1_21026001_1 - 6.9e-08 32.0 2.9 4.7e-05 22.6 0.1 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 001301150.1_21026001_1 - 4.2e-07 30.0 2.4 0.00014 21.9 0.1 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.22 001301150.1_21026001_1 - 1.1e-06 27.9 7.8 1.6e-06 27.3 0.3 2.6 3 0 0 3 3 2 1 FAD binding domain GIDA PF01134.20 001301150.1_21026001_1 - 8.3e-06 25.0 2.8 8.3e-06 25.0 2.8 2.5 2 1 0 2 2 2 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.19 001301150.1_21026001_1 - 9.5e-05 21.7 4.2 0.053 12.7 0.5 2.6 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.4 001301150.1_21026001_1 - 0.0004 19.5 0.4 0.4 9.6 0.3 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.12 001301150.1_21026001_1 - 0.00053 18.7 9.2 0.0028 16.3 0.5 3.1 4 0 0 4 4 4 2 HI0933-like protein FAD_binding_3 PF01494.17 001301150.1_21026001_1 - 0.0015 17.8 4.9 0.021 14.0 0.2 3.1 3 0 0 3 3 3 1 FAD binding domain Thi4 PF01946.15 001301150.1_21026001_1 - 0.0033 16.6 0.0 0.0082 15.3 0.0 1.6 1 0 0 1 1 1 1 Thi4 family UDPG_MGDP_dh_N PF03721.12 001301150.1_21026001_1 - 0.25 10.8 5.6 2.2 7.7 0.2 2.9 3 0 0 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Mqo PF06039.13 001301150.1_21026001_1 - 0.25 9.7 1.2 2 6.7 0.0 2.0 1 1 1 2 2 2 0 Malate:quinone oxidoreductase (Mqo) 3HCDH_N PF02737.16 001301150.1_21026001_1 - 0.53 10.0 4.3 3.2 7.5 0.6 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.22 001301150.1_21026001_1 - 3.8 6.9 11.2 6.5 6.1 0.4 3.7 3 1 0 4 4 4 0 FAD dependent oxidoreductase TGFb_propeptide PF00688.16 001195158.1_21023001_1 - 9.7e-95 316.8 0.1 1.5e-94 316.3 0.1 1.3 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001195158.1_21023001_1 - 1.6e-36 125.2 0.7 3.7e-36 124.1 0.7 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain Proteasome PF00227.24 001283074.1_21022001_2 - 4.1e-51 173.0 0.1 6.3e-51 172.4 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 001283074.1_21022001_2 - 3.7e-14 51.9 0.1 6.2e-14 51.2 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF5018 PF16410.3 001283074.1_21022001_2 - 0.00081 18.1 0.0 0.28 9.7 0.0 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF5018) Sulfotransfer_1 PF00685.25 001081918.1_21023001_3 - 2.4e-91 305.8 1.2 2.9e-91 305.5 1.2 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001081918.1_21023001_3 - 0.00072 19.9 0.0 0.17 12.1 0.0 2.2 2 0 0 2 2 2 2 Sulfotransferase family Ldh_1_N PF00056.21 001145111.1_21023001_2 - 6.6e-50 168.7 0.9 1e-49 168.1 0.9 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 001145111.1_21023001_2 - 3.8e-23 82.1 0.0 6.7e-23 81.3 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.14 001145111.1_21023001_2 - 0.0013 18.2 0.0 0.0041 16.6 0.0 1.8 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase Ly49 PF08391.8 001081828.1_21023001_2 - 4.9e-48 162.3 8.5 6.8e-48 161.8 8.5 1.2 1 0 0 1 1 1 1 Ly49-like protein, N-terminal region Lectin_C PF00059.19 001081828.1_21023001_2 - 4.1e-15 56.3 3.1 7.5e-15 55.5 3.1 1.4 1 0 0 1 1 1 1 Lectin C-type domain Tetraspannin PF00335.18 001081828.1_21023001_2 - 0.076 12.7 1.4 0.12 12.0 1.4 1.3 1 0 0 1 1 1 0 Tetraspanin family Na_H_Exchanger PF00999.19 001163960.1_21025001_1 - 1.9e-93 313.2 43.8 2.3e-93 312.9 43.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.3 001163960.1_21025001_1 - 1.5e-41 141.1 10.2 2.4e-41 140.4 10.2 1.3 1 0 0 1 1 1 1 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Ribosomal_S30 PF04758.12 001163865.1_21022001_2 - 1.9e-30 104.7 12.9 1.9e-30 104.7 12.9 2.0 2 0 0 2 2 2 1 Ribosomal protein S30 ubiquitin PF00240.21 001163865.1_21022001_2 - 9.2e-14 50.8 0.0 1.3e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 001163865.1_21022001_2 - 0.0011 18.6 0.0 0.002 17.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ribosomal_60s PF00428.17 001085436.1_21021001_1 - 2.5e-26 91.9 7.4 3.2e-26 91.6 7.4 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Cyt-b5 PF00173.26 001159732.1_21022001_1 - 1.9e-22 79.0 0.1 2.6e-22 78.6 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Ly49 PF08391.8 001081829.2_21023001_2 - 1.3e-49 167.3 7.7 2e-49 166.7 7.7 1.3 1 0 0 1 1 1 1 Ly49-like protein, N-terminal region Lectin_C PF00059.19 001081829.2_21023001_2 - 1.3e-14 54.7 3.6 2.6e-14 53.7 3.6 1.6 1 0 0 1 1 1 1 Lectin C-type domain TMEM154 PF15102.4 001081829.2_21023001_2 - 0.0076 16.0 0.1 0.012 15.3 0.1 1.3 1 0 0 1 1 1 1 TMEM154 protein family Cadherin_C_2 PF16492.3 001081829.2_21023001_2 - 0.062 14.0 1.2 0.13 12.9 1.2 1.7 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal SIT PF15330.4 001081829.2_21023001_2 - 0.091 13.0 2.1 0.14 12.4 0.9 1.8 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT UL45 PF05473.10 001081829.2_21023001_2 - 0.3 10.6 0.0 0.3 10.6 0.0 2.1 2 1 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like EphA2_TM PF14575.4 001081829.2_21023001_2 - 2 9.2 5.0 19 6.0 5.0 2.3 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Stig1 PF04885.11 001081829.2_21023001_2 - 2.5 8.4 13.0 0.081 13.3 6.4 1.8 2 0 0 2 2 2 0 Stigma-specific protein, Stig1 Ribosomal_S26e PF01283.17 001163890.1_21021001_3 - 1.4e-54 182.9 7.3 1.9e-54 182.6 7.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S26e Fer4_7 PF12838.5 001163890.1_21021001_3 - 0.006 17.0 0.8 0.068 13.6 0.4 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Armet PF10208.7 001197315.1_21022001_3 - 2.3e-69 231.8 8.3 2.9e-69 231.5 8.3 1.1 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding CheZ PF04344.11 001197315.1_21022001_3 - 0.041 13.7 0.0 0.05 13.4 0.0 1.2 1 0 0 1 1 1 0 Chemotaxis phosphatase, CheZ Epsilon_antitox PF08998.9 001197315.1_21022001_3 - 0.079 13.1 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial epsilon antitoxin DIM1 PF02966.14 001253841.1_21022001_2 - 1.4e-69 231.8 0.2 1.8e-69 231.5 0.2 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.18 001253841.1_21022001_2 - 1.1e-05 25.2 0.1 1.6e-05 24.6 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.4 001253841.1_21022001_2 - 0.034 14.3 0.2 0.061 13.5 0.2 1.4 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_7 PF13899.4 001253841.1_21022001_2 - 0.13 12.3 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like S1 PF00575.21 001309513.1_21029001_2 - 5e-69 228.5 5.2 3.6e-11 43.1 0.0 13.8 15 0 0 15 15 14 8 S1 RNA binding domain Suf PF05843.12 001309513.1_21029001_2 - 3.9e-11 43.3 1.0 3.9e-11 43.3 1.0 4.2 4 1 0 5 5 4 2 Suppressor of forked protein (Suf) TPR_14 PF13428.4 001309513.1_21029001_2 - 4.3e-08 33.2 2.8 0.27 12.0 0.0 4.9 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.4 001309513.1_21029001_2 - 5.1e-07 30.0 0.1 0.76 10.2 0.0 3.8 2 2 1 4 4 4 4 Tetratricopeptide repeat TPR_15 PF13429.4 001309513.1_21029001_2 - 0.00013 21.2 5.0 0.063 12.3 0.2 3.2 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.4 001309513.1_21029001_2 - 0.00083 19.9 0.2 2.1 9.0 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.4 001309513.1_21029001_2 - 0.0066 16.4 1.2 8 6.8 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.4 001309513.1_21029001_2 - 0.026 14.4 0.1 0.26 11.3 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.4 001309513.1_21029001_2 - 0.032 14.7 4.6 0.31 11.6 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2110 PF09883.7 001309513.1_21029001_2 - 0.043 13.3 0.1 0.94 8.9 0.0 3.3 4 0 0 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2110) TPR_12 PF13424.4 001309513.1_21029001_2 - 0.065 13.4 6.9 0.95 9.7 0.1 3.7 2 1 3 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.15 001309513.1_21029001_2 - 0.092 12.8 6.6 2.9 8.1 0.1 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TilS_C PF11734.6 001309513.1_21029001_2 - 0.22 10.8 1.1 6.5 6.1 0.1 3.5 3 0 0 3 3 3 0 TilS substrate C-terminal domain AAA_23 PF13476.4 001309513.1_21029001_2 - 1.8 8.9 16.6 0.55 10.6 9.6 2.6 2 0 0 2 2 2 0 AAA domain Amino_oxidase PF01593.22 001081833.1_21025001_1 - 1.2e-74 252.1 0.0 1.6e-74 251.7 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 001081833.1_21025001_1 - 2.2e-14 53.3 0.2 5.4e-14 52.1 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001081833.1_21025001_1 - 2.1e-06 27.5 0.6 4.9e-06 26.3 0.6 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.5 001081833.1_21025001_1 - 2.8e-06 26.8 0.6 4.2e-06 26.3 0.6 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 001081833.1_21025001_1 - 2.9e-06 26.5 1.4 4.3e-06 25.9 1.4 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.12 001081833.1_21025001_1 - 2e-05 23.8 0.4 0.00012 21.3 0.2 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.17 001081833.1_21025001_1 - 3e-05 23.3 0.5 4.7e-05 22.7 0.5 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.15 001081833.1_21025001_1 - 5.5e-05 22.4 0.3 9.3e-05 21.6 0.3 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.25 001081833.1_21025001_1 - 0.0001 22.6 0.4 0.00024 21.5 0.4 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001081833.1_21025001_1 - 0.00018 20.7 0.4 0.23 10.5 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.12 001081833.1_21025001_1 - 0.00054 18.6 1.0 0.00083 18.0 0.4 1.6 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.19 001081833.1_21025001_1 - 0.00099 18.3 0.2 0.0017 17.5 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.10 001081833.1_21025001_1 - 0.016 14.7 0.1 0.03 13.8 0.1 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Lycopene_cycl PF05834.10 001081833.1_21025001_1 - 0.029 13.3 0.1 0.044 12.7 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein GIDA PF01134.20 001081833.1_21025001_1 - 0.031 13.2 0.3 0.031 13.2 0.3 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A MCRA PF06100.9 001081833.1_21025001_1 - 0.057 12.1 0.0 0.089 11.4 0.0 1.3 1 0 0 1 1 1 0 MCRA family Trp_halogenase PF04820.12 001081833.1_21025001_1 - 0.29 9.8 0.6 0.43 9.2 0.6 1.2 1 0 0 1 1 1 0 Tryptophan halogenase C1-set PF07654.13 001082502.3_21022001_1 - 5.1e-22 78.0 0.0 8.7e-22 77.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001082502.3_21022001_1 - 0.0092 16.4 0.0 0.014 15.9 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001082502.3_21022001_1 - 0.016 15.1 0.0 0.027 14.4 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ion_trans PF00520.29 001163895.1_21029001_2 - 8.3e-254 837.2 98.5 2e-82 276.0 10.5 4.1 4 0 0 4 4 4 4 Ion transport protein Na_trans_assoc PF06512.11 001163895.1_21029001_2 - 3.5e-55 187.1 3.2 3.5e-55 187.1 3.2 2.1 2 0 0 2 2 2 1 Sodium ion transport-associated Na_trans_cytopl PF11933.6 001163895.1_21029001_2 - 7.8e-52 176.1 1.3 7.8e-52 176.1 1.3 2.2 2 0 0 2 2 2 1 Cytoplasmic domain of voltage-gated Na+ ion channel PKD_channel PF08016.10 001163895.1_21029001_2 - 3.1e-10 39.2 87.0 2.4e-05 23.1 2.7 10.1 6 4 3 10 10 10 7 Polycystin cation channel GPHH PF16905.3 001163895.1_21029001_2 - 2.9e-06 26.9 0.0 7.4e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated IQ PF00612.25 001163895.1_21029001_2 - 0.0093 15.5 0.4 0.033 13.8 0.4 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif UPF0239 PF06783.9 001163895.1_21029001_2 - 7.3 6.7 8.5 1.8 8.7 0.1 3.4 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0239) LEDGF PF11467.6 001082513.1_21024001_2 - 1.3e-29 102.2 4.3 1.3e-29 102.2 4.3 2.3 2 0 0 2 2 2 1 Lens epithelium-derived growth factor (LEDGF) PWWP PF00855.15 001082513.1_21024001_2 - 5.9e-14 52.2 0.1 5.9e-14 52.2 0.1 4.1 3 2 0 3 3 3 1 PWWP domain PKD PF00801.18 001163889.1_21024001_3 - 7e-11 41.7 0.3 3.6e-10 39.4 0.1 2.4 2 0 0 2 2 2 1 PKD domain Xlink PF00193.15 001085435.2_21023001_2 - 2.5e-19 69.3 1.3 5.6e-19 68.2 0.0 2.2 3 0 0 3 3 3 1 Extracellular link domain DUF1180 PF06679.10 001085435.2_21023001_2 - 0.026 14.8 0.1 0.026 14.8 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Cyclin_N PF00134.21 001081846.1_21025001_1 - 3.8e-22 78.3 0.7 4.9e-19 68.3 0.1 2.7 2 0 0 2 2 2 2 Cyclin, N-terminal domain HSP70 PF00012.18 001163884.1_21025001_2 - 5.6e-270 896.6 10.7 6.5e-270 896.3 10.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 001163884.1_21025001_2 - 4.3e-14 51.9 5.9 3.6e-13 48.9 0.4 2.7 3 1 0 3 3 3 2 MreB/Mbl protein FGGY_C PF02782.14 001163884.1_21025001_2 - 2.8e-06 27.1 0.1 7.6e-06 25.7 0.1 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.4 001163884.1_21025001_2 - 0.0026 18.0 4.3 1 9.7 0.1 3.8 3 1 0 3 3 3 2 Cell division protein FtsA Gp_dh_C PF02800.18 001163856.1_21023001_1 - 5.8e-70 233.8 0.0 8.3e-70 233.3 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.22 001163856.1_21023001_1 - 6.3e-39 132.3 0.2 1.3e-38 131.3 0.2 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.18 001163856.1_21023001_1 - 0.072 13.1 0.1 0.22 11.5 0.1 1.8 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus IL12p40_C PF10420.7 001082516.1_21023001_1 - 2.1e-23 82.5 2.1 5.9e-23 81.0 0.4 2.3 2 0 0 2 2 2 1 Cytokine interleukin-12p40 C-terminus fn3 PF00041.19 001082516.1_21023001_1 - 1.1e-05 25.6 0.5 0.00023 21.3 0.5 2.8 2 0 0 2 2 2 1 Fibronectin type III domain Ig_5 PF16681.3 001082516.1_21023001_1 - 1.4e-05 25.3 3.0 4.5e-05 23.7 0.1 2.7 2 1 1 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_3 PF13927.4 001082516.1_21023001_1 - 0.00011 22.6 6.8 0.001 19.5 0.1 3.0 3 1 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.3 001082516.1_21023001_1 - 0.00014 22.0 2.9 0.00064 19.9 0.0 3.0 2 1 2 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Ig_2 PF13895.4 001082516.1_21023001_1 - 0.0012 19.0 0.6 0.021 15.0 0.1 2.8 1 1 1 2 2 2 1 Immunoglobulin domain I-set PF07679.14 001082516.1_21023001_1 - 2.2 8.3 4.5 4.2 7.4 0.0 3.6 4 3 0 4 4 4 0 Immunoglobulin I-set domain p450 PF00067.20 001082521.1_21024001_1 - 2.3e-119 399.1 0.7 2.6e-119 398.9 0.7 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF761 PF05553.9 001082521.1_21024001_1 - 0.1 12.0 0.1 0.48 9.9 0.1 2.1 1 0 0 1 1 1 0 Cotton fibre expressed protein UPAR_LY6 PF00021.19 001163881.1_21023001_2 - 2.5e-25 88.8 45.3 7.1e-15 55.3 6.9 3.6 4 0 0 4 4 4 3 u-PAR/Ly-6 domain Toxin_1 PF00087.19 001163881.1_21023001_2 - 0.019 15.1 5.1 0.019 15.1 5.1 3.9 4 0 0 4 4 4 0 Snake toxin DUF397 PF04149.10 001163881.1_21023001_2 - 0.064 13.2 0.3 0.15 12.0 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF397) p450 PF00067.20 001082523.1_21024001_2 - 4.8e-134 447.4 0.0 6e-134 447.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TSP_C PF05735.10 001081856.1_21025001_2 - 5.3e-98 326.6 0.8 7.1e-98 326.2 0.8 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.16 001081856.1_21025001_2 - 8.9e-64 210.7 131.3 8.4e-13 47.6 12.9 9.3 7 2 1 8 8 8 7 Thrombospondin type 3 repeat COMP PF11598.6 001081856.1_21025001_2 - 2.4e-18 66.2 2.4 5.3e-18 65.1 2.4 1.6 1 0 0 1 1 1 1 Cartilage oligomeric matrix protein EGF_CA PF07645.13 001081856.1_21025001_2 - 6.2e-17 61.4 44.9 2.7e-11 43.3 8.3 5.2 4 0 0 4 4 4 3 Calcium-binding EGF domain EGF_3 PF12947.5 001081856.1_21025001_2 - 1.8e-07 31.1 46.7 0.00036 20.5 5.1 5.4 5 0 0 5 5 5 3 EGF domain cEGF PF12662.5 001081856.1_21025001_2 - 2.3e-07 30.5 20.3 1.6e-05 24.6 0.1 5.1 4 0 0 4 4 4 2 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.5 001081856.1_21025001_2 - 0.0016 18.3 1.9 0.0016 18.3 1.9 4.4 4 0 0 4 4 4 1 MSP1 EGF domain 1 EGF PF00008.25 001081856.1_21025001_2 - 0.011 15.9 8.3 0.011 15.9 8.3 5.5 5 0 0 5 5 5 0 EGF-like domain IL1 PF00340.17 001082525.2_21024001_3 - 8.2e-35 119.0 0.0 1.2e-34 118.5 0.0 1.2 1 0 0 1 1 1 1 Interleukin-1 / 18 adh_short PF00106.23 001081901.1_21026001_2 - 4.9e-38 130.4 0.4 9.8e-38 129.4 0.4 1.5 1 0 0 1 1 1 1 short chain dehydrogenase MaoC_dehydratas PF01575.17 001081901.1_21026001_2 - 5e-38 129.3 0.0 1.1e-37 128.2 0.0 1.6 1 0 0 1 1 1 1 MaoC like domain adh_short_C2 PF13561.4 001081901.1_21026001_2 - 1.5e-31 109.6 0.1 2.6e-31 108.9 0.1 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SCP2 PF02036.15 001081901.1_21026001_2 - 7.4e-25 87.2 0.1 1.6e-24 86.2 0.1 1.6 1 0 0 1 1 1 1 SCP-2 sterol transfer family KR PF08659.8 001081901.1_21026001_2 - 1.1e-14 54.6 0.4 1.8e-14 53.9 0.4 1.3 1 0 0 1 1 1 1 KR domain Alkyl_sulf_C PF14864.4 001081901.1_21026001_2 - 9e-07 29.1 0.0 1.7e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal MaoC_dehydrat_N PF13452.4 001081901.1_21026001_2 - 1.6e-05 24.9 0.0 0.00013 22.0 0.0 2.3 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase AbrB-like PF14250.4 001081901.1_21026001_2 - 0.08 12.9 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 AbrB-like transcriptional regulator DUF853 PF05872.10 001081901.1_21026001_2 - 0.12 10.8 0.5 0.19 10.2 0.5 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) IL1 PF00340.17 001082526.1_21023001_2 - 1.9e-43 146.8 0.1 3.4e-43 146.0 0.1 1.4 1 0 0 1 1 1 1 Interleukin-1 / 18 IL1_propep PF02394.14 001082526.1_21023001_2 - 4.7e-40 136.7 0.7 7.5e-40 136.1 0.1 1.6 2 0 0 2 2 2 1 Interleukin-1 propeptide MITF_TFEB_C_3_N PF15951.3 001163874.1_21029001_3 - 8.2e-49 166.0 21.3 8.2e-49 166.0 21.3 2.1 2 1 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus DUF3371 PF11851.6 001163874.1_21029001_3 - 2.1e-36 125.6 1.3 2.1e-36 125.6 1.3 3.1 2 1 0 2 2 2 1 Domain of unknown function (DUF3371) HLH PF00010.24 001163874.1_21029001_3 - 2.2e-16 59.4 0.5 5.1e-16 58.2 0.5 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Ribophorin_I PF04597.12 001163874.1_21029001_3 - 0.58 9.1 3.6 0.92 8.5 3.6 1.2 1 0 0 1 1 1 0 Ribophorin I TFIIA PF03153.11 001163874.1_21029001_3 - 7.2 6.3 16.8 11 5.7 16.6 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit zf-LITAF-like PF10601.7 001081861.2_21024001_3 - 2.7e-25 88.3 13.2 6.3e-25 87.1 13.2 1.7 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain ADH_zinc_N PF00107.24 001082528.1_21024001_1 - 6.9e-25 87.3 0.1 1.2e-24 86.5 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001082528.1_21024001_1 - 6.3e-24 83.8 0.9 1.3e-23 82.9 0.9 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.3 001082528.1_21024001_1 - 9.9e-05 21.8 0.0 0.00015 21.2 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.4 001082528.1_21024001_1 - 0.00019 22.3 0.0 0.00036 21.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.12 001082528.1_21024001_1 - 0.0025 17.3 0.2 0.0044 16.5 0.2 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.17 001082528.1_21024001_1 - 0.019 14.2 0.3 0.031 13.5 0.3 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 7tm_1 PF00001.19 001163982.1_21023001_3 - 1.6e-66 224.2 13.3 2e-66 223.9 13.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ank_2 PF12796.5 001317262.1_21025001_1 - 4.4e-26 91.2 7.7 1.7e-12 47.6 0.3 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001317262.1_21025001_1 - 9.6e-21 73.7 3.1 4.6e-05 23.7 0.0 5.8 4 1 2 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.28 001317262.1_21025001_1 - 4.2e-19 67.9 9.9 0.0045 17.3 0.0 7.0 6 2 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.4 001317262.1_21025001_1 - 1.6e-18 64.7 4.4 0.046 14.2 0.1 7.3 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.4 001317262.1_21025001_1 - 3.6e-12 46.2 7.7 0.0012 19.0 0.1 6.3 6 2 2 8 8 8 4 Ankyrin repeats (many copies) Thymosin PF01290.18 001081865.1_21021001_3 - 1.1e-22 79.3 6.4 2.2e-22 78.3 6.4 1.5 1 0 0 1 1 1 1 Thymosin beta-4 family Pkinase PF00069.23 001163985.1_21029001_2 - 4.1e-63 213.1 0.0 4.1e-63 213.1 0.0 2.6 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.15 001163985.1_21029001_2 - 3.2e-30 105.1 0.0 8.5e-30 103.8 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase Rho_Binding PF08912.9 001163985.1_21029001_2 - 1.1e-22 80.5 15.9 1.1e-22 80.5 15.9 12.7 4 3 8 14 14 14 1 Rho Binding PH PF00169.27 001163985.1_21029001_2 - 1.6e-06 28.5 0.3 4.7e-05 23.7 0.3 2.9 1 1 0 1 1 1 1 PH domain C1_1 PF00130.20 001163985.1_21029001_2 - 0.00068 19.3 5.3 0.00068 19.3 5.3 2.3 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.22 001163985.1_21029001_2 - 0.0096 16.5 1.6 0.031 14.8 1.6 2.0 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.21 001163985.1_21029001_2 - 0.038 13.8 0.1 0.038 13.8 0.1 3.4 3 1 1 4 4 4 0 Phosphotransferase enzyme family DUF1192 PF06698.9 001163985.1_21029001_2 - 0.26 11.2 5.7 0.066 13.1 0.3 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) zf-C2H2 PF00096.24 001163860.1_21028001_1 - 4.3e-19 67.7 31.2 0.00026 21.1 0.6 6.0 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001163860.1_21028001_1 - 1.1e-11 44.5 34.5 3.4e-06 27.1 1.5 5.7 5 0 0 5 5 5 3 Zinc-finger double domain FOXP-CC PF16159.3 001163860.1_21028001_1 - 5.3e-09 36.4 19.0 0.00038 20.9 2.9 4.6 1 1 3 4 4 4 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.4 001163860.1_21028001_1 - 1.6e-06 28.3 30.5 0.006 17.2 0.5 5.8 5 0 0 5 5 5 3 C2H2-type zinc finger zf-met PF12874.5 001163860.1_21028001_1 - 0.02 15.2 1.5 0.36 11.1 0.5 3.0 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.3 001163860.1_21028001_1 - 0.5 10.6 8.7 3.8 7.8 4.8 3.0 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.3 001163860.1_21028001_1 - 0.52 10.3 12.1 6.2 6.8 0.6 3.2 2 1 1 3 3 3 0 Aberrant zinc-finger CHORD PF04968.10 001163860.1_21028001_1 - 0.69 10.5 20.8 2.8 8.6 2.5 4.3 2 1 2 4 4 4 0 CHORD PcF PF09461.8 001163860.1_21028001_1 - 1.5 9.1 5.0 23 5.3 0.3 3.7 2 1 1 3 3 3 0 Phytotoxin PcF protein zf-H2C2_5 PF13909.4 001163860.1_21028001_1 - 4.1 7.1 8.9 1.6 8.4 0.0 3.4 3 0 0 3 3 3 0 C2H2-type zinc-finger domain IL17 PF06083.9 001163860.1_21028001_1 - 5.8 7.3 7.2 0.3 11.5 0.1 2.5 3 0 0 3 3 2 0 Interleukin-17 zf-FPG_IleRS PF06827.12 001163860.1_21028001_2 - 0.0099 15.6 0.5 0.026 14.2 0.5 1.7 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS Cathelicidins PF00666.15 001081869.1_21022001_1 - 5.1e-50 167.9 0.2 6.4e-50 167.5 0.2 1.1 1 0 0 1 1 1 1 Cathelicidin Spp-24 PF07448.9 001081869.1_21022001_1 - 0.0077 16.3 0.1 0.013 15.5 0.1 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain IL8 PF00048.18 001083951.2_21024001_3 - 9.7e-15 54.3 1.0 1.6e-14 53.6 1.0 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like TPMT PF05724.9 001081905.1_21022001_1 - 4.2e-77 258.6 0.0 4.7e-77 258.4 0.0 1.0 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_25 PF13649.4 001081905.1_21022001_1 - 0.0012 19.4 0.0 0.015 15.8 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001081905.1_21022001_1 - 0.013 16.0 0.0 0.046 14.2 0.0 1.9 2 1 0 2 2 2 0 Methyltransferase domain SSF PF00474.15 001081872.1_21025001_2 - 7.8e-170 565.0 24.6 7.8e-170 565.0 24.6 1.6 2 0 0 2 2 2 1 Sodium:solute symporter family TadF PF16964.3 001081872.1_21025001_2 - 0.048 13.3 0.0 0.099 12.3 0.0 1.5 1 0 0 1 1 1 0 Putative tight adherence pilin protein F Ank_2 PF12796.5 001163956.1_21025001_1 - 2.2e-31 108.2 8.4 1.1e-11 45.0 1.1 3.6 1 1 4 5 5 5 4 Ankyrin repeats (3 copies) Ion_trans PF00520.29 001163956.1_21025001_1 - 4.9e-18 65.1 21.8 7.8e-18 64.5 21.8 1.3 1 0 0 1 1 1 1 Ion transport protein Ank_3 PF13606.4 001163956.1_21025001_1 - 3.4e-17 60.6 4.7 6.2e-05 23.0 0.1 6.1 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.28 001163956.1_21025001_1 - 1.5e-16 59.9 5.4 2.2e-05 24.6 0.3 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.4 001163956.1_21025001_1 - 2.5e-15 56.5 7.3 7.4e-05 23.1 0.0 5.0 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 001163956.1_21025001_1 - 4.4e-12 45.9 6.7 0.00021 21.4 0.0 4.5 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.15 001163863.1_21029001_3 - 3.7e-104 347.5 0.0 5.1e-104 347.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001163863.1_21029001_3 - 6.4e-45 153.4 0.0 1.1e-44 152.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 001163863.1_21029001_3 - 1.3e-35 121.2 0.0 1.4e-14 53.8 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 001163863.1_21029001_3 - 4.3e-34 116.8 0.0 1.7e-12 47.6 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001163863.1_21029001_3 - 7.1e-25 87.0 0.6 9.7e-11 41.7 0.1 4.1 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.23 001163863.1_21029001_3 - 1.3e-22 79.6 0.0 1.8e-08 34.3 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001163863.1_21029001_3 - 5.4e-15 55.4 0.7 0.00039 20.4 0.0 5.2 4 1 0 4 4 4 3 Immunoglobulin V-set domain Ig_5 PF16681.3 001163863.1_21029001_3 - 1.3e-06 28.6 0.0 0.12 12.7 0.0 3.8 3 0 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 001163863.1_21029001_3 - 0.0019 18.1 0.1 0.19 11.7 0.0 3.5 3 1 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Herpes_gE PF02480.14 001163863.1_21029001_3 - 0.022 13.4 0.1 0.53 8.8 0.0 2.6 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E Kinase-like PF14531.4 001163863.1_21029001_3 - 0.14 11.3 0.0 0.46 9.6 0.0 1.7 2 0 0 2 2 2 0 Kinase-like zf-C4 PF00105.16 001163959.1_21023001_1 - 1e-28 99.4 15.0 1.9e-28 98.6 15.0 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001163959.1_21023001_1 - 3.6e-24 85.4 0.4 7.5e-24 84.3 0.1 1.6 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-RRPl_C4 PF17026.3 001163959.1_21023001_1 - 0.1 12.5 3.0 0.19 11.7 3.0 1.4 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type TGF_beta PF00019.18 001081909.1_21023001_3 - 7.2e-31 107.1 1.1 1.5e-30 106.0 1.1 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 001081909.1_21023001_3 - 1.2e-09 38.2 0.7 9.8e-09 35.2 0.7 2.3 1 1 0 1 1 1 1 TGF-beta propeptide FGF PF00167.16 001163883.1_21024001_2 - 1e-47 161.2 1.9 1.6e-47 160.6 1.9 1.3 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 001163883.1_21024001_2 - 0.041 14.0 0.0 0.074 13.1 0.0 1.5 1 0 0 1 1 1 0 Fascin domain 7tm_1 PF00001.19 001093769.1_21025001_1 - 6.2e-08 32.1 12.0 1.4e-07 30.9 12.0 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001093769.1_21025001_1 - 0.007 15.6 5.2 0.012 14.8 5.2 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx CAP PF00188.24 001081874.1_21023001_2 - 3.3e-20 73.0 4.3 5.2e-20 72.4 4.3 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Crisp PF08562.8 001081874.1_21023001_2 - 4.9e-20 71.7 20.7 1.6e-19 70.1 20.7 1.9 1 0 0 1 1 1 1 Crisp Lipocalin PF00061.21 001081951.1_21023001_3 - 8.3e-21 74.6 0.0 1.1e-20 74.1 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.10 001081951.1_21023001_3 - 3.2e-05 23.8 0.0 5e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Lipocalin-like domain Triabin PF03973.11 001081951.1_21023001_3 - 0.21 11.3 0.8 1.4 8.7 0.8 2.1 1 1 0 1 1 1 0 Triabin fn2 PF00040.17 001081878.1_21022001_1 - 3.9e-31 106.9 26.5 9.8e-17 60.8 8.2 2.5 3 0 0 3 3 3 2 Fibronectin type II domain Augurin PF15187.4 001242543.1_21022001_3 - 3.1e-55 185.1 4.5 4e-55 184.7 4.5 1.1 1 0 0 1 1 1 1 Oesophageal cancer-related gene 4 DUF1700 PF08006.9 001242543.1_21022001_3 - 0.036 13.5 0.0 0.067 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) MIF4G PF02854.17 001163871.1_21029001_1 - 4.3e-69 232.3 10.8 7.3e-69 231.5 10.8 1.4 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.15 001163871.1_21029001_1 - 9e-30 102.8 0.3 7e-29 100.0 0.1 2.5 2 1 0 2 2 2 1 MA3 domain W2 PF02020.16 001163871.1_21029001_1 - 3.8e-19 68.5 2.3 1.6e-18 66.5 2.3 2.2 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Cep57_MT_bd PF06657.11 001163871.1_21029001_1 - 1.2 9.5 6.5 0.84 10.0 3.0 2.6 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Trypsin PF00089.24 001081881.1_21022001_1 - 1.6e-67 227.4 0.0 1.8e-67 227.2 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001081881.1_21022001_1 - 2.7e-06 28.2 0.0 5.4e-06 27.2 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001081881.1_21022001_1 - 0.028 14.7 0.0 0.054 13.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Pico_P2A PF00947.17 001081881.1_21022001_1 - 0.056 13.3 0.1 0.16 11.9 0.0 1.8 2 0 0 2 2 2 0 Picornavirus core protein 2A 7tm_1 PF00001.19 001163824.1_21023001_2 - 2.1e-40 138.6 19.6 3e-40 138.0 19.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001163824.1_21023001_2 - 2.1e-06 27.2 22.3 2.8e-06 26.8 22.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001163824.1_21023001_2 - 0.00091 18.9 19.9 0.0028 17.3 19.9 1.8 1 1 0 1 1 1 1 Olfactory receptor JTB PF05439.10 001163824.1_21023001_2 - 0.029 14.3 1.1 0.082 12.8 1.1 1.7 1 0 0 1 1 1 0 Jumping translocation breakpoint protein (JTB) Ninjurin PF04923.10 001163824.1_21023001_2 - 7.6 6.4 11.2 2.6 7.9 3.0 2.8 2 1 1 3 3 3 0 Ninjurin AMPK1_CBM PF16561.3 001163958.1_21023001_2 - 3.5e-34 116.8 0.1 5.6e-34 116.1 0.1 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.13 001163958.1_21023001_2 - 1.9e-27 95.2 1.7 3.7e-27 94.3 1.7 1.5 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM_48 PF02922.16 001163958.1_21023001_2 - 0.04 14.1 0.0 0.078 13.2 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) HlyIII PF03006.18 001163830.1_21023001_2 - 1.6e-71 240.4 21.9 2e-71 240.1 21.9 1.1 1 0 0 1 1 1 1 Haemolysin-III related Androgen_recep PF02166.14 001163891.1_21026001_1 - 3.3e-223 741.7 38.9 4.6e-223 741.3 38.9 1.2 1 0 0 1 1 1 1 Androgen receptor Hormone_recep PF00104.28 001163891.1_21026001_1 - 3.1e-31 108.5 2.9 5.1e-31 107.8 2.9 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001163891.1_21026001_1 - 4.3e-27 94.2 14.4 8.7e-27 93.3 14.4 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) CBS PF00571.26 001163983.1_21024001_2 - 7e-35 119.1 2.3 2.4e-10 40.6 0.4 4.2 4 0 0 4 4 4 4 CBS domain Striatin PF08232.10 001163829.1_21028001_1 - 3e-49 167.4 4.7 7.2e-49 166.2 4.7 1.7 1 0 0 1 1 1 1 Striatin family WD40 PF00400.30 001163829.1_21028001_1 - 5.4e-34 115.5 10.4 5.7e-08 33.2 0.1 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001163829.1_21028001_1 - 1.7e-06 28.1 0.1 0.2 11.8 0.0 4.3 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 001163829.1_21028001_1 - 0.00067 18.3 0.3 1 7.8 0.0 3.0 4 0 0 4 4 4 2 Nucleoporin Nup120/160 DUF4482 PF14818.4 001163829.1_21028001_1 - 0.058 14.1 2.9 0.15 12.8 2.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) Carb_anhydrase PF00194.19 001163954.1_21022001_1 - 3.9e-89 298.4 0.0 4.4e-89 298.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Bax1-I PF01027.18 001309346.1_21025001_2 - 3.8e-40 137.8 13.0 5.8e-40 137.2 13.0 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF4680 PF15730.3 001195221.1_21022001_1 - 0.18 11.9 6.3 0.24 11.6 6.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4680) FGF PF00167.16 001195221.1_21022001_3 - 8.8e-43 145.3 0.0 1e-42 145.0 0.0 1.0 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 001195221.1_21022001_3 - 7.6e-06 26.0 0.1 0.014 15.5 0.0 1.6 1 1 1 2 2 2 2 Fascin domain IL1 PF00340.17 001195221.1_21022001_3 - 0.0013 18.3 0.0 0.0019 17.8 0.0 1.3 1 0 0 1 1 1 1 Interleukin-1 / 18 SH3BGR PF04908.13 001242455.1_21022001_1 - 1.9e-36 124.0 0.0 3.1e-36 123.4 0.0 1.3 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.22 001242455.1_21022001_1 - 8.2e-07 29.0 0.0 1.3e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin 7tm_1 PF00001.19 001159691.1_21024001_3 - 3e-35 121.6 9.9 5.6e-35 120.7 9.9 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001159691.1_21024001_3 - 0.0058 15.9 0.2 0.0058 15.9 0.2 3.2 3 1 0 3 3 3 2 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4149 PF13664.4 001159691.1_21024001_3 - 9.7 6.5 6.7 3.2 8.0 0.6 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4149) MHC_I PF00129.16 001082506.1_21023001_1 - 6.3e-96 318.9 0.8 1.1e-95 318.2 0.8 1.4 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001082506.1_21023001_1 - 2.5e-17 63.0 0.0 5.1e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001082506.1_21023001_1 - 1.1e-11 44.3 1.8 2.2e-11 43.3 1.8 1.5 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001082506.1_21023001_1 - 2.3e-05 24.8 0.4 0.0029 18.0 0.1 2.6 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001082506.1_21023001_1 - 8e-05 22.5 1.2 0.00011 22.1 0.1 1.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 001082506.1_21023001_1 - 0.0027 17.9 0.0 0.0064 16.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001082506.1_21023001_1 - 0.0054 16.8 0.2 0.017 15.1 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 001082506.1_21023001_1 - 0.074 13.0 0.0 0.39 10.7 0.0 2.0 1 1 1 2 2 2 0 Immunoglobulin I-set domain PepSY_TM PF03929.14 001082506.1_21023001_1 - 0.11 11.7 3.5 1.9 7.7 3.5 2.1 1 1 0 1 1 1 0 PepSY-associated TM region SCAN PF02023.15 001309282.1_21029001_2 - 3.3e-42 142.1 1.4 6e-42 141.3 1.4 1.4 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 001309282.1_21029001_2 - 1.3e-22 79.0 15.5 7.9e-08 32.3 0.3 6.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 001309282.1_21029001_2 - 4e-21 74.1 18.3 8.2e-06 25.9 1.9 5.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001309282.1_21029001_2 - 6e-07 29.6 29.9 0.012 16.2 1.4 6.2 5 0 0 5 5 5 4 C2H2-type zinc finger zf-LYAR PF08790.9 001309282.1_21029001_2 - 0.015 15.1 6.4 17 5.3 0.0 4.4 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger zf-C2H2_jaz PF12171.6 001309282.1_21029001_2 - 0.14 12.3 13.0 6.4 7.1 0.0 5.2 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 001309282.1_21029001_2 - 2.8 8.0 21.1 0.13 12.3 1.4 3.1 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2H2_6 PF13912.4 001309282.1_21029001_2 - 3.6 7.5 28.3 0.06 13.2 1.0 5.2 5 0 0 5 5 5 0 C2H2-type zinc finger XPA_N PF01286.16 001309282.1_21029001_2 - 4.4 7.3 17.1 12 5.9 0.1 5.2 5 0 0 5 5 5 0 XPA protein N-terminal hDGE_amylase PF14701.4 001110308.1_21029001_3 - 6.6e-163 542.7 0.1 9.1e-163 542.3 0.1 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.12 001110308.1_21029001_3 - 1.3e-141 471.8 0.0 1.9e-141 471.3 0.0 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.4 001110308.1_21029001_3 - 2.3e-86 289.6 0.0 3.3e-86 289.1 0.0 1.3 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.4 001110308.1_21029001_3 - 1.7e-19 69.6 0.0 3.1e-19 68.8 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.22 001110308.1_21029001_3 - 0.0026 17.3 0.0 0.0044 16.5 0.0 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF4038 PF13204.4 001110308.1_21029001_3 - 0.056 12.9 0.0 0.097 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4038) PglZ PF08665.10 001110308.1_21029001_3 - 0.11 12.5 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 PglZ domain Ephrin PF00812.15 001114943.1_21023001_1 - 2.4e-51 173.3 0.3 2e-50 170.3 0.1 2.0 2 0 0 2 2 2 1 Ephrin TMEM132D_C PF15706.3 001114943.1_21023001_1 - 0.0025 17.4 0.0 0.0045 16.6 0.0 1.4 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF4381 PF14316.4 001114943.1_21023001_1 - 0.043 13.9 0.0 0.073 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) EphA2_TM PF14575.4 001114943.1_21023001_1 - 0.086 13.5 0.0 0.18 12.5 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.4 001114943.1_21023001_1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family ECSCR PF15820.3 001114943.1_21023001_1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Tmemb_9 PF05434.9 001114943.1_21023001_3 - 0.058 13.1 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 TMEM9 Ald_Xan_dh_C2 PF02738.16 001283088.1_21029001_1 - 1.7e-184 614.2 0.0 2.2e-184 613.8 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001283088.1_21029001_1 - 1.2e-43 148.7 0.0 3.4e-43 147.2 0.0 1.8 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 001283088.1_21029001_1 - 5.7e-32 110.2 0.7 1.3e-31 109.1 0.7 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 001283088.1_21029001_1 - 8.8e-31 105.6 0.2 2.1e-30 104.4 0.2 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 001283088.1_21029001_1 - 8.9e-30 102.8 0.1 8.2e-28 96.5 0.0 3.0 3 0 0 3 3 3 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001283088.1_21029001_1 - 1.7e-07 30.9 0.1 1.7e-07 30.9 0.1 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DHODB_Fe-S_bind PF10418.7 001283088.1_21029001_1 - 0.02 14.6 1.3 0.061 13.0 1.3 1.8 1 0 0 1 1 1 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B DUF1930 PF09122.8 001283088.1_21029001_1 - 0.061 13.2 0.6 2.8 7.9 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1930) Sugar_tr PF00083.22 001081877.1_21025001_2 - 8e-136 453.3 21.7 9.5e-136 453.1 21.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001081877.1_21025001_2 - 1.5e-18 66.7 28.7 3.6e-18 65.5 22.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily GM_CSF PF01109.15 001081882.1_21022001_1 - 9.5e-69 229.1 0.2 1.2e-68 228.8 0.2 1.1 1 0 0 1 1 1 1 Granulocyte-macrophage colony-stimulating factor MHC_I PF00129.16 001082507.1_21023001_1 - 1.4e-85 285.2 1.2 1.8e-85 284.9 1.2 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001082507.1_21023001_1 - 3.2e-15 56.2 0.0 6.2e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 001082507.1_21023001_1 - 0.00017 21.0 0.0 0.00023 20.6 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain Ig_3 PF13927.4 001082507.1_21023001_1 - 0.00055 20.4 0.1 0.027 15.0 0.1 2.4 1 1 1 2 2 2 2 Immunoglobulin domain MHC_I_C PF06623.9 001082507.1_21023001_1 - 0.0066 16.2 2.3 0.012 15.4 2.3 1.5 1 0 0 1 1 1 1 MHC_I C-terminus C2-set_2 PF08205.10 001082507.1_21023001_1 - 0.0077 16.2 0.1 0.017 15.1 0.1 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001082507.1_21023001_1 - 0.052 13.6 0.1 0.12 12.5 0.1 1.6 1 0 0 1 1 1 0 Immunoglobulin domain MHC_I PF00129.16 001082508.1_21023001_1 - 2.6e-87 290.9 0.2 3.5e-87 290.4 0.2 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001082508.1_21023001_1 - 2e-17 63.3 0.1 5e-17 62.0 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001082508.1_21023001_1 - 1.1e-12 47.4 12.9 9e-12 44.6 9.6 2.4 2 0 0 2 2 2 1 MHC_I C-terminus Ig_3 PF13927.4 001082508.1_21023001_1 - 4.7e-05 23.8 0.9 0.0042 17.5 0.1 2.8 2 1 1 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.10 001082508.1_21023001_1 - 0.00023 21.0 0.1 0.00052 19.9 0.1 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain MHC_I_3 PF16497.3 001082508.1_21023001_1 - 0.00038 19.9 0.0 0.00046 19.6 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain ig PF00047.23 001082508.1_21023001_1 - 0.018 15.1 0.0 0.046 13.8 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.4 001082508.1_21023001_1 - 0.019 15.1 0.0 0.057 13.6 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain PepSY_TM PF03929.14 001082508.1_21023001_1 - 1.6 7.9 3.7 12 5.0 3.9 1.9 1 1 0 1 1 1 0 PepSY-associated TM region Forkhead PF00250.16 001163272.1_21025001_1 - 2.4e-26 91.8 0.2 4.2e-26 91.0 0.2 1.4 1 0 0 1 1 1 1 Forkhead domain FOXP-CC PF16159.3 001163272.1_21025001_1 - 2.8e-26 91.8 2.3 2.8e-26 91.8 2.3 2.3 3 0 0 3 3 3 1 FOXP coiled-coil domain GSHPx PF00255.17 001166479.1_21022001_1 - 4.4e-37 125.8 0.0 5.6e-37 125.5 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase Fer2_3 PF13085.4 001163823.1_21022001_2 - 1.2e-33 115.2 0.0 2.2e-33 114.4 0.0 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.4 001163823.1_21022001_2 - 2.4e-09 37.4 4.9 2.4e-09 37.4 4.9 2.6 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer4_8 PF13183.4 001163823.1_21022001_2 - 2.9e-08 33.9 21.0 4.4e-07 30.1 7.6 3.1 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_10 PF13237.4 001163823.1_21022001_2 - 8.5e-07 28.9 2.6 8.5e-07 28.9 2.6 2.9 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.5 001163823.1_21022001_2 - 0.0019 18.6 13.5 0.014 15.8 6.2 3.0 2 2 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.4 001163823.1_21022001_2 - 0.0032 17.5 5.1 0.0032 17.5 5.1 3.0 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.25 001163823.1_21022001_2 - 0.0034 17.2 0.3 0.0034 17.2 0.3 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Furin-like_2 PF15913.3 001109680.1_21022001_1 - 2.1e-47 159.6 20.8 2.1e-47 159.6 20.8 1.8 2 0 0 2 2 2 1 Furin-like repeat, cysteine-rich TSP_1 PF00090.17 001109680.1_21022001_1 - 0.00045 20.3 5.9 0.00045 20.3 5.9 4.1 4 1 1 5 5 5 1 Thrombospondin type 1 domain Gal-bind_lectin PF00337.20 001309335.1_21025001_1 - 7.8e-78 258.4 0.1 2.4e-40 137.1 0.0 2.2 2 0 0 2 2 2 2 Galactoside-binding lectin WIF PF02019.16 001309335.1_21025001_1 - 0.00042 19.9 0.0 0.07 12.7 0.0 2.4 2 0 0 2 2 2 2 WIF domain Arm PF00514.21 001122762.1_21025001_1 - 3.6e-43 144.2 19.2 8.7e-08 31.8 0.1 12.1 13 0 0 13 13 13 7 Armadillo/beta-catenin-like repeat Cnd1 PF12717.5 001122762.1_21025001_1 - 3.5e-09 36.7 2.3 0.0033 17.3 0.3 4.5 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 001122762.1_21025001_1 - 4.6e-07 30.0 6.6 1.1 9.7 0.0 6.4 5 1 1 6 6 6 2 HEAT-like repeat HEAT PF02985.20 001122762.1_21025001_1 - 1.1e-06 28.2 1.5 16 5.9 0.0 5.9 5 0 0 5 5 5 0 HEAT repeat Adaptin_N PF01602.18 001122762.1_21025001_1 - 1.4e-06 27.1 2.1 0.00081 17.9 1.1 3.2 3 0 0 3 3 3 2 Adaptin N terminal region HEAT_2 PF13646.4 001122762.1_21025001_1 - 2.2e-06 27.8 6.9 0.029 14.6 0.3 5.1 4 1 1 5 5 5 1 HEAT repeats KAP PF05804.10 001122762.1_21025001_1 - 0.00015 20.0 1.6 0.03 12.3 0.0 3.4 1 1 1 3 3 3 1 Kinesin-associated protein (KAP) Atx10homo_assoc PF09759.7 001122762.1_21025001_1 - 0.00071 19.5 1.4 0.011 15.7 0.2 3.5 3 2 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain DUF3361 PF11841.6 001122762.1_21025001_1 - 0.00072 19.4 2.6 1.7 8.4 0.0 4.7 2 1 2 5 5 5 1 Domain of unknown function (DUF3361) Arm_2 PF04826.11 001122762.1_21025001_1 - 0.01 15.2 3.5 0.57 9.4 0.0 3.6 2 1 1 3 3 3 0 Armadillo-like Queuosine_synth PF02547.13 001122762.1_21025001_1 - 0.015 14.3 0.5 0.033 13.2 0.1 1.7 2 0 0 2 2 2 0 Queuosine biosynthesis protein RasGEF_N_2 PF14663.4 001122762.1_21025001_1 - 0.13 12.5 11.6 5.5 7.3 0.0 5.0 6 2 1 7 7 6 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Caveolin PF01146.15 001114143.1_21026001_1 - 4.3e-59 198.1 1.6 6.9e-59 197.5 1.6 1.3 1 0 0 1 1 1 1 Caveolin wnt PF00110.17 001114150.1_21025001_2 - 9.1e-122 406.2 24.6 1.1e-121 405.9 24.6 1.1 1 0 0 1 1 1 1 wnt family bZIP_2 PF07716.13 001278933.1_21023001_2 - 0.13 12.2 1.1 0.3 11.1 1.1 1.5 1 0 0 1 1 1 0 Basic region leucine zipper MHC_I PF00129.16 001278933.1_21023001_3 - 3.9e-92 306.6 0.4 5.1e-92 306.2 0.4 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001278933.1_21023001_3 - 3.1e-17 62.7 0.0 6.7e-17 61.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001278933.1_21023001_3 - 2.8e-11 43.0 5.6 5e-11 42.2 5.6 1.4 1 0 0 1 1 1 1 MHC_I C-terminus C2-set_2 PF08205.10 001278933.1_21023001_3 - 3.6e-05 23.6 0.5 8.4e-05 22.4 0.0 1.9 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 001278933.1_21023001_3 - 0.00025 21.5 1.7 0.0038 17.7 0.1 2.7 2 1 1 3 3 3 2 Immunoglobulin domain ig PF00047.23 001278933.1_21023001_3 - 0.0033 17.4 0.0 0.016 15.3 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001278933.1_21023001_3 - 0.0066 16.6 0.0 0.018 15.2 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Casein PF00363.16 001081883.1_21023001_3 - 1.1e-06 29.0 11.0 1.1e-06 29.0 11.0 2.0 1 1 1 2 2 2 1 Casein Casein_kappa PF00997.16 001081884.1_21022001_2 - 1.9e-81 271.7 18.4 2.4e-81 271.4 18.4 1.1 1 0 0 1 1 1 1 Kappa casein Lipocalin PF00061.21 001081903.2_21022001_2 - 7.6e-13 48.7 2.2 9.3e-13 48.5 2.2 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001081903.2_21022001_2 - 0.0012 18.6 2.0 0.0017 18.2 2.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_4 PF13648.4 001081903.2_21022001_2 - 0.027 15.3 0.6 0.052 14.4 0.6 1.5 1 0 0 1 1 1 0 Lipocalin-like domain Ald_Xan_dh_C2 PF02738.16 001278934.1_21029001_1 - 5.1e-183 609.3 0.0 6.8e-183 608.9 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001278934.1_21029001_1 - 8.4e-43 145.9 0.0 1.7e-42 145.0 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 001278934.1_21029001_1 - 1.5e-30 105.6 4.4 2.3e-30 105.1 3.1 2.0 2 0 0 2 2 2 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 001278934.1_21029001_1 - 1.1e-29 102.0 0.4 3.3e-29 100.5 0.4 1.9 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 001278934.1_21029001_1 - 3.6e-25 88.0 0.0 3e-24 85.0 0.0 2.5 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001278934.1_21029001_1 - 1.3e-08 34.6 0.6 1.1e-07 31.5 0.0 2.6 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain FAD_binding_4 PF01565.21 001163951.1_21024001_1 - 4.4e-15 55.5 0.1 7e-15 54.8 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Thiolase_N PF00108.21 001309272.1_21024001_1 - 2.8e-93 311.9 0.2 4e-93 311.4 0.2 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 001309272.1_21024001_1 - 1.3e-50 170.0 0.1 2.5e-50 169.1 0.1 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.24 001309272.1_21024001_1 - 0.0013 18.2 0.9 0.024 14.1 0.4 2.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain IL15 PF02372.13 001163986.1_21021001_1 - 2.9e-59 198.8 4.7 2.9e-59 198.8 4.7 1.3 2 0 0 2 2 2 1 Interleukin 15 Pkr1 PF08636.8 001163986.1_21021001_1 - 0.33 11.0 2.2 0.67 10.0 1.3 2.0 1 1 1 2 2 2 0 ER protein Pkr1 Sugar_tr PF00083.22 001163971.1_21025001_3 - 1.6e-159 531.4 21.1 2.2e-159 531.0 21.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001163971.1_21025001_3 - 3e-18 65.7 29.0 1.5e-16 60.2 24.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2127 PF09900.7 001163971.1_21025001_3 - 0.0078 16.3 1.2 0.027 14.6 1.2 1.9 1 0 0 1 1 1 1 Predicted membrane protein (DUF2127) TRI12 PF06609.11 001163971.1_21025001_3 - 0.0097 14.2 2.6 0.019 13.2 2.6 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Hanta_G1 PF01567.14 001163971.1_21025001_3 - 0.051 12.1 0.7 0.51 8.8 0.7 2.1 2 0 0 2 2 2 0 Hantavirus glycoprotein G1 DUF523 PF04463.10 001163971.1_21025001_3 - 0.087 12.7 0.1 0.14 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF523) Pox_EPC_I2-L1 PF12575.6 001163971.1_21025001_3 - 0.2 11.8 2.3 1.1 9.3 2.3 2.4 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 DUF3980 PF13140.4 001163971.1_21025001_3 - 1.9 8.9 12.4 4.4 7.7 0.5 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3980) Ald_Xan_dh_C2 PF02738.16 001287267.1_21029001_1 - 1.5e-188 627.6 0.1 2e-188 627.1 0.1 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001287267.1_21029001_1 - 2e-44 151.2 0.0 5e-44 149.9 0.0 1.7 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 001287267.1_21029001_1 - 2e-32 111.7 0.0 4.2e-32 110.6 0.0 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 001287267.1_21029001_1 - 6.7e-31 105.9 0.7 2.1e-30 104.4 0.7 1.9 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 001287267.1_21029001_1 - 5.3e-30 103.5 0.0 1.6e-29 102.0 0.0 1.9 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001287267.1_21029001_1 - 6.3e-08 32.3 0.3 6.3e-08 32.3 0.3 2.9 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain MHCassoc_trimer PF08831.8 001099770.1_21023001_1 - 5.2e-35 119.1 5.0 8.7e-35 118.4 5.0 1.4 1 0 0 1 1 1 1 Class II MHC-associated invariant chain trimerisation domain MHC2-interact PF09307.8 001099770.1_21023001_1 - 1.8e-34 117.9 0.9 1.8e-34 117.9 0.9 1.8 2 0 0 2 2 2 1 CLIP, MHC2 interacting Clusterin PF01093.15 001081944.1_21024001_3 - 5.2e-159 529.7 19.5 6e-159 529.5 19.5 1.0 1 0 0 1 1 1 1 Clusterin Sec23_trunk PF04811.13 001081944.1_21024001_3 - 9.5 5.6 8.2 4.5 6.6 1.7 2.8 2 1 1 3 3 3 0 Sec23/Sec24 trunk domain Ribosomal_L10 PF00466.18 001252576.1_21023001_2 - 3.9e-22 78.1 0.0 7.4e-22 77.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.17 001252576.1_21023001_2 - 1.5e-20 73.4 5.2 1.5e-20 73.4 5.2 1.8 2 0 0 2 2 2 1 60s Acidic ribosomal protein DEAD PF00270.27 001309276.1_21029001_3 - 3.6e-50 170.0 0.1 1.2e-49 168.3 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001309276.1_21029001_3 - 6.8e-27 93.9 0.0 1.2e-25 89.9 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CdAMP_rec PF06153.9 001309276.1_21029001_3 - 0.1 12.7 0.1 0.21 11.7 0.1 1.5 1 0 0 1 1 1 0 Cyclic-di-AMP receptor Peptidase_M1 PF01433.18 001309464.1_21027001_1 - 1.2e-132 442.7 0.1 1.6e-132 442.4 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.6 001309464.1_21027001_1 - 1.1e-72 245.1 0.2 1.6e-72 244.6 0.2 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain MSP7_C PF12948.5 001309464.1_21027001_1 - 0.037 14.5 0.4 0.084 13.4 0.4 1.5 1 0 0 1 1 1 0 MSP7-like protein C-terminal domain TSLP PF15216.4 001164063.2_21022001_2 - 6.7e-48 161.9 5.8 7.9e-48 161.7 5.8 1.0 1 0 0 1 1 1 1 Thymic stromal lymphopoietin GTP_EFTU PF00009.25 001308310.1_21029001_1 - 1.2e-35 122.7 0.0 8.2e-35 120.0 0.0 2.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.6 001308310.1_21029001_1 - 5.3e-19 68.2 0.1 5.3e-19 68.2 0.1 2.3 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.4 001308310.1_21029001_1 - 2.9e-14 52.7 0.4 6.6e-14 51.5 0.4 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.23 001308310.1_21029001_1 - 3.5e-12 46.4 8.6 1.9e-09 37.6 0.2 3.7 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 001308310.1_21029001_1 - 1.2e-06 28.4 0.3 8.4e-06 25.7 0.1 2.7 3 0 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.11 001308310.1_21029001_1 - 0.00087 19.4 0.0 0.0023 18.0 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase YtpI PF14007.4 001308310.1_21029001_2 - 0.058 13.4 0.7 0.14 12.1 0.7 1.6 1 0 0 1 1 1 0 YtpI-like protein MAPEG PF01124.16 001163965.1_21022001_2 - 3.1e-09 36.7 1.6 4.2e-09 36.3 1.6 1.2 1 0 0 1 1 1 1 MAPEG family DcuC PF03606.13 001163965.1_21022001_2 - 0.0082 14.5 0.3 0.012 14.0 0.3 1.3 1 1 0 1 1 1 1 C4-dicarboxylate anaerobic carrier TMEM37 PF15108.4 001163965.1_21022001_2 - 0.039 13.7 0.0 0.06 13.1 0.0 1.3 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family HPIH PF13323.4 001163965.1_21022001_2 - 0.11 12.3 0.0 0.41 10.4 0.0 1.8 2 0 0 2 2 2 0 N-terminal domain with HPIH motif DUF2628 PF10947.6 001163965.1_21022001_2 - 2.4 8.4 5.2 0.4 10.9 0.2 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2628) PAP2_C PF14360.4 001309200.1_21029001_1 - 1.1e-25 89.8 13.4 1.1e-25 89.8 13.4 2.2 2 0 0 2 2 2 1 PAP2 superfamily C-terminal PAP2 PF01569.19 001309200.1_21029001_1 - 6.4e-06 25.9 7.7 1.7e-05 24.5 7.7 1.8 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.4 001309200.1_21029001_1 - 0.33 10.5 13.0 0.057 13.0 8.4 2.0 2 0 0 2 2 2 0 PAP2 superfamily Paramyxo_PNT PF13825.4 001173081.1_09922001_1 - 6.6 5.9 7.8 8.1 5.6 7.8 1.1 1 0 0 1 1 1 0 Paramyxovirus structural protein V/P N-terminus Crystall PF00030.17 001173081.1_09922001_3 - 4e-67 222.3 2.4 1.3e-32 111.7 0.0 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 001173081.1_09922001_3 - 4.5e-05 23.2 0.3 0.022 14.5 1.0 2.3 2 0 0 2 2 2 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 001173081.1_09922001_3 - 0.065 13.3 0.1 1.6 8.8 0.0 2.7 2 1 1 3 3 3 0 Beta/Gamma crystallin Crystall PF00030.17 001173093.1_09922001_2 - 3.3e-63 209.8 2.7 5.1e-32 109.8 1.4 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 001173093.1_09922001_2 - 1.2e-05 25.0 0.0 0.011 15.5 0.6 2.4 2 0 0 2 2 2 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 001173093.1_09922001_2 - 0.06 13.4 0.3 0.88 9.6 0.0 2.3 1 1 1 2 2 2 0 Beta/Gamma crystallin 3Beta_HSD PF01073.17 001172878.2_09923001_3 - 3.5e-111 370.6 0.0 4.7e-111 370.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 001172878.2_09923001_3 - 2.7e-24 85.8 0.0 3.6e-24 85.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 001172878.2_09923001_3 - 1.7e-18 66.6 0.2 3.5e-18 65.6 0.2 1.5 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.3 001172878.2_09923001_3 - 8.9e-15 54.7 0.1 4.6e-14 52.4 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.4 001172878.2_09923001_3 - 1.6e-12 47.6 0.0 2.4e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.13 001172878.2_09923001_3 - 1.6e-11 43.8 0.4 2.7e-11 43.0 0.4 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.11 001172878.2_09923001_3 - 1.9e-07 30.7 0.2 3e-07 30.1 0.2 1.2 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.15 001172878.2_09923001_3 - 4e-07 29.3 0.0 5.6e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.8 001172878.2_09923001_3 - 2.2e-05 24.3 0.1 4.1e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 KR domain adh_short PF00106.23 001172878.2_09923001_3 - 0.016 14.6 0.3 0.03 13.6 0.3 1.5 1 1 0 1 1 1 0 short chain dehydrogenase Ldh_1_N PF00056.21 001172878.2_09923001_3 - 0.13 12.2 0.1 0.25 11.3 0.1 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain DapB_N PF01113.18 001172878.2_09923001_3 - 0.14 12.1 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Sushi PF00084.18 001172880.1_09925001_3 - 6.4e-37 125.8 17.1 1.4e-11 44.7 1.5 4.6 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) cEGF PF12662.5 001172880.1_09925001_3 - 0.3 10.9 8.0 21 5.1 0.3 4.3 4 0 0 4 4 4 0 Complement Clr-like EGF-like Actin PF00022.17 001172909.1_09924001_2 - 6.7e-151 502.4 0.0 1.7e-150 501.0 0.0 1.6 1 1 0 1 1 1 1 Actin 7tm_1 PF00001.19 001173085.1_09927001_1 - 6.6e-45 153.3 14.4 9.1e-45 152.8 14.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Rhodopsin_N PF10413.7 001173085.1_09927001_1 - 2.3e-23 81.6 2.7 2.3e-23 81.6 2.7 2.3 2 0 0 2 2 2 1 Amino terminal of the G-protein receptor rhodopsin 7TM_GPCR_Srv PF10323.7 001173085.1_09927001_1 - 1.1e-08 34.7 19.6 1.6e-08 34.1 19.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.7 001173085.1_09927001_1 - 1.5e-08 34.2 18.4 4.9e-08 32.5 18.4 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.7 001173085.1_09927001_1 - 2.3e-07 30.3 17.6 3.7e-07 29.6 17.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TAS2R PF05296.11 001173085.1_09927001_1 - 0.0025 16.8 11.5 0.005 15.9 3.1 2.1 2 0 0 2 2 2 2 Taste receptor protein (TAS2R) 7tm_4 PF13853.4 001173085.1_09927001_1 - 0.021 14.4 16.1 0.086 12.4 16.1 1.8 1 1 0 1 1 1 0 Olfactory receptor Sushi PF00084.18 001172881.1_09926001_3 - 7.5e-37 125.6 17.1 1.5e-11 44.6 1.5 4.6 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) cEGF PF12662.5 001172881.1_09926001_3 - 0.35 10.7 8.0 21 5.0 0.3 4.3 4 0 0 4 4 4 0 Complement Clr-like EGF-like Sushi PF00084.18 001172882.1_09925001_1 - 6.7e-37 125.8 17.1 1.4e-11 44.7 1.5 4.6 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) cEGF PF12662.5 001172882.1_09925001_1 - 0.3 10.9 8.0 21 5.0 0.3 4.4 4 0 0 4 4 4 0 Complement Clr-like EGF-like SKG6 PF08693.8 001172882.1_09925001_1 - 0.57 9.5 2.9 1.2 8.4 2.9 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain APS_kinase PF01583.18 001172995.1_09925001_2 - 1.2e-74 249.3 0.0 1.9e-74 248.7 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase ATP-sulfurylase PF01747.15 001172995.1_09925001_2 - 1.5e-69 233.6 0.1 2.1e-69 233.1 0.1 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.4 001172995.1_09925001_2 - 1.7e-48 164.1 0.0 2.6e-48 163.5 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.4 001172995.1_09925001_2 - 1e-07 32.1 0.0 2.1e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 001172995.1_09925001_2 - 9.7e-05 22.8 0.0 0.00047 20.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.15 001172995.1_09925001_2 - 0.077 12.5 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 Thymidylate kinase AAA_28 PF13521.4 001172995.1_09925001_2 - 0.1 12.7 0.0 0.67 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.15 001172995.1_09925001_2 - 0.21 11.2 0.1 0.4 10.3 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Sushi PF00084.18 001172883.1_09925001_3 - 6.7e-37 125.8 17.1 1.3e-11 44.8 1.5 4.4 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) cEGF PF12662.5 001172883.1_09925001_3 - 0.28 11.0 8.0 20 5.1 0.3 4.3 4 0 0 4 4 4 0 Complement Clr-like EGF-like Sushi PF00084.18 001172884.1_09923001_2 - 5.7e-38 129.2 17.1 6.9e-12 45.7 1.5 4.3 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) cEGF PF12662.5 001172884.1_09923001_2 - 0.035 13.9 8.0 12 5.9 0.3 4.5 4 0 0 4 4 4 0 Complement Clr-like EGF-like DUF1737 PF08410.8 001172884.1_09923001_2 - 0.15 11.8 0.0 2.3 8.0 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1737) Reprolysin PF01421.17 001173099.1_09925001_1 - 2.1e-55 187.6 0.3 4.4e-55 186.6 0.3 1.6 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 001173099.1_09925001_1 - 1.4e-22 80.1 5.9 1.4e-22 80.1 5.9 3.9 4 1 0 4 4 4 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 001173099.1_09925001_1 - 2e-20 73.3 0.1 3.8e-20 72.4 0.1 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.21 001173099.1_09925001_1 - 1.8e-19 70.2 30.0 1.8e-19 70.2 30.0 4.5 4 1 0 4 4 4 1 Disintegrin Reprolysin_5 PF13688.4 001173099.1_09925001_1 - 0.00076 19.5 0.0 0.0016 18.5 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 001173099.1_09925001_1 - 0.0067 16.8 0.0 0.013 15.9 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Sushi PF00084.18 001172885.1_09923001_1 - 4.3e-38 129.6 18.3 6e-12 45.9 1.5 4.7 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) cEGF PF12662.5 001172885.1_09923001_1 - 0.021 14.6 8.0 10 6.0 0.3 4.6 4 0 0 4 4 4 0 Complement Clr-like EGF-like DUF1737 PF08410.8 001172885.1_09923001_1 - 0.11 12.3 0.0 2 8.2 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1737) SKG6 PF08693.8 001172885.1_09923001_1 - 0.28 10.5 3.0 0.59 9.4 3.0 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Asp PF00026.21 001172999.1_09923001_1 - 7.7e-113 376.9 1.2 9.2e-113 376.7 1.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001172999.1_09923001_1 - 3.8e-16 59.7 6.8 1.7e-13 51.1 5.3 2.5 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001172999.1_09923001_1 - 4.8e-12 45.4 0.6 8.1e-12 44.6 0.6 1.4 1 0 0 1 1 1 1 A1 Propeptide TAXi_C PF14541.4 001172999.1_09923001_1 - 2.9e-05 23.8 0.0 0.0001 21.9 0.0 2.0 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.4 001172999.1_09923001_1 - 0.0081 16.7 0.0 0.99 10.0 0.0 2.6 2 1 0 2 2 2 1 Aspartyl protease Lipase PF00151.17 001173001.1_09924001_3 - 2.3e-163 543.2 0.0 2.7e-163 542.9 0.0 1.1 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 001173001.1_09924001_3 - 2.9e-17 63.2 0.1 5.6e-17 62.3 0.1 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.5 001173001.1_09924001_3 - 0.00067 20.2 0.2 0.0035 17.9 0.0 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 001173001.1_09924001_3 - 0.0059 16.1 0.1 0.0099 15.4 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 001173001.1_09924001_3 - 0.0068 15.6 0.0 0.0093 15.1 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF900 PF05990.10 001173001.1_09924001_3 - 0.099 12.0 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) 7tm_1 PF00001.19 001172921.1_09926001_2 - 5.1e-57 193.0 12.2 8.6e-57 192.3 12.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001172921.1_09926001_2 - 4.3e-09 36.0 13.2 1.1e-08 34.7 13.2 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.19 001172920.1_09923001_1 - 8.4e-55 185.7 20.5 1.3e-54 185.1 20.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2976 PF11190.6 001172920.1_09923001_1 - 0.16 11.6 3.6 1.1 8.9 0.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) Evr1_Alr PF04777.11 001173008.2_09925001_1 - 1.6e-27 95.8 0.9 6.6e-27 93.8 0.5 2.1 2 0 0 2 2 2 1 Erv1 / Alr family Thioredoxin PF00085.18 001173008.2_09925001_1 - 1e-16 60.6 0.0 1.4e-15 56.9 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.4 001173008.2_09925001_1 - 0.0017 18.5 0.0 0.011 15.9 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like Sushi PF00084.18 001172928.2_09923001_3 - 5.9e-38 129.1 19.4 2.8e-12 46.9 1.1 4.4 4 1 0 4 4 4 4 Sushi repeat (SCR repeat) SCIMP PF15050.4 001172928.2_09923001_3 - 0.034 14.5 0.4 0.068 13.5 0.4 1.4 1 0 0 1 1 1 0 SCIMP protein P12 PF12669.5 001172928.2_09923001_3 - 0.14 12.5 3.4 0.25 11.7 0.5 2.4 2 0 0 2 2 2 0 Virus attachment protein p12 family Hormone_6 PF00236.16 001172929.1_09922001_2 - 1e-49 166.3 11.2 1.6e-49 165.7 11.2 1.3 1 0 0 1 1 1 1 Glycoprotein hormone Hormone_1 PF00103.18 001195109.1_09922001_2 - 1.3e-66 224.3 1.0 1.5e-66 224.1 1.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family Hormone_1 PF00103.18 001195111.1_09922001_2 - 7.8e-49 166.2 0.6 9.3e-49 166.0 0.6 1.0 1 0 0 1 1 1 1 Somatotropin hormone family FAD_binding_8 PF08022.10 001195111.1_09922001_2 - 0.06 13.3 0.0 0.098 12.6 0.0 1.3 1 0 0 1 1 1 0 FAD-binding domain p450 PF00067.20 001173116.1_09925001_2 - 1.3e-129 432.9 2.4 1.5e-129 432.6 2.4 1.1 1 0 0 1 1 1 1 Cytochrome P450 Occludin_ELL PF07303.11 001199716.1_09924001_1 - 2.5e-26 92.2 10.1 4.2e-26 91.5 10.1 1.4 1 0 0 1 1 1 1 Occludin homology domain MARVEL PF01284.21 001199716.1_09924001_1 - 2.9e-25 88.9 12.2 3.8e-25 88.5 12.2 1.2 1 0 0 1 1 1 1 Membrane-associating domain UPF0182 PF03699.11 001199716.1_09924001_1 - 0.003 15.6 0.9 0.0054 14.8 0.6 1.4 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0182) IncA PF04156.12 001199716.1_09924001_1 - 0.011 15.4 3.3 0.011 15.4 3.3 3.8 4 1 0 4 4 2 0 IncA protein Laminin_II PF06009.10 001199716.1_09924001_1 - 0.013 15.3 0.7 0.022 14.6 0.7 1.2 1 0 0 1 1 1 0 Laminin Domain II PRKG1_interact PF15898.3 001199716.1_09924001_1 - 0.025 15.4 8.0 0.058 14.2 8.0 1.6 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain APG6 PF04111.10 001199716.1_09924001_1 - 0.027 13.7 4.6 0.039 13.2 4.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Spc7 PF08317.9 001199716.1_09924001_1 - 0.075 11.8 4.8 0.17 10.6 4.7 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein GAS PF13851.4 001199716.1_09924001_1 - 0.082 12.1 7.3 0.13 11.5 7.3 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding TMF_TATA_bd PF12325.6 001199716.1_09924001_1 - 0.088 12.9 3.2 0.16 12.1 3.2 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding CENP-H PF05837.10 001199716.1_09924001_1 - 0.29 11.4 1.6 0.5 10.7 1.6 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF342 PF03961.11 001199716.1_09924001_1 - 0.48 8.8 2.4 0.68 8.3 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF4164 PF13747.4 001199716.1_09924001_1 - 0.49 10.6 3.1 0.87 9.8 3.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) OmpH PF03938.12 001199716.1_09924001_1 - 0.85 9.5 6.6 1.5 8.7 6.6 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF2157 PF09925.7 001199716.1_09924001_1 - 1.8 8.2 8.5 0.43 10.2 3.8 2.3 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF4870 PF09685.8 001199716.1_09924001_1 - 1.9 8.5 8.5 64 3.6 8.5 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4870) SIT PF15330.4 001199716.1_09924001_1 - 2.3 8.5 0.0 2.3 8.5 0.0 3.2 4 0 0 4 4 3 0 SHP2-interacting transmembrane adaptor protein, SIT Swi5 PF07061.9 001199716.1_09924001_1 - 2.8 7.9 4.6 2.7 8.0 3.2 1.6 2 0 0 2 2 1 0 Swi5 TctB PF07331.9 001199716.1_09924001_1 - 6.9 6.8 11.2 30 4.7 8.8 2.4 2 1 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family Ank_2 PF12796.5 001198770.1_09927001_1 - 2.2e-77 255.6 26.6 1.2e-13 51.3 1.8 8.7 1 1 9 10 10 10 9 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001198770.1_09927001_1 - 4.1e-60 199.3 32.5 8.7e-09 35.6 0.1 11.7 4 3 8 13 13 13 12 Ankyrin repeats (many copies) Ank PF00023.28 001198770.1_09927001_1 - 5.8e-60 197.1 28.3 6.8e-08 32.5 0.0 14.7 15 0 0 15 15 15 12 Ankyrin repeat Ank_3 PF13606.4 001198770.1_09927001_1 - 3.6e-56 180.4 20.9 3.6e-05 23.7 0.0 15.8 16 0 0 16 16 16 12 Ankyrin repeat Ank_5 PF13857.4 001198770.1_09927001_1 - 5.3e-52 172.9 25.1 7.8e-08 32.3 0.8 12.6 3 3 8 12 12 12 11 Ankyrin repeats (many copies) Ion_trans PF00520.29 001198770.1_09927001_1 - 7.4e-12 44.9 22.0 1.2e-11 44.2 22.0 1.3 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.10 001198770.1_09927001_1 - 0.0027 16.3 22.8 0.0063 15.1 13.8 2.7 2 1 1 3 3 3 2 Polycystin cation channel Sacchrp_dh_NADP PF03435.16 001198770.1_09927001_1 - 0.049 13.8 0.1 25 5.0 0.0 3.5 3 0 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain SchA_CurD PF04486.10 001198770.1_09927001_1 - 0.091 12.7 3.2 0.75 9.8 0.0 3.5 5 0 0 5 5 5 0 SchA/CurD like domain Phtf-FEM1B_bdg PF12129.6 001198770.1_09927001_1 - 1.9 8.1 6.2 5.6 6.7 6.2 1.8 1 1 0 1 1 1 0 Male germ-cell putative homeodomain transcription factor Amelin PF05111.10 001173124.1_09924001_2 - 2.1e-190 633.1 39.8 1.5e-189 630.3 39.8 1.9 1 1 0 1 1 1 1 Ameloblastin precursor (Amelin) TIMP PF00965.15 001173024.1_09928001_3 - 1.2e-72 243.4 4.7 1.9e-72 242.7 4.7 1.4 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase LIN37 PF15306.4 001173024.1_09928001_3 - 0.11 12.5 0.1 0.21 11.7 0.1 1.3 1 0 0 1 1 1 0 LIN37 Ald_Xan_dh_C2 PF02738.16 001278780.1_09929001_2 - 1.3e-183 611.2 0.0 1.8e-183 610.8 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001278780.1_09929001_2 - 3.3e-38 131.0 0.0 6.6e-38 130.0 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 001278780.1_09929001_2 - 3.6e-30 104.4 2.0 7.3e-30 103.4 2.0 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 001278780.1_09929001_2 - 1.3e-28 98.6 0.2 3.1e-28 97.4 0.2 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 001278780.1_09929001_2 - 3.9e-27 94.3 0.0 8.8e-26 89.9 0.0 3.0 3 0 0 3 3 3 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001278780.1_09929001_2 - 2.9e-10 39.8 1.2 2.4e-09 36.9 0.1 2.9 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DUF218 PF02698.15 001278780.1_09929001_2 - 0.0043 16.9 0.0 0.015 15.2 0.0 1.9 2 0 0 2 2 2 1 DUF218 domain DHODB_Fe-S_bind PF10418.7 001278780.1_09929001_2 - 0.035 13.8 0.9 0.11 12.1 0.9 1.8 1 0 0 1 1 1 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B 7tm_1 PF00001.19 001172738.2_09924001_1 - 4.9e-59 199.6 28.4 7.4e-59 199.0 28.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001172738.2_09924001_1 - 7e-09 35.3 26.8 9.3e-09 34.9 26.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001172738.2_09924001_1 - 1.6e-05 24.3 27.6 2.7e-05 23.5 27.6 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001172738.2_09924001_1 - 0.0028 17.3 20.6 0.0057 16.3 20.6 1.5 1 1 0 1 1 1 1 Olfactory receptor GILT PF03227.14 001288790.1_09922001_1 - 1.1e-28 99.4 0.5 1.6e-28 98.9 0.5 1.3 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) p450 PF00067.20 001278754.1_09923001_1 - 1.1e-162 541.9 0.1 1.3e-162 541.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ald_Xan_dh_C2 PF02738.16 001308442.1_09929001_2 - 7e-183 608.9 0.3 9.3e-183 608.5 0.3 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001308442.1_09929001_2 - 4.6e-45 153.3 0.0 9.1e-45 152.3 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Fer2_2 PF01799.18 001308442.1_09929001_2 - 4e-31 106.7 0.1 1e-30 105.4 0.1 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain Ald_Xan_dh_C PF01315.20 001308442.1_09929001_2 - 6.4e-29 100.4 0.2 1.1e-28 99.6 0.2 1.4 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.15 001308442.1_09929001_2 - 1.5e-26 92.4 0.0 5.5e-26 90.6 0.0 2.1 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001308442.1_09929001_2 - 4.5e-10 39.2 0.5 2.5e-09 36.8 0.5 2.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Filament PF00038.19 001173040.1_09924001_2 - 1.4e-113 379.4 51.7 1.8e-113 379.1 51.7 1.1 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.12 001173040.1_09924001_2 - 1.1e-18 67.8 20.9 2e-18 66.9 19.7 2.1 2 1 0 2 2 1 1 Intermediate filament head (DNA binding) region Reo_sigmaC PF04582.10 001173040.1_09924001_2 - 0.00025 20.4 7.8 0.034 13.4 0.6 3.2 1 1 3 4 4 4 3 Reovirus sigma C capsid protein DUF1664 PF07889.10 001173040.1_09924001_2 - 0.0033 17.3 25.2 0.0042 16.9 1.7 4.0 3 1 2 5 5 5 2 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.10 001173040.1_09924001_2 - 0.044 13.7 53.3 0.14 12.1 13.7 4.3 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein DUF4515 PF14988.4 001173040.1_09924001_2 - 0.071 12.8 46.3 0.076 12.7 31.9 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4515) Jnk-SapK_ap_N PF09744.7 001173040.1_09924001_2 - 0.092 12.8 46.7 0.18 11.9 19.2 3.8 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Golgin_A5 PF09787.7 001173040.1_09924001_2 - 0.1 11.9 44.2 0.49 9.7 23.7 2.4 1 1 1 2 2 2 0 Golgin subfamily A member 5 IncA PF04156.12 001173040.1_09924001_2 - 0.15 11.7 54.4 1.1 8.9 5.7 4.2 1 1 3 4 4 4 0 IncA protein MdcG PF10620.7 001173040.1_09924001_2 - 0.16 11.6 2.5 0.14 11.7 0.8 1.8 2 0 0 2 2 2 0 Phosphoribosyl-dephospho-CoA transferase MdcG DUF573 PF04504.12 001173040.1_09924001_2 - 0.16 12.5 9.8 0.68 10.5 0.7 3.5 2 2 1 3 3 3 0 Protein of unknown function, DUF573 bZIP_1 PF00170.19 001173040.1_09924001_2 - 0.2 11.6 28.6 7 6.7 1.9 6.0 4 1 1 5 5 5 0 bZIP transcription factor Laminin_II PF06009.10 001173040.1_09924001_2 - 0.44 10.4 27.1 1.1 9.1 8.1 3.6 2 2 1 3 3 3 0 Laminin Domain II Atg14 PF10186.7 001173040.1_09924001_2 - 0.84 8.5 28.4 1.6 7.6 13.3 2.3 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Baculo_PEP_C PF04513.10 001173040.1_09924001_2 - 0.87 9.5 20.3 0.97 9.3 1.9 4.5 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HALZ PF02183.16 001173040.1_09924001_2 - 1.3 9.1 31.9 0.11 12.6 2.1 6.3 6 1 0 6 6 6 0 Homeobox associated leucine zipper CALCOCO1 PF07888.9 001173040.1_09924001_2 - 1.9 6.9 43.5 0.48 8.8 31.0 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like CENP-F_leu_zip PF10473.7 001173040.1_09924001_2 - 3.9 7.4 45.8 0.19 11.6 9.1 3.6 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.4 001173040.1_09924001_2 - 4.3 6.5 48.0 0.39 9.9 15.1 3.6 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.9 001173040.1_09924001_2 - 9.3 4.9 46.5 2.8 6.6 13.7 2.9 1 1 2 3 3 3 0 Spc7 kinetochore protein GnRH PF00446.15 001172956.1_09922001_2 - 0.036 14.3 1.3 0.036 14.3 1.3 2.0 2 0 0 2 2 2 0 Gonadotropin-releasing hormone Rdx PF10262.7 001257969.1_09921001_1 - 4.2e-05 23.5 0.0 5.5e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Rdx family Serpin PF00079.18 001173045.1_09923001_1 - 2.5e-129 431.7 5.4 2.8e-129 431.5 5.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF4998 PF16389.3 001173045.1_09923001_1 - 0.0053 16.2 0.1 0.0085 15.6 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function EF-hand_1 PF00036.30 001252431.2_09923001_3 - 1.5e-41 136.7 9.6 1.5e-09 36.5 0.4 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 001252431.2_09923001_3 - 1.9e-35 121.0 2.7 2.8e-18 66.0 0.7 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 001252431.2_09923001_3 - 4.6e-33 112.6 9.7 2.2e-14 52.8 0.3 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.4 001252431.2_09923001_3 - 2.2e-29 98.8 5.5 4e-09 35.6 0.1 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.4 001252431.2_09923001_3 - 5.9e-26 88.7 6.9 3.1e-06 26.3 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.4 001252431.2_09923001_3 - 1.8e-14 53.7 0.2 1.2e-08 35.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 001252431.2_09923001_3 - 5.6e-09 35.8 0.2 0.00028 20.7 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 001252431.2_09923001_3 - 6.3e-07 29.6 0.0 0.021 15.0 0.0 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.9 001252431.2_09923001_3 - 4.4e-05 24.2 0.0 0.0049 17.6 0.0 2.2 1 1 1 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.8 001252431.2_09923001_3 - 0.00013 21.9 0.7 0.00042 20.2 0.1 2.2 2 0 0 2 2 2 1 Ca2+ insensitive EF hand UPF0154 PF03672.11 001252431.2_09923001_3 - 0.00022 21.0 0.0 0.15 12.0 0.0 3.1 2 1 1 3 3 3 1 Uncharacterised protein family (UPF0154) DUF4497 PF14924.4 001252431.2_09923001_3 - 0.0043 17.3 0.0 4.1 7.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF4497) DUF1103 PF06513.9 001252431.2_09923001_3 - 0.009 15.5 2.0 0.012 15.1 2.0 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) Caleosin PF05042.11 001252431.2_09923001_3 - 0.023 14.5 0.3 1.8 8.3 0.0 3.0 1 1 3 4 4 4 0 Caleosin related protein DUF3349 PF11829.6 001252431.2_09923001_3 - 0.026 15.2 0.3 5.8 7.6 0.0 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) RNA_pol_Rpb4 PF03874.14 001252431.2_09923001_3 - 0.036 14.3 0.2 5.7 7.2 0.1 2.4 2 0 0 2 2 2 0 RNA polymerase Rpb4 TerB PF05099.11 001252431.2_09923001_3 - 0.04 13.7 0.4 3.4 7.5 0.0 2.3 1 1 1 2 2 2 0 Tellurite resistance protein TerB GPHH PF16905.3 001252431.2_09923001_3 - 0.098 12.3 0.0 0.61 9.8 0.0 2.3 3 0 0 3 3 2 0 Voltage-dependent L-type calcium channel, IQ-associated DUF2267 PF10025.7 001252431.2_09923001_3 - 0.11 12.7 0.0 0.3 11.2 0.0 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) SurA_N_2 PF13623.4 001252431.2_09923001_3 - 0.12 12.1 0.8 2.2 8.0 0.2 2.2 1 1 1 2 2 2 0 SurA N-terminal domain 7tm_1 PF00001.19 001172962.2_09923001_2 - 5.8e-64 215.8 11.2 7.6e-64 215.4 11.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001172962.2_09923001_2 - 5.1e-11 42.3 13.3 3.7e-10 39.5 13.3 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001172962.2_09923001_2 - 9.8e-06 25.0 13.8 9.9e-05 21.7 13.8 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001172962.2_09923001_2 - 3e-05 23.8 9.3 4.3e-05 23.3 6.7 2.1 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001172962.2_09923001_2 - 0.00029 20.1 6.7 0.00029 20.1 6.7 2.5 3 0 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF1385 PF07136.9 001172962.2_09923001_2 - 0.079 12.1 0.0 0.079 12.1 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1385) bZIP_Maf PF03131.15 001173050.1_09923001_3 - 1.3e-30 105.6 11.5 1.9e-30 105.1 11.5 1.2 1 0 0 1 1 1 1 bZIP Maf transcription factor Maf_N PF08383.9 001173050.1_09923001_3 - 3.3e-16 58.6 3.2 6e-16 57.8 3.2 1.4 1 0 0 1 1 1 1 Maf N-terminal region bZIP_1 PF00170.19 001173050.1_09923001_3 - 0.027 14.4 12.6 0.043 13.8 12.6 1.3 1 0 0 1 1 1 0 bZIP transcription factor DivIC PF04977.13 001173050.1_09923001_3 - 0.029 14.0 0.8 0.029 14.0 0.8 1.5 2 0 0 2 2 2 0 Septum formation initiator KASH_CCD PF14662.4 001173050.1_09923001_3 - 0.1 12.3 0.1 0.16 11.7 0.1 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DUF4407 PF14362.4 001173050.1_09923001_3 - 0.14 11.4 2.9 0.19 10.9 2.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4164 PF13747.4 001173050.1_09923001_3 - 0.28 11.4 7.2 0.52 10.5 7.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) bZIP_2 PF07716.13 001173050.1_09923001_3 - 0.33 10.9 16.7 0.097 12.6 13.9 1.6 2 0 0 2 2 2 0 Basic region leucine zipper Calc_CGRP_IAPP PF00214.17 001172965.2_09921001_1 - 5.8e-14 52.4 2.3 1.2e-13 51.3 1.7 1.7 1 1 1 2 2 2 1 Calcitonin / CGRP / IAPP family IL12 PF03039.12 001172840.1_09922001_1 - 1.6e-112 374.0 6.6 1.8e-112 373.9 6.6 1.0 1 0 0 1 1 1 1 Interleukin-12 alpha subunit DUF1139 PF06599.9 001172840.1_09922001_1 - 0.062 12.6 0.2 0.093 12.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1139) Pyr_redox_2 PF07992.12 001256474.1_09924001_3 - 8.8e-62 208.8 0.0 1.2e-61 208.4 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 001256474.1_09924001_3 - 8.3e-29 99.9 0.0 1.5e-28 99.1 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 001256474.1_09924001_3 - 1.9e-19 69.8 0.1 3.1e-14 53.2 0.0 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001256474.1_09924001_3 - 7.3e-10 38.4 0.1 2.2e-05 23.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 001256474.1_09924001_3 - 2.2e-09 36.8 4.8 3.8e-07 29.4 1.2 3.2 2 1 0 3 3 3 1 FAD binding domain AlaDh_PNT_C PF01262.19 001256474.1_09924001_3 - 2.6e-05 23.5 0.5 0.0012 18.0 0.4 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.20 001256474.1_09924001_3 - 6e-05 22.2 1.4 0.00036 19.6 1.4 2.0 1 1 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.12 001256474.1_09924001_3 - 9.1e-05 21.2 0.3 0.00048 18.8 0.2 1.9 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.5 001256474.1_09924001_3 - 0.00012 21.4 0.4 0.00018 20.9 0.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase K_oxygenase PF13434.4 001256474.1_09924001_3 - 0.00046 19.3 0.1 0.0023 17.0 0.0 2.0 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.22 001256474.1_09924001_3 - 0.0011 18.5 2.4 0.0031 17.1 1.8 2.0 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.4 001256474.1_09924001_3 - 0.0072 16.4 0.5 0.0072 16.4 0.5 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.4 001256474.1_09924001_3 - 0.014 15.7 0.0 4.4 7.7 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding Thi4 PF01946.15 001256474.1_09924001_3 - 0.023 13.8 0.1 0.023 13.8 0.1 1.6 2 0 0 2 2 2 0 Thi4 family Lycopene_cycl PF05834.10 001256474.1_09924001_3 - 0.076 11.9 0.5 0.13 11.2 0.5 1.4 1 1 0 1 1 1 0 Lycopene cyclase protein XdhC_C PF13478.4 001256474.1_09924001_3 - 0.16 12.4 0.1 5.5 7.4 0.0 2.4 2 0 0 2 2 2 0 XdhC Rossmann domain 7tm_1 PF00001.19 001173056.1_09925001_2 - 5e-34 117.6 9.6 6.9e-34 117.2 9.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001173056.1_09925001_2 - 8.8e-06 25.1 7.2 1.4e-05 24.4 7.2 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx NdhL PF10716.7 001173056.1_09925001_2 - 0.043 13.7 0.0 0.043 13.7 0.0 2.5 3 0 0 3 3 3 0 NADH dehydrogenase transmembrane subunit ECF_trnsprt PF12822.5 001173056.1_09925001_2 - 3.2 7.6 9.8 0.72 9.8 4.3 2.1 2 0 0 2 2 2 0 ECF transporter, substrate-specific component TMEM125 PF15109.4 001173056.1_09925001_2 - 3.7 7.8 6.5 5.4 7.3 0.4 3.4 3 1 0 3 3 3 0 TMEM125 protein family Defensin_propep PF00879.16 001173057.1_09921001_1 - 2.1e-18 66.2 0.1 2.8e-18 65.9 0.1 1.1 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001173057.1_09921001_1 - 1.3e-08 35.1 15.7 2.6e-08 34.1 15.7 1.5 1 0 0 1 1 1 1 Mammalian defensin Mito_carr PF00153.25 001278766.1_09924001_2 - 2.3e-59 197.2 1.0 2.5e-23 81.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_S7e PF01251.16 001286001.1_09922001_3 - 1.3e-93 311.8 3.8 1.5e-93 311.6 3.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Pkinase_Tyr PF07714.15 001172971.1_09924001_2 - 2.3e-38 131.8 0.0 3.6e-38 131.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_5 PF13857.4 001172971.1_09924001_2 - 3.5e-23 81.2 1.3 2.4e-10 40.3 0.2 3.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 001172971.1_09924001_2 - 7.4e-23 80.5 2.5 5.4e-10 39.5 0.1 4.2 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Pkinase PF00069.23 001172971.1_09924001_2 - 6e-22 78.1 0.0 1e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.5 001172971.1_09924001_2 - 1.4e-20 73.5 0.1 1.6e-10 41.3 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 001172971.1_09924001_2 - 6.3e-20 70.6 0.2 5e-06 26.6 0.1 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.4 001172971.1_09924001_2 - 3.1e-18 63.8 0.2 5.1e-06 26.3 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat Serpin PF00079.18 001173060.1_09923001_1 - 6.7e-81 272.3 0.0 7.7e-81 272.1 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Ion_trans PF00520.29 001172973.1_09928001_1 - 1.4e-35 122.6 3.5 1.9e-35 122.1 3.5 1.2 1 0 0 1 1 1 1 Ion transport protein PAS_9 PF13426.5 001172973.1_09928001_1 - 3.5e-17 62.4 0.0 7.3e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 PAS domain cNMP_binding PF00027.27 001172973.1_09928001_1 - 8.1e-12 44.9 0.0 2e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.14 001172973.1_09928001_1 - 2e-11 43.6 0.3 2e-11 43.6 0.3 2.0 2 0 0 2 2 2 1 Ion channel PAS PF00989.23 001172973.1_09928001_1 - 1.2e-08 34.7 0.0 4.2e-08 33.1 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.10 001172973.1_09928001_1 - 1.7e-06 28.1 0.0 3.5e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.8 001172973.1_09928001_1 - 8.9e-05 22.6 0.0 0.0013 18.9 0.0 2.7 3 0 0 3 3 3 1 PAS fold PAS_8 PF13188.5 001172973.1_09928001_1 - 0.0064 16.3 0.0 0.019 14.8 0.0 1.8 1 0 0 1 1 1 1 PAS domain Ion_trans_2 PF07885.14 001172977.1_09923001_1 - 8.5e-37 124.9 16.3 1.9e-18 66.0 0.2 2.8 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.29 001172977.1_09923001_1 - 7.5e-08 31.8 2.5 0.028 13.5 5.4 2.2 1 1 1 2 2 2 2 Ion transport protein DUF2101 PF09874.7 001172977.1_09923001_1 - 2.8 7.5 5.8 21 4.6 0.1 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2101) ABC_membrane PF00664.21 001278770.1_09928001_1 - 1.7e-170 565.6 24.6 1.4e-93 313.4 5.8 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001278770.1_09928001_1 - 9.4e-77 256.0 1.5 2.3e-38 131.7 0.1 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 001278770.1_09928001_1 - 1.1e-15 57.5 5.8 4.7e-07 29.3 1.4 3.7 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 001278770.1_09928001_1 - 1.3e-11 45.1 1.2 0.00018 21.8 0.1 2.8 2 1 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.7 001278770.1_09928001_1 - 4.6e-09 35.4 1.0 0.0006 18.6 0.0 2.8 3 0 0 3 3 3 2 Predicted ATPase of the ABC class G-alpha PF00503.18 001278770.1_09928001_1 - 2.5e-08 33.4 0.2 0.0032 16.5 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit DUF258 PF03193.14 001278770.1_09928001_1 - 9.2e-08 32.0 0.2 0.0055 16.5 0.1 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.4 001278770.1_09928001_1 - 9.7e-08 32.3 3.5 0.0095 16.1 0.1 3.4 2 2 0 2 2 2 2 AAA domain Zeta_toxin PF06414.10 001278770.1_09928001_1 - 1.2e-07 31.1 1.2 0.00077 18.7 0.0 3.4 4 0 0 4 4 4 2 Zeta toxin Rad17 PF03215.13 001278770.1_09928001_1 - 3e-06 26.3 0.0 0.033 13.0 0.0 2.3 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_5 PF07728.12 001278770.1_09928001_1 - 3.5e-06 26.9 0.5 0.049 13.5 0.0 3.6 4 0 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA_29 PF13555.4 001278770.1_09928001_1 - 1.2e-05 24.8 2.0 0.056 13.0 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA PF00004.27 001278770.1_09928001_1 - 2.7e-05 24.4 4.7 0.26 11.6 0.2 4.3 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.4 001278770.1_09928001_1 - 3e-05 23.7 0.0 0.18 11.3 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain SbcCD_C PF13558.4 001278770.1_09928001_1 - 0.00011 22.3 2.7 0.28 11.3 0.2 3.7 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_28 PF13521.4 001278770.1_09928001_1 - 0.00013 22.2 1.2 1.5 8.9 0.1 3.5 2 2 1 3 3 3 2 AAA domain AAA_30 PF13604.4 001278770.1_09928001_1 - 0.00014 21.5 2.9 0.13 11.8 0.2 3.0 2 2 0 2 2 2 2 AAA domain DUF87 PF01935.15 001278770.1_09928001_1 - 0.00018 21.5 1.8 0.7 9.7 0.0 3.1 3 0 0 3 3 3 2 Domain of unknown function DUF87 AAA_21 PF13304.4 001278770.1_09928001_1 - 0.00069 19.4 0.1 14 5.2 0.0 4.2 3 1 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF815 PF05673.11 001278770.1_09928001_1 - 0.00086 18.4 0.1 0.51 9.3 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) PRK PF00485.16 001278770.1_09928001_1 - 0.0011 18.6 0.0 1.4 8.5 0.0 2.4 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family APS_kinase PF01583.18 001278770.1_09928001_1 - 0.0017 18.2 0.3 0.26 11.0 0.1 2.6 2 0 0 2 2 2 1 Adenylylsulphate kinase ATP-synt_ab PF00006.23 001278770.1_09928001_1 - 0.0022 17.6 1.5 1.8 8.0 0.0 3.1 2 1 0 3 3 3 1 ATP synthase alpha/beta family, nucleotide-binding domain RNA_helicase PF00910.20 001278770.1_09928001_1 - 0.0023 18.2 0.0 3.7 7.8 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_24 PF13479.4 001278770.1_09928001_1 - 0.0037 16.9 0.1 1.5 8.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.4 001278770.1_09928001_1 - 0.0056 17.1 0.0 3.3 8.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.4 001278770.1_09928001_1 - 0.011 15.8 0.0 7.1 6.6 0.0 3.0 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.15 001278770.1_09928001_1 - 0.011 15.3 1.6 27 4.3 0.0 4.1 4 0 0 4 4 4 0 IstB-like ATP binding protein tRNA_lig_kinase PF08303.9 001278770.1_09928001_1 - 0.021 14.8 0.0 3.8 7.4 0.0 2.6 2 0 0 2 2 2 0 tRNA ligase kinase domain NACHT PF05729.10 001278770.1_09928001_1 - 0.025 14.4 0.3 4.1 7.2 0.0 2.5 2 0 0 2 2 2 0 NACHT domain Mg_chelatase PF01078.19 001278770.1_09928001_1 - 0.029 13.6 0.0 7.5 5.7 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AIG1 PF04548.14 001278770.1_09928001_1 - 0.057 12.6 0.1 12 5.0 0.1 2.5 2 0 0 2 2 2 0 AIG1 family AAA_25 PF13481.4 001278770.1_09928001_1 - 0.058 12.8 0.1 11 5.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain Peptidase_M23 PF01551.20 001278770.1_09928001_1 - 0.1 12.7 0.3 28 4.9 0.0 3.2 3 0 0 3 3 2 0 Peptidase family M23 MMR_HSR1 PF01926.21 001278770.1_09928001_1 - 0.11 12.5 0.1 9.8 6.2 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase Dala_Dala_lig_N PF01820.19 001278770.1_09928001_1 - 0.16 12.0 0.4 2.1 8.4 0.0 2.9 3 0 0 3 3 3 0 D-ala D-ala ligase N-terminus PduV-EutP PF10662.7 001278770.1_09928001_1 - 0.17 11.5 0.7 15 5.2 0.1 3.0 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.13 001278770.1_09928001_1 - 0.26 11.0 3.2 0.71 9.6 0.2 2.7 3 0 0 3 3 3 0 NTPase TNF PF00229.16 001311078.1_09922001_1 - 2.9e-46 156.4 1.7 4.8e-46 155.7 1.7 1.4 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 001311078.1_09922001_1 - 0.0096 16.0 2.2 0.52 10.4 0.2 2.4 1 1 1 2 2 2 2 C1q domain Hormone_1 PF00103.18 001172859.1_09922001_1 - 1.2e-44 152.5 0.0 1.7e-44 152.1 0.0 1.1 1 0 0 1 1 1 1 Somatotropin hormone family MIP PF00230.18 001172983.1_09923001_2 - 1.6e-79 266.6 14.2 2e-79 266.4 14.2 1.0 1 0 0 1 1 1 1 Major intrinsic protein GCR PF02155.13 001172987.1_09925001_1 - 7.7e-173 574.6 6.4 9.8e-173 574.3 6.4 1.1 1 0 0 1 1 1 1 Glucocorticoid receptor Hormone_recep PF00104.28 001172987.1_09925001_1 - 2.4e-30 105.5 4.2 1.3e-29 103.1 3.1 2.1 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001172987.1_09925001_1 - 2.2e-27 95.1 11.8 4.1e-27 94.3 11.8 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) zf-P11 PF03854.12 001172987.1_09925001_1 - 5.5 6.6 7.5 13 5.4 4.2 2.6 2 0 0 2 2 2 0 P-11 zinc finger Humanin PF15040.4 001193629.2_39723001_2 - 7.3e-17 60.4 1.3 1.3e-16 59.6 1.3 1.5 1 0 0 1 1 1 1 Humanin family Humanin PF15040.4 001193634.1_39724001_2 - 1.3e-14 53.2 0.3 2.3e-14 52.4 0.3 1.4 1 0 0 1 1 1 1 Humanin family Humanin PF15040.4 001195028.1_29623001_2 - 5e-13 48.2 1.2 1.1e-12 47.1 1.2 1.6 1 0 0 1 1 1 1 Humanin family Humanin PF15040.4 001195085.1_29624001_2 - 1.8e-16 59.2 1.0 3.2e-16 58.4 1.0 1.4 1 0 0 1 1 1 1 Humanin family Humanin PF15040.4 001193627.1_39724001_1 - 2.2e-15 55.7 0.9 3.7e-15 55.0 0.9 1.4 1 0 0 1 1 1 1 Humanin family Humanin PF15040.4 001193606.1_39724001_3 - 2.1e-15 55.8 2.2 3.7e-15 55.0 2.2 1.4 1 0 0 1 1 1 1 Humanin family DZR PF12773.5 046398.2_26227120_1 - 2.4 8.1 5.8 6.7 6.7 5.8 1.8 1 0 0 1 1 1 0 Double zinc ribbon DUF1725 PF08333.9 046398.2_26227120_2 - 8.1e-06 25.2 0.9 2.1e-05 23.9 0.9 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) RVT_1 PF00078.25 046398.2_26227120_2 - 1.1e-05 25.0 0.1 2.3e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CpG_bind_C PF12269.6 046398.2_26227120_3 - 0.13 11.8 4.9 2.2 7.8 3.1 2.5 1 1 1 2 2 2 0 CpG binding protein zinc finger C terminal domain zf-C2H2_assoc3 PF16637.3 102353.1_45724120_1 - 4.9e-29 100.4 5.8 4.9e-29 100.4 5.8 1.7 2 0 0 2 2 2 1 Putative zinc-finger between two C2H2 zinc-fingers on Patz zf-C2H2_6 PF13912.4 102353.1_45724120_1 - 8.4e-06 25.5 2.0 8.4e-06 25.5 2.0 4.8 5 0 0 5 5 5 1 C2H2-type zinc finger zf-H2C2_2 PF13465.4 102353.1_45724120_1 - 6.1e-05 23.1 1.5 6.1e-05 23.1 1.5 5.2 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.24 102353.1_45724120_1 - 7.7e-05 22.8 28.2 0.0001 22.4 0.8 5.2 5 0 0 5 5 5 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 102353.1_45724120_1 - 0.0008 19.9 29.8 0.0035 17.9 0.8 5.3 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_11 PF16622.3 102353.1_45724120_1 - 0.13 12.0 5.3 0.46 10.1 0.1 2.9 2 0 0 2 2 2 0 zinc-finger C2H2-type ARS2 PF04959.11 102353.1_45724120_1 - 0.13 12.4 0.1 0.13 12.4 0.1 1.6 2 0 0 2 2 2 0 Arsenite-resistance protein 2 GAGA PF09237.9 102353.1_45724120_1 - 0.21 11.3 3.4 8.6 6.1 1.0 2.7 3 0 0 3 3 3 0 GAGA factor zf-C2H2_jaz PF12171.6 102353.1_45724120_1 - 0.41 10.9 10.6 1.6 9.0 0.1 4.3 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 102353.1_45724120_1 - 3.6 7.7 12.5 3.3 7.8 0.4 3.2 3 0 0 3 3 3 0 Zinc ribbon domain E1-E2_ATPase PF00122.18 027839.1_45729120_3 - 1.3e-64 217.4 2.7 4.8e-64 215.6 1.3 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 027839.1_45729120_3 - 4.5e-46 156.7 2.2 1e-45 155.6 2.2 1.7 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 027839.1_45729120_3 - 6.5e-21 74.1 0.5 1.1e-20 73.4 0.5 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 027839.1_45729120_3 - 2.9e-17 63.5 0.0 2e-16 60.8 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 027839.1_45729120_3 - 1.9e-16 59.3 0.9 7e-16 57.5 0.1 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 027839.1_45729120_3 - 3.3e-05 23.6 0.5 6.4e-05 22.7 0.5 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 027839.1_45729120_3 - 0.00068 19.9 0.0 0.0022 18.3 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase ARID PF01388.19 033310.1_32929120_1 - 1.7e-07 31.7 0.0 3.4e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain zf-H2C2_2 PF13465.4 102354.1_45723120_1 - 0.054 13.8 1.6 0.054 13.8 1.6 1.9 2 0 0 2 2 2 0 Zinc-finger double domain Pkinase_Tyr PF07714.15 138102.1_32926120_2 - 6.1e-44 150.1 0.0 7.8e-44 149.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 138102.1_32926120_2 - 8.7e-42 143.2 0.0 1.2e-41 142.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain CARD PF00619.19 138102.1_32926120_3 - 1e-18 67.0 0.4 1.6e-18 66.4 0.4 1.3 1 0 0 1 1 1 1 Caspase recruitment domain DNA_RNApol_7kD PF03604.11 138102.1_32926120_3 - 0.017 14.7 0.8 0.061 12.9 0.8 2.0 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit CD225 PF04505.10 077057.1_45723120_3 - 2e-07 30.9 1.2 3e-07 30.4 0.2 1.9 2 0 0 2 2 2 1 Interferon-induced transmembrane protein ubiquitin PF00240.21 027064.3_26228120_3 - 0.0004 19.9 0.0 0.00061 19.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Myosin_tail_1 PF01576.17 015344.1_21022120_1 - 1.9e-09 35.8 14.4 2.3e-09 35.6 14.4 1.0 1 0 0 1 1 1 1 Myosin tail Alanine_zipper PF11839.6 015344.1_21022120_1 - 0.0001 22.4 4.4 0.0013 18.8 4.4 2.0 1 1 0 1 1 1 1 Alanine-zipper, major outer membrane lipoprotein Tropomyosin PF00261.18 015344.1_21022120_1 - 0.0048 16.2 17.6 0.047 12.9 7.9 2.0 1 1 1 2 2 2 2 Tropomyosin DUF3635 PF12330.6 015344.1_21022120_1 - 0.0048 17.3 0.9 0.0068 16.8 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3635) GAT PF03127.12 015344.1_21022120_1 - 0.0091 16.2 1.7 0.017 15.3 1.7 1.4 1 0 0 1 1 1 1 GAT domain Rootletin PF15035.4 015344.1_21022120_1 - 0.017 15.1 13.3 0.07 13.1 7.0 2.5 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF3573 PF12097.6 015344.1_21022120_1 - 0.024 13.4 1.1 0.027 13.2 1.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) APG6 PF04111.10 015344.1_21022120_1 - 0.066 12.5 10.1 0.08 12.2 10.1 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF724 PF05266.12 015344.1_21022120_1 - 0.073 12.8 10.9 0.089 12.5 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) ISG65-75 PF11727.6 015344.1_21022120_1 - 0.094 11.8 8.3 0.12 11.5 8.3 1.0 1 0 0 1 1 1 0 Invariant surface glycoprotein Noelin-1 PF12308.6 015344.1_21022120_1 - 0.33 10.8 4.4 0.28 11.0 3.0 1.6 1 1 1 2 2 2 0 Neurogenesis glycoprotein DUF2203 PF09969.7 015344.1_21022120_1 - 0.35 11.4 4.7 0.51 10.9 4.7 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) SlyX PF04102.10 015344.1_21022120_1 - 0.54 10.8 8.8 16 6.1 0.1 3.0 1 1 1 2 2 2 0 SlyX DUF4337 PF14235.4 015344.1_21022120_1 - 0.6 10.1 5.8 0.85 9.6 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) YtxH PF12732.5 015344.1_21022120_1 - 0.76 10.2 4.6 12 6.4 4.6 2.1 1 1 0 1 1 1 0 YtxH-like protein DUF1664 PF07889.10 015344.1_21022120_1 - 1 9.2 6.3 1.1 9.1 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) OEP PF02321.16 015344.1_21022120_1 - 1.4 8.6 7.8 1.9 8.1 7.8 1.1 1 0 0 1 1 1 0 Outer membrane efflux protein DUF342 PF03961.11 015344.1_21022120_1 - 1.5 7.2 9.1 1.7 7.0 9.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF948 PF06103.9 015344.1_21022120_1 - 1.9 8.7 4.4 25 5.1 4.2 2.2 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) XhlA PF10779.7 015344.1_21022120_1 - 2.9 8.0 10.3 3.3 7.8 4.1 2.6 1 1 1 2 2 2 0 Haemolysin XhlA IncA PF04156.12 015344.1_21022120_1 - 4.9 6.8 15.2 1.9 8.1 3.8 2.0 1 1 1 2 2 2 0 IncA protein Synaptobrevin PF00957.19 015344.1_21022120_1 - 5.9 6.6 7.3 1.6 8.5 3.3 1.9 1 1 1 2 2 2 0 Synaptobrevin Myosin_tail_1 PF01576.17 015344.1_21022120_3 - 1.3e-07 29.8 14.7 1.5e-07 29.6 14.7 1.0 1 0 0 1 1 1 1 Myosin tail Bacillus_HBL PF05791.9 015344.1_21022120_3 - 0.0097 15.5 2.8 0.013 15.1 2.8 1.1 1 0 0 1 1 1 1 Bacillus haemolytic enterotoxin (HBL) LUC7 PF03194.13 015344.1_21022120_3 - 0.021 14.3 4.2 0.024 14.1 4.2 1.1 1 0 0 1 1 1 0 LUC7 N_terminus Apolipoprotein PF01442.16 015344.1_21022120_3 - 0.063 13.1 11.9 0.082 12.7 11.9 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain BLOC1_2 PF10046.7 015344.1_21022120_3 - 0.072 13.3 4.9 0.14 12.4 4.9 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.10 015344.1_21022120_3 - 0.11 12.4 5.4 0.15 11.9 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) BRI3BP PF14965.4 015344.1_21022120_3 - 0.14 11.5 6.9 1.9 7.9 0.9 2.1 2 0 0 2 2 2 0 Negative regulator of p53/TP53 FlxA PF14282.4 015344.1_21022120_3 - 0.2 11.5 9.6 0.38 10.6 9.6 1.4 1 0 0 1 1 1 0 FlxA-like protein ALMT PF11744.6 015344.1_21022120_3 - 0.5 9.0 7.6 0.67 8.6 7.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Trimer_CC PF08954.9 015344.1_21022120_3 - 0.51 9.8 13.6 0.075 12.5 4.0 2.3 2 0 0 2 2 2 0 Trimerisation motif GreA_GreB_N PF03449.13 015344.1_21022120_3 - 0.59 10.2 10.3 0.99 9.5 10.3 1.4 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal Tropomyosin_1 PF12718.5 015344.1_21022120_3 - 0.68 9.9 18.0 1.2 9.1 18.0 1.4 1 1 0 1 1 1 0 Tropomyosin like BshC PF10079.7 015344.1_21022120_3 - 0.71 8.4 9.7 0.87 8.1 9.7 1.0 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC Exonuc_VII_L PF02601.13 015344.1_21022120_3 - 0.78 9.1 7.0 0.97 8.8 7.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_13 PF13166.4 015344.1_21022120_3 - 0.87 8.0 8.1 1.1 7.7 8.1 1.0 1 0 0 1 1 1 0 AAA domain Muted PF14942.4 015344.1_21022120_3 - 0.89 9.7 12.1 1.2 9.3 12.1 1.1 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein ACCA PF03255.12 015344.1_21022120_3 - 0.9 9.3 7.0 0.8 9.4 5.6 1.5 1 1 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit FUSC PF04632.10 015344.1_21022120_3 - 0.97 7.8 3.5 1.2 7.4 3.5 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family CENP-Q PF13094.4 015344.1_21022120_3 - 1.1 9.3 14.4 2.7 8.0 14.4 1.5 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF1043 PF06295.10 015344.1_21022120_3 - 1.1 9.1 9.0 1.6 8.6 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Uso1_p115_C PF04871.11 015344.1_21022120_3 - 1.5 9.1 15.6 5.2 7.3 15.5 1.8 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF883 PF05957.11 015344.1_21022120_3 - 1.5 9.3 7.0 0.9 10.0 4.9 1.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF4407 PF14362.4 015344.1_21022120_3 - 1.6 7.9 7.9 2.7 7.1 7.9 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Helo_like_N PF17111.3 015344.1_21022120_3 - 1.8 7.7 7.1 2.4 7.4 7.1 1.2 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins HemX PF04375.12 015344.1_21022120_3 - 2 7.5 9.2 2.5 7.2 9.2 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase G_path_suppress PF15991.3 015344.1_21022120_3 - 2.2 8.2 13.7 3.1 7.7 13.7 1.1 1 0 0 1 1 1 0 G-protein pathway suppressor XhlA PF10779.7 015344.1_21022120_3 - 2.2 8.4 7.5 0.82 9.8 3.2 2.1 1 1 1 2 2 2 0 Haemolysin XhlA IncA PF04156.12 015344.1_21022120_3 - 2.6 7.7 10.8 4.2 7.0 10.8 1.3 1 0 0 1 1 1 0 IncA protein PspB PF06667.10 015344.1_21022120_3 - 2.8 7.9 4.2 2.4 8.1 3.0 1.5 1 1 1 2 2 2 0 Phage shock protein B Fib_alpha PF08702.8 015344.1_21022120_3 - 3.6 7.6 8.5 6.2 6.9 7.5 1.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF812 PF05667.9 015344.1_21022120_3 - 4.3 6.0 15.5 5.3 5.7 15.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) HSP70 PF00012.18 015344.1_21022120_3 - 4.4 5.2 9.6 5.6 4.9 9.6 1.0 1 0 0 1 1 1 0 Hsp70 protein BST2 PF16716.3 015344.1_21022120_3 - 6 7.4 14.5 40 4.7 14.5 2.0 1 1 0 1 1 1 0 Bone marrow stromal antigen 2 SlyX PF04102.10 015344.1_21022120_3 - 6.3 7.4 9.6 1.3e+02 3.2 9.6 2.2 1 1 0 1 1 1 0 SlyX Spc7 PF08317.9 015344.1_21022120_3 - 6.6 5.4 13.7 7.8 5.1 13.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein OmpH PF03938.12 015344.1_21022120_3 - 9 6.1 14.9 12 5.8 14.9 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) 5_nucleotid PF05761.12 015344.1_21022120_3 - 9.9 4.8 7.3 13 4.4 7.3 1.0 1 0 0 1 1 1 0 5' nucleotidase family PNP_UDP_1 PF01048.18 036563.1_21023120_2 - 7.6e-48 162.7 0.0 8.9e-48 162.4 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Cupin_1 PF00190.20 036563.1_21023120_2 - 0.07 12.6 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Cupin DUF4938 PF16292.3 036563.1_21023120_2 - 0.1 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4938) bZIP_2 PF07716.13 003616.2_21023120_1 - 0.082 12.9 2.7 0.14 12.1 2.7 1.3 1 0 0 1 1 1 0 Basic region leucine zipper MHC_I PF00129.16 003616.2_21023120_2 - 1.2e-78 262.7 4.3 1.6e-78 262.2 4.3 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 003616.2_21023120_2 - 3.3e-16 59.4 2.6 3.6e-16 59.3 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin C1-set domain C2-set_2 PF08205.10 003616.2_21023120_2 - 3.1e-06 27.0 0.2 7.5e-06 25.8 0.2 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 003616.2_21023120_2 - 9.4e-06 26.0 1.0 0.027 14.9 0.0 2.7 1 1 1 2 2 2 2 Immunoglobulin domain ig PF00047.23 003616.2_21023120_2 - 0.0013 18.7 0.1 0.0034 17.4 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain MATalpha_HMGbox PF04769.10 003616.2_21023120_2 - 0.1 11.8 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box Pkinase_Tyr PF07714.15 001162365.1_32929001_1 - 3.3e-94 314.9 0.0 5.3e-94 314.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Focal_AT PF03623.11 001162365.1_32929001_1 - 1.7e-52 176.7 3.2 3.2e-52 175.9 3.2 1.5 1 0 0 1 1 1 1 Focal adhesion targeting region Pkinase PF00069.23 001162365.1_32929001_1 - 1e-43 149.5 0.0 1.8e-43 148.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain FERM_M PF00373.16 001162365.1_32929001_1 - 5.4e-12 46.0 1.4 1.7e-11 44.4 1.4 1.8 1 0 0 1 1 1 1 FERM central domain Kinase-like PF14531.4 001162365.1_32929001_1 - 0.026 13.7 0.0 0.064 12.4 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Copine PF07002.14 001360239.1_32929001_3 - 1.5e-90 302.3 0.0 1.9e-90 302.0 0.0 1.1 1 0 0 1 1 1 1 Copine C2 PF00168.28 001360239.1_32929001_3 - 4.8e-30 103.8 0.1 6.3e-14 52.0 0.0 2.3 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.7 001360239.1_32929001_3 - 3.2e-06 27.3 0.0 5.3e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus VCBS PF13517.4 001360239.1_32929001_3 - 0.093 13.2 0.2 0.21 12.1 0.2 1.6 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella UQ_con PF00179.24 001360327.1_32923001_2 - 1.9e-46 157.1 0.0 2.5e-46 156.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.4 001360327.1_32923001_2 - 0.0077 15.8 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.20 001360327.1_32923001_2 - 0.051 13.7 0.0 0.082 13.1 0.0 1.3 1 0 0 1 1 1 0 RWD domain ACT_3 PF10000.7 001360327.1_32923001_3 - 0.044 13.6 0.0 0.077 12.8 0.0 1.4 1 0 0 1 1 1 0 ACT domain Lbh PF15317.4 001360327.1_32923001_3 - 0.16 12.7 0.0 0.25 12.1 0.0 1.2 1 0 0 1 1 1 0 Cardiac transcription factor regulator, Developmental protein TPK_B1_binding PF04265.12 172624.3_32928001_1 - 0.074 12.6 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, vitamin B1 binding domain DPPIV_N PF00930.19 172624.3_32928001_3 - 1.6e-106 355.9 0.0 2.1e-106 355.5 0.0 1.1 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.19 172624.3_32928001_3 - 2.4e-55 187.2 0.0 3.8e-55 186.5 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.16 172624.3_32928001_3 - 5.8e-08 32.5 0.1 9.9e-08 31.8 0.1 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.18 172624.3_32928001_3 - 0.00039 20.0 0.0 0.00074 19.1 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.5 172624.3_32928001_3 - 0.00052 20.6 1.1 0.0019 18.8 0.0 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 172624.3_32928001_3 - 0.0076 15.8 0.4 0.09 12.3 0.1 2.6 3 0 0 3 3 3 1 alpha/beta hydrolase fold DLH PF01738.16 172624.3_32928001_3 - 0.013 14.9 0.0 0.042 13.3 0.0 1.8 1 1 0 1 1 1 0 Dienelactone hydrolase family Hydrolase_4 PF12146.6 172624.3_32928001_3 - 0.066 12.3 0.5 0.2 10.8 0.2 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.14 172624.3_32928001_3 - 0.11 12.2 0.1 14 5.3 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Qua1 PF16274.3 133235.3_32925001_2 - 3.4e-28 97.3 2.1 7.5e-28 96.2 2.1 1.6 1 0 0 1 1 1 1 Qua1 domain Sam68-YY PF16568.3 133235.3_32925001_2 - 3.3e-19 69.2 28.7 5.5e-19 68.5 28.7 1.4 1 0 0 1 1 1 1 Tyrosine-rich domain of Sam68 KH_1 PF00013.27 133235.3_32925001_2 - 6.3e-09 35.4 0.0 1.1e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 KH domain STAR_dimer PF16544.3 133235.3_32925001_2 - 0.027 13.9 0.0 0.06 12.8 0.0 1.5 1 0 0 1 1 1 0 Homodimerisation region of STAR domain protein zf-C4 PF00105.16 001100919.1_39525001_2 - 2.8e-29 101.2 18.1 5.5e-29 100.3 18.1 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001100919.1_39525001_2 - 1.7e-18 66.9 0.0 3.3e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001197206.1_32323001_2 - 1.8e-29 101.8 17.9 1.8e-29 101.8 17.9 1.7 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001197206.1_32323001_2 - 7.1e-20 71.3 0.0 1.9e-19 69.9 0.0 1.7 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor DUF3921 PF13060.4 001197206.1_32323001_2 - 0.086 12.8 0.0 1.9 8.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3921) zf-C4 PF00105.16 001283672.1_29525001_1 - 1.9e-29 101.8 18.1 4.4e-29 100.6 18.1 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001283672.1_29525001_1 - 1.1e-17 64.1 0.0 2.7e-17 62.9 0.0 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor 7tm_1 PF00001.19 001257120.1_21023001_1 - 1e-71 241.2 15.7 1.4e-71 240.8 15.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001257120.1_21023001_1 - 3.2e-15 56.1 17.8 4.3e-15 55.7 17.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001257120.1_21023001_1 - 2.6e-08 33.8 9.5 2.6e-08 33.8 9.5 2.1 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001257120.1_21023001_1 - 1.3e-06 27.8 15.0 1.3e-06 27.8 15.0 1.4 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx MAP17 PF15807.3 001257120.1_21023001_1 - 0.093 12.8 0.6 5.6 7.1 0.2 2.4 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF2208 PF09973.7 001257120.1_21023001_1 - 0.21 11.1 4.3 0.14 11.6 0.3 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) AAA PF00004.27 001256936.2_21025001_1 - 3.5e-38 130.9 0.0 6.7e-38 130.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.8 001256936.2_21025001_1 - 1.1e-08 34.7 0.0 2.8e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.10 001256936.2_21025001_1 - 8.3e-05 21.8 0.0 0.00016 20.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.12 001256936.2_21025001_1 - 0.00036 20.4 0.0 0.0016 18.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.12 001256936.2_21025001_1 - 0.00057 19.9 0.0 0.0014 18.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.4 001256936.2_21025001_1 - 0.00079 19.7 1.6 0.14 12.4 0.1 2.6 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 001256936.2_21025001_1 - 0.0019 18.3 1.1 0.085 13.0 0.2 2.7 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.11 001256936.2_21025001_1 - 0.013 14.3 0.1 0.032 13.0 0.1 1.5 1 1 0 1 1 1 0 TIP49 C-terminus NIF3 PF01784.16 001256936.2_21025001_1 - 0.023 14.2 0.0 0.042 13.3 0.0 1.4 1 0 0 1 1 1 0 NIF3 (NGG1p interacting factor 3) Mg_chelatase PF01078.19 001256936.2_21025001_1 - 0.1 11.8 0.2 0.23 10.7 0.2 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.15 001256936.2_21025001_1 - 0.13 11.8 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein 6PF2K PF01591.16 153430.1_32927120_1 - 7.2e-82 273.9 0.0 1.1e-81 273.3 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.4 153430.1_32927120_1 - 4.3e-06 26.8 0.0 7.4e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain Prefoldin PF02996.15 153430.1_32927120_1 - 0.0047 16.7 0.0 0.0079 16.0 0.0 1.2 1 0 0 1 1 1 1 Prefoldin subunit KTI12 PF08433.8 153430.1_32927120_1 - 0.03 13.6 0.0 0.045 13.0 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 His_Phos_1 PF00300.20 153430.1_32927120_3 - 8e-41 139.7 0.0 1.1e-40 139.3 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) 6PF2K PF01591.16 153430.1_32927120_3 - 2.9e-12 46.3 0.3 4.5e-12 45.6 0.3 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_2 PF00328.20 153430.1_32927120_3 - 0.079 12.2 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) WD40 PF00400.30 001280545.1_26229001_3 - 9.7e-08 32.4 12.1 0.86 10.5 0.1 6.9 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001280545.1_26229001_3 - 2.9e-07 30.6 0.1 0.15 12.2 0.0 4.2 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.12 001280545.1_26229001_3 - 7.1e-05 21.9 6.3 0.054 12.4 0.0 4.9 5 1 0 5 5 5 2 Coatomer WD associated region TPR_7 PF13176.4 001280545.1_26229001_3 - 0.0012 18.6 5.2 0.043 13.7 0.1 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat Clathrin PF00637.18 001280545.1_26229001_3 - 0.0046 16.7 0.7 0.52 10.0 0.1 3.4 1 1 2 3 3 3 1 Region in Clathrin and VPS PHTB1_N PF14727.4 001280545.1_26229001_3 - 0.011 15.0 0.1 0.02 14.1 0.1 1.3 1 0 0 1 1 1 0 PTHB1 N-terminus TPR_12 PF13424.4 001280545.1_26229001_3 - 0.028 14.6 1.4 6.5 7.0 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat CENP-B_dimeris PF09026.8 001280545.1_26229001_3 - 0.18 12.0 1.6 0.38 11.0 1.6 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Vps39_1 PF10366.7 001280545.1_26229001_3 - 0.24 11.6 1.8 47 4.2 0.1 3.9 4 1 1 5 5 5 0 Vacuolar sorting protein 39 domain 1 TPR_14 PF13428.4 001280545.1_26229001_3 - 0.32 11.8 1.7 1.2e+02 3.8 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_2 PF07719.15 001280545.1_26229001_3 - 1.5 9.0 15.2 8.6 6.6 0.1 5.0 5 0 0 5 5 4 0 Tetratricopeptide repeat APS_kinase PF01583.18 001201470.1_32928001_3 - 1.8e-71 239.0 0.0 2.7e-71 238.4 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase ATP-sulfurylase PF01747.15 001201470.1_32928001_3 - 1.4e-67 227.2 0.0 2.2e-67 226.5 0.0 1.3 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.4 001201470.1_32928001_3 - 1.8e-50 170.6 0.0 2.7e-50 170.0 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.4 001201470.1_32928001_3 - 6e-05 23.1 0.0 0.00012 22.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 001201470.1_32928001_3 - 0.0028 18.0 0.0 0.0064 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain K_channel_TID PF07941.9 182569.3_26227001_1 - 0.59 10.5 3.6 1.1 9.6 3.6 1.3 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain GDPD PF03009.15 182569.3_26227001_3 - 6.4e-31 107.9 0.0 1.7e-24 86.8 0.0 2.1 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.4 182569.3_26227001_3 - 0.00077 19.8 0.1 0.0015 18.9 0.1 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Guanylate_kin PF00625.19 001351275.1_26229001_2 - 8.9e-65 217.6 0.1 1.3e-64 217.1 0.1 1.3 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 001351275.1_26229001_2 - 4.4e-64 212.7 8.3 5.2e-21 74.7 0.1 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) MAGUK_N_PEST PF10608.7 001351275.1_26229001_2 - 5e-31 107.5 5.3 2e-28 99.1 5.3 2.4 1 1 0 1 1 1 1 Polyubiquitination (PEST) N-terminal domain of MAGUK L27_1 PF09058.8 001351275.1_26229001_2 - 4.1e-26 90.7 0.7 9.1e-26 89.6 0.7 1.6 1 0 0 1 1 1 1 L27_1 PDZ_assoc PF10600.7 001351275.1_26229001_2 - 1.2e-22 80.4 7.9 1.2e-22 80.4 7.9 2.4 2 0 0 2 2 2 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.4 001351275.1_26229001_2 - 2.8e-15 56.3 1.9 0.00049 20.2 0.0 3.4 3 0 0 3 3 3 3 PDZ domain SH3_2 PF07653.15 001351275.1_26229001_2 - 2.6e-08 33.3 0.0 5.7e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001351275.1_26229001_2 - 1.1e-07 31.2 0.0 2e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001351275.1_26229001_2 - 0.012 15.3 0.0 0.028 14.1 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain Endonuclease_NS PF01223.21 153325.1_26227120_1 - 2.1e-49 168.3 0.0 3e-49 167.8 0.0 1.2 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease RE_HindIII PF09518.8 153325.1_26227120_1 - 0.048 12.8 0.0 7.1 5.6 0.0 2.1 2 0 0 2 2 2 0 HindIII restriction endonuclease PsbX PF06596.9 153325.1_26227120_1 - 0.91 9.4 2.6 2.5 8.1 2.6 1.7 1 0 0 1 1 1 0 Photosystem II reaction centre X protein (PsbX) Endonuclease_NS PF01223.21 153324.1_26227120_2 - 2.1e-49 168.2 0.0 3e-49 167.8 0.0 1.2 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease RE_HindIII PF09518.8 153324.1_26227120_2 - 0.046 12.8 0.0 6.9 5.7 0.0 2.1 2 0 0 2 2 2 0 HindIII restriction endonuclease 7tm_1 PF00001.19 073042.1_45726120_1 - 1.1e-46 159.1 0.0 1.5e-46 158.7 0.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4106 PF13388.4 073042.1_45726120_1 - 7.1 5.6 4.8 11 5.0 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) 7tm_1 PF00001.19 073042.1_45726120_2 - 3.2e-06 26.5 0.4 3.2e-06 26.5 0.4 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Fringe PF02434.14 001040168.1_26223001_3 - 9.5e-122 405.1 0.0 1.1e-121 404.9 0.0 1.0 1 0 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.19 001040168.1_26223001_3 - 0.029 14.1 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 Galactosyltransferase Fur_reg_FbpA PF13076.4 001040168.1_26223001_3 - 0.079 12.5 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Fur-regulated basic protein A Prion PF00377.16 001009481.1_39529001_2 - 3.2e-36 123.6 2.5 4.8e-36 123.0 2.5 1.3 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain Prion_bPrPp PF11587.6 001009481.1_39529001_2 - 3.3e-18 65.1 1.5 6.8e-18 64.1 1.5 1.6 1 0 0 1 1 1 1 Major prion protein bPrPp - N terminal Metallophos PF00149.26 001081988.1_37923001_3 - 2e-23 83.9 0.2 2.6e-23 83.5 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.5 001081988.1_37923001_3 - 0.0015 18.7 0.0 0.0091 16.1 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Toxin_1 PF00087.19 001012435.1_39721001_1 - 1.9e-06 27.8 16.1 2.4e-06 27.6 16.1 1.1 1 0 0 1 1 1 1 Snake toxin UPAR_LY6_2 PF16975.3 001012435.1_39721001_1 - 0.001 19.1 7.1 0.0013 18.7 7.1 1.2 1 0 0 1 1 1 1 Ly6/PLAUR domain-containing protein 6, Lypd6 UPAR_LY6 PF00021.19 001012435.1_39721001_1 - 0.0039 17.7 14.3 0.005 17.4 14.3 1.1 1 0 0 1 1 1 1 u-PAR/Ly-6 domain zf-C2H2 PF00096.24 001012051.1_45728001_1 - 7.9e-11 41.7 4.4 0.00017 21.7 0.7 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001012051.1_45728001_1 - 8.1e-11 41.7 12.9 4.4e-06 26.8 0.2 3.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001012051.1_45728001_1 - 5.4e-07 29.8 3.7 0.0023 18.5 0.4 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001012051.1_45728001_1 - 8.4e-07 28.7 0.8 3.3e-06 26.8 0.2 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.5 001012051.1_45728001_1 - 0.00055 20.1 0.3 0.00055 20.1 0.3 2.3 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001012051.1_45728001_1 - 0.0018 18.4 0.6 0.0068 16.6 0.1 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding BAR_3 PF16746.3 001107848.1_45728001_1 - 1.8e-76 256.9 19.5 2.7e-76 256.3 19.5 1.3 1 0 0 1 1 1 1 BAR domain of APPL family RhoGAP PF00620.25 001107848.1_45728001_1 - 7.5e-42 142.6 0.0 1.9e-41 141.3 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.27 001107848.1_45728001_1 - 2.9e-08 34.0 0.0 7.9e-08 32.6 0.0 1.8 1 0 0 1 1 1 1 PH domain Arfaptin PF06456.11 001107848.1_45728001_1 - 0.015 14.7 4.3 0.038 13.4 4.3 1.6 1 0 0 1 1 1 0 Arfaptin-like domain Patched PF02460.16 001107848.1_45728001_1 - 1.2 7.0 5.2 1.2 7.0 3.1 1.8 1 1 1 2 2 2 0 Patched family V_ATPase_I PF01496.17 130840.2_26227001_1 - 0 1101.0 8.3 0 1100.8 8.3 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Bacillus_HBL PF05791.9 130840.2_26227001_1 - 0.056 13.0 1.0 0.14 11.7 1.0 1.6 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) ArgK PF03308.14 001106174.1_45727001_1 - 2.6e-93 311.7 0.1 3.4e-93 311.4 0.1 1.1 1 0 0 1 1 1 1 ArgK protein cobW PF02492.17 001106174.1_45727001_1 - 0.00014 21.3 0.0 0.00032 20.2 0.0 1.5 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.15 001106174.1_45727001_1 - 0.013 15.1 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.4 001106174.1_45727001_1 - 0.027 14.6 0.1 0.11 12.7 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.4 001106174.1_45727001_1 - 0.053 13.1 0.0 0.094 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.25 001106174.1_45727001_1 - 0.096 13.1 0.1 0.3 11.5 0.1 1.7 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.4 001106174.1_45727001_1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.21 001106174.1_45727001_1 - 0.15 12.0 0.0 6 6.9 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase Thymidylate_kin PF02223.15 001106174.1_45727001_1 - 0.2 11.2 0.0 0.34 10.4 0.0 1.3 1 0 0 1 1 1 0 Thymidylate kinase AAA_23 PF13476.4 001106174.1_45727001_1 - 0.24 11.8 0.0 0.41 11.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain Lipocalin PF00061.21 001082497.2_21022001_2 - 4.7e-30 104.6 0.2 5.8e-30 104.2 0.2 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.10 001082497.2_21022001_2 - 0.082 12.8 0.0 5.3 6.9 0.0 2.3 2 1 0 2 2 2 0 Lipocalin-like domain bZIP_1 PF00170.19 031018.1_45724001_3 - 1e-12 47.9 6.5 1.6e-12 47.2 6.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 031018.1_45724001_3 - 7.1e-09 35.5 6.8 1.5e-08 34.5 6.8 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 031018.1_45724001_3 - 0.0066 16.8 6.9 0.013 15.9 6.5 1.6 1 1 0 1 1 1 1 bZIP Maf transcription factor zf-C2H2 PF00096.24 031018.1_45724001_3 - 0.032 14.6 1.5 0.064 13.6 1.5 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type C1_1 PF00130.20 001107446.1_45729001_1 - 1.1e-07 31.5 13.1 2.4e-07 30.4 13.1 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PDZ PF00595.22 001107446.1_45729001_1 - 1.1e-07 32.0 0.1 1.9e-07 31.2 0.1 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001107446.1_45729001_1 - 1.9e-07 31.2 0.1 3.8e-07 30.2 0.1 1.4 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.12 001107446.1_45729001_1 - 0.048 13.8 0.0 0.087 13.0 0.0 1.3 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain UQ_con PF00179.24 013050.1_45723001_1 - 1.7e-48 163.7 0.0 2.2e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.4 013050.1_45723001_1 - 0.00021 20.8 0.0 0.00034 20.2 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B Arrestin_N PF00339.27 214079.1_49823001_3 - 2.8e-36 124.7 0.1 3.5e-33 114.6 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 214079.1_49823001_3 - 1.8e-22 80.0 1.6 2.7e-22 79.5 1.6 1.2 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Transglut_C PF00927.20 214079.1_49823001_3 - 0.016 15.2 0.6 0.036 14.1 0.6 1.5 1 0 0 1 1 1 0 Transglutaminase family, C-terminal ig like domain BatD PF13584.4 214079.1_49823001_3 - 0.021 13.6 0.1 0.031 13.1 0.1 1.2 1 0 0 1 1 1 0 Oxygen tolerance DUF2079 PF09852.7 214079.1_49823001_3 - 0.033 12.9 0.1 0.056 12.2 0.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) IMD PF08397.9 001130563.1_45729001_1 - 4.4e-104 346.5 4.4 5.7e-104 346.1 4.4 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain WH2 PF02205.18 001130563.1_45729001_1 - 1e-06 28.2 0.1 2.2e-06 27.1 0.1 1.6 1 0 0 1 1 1 1 WH2 motif Bmt2 PF11968.6 001109221.2_45723001_1 - 1.7e-07 31.2 0.3 0.00017 21.4 0.3 2.2 1 1 1 2 2 2 2 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 RdRP_1 PF00680.18 001109221.2_45723001_1 - 0.034 12.5 0.1 0.049 12.0 0.1 1.2 1 0 0 1 1 1 0 RNA dependent RNA polymerase COX8 PF02285.13 007751.3_32921001_3 - 1.7e-21 75.7 0.3 2.5e-21 75.1 0.3 1.3 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIII Serum_albumin PF00273.18 001082344.1_37924001_2 - 2.9e-160 528.6 39.1 6.6e-59 198.5 7.3 3.0 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.8 001082344.1_37924001_2 - 4e-06 26.6 16.1 0.071 13.0 0.2 5.7 5 0 0 5 5 5 3 Vitamin D binding protein, domain III ANF_receptor PF01094.26 001111114.1_45727001_3 - 1.5e-76 257.7 0.0 2.2e-76 257.1 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 001111114.1_45727001_3 - 1.3e-53 180.7 0.1 2.1e-53 180.0 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 001111114.1_45727001_3 - 2.1e-46 156.7 0.0 7.1e-46 155.0 0.0 1.9 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001111114.1_45727001_3 - 2.3e-18 66.3 0.0 4.2e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.4 001111114.1_45727001_3 - 2e-09 37.5 0.0 3.3e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein Hydrolase_4 PF12146.6 001014028.1_45724001_3 - 3.4e-12 46.0 0.0 1.8e-06 27.2 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.19 001014028.1_45724001_3 - 4.3e-07 29.5 0.0 3.9e-05 23.1 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.18 001014028.1_45724001_3 - 3.5e-06 26.7 0.1 0.017 14.6 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001014028.1_45724001_3 - 3.5e-06 27.7 0.0 0.00049 20.7 0.0 2.3 1 1 1 2 2 2 1 Alpha/beta hydrolase family DLH PF01738.16 001014028.1_45724001_3 - 0.0033 16.9 0.0 0.0054 16.2 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.11 001014028.1_45724001_3 - 0.009 15.6 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) UPF0227 PF05728.10 001014028.1_45724001_3 - 0.01 15.7 0.0 0.13 12.1 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) DUF818 PF05677.10 001014028.1_45724001_3 - 0.012 14.4 0.1 0.018 13.9 0.1 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Abhydrolase_5 PF12695.5 001014028.1_45724001_3 - 0.1 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family HMG_box_2 PF09011.8 001004034.1_49825001_3 - 1.3e-41 140.9 13.7 2.3e-26 92.1 8.3 2.5 2 0 0 2 2 2 2 HMG-box domain HMG_box PF00505.17 001004034.1_49825001_3 - 1.7e-39 134.0 13.0 5.1e-26 90.7 0.6 2.6 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_5 PF14887.4 001004034.1_49825001_3 - 0.023 14.5 12.6 0.49 10.3 1.9 2.3 2 0 0 2 2 2 0 HMG (high mobility group) box 5 Nucleo_P87 PF07267.9 001004034.1_49825001_3 - 0.46 9.2 8.8 0.53 8.9 8.8 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 ANAPC15 PF15243.4 001004034.1_49825001_3 - 2.8 8.3 20.7 5.2 7.4 20.7 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 NOA36 PF06524.10 001004034.1_49825001_3 - 4 6.6 22.4 6.9 5.8 22.4 1.3 1 0 0 1 1 1 0 NOA36 protein Pox_Ag35 PF03286.12 001004034.1_49825001_3 - 4.8 6.8 19.0 11 5.6 19.0 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Astro_capsid_p PF12226.6 001004034.1_49825001_3 - 5.3 5.9 17.2 7.4 5.5 17.2 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Nop14 PF04147.10 001004034.1_49825001_3 - 6.7 4.7 25.5 8.9 4.3 25.5 1.1 1 0 0 1 1 1 0 Nop14-like family Piwi PF02171.15 001107276.1_45729001_1 - 4.5e-86 288.7 0.1 6.3e-86 288.2 0.1 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.20 001107276.1_45729001_1 - 2.9e-32 111.2 0.4 4.9e-32 110.5 0.4 1.3 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.8 001107276.1_45729001_1 - 1e-08 34.6 0.0 2.5e-08 33.3 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoN PF16486.3 001107276.1_45729001_1 - 0.002 18.7 0.0 0.0039 17.8 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of argonaute Kv2channel PF03521.12 001082137.1_37927001_1 - 5.3e-151 501.8 15.1 8.2e-151 501.1 15.1 1.3 1 0 0 1 1 1 1 Kv2 voltage-gated K+ channel Ion_trans PF00520.29 001082137.1_37927001_1 - 3.1e-50 170.6 7.1 4e-50 170.2 7.1 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001082137.1_37927001_1 - 1e-31 109.0 0.0 2.7e-31 107.7 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 001082137.1_37927001_1 - 1.2e-11 44.2 4.5 1.2e-11 44.2 4.5 1.9 2 0 0 2 2 2 1 Ion channel adh_short PF00106.23 031682.1_45722001_1 - 1.3e-46 158.4 1.9 1.6e-46 158.1 1.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 031682.1_45722001_1 - 5.6e-42 143.8 0.1 6.9e-42 143.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 031682.1_45722001_1 - 5e-11 42.7 1.3 9.6e-11 41.8 1.3 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.19 031682.1_45722001_1 - 0.036 13.4 0.3 0.061 12.6 0.3 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family CBFD_NFYB_HMF PF00808.21 031553.2_45726001_1 - 3.3e-28 97.6 0.6 5.5e-28 96.9 0.6 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.22 031553.2_45726001_1 - 0.00012 22.4 0.0 0.00022 21.5 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.14 031553.2_45726001_1 - 0.0094 15.8 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit CENP-T_C PF15511.4 031553.2_45726001_1 - 0.019 15.0 0.0 0.032 14.2 0.0 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Ras PF00071.20 001032989.1_32322001_2 - 1.5e-57 193.6 0.1 1.7e-57 193.4 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001032989.1_32322001_2 - 7.9e-21 74.4 0.0 1.3e-20 73.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001032989.1_32322001_2 - 7.1e-09 35.2 0.0 9.2e-09 34.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001032989.1_32322001_2 - 2.6e-06 27.0 0.1 1.7e-05 24.3 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001032989.1_32322001_2 - 6.8e-06 25.9 0.0 0.033 13.9 0.0 2.3 2 1 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 001032989.1_32322001_2 - 0.00015 21.7 0.0 0.00024 21.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001032989.1_32322001_2 - 0.0026 17.2 0.0 0.018 14.5 0.0 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.16 001032989.1_32322001_2 - 0.078 12.1 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Septin G-alpha PF00503.18 001032989.1_32322001_2 - 0.12 11.3 0.0 5 6.1 0.0 2.0 1 1 1 2 2 2 0 G-protein alpha subunit Ldh_1_N PF00056.21 001032989.1_32322001_2 - 0.13 12.2 0.0 0.62 10.0 0.0 1.9 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain ParA PF10609.7 001032989.1_32322001_2 - 0.17 11.1 0.1 0.55 9.5 0.0 1.7 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase Ion_trans PF00520.29 001082191.1_37929001_1 - 7.5e-250 824.3 80.4 8.4e-68 228.1 1.1 4.1 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.3 001082191.1_37929001_1 - 2.1e-37 126.6 0.0 7.5e-37 124.8 0.0 2.0 2 0 0 2 2 2 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 001082191.1_37929001_1 - 1.7e-31 108.2 0.0 4e-31 107.0 0.0 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 001082191.1_37929001_1 - 6.6e-09 34.8 27.4 1.5e-06 27.1 9.5 9.3 6 4 3 10 10 10 5 Polycystin cation channel Hist_deacetyl PF00850.17 005474.4_26229001_3 - 3e-79 266.6 0.0 3e-79 266.6 0.0 2.0 2 0 0 2 2 2 1 Histone deacetylase domain HDAC4_Gln PF12203.6 005474.4_26229001_3 - 1.9e-27 95.2 55.8 1.9e-27 95.2 55.8 3.5 2 1 0 2 2 2 1 Glutamine rich N terminal domain of histone deacetylase 4 zf-TFIIB PF13453.4 005474.4_26229001_3 - 1 8.6 4.2 2.4 7.4 4.2 1.6 1 0 0 1 1 1 0 Transcription factor zinc-finger TFIIA PF03153.11 005474.4_26229001_3 - 4.1 7.2 44.9 0.51 10.1 15.6 2.6 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit WD40 PF00400.30 012453.2_26227001_3 - 6.9e-25 86.7 5.6 4.9e-08 33.4 0.1 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 012453.2_26227001_3 - 3.3e-08 33.6 0.1 1 9.6 0.0 4.4 4 0 0 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 012453.2_26227001_3 - 0.0068 15.3 0.1 5.1 5.8 0.0 3.1 3 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.9 012453.2_26227001_3 - 0.098 12.4 0.1 1.9 8.2 0.0 2.5 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Vasculin PF15337.4 001133511.1_43527001_2 - 3.5e-41 139.8 3.6 3.5e-41 139.8 3.6 2.5 2 0 0 2 2 2 1 Vascular protein family Vasculin-like 1 Actin PF00022.17 031068.1_45725001_2 - 1.1e-89 300.8 0.0 2.4e-56 191.0 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.11 031068.1_45725001_2 - 0.00033 19.4 0.0 0.26 9.9 0.0 2.4 2 1 0 2 2 2 2 MreB/Mbl protein Robl_LC7 PF03259.15 031068.1_45725001_2 - 0.15 11.7 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 Roadblock/LC7 domain Lipocalin PF00061.21 001081868.1_21022001_2 - 3.6e-32 111.4 0.0 4.3e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Triabin PF03973.11 001081868.1_21022001_2 - 0.0056 16.4 0.1 0.022 14.5 0.0 1.8 1 1 1 2 2 2 1 Triabin VWD PF00094.23 001113286.1_49829001_2 - 1.6e-71 239.6 26.3 1.5e-28 99.9 1.7 3.9 4 0 0 4 4 4 3 von Willebrand factor type D domain C8 PF08742.9 001113286.1_49829001_2 - 7.3e-32 109.5 48.0 1.8e-15 57.0 6.4 4.2 4 0 0 4 4 4 3 C8 domain TIL PF01826.15 001113286.1_49829001_2 - 4.8e-09 36.2 44.5 2e-07 31.0 9.3 10.5 11 1 1 12 12 12 4 Trypsin Inhibitor like cysteine rich domain Cathelicidins PF00666.15 001082325.2_37922001_2 - 1.4e-39 134.4 0.1 1.9e-39 133.9 0.1 1.2 1 0 0 1 1 1 1 Cathelicidin Spp-24 PF07448.9 001082325.2_37922001_2 - 0.003 17.6 0.3 0.013 15.6 0.3 2.0 2 1 0 2 2 2 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Presenilin PF01080.15 019163.3_45723001_1 - 2.7e-166 553.1 6.9 2.7e-166 553.1 6.9 2.0 2 0 0 2 2 2 1 Presenilin VIT1 PF01988.17 019163.3_45723001_1 - 0.11 12.2 3.3 6.7 6.4 0.0 2.7 2 1 0 2 2 2 0 VIT family LRRC37AB_C PF14914.4 019163.3_45723001_1 - 0.14 11.9 3.9 2.5 7.8 0.1 2.5 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain Defensin_propep PF00879.16 001012639.1_39721001_1 - 6.4e-25 87.1 1.9 8.7e-25 86.7 1.9 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001012639.1_39721001_1 - 5.8e-10 39.4 13.1 8.4e-10 38.9 13.1 1.3 1 0 0 1 1 1 1 Mammalian defensin AT_hook PF02178.17 139327.1_45721001_1 - 0.0013 18.2 34.2 0.17 11.7 6.9 3.6 3 0 0 3 3 3 3 AT hook motif Raftlin PF15250.4 001133554.1_43526001_3 - 1.9e-188 626.9 0.0 2.4e-188 626.5 0.0 1.1 1 0 0 1 1 1 1 Raftlin Forkhead PF00250.16 053832.1_45725001_3 - 1.4e-35 121.3 0.1 2.1e-35 120.8 0.1 1.2 1 0 0 1 1 1 1 Forkhead domain CBF PF03914.15 153570.2_32925001_2 - 2.9e-41 141.1 0.9 6.8e-41 139.9 0.9 1.6 1 0 0 1 1 1 1 CBF/Mak21 family Ribosomal_L24e PF01246.18 001128841.1_22422001_1 - 6.4e-34 115.8 0.7 6.4e-34 115.8 0.7 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e Lipocalin PF00061.21 001101695.1_37922001_3 - 1.2e-17 64.3 0.2 1.5e-17 64.0 0.2 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family ApoM PF11032.6 001101695.1_37922001_3 - 3.8e-05 23.3 0.1 4.7e-05 23.0 0.1 1.1 1 0 0 1 1 1 1 ApoM domain DPPIV_N PF00930.19 001009838.1_22426001_1 - 1.4e-108 362.7 7.6 1.8e-108 362.3 7.6 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.19 001009838.1_22426001_1 - 3.2e-58 196.5 2.5 6.3e-58 195.6 2.5 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.16 001009838.1_22426001_1 - 1.7e-05 24.4 0.0 4.5e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 Dienelactone hydrolase family LIP PF03583.12 001009838.1_22426001_1 - 6.4e-05 22.3 0.3 0.00018 20.8 0.1 1.7 2 0 0 2 2 2 1 Secretory lipase Abhydrolase_6 PF12697.5 001009838.1_22426001_1 - 0.0018 18.8 0.0 0.0053 17.3 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.10 001009838.1_22426001_1 - 0.028 13.0 0.0 0.14 10.7 0.0 2.0 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) PD40 PF07676.10 001009838.1_22426001_1 - 0.078 12.8 0.6 50 3.9 0.0 4.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Abhydrolase_2 PF02230.14 001009838.1_22426001_1 - 0.25 11.0 2.2 2 8.1 0.3 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Peptidase_S15 PF02129.16 001009838.1_22426001_1 - 0.74 9.2 10.4 0.81 9.1 0.6 3.2 2 1 1 3 3 3 0 X-Pro dipeptidyl-peptidase (S15 family) AAA_29 PF13555.4 001009838.1_22426001_2 - 0.025 14.2 0.1 0.055 13.1 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Podoplanin PF05808.9 019358.1_45724001_3 - 3.5e-56 189.6 1.6 4.8e-56 189.2 1.6 1.2 1 0 0 1 1 1 1 Podoplanin TMEM154 PF15102.4 019358.1_45724001_3 - 0.038 13.8 0.0 0.065 13.0 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family Glycophorin_A PF01102.16 019358.1_45724001_3 - 0.079 13.1 0.1 0.14 12.3 0.1 1.3 1 0 0 1 1 1 0 Glycophorin A Endomucin PF07010.10 019358.1_45724001_3 - 0.086 12.7 3.5 0.13 12.1 3.5 1.2 1 0 0 1 1 1 0 Endomucin COesterase PF00135.26 001009364.1_22424001_2 - 7.1e-178 592.6 0.0 8.2e-178 592.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family AChE_tetra PF08674.8 001009364.1_22424001_2 - 3.4e-22 77.7 8.3 9.2e-22 76.3 8.3 1.8 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain Abhydrolase_3 PF07859.11 001009364.1_22424001_2 - 1.5e-06 28.0 0.0 3.1e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ribosom_S12_S23 PF00164.23 213764.1_49821001_2 - 9.8e-64 212.9 1.9 1.1e-63 212.7 1.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 VGCC_alpha2 PF08473.9 001082276.1_37928001_3 - 6.8e-215 713.7 1.1 1.5e-214 712.6 1.2 1.6 2 0 0 2 2 2 1 Neuronal voltage-dependent calcium channel alpha 2acd VWA_N PF08399.9 001082276.1_37928001_3 - 2.2e-40 137.8 0.3 6.1e-40 136.4 0.2 1.8 2 0 0 2 2 2 1 VWA N-terminal VWA PF00092.26 001082276.1_37928001_3 - 3.9e-21 76.0 0.8 7.2e-21 75.1 0.8 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 001082276.1_37928001_3 - 1.9e-15 57.0 0.0 3.4e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_1 PF02743.16 001082276.1_37928001_3 - 5.5e-11 42.6 11.2 6e-09 35.9 0.1 4.1 4 1 0 4 4 4 2 Cache domain VWA_2 PF13519.4 001082276.1_37928001_3 - 7.6e-11 42.5 1.1 4.5e-10 40.0 0.4 2.3 2 0 0 2 2 2 1 von Willebrand factor type A domain IFN-gamma PF00714.15 001082276.1_37928001_3 - 0.07 12.8 0.5 0.17 11.6 0.5 1.6 1 0 0 1 1 1 0 Interferon gamma NIPSNAP PF07978.11 001017486.1_45723001_3 - 3.8e-37 126.5 1.5 2.9e-31 107.6 0.5 2.3 2 0 0 2 2 2 2 NIPSNAP PMP22_Claudin PF00822.18 080691.1_45722001_1 - 1.4e-50 171.3 1.1 2e-50 170.8 0.8 1.3 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 080691.1_45722001_1 - 1.5e-20 73.7 0.4 2.7e-20 72.8 0.4 1.4 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction ABC2_membrane_2 PF12679.5 080691.1_45722001_1 - 0.08 12.1 1.6 0.13 11.4 1.6 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein NfeD PF01957.16 080691.1_45722001_1 - 1.3 9.3 3.7 0.43 10.8 0.3 1.9 2 1 0 2 2 2 0 NfeD-like C-terminal, partner-binding MRG PF05712.11 001098562.1_39724001_3 - 1.1e-52 178.1 0.4 1.6e-52 177.6 0.4 1.2 1 0 0 1 1 1 1 MRG LRR_8 PF13855.4 001009223.1_22427001_1 - 1.1e-45 153.0 54.7 6.9e-11 41.6 0.5 10.4 3 2 7 11 11 11 11 Leucine rich repeat LRR_4 PF12799.5 001009223.1_22427001_1 - 1.4e-33 114.1 49.0 1.4e-06 28.3 3.9 10.4 6 3 1 10 10 10 8 Leucine Rich repeats (2 copies) TIR PF01582.18 001009223.1_22427001_1 - 4.1e-32 111.3 0.1 7.7e-32 110.4 0.1 1.4 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.31 001009223.1_22427001_1 - 5e-12 44.4 56.2 0.59 10.7 0.8 16.6 16 1 0 16 16 16 4 Leucine Rich Repeat LRR_9 PF14580.4 001009223.1_22427001_1 - 1.3e-09 37.7 15.4 0.0053 16.1 0.1 4.8 2 2 4 6 6 6 5 Leucine-rich repeat TIR_2 PF13676.4 001009223.1_22427001_1 - 1.2e-08 35.1 0.1 2.2e-08 34.2 0.1 1.4 1 0 0 1 1 1 1 TIR domain LRR_6 PF13516.4 001009223.1_22427001_1 - 0.00042 20.0 56.9 0.6 10.2 0.2 13.8 15 0 0 15 15 15 4 Leucine Rich repeat DUF1863 PF08937.9 001009223.1_22427001_1 - 0.0012 19.0 0.2 0.0049 17.0 0.2 1.9 1 1 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) Curto_V2 PF07325.9 001009223.1_22427001_1 - 0.059 13.1 0.2 0.14 11.9 0.2 1.5 1 0 0 1 1 1 0 Curtovirus V2 protein PMSI1 PF15322.4 001007638.1_45723001_2 - 7.8e-137 455.7 11.4 9.7e-137 455.4 11.4 1.0 1 0 0 1 1 1 1 Protein missing in infertile sperm 1, putative Pkinase_Tyr PF07714.15 010208.4_32927001_1 - 1.7e-89 299.4 0.0 2.6e-89 298.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 010208.4_32927001_1 - 1.3e-40 139.3 0.0 1.8e-40 138.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 010208.4_32927001_1 - 4.6e-28 97.0 0.2 9.8e-28 95.9 0.2 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 010208.4_32927001_1 - 5.5e-18 64.2 0.1 1.8e-17 62.5 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 010208.4_32927001_1 - 3.8e-11 42.5 0.1 8.7e-11 41.4 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 010208.4_32927001_1 - 3.3e-10 39.4 0.0 7.1e-10 38.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 010208.4_32927001_1 - 0.12 12.5 0.1 0.3 11.2 0.1 1.7 1 0 0 1 1 1 0 Bacterial SH3 domain TFIID_30kDa PF03540.11 001134735.1_45722001_1 - 1.6e-26 91.9 0.0 2.4e-26 91.3 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Bromo_TP PF07524.11 001134735.1_45722001_1 - 0.0032 17.3 0.0 0.041 13.8 0.0 2.1 1 1 0 1 1 1 1 Bromodomain associated Presenilin PF01080.15 001134735.1_45722001_1 - 0.69 8.5 2.6 0.77 8.3 2.6 1.1 1 0 0 1 1 1 0 Presenilin EOS1 PF12326.6 001134735.1_45722001_2 - 0.12 12.1 0.3 0.095 12.5 0.3 1.1 1 0 0 1 1 1 0 N-glycosylation protein Afi1 PF07792.10 001134735.1_45722001_2 - 0.26 11.7 5.5 0.34 11.3 5.5 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking EOS1 PF12326.6 001134735.1_45722001_3 - 0.044 13.6 0.5 0.048 13.5 0.5 1.1 1 0 0 1 1 1 0 N-glycosylation protein Presenilin PF01080.15 001134735.1_45722001_3 - 0.61 8.6 1.8 0.68 8.5 1.8 1.1 1 0 0 1 1 1 0 Presenilin Connexin PF00029.17 001134735.1_45722001_3 - 0.79 9.3 10.7 1.1 8.8 10.7 1.2 1 0 0 1 1 1 0 Connexin Eapp_C PF10238.7 001134735.1_45722001_3 - 1.9 8.4 12.5 3 7.8 12.5 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein Pex24p PF06398.9 001134735.1_45722001_3 - 2.5 6.9 7.1 3 6.6 7.1 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin SR-25 PF10500.7 001134735.1_45722001_3 - 2.7 7.4 40.2 5 6.5 40.2 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein 7tm_1 PF00001.19 001134735.1_45722001_3 - 5.4 6.0 8.2 6.6 5.7 8.2 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.19 001009242.1_22423001_1 - 1.1e-48 165.7 13.1 1.4e-48 165.3 13.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Rhodopsin_N PF10413.7 001009242.1_22423001_1 - 5.1e-24 83.7 3.7 5.1e-24 83.7 3.7 2.2 2 0 0 2 2 2 1 Amino terminal of the G-protein receptor rhodopsin 7TM_GPCR_Srv PF10323.7 001009242.1_22423001_1 - 1.9e-11 43.7 18.4 3.3e-11 42.9 18.4 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.7 001009242.1_22423001_1 - 2.5e-11 43.3 17.3 2.1e-10 40.3 17.3 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.7 001009242.1_22423001_1 - 2e-09 37.1 16.1 2.7e-09 36.7 16.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001009242.1_22423001_1 - 2.8e-05 23.9 15.7 0.00017 21.3 15.7 1.9 1 1 0 1 1 1 1 Olfactory receptor TAS2R PF05296.11 001009242.1_22423001_1 - 0.00012 21.2 11.7 0.00082 18.4 4.3 2.1 2 0 0 2 2 2 2 Taste receptor protein (TAS2R) DUF4079 PF13301.4 001009242.1_22423001_1 - 4.5 7.3 7.7 20 5.2 3.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) DUF4407 PF14362.4 001009242.1_22423001_1 - 4.6 6.4 5.5 1.8 7.7 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) UPF0220 PF05255.9 001168785.1_40421001_1 - 8.4e-51 171.7 3.9 9.3e-51 171.5 3.9 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) Ion_trans PF00520.29 001081761.1_21029001_1 - 3.4e-227 750.1 89.9 8.2e-76 254.3 13.2 4.1 4 0 0 4 4 4 4 Ion transport protein Na_trans_assoc PF06512.11 001081761.1_21029001_1 - 4.4e-53 180.2 0.6 7.8e-52 176.2 0.1 2.3 2 0 0 2 2 2 1 Sodium ion transport-associated PKD_channel PF08016.10 001081761.1_21029001_1 - 3.3e-06 25.9 59.8 0.00037 19.1 0.2 8.5 6 3 2 8 8 8 7 Polycystin cation channel GPHH PF16905.3 001081761.1_21029001_1 - 0.00021 20.9 0.0 0.00054 19.6 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated IQ PF00612.25 001081761.1_21029001_1 - 0.0053 16.3 1.0 0.015 14.9 1.0 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif Lustrin_cystein PF14625.4 001081761.1_21029001_1 - 0.53 10.6 5.6 0.17 12.2 0.2 2.6 2 0 0 2 2 2 0 Lustrin, cysteine-rich repeated domain UQ_con PF00179.24 001078673.1_49821001_1 - 3.1e-53 179.0 0.0 3.5e-53 178.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.20 001078673.1_49821001_1 - 0.013 15.6 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.4 001078673.1_49821001_1 - 0.028 14.0 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B UEV PF05743.11 001078673.1_49821001_1 - 0.082 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 UEV domain GHMP_kinases_N PF00288.24 031063.1_45724001_1 - 1.7e-22 79.3 0.1 4.6e-22 77.9 0.1 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.11 031063.1_45724001_1 - 4.8e-05 23.5 0.2 4.8e-05 23.5 0.2 2.7 2 0 0 2 2 2 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.7 031063.1_45724001_1 - 0.0008 18.8 0.1 0.0014 18.0 0.1 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature Ion_trans PF00520.29 001082717.1_37924001_1 - 2.8e-43 147.8 14.3 4.2e-43 147.2 14.3 1.3 1 0 0 1 1 1 1 Ion transport protein DUF3399 PF11879.6 001082717.1_37924001_1 - 3.9e-43 145.9 5.8 9.6e-43 144.6 5.8 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3399) BTB_2 PF02214.20 001082717.1_37924001_1 - 6.3e-29 100.0 0.1 1.7e-28 98.7 0.1 1.8 1 0 0 1 1 1 1 BTB/POZ domain Shal-type PF11601.6 001082717.1_37924001_1 - 1.6e-14 53.0 12.0 3.1e-14 52.1 12.0 1.5 1 0 0 1 1 1 1 Shal-type voltage-gated potassium channels, N-terminal Ion_trans_2 PF07885.14 001082717.1_37924001_1 - 3.8e-13 49.1 5.9 3.8e-13 49.1 5.9 2.5 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.3 001082717.1_37924001_1 - 3e-05 23.9 0.0 0.00022 21.2 0.0 2.3 2 0 0 2 2 2 1 BTB/POZ domain PKD_channel PF08016.10 001082717.1_37924001_1 - 0.0051 15.4 9.5 0.0063 15.1 8.7 1.4 1 1 0 1 1 1 1 Polycystin cation channel Ribosomal_S19 PF00203.19 214334.1_49821001_3 - 1.7e-40 136.7 0.4 2.3e-40 136.2 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Prok_Ub PF14454.4 214334.1_49821001_3 - 0.022 14.3 0.1 0.054 13.0 0.1 1.6 1 0 0 1 1 1 0 Prokaryotic Ubiquitin MAP65_ASE1 PF03999.10 214334.1_49821001_3 - 0.031 12.9 0.8 0.035 12.7 0.8 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) LCAT PF02450.13 214334.1_49821001_3 - 0.15 11.1 0.1 0.2 10.6 0.1 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Metallophos PF00149.26 001101686.1_37926001_1 - 1.2e-33 117.2 0.5 1.8e-33 116.7 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 001101686.1_37926001_1 - 0.014 15.7 0.3 0.028 14.7 0.3 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain YqzH PF14164.4 001101686.1_37926001_1 - 1.5 8.8 3.9 1.1 9.2 2.1 1.7 2 0 0 2 2 2 0 YqzH-like protein Tmemb_9 PF05434.9 001101686.1_37926001_3 - 1e-10 41.5 2.6 1.5e-10 41.0 2.6 1.2 1 0 0 1 1 1 1 TMEM9 zf-C2H2 PF00096.24 057211.1_45726001_1 - 1.5e-13 50.2 22.6 0.00021 21.4 1.1 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 057211.1_45726001_1 - 1.8e-12 46.9 30.0 3.4e-07 30.3 2.8 4.7 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 057211.1_45726001_1 - 4.9e-07 29.9 20.1 0.0056 17.3 2.8 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger FOXP-CC PF16159.3 057211.1_45726001_1 - 0.051 14.1 5.9 0.13 12.7 0.3 3.1 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-met PF12874.5 057211.1_45726001_1 - 0.31 11.3 11.1 0.19 12.0 0.7 3.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.3 057211.1_45726001_1 - 0.37 11.0 5.4 0.87 9.8 5.1 1.8 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.4 057211.1_45726001_1 - 0.93 9.4 13.5 0.048 13.5 1.1 3.5 3 1 0 3 3 3 0 C2H2-type zinc finger IBR PF01485.19 057211.1_45726001_1 - 1.7 8.8 6.2 7.9 6.7 6.2 2.1 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain zf-C2H2_jaz PF12171.6 057211.1_45726001_1 - 1.7 8.9 5.0 8.1 6.7 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 057211.1_45726001_1 - 4.1 7.6 8.6 0.82 9.9 2.3 2.4 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-CCCH_2 PF14608.4 138920.1_45725001_2 - 3.4e-16 58.9 58.4 0.00045 20.5 4.2 5.6 5 0 0 5 5 5 5 RNA-binding, Nab2-type zinc finger PWI PF01480.15 138920.1_45725001_2 - 0.026 14.7 0.0 0.054 13.7 0.0 1.5 1 0 0 1 1 1 0 PWI domain zf-TAZ PF02135.14 138920.1_45725001_2 - 1.5 9.2 19.3 0.3 11.4 2.5 2.4 2 0 0 2 2 2 0 TAZ zinc finger Ion_trans_N PF08412.8 001082063.1_37927001_1 - 6e-21 73.7 0.1 1.2e-20 72.7 0.1 1.5 1 0 0 1 1 1 1 Ion transport protein N-terminal cNMP_binding PF00027.27 001082063.1_37927001_1 - 1.2e-17 63.6 0.0 2.2e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.14 001082063.1_37927001_1 - 0.0036 17.1 0.2 0.014 15.2 0.2 2.0 1 0 0 1 1 1 1 Ion channel CDC37_M PF08565.9 053743.1_45724001_1 - 1.4e-26 92.6 1.9 1.8e-26 92.2 0.9 1.7 1 1 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_N PF03234.12 053743.1_45724001_1 - 2.3e-15 57.5 9.9 2.3e-15 57.5 9.9 2.6 1 1 1 2 2 2 1 Cdc37 N terminal kinase binding CDC37_C PF08564.8 053743.1_45724001_1 - 2.5e-15 56.3 0.0 2.5e-15 56.3 0.0 2.9 3 1 1 4 4 4 1 Cdc37 C terminal domain HTH_Tnp_1 PF01527.18 053743.1_45724001_1 - 0.51 10.6 5.2 3.8 7.8 5.2 2.4 1 1 0 1 1 1 0 Transposase Med4 PF10018.7 053743.1_45724001_1 - 0.96 9.0 6.5 0.61 9.6 3.5 2.1 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF4482 PF14818.4 053743.1_45724001_1 - 6 7.6 19.3 27 5.5 19.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4482) SMN PF06003.10 001009328.1_22423001_3 - 1.4e-106 355.4 9.1 1.9e-106 355.0 9.1 1.1 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) TUDOR PF00567.22 001009328.1_22423001_3 - 0.0033 17.3 0.1 0.0054 16.6 0.1 1.2 1 0 0 1 1 1 1 Tudor domain Voltage_CLC PF00654.18 001082751.1_37927001_2 - 3.5e-93 312.5 26.5 3.5e-93 312.5 26.5 1.8 1 1 1 2 2 2 1 Voltage gated chloride channel CBS PF00571.26 001082751.1_37927001_2 - 0.00094 19.5 0.9 0.29 11.5 0.1 2.5 2 0 0 2 2 2 2 CBS domain LBP_BPI_CETP PF01273.23 194357.1_32924001_3 - 1.8e-33 115.4 1.1 1.8e-33 115.4 1.1 2.0 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.15 194357.1_32924001_3 - 3.7e-20 72.3 2.2 6.2e-20 71.5 2.2 1.3 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain 7tm_1 PF00001.19 001009047.1_39723001_2 - 1.8e-51 174.8 16.5 3.9e-51 173.7 16.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CXCR4_N PF12109.6 001009047.1_39723001_2 - 8.2e-16 57.8 3.6 1.3e-15 57.2 3.6 1.3 1 0 0 1 1 1 1 CXCR4 Chemokine receptor N terminal 7TM_GPCR_Srsx PF10320.7 001009047.1_39723001_2 - 2.8e-06 26.8 15.5 3.8e-06 26.3 15.5 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TctB PF07331.9 001009047.1_39723001_2 - 0.84 9.8 9.0 0.38 10.9 1.5 2.4 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family COX2_TM PF02790.13 001009047.1_39723001_2 - 3.6 7.7 7.6 0.4 10.7 0.1 2.8 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain Sulfatase PF00884.21 213955.1_49825001_1 - 4e-88 295.6 0.0 5.3e-88 295.2 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.4 213955.1_49825001_1 - 8e-31 107.2 0.0 1.3e-30 106.5 0.0 1.3 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.20 213955.1_49825001_1 - 2.9e-07 30.3 0.0 3.1e-06 26.9 0.0 2.0 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase KH_1 PF00013.27 057141.1_45726001_1 - 1.1e-42 143.5 13.9 8.9e-20 70.2 1.9 3.3 3 0 0 3 3 3 3 KH domain ROKNT PF08067.9 057141.1_45726001_1 - 2.6e-26 91.4 9.8 4.2e-26 90.8 9.8 1.3 1 0 0 1 1 1 1 ROKNT (NUC014) domain KH_2 PF07650.15 057141.1_45726001_1 - 3e-13 49.2 6.8 0.0013 18.4 0.4 3.7 3 1 1 4 4 4 3 KH domain KH_4 PF13083.4 057141.1_45726001_1 - 6e-08 32.3 5.3 1.1e-05 25.1 0.0 3.2 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 057141.1_45726001_1 - 0.00079 19.3 5.5 0.49 10.4 0.1 3.5 3 1 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.3 057141.1_45726001_1 - 0.069 13.1 0.0 2.5 8.0 0.0 2.4 2 0 0 2 2 2 0 KH-like RNA-binding domain DJ-1_PfpI PF01965.22 057141.1_45726001_1 - 0.14 11.8 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family Integrin_beta PF00362.16 153720.1_45725001_3 - 2.2e-111 371.4 0.0 3.4e-111 370.7 0.0 1.3 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_B_tail PF07965.10 153720.1_45725001_3 - 1.5e-22 79.8 10.1 1.5e-22 79.8 10.1 4.7 4 1 1 5 5 5 1 Integrin beta tail domain Integrin_b_cyt PF08725.9 153720.1_45725001_3 - 3.6e-22 77.6 1.3 3.6e-22 77.6 1.3 1.9 2 0 0 2 2 2 1 Integrin beta cytoplasmic domain PSI_integrin PF17205.1 153720.1_45725001_3 - 1.1e-10 41.0 10.1 1.1e-10 41.0 10.1 4.9 5 2 1 6 6 6 1 Integrin plexin domain EGF_2 PF07974.11 153720.1_45725001_3 - 4.3e-10 39.6 99.2 0.0001 22.5 10.8 6.4 5 2 1 6 6 6 4 EGF-like domain Hormone_6 PF00236.16 001032990.1_32322001_2 - 1.3e-52 175.6 11.2 2.1e-52 174.9 11.2 1.4 1 0 0 1 1 1 1 Glycoprotein hormone DUF1218 PF06749.10 001032990.1_32322001_2 - 0.13 12.7 5.7 0.64 10.4 4.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1218) Cyclophil_like PF04126.11 001032990.1_32322001_3 - 0.058 13.1 0.0 0.083 12.6 0.0 1.2 1 0 0 1 1 1 0 Cyclophilin-like KCNQ_channel PF03520.12 133322.1_45729001_3 - 1.2e-88 295.8 0.1 1.7e-88 295.3 0.1 1.2 1 0 0 1 1 1 1 KCNQ voltage-gated potassium channel KCNQC3-Ank-G_bd PF11956.6 133322.1_45729001_3 - 2.6e-46 156.0 0.5 5.4e-46 155.0 0.5 1.5 1 0 0 1 1 1 1 Ankyrin-G binding motif of KCNQ2-3 KCNQ2_u3 PF16642.3 133322.1_45729001_3 - 1e-34 119.3 11.9 2.7e-34 117.9 11.9 1.8 1 0 0 1 1 1 1 Unstructured region on Potassium channel subunit alpha KvLQT2 Ion_trans PF00520.29 133322.1_45729001_3 - 2.3e-29 102.2 7.2 3.6e-29 101.6 7.2 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.14 133322.1_45729001_3 - 9.5e-13 47.8 3.3 2.5e-12 46.5 3.3 1.7 1 0 0 1 1 1 1 Ion channel ABC2_membrane_5 PF13346.4 133322.1_45729001_3 - 7.1 6.0 7.3 0.9 8.9 0.5 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein IATP PF04568.10 001097486.1_49822001_1 - 6.1e-17 61.7 3.2 9.8e-17 61.1 3.2 1.4 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP Cep57_MT_bd PF06657.11 001097486.1_49822001_1 - 0.016 15.5 2.8 0.025 14.9 2.8 1.3 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 DivIC PF04977.13 001097486.1_49822001_1 - 0.02 14.5 3.3 0.02 14.5 3.3 2.1 1 1 1 2 2 2 0 Septum formation initiator HIP1_clath_bdg PF16515.3 001097486.1_49822001_1 - 0.027 15.0 4.5 0.043 14.3 4.5 1.2 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 HemX PF04375.12 001097486.1_49822001_1 - 0.027 13.7 0.2 0.032 13.4 0.2 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Ion_trans PF00520.29 001082118.1_37924001_1 - 8.8e-43 146.1 11.6 1.2e-42 145.7 11.6 1.2 1 0 0 1 1 1 1 Ion transport protein DUF3399 PF11879.6 001082118.1_37924001_1 - 2.3e-41 140.2 9.1 5.6e-41 139.0 9.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3399) BTB_2 PF02214.20 001082118.1_37924001_1 - 1.5e-28 98.8 0.1 5e-28 97.2 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain Shal-type PF11601.6 001082118.1_37924001_1 - 2e-13 49.5 14.9 4.4e-13 48.4 14.9 1.6 1 0 0 1 1 1 1 Shal-type voltage-gated potassium channels, N-terminal Ion_trans_2 PF07885.14 001082118.1_37924001_1 - 2.1e-13 49.9 6.0 2.1e-13 49.9 6.0 2.5 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.3 001082118.1_37924001_1 - 2.9e-05 24.0 0.0 0.00023 21.1 0.0 2.4 2 0 0 2 2 2 1 BTB/POZ domain PKD_channel PF08016.10 001082118.1_37924001_1 - 0.00086 18.0 5.8 0.0015 17.2 5.8 1.3 1 0 0 1 1 1 1 Polycystin cation channel Cytochrom_B_C PF00032.15 001082118.1_37924001_1 - 2.8 8.2 5.9 2.2 8.5 0.9 2.4 1 1 1 2 2 2 0 Cytochrome b(C-terminal)/b6/petD C9orf72-like PF15019.4 001007702.1_45727001_1 - 9.4e-95 316.6 0.0 1.3e-94 316.2 0.0 1.2 1 0 0 1 1 1 1 C9orf72-like protein family OAD_gamma PF04277.11 017187.2_45723001_1 - 1 9.9 3.3 1.8 9.0 3.3 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain HMG_box_2 PF09011.8 017187.2_45723001_3 - 7.1e-40 135.3 15.0 2.8e-27 95.0 6.7 2.8 3 0 0 3 3 3 2 HMG-box domain HMG_box PF00505.17 017187.2_45723001_3 - 1.7e-39 133.9 13.6 4.6e-26 90.9 1.8 3.2 3 0 0 3 3 3 2 HMG (high mobility group) box CENP-B_dimeris PF09026.8 017187.2_45723001_3 - 9.1 6.6 15.5 17 5.7 15.5 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Citrate_synt PF00285.19 214276.1_49823001_1 - 2.6e-106 355.6 0.0 3.3e-106 355.3 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain PAS_3 PF08447.10 214276.1_49823001_1 - 0.055 13.6 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 PAS fold Queuosine_synth PF02547.13 214276.1_49823001_1 - 0.071 12.1 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein Tubulin PF00091.23 199094.2_45724001_2 - 9.9e-69 231.4 0.0 1.5e-68 230.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 199094.2_45724001_2 - 9.9e-43 145.2 0.1 1.5e-42 144.7 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 199094.2_45724001_2 - 1.4e-05 25.2 0.0 3.3e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.4 199094.2_45724001_2 - 0.0081 15.7 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.4 199094.2_45724001_2 - 0.018 14.1 0.0 0.038 13.1 0.0 1.5 1 0 0 1 1 1 0 Tubulin like LEDGF PF11467.6 001009372.1_22424001_1 - 9.8e-30 102.5 4.3 9.8e-30 102.5 4.3 2.4 2 0 0 2 2 2 1 Lens epithelium-derived growth factor (LEDGF) PWWP PF00855.15 001009372.1_22424001_1 - 5.5e-14 52.3 0.1 5.5e-14 52.3 0.1 4.5 4 2 0 4 4 4 1 PWWP domain Pkinase PF00069.23 199501.1_45725001_1 - 3e-78 262.7 0.0 4.7e-78 262.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 199501.1_45725001_1 - 6.6e-35 120.5 0.0 1e-34 119.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 199501.1_45725001_1 - 0.016 14.4 0.0 0.23 10.6 0.0 2.3 2 1 0 2 2 2 0 Kinase-like APH PF01636.21 199501.1_45725001_1 - 0.055 13.3 0.0 0.096 12.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Frtz PF11768.6 001127537.1_45726001_3 - 1.2e-263 875.2 0.0 1.5e-263 875.0 0.0 1.0 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz HPS3_N PF14761.4 001127537.1_45726001_3 - 0.04 13.4 0.9 0.16 11.5 0.8 1.9 1 1 1 2 2 2 0 Hermansky-Pudlak syndrome 3 Pkinase PF00069.23 173142.1_45723001_3 - 1.1e-44 152.7 0.0 1.4e-44 152.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 173142.1_45723001_3 - 1.6e-26 93.0 0.0 2.1e-26 92.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 173142.1_45723001_3 - 0.00093 18.5 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Aminotran_5 PF00266.17 001042566.1_22424001_1 - 2.1e-63 214.4 0.0 2.5e-63 214.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.19 001042566.1_22424001_1 - 0.0002 20.6 0.0 0.00081 18.5 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class I and II Metallophos PF00149.26 017374.3_32924001_3 - 2.1e-34 119.7 0.5 3.1e-34 119.1 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 017374.3_32924001_3 - 0.013 15.8 0.3 0.027 14.8 0.3 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain BK_channel_a PF03493.16 001082070.1_37929001_2 - 7.8e-33 112.5 0.2 1.8e-32 111.4 0.2 1.7 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.29 001082070.1_37929001_2 - 8.3e-18 64.4 20.1 1.9e-17 63.2 20.1 1.5 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.14 001082070.1_37929001_2 - 8.4e-14 51.2 4.1 8.4e-14 51.2 4.1 2.6 2 0 0 2 2 2 1 Ion channel TrkA_N PF02254.16 001082070.1_37929001_2 - 2.2e-05 24.6 0.0 0.00018 21.6 0.0 2.3 3 0 0 3 3 3 1 TrkA-N domain Lig_chan PF00060.24 001082070.1_37929001_2 - 0.16 11.7 3.9 0.69 9.6 1.1 2.6 2 0 0 2 2 2 0 Ligand-gated ion channel IMPDH PF00478.23 199099.2_45724001_1 - 9.8e-140 465.3 2.3 1.1e-139 465.1 2.3 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.13 199099.2_45724001_1 - 2.6e-14 53.2 0.8 2.7e-08 33.4 0.4 2.2 2 0 0 2 2 2 2 Nitronate monooxygenase CBS PF00571.26 199099.2_45724001_1 - 1.3e-12 47.8 0.5 1e-05 25.7 0.1 2.6 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.16 199099.2_45724001_1 - 1.1e-10 40.9 0.3 1.8e-10 40.3 0.3 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase His_biosynth PF00977.19 199099.2_45724001_1 - 1.1e-06 28.2 1.2 0.00032 20.1 0.1 2.3 1 1 1 2 2 2 2 Histidine biosynthesis protein NanE PF04131.12 199099.2_45724001_1 - 5.6e-05 22.3 0.1 0.00013 21.1 0.1 1.5 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase ThiG PF05690.12 199099.2_45724001_1 - 0.00041 19.6 1.4 0.0015 17.7 1.2 2.0 1 1 0 1 1 1 1 Thiazole biosynthesis protein ThiG Dus PF01207.15 199099.2_45724001_1 - 0.0025 16.8 0.7 0.26 10.2 0.0 2.2 1 1 0 2 2 2 2 Dihydrouridine synthase (Dus) Glu_synthase PF01645.15 199099.2_45724001_1 - 0.02 13.9 0.8 0.043 12.8 0.8 1.5 1 0 0 1 1 1 0 Conserved region in glutamate synthase G3P_antiterm PF04309.10 199099.2_45724001_1 - 0.036 13.4 0.4 1.1 8.5 0.0 2.4 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator DUF561 PF04481.10 199099.2_45724001_1 - 0.039 13.0 0.4 0.082 11.9 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF561) Aldolase PF01081.17 199099.2_45724001_1 - 0.13 11.5 1.7 4.6 6.5 0.1 3.0 4 0 0 4 4 4 0 KDPG and KHG aldolase Adap_comp_sub PF00928.19 001037977.1_45723001_1 - 1.2e-61 208.2 0.0 1.5e-61 208.0 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.18 001037977.1_45723001_1 - 7.7e-06 25.8 0.0 1.5e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain MIF PF01187.16 001078655.1_39521001_1 - 8.1e-55 183.9 0.0 9e-55 183.7 0.0 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Tautomerase PF01361.19 001078655.1_39521001_1 - 0.041 13.7 0.0 6.2 6.7 0.0 2.2 2 0 0 2 2 2 0 Tautomerase enzyme Pkinase_Tyr PF07714.15 031564.1_45727001_2 - 3e-98 328.1 0.0 4.3e-98 327.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.17 031564.1_45727001_2 - 1e-69 234.0 0.1 2.1e-69 233.0 0.1 1.6 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.23 031564.1_45727001_2 - 8.5e-48 162.9 0.0 1.4e-47 162.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 031564.1_45727001_2 - 3e-31 107.5 6.7 1.7e-15 57.0 0.7 3.4 4 0 0 4 4 3 2 Fibronectin type III domain EphA2_TM PF14575.4 031564.1_45727001_2 - 4.7e-22 78.5 0.0 2e-21 76.4 0.0 2.1 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain SAM_2 PF07647.15 031564.1_45727001_2 - 3.7e-14 52.4 0.0 8.6e-14 51.3 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 031564.1_45727001_2 - 3.1e-13 49.8 0.0 5.5e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pur_ac_phosph_N PF16656.3 031564.1_45727001_2 - 6e-07 29.8 0.4 9.6e-05 22.8 0.3 2.7 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Ephrin_rec_like PF07699.11 031564.1_45727001_2 - 4.6e-06 26.2 3.9 4.6e-06 26.2 3.9 2.8 2 1 0 2 2 2 1 Putative ephrin-receptor like fn3_2 PF16893.3 031564.1_45727001_2 - 0.00024 21.0 0.6 0.28 11.2 0.0 2.9 3 0 0 3 3 2 2 Fibronectin type III domain DUF2369 PF10179.7 031564.1_45727001_2 - 0.00095 19.5 0.6 1.4 9.3 0.0 2.5 1 1 1 2 2 2 2 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 031564.1_45727001_2 - 0.0013 18.9 0.0 0.33 11.2 0.1 3.5 4 0 0 4 4 3 1 Interferon-alpha/beta receptor, fibronectin type III Kdo PF06293.12 031564.1_45727001_2 - 0.015 14.6 0.0 0.024 13.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TMEM154 PF15102.4 031564.1_45727001_2 - 0.053 13.3 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family SusE PF14292.4 031564.1_45727001_2 - 0.054 13.8 0.1 0.37 11.1 0.1 2.4 2 0 0 2 2 2 0 SusE outer membrane protein Rax2 PF12768.5 031564.1_45727001_2 - 0.087 12.3 0.1 0.65 9.4 0.0 2.1 2 0 0 2 2 2 0 Cortical protein marker for cell polarity cEGF PF12662.5 031564.1_45727001_2 - 0.34 10.8 7.1 5 7.0 0.3 2.9 2 0 0 2 2 2 0 Complement Clr-like EGF-like zinc_ribbon_5 PF13719.4 031564.1_45727001_2 - 3.5 7.3 7.2 13 5.5 0.2 3.6 3 0 0 3 3 3 0 zinc-ribbon domain EGF_3 PF12947.5 031564.1_45727001_2 - 9 6.5 12.1 10 6.3 2.3 3.0 2 0 0 2 2 2 0 EGF domain DUF3947 PF13135.4 001048188.1_49829001_1 - 2.2e-06 27.6 10.5 1.4 9.0 0.1 4.6 4 0 0 4 4 4 4 Protein of unknown function (DUF3947) Hydrophobin_2 PF06766.9 001048188.1_49829001_1 - 0.069 13.0 7.1 30 4.5 0.1 4.6 4 0 0 4 4 4 0 Fungal hydrophobin SRCR PF00530.16 001048188.1_49829001_3 - 1.5e-166 542.0 56.8 2.6e-33 114.4 5.9 5.6 5 0 0 5 5 5 5 Scavenger receptor cysteine-rich domain CUB PF00431.18 001048188.1_49829001_3 - 1.6e-58 195.6 0.4 1.2e-29 102.7 0.1 2.6 2 0 0 2 2 2 2 CUB domain Zona_pellucida PF00100.21 001048188.1_49829001_3 - 7.7e-47 160.0 10.7 7.7e-47 160.0 10.7 2.2 2 0 0 2 2 2 1 Zona pellucida-like domain SRCR_2 PF15494.4 001048188.1_49829001_3 - 7.1e-20 71.2 38.6 0.0012 19.2 0.5 5.8 5 0 0 5 5 5 5 Scavenger receptor cysteine-rich domain CUB_2 PF02408.18 001048188.1_49829001_3 - 6.8e-05 22.5 5.7 0.065 12.9 0.1 3.1 3 0 0 3 3 3 2 CUB-like domain DBD_Tnp_Mut PF03108.13 001048188.1_49829001_3 - 6.8 6.4 10.4 91 2.8 0.1 4.5 4 0 0 4 4 4 0 MuDR family transposase Hormone_6 PF00236.16 001009464.1_39522001_2 - 6.5e-53 176.6 11.8 8.8e-53 176.2 11.8 1.2 1 0 0 1 1 1 1 Glycoprotein hormone DUF1218 PF06749.10 001009464.1_39522001_2 - 0.6 10.5 4.9 2.4 8.6 3.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) ART PF01129.16 198735.2_45723001_1 - 1.2e-86 289.4 0.1 1.5e-86 289.1 0.1 1.1 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.12 198735.2_45723001_1 - 0.00092 18.5 0.0 0.011 15.0 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme COX5B PF01215.17 001007517.1_49821001_1 - 8.2e-35 119.2 0.0 1.1e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb zinc_ribbon_5 PF13719.4 001007517.1_49821001_1 - 0.0029 17.2 0.0 0.0059 16.2 0.0 1.5 1 0 0 1 1 1 1 zinc-ribbon domain DUF35_N PF12172.6 001007517.1_49821001_1 - 0.083 12.7 0.5 0.2 11.4 0.5 1.6 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) 7tm_1 PF00001.19 001114534.1_21022001_1 - 6.6e-30 104.1 26.3 2.7e-28 98.8 26.3 2.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001114534.1_21022001_1 - 3.5e-14 53.1 15.9 2.8e-12 46.8 14.4 2.6 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001114534.1_21022001_1 - 3.1e-08 33.2 20.5 2.6e-07 30.2 20.5 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001114534.1_21022001_1 - 1.3 8.1 22.3 0.067 12.4 15.0 2.2 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx MIF PF01187.16 001032915.1_29621001_1 - 1.7e-51 173.2 0.0 2e-51 173.0 0.0 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Kelch_1 PF01344.23 001032915.1_29621001_1 - 0.073 12.5 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Kelch motif MACPF PF01823.17 001081950.1_21026001_2 - 2.2e-32 112.7 0.3 3.4e-32 112.1 0.3 1.3 1 0 0 1 1 1 1 MAC/Perforin domain Ldl_recept_a PF00057.16 001081950.1_21026001_2 - 6.9e-10 38.9 15.9 6.9e-10 38.8 13.9 2.2 1 1 0 1 1 1 1 Low-density lipoprotein receptor domain class A TSP_1 PF00090.17 001081950.1_21026001_2 - 0.00095 19.2 4.3 0.00095 19.2 4.3 2.6 3 0 0 3 3 3 1 Thrombospondin type 1 domain DUF4517 PF15006.4 001081950.1_21026001_2 - 0.097 12.7 0.0 0.22 11.5 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4517) SH3_9 PF14604.4 001034954.1_26229001_1 - 7.6e-37 124.8 0.6 2.8e-14 52.6 0.1 3.6 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 001034954.1_26229001_1 - 2.3e-35 119.8 0.4 2.8e-10 39.5 0.0 3.6 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.15 001034954.1_26229001_1 - 2.9e-28 97.2 0.2 7.5e-12 44.6 0.0 3.6 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.14 001034954.1_26229001_1 - 7e-21 73.5 0.3 1.6e-20 72.4 0.3 1.6 1 0 0 1 1 1 1 Sorbin homologous domain NifU_N PF01592.14 001105936.1_45722001_3 - 7.4e-57 190.9 0.2 1e-56 190.4 0.2 1.2 1 0 0 1 1 1 1 NifU-like N terminal domain Myc_N PF01056.16 001142794.1_39723001_1 - 2.5e-116 389.0 8.1 2.5e-116 389.0 8.1 1.3 2 0 0 2 2 2 1 Myc amino-terminal region Myc-LZ PF02344.13 001142794.1_39723001_1 - 1.2e-15 57.1 12.7 1.2e-15 57.1 12.7 2.0 2 0 0 2 2 2 1 Myc leucine zipper domain HLH PF00010.24 001142794.1_39723001_1 - 2.9e-15 55.8 8.3 2.5e-14 52.8 1.5 2.9 3 0 0 3 3 3 2 Helix-loop-helix DNA-binding domain TRH PF05438.10 001142794.1_39723001_1 - 0.0024 17.5 0.1 0.0024 17.5 0.1 2.1 2 1 0 2 2 2 1 Thyrotropin-releasing hormone (TRH) EamA PF00892.18 001133061.1_43527001_2 - 1.5e-08 34.8 45.7 1.1e-05 25.4 6.4 3.7 4 0 0 4 4 4 3 EamA-like transporter family BRI3BP PF14965.4 001081993.1_37924001_3 - 2.6e-55 186.6 7.9 4.4e-55 185.8 7.9 1.4 1 0 0 1 1 1 1 Negative regulator of p53/TP53 Mog1 PF04603.10 001105790.1_45722001_1 - 1.7e-37 128.7 0.0 2e-37 128.5 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein IPK PF03770.14 001082377.1_37924001_3 - 1.8e-61 207.3 0.0 3.6e-61 206.4 0.0 1.5 1 0 0 1 1 1 1 Inositol polyphosphate kinase Sugar_tr PF00083.22 001009770.1_39528001_2 - 3.7e-159 530.3 23.9 4.7e-159 529.9 23.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001009770.1_39528001_2 - 3e-19 69.0 20.9 3e-19 69.0 20.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_2 PF04550.10 001009770.1_39528001_2 - 0.61 10.4 5.3 1.2 9.4 4.7 1.9 1 1 0 1 1 1 0 Phage holin family 2 PAF-AH_p_II PF03403.11 177932.2_45723001_3 - 2.1e-158 526.7 0.0 2.4e-158 526.5 0.0 1.0 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.5 177932.2_45723001_3 - 3.9e-07 29.1 0.0 1.9e-06 26.8 0.0 1.9 1 1 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.19 177932.2_45723001_3 - 8.5e-07 28.5 0.1 6.2e-06 25.7 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.6 177932.2_45723001_3 - 1.2e-06 27.9 0.1 0.024 13.8 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.16 177932.2_45723001_3 - 1.6e-05 24.4 0.0 5.3e-05 22.7 0.0 1.7 1 1 0 1 1 1 1 Dienelactone hydrolase family Chlorophyllase PF07224.9 177932.2_45723001_3 - 1.7e-05 23.9 0.0 0.14 11.0 0.0 2.4 2 0 0 2 2 2 2 Chlorophyllase Esterase PF00756.18 177932.2_45723001_3 - 0.00013 21.6 0.0 0.0046 16.5 0.0 2.2 2 0 0 2 2 2 1 Putative esterase Abhydrolase_2 PF02230.14 177932.2_45723001_3 - 0.0027 17.4 0.0 0.036 13.7 0.0 2.3 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.5 177932.2_45723001_3 - 0.0037 17.8 0.1 0.011 16.3 0.1 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family Lipase_3 PF01764.23 177932.2_45723001_3 - 0.0064 16.2 0.5 0.014 15.1 0.2 1.7 2 0 0 2 2 2 1 Lipase (class 3) AXE1 PF05448.10 177932.2_45723001_3 - 0.0089 14.6 0.0 0.43 9.1 0.0 2.1 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.11 177932.2_45723001_3 - 0.0098 15.6 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.5 177932.2_45723001_3 - 0.02 14.5 0.0 0.11 12.0 0.0 2.1 3 0 0 3 3 3 0 Alpha/beta hydrolase family Peptidase_S15 PF02129.16 177932.2_45723001_3 - 0.053 13.0 0.1 0.19 11.1 0.0 1.8 1 1 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.18 177932.2_45723001_3 - 0.096 12.2 0.3 1.1 8.7 0.1 2.6 2 1 0 3 3 3 0 alpha/beta hydrolase fold HLH PF00010.24 012797.2_45722001_1 - 1.8e-12 46.9 0.0 3.1e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Dsl1_N PF11988.6 012797.2_45722001_1 - 0.059 12.2 0.1 0.081 11.7 0.1 1.1 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 N terminal Tfb2 PF03849.12 001045503.1_39723001_1 - 4.1e-137 456.8 0.0 5.4e-137 456.4 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Helicase_C_3 PF13625.4 001045503.1_39723001_1 - 8.3e-06 25.8 0.1 6.1e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SinI PF08671.8 001045503.1_39723001_1 - 0.16 11.7 0.4 1.3 8.7 0.0 2.5 2 0 0 2 2 2 0 Anti-repressor SinI TPR_1 PF00515.26 001002818.2_45723001_3 - 1.9e-17 62.1 1.1 4.4e-07 29.3 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 001002818.2_45723001_3 - 1.5e-14 52.7 3.0 2.7e-05 23.8 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.4 001002818.2_45723001_3 - 1.1e-08 35.0 5.0 0.00025 21.5 0.5 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.4 001002818.2_45723001_3 - 2.1e-08 34.6 5.2 0.00016 22.2 0.2 3.0 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.4 001002818.2_45723001_3 - 1.5e-07 31.7 1.3 8.8e-05 22.8 0.3 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.4 001002818.2_45723001_3 - 8.5e-07 28.9 4.9 1.6e-06 28.1 1.2 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.4 001002818.2_45723001_3 - 1.4e-05 24.7 0.0 0.0019 18.1 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.4 001002818.2_45723001_3 - 1.6e-05 25.1 0.3 0.06 13.9 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.4 001002818.2_45723001_3 - 2.2e-05 24.5 0.3 0.097 12.8 1.2 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.4 001002818.2_45723001_3 - 0.00011 21.8 0.1 5.7 7.1 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.4 001002818.2_45723001_3 - 0.00036 20.0 0.2 0.021 14.4 0.1 2.7 2 0 0 2 2 2 1 TPR repeat TPR_17 PF13431.4 001002818.2_45723001_3 - 0.0013 18.9 0.2 0.064 13.5 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 001002818.2_45723001_3 - 0.0031 17.4 0.1 0.049 13.6 0.0 2.4 1 1 1 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat BTAD PF03704.15 001002818.2_45723001_3 - 0.02 15.2 2.6 4.3 7.6 1.8 2.8 2 1 0 2 2 2 0 Bacterial transcriptional activator domain TPR_10 PF13374.4 001002818.2_45723001_3 - 0.14 12.0 0.6 13 5.7 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.12 001002818.2_45723001_3 - 1.6 9.5 12.0 2.3 9.0 0.8 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Endosulfine PF04667.15 214174.1_49821001_1 - 7.7e-09 35.4 8.5 2.3e-08 33.9 8.3 1.9 1 1 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region MAS20 PF02064.13 214174.1_49821001_1 - 0.069 13.1 2.4 0.086 12.8 2.4 1.2 1 0 0 1 1 1 0 MAS20 protein import receptor Ntox30 PF15532.4 214174.1_49821001_1 - 0.072 13.3 0.0 0.12 12.6 0.0 1.3 1 1 0 1 1 1 0 Bacterial toxin 30 Ras PF00071.20 001044537.1_49822001_1 - 2.5e-57 192.9 0.1 3.1e-57 192.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001044537.1_49822001_1 - 1.2e-20 73.8 0.0 2.1e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001044537.1_49822001_1 - 1.2e-08 34.5 0.0 1.6e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001044537.1_49822001_1 - 4.7e-06 26.1 0.1 2.5e-05 23.8 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001044537.1_49822001_1 - 1.3e-05 25.1 0.0 0.043 13.6 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 001044537.1_49822001_1 - 0.00024 21.0 0.0 0.00039 20.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001044537.1_49822001_1 - 0.0043 16.5 0.0 0.028 13.8 0.0 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.16 001044537.1_49822001_1 - 0.11 11.6 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Septin 7tm_1 PF00001.19 001033912.1_39723001_1 - 9e-75 251.2 8.4 1.5e-74 250.5 8.4 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001033912.1_39723001_1 - 3.9e-10 39.4 18.8 1.6e-08 34.1 11.5 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001033912.1_39723001_1 - 4.7e-05 22.7 7.6 4.7e-05 22.7 7.6 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001033912.1_39723001_1 - 0.00021 21.0 6.0 0.00021 21.0 6.0 2.0 2 0 0 2 2 2 1 Olfactory receptor zf-H2C2_2 PF13465.4 031824.1_45728001_1 - 2.4e-46 154.1 100.6 1.6e-08 34.4 0.7 12.0 12 0 0 12 12 12 9 Zinc-finger double domain zf-C2H2 PF00096.24 031824.1_45728001_1 - 2e-30 103.4 105.3 0.00015 21.9 1.1 12.1 12 0 0 12 12 12 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 031824.1_45728001_1 - 1.1e-23 81.7 96.5 0.0087 16.7 2.7 11.8 11 0 0 11 11 11 10 C2H2-type zinc finger zf-H2C2_5 PF13909.4 031824.1_45728001_1 - 4.3e-16 58.2 81.0 1.8e-06 27.5 0.6 10.4 10 0 0 10 10 10 5 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 031824.1_45728001_1 - 5.5e-07 29.6 58.6 0.04 14.1 0.2 11.2 9 1 2 11 11 11 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 031824.1_45728001_1 - 0.012 15.8 2.5 0.012 15.8 2.5 9.7 11 0 0 11 11 11 0 Zinc-finger of C2H2 type Actin_micro PF17003.3 031824.1_45728001_1 - 2 7.3 37.2 2.5 7.1 1.5 6.7 1 1 2 4 4 4 0 Putative actin-like family BTB PF00651.29 013915.3_32929001_2 - 1e-26 93.2 1.3 1.7e-26 92.5 1.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 013915.3_32929001_2 - 2.3e-12 46.5 31.8 0.0027 18.0 2.4 5.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 013915.3_32929001_2 - 2.9e-12 46.2 34.9 0.0011 19.5 3.0 6.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-H2C2_2 PF13465.4 013915.3_32929001_2 - 4e-12 45.9 26.5 3.9e-07 30.1 2.0 5.9 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_jaz PF12171.6 013915.3_32929001_2 - 2.7e-06 27.4 6.6 0.0054 16.9 0.0 4.1 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 013915.3_32929001_2 - 0.0065 16.1 12.3 0.94 9.2 0.4 4.0 3 0 0 3 3 3 3 zinc-finger C2H2-type zf-met PF12874.5 013915.3_32929001_2 - 0.0091 16.2 0.2 0.0091 16.2 0.2 4.2 4 0 0 4 4 3 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 013915.3_32929001_2 - 0.016 15.0 20.4 0.66 9.9 1.2 4.9 4 0 0 4 4 4 0 C2H2-type zinc finger CpXC PF14353.4 013915.3_32929001_2 - 0.19 11.7 4.8 1.3 8.9 0.4 2.4 2 0 0 2 2 2 0 CpXC protein GAGA PF09237.9 013915.3_32929001_2 - 1.9 8.3 7.3 2 8.2 0.2 3.2 2 1 1 3 3 3 0 GAGA factor Zn-ribbon_8 PF09723.8 013915.3_32929001_2 - 5.4 7.1 7.2 1.4 9.0 0.9 2.9 2 1 1 3 3 3 0 Zinc ribbon domain zf-LYAR PF08790.9 013915.3_32929001_2 - 6.5 6.6 8.8 2.1 8.2 0.5 3.5 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger LIM PF00412.20 001134178.2_43527001_1 - 3.9e-28 97.3 22.1 8.2e-14 51.4 8.1 2.6 2 0 0 2 2 2 2 LIM domain Androgen_recep PF02166.14 001009012.1_39726001_1 - 5.2e-257 853.2 45.3 5.2e-257 853.2 45.3 1.8 2 0 0 2 2 2 1 Androgen receptor Hormone_recep PF00104.28 001009012.1_39726001_1 - 5.3e-31 107.7 2.9 5.3e-31 107.7 2.9 1.7 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001009012.1_39726001_1 - 3.7e-27 94.5 14.4 9e-27 93.2 14.4 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) U3_snoRNA_assoc PF08297.9 001009012.1_39726001_1 - 0.12 13.0 4.7 0.28 11.8 4.7 1.6 1 0 0 1 1 1 0 U3 snoRNA associated Presenilin PF01080.15 001009012.1_39726001_1 - 0.51 8.9 5.6 0.8 8.2 5.6 1.3 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.6 001009012.1_39726001_1 - 1.4 7.5 5.8 2.3 6.8 5.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 BRF1 PF07741.11 001009012.1_39726001_1 - 2.1 8.6 6.5 90 3.4 0.0 2.3 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Spt20 PF12090.6 001009012.1_39726001_1 - 3.1 7.2 28.6 0.23 10.9 23.2 1.8 2 0 0 2 2 2 0 Spt20 family Trypan_PARP PF05887.9 001009012.1_39726001_1 - 4.7 7.1 9.9 0.74 9.7 5.6 1.9 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) eIF-3_zeta PF05091.10 001009012.1_39726001_1 - 6.7 5.4 9.3 10 4.8 9.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) IMUP PF15761.3 001009012.1_39726001_2 - 0.36 11.4 11.3 0.98 10.0 11.3 1.7 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.7 001009012.1_39726001_2 - 5.3 6.5 19.9 11 5.5 19.9 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein 7tm_1 PF00001.19 001081897.1_21025001_2 - 8e-58 195.6 13.0 1.1e-57 195.2 13.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001081897.1_21025001_2 - 7.3e-12 45.1 13.2 4.7e-11 42.4 13.2 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001081897.1_21025001_2 - 1.5e-08 34.6 11.7 4.3e-08 33.1 11.7 1.6 1 1 0 1 1 1 1 Olfactory receptor GPR_Gpa2_C PF11970.6 001081897.1_21025001_2 - 0.035 14.0 0.5 0.1 12.6 0.5 1.8 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 C-term 7TM_GPCR_Srx PF10328.7 001081897.1_21025001_2 - 1.2 8.3 19.9 1.1 8.4 17.9 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF2417 PF10329.7 001081897.1_21025001_2 - 3.1 7.0 7.1 24 4.1 5.8 2.3 2 0 0 2 2 2 0 Region of unknown function (DUF2417) Nramp PF01566.16 001009345.1_39525001_3 - 1.2e-115 386.2 14.7 1.2e-115 386.2 14.7 1.9 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein UDG PF03167.17 001040691.1_32924001_3 - 1.3e-23 83.6 0.0 2.3e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Lipocalin PF00061.21 001009233.1_22422001_3 - 8.7e-29 100.4 0.5 1.1e-28 100.2 0.5 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family BioT2 PF15368.4 001003964.1_45724001_3 - 0.006 16.4 0.7 0.022 14.6 0.1 1.9 2 0 0 2 2 2 1 Spermatogenesis family BioT2 NACHT PF05729.10 001106291.1_45726001_3 - 2.6e-37 128.2 0.0 4.5e-37 127.4 0.0 1.4 1 0 0 1 1 1 1 NACHT domain PYRIN PF02758.14 001106291.1_45726001_3 - 9.7e-17 60.8 1.1 2.7e-16 59.4 0.3 2.1 2 0 0 2 2 2 1 PAAD/DAPIN/Pyrin domain NB-ARC PF00931.20 001106291.1_45726001_3 - 8.7e-05 21.5 0.0 0.0013 17.7 0.0 2.2 1 1 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.4 001106291.1_45726001_3 - 0.0017 18.6 0.0 0.027 14.7 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.4 001106291.1_45726001_3 - 0.0023 17.5 0.0 0.004 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.4 001106291.1_45726001_3 - 0.0037 17.2 0.0 0.0098 15.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA PF00004.27 001106291.1_45726001_3 - 0.016 15.5 0.0 0.033 14.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.4 001106291.1_45726001_3 - 0.039 14.0 0.3 0.076 13.0 0.3 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.15 001106291.1_45726001_3 - 0.044 13.7 0.0 0.093 12.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.20 001106291.1_45726001_3 - 0.072 13.4 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.4 001106291.1_45726001_3 - 0.074 13.3 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.17 001106291.1_45726001_3 - 0.082 12.3 0.1 0.15 11.5 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.10 001106291.1_45726001_3 - 0.084 12.0 0.0 0.18 11.0 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.4 001106291.1_45726001_3 - 0.088 12.9 0.0 0.88 9.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.4 001106291.1_45726001_3 - 0.1 12.0 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Glyco_hydro_30 PF02055.14 001008997.1_39724001_1 - 6.7e-197 653.3 0.1 8.3e-197 653.0 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.2 001008997.1_39724001_1 - 5.4e-15 55.2 0.0 9.5e-15 54.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain IFN-gamma PF00714.15 001081949.1_21022001_2 - 1.4e-74 248.3 4.8 1.8e-74 248.0 4.8 1.1 1 0 0 1 1 1 1 Interferon gamma API5 PF05918.9 001081949.1_21022001_2 - 0.00069 18.4 2.1 0.00093 18.0 0.7 1.7 1 1 1 2 2 2 1 Apoptosis inhibitory protein 5 (API5) DUF1987 PF09345.8 001081949.1_21022001_2 - 0.025 14.4 1.3 0.26 11.1 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1987) PAS_3 PF08447.10 012780.1_45725001_3 - 6.9e-24 83.8 0.1 1.2e-17 63.9 0.0 2.8 3 0 0 3 3 3 2 PAS fold PAS PF00989.23 012780.1_45725001_3 - 5.2e-23 81.1 1.0 6.3e-15 55.0 0.0 3.0 3 0 0 3 3 3 2 PAS fold PAS_11 PF14598.4 012780.1_45725001_3 - 1.9e-21 76.1 0.4 7.3e-19 67.8 0.2 2.9 2 1 0 2 2 2 2 PAS domain HLH PF00010.24 012780.1_45725001_3 - 4.1e-15 55.4 1.1 9.2e-15 54.2 1.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 012780.1_45725001_3 - 2.1e-08 34.2 0.0 2.9e-05 24.1 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 012780.1_45725001_3 - 0.0015 18.6 0.0 0.87 9.7 0.0 2.6 2 0 0 2 2 2 2 PAS fold Trefoil PF00088.16 001130390.1_22421001_1 - 9.8e-16 57.2 8.6 1.5e-15 56.7 8.6 1.3 1 0 0 1 1 1 1 Trefoil (P-type) domain STAT_bind PF02864.13 214168.1_49825001_1 - 1.5e-102 342.6 1.2 1.5e-102 342.6 1.2 2.0 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 214168.1_49825001_1 - 2.7e-54 183.6 22.0 6.6e-54 182.3 22.0 1.7 1 0 0 1 1 1 1 STAT protein, all-alpha domain STAT_int PF02865.15 214168.1_49825001_1 - 1.5e-45 154.5 3.1 1.5e-45 154.5 3.1 3.1 3 1 1 4 4 4 1 STAT protein, protein interaction domain SH2 PF00017.22 214168.1_49825001_1 - 1.8e-11 43.8 0.0 1.4e-10 40.9 0.0 2.6 2 0 0 2 2 2 1 SH2 domain RPE65 PF03055.13 174453.2_06527001_2 - 2.1e-107 359.7 0.2 2.5e-107 359.5 0.2 1.1 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Sulfatase PF00884.21 001142259.1_22424001_1 - 4.3e-74 249.5 0.0 5.4e-74 249.2 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.20 001142259.1_22424001_1 - 8.2e-05 22.2 0.1 0.0019 17.8 0.1 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase MARVEL PF01284.21 001081986.1_37927001_1 - 1.5e-38 131.9 8.4 2.5e-38 131.2 8.4 1.4 1 0 0 1 1 1 1 Membrane-associating domain DUF2838 PF10998.6 001081986.1_37927001_1 - 0.034 14.3 0.5 0.069 13.3 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2838) Androgen_recep PF02166.14 001032911.1_29627001_3 - 9.2e-256 849.1 40.8 9.2e-256 849.1 40.8 1.6 2 0 0 2 2 2 1 Androgen receptor Hormone_recep PF00104.28 001032911.1_29627001_3 - 3.5e-31 108.3 2.9 6.2e-31 107.5 2.9 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001032911.1_29627001_3 - 4.8e-27 94.1 14.4 1e-26 93.0 14.4 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) MACPF PF01823.17 001009015.1_39726001_1 - 1.2e-46 159.3 2.3 1.4e-46 159.1 0.9 1.8 2 0 0 2 2 2 1 MAC/Perforin domain Sushi PF00084.18 001009015.1_39726001_1 - 1.3e-13 51.2 5.5 6e-09 36.3 1.2 3.8 4 0 0 4 4 4 2 Sushi repeat (SCR repeat) TSP_1 PF00090.17 001009015.1_39726001_1 - 9.8e-13 48.0 20.8 5e-09 36.1 0.7 5.7 6 1 0 6 6 6 3 Thrombospondin type 1 domain Kazal_2 PF07648.13 001009015.1_39726001_1 - 2e-10 40.5 4.0 2e-10 40.5 4.0 3.4 2 1 0 2 2 2 1 Kazal-type serine protease inhibitor domain Ldl_recept_a PF00057.16 001009015.1_39726001_1 - 2.4e-10 40.3 15.6 2.4e-10 40.3 15.6 5.2 5 0 0 5 5 5 1 Low-density lipoprotein receptor domain class A JmjC PF02373.20 182659.1_26229001_1 - 4.9e-34 117.1 1.4 1.6e-33 115.4 1.4 2.0 1 0 0 1 1 1 1 JmjC domain, hydroxylase TPR_1 PF00515.26 182659.1_26229001_1 - 9.5e-26 88.4 19.1 9.9e-06 25.0 0.0 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.15 182659.1_26229001_1 - 4.4e-15 54.4 18.9 0.095 12.7 0.1 8.6 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.4 182659.1_26229001_1 - 6.8e-14 50.7 17.0 0.0038 17.2 0.4 7.6 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.4 182659.1_26229001_1 - 1.5e-13 51.0 0.5 0.079 13.5 0.0 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.4 182659.1_26229001_1 - 5.3e-11 42.0 5.8 0.0059 16.8 0.0 4.7 6 0 0 6 6 3 3 Tetratricopeptide repeat TPR_12 PF13424.4 182659.1_26229001_1 - 5.1e-09 36.2 9.3 0.22 11.7 0.1 5.0 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.4 182659.1_26229001_1 - 1.1e-06 28.1 9.9 0.44 10.6 0.2 6.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.4 182659.1_26229001_1 - 1.2e-06 28.7 3.6 1.7 9.5 0.0 5.2 4 2 1 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.4 182659.1_26229001_1 - 1.3e-06 28.7 9.5 0.044 14.2 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.4 182659.1_26229001_1 - 0.00011 22.2 2.9 0.0085 16.1 0.1 3.8 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.4 182659.1_26229001_1 - 0.0019 17.7 12.8 0.1 12.1 0.0 6.0 3 2 3 6 6 6 2 TPR repeat TPR_6 PF13174.4 182659.1_26229001_1 - 0.054 14.0 10.4 2.9 8.6 0.1 6.8 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_15 PF13429.4 182659.1_26229001_1 - 0.092 11.8 6.9 0.32 10.0 2.7 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.5 182659.1_26229001_1 - 0.76 9.9 0.0 0.76 9.9 0.0 4.1 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.4 182659.1_26229001_1 - 2.8 7.2 11.6 4.8 6.4 0.3 3.2 2 1 0 3 3 3 0 Soluble NSF attachment protein, SNAP PAS_3 PF08447.10 022528.2_45725001_1 - 2.2e-22 79.0 0.0 9.4e-16 57.7 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 022528.2_45725001_1 - 6.8e-20 71.2 0.0 1.1e-15 57.6 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS PF00989.23 022528.2_45725001_1 - 2.7e-15 56.2 0.0 9.8e-07 28.6 0.0 2.3 2 0 0 2 2 2 2 PAS fold HIF-1 PF11413.6 022528.2_45725001_1 - 2.3e-13 49.2 5.7 4.6e-13 48.2 5.7 1.6 1 0 0 1 1 1 1 Hypoxia-inducible factor-1 PAS_4 PF08448.8 022528.2_45725001_1 - 3e-08 33.7 0.0 0.0054 16.8 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.5 022528.2_45725001_1 - 3.9e-07 30.2 0.0 0.023 14.8 0.0 2.5 2 0 0 2 2 2 2 PAS domain HLH PF00010.24 022528.2_45725001_1 - 0.0095 15.8 0.3 0.022 14.6 0.3 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PTR2 PF00854.19 001082700.1_37929001_2 - 1.1e-132 442.5 7.9 1.1e-120 402.9 1.5 2.2 2 0 0 2 2 2 2 POT family DUF2207 PF09972.7 001082700.1_37929001_2 - 7.9 5.0 6.8 16 4.0 0.1 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) SNARE PF05739.17 031656.2_45722001_2 - 7.1e-09 35.4 2.6 1.3e-08 34.5 2.6 1.5 1 0 0 1 1 1 1 SNARE domain Use1 PF09753.7 031656.2_45722001_2 - 0.019 14.5 4.0 0.039 13.5 4.0 1.6 1 1 0 1 1 1 0 Membrane fusion protein Use1 Otopetrin PF03189.11 031656.2_45722001_2 - 0.031 13.0 0.0 0.042 12.5 0.0 1.2 1 0 0 1 1 1 0 Otopetrin Prominin PF05478.9 031656.2_45722001_2 - 0.038 11.8 0.3 0.063 11.1 0.3 1.3 1 0 0 1 1 1 0 Prominin DUF2095 PF09868.7 031656.2_45722001_2 - 0.19 11.6 2.1 1.4 8.8 0.8 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2095) Apolipo_F PF15148.4 001024351.1_45723001_1 - 5.1e-88 293.7 0.0 6.4e-88 293.4 0.0 1.1 1 0 0 1 1 1 1 Apolipoprotein F B5 PF03484.13 001024351.1_45723001_1 - 0.025 14.8 0.0 0.052 13.7 0.0 1.5 1 1 0 1 1 1 0 tRNA synthetase B5 domain BicD PF09730.7 001108653.1_45729001_2 - 0 1147.9 66.6 0 1147.9 66.6 1.9 2 0 0 2 2 2 1 Microtubule-associated protein Bicaudal-D DUF1759 PF03564.13 001108653.1_45729001_2 - 0.0043 16.9 5.9 0.0043 16.9 5.9 5.8 4 2 0 6 6 6 1 Protein of unknown function (DUF1759) Mce4_CUP1 PF11887.6 001108653.1_45729001_2 - 3.7 6.8 8.7 11 5.2 0.3 2.8 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative Serum_albumin PF00273.18 001009961.2_22424001_2 - 6.1e-161 530.8 44.7 2e-60 203.4 9.9 3.0 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.8 001009961.2_22424001_2 - 3.2e-08 33.3 17.3 0.12 12.3 0.1 6.1 5 0 0 5 5 5 4 Vitamin D binding protein, domain III Glyco_transf_11 PF01531.14 001009120.1_39723001_1 - 3e-147 489.5 0.0 3.4e-147 489.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl transferase family 11 O-FucT PF10250.7 001009120.1_39723001_1 - 0.0049 16.5 0.4 0.018 14.6 0.3 1.7 1 1 1 2 2 2 1 GDP-fucose protein O-fucosyltransferase 7tm_1 PF00001.19 001009124.1_39723001_1 - 2.6e-70 236.6 15.8 4.3e-70 235.9 15.8 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009124.1_39723001_1 - 8.3e-10 38.3 13.5 1.2e-09 37.8 13.5 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001009124.1_39723001_1 - 7.8e-05 22.4 12.9 0.0002 21.0 12.9 1.8 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001009124.1_39723001_1 - 0.0044 16.2 11.9 0.0044 16.2 11.9 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Homeobox PF00046.27 005515.3_26225001_1 - 2.4e-21 75.1 6.6 3.8e-21 74.5 6.6 1.3 1 0 0 1 1 1 1 Homeobox domain QLQ PF08880.9 005515.3_26225001_1 - 0.0023 17.5 0.4 0.0046 16.6 0.4 1.5 1 0 0 1 1 1 1 QLQ Ribosomal_L22e PF01776.15 213987.1_49821001_2 - 1.6e-53 179.6 1.0 2e-53 179.3 1.0 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family TSC22 PF01166.16 001133484.1_43529001_2 - 6.2e-28 96.8 5.9 1.4e-27 95.6 5.9 1.7 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF972 PF06156.11 001133484.1_43529001_2 - 0.00096 19.6 1.3 0.0021 18.5 1.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF972) K-box PF01486.15 001133484.1_43529001_2 - 0.019 15.0 1.8 0.047 13.8 1.8 1.6 1 0 0 1 1 1 0 K-box region bZIP_2 PF07716.13 001133484.1_43529001_2 - 4.6 7.3 5.9 9.9 6.2 5.9 1.5 1 0 0 1 1 1 0 Basic region leucine zipper ZapB PF06005.10 001133484.1_43529001_2 - 4.9 7.5 13.8 0.1 12.9 6.1 2.1 2 0 0 2 2 2 0 Cell division protein ZapB Ribosomal_L44 PF00935.17 031105.2_45722001_2 - 4.1e-40 136.0 9.1 4.1e-40 136.0 9.1 1.7 1 1 1 2 2 2 1 Ribosomal protein L44 RnaseA PF00074.18 001009159.1_39721001_1 - 2.5e-34 118.3 0.4 2.8e-34 118.1 0.4 1.0 1 0 0 1 1 1 1 Pancreatic ribonuclease FGF PF00167.16 001033976.2_32322001_2 - 3.1e-42 143.5 0.0 3.6e-42 143.3 0.0 1.0 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 001033976.2_32322001_2 - 0.00022 21.3 0.2 0.065 13.3 0.1 1.6 1 1 1 2 2 2 2 Fascin domain IL1 PF00340.17 001033976.2_32322001_2 - 0.00031 20.3 0.0 0.00046 19.7 0.0 1.3 1 0 0 1 1 1 1 Interleukin-1 / 18 LELP1 PF15042.4 001033976.2_32322001_3 - 0.51 10.7 8.4 0.85 10.0 8.4 1.3 1 0 0 1 1 1 0 Late cornified envelope-like proline-rich protein 1 GATA PF00320.25 012764.1_45724001_3 - 1.1e-28 98.3 19.4 2.7e-14 52.3 5.8 2.6 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.10 012764.1_45724001_3 - 1.4e-05 24.4 7.3 0.021 14.2 1.5 2.8 2 0 0 2 2 2 2 TFIIB zinc-binding A2L_zn_ribbon PF08792.8 012764.1_45724001_3 - 0.0075 15.8 3.0 2.7 7.7 0.0 4.1 4 0 0 4 4 4 1 A2L zinc ribbon domain Zn-ribbon_8 PF09723.8 012764.1_45724001_3 - 0.019 14.9 3.0 1.4 9.0 0.2 2.9 2 0 0 2 2 2 0 Zinc ribbon domain ArfGap PF01412.16 012764.1_45724001_3 - 0.09 12.7 8.2 0.26 11.2 1.1 2.2 1 1 1 2 2 2 0 Putative GTPase activating protein for Arf DZR PF12773.5 012764.1_45724001_3 - 0.68 9.9 9.8 9.1 6.3 2.1 3.0 1 1 2 3 3 3 0 Double zinc ribbon eIF-5_eIF-2B PF01873.15 012764.1_45724001_3 - 0.98 9.2 6.6 7.5 6.3 0.3 2.2 2 0 0 2 2 2 0 Domain found in IF2B/IF5 DUF2387 PF09526.8 012764.1_45724001_3 - 1.1 9.3 6.2 12 6.0 0.2 3.2 1 1 2 3 3 3 0 Probable metal-binding protein (DUF2387) OrfB_Zn_ribbon PF07282.9 012764.1_45724001_3 - 1.3 8.9 7.1 3.8 7.4 0.8 2.5 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Auto_anti-p27 PF06677.10 012764.1_45724001_3 - 1.9 8.5 5.8 6 7.0 0.4 2.8 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) PTR2 PF00854.19 001082337.1_37926001_1 - 4.6e-151 503.0 15.0 2e-139 464.7 10.3 2.2 2 0 0 2 2 2 2 POT family MFS_2 PF13347.4 001082337.1_37926001_1 - 0.00022 19.8 5.9 0.00022 19.8 5.9 2.9 3 0 0 3 3 3 2 MFS/sugar transport protein AlgF PF11182.6 001082337.1_37926001_1 - 0.012 15.3 0.6 0.039 13.6 0.1 1.9 2 0 0 2 2 2 0 Alginate O-acetyl transferase AlgF DUF843 PF05814.9 001082337.1_37926001_1 - 0.092 12.6 0.5 0.38 10.6 0.0 2.3 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) DUF2207 PF09972.7 001082337.1_37926001_1 - 1.2 7.7 6.9 5.1 5.6 0.2 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Histone PF00125.22 022674.1_45722001_3 - 1.3e-18 67.5 0.0 1.7e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.3 022674.1_45722001_3 - 1.2e-12 47.1 0.5 2.7e-12 46.1 0.5 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.21 022674.1_45722001_3 - 0.021 15.0 0.0 0.033 14.3 0.0 1.3 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CBAH PF02275.16 001098560.1_39725001_1 - 8.7e-59 199.6 0.5 5.1e-58 197.1 0.5 1.9 1 1 0 1 1 1 1 Linear amide C-N hydrolases, choloylglycine hydrolase family NAAA-beta PF15508.4 001098560.1_39725001_1 - 6.6e-22 77.5 0.1 1.6e-21 76.2 0.1 1.7 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase AAT PF03417.14 001098560.1_39725001_1 - 0.02 14.5 0.0 0.033 13.7 0.0 1.3 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Exo_endo_phos PF03372.21 001082740.1_37923001_2 - 4.7e-06 26.7 0.0 6.8e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Voltage_CLC PF00654.18 001082361.1_37926001_3 - 5e-74 249.5 25.6 5e-74 249.5 25.6 1.5 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.26 001082361.1_37926001_3 - 5.3e-06 26.6 0.0 0.046 14.1 0.0 2.8 3 0 0 3 3 3 2 CBS domain Deltameth_res PF16020.3 001082361.1_37926001_3 - 0.32 10.7 1.2 4.4 7.1 0.0 3.1 2 0 0 2 2 2 0 Deltamethrin resistance RBP_receptor PF14752.4 022369.3_26226001_3 - 3e-258 858.3 5.5 3.5e-258 858.1 5.5 1.0 1 0 0 1 1 1 1 Retinol binding protein receptor SUR7 PF06687.10 022369.3_26226001_3 - 1.2 8.6 5.7 3.2 7.2 5.7 1.7 1 0 0 1 1 1 0 SUR7/PalI family SCP-1 PF05483.10 012810.1_45728001_1 - 0 1612.2 161.2 0 1611.8 161.2 1.1 1 0 0 1 1 1 1 Synaptonemal complex protein 1 (SCP-1) DUF16 PF01519.14 012810.1_45728001_1 - 0.012 16.0 10.6 0.012 16.0 10.6 9.3 2 1 7 9 9 9 0 Protein of unknown function DUF16 Tctex-1 PF03645.11 001009762.1_39525001_1 - 3.6e-25 88.0 0.7 5.4e-25 87.5 0.7 1.3 1 0 0 1 1 1 1 Tctex-1 family ubiquitin PF00240.21 214211.1_49822001_3 - 1.3e-34 117.6 0.3 1.8e-34 117.2 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.15 214211.1_49822001_3 - 8e-33 111.9 12.3 1.4e-32 111.1 12.3 1.4 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.6 214211.1_49822001_3 - 8.9e-17 60.6 0.4 1.5e-16 59.9 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 214211.1_49822001_3 - 9.7e-06 25.8 0.1 3.3e-05 24.1 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 214211.1_49822001_3 - 0.0071 16.3 0.1 0.013 15.4 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 214211.1_49822001_3 - 0.079 13.4 0.1 0.093 13.2 0.1 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain HLH PF00010.24 001033694.1_45729001_3 - 2.4e-16 59.3 0.7 6.9e-16 57.8 0.7 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF805 PF05656.12 001033694.1_45729001_3 - 0.21 11.9 4.2 0.64 10.3 4.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF805) Forkhead PF00250.16 004474.3_26229001_2 - 1.9e-36 124.1 0.0 2.7e-36 123.6 0.0 1.2 1 0 0 1 1 1 1 Forkhead domain 7tm_1 PF00001.19 001082349.1_37923001_3 - 4.5e-48 163.7 13.0 5.9e-48 163.3 13.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Rhodopsin_N PF10413.7 001082349.1_37923001_3 - 5.2e-25 86.8 2.9 5.2e-25 86.8 2.9 2.0 2 0 0 2 2 2 1 Amino terminal of the G-protein receptor rhodopsin 7TM_GPCR_Srv PF10323.7 001082349.1_37923001_3 - 2.7e-11 43.2 18.7 4.1e-11 42.6 18.7 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.7 001082349.1_37923001_3 - 3.6e-11 42.8 17.8 2.5e-10 40.0 17.8 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.7 001082349.1_37923001_3 - 6.4e-09 35.4 16.6 8.5e-09 35.0 16.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TAS2R PF05296.11 001082349.1_37923001_3 - 0.00012 21.2 11.9 0.00089 18.3 4.4 2.1 2 0 0 2 2 2 2 Taste receptor protein (TAS2R) 7tm_4 PF13853.4 001082349.1_37923001_3 - 0.00025 20.7 16.3 0.0014 18.3 16.3 1.9 1 1 0 1 1 1 1 Olfactory receptor DUF4407 PF14362.4 001082349.1_37923001_3 - 2.7 7.1 4.1 1.5 8.0 1.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF4079 PF13301.4 001082349.1_37923001_3 - 5.3 7.1 7.3 15 5.6 3.6 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) 7TM_GPCR_Srh PF10318.7 001082349.1_37923001_3 - 5.9 5.7 29.7 40 3.0 29.7 2.0 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srh CheR PF01739.16 017000.3_45723001_2 - 0.075 12.4 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Flavodoxin_2 PF02525.15 017000.3_45723001_3 - 2e-51 174.4 0.0 2.7e-51 174.0 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.13 017000.3_45723001_3 - 5.7e-10 39.0 0.0 9.5e-10 38.3 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_4 PF12682.5 017000.3_45723001_3 - 0.0045 16.5 0.1 0.016 14.7 0.1 1.8 1 1 0 1 1 1 1 Flavodoxin IL10 PF00726.15 001009327.1_39523001_1 - 1.7e-105 349.7 0.6 2.3e-105 349.3 0.6 1.2 1 0 0 1 1 1 1 Interleukin 10 IL22 PF14565.4 001009327.1_39523001_1 - 2.5e-05 24.4 0.4 3.6e-05 23.9 0.4 1.2 1 0 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor Carn_acyltransf PF00755.18 001081808.1_21026001_1 - 4.9e-196 652.7 0.0 6e-196 652.4 0.0 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CPT_N PF16484.3 001081808.1_21026001_1 - 1.4e-27 95.3 0.1 2.8e-27 94.3 0.1 1.5 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus tRNA-synt_1b PF00579.23 003680.3_26227001_3 - 1.1e-74 251.3 0.0 1.4e-74 250.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA_bind PF01588.18 003680.3_26227001_3 - 4.7e-33 113.0 0.1 9e-33 112.1 0.1 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain Ribosomal_L5 PF00281.17 001001638.1_49822001_1 - 4.1e-23 81.3 0.0 2.3e-21 75.7 0.0 2.3 2 0 0 2 2 2 1 Ribosomal protein L5 Ribosomal_L5_C PF00673.19 001001638.1_49822001_1 - 1.3e-21 76.4 0.0 2e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus NGF PF00243.16 001012437.1_39722001_1 - 1.6e-51 173.1 2.6 2.8e-51 172.4 2.6 1.3 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.3 001012437.1_39722001_1 - 0.00039 20.7 0.2 0.00058 20.2 0.2 1.2 1 0 0 1 1 1 1 Spaetzle Apolipoprotein PF01442.16 001009007.1_39723001_2 - 1.7e-54 184.6 22.9 1.7e-54 184.6 22.9 1.5 2 0 0 2 2 1 1 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.9 001009007.1_39723001_2 - 9.7e-05 22.4 9.8 0.025 14.5 1.0 2.7 3 0 0 3 3 2 2 Apolipophorin-III precursor (apoLp-III) Baculo_PEP_C PF04513.10 001009007.1_39723001_2 - 0.00079 19.3 6.0 2.2 8.2 0.1 3.2 2 1 1 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus Phage_Mu_Gam PF07352.10 001009007.1_39723001_2 - 0.0012 18.6 10.5 0.21 11.3 1.7 3.1 2 2 1 3 3 3 2 Bacteriophage Mu Gam like protein DUF883 PF05957.11 001009007.1_39723001_2 - 0.0028 18.1 29.5 1.6 9.2 4.9 4.8 1 1 3 4 4 4 3 Bacterial protein of unknown function (DUF883) DIT1_PvcA PF05141.10 001009007.1_39723001_2 - 0.003 16.9 1.1 0.003 16.9 1.1 1.9 2 0 0 2 2 2 1 Pyoverdine/dityrosine biosynthesis protein YtxH PF12732.5 001009007.1_39723001_2 - 0.0096 16.3 15.2 0.07 13.6 1.6 4.7 1 1 2 3 3 3 1 YtxH-like protein LEDGF PF11467.6 001009007.1_39723001_2 - 0.019 14.5 1.0 0.39 10.3 0.2 2.3 2 0 0 2 2 2 0 Lens epithelium-derived growth factor (LEDGF) Prominin PF05478.9 001009007.1_39723001_2 - 0.02 12.8 4.9 0.18 9.6 4.9 1.9 1 1 0 1 1 1 0 Prominin DUF1690 PF07956.9 001009007.1_39723001_2 - 0.029 14.6 13.8 0.17 12.2 6.6 2.8 2 1 1 3 3 3 0 Protein of Unknown function (DUF1690) CHASE6_C PF17150.2 001009007.1_39723001_2 - 0.031 14.8 2.5 1 10.0 0.2 3.1 2 1 1 3 3 3 0 C-terminal domain of two-partite extracellular sensor domain MSP1_C PF07462.9 001009007.1_39723001_2 - 0.053 12.1 0.0 0.11 11.1 0.0 1.4 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Phasin PF05597.9 001009007.1_39723001_2 - 0.083 12.8 15.0 0.4 10.6 2.2 3.2 1 1 1 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF1664 PF07889.10 001009007.1_39723001_2 - 0.1 12.4 9.3 1.5 8.7 0.8 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF1043 PF06295.10 001009007.1_39723001_2 - 0.14 12.0 13.9 0.14 12.0 0.3 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1043) Baculo_p24 PF05073.10 001009007.1_39723001_2 - 0.16 11.6 0.4 3 7.4 0.0 2.2 2 0 0 2 2 2 0 Baculovirus P24 capsid protein Fzo_mitofusin PF04799.11 001009007.1_39723001_2 - 0.18 11.2 13.0 1.7 8.0 4.6 3.1 2 1 1 3 3 3 0 fzo-like conserved region ApoO PF09769.7 001009007.1_39723001_2 - 0.18 11.7 3.2 14 5.6 0.1 3.1 2 1 0 2 2 2 0 Apolipoprotein O DUF948 PF06103.9 001009007.1_39723001_2 - 0.22 11.7 5.7 14 5.9 0.4 3.7 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF4164 PF13747.4 001009007.1_39723001_2 - 0.28 11.3 23.7 0.3 11.2 3.8 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) DUF4795 PF16043.3 001009007.1_39723001_2 - 0.29 10.6 16.5 2.8 7.4 6.8 3.1 2 2 0 2 2 2 0 Domain of unknown function (DUF4795) ApoA-II PF04711.11 001009007.1_39723001_2 - 0.32 11.1 3.6 4.6 7.4 0.3 3.8 3 2 0 3 3 3 0 Apolipoprotein A-II (ApoA-II) Gp-FAR-1 PF05823.10 001009007.1_39723001_2 - 0.33 11.1 2.8 8.5 6.6 0.4 2.3 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) HSBP1 PF06825.10 001009007.1_39723001_2 - 0.34 10.7 4.6 3.1 7.7 0.0 3.4 4 0 0 4 4 2 0 Heat shock factor binding protein 1 DUF1640 PF07798.9 001009007.1_39723001_2 - 0.44 10.4 14.2 2.3 8.1 0.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) Apo-CIII PF05778.10 001009007.1_39723001_2 - 0.5 9.9 4.1 0.22 11.0 0.2 2.4 2 1 0 2 2 2 0 Apolipoprotein CIII (Apo-CIII) Exonuc_VII_L PF02601.13 001009007.1_39723001_2 - 0.57 9.6 18.2 0.51 9.7 3.7 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit TipAS PF07739.11 001009007.1_39723001_2 - 0.63 10.5 16.6 5.8 7.3 0.2 4.2 2 2 2 4 4 4 0 TipAS antibiotic-recognition domain BshC PF10079.7 001009007.1_39723001_2 - 0.63 8.6 12.5 2.3 6.7 0.4 2.6 2 1 0 2 2 2 0 Bacillithiol biosynthesis BshC AAA_13 PF13166.4 001009007.1_39723001_2 - 0.77 8.2 4.1 6.2 5.2 0.3 2.2 2 0 0 2 2 2 0 AAA domain RE_HindIII PF09518.8 001009007.1_39723001_2 - 0.8 8.7 4.7 0.42 9.7 0.7 2.0 2 0 0 2 2 2 0 HindIII restriction endonuclease DUF342 PF03961.11 001009007.1_39723001_2 - 0.9 7.9 6.2 2.9 6.2 0.0 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF342) CREPT PF16566.3 001009007.1_39723001_2 - 1 9.4 12.6 2 8.4 6.9 2.5 2 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour OmpH PF03938.12 001009007.1_39723001_2 - 1.1 9.1 26.0 2.5 7.9 6.6 3.0 1 1 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF1451 PF07295.9 001009007.1_39723001_2 - 1.3 8.9 19.1 0.7 9.8 2.1 3.2 2 1 1 3 3 3 0 Zinc-ribbon containing domain TBPIP PF07106.11 001009007.1_39723001_2 - 1.9 8.1 11.6 12 5.5 0.4 2.8 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Muted PF14942.4 001009007.1_39723001_2 - 2.1 8.5 13.4 1.9 8.7 0.9 3.0 2 1 1 3 3 3 0 Organelle biogenesis, Muted-like protein RRF PF01765.17 001009007.1_39723001_2 - 2.2 8.0 7.7 2.1 8.2 0.3 2.8 2 1 0 2 2 2 0 Ribosome recycling factor Alanine_zipper PF11839.6 001009007.1_39723001_2 - 3.6 7.8 0.0 3.6 7.8 0.0 3.8 4 0 0 4 4 3 0 Alanine-zipper, major outer membrane lipoprotein Nbl1_Borealin_N PF10444.7 001009007.1_39723001_2 - 3.7 7.1 12.8 0.79 9.3 2.0 3.7 3 1 0 3 3 3 0 Nbl1 / Borealin N terminal Atg14 PF10186.7 001009007.1_39723001_2 - 3.9 6.3 14.3 0.28 10.1 0.3 2.3 2 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF16 PF01519.14 001009007.1_39723001_2 - 4.8 7.6 9.1 4.7 7.6 0.7 2.7 2 1 0 2 2 2 0 Protein of unknown function DUF16 Spc7 PF08317.9 001009007.1_39723001_2 - 5.3 5.7 21.5 1.1 8.0 4.1 2.3 1 1 0 2 2 2 0 Spc7 kinetochore protein CorA PF01544.16 001009007.1_39723001_2 - 5.7 6.0 8.2 4.7 6.3 3.6 2.1 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF45 PF01863.15 001009007.1_39723001_2 - 6.6 6.6 12.1 1.3 8.9 1.2 2.8 1 1 1 3 3 3 0 Protein of unknown function DUF45 Noelin-1 PF12308.6 001009007.1_39723001_2 - 8.4 6.3 10.3 53 3.7 0.2 3.3 3 0 0 3 3 3 0 Neurogenesis glycoprotein KxDL PF10241.7 001009007.1_39723001_2 - 8.8 6.6 15.5 15 5.8 0.5 3.6 2 1 1 3 3 3 0 Uncharacterized conserved protein E2F_TDP PF02319.18 001137626.1_45725001_1 - 2.1e-24 85.2 0.3 3.4e-24 84.5 0.3 1.3 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain B-block_TFIIIC PF04182.10 001137626.1_45725001_1 - 0.13 12.3 0.1 0.3 11.1 0.1 1.6 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC E2F_CC-MB PF16421.3 001137626.1_45725001_2 - 1.2e-22 80.0 0.0 2e-22 79.3 0.0 1.3 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain Sprouty PF05210.11 001047089.1_45723001_1 - 1.3e-26 93.0 25.4 3e-26 91.8 23.6 2.2 2 0 0 2 2 2 1 Sprouty protein (Spry) WH1 PF00568.21 001047089.1_45723001_1 - 4e-11 42.7 0.0 7e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 WH1 domain Casein PF00363.16 001082401.1_37922001_3 - 5.5e-13 49.3 19.2 1.6e-11 44.6 6.3 2.3 1 1 1 2 2 2 2 Casein Globin PF00042.20 001135831.1_39721001_1 - 1e-31 109.6 0.0 3.8e-31 107.8 0.0 1.7 2 0 0 2 2 2 1 Globin Carn_acyltransf PF00755.18 001007191.1_49825001_1 - 3e-191 636.9 0.0 3.5e-191 636.7 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CPT_N PF16484.3 001007191.1_49825001_1 - 1.4e-26 92.0 0.1 3e-26 91.0 0.1 1.6 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus DUF3128 PF11326.6 001007191.1_49825001_1 - 0.016 15.4 0.1 0.39 10.9 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3128) Ribosomal_L29 PF00831.21 214326.2_49821001_1 - 2.4e-20 72.1 2.9 2.4e-20 72.1 2.9 2.4 2 1 0 2 2 2 1 Ribosomal L29 protein ABM PF03992.14 001098724.1_45724001_1 - 2.4e-08 33.8 0.4 6.2e-08 32.5 0.4 1.8 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase EF-hand_5 PF13202.4 001098724.1_45724001_1 - 3.9e-08 32.3 2.5 8.3e-07 28.1 1.3 2.4 1 1 1 2 2 2 1 EF hand EF-hand_1 PF00036.30 001098724.1_45724001_1 - 3.6e-07 29.1 1.2 5.8e-06 25.4 0.9 2.3 1 1 1 2 2 2 1 EF hand EF-hand_7 PF13499.4 001098724.1_45724001_1 - 1.7e-05 25.1 1.3 0.00027 21.2 0.2 2.4 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.4 001098724.1_45724001_1 - 1.9e-05 24.1 1.6 0.00026 20.6 1.5 2.4 1 1 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.4 001098724.1_45724001_1 - 0.00011 21.8 0.7 0.00055 19.5 0.4 2.1 1 1 1 2 2 2 1 EF-hand domain pair MukF_M PF17192.2 001098724.1_45724001_1 - 0.046 13.3 0.4 0.11 12.2 0.4 1.6 1 0 0 1 1 1 0 MukF middle domain Cactin_mid PF10312.7 001098724.1_45724001_1 - 0.046 13.3 0.2 0.077 12.6 0.2 1.3 1 0 0 1 1 1 0 Conserved mid region of cactin YlqD PF11068.6 001098724.1_45724001_1 - 0.22 11.8 1.5 0.31 11.3 0.8 1.6 1 1 1 2 2 2 0 YlqD protein Dmrt1 PF12374.6 214111.1_49825001_3 - 1.3e-32 111.9 4.7 1.3e-32 111.9 4.7 2.6 2 0 0 2 2 2 1 Double-sex mab3 related transcription factor 1 DM PF00751.16 214111.1_49825001_3 - 2.2e-21 75.4 10.7 2.2e-21 75.4 10.7 2.0 2 0 0 2 2 2 1 DM DNA binding domain BAH PF01426.16 022588.1_45726001_1 - 3.2e-35 120.5 0.0 1.4e-34 118.4 0.0 2.0 1 1 0 1 1 1 1 BAH domain ELM2 PF01448.22 022588.1_45726001_1 - 2.7e-14 53.5 0.3 1.2e-13 51.5 0.0 2.2 2 0 0 2 2 2 1 ELM2 domain GATA PF00320.25 022588.1_45726001_1 - 2.3e-09 36.6 10.0 5.4e-09 35.4 10.0 1.7 1 0 0 1 1 1 1 GATA zinc finger Myb_DNA-binding PF00249.29 022588.1_45726001_1 - 9.8e-06 25.5 0.1 2.8e-05 24.0 0.1 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.3 022588.1_45726001_1 - 0.0071 16.1 0.2 0.02 14.6 0.2 1.7 1 0 0 1 1 1 1 Myb DNA-binding like Kelch_1 PF01344.23 001114671.1_49826001_3 - 1.2e-86 283.9 14.8 5e-17 61.1 0.1 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 001114671.1_49826001_3 - 2.3e-51 170.3 6.4 8.1e-11 41.7 0.1 6.5 2 2 4 6 6 6 6 Kelch motif BACK PF07707.13 001114671.1_49826001_3 - 3.2e-33 113.8 0.9 7.6e-33 112.6 0.9 1.7 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.4 001114671.1_49826001_3 - 2.5e-31 107.2 19.8 2.1e-07 30.9 0.4 6.7 7 0 0 7 7 7 6 Galactose oxidase, central domain BTB PF00651.29 001114671.1_49826001_3 - 4.6e-30 104.0 0.2 7.7e-30 103.2 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_2 PF07646.13 001114671.1_49826001_3 - 5.7e-29 98.8 3.3 3.2e-07 29.9 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.4 001114671.1_49826001_3 - 4.8e-22 77.5 6.8 0.00044 20.0 0.1 6.3 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.4 001114671.1_49826001_3 - 0.0015 18.4 16.5 0.84 9.6 0.1 6.3 7 0 0 7 7 7 2 Kelch motif Ion_trans PF00520.29 013178.1_45729001_3 - 1.5e-252 833.1 103.1 9.5e-81 270.5 14.8 4.1 4 0 0 4 4 4 4 Ion transport protein Na_trans_assoc PF06512.11 013178.1_45729001_3 - 3.8e-56 190.2 0.0 3.8e-56 190.2 0.0 2.3 2 0 0 2 2 2 1 Sodium ion transport-associated PKD_channel PF08016.10 013178.1_45729001_3 - 4.8e-06 25.4 82.1 0.00024 19.8 0.2 9.4 7 3 3 10 10 10 7 Polycystin cation channel GPHH PF16905.3 013178.1_45729001_3 - 2e-05 24.2 0.0 4.9e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated IQ PF00612.25 013178.1_45729001_3 - 0.24 11.1 7.3 0.019 14.6 1.0 2.4 2 0 0 2 2 2 0 IQ calmodulin-binding motif Lustrin_cystein PF14625.4 013178.1_45729001_3 - 1.1 9.5 5.9 0.25 11.7 0.3 2.6 2 0 0 2 2 2 0 Lustrin, cysteine-rich repeated domain Hormone_2 PF00123.18 001009776.1_39526001_1 - 8e-24 83.2 2.4 2e-11 43.5 0.2 2.4 2 0 0 2 2 2 2 Peptide hormone Herpes_LMP1 PF05297.9 001009776.1_39526001_1 - 0.16 11.0 1.6 0.31 10.1 1.6 1.4 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Homeobox PF00046.27 017149.1_45725001_2 - 2.5e-22 78.3 7.5 5.6e-22 77.2 7.5 1.6 1 0 0 1 1 1 1 Homeobox domain Macoilin PF09726.7 017149.1_45725001_2 - 0.22 9.9 5.9 0.36 9.2 5.9 1.3 1 0 0 1 1 1 0 Transmembrane protein SelP_N PF04592.12 017149.1_45725001_2 - 0.57 9.4 17.7 1.4 8.1 17.7 1.6 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Arf PF00025.19 001007739.1_45726001_2 - 2.3e-62 209.4 0.0 3.1e-62 209.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001007739.1_45726001_2 - 6.3e-09 35.4 0.0 8.9e-09 34.9 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 001007739.1_45726001_2 - 2.5e-07 30.8 0.0 4.4e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.18 001007739.1_45726001_2 - 4.9e-07 29.1 0.1 2.2e-05 23.7 0.0 2.1 1 1 1 2 2 2 1 G-protein alpha subunit Ras PF00071.20 001007739.1_45726001_2 - 2.1e-06 27.3 0.0 3.2e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.21 001007739.1_45726001_2 - 7.1e-05 22.7 0.0 0.00011 22.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001007739.1_45726001_2 - 0.0044 16.4 0.0 0.019 14.4 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Ion_trans PF00520.29 001082722.1_37924001_2 - 7.1e-51 172.7 11.0 9.9e-51 172.2 11.0 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001082722.1_37924001_2 - 2.2e-28 98.3 0.0 4.4e-28 97.4 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 001082722.1_37924001_2 - 2.7e-14 52.8 4.3 2.7e-14 52.8 4.3 2.5 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.10 001082722.1_37924001_2 - 0.073 11.6 3.9 0.025 13.1 0.8 1.7 1 1 1 2 2 2 0 Polycystin cation channel HCO3_cotransp PF00955.19 178092.2_45728001_2 - 2.1e-247 821.9 6.2 2.6e-247 821.6 6.2 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 178092.2_45728001_2 - 7.2e-106 353.7 0.0 1.2e-105 353.0 0.0 1.4 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Cyclin_N PF00134.21 053662.3_45725001_3 - 3.1e-15 55.9 0.1 1e-09 38.1 0.0 2.5 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.17 053662.3_45725001_3 - 2e-05 24.6 0.3 7.6e-05 22.6 0.0 2.1 2 0 0 2 2 2 1 Cyclin, C-terminal domain TFIIB PF00382.17 053662.3_45725001_3 - 0.0022 17.9 1.8 0.43 10.5 0.0 2.9 3 0 0 3 3 3 2 Transcription factor TFIIB repeat Cyclin_C_2 PF16899.3 053662.3_45725001_3 - 0.0061 16.8 0.0 0.015 15.6 0.0 1.6 1 0 0 1 1 1 1 Cyclin C-terminal domain DUF936 PF06075.10 053662.3_45725001_3 - 3.2 6.5 29.9 4.2 6.1 29.9 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Sushi PF00084.18 001081855.2_21024001_2 - 3.7e-51 171.4 71.2 1.3e-09 38.4 2.9 7.5 6 1 1 7 7 7 6 Sushi repeat (SCR repeat) Lectin_C PF00059.19 001081855.2_21024001_2 - 5.5e-25 88.1 5.6 5.5e-25 88.1 5.6 2.5 2 0 0 2 2 2 1 Lectin C-type domain EGF PF00008.25 001081855.2_21024001_2 - 3.9e-06 26.9 15.7 7.8e-06 25.9 10.2 4.4 3 0 0 3 3 3 1 EGF-like domain hEGF PF12661.5 001081855.2_21024001_2 - 0.00042 20.7 7.2 0.00042 20.7 7.2 4.5 4 0 0 4 4 4 1 Human growth factor-like EGF EGF_2 PF07974.11 001081855.2_21024001_2 - 0.0065 16.7 11.0 0.0065 16.7 11.0 4.3 2 0 0 2 2 2 1 EGF-like domain SAM_decarbox PF01536.14 001081855.2_21024001_2 - 0.062 12.1 0.1 0.094 11.6 0.1 1.2 1 0 0 1 1 1 0 Adenosylmethionine decarboxylase Plasmod_Pvs28 PF06247.9 001081855.2_21024001_2 - 2.3 8.4 18.9 0.033 14.4 6.5 4.4 3 2 0 3 3 3 0 Pvs28 EGF domain Nramp PF01566.16 213821.2_49825001_2 - 2.5e-116 388.4 15.0 3.8e-116 387.9 15.0 1.3 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein IRK PF01007.18 170718.1_45726001_2 - 1.6e-143 477.5 0.0 2e-143 477.2 0.0 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 170718.1_45726001_2 - 0.0043 16.9 0.4 0.0075 16.1 0.4 1.4 1 0 0 1 1 1 1 Ion channel PFK PF00365.18 001044550.1_49826001_1 - 2.4e-199 660.1 8.8 6.4e-109 363.5 1.8 2.2 2 0 0 2 2 2 2 Phosphofructokinase Connexin PF00029.17 001044550.1_49826001_1 - 0.41 10.2 3.4 0.67 9.6 3.4 1.3 1 0 0 1 1 1 0 Connexin LRR_6 PF13516.4 001009060.1_39723001_1 - 1.5e-36 121.2 31.5 2.5e-05 23.8 0.6 12.1 13 0 0 13 13 13 10 Leucine Rich repeat LRR_4 PF12799.5 001009060.1_39723001_1 - 1.4e-14 53.7 14.6 0.04 14.2 1.0 8.5 7 3 0 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001009060.1_39723001_1 - 1e-06 28.2 12.6 1.3 8.7 0.2 7.6 8 0 0 8 8 8 3 Leucine rich repeat LRR_1 PF00560.31 001009060.1_39723001_1 - 0.0022 18.1 35.0 0.26 11.8 0.2 11.3 12 1 1 13 13 13 1 Leucine Rich Repeat Dynein_heavy PF03028.13 001376.4_26229001_3 - 2.9e-170 567.8 0.3 2.9e-170 567.8 0.3 2.4 3 0 0 3 3 2 1 Dynein heavy chain and region D6 of dynein motor DHC_N1 PF08385.10 001376.4_26229001_3 - 6.5e-134 447.5 12.4 6.5e-134 447.5 12.4 4.5 5 1 1 6 6 5 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.11 001376.4_26229001_3 - 1.3e-114 383.3 15.0 1.3e-114 383.3 15.0 5.5 5 1 0 5 5 4 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.5 001376.4_26229001_3 - 2.2e-79 266.3 0.0 7.8e-79 264.5 0.0 2.0 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.5 001376.4_26229001_3 - 1.1e-71 240.4 0.0 1.1e-71 240.4 0.0 4.0 5 0 0 5 5 4 1 ATP-binding dynein motor region D5 AAA_8 PF12780.5 001376.4_26229001_3 - 1.2e-44 152.3 0.0 9e-44 149.5 0.0 2.3 1 1 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.5 001376.4_26229001_3 - 3.1e-42 144.7 15.7 3.1e-42 144.7 15.7 2.2 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.12 001376.4_26229001_3 - 8e-30 103.5 0.0 3.6e-12 46.3 0.0 5.9 5 1 0 5 5 4 3 AAA domain (dynein-related subfamily) AAA_7 PF12775.5 001376.4_26229001_3 - 1.2e-21 77.2 0.0 3.8e-21 75.4 0.0 1.9 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA PF00004.27 001376.4_26229001_3 - 1.5e-12 47.9 0.0 0.048 13.9 0.0 5.3 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 001376.4_26229001_3 - 2.9e-12 46.9 11.5 0.013 15.6 0.0 7.8 8 0 0 8 8 7 4 AAA domain AAA_33 PF13671.4 001376.4_26229001_3 - 3.3e-11 43.4 0.1 0.033 14.2 0.0 5.8 5 0 0 5 5 4 3 AAA domain AAA_16 PF13191.4 001376.4_26229001_3 - 4.6e-10 40.0 0.0 2.5 8.3 0.0 6.9 6 0 0 6 6 6 2 AAA ATPase domain AAA_18 PF13238.4 001376.4_26229001_3 - 2.8e-09 37.5 3.3 0.068 13.6 0.0 6.5 6 0 0 6 6 5 1 AAA domain Mg_chelatase PF01078.19 001376.4_26229001_3 - 9.2e-07 28.3 0.5 0.13 11.5 0.0 3.9 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_30 PF13604.4 001376.4_26229001_3 - 3.4e-05 23.5 0.4 10 5.7 0.0 4.6 4 0 0 4 4 4 0 AAA domain IstB_IS21 PF01695.15 001376.4_26229001_3 - 0.00011 21.8 0.4 0.14 11.8 0.0 4.4 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_29 PF13555.4 001376.4_26229001_3 - 0.00017 21.1 0.0 2.3 7.9 0.0 3.6 3 0 0 3 3 3 1 P-loop containing region of AAA domain T2SSE PF00437.18 001376.4_26229001_3 - 0.00023 20.2 0.0 0.16 10.9 0.0 3.6 3 0 0 3 3 3 1 Type II/IV secretion system protein ABC_tran PF00005.25 001376.4_26229001_3 - 0.00024 21.5 3.5 3.8 7.9 0.0 5.2 4 0 0 4 4 3 2 ABC transporter AAA_19 PF13245.4 001376.4_26229001_3 - 0.00067 19.9 0.9 0.23 11.7 0.0 4.5 4 0 0 4 4 4 1 AAA domain AAA_24 PF13479.4 001376.4_26229001_3 - 0.001 18.7 0.2 28 4.2 0.0 4.9 4 0 0 4 4 4 0 AAA domain ERM PF00769.17 001376.4_26229001_3 - 0.002 17.9 6.3 0.002 17.9 6.3 4.2 5 0 0 5 5 3 2 Ezrin/radixin/moesin family FtsK_SpoIIIE PF01580.16 001376.4_26229001_3 - 0.003 16.8 0.0 3.6 6.7 0.0 3.8 3 0 0 3 3 3 1 FtsK/SpoIIIE family RNA_helicase PF00910.20 001376.4_26229001_3 - 0.0032 17.7 0.0 14 6.0 0.0 4.9 4 0 0 4 4 4 0 RNA helicase AAA_25 PF13481.4 001376.4_26229001_3 - 0.017 14.5 0.1 0.45 9.9 0.0 3.2 3 0 0 3 3 3 0 AAA domain TsaE PF02367.15 001376.4_26229001_3 - 0.23 11.3 1.5 12 5.8 0.0 3.9 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Phlebovirus_NSM PF07246.9 001376.4_26229001_3 - 5.6 6.1 18.9 0.0028 16.9 2.3 2.7 2 0 0 2 2 1 0 Phlebovirus nonstructural protein NS-M Serum_albumin PF00273.18 001009376.1_39525001_3 - 1.9e-158 522.7 45.7 3.3e-59 199.5 11.5 3.1 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.8 001009376.1_39525001_3 - 0.00013 21.8 17.0 0.021 14.6 0.2 5.9 6 0 0 6 6 6 3 Vitamin D binding protein, domain III CFTR_R PF14396.4 001110510.1_21029001_2 - 7.8e-104 345.7 5.3 1.2e-103 345.0 5.3 1.3 1 0 0 1 1 1 1 Cystic fibrosis TM conductance regulator (CFTR), regulator domain ABC_membrane PF00664.21 001110510.1_21029001_2 - 8.4e-92 307.6 39.6 3.4e-50 171.1 17.9 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001110510.1_21029001_2 - 4.2e-59 198.8 0.0 5.3e-33 114.3 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.4 001110510.1_21029001_2 - 1.3e-07 31.6 1.6 0.017 14.8 0.0 3.5 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.17 001110510.1_21029001_2 - 3.4e-07 29.8 0.0 0.006 15.9 0.0 3.4 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.4 001110510.1_21029001_2 - 3.1e-06 26.7 0.7 0.00096 18.7 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain T2SSE PF00437.18 001110510.1_21029001_2 - 9.2e-06 24.8 0.2 0.038 12.9 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein DUF258 PF03193.14 001110510.1_21029001_2 - 3.3e-05 23.7 0.4 0.045 13.5 0.1 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.4 001110510.1_21029001_2 - 0.00015 22.1 0.0 0.37 11.0 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.15 001110510.1_21029001_2 - 0.00019 21.4 0.8 0.083 12.8 0.1 2.8 2 0 0 2 2 2 1 Domain of unknown function DUF87 ArgK PF03308.14 001110510.1_21029001_2 - 0.0013 17.6 0.8 0.016 14.0 0.1 2.3 2 0 0 2 2 2 1 ArgK protein Zeta_toxin PF06414.10 001110510.1_21029001_2 - 0.0015 17.7 0.6 0.21 10.7 0.1 2.4 2 0 0 2 2 2 1 Zeta toxin MMR_HSR1 PF01926.21 001110510.1_21029001_2 - 0.0016 18.4 0.0 0.32 10.9 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.10 001110510.1_21029001_2 - 0.0017 18.1 0.9 1.9 8.2 0.1 2.7 2 0 0 2 2 2 2 NACHT domain AAA_22 PF13401.4 001110510.1_21029001_2 - 0.0046 17.1 0.4 3.7 7.7 0.0 2.9 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.13 001110510.1_21029001_2 - 0.012 15.4 0.4 0.38 10.5 0.0 2.6 3 0 0 3 3 2 0 NTPase Roc PF08477.11 001110510.1_21029001_2 - 0.014 15.5 0.2 4.8 7.3 0.0 3.4 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.4 001110510.1_21029001_2 - 0.031 13.9 0.0 1.1 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain TsaE PF02367.15 001110510.1_21029001_2 - 0.05 13.5 0.6 13 5.7 0.1 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MobB PF03205.12 001110510.1_21029001_2 - 0.056 13.2 1.8 16 5.3 0.1 3.4 4 0 0 4 4 4 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.4 001110510.1_21029001_2 - 0.057 13.6 0.1 19 5.4 0.0 2.9 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.20 001110510.1_21029001_2 - 0.057 12.3 0.1 1.5 7.6 0.0 2.7 2 0 0 2 2 2 0 NB-ARC domain FtsK_SpoIIIE PF01580.16 001110510.1_21029001_2 - 0.092 12.0 0.9 6.1 6.0 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family Biotin_lipoyl_2 PF13533.4 001110510.1_21029001_2 - 0.098 12.4 0.1 0.21 11.3 0.1 1.5 1 0 0 1 1 1 0 Biotin-lipoyl like cobW PF02492.17 001110510.1_21029001_2 - 0.1 12.0 1.8 5.9 6.3 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Rotamase_2 PF13145.4 001110510.1_21029001_2 - 0.18 12.6 0.0 0.47 11.2 0.0 1.6 1 0 0 1 1 1 0 PPIC-type PPIASE domain AAA_23 PF13476.4 001110510.1_21029001_2 - 1.2 9.5 15.0 1.2 9.5 0.1 4.1 4 0 0 4 4 4 0 AAA domain Sushi PF00084.18 001082312.1_37925001_1 - 7.1e-37 125.7 63.4 7.2e-09 36.0 4.5 6.6 6 1 1 7 7 7 5 Sushi repeat (SCR repeat) Lectin_C PF00059.19 001082312.1_37925001_1 - 8.6e-24 84.2 3.0 8.6e-24 84.2 3.0 2.5 2 1 1 3 3 3 1 Lectin C-type domain EGF PF00008.25 001082312.1_37925001_1 - 2.7e-05 24.2 7.3 2.7e-05 24.2 7.3 3.8 3 0 0 3 3 3 1 EGF-like domain EGF_2 PF07974.11 001082312.1_37925001_1 - 0.0011 19.2 13.0 0.0015 18.7 8.4 4.0 2 0 0 2 2 2 1 EGF-like domain AsmA PF05170.12 001082312.1_37925001_1 - 0.02 13.6 0.0 0.028 13.1 0.0 1.1 1 0 0 1 1 1 0 AsmA family hEGF PF12661.5 001082312.1_37925001_1 - 0.2 12.2 12.2 0.071 13.7 5.8 3.8 2 0 0 2 2 2 0 Human growth factor-like EGF Plasmod_Pvs28 PF06247.9 001082312.1_37925001_1 - 0.22 11.7 12.0 0.13 12.5 8.0 3.0 2 0 0 2 2 2 0 Pvs28 EGF domain HCO3_cotransp PF00955.19 001081162.1_32927001_2 - 4.9e-148 494.1 3.7 7e-148 493.5 3.7 1.1 1 0 0 1 1 1 1 HCO3- transporter family PTS_EIIA_2 PF00359.20 001081162.1_32927001_2 - 0.00015 21.6 0.1 0.00077 19.2 0.0 2.1 2 0 0 2 2 2 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Band_3_cyto PF07565.11 001081162.1_32927001_2 - 0.002 17.9 0.0 0.0035 17.1 0.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Globin PF00042.20 033234.1_45722001_3 - 9.2e-31 106.5 0.0 1.5e-30 105.8 0.0 1.3 1 0 0 1 1 1 1 Globin Interferon PF00143.17 008333.2_32922001_2 - 1.4e-58 197.5 0.4 1.6e-58 197.3 0.4 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Ribosomal_S3_C PF00189.18 001044601.1_49822001_2 - 2.9e-23 82.0 0.3 9.4e-23 80.4 0.2 1.8 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.15 001044601.1_49822001_2 - 2e-11 43.4 0.1 3.2e-11 42.8 0.1 1.3 1 0 0 1 1 1 1 KH domain Cadherin PF00028.15 053572.1_45729001_3 - 5.5e-74 244.6 0.8 5.9e-15 55.3 0.0 6.6 6 0 0 6 6 6 6 Cadherin domain Defensin_beta PF00711.17 001129750.1_39721001_1 - 8.5e-11 41.6 10.8 1e-10 41.3 10.8 1.1 1 0 0 1 1 1 1 Beta defensin Serum_albumin PF00273.18 001005208.1_49825001_1 - 1.9e-155 512.9 43.8 1e-58 197.9 11.1 3.0 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.8 001005208.1_49825001_1 - 0.0001 22.1 21.4 0.4 10.6 0.1 6.7 6 0 0 6 6 6 3 Vitamin D binding protein, domain III Lipocalin PF00061.21 213814.2_49822001_2 - 7.5e-30 103.9 0.2 9.6e-30 103.5 0.2 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Pkinase PF00069.23 001014254.1_45725001_1 - 1e-49 169.1 0.1 1.3e-49 168.8 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001014254.1_45725001_1 - 4.9e-20 71.8 0.0 1e-19 70.7 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pou PF00157.15 214264.1_49825001_1 - 2.9e-38 129.6 0.2 7.1e-38 128.3 0.2 1.7 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 214264.1_49825001_1 - 2e-17 62.6 3.5 5.1e-17 61.3 3.5 1.8 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 214264.1_49825001_1 - 0.028 14.2 0.2 0.085 12.6 0.2 1.8 1 0 0 1 1 1 0 Homeobox KN domain Insulin PF00049.16 213970.1_49822001_3 - 6.9e-05 23.6 5.7 0.0012 19.6 5.7 2.1 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 213970.1_49822001_3 - 0.0052 16.6 1.8 1.4 8.8 0.4 2.3 2 0 0 2 2 2 2 Nematode insulin-related peptide beta type UcrQ PF02939.14 001025134.1_45723001_2 - 4.5e-31 106.5 0.2 6.7e-31 105.9 0.2 1.3 1 0 0 1 1 1 1 UcrQ family SPC12 PF06645.11 001114288.2_49822001_3 - 8.2e-30 102.6 1.8 1.5e-29 101.7 1.8 1.4 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF1440 PF07274.10 001114288.2_49822001_3 - 0.029 14.6 0.0 0.053 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1440) PKD_channel PF08016.10 001105903.1_45725001_2 - 5.1e-10 38.5 13.0 7.7e-10 37.9 13.0 1.2 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.29 001105903.1_45725001_2 - 0.017 14.2 21.3 0.051 12.7 21.4 1.6 1 1 0 1 1 1 0 Ion transport protein DUF1866 PF08952.9 001105903.1_45725001_2 - 0.12 12.1 0.5 1.8 8.3 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1866) Pkinase_Tyr PF07714.15 001042607.1_32927001_2 - 4.4e-81 271.8 0.0 6.1e-81 271.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase WIF PF02019.16 001042607.1_32927001_2 - 9e-45 151.4 0.1 1.5e-44 150.7 0.1 1.4 1 0 0 1 1 1 1 WIF domain Pkinase PF00069.23 001042607.1_32927001_2 - 2.1e-27 96.0 0.0 3.3e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Lipocalin PF00061.21 001009366.1_39522001_1 - 1.6e-37 128.8 0.0 1.9e-37 128.5 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Ion_trans PF00520.29 001082707.1_37928001_2 - 3.9e-23 81.8 15.7 5.3e-23 81.4 15.7 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_N PF08412.8 001082707.1_37928001_2 - 4e-20 71.0 0.1 7.7e-20 70.1 0.1 1.5 1 0 0 1 1 1 1 Ion transport protein N-terminal cNMP_binding PF00027.27 001082707.1_37928001_2 - 4.5e-18 64.9 0.0 8.7e-18 64.0 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.14 001082707.1_37928001_2 - 0.0046 16.8 0.2 0.0094 15.8 0.2 1.5 1 0 0 1 1 1 1 Ion channel Ras PF00071.20 001123173.1_49822001_1 - 9e-65 217.1 0.9 1e-64 216.9 0.9 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001123173.1_49822001_1 - 2e-35 121.5 0.8 3.1e-35 120.9 0.1 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001123173.1_49822001_1 - 2.1e-16 59.7 0.2 2.6e-16 59.4 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001123173.1_49822001_1 - 2.5e-06 27.4 0.1 9e-06 25.6 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.14 001123173.1_49822001_1 - 3e-06 27.1 0.7 0.042 13.6 0.2 2.3 1 1 1 2 2 2 2 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 001123173.1_49822001_1 - 6.1e-05 22.3 0.1 7.2e-05 22.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001123173.1_49822001_1 - 7.5e-05 22.1 0.1 0.00011 21.6 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.27 001123173.1_49822001_1 - 0.0032 17.7 0.1 0.4 11.0 0.0 2.4 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.16 001123173.1_49822001_1 - 0.0037 16.7 0.1 0.015 14.7 0.1 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.25 001123173.1_49822001_1 - 0.0067 15.9 0.5 0.017 14.6 0.2 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.25 001123173.1_49822001_1 - 0.012 16.0 0.1 0.04 14.3 0.1 1.8 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.4 001123173.1_49822001_1 - 0.033 14.4 0.0 0.045 14.0 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 001123173.1_49822001_1 - 0.045 13.9 0.0 0.065 13.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.7 001123173.1_49822001_1 - 0.05 13.2 0.1 0.88 9.2 0.0 2.2 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.4 001123173.1_49822001_1 - 0.063 12.9 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.12 001123173.1_49822001_1 - 0.069 13.0 0.0 0.18 11.7 0.0 1.7 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Septin PF00735.16 001123173.1_49822001_1 - 0.071 12.2 0.2 0.19 10.8 0.0 1.7 1 1 0 1 1 1 0 Septin Myotub-related PF06602.12 001107312.1_45726001_2 - 2e-142 474.1 0.2 2.5e-142 473.7 0.2 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.18 001107312.1_45726001_2 - 0.002 17.8 0.0 0.0041 16.8 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 001107312.1_45726001_2 - 0.0057 16.1 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 001107312.1_45726001_2 - 0.14 12.0 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family STAT_bind PF02864.13 001044580.1_49825001_2 - 3.9e-77 259.4 0.0 3.9e-77 259.4 0.0 2.1 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 001044580.1_49825001_2 - 3.6e-56 189.7 18.5 7.2e-56 188.7 18.5 1.5 1 0 0 1 1 1 1 STAT protein, all-alpha domain STAT_int PF02865.15 001044580.1_49825001_2 - 9.2e-38 129.3 7.9 9.2e-38 129.3 7.9 3.3 3 1 1 4 4 3 1 STAT protein, protein interaction domain SH2 PF00017.22 001044580.1_49825001_2 - 1.6e-13 50.4 0.0 4.3e-13 49.0 0.0 1.8 1 0 0 1 1 1 1 SH2 domain E2R135 PF11570.6 001044580.1_49825001_2 - 0.11 12.7 1.3 0.2 11.8 1.3 1.4 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 YojJ PF10372.7 001044580.1_49825001_2 - 0.27 11.2 7.1 1.2 9.1 0.4 2.8 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Fib_alpha PF08702.8 001044580.1_49825001_2 - 0.81 9.7 12.7 0.71 9.9 7.7 2.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.10 001044580.1_49825001_2 - 1.5 8.8 5.7 1.3 8.9 3.7 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus RecG_N PF17190.2 001044580.1_49825001_2 - 1.7 9.3 10.8 2.1 9.0 0.2 3.8 3 1 0 3 3 3 0 RecG N-terminal helical domain DUF1664 PF07889.10 001044580.1_49825001_2 - 2.5 8.0 8.4 6.6 6.6 0.8 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Tropomyosin_1 PF12718.5 001044580.1_49825001_2 - 2.9 7.9 11.7 0.54 10.2 7.0 2.0 2 0 0 2 2 2 0 Tropomyosin like Syntaxin-6_N PF09177.9 001044580.1_49825001_2 - 4.1 7.9 11.0 0.099 13.1 0.6 3.0 3 1 1 4 4 3 0 Syntaxin 6, N-terminal MerR-DNA-bind PF09278.9 001044580.1_49825001_2 - 4.7 7.7 14.8 3.3 8.2 0.6 3.9 4 0 0 4 4 4 0 MerR, DNA binding DUF2408 PF10303.7 001044580.1_49825001_2 - 4.8 7.6 7.8 4.2 7.8 1.2 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF2408) eIF3_N PF09440.8 001044580.1_49825001_2 - 7.2 6.9 13.0 2.4 8.4 2.7 3.1 2 1 1 3 3 3 0 eIF3 subunit 6 N terminal domain DUF342 PF03961.11 001044580.1_49825001_2 - 7.9 4.8 9.0 0.54 8.7 3.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF342) YTH PF04146.13 001047099.1_45726001_3 - 4.5e-40 136.0 0.0 6.5e-40 135.5 0.0 1.2 1 0 0 1 1 1 1 YT521-B-like domain EOS1 PF12326.6 001287685.1_29522001_1 - 0.16 11.8 1.2 0.15 11.9 1.2 1.1 1 0 0 1 1 1 0 N-glycosylation protein Presenilin PF01080.15 001287685.1_29522001_1 - 0.17 10.5 3.2 0.18 10.4 3.2 1.1 1 0 0 1 1 1 0 Presenilin SRP-alpha_N PF04086.11 001287685.1_29522001_1 - 0.65 9.7 20.1 0.84 9.4 20.1 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Connexin PF00029.17 001287685.1_29522001_1 - 3.9 7.1 10.4 5.3 6.6 10.4 1.2 1 0 0 1 1 1 0 Connexin Afi1 PF07792.10 001287685.1_29522001_1 - 3.9 7.8 9.0 0.49 10.7 4.9 1.6 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4758 PF15950.3 001287685.1_29522001_2 - 0.24 11.6 0.1 0.24 11.6 0.1 2.0 2 0 0 2 2 2 0 Putative sperm flagellar membrane protein Tubulin PF00091.23 001283342.1_29524001_1 - 1.4e-67 227.6 0.0 2.2e-67 227.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001283342.1_29524001_1 - 3.3e-42 143.6 0.1 5.1e-42 143.0 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 001283342.1_29524001_1 - 1.4e-05 25.2 0.0 3.3e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.4 001283342.1_29524001_1 - 0.019 14.0 0.0 0.038 13.0 0.0 1.4 1 0 0 1 1 1 0 Tubulin like Tubulin_3 PF14881.4 001283342.1_29524001_1 - 0.031 13.8 0.0 0.058 12.9 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain IRK PF01007.18 001172974.1_09926001_3 - 2.4e-135 450.6 0.1 3.1e-135 450.3 0.1 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel EI24 PF07264.9 001172974.1_09926001_3 - 0.18 11.9 4.9 0.37 10.9 4.9 1.4 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Ion_trans_2 PF07885.14 001172974.1_09926001_3 - 0.32 10.9 4.6 0.63 9.9 4.6 1.5 1 0 0 1 1 1 0 Ion channel Serum_albumin PF00273.18 001133634.2_43525001_3 - 1.4e-159 526.3 56.4 6.4e-60 201.8 11.6 3.1 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.8 001133634.2_43525001_3 - 4.5e-06 26.4 29.1 0.019 14.8 0.3 7.0 7 0 0 7 7 7 3 Vitamin D binding protein, domain III Peptidase_M75 PF09375.8 001133634.2_43525001_3 - 0.21 10.9 0.4 0.39 10.0 0.4 1.4 1 0 0 1 1 1 0 Imelysin DUF4144 PF13642.4 001133634.2_43525001_3 - 0.24 11.9 2.6 5.4 7.5 0.2 3.4 3 0 0 3 3 3 0 protein structure with unknown function bZIP_2 PF07716.13 001287577.1_45726001_2 - 2e-15 56.5 15.2 2e-15 56.5 15.2 1.6 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.19 001287577.1_45726001_2 - 7.3e-05 22.7 7.1 0.00014 21.8 7.1 1.4 1 0 0 1 1 1 1 bZIP transcription factor Taxilin PF09728.7 001287577.1_45726001_2 - 0.019 14.1 1.7 0.025 13.7 1.7 1.1 1 0 0 1 1 1 0 Myosin-like coiled-coil protein bZIP_Maf PF03131.15 001287577.1_45726001_2 - 0.046 14.1 6.4 0.081 13.3 6.4 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor Lipoprotein_20 PF13942.4 001287577.1_45726001_2 - 0.05 13.4 3.7 0.088 12.6 3.7 1.3 1 0 0 1 1 1 0 YfhG lipoprotein TolA_bind_tri PF16331.3 001287577.1_45726001_2 - 0.064 13.2 1.7 0.11 12.4 1.7 1.3 1 0 0 1 1 1 0 TolA binding protein trimerisation Hema_stalk PF08720.8 001287577.1_45726001_2 - 0.18 11.3 0.3 0.29 10.7 0.3 1.2 1 0 0 1 1 1 0 Influenza C hemagglutinin stalk Nup54 PF13874.4 001287577.1_45726001_2 - 0.26 11.2 3.6 0.42 10.6 3.6 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 DivIC PF04977.13 001287577.1_45726001_2 - 0.28 10.9 1.5 0.59 9.8 1.5 1.4 1 0 0 1 1 1 0 Septum formation initiator IRK PF01007.18 001172975.1_09929001_3 - 4.5e-155 515.4 1.7 6e-155 515.0 1.7 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel IRK_N PF08466.8 001172975.1_09929001_3 - 7.7e-26 89.9 1.3 1.3e-25 89.1 1.3 1.4 1 0 0 1 1 1 1 Inward rectifier potassium channel N-terminal Ion_trans_2 PF07885.14 001172975.1_09929001_3 - 0.00034 20.4 5.2 0.00074 19.3 5.2 1.6 1 0 0 1 1 1 1 Ion channel Pkinase PF00069.23 001281572.1_31325001_1 - 1.1e-70 237.9 0.0 4e-70 236.1 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 001281572.1_31325001_1 - 4.7e-28 98.0 0.0 7.1e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.17 001281572.1_31325001_1 - 3.2e-18 66.0 3.5 9.8e-18 64.4 3.5 1.9 1 0 0 1 1 1 1 Regulator of G protein signaling domain PH PF00169.27 001281572.1_31325001_1 - 2.2e-11 44.0 0.1 4e-11 43.2 0.1 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.4 001281572.1_31325001_1 - 0.0011 18.3 0.0 0.0018 17.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like ATG16 PF08614.9 001281572.1_31325001_1 - 0.28 11.2 2.1 0.21 11.6 0.2 1.7 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) PEX11 PF05648.12 001271573.1_26226001_1 - 9.4e-47 159.2 0.1 1.3e-46 158.8 0.1 1.1 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) PEX11 PF05648.12 001271573.1_26226001_3 - 0.046 13.1 0.1 0.075 12.4 0.1 1.3 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Guanylate_kin PF00625.19 007862.3_32929001_2 - 7.9e-66 221.1 1.3 1.4e-65 220.3 1.3 1.4 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 007862.3_32929001_2 - 4.2e-61 203.1 8.0 2.1e-19 69.5 0.1 3.4 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) MAGUK_N_PEST PF10608.7 007862.3_32929001_2 - 8.4e-55 184.2 8.7 8.4e-55 184.2 8.7 1.8 2 0 0 2 2 2 1 Polyubiquitination (PEST) N-terminal domain of MAGUK L27_1 PF09058.8 007862.3_32929001_2 - 1.4e-29 101.8 4.3 3.4e-29 100.6 4.3 1.7 1 0 0 1 1 1 1 L27_1 PDZ_assoc PF10600.7 007862.3_32929001_2 - 2.1e-24 86.0 3.3 8e-24 84.1 3.3 2.1 1 0 0 1 1 1 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.4 007862.3_32929001_2 - 4.6e-16 58.8 0.5 0.00034 20.8 0.1 3.6 3 0 0 3 3 3 3 PDZ domain SH3_1 PF00018.26 007862.3_32929001_2 - 8.3e-08 31.6 0.1 1.9e-07 30.4 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 007862.3_32929001_2 - 1.2e-07 31.2 0.0 2.7e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 007862.3_32929001_2 - 0.014 15.1 0.0 0.032 13.9 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Lipocalin PF00061.21 001279691.1_24222001_1 - 1.3e-35 122.6 0.0 1.5e-35 122.4 0.0 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Triabin PF03973.11 001279691.1_24222001_1 - 0.00059 19.6 0.1 0.00093 19.0 0.1 1.5 1 1 0 1 1 1 1 Triabin Ion_trans PF00520.29 013568.6_32929001_1 - 1.7e-49 168.2 1.1 2.5e-49 167.6 1.1 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 013568.6_32929001_1 - 4e-26 91.1 0.0 6.2e-26 90.5 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 013568.6_32929001_1 - 8.5e-12 44.8 7.0 8.5e-12 44.8 7.0 2.1 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.10 013568.6_32929001_1 - 0.047 12.2 2.8 0.085 11.4 2.8 1.4 1 1 0 1 1 1 0 Polycystin cation channel Fanconi_C PF02106.13 001243744.1_26226001_2 - 7.9e-226 751.0 6.8 1e-225 750.6 6.8 1.0 1 0 0 1 1 1 1 Fanconi anaemia group C protein UQ_con PF00179.24 001256355.1_26227001_1 - 4.1e-42 143.0 0.4 4.1e-42 143.0 0.4 2.3 3 0 0 3 3 3 1 Ubiquitin-conjugating enzyme RWD PF05773.20 001256355.1_26227001_1 - 0.00043 20.4 1.4 0.0016 18.6 0.1 2.1 2 0 0 2 2 2 1 RWD domain UEV PF05743.11 001256355.1_26227001_1 - 0.00069 19.3 2.2 0.0028 17.4 0.1 2.3 2 0 0 2 2 2 1 UEV domain Prok-E2_B PF14461.4 001256355.1_26227001_1 - 0.0011 18.5 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B LRR_8 PF13855.4 001283830.1_29528001_2 - 2e-48 161.8 58.9 3.4e-14 52.2 2.6 5.5 1 1 4 6 6 6 6 Leucine rich repeat LRR_4 PF12799.5 001283830.1_29528001_2 - 2.3e-17 62.6 40.0 0.00012 22.2 0.5 6.2 1 1 3 7 7 7 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001283830.1_29528001_2 - 2.5e-09 36.7 5.7 0.00013 21.4 2.4 3.1 1 1 2 3 3 3 2 Leucine-rich repeat LRRNT PF01462.16 001283830.1_29528001_2 - 1.2e-05 24.7 0.6 6.1e-05 22.4 0.6 2.4 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.4 001283830.1_29528001_2 - 0.00022 20.9 22.9 4.6 7.4 0.0 8.5 8 0 0 8 8 8 2 Leucine Rich repeat LRR_1 PF00560.31 001283830.1_29528001_2 - 0.00044 20.2 37.0 2 9.0 0.7 10.5 10 1 0 10 10 10 1 Leucine Rich Repeat LRR_2 PF07723.11 001283830.1_29528001_2 - 0.77 10.4 6.3 10 6.9 0.1 5.1 4 1 1 5 5 5 0 Leucine Rich Repeat Acetyltransf_1 PF00583.23 001283948.1_29523001_1 - 2.1e-14 53.6 0.1 3.6e-14 52.9 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 001283948.1_29523001_1 - 2.2e-09 37.2 0.0 3.8e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 001283948.1_29523001_1 - 6.4e-09 36.0 0.1 1.3e-08 35.0 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 001283948.1_29523001_1 - 6.8e-08 32.2 0.1 1.3e-07 31.3 0.1 1.4 1 0 0 1 1 1 1 FR47-like protein DUF4604 PF15377.4 001283948.1_29523001_1 - 0.0017 18.7 10.3 0.0017 18.7 10.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4604) Acetyltransf_9 PF13527.5 001283948.1_29523001_1 - 0.019 14.9 0.0 0.037 14.0 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Anoctamin PF04547.10 001283948.1_29523001_1 - 1.3 7.6 6.2 1.7 7.2 6.2 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel DUF4604 PF15377.4 001283948.1_29523001_2 - 0.0058 17.0 10.7 0.0058 17.0 10.7 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4604) BLOC1_2 PF10046.7 001287735.1_29523001_2 - 7.8e-35 118.9 7.0 1.1e-34 118.4 7.0 1.2 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 GTF2I PF02946.12 005685.3_26227001_1 - 7.9e-156 506.3 8.2 5.1e-31 106.4 0.1 5.2 5 0 0 5 5 5 5 GTF2I-like repeat ANF_receptor PF01094.26 008167.2_32927001_1 - 2.4e-49 168.2 0.1 7e-49 166.7 0.0 1.8 2 0 0 2 2 2 1 Receptor family ligand binding region Lig_chan PF00060.24 008167.2_32927001_1 - 7.1e-42 142.6 0.4 1.2e-41 141.9 0.4 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 008167.2_32927001_1 - 1.8e-35 121.4 0.0 3.6e-35 120.5 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 008167.2_32927001_1 - 2.2e-20 72.9 0.0 4.1e-20 72.0 0.0 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Desmo_N PF06771.9 008167.2_32927001_1 - 0.028 14.6 0.1 0.075 13.3 0.1 1.7 1 0 0 1 1 1 0 Viral Desmoplakin N-terminus Myc_target_1 PF15179.4 008167.2_32927001_1 - 0.1 12.3 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Myc target protein 1 RNase_H PF00075.22 008167.2_32927001_1 - 0.17 11.9 0.1 0.38 10.8 0.1 1.5 1 0 0 1 1 1 0 RNase H P5-ATPase PF12409.6 008167.2_32927001_1 - 0.52 10.3 2.9 17 5.4 1.3 2.8 2 0 0 2 2 2 0 P5-type ATPase cation transporter TPT PF03151.14 001252573.1_32925001_1 - 3.4e-24 85.6 14.1 4.5e-24 85.2 14.1 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.18 001252573.1_32925001_1 - 1.2e-06 28.6 39.5 8.1e-06 25.9 12.2 2.3 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.9 001252573.1_32925001_1 - 2.4e-05 23.6 20.4 3e-05 23.2 20.4 1.1 1 0 0 1 1 1 1 UAA transporter family SPC25 PF06703.9 001252573.1_32925001_1 - 7.2 6.2 6.7 9.7 5.8 0.7 2.3 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) bZIP_2 PF07716.13 001287579.1_45726001_2 - 2e-15 56.5 15.2 2e-15 56.5 15.2 1.6 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.19 001287579.1_45726001_2 - 7.3e-05 22.7 7.1 0.00014 21.8 7.1 1.4 1 0 0 1 1 1 1 bZIP transcription factor Taxilin PF09728.7 001287579.1_45726001_2 - 0.019 14.1 1.7 0.025 13.7 1.7 1.1 1 0 0 1 1 1 0 Myosin-like coiled-coil protein bZIP_Maf PF03131.15 001287579.1_45726001_2 - 0.046 14.1 6.4 0.081 13.3 6.4 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor Lipoprotein_20 PF13942.4 001287579.1_45726001_2 - 0.05 13.4 3.7 0.088 12.6 3.7 1.3 1 0 0 1 1 1 0 YfhG lipoprotein TolA_bind_tri PF16331.3 001287579.1_45726001_2 - 0.064 13.2 1.7 0.11 12.4 1.7 1.3 1 0 0 1 1 1 0 TolA binding protein trimerisation Hema_stalk PF08720.8 001287579.1_45726001_2 - 0.18 11.3 0.3 0.29 10.7 0.3 1.2 1 0 0 1 1 1 0 Influenza C hemagglutinin stalk Nup54 PF13874.4 001287579.1_45726001_2 - 0.26 11.2 3.6 0.42 10.6 3.6 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 DivIC PF04977.13 001287579.1_45726001_2 - 0.28 10.9 1.5 0.59 9.8 1.5 1.4 1 0 0 1 1 1 0 Septum formation initiator Ribosomal_S2 PF00318.18 080452.3_32925001_2 - 2.9e-42 144.2 0.7 4.6e-21 74.9 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 Sulfatase PF00884.21 001283217.1_29526001_3 - 2e-83 280.2 0.0 2.9e-83 279.7 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.4 001283217.1_29526001_3 - 2.1e-43 147.8 0.2 3.3e-43 147.2 0.2 1.3 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.20 001283217.1_29526001_3 - 4.5e-10 39.5 0.2 0.00037 20.1 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase ETS_PEA3_N PF04621.11 001261437.1_26225001_3 - 5.9e-105 351.8 7.3 1.3e-104 350.7 7.3 1.5 1 1 0 1 1 1 1 PEA3 subfamily ETS-domain transcription factor N terminal domain Ets PF00178.20 001261437.1_26225001_3 - 2.6e-38 130.2 0.1 4.4e-38 129.5 0.1 1.4 1 0 0 1 1 1 1 Ets-domain Voltage_CLC PF00654.18 001172930.1_09926001_2 - 1.8e-76 257.6 17.8 1.8e-76 257.6 17.8 1.8 1 1 1 2 2 2 1 Voltage gated chloride channel CBS PF00571.26 001172930.1_09926001_2 - 0.0002 21.6 0.8 0.25 11.7 0.1 2.5 2 0 0 2 2 2 2 CBS domain Hormone_1 PF00103.18 001285547.1_09022001_1 - 2.1e-81 272.6 0.0 2.5e-81 272.4 0.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family Protamine_P2 PF00841.17 001257256.1_08022001_1 - 7.4e-34 116.0 40.7 7.4e-34 116.0 40.7 2.3 2 1 1 3 3 3 1 Sperm histone P2 CENP-W PF15510.4 001246319.1_45724001_1 - 5.8e-41 138.5 5.5 9.5e-41 137.8 5.5 1.4 1 0 0 1 1 1 1 CENP-W protein Casein PF00363.16 001285695.1_09022001_1 - 2.1e-24 85.8 3.6 4.9e-24 84.7 3.0 1.8 2 0 0 2 2 2 1 Casein MF_alpha_N PF05436.9 001285695.1_09022001_1 - 0.13 12.0 0.0 12 5.8 0.0 2.3 2 0 0 2 2 2 0 Mating factor alpha precursor N-terminus KCNQ_channel PF03520.12 001134643.2_45728001_3 - 5e-93 310.1 2.0 8.1e-93 309.4 2.0 1.4 1 0 0 1 1 1 1 KCNQ voltage-gated potassium channel Ion_trans PF00520.29 001134643.2_45728001_3 - 7.2e-26 90.8 11.5 1e-25 90.3 11.5 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.14 001134643.2_45728001_3 - 5.3e-14 51.8 5.3 5.3e-14 51.8 5.3 1.8 2 0 0 2 2 2 1 Ion channel IQ PF00612.25 001134643.2_45728001_3 - 5.7 6.9 11.7 3.1 7.7 0.0 3.6 3 0 0 3 3 3 0 IQ calmodulin-binding motif Sulfatase PF00884.21 001285690.1_09025001_1 - 2.9e-70 237.0 0.3 3.8e-70 236.6 0.3 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.20 001285690.1_09025001_1 - 9.8e-06 25.2 0.0 0.007 15.9 0.0 2.1 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.3 001285690.1_09025001_1 - 0.0013 18.8 0.0 3 8.0 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4976) UPF0669 PF17065.3 001287704.1_29526001_3 - 1.3e-98 328.0 0.0 1.7e-98 327.7 0.0 1.1 1 0 0 1 1 1 1 Putative cytokine, C6ORF120 BRO1 PF03097.16 001164677.1_32929001_3 - 7.2e-113 377.2 4.8 1.4e-112 376.2 4.8 1.5 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.4 001164677.1_32929001_3 - 1.7e-92 309.7 11.5 1.7e-92 309.7 11.5 2.0 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV Ribosomal_S7e PF01251.16 011300.3_32922001_3 - 3.1e-93 310.5 3.8 3.6e-93 310.3 3.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e P53 PF00870.16 001202405.1_21023001_1 - 1.1e-113 377.5 0.7 1.6e-113 376.9 0.7 1.2 1 0 0 1 1 1 1 P53 DNA-binding domain P53_tetramer PF07710.9 001202405.1_21023001_1 - 3.5e-18 64.5 1.5 6.9e-18 63.6 1.5 1.5 1 0 0 1 1 1 1 P53 tetramerisation motif P53_TAD PF08563.9 001202405.1_21023001_1 - 9.2e-14 50.3 2.2 2.2e-13 49.1 2.2 1.7 1 0 0 1 1 1 1 P53 transactivation motif CEP1-DNA_bind PF09287.8 001202405.1_21023001_1 - 0.18 11.3 0.0 0.27 10.7 0.0 1.2 1 0 0 1 1 1 0 CEP-1, DNA binding Far-17a_AIG1 PF04750.12 016108.3_26223001_1 - 1.8e-75 252.6 10.6 2.3e-75 252.2 10.6 1.1 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Lipocalin PF00061.21 001285539.1_09022001_2 - 9.4e-38 129.5 0.0 1.1e-37 129.3 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family PACT_coil_coil PF10495.7 001037093.2_45729001_1 - 7.1e-25 87.3 0.0 7.1e-25 87.3 0.0 6.9 7 1 0 8 8 8 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein Rootletin PF15035.4 001037093.2_45729001_1 - 0.0015 18.5 5.3 0.0015 18.5 5.3 22.2 8 5 10 18 18 18 1 Ciliary rootlet component, centrosome cohesion Forkhead PF00250.16 017077.2_45723001_2 - 1.1e-36 124.9 0.2 1.7e-36 124.2 0.2 1.3 1 0 0 1 1 1 1 Forkhead domain Forkhead_N PF08430.10 017077.2_45723001_2 - 6.8e-07 29.8 2.0 6.8e-07 29.8 2.0 3.1 2 1 0 2 2 2 1 Forkhead N-terminal region HNF_C PF09354.8 017077.2_45723001_2 - 4.5e-05 24.3 0.3 0.00028 21.8 0.0 2.5 2 0 0 2 2 2 1 HNF3 C-terminal domain Ribosomal_60s PF00428.17 017077.2_45723001_2 - 0.061 13.7 0.2 0.11 13.0 0.2 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein Lamp PF01299.15 017077.2_45723001_2 - 1.8 7.9 3.8 2.8 7.3 3.8 1.2 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) Kunitz_BPTI PF00014.21 001164006.1_49824001_2 - 8.3e-33 112.3 23.3 2.1e-16 59.8 8.5 2.5 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Lipocalin PF00061.21 001164006.1_49824001_2 - 1.7e-27 96.3 0.1 2.3e-27 95.8 0.1 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.10 001164006.1_49824001_2 - 0.14 12.0 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipocalin-like domain YajC PF02699.13 001285110.1_29524001_2 - 0.24 11.2 1.9 0.45 10.3 1.9 1.4 1 0 0 1 1 1 0 Preprotein translocase subunit SNAPc_SNAP43 PF09808.7 001285110.1_29524001_3 - 4.4e-66 222.3 5.6 7.9e-66 221.5 5.6 1.4 1 0 0 1 1 1 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 Thymosin PF01290.18 001163948.1_21022001_2 - 4.5e-22 77.3 10.6 7.8e-22 76.6 10.6 1.4 1 0 0 1 1 1 1 Thymosin beta-4 family WH2 PF02205.18 001163948.1_21022001_2 - 0.026 14.2 0.1 0.041 13.6 0.1 1.3 1 0 0 1 1 1 0 WH2 motif Glycolytic PF00274.17 001271536.1_45723001_2 - 2e-189 628.5 0.0 2.3e-189 628.3 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I P2X_receptor PF00864.17 174873.2_26224001_2 - 2.1e-145 484.3 0.0 2.5e-145 484.0 0.0 1.0 1 0 0 1 1 1 1 ATP P2X receptor CENP-Q PF13094.4 031863.3_32923001_2 - 5.5e-16 59.0 12.5 5.5e-16 59.0 12.5 2.0 2 0 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit DUF812 PF05667.9 031863.3_32923001_2 - 0.0026 16.6 15.0 0.0034 16.2 15.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF342 PF03961.11 031863.3_32923001_2 - 0.23 9.9 9.5 0.37 9.2 9.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF948 PF06103.9 031863.3_32923001_2 - 0.27 11.4 3.2 0.82 9.8 3.2 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.10 031863.3_32923001_2 - 0.69 9.8 9.1 2.4 8.0 9.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF1465 PF07323.10 031863.3_32923001_2 - 0.75 9.5 8.1 0.43 10.3 1.7 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1465) DUF848 PF05852.9 031863.3_32923001_2 - 4.1 7.4 9.4 0.45 10.5 2.8 2.2 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) CLZ PF16526.3 031863.3_32923001_2 - 4.5 7.6 9.1 1.7 8.9 5.0 2.4 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels BST2 PF16716.3 031863.3_32923001_2 - 8.5 6.9 14.8 9.7 6.7 10.9 2.7 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 IRK PF01007.18 002243.4_26226001_2 - 5.1e-136 452.8 1.7 7.9e-136 452.2 1.7 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 002243.4_26226001_2 - 0.0079 16.0 3.4 0.017 14.9 3.4 1.6 1 0 0 1 1 1 1 Ion channel DUF2182 PF09948.7 002243.4_26226001_2 - 0.12 12.2 0.1 0.22 11.3 0.1 1.3 1 0 0 1 1 1 0 Predicted metal-binding integral membrane protein (DUF2182) Forkhead PF00250.16 001244665.1_49823001_1 - 2.3e-38 130.3 0.0 3.2e-38 129.8 0.0 1.2 1 0 0 1 1 1 1 Forkhead domain Kunitz_BPTI PF00014.21 001195022.1_29622001_1 - 3.1e-55 184.1 44.5 5.6e-19 68.0 8.5 3.2 3 0 0 3 3 3 3 Kunitz/Bovine pancreatic trypsin inhibitor domain Tubulin PF00091.23 001166505.1_06524001_1 - 9.6e-69 231.4 0.0 1.3e-68 231.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001166505.1_06524001_1 - 3.4e-51 172.6 0.0 5.5e-51 171.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 001166505.1_06524001_1 - 0.0023 17.5 0.0 0.0043 16.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Ras PF00071.20 001283960.1_29525001_1 - 5.1e-62 208.1 0.1 6.9e-62 207.7 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001283960.1_29525001_1 - 3.4e-32 111.1 0.0 6.8e-32 110.1 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001283960.1_29525001_1 - 3.5e-12 46.0 0.0 5.4e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001283960.1_29525001_1 - 0.00047 20.1 0.0 0.0008 19.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001283960.1_29525001_1 - 0.0023 17.2 0.0 0.0034 16.6 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001283960.1_29525001_1 - 0.0057 16.1 0.1 0.017 14.6 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001283960.1_29525001_1 - 0.012 15.4 0.0 1.3 8.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DUF1467 PF07330.10 001283960.1_29525001_2 - 0.48 10.3 3.4 0.83 9.5 3.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1467) ACOX PF01756.17 001271898.1_32928001_3 - 3.2e-64 215.7 0.9 5.2e-64 215.0 0.5 1.6 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.4 001271898.1_32928001_3 - 2.5e-35 121.6 0.6 1.6e-34 119.0 0.2 2.2 2 0 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.17 001271898.1_32928001_3 - 6e-11 42.3 0.0 1e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.22 001271898.1_32928001_3 - 0.0024 18.0 0.0 0.015 15.4 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Glycolytic PF00274.17 012495.2_45723001_3 - 2.1e-189 628.5 0.0 2.4e-189 628.3 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Acatn PF13000.5 004733.3_26228001_1 - 1.8e-121 406.2 16.3 1.6e-73 248.0 7.3 3.0 1 1 1 2 2 2 2 Acetyl-coenzyme A transporter 1 Spt4 PF06093.11 001284797.1_29524001_1 - 1.4e-31 108.3 0.3 2.3e-31 107.6 0.3 1.3 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Myc_N PF01056.16 001173446.1_22423001_1 - 2.8e-118 395.4 7.1 2.8e-118 395.4 7.1 1.3 2 0 0 2 2 2 1 Myc amino-terminal region Myc-LZ PF02344.13 001173446.1_22423001_1 - 2.4e-16 59.4 10.0 2.4e-16 59.4 10.0 2.1 2 0 0 2 2 2 1 Myc leucine zipper domain HLH PF00010.24 001173446.1_22423001_1 - 1.3e-15 56.9 7.4 2.4e-14 52.9 1.5 2.9 3 0 0 3 3 3 2 Helix-loop-helix DNA-binding domain GTP-bdg_M PF16360.3 001173446.1_22423001_1 - 0.7 10.4 4.2 0.49 10.9 2.1 1.8 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region Choline_transpo PF04515.10 001173016.1_09925001_1 - 3.7e-109 364.7 43.2 5e-109 364.3 28.7 2.6 3 0 0 3 3 3 2 Plasma-membrane choline transporter LAT PF15234.4 001173016.1_09925001_1 - 0.21 11.2 0.2 0.39 10.3 0.2 1.4 1 0 0 1 1 1 0 Linker for activation of T-cells Cadherin PF00028.15 031264.3_26226001_1 - 1.2e-14 54.3 1.3 0.00016 21.9 0.0 3.9 4 0 0 4 4 4 3 Cadherin domain Cadherin_3 PF16184.3 031264.3_26226001_1 - 0.00022 21.1 0.2 0.0013 18.6 0.1 2.3 3 0 0 3 3 3 1 Cadherin-like MIF4G PF02854.17 001082667.2_37929001_1 - 4.5e-69 232.2 10.8 7.5e-69 231.5 10.8 1.4 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.15 001082667.2_37929001_1 - 2.8e-30 104.5 0.3 2.1e-29 101.6 0.1 2.5 2 1 0 2 2 2 1 MA3 domain W2 PF02020.16 001082667.2_37929001_1 - 1.3e-18 66.7 2.7 1.3e-18 66.7 2.7 2.3 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Cep57_MT_bd PF06657.11 001082667.2_37929001_1 - 3 8.2 7.4 0.86 10.0 3.0 2.4 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 IL10 PF00726.15 001260485.1_09922001_1 - 1.5e-101 336.9 0.8 1.8e-101 336.6 0.8 1.0 1 0 0 1 1 1 1 Interleukin 10 IL22 PF14565.4 001260485.1_09922001_1 - 1.7e-07 31.5 0.3 2.2e-07 31.1 0.3 1.1 1 0 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor CPL PF08144.9 001260485.1_09922001_3 - 0.047 13.9 0.0 0.17 12.1 0.0 1.7 2 0 0 2 2 2 0 CPL (NUC119) domain UDPGT PF00201.16 001039691.2_45725001_1 - 5.6e-230 764.2 0.0 7.4e-230 763.8 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001039691.2_45725001_1 - 2.7e-07 30.6 0.0 4.8e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 001039691.2_45725001_1 - 0.028 14.3 0.0 0.07 13.0 0.0 1.6 1 0 0 1 1 1 0 Glycosyltransferase Family 4 PHD PF00628.27 001287286.1_29524001_1 - 3.5e-09 36.3 9.4 7.7e-09 35.2 9.4 1.6 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.20 001287286.1_29524001_1 - 2.5e-05 24.0 2.9 2.5e-05 24.0 2.9 2.1 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.4 001287286.1_29524001_1 - 0.0001 22.0 3.3 0.00028 20.6 3.3 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 PHD_2 PF13831.4 001287286.1_29524001_1 - 0.0033 16.8 4.6 0.009 15.4 4.6 1.8 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.3 001287286.1_29524001_1 - 0.0041 17.1 8.5 0.012 15.6 8.5 1.8 1 1 0 1 1 1 1 PHD-finger zf-PHD-like PF15446.4 001287286.1_29524001_1 - 0.0047 16.4 3.6 0.0099 15.4 3.6 1.5 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain FYVE_2 PF02318.14 001287286.1_29524001_1 - 4.3 7.4 10.2 0.8 9.8 5.4 2.2 2 0 0 2 2 2 0 FYVE-type zinc finger 7tm_1 PF00001.19 001283360.1_29524001_3 - 1.2e-47 162.3 12.4 1.8e-47 161.7 12.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Rhodopsin_N PF10413.7 001283360.1_29524001_3 - 1.1e-23 82.6 3.7 3.2e-23 81.1 3.7 1.9 1 0 0 1 1 1 1 Amino terminal of the G-protein receptor rhodopsin 7TM_GPCR_Srv PF10323.7 001283360.1_29524001_3 - 4.7e-11 42.4 18.3 7.5e-11 41.8 18.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.7 001283360.1_29524001_3 - 1e-10 41.3 16.6 6.4e-10 38.7 16.6 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.7 001283360.1_29524001_3 - 1.9e-08 33.9 15.9 2.9e-08 33.3 15.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TAS2R PF05296.11 001283360.1_29524001_3 - 0.00055 19.0 11.6 0.00098 18.2 4.1 2.2 2 0 0 2 2 2 2 Taste receptor protein (TAS2R) 7tm_4 PF13853.4 001283360.1_29524001_3 - 0.0013 18.4 15.6 0.007 16.0 15.6 1.9 1 1 0 1 1 1 1 Olfactory receptor DUF4079 PF13301.4 001283360.1_29524001_3 - 3.4 7.7 6.1 17 5.4 2.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) 7TM_GPCR_Srh PF10318.7 001283360.1_29524001_3 - 7.7 5.3 28.9 53 2.5 28.9 2.0 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srh Tubulin PF00091.23 016261.3_26226001_1 - 4.1e-61 206.5 0.6 6e-61 206.0 0.6 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.4 016261.3_26226001_1 - 0.0014 17.8 0.0 0.0023 17.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin like GSHPx PF00255.17 001287642.1_29524001_2 - 3.9e-44 148.5 0.3 5.4e-44 148.1 0.3 1.2 1 0 0 1 1 1 1 Glutathione peroxidase IRK PF01007.18 001281841.1_31325001_2 - 2.5e-142 473.5 0.3 3.5e-142 473.1 0.3 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 001281841.1_31325001_2 - 0.026 14.4 8.1 0.075 12.9 8.1 1.8 1 1 0 1 1 1 0 Ion channel G-gamma PF00631.20 001017998.3_26223001_2 - 1.6e-14 53.5 0.0 2.5e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 GGL domain Ras PF00071.20 001277334.1_45725001_1 - 1.5e-50 170.8 0.0 3.2e-50 169.8 0.0 1.5 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001277334.1_45725001_1 - 6.8e-30 103.6 0.2 1.9e-29 102.2 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001277334.1_45725001_1 - 2.9e-17 62.5 0.0 1.3e-16 60.4 0.0 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family EF-hand_1 PF00036.30 001277334.1_45725001_1 - 3.9e-09 35.3 0.0 0.0042 16.4 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 001277334.1_45725001_1 - 1.2e-08 35.1 0.3 7.7e-08 32.6 0.0 2.6 3 1 0 3 3 2 1 EF-hand domain pair EF-hand_6 PF13405.4 001277334.1_45725001_1 - 1.4e-08 33.9 0.0 0.0068 16.1 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain MMR_HSR1 PF01926.21 001277334.1_45725001_1 - 1.3e-07 31.5 0.0 4.3e-07 29.9 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase EF-hand_5 PF13202.4 001277334.1_45725001_1 - 2.3e-07 29.9 0.0 0.023 14.1 0.0 3.0 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 001277334.1_45725001_1 - 4.5e-07 29.4 0.0 1.7e-05 24.4 0.0 2.8 1 1 1 2 2 2 2 EF-hand domain pair GTP_EFTU PF00009.25 001277334.1_45725001_1 - 0.00093 18.6 0.0 0.00093 18.6 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Reo_sigmaC PF04582.10 001277334.1_45725001_1 - 0.0013 18.1 6.4 0.0022 17.3 5.4 1.9 1 1 0 1 1 1 1 Reovirus sigma C capsid protein TPR_MLP1_2 PF07926.10 001277334.1_45725001_1 - 0.004 17.1 9.3 0.004 17.1 9.3 3.5 1 1 2 3 3 3 1 TPR/MLP1/MLP2-like protein DUF258 PF03193.14 001277334.1_45725001_1 - 0.13 12.0 3.2 0.85 9.4 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function, DUF258 AAA_25 PF13481.4 001277334.1_45725001_1 - 0.14 11.6 0.4 0.39 10.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.4 001277334.1_45725001_1 - 0.15 12.1 8.3 0.5 10.4 0.0 3.7 3 1 0 3 3 3 0 AAA domain SPARC_Ca_bdg PF10591.7 001277334.1_45725001_1 - 0.17 12.1 5.4 0.34 11.1 0.0 3.1 2 1 0 2 2 1 0 Secreted protein acidic and rich in cysteine Ca binding region GIT_CC PF16559.3 001277334.1_45725001_1 - 3.5 7.6 12.7 14 5.7 2.5 3.9 1 1 3 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor Rootletin PF15035.4 001277334.1_45725001_1 - 4.7 7.1 27.3 5.6 6.9 19.6 2.6 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion TSC22 PF01166.16 001277334.1_45725001_1 - 7.7 6.8 9.4 5.2 7.3 0.3 3.4 3 1 0 3 3 2 0 TSC-22/dip/bun family MIF4G PF02854.17 001198802.1_26229001_2 - 3.3e-68 229.4 7.3 7.6e-68 228.2 7.3 1.7 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.15 001198802.1_26229001_2 - 8.1e-31 106.2 0.2 2.4e-30 104.7 0.2 1.9 1 0 0 1 1 1 1 MA3 domain W2 PF02020.16 001198802.1_26229001_2 - 4e-18 65.2 1.4 4e-18 65.2 1.4 2.6 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon PP_kinase PF02503.15 001198802.1_26229001_2 - 0.019 14.4 1.3 0.043 13.3 1.3 1.5 1 0 0 1 1 1 0 Polyphosphate kinase middle domain DUF1476 PF07345.9 001198802.1_26229001_2 - 2.4 8.4 5.7 1.5 9.1 2.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1476) Citrate_synt PF00285.19 001285124.1_29524001_1 - 3.9e-105 351.8 0.0 5.3e-105 351.3 0.0 1.2 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Queuosine_synth PF02547.13 001285124.1_29524001_1 - 0.05 12.6 0.0 0.081 11.9 0.0 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein PAS_3 PF08447.10 001285124.1_29524001_1 - 0.084 13.0 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 PAS fold PCI PF01399.25 001284810.1_29524001_1 - 7.7e-20 71.2 1.1 2.6e-19 69.5 0.2 2.3 2 0 0 2 2 2 1 PCI domain RasGEF PF00617.17 001284810.1_29524001_1 - 0.0031 17.6 0.4 0.48 10.5 0.1 3.0 3 0 0 3 3 3 1 RasGEF domain TPR_1 PF00515.26 001284810.1_29524001_1 - 0.012 15.3 2.7 0.021 14.5 0.9 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.15 001284810.1_29524001_1 - 0.07 13.1 2.6 0.2 11.7 0.9 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.10 001284810.1_29524001_1 - 0.085 13.4 1.0 0.22 12.1 1.0 1.8 1 0 0 1 1 1 0 Sel1 repeat TPR_12 PF13424.4 001284810.1_29524001_1 - 0.12 12.6 0.1 3.2 8.0 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.4 001284810.1_29524001_1 - 0.36 11.0 3.5 2 8.7 0.4 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 001284810.1_29524001_1 - 0.38 10.6 1.3 1.8 8.5 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.15 001100850.1_45729001_2 - 9.8e-99 329.7 0.0 1.3e-98 329.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001100850.1_45729001_2 - 3.3e-48 164.2 0.0 5.3e-48 163.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain F_actin_bind PF08919.8 001100850.1_45729001_2 - 9.5e-28 96.4 0.2 1.7e-27 95.6 0.2 1.4 1 0 0 1 1 1 1 F-actin binding SH2 PF00017.22 001100850.1_45729001_2 - 2.2e-23 81.9 0.2 5.1e-23 80.8 0.2 1.7 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001100850.1_45729001_2 - 3.1e-12 45.8 0.0 5.3e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001100850.1_45729001_2 - 2.2e-08 33.7 0.0 4.1e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001100850.1_45729001_2 - 2.9e-07 29.9 0.0 5.8e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 001100850.1_45729001_2 - 0.00012 22.2 0.2 0.00029 20.9 0.2 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain zf-H2C2_2 PF13465.4 001289041.1_26226001_1 - 6.9e-09 35.6 40.3 2.4e-05 24.4 3.1 6.9 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2 PF00096.24 001289041.1_26226001_1 - 0.00081 19.6 58.1 0.0014 18.9 7.3 6.4 7 0 0 7 7 7 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001289041.1_26226001_1 - 0.0066 17.0 9.6 0.0096 16.5 4.8 7.9 9 0 0 9 9 9 4 C2H2-type zinc finger zf-met PF12874.5 001289041.1_26226001_1 - 0.02 15.2 4.6 0.02 15.2 4.6 4.6 4 0 0 4 4 4 0 Zinc-finger of C2H2 type Carb_anhydrase PF00194.19 001195708.1_37923001_3 - 5.2e-99 330.8 0.0 6.1e-99 330.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Pacs-1 PF10254.7 001243127.2_26229001_3 - 5.4e-202 671.1 0.0 7.8e-202 670.6 0.0 1.2 1 0 0 1 1 1 1 PACS-1 cytosolic sorting protein IGF2_C PF08365.9 031511.2_45729001_2 - 3.7e-25 87.6 1.9 3.7e-25 87.6 1.9 1.8 2 0 0 2 2 2 1 Insulin-like growth factor II E-peptide Insulin PF00049.16 031511.2_45729001_2 - 1e-11 45.5 5.2 5.2e-06 27.2 1.9 2.4 1 1 1 2 2 2 2 Insulin/IGF/Relaxin family CTF_NFI PF00859.16 001281939.1_31324001_1 - 7.1e-07 29.3 0.1 1.2e-06 28.6 0.1 1.3 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region CTF_NFI PF00859.16 001281939.1_31324001_2 - 2.2e-95 319.8 11.2 2.2e-95 319.8 11.2 1.7 2 0 0 2 2 2 1 CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N PF10524.7 001281939.1_31324001_2 - 1.5e-27 95.1 2.6 2.5e-27 94.4 2.6 1.4 1 0 0 1 1 1 1 Nuclear factor I protein pre-N-terminus MH1 PF03165.14 001281939.1_31324001_2 - 7.4e-11 42.0 0.1 1.4e-10 41.1 0.1 1.5 1 0 0 1 1 1 1 MH1 domain Insulin PF00049.16 001008996.2_39721001_3 - 1e-25 90.4 1.1 1.3e-25 90.1 1.1 1.1 1 0 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 001008996.2_39721001_3 - 0.11 12.4 5.9 0.59 10.0 0.2 2.2 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type G-alpha PF00503.18 001172953.1_09923001_1 - 1.5e-125 418.9 3.4 1.8e-125 418.7 3.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 001172953.1_09923001_1 - 4.3e-18 65.3 0.2 3.5e-13 49.3 0.1 2.7 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001172953.1_09923001_1 - 1.7e-05 24.2 3.1 0.0029 16.8 1.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 001172953.1_09923001_1 - 0.00012 22.2 0.4 0.47 10.6 0.1 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 001172953.1_09923001_1 - 0.068 13.4 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Ras PF00071.20 001172953.1_09923001_1 - 0.083 12.4 2.2 3.4 7.1 0.8 2.5 2 0 0 2 2 2 0 Ras family TniB PF05621.9 001172953.1_09923001_1 - 0.096 11.7 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.4 001172953.1_09923001_1 - 0.097 12.3 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.16 001172953.1_09923001_1 - 0.12 11.5 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family IGF2_C PF08365.9 001190162.1_45728001_2 - 1.6e-25 88.7 1.9 2.8e-25 88.0 1.9 1.4 1 0 0 1 1 1 1 Insulin-like growth factor II E-peptide Insulin PF00049.16 001190162.1_45728001_2 - 6.2e-12 46.2 5.2 4e-06 27.6 1.9 2.4 1 1 1 2 2 2 2 Insulin/IGF/Relaxin family Myb_DNA-binding PF00249.29 015156.3_26229001_1 - 7.1e-17 61.2 0.0 3.5e-09 36.6 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain ELM2 PF01448.22 015156.3_26229001_1 - 9.6e-14 51.8 0.1 2.5e-13 50.4 0.1 1.8 1 0 0 1 1 1 1 ELM2 domain Myb_DNA-bind_7 PF15963.3 015156.3_26229001_1 - 7.1e-06 25.7 5.1 0.0058 16.4 0.1 2.4 2 0 0 2 2 2 2 Myb DNA-binding like Myb_DNA-bind_6 PF13921.4 015156.3_26229001_1 - 0.0016 18.5 4.3 0.19 11.9 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain APG9 PF04109.14 001288613.1_32929001_1 - 1.1e-130 436.0 0.5 1.3e-130 435.7 0.5 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 PRRSV_2b PF07069.9 001288613.1_32929001_2 - 0.062 13.7 0.9 0.13 12.7 0.9 1.4 1 0 0 1 1 1 0 Porcine reproductive and respiratory syndrome virus 2b WWE PF02825.18 030963.3_26225001_2 - 5.2e-16 58.8 2.5 1.1e-15 57.8 2.5 1.6 1 0 0 1 1 1 1 WWE domain zf-C3HC4_3 PF13920.4 030963.3_26225001_2 - 2.2e-06 27.3 10.7 2.2e-06 27.3 10.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 030963.3_26225001_2 - 0.00033 20.7 12.6 0.00033 20.7 12.6 2.2 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4 PF00097.23 030963.3_26225001_2 - 0.00051 19.7 11.6 0.00051 19.7 11.6 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 030963.3_26225001_2 - 0.00072 19.4 9.7 0.00072 19.4 9.7 2.2 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 030963.3_26225001_2 - 0.0021 17.7 12.0 0.0021 17.7 12.0 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 030963.3_26225001_2 - 0.0085 15.8 10.2 0.022 14.5 10.2 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 030963.3_26225001_2 - 0.06 13.4 7.5 0.17 11.9 7.5 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_11 PF17123.3 030963.3_26225001_2 - 2.1 8.0 10.8 8.7 6.0 10.8 2.2 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_5 PF14634.4 030963.3_26225001_2 - 2.9 7.8 17.9 0.077 12.8 11.4 1.9 2 0 0 2 2 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.4 030963.3_26225001_2 - 7.4 6.7 20.4 0.039 14.0 10.6 2.4 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING Yip1 PF04893.15 001285289.1_29524001_2 - 3e-09 36.7 16.2 4.2e-09 36.2 16.2 1.2 1 0 0 1 1 1 1 Yip1 domain Bestrophin PF01062.19 001282614.1_26224001_3 - 7.2e-110 366.9 5.6 8.7e-110 366.6 5.6 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Ets PF00178.20 001973.3_26229001_3 - 1.3e-34 118.3 2.8 2.4e-34 117.5 2.8 1.4 1 0 0 1 1 1 1 Ets-domain Ras PF00071.20 001172898.1_09922001_1 - 7.1e-58 194.7 0.1 8.1e-58 194.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001172898.1_09922001_1 - 3.9e-21 75.4 0.0 6.9e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001172898.1_09922001_1 - 6e-09 35.5 0.0 7.2e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001172898.1_09922001_1 - 1.1e-06 28.2 0.2 7.1e-06 25.6 0.2 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001172898.1_09922001_1 - 4.3e-06 26.6 0.0 0.021 14.6 0.0 2.3 2 1 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 001172898.1_09922001_1 - 7.8e-05 22.6 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001172898.1_09922001_1 - 0.0012 18.3 0.0 0.0098 15.3 0.0 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.16 001172898.1_09922001_1 - 0.056 12.5 0.0 0.098 11.7 0.0 1.4 1 0 0 1 1 1 0 Septin G-alpha PF00503.18 001172898.1_09922001_1 - 0.061 12.3 0.0 2.8 6.9 0.0 2.0 1 1 1 2 2 2 0 G-protein alpha subunit Ldh_1_N PF00056.21 001172898.1_09922001_1 - 0.068 13.1 0.0 0.41 10.6 0.0 1.9 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain DUF2075 PF09848.7 001172898.1_09922001_1 - 0.1 11.7 0.0 5.6 6.0 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ParA PF10609.7 001172898.1_09922001_1 - 0.12 11.6 0.1 0.48 9.7 0.0 1.8 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase AAA_25 PF13481.4 001172898.1_09922001_1 - 0.19 11.2 0.0 0.4 10.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 001172898.1_09922001_1 - 0.19 11.9 0.1 0.39 10.9 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain MHC_I PF00129.16 001531.2_26229001_3 - 1.3e-55 187.6 0.9 1.9e-55 187.1 0.9 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001531.2_26229001_3 - 3.3e-13 49.8 0.0 6.2e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 001531.2_26229001_3 - 1.6e-09 37.4 0.4 2.5e-09 36.8 0.4 1.2 1 0 0 1 1 1 1 MHC-I family domain Forkhead PF00250.16 001171115.1_37923001_1 - 2.4e-38 130.2 0.0 3.3e-38 129.8 0.0 1.2 1 0 0 1 1 1 1 Forkhead domain zf-H2C2_2 PF13465.4 001185119.1_26229001_2 - 1.1e-46 155.1 37.3 1e-08 35.1 0.9 8.7 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.24 001185119.1_26229001_2 - 5.9e-32 108.2 48.8 2.6e-05 24.3 0.7 7.9 7 0 0 7 7 7 7 Zinc finger, C2H2 type BTB PF00651.29 001185119.1_26229001_2 - 1.2e-24 86.5 0.2 2.4e-24 85.5 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.4 001185119.1_26229001_2 - 4.2e-24 83.0 46.9 0.00083 19.9 0.2 8.2 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001185119.1_26229001_2 - 2.3e-10 40.0 31.6 0.043 13.7 0.1 7.7 7 0 0 7 7 7 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001185119.1_26229001_2 - 3e-10 40.0 20.6 0.026 14.7 0.1 7.4 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001185119.1_26229001_2 - 9.9e-05 22.5 45.3 0.015 15.5 0.3 7.6 8 0 0 8 8 7 3 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.4 001185119.1_26229001_2 - 0.0018 17.8 33.8 0.21 11.2 0.5 8.0 8 0 0 8 8 8 2 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.3 001185119.1_26229001_2 - 0.0035 16.9 0.5 0.0035 16.9 0.5 6.8 7 0 0 7 7 7 2 zinc-finger C2H2-type DUF3268 PF11672.6 001185119.1_26229001_2 - 0.011 15.9 13.2 0.99 9.6 0.4 3.5 3 0 0 3 3 3 0 zinc-finger-containing domain zinc_ribbon_15 PF17032.3 001185119.1_26229001_2 - 0.053 14.1 19.6 8.5 7.1 0.2 4.4 1 1 3 4 4 4 0 zinc-ribbon family zf-C2H2_8 PF15909.3 001185119.1_26229001_2 - 0.096 12.9 15.4 0.3 11.3 6.8 3.3 1 1 1 3 3 3 0 C2H2-type zinc ribbon zf-Di19 PF05605.10 001185119.1_26229001_2 - 0.22 11.7 26.4 0.42 10.8 0.3 4.4 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.8 001185119.1_26229001_2 - 0.71 9.9 24.5 2.1 8.4 2.1 5.3 1 1 5 6 6 6 0 Zinc ribbon domain adh_short PF00106.23 148897.2_26224001_1 - 1.2e-38 132.4 0.0 1.5e-38 132.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 148897.2_26224001_1 - 6e-25 88.0 0.0 8.4e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 148897.2_26224001_1 - 0.0055 16.5 0.0 0.0086 15.9 0.0 1.2 1 0 0 1 1 1 1 KR domain Androgen_recep PF02166.14 214314.2_49826001_2 - 1.4e-236 785.9 42.3 1.8e-236 785.5 42.3 1.1 1 0 0 1 1 1 1 Androgen receptor Hormone_recep PF00104.28 214314.2_49826001_2 - 2.8e-31 108.6 2.9 5.1e-31 107.8 2.9 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 214314.2_49826001_2 - 4.5e-27 94.2 14.4 8.7e-27 93.2 14.4 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Mito_carr PF00153.25 030780.4_26227001_3 - 5.4e-68 224.8 1.0 8.1e-22 76.8 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-SNAP50_C PF12251.6 001284877.1_29526001_1 - 1.9e-77 259.3 4.2 2.8e-77 258.8 4.2 1.2 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal ArfGap PF01412.16 001242832.1_26226001_3 - 5.1e-32 110.2 0.5 1.1e-31 109.1 0.5 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf zf-dskA_traR PF01258.15 001242832.1_26226001_3 - 4.9 7.0 6.9 2.7 7.9 0.1 3.1 3 0 0 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger PRA1 PF03208.17 001283279.1_29523001_1 - 3.7e-29 101.1 1.2 4.7e-29 100.7 1.2 1.1 1 0 0 1 1 1 1 PRA1 family protein Lipocalin_7 PF14651.4 214215.2_49822001_3 - 2.9e-80 266.3 1.1 3.4e-80 266.1 1.1 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Aminotran_1_2 PF00155.19 001284930.1_29524001_2 - 1.2e-93 314.1 0.0 1.4e-93 313.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Serum_albumin PF00273.18 001281649.1_31324001_3 - 5.6e-160 527.6 44.1 2.2e-57 193.5 12.1 3.0 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.8 001281649.1_31324001_3 - 0.074 12.9 33.1 0.19 11.6 0.1 6.8 8 0 0 8 8 8 0 Vitamin D binding protein, domain III dsrm PF00035.24 001164380.1_26227001_3 - 6.8e-45 151.5 2.6 6.8e-13 49.0 0.1 4.6 4 0 0 4 4 4 4 Double-stranded RNA binding motif Staufen_C PF16482.3 001164380.1_26227001_3 - 2.7e-16 59.5 4.8 1.2e-14 54.3 0.2 4.9 6 1 0 6 6 6 1 Staufen C-terminal domain DND1_DSRM PF14709.5 001164380.1_26227001_3 - 2.9e-05 24.1 4.6 1.2 9.3 0.2 5.0 4 2 0 4 4 4 2 double strand RNA binding domain from DEAD END PROTEIN 1 Plant_zn_clust PF10533.7 001080969.3_32928001_1 - 1.1 9.1 6.8 3.3 7.6 6.8 1.9 1 0 0 1 1 1 0 Plant zinc cluster domain Thg1 PF04446.10 001080969.3_32928001_3 - 8.6e-50 167.9 0.2 1.3e-49 167.3 0.2 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.4 001080969.3_32928001_3 - 1.7e-46 157.2 0.2 2.6e-46 156.6 0.2 1.3 1 0 0 1 1 1 1 Thg1 C terminal domain HNF-1_N PF04814.11 001135726.2_26228001_1 - 5.5e-62 209.7 5.1 1e-61 208.8 5.1 1.5 1 0 0 1 1 1 1 Hepatocyte nuclear factor 1 (HNF-1), N terminus Homeobox PF00046.27 001135726.2_26228001_1 - 1.7e-10 40.4 0.6 6.9e-10 38.5 0.6 2.1 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001135726.2_26228001_1 - 0.00047 19.9 0.6 0.0075 16.0 0.1 2.6 2 0 0 2 2 2 1 Homeobox KN domain HTH_37 PF13744.4 001135726.2_26228001_1 - 0.0017 18.1 0.3 0.0041 16.9 0.3 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.20 001135726.2_26228001_1 - 0.0094 15.9 0.1 0.024 14.6 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.5 001135726.2_26228001_1 - 0.043 13.8 0.1 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain DUF494 PF04361.11 001135726.2_26228001_1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF494) HTH_24 PF13412.4 001135726.2_26228001_1 - 0.08 12.4 0.0 0.2 11.1 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_31 PF13560.4 001135726.2_26228001_1 - 0.16 12.2 1.1 0.28 11.4 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain Pex14_N PF04695.11 001135726.2_26228001_1 - 0.99 10.0 4.6 0.61 10.7 2.0 1.9 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region LEDGF PF11467.6 008233.4_32925001_2 - 2.8e-28 97.9 1.9 4.7e-28 97.1 1.9 1.3 1 0 0 1 1 1 1 Lens epithelium-derived growth factor (LEDGF) PWWP PF00855.15 008233.4_32925001_2 - 9e-15 54.8 0.1 3.7e-14 52.8 0.1 2.1 1 0 0 1 1 1 1 PWWP domain Y_phosphatase PF00102.25 130435.4_26229001_2 - 2.9e-166 550.5 6.6 6.4e-84 281.1 0.4 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.18 130435.4_26229001_2 - 5.4e-10 39.1 0.2 0.00018 21.2 0.1 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 130435.4_26229001_2 - 7.2e-08 32.5 0.2 0.01 15.7 0.0 2.6 3 0 0 3 3 3 2 Tyrosine phosphatase family PTPlike_phytase PF14566.4 130435.4_26229001_2 - 4.5e-06 26.7 0.1 0.027 14.5 0.1 2.7 2 0 0 2 2 2 2 Inositol hexakisphosphate Y_phosphatase2 PF03162.11 130435.4_26229001_2 - 0.015 14.8 0.0 2 7.9 0.0 2.5 2 0 0 2 2 2 0 Tyrosine phosphatase family Laminin_G_2 PF02210.22 001346959.1_32929001_1 - 1.4e-22 80.4 0.1 2.3e-22 79.8 0.1 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.21 001346959.1_32929001_1 - 7.1e-09 35.8 0.0 1.5e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain Syndecan PF01034.18 001346959.1_32929001_1 - 3.2e-07 30.0 0.0 7e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Syndecan domain DUF202 PF02656.13 001346959.1_32929001_1 - 0.074 13.4 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) zf-C2H2 PF00096.24 001282999.2_26226001_1 - 1.1e-79 258.5 104.3 3.9e-07 30.0 0.4 16.0 16 0 0 16 16 15 15 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001282999.2_26226001_1 - 2.4e-77 252.0 80.5 3.3e-06 27.2 0.4 16.2 15 1 1 16 16 16 14 Zinc-finger double domain zf-C2H2_4 PF13894.4 001282999.2_26226001_1 - 5.6e-47 154.2 101.4 0.004 17.7 0.3 16.4 16 0 0 16 16 16 15 C2H2-type zinc finger KRAB PF01352.25 001282999.2_26226001_1 - 9.9e-25 85.8 0.1 1.7e-24 85.0 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 001282999.2_26226001_1 - 1.3e-13 50.8 33.5 4.1 7.7 0.0 13.8 14 0 0 14 14 14 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001282999.2_26226001_1 - 3.5e-09 36.2 88.8 0.024 14.5 1.6 15.0 14 1 0 14 14 14 6 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001282999.2_26226001_1 - 2.8e-08 33.6 61.9 0.03 14.3 0.8 10.7 3 2 9 13 13 13 6 Zinc ribbon domain zinc_ribbon_15 PF17032.3 001282999.2_26226001_1 - 7.9e-08 32.8 45.3 0.44 11.2 0.4 7.9 1 1 7 8 8 8 6 zinc-ribbon family ADK_lid PF05191.12 001282999.2_26226001_1 - 4.5e-06 26.5 50.4 0.033 14.1 0.5 10.5 5 2 6 11 11 11 5 Adenylate kinase, active site lid zf-C2H2_11 PF16622.3 001282999.2_26226001_1 - 1.5e-05 24.5 82.6 0.21 11.2 0.8 15.0 15 0 0 15 15 15 6 zinc-finger C2H2-type DUF3268 PF11672.6 001282999.2_26226001_1 - 0.0028 17.9 43.2 0.38 11.0 1.2 8.2 4 2 2 8 8 8 4 zinc-finger-containing domain Chordopox_RPO7 PF05864.10 001282999.2_26226001_1 - 0.013 15.6 28.6 24 5.1 0.7 10.3 10 1 1 11 11 11 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) zf-trcl PF13451.4 001282999.2_26226001_1 - 0.013 15.2 52.8 4.2 7.2 0.1 13.5 14 1 0 14 14 14 0 Probable zinc-ribbon domain BHD_1 PF10403.7 001282999.2_26226001_1 - 0.083 12.6 0.1 1.5 8.5 0.0 3.1 5 1 0 5 5 5 0 Rad4 beta-hairpin domain 1 zf-met PF12874.5 001282999.2_26226001_1 - 1.1 9.6 70.6 3.7 7.9 0.1 13.9 14 0 0 14 14 14 0 Zinc-finger of C2H2 type DUF2799 PF10973.6 001282999.2_26226001_2 - 0.34 11.2 3.7 0.75 10.1 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2799) Ig_2 PF13895.4 001313948.1_45725001_3 - 2.3e-35 120.7 13.8 4.4e-09 36.4 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin domain Ig_3 PF13927.4 001313948.1_45725001_3 - 2.6e-27 95.1 6.8 9.5e-06 26.0 0.2 5.6 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 001313948.1_45725001_3 - 1.5e-23 82.6 13.0 9.8e-09 35.1 0.2 5.5 5 1 0 5 5 5 4 Immunoglobulin domain I-set PF07679.14 001313948.1_45725001_3 - 7.5e-07 29.0 0.2 0.26 11.3 0.0 4.5 4 1 0 4 4 4 2 Immunoglobulin I-set domain V-set PF07686.15 001313948.1_45725001_3 - 2e-05 24.6 16.2 0.12 12.4 0.0 6.6 5 2 1 6 6 6 2 Immunoglobulin V-set domain Lep_receptor_Ig PF06328.9 001313948.1_45725001_3 - 0.018 15.0 0.2 12 5.8 0.0 3.6 3 0 0 3 3 3 0 Ig-like C2-type domain Izumo-Ig PF16706.3 001313948.1_45725001_3 - 0.037 13.9 0.1 15 5.5 0.0 3.5 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain Cadherin_C_2 PF16492.3 001313948.1_45725001_3 - 0.067 13.8 0.0 0.29 11.8 0.0 2.1 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal Adeno_E3_CR1 PF02440.13 001313948.1_45725001_3 - 0.074 12.7 5.8 8.8 6.1 0.0 3.8 4 0 0 4 4 4 0 Adenovirus E3 region protein CR1 EphA2_TM PF14575.4 001313948.1_45725001_3 - 0.097 13.4 0.0 0.44 11.3 0.0 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain KRAB PF01352.25 001329519.1_26228001_1 - 4.8e-25 86.8 1.3 8.6e-25 86.0 1.3 1.4 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 001329519.1_26228001_2 - 4e-165 529.5 153.2 7.4e-10 38.7 1.9 21.0 21 0 0 21 21 20 20 Zinc-finger double domain zf-C2H2 PF00096.24 001329519.1_26228001_2 - 1.7e-106 343.0 139.1 1.8e-06 27.9 0.6 21.1 21 0 0 21 21 20 19 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001329519.1_26228001_2 - 1.9e-46 152.5 138.7 0.011 16.4 0.4 21.1 21 0 0 21 21 20 19 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001329519.1_26228001_2 - 2e-31 107.5 64.9 0.059 13.6 0.2 19.2 19 0 0 19 19 19 11 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001329519.1_26228001_2 - 1.1e-29 101.7 115.7 0.00049 19.8 0.4 20.5 21 0 0 21 21 20 16 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001329519.1_26228001_2 - 5.7e-21 74.2 108.7 0.0045 16.9 3.5 12.9 4 3 9 15 15 15 13 Zinc ribbon domain XPA_N PF01286.16 001329519.1_26228001_2 - 5.4e-18 64.6 72.9 1.9 8.4 0.1 19.8 19 0 0 19 19 19 5 XPA protein N-terminal zinc_ribbon_15 PF17032.3 001329519.1_26228001_2 - 1.5e-07 31.9 82.9 0.53 10.9 0.8 10.4 2 1 7 11 11 11 9 zinc-ribbon family C1_4 PF07975.10 001329519.1_26228001_2 - 3.7e-07 30.2 82.4 0.036 14.2 1.9 12.4 2 2 10 15 15 15 7 TFIIH C1-like domain zf-trcl PF13451.4 001329519.1_26228001_2 - 2.5e-06 27.2 86.5 0.69 9.7 2.1 17.0 15 3 0 15 15 15 2 Probable zinc-ribbon domain BHD_1 PF10403.7 001329519.1_26228001_2 - 0.0028 17.3 11.2 38 4.1 0.0 8.9 7 2 1 8 8 8 0 Rad4 beta-hairpin domain 1 DUF3741 PF12552.6 001329519.1_26228001_2 - 0.024 14.5 16.3 1.1e+02 2.7 0.0 10.9 14 1 1 15 15 14 0 Protein of unknown function (DUF3741) Raffinose_syn PF05691.10 001329519.1_26228001_2 - 3.2 5.3 13.9 4 5.0 0.1 6.0 2 2 7 9 9 9 0 Raffinose synthase or seed imbibition protein Sip1 FYVE PF01363.19 001329519.1_26228001_2 - 5.9 7.0 84.0 1.6e+04 -6.8 22.0 9.9 1 1 1 2 2 0 0 FYVE zinc finger Baculo_LEF-11 PF06385.10 001329519.1_26228001_3 - 0.0043 17.4 14.5 0.53 10.7 0.1 6.9 5 2 3 8 8 8 1 Baculovirus LEF-11 protein TGT PF01702.16 001329519.1_26228001_3 - 2.1 7.9 4.4 6.3 6.4 0.1 3.1 2 1 1 3 3 3 0 Queuine tRNA-ribosyltransferase IL10 PF00726.15 001305896.1_29722001_2 - 7.4e-104 344.4 0.6 8.7e-104 344.2 0.6 1.0 1 0 0 1 1 1 1 Interleukin 10 IL22 PF14565.4 001305896.1_29722001_2 - 3.6e-07 30.4 0.3 7e-07 29.5 0.3 1.4 1 1 1 2 2 2 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor ALIX_LYPXL_bnd PF13949.4 001305896.1_29722001_2 - 0.042 13.0 0.1 0.067 12.3 0.1 1.3 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV CLZ PF16526.3 001305896.1_29722001_2 - 0.076 13.2 1.3 0.32 11.3 0.1 2.4 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Stanniocalcin PF03298.11 001305923.1_29724001_3 - 8.4e-92 305.9 5.2 1.1e-91 305.5 5.2 1.1 1 0 0 1 1 1 1 Stanniocalcin family Calc_CGRP_IAPP PF00214.17 001081854.3_21022001_1 - 1.3e-34 119.0 0.0 1.9e-34 118.5 0.0 1.3 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family Oxidored-like PF09791.7 001304999.1_26224001_1 - 1.6e-10 40.3 1.3 4.1e-10 39.0 1.3 1.6 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal DUF3331 PF11811.6 001304999.1_26224001_3 - 0.3 10.8 1.1 0.54 10.0 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3331) FAM27 PF15832.3 001324204.1_26226001_2 - 0.29 11.6 5.4 0.54 10.7 5.4 1.4 1 0 0 1 1 1 0 FAM27 D and E protein family TNFR_c6 PF00020.16 001324204.1_26226001_3 - 0.00031 21.0 3.4 0.00031 21.0 3.4 2.3 2 0 0 2 2 2 1 TNFR/NGFR cysteine-rich region Ion_trans PF00520.29 016179.3_26229001_1 - 5.2e-32 110.9 15.7 9.7e-32 110.0 15.7 1.4 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.9 016179.3_26229001_1 - 1e-27 96.0 0.8 2e-27 95.0 0.8 1.6 1 0 0 1 1 1 1 Transient receptor ion channel II Ank_2 PF12796.5 016179.3_26229001_1 - 1.5e-08 34.9 0.5 0.00014 22.2 0.3 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 016179.3_26229001_1 - 1.6e-08 34.8 0.0 0.002 18.5 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 016179.3_26229001_1 - 3.1e-05 23.9 1.1 0.52 10.9 0.1 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.28 016179.3_26229001_1 - 0.00098 19.3 0.5 2.3 8.7 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 016179.3_26229001_1 - 0.0081 16.4 0.0 11 6.5 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) TLE_N PF03920.13 001351550.1_26229001_2 - 2.1e-51 173.3 18.6 4e-42 143.2 3.8 2.3 1 1 1 2 2 2 2 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.30 001351550.1_26229001_2 - 4.5e-15 55.6 17.7 0.035 14.8 0.8 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001351550.1_26229001_2 - 9.8e-07 28.9 0.0 0.34 11.1 0.0 4.0 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain HALZ PF02183.16 001351550.1_26229001_2 - 0.077 13.1 0.3 0.17 12.0 0.3 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper Rap_GAP PF02145.13 001346248.1_26229001_3 - 1.6e-47 161.3 0.0 4.3e-47 160.0 0.0 1.7 1 0 0 1 1 1 1 Rap/ran-GAP Exo_endo_phos PF03372.21 001357143.1_32923001_1 - 0.00042 20.4 0.0 0.0006 19.9 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Runt PF00853.17 001278483.1_45729001_1 - 6.1e-73 242.4 0.1 9.2e-73 241.8 0.1 1.3 1 0 0 1 1 1 1 Runt domain RunxI PF08504.9 001278483.1_45729001_1 - 1.3e-37 128.3 5.7 1.3e-37 128.3 5.7 2.5 2 0 0 2 2 1 1 Runx inhibition domain Suf PF05843.12 001278483.1_45729001_1 - 0.0031 17.4 7.1 0.0057 16.5 7.1 1.3 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) DUF2722 PF10846.6 001278483.1_45729001_1 - 0.0047 15.8 18.5 0.0082 15.0 18.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF2828 PF11443.6 001278483.1_45729001_1 - 0.02 12.9 1.9 0.029 12.4 1.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) EPL1 PF10513.7 001278483.1_45729001_1 - 0.054 13.7 4.5 0.097 12.9 4.5 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like eIF-3_zeta PF05091.10 001278483.1_45729001_1 - 0.11 11.4 6.1 0.15 10.8 6.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Plasmodium_Vir PF05795.9 001278483.1_45729001_1 - 0.14 11.4 1.9 0.18 11.0 0.9 1.6 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Trp_oprn_chp PF09534.8 001278483.1_45729001_1 - 0.18 11.4 5.9 0.3 10.7 5.9 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) SpoIIP PF07454.9 001278483.1_45729001_1 - 0.3 10.4 5.0 0.48 9.7 5.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TFIIA PF03153.11 001278483.1_45729001_1 - 0.51 10.1 29.0 0.036 13.9 23.4 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Ribosomal_60s PF00428.17 001278483.1_45729001_1 - 1 9.9 7.5 53 4.3 10.9 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein FlaG PF03646.13 001278483.1_45729001_1 - 1.3 9.0 11.9 2.6 8.1 11.9 1.4 1 0 0 1 1 1 0 FlaG protein GREB1 PF15782.3 001278483.1_45729001_1 - 1.4 5.8 8.4 1.9 5.3 8.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TERB2 PF15101.4 001278483.1_45729001_1 - 1.7 8.6 12.7 2.9 7.8 12.7 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Presenilin PF01080.15 001278483.1_45729001_1 - 2.7 6.5 8.8 4.3 5.9 8.8 1.2 1 0 0 1 1 1 0 Presenilin PIH1 PF08190.10 001278483.1_45729001_1 - 3 7.5 12.6 4.6 6.8 12.6 1.2 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 VID27 PF08553.8 001278483.1_45729001_1 - 4.2 5.6 7.9 5.9 5.2 7.9 1.0 1 0 0 1 1 1 0 VID27 cytoplasmic protein PAT1 PF09770.7 001278483.1_45729001_1 - 4.2 5.4 16.6 6.2 4.8 16.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RR_TM4-6 PF06459.10 001278483.1_45729001_1 - 5.2 6.7 7.5 8.1 6.1 7.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3391 PF11871.6 001278483.1_45729001_1 - 5.9 7.3 11.3 11 6.4 11.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) UPF0560 PF10577.7 001278483.1_45729001_1 - 8.7 4.6 15.4 13 4.0 15.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF4614 PF15391.4 001278483.1_45729001_2 - 1.6 8.5 13.8 2.7 7.8 13.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) SR-25 PF10500.7 001278483.1_45729001_2 - 2.2 7.7 29.0 3.4 7.1 29.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4525 PF15027.4 001291069.1_32929001_1 - 2.4 7.8 5.9 0.77 9.4 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4525) FlaC_arch PF05377.9 001291069.1_32929001_1 - 4.4 7.6 7.6 2.2 8.6 2.2 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) TGFb_propeptide PF00688.16 214015.2_49826001_2 - 2.7e-37 128.7 0.0 3.5e-37 128.4 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 214015.2_49826001_2 - 5.9e-22 78.4 1.6 1.2e-21 77.4 1.6 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain HMG_box_5 PF14887.4 001105723.3_45729001_1 - 9.1e-53 176.1 7.3 9.1e-53 176.1 7.3 4.9 4 1 1 5 5 5 2 HMG (high mobility group) box 5 HMG_box PF00505.17 001105723.3_45729001_1 - 3.8e-44 148.8 51.9 1.5e-17 63.7 7.5 6.3 5 1 1 6 6 6 5 HMG (high mobility group) box HMG_box_2 PF09011.8 001105723.3_45729001_1 - 8.7e-24 83.8 43.9 5.9e-08 33.1 0.2 6.1 5 1 1 6 6 6 5 HMG-box domain DUF4473 PF14747.4 001105723.3_45729001_1 - 0.0039 17.6 0.3 0.0039 17.6 0.3 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4473) IRK PF01007.18 031602.2_45723001_3 - 6.2e-135 449.3 0.0 7.8e-135 448.9 0.0 1.0 1 0 0 1 1 1 1 Inward rectifier potassium channel DUF2182 PF09948.7 031602.2_45723001_3 - 0.05 13.4 1.0 0.09 12.5 1.0 1.3 1 0 0 1 1 1 0 Predicted metal-binding integral membrane protein (DUF2182) Ion_trans_2 PF07885.14 031602.2_45723001_3 - 0.06 13.2 3.5 0.16 11.9 3.5 1.8 1 0 0 1 1 1 0 Ion channel AC_N PF16214.3 012821.4_45729001_1 - 4.7e-121 404.7 3.7 9.3e-121 403.7 0.0 2.2 2 0 0 2 2 2 1 Adenylyl cyclase N-terminal extracellular and transmembrane region Guanylate_cyc PF00211.18 012821.4_45729001_1 - 1.5e-119 396.1 1.8 6.4e-61 205.0 0.4 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF1053 PF06327.12 012821.4_45729001_1 - 9.6e-15 54.9 0.3 2e-14 53.8 0.3 1.5 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) HNOBA PF07701.12 012821.4_45729001_1 - 0.015 14.7 0.1 0.98 8.7 0.0 2.4 2 0 0 2 2 2 0 Heme NO binding associated DUF5134 PF17197.2 012821.4_45729001_1 - 0.44 10.3 8.1 1.6 8.5 8.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5134) MENTAL PF10457.7 012821.4_45729001_1 - 1.3 8.7 4.2 3.5 7.3 4.2 1.6 1 0 0 1 1 1 0 Cholesterol-capturing domain Shisa PF13908.4 012821.4_45729001_1 - 4 7.5 5.4 3.6 7.6 3.2 2.1 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF2842 PF11003.6 012821.4_45729001_2 - 0.038 14.1 0.3 0.086 13.0 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2842) PAX PF00292.16 001244202.2_32929001_2 - 3.1e-71 237.0 0.8 5.4e-71 236.2 0.8 1.4 1 0 0 1 1 1 1 'Paired box' domain Homeobox PF00046.27 001244202.2_32929001_2 - 2e-22 78.6 4.5 4.3e-22 77.6 4.5 1.6 1 0 0 1 1 1 1 Homeobox domain HTH_23 PF13384.4 001244202.2_32929001_2 - 0.007 16.0 0.2 0.034 13.8 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_IS1 PF12759.5 001244202.2_32929001_2 - 0.017 14.6 0.0 0.052 13.0 0.0 1.8 1 0 0 1 1 1 0 InsA C-terminal domain EF_assoc_2 PF08356.10 001352277.1_26226001_1 - 1.6e-32 111.2 0.0 2.7e-32 110.5 0.0 1.4 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.10 001352277.1_26226001_1 - 7.7e-23 79.8 0.0 5.7e-22 77.0 0.0 2.2 2 0 0 2 2 2 1 EF hand associated Ras PF00071.20 001352277.1_26226001_1 - 1.8e-14 53.6 0.0 0.00049 19.6 0.0 3.6 2 2 1 3 3 3 3 Ras family Roc PF08477.11 001352277.1_26226001_1 - 5.8e-07 29.6 0.0 0.005 16.9 0.0 3.5 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase EF-hand_7 PF13499.4 001352277.1_26226001_1 - 1.3e-05 25.4 0.0 0.069 13.5 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 001352277.1_26226001_1 - 0.00015 20.9 0.0 0.015 14.6 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 001352277.1_26226001_1 - 0.00016 21.2 0.1 0.0031 17.2 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain AAA_16 PF13191.4 001352277.1_26226001_1 - 0.00028 21.2 0.2 0.79 9.9 0.0 2.6 2 1 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.21 001352277.1_26226001_1 - 0.0017 18.3 0.0 2.1 8.3 0.0 2.6 2 1 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.21 001352277.1_26226001_1 - 0.0039 17.1 0.0 1.2 9.0 0.0 2.2 2 0 0 2 2 2 1 Dynamin family AAA_22 PF13401.4 001352277.1_26226001_1 - 0.019 15.1 0.0 6.2 7.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Arf PF00025.19 001352277.1_26226001_1 - 0.026 13.9 0.0 0.85 8.9 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family DUF258 PF03193.14 001352277.1_26226001_1 - 0.027 14.2 0.0 19 5.0 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function, DUF258 AAA_14 PF13173.4 001352277.1_26226001_1 - 0.053 13.4 0.0 9.4 6.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.25 001352277.1_26226001_1 - 0.08 13.3 0.0 8.8 6.7 0.0 2.3 2 0 0 2 2 2 0 ABC transporter SPARC_Ca_bdg PF10591.7 001352277.1_26226001_1 - 0.089 13.0 0.0 10 6.4 0.0 2.3 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Septin PF00735.16 001352277.1_26226001_1 - 0.11 11.5 0.0 9 5.3 0.0 2.2 2 0 0 2 2 2 0 Septin EF-hand_5 PF13202.4 001352277.1_26226001_1 - 0.19 11.2 0.0 0.39 10.2 0.0 1.6 1 0 0 1 1 1 0 EF hand Piezo_RRas_bdg PF12166.6 001077200.2_45729001_3 - 1.3e-154 515.4 0.0 2e-154 514.8 0.0 1.3 1 0 0 1 1 1 1 Piezo non-specific cation channel, R-Ras-binding domain PIEZO PF15917.3 001077200.2_45729001_3 - 1.5e-95 318.8 0.2 3e-95 317.9 0.2 1.5 1 0 0 1 1 1 1 Piezo 4_1_CTD PF05902.11 001350314.1_26228001_3 - 2.8e-43 146.3 4.5 2.8e-43 146.3 4.5 2.0 2 0 0 2 2 2 1 4.1 protein C-terminal domain (CTD) FERM_C PF09380.8 001350314.1_26228001_3 - 8.7e-24 83.6 0.0 1.8e-23 82.6 0.0 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.8 001350314.1_26228001_3 - 1.1e-20 73.2 0.1 3.2e-20 71.7 0.1 1.9 1 0 0 1 1 1 1 FERM N-terminal domain FA PF08736.9 001350314.1_26228001_3 - 2e-18 66.1 5.0 2e-18 66.1 5.0 2.1 2 0 0 2 2 2 1 FERM adjacent (FA) FERM_M PF00373.16 001350314.1_26228001_3 - 2.3e-18 66.6 0.0 2.3e-18 66.6 0.0 2.8 2 1 0 2 2 2 1 FERM central domain LRR_8 PF13855.4 001113039.2_49828001_3 - 3.4e-50 167.5 61.4 2.5e-12 46.3 1.0 10.2 6 1 4 10 10 10 10 Leucine rich repeat TIR PF01582.18 001113039.2_49828001_3 - 1.1e-32 113.1 0.2 1.8e-32 112.4 0.2 1.4 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.5 001113039.2_49828001_3 - 1.3e-26 91.9 53.7 1.2e-06 28.5 1.3 10.4 8 2 0 9 9 9 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001113039.2_49828001_3 - 2.6e-09 36.7 19.0 0.00042 19.7 0.1 5.3 2 2 2 5 5 5 4 Leucine-rich repeat LRR_1 PF00560.31 001113039.2_49828001_3 - 7.8e-09 34.6 56.9 0.42 11.1 0.6 15.2 16 0 0 16 16 16 6 Leucine Rich Repeat TIR_2 PF13676.4 001113039.2_49828001_3 - 1e-08 35.3 0.1 1.8e-08 34.5 0.1 1.4 1 0 0 1 1 1 1 TIR domain DUF1863 PF08937.9 001113039.2_49828001_3 - 0.00018 21.7 0.4 0.0006 20.0 0.4 1.8 1 1 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) LRR_6 PF13516.4 001113039.2_49828001_3 - 0.092 12.7 55.7 0.71 9.9 0.1 12.9 15 0 0 15 15 15 0 Leucine Rich repeat zf-H2C2_2 PF13465.4 001080951.2_26227001_3 - 4.9e-12 45.6 52.9 7.5e-05 22.9 3.7 8.8 8 0 0 8 8 8 5 Zinc-finger double domain zf-C2H2 PF00096.24 001080951.2_26227001_3 - 1.7e-11 43.8 65.9 3e-05 24.1 0.5 7.5 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001080951.2_26227001_3 - 3.8e-11 42.7 64.2 0.0052 17.4 0.4 8.7 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001080951.2_26227001_3 - 0.0027 17.8 24.5 0.5 10.6 4.5 6.7 5 1 1 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001080951.2_26227001_3 - 0.14 12.5 26.6 0.022 15.0 4.6 5.4 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 001080951.2_26227001_3 - 1 9.1 29.8 1.5 8.6 2.0 6.1 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-C2H2_8 PF15909.3 001080951.2_26227001_3 - 2.4 8.4 22.1 1.9 8.7 5.2 3.4 1 1 2 3 3 3 0 C2H2-type zinc ribbon RGS PF00615.17 001282773.2_26225001_2 - 3.6e-35 120.6 0.1 8.7e-35 119.4 0.1 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain G-gamma PF00631.20 001282773.2_26225001_2 - 9.4e-14 51.0 0.1 9.4e-14 51.0 0.1 1.9 2 0 0 2 2 2 1 GGL domain DEP PF00610.19 001282773.2_26225001_2 - 1.2e-07 31.5 0.0 3.8e-07 29.9 0.0 1.8 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RGS-like PF09128.9 001282773.2_26225001_2 - 0.0057 16.3 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain DUF1003 PF06210.9 001282773.2_26225001_2 - 0.013 15.5 2.8 0.39 10.7 1.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) Ig_2 PF13895.4 001289023.2_26226001_2 - 4.3e-08 33.2 0.0 7.8e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001289023.2_26226001_2 - 6.7e-05 23.3 0.0 0.00013 22.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain DUF4448 PF14610.4 001289023.2_26226001_2 - 0.025 14.3 0.0 0.038 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Cadherin_C_2 PF16492.3 001289023.2_26226001_2 - 0.076 13.7 0.0 0.18 12.5 0.0 1.5 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal OAD_gamma PF04277.11 001289023.2_26226001_2 - 0.15 12.5 0.0 0.32 11.5 0.0 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain PAX PF00292.16 001244201.2_32928001_1 - 2.7e-71 237.2 0.8 4.5e-71 236.5 0.8 1.4 1 0 0 1 1 1 1 'Paired box' domain Homeobox PF00046.27 001244201.2_32928001_1 - 1.7e-22 78.9 4.5 3.6e-22 77.8 4.5 1.6 1 0 0 1 1 1 1 Homeobox domain HTH_32 PF13565.4 001244201.2_32928001_1 - 0.00025 21.5 0.9 0.012 16.0 0.0 3.1 3 0 0 3 3 3 1 Homeodomain-like domain HTH_23 PF13384.4 001244201.2_32928001_1 - 0.01 15.5 0.0 0.029 14.0 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_Tnp_IS1 PF12759.5 001244201.2_32928001_1 - 0.017 14.6 0.0 0.045 13.2 0.0 1.6 2 0 0 2 2 2 0 InsA C-terminal domain PFK PF00365.18 001081922.2_21026001_1 - 5.3e-200 662.3 6.6 5.7e-109 363.7 0.9 2.1 2 0 0 2 2 2 2 Phosphofructokinase 7tm_2 PF00002.22 030999.4_45726001_3 - 7.6e-78 261.1 19.6 9.7e-78 260.7 19.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 030999.4_45726001_3 - 2.6e-16 59.5 1.1 5.2e-16 58.6 1.1 1.5 1 0 0 1 1 1 1 Hormone receptor domain Tubulin PF00091.23 001315710.1_49824001_1 - 7.5e-69 231.7 0.0 1e-68 231.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001315710.1_49824001_1 - 2.7e-51 172.9 0.0 4.5e-51 172.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 001315710.1_49824001_1 - 0.0018 17.8 0.0 0.0035 16.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain WD40 PF00400.30 172994.3_32929001_3 - 0.00064 20.3 10.0 6.1 7.8 0.1 6.1 7 0 0 7 7 7 3 WD domain, G-beta repeat MutL_C PF08676.9 000535.6_26229001_1 - 1.4e-29 102.6 0.0 2.9e-29 101.6 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.17 000535.6_26229001_1 - 5.4e-23 80.8 0.1 3.4e-22 78.2 0.0 2.2 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.4 000535.6_26229001_1 - 1.6e-11 44.1 0.0 3e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.24 000535.6_26229001_1 - 2.2e-05 24.8 0.0 5.3e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TACC PF05010.12 001352797.1_26229001_3 - 6.7e-80 267.5 34.4 9.2e-80 267.0 34.4 1.2 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC) Pkinase PF00069.23 001322230.1_26229001_1 - 1.6e-76 257.0 0.3 1.9e-72 243.7 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 001322230.1_26229001_1 - 1.6e-31 109.4 0.0 2.5e-31 108.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.22 001322230.1_26229001_1 - 8.8e-09 35.8 0.5 2e-08 34.6 0.5 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kdo PF06293.12 001322230.1_26229001_1 - 3.7e-08 32.8 0.1 6.1e-08 32.1 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001322230.1_26229001_1 - 3.9e-05 23.6 0.0 0.00031 20.6 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.4 001322230.1_26229001_1 - 7.1e-05 22.1 0.0 0.00017 20.8 0.0 1.6 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.20 001322230.1_26229001_1 - 0.00045 19.7 0.2 0.0008 18.9 0.2 1.3 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.18 001322230.1_26229001_1 - 0.044 13.2 0.7 0.1 12.0 0.1 1.7 2 0 0 2 2 2 0 Choline/ethanolamine kinase Pkinase PF00069.23 001322230.1_26229001_3 - 1.8e-59 201.1 0.2 2.5e-59 200.6 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001322230.1_26229001_3 - 1.7e-29 102.8 0.1 2.4e-29 102.3 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001322230.1_26229001_3 - 0.0023 17.1 0.0 0.0039 16.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.4 001322230.1_26229001_3 - 0.0061 16.1 0.2 1.9 7.9 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Fer4_4 PF12800.5 001082261.1_37923001_1 - 5.6 7.6 8.9 0.17 12.4 0.6 3.0 3 0 0 3 3 3 0 4Fe-4S binding domain ATP-gua_Ptrans PF00217.17 001082261.1_37923001_3 - 3.6e-98 327.9 0.0 4.6e-98 327.6 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 001082261.1_37923001_3 - 4.3e-32 110.2 0.0 7.1e-32 109.5 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain ERCC3_RAD25_C PF16203.3 001132325.1_43526001_1 - 2.3e-125 416.6 1.9 3.8e-125 415.9 1.9 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.4 001132325.1_43526001_1 - 1.5e-38 131.7 0.0 4.2e-38 130.2 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 001132325.1_43526001_1 - 1.8e-15 57.2 0.0 4.2e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.29 001132325.1_43526001_1 - 3e-10 40.3 0.1 6.9e-10 39.2 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.21 001132325.1_43526001_1 - 0.0023 16.6 0.0 0.0028 16.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.27 001132325.1_43526001_1 - 0.0065 16.1 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2748 PF10871.6 001132325.1_43526001_1 - 0.015 13.8 0.0 1.1 7.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2748) ATP-gua_Ptrans PF00217.17 001082239.1_37923001_1 - 8.1e-95 316.9 0.0 1e-94 316.6 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 001082239.1_37923001_1 - 1.5e-35 121.2 0.0 3e-35 120.3 0.0 1.5 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain PPI_Ypi1 PF07491.9 001071817.1_39721001_1 - 1e-21 76.3 4.0 1.6e-21 75.8 4.0 1.2 1 0 0 1 1 1 1 Protein phosphatase inhibitor DUF4696 PF15767.3 001244542.1_49827001_3 - 2.4e-263 874.9 56.9 2.9e-263 874.6 56.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4696) BUD22 PF09073.8 001244542.1_49827001_3 - 0.0012 18.1 2.1 0.0024 17.2 2.1 1.6 1 0 0 1 1 1 1 BUD22 RNA_polI_A34 PF08208.9 001244542.1_49827001_3 - 0.012 15.6 0.1 0.041 13.8 0.1 1.9 1 1 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Plasmodium_Vir PF05795.9 001244542.1_49827001_3 - 0.063 12.6 0.0 0.15 11.3 0.0 1.7 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Sigma70_ner PF04546.11 001244542.1_49827001_3 - 0.21 11.3 8.4 0.49 10.1 8.4 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region SDA1 PF05285.10 001244542.1_49827001_3 - 0.25 10.6 10.6 0.5 9.6 10.6 1.4 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.10 001244542.1_49827001_3 - 0.4 8.7 13.7 0.78 7.8 13.7 1.4 1 0 0 1 1 1 0 Nop14-like family FAM176 PF14851.4 001244542.1_49827001_3 - 0.78 9.3 7.1 6.6 6.3 7.8 2.2 2 0 0 2 2 2 0 FAM176 family TFIIA PF03153.11 001244542.1_49827001_3 - 1.1 9.0 12.9 2.2 8.1 12.9 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RNA_pol_3_Rpc31 PF11705.6 001244542.1_49827001_3 - 1.6 8.8 19.6 4.5 7.3 19.6 1.7 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CobT PF06213.10 001244542.1_49827001_3 - 3.2 6.9 13.1 6.9 5.8 13.1 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NOA36 PF06524.10 001244542.1_49827001_3 - 3.7 6.7 18.2 6.4 5.9 18.2 1.3 1 0 0 1 1 1 0 NOA36 protein Paf1 PF03985.11 001244542.1_49827001_3 - 5.7 5.7 12.0 11 4.8 12.0 1.4 1 0 0 1 1 1 0 Paf1 Cwf_Cwc_15 PF04889.10 001244542.1_49827001_3 - 7 6.2 13.4 14 5.2 13.4 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.11 001244542.1_49827001_3 - 7.3 4.4 21.4 11 3.8 21.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF3449 PF11931.6 001244542.1_49827001_3 - 9.3 5.9 7.9 0.87 9.2 2.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) CAP_N PF01213.17 001243575.1_49823001_1 - 5.5 6.2 7.4 9.2 5.5 7.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal ATP-gua_Ptrans PF00217.17 001243575.1_49823001_3 - 8e-98 326.8 0.0 9.8e-98 326.5 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 001243575.1_49823001_3 - 1.8e-34 117.8 0.0 2.9e-34 117.1 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain Macoilin PF09726.7 001355499.1_32929001_1 - 2.2e-44 152.0 5.0 3e-44 151.6 5.0 1.1 1 0 0 1 1 1 1 Transmembrane protein Macoilin PF09726.7 001355499.1_32929001_2 - 2.2e-278 925.3 21.1 2.9e-278 924.9 21.1 1.0 1 0 0 1 1 1 1 Transmembrane protein Reo_sigmaC PF04582.10 001355499.1_32929001_2 - 0.023 14.0 7.8 0.25 10.6 0.7 2.2 2 0 0 2 2 2 0 Reovirus sigma C capsid protein GLE1 PF07817.11 001355499.1_32929001_2 - 2.2 7.3 12.9 1.3 8.0 0.1 2.2 2 0 0 2 2 2 0 GLE1-like protein FPP PF05911.9 001355499.1_32929001_2 - 3.6 5.6 49.5 1.2 7.2 27.5 2.3 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil rRNA_proc-arch PF13234.4 028151.2_32927001_3 - 8.7e-92 307.7 1.5 1.4e-91 306.9 1.5 1.4 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.10 028151.2_32927001_3 - 1.1e-58 197.4 0.8 2.1e-58 196.5 0.8 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.27 028151.2_32927001_3 - 2.8e-17 62.9 0.0 6.6e-17 61.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 028151.2_32927001_3 - 1.9e-07 31.3 0.0 1.8e-06 28.2 0.0 2.6 1 1 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.4 028151.2_32927001_3 - 0.019 15.2 0.1 0.067 13.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.4 028151.2_32927001_3 - 0.039 14.1 0.0 0.18 11.9 0.0 2.2 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.18 028151.2_32927001_3 - 0.051 12.5 0.0 0.19 10.6 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein Sec3-PIP2_bind PF15277.4 001351575.1_26222001_2 - 1.5e-18 66.6 0.4 2.4e-18 65.9 0.4 1.3 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH PPI_Ypi1 PF07491.9 001047136.1_29621001_1 - 1e-21 76.3 4.0 1.6e-21 75.8 4.0 1.2 1 0 0 1 1 1 1 Protein phosphatase inhibitor OB_NTP_bind PF07717.14 001042380.1_39727001_1 - 2.7e-22 78.9 0.0 1e-21 77.0 0.0 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 001042380.1_39727001_1 - 1.9e-20 73.0 0.0 1.9e-20 73.0 0.0 3.4 2 1 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.29 001042380.1_39727001_1 - 4.3e-12 46.2 0.0 1.1e-11 44.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 001042380.1_39727001_1 - 5.8e-07 29.3 0.0 1.9e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_30 PF13604.4 001042380.1_39727001_1 - 3e-05 23.7 0.5 8.8e-05 22.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.4 001042380.1_39727001_1 - 0.0012 18.9 0.0 0.0052 16.9 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.4 001042380.1_39727001_1 - 0.0092 16.2 0.0 0.021 15.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.18 001042380.1_39727001_1 - 0.01 14.8 0.0 0.039 12.9 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein SecA_DEAD PF07517.12 001042380.1_39727001_1 - 0.014 14.5 0.3 0.043 13.0 0.0 1.9 2 0 0 2 2 2 0 SecA DEAD-like domain SRP54 PF00448.20 001042380.1_39727001_1 - 0.035 13.6 0.1 0.13 11.7 0.1 1.9 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain Flavi_DEAD PF07652.12 001042380.1_39727001_1 - 0.042 13.7 0.0 0.084 12.7 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_23 PF13476.4 001042380.1_39727001_1 - 1.6 9.1 0.0 1.6 9.1 0.0 3.1 2 1 1 3 3 1 0 AAA domain ATP-gua_Ptrans PF00217.17 001129949.1_49824001_3 - 1.2e-94 316.4 0.0 1.5e-94 316.1 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 001129949.1_49824001_3 - 1.3e-34 118.3 0.0 2.6e-34 117.3 0.0 1.5 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain TGFb_propeptide PF00688.16 001285737.1_09023001_1 - 4.3e-31 108.4 0.0 6.4e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001285737.1_09023001_1 - 1.9e-28 99.3 0.7 5.9e-28 97.7 0.7 1.9 1 0 0 1 1 1 1 Transforming growth factor beta like domain 7tm_1 PF00001.19 001172729.1_09924001_2 - 4.9e-57 193.1 20.6 6.9e-57 192.6 20.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001172729.1_09924001_2 - 2.7e-09 36.6 20.1 3.6e-09 36.2 20.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001172729.1_09924001_2 - 2e-05 24.4 16.3 4.1e-05 23.3 16.3 1.5 1 1 0 1 1 1 1 Olfactory receptor DUF4381 PF14316.4 001172729.1_09924001_2 - 0.29 11.2 3.4 0.75 9.9 3.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) PDGF PF00341.15 001287111.1_45727001_1 - 4.4e-26 90.9 6.7 8.1e-26 90.0 6.7 1.5 1 0 0 1 1 1 1 PDGF/VEGF domain TGF_beta PF00019.18 019139.1_45722001_2 - 1.5e-11 45.0 0.2 2.2e-11 44.4 0.2 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain COesterase PF00135.26 009375.2_32929001_2 - 2e-133 445.9 0.0 2.7e-133 445.5 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Thyroglobulin_1 PF00086.16 009375.2_32929001_2 - 5.8e-124 403.8 99.8 8.5e-15 54.1 4.2 12.7 12 0 0 12 12 12 12 Thyroglobulin type-1 repeat Ephrin_rec_like PF07699.11 009375.2_32929001_2 - 5.8e-14 51.5 12.9 2e-13 49.8 8.3 3.1 1 1 1 2 2 2 2 Putative ephrin-receptor like Abhydrolase_3 PF07859.11 009375.2_32929001_2 - 0.0072 16.0 0.1 0.015 15.0 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold KdpC PF02669.13 009375.2_32929001_2 - 0.06 13.1 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 K+-transporting ATPase, c chain Peptidase_M28 PF04389.15 001128148.2_26229001_2 - 1.5e-11 44.3 0.0 2e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.13 001128148.2_26229001_2 - 1.4e-10 41.2 0.2 2.5e-09 37.2 0.0 2.6 3 0 0 3 3 3 1 Transferrin receptor-like dimerisation domain PA PF02225.20 001128148.2_26229001_2 - 8.4e-10 38.5 0.0 1.8e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 PA domain Trypsin PF00089.24 139125.3_26229001_1 - 2.3e-57 194.2 0.1 5.8e-57 192.9 0.0 1.8 2 0 0 2 2 2 1 Trypsin CUB PF00431.18 139125.3_26229001_1 - 5e-52 174.8 0.2 5e-31 107.2 0.0 2.4 2 0 0 2 2 2 2 CUB domain Sushi PF00084.18 139125.3_26229001_1 - 2.8e-15 56.5 5.7 3.1e-10 40.4 0.5 3.4 4 0 0 4 4 4 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.4 139125.3_26229001_1 - 1.4e-08 34.8 11.4 1.1e-07 31.9 9.0 3.0 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site Trypsin_2 PF13365.4 139125.3_26229001_1 - 2.2e-05 25.2 0.1 3.9e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain EGF_CA PF07645.13 139125.3_26229001_1 - 5.2e-05 23.2 9.4 5.2e-05 23.2 9.4 3.0 3 0 0 3 3 3 1 Calcium-binding EGF domain cEGF PF12662.5 139125.3_26229001_1 - 0.0019 18.0 5.4 0.007 16.1 3.8 2.8 2 0 0 2 2 2 1 Complement Clr-like EGF-like CUB_2 PF02408.18 139125.3_26229001_1 - 0.0065 16.1 0.2 2.3 7.8 0.0 2.6 2 0 0 2 2 2 2 CUB-like domain TGFb_propeptide PF00688.16 001109821.1_37923001_1 - 2.3e-31 109.3 0.0 2.9e-31 108.9 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001109821.1_37923001_1 - 2.1e-28 99.1 1.1 6e-28 97.7 1.1 1.8 1 0 0 1 1 1 1 Transforming growth factor beta like domain Bcl-2 PF00452.17 001317921.1_26226001_3 - 1e-33 115.8 0.1 1.7e-33 115.1 0.1 1.4 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family BH4 PF02180.15 001317921.1_26226001_3 - 7.2e-14 51.1 0.3 1.3e-13 50.3 0.3 1.4 1 0 0 1 1 1 1 Bcl-2 homology region 4 Bcl-2_3 PF15286.4 001317921.1_26226001_3 - 0.023 15.2 0.1 0.2 12.2 0.0 2.0 2 0 0 2 2 2 0 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like BCMA-Tall_bind PF09257.8 001192.2_26222001_3 - 2.9e-22 78.3 10.3 8.9e-22 76.7 10.3 1.9 1 0 0 1 1 1 1 BCMA, TALL-1 binding TACI-CRD2 PF09305.8 001192.2_26222001_3 - 0.0038 17.1 6.2 0.0097 15.8 6.2 1.7 1 0 0 1 1 1 1 TACI, cysteine-rich domain DUF4064 PF13273.4 001192.2_26222001_3 - 0.063 13.5 0.0 0.097 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) AMP-binding PF00501.26 012820.1_45728001_2 - 5.6e-109 364.4 0.0 6.9e-109 364.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 012820.1_45728001_2 - 0.00015 22.5 0.0 0.00031 21.5 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Sulfotransfer_1 PF00685.25 021615.4_26229001_1 - 3.7e-20 72.4 0.0 5.1e-20 71.9 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 021615.4_26229001_1 - 1.2e-12 48.6 0.0 1.4e-11 45.1 0.0 2.3 1 1 0 1 1 1 1 Sulfotransferase family PDGF PF00341.15 001287112.1_45727001_1 - 4.4e-26 90.9 6.7 8.1e-26 90.0 6.7 1.5 1 0 0 1 1 1 1 PDGF/VEGF domain Pkinase PF00069.23 012776.1_45726001_3 - 1.5e-70 237.4 0.0 4.6e-70 235.9 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 012776.1_45726001_3 - 3.4e-27 95.2 0.0 5e-27 94.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.17 012776.1_45726001_3 - 1.3e-17 64.0 3.2 3.2e-17 62.7 3.2 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain PH PF00169.27 012776.1_45726001_3 - 1.1e-11 45.1 0.2 1.8e-11 44.3 0.2 1.4 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.4 012776.1_45726001_3 - 0.0021 17.3 0.0 0.0034 16.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like ATG16 PF08614.9 012776.1_45726001_3 - 0.2 11.7 1.4 0.29 11.2 0.2 1.8 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Spectrin PF00435.19 004020.3_26229001_1 - 8.2e-68 225.4 106.8 1.4e-13 51.1 3.1 10.5 8 2 2 10 10 10 8 Spectrin repeat EF-hand_2 PF09068.9 004020.3_26229001_1 - 2.9e-40 137.1 1.3 2.9e-40 137.1 1.3 2.3 2 0 0 2 2 2 1 EF hand EF-hand_3 PF09069.9 004020.3_26229001_1 - 1.5e-39 134.2 0.1 7.6e-39 131.9 0.0 2.4 2 0 0 2 2 2 1 EF-hand ZZ PF00569.15 004020.3_26229001_1 - 3.7e-19 68.1 4.2 7.9e-19 67.1 4.2 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type WW PF00397.24 004020.3_26229001_1 - 3.7e-09 36.2 2.1 1e-08 34.8 2.1 1.9 1 0 0 1 1 1 1 WW domain RasGEF PF00617.17 004020.3_26229001_1 - 0.13 12.3 1.8 0.54 10.3 1.8 2.1 1 0 0 1 1 1 0 RasGEF domain IL4 PF00727.16 001354990.1_26222001_2 - 4.1e-29 100.9 0.4 4.1e-29 100.9 0.4 1.5 2 0 0 2 2 2 1 Interleukin 4 Mannosyl_trans3 PF11051.6 001354990.1_26222001_2 - 0.055 12.6 0.0 0.068 12.4 0.0 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative IL4 PF00727.16 001354990.1_26222001_3 - 2e-13 50.4 2.3 2.6e-13 50.0 2.3 1.3 1 1 0 1 1 1 1 Interleukin 4 Ion_trans_2 PF07885.14 008430.2_32925001_2 - 9.1e-31 105.5 22.2 1e-16 60.5 3.6 3.5 4 0 0 4 4 4 2 Ion channel DUF935 PF06074.10 008430.2_32925001_2 - 0.11 11.1 0.2 0.16 10.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF935) P53 PF00870.16 001114982.1_26226001_1 - 2.6e-110 366.4 0.5 4.7e-110 365.6 0.5 1.4 1 0 0 1 1 1 1 P53 DNA-binding domain P53_tetramer PF07710.9 001114982.1_26226001_1 - 1e-18 66.2 0.4 2.4e-18 65.0 0.2 1.7 2 0 0 2 2 2 1 P53 tetramerisation motif Forkhead_N PF08430.10 001114982.1_26226001_1 - 0.24 11.9 3.5 0.41 11.1 3.5 1.3 1 0 0 1 1 1 0 Forkhead N-terminal region 7tm_1 PF00001.19 030985.4_45725001_1 - 1.1e-50 172.3 22.5 1.6e-50 171.7 22.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 030985.4_45725001_1 - 1.1e-07 31.4 21.5 1.8e-07 30.7 21.5 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 030985.4_45725001_1 - 0.39 9.9 27.5 1.5 7.9 26.5 2.1 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF2870 PF11069.6 001350328.1_39724001_3 - 9.9e-45 150.7 1.3 2.2e-44 149.6 1.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2870) DUF2870 PF11069.6 001168779.1_40422001_1 - 1.9e-43 146.6 0.9 1.9e-43 146.6 0.9 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2870) BRX PF08381.9 001168779.1_40422001_1 - 0.063 12.5 1.7 12 5.3 0.9 2.7 2 0 0 2 2 2 0 Transcription factor regulating root and shoot growth via Pin3 TTC5_OB PF16669.3 001080949.2_32924001_3 - 1.3e-40 137.5 0.0 2.1e-40 136.9 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat protein 5 OB fold domain TPR_11 PF13414.4 001080949.2_32924001_3 - 1.4e-07 31.0 5.4 8.5e-05 22.0 0.0 4.3 4 1 1 5 5 5 1 TPR repeat TPR_2 PF07719.15 001080949.2_32924001_3 - 3.1e-07 29.9 9.9 0.0017 18.2 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.4 001080949.2_32924001_3 - 9.9e-07 29.2 4.9 0.062 13.9 0.0 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.26 001080949.2_32924001_3 - 4.9e-06 26.0 9.4 0.099 12.4 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.4 001080949.2_32924001_3 - 0.00019 21.5 0.4 0.083 13.2 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.4 001080949.2_32924001_3 - 0.0037 17.6 3.4 0.083 13.3 0.0 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.4 001080949.2_32924001_3 - 0.0065 16.5 9.0 0.045 13.8 0.0 4.8 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_14 PF13428.4 001080949.2_32924001_3 - 0.0095 16.6 0.2 0.64 10.9 0.0 3.5 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.4 001080949.2_32924001_3 - 0.057 13.6 3.9 0.45 10.7 0.0 3.3 3 2 0 3 3 3 0 Tetratricopeptide repeat Abi_C PF14355.4 001080949.2_32924001_3 - 0.12 12.3 0.0 20 5.3 0.0 2.9 2 0 0 2 2 2 0 Abortive infection C-terminus SNARE PF05739.17 153434.1_32927120_1 - 5.7e-17 61.3 3.4 1.3e-16 60.2 3.4 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.23 153434.1_32927120_3 - 1.4e-53 181.4 11.6 2.1e-53 180.9 11.6 1.2 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.17 153434.1_32927120_3 - 3e-11 43.0 0.1 3e-11 43.0 0.1 2.0 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.4 153434.1_32927120_3 - 7.1e-06 26.2 4.6 7.1e-06 26.2 4.6 1.7 2 0 0 2 2 2 1 Syntaxin-like protein Branch PF02485.19 153434.1_32927120_3 - 0.00094 18.6 0.7 0.0015 18.0 0.7 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme SIMPL PF04402.12 153434.1_32927120_3 - 0.0021 18.4 0.6 0.0033 17.8 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF541) DUF1495 PF07381.9 153434.1_32927120_3 - 0.12 12.1 0.1 0.46 10.2 0.1 1.9 2 0 0 2 2 2 0 Winged helix DNA-binding domain (DUF1495) COMPASS-Shg1 PF05205.10 073160.1_45723120_2 - 9.2e-17 61.5 0.1 1.2e-16 61.1 0.1 1.2 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 PRIMA1 PF16101.3 073160.1_45723120_2 - 7.2 6.5 7.5 4.5 7.2 5.5 1.7 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 COMPASS-Shg1 PF05205.10 073160.1_45723120_3 - 0.26 11.9 0.0 0.38 11.3 0.0 1.2 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 Tmemb_14 PF03647.11 104454.1_26222120_1 - 8.1e-06 26.4 0.3 1.1e-05 26.0 0.3 1.2 1 0 0 1 1 1 1 Transmembrane proteins 14C PDEase_I PF00233.17 152194.1_32929120_2 - 6.3e-78 261.6 7.2 1.1e-77 260.9 7.2 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.24 152194.1_32929120_2 - 1.3e-26 93.6 1.4 1.2e-15 58.0 0.0 3.5 3 0 0 3 3 3 3 GAF domain GAF_2 PF13185.4 152194.1_32929120_2 - 4.1e-22 78.8 0.2 5.9e-09 36.2 0.0 3.6 3 0 0 3 3 3 2 GAF domain GAF_3 PF13492.4 152194.1_32929120_2 - 1.4e-10 41.5 0.1 3.1e-06 27.4 0.0 3.1 3 0 0 3 3 3 2 GAF domain DUF3819 PF12842.5 152194.1_32929120_2 - 0.25 11.2 1.7 16 5.3 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3819) TANGO2 PF05742.10 104274.2_26227120_1 - 1e-30 107.5 0.0 1.4e-30 107.1 0.0 1.1 1 0 0 1 1 1 1 Transport and Golgi organisation 2 TANGO2 PF05742.10 104274.2_26227120_2 - 6.1e-07 29.6 0.0 9.1e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Transport and Golgi organisation 2 Sema PF01403.17 109782.1_32929120_2 - 1.3e-31 109.7 0.0 1.9e-31 109.2 0.0 1.1 1 0 0 1 1 1 1 Sema domain Pkinase_Tyr PF07714.15 109782.1_32929120_3 - 1.8e-88 296.0 0.0 2.6e-88 295.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 109782.1_32929120_3 - 2.2e-37 128.7 0.0 3.2e-37 128.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain TIG PF01833.22 109782.1_32929120_3 - 4.6e-26 90.6 4.3 3.5e-10 39.7 0.1 4.0 4 0 0 4 4 4 3 IPT/TIG domain Sema PF01403.17 109782.1_32929120_3 - 6e-07 28.4 0.0 9.5e-07 27.8 0.0 1.2 1 0 0 1 1 1 1 Sema domain Kinase-like PF14531.4 109782.1_32929120_3 - 0.0077 15.4 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like TSLP PF15216.4 045089.1_26228120_1 - 2e-58 196.0 5.2 3.3e-58 195.3 5.2 1.4 1 0 0 1 1 1 1 Thymic stromal lymphopoietin PDGF PF00341.15 105011.1_45727120_1 - 5.2e-26 90.6 6.7 8.4e-26 90.0 6.7 1.3 1 0 0 1 1 1 1 PDGF/VEGF domain VEGF_C PF14554.4 105011.1_45727120_3 - 6.3e-28 96.5 19.5 1.3e-27 95.5 19.5 1.5 1 0 0 1 1 1 1 VEGF heparin-binding domain PDZ PF00595.22 148035.1_26229120_2 - 1.3e-23 83.0 0.0 9.3e-17 61.0 0.1 2.3 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 148035.1_26229120_2 - 0.00061 19.9 0.0 0.089 13.0 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.22 148035.1_26229120_3 - 5e-22 77.9 0.5 2.7e-11 43.5 0.2 2.3 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 148035.1_26229120_3 - 1.7e-06 28.1 0.0 0.052 13.7 0.0 2.4 2 0 0 2 2 2 2 PDZ domain CPSase_L_D2 PF02786.15 153443.1_32926120_3 - 1.5e-84 282.6 0.0 2.4e-84 281.9 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.20 153443.1_32926120_3 - 7.8e-46 155.0 0.4 1.7e-45 154.0 0.2 1.7 2 0 0 2 2 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.17 153443.1_32926120_3 - 7.2e-36 122.4 0.0 1.5e-35 121.4 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.20 153443.1_32926120_3 - 4.4e-19 68.0 3.0 1e-18 66.8 3.0 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.4 153443.1_32926120_3 - 1.4e-09 37.0 0.1 5e-09 35.2 0.1 1.7 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.11 153443.1_32926120_3 - 2.4e-09 36.9 0.0 7.4e-09 35.3 0.0 1.7 1 1 1 2 2 2 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.4 153443.1_32926120_3 - 1.5e-07 31.0 0.1 0.0011 18.6 0.0 2.7 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp PF02222.20 153443.1_32926120_3 - 7.7e-07 28.7 0.0 1.4e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.9 153443.1_32926120_3 - 8.5e-05 22.1 0.0 0.00018 21.0 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain SLT_beta PF02258.14 153443.1_32926120_3 - 0.0019 18.1 0.3 0.0073 16.2 0.1 2.1 2 0 0 2 2 2 1 Shiga-like toxin beta subunit ATP-grasp_3 PF02655.12 153443.1_32926120_3 - 0.0026 17.7 0.0 0.0071 16.3 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain HlyD_3 PF13437.4 153443.1_32926120_3 - 0.02 15.5 0.2 0.14 12.7 0.1 2.5 2 1 1 3 3 3 0 HlyD family secretion protein ATP-grasp_5 PF13549.4 153443.1_32926120_3 - 0.023 14.0 0.0 0.089 12.1 0.0 1.8 2 0 0 2 2 2 0 ATP-grasp domain HlyD_D23 PF16576.3 153443.1_32926120_3 - 0.073 12.1 0.1 0.31 10.1 0.0 1.9 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATPgrasp_ST PF14397.4 153443.1_32926120_3 - 0.092 11.8 0.0 0.35 10.0 0.0 1.8 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp Ribosomal_S24e PF01282.17 001360586.1_32924001_3 - 8.2e-45 150.6 0.5 1.3e-44 149.9 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e RNase_T PF00929.22 001162939.2_32929001_3 - 8.2e-15 55.6 0.0 1.2e-14 55.1 0.0 1.2 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.18 001162939.2_32929001_3 - 0.0056 16.3 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease Pkinase PF00069.23 153660.1_32925120_1 - 1.5e-41 142.3 0.0 7.6e-38 130.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 153660.1_32925120_1 - 4.4e-17 62.1 0.0 6.7e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.22 153660.1_32925120_1 - 1e-09 38.8 1.9 1e-09 38.8 1.9 2.2 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.4 153660.1_32925120_1 - 0.013 14.7 0.0 0.023 13.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pkinase PF00069.23 153660.1_32925120_2 - 9.4e-13 48.0 0.1 1.2e-12 47.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 153660.1_32925120_2 - 0.00013 21.2 0.0 0.00017 20.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 153661.1_32925120_1 - 9.7e-13 47.9 0.1 1.2e-12 47.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 153661.1_32925120_1 - 0.00014 21.1 0.0 0.00018 20.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 153661.1_32925120_3 - 1.6e-41 142.3 0.0 7.9e-38 130.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 153661.1_32925120_3 - 4.6e-17 62.0 0.0 6.9e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.22 153661.1_32925120_3 - 1e-09 38.8 1.9 1e-09 38.8 1.9 2.1 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.4 153661.1_32925120_3 - 0.014 14.6 0.0 0.023 13.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Seadorna_VP6 PF07407.9 153799.1_32928120_1 - 0.31 9.8 1.0 0.63 8.8 1.0 1.5 1 0 0 1 1 1 0 Seadornavirus VP6 protein ATG16 PF08614.9 153799.1_32928120_1 - 1.8 8.5 66.9 0.41 10.7 7.6 4.3 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) CorA PF01544.16 153799.1_32928120_3 - 0.034 13.3 4.2 0.05 12.8 4.2 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein OmpH PF03938.12 153799.1_32928120_3 - 6.6 6.6 10.3 11 5.8 10.3 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) VWD PF00094.23 001246221.1_49829001_1 - 2.9e-127 420.7 17.8 1.1e-38 132.9 0.1 4.8 5 0 0 5 5 5 4 von Willebrand factor type D domain VWA PF00092.26 001246221.1_49829001_1 - 2.9e-81 271.8 0.0 2.2e-30 106.0 0.0 3.2 3 0 0 3 3 3 3 von Willebrand factor type A domain C8 PF08742.9 001246221.1_49829001_1 - 4.6e-55 183.8 59.4 1.8e-18 66.5 7.2 8.4 9 0 0 9 9 9 4 C8 domain VWA_N2 PF16164.3 001246221.1_49829001_1 - 1.6e-35 121.0 4.4 1.6e-35 121.0 4.4 8.8 9 0 0 9 9 9 1 VWA N-terminal TIL PF01826.15 001246221.1_49829001_1 - 2.8e-30 104.2 108.2 9.1e-13 48.1 13.2 19.3 17 3 4 21 21 21 5 Trypsin Inhibitor like cysteine rich domain VWC PF00093.16 001246221.1_49829001_1 - 5.4e-17 61.7 68.1 1.9e-08 34.3 12.2 21.2 15 4 4 19 19 19 6 von Willebrand factor type C domain VWA_3 PF13768.4 001246221.1_49829001_1 - 1.7e-06 27.9 0.0 0.38 10.5 0.0 3.3 3 0 0 3 3 3 2 von Willebrand factor type A domain Pacifastin_I PF05375.11 001246221.1_49829001_1 - 5.4e-05 22.7 7.1 5.4e-05 22.7 7.1 12.5 15 0 0 15 15 15 3 Pacifastin inhibitor (LCMII) PTPlike_phytase PF14566.4 013753.2_32929001_1 - 1.4e-61 207.1 0.0 1e-36 126.3 0.0 3.5 2 1 0 2 2 2 2 Inositol hexakisphosphate V-set PF07686.15 001291021.1_32927001_1 - 3e-16 59.4 0.0 5.2e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001291021.1_32927001_1 - 3.3e-07 30.7 0.0 6.7e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001291021.1_32927001_1 - 5.6e-06 26.3 0.0 1.2e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001291021.1_32927001_1 - 0.00013 21.8 0.0 0.00025 20.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 001291021.1_32927001_1 - 0.0035 17.5 0.0 0.0082 16.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain SIT PF15330.4 001291021.1_32927001_1 - 0.0042 17.4 0.1 0.02 15.2 0.1 2.0 1 1 1 2 2 2 1 SHP2-interacting transmembrane adaptor protein, SIT Rax2 PF12768.5 001291021.1_32927001_1 - 0.19 11.2 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Miga PF10265.7 001242407.1_32927001_1 - 4.8e-224 745.2 0.0 5.6e-224 745.0 0.0 1.0 1 0 0 1 1 1 1 Mitoguardin bZIP_1 PF00170.19 001205052.1_32924001_3 - 8.9e-10 38.4 20.2 2.2e-09 37.2 20.2 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001205052.1_32924001_3 - 1.2e-06 28.3 20.7 1.2e-06 28.3 20.7 1.9 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.15 001205052.1_32924001_3 - 8.2e-06 26.1 14.1 8.2e-06 26.1 14.1 1.7 2 0 0 2 2 2 1 bZIP Maf transcription factor Macoilin PF09726.7 001205052.1_32924001_3 - 0.56 8.6 9.6 0.77 8.1 9.6 1.1 1 0 0 1 1 1 0 Transmembrane protein HLH PF00010.24 001290405.1_26229001_2 - 3.1e-15 55.7 0.2 4.9e-15 55.1 0.2 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain COE1_HLH PF16423.3 001290405.1_26229001_2 - 0.11 12.1 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Transcription factor COE1 helix-loop-helix domain Complex1_49kDa PF00346.17 001279739.1_24223001_1 - 2.9e-129 429.8 0.0 3.9e-129 429.4 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.17 001279739.1_24223001_1 - 0.031 13.0 0.0 0.046 12.5 0.0 1.2 1 0 0 1 1 1 0 Nickel-dependent hydrogenase Claudin_2 PF13903.4 019255.1_45722001_2 - 3.6e-37 127.9 6.2 4.6e-37 127.5 6.2 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.18 019255.1_45722001_2 - 1.9e-11 44.0 13.3 1.3e-09 38.1 13.3 2.2 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family DUF981 PF06168.9 019255.1_45722001_2 - 0.073 12.8 2.6 0.22 11.3 2.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF981) DUF1049 PF06305.9 019255.1_45722001_2 - 0.12 12.0 2.6 3.1 7.5 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1049) Claudin_3 PF06653.9 019255.1_45722001_2 - 0.26 11.1 9.3 2.6 7.8 9.3 2.2 1 1 0 1 1 1 0 Tight junction protein, Claudin-like Acyl_transf_3 PF01757.20 019255.1_45722001_2 - 0.41 9.5 11.4 0.075 11.9 4.2 2.2 2 1 1 3 3 3 0 Acyltransferase family PDR_assoc PF08370.9 019255.1_45722001_2 - 0.42 10.2 4.0 3.1 7.4 0.4 2.4 2 0 0 2 2 2 0 Plant PDR ABC transporter associated DUF805 PF05656.12 019255.1_45722001_2 - 0.51 10.6 3.4 0.42 10.9 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF805) fn3 PF00041.19 199121.2_26229001_3 - 7.5e-18 64.5 0.0 9.3e-10 38.6 0.0 2.5 2 0 0 2 2 2 2 Fibronectin type III domain NDK PF00334.17 001044610.2_49822001_1 - 9.4e-55 184.2 0.0 2.2e-54 183.0 0.0 1.5 2 0 0 2 2 2 1 Nucleoside diphosphate kinase Casein PF00363.16 001082759.2_37923001_1 - 6.2e-21 74.7 16.1 6.2e-21 74.7 16.1 2.5 2 1 0 2 2 2 1 Casein zf-C3HC4_2 PF13923.4 001082759.2_37923001_3 - 0.09 12.5 2.5 0.23 11.2 2.5 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pkinase_Tyr PF07714.15 009595.3_32929001_2 - 7.2e-97 323.6 0.0 1e-96 323.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 009595.3_32929001_2 - 1.5e-45 155.5 0.0 2.3e-45 154.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain F_actin_bind PF08919.8 009595.3_32929001_2 - 1.1e-26 92.9 0.0 2.1e-26 92.1 0.0 1.4 1 0 0 1 1 1 1 F-actin binding SH2 PF00017.22 009595.3_32929001_2 - 2.3e-23 81.9 0.2 4.7e-23 80.9 0.2 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 009595.3_32929001_2 - 1.2e-11 43.9 0.0 2.2e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 009595.3_32929001_2 - 1.1e-06 28.2 0.1 3.2e-06 26.8 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.15 009595.3_32929001_2 - 1.5e-06 27.6 0.0 3.1e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 009595.3_32929001_2 - 0.00013 22.0 0.7 0.00028 21.0 0.7 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain Serpin PF00079.18 213812.1_49824001_3 - 1.9e-102 343.2 0.0 2.2e-102 343.0 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) TFIIF_beta PF02270.13 031042.3_45723001_2 - 1e-58 199.6 0.8 3.8e-41 142.0 2.8 2.1 1 1 1 2 2 2 2 Transcription initiation factor IIF, beta subunit Neil1-DNA_bind PF09292.8 001256552.1_26224001_2 - 4.9e-24 83.8 0.5 9.6e-24 82.9 0.5 1.5 1 0 0 1 1 1 1 Endonuclease VIII-like 1, DNA bind Fapy_DNA_glyco PF01149.22 001256552.1_26224001_2 - 3.8e-17 62.9 0.0 9.7e-17 61.5 0.0 1.7 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.12 001256552.1_26224001_2 - 7e-09 35.4 0.0 1.2e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain RRM_1 PF00076.20 057119.1_45724001_1 - 2.8e-21 75.0 0.0 4.3e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 057119.1_45724001_1 - 0.085 12.8 0.0 0.21 11.5 0.0 1.6 2 0 0 2 2 2 0 RNA binding motif RRM_occluded PF16842.3 057119.1_45724001_1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif Apt1 PF10351.7 057119.1_45724001_1 - 0.16 10.6 14.6 0.22 10.2 14.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain MIP-T3 PF10243.7 057119.1_45724001_1 - 2.9 6.4 14.0 3.8 6.0 14.0 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Cyclin_N PF00134.21 001031781.2_49825001_2 - 1.1e-18 67.1 0.1 1.7e-18 66.5 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain UPAR_LY6 PF00021.19 214170.1_49822001_3 - 0.94 10.1 17.2 0.11 13.0 11.1 2.5 2 1 0 2 2 2 0 u-PAR/Ly-6 domain PRY PF13765.4 001011665.2_45727001_1 - 1.1e-12 47.3 0.0 4e-12 45.4 0.0 2.1 2 0 0 2 2 1 1 SPRY-associated domain SPRY PF00622.26 001011665.2_45727001_1 - 2.7e-12 46.7 0.0 8.5e-12 45.1 0.0 1.8 1 1 1 2 2 2 1 SPRY domain zf-C3HC4_4 PF15227.4 001011665.2_45727001_1 - 1.1e-10 41.3 7.8 1.1e-10 41.3 7.8 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 001011665.2_45727001_1 - 1.2e-09 37.7 5.8 1.2e-09 37.7 5.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001011665.2_45727001_1 - 3e-09 36.5 5.6 8e-09 35.1 5.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001011665.2_45727001_1 - 7.1e-09 35.6 4.0 7.1e-09 35.6 4.0 3.1 3 0 0 3 3 3 1 B-box zinc finger zf-C3HC4_2 PF13923.4 001011665.2_45727001_1 - 1.5e-08 34.2 6.5 3.8e-08 32.9 6.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001011665.2_45727001_1 - 2e-08 34.0 6.6 2.5e-08 33.7 3.3 2.6 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.4 001011665.2_45727001_1 - 4.2e-07 30.0 7.5 4.2e-07 30.0 7.5 2.0 2 0 0 2 2 1 1 Ring finger domain zf-RING_6 PF14835.4 001011665.2_45727001_1 - 1.4e-06 28.0 3.4 2.6e-06 27.1 3.4 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.4 001011665.2_45727001_1 - 1.8e-05 24.5 5.5 1.8e-05 24.5 5.5 2.2 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.4 001011665.2_45727001_1 - 9.7e-05 22.0 7.3 9.7e-05 22.0 7.3 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 Baculo_IE-1 PF05290.9 001011665.2_45727001_1 - 0.0024 17.7 1.8 0.0046 16.8 1.8 1.4 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) Nop14 PF04147.10 001011665.2_45727001_1 - 0.0034 15.6 6.7 0.0048 15.1 6.7 1.1 1 0 0 1 1 1 1 Nop14-like family zf-RING_10 PF16685.3 001011665.2_45727001_1 - 0.0072 16.3 3.8 0.0072 16.3 3.8 2.2 2 0 0 2 2 2 1 zinc RING finger of MSL2 CDC45 PF02724.12 001011665.2_45727001_1 - 0.024 12.9 1.9 0.035 12.3 1.9 1.1 1 0 0 1 1 1 0 CDC45-like protein zf-RING_4 PF14570.4 001011665.2_45727001_1 - 1.3 8.7 10.5 0.099 12.3 5.3 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Rtf2 PF04641.10 001011665.2_45727001_1 - 2.1 7.5 6.9 0.079 12.2 0.2 1.8 2 0 0 2 2 2 0 Rtf2 RING-finger Pkinase PF00069.23 020791.2_26229001_3 - 3.4e-64 216.6 0.0 6.5e-64 215.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 020791.2_26229001_3 - 3.2e-43 147.8 0.0 6.7e-43 146.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 020791.2_26229001_3 - 0.0073 16.1 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF2870 PF11069.6 001171500.1_37922001_1 - 4.3e-45 151.9 0.8 4.3e-45 151.9 0.8 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2870) BRX PF08381.9 001171500.1_37922001_1 - 0.076 12.3 2.3 12 5.2 0.9 2.9 3 0 0 3 3 3 0 Transcription factor regulating root and shoot growth via Pin3 Ssl1 PF04056.12 153794.1_32924120_3 - 1.7e-95 318.2 0.1 2.3e-95 317.8 0.1 1.2 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.4 153794.1_32924120_3 - 2.1e-12 47.5 0.0 5.5e-12 46.2 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain C1_4 PF07975.10 153794.1_32924120_3 - 3.7e-11 43.0 28.1 4.8e-10 39.4 21.4 3.0 2 1 0 2 2 2 2 TFIIH C1-like domain VWA PF00092.26 153794.1_32924120_3 - 2e-06 28.1 0.0 2.8e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 153794.1_32924120_3 - 0.026 14.3 0.0 0.07 12.9 0.0 1.7 2 0 0 2 2 2 0 von Willebrand factor type A domain IBR PF01485.19 153794.1_32924120_3 - 0.07 13.2 14.6 0.11 12.6 8.8 2.8 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain DZR PF12773.5 153794.1_32924120_3 - 9.1 6.3 22.6 16 5.5 13.0 3.1 1 1 3 4 4 4 0 Double zinc ribbon AXH PF08517.10 012257.3_26226001_1 - 3.5e-33 114.4 0.0 6.2e-33 113.6 0.0 1.4 1 0 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) HMG_box PF00505.17 012257.3_26226001_1 - 1.3e-14 54.2 0.9 2.6e-14 53.3 0.9 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 012257.3_26226001_1 - 5.5e-09 36.4 1.6 1.1e-08 35.4 1.6 1.5 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.10 012257.3_26226001_1 - 0.0049 16.1 0.2 0.0092 15.2 0.2 1.3 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box Xlink PF00193.15 001001391.1_26229001_3 - 2.1e-18 66.3 0.0 4.8e-18 65.2 0.0 1.6 1 0 0 1 1 1 1 Extracellular link domain SNAP-25 PF00835.17 001322906.1_26225001_1 - 1.6e-20 73.0 0.2 3e-20 72.1 0.2 1.5 1 0 0 1 1 1 1 SNAP-25 family DUF5089 PF17002.3 001322906.1_26225001_1 - 1.4e-05 24.9 4.9 2e-05 24.4 4.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5089) V-SNARE_C PF12352.6 001322906.1_26225001_1 - 0.72 10.0 5.5 0.32 11.2 0.7 2.7 2 1 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Exonuc_VII_L PF02601.13 001322906.1_26225001_1 - 0.89 8.9 6.0 3.1 7.1 6.0 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit IncA PF04156.12 001322906.1_26225001_1 - 1.2 8.7 4.1 0.51 10.0 0.5 1.9 2 0 0 2 2 2 0 IncA protein Spc7 PF08317.9 001322906.1_26225001_1 - 2.8 6.6 9.1 0.33 9.7 2.4 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Snapin_Pallidin PF14712.4 001322906.1_26225001_1 - 3.4 8.1 9.7 4.9 7.5 4.2 2.4 2 0 0 2 2 2 0 Snapin/Pallidin Alanine_zipper PF11839.6 001322906.1_26225001_1 - 5.7 7.1 7.7 7.5 6.8 0.1 3.2 2 1 1 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein Hist_deacetyl PF00850.17 010413.3_32929001_1 - 1.8e-172 572.7 0.0 1.2e-86 290.9 0.0 2.3 2 0 0 2 2 2 2 Histone deacetylase domain zf-UBP PF02148.17 010413.3_32929001_1 - 1.3e-13 51.0 19.7 1.3e-13 51.0 19.7 1.9 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein zf-HIT PF04438.14 010413.3_32929001_1 - 1.4 8.8 7.4 4 7.3 6.2 2.5 2 0 0 2 2 2 0 HIT zinc finger V-set PF07686.15 001103199.1_32928001_1 - 3.1e-13 49.7 0.0 8.8e-13 48.2 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001103199.1_32928001_1 - 8.8e-10 38.9 0.7 1.1e-05 25.8 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 001103199.1_32928001_1 - 9.6e-05 22.2 0.0 0.033 14.1 0.0 3.4 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.23 001103199.1_32928001_1 - 0.00015 21.7 0.0 0.0038 17.2 0.0 2.8 2 1 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 001103199.1_32928001_1 - 0.013 15.4 0.0 0.051 13.5 0.0 2.0 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain DUF1539 PF07560.9 001103199.1_32928001_1 - 0.21 11.6 71.4 1.4 8.9 3.8 10.1 3 2 4 8 8 8 0 Domain of Unknown Function (DUF1539) P53_C PF11619.6 001103199.1_32928001_1 - 3.5 7.6 41.7 35 4.4 0.0 14.7 8 4 9 19 19 19 0 Transcription factor P53 - C terminal domain DUF1979 PF09322.8 001103199.1_32928001_3 - 0.032 14.0 0.5 1.4e+02 2.3 0.0 5.6 7 0 0 7 7 7 0 Domain of unknown function (DUF1979) SLBP_RNA_bind PF15247.4 001103199.1_32928001_3 - 1.7 8.7 14.2 24 5.0 0.0 6.9 8 1 1 9 9 9 0 Histone RNA hairpin-binding protein RNA-binding domain Sushi PF00084.18 008358.2_32924001_2 - 0.00028 21.3 0.4 0.00073 20.0 0.4 1.8 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) DUF3180 PF11377.6 008358.2_32924001_2 - 0.026 14.5 0.2 0.054 13.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3180) Kelch_1 PF01344.23 016679.4_32929001_1 - 8e-85 278.1 15.9 6.1e-17 60.8 0.1 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 016679.4_32929001_1 - 2.3e-48 160.9 6.9 1.3e-10 41.0 0.1 6.5 2 2 4 6 6 6 6 Kelch motif BACK PF07707.13 016679.4_32929001_1 - 2.2e-33 114.3 0.2 4.4e-33 113.3 0.2 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.4 016679.4_32929001_1 - 1.3e-31 108.1 14.4 6.4e-07 29.4 0.2 7.1 6 0 0 6 6 6 6 Galactose oxidase, central domain BTB PF00651.29 016679.4_32929001_1 - 1.9e-29 102.0 0.2 2.9e-29 101.4 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_2 PF07646.13 016679.4_32929001_1 - 9e-26 88.7 4.5 7.2e-07 28.8 0.0 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.4 016679.4_32929001_1 - 1.3e-19 69.8 5.7 0.0017 18.1 0.1 6.2 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.4 016679.4_32929001_1 - 0.0006 19.6 12.6 1.6 8.7 0.1 6.0 6 0 0 6 6 6 2 Kelch motif PPARgamma_N PF12577.6 015869.4_26224001_2 - 2e-32 111.6 0.9 6.9e-32 109.8 1.3 1.8 2 0 0 2 2 2 1 PPAR gamma N-terminal region zf-C4 PF00105.16 015869.4_26224001_2 - 2e-27 95.3 15.0 3.7e-27 94.5 15.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 015869.4_26224001_2 - 1.9e-16 60.2 0.1 4.6e-16 58.9 0.1 1.7 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Tmemb_55A PF09788.7 015869.4_26224001_2 - 0.026 13.5 3.1 0.042 12.8 3.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 55A LRR_8 PF13855.4 001130425.1_29625001_1 - 4.7e-34 115.8 47.7 2.1e-13 49.7 7.0 8.0 5 2 2 7 7 7 7 Leucine rich repeat TIR PF01582.18 001130425.1_29625001_1 - 1.6e-21 76.8 1.7 1.8e-21 76.6 0.6 1.7 2 0 0 2 2 2 1 TIR domain LRR_4 PF12799.5 001130425.1_29625001_1 - 1.6e-18 66.3 49.7 0.0005 20.2 5.1 9.6 7 1 4 11 11 11 8 Leucine Rich repeats (2 copies) TIR_2 PF13676.4 001130425.1_29625001_1 - 4.7e-10 39.6 0.1 1.7e-09 37.8 0.0 1.9 2 0 0 2 2 2 1 TIR domain LRR_9 PF14580.4 001130425.1_29625001_1 - 1.2e-09 37.8 17.7 0.00012 21.5 0.3 5.0 2 2 2 4 4 4 2 Leucine-rich repeat LRR_5 PF13306.4 001130425.1_29625001_1 - 6.4e-05 22.8 0.4 6.4e-05 22.8 0.4 4.2 3 1 1 4 4 4 2 Leucine rich repeats (6 copies) LRRCT PF01463.22 001130425.1_29625001_1 - 0.00013 22.1 0.2 0.00051 20.2 0.2 2.2 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain LRR_1 PF00560.31 001130425.1_29625001_1 - 0.053 13.9 43.7 0.1 13.0 0.5 11.4 11 3 0 11 11 11 0 Leucine Rich Repeat DUF1863 PF08937.9 001130425.1_29625001_1 - 0.17 12.1 0.4 0.72 10.0 0.4 2.0 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) 7tm_1 PF00001.19 001355655.1_32929001_3 - 9.3e-45 152.8 18.0 1.3e-44 152.3 18.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001355655.1_32929001_3 - 2.1e-05 23.9 18.3 3.3e-05 23.3 18.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Spectrin PF00435.19 001276764.1_32929001_3 - 3.7e-203 660.4 465.7 4e-17 62.5 4.4 43.2 41 3 3 44 44 44 31 Spectrin repeat CH PF00307.29 001276764.1_32929001_3 - 4.5e-43 145.8 8.2 6.6e-22 77.6 0.3 6.0 6 0 0 6 6 6 2 Calponin homology (CH) domain Plectin PF00681.18 001276764.1_32929001_3 - 3.8e-41 138.5 10.7 7.3e-11 41.6 0.1 9.7 7 1 2 9 9 9 7 Plectin repeat GAS2 PF02187.15 001276764.1_32929001_3 - 3e-30 104.0 0.4 1e-29 102.3 0.4 2.0 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain EF-hand_1 PF00036.30 001276764.1_32929001_3 - 4.4e-12 44.5 1.3 0.00014 21.0 0.8 3.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 001276764.1_32929001_3 - 2.7e-10 39.2 3.7 0.00062 19.4 0.4 4.0 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.4 001276764.1_32929001_3 - 2.3e-09 37.5 0.9 2.3e-09 37.5 0.9 5.1 5 0 0 5 5 5 1 EF-hand domain pair EF-hand_8 PF13833.4 001276764.1_32929001_3 - 7e-08 32.0 0.4 3.6e-06 26.5 0.1 3.6 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.4 001276764.1_32929001_3 - 1.3e-07 30.7 4.1 4.2e-05 22.7 1.4 3.1 2 0 0 2 2 2 2 EF hand CAMSAP_CH PF11971.6 001276764.1_32929001_3 - 5e-06 26.1 0.1 0.0043 16.7 0.0 3.1 2 0 0 2 2 2 2 CAMSAP CH domain Laminin_II PF06009.10 001276764.1_32929001_3 - 0.0003 20.7 1.1 0.0003 20.7 1.1 26.3 26 5 6 32 32 32 1 Laminin Domain II EF-hand_6 PF13405.4 001352671.1_26224001_3 - 2.4e-05 23.8 0.2 0.00011 21.7 0.2 2.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.30 001352671.1_26224001_3 - 0.00041 19.6 0.3 0.0017 17.7 0.3 2.1 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.4 001352671.1_26224001_3 - 0.015 14.7 0.9 0.059 12.8 0.3 2.4 2 0 0 2 2 2 0 EF hand Put_DNA-bind_N PF06971.11 001352671.1_26224001_3 - 0.96 9.4 2.7 0.97 9.4 0.0 2.4 3 0 0 3 3 3 0 Putative DNA-binding protein N-terminus EF-hand_7 PF13499.4 001352671.1_26224001_3 - 1 9.7 17.0 0.041 14.2 8.3 3.2 2 2 0 2 2 2 0 EF-hand domain pair Macoilin PF09726.7 001352671.1_26224001_3 - 1.3 7.3 19.5 2.2 6.6 19.5 1.3 1 0 0 1 1 1 0 Transmembrane protein Vma12 PF11712.6 001352671.1_26224001_3 - 6.2 6.7 12.0 7.6 6.4 2.7 2.5 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Histone_HNS PF00816.19 001352671.1_26224001_3 - 7.5 7.3 11.6 0.21 12.3 1.5 2.9 3 0 0 3 3 3 0 H-NS histone family 7tm_1 PF00001.19 032075.3_45723001_1 - 3.6e-49 167.3 12.4 4.7e-49 166.9 12.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 032075.3_45723001_1 - 2e-09 37.1 9.0 4.8e-09 35.8 9.0 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.7 032075.3_45723001_1 - 7.8e-07 28.6 6.0 1.3e-06 27.8 6.0 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 032075.3_45723001_1 - 4.1e-06 26.2 12.8 5.9e-06 25.7 12.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 032075.3_45723001_1 - 0.0001 22.0 9.2 0.00077 19.1 3.2 2.3 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 032075.3_45723001_1 - 0.00066 19.0 5.8 0.00066 19.0 5.8 2.1 3 0 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx adh_short PF00106.23 001194401.1_29624001_1 - 3e-34 118.1 0.2 1.1e-33 116.2 0.2 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001194401.1_29624001_1 - 3e-21 75.9 0.1 6.6e-21 74.8 0.1 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001194401.1_29624001_1 - 9.9e-09 35.2 0.1 1.5e-08 34.6 0.1 1.2 1 0 0 1 1 1 1 KR domain AdoHcyase_NAD PF00670.19 001194401.1_29624001_1 - 0.013 15.5 0.1 0.022 14.7 0.1 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Epimerase PF01370.19 001194401.1_29624001_1 - 0.069 12.5 0.1 0.1 11.9 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family LBP_BPI_CETP_C PF02886.15 001306124.1_39524001_3 - 1.4e-87 293.0 0.1 2.4e-87 292.2 0.1 1.4 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.23 001306124.1_39524001_3 - 1.5e-49 167.6 0.0 2.5e-49 166.9 0.0 1.4 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain adh_short PF00106.23 001243402.1_49825001_1 - 4.5e-35 120.7 0.1 1.7e-34 118.8 0.1 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001243402.1_49825001_1 - 9.2e-23 80.9 0.0 1.6e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001243402.1_49825001_1 - 2.9e-08 33.7 0.5 8.8e-08 32.1 0.4 1.7 1 1 1 2 2 2 1 KR domain Epimerase PF01370.19 001243402.1_49825001_1 - 0.03 13.6 0.2 0.05 12.9 0.2 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family AdoHcyase_NAD PF00670.19 001243402.1_49825001_1 - 0.042 13.8 0.1 0.071 13.1 0.1 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Pyr_redox_3 PF13738.4 001243402.1_49825001_1 - 0.22 10.6 0.0 0.33 10.0 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase LBP_BPI_CETP_C PF02886.15 001314172.1_09023001_1 - 3.6e-88 294.9 0.2 6.6e-88 294.0 0.2 1.4 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.23 001314172.1_09023001_1 - 5.9e-50 169.0 0.0 1.1e-49 168.1 0.0 1.4 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.15 001159307.1_49824001_3 - 1.5e-80 269.9 1.0 1.9e-80 269.6 0.3 1.5 2 0 0 2 2 2 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.23 001159307.1_49824001_3 - 6.2e-48 162.4 0.0 1.5e-47 161.1 0.0 1.7 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain Rhabdo_ncap PF00945.16 001159307.1_49824001_3 - 0.051 12.3 0.0 0.074 11.8 0.0 1.1 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein GRASP55_65 PF04495.12 103866.1_26227120_1 - 0.00092 19.4 0.1 0.0015 18.7 0.1 1.3 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain GRASP55_65 PF04495.12 103866.1_26227120_3 - 3.8e-56 189.1 0.0 9e-37 126.3 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.4 103866.1_26227120_3 - 4.9e-08 33.0 0.0 2.3e-05 24.5 0.0 2.2 2 0 0 2 2 2 2 PDZ domain Band_7 PF01145.23 073077.1_45726120_1 - 2.6e-14 53.5 0.0 2.6e-14 53.5 0.0 2.5 2 1 0 2 2 2 1 SPFH domain / Band 7 family Flot PF15975.3 073077.1_45726120_1 - 1.6e-08 34.6 10.3 1.6e-08 34.6 10.3 3.4 2 1 2 4 4 4 2 Flotillin YjbH PF06082.9 073077.1_45726120_1 - 6.2 5.4 7.0 8.5 4.9 7.0 1.1 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH Band_7 PF01145.23 073076.1_45726120_1 - 6.1e-17 62.1 0.1 6.1e-17 62.1 0.1 2.5 2 1 0 2 2 2 1 SPFH domain / Band 7 family Flot PF15975.3 073076.1_45726120_1 - 1.8e-08 34.5 10.4 1.8e-08 34.5 10.4 3.4 2 1 2 4 4 4 2 Flotillin YjbH PF06082.9 073076.1_45726120_1 - 6.2 5.4 7.0 8.5 4.9 7.0 1.1 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH HlyIII PF03006.18 146462.1_26229120_1 - 3e-41 141.4 14.0 6e-41 140.5 14.0 1.4 1 0 0 1 1 1 1 Haemolysin-III related EF-hand_7 PF13499.4 046478.1_26229120_2 - 1.6e-07 31.5 3.1 2.9e-07 30.7 3.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 046478.1_26229120_2 - 7.8e-05 22.2 4.2 0.12 12.3 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.30 046478.1_26229120_2 - 0.0013 18.0 6.3 0.04 13.3 1.8 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.4 046478.1_26229120_2 - 0.0048 16.2 4.5 0.16 11.4 1.2 2.4 2 0 0 2 2 2 2 EF hand FKBP_C PF00254.26 046478.1_26229120_3 - 2.5e-20 72.5 0.0 3.8e-20 71.9 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase V-set PF07686.15 001360767.1_32922001_1 - 4.1e-09 36.4 0.0 6.4e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001360767.1_32922001_1 - 2.1e-05 24.9 0.0 4.2e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001360767.1_32922001_1 - 4e-05 23.5 0.0 6.7e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Adeno_E3_CR1 PF02440.13 001360767.1_32922001_1 - 0.025 14.2 0.2 0.045 13.4 0.2 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR1 ig PF00047.23 001360767.1_32922001_1 - 0.032 14.3 0.1 0.063 13.3 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Pkinase PF00069.23 001360809.1_32929001_3 - 4.7e-30 104.7 0.0 6.5e-30 104.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001360809.1_32929001_3 - 1.4e-13 50.6 0.0 2.3e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RRM_1 PF00076.20 001360809.1_32929001_3 - 5.7e-06 25.9 0.0 9.6e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kinase-like PF14531.4 001360809.1_32929001_3 - 2.2e-05 23.8 0.0 3.5e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001360809.1_32929001_3 - 0.0047 16.2 0.1 0.008 15.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001360809.1_32929001_3 - 0.0066 16.3 0.1 0.01 15.7 0.1 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.20 001360809.1_32929001_3 - 0.036 13.5 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Myosin_head PF00063.19 001360885.1_39729001_2 - 1e-285 949.2 6.7 1e-285 949.2 6.7 3.2 4 1 0 4 4 4 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 001360885.1_39729001_2 - 2.9e-159 531.9 274.7 3.6e-159 531.6 274.7 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 001360885.1_39729001_2 - 1.9e-11 43.5 1.1 5.4e-11 42.0 1.1 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 001360885.1_39729001_2 - 3.5e-05 23.2 78.1 0.014 14.7 3.5 9.2 2 2 9 11 11 11 10 Reovirus sigma C capsid protein TSNAXIP1_N PF15739.3 001360885.1_39729001_2 - 0.0063 16.8 7.7 0.0063 16.8 7.7 15.3 4 4 13 19 19 19 2 Translin-associated factor X-interacting N-terminus IQ PF00612.25 001360885.1_39729001_2 - 0.016 14.8 1.0 0.05 13.3 0.4 2.3 2 0 0 2 2 2 0 IQ calmodulin-binding motif AAA_22 PF13401.4 001360885.1_39729001_2 - 0.1 12.7 0.0 0.1 12.7 0.0 6.0 4 2 2 6 6 6 0 AAA domain AAA_16 PF13191.4 001360885.1_39729001_2 - 0.33 11.2 0.0 0.33 11.2 0.0 6.3 2 1 2 6 6 6 0 AAA ATPase domain PRK PF00485.16 001360885.1_39729001_2 - 4.7 6.8 8.2 2.4 7.7 0.2 3.8 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family LIM PF00412.20 153810.1_32924120_2 - 0.0012 18.9 4.4 0.0019 18.2 4.4 1.3 1 0 0 1 1 1 1 LIM domain zf-RING_2 PF13639.4 153810.1_32924120_2 - 0.44 10.7 4.6 0.48 10.6 3.3 1.8 2 0 0 2 2 2 0 Ring finger domain LIM PF00412.20 153810.1_32924120_3 - 1.4e-11 44.3 2.7 2.7e-11 43.4 2.7 1.4 1 0 0 1 1 1 1 LIM domain Zn-ribbon_8 PF09723.8 153810.1_32924120_3 - 0.48 10.4 3.1 1.2 9.2 3.1 1.7 1 0 0 1 1 1 0 Zinc ribbon domain TNFR_c6 PF00020.16 153810.1_32924120_3 - 3.7 7.9 8.7 0.92 9.8 1.9 2.4 2 0 0 2 2 2 0 TNFR/NGFR cysteine-rich region FF PF01846.17 110344.1_32929120_2 - 4.4e-64 212.3 44.0 4.4e-15 55.5 1.8 6.7 6 0 0 6 6 6 6 FF domain WW PF00397.24 110344.1_32929120_2 - 6.1e-22 77.1 22.8 7e-08 32.2 5.0 3.8 3 0 0 3 3 3 3 WW domain FF PF01846.17 110344.1_32929120_3 - 5.2e-05 23.2 0.1 0.00011 22.2 0.1 1.5 1 0 0 1 1 1 1 FF domain DNA_pol_phi PF04931.11 016776.3_32929001_1 - 6.5e-191 636.2 17.4 6.5e-191 636.2 17.4 2.1 2 0 0 2 2 2 1 DNA polymerase phi 7tm_4 PF13853.4 010997.1_32922001_1 - 8.8e-57 192.8 22.1 1.1e-56 192.6 22.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 010997.1_32922001_1 - 2.4e-27 95.7 27.0 8.1e-27 94.0 27.0 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 010997.1_32922001_1 - 4.2e-05 22.9 20.6 7.8e-05 22.0 20.6 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 010997.1_32922001_1 - 0.0019 17.4 22.7 0.0049 16.1 22.7 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Myosin_head PF00063.19 001081759.1_21029001_1 - 5.2e-286 950.2 2.9 5.2e-286 950.2 2.9 3.2 4 1 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 001081759.1_21029001_1 - 1.8e-164 549.2 269.4 2.2e-164 548.9 269.4 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 001081759.1_21029001_1 - 1e-13 50.7 2.2 2.9e-13 49.3 2.2 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 001081759.1_21029001_1 - 1.3e-06 27.9 71.7 0.016 14.5 3.4 9.1 1 1 7 10 10 10 8 Reovirus sigma C capsid protein BBP1_C PF15272.4 001081759.1_21029001_1 - 0.0028 17.4 15.1 0.0028 17.4 15.1 9.9 1 1 7 9 9 4 1 Spindle pole body component BBP1, C-terminal ADIP PF11559.6 001081759.1_21029001_1 - 0.0045 17.0 20.9 0.0045 17.0 20.9 12.1 3 3 8 11 11 11 6 Afadin- and alpha -actinin-Binding IQ PF00612.25 001081759.1_21029001_1 - 0.0058 16.2 3.2 0.014 15.0 1.1 2.7 2 0 0 2 2 2 1 IQ calmodulin-binding motif BRE1 PF08647.9 001081759.1_21029001_1 - 0.007 16.3 11.0 0.007 16.3 11.0 14.6 5 4 9 15 15 15 3 BRE1 E3 ubiquitin ligase AAA_22 PF13401.4 001081759.1_21029001_1 - 0.1 12.8 0.0 0.1 12.8 0.0 5.6 3 2 1 4 4 3 0 AAA domain Filament PF00038.19 001081759.1_21029001_1 - 0.13 11.7 231.3 0.017 14.6 11.6 8.9 1 1 6 8 8 8 0 Intermediate filament protein DUF1482 PF07358.9 001081759.1_21029001_1 - 0.34 10.7 1.5 30 4.5 0.1 3.0 3 0 0 3 3 2 0 Protein of unknown function (DUF1482) AAA_16 PF13191.4 001081759.1_21029001_1 - 0.49 10.6 0.0 0.49 10.6 0.0 6.1 4 2 1 5 5 2 0 AAA ATPase domain DUF1664 PF07889.10 001081759.1_21029001_1 - 2 8.3 159.1 0.017 15.0 8.2 14.0 1 1 14 15 15 15 0 Protein of unknown function (DUF1664) AMP-binding PF00501.26 001289180.1_26226001_1 - 3.6e-60 203.6 0.0 4.7e-60 203.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Cas_Cas2CT1978 PF09707.8 001289180.1_26226001_1 - 0.0055 16.6 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Cas2CT1978) AMP-binding PF00501.26 001289180.1_26226001_2 - 5.9e-09 34.9 0.0 8.2e-09 34.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Meleagrin PF08189.9 001289180.1_26226001_3 - 0.037 13.6 0.7 0.12 11.9 0.7 1.8 1 0 0 1 1 1 0 Meleagrin/Cygnin family RRM_1 PF00076.20 024404.2_45724001_1 - 1.1e-35 121.1 0.3 5e-17 61.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 024404.2_45724001_1 - 8.4e-18 64.1 0.6 2.2e-08 34.0 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif CBFNT PF08143.9 024404.2_45724001_1 - 1.4e-13 51.9 27.0 1.4e-13 51.9 27.0 3.3 3 0 0 3 3 3 1 CBFNT (NUC161) domain RRM_3 PF08777.9 024404.2_45724001_1 - 4.6e-05 23.3 0.4 0.06 13.3 0.1 2.5 2 1 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.4 024404.2_45724001_1 - 0.0022 17.8 0.0 0.13 12.1 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif NID PF07292.11 024404.2_45724001_1 - 0.005 17.3 0.6 0.058 13.9 0.0 2.3 2 1 0 2 2 2 1 Nmi/IFP 35 domain (NID) 14-3-3 PF00244.18 001253807.1_32927001_2 - 1.1e-106 355.1 4.5 1.5e-106 354.8 4.5 1.1 1 0 0 1 1 1 1 14-3-3 protein 14-3-3 PF00244.18 001356569.1_32928001_3 - 1.2e-109 364.9 6.2 1.5e-109 364.5 6.2 1.1 1 0 0 1 1 1 1 14-3-3 protein wnt PF00110.17 009519.2_32926001_3 - 7.2e-105 350.7 14.9 9.2e-105 350.4 14.9 1.1 1 0 0 1 1 1 1 wnt family NPP PF08384.8 001278581.1_32923001_2 - 7.8e-23 80.1 1.5 1.5e-22 79.2 1.5 1.5 1 0 0 1 1 1 1 Pro-opiomelanocortin, N-terminal region ACTH_domain PF00976.16 001278581.1_32923001_2 - 1.2e-20 72.9 27.8 7.8e-08 31.9 5.8 3.5 3 0 0 3 3 3 3 Corticotropin ACTH domain Op_neuropeptide PF08035.9 001278581.1_32923001_2 - 1.2e-16 60.2 0.1 2.3e-16 59.2 0.1 1.5 1 0 0 1 1 1 1 Opioids neuropeptide Hormone_recep PF00104.28 001243511.2_26229001_3 - 6.8e-32 110.6 0.6 1.2e-31 109.8 0.6 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001243511.2_26229001_3 - 6.9e-30 103.2 12.3 6.9e-30 103.2 12.3 2.7 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) NUDIX_5 PF16705.3 033173.1_32929120_1 - 3.6e-84 280.8 0.0 4.9e-84 280.3 0.0 1.2 1 0 0 1 1 1 1 NUDIX, or N-terminal NPxY motif-rich, region of KRIT Ank_2 PF12796.5 033173.1_32929120_1 - 0.12 12.8 0.0 0.24 11.9 0.0 1.4 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) FERM_M PF00373.16 033173.1_32929120_2 - 3.3e-18 66.1 0.1 6.1e-18 65.2 0.1 1.5 1 0 0 1 1 1 1 FERM central domain Ank_5 PF13857.4 033173.1_32929120_2 - 7.1e-09 35.7 0.0 1.3e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.5 033173.1_32929120_2 - 4e-08 33.6 0.0 7.8e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 033173.1_32929120_2 - 3.3e-05 24.2 0.0 7.6e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.28 033173.1_32929120_2 - 0.0034 17.7 0.1 0.065 13.6 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.4 033173.1_32929120_2 - 0.018 15.4 0.1 0.2 12.2 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat ANF_receptor PF01094.26 104053.1_32929120_1 - 3.1e-59 200.7 0.8 4.3e-59 200.3 0.8 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 104053.1_32929120_1 - 1e-51 174.5 0.0 1.9e-51 173.7 0.0 1.5 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 104053.1_32929120_1 - 7.5e-45 151.7 0.0 1.3e-44 150.9 0.0 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 104053.1_32929120_1 - 1.1e-21 77.1 0.0 1.8e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan PF00060.24 104053.1_32929120_2 - 0.00089 19.0 0.0 0.002 17.8 0.0 1.7 1 0 0 1 1 1 1 Ligand-gated ion channel Sprouty PF05210.11 001305440.1_32925001_1 - 1.7e-30 105.5 33.8 1.7e-30 105.5 33.8 1.7 2 0 0 2 2 2 1 Sprouty protein (Spry) 7tm_1 PF00001.19 000685.4_26225001_2 - 2.3e-50 171.2 22.7 3.4e-50 170.6 22.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 000685.4_26225001_2 - 3.6e-07 29.7 22.4 5.9e-07 29.0 22.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx p450 PF00067.20 019184.2_45724001_3 - 5.6e-162 539.5 0.1 6.4e-162 539.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3973 PF13119.4 019184.2_45724001_3 - 3.9 7.6 7.0 1.5 9.0 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3973) Ribonuclease_3 PF00636.24 030621.4_26229001_2 - 3.3e-69 230.0 0.0 2e-43 147.1 0.0 3.1 2 1 0 2 2 2 2 Ribonuclease III domain PAZ PF02170.20 030621.4_26229001_2 - 6e-39 132.9 0.5 1.7e-38 131.4 0.2 2.0 2 0 0 2 2 2 1 PAZ domain Dicer_dimer PF03368.12 030621.4_26229001_2 - 1.3e-24 86.0 0.0 4.1e-24 84.4 0.0 1.9 1 0 0 1 1 1 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.4 030621.4_26229001_2 - 7.5e-24 84.2 0.0 2.9e-16 59.7 0.0 3.3 3 1 0 3 3 3 2 Ribonuclease-III-like Helicase_C PF00271.29 030621.4_26229001_2 - 1.6e-17 63.7 0.0 4.8e-17 62.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 030621.4_26229001_2 - 9e-12 45.0 0.0 1.8e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.13 030621.4_26229001_2 - 1.4e-11 44.5 0.0 3.2e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Kazal_2 PF07648.13 001301375.1_32926001_3 - 2.1e-34 117.3 31.0 7.3e-13 48.4 1.6 4.4 4 0 0 4 4 4 3 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 001301375.1_32926001_3 - 1.4e-18 66.5 34.0 1.5e-06 28.0 5.0 4.0 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain FOLN PF09289.8 001301375.1_32926001_3 - 1.5e-06 28.1 12.7 1.5e-06 28.1 12.7 4.1 3 0 0 3 3 3 2 Follistatin/Osteonectin-like EGF domain DAP10 PF07213.9 198125.2_26222001_1 - 0.0011 18.8 2.3 0.0018 18.1 2.3 1.3 1 0 0 1 1 1 1 DAP10 membrane protein IncA PF04156.12 198125.2_26222001_1 - 0.074 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 IncA protein Ribonucleas_3_3 PF14622.4 001100412.1_26229001_1 - 1.3e-43 148.1 0.5 2e-23 82.8 0.0 3.0 3 0 0 3 3 3 2 Ribonuclease-III-like Ribonuclease_3 PF00636.24 001100412.1_26229001_1 - 1.7e-42 144.2 0.4 1.1e-20 74.0 0.1 2.8 2 0 0 2 2 2 2 Ribonuclease III domain dsrm PF00035.24 001100412.1_26229001_1 - 9.5e-15 54.9 0.0 2.9e-14 53.4 0.0 1.9 1 0 0 1 1 1 1 Double-stranded RNA binding motif MIP-T3 PF10243.7 001100412.1_26229001_1 - 4.1 5.9 29.7 8.3 4.9 29.7 1.4 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CUB PF00431.18 018534.3_26229001_3 - 2.5e-57 191.8 0.0 1.6e-28 99.1 0.0 2.5 2 0 0 2 2 2 2 CUB domain F5_F8_type_C PF00754.23 018534.3_26229001_3 - 5.4e-57 191.3 0.7 5e-28 97.6 0.0 2.4 2 0 0 2 2 2 2 F5/8 type C domain MAM PF00629.21 018534.3_26229001_3 - 3.3e-31 108.2 0.0 6.6e-31 107.2 0.0 1.5 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu Tet_JBP PF12851.5 030625.2_26229001_2 - 6e-143 476.1 0.0 6e-143 476.1 0.0 2.1 3 0 0 3 3 3 1 Oxygenase domain of the 2OGFeDO superfamily zf-CXXC PF02008.18 030625.2_26229001_2 - 2.8e-08 33.5 24.2 7.8e-08 32.1 24.2 1.8 1 0 0 1 1 1 1 CXXC zinc finger domain Lipoxygenase PF00305.17 001082282.1_37928001_1 - 7.4e-57 193.1 0.0 1.7e-55 188.6 0.0 2.5 1 1 0 1 1 1 1 Lipoxygenase PLAT PF01477.21 001082282.1_37928001_1 - 1.7e-19 70.4 0.0 2.9e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 PLAT/LH2 domain TPR_12 PF13424.4 001081973.1_45724001_3 - 2.4e-68 226.3 23.3 1.2e-20 73.5 2.2 5.6 3 1 3 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.4 001081973.1_45724001_3 - 2.6e-63 208.2 16.8 8.9e-16 57.1 0.0 7.0 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.4 001081973.1_45724001_3 - 1.2e-32 109.3 16.0 5.1e-06 26.0 0.0 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.26 001081973.1_45724001_3 - 1.6e-28 97.2 31.2 1.5e-07 30.8 0.5 7.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.15 001081973.1_45724001_3 - 1.7e-20 71.2 27.7 0.00038 20.2 2.7 6.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.4 001081973.1_45724001_3 - 1.8e-13 49.4 27.6 0.0016 18.4 0.1 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.4 001081973.1_45724001_3 - 9e-13 48.4 8.8 3e-05 24.3 0.2 4.8 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.4 001081973.1_45724001_3 - 3.4e-11 43.5 21.1 0.0011 19.5 2.2 6.7 3 1 3 6 6 5 5 Tetratricopeptide repeat TPR_14 PF13428.4 001081973.1_45724001_3 - 1.2e-10 41.1 9.6 1.2 10.0 0.3 7.1 3 1 3 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.4 001081973.1_45724001_3 - 1.1e-09 37.8 10.2 0.028 14.7 0.2 6.7 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_4 PF07721.12 001081973.1_45724001_3 - 3.5e-07 30.1 0.0 11 6.9 0.1 7.0 8 0 0 8 8 7 0 Tetratricopeptide repeat ANAPC3 PF12895.5 001081973.1_45724001_3 - 7.1e-07 29.2 11.3 0.034 14.2 0.1 4.4 2 1 2 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.18 001081973.1_45724001_3 - 8.1e-05 22.5 0.5 0.14 12.3 0.0 4.4 5 0 0 5 5 3 1 PPR repeat JIP_LZII PF16471.3 001081973.1_45724001_3 - 0.0069 16.4 7.4 0.0069 16.4 7.4 2.7 1 1 0 2 2 2 1 JNK-interacting protein leucine zipper II PPR_2 PF13041.4 001081973.1_45724001_3 - 0.044 13.9 1.1 2.5 8.2 0.0 3.6 3 0 0 3 3 3 0 PPR repeat family Gly_radical PF01228.19 001081973.1_45724001_3 - 0.12 12.8 2.3 57 4.2 0.0 4.1 2 1 2 5 5 4 0 Glycine radical GHL5 PF14872.4 001081973.1_45724001_3 - 0.13 10.1 6.0 0.21 9.4 6.0 1.2 1 0 0 1 1 1 0 Hypothetical glycoside hydrolase 5 SHNi-TPR PF10516.7 001081973.1_45724001_3 - 0.19 11.1 4.6 9.7 5.6 0.1 4.5 5 0 0 5 5 5 0 SHNi-TPR WbqC PF08889.9 001081973.1_45724001_3 - 0.22 11.3 8.5 13 5.5 0.0 4.2 4 1 1 5 5 5 0 WbqC-like protein family DUF4919 PF16266.3 001081973.1_45724001_3 - 0.23 11.3 0.1 0.23 11.3 0.1 3.1 3 2 1 4 4 4 0 Domain of unknown function (DUF4919) DUF627 PF04781.10 001081973.1_45724001_3 - 0.24 11.3 5.2 2.9 7.8 0.0 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF627) COG2 PF06148.9 001081973.1_45724001_3 - 1.1 9.3 10.2 0.28 11.1 5.9 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 MIT PF04212.16 001081973.1_45724001_3 - 1.5 8.8 14.8 18 5.4 2.8 5.5 4 2 2 6 6 5 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.4 001081973.1_45724001_3 - 2.7 7.6 20.5 0.3 10.7 0.7 6.1 6 0 0 6 6 6 0 TPR repeat TPR_3 PF07720.10 001081973.1_45724001_3 - 6.5 6.7 14.5 4 7.4 1.3 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Urotensin_II PF02083.13 019160.2_45722001_1 - 5.6e-07 28.7 1.9 1.1e-06 27.8 1.9 1.5 1 0 0 1 1 1 1 Urotensin II WH1 PF00568.21 053310.1_45723001_3 - 1.1e-36 125.0 0.1 1.7e-36 124.4 0.1 1.3 1 0 0 1 1 1 1 WH1 domain AAA_13 PF13166.4 053310.1_45723001_3 - 0.0051 15.4 11.3 0.0098 14.5 11.3 1.4 1 0 0 1 1 1 1 AAA domain Caldesmon PF02029.13 053310.1_45723001_3 - 0.0098 14.6 21.2 0.013 14.2 21.2 1.1 1 0 0 1 1 1 1 Caldesmon DUF4407 PF14362.4 053310.1_45723001_3 - 0.075 12.2 22.0 0.14 11.3 22.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Leu_zip PF15294.4 053310.1_45723001_3 - 0.13 11.6 16.9 20 4.4 16.9 2.3 1 1 0 1 1 1 0 Leucine zipper DUF4763 PF15960.3 053310.1_45723001_3 - 0.17 11.0 20.2 0.74 8.9 11.1 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4763) FlaC_arch PF05377.9 053310.1_45723001_3 - 0.17 12.1 8.4 4 7.8 0.2 3.7 4 0 0 4 4 3 0 Flagella accessory protein C (FlaC) Phlebovirus_NSM PF07246.9 053310.1_45723001_3 - 0.19 10.9 10.0 0.4 9.9 10.0 1.5 1 1 0 1 1 1 0 Phlebovirus nonstructural protein NS-M ATG16 PF08614.9 053310.1_45723001_3 - 0.4 10.7 33.8 12 5.8 19.4 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF2730 PF10805.6 053310.1_45723001_3 - 0.49 10.4 9.4 1.9 8.5 2.6 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) DUF3287 PF11690.6 053310.1_45723001_3 - 0.82 9.3 5.7 0.21 11.2 1.1 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3287) CENP-F_leu_zip PF10473.7 053310.1_45723001_3 - 1.1 9.1 26.2 7.3 6.5 23.8 2.7 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Not3 PF04065.13 053310.1_45723001_3 - 1.2 8.4 11.0 3.2 7.0 11.0 1.8 1 1 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component RasGAP_C PF03836.13 053310.1_45723001_3 - 1.2 9.2 7.4 0.79 9.7 2.4 2.4 1 1 1 2 2 2 0 RasGAP C-terminus Lebercilin PF15619.4 053310.1_45723001_3 - 1.5 8.3 28.1 5.7 6.4 23.3 2.7 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF3584 PF12128.6 053310.1_45723001_3 - 1.7 5.9 26.1 2.6 5.3 26.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Cob_adeno_trans PF01923.16 053310.1_45723001_3 - 1.8 8.5 10.6 0.43 10.6 3.5 2.2 1 1 1 2 2 2 0 Cobalamin adenosyltransferase PKcGMP_CC PF16808.3 053310.1_45723001_3 - 2.2 8.1 11.2 0.18 11.6 0.6 3.4 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Sec66 PF09802.7 053310.1_45723001_3 - 2.4 7.6 10.8 0.058 12.9 3.4 2.0 2 0 0 2 2 2 0 Preprotein translocase subunit Sec66 TMPIT PF07851.11 053310.1_45723001_3 - 2.4 7.2 17.1 0.25 10.4 4.5 2.9 2 1 2 4 4 4 0 TMPIT-like protein Allexi_40kDa PF05549.9 053310.1_45723001_3 - 3 7.1 5.6 3 7.2 3.9 1.5 1 1 1 2 2 2 0 Allexivirus 40kDa protein DUF342 PF03961.11 053310.1_45723001_3 - 3.2 6.1 9.4 3.7 5.9 8.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF342) DUF4686 PF15742.3 053310.1_45723001_3 - 3.2 6.6 26.3 36 3.2 25.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4686) Ax_dynein_light PF10211.7 053310.1_45723001_3 - 3.8 7.3 23.5 2 8.2 7.9 2.6 1 1 1 2 2 2 0 Axonemal dynein light chain HemX PF04375.12 053310.1_45723001_3 - 3.9 6.5 29.7 0.66 9.1 11.6 2.5 2 1 1 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase Lectin_N PF03954.12 053310.1_45723001_3 - 4 7.1 9.6 2.2 7.9 0.7 2.6 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain Golgin_A5 PF09787.7 053310.1_45723001_3 - 4.3 6.6 27.2 22 4.3 8.5 2.4 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF2353 PF09789.7 053310.1_45723001_3 - 4.7 6.4 19.0 11 5.1 19.0 1.6 1 1 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) CENP-H PF05837.10 053310.1_45723001_3 - 4.7 7.5 23.4 1.3 9.3 8.2 3.1 3 0 0 3 3 3 0 Centromere protein H (CENP-H) Phage_GP20 PF06810.9 053310.1_45723001_3 - 6.8 6.3 16.4 17 5.0 10.8 2.9 1 1 2 3 3 3 0 Phage minor structural protein GP20 Atg14 PF10186.7 053310.1_45723001_3 - 7.1 5.5 21.9 48 2.7 19.2 2.3 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Herpes_UL6 PF01763.14 053310.1_45723001_3 - 7.9 4.7 10.4 0.29 9.5 2.9 1.9 1 1 1 2 2 2 0 Herpesvirus UL6 like RRM_1 PF00076.20 002137.3_26228001_1 - 4e-31 106.5 0.0 2.6e-14 52.7 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 002137.3_26228001_1 - 4.7e-08 32.9 0.0 0.0016 18.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif Caveolin PF01146.15 001009477.1_39522001_1 - 3.2e-60 201.8 1.6 4.3e-60 201.3 1.6 1.1 1 0 0 1 1 1 1 Caveolin MBD PF01429.17 004992.3_26229001_2 - 3e-16 58.8 0.0 1e-15 57.1 0.0 1.9 1 0 0 1 1 1 1 Methyl-CpG binding domain 7tm_1 PF00001.19 001001621.1_49826001_2 - 2.4e-50 171.1 20.6 5.1e-50 170.1 20.6 1.6 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001001621.1_49826001_2 - 3.6e-09 36.2 23.1 4.8e-09 35.8 23.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Ras PF00071.20 001135664.1_26227001_3 - 2.7e-27 95.2 0.0 4e-27 94.7 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001135664.1_26227001_3 - 2e-14 53.7 0.0 3.4e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001135664.1_26227001_3 - 6.8e-08 32.0 0.1 1e-07 31.4 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Ion_trans PF00520.29 053684.1_45726001_3 - 7.1e-22 77.7 17.1 1e-21 77.2 17.1 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_N PF08412.8 053684.1_45726001_3 - 2.5e-20 71.7 0.0 4.8e-20 70.8 0.0 1.5 1 0 0 1 1 1 1 Ion transport protein N-terminal cNMP_binding PF00027.27 053684.1_45726001_3 - 4e-18 65.1 0.0 7e-18 64.3 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.14 053684.1_45726001_3 - 0.0028 17.5 0.1 0.0097 15.7 0.1 1.9 1 0 0 1 1 1 1 Ion channel TGFb_propeptide PF00688.16 000660.6_26226001_3 - 3.2e-39 135.0 0.0 4.3e-39 134.6 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 000660.6_26226001_3 - 7.3e-22 78.1 1.6 1.2e-21 77.4 1.6 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain wnt PF00110.17 001108111.1_45725001_2 - 4.1e-112 374.5 8.4 4.9e-112 374.3 8.4 1.1 1 0 0 1 1 1 1 wnt family p450 PF00067.20 214433.1_49823001_1 - 2.8e-99 332.8 0.0 3.1e-99 332.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ras PF00071.20 009007.2_32925001_2 - 6.3e-54 181.8 0.0 8e-54 181.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 009007.2_32925001_2 - 7.7e-22 77.6 0.0 1.1e-21 77.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 009007.2_32925001_2 - 7.4e-07 28.6 0.0 1e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PAS_3 PF08447.10 001308254.1_45729001_2 - 8e-20 70.8 0.2 1.2e-13 51.0 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 001308254.1_45729001_2 - 1.1e-15 57.5 0.0 8e-13 48.2 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 001308254.1_45729001_2 - 1.4e-10 41.2 0.2 7.8e-08 32.3 0.0 2.5 2 0 0 2 2 2 2 PAS domain HLH PF00010.24 001308254.1_45729001_2 - 1.4e-05 24.8 0.1 3e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_4 PF08448.8 001308254.1_45729001_2 - 0.014 15.5 2.3 0.19 11.8 0.0 2.9 3 0 0 3 3 3 0 PAS fold PHD PF00628.27 182931.2_26229001_1 - 1.1e-09 37.9 12.5 3.4e-09 36.3 12.5 1.9 1 0 0 1 1 1 1 PHD-finger SET PF00856.26 182931.2_26229001_1 - 2.5e-08 34.3 0.1 2.5e-08 34.3 0.1 2.6 2 0 0 2 2 2 1 SET domain PHD_2 PF13831.4 182931.2_26229001_1 - 0.0011 18.3 8.1 0.0031 16.9 8.1 1.8 1 0 0 1 1 1 1 PHD-finger PHD_3 PF13922.4 182931.2_26229001_1 - 0.11 12.8 2.1 1.1 9.5 2.1 2.9 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx MIP PF00230.18 012825.4_45729001_1 - 9e-72 241.3 17.4 1.6e-71 240.5 17.4 1.3 1 0 0 1 1 1 1 Major intrinsic protein PDGF_N PF04692.11 008808.3_32923001_3 - 3.1e-29 101.5 4.9 3.1e-29 101.5 4.9 1.9 2 0 0 2 2 2 1 Platelet-derived growth factor, N terminal region PDGF PF00341.15 008808.3_32923001_3 - 1.9e-21 76.0 10.8 3.7e-21 75.1 10.8 1.5 1 0 0 1 1 1 1 PDGF/VEGF domain An_peroxidase PF03098.13 001206745.1_26226001_3 - 2.2e-152 508.2 0.0 9.6e-113 377.4 0.0 2.1 1 1 1 2 2 2 2 Animal haem peroxidase EGF_CA PF07645.13 001206745.1_26226001_3 - 7.8e-11 41.9 5.8 7.8e-11 41.9 5.8 3.4 4 0 0 4 4 4 1 Calcium-binding EGF domain Sushi PF00084.18 001206745.1_26226001_3 - 2.1e-06 28.1 2.6 2.1e-06 28.1 2.6 2.2 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) EGF_3 PF12947.5 001206745.1_26226001_3 - 0.00032 20.7 7.3 0.00032 20.7 7.3 2.5 2 0 0 2 2 2 1 EGF domain FXa_inhibition PF14670.4 001206745.1_26226001_3 - 0.001 19.1 8.1 0.001 19.1 8.1 3.3 3 0 0 3 3 3 1 Coagulation Factor Xa inhibitory site cEGF PF12662.5 001206745.1_26226001_3 - 0.015 15.1 13.8 0.17 11.7 2.2 3.1 3 0 0 3 3 3 0 Complement Clr-like EGF-like BNIP3 PF06553.10 053420.3_45724001_2 - 1.2e-79 266.5 1.7 1.6e-79 266.0 1.7 1.1 1 0 0 1 1 1 1 BNIP3 V-set PF07686.15 001106884.1_45723001_2 - 2.1e-08 34.1 0.0 3.7e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Pro_isomerase PF00160.19 172243.1_45723001_3 - 1.3e-47 161.9 0.1 1.7e-47 161.5 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PFK PF00365.18 001323073.1_26225001_2 - 1.9e-137 457.1 0.7 1.8e-92 309.6 0.3 2.2 2 0 0 2 2 2 2 Phosphofructokinase Hrs_helical PF12210.6 001323073.1_26225001_2 - 0.11 12.9 1.0 15 6.0 0.0 2.8 3 0 0 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Ras PF00071.20 171994.4_45722001_2 - 5e-53 178.9 0.0 6.1e-53 178.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 171994.4_45722001_2 - 2.4e-19 69.6 0.0 3.9e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 171994.4_45722001_2 - 6.9e-08 32.0 0.0 1.1e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family PET117 PF15786.3 171994.4_45722001_2 - 0.0012 18.9 0.0 0.0012 18.9 0.0 1.6 2 0 0 2 2 2 1 PET assembly of cytochrome c oxidase, mitochondrial GTP_EFTU PF00009.25 171994.4_45722001_2 - 0.027 13.9 0.0 0.093 12.1 0.0 1.9 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain DOT1 PF08123.11 032482.2_26229001_1 - 2e-82 275.6 0.0 3.1e-82 275.0 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 Leptin PF02024.13 008493.3_32927001_3 - 2.6e-66 221.8 2.6 3.5e-66 221.3 2.6 1.2 1 0 0 1 1 1 1 Leptin PAS_3 PF08447.10 001308255.1_45729001_2 - 7.7e-20 70.8 0.2 1.2e-13 51.0 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 001308255.1_45729001_2 - 1.1e-15 57.5 0.0 7.7e-13 48.3 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 001308255.1_45729001_2 - 1.3e-10 41.3 0.2 7.5e-08 32.4 0.0 2.5 2 0 0 2 2 2 2 PAS domain HLH PF00010.24 001308255.1_45729001_2 - 1.2e-05 25.1 0.1 2.9e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_4 PF08448.8 001308255.1_45729001_2 - 0.013 15.6 2.3 0.18 11.9 0.0 2.9 3 0 0 3 3 3 0 PAS fold SH3_1 PF00018.26 021069.4_26229001_1 - 5.3e-41 137.9 0.3 5.1e-14 51.5 0.0 3.4 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.4 021069.4_26229001_1 - 7.1e-38 128.1 1.0 9.6e-13 47.6 0.1 4.1 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.15 021069.4_26229001_1 - 2.2e-27 94.4 0.6 1.7e-13 49.9 0.0 3.6 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.14 021069.4_26229001_1 - 4.3e-27 93.4 4.0 5.2e-26 89.9 0.6 2.5 2 0 0 2 2 2 2 Sorbin homologous domain BAF250_C PF12031.6 006015.5_26229001_3 - 3.2e-114 380.4 0.1 4.9e-114 379.8 0.1 1.3 1 0 0 1 1 1 1 SWI/SNF-like complex subunit BAF250/Osa ARID PF01388.19 006015.5_26229001_3 - 2e-14 53.9 0.1 3.9e-14 52.9 0.1 1.5 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain NPP PF08384.8 139326.2_45722001_2 - 1.7e-23 82.3 1.4 2.8e-23 81.5 1.4 1.4 1 0 0 1 1 1 1 Pro-opiomelanocortin, N-terminal region ACTH_domain PF00976.16 139326.2_45722001_2 - 1.2e-21 76.0 28.2 5.9e-08 32.3 5.8 3.5 3 0 0 3 3 3 3 Corticotropin ACTH domain Op_neuropeptide PF08035.9 139326.2_45722001_2 - 1e-16 60.3 0.1 1.7e-16 59.6 0.1 1.4 1 0 0 1 1 1 1 Opioids neuropeptide Pkinase PF00069.23 032080.1_45724001_2 - 1.9e-68 230.6 0.0 2.4e-68 230.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 032080.1_45724001_2 - 5.7e-24 84.7 0.0 7.9e-24 84.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 032080.1_45724001_2 - 6.5e-05 22.2 0.0 0.00043 19.6 0.0 2.0 1 1 1 2 2 2 1 Kinase-like APH PF01636.21 032080.1_45724001_2 - 0.007 16.2 0.1 0.015 15.1 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.12 032080.1_45724001_2 - 0.022 14.0 0.0 0.033 13.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.14 032080.1_45724001_2 - 0.093 12.8 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 ABC1 family TYW3 PF02676.12 032080.1_45724001_3 - 0.042 13.0 0.0 0.064 12.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase TYW3 Ank_5 PF13857.4 001195132.1_26223001_1 - 2.7e-10 40.2 2.2 0.00083 19.5 0.5 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 001195132.1_26223001_1 - 2.3e-07 31.1 0.0 0.015 15.8 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 001195132.1_26223001_1 - 2.4e-06 27.9 0.0 0.012 16.0 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 001195132.1_26223001_1 - 0.003 17.8 0.1 0.37 11.2 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeat DAGK_cat PF00781.22 001039341.1_45727001_2 - 3.4e-22 78.2 0.0 5.1e-22 77.7 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DAGK_acc PF00609.17 001039341.1_45727001_2 - 4.4e-12 46.5 0.0 7.1e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain C1_1 PF00130.20 001039341.1_45727001_2 - 1.3e-09 37.6 42.0 2.7e-06 27.0 13.5 2.8 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) DAGK_acc PF00609.17 001039341.1_45727001_3 - 1.4e-30 106.6 0.0 2.2e-30 106.0 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain UPAR_LY6 PF00021.19 002659.3_26224001_2 - 8.2e-25 87.2 47.7 5.2e-12 46.2 6.7 3.6 3 0 0 3 3 3 3 u-PAR/Ly-6 domain HECT PF00632.23 001354538.1_26229001_1 - 2.1e-92 309.8 0.3 4.2e-92 308.8 0.3 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.3 001354538.1_26229001_1 - 9.9e-18 64.0 3.5 2.7e-17 62.6 3.5 1.8 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A PCM1_C PF15717.3 001354538.1_26229001_1 - 0.05 12.2 4.6 0.1 11.1 4.6 1.4 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus NO_synthase PF02898.13 001129901.1_39529001_2 - 1.4e-180 600.0 0.0 1.8e-180 599.6 0.0 1.1 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.18 001129901.1_39529001_2 - 6.1e-84 280.9 0.0 1.5e-83 279.6 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.23 001129901.1_39529001_2 - 3.7e-52 176.2 0.0 6.4e-52 175.4 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.19 001129901.1_39529001_2 - 1.5e-17 64.1 0.0 3.3e-17 62.9 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain HTH_15 PF12324.6 001129901.1_39529001_2 - 0.053 13.3 0.2 0.14 12.0 0.2 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase SK_channel PF03530.12 019314.2_45725001_1 - 1.1e-48 163.8 0.4 1.1e-48 163.8 0.4 2.9 3 0 0 3 3 3 1 Calcium-activated SK potassium channel CaMBD PF02888.14 019314.2_45725001_1 - 7.4e-39 131.7 10.6 1.8e-38 130.5 10.6 1.7 1 0 0 1 1 1 1 Calmodulin binding domain Ion_trans_2 PF07885.14 019314.2_45725001_1 - 6.2e-13 48.4 2.9 6.2e-13 48.4 2.9 2.3 2 0 0 2 2 2 1 Ion channel Med9 PF07544.11 019314.2_45725001_1 - 0.011 15.7 0.5 0.026 14.5 0.4 1.7 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 PMP1_2 PF08114.9 019314.2_45725001_1 - 3.7 7.2 6.1 12 5.6 0.3 2.8 2 0 0 2 2 2 0 ATPase proteolipid family Prefoldin_2 PF01920.18 019314.2_45725001_1 - 6.4 6.7 9.9 44 4.0 6.2 3.0 1 1 1 2 2 2 0 Prefoldin subunit IZUMO PF15005.4 019314.2_45725001_1 - 9.4 6.6 6.6 11 6.4 5.7 1.6 1 1 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated PAS_3 PF08447.10 131776.1_45729120_2 - 8.7e-20 70.7 0.2 1.3e-13 50.9 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 131776.1_45729120_2 - 1.2e-15 57.3 0.0 8.2e-13 48.2 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 131776.1_45729120_2 - 1.5e-10 41.1 0.2 8e-08 32.3 0.0 2.5 2 0 0 2 2 2 2 PAS domain HLH PF00010.24 131776.1_45729120_2 - 1.3e-05 25.0 0.1 3e-05 23.7 0.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_4 PF08448.8 131776.1_45729120_2 - 0.016 15.3 2.5 0.2 11.8 0.0 2.9 3 0 0 3 3 3 0 PAS fold PAS_3 PF08447.10 131775.1_45729120_2 - 8.4e-20 70.7 0.2 1.3e-13 50.9 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 131775.1_45729120_2 - 1.2e-15 57.4 0.0 8.2e-13 48.2 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 131775.1_45729120_2 - 1.4e-10 41.1 0.2 8e-08 32.3 0.0 2.5 2 0 0 2 2 2 2 PAS domain HLH PF00010.24 131775.1_45729120_2 - 1.4e-05 24.8 0.1 3e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_4 PF08448.8 131775.1_45729120_2 - 0.016 15.3 2.5 0.2 11.8 0.0 2.9 3 0 0 3 3 3 0 PAS fold TNFR_c6 PF00020.16 027852.1_32924120_1 - 3.5e-17 62.4 41.7 2.4e-07 30.9 2.0 5.0 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region DUF3981 PF13139.4 027852.1_32924120_1 - 0.098 12.9 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3981) PHD_2 PF13831.4 148679.1_26229120_1 - 1.4e-12 46.7 10.5 3.7e-12 45.4 10.5 1.8 1 0 0 1 1 1 1 PHD-finger PHD PF00628.27 148679.1_26229120_1 - 2.6e-05 23.9 5.6 8e-05 22.3 5.6 1.9 1 0 0 1 1 1 1 PHD-finger PsbH PF00737.18 148679.1_26229120_1 - 1.4 8.5 3.3 21 4.8 0.1 2.4 2 0 0 2 2 2 0 Photosystem II 10 kDa phosphoprotein JmjC PF02373.20 148679.1_26229120_2 - 1.1e-43 148.2 0.1 2.5e-43 147.0 0.1 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.15 148679.1_26229120_2 - 1e-11 44.5 0.0 2.2e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 jmjN domain zf-HC5HC2H_2 PF13832.4 148679.1_26229120_3 - 3.4e-12 46.4 5.4 3.4e-12 46.4 5.4 2.4 3 0 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 148679.1_26229120_3 - 3.4e-09 36.7 4.4 3.4e-09 36.7 4.4 2.3 1 1 1 2 2 2 1 PHD-like zinc-binding domain LBR_tudor PF09465.8 148679.1_26229120_3 - 1e-05 25.1 2.1 0.0031 17.2 0.1 2.7 3 0 0 3 3 3 2 Lamin-B receptor of TUDOR domain 53-BP1_Tudor PF09038.8 148679.1_26229120_3 - 0.0061 16.4 0.1 1.7 8.5 0.0 2.2 1 1 1 2 2 2 2 Tumour suppressor p53-binding protein-1 Tudor DUF1442 PF07279.9 148679.1_26229120_3 - 0.0084 15.3 0.2 0.014 14.6 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1442) EMI PF07546.11 046367.1_26225120_3 - 3.7e-18 65.9 4.4 1.1e-17 64.4 4.4 1.8 1 0 0 1 1 1 1 EMI domain EGF_CA PF07645.13 046367.1_26225120_3 - 5e-07 29.7 5.2 5e-07 29.7 5.2 2.9 2 0 0 2 2 2 1 Calcium-binding EGF domain FXa_inhibition PF14670.4 046367.1_26225120_3 - 1.3e-06 28.5 7.0 1.3e-06 28.5 7.0 3.1 3 0 0 3 3 3 1 Coagulation Factor Xa inhibitory site EGF_2 PF07974.11 046367.1_26225120_3 - 8.3e-06 25.9 10.1 8.3e-06 25.9 10.1 3.5 3 0 0 3 3 3 1 EGF-like domain EGF PF00008.25 046367.1_26225120_3 - 0.0018 18.4 24.7 0.0025 17.9 9.5 3.5 3 0 0 3 3 3 2 EGF-like domain cEGF PF12662.5 046367.1_26225120_3 - 0.0052 16.6 15.1 0.021 14.6 0.3 3.5 3 0 0 3 3 3 2 Complement Clr-like EGF-like hEGF PF12661.5 046367.1_26225120_3 - 0.013 16.0 8.4 0.013 16.0 8.4 4.0 4 0 0 4 4 4 0 Human growth factor-like EGF Trimer_CC PF08954.9 046367.1_26225120_3 - 0.87 9.1 5.1 0.5 9.8 1.9 2.4 2 0 0 2 2 2 0 Trimerisation motif IPPT PF01715.15 132401.1_26225120_2 - 2.3e-15 56.9 0.3 3.6e-15 56.3 0.3 1.2 1 0 0 1 1 1 1 IPP transferase zf-C2H2_jaz PF12171.6 132401.1_26225120_2 - 1.4e-05 25.1 0.1 3.2e-05 24.0 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding IPPT PF01715.15 132401.1_26225120_3 - 1.4e-40 139.4 0.0 1.9e-40 138.9 0.0 1.1 1 0 0 1 1 1 1 IPP transferase IPT PF01745.14 132401.1_26225120_3 - 8.8e-05 21.9 0.0 0.00013 21.3 0.0 1.2 1 0 0 1 1 1 1 Isopentenyl transferase AAA_33 PF13671.4 132401.1_26225120_3 - 0.0002 21.4 0.0 0.00039 20.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.4 132401.1_26225120_3 - 0.0036 17.4 0.0 0.0062 16.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 132401.1_26225120_3 - 0.024 14.9 0.4 0.058 13.6 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.4 132401.1_26225120_3 - 0.026 14.9 0.2 0.049 14.0 0.2 1.6 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.20 132401.1_26225120_3 - 0.057 13.7 0.2 0.17 12.1 0.0 1.9 2 0 0 2 2 2 0 RNA helicase Hpr_kinase_C PF07475.10 132401.1_26225120_3 - 0.061 12.7 0.2 0.098 12.0 0.2 1.2 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain AAA_22 PF13401.4 132401.1_26225120_3 - 0.076 13.2 0.0 0.18 12.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.4 132401.1_26225120_3 - 0.081 12.4 0.2 0.19 11.1 0.2 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.15 132401.1_26225120_3 - 0.12 12.0 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.25 132401.1_26225120_3 - 0.81 10.1 3.2 0.37 11.2 0.4 1.8 2 1 0 2 2 2 0 ABC transporter TAF1_subA PF14929.4 046471.1_26224120_2 - 0.12 11.6 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 TAF RNA Polymerase I subunit A LBP_BPI_CETP PF01273.23 001081920.1_21022001_1 - 3.4e-27 94.9 1.1 5e-27 94.4 1.1 1.3 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain Apolipoprotein PF01442.16 001081920.1_21022001_1 - 0.002 18.0 0.7 0.0069 16.2 0.2 2.0 2 1 0 2 2 2 1 Apolipoprotein A1/A4/E domain DUF937 PF06078.9 001081920.1_21022001_1 - 0.018 15.5 0.3 0.037 14.5 0.1 1.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF937) FTCD_C PF04961.10 001081920.1_21022001_1 - 0.023 14.3 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase DUF4662 PF15578.4 001101245.2_06523001_1 - 2.5e-158 525.7 2.8 3.2e-158 525.4 2.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4662) CD34_antigen PF06365.10 001302937.1_06529001_3 - 0.00034 20.1 0.0 0.00058 19.4 0.0 1.2 1 0 0 1 1 1 1 CD34/Podocalyxin family DUF1180 PF06679.10 001302937.1_06529001_3 - 0.33 11.2 0.0 0.33 11.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) LRR_8 PF13855.4 001081927.2_21023001_3 - 6.7e-06 25.7 0.7 0.04 13.5 0.1 3.9 3 0 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.5 001081927.2_21023001_3 - 0.0086 16.3 6.8 7.6 7.0 0.3 4.2 3 2 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001081927.2_21023001_3 - 0.082 13.3 7.9 15 6.4 0.0 4.6 4 1 1 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.4 001081927.2_21023001_3 - 0.26 11.3 10.2 5.3 7.2 0.1 4.5 5 0 0 5 5 5 0 Leucine Rich repeat Ashwin PF15323.4 001081539.1_06528001_1 - 5.5e-80 268.4 12.9 6.9e-80 268.1 12.9 1.1 1 0 0 1 1 1 1 Developmental protein Lectin_C PF00059.19 001009059.1_39722001_1 - 8.4e-18 65.0 1.4 2.3e-17 63.6 1.4 1.8 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 001009059.1_39722001_1 - 4.2e-05 23.1 6.0 0.00014 21.5 6.0 1.7 1 1 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Chordopox_A33R PF05966.10 001009059.1_39722001_1 - 0.0013 17.9 0.2 0.0022 17.2 0.2 1.4 1 0 0 1 1 1 1 Chordopoxvirus A33R protein DUF2452 PF10504.7 001034279.2_06522001_1 - 3.5e-72 240.9 0.0 4.2e-72 240.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2452) NNMT_PNMT_TEMT PF01234.15 008890.2_32923001_1 - 2.1e-91 305.5 0.0 2.5e-91 305.3 0.0 1.0 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_23 PF13489.4 008890.2_32923001_1 - 0.011 15.5 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.10 008890.2_32923001_1 - 0.072 13.6 0.0 0.36 11.4 0.0 2.0 1 1 0 2 2 2 0 Methyltransferase domain ProSAAS PF07259.10 008890.2_32923001_1 - 0.083 12.7 0.2 0.19 11.5 0.2 1.6 1 0 0 1 1 1 0 ProSAAS precursor Methyltransf_12 PF08242.10 008890.2_32923001_1 - 0.16 12.5 0.0 0.45 11.1 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain SmAKAP PF15127.4 001076991.2_06522001_1 - 1.3e-39 135.2 0.0 1.7e-39 134.8 0.0 1.1 1 0 0 1 1 1 1 Small membrane A-kinase anchor protein fn3 PF00041.19 001081942.1_21023001_1 - 7.6e-07 29.3 0.1 1.4e-06 28.4 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III domain STG PF15809.3 001135739.1_39723001_1 - 5e-137 455.5 54.2 1.1e-123 411.9 31.9 2.3 2 1 1 3 3 3 2 Simian taste bud-specific gene product family Mucin-like PF16058.3 001135739.1_39723001_1 - 5e-05 23.2 2.6 0.0001 22.2 0.0 2.5 2 0 0 2 2 2 1 Mucin-like ChaC PF04752.10 024111.5_26224001_3 - 1.5e-66 223.7 0.0 1.9e-66 223.4 0.0 1.1 1 0 0 1 1 1 1 ChaC-like protein GGACT PF06094.10 024111.5_26224001_3 - 0.015 15.7 0.1 0.024 15.1 0.1 1.2 1 0 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like IL8 PF00048.18 011329.3_32922001_3 - 1.3e-16 60.4 3.0 1.5e-16 60.1 2.2 1.5 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like LRR_8 PF13855.4 001081771.2_21028001_3 - 1.8e-66 219.7 100.1 1e-09 37.9 7.4 15.1 10 3 5 15 15 15 13 Leucine rich repeat LRR_4 PF12799.5 001081771.2_21028001_3 - 2.5e-32 110.1 113.7 3.6e-06 27.0 4.9 16.8 10 6 6 17 17 17 13 Leucine Rich repeats (2 copies) TIR PF01582.18 001081771.2_21028001_3 - 1.3e-12 47.8 0.2 1.9e-12 47.2 0.2 1.3 1 0 0 1 1 1 1 TIR domain LRR_5 PF13306.4 001081771.2_21028001_3 - 3.6e-11 43.0 26.7 0.006 16.4 0.0 7.1 5 3 0 7 7 7 4 Leucine rich repeats (6 copies) LRR_1 PF00560.31 001081771.2_21028001_3 - 3.8e-08 32.5 87.2 1.1 9.8 0.2 21.4 21 5 2 23 23 23 6 Leucine Rich Repeat LRR_9 PF14580.4 001081771.2_21028001_3 - 7.6e-07 28.7 47.8 0.033 13.6 4.4 7.5 3 3 4 7 7 7 5 Leucine-rich repeat TIR_2 PF13676.4 001081771.2_21028001_3 - 0.0005 20.2 0.0 0.00099 19.3 0.0 1.5 1 0 0 1 1 1 1 TIR domain LRR_6 PF13516.4 001081771.2_21028001_3 - 6.2 7.0 80.9 2.2 8.4 0.2 17.7 20 0 0 20 20 20 0 Leucine Rich repeat LRR_2 PF07723.11 001081771.2_21028001_3 - 9.2 7.0 11.5 13 6.6 0.1 6.2 6 0 0 6 6 6 0 Leucine Rich Repeat TK PF00265.16 009387.2_32923001_2 - 4.5e-70 235.0 0.3 6.2e-70 234.5 0.3 1.2 1 0 0 1 1 1 1 Thymidine kinase AAA_14 PF13173.4 009387.2_32923001_2 - 0.014 15.2 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain Sod_Fe_C PF02777.16 001009022.1_39722001_1 - 2.7e-39 133.3 0.1 5.3e-39 132.4 0.0 1.5 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.20 001009022.1_39722001_1 - 3.8e-33 113.7 3.2 5.8e-33 113.1 3.2 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain CUB PF00431.18 001081324.2_32929001_1 - 1.7e-38 131.2 0.1 2.6e-25 88.8 0.0 3.1 3 0 0 3 3 3 2 CUB domain Ldl_recept_a PF00057.16 001081324.2_32929001_1 - 7.6e-07 29.1 3.5 2.5e-06 27.4 3.5 2.0 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Pou PF00157.15 011139.2_32926001_3 - 4.5e-38 129.0 0.5 1.1e-37 127.8 0.2 1.8 2 0 0 2 2 2 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 011139.2_32926001_3 - 5.6e-18 64.4 3.4 1.2e-17 63.4 3.4 1.6 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 011139.2_32926001_3 - 0.036 13.9 0.0 0.075 12.8 0.0 1.5 1 0 0 1 1 1 0 Homeobox KN domain SCAN PF02023.15 001002888.1_06529001_1 - 2.1e-32 110.7 4.3 4.3e-32 109.7 4.3 1.6 1 0 0 1 1 1 1 SCAN domain KRAB PF01352.25 001002888.1_06529001_1 - 2.7e-22 78.0 0.1 5.1e-22 77.1 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 001002888.1_06529001_1 - 5.4e-15 54.9 36.0 0.00017 21.7 1.0 7.3 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 001002888.1_06529001_1 - 5.7e-13 48.4 47.5 0.00038 20.6 5.6 6.7 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001002888.1_06529001_1 - 2.5e-06 27.7 38.9 0.14 12.9 3.4 6.6 5 0 0 5 5 5 4 C2H2-type zinc finger Rad21_Rec8 PF04824.14 001360389.1_32924001_1 - 4.6e-20 70.6 0.1 8.7e-20 69.7 0.1 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein SMC_ScpA PF02616.12 001360389.1_32924001_1 - 0.048 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Segregation and condensation protein ScpA IlvB_leader PF08049.9 001360389.1_32924001_2 - 7.8 6.3 14.9 14 5.5 14.9 1.3 1 0 0 1 1 1 0 IlvB leader peptide Rad21_Rec8_N PF04825.11 001360389.1_32924001_3 - 8.8e-06 25.7 0.0 1.2e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein IL6 PF00489.15 001082496.2_21022001_1 - 1.2e-96 321.6 4.0 1.3e-96 321.4 4.0 1.0 1 0 0 1 1 1 1 Interleukin-6/G-CSF/MGF family GCSF PF16647.3 001082496.2_21022001_1 - 4.2e-05 23.3 0.0 5.2e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Granulocyte colony-stimulating factor Sec16 PF12932.5 001082496.2_21022001_1 - 0.061 13.8 0.1 0.29 11.6 0.0 1.9 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region zf-RING_9 PF13901.4 001280498.1_39726001_3 - 5.8e-67 225.5 17.2 1e-66 224.7 17.2 1.4 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon Globin PF00042.20 001114542.1_21021001_1 - 2.2e-28 98.9 0.0 3.1e-28 98.4 0.0 1.2 1 0 0 1 1 1 1 Globin EF-hand_6 PF13405.4 174261.1_06523001_3 - 1.7e-12 46.1 0.0 0.0083 15.9 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.30 174261.1_06523001_3 - 6.3e-12 44.0 0.3 0.0093 15.3 0.0 4.6 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.4 174261.1_06523001_3 - 7.6e-08 31.9 1.2 7.1e-06 25.6 0.2 3.3 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.4 174261.1_06523001_3 - 4e-07 30.3 0.7 0.67 10.3 0.0 3.4 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 174261.1_06523001_3 - 2.8e-06 26.4 0.1 0.38 10.2 0.0 3.9 3 0 0 3 3 3 2 EF hand DUF3368 PF11848.6 174261.1_06523001_3 - 0.15 11.7 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3368) Neur_chan_memb PF02932.14 001034114.1_39724001_1 - 4.5e-107 357.4 0.0 6.9e-107 356.8 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 001034114.1_39724001_1 - 1.5e-76 256.5 2.3 1.9e-76 256.2 2.3 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF2417 PF10329.7 001034114.1_39724001_1 - 7.1 5.8 12.9 0.72 9.1 8.4 1.5 2 0 0 2 2 2 0 Region of unknown function (DUF2417) DEAD PF00270.27 001114163.1_39723001_1 - 2.4e-39 134.8 0.1 4e-39 134.0 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001114163.1_39723001_1 - 3.1e-25 88.6 0.5 9.2e-23 80.6 0.1 2.5 2 1 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.13 001114163.1_39723001_1 - 7.3e-08 32.5 0.0 1.2e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.4 001114163.1_39723001_1 - 1.2e-06 27.9 0.1 2.5e-06 26.9 0.1 1.5 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit GSHPx PF00255.17 001256230.2_39723001_2 - 8.6e-07 28.4 0.0 1.3e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase GSHPx PF00255.17 001256230.2_39723001_3 - 1.7e-10 40.3 0.1 2.6e-10 39.7 0.1 1.2 1 0 0 1 1 1 1 Glutathione peroxidase Troponin PF00992.18 001277904.1_32922001_3 - 8.5e-38 129.6 39.3 7.9e-34 116.7 30.2 3.0 2 1 1 3 3 3 2 Troponin DUF4250 PF14056.4 001277904.1_32922001_3 - 0.047 13.5 0.6 0.11 12.4 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) Peripla_BP_2 PF01497.16 001277904.1_32922001_3 - 0.46 9.9 2.7 0.87 9.0 0.8 2.0 1 1 1 2 2 2 0 Periplasmic binding protein FAM195 PF14799.4 001251932.2_39722001_3 - 2.3e-28 98.4 0.0 3.6e-28 97.8 0.0 1.3 1 0 0 1 1 1 1 FAM195 family Serpin PF00079.18 001009032.1_39724001_1 - 7.2e-57 193.2 0.0 1.1e-56 192.7 0.0 1.3 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Nuc_rec_co-act PF08815.8 001009032.1_39724001_1 - 0.031 14.0 0.4 0.13 12.0 0.2 2.1 2 0 0 2 2 2 0 Nuclear receptor coactivator IL10 PF00726.15 001135620.2_39722001_1 - 3.4e-104 345.5 0.8 3.9e-104 345.3 0.8 1.0 1 0 0 1 1 1 1 Interleukin 10 IL22 PF14565.4 001135620.2_39722001_1 - 1.2e-07 31.9 0.4 1.5e-07 31.6 0.4 1.2 1 0 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor XK-related PF09815.7 001033034.1_39726001_1 - 2e-118 395.0 17.2 2.4e-118 394.7 17.2 1.1 1 0 0 1 1 1 1 XK-related protein 7tm_1 PF00001.19 029771.3_32926001_2 - 2e-37 128.8 13.3 3e-37 128.2 13.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 029771.3_32926001_2 - 0.00068 19.0 10.1 0.001 18.4 10.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Glyco_transf_29 PF00777.16 001037297.1_39723001_1 - 2.3e-74 250.0 0.2 3.3e-74 249.5 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Dickkopf_N PF04706.10 001267802.1_21024001_2 - 8.3e-17 61.3 40.9 1.1e-16 60.8 17.2 4.2 3 1 1 4 4 4 2 Dickkopf N-terminal cysteine-rich region Sox_N PF12444.6 001009029.1_39724001_1 - 9.3e-26 90.6 0.2 9.3e-26 90.6 0.2 3.2 3 0 0 3 3 3 1 Sox developmental protein N terminal HMG_box PF00505.17 001009029.1_39724001_1 - 6.6e-25 87.2 0.7 6.6e-25 87.2 0.7 1.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001009029.1_39724001_1 - 1.6e-10 41.2 1.5 2.6e-10 40.6 0.6 1.9 2 0 0 2 2 2 1 HMG-box domain Sporozoite_P67 PF05642.9 001009029.1_39724001_3 - 0.12 10.3 0.0 0.19 9.7 0.0 1.4 1 1 0 1 1 1 0 Sporozoite P67 surface antigen FAM176 PF14851.4 001101271.2_06523001_3 - 4.1e-56 188.5 0.0 5.5e-56 188.1 0.0 1.2 1 0 0 1 1 1 1 FAM176 family Defensin_beta_2 PF13841.4 001101673.1_39721001_1 - 1.4e-08 34.9 7.9 2.1e-08 34.4 7.9 1.2 1 0 0 1 1 1 1 Beta defensin Defensin_big PF14862.4 001101673.1_39721001_1 - 3.4e-05 23.9 0.1 5.7e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 Big defensin Hen1_L PF12623.5 001101673.1_39721001_3 - 0.026 13.4 0.1 0.033 13.1 0.1 1.1 1 0 0 1 1 1 0 RNA repair, ligase-Pnkp-associating, region of Hen1 IQ PF00612.25 001008994.1_39729001_1 - 1e-139 441.3 531.0 0.00027 20.3 0.4 71.6 74 0 0 74 74 74 60 IQ calmodulin-binding motif ASH PF15780.3 001008994.1_39729001_1 - 5.2e-34 116.2 0.9 9.2e-33 112.2 0.0 3.2 3 0 0 3 3 3 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin CH PF00307.29 001008994.1_39729001_1 - 2.6e-13 50.0 10.8 2.2e-08 34.1 0.0 6.2 6 1 0 6 6 6 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001008994.1_39729001_1 - 1.8e-06 27.5 0.0 7.7e-06 25.5 0.0 2.1 1 0 0 1 1 1 1 CAMSAP CH domain DUF5036 PF16439.3 001008994.1_39729001_1 - 0.16 11.6 1.8 8.2 5.9 0.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5036) CH_2 PF06294.9 001008994.1_39729001_1 - 0.33 11.0 0.0 0.33 11.0 0.0 5.2 5 0 0 5 5 5 0 CH-like domain in sperm protein LRR_8 PF13855.4 001078150.2_06524001_1 - 5.5e-36 122.0 34.3 4.4e-12 45.4 4.5 4.1 2 2 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 001078150.2_06524001_1 - 8e-15 54.5 19.7 2.5e-07 30.7 2.3 5.0 4 1 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001078150.2_06524001_1 - 4.1e-11 42.8 0.2 8.7e-06 25.6 0.1 2.3 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001078150.2_06524001_1 - 7.4e-09 35.2 3.6 0.00016 21.1 1.7 2.2 2 0 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.31 001078150.2_06524001_1 - 2.7e-07 30.0 7.8 1.6 9.3 0.5 6.4 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_6 PF13516.4 001078150.2_06524001_1 - 8.4e-05 22.2 16.1 1.3 9.1 0.8 5.5 5 0 0 5 5 5 4 Leucine Rich repeat LRR_8 PF13855.4 001111301.1_21027001_2 - 5.4e-81 266.1 92.3 6.2e-11 41.8 13.9 14.5 9 3 4 14 14 14 14 Leucine rich repeat LRR_4 PF12799.5 001111301.1_21027001_2 - 1.5e-45 152.1 97.0 2.5e-05 24.4 1.4 15.8 8 5 9 18 18 18 17 Leucine Rich repeats (2 copies) TIR PF01582.18 001111301.1_21027001_2 - 1.9e-14 53.7 1.2 3.3e-14 52.9 1.2 1.3 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.31 001111301.1_21027001_2 - 2.6e-14 51.3 93.4 0.25 11.8 1.1 22.7 24 2 1 25 25 25 6 Leucine Rich Repeat LRR_5 PF13306.4 001111301.1_21027001_2 - 4.8e-08 32.9 26.3 0.12 12.2 0.6 7.6 4 2 3 7 7 7 5 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001111301.1_21027001_2 - 9.6e-08 31.6 37.8 0.037 13.4 3.7 7.7 3 3 2 7 7 7 5 Leucine-rich repeat TIR_2 PF13676.4 001111301.1_21027001_2 - 5.4e-05 23.3 0.1 0.00011 22.4 0.1 1.5 1 0 0 1 1 1 1 TIR domain FNIP PF05725.10 001111301.1_21027001_2 - 0.0053 16.8 21.6 0.42 10.7 0.5 7.8 7 3 1 8 8 8 2 FNIP Repeat Sec3-PIP2_bind PF15277.4 001359373.1_32928001_2 - 8.1e-27 93.1 2.0 1.6e-26 92.1 2.0 1.5 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH TPR_2 PF07719.15 001195146.1_39725001_2 - 7.5e-17 59.9 20.2 0.00039 20.2 0.0 8.0 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_8 PF13181.4 001195146.1_39725001_2 - 1.5e-16 59.0 18.2 0.01 15.8 0.0 8.2 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.4 001195146.1_39725001_2 - 1.3e-15 57.5 1.4 4.6e-05 23.7 0.0 4.2 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.26 001195146.1_39725001_2 - 1.3e-12 46.8 24.8 0.0019 17.8 0.0 7.6 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.4 001195146.1_39725001_2 - 1.5e-12 46.8 13.0 0.0016 17.9 0.1 6.4 6 0 0 6 6 6 4 TPR repeat TPR_14 PF13428.4 001195146.1_39725001_2 - 7e-12 45.0 2.1 0.00095 19.7 0.0 6.9 4 3 3 7 7 7 1 Tetratricopeptide repeat TPR_12 PF13424.4 001195146.1_39725001_2 - 1.5e-11 44.3 9.6 1.5e-05 25.1 2.0 4.9 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.4 001195146.1_39725001_2 - 1e-10 40.7 3.0 0.0014 18.4 0.0 5.1 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_17 PF13431.4 001195146.1_39725001_2 - 1.6e-10 40.5 17.0 0.018 15.3 0.0 8.1 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_16 PF13432.4 001195146.1_39725001_2 - 1.4e-06 28.7 0.3 0.23 12.1 0.0 5.0 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.4 001195146.1_39725001_2 - 1.5e-05 25.2 5.4 0.027 15.0 0.0 5.3 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_15 PF13429.4 001195146.1_39725001_2 - 1.9e-05 23.9 0.2 0.15 11.1 0.1 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat NARP1 PF12569.6 001195146.1_39725001_2 - 6e-05 22.0 2.5 0.0015 17.4 0.0 3.4 1 1 1 3 3 3 1 NMDA receptor-regulated protein 1 Cohesin_load PF10345.7 001195146.1_39725001_2 - 0.00015 20.2 1.1 0.015 13.6 0.0 3.1 2 2 1 3 3 3 1 Cohesin loading factor PUL PF08324.9 001195146.1_39725001_2 - 0.0019 17.4 0.0 0.0039 16.4 0.0 1.5 1 0 0 1 1 1 1 PUL domain TPR_10 PF13374.4 001195146.1_39725001_2 - 0.019 14.7 8.9 3.8 7.4 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat ChAPs PF09295.8 001195146.1_39725001_2 - 0.043 12.7 0.0 0.074 11.9 0.0 1.3 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) RPN7 PF10602.7 001195146.1_39725001_2 - 0.061 12.8 1.7 1.5 8.3 0.0 2.8 3 0 0 3 3 3 0 26S proteasome subunit RPN7 PPR PF01535.18 001195146.1_39725001_2 - 0.1 12.8 1.3 1.5 9.1 0.0 3.3 3 0 0 3 3 3 0 PPR repeat TPR_9 PF13371.4 001195146.1_39725001_2 - 0.21 11.7 2.5 11 6.2 0.1 4.0 5 0 0 5 5 4 0 Tetratricopeptide repeat ANAPC3 PF12895.5 001195146.1_39725001_2 - 0.87 9.7 10.4 0.78 9.8 0.1 4.3 4 1 1 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Pkinase PF00069.23 001330702.1_32929001_1 - 6.3e-142 471.5 0.3 1.9e-72 243.7 0.1 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 001330702.1_32929001_1 - 6.1e-65 218.9 0.0 1.7e-31 109.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.4 001330702.1_32929001_1 - 1.7e-11 43.8 0.0 0.00039 19.7 0.0 3.1 3 0 0 3 3 3 2 Kinase-like Kdo PF06293.12 001330702.1_32929001_1 - 5.3e-11 42.1 1.0 4.4e-08 32.6 0.1 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001330702.1_32929001_1 - 1.1e-08 35.2 0.9 0.0002 21.2 0.0 3.6 2 2 2 4 4 4 2 Phosphotransferase enzyme family Pkinase_C PF00433.22 001330702.1_32929001_1 - 1.5e-08 35.1 0.4 3.4e-08 33.9 0.4 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain FTA2 PF13095.4 001330702.1_32929001_1 - 3.5e-05 23.4 0.6 1.6 8.2 0.0 3.2 3 0 0 3 3 3 3 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.20 001330702.1_32929001_1 - 8.8e-05 22.0 2.2 0.0014 18.1 0.2 2.3 2 0 0 2 2 2 1 RIO1 family Choline_kinase PF01633.18 001330702.1_32929001_1 - 0.029 13.8 1.0 0.14 11.6 0.0 2.4 3 0 0 3 3 3 0 Choline/ethanolamine kinase SR-25 PF10500.7 001330702.1_32929001_1 - 0.31 10.5 7.4 0.52 9.7 7.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4187 PF13821.4 001330702.1_32929001_2 - 0.2 11.3 3.2 0.43 10.3 3.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) Peptidase_M2 PF01401.16 001008995.3_39729001_3 - 0 1731.7 7.1 1.5e-263 875.5 1.0 2.0 2 0 0 2 2 2 2 Angiotensin-converting enzyme Imm-NTF2-2 PF15631.4 001008995.3_39729001_3 - 0.081 13.1 0.1 2.4 8.3 0.0 2.3 2 0 0 2 2 2 0 NTF2 fold immunity protein APG6 PF04111.10 001279930.1_39725001_2 - 0.0003 20.2 24.2 0.0003 20.2 24.2 2.8 1 1 1 2 2 1 1 Autophagy protein Apg6 AAA_13 PF13166.4 001279930.1_39725001_2 - 0.048 12.2 24.0 0.079 11.5 24.0 1.2 1 0 0 1 1 1 0 AAA domain EzrA PF06160.10 001279930.1_39725001_2 - 0.08 11.0 27.4 0.42 8.6 7.5 2.4 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA NPV_P10 PF05531.10 001279930.1_39725001_2 - 0.55 10.6 16.5 0.34 11.3 4.7 3.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Fez1 PF06818.13 001279930.1_39725001_2 - 1.7 8.9 42.8 1.7e+02 2.4 27.8 3.4 1 1 1 2 2 1 0 Fez1 Baculo_PEP_C PF04513.10 001279930.1_39725001_2 - 2.6 7.9 20.5 5 7.0 4.0 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF745 PF05335.11 001279930.1_39725001_2 - 3.2 7.3 24.8 3.5 7.2 5.3 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF745) SlyX PF04102.10 001279930.1_39725001_2 - 4.8 7.7 43.9 0.25 11.8 6.8 4.3 5 0 0 5 5 5 0 SlyX DUF724 PF05266.12 001279930.1_39725001_2 - 5.6 6.6 26.6 3.1 7.5 3.2 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF724) PKcGMP_CC PF16808.3 001279930.1_39725001_2 - 8.2 6.2 20.3 0.28 11.0 0.5 4.3 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Reo_sigmaC PF04582.10 001279930.1_39725001_2 - 8.8 5.5 10.0 2.1 7.5 3.3 2.3 1 1 1 2 2 2 0 Reovirus sigma C capsid protein IL13 PF03487.11 001143791.1_21021001_1 - 1.6e-59 199.3 0.9 1.8e-59 199.1 0.9 1.0 1 0 0 1 1 1 1 Interleukin-13 IL4 PF00727.16 001143791.1_21021001_1 - 0.0043 17.2 3.6 0.009 16.1 3.6 1.4 1 1 0 1 1 1 1 Interleukin 4 Pkinase PF00069.23 001101884.2_06524001_1 - 1e-36 126.6 0.0 1.3e-36 126.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001101884.2_06524001_1 - 1.2e-31 109.9 0.0 1.5e-31 109.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RHIM PF12721.5 001101884.2_06524001_1 - 4.4e-09 36.6 0.3 2.6e-08 34.0 0.0 2.5 2 0 0 2 2 2 1 RIP homotypic interaction motif APH PF01636.21 001101884.2_06524001_1 - 0.00076 19.3 0.1 0.002 17.9 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Telomere_Sde2 PF13019.4 001101884.2_06524001_1 - 0.16 11.6 0.1 0.34 10.6 0.1 1.4 1 0 0 1 1 1 0 Telomere stability and silencing Pkinase_Tyr PF07714.15 001101884.2_06524001_2 - 0.00031 20.0 0.0 0.00046 19.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Humanin PF15040.4 001193632.1_39723001_1 - 4e-16 58.1 0.1 6.5e-16 57.4 0.1 1.3 1 0 0 1 1 1 1 Humanin family Peptidase_C14 PF00656.20 001081842.1_21023001_1 - 3.9e-53 180.8 0.0 5.4e-53 180.3 0.0 1.2 1 0 0 1 1 1 1 Caspase domain CARD PF00619.19 001081842.1_21023001_1 - 1.9e-28 98.2 0.2 7.7e-28 96.2 0.2 1.9 2 0 0 2 2 2 1 Caspase recruitment domain ANF_receptor PF01094.26 001252403.1_32929001_2 - 2.2e-70 237.4 0.1 2.5e-69 233.9 0.0 2.1 2 0 0 2 2 2 1 Receptor family ligand binding region Lig_chan PF00060.24 001252403.1_32929001_2 - 4.4e-60 201.7 0.1 6.8e-60 201.1 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 001252403.1_32929001_2 - 4.8e-44 149.1 0.0 9.6e-44 148.1 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001252403.1_32929001_2 - 1.2e-22 80.3 0.0 2.3e-22 79.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DUF659 PF04937.13 001252403.1_32929001_2 - 0.15 11.8 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) zf-Di19 PF05605.10 001127506.1_39722001_1 - 1.7e-16 60.1 2.0 1.7e-16 60.1 2.0 3.7 2 1 0 2 2 1 1 Drought induced 19 protein (Di19), zinc-binding zf-RING_UBOX PF13445.4 001127506.1_39722001_1 - 1.5e-09 37.6 9.4 1.5e-09 37.6 9.4 3.3 3 1 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001127506.1_39722001_1 - 2.9e-08 33.3 11.5 2.9e-08 33.3 11.5 3.7 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001127506.1_39722001_1 - 4.6e-08 32.7 9.6 4.6e-08 32.7 9.6 4.1 3 2 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001127506.1_39722001_1 - 1.6e-07 30.9 12.8 1.6e-07 30.9 12.8 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001127506.1_39722001_1 - 3.1e-07 30.4 11.2 3.1e-07 30.4 11.2 3.6 3 1 1 4 4 4 1 Ring finger domain zf-C3HC4_4 PF15227.4 001127506.1_39722001_1 - 4.6e-07 29.8 13.5 4.6e-07 29.8 13.5 3.6 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 001127506.1_39722001_1 - 6.1e-07 29.2 11.1 6.1e-07 29.2 11.1 3.6 3 1 0 3 3 3 1 zinc-RING finger domain zf-RING_6 PF14835.4 001127506.1_39722001_1 - 0.00018 21.2 4.4 0.00018 21.2 4.4 2.4 2 1 0 2 2 2 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 001127506.1_39722001_1 - 0.00066 19.4 10.7 0.00066 19.4 10.7 3.5 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 U-box PF04564.13 001127506.1_39722001_1 - 0.005 16.8 0.0 0.014 15.5 0.0 1.8 1 0 0 1 1 1 1 U-box domain DND1_DSRM PF14709.5 001127506.1_39722001_1 - 0.087 13.0 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 zf-C2H2_4 PF13894.4 001127506.1_39722001_1 - 0.18 12.6 1.2 0.18 12.6 1.2 5.4 5 2 1 6 6 6 0 C2H2-type zinc finger zf-4CXXC_R1 PF10497.7 001127506.1_39722001_1 - 0.44 10.7 12.7 2 8.6 5.1 3.2 2 1 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-RING_4 PF14570.4 001127506.1_39722001_1 - 3.1 7.5 21.7 0.58 9.8 4.6 4.8 5 0 0 5 5 5 0 RING/Ubox like zinc-binding domain His_Phos_2 PF00328.20 001098866.1_06525001_3 - 5e-33 114.9 0.0 3.3e-31 108.9 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) LRR_4 PF12799.5 001328308.1_39724001_1 - 2.1e-12 46.9 6.2 0.081 13.2 0.0 5.8 4 2 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 001328308.1_39724001_1 - 3.4e-08 32.8 13.5 1.5 8.9 0.0 8.3 8 1 1 9 9 9 3 Leucine Rich repeat LRR_1 PF00560.31 001328308.1_39724001_1 - 1.7e-05 24.5 10.0 4.7 7.9 0.2 7.7 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_8 PF13855.4 001328308.1_39724001_1 - 0.0027 17.3 11.0 1.4 8.6 0.1 5.3 4 2 1 5 5 5 2 Leucine rich repeat Ste50p-SAM PF09235.8 001328308.1_39724001_1 - 0.21 11.7 2.5 7.1 6.8 0.1 3.7 4 0 0 4 4 4 0 Ste50p, sterile alpha motif F-box-like PF12937.5 001328308.1_39724001_3 - 1.5e-07 31.1 0.1 3e-07 30.1 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001328308.1_39724001_3 - 2.1e-05 24.2 0.5 4.4e-05 23.1 0.0 1.8 2 0 0 2 2 2 1 F-box domain Itfg2 PF15907.3 001280328.1_39725001_2 - 5.4e-159 528.6 0.0 6.3e-156 518.5 0.0 2.0 1 1 1 2 2 2 2 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_Mid PF14783.4 001280328.1_39725001_2 - 1.1e-13 51.1 0.1 0.0027 17.6 0.0 3.8 4 0 0 4 4 4 3 Ciliary BBSome complex subunit 2, middle region FG-GAP PF01839.21 001280328.1_39725001_2 - 2.1e-05 24.4 1.4 0.22 11.6 0.1 2.9 2 0 0 2 2 2 2 FG-GAP repeat VCBS PF13517.4 001280328.1_39725001_2 - 2.2e-05 24.8 5.0 0.38 11.3 0.3 3.8 4 0 0 4 4 4 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella BBS1 PF14779.4 001280328.1_39725001_2 - 0.23 10.7 2.5 5.7 6.1 0.1 3.3 3 1 0 4 4 4 0 Ciliary BBSome complex subunit 1 Arf PF00025.19 001280307.1_39724001_1 - 7.4e-78 259.9 0.1 1.1e-77 259.3 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001280307.1_39724001_1 - 8.5e-14 51.2 0.0 1.2e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 001280307.1_39724001_1 - 3.7e-13 49.6 0.0 5.3e-13 49.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001280307.1_39724001_1 - 9.8e-12 44.6 0.0 1.4e-11 44.1 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 001280307.1_39724001_1 - 3.5e-10 39.5 1.1 5.7e-07 28.9 0.2 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 001280307.1_39724001_1 - 7.4e-10 38.4 0.0 1e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001280307.1_39724001_1 - 0.00019 21.4 0.0 0.00028 20.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 001280307.1_39724001_1 - 0.058 12.6 0.5 0.13 11.5 0.1 1.6 2 0 0 2 2 2 0 6-phosphofructo-2-kinase bZIP_1 PF00170.19 009716.3_32924001_1 - 3e-17 62.3 15.6 5.1e-17 61.6 15.6 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 009716.3_32924001_1 - 1.7e-07 31.0 12.5 3.6e-07 30.0 12.5 1.6 1 0 0 1 1 1 1 Basic region leucine zipper Fez1 PF06818.13 009716.3_32924001_1 - 0.006 16.9 5.0 0.0086 16.4 5.0 1.1 1 0 0 1 1 1 1 Fez1 DUF4407 PF14362.4 009716.3_32924001_1 - 0.0068 15.7 3.1 0.0094 15.2 3.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) OmpH PF03938.12 009716.3_32924001_1 - 0.24 11.2 8.9 0.36 10.7 8.9 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Laminin_II PF06009.10 009716.3_32924001_1 - 0.55 10.1 6.7 0.82 9.6 6.7 1.2 1 0 0 1 1 1 0 Laminin Domain II Nop53 PF07767.9 009716.3_32924001_1 - 0.63 9.3 12.5 0.92 8.8 12.5 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF3450 PF11932.6 009716.3_32924001_1 - 0.63 9.2 9.8 0.94 8.6 9.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Baculo_F PF12259.6 009716.3_32924001_1 - 0.66 8.3 4.1 0.89 7.9 4.1 1.1 1 0 0 1 1 1 0 Baculovirus F protein Taxilin PF09728.7 009716.3_32924001_1 - 1 8.4 17.5 0.3 10.2 14.6 1.4 2 0 0 2 2 2 0 Myosin-like coiled-coil protein bZIP_Maf PF03131.15 009716.3_32924001_1 - 1.4 9.3 9.1 2.3 8.7 9.1 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor AAA_13 PF13166.4 009716.3_32924001_1 - 1.5 7.2 10.9 1.9 6.9 10.9 1.0 1 0 0 1 1 1 0 AAA domain APG6 PF04111.10 009716.3_32924001_1 - 1.6 7.9 10.6 2.3 7.4 10.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.12 009716.3_32924001_1 - 2.3 7.8 9.9 4 7.1 9.9 1.2 1 0 0 1 1 1 0 IncA protein HemX PF04375.12 009716.3_32924001_1 - 5.4 6.1 7.1 7.3 5.6 7.1 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF724 PF05266.12 009716.3_32924001_1 - 5.9 6.5 15.4 11 5.7 13.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DivIC PF04977.13 009716.3_32924001_1 - 6.1 6.5 10.0 3.4 7.4 6.9 1.8 1 1 1 2 2 2 0 Septum formation initiator LRR_8 PF13855.4 001113404.1_32923001_3 - 9.6e-17 60.4 3.6 1.6e-06 27.7 0.1 4.2 2 2 2 4 4 4 4 Leucine rich repeat LRR_5 PF13306.4 001113404.1_32923001_3 - 9.7e-11 41.6 0.5 6.4e-05 22.8 0.0 2.2 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) Ets PF00178.20 001302152.1_32927001_2 - 8.5e-36 122.2 0.5 1.6e-35 121.3 0.5 1.5 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 001302152.1_32927001_2 - 3.1e-25 87.8 0.0 5.7e-25 87.0 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Pex14_N PF04695.11 001302152.1_32927001_2 - 0.39 11.3 3.2 0.7 10.5 0.3 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Hormone_recep PF00104.28 009697.3_32929001_1 - 3.6e-39 134.4 0.1 5.4e-39 133.8 0.1 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 009697.3_32929001_1 - 5.3e-31 106.8 16.3 1.3e-30 105.5 16.3 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) DUF3915 PF13054.4 009697.3_32929001_2 - 3e-06 27.1 1.3 5.7e-06 26.2 1.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) DUF3915 PF13054.4 009697.3_32929001_3 - 0.0065 16.3 2.9 0.0065 16.3 2.9 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3915) LBP_BPI_CETP_C PF02886.15 001319873.1_39725001_1 - 8.1e-77 257.7 3.9 2e-57 194.2 0.5 2.3 1 1 1 2 2 2 2 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.23 001319873.1_39725001_1 - 2.9e-05 23.6 0.1 0.0002 20.9 0.1 2.3 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain Mg_trans_NIPA PF05653.12 001008894.2_26226001_3 - 8.9e-127 422.1 19.5 3.7e-125 416.8 19.5 2.1 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.18 001008894.2_26226001_3 - 5.1e-07 29.8 2.3 5.1e-07 29.8 2.3 3.9 3 1 0 4 4 4 1 EamA-like transporter family PH PF00169.27 001194346.2_29623001_3 - 6.5e-10 39.3 0.0 9.6e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 PH domain DUF4510 PF14971.4 001194346.2_29623001_3 - 0.068 13.4 2.6 3.1 8.0 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4510) DUF4392 PF14336.4 001280511.1_39727001_1 - 7.3e-106 353.7 0.0 9.9e-106 353.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) DUF1445 PF07286.10 001280511.1_39727001_1 - 1.9e-49 167.2 0.0 2.8e-49 166.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) SNN_linker PF09050.8 001280511.1_39727001_1 - 0.11 12.2 0.2 0.5 10.1 0.2 2.2 1 0 0 1 1 1 0 Stannin unstructured linker DUF4392 PF14336.4 001102367.2_26226001_1 - 3.6e-123 410.5 0.0 4.5e-123 410.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) DUF1445 PF07286.10 001102367.2_26226001_1 - 3.9e-44 149.9 0.0 6.4e-44 149.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) DUF4392 PF14336.4 001131940.1_43526001_1 - 1.4e-123 411.9 0.0 1.8e-123 411.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) DUF1445 PF07286.10 001131940.1_43526001_1 - 4.4e-45 153.0 0.0 8e-27 93.8 0.0 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF1445) Ribosomal_L22e PF01776.15 102292.1_32925120_3 - 8.1e-45 151.6 4.6 4.9e-39 132.9 2.5 2.2 2 0 0 2 2 2 2 Ribosomal L22e protein family Motilin_assoc PF04643.10 016362.4_26223001_2 - 9.7e-33 111.7 0.3 1.5e-32 111.1 0.3 1.3 1 0 0 1 1 1 1 Motilin/ghrelin-associated peptide Motilin_ghrelin PF04644.10 016362.4_26223001_2 - 3.1e-11 42.8 5.1 6.4e-11 41.8 5.1 1.5 1 0 0 1 1 1 1 Motilin/ghrelin Sema PF01403.17 001350120.1_26229001_1 - 2.3e-148 494.4 0.0 3e-148 494.0 0.0 1.1 1 0 0 1 1 1 1 Sema domain I-set PF07679.14 001350120.1_26229001_1 - 1.1e-05 25.3 0.1 2.3e-05 24.2 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001350120.1_26229001_1 - 4.8e-05 23.8 0.0 0.00028 21.3 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain PSI PF01437.23 001350120.1_26229001_1 - 0.0014 18.9 7.9 0.0045 17.4 7.9 1.9 1 0 0 1 1 1 1 Plexin repeat Ig_2 PF13895.4 001350120.1_26229001_1 - 0.023 14.9 0.0 0.06 13.6 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain ig PF00047.23 001350120.1_26229001_1 - 0.032 14.2 0.0 0.11 12.6 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.15 001350120.1_26229001_1 - 0.044 13.8 0.0 0.16 12.0 0.0 2.0 1 1 0 1 1 1 0 Immunoglobulin V-set domain KAP_NTPase PF07693.12 001348731.1_26229001_2 - 1.7e-109 365.9 0.0 2.3e-109 365.5 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain Ank_2 PF12796.5 001348731.1_26229001_2 - 1e-72 240.6 3.1 1.4e-13 51.1 0.0 6.5 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001348731.1_26229001_2 - 1.9e-60 199.7 6.5 5.8e-11 42.3 0.1 9.8 2 1 6 9 9 9 9 Ankyrin repeats (many copies) Ank_4 PF13637.4 001348731.1_26229001_2 - 2.9e-57 190.2 0.2 4.7e-08 33.3 0.1 9.2 3 2 8 11 11 11 10 Ankyrin repeats (many copies) Ank PF00023.28 001348731.1_26229001_2 - 1.2e-55 183.4 1.4 2.6e-06 27.5 0.0 11.7 11 0 0 11 11 11 10 Ankyrin repeat Ank_3 PF13606.4 001348731.1_26229001_2 - 3.2e-48 156.0 1.2 5.4e-06 26.2 0.0 11.8 11 0 0 11 11 11 10 Ankyrin repeat NACHT PF05729.10 001348731.1_26229001_2 - 0.0028 17.5 0.8 0.089 12.6 0.1 2.5 2 0 0 2 2 2 1 NACHT domain SAM_1 PF00536.28 001348731.1_26229001_2 - 0.0058 16.9 0.0 0.021 15.1 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) TctB PF07331.9 001348731.1_26229001_2 - 2.8 8.1 9.1 8.1 6.6 1.2 2.3 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family fn3 PF00041.19 001204314.2_26229001_1 - 0.0056 16.9 0.0 0.025 14.8 0.0 2.1 2 0 0 2 2 2 1 Fibronectin type III domain RNase_Zc3h12a PF11977.6 025079.2_26226001_1 - 4.9e-65 217.9 0.0 2.4e-64 215.7 0.0 1.9 2 0 0 2 2 2 1 Zc3h12a-like Ribonuclease NYN domain zf-CCCH_2 PF14608.4 025079.2_26226001_1 - 2.2 8.7 7.9 5.6 7.5 7.9 1.7 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger NGF PF00243.16 001270637.1_45728001_1 - 3.4e-47 159.2 2.3 5.5e-47 158.5 2.3 1.3 1 0 0 1 1 1 1 Nerve growth factor family Pkinase_Tyr PF07714.15 001107350.1_45729001_2 - 1.1e-51 175.5 0.0 1.6e-51 175.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001107350.1_45729001_2 - 1.7e-51 175.0 0.1 2.8e-51 174.3 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Death PF00531.20 001107350.1_45729001_2 - 4.3e-22 77.9 0.6 7.7e-22 77.1 0.6 1.4 1 0 0 1 1 1 1 Death domain RHIM PF12721.5 001107350.1_45729001_2 - 5.6e-05 23.4 0.0 0.00018 21.8 0.0 1.9 1 0 0 1 1 1 1 RIP homotypic interaction motif Kdo PF06293.12 001107350.1_45729001_2 - 0.0024 17.1 0.2 0.0042 16.3 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001107350.1_45729001_2 - 0.0028 16.9 0.0 0.0044 16.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 001107350.1_45729001_2 - 0.0057 16.1 0.8 0.01 15.3 0.8 1.3 1 0 0 1 1 1 1 RIO1 family Endothelin PF00322.15 012548.2_45723001_1 - 3.5e-22 77.5 17.5 5e-21 73.9 3.6 2.8 3 0 0 3 3 3 2 Endothelin family PHD_3 PF13922.4 012548.2_45723001_1 - 0.071 13.4 1.9 0.51 10.6 0.0 2.3 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx Pkinase_Tyr PF07714.15 031507.1_45729001_1 - 2e-88 295.9 0.0 3e-88 295.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 031507.1_45729001_1 - 2.2e-59 198.3 0.8 1.1e-29 102.7 1.2 2.4 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.4 031507.1_45729001_1 - 3.1e-52 175.7 83.3 3e-47 159.6 31.1 4.0 2 1 1 3 3 3 2 Growth factor receptor domain IV Pkinase PF00069.23 031507.1_45729001_1 - 1.4e-39 135.9 0.0 2.3e-39 135.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.18 031507.1_45729001_1 - 2.3e-32 111.8 91.2 2.3e-28 98.8 40.0 4.3 2 1 1 3 3 3 2 Furin-like cysteine rich region APH PF01636.21 031507.1_45729001_1 - 0.035 13.9 0.0 0.06 13.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.4 031507.1_45729001_1 - 0.068 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Kisspeptin PF15152.4 001306104.1_39522001_2 - 1.1e-36 125.3 1.0 2.5e-36 124.2 1.0 1.7 1 0 0 1 1 1 1 Kisspeptin FAM180 PF15173.4 058175.2_26227001_1 - 0.13 12.1 0.1 0.2 11.4 0.1 1.2 1 0 0 1 1 1 0 FAM180 family VWA PF00092.26 058175.2_26227001_2 - 1.1e-61 208.0 0.1 8.3e-31 107.5 0.1 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain Collagen PF01391.16 058175.2_26227001_2 - 7e-50 166.5 218.5 7.3e-10 38.3 34.6 7.6 2 1 4 6 6 6 4 Collagen triple helix repeat (20 copies) VWA_2 PF13519.4 058175.2_26227001_2 - 9.3e-26 90.5 0.0 2.8e-13 50.3 0.0 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_3 PF13768.4 058175.2_26227001_2 - 0.0048 16.7 0.4 1.7 8.4 0.1 3.4 3 1 0 3 3 3 2 von Willebrand factor type A domain Trypsin PF00089.24 002774.3_26224001_2 - 3.8e-72 242.6 0.2 4.7e-72 242.2 0.2 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 002774.3_26224001_2 - 1.2e-06 29.4 0.0 2.3e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 002774.3_26224001_2 - 3.5e-06 27.2 0.0 5.8e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) zf-H2C2_2 PF13465.4 010278.2_32926001_2 - 2e-26 91.0 39.0 4.8e-06 26.7 2.0 7.2 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 010278.2_32926001_2 - 3.4e-26 90.1 42.9 2.4e-05 24.4 1.0 7.0 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 010278.2_32926001_2 - 5.6e-20 70.2 41.4 0.0021 18.6 0.8 7.0 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 010278.2_32926001_2 - 1.2e-12 47.7 13.9 0.034 14.3 0.0 6.6 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 010278.2_32926001_2 - 3.4e-11 42.7 36.3 0.0059 16.4 1.6 6.6 6 0 0 6 6 6 6 C2H2-type zinc finger zf-met PF12874.5 010278.2_32926001_2 - 6.6e-09 35.7 18.0 0.0073 16.5 0.5 5.4 5 0 0 5 5 5 3 Zinc-finger of C2H2 type Ta0938 PF11494.6 010278.2_32926001_2 - 0.00063 19.8 0.6 0.11 12.7 0.0 2.5 2 0 0 2 2 2 1 Ta0938 zf-BED PF02892.13 010278.2_32926001_2 - 0.24 11.4 32.3 0.68 9.9 5.3 5.3 4 1 2 6 6 6 0 BED zinc finger zf-Di19 PF05605.10 010278.2_32926001_2 - 0.46 10.7 21.1 0.83 9.9 3.4 4.3 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-CHCC PF10276.7 010278.2_32926001_2 - 0.49 10.4 9.5 1.5 8.8 0.3 3.9 4 0 0 4 4 4 0 Zinc-finger domain zf-C2HC_2 PF13913.4 010278.2_32926001_2 - 0.74 9.7 20.1 4.3 7.2 1.0 5.3 5 0 0 5 5 5 0 zinc-finger of a C2HC-type BolA PF01722.16 010278.2_32926001_2 - 2.6 8.3 6.5 3.7 7.8 0.5 3.0 2 1 0 2 2 2 0 BolA-like protein GAGA PF09237.9 010278.2_32926001_2 - 3 7.6 6.2 22 4.8 0.1 3.9 2 2 2 4 4 4 0 GAGA factor zinc_ribbon_15 PF17032.3 010278.2_32926001_2 - 3.4 8.4 12.6 12 6.6 1.1 3.3 1 1 2 3 3 3 0 zinc-ribbon family HypA PF01155.17 010278.2_32926001_2 - 8.6 6.3 11.3 84 3.1 0.5 3.1 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.8 010278.2_32926001_2 - 8.6 6.4 24.1 2.9 8.0 2.4 5.3 4 2 2 6 6 6 0 Zinc ribbon domain Ank_5 PF13857.4 001301368.1_32925001_1 - 1.9e-18 66.1 5.1 7.7e-09 35.5 0.2 4.0 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 001301368.1_32925001_1 - 6.3e-18 64.8 3.0 3.4e-08 33.7 0.0 4.1 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.5 001301368.1_32925001_1 - 7.3e-17 61.6 0.7 1.3e-08 35.1 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 001301368.1_32925001_1 - 3.5e-11 42.9 3.5 0.02 15.2 0.2 4.9 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.4 001301368.1_32925001_1 - 2.7e-10 39.4 1.2 0.0074 16.6 0.1 4.8 5 0 0 5 5 5 3 Ankyrin repeat DUF1843 PF08898.8 001301368.1_32925001_1 - 0.046 14.1 0.0 0.25 11.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) Trypsin PF00089.24 013151.2_45726001_3 - 2.8e-67 226.7 0.0 4e-67 226.1 0.0 1.3 1 0 0 1 1 1 1 Trypsin Kringle PF00051.16 013151.2_45726001_3 - 1.9e-44 149.7 23.7 5.8e-23 80.9 5.0 3.0 3 0 0 3 3 3 2 Kringle domain fn1 PF00039.16 013151.2_45726001_3 - 2.5e-10 40.2 4.7 2.5e-10 40.2 4.7 2.2 2 0 0 2 2 2 1 Fibronectin type I domain EGF PF00008.25 013151.2_45726001_3 - 6.7e-06 26.2 5.8 6.7e-06 26.2 5.8 4.2 5 0 0 5 5 5 1 EGF-like domain DUF1986 PF09342.9 013151.2_45726001_3 - 0.0012 19.1 0.0 0.0022 18.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 013151.2_45726001_3 - 0.0048 17.6 0.0 0.012 16.4 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain Ins145_P3_rec PF08709.9 002224.3_26229001_3 - 5.5e-97 323.0 0.2 4e-96 320.2 0.3 2.3 2 0 0 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RYDR_ITPR PF01365.19 002224.3_26229001_3 - 3.8e-73 245.1 16.6 2.2e-63 213.3 1.8 3.7 4 0 0 4 4 4 2 RIH domain MIR PF02815.17 002224.3_26229001_3 - 1.4e-68 230.2 0.1 7.4e-63 211.6 0.0 2.7 2 0 0 2 2 2 2 MIR domain RIH_assoc PF08454.9 002224.3_26229001_3 - 2.2e-31 107.5 5.6 2.2e-31 107.5 5.6 6.8 7 1 0 7 7 7 2 RyR and IP3R Homology associated Ion_trans PF00520.29 002224.3_26229001_3 - 1.4e-15 57.1 13.2 3.3e-15 55.9 13.2 1.6 1 0 0 1 1 1 1 Ion transport protein DUF1041 PF06292.15 002224.3_26229001_3 - 0.01 16.0 0.4 3.5 7.9 0.1 3.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1041) HLH PF00010.24 017826.2_26225001_3 - 2.1e-09 37.0 0.2 4.1e-09 36.1 0.2 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Luteo_PO PF04662.11 017826.2_26225001_3 - 0.033 13.7 0.0 0.093 12.3 0.0 1.7 2 0 0 2 2 2 0 Luteovirus P0 protein POM121 PF15229.4 017826.2_26225001_3 - 0.22 11.1 1.7 0.47 10.0 1.7 1.5 1 0 0 1 1 1 0 POM121 family Transposase_1 PF01359.16 001243723.1_26224001_2 - 3.8e-37 125.9 0.2 8.3e-37 124.8 0.2 1.6 1 0 0 1 1 1 1 Transposase (partial DDE domain) Pre-SET PF05033.14 001243723.1_26224001_2 - 1.5e-12 48.0 2.2 4.3e-12 46.5 2.2 1.8 1 0 0 1 1 1 1 Pre-SET motif HTH_32 PF13565.4 001243723.1_26224001_2 - 8.2e-06 26.2 0.0 2.6e-05 24.6 0.0 1.9 1 0 0 1 1 1 1 Homeodomain-like domain DDE_3 PF13358.4 001243723.1_26224001_2 - 0.00015 21.4 0.2 0.00067 19.3 0.2 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_23 PF13384.4 001243723.1_26224001_2 - 0.001 18.7 0.1 0.11 12.2 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.16 001243723.1_26224001_2 - 0.0012 18.9 0.2 0.0027 17.8 0.2 1.6 1 0 0 1 1 1 1 Transposase HTH_28 PF13518.4 001243723.1_26224001_2 - 0.0046 16.9 0.1 0.64 10.1 0.0 2.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_38 PF13936.4 001243723.1_26224001_2 - 0.0076 15.9 0.0 0.023 14.4 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_11 PF08279.10 001243723.1_26224001_2 - 0.0083 15.9 0.1 0.029 14.2 0.1 1.9 2 0 0 2 2 2 1 HTH domain HTH_24 PF13412.4 001243723.1_26224001_2 - 0.0097 15.3 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_5 PF01022.18 001243723.1_26224001_2 - 0.013 15.2 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family SET PF00856.26 001243723.1_26224001_2 - 0.023 15.0 0.0 0.046 14.0 0.0 1.7 2 0 0 2 2 2 0 SET domain HTH_Tnp_IS630 PF01710.14 001243723.1_26224001_2 - 0.024 14.6 0.1 0.051 13.5 0.1 1.5 1 0 0 1 1 1 0 Transposase Phage_pRha PF09669.8 001243723.1_26224001_2 - 0.026 14.9 0.8 0.068 13.6 0.3 2.0 2 0 0 2 2 1 0 Phage regulatory protein Rha (Phage_pRha) HTH_29 PF13551.4 001243723.1_26224001_2 - 0.038 13.9 0.0 9.9 6.1 0.0 2.6 1 1 1 2 2 2 0 Winged helix-turn helix DPCD PF14913.4 001243723.1_26224001_2 - 0.051 12.8 0.1 0.094 11.9 0.1 1.3 1 0 0 1 1 1 0 DPCD protein family Fe_dep_repress PF01325.17 001243723.1_26224001_2 - 0.069 13.2 0.0 0.54 10.4 0.0 2.1 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain MarR_2 PF12802.5 001243723.1_26224001_2 - 0.085 12.6 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 MarR family IF2_N PF04760.13 001243723.1_26224001_2 - 0.17 11.6 0.1 1.5 8.6 0.0 2.4 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region IRK PF01007.18 001260508.1_26229001_1 - 6.6e-81 271.7 1.2 9.5e-81 271.2 1.2 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel IRK PF01007.18 001260508.1_26229001_3 - 7.4e-16 57.9 0.0 1.2e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel Pkinase PF00069.23 153498.3_26229001_1 - 4.7e-79 265.3 0.0 6.1e-79 265.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 153498.3_26229001_1 - 6.8e-37 127.0 0.0 9.2e-37 126.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 153498.3_26229001_1 - 1.5e-07 30.9 0.0 3e-07 29.9 0.0 1.5 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.12 153498.3_26229001_1 - 0.0031 16.8 0.0 0.0054 16.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 153498.3_26229001_1 - 0.015 14.8 0.1 0.026 14.0 0.1 1.3 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.23 001134420.1_26227001_2 - 1.5e-46 158.8 0.0 7.2e-25 87.7 0.1 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.15 001134420.1_26227001_2 - 4.3e-15 55.6 0.0 4.5e-12 45.7 0.1 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.21 001134420.1_26227001_2 - 0.059 13.2 0.0 0.22 11.3 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family BTB PF00651.29 009744.4_32928001_2 - 2.5e-27 95.2 0.2 4e-27 94.5 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 009744.4_32928001_2 - 5.2e-23 80.3 49.2 1.6e-06 28.2 0.5 6.6 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.24 009744.4_32928001_2 - 5.1e-17 61.2 57.0 5.9e-05 23.2 0.3 7.3 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-met PF12874.5 009744.4_32928001_2 - 3.1e-10 40.0 34.9 0.00045 20.4 0.1 7.1 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.4 009744.4_32928001_2 - 5e-09 36.1 54.0 0.021 15.5 1.1 7.7 7 0 0 7 7 7 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 009744.4_32928001_2 - 2.8e-05 24.2 16.5 0.25 11.6 1.2 5.7 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 009744.4_32928001_2 - 0.014 15.2 39.0 0.036 13.9 0.0 7.1 7 0 0 7 7 7 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 009744.4_32928001_2 - 0.33 11.0 29.7 0.038 14.0 0.8 5.8 4 3 1 5 5 5 0 Zinc ribbon domain DUF3268 PF11672.6 009744.4_32928001_2 - 3.8 7.7 13.7 2.1 8.6 0.3 3.8 3 1 1 4 4 4 0 zinc-finger-containing domain GAGA PF09237.9 009744.4_32928001_2 - 9.8 5.9 17.3 8.4 6.2 0.0 5.0 1 1 4 5 5 5 0 GAGA factor Annexin PF00191.18 001278409.1_26226001_2 - 6.7e-102 333.5 12.4 7.7e-26 89.8 0.3 4.8 5 0 0 5 5 5 4 Annexin Peptidase_M10 PF00413.22 008608.4_32928001_2 - 1.2e-58 197.3 0.0 1.9e-58 196.7 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 008608.4_32928001_2 - 1.2e-54 181.9 17.5 1.1e-13 50.7 0.8 4.8 4 0 0 4 4 4 4 Hemopexin DUF3377 PF11857.6 008608.4_32928001_2 - 3.2e-24 84.5 0.0 6.4e-24 83.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) PG_binding_1 PF01471.16 008608.4_32928001_2 - 5.7e-10 39.1 0.2 1.1e-09 38.2 0.2 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 008608.4_32928001_2 - 0.0051 16.3 0.6 0.8 9.2 0.0 2.2 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) Peptidase_M54 PF07998.9 008608.4_32928001_2 - 0.026 14.4 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M54 Metallopep PF12044.6 008608.4_32928001_2 - 0.048 12.2 0.0 0.078 11.4 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family DUF4953 PF16313.3 008608.4_32928001_2 - 0.048 12.7 0.1 0.074 12.1 0.1 1.2 1 0 0 1 1 1 0 Met-zincin Reprolysin_3 PF13582.4 008608.4_32928001_2 - 0.091 13.1 0.1 0.17 12.3 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.7 008608.4_32928001_2 - 0.3 9.9 0.8 0.44 9.3 0.0 1.6 2 0 0 2 2 2 0 Peptidase M66 Eapp_C PF10238.7 008608.4_32928001_2 - 1.1 9.2 3.9 1.9 8.4 3.9 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein SKG6 PF08693.8 008608.4_32928001_2 - 1.3 8.3 5.6 3.2 7.1 5.6 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DDRGK PF09756.7 008608.4_32928001_2 - 3.2 7.2 18.3 5.1 6.5 18.3 1.2 1 0 0 1 1 1 0 DDRGK domain DUF4366 PF14283.4 008608.4_32928001_2 - 4.3 6.6 5.0 22 4.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) OATP PF03137.18 008608.4_32928001_2 - 4.4 5.4 4.9 6.4 4.8 4.9 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Connexin PF00029.17 008608.4_32928001_2 - 8.2 6.0 6.4 14 5.3 6.4 1.2 1 0 0 1 1 1 0 Connexin Rrn6 PF10214.7 008608.4_32928001_3 - 0.18 10.0 11.4 0.22 9.8 10.2 1.6 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor Sod_Cu PF00080.18 011434.1_32922001_3 - 7.1e-49 165.5 7.3 8.8e-49 165.1 7.3 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) PIN_6 PF17146.2 001258197.1_29624001_2 - 1.7e-33 114.8 0.1 3e-33 114.0 0.1 1.4 1 0 0 1 1 1 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.9 001258197.1_29624001_2 - 6.5e-32 109.4 0.2 1.1e-31 108.6 0.2 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like WRNPLPNID PF15017.4 001258197.1_29624001_2 - 2.4e-19 69.8 6.3 5.2e-19 68.7 6.3 1.6 1 0 0 1 1 1 1 Putative WW-binding domain and destruction box TUSC2 PF15000.4 001109297.1_45725001_3 - 2.6e-41 140.3 0.0 3.5e-41 139.9 0.0 1.2 1 0 0 1 1 1 1 Tumour suppressor candidate 2 TUSC2 PF15000.4 001261666.1_29624001_3 - 4.7e-41 139.5 0.0 6.9e-41 138.9 0.0 1.3 1 0 0 1 1 1 1 Tumour suppressor candidate 2 LRR_8 PF13855.4 001316773.1_09925001_1 - 1.1e-55 185.1 42.1 4.9e-17 61.3 1.9 6.3 1 1 5 6 6 6 6 Leucine rich repeat 7tm_1 PF00001.19 001316773.1_09925001_1 - 3.7e-24 85.3 14.9 3.7e-24 85.3 14.9 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) LRR_5 PF13306.4 001316773.1_09925001_1 - 1.9e-20 73.0 3.3 3.3e-10 39.9 5.8 2.4 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001316773.1_09925001_1 - 7.9e-14 51.4 32.5 1.1e-05 25.5 0.4 5.7 3 2 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001316773.1_09925001_1 - 2.2e-09 36.9 15.7 0.00021 20.7 1.4 3.4 1 1 3 4 4 4 4 Leucine-rich repeat Ldl_recept_a PF00057.16 001316773.1_09925001_1 - 4.2e-07 30.0 5.2 4.2e-07 30.0 5.2 1.9 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A LRRNT PF01462.16 001316773.1_09925001_1 - 0.34 10.5 3.0 0.22 11.1 0.5 2.1 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 001316773.1_09925001_1 - 1.1 9.8 34.3 31 5.5 0.3 9.8 9 1 1 10 10 10 0 Leucine Rich Repeat LRR_8 PF13855.4 001329078.1_37925001_1 - 4.2e-69 228.1 52.2 7.3e-18 64.0 1.7 5.5 1 1 6 7 7 7 6 Leucine rich repeat 7tm_1 PF00001.19 001329078.1_37925001_1 - 1.6e-22 79.9 16.2 2.6e-22 79.2 16.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_4 PF12799.5 001329078.1_37925001_1 - 6.9e-19 67.4 27.9 6e-07 29.5 1.0 6.6 1 1 5 7 7 7 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001329078.1_37925001_1 - 7.8e-19 67.8 0.0 1.1e-09 38.2 0.0 2.5 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001329078.1_37925001_1 - 2.2e-11 43.4 12.5 4.5e-05 22.9 3.2 3.4 1 1 2 3 3 3 3 Leucine-rich repeat Ldl_recept_a PF00057.16 001329078.1_37925001_1 - 3.9e-06 26.9 5.3 3.9e-06 26.9 5.3 2.2 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A LRR_1 PF00560.31 001329078.1_37925001_1 - 0.00032 20.6 26.6 1.5 9.5 0.2 9.0 8 1 1 9 9 9 2 Leucine Rich Repeat LRRNT PF01462.16 001329078.1_37925001_1 - 0.0041 16.6 0.7 0.01 15.4 0.7 1.7 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.4 001329078.1_37925001_1 - 1.8 8.7 16.8 19 5.5 0.1 6.1 6 0 0 6 6 6 0 Leucine Rich repeat LRR_8 PF13855.4 001133200.1_43528001_1 - 1.1e-44 149.8 33.5 4.1e-15 55.2 0.8 5.2 2 2 3 5 5 5 5 Leucine rich repeat 7tm_1 PF00001.19 001133200.1_43528001_1 - 5.5e-23 81.4 16.8 5.5e-23 81.4 16.8 2.2 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) LRR_4 PF12799.5 001133200.1_43528001_1 - 4.2e-17 61.8 32.9 1.1e-07 31.9 0.6 6.0 2 2 4 7 7 7 6 Leucine Rich repeats (2 copies) Ldl_recept_a PF00057.16 001133200.1_43528001_1 - 5.6e-07 29.5 3.9 1.6e-06 28.1 3.9 1.9 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A LRR_9 PF14580.4 001133200.1_43528001_1 - 0.00013 21.3 19.3 0.00051 19.5 4.6 4.1 2 1 3 5 5 5 4 Leucine-rich repeat LRRNT PF01462.16 001133200.1_43528001_1 - 0.00019 20.9 1.2 0.00063 19.2 1.2 2.0 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 001133200.1_43528001_1 - 0.0014 18.7 22.0 34 5.3 0.3 8.7 7 2 1 8 8 8 0 Leucine Rich Repeat LRR_6 PF13516.4 001133200.1_43528001_1 - 5.3 7.2 16.8 13 6.0 0.4 6.4 7 0 0 7 7 7 0 Leucine Rich repeat DUF3807 PF12720.5 001133200.1_43528001_3 - 0.042 14.0 8.2 0.057 13.6 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) bZIP_2 PF07716.13 001199889.1_49823001_1 - 3.1e-18 65.4 12.3 4.5e-18 64.9 12.3 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.19 001199889.1_49823001_1 - 4.8e-05 23.2 11.1 7.5e-05 22.6 11.1 1.3 1 0 0 1 1 1 1 bZIP transcription factor CCD48 PF15799.3 001199889.1_49823001_1 - 0.001 17.5 1.5 0.0013 17.1 1.5 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 48 DUF3450 PF11932.6 001199889.1_49823001_1 - 0.03 13.5 1.3 0.039 13.1 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DivIC PF04977.13 001199889.1_49823001_1 - 0.4 10.3 2.6 0.75 9.5 2.6 1.4 1 0 0 1 1 1 0 Septum formation initiator IncA PF04156.12 001199889.1_49823001_1 - 0.41 10.3 2.8 0.58 9.8 2.8 1.2 1 0 0 1 1 1 0 IncA protein bZIP_Maf PF03131.15 001199889.1_49823001_1 - 0.41 11.1 7.6 0.62 10.5 7.6 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor Uds1 PF15456.4 001199889.1_49823001_1 - 0.49 10.4 6.8 0.77 9.8 6.8 1.2 1 0 0 1 1 1 0 Up-regulated During Septation I_LWEQ PF01608.15 001199889.1_49823001_1 - 0.5 10.5 5.7 0.76 9.9 5.7 1.1 1 0 0 1 1 1 0 I/LWEQ domain Nup54 PF13874.4 001199889.1_49823001_1 - 0.91 9.5 5.9 1.3 8.9 5.9 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 7tm_1 PF00001.19 001005844.1_49823001_1 - 3.7e-41 141.0 12.9 5.3e-41 140.5 12.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) bZIP_2 PF07716.13 001308574.1_39523001_3 - 5.9e-16 58.2 15.2 5.9e-16 58.2 15.2 1.8 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.19 001308574.1_39523001_3 - 2.5e-05 24.1 7.1 4.1e-05 23.4 7.1 1.3 1 0 0 1 1 1 1 bZIP transcription factor Taxilin PF09728.7 001308574.1_39523001_3 - 0.0077 15.4 2.3 0.011 15.0 2.3 1.2 1 0 0 1 1 1 1 Myosin-like coiled-coil protein TolA_bind_tri PF16331.3 001308574.1_39523001_3 - 0.017 15.1 1.5 0.031 14.2 1.5 1.4 1 0 0 1 1 1 0 TolA binding protein trimerisation Lipoprotein_20 PF13942.4 001308574.1_39523001_3 - 0.017 15.0 3.7 0.026 14.3 3.7 1.2 1 0 0 1 1 1 0 YfhG lipoprotein bZIP_Maf PF03131.15 001308574.1_39523001_3 - 0.017 15.5 6.7 0.028 14.8 6.7 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor DivIC PF04977.13 001308574.1_39523001_3 - 0.11 12.2 1.7 0.2 11.3 1.7 1.4 1 0 0 1 1 1 0 Septum formation initiator CENP-Q PF13094.4 001308574.1_39523001_3 - 0.13 12.3 3.1 0.22 11.6 3.1 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Nup54 PF13874.4 001308574.1_39523001_3 - 0.13 12.2 4.2 0.22 11.5 4.2 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Hema_stalk PF08720.8 001308574.1_39523001_3 - 0.16 11.5 0.1 0.24 11.0 0.1 1.1 1 0 0 1 1 1 0 Influenza C hemagglutinin stalk DUF2514 PF10721.7 001308574.1_39523001_3 - 0.49 10.3 5.8 1 9.3 2.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) Cnn_1N PF07989.9 001308574.1_39523001_3 - 0.61 10.1 4.4 1 9.4 4.4 1.3 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 IBB PF01749.18 001308574.1_39523001_3 - 0.84 9.9 9.4 1.4 9.2 9.4 1.3 1 0 0 1 1 1 0 Importin beta binding domain CARD_2 PF16739.3 037921.1_26229120_2 - 1.3e-17 63.4 0.0 2.3e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 Caspase recruitment domain Meis_PKNOX_N PF16493.3 027493.1_32929120_1 - 2.8e-36 123.6 0.1 5.2e-36 122.7 0.1 1.5 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.9 027493.1_32929120_1 - 2.2e-19 69.0 1.2 4.7e-19 67.9 1.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 027493.1_32929120_1 - 2.2e-07 30.5 0.2 4.2e-07 29.6 0.2 1.5 1 0 0 1 1 1 1 Homeobox domain RCC1_2 PF13540.4 130134.1_26223120_3 - 0.038 13.7 0.9 0.038 13.7 0.9 2.0 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat Bcl-2 PF00452.17 027882.1_26222120_1 - 2.8e-13 50.2 0.0 5.3e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family Bcl-2 PF00452.17 027882.1_26222120_3 - 6.8e-07 29.7 0.2 1.1e-06 29.0 0.2 1.3 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family DUF4604 PF15377.4 027882.1_26222120_3 - 6.2 7.1 20.0 9 6.6 20.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) HLH PF00010.24 152880.1_32927120_1 - 7.6e-13 48.1 0.1 2e-12 46.7 0.1 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Atg14 PF10186.7 152880.1_32927120_1 - 0.0074 15.3 1.7 0.013 14.5 1.7 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 TolA_bind_tri PF16331.3 152880.1_32927120_1 - 0.13 12.2 6.3 0.24 11.4 6.3 1.3 1 0 0 1 1 1 0 TolA binding protein trimerisation DUF3584 PF12128.6 152880.1_32927120_1 - 0.17 9.2 2.2 0.22 8.9 2.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) bZIP_1 PF00170.19 152880.1_32927120_1 - 0.72 9.9 2.6 1.2 9.1 2.6 1.3 1 0 0 1 1 1 0 bZIP transcription factor DivIC PF04977.13 152880.1_32927120_1 - 1.2 8.8 4.6 2.1 8.0 4.6 1.3 1 0 0 1 1 1 0 Septum formation initiator I-set PF07679.14 026665.1_26223120_2 - 0.02 14.8 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ig_3 PF13927.4 026665.1_26223120_2 - 0.05 14.1 0.5 0.12 12.9 0.0 1.8 2 0 0 2 2 2 0 Immunoglobulin domain XPA_C PF05181.10 149094.1_26224120_3 - 1.9e-27 94.8 1.7 3.2e-27 94.1 1.7 1.4 1 0 0 1 1 1 1 XPA protein C-terminus MscS_TM PF12794.5 149094.1_26224120_3 - 1.9 7.1 6.3 2.1 7.0 0.5 2.1 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 SNF PF00209.16 121629.1_32929120_1 - 1e-222 740.3 31.7 1.3e-222 740.0 31.7 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Cys_knot PF00007.20 001082491.1_21021001_3 - 1.8e-34 118.0 13.8 2.3e-34 117.7 13.8 1.1 1 0 0 1 1 1 1 Cystine-knot domain Fibrinogen_C PF00147.16 001038644.1_49824001_2 - 1.3e-53 182.0 0.0 1.8e-53 181.5 0.0 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain SlyX PF04102.10 001038644.1_49824001_2 - 4.5e-05 23.9 3.9 0.00054 20.4 3.6 2.4 2 0 0 2 2 2 1 SlyX IncA PF04156.12 001038644.1_49824001_2 - 0.0046 16.6 0.5 0.0085 15.8 0.5 1.4 1 0 0 1 1 1 1 IncA protein Spc7 PF08317.9 001038644.1_49824001_2 - 0.064 12.0 1.6 0.097 11.4 1.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein HrpB7 PF09486.8 001038644.1_49824001_2 - 0.14 12.4 1.9 0.3 11.3 0.4 1.9 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Fib_alpha PF08702.8 001038644.1_49824001_2 - 0.16 12.0 2.6 0.76 9.8 3.0 1.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DivIC PF04977.13 001038644.1_49824001_2 - 0.18 11.5 4.4 0.34 10.6 4.4 1.4 1 0 0 1 1 1 0 Septum formation initiator ADIP PF11559.6 001038644.1_49824001_2 - 0.24 11.4 5.6 0.43 10.5 5.6 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Phage_attach PF05354.9 001038644.1_49824001_3 - 0.14 11.9 0.3 0.31 10.8 0.3 1.4 1 0 0 1 1 1 0 Phage Head-Tail Attachment DUF563 PF04577.12 001009171.1_39724001_1 - 8.4e-28 97.8 0.7 1.2e-27 97.2 0.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Kazal_1 PF00050.19 213864.1_49821001_2 - 6.2e-19 67.6 4.2 8.2e-19 67.2 4.2 1.2 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 213864.1_49821001_2 - 2.4e-13 49.9 0.9 3.5e-13 49.4 0.9 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain LRR_8 PF13855.4 001282075.1_39726001_2 - 2.8e-06 26.9 1.5 2.8e-06 26.9 1.5 2.0 2 0 0 2 2 2 1 Leucine rich repeat LRR_9 PF14580.4 001282075.1_39726001_2 - 0.00059 19.2 0.1 0.0014 18.0 0.0 1.5 1 1 1 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.5 001282075.1_39726001_2 - 0.0073 16.5 0.3 0.0073 16.5 0.3 3.5 2 1 2 4 4 4 2 Leucine Rich repeats (2 copies) Methyltransf_3 PF01596.15 001282075.1_39726001_3 - 2.8e-13 49.4 0.0 4.2e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.4 001282075.1_39726001_3 - 1.6e-09 38.6 0.0 2.5e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.17 001282075.1_39726001_3 - 0.0061 16.2 0.0 0.0098 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.4 001282075.1_39726001_3 - 0.088 12.5 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Serum_albumin PF00273.18 001081952.1_21025001_3 - 2e-146 483.5 33.0 4e-50 169.9 3.7 3.0 3 0 0 3 3 3 3 Serum albumin family DUF4144 PF13642.4 001081952.1_21025001_3 - 0.008 16.6 4.4 7.1 7.1 0.3 3.8 3 0 0 3 3 3 2 protein structure with unknown function VitD-bind_III PF09164.8 001081952.1_21025001_3 - 0.041 13.8 18.9 0.083 12.8 0.1 5.0 6 0 0 6 6 6 0 Vitamin D binding protein, domain III tRNA-synt_1f PF01921.16 001081952.1_21025001_3 - 0.13 11.0 0.2 0.27 10.0 0.2 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (K) Tyrosinase PF00264.18 001082077.1_37924001_1 - 3.2e-43 148.4 0.8 4.5e-43 148.0 0.8 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase Laminin_EGF PF00053.22 001082077.1_37924001_1 - 0.0052 16.8 2.8 0.0052 16.8 2.8 2.9 3 0 0 3 3 3 2 Laminin EGF domain DUF1191 PF06697.10 001082077.1_37924001_1 - 0.16 11.1 0.0 0.28 10.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) Radical_SAM PF04055.19 001082077.1_37924001_3 - 0.12 12.7 0.1 0.18 12.0 0.1 1.1 1 0 0 1 1 1 0 Radical SAM superfamily Zona_pellucida PF00100.21 213893.1_49823001_1 - 1.2e-45 156.2 0.0 1.4e-45 155.9 0.0 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain IGFBP PF00219.16 030868.2_45723001_1 - 2.5e-11 43.9 21.7 2.5e-11 43.9 21.7 5.6 4 3 1 5 5 5 1 Insulin-like growth factor binding protein Cys_knot PF00007.20 030868.2_45723001_1 - 1.9e-10 40.8 11.0 1.9e-10 40.8 11.0 3.4 4 0 0 4 4 4 1 Cystine-knot domain VWC PF00093.16 030868.2_45723001_1 - 5.9e-10 39.2 11.4 5.9e-10 39.2 11.4 5.6 4 1 0 5 5 5 1 von Willebrand factor type C domain DUF2170 PF09938.7 001081933.1_21022001_1 - 0.014 14.9 0.0 0.021 14.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2170) fn2 PF00040.17 001081933.1_21022001_3 - 2.2e-28 98.1 25.9 9.7e-17 60.8 6.2 2.4 2 0 0 2 2 2 2 Fibronectin type II domain Sperm_Ag_HE2 PF05324.11 001110237.1_39721001_2 - 1.2e-35 121.5 2.2 1.6e-35 121.2 2.2 1.1 1 0 0 1 1 1 1 Sperm antigen HE2 Defensin_beta PF00711.17 001110237.1_39721001_2 - 0.0031 17.4 3.5 0.0047 16.8 3.5 1.3 1 0 0 1 1 1 1 Beta defensin Ric8 PF10165.7 001132662.1_43526001_3 - 9.1e-125 417.1 0.2 1.7e-124 416.2 0.1 1.5 2 0 0 2 2 2 1 Guanine nucleotide exchange factor synembryn PUL PF08324.9 001132662.1_43526001_3 - 0.036 13.2 0.1 0.036 13.2 0.1 1.7 2 0 0 2 2 2 0 PUL domain Arm PF00514.21 001132662.1_43526001_3 - 0.039 13.9 0.1 1.6 8.7 0.0 3.0 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Sperm_Ag_HE2 PF05324.11 001110238.1_39722001_2 - 3.6e-34 116.8 1.3 5.7e-34 116.2 1.3 1.3 1 0 0 1 1 1 1 Sperm antigen HE2 Defensin_beta PF00711.17 001110238.1_39722001_2 - 3.8e-09 36.3 9.4 3.8e-09 36.3 9.4 1.5 2 0 0 2 2 2 1 Beta defensin Defensin_beta_2 PF13841.4 001110238.1_39722001_2 - 0.0012 19.2 8.8 0.0021 18.4 8.8 1.4 1 0 0 1 1 1 1 Beta defensin Peptidase_M2 PF01401.16 001082395.1_37929001_3 - 0 1712.1 4.1 5.3e-259 860.5 0.5 2.0 2 0 0 2 2 2 2 Angiotensin-converting enzyme Imm-NTF2-2 PF15631.4 001082395.1_37929001_3 - 0.051 13.7 0.1 2.6 8.2 0.0 2.4 2 0 0 2 2 2 0 NTF2 fold immunity protein MHC_II_beta PF00969.17 001113694.1_49823001_1 - 1.6e-36 124.2 0.2 2.5e-36 123.5 0.2 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001113694.1_49823001_1 - 1e-26 93.1 0.1 2.1e-26 92.1 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001113694.1_49823001_1 - 7.4e-06 26.4 0.0 1.4e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 001113694.1_49823001_1 - 0.0039 17.1 0.1 0.007 16.3 0.1 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001113694.1_49823001_1 - 0.0097 15.9 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001113694.1_49823001_1 - 0.011 16.0 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain MHC_I PF00129.16 001113694.1_49823001_1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 Marek_A PF02124.13 001113694.1_49823001_1 - 0.067 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Marek's disease glycoprotein A A2M_comp PF07678.12 001173052.1_09929001_1 - 2.4e-94 315.3 1.9 3.9e-94 314.6 1.9 1.4 1 0 0 1 1 1 1 A-macroglobulin complement component A2M_N_2 PF07703.12 001173052.1_09929001_1 - 1.1e-33 116.3 2.0 2.2e-29 102.4 0.0 3.6 3 0 0 3 3 3 2 Alpha-2-macroglobulin family N-terminal region A2M PF00207.20 001173052.1_09929001_1 - 7.3e-31 105.7 0.4 3.4e-30 103.6 0.0 2.5 3 0 0 3 3 3 1 Alpha-2-macroglobulin family A2M_recep PF07677.12 001173052.1_09929001_1 - 6.3e-27 94.0 0.7 2.3e-26 92.2 0.7 2.1 1 0 0 1 1 1 1 A-macroglobulin receptor A2M_N PF01835.17 001173052.1_09929001_1 - 1.6e-22 79.6 0.0 2.9e-21 75.6 0.0 3.2 3 0 0 3 3 3 1 MG2 domain Thiol-ester_cl PF10569.7 001173052.1_09929001_1 - 2.7e-17 62.0 2.9 6.8e-17 60.7 2.9 1.8 1 0 0 1 1 1 1 Alpha-macro-globulin thiol-ester bond-forming region SVA PF05326.9 001173052.1_09929001_1 - 9.2e-06 25.5 0.1 0.00033 20.5 0.0 3.5 4 0 0 4 4 4 1 Seminal vesicle autoantigen (SVA) Big_1 PF02369.14 001173052.1_09929001_1 - 1.1 9.2 5.5 2.3 8.2 0.8 3.3 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 1) CarboxypepD_reg PF13620.4 001173052.1_09929001_1 - 3.3 7.9 6.9 2.1 8.6 0.0 3.9 5 0 0 5 5 5 0 Carboxypeptidase regulatory-like domain ANF_receptor PF01094.26 001132517.1_43529001_1 - 5e-71 239.5 0.0 6.5e-71 239.1 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 001132517.1_43529001_1 - 2.5e-52 177.9 4.1 5e-52 176.9 4.1 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Peripla_BP_6 PF13458.4 001132517.1_43529001_1 - 1.3e-19 71.0 0.0 2e-19 70.4 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein Kei1 PF08552.9 001132517.1_43529001_1 - 0.024 14.2 1.0 0.96 9.0 0.1 2.5 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 DUF3995 PF13160.4 001132517.1_43529001_1 - 0.042 14.1 0.0 0.042 14.1 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3995) PKcGMP_CC PF16808.3 001132517.1_43529001_1 - 0.14 11.9 6.5 0.33 10.7 6.5 1.6 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase RRM_1 PF00076.20 001131794.1_43527001_2 - 5.7e-34 115.6 0.2 7e-16 57.7 0.3 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001131794.1_43527001_2 - 8.7e-10 38.5 0.2 4.8e-05 23.3 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 001131794.1_43527001_2 - 0.0009 19.0 0.2 0.23 11.3 0.1 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif COesterase PF00135.26 001310559.1_31324001_3 - 5.8e-159 530.2 0.0 6.7e-159 530.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001310559.1_31324001_3 - 1.9e-09 37.5 0.6 8.3e-09 35.5 0.6 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 001310559.1_31324001_3 - 7.6e-05 22.1 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Trypsin PF00089.24 001123006.1_39522001_3 - 2.2e-69 233.5 0.0 2.5e-69 233.3 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001123006.1_39522001_3 - 1.6e-07 32.2 0.1 3.4e-07 31.1 0.1 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001123006.1_39522001_3 - 3.1e-06 27.4 0.1 2.2e-05 24.7 0.1 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Guanylate_cyc PF00211.18 214105.1_49828001_2 - 3.8e-67 225.3 0.0 5.9e-67 224.7 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.15 214105.1_49828001_2 - 1.6e-34 119.2 0.1 3.3e-34 118.2 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 214105.1_49828001_2 - 1.7e-27 96.3 0.2 3.1e-27 95.4 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain ANF_receptor PF01094.26 214105.1_49828001_2 - 3.4e-08 32.8 0.0 5.8e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Ldl_recept_b PF00058.15 214020.2_49829001_2 - 1.2e-44 150.4 3.7 3e-09 37.1 0.0 9.1 10 0 0 10 10 10 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 214020.2_49829001_2 - 1.2e-30 105.3 128.3 4.5e-08 33.1 5.8 10.3 9 1 1 10 10 10 6 Coagulation Factor Xa inhibitory site cEGF PF12662.5 214020.2_49829001_2 - 1.3e-21 76.0 61.6 1.1e-07 31.5 1.1 9.2 9 0 0 9 9 9 6 Complement Clr-like EGF-like EGF_CA PF07645.13 214020.2_49829001_2 - 2.4e-18 65.9 36.2 2.9e-09 36.8 7.3 9.2 9 0 0 9 9 9 3 Calcium-binding EGF domain EGF PF00008.25 214020.2_49829001_2 - 2.3e-14 53.2 110.6 0.0023 18.0 3.4 10.0 9 0 0 9 9 9 8 EGF-like domain DUF5050 PF16472.3 214020.2_49829001_2 - 9.3e-12 44.6 0.0 1.3e-06 27.7 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF5050) EGF_3 PF12947.5 214020.2_49829001_2 - 2.9e-09 36.8 110.5 5.9e-05 23.0 10.4 9.2 9 0 0 9 9 9 4 EGF domain Plasmod_Pvs28 PF06247.9 214020.2_49829001_2 - 6.7e-05 23.0 1.0 6.7e-05 23.0 1.0 8.5 8 1 1 9 9 9 3 Pvs28 EGF domain Tr-sialidase_C PF11052.6 214020.2_49829001_2 - 0.047 13.8 6.9 0.15 12.1 6.9 1.9 1 0 0 1 1 1 0 Trans-sialidase of Trypanosoma hydrophobic C-terminal SUZ-C PF12901.5 214020.2_49829001_2 - 0.061 13.3 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 SUZ-C motif EPO_TPO PF00758.16 001081825.2_21023001_1 - 1.1e-69 233.4 0.0 1.5e-69 233.0 0.0 1.2 1 0 0 1 1 1 1 Erythropoietin/thrombopoietin 2TM PF13239.4 001081825.2_21023001_2 - 0.092 12.9 0.2 0.15 12.2 0.2 1.3 1 0 0 1 1 1 0 2TM domain Hormone_1 PF00103.18 001082675.1_37922001_3 - 5e-81 271.4 0.4 6e-81 271.2 0.4 1.0 1 0 0 1 1 1 1 Somatotropin hormone family KIAA1430 PF13879.4 001082675.1_37922001_3 - 0.05 14.2 0.7 1.1 10.0 0.1 2.3 2 0 0 2 2 2 0 KIAA1430 homologue IFN-gamma PF00714.15 001281631.1_31322001_2 - 9.9e-63 210.0 2.7 1.3e-62 209.6 2.7 1.1 1 0 0 1 1 1 1 Interferon gamma WD40 PF00400.30 001132899.1_43526001_2 - 1.3e-42 142.8 34.1 1.1e-05 25.9 0.1 11.1 11 0 0 11 11 11 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001132899.1_43526001_2 - 8e-21 74.0 0.3 0.0017 18.5 0.0 7.6 3 3 5 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001132899.1_43526001_2 - 2.8e-10 40.3 0.1 0.055 13.2 0.0 4.6 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 001132899.1_43526001_2 - 6.3e-06 25.3 4.3 0.05 12.4 0.0 5.0 3 2 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.10 001132899.1_43526001_2 - 0.0016 18.2 0.4 8.3 6.4 0.0 4.3 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat PQQ PF01011.19 001132899.1_43526001_2 - 0.0058 16.4 1.2 0.019 14.7 0.1 2.6 2 0 0 2 2 2 1 PQQ enzyme repeat BBS2_Mid PF14783.4 001132899.1_43526001_2 - 0.017 15.0 0.0 0.54 10.2 0.0 3.4 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.3 001132899.1_43526001_2 - 0.021 14.0 0.0 7.3 5.7 0.1 2.9 3 0 0 3 3 3 0 WD40-like domain Nbas_N PF15492.4 001132899.1_43526001_2 - 0.025 13.8 0.4 32 3.6 0.0 4.0 2 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal IKI3 PF04762.10 001132899.1_43526001_2 - 0.026 12.4 0.0 0.37 8.6 0.0 2.4 2 1 0 3 3 3 0 IKI3 family Reprolysin PF01421.17 001172910.1_09926001_3 - 7.1e-64 215.3 0.3 1.8e-63 213.9 0.3 1.8 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 001172910.1_09926001_3 - 3.6e-21 75.6 5.9 3.6e-21 75.6 5.9 4.0 3 2 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 001172910.1_09926001_3 - 3.4e-20 72.6 0.0 6.2e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.21 001172910.1_09926001_3 - 1.6e-19 70.3 36.6 1.6e-19 70.3 36.6 4.0 4 1 0 4 4 4 1 Disintegrin Reprolysin_5 PF13688.4 001172910.1_09926001_3 - 5.8e-05 23.2 0.0 5.8e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12 TNFR_c6 PF00020.16 213969.1_49825001_1 - 4.6e-18 65.2 52.8 1.5e-09 38.0 8.4 4.5 4 0 0 4 4 4 3 TNFR/NGFR cysteine-rich region Death PF00531.20 213969.1_49825001_1 - 2.7e-17 62.6 0.1 4.4e-17 61.9 0.1 1.3 1 0 0 1 1 1 1 Death domain Prion PF00377.16 001009261.1_39526001_2 - 6.5e-51 171.0 0.2 1e-50 170.3 0.2 1.3 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain Doppel PF11466.6 001009261.1_39526001_2 - 7.8e-20 70.1 2.6 7.8e-20 70.1 2.6 1.8 2 0 0 2 2 2 1 Prion-like protein Doppel TGF_beta PF00019.18 001114767.1_39523001_1 - 1e-27 96.9 0.2 2.1e-27 95.9 0.2 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain Zona_pellucida PF00100.21 001082295.2_37924001_2 - 4.3e-53 180.5 0.6 1.9e-52 178.4 0.1 1.9 2 0 0 2 2 2 1 Zona pellucida-like domain Trefoil PF00088.16 001082295.2_37924001_2 - 9.4e-10 38.1 5.5 2.8e-09 36.6 5.5 1.9 1 0 0 1 1 1 1 Trefoil (P-type) domain Lectin_C PF00059.19 001082334.1_37929001_2 - 1.3e-121 398.9 44.0 3e-18 66.4 0.4 8.5 8 0 0 8 8 8 8 Lectin C-type domain fn2 PF00040.17 001082334.1_37929001_2 - 3.5e-17 62.3 8.2 3.5e-17 62.3 8.2 3.1 3 0 0 3 3 3 1 Fibronectin type II domain UL45 PF05473.10 001082334.1_37929001_2 - 8.8e-12 44.9 4.2 0.00063 19.3 0.1 6.3 7 1 1 8 8 8 3 UL45 protein, carbohydrate-binding C-type lectin-like Chordopox_A33R PF05966.10 001082334.1_37929001_2 - 0.0064 15.7 4.9 0.038 13.1 0.1 3.7 4 0 0 4 4 4 1 Chordopoxvirus A33R protein Xlink PF00193.15 001082334.1_37929001_2 - 0.015 15.5 7.7 0.4 10.9 0.1 5.7 6 1 1 7 7 7 0 Extracellular link domain Cystatin PF00031.19 001009802.1_39524001_2 - 2.2e-23 82.2 0.1 3.3e-19 68.8 0.1 2.3 2 0 0 2 2 2 2 Cystatin domain Cathelicidins PF00666.15 001009802.1_39524001_2 - 0.02 15.0 0.4 0.074 13.2 0.1 2.0 2 0 0 2 2 2 0 Cathelicidin TGFb_propeptide PF00688.16 001009428.2_39526001_2 - 2.4e-30 106.0 0.0 3.6e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001009428.2_39526001_2 - 9.3e-28 97.1 0.7 2.1e-27 95.9 0.7 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain Sushi PF00084.18 213942.1_49822001_1 - 8e-24 83.9 4.2 1.2e-12 48.1 0.5 2.6 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) RnaseA PF00074.18 007894.2_32922001_3 - 6.4e-32 110.5 8.6 9.4e-32 110.0 8.6 1.3 1 0 0 1 1 1 1 Pancreatic ribonuclease ANF_receptor PF01094.26 174002.3_06529001_1 - 6.5e-107 357.5 0.0 9.1e-107 357.1 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 174002.3_06529001_1 - 1.9e-64 217.5 30.6 2.7e-64 217.0 29.5 1.8 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 174002.3_06529001_1 - 2.5e-16 59.3 11.1 2.5e-16 59.3 11.1 2.5 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 174002.3_06529001_1 - 1e-10 41.8 0.0 7e-10 39.0 0.0 2.1 1 1 0 1 1 1 1 Periplasmic binding protein Ephrin_rec_like PF07699.11 174002.3_06529001_1 - 0.0064 16.1 7.5 0.019 14.6 7.5 1.7 1 0 0 1 1 1 1 Putative ephrin-receptor like Pex14_N PF04695.11 174002.3_06529001_1 - 2.4 8.7 10.3 5.6 7.5 10.3 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Rieske PF00355.24 017123.1_45723001_2 - 0.017 14.9 1.6 0.03 14.1 1.6 1.3 1 0 0 1 1 1 0 Rieske [2Fe-2S] domain EGF PF00008.25 017123.1_45723001_2 - 0.12 12.6 4.5 0.21 11.8 4.5 1.4 1 0 0 1 1 1 0 EGF-like domain EGF_2 PF07974.11 017123.1_45723001_2 - 1.2 9.5 5.9 2.1 8.7 5.9 1.4 1 0 0 1 1 1 0 EGF-like domain MACPF PF01823.17 001082668.1_37925001_2 - 9.8e-34 117.1 0.0 1.4e-32 113.3 0.0 2.1 2 0 0 2 2 2 1 MAC/Perforin domain Ldl_recept_a PF00057.16 001082668.1_37925001_2 - 3.7e-09 36.5 11.2 1.8e-08 34.3 11.2 2.3 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A TSP_1 PF00090.17 001082668.1_37925001_2 - 5e-07 29.7 24.5 2.7e-06 27.4 11.3 3.7 4 0 0 4 4 4 2 Thrombospondin type 1 domain Reprolysin PF01421.17 020301.1_45728001_2 - 9e-70 234.5 0.1 9e-70 234.5 0.1 2.1 3 0 0 3 3 3 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 020301.1_45728001_2 - 3e-27 95.4 0.2 6.2e-27 94.4 0.2 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_CR PF08516.10 020301.1_45728001_2 - 3.8e-25 88.4 10.0 3.8e-25 88.4 10.0 3.5 3 1 1 4 4 4 1 ADAM cysteine-rich Disintegrin PF00200.21 020301.1_45728001_2 - 5.5e-19 68.6 28.9 5.5e-19 68.6 28.9 3.5 3 0 0 3 3 3 1 Disintegrin Reprolysin_5 PF13688.4 020301.1_45728001_2 - 5.5e-11 42.8 0.0 1e-10 42.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 020301.1_45728001_2 - 1.1e-10 42.0 0.0 2.1e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 020301.1_45728001_2 - 1.8e-05 24.4 0.0 3.8e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 020301.1_45728001_2 - 7.2e-05 22.6 0.0 0.00014 21.7 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.6 020301.1_45728001_2 - 0.0054 16.2 0.0 0.01 15.3 0.0 1.4 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase C2-set PF05790.13 001085434.1_21023001_3 - 2.1e-15 56.5 1.4 2.1e-15 56.5 1.4 1.9 2 0 0 2 2 2 1 Immunoglobulin C2-set domain V-set PF07686.15 001085434.1_21023001_3 - 1.8e-09 37.6 0.2 3.1e-08 33.6 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.4 001085434.1_21023001_3 - 7.7e-05 22.8 1.4 0.0011 19.1 0.4 2.6 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.4 001085434.1_21023001_3 - 0.00046 20.6 1.0 0.3 11.6 0.0 3.1 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001085434.1_21023001_3 - 0.00069 19.5 2.2 0.012 15.6 0.1 2.7 2 1 0 2 2 2 1 Immunoglobulin I-set domain YhzD PF14120.4 001085434.1_21023001_3 - 0.16 11.9 0.1 0.16 11.9 0.1 1.7 2 0 0 2 2 2 0 YhzD-like protein Cys_knot PF00007.20 001172948.2_09923001_1 - 1.5e-32 111.9 15.9 2.8e-32 111.0 15.9 1.4 1 0 0 1 1 1 1 Cystine-knot domain Interferon PF00143.17 001002832.1_49823001_1 - 1.3e-42 145.5 2.3 1.8e-42 145.1 2.3 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain Cpn60_TCP1 PF00118.22 001132213.2_43524001_1 - 1.3e-155 518.7 6.0 1.5e-155 518.5 6.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PRY PF13765.4 001346745.1_32923001_2 - 1.5e-15 56.4 0.0 3.6e-15 55.2 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain zf-RING_UBOX PF13445.4 001346745.1_32923001_2 - 5.3e-12 45.4 7.5 5.3e-12 45.4 7.5 2.2 1 1 1 2 2 2 1 RING-type zinc-finger SPRY PF00622.26 001346745.1_32923001_2 - 6.1e-10 39.1 0.0 1.2e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 001346745.1_32923001_2 - 8.3e-10 38.5 14.2 8.3e-10 38.5 14.2 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.22 001346745.1_32923001_2 - 2.1e-09 37.3 2.7 2.1e-09 37.3 2.7 3.5 2 1 0 2 2 1 1 B-box zinc finger zf-C3HC4 PF00097.23 001346745.1_32923001_2 - 3e-09 36.5 12.4 8.9e-09 34.9 12.4 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001346745.1_32923001_2 - 1.8e-08 34.0 12.7 4e-08 32.8 12.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001346745.1_32923001_2 - 1.8e-07 31.1 12.0 1.8e-07 31.1 12.0 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 001346745.1_32923001_2 - 2e-07 30.6 13.8 2e-07 30.6 13.8 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001346745.1_32923001_2 - 2.3e-07 30.5 11.1 2.3e-07 30.5 11.1 2.3 2 0 0 2 2 2 1 zinc-RING finger domain U-box PF04564.13 001346745.1_32923001_2 - 0.00096 19.1 0.0 0.0022 18.0 0.0 1.5 1 0 0 1 1 1 1 U-box domain Prok-RING_4 PF14447.4 001346745.1_32923001_2 - 0.0011 18.6 13.7 0.0042 16.8 13.7 2.0 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Baculo_IE-1 PF05290.9 001346745.1_32923001_2 - 0.0082 16.0 4.0 0.018 14.8 4.0 1.5 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-Nse PF11789.6 001346745.1_32923001_2 - 0.017 14.8 6.1 0.037 13.7 6.1 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Serendipity_A PF05482.10 001346745.1_32923001_2 - 0.047 12.2 0.5 0.062 11.8 0.5 1.1 1 0 0 1 1 1 0 Serendipity locus alpha protein (SRY-A) zf-RING_4 PF14570.4 001346745.1_32923001_2 - 0.12 12.0 11.4 0.29 10.8 9.5 2.6 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain DUF2959 PF11172.6 001346745.1_32923001_2 - 0.12 12.3 0.4 0.77 9.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2959) zf-ANAPC11 PF12861.5 001346745.1_32923001_2 - 0.3 11.0 6.0 0.98 9.4 6.0 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger ZapB PF06005.10 001346745.1_32923001_2 - 0.35 11.2 2.3 2.2 8.6 0.1 2.3 2 0 0 2 2 2 0 Cell division protein ZapB CagY_M PF07337.9 001346745.1_32923001_2 - 4.5 6.8 6.8 15 5.2 0.6 2.5 2 0 0 2 2 2 0 DC-EC Repeat WAP PF00095.19 173109.1_45722001_1 - 7.2e-19 67.8 39.9 4.1e-10 39.7 16.7 2.4 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' LRR_8 PF13855.4 001199353.1_39727001_2 - 2.9e-06 26.8 1.5 2.9e-06 26.8 1.5 2.0 2 0 0 2 2 2 1 Leucine rich repeat LRR_9 PF14580.4 001199353.1_39727001_2 - 0.00063 19.1 0.1 0.0015 18.0 0.0 1.5 1 1 1 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.5 001199353.1_39727001_2 - 0.0076 16.5 0.3 0.0076 16.5 0.3 3.5 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) Methyltransf_3 PF01596.15 001199353.1_39727001_3 - 3e-13 49.3 0.0 4.4e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.4 001199353.1_39727001_3 - 1.7e-09 38.5 0.0 2.6e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.17 001199353.1_39727001_3 - 0.0064 16.1 0.0 0.01 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.4 001199353.1_39727001_3 - 0.093 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DUF4689 PF15755.3 001105161.1_21023001_1 - 1.4e-05 24.7 0.9 1.4e-05 24.7 0.9 3.2 1 1 2 3 3 3 1 Domain of unknown function (DUF4689) EVI2A PF05399.9 001105161.1_21023001_1 - 0.022 14.2 8.9 0.059 12.8 8.1 2.0 1 1 1 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) Drf_DAD PF06345.9 001105161.1_21023001_1 - 0.062 13.2 1.2 5.2 7.2 0.0 3.7 3 0 0 3 3 3 0 DRF Autoregulatory Domain SRCR PF00530.16 001082033.1_37929001_1 - 1.6e-255 827.5 106.5 7.4e-33 112.9 7.5 8.5 8 0 0 8 8 8 8 Scavenger receptor cysteine-rich domain CUB PF00431.18 001082033.1_37929001_1 - 3.2e-57 191.5 0.3 3e-28 98.2 0.0 2.5 2 0 0 2 2 2 2 CUB domain Zona_pellucida PF00100.21 001082033.1_37929001_1 - 9.1e-46 156.5 9.1 9.1e-46 156.5 9.1 2.1 2 0 0 2 2 2 1 Zona pellucida-like domain SRCR_2 PF15494.4 001082033.1_37929001_1 - 3.2e-30 104.4 54.0 0.0012 19.2 1.0 9.1 9 0 0 9 9 9 8 Scavenger receptor cysteine-rich domain CUB_2 PF02408.18 001082033.1_37929001_1 - 9.2e-06 25.3 2.8 0.11 12.2 0.0 3.1 3 0 0 3 3 3 2 CUB-like domain Zea_mays_MuDR PF05928.9 001082033.1_37929001_1 - 0.27 10.7 2.8 1.2e+02 2.1 0.0 5.2 6 0 0 6 6 6 0 Zea mays MURB-like protein (MuDR) DUF2227 PF09988.7 001082033.1_37929001_1 - 2.9 7.6 34.1 24 4.6 0.5 7.1 7 0 0 7 7 7 0 Uncharacterized metal-binding protein (DUF2227) IL6 PF00489.15 001009392.1_39523001_2 - 6.2e-86 286.6 2.6 7.4e-86 286.3 2.6 1.1 1 0 0 1 1 1 1 Interleukin-6/G-CSF/MGF family IL23 PF16649.3 001009392.1_39523001_2 - 0.00035 20.5 0.1 0.00055 19.9 0.1 1.2 1 0 0 1 1 1 1 Interleukin 23 subunit alpha GCSF PF16647.3 001009392.1_39523001_2 - 0.013 15.2 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Granulocyte colony-stimulating factor Sec16 PF12932.5 001009392.1_39523001_2 - 0.069 13.6 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 Vesicle coat trafficking protein Sec16 mid-region 7tm_2 PF00002.22 172091.2_45724001_3 - 1.9e-80 269.6 17.6 2.7e-80 269.1 17.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 172091.2_45724001_3 - 1.2e-15 57.4 6.4 3.3e-15 56.0 6.4 1.8 1 0 0 1 1 1 1 Hormone receptor domain Dicty_CAR PF05462.9 172091.2_45724001_3 - 0.31 10.0 16.3 0.58 9.1 16.3 1.4 1 1 0 1 1 1 0 Slime mold cyclic AMP receptor MHC_II_beta PF00969.17 001032991.1_32324001_1 - 1.2e-29 102.2 0.3 2.2e-29 101.3 0.3 1.5 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001032991.1_32324001_1 - 1.2e-25 89.7 0.0 1.9e-25 89.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001032991.1_32324001_1 - 1.5e-05 25.4 0.0 2.6e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001032991.1_32324001_1 - 0.00029 20.8 0.0 0.00051 20.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001032991.1_32324001_1 - 0.0026 17.9 0.0 0.0046 17.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001032991.1_32324001_1 - 0.027 14.4 0.0 0.046 13.7 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin I-set domain TGF_beta PF00019.18 019216.2_45722001_1 - 2.7e-21 76.3 1.3 3.8e-21 75.8 1.3 1.2 1 0 0 1 1 1 1 Transforming growth factor beta like domain BcsB PF03170.11 019216.2_45722001_1 - 0.027 12.8 0.0 0.036 12.4 0.0 1.1 1 0 0 1 1 1 0 Bacterial cellulose synthase subunit Asp PF00026.21 001009299.1_39523001_3 - 5.4e-110 367.6 0.0 6.3e-110 367.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001009299.1_39523001_3 - 1.8e-10 41.2 0.2 1.7e-08 34.8 0.2 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.4 001009299.1_39523001_3 - 1.6e-06 27.8 0.0 5.6e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal A1_Propeptide PF07966.10 001009299.1_39523001_3 - 2.4e-05 24.0 0.0 4.3e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 A1 Propeptide V-set_2 PF15910.3 001009844.1_22424001_2 - 1.1e-11 44.7 2.0 2.4e-11 43.6 1.6 1.7 1 1 1 2 2 2 1 ICOS V-set domain V-set PF07686.15 001009844.1_22424001_2 - 5.5e-05 23.1 0.2 8.5e-05 22.5 0.2 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain MHC_II_beta PF00969.17 001123402.1_39522001_1 - 2.4e-34 117.1 0.3 3.9e-34 116.5 0.3 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001123402.1_39522001_1 - 2e-24 85.7 0.2 5.8e-24 84.2 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001123402.1_39522001_1 - 0.00052 20.5 0.1 0.0016 18.9 0.0 1.9 1 1 1 2 2 2 1 Immunoglobulin domain DUF202 PF02656.13 001123402.1_39522001_1 - 0.038 14.3 0.0 0.074 13.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) ig PF00047.23 001123402.1_39522001_1 - 0.057 13.5 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Zona_pellucida PF00100.21 001009260.1_22424001_3 - 2.9e-52 177.8 0.1 5.3e-52 176.9 0.0 1.5 2 0 0 2 2 2 1 Zona pellucida-like domain Trefoil PF00088.16 001009260.1_22424001_3 - 1.9e-09 37.1 7.5 5.4e-09 35.6 7.5 1.9 1 0 0 1 1 1 1 Trefoil (P-type) domain Trehalase PF01204.16 001082290.1_37924001_1 - 1.1e-180 601.7 0.2 1.3e-180 601.5 0.2 1.0 1 0 0 1 1 1 1 Trehalase Glyco_hydro_63 PF03200.14 001082290.1_37924001_1 - 9.2e-05 21.2 1.0 0.046 12.3 0.0 2.6 2 1 0 3 3 3 2 Glycosyl hydrolase family 63 C-terminal domain GDE_C PF06202.12 001082290.1_37924001_1 - 0.071 11.9 0.1 0.39 9.5 0.0 1.9 2 0 0 2 2 2 0 Amylo-alpha-1,6-glucosidase Bac_chlorC PF02043.15 001082290.1_37924001_1 - 0.15 11.9 0.0 2.8 7.9 0.0 2.4 2 0 0 2 2 2 0 Bacteriochlorophyll C binding protein IL15 PF02372.13 214390.1_49821001_1 - 3.9e-58 195.1 4.9 3.9e-58 195.1 4.9 1.6 2 0 0 2 2 2 1 Interleukin 15 IL23 PF16649.3 001172969.1_09922001_1 - 7.6e-95 315.1 0.3 8.9e-95 314.9 0.3 1.0 1 0 0 1 1 1 1 Interleukin 23 subunit alpha Peptidase_C13 PF01650.16 001032358.1_49823001_1 - 2.2e-43 148.5 0.0 3e-43 148.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family ArgoMid PF16487.3 001032358.1_49823001_1 - 0.018 15.1 0.1 0.05 13.7 0.1 1.7 1 0 0 1 1 1 0 Mid domain of argonaute Peptidase_C14 PF00656.20 001032358.1_49823001_1 - 0.055 13.3 0.0 0.074 12.9 0.0 1.4 1 0 0 1 1 1 0 Caspase domain COesterase PF00135.26 001009188.1_22425001_1 - 6.8e-156 520.0 0.0 7.8e-156 519.8 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001009188.1_22425001_1 - 1e-05 25.4 0.1 3.1e-05 23.8 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Cys_knot PF00007.20 001304865.1_01321001_1 - 5.3e-34 116.6 16.8 6.5e-34 116.2 16.8 1.1 1 0 0 1 1 1 1 Cystine-knot domain Defensin_beta_2 PF13841.4 001129772.1_39721001_1 - 1.1e-10 41.7 11.4 1.8e-10 41.0 11.4 1.4 1 0 0 1 1 1 1 Beta defensin AIM5 PF17050.3 001129772.1_39721001_1 - 0.14 12.3 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Altered inheritance of mitochondria 5 Hemopexin PF00045.17 213953.2_49824001_1 - 2.6e-35 120.0 10.5 2.9e-08 33.4 0.1 6.8 7 0 0 7 7 7 5 Hemopexin IL8 PF00048.18 001132340.2_43522001_1 - 6.8e-22 77.3 2.9 6.8e-22 77.3 2.9 2.1 2 1 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like DUF4725 PF15854.3 001132340.2_43522001_1 - 0.096 12.8 0.2 0.096 12.8 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4725) EIIBC-GUT_N PF03612.12 001132340.2_43522001_1 - 2.1 7.9 11.2 3.1 7.4 11.2 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus EOS1 PF12326.6 001132340.2_43522001_2 - 0.023 14.5 0.1 0.023 14.5 0.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein EOS1 PF12326.6 001132340.2_43522001_3 - 0.022 14.6 0.1 0.022 14.6 0.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein Afi1 PF07792.10 001132340.2_43522001_3 - 0.042 14.2 5.4 0.06 13.7 5.4 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking TGFb_propeptide PF00688.16 001314142.1_09023001_1 - 1.3e-39 136.3 0.0 1.6e-39 136.0 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001314142.1_09023001_1 - 1.6e-22 80.2 1.6 3.3e-22 79.2 1.6 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain Sterile PF03015.17 001314142.1_09023001_1 - 0.11 12.6 0.1 0.4 10.8 0.0 1.9 2 0 0 2 2 2 0 Male sterility protein Neur_chan_LBD PF02931.21 008070.3_32929001_2 - 5.6e-49 166.4 0.0 8.3e-49 165.8 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 008070.3_32929001_2 - 2.1e-46 158.8 0.3 5.7e-46 157.4 0.3 1.8 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Cathelicidins PF00666.15 213863.1_49822001_3 - 9.2e-49 163.8 0.2 1.2e-48 163.5 0.2 1.1 1 0 0 1 1 1 1 Cathelicidin Spp-24 PF07448.9 213863.1_49822001_3 - 0.00058 19.8 0.2 0.00094 19.2 0.2 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain AIMP2_LysRS_bd PF16780.3 001159815.1_43525001_2 - 1.9e-09 37.0 0.3 5.5e-09 35.5 0.3 1.8 1 0 0 1 1 1 1 AIMP2 lysyl-tRNA synthetase binding domain IFN-gamma PF00714.15 001304863.1_01322001_1 - 1.3e-72 242.0 4.3 1.5e-72 241.7 4.3 1.0 1 0 0 1 1 1 1 Interferon gamma DUF1987 PF09345.8 001304863.1_01322001_1 - 0.18 11.6 1.5 0.26 11.1 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1987) Serpin PF00079.18 001082197.1_37923001_2 - 9.4e-119 396.9 0.1 1.1e-118 396.7 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Hormone_2 PF00123.18 001281590.1_31321001_3 - 5e-14 51.8 0.2 8e-14 51.2 0.2 1.3 1 0 0 1 1 1 1 Peptide hormone Apolipoprotein PF01442.16 214308.1_49823001_2 - 1.3e-55 188.2 19.8 1.3e-55 188.2 19.8 1.4 2 0 0 2 2 1 1 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.9 214308.1_49823001_2 - 7.2e-05 22.8 8.0 0.051 13.5 4.5 2.8 1 1 2 3 3 3 2 Apolipophorin-III precursor (apoLp-III) DUF883 PF05957.11 214308.1_49823001_2 - 0.00057 20.3 25.2 0.15 12.5 2.4 4.9 1 1 3 4 4 4 2 Bacterial protein of unknown function (DUF883) YtxH PF12732.5 214308.1_49823001_2 - 0.002 18.5 9.0 0.06 13.8 0.3 4.3 2 1 1 3 3 3 1 YtxH-like protein Laminin_I PF06008.12 214308.1_49823001_2 - 0.0021 17.7 0.6 0.0021 17.7 0.6 2.4 2 1 0 2 2 2 1 Laminin Domain I Phage_Mu_Gam PF07352.10 214308.1_49823001_2 - 0.0044 16.8 4.7 2.3 8.0 0.1 3.2 2 1 1 3 3 3 1 Bacteriophage Mu Gam like protein Baculo_PEP_C PF04513.10 214308.1_49823001_2 - 0.0079 16.1 1.7 0.93 9.4 1.0 3.0 2 1 1 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.4 214308.1_49823001_2 - 0.014 14.6 11.1 0.41 9.8 11.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) OmpH PF03938.12 214308.1_49823001_2 - 0.015 15.2 12.9 0.19 11.6 3.7 2.5 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF948 PF06103.9 214308.1_49823001_2 - 0.034 14.3 1.7 2.9 8.1 0.4 3.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Exonuc_VII_L PF02601.13 214308.1_49823001_2 - 0.051 13.0 13.4 0.029 13.8 1.5 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit DUF4618 PF15397.4 214308.1_49823001_2 - 0.06 12.6 0.1 0.06 12.6 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) DUF4795 PF16043.3 214308.1_49823001_2 - 0.099 12.1 13.1 1.5 8.2 0.6 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) DUF1690 PF07956.9 214308.1_49823001_2 - 0.15 12.3 12.9 0.15 12.3 6.6 2.6 2 1 1 3 3 3 0 Protein of Unknown function (DUF1690) DUF1640 PF07798.9 214308.1_49823001_2 - 0.17 11.8 13.4 0.21 11.5 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) DUF2063 PF09836.7 214308.1_49823001_2 - 0.22 11.6 0.9 2.6 8.2 0.1 2.5 1 1 1 2 2 2 0 Putative DNA-binding domain ISG65-75 PF11727.6 214308.1_49823001_2 - 0.37 9.9 5.6 0.97 8.5 1.8 2.3 2 1 0 2 2 2 0 Invariant surface glycoprotein Prominin PF05478.9 214308.1_49823001_2 - 0.51 8.1 4.5 1.5 6.5 4.6 1.7 1 1 0 1 1 1 0 Prominin Phasin PF05597.9 214308.1_49823001_2 - 0.58 10.1 15.1 2.7 7.9 0.7 3.4 1 1 3 4 4 4 0 Poly(hydroxyalcanoate) granule associated protein (phasin) BshC PF10079.7 214308.1_49823001_2 - 0.65 8.5 8.5 4.1 5.9 3.2 2.6 2 1 1 3 3 3 0 Bacillithiol biosynthesis BshC Fib_alpha PF08702.8 214308.1_49823001_2 - 0.72 9.9 7.0 26 4.8 0.3 3.0 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family CpXC PF14353.4 214308.1_49823001_2 - 0.73 9.7 2.8 11 5.9 2.8 2.3 1 1 0 1 1 1 0 CpXC protein ApoO PF09769.7 214308.1_49823001_2 - 0.94 9.3 3.4 9.2 6.1 0.1 3.0 2 1 1 3 3 3 0 Apolipoprotein O Syntaxin_2 PF14523.4 214308.1_49823001_2 - 0.94 9.7 9.3 84 3.5 0.1 3.3 1 1 0 2 2 2 0 Syntaxin-like protein V-ATPase_G PF03179.13 214308.1_49823001_2 - 1 9.8 7.8 0.63 10.5 3.5 2.4 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit COG2 PF06148.9 214308.1_49823001_2 - 2 8.4 10.1 6.7 6.7 0.1 3.4 2 1 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 RPOL_N PF14700.4 214308.1_49823001_2 - 2 7.6 12.2 0.031 13.5 1.1 2.5 1 1 1 2 2 2 0 DNA-directed RNA polymerase N-terminal Spc7 PF08317.9 214308.1_49823001_2 - 2.4 6.8 18.3 0.18 10.5 1.1 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF217 PF02697.12 214308.1_49823001_2 - 2.8 8.6 7.7 17 6.1 0.4 2.9 3 0 0 3 3 3 0 Uncharacterized ACR, COG1753 TBPIP PF07106.11 214308.1_49823001_2 - 4.5 6.9 13.3 5.4 6.6 3.1 3.0 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) MIF4G_like_2 PF09090.9 214308.1_49823001_2 - 6.2 6.0 8.4 7.2 5.8 3.4 2.1 2 0 0 2 2 2 0 MIF4G like KxDL PF10241.7 214308.1_49823001_2 - 7.1 6.8 11.3 11 6.3 1.5 3.7 2 1 1 3 3 3 0 Uncharacterized conserved protein Vps51 PF08700.9 214308.1_49823001_2 - 7.9 6.5 7.0 13 5.8 0.1 3.3 3 1 0 3 3 3 0 Vps51/Vps67 IZUMO PF15005.4 214308.1_49823001_2 - 8.8 6.7 6.1 8.9 6.7 2.7 2.4 2 1 1 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated TetR_C_13 PF16925.3 214308.1_49823001_2 - 9.7 6.0 7.7 4.8 7.0 0.3 3.2 2 2 1 3 3 3 0 Bacterial transcriptional repressor C-terminal Defensin_beta PF00711.17 001110263.1_29622001_1 - 6.8e-09 35.5 8.2 6.8e-09 35.5 8.2 2.2 2 0 0 2 2 2 1 Beta defensin Defensin_beta_2 PF13841.4 001110263.1_29622001_1 - 0.00037 20.8 7.6 0.00086 19.6 7.6 1.7 1 0 0 1 1 1 1 Beta defensin Sperm_Ag_HE2 PF05324.11 001110263.1_29622001_3 - 1.1e-33 115.3 0.7 1.6e-33 114.7 0.7 1.3 1 0 0 1 1 1 1 Sperm antigen HE2 DUF2340 PF10209.7 001131970.2_43522001_1 - 5.2e-42 143.0 0.1 6.5e-42 142.6 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) Cadherin PF00028.15 001082563.2_39729001_2 - 5.3e-83 273.5 0.0 9.8e-18 64.3 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001082563.2_39729001_2 - 2.6e-35 119.9 0.3 1.9e-33 114.0 0.0 4.0 6 0 0 6 6 6 1 Cadherin-like Cadherin_C_2 PF16492.3 001082563.2_39729001_2 - 8.8e-27 93.6 0.1 1.8e-26 92.6 0.1 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_tail PF15974.3 001082563.2_39729001_2 - 2e-25 89.5 3.3 4e-25 88.5 3.3 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region TMEM154 PF15102.4 001082563.2_39729001_2 - 0.075 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family MHC_II_beta PF00969.17 001308577.1_39522001_1 - 4.3e-36 122.8 0.6 6.9e-36 122.1 0.6 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001308577.1_39522001_1 - 9.1e-25 86.8 0.2 2.6e-24 85.4 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001308577.1_39522001_1 - 0.00049 20.5 0.1 0.0011 19.4 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001308577.1_39522001_1 - 0.0058 16.8 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001308577.1_39522001_1 - 0.021 14.9 0.0 0.042 13.9 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain DUF202 PF02656.13 001308577.1_39522001_1 - 0.04 14.2 0.0 0.074 13.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Defensin_beta PF00711.17 001110255.1_29621001_1 - 4e-09 36.2 8.2 4e-09 36.2 8.2 1.7 2 0 0 2 2 2 1 Beta defensin Defensin_beta_2 PF13841.4 001110255.1_29621001_1 - 0.00028 21.2 7.6 0.00052 20.3 7.6 1.5 1 0 0 1 1 1 1 Beta defensin Hormone_1 PF00103.18 001285586.1_09022001_1 - 1.5e-46 158.7 0.0 1.7e-46 158.5 0.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family XTBD PF11952.6 001285586.1_09022001_1 - 0.042 13.5 0.0 0.17 11.5 0.0 2.0 2 1 0 2 2 2 0 XRN-Two Binding Domain, XTBD LRR_9 PF14580.4 001144865.1_39725001_2 - 7.6e-12 44.9 0.0 2.4e-11 43.3 0.0 1.8 1 1 1 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.4 001144865.1_39725001_2 - 1.9e-06 27.4 1.5 1.9e-06 27.4 1.5 2.1 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.5 001144865.1_39725001_2 - 0.00026 21.2 4.6 0.0053 17.0 0.3 3.3 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) zf-H2C2_2 PF13465.4 001132579.1_43528001_1 - 1e-139 449.1 202.1 1.1e-08 34.9 0.2 24.8 25 0 0 25 25 25 21 Zinc-finger double domain zf-C2H2 PF00096.24 001132579.1_43528001_1 - 8.6e-91 293.5 241.1 6.6e-07 29.3 0.4 24.7 26 0 0 26 26 26 21 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001132579.1_43528001_1 - 3.1e-42 139.4 211.4 0.0064 17.1 4.7 23.6 24 0 0 24 24 24 20 C2H2-type zinc finger KRAB PF01352.25 001132579.1_43528001_1 - 9.5e-22 76.3 2.9 1.8e-21 75.4 2.9 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 001132579.1_43528001_1 - 1.8e-19 69.1 164.5 0.062 13.1 1.4 24.0 24 0 0 24 24 24 17 C2H2-type zinc finger C1_1 PF00130.20 001132579.1_43528001_1 - 4.4e-12 45.6 87.7 0.0063 16.3 0.5 14.1 3 2 9 13 13 13 6 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn-ribbon_8 PF09723.8 001132579.1_43528001_1 - 9.1e-08 32.0 141.4 0.014 15.4 6.2 15.2 6 3 14 20 20 20 15 Zinc ribbon domain XPA_N PF01286.16 001132579.1_43528001_1 - 1.2e-06 28.3 111.8 5.1 7.1 0.1 21.5 22 0 0 22 22 22 8 XPA protein N-terminal zf-C2H2_jaz PF12171.6 001132579.1_43528001_1 - 0.011 15.9 133.9 0.34 11.1 0.3 20.7 21 0 0 21 21 21 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 001132579.1_43528001_1 - 0.033 14.4 88.3 0.22 11.7 0.8 11.3 2 1 6 13 13 13 0 zinc-finger-containing domain MACPF PF01823.17 001082255.1_37925001_2 - 5.4e-42 144.1 0.5 9e-42 143.4 0.5 1.4 1 0 0 1 1 1 1 MAC/Perforin domain Ldl_recept_a PF00057.16 001082255.1_37925001_2 - 1.3e-09 38.0 11.9 4.7e-09 36.2 11.9 2.1 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A TSP_1 PF00090.17 001082255.1_37925001_2 - 0.00011 22.2 13.0 0.00011 22.2 13.0 3.2 3 0 0 3 3 3 2 Thrombospondin type 1 domain TMEM190 PF15431.4 001082255.1_37925001_2 - 0.031 14.3 2.5 0.069 13.2 2.5 1.5 1 0 0 1 1 1 0 Transmembrane protein 190 fn2 PF00040.17 001143666.1_39522001_3 - 2.2e-28 98.1 20.9 6.5e-15 55.0 7.5 2.5 2 0 0 2 2 2 2 Fibronectin type II domain KIAA1328 PF15369.4 001134077.1_43529001_2 - 2.2e-26 93.4 13.5 3.3e-26 92.8 13.5 1.2 1 0 0 1 1 1 1 Uncharacterised protein KIAA1328 EAR PF07897.9 001134077.1_43529001_2 - 0.051 13.1 0.1 0.092 12.2 0.1 1.4 1 0 0 1 1 1 0 Ethylene-responsive binding factor-associated repression KIAA1328 PF15369.4 001134077.1_43529001_3 - 3.1e-121 405.0 12.8 4.4e-121 404.6 12.8 1.1 1 0 0 1 1 1 1 Uncharacterised protein KIAA1328 UNC119_bdg PF15435.4 001131569.1_43526001_1 - 8.7e-110 364.7 0.4 1.1e-109 364.4 0.4 1.1 1 0 0 1 1 1 1 UNC119-binding protein C5orf30 homologue DUF4615 PF15393.4 001133765.1_43526001_3 - 2.3e-36 124.9 0.1 4.6e-36 123.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4615) Galanin PF01296.16 213825.2_49823001_2 - 1.1e-06 28.4 1.9 2.2e-06 27.4 1.9 1.5 1 0 0 1 1 1 1 Galanin Sperm_Ag_HE2 PF05324.11 001110262.1_29622001_3 - 1.1e-33 115.2 0.7 1.9e-33 114.5 0.7 1.4 1 0 0 1 1 1 1 Sperm antigen HE2 Defensin_beta PF00711.17 001110262.1_29622001_3 - 3.9e-09 36.2 15.4 7.6e-09 35.3 8.2 2.6 2 0 0 2 2 2 2 Beta defensin Trypsin PF00089.24 001172932.1_09922001_2 - 7.2e-54 182.8 0.0 8.3e-54 182.6 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001172932.1_09922001_2 - 0.00044 21.0 0.0 0.0013 19.5 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S29 PF02907.13 001172932.1_09922001_2 - 0.11 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease ARA70 PF12489.6 001135286.1_43527001_2 - 2.1e-73 244.6 30.5 3.5e-47 159.8 5.1 6.0 3 1 2 5 5 5 4 Nuclear coactivator Serpin PF00079.18 001281628.1_31325001_2 - 1.7e-121 405.9 1.5 2e-121 405.7 1.5 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF531 PF04407.10 001281628.1_31325001_2 - 0.15 12.0 0.0 0.79 9.7 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF531) Cys_knot PF00007.20 001032974.1_32322001_3 - 1.2e-31 109.0 13.0 1.5e-31 108.7 13.0 1.1 1 0 0 1 1 1 1 Cystine-knot domain Defensin_beta_2 PF13841.4 001129753.1_39721001_1 - 3.5e-08 33.7 12.6 5.1e-08 33.1 12.6 1.3 1 0 0 1 1 1 1 Beta defensin LRR_8 PF13855.4 001081839.1_21025001_2 - 5.6e-33 112.4 18.4 1e-13 50.7 1.7 4.3 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 001081839.1_21025001_2 - 9.3e-14 51.1 18.8 0.00016 21.8 0.6 5.6 4 2 1 5 5 5 4 Leucine Rich repeats (2 copies) LRRNT PF01462.16 001081839.1_21025001_2 - 5.8e-12 44.8 8.4 8.4e-11 41.1 2.2 3.7 3 0 0 3 3 3 2 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 001081839.1_21025001_2 - 1.1e-08 34.6 6.9 0.00087 18.7 0.4 3.2 1 1 2 3 3 3 2 Leucine-rich repeat LRR_5 PF13306.4 001081839.1_21025001_2 - 9.7e-05 22.2 0.0 0.00084 19.2 0.0 2.1 1 1 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_1 PF00560.31 001081839.1_21025001_2 - 4.4 8.0 21.4 13 6.6 0.5 7.4 6 2 1 7 7 7 0 Leucine Rich Repeat Sep15_SelM PF08806.9 001145843.1_39724001_2 - 7.9e-22 77.1 0.0 1.4e-21 76.3 0.0 1.4 1 0 0 1 1 1 1 Sep15/SelM redox domain Lipocalin PF00061.21 001082254.1_37922001_2 - 5.9e-13 49.1 0.0 7.2e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Trypsin PF00089.24 001285202.1_29522001_1 - 4e-68 229.4 0.0 4.6e-68 229.2 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001285202.1_29522001_1 - 3.6e-07 31.0 0.0 5.6e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001285202.1_29522001_1 - 0.00053 20.2 0.2 0.0062 16.8 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1986) Clat_adaptor_s PF01217.18 019877.2_32922001_2 - 3.2e-35 121.0 0.4 3.9e-35 120.7 0.4 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain MHC_II_alpha PF00993.18 001113706.1_49823001_3 - 7.4e-36 121.6 0.1 1.1e-35 121.0 0.1 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001113706.1_49823001_3 - 1.2e-27 94.9 0.7 2.5e-27 93.9 0.7 1.6 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001113706.1_49823001_3 - 2.5e-22 79.0 0.0 4e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001113706.1_49823001_3 - 0.00077 19.9 0.0 0.0015 19.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001113706.1_49823001_3 - 0.039 13.7 0.0 0.068 12.9 0.0 1.3 1 0 0 1 1 1 0 Marek's disease glycoprotein A Carb_anhydrase PF00194.19 019174.3_45723001_3 - 3.6e-84 282.2 2.9 4.1e-84 282.0 2.9 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase GSG-1 PF07803.9 019174.3_45723001_3 - 0.1 12.4 0.1 0.35 10.7 0.0 1.9 2 0 0 2 2 2 0 GSG1-like protein Defensin_beta PF00711.17 001009063.1_39721001_2 - 2.5e-09 36.9 9.4 2.5e-09 36.9 9.4 1.6 2 0 0 2 2 2 1 Beta defensin Defensin_beta_2 PF13841.4 001009063.1_39721001_2 - 0.00065 20.0 8.8 0.0014 19.0 8.8 1.6 1 0 0 1 1 1 1 Beta defensin Lipocalin PF00061.21 001009257.1_39522001_1 - 3.1e-34 118.1 0.0 3.6e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Inhibitor_I29 PF08246.10 007796.2_32923001_2 - 3.1e-14 53.0 4.4 4.6e-14 52.5 4.4 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) IL6 PF00489.15 001285640.1_09022001_1 - 3.6e-87 290.6 3.1 4e-87 290.5 3.1 1.0 1 0 0 1 1 1 1 Interleukin-6/G-CSF/MGF family IL23 PF16649.3 001285640.1_09022001_1 - 8.8e-05 22.5 0.1 0.00012 22.0 0.1 1.2 1 0 0 1 1 1 1 Interleukin 23 subunit alpha GCSF PF16647.3 001285640.1_09022001_1 - 0.003 17.3 0.0 0.0041 16.8 0.0 1.2 1 0 0 1 1 1 1 Granulocyte colony-stimulating factor Sec16 PF12932.5 001285640.1_09022001_1 - 0.023 15.2 0.1 0.057 13.9 0.0 1.6 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region ZapB PF06005.10 001285640.1_09022001_1 - 0.63 10.4 5.2 1.7 9.0 0.3 2.5 2 1 0 2 2 2 0 Cell division protein ZapB LRRFIP PF09738.7 001285640.1_09022001_1 - 1.7 8.0 5.7 4.4 6.6 0.2 2.1 2 0 0 2 2 2 0 LRRFIP family Cys_knot PF00007.20 001048015.1_22421001_1 - 1.3e-33 115.3 13.5 1.6e-33 115.0 13.5 1.1 1 0 0 1 1 1 1 Cystine-knot domain Ig_3 PF13927.4 001109882.1_45724001_2 - 4.5e-25 87.9 2.0 1.5e-10 41.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 001109882.1_45724001_2 - 1.2e-18 66.8 1.6 9.4e-09 35.1 0.0 3.2 3 1 1 4 4 4 2 Immunoglobulin I-set domain ig PF00047.23 001109882.1_45724001_2 - 1.9e-16 59.9 2.4 8.8e-09 35.3 0.0 3.5 3 1 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 001109882.1_45724001_2 - 4.4e-13 49.2 0.1 0.00011 22.3 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 001109882.1_45724001_2 - 3.6e-07 30.2 2.0 0.003 17.5 0.1 3.8 3 2 0 3 3 3 2 Immunoglobulin V-set domain Ig_5 PF16681.3 001109882.1_45724001_2 - 9.6e-05 22.6 0.3 6.4 7.1 0.0 4.0 3 2 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set_CD47 PF08204.9 001109882.1_45724001_2 - 0.054 13.3 0.1 0.27 11.1 0.0 2.1 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain C2-set PF05790.13 001109882.1_45724001_2 - 0.14 12.3 0.0 1.9 8.6 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin C2-set domain TLV_coat PF00429.17 001304543.1_43526001_3 - 8.4e-67 226.0 8.0 3.4e-66 224.0 7.5 1.8 1 1 1 2 2 2 2 ENV polyprotein (coat polyprotein) SelP_N PF04592.12 001115115.1_39725001_2 - 8e-105 349.3 3.8 8e-105 349.3 3.8 1.5 1 1 1 2 2 2 2 Selenoprotein P, N terminal region SelP_C PF04593.12 001115115.1_39725001_2 - 8.5e-44 148.7 14.6 8.5e-44 148.7 14.6 1.8 2 0 0 2 2 2 1 Selenoprotein P, C terminal region Defensin_beta PF00711.17 001110236.1_39722001_3 - 3.1e-09 36.6 9.4 3.1e-09 36.6 9.4 1.7 2 0 0 2 2 2 1 Beta defensin Defensin_beta_2 PF13841.4 001110236.1_39722001_3 - 0.00079 19.7 8.8 0.0017 18.6 8.8 1.6 1 0 0 1 1 1 1 Beta defensin Lectin_C PF00059.19 001082229.1_37926001_1 - 5.2e-21 75.3 0.0 8.9e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 001082229.1_37926001_1 - 5.1e-10 38.8 33.6 4.2e-05 23.1 20.0 2.5 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) A2M_comp PF07678.12 001173061.1_09929001_1 - 6.1e-95 317.3 0.2 9.4e-95 316.7 0.2 1.3 1 0 0 1 1 1 1 A-macroglobulin complement component A2M_N_2 PF07703.12 001173061.1_09929001_1 - 4.3e-31 108.0 0.1 5.3e-25 88.2 0.0 3.6 3 0 0 3 3 3 2 Alpha-2-macroglobulin family N-terminal region A2M PF00207.20 001173061.1_09929001_1 - 2.7e-29 100.7 0.5 1.1e-28 98.8 0.2 2.3 2 0 0 2 2 2 1 Alpha-2-macroglobulin family A2M_recep PF07677.12 001173061.1_09929001_1 - 4.6e-25 88.1 2.1 1.2e-24 86.7 0.9 2.4 2 0 0 2 2 2 1 A-macroglobulin receptor A2M_N PF01835.17 001173061.1_09929001_1 - 6.2e-18 64.9 0.0 2.4e-17 63.0 0.0 2.1 1 0 0 1 1 1 1 MG2 domain Thiol-ester_cl PF10569.7 001173061.1_09929001_1 - 3.5e-16 58.5 1.9 8.1e-16 57.3 1.9 1.7 1 0 0 1 1 1 1 Alpha-macro-globulin thiol-ester bond-forming region SVA PF05326.9 001173061.1_09929001_1 - 0.0021 17.9 0.0 0.0088 15.9 0.0 2.1 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) Lig_chan PF00060.24 001184994.3_39729001_2 - 1.9e-59 199.7 0.1 3.3e-59 198.9 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel ANF_receptor PF01094.26 001184994.3_39729001_2 - 4.9e-59 200.1 0.1 7.7e-59 199.4 0.1 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan-Glu_bd PF10613.7 001184994.3_39729001_2 - 3e-45 153.0 0.1 5.8e-45 152.0 0.1 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001184994.3_39729001_2 - 1e-23 83.8 0.0 1.7e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 TLV_coat PF00429.17 001305096.1_08027001_2 - 3.2e-65 220.8 5.7 7.7e-62 209.6 2.7 2.3 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) CwsA PF10814.6 001305096.1_08027001_2 - 0.059 13.4 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Cell wall synthesis protein CwsA DUF4042 PF13251.4 001133234.1_43528001_1 - 4.2e-69 231.8 5.9 7.5e-68 227.7 1.1 4.2 4 0 0 4 4 4 1 Domain of unknown function (DUF4042) HEAT_2 PF13646.4 001133234.1_43528001_1 - 3.1e-18 65.8 5.3 3e-05 24.2 0.0 7.5 5 3 2 7 7 7 6 HEAT repeats HEAT PF02985.20 001133234.1_43528001_1 - 7.9e-14 50.4 18.2 0.018 15.1 0.0 9.7 11 0 0 11 11 11 3 HEAT repeat HEAT_EZ PF13513.4 001133234.1_43528001_1 - 2.4e-11 43.7 18.7 0.0012 19.1 0.3 8.5 7 2 2 9 9 9 6 HEAT-like repeat Cnd1 PF12717.5 001133234.1_43528001_1 - 1.9e-05 24.6 6.1 4.1 7.3 0.2 5.3 5 1 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Arm PF00514.21 001133234.1_43528001_1 - 7e-05 22.6 18.5 0.44 10.5 0.2 6.7 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.18 001133234.1_43528001_1 - 7.4e-05 21.4 11.7 0.017 13.5 0.0 5.0 4 1 1 5 5 5 2 Adaptin N terminal region HEAT_PBS PF03130.14 001133234.1_43528001_1 - 0.0038 17.6 0.2 1.6 9.5 0.0 4.5 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat DUF3636 PF12331.6 001133234.1_43528001_1 - 0.028 14.1 0.1 8.5 6.1 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3636) PUL PF08324.9 001133234.1_43528001_1 - 0.43 9.7 4.7 3.7 6.6 0.1 3.4 3 1 1 4 4 4 0 PUL domain I-set PF07679.14 053848.1_45725001_2 - 3.8e-41 138.9 0.3 1e-15 57.4 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 053848.1_45725001_2 - 8.3e-36 122.3 0.9 9.2e-14 51.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 053848.1_45725001_2 - 2.9e-31 107.3 2.1 3.3e-15 55.9 0.1 3.8 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 053848.1_45725001_2 - 5.1e-27 93.9 1.1 1.5e-10 41.1 0.0 3.8 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 053848.1_45725001_2 - 8e-13 48.4 5.4 3.7e-07 30.1 0.1 4.9 3 2 1 4 4 4 3 Immunoglobulin V-set domain Izumo-Ig PF16706.3 053848.1_45725001_2 - 1.6e-06 28.0 0.6 0.048 13.6 0.1 3.9 3 1 0 3 3 3 2 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.9 053848.1_45725001_2 - 0.0096 15.8 0.7 0.76 9.6 0.3 3.0 3 0 0 3 3 3 1 CD47 immunoglobulin-like domain Lipocalin PF00061.21 001204777.1_22422001_1 - 1.4e-27 96.6 0.6 1.6e-27 96.3 0.6 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Tmemb_cc2 PF10267.7 001131731.1_43529001_3 - 1.4e-158 528.1 11.5 1.6e-158 527.9 11.5 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein DUF2407_C PF13373.4 001131731.1_43529001_3 - 0.066 13.3 0.1 0.066 13.3 0.1 1.6 2 0 0 2 2 2 0 DUF2407 C-terminal domain DUF2678 PF10856.6 001131731.1_43529001_3 - 0.36 10.7 4.6 0.57 10.0 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2678) Allexi_40kDa PF05549.9 001131731.1_43529001_3 - 6.7 6.0 11.9 1.8 7.9 1.5 2.5 2 0 0 2 2 2 0 Allexivirus 40kDa protein Hormone_6 PF00236.16 001048158.1_22421001_1 - 1.7e-52 175.2 11.5 2.3e-52 174.8 11.5 1.2 1 0 0 1 1 1 1 Glycoprotein hormone DUF1218 PF06749.10 001048158.1_22421001_1 - 0.053 13.9 7.1 0.3 11.5 4.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1218) Cadherin PF00028.15 001133037.1_43529001_1 - 6.2e-81 266.8 0.0 5e-19 68.4 0.0 6.4 5 1 1 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001133037.1_43529001_1 - 1.6e-63 212.8 4.7 3e-63 211.9 4.7 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001133037.1_43529001_1 - 1.7e-32 110.9 1.9 1.5e-28 98.3 0.1 4.6 5 0 0 5 5 5 2 Cadherin-like Cadherin_C_2 PF16492.3 001133037.1_43529001_1 - 2.7e-06 27.9 0.3 8.4e-06 26.3 0.3 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001133037.1_43529001_1 - 0.00017 21.4 0.6 19 5.2 0.0 4.5 4 0 0 4 4 4 2 Cadherin-like 2OG-FeII_Oxy_3 PF13640.4 178101.3_45726001_1 - 7.5e-06 26.6 0.1 1.6e-05 25.5 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Anp1 PF03452.12 178101.3_45726001_1 - 0.00021 20.7 0.0 0.77 9.0 0.0 2.9 3 0 0 3 3 3 2 Anp1 Glyco_tranf_2_3 PF13641.4 178101.3_45726001_1 - 0.056 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Pkinase_Tyr PF07714.15 001131199.1_43526001_1 - 7.2e-71 238.4 0.0 1e-70 237.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001131199.1_43526001_1 - 7.4e-26 90.9 0.0 1.1e-25 90.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 001131199.1_43526001_1 - 6.2e-08 32.8 0.0 1.5e-07 31.5 0.0 1.7 2 0 0 2 2 2 1 Fibronectin type III domain Sperm_Ag_HE2 PF05324.11 001110235.1_39722001_2 - 1.1e-33 115.3 2.0 1.5e-33 114.8 1.8 1.4 1 1 0 1 1 1 1 Sperm antigen HE2 Defensin_beta PF00711.17 001110235.1_39722001_3 - 4.3e-09 36.1 9.4 4.3e-09 36.1 9.4 2.1 2 0 0 2 2 2 1 Beta defensin Defensin_beta_2 PF13841.4 001110235.1_39722001_3 - 0.00095 19.5 8.8 0.0024 18.2 8.8 1.7 1 0 0 1 1 1 1 Beta defensin Serum_albumin PF00273.18 001173105.1_09924001_1 - 2.4e-158 522.3 42.8 1.6e-56 190.8 11.8 3.0 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.8 001173105.1_09924001_1 - 1.1e-06 28.3 16.7 0.26 11.2 0.2 5.9 6 0 0 6 6 6 4 Vitamin D binding protein, domain III KAR PF15222.4 052802.1_45722001_2 - 2e-50 169.2 14.5 2.6e-50 168.9 14.5 1.1 1 0 0 1 1 1 1 Kidney androgen-regulated Cys_knot PF00007.20 001009798.1_39524001_2 - 5.1e-33 113.4 16.5 9.8e-33 112.5 16.5 1.5 1 0 0 1 1 1 1 Cystine-knot domain Interferon PF00143.17 001083595.3_21025001_3 - 5e-64 215.2 0.2 1.3e-63 213.8 0.2 1.8 1 0 0 1 1 1 1 Interferon alpha/beta domain LRR_8 PF13855.4 213958.1_49827001_1 - 1.2e-84 277.9 79.0 8.7e-13 47.7 4.1 15.3 8 4 8 16 16 16 16 Leucine rich repeat LRR_4 PF12799.5 213958.1_49827001_1 - 1.2e-46 155.5 60.8 5.3e-06 26.5 0.5 16.0 8 4 9 18 18 18 17 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 213958.1_49827001_1 - 3.5e-20 69.2 66.2 2.2 8.9 0.0 22.9 23 3 2 25 25 25 7 Leucine Rich Repeat LRR_6 PF13516.4 213958.1_49827001_1 - 1.2e-07 31.1 76.7 1.2 9.3 0.0 20.1 24 0 0 24 24 24 6 Leucine Rich repeat TIR PF01582.18 213958.1_49827001_1 - 5.7e-07 29.4 0.0 9.5e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 TIR domain LRR_9 PF14580.4 213958.1_49827001_1 - 8.6e-06 25.2 18.0 0.12 11.7 0.2 6.5 6 2 1 7 7 7 4 Leucine-rich repeat FNIP PF05725.10 213958.1_49827001_1 - 0.0028 17.6 14.6 0.26 11.4 0.2 4.8 4 1 0 4 4 4 2 FNIP Repeat YiaAB PF05360.12 213958.1_49827001_1 - 0.22 11.7 1.2 0.58 10.3 1.2 1.7 1 0 0 1 1 1 0 yiaA/B two helix domain Lipocalin PF00061.21 001205185.1_09922001_2 - 2.4e-21 76.3 0.2 2.8e-21 76.1 0.2 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family DUF4998 PF16389.3 001205185.1_09922001_2 - 0.023 14.2 0.0 0.033 13.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function E1_DerP2_DerF2 PF02221.13 001081912.1_21022001_1 - 2.9e-33 115.0 0.3 3.4e-33 114.8 0.3 1.1 1 0 0 1 1 1 1 ML domain DUF1091 PF06477.11 001081912.1_21022001_1 - 0.021 15.1 0.1 0.036 14.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1091) Interferon PF00143.17 001123399.1_39522001_3 - 6.6e-64 214.8 0.5 8e-64 214.5 0.5 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain LisH PF08513.9 001123399.1_39522001_3 - 0.016 15.0 0.1 0.043 13.7 0.1 1.7 1 0 0 1 1 1 0 LisH DUF2362 PF10154.7 001131666.1_43528001_3 - 3.8e-215 715.4 9.3 4.8e-215 715.1 9.3 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) RBP_receptor PF14752.4 001135383.2_43526001_2 - 6.9e-257 853.8 5.4 8.1e-257 853.6 5.4 1.0 1 0 0 1 1 1 1 Retinol binding protein receptor Peptidase_M19 PF01244.19 001101697.1_37923001_1 - 9.6e-116 386.3 0.0 1.2e-115 386.0 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) IRK PF01007.18 001134032.2_43526001_1 - 1.1e-134 448.4 1.7 1.5e-134 448.0 1.7 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 001134032.2_43526001_1 - 0.047 13.5 2.7 0.096 12.5 2.7 1.5 1 0 0 1 1 1 0 Ion channel Peptidase_U32 PF01136.17 001190434.1_37923001_2 - 4.8 6.1 5.8 7.1 5.6 5.8 1.1 1 0 0 1 1 1 0 Peptidase family U32 MHC_I PF00129.16 001190434.1_37923001_3 - 1.6e-90 301.4 0.5 2.1e-90 301.0 0.5 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001190434.1_37923001_3 - 7.8e-17 61.4 0.0 1.5e-16 60.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001190434.1_37923001_3 - 1e-06 28.4 2.1 2.1e-06 27.4 2.1 1.5 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001190434.1_37923001_3 - 3.5e-05 24.2 0.3 0.0065 16.9 0.1 2.6 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001190434.1_37923001_3 - 0.00012 21.9 0.1 0.00026 20.9 0.1 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Trp_oprn_chp PF09534.8 001190434.1_37923001_3 - 0.00034 20.3 0.1 0.34 10.6 0.0 2.4 2 0 0 2 2 2 2 Tryptophan-associated transmembrane protein (Trp_oprn_chp) ig PF00047.23 001190434.1_37923001_3 - 0.0039 17.2 0.0 0.007 16.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain DUF357 PF04010.11 001190434.1_37923001_3 - 0.026 14.4 0.0 0.06 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF357) Ig_2 PF13895.4 001190434.1_37923001_3 - 0.049 13.9 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain Protocadherin PF08374.9 001190434.1_37923001_3 - 0.14 12.0 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Protocadherin Podoplanin PF05808.9 001190434.1_37923001_3 - 1.6 8.7 3.2 3.8 7.5 3.2 1.5 1 0 0 1 1 1 0 Podoplanin UDPGT PF00201.16 173323.1_45724001_3 - 3.8e-233 774.7 0.0 4.7e-233 774.3 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 173323.1_45724001_3 - 7.8e-05 22.6 0.0 0.00012 21.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 173323.1_45724001_3 - 0.064 13.1 0.0 0.23 11.3 0.0 1.8 1 1 0 1 1 1 0 Glycosyltransferase Family 4 TGF_beta PF00019.18 001142888.2_39524001_1 - 1.7e-26 93.0 0.3 1.7e-26 93.0 0.3 2.1 2 0 0 2 2 2 1 Transforming growth factor beta like domain Galanin PF01296.16 001348949.1_49822001_2 - 1.1e-06 28.3 1.9 2e-06 27.5 1.9 1.4 1 0 0 1 1 1 1 Galanin RAMP PF04901.11 214199.2_49822001_2 - 4.9e-46 155.1 0.0 6.4e-46 154.8 0.0 1.2 1 0 0 1 1 1 1 Receptor activity modifying family DUF4594 PF15266.4 001133825.1_43529001_2 - 1.7e-61 207.6 21.6 1.7e-61 207.6 21.6 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4594) Rrn6 PF10214.7 001133825.1_43529001_2 - 7.7 4.7 7.0 6.7 4.9 4.9 1.7 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor GMAP PF06540.9 033237.1_45722001_1 - 2.1e-28 98.0 0.1 2.8e-28 97.6 0.1 1.2 1 0 0 1 1 1 1 Galanin message associated peptide (GMAP) Galanin PF01296.16 033237.1_45722001_1 - 7.3e-22 76.9 2.5 1.2e-21 76.2 2.5 1.4 1 0 0 1 1 1 1 Galanin Pkinase PF00069.23 001133622.1_43525001_1 - 3.6e-64 216.5 0.0 4.5e-64 216.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001133622.1_43525001_1 - 3.4e-33 114.9 0.0 4.7e-33 114.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 001133622.1_43525001_1 - 7.1e-15 54.5 6.6 1.3e-14 53.6 6.6 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.22 001133622.1_43525001_1 - 6.5e-06 26.6 2.1 1.4e-05 25.6 2.1 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 001133622.1_43525001_1 - 5.2e-05 22.6 0.0 9.2e-05 21.8 0.0 1.4 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.4 001133622.1_43525001_1 - 0.043 13.3 0.2 1.3 8.5 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 001133622.1_43525001_1 - 0.054 12.7 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family C1_2 PF03107.14 001133622.1_43525001_1 - 0.058 13.6 2.4 0.12 12.6 2.4 1.5 1 0 0 1 1 1 0 C1 domain DZR PF12773.5 001133622.1_43525001_1 - 0.13 12.1 1.5 0.36 10.8 1.5 1.7 1 0 0 1 1 1 0 Double zinc ribbon APH PF01636.21 001133622.1_43525001_1 - 0.16 11.7 0.1 0.16 11.7 0.1 3.1 3 1 1 4 4 4 0 Phosphotransferase enzyme family Lipocalin PF00061.21 001082258.2_37922001_3 - 2.5e-23 82.7 0.0 3e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.10 001082258.2_37922001_3 - 5.5e-23 81.4 0.0 7.4e-23 81.0 0.0 1.2 1 0 0 1 1 1 1 Lipocalin-like domain Triabin PF03973.11 001082258.2_37922001_3 - 0.00016 21.5 0.1 0.00025 20.8 0.1 1.4 1 1 0 1 1 1 1 Triabin SAA PF00277.16 001082327.2_37922001_3 - 1.2e-52 176.5 3.4 1.5e-52 176.2 3.4 1.1 1 0 0 1 1 1 1 Serum amyloid A protein ANF_receptor PF01094.26 001184995.3_39729001_2 - 4.8e-59 200.1 0.1 7.7e-59 199.4 0.1 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 001184995.3_39729001_2 - 1.2e-58 197.1 0.1 2.1e-58 196.2 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 001184995.3_39729001_2 - 3e-45 153.0 0.1 5.8e-45 152.0 0.1 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001184995.3_39729001_2 - 6.5e-24 84.5 0.0 1.1e-23 83.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Sperm_Ag_HE2 PF05324.11 001110259.1_29622001_3 - 9.6e-34 115.5 0.7 1.7e-33 114.7 0.7 1.4 1 0 0 1 1 1 1 Sperm antigen HE2 Defensin_beta PF00711.17 001110259.1_29622001_3 - 5.9e-10 38.9 17.3 7e-09 35.4 8.2 2.5 2 0 0 2 2 2 2 Beta defensin Defensin_beta_2 PF13841.4 001110259.1_29622001_3 - 0.0009 19.5 7.6 0.0009 19.5 7.6 2.2 2 0 0 2 2 2 1 Beta defensin DUF4536 PF15055.4 001109374.1_45726001_2 - 0.07 13.2 0.7 0.16 12.1 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4536) HTH_1 PF00126.25 001109374.1_45726001_2 - 0.17 11.8 1.0 0.39 10.6 0.2 2.1 1 1 1 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family LRR_8 PF13855.4 001109374.1_45726001_3 - 2e-47 158.6 18.0 4.3e-15 55.1 0.4 5.2 4 1 1 5 5 5 4 Leucine rich repeat LRR_4 PF12799.5 001109374.1_45726001_3 - 1.2e-19 69.8 14.8 1.8e-05 24.8 0.1 6.4 5 1 0 6 6 6 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001109374.1_45726001_3 - 1.5e-16 60.4 0.0 2.8e-07 30.4 0.0 2.3 1 1 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001109374.1_45726001_3 - 8.7e-11 41.5 1.9 9.2e-06 25.1 0.3 3.1 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.4 001109374.1_45726001_3 - 3.7e-07 29.6 7.5 6.2 7.0 0.0 7.7 8 0 0 8 8 8 2 Leucine Rich repeat LRR_1 PF00560.31 001109374.1_45726001_3 - 1.7e-05 24.5 13.5 15 6.4 0.1 8.3 7 1 0 7 7 7 2 Leucine Rich Repeat HemY_N PF07219.11 001109374.1_45726001_3 - 0.013 15.5 0.4 0.026 14.6 0.4 1.5 1 0 0 1 1 1 0 HemY protein N-terminus UL97 PF06734.10 001109374.1_45726001_3 - 0.017 14.9 0.1 0.037 13.8 0.1 1.5 1 0 0 1 1 1 0 UL97 ISK_Channel PF02060.13 001132604.1_43527001_3 - 4.4e-61 203.9 0.0 6.3e-61 203.3 0.0 1.2 1 0 0 1 1 1 1 Slow voltage-gated potassium channel Hormone_2 PF00123.18 022670.2_45721001_1 - 2.4e-07 30.5 0.0 3.7e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Peptide hormone Cys_knot PF00007.20 001071814.1_39721001_1 - 1.1e-33 115.6 16.6 1.3e-33 115.3 16.6 1.1 1 0 0 1 1 1 1 Cystine-knot domain Peptidase_M2 PF01401.16 001171069.1_37925001_1 - 7.7e-260 863.3 0.5 9e-260 863.0 0.5 1.0 1 0 0 1 1 1 1 Angiotensin-converting enzyme 7tm_1 PF00001.19 214449.1_49825001_2 - 3.3e-29 101.8 22.7 5.2e-29 101.2 22.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.4 214449.1_49825001_2 - 2.3e-18 65.5 3.8 2.4e-05 23.8 0.3 4.6 3 2 1 4 4 4 4 Leucine rich repeat LRR_5 PF13306.4 214449.1_49825001_2 - 1.3e-13 50.9 10.2 4.8e-08 32.9 0.7 3.2 1 1 1 3 3 3 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 214449.1_49825001_2 - 0.0071 16.6 3.4 1.1 9.7 0.2 4.1 3 2 1 4 4 4 1 Leucine Rich repeats (2 copies) Comm PF15957.3 214449.1_49825001_2 - 0.1 12.8 0.9 0.3 11.3 0.9 1.8 1 0 0 1 1 1 0 Commissureless Myelin_MBP PF01669.15 001133619.1_43525001_3 - 2.7e-70 235.7 8.6 4.5e-70 235.0 8.6 1.4 1 0 0 1 1 1 1 Myelin basic protein Peptidase_M10 PF00413.22 001082793.1_37924001_3 - 1.4e-57 193.8 0.0 2.4e-57 193.1 0.0 1.4 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 001082793.1_37924001_3 - 3.3e-55 183.7 16.6 3.2e-14 52.5 0.3 4.5 4 0 0 4 4 4 4 Hemopexin DUF3377 PF11857.6 001082793.1_37924001_3 - 1.4e-24 85.7 0.0 2.4e-24 84.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) PG_binding_1 PF01471.16 001082793.1_37924001_3 - 1.9e-11 43.9 0.1 4.4e-11 42.7 0.1 1.6 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 001082793.1_37924001_3 - 0.00057 19.4 0.8 0.34 10.4 0.0 2.2 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Peptidase_M54 PF07998.9 001082793.1_37924001_3 - 0.0059 16.5 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M54 Metallopep PF12044.6 001082793.1_37924001_3 - 0.023 13.2 0.0 0.034 12.6 0.0 1.1 1 0 0 1 1 1 0 Putative peptidase family DUF4953 PF16313.3 001082793.1_37924001_3 - 0.027 13.6 0.1 0.043 12.9 0.1 1.2 1 0 0 1 1 1 0 Met-zincin Reprolysin_3 PF13582.4 001082793.1_37924001_3 - 0.085 13.2 0.2 0.16 12.4 0.2 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like HTH_17 PF12728.5 001082793.1_37924001_3 - 0.1 12.7 0.0 0.36 10.9 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain Peptidase_M66 PF10462.7 001082793.1_37924001_3 - 0.12 11.1 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Peptidase M66 SKG6 PF08693.8 001082793.1_37924001_3 - 0.16 11.3 3.8 0.34 10.2 3.8 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Reprolysin_5 PF13688.4 001082793.1_37924001_3 - 0.23 11.4 0.0 0.36 10.8 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 TadE PF07811.10 001082793.1_37924001_3 - 2.2 8.5 6.2 0.8 9.9 3.2 1.8 2 0 0 2 2 2 0 TadE-like protein SAA PF00277.16 001082392.1_37922001_3 - 1.9e-52 175.9 2.4 2.6e-52 175.5 2.4 1.2 1 0 0 1 1 1 1 Serum amyloid A protein MHC_I PF00129.16 001099766.1_21024001_2 - 6.2e-93 309.2 0.2 8.5e-93 308.7 0.2 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001099766.1_21024001_2 - 4.9e-17 62.0 0.0 1.2e-16 60.8 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001099766.1_21024001_2 - 4.1e-08 32.9 15.9 5.1e-08 32.6 4.3 2.6 2 0 0 2 2 2 2 MHC_I C-terminus C2-set_2 PF08205.10 001099766.1_21024001_2 - 2.6e-06 27.3 0.1 5.3e-06 26.3 0.1 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 001099766.1_21024001_2 - 5.4e-05 23.6 0.4 0.29 11.6 0.0 2.5 1 1 1 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001099766.1_21024001_2 - 0.008 16.4 0.0 0.025 14.8 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001099766.1_21024001_2 - 0.018 15.1 0.0 0.036 14.1 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain DAP10 PF07213.9 001099766.1_21024001_2 - 0.07 13.0 0.3 0.16 11.8 0.3 1.5 1 0 0 1 1 1 0 DAP10 membrane protein IFN-gamma PF00714.15 001257226.1_08022001_1 - 2.3e-68 228.2 2.2 2.9e-68 227.9 2.2 1.0 1 0 0 1 1 1 1 Interferon gamma API5 PF05918.9 001257226.1_08022001_1 - 0.0047 15.7 0.9 0.0081 14.9 0.4 1.5 1 1 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) Tup_N PF08581.8 001257226.1_08022001_1 - 0.095 12.9 1.9 0.16 12.2 1.0 1.8 2 1 0 2 2 2 0 Tup N-terminal Vps53_N PF04100.10 001133283.1_43525001_2 - 3.4e-175 582.4 0.3 6e-175 581.6 0.3 1.4 1 0 0 1 1 1 1 Vps53-like, N-terminal Vps54_N PF10475.7 001133283.1_43525001_2 - 2.8e-08 33.3 1.1 2.8e-08 33.3 1.1 2.2 2 1 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex Spc7 PF08317.9 001133283.1_43525001_2 - 2e-05 23.5 3.1 3.9e-05 22.6 3.1 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein Sec8_exocyst PF04048.12 001133283.1_43525001_2 - 0.0046 16.7 0.8 0.012 15.4 0.8 1.7 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain Laminin_II PF06009.10 001133283.1_43525001_2 - 0.0061 16.4 3.4 0.0061 16.4 3.4 2.2 2 0 0 2 2 2 1 Laminin Domain II GrpE PF01025.17 001133283.1_43525001_2 - 0.0067 16.0 1.1 0.02 14.5 1.1 1.8 1 0 0 1 1 1 1 GrpE NBD94 PF16830.3 001133283.1_43525001_2 - 0.02 15.1 3.9 0.06 13.6 3.9 1.8 1 0 0 1 1 1 0 Nucleotide-Binding Domain 94 of RH TBPIP PF07106.11 001133283.1_43525001_2 - 0.022 14.4 3.3 0.053 13.2 3.3 1.6 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) LXG PF04740.10 001133283.1_43525001_2 - 0.035 13.7 2.9 0.13 11.8 3.0 1.8 1 1 0 1 1 1 0 LXG domain of WXG superfamily DUF4413 PF14372.4 001133283.1_43525001_2 - 0.047 13.9 0.3 0.29 11.4 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4413) ATG16 PF08614.9 001133283.1_43525001_2 - 0.08 13.0 1.6 0.24 11.4 1.6 1.8 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Sec34 PF04136.13 001133283.1_43525001_2 - 0.085 12.6 2.2 0.34 10.7 1.6 2.3 2 0 0 2 2 2 0 Sec34-like family Tropomyosin PF00261.18 001133283.1_43525001_2 - 0.087 12.1 4.6 0.042 13.1 1.4 2.1 3 0 0 3 3 3 0 Tropomyosin MCPsignal PF00015.19 001133283.1_43525001_2 - 0.12 12.0 3.5 0.08 12.6 0.7 2.0 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Vps51 PF08700.9 001133283.1_43525001_2 - 0.18 11.8 7.7 0.092 12.7 1.5 3.2 3 1 1 4 4 2 0 Vps51/Vps67 DUF1664 PF07889.10 001133283.1_43525001_2 - 0.2 11.5 11.4 0.65 9.9 3.2 4.3 3 2 2 5 5 5 0 Protein of unknown function (DUF1664) BRE1 PF08647.9 001133283.1_43525001_2 - 0.22 11.5 4.5 0.68 9.9 4.5 1.8 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase COG5 PF10392.7 001133283.1_43525001_2 - 0.44 10.6 3.4 0.28 11.2 0.9 2.0 2 0 0 2 2 1 0 Golgi transport complex subunit 5 HrpB7 PF09486.8 001133283.1_43525001_2 - 0.55 10.5 3.8 1.3 9.2 2.2 2.4 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) NEP PF10167.7 001133283.1_43525001_2 - 0.59 10.0 2.8 2.7 7.8 0.6 2.9 3 0 0 3 3 2 0 Uncharacterised conserved protein XhlA PF10779.7 001133283.1_43525001_2 - 0.75 9.9 11.4 0.039 14.0 2.8 2.8 3 0 0 3 3 2 0 Haemolysin XhlA BLOC1_2 PF10046.7 001133283.1_43525001_2 - 0.77 10.0 5.5 1.7 8.9 2.1 3.0 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prefoldin PF02996.15 001133283.1_43525001_2 - 0.77 9.5 5.6 16 5.3 1.5 3.6 1 1 2 3 3 3 0 Prefoldin subunit Syntaxin_2 PF14523.4 001133283.1_43525001_2 - 1.1 9.5 6.5 14 6.0 6.4 2.8 1 1 0 1 1 1 0 Syntaxin-like protein COG2 PF06148.9 001133283.1_43525001_2 - 1.2 9.1 6.0 1.9 8.4 2.9 2.9 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF5082 PF16888.3 001133283.1_43525001_2 - 1.9 8.7 6.3 20 5.4 3.4 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) Latarcin PF10279.7 001133283.1_43525001_2 - 2.1 8.7 4.0 3.1 8.1 2.7 2.0 1 1 1 2 2 1 0 Latarcin precursor CREPT PF16566.3 001133283.1_43525001_2 - 3.3 7.7 7.4 1.6 8.8 1.5 3.2 3 1 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour ING PF12998.5 001133283.1_43525001_2 - 3.9 8.0 10.0 0.37 11.2 4.3 2.3 3 0 0 3 3 1 0 Inhibitor of growth proteins N-terminal histone-binding Seryl_tRNA_N PF02403.20 001133283.1_43525001_2 - 5.3 7.2 9.9 0.31 11.2 3.4 2.4 3 0 0 3 3 1 0 Seryl-tRNA synthetase N-terminal domain Snf7 PF03357.19 001133283.1_43525001_2 - 7.5 6.0 12.7 0.4 10.1 5.7 2.4 2 0 0 2 2 2 0 Snf7 DUF948 PF06103.9 001133283.1_43525001_2 - 9.8 6.4 6.0 15 5.8 1.7 2.9 2 1 1 3 3 2 0 Bacterial protein of unknown function (DUF948) Ldl_recept_a PF00057.16 001032907.1_29626001_1 - 2.2e-101 331.7 160.0 8.9e-15 54.5 12.7 8.9 9 0 0 9 9 9 8 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.15 001032907.1_29626001_1 - 8.9e-67 221.2 9.7 2.8e-16 59.6 0.1 5.4 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 001032907.1_29626001_1 - 3e-17 62.5 35.8 5.6e-09 36.0 4.6 6.1 5 1 0 5 5 5 3 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 001032907.1_29626001_1 - 7.9e-08 32.2 6.0 7.9e-08 32.2 6.0 11.1 5 2 3 9 9 9 3 Calcium-binding EGF domain cEGF PF12662.5 001032907.1_29626001_1 - 2e-06 27.5 39.4 9.8e-05 22.1 2.1 6.2 6 0 0 6 6 6 3 Complement Clr-like EGF-like SGL PF08450.10 001032907.1_29626001_1 - 0.00012 21.6 0.7 0.34 10.3 0.3 2.7 1 1 1 2 2 2 2 SMP-30/Gluconolaconase/LRE-like region EGF PF00008.25 001032907.1_29626001_1 - 0.001 19.2 18.3 0.0015 18.7 2.6 9.6 8 2 1 9 9 9 3 EGF-like domain DUF4010 PF13194.4 001032907.1_29626001_1 - 0.15 11.6 0.1 0.27 10.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4010) Glyco_hydro_18 PF00704.26 001285689.1_09023001_2 - 3.2e-90 302.9 0.0 3.7e-90 302.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 EPO_TPO PF00758.16 001082090.1_37922001_1 - 2.8e-66 222.3 0.0 3.3e-66 222.1 0.0 1.0 1 0 0 1 1 1 1 Erythropoietin/thrombopoietin Axin_b-cat_bind PF08833.8 001082090.1_37922001_2 - 1.2 9.2 6.0 4.7 7.3 6.0 2.0 1 0 0 1 1 1 0 Axin beta-catenin binding domain GRIP PF01465.18 001082090.1_37922001_3 - 0.00043 20.0 0.0 0.00067 19.4 0.0 1.3 1 0 0 1 1 1 1 GRIP domain Lipocalin PF00061.21 001009300.1_22422001_1 - 1.4e-38 132.2 0.0 1.7e-38 131.9 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Triabin PF03973.11 001009300.1_22422001_1 - 0.013 15.2 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 Triabin Calc_CGRP_IAPP PF00214.17 214107.1_49823001_1 - 4.6e-27 94.6 0.0 7.4e-27 94.0 0.0 1.3 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family Defensin_beta_2 PF13841.4 001129766.1_39721001_1 - 3.7e-09 36.8 11.9 5e-09 36.3 11.9 1.2 1 0 0 1 1 1 1 Beta defensin Cys_knot PF00007.20 214368.2_49822001_1 - 2.7e-34 117.5 14.2 3.5e-34 117.1 14.2 1.1 1 0 0 1 1 1 1 Cystine-knot domain Hormone_1 PF00103.18 001009315.3_39522001_1 - 4.5e-46 157.2 0.0 5.1e-46 157.0 0.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family XTBD PF11952.6 001009315.3_39522001_1 - 0.061 13.0 0.0 0.23 11.1 0.0 2.0 2 1 0 2 2 2 0 XRN-Two Binding Domain, XTBD Phospholip_A2_1 PF00068.17 001310574.1_31322001_3 - 4.9e-34 117.0 10.7 6.7e-34 116.5 10.7 1.2 1 0 0 1 1 1 1 Phospholipase A2 Phospholip_A2_2 PF05826.10 001310574.1_31322001_3 - 0.051 13.6 14.2 2.2 8.4 14.2 2.3 1 1 0 1 1 1 0 Phospholipase A2 SMI1_KNR4 PF09346.8 001131960.1_43524001_3 - 0.0074 16.6 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) Neurexophilin PF06312.10 021680.2_45724001_2 - 2.2e-63 213.4 6.1 9.2e-35 119.9 2.6 2.5 3 0 0 3 3 3 2 Neurexophilin TSGP1 PF07771.9 021680.2_45724001_2 - 5.6 7.0 12.4 8.7 6.4 12.4 1.3 1 0 0 1 1 1 0 Tick salivary peptide group 1 ETRAMP PF09716.8 021680.2_45724001_2 - 9.1 6.3 12.9 25 4.9 12.6 1.7 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Zona_pellucida PF00100.21 214272.1_49826001_1 - 3.9e-42 144.6 0.0 6.9e-42 143.8 0.0 1.4 1 0 0 1 1 1 1 Zona pellucida-like domain Trypsin PF00089.24 001005382.2_45722001_1 - 5.3e-69 232.3 0.0 6.2e-69 232.0 0.0 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001005382.2_45722001_1 - 1.4e-06 29.1 0.0 2.1e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001005382.2_45722001_1 - 0.00021 21.5 0.1 0.017 15.4 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1986) CD4-extracel PF09191.8 001009250.1_22427001_2 - 5.1e-47 158.6 0.4 5.1e-47 158.6 0.4 2.7 3 1 0 3 3 3 1 CD4, extracellular C2-set PF05790.13 001009250.1_22427001_2 - 3.8e-40 135.8 15.8 4.2e-20 71.6 3.8 3.7 3 1 0 3 3 3 2 Immunoglobulin C2-set domain ig PF00047.23 001009250.1_22427001_2 - 1e-20 73.5 7.9 2.9e-15 56.1 0.1 4.1 3 1 1 4 4 4 2 Immunoglobulin domain Ig_3 PF13927.4 001009250.1_22427001_2 - 3.3e-14 53.1 5.9 2.8e-07 30.9 0.0 4.0 4 0 0 4 4 4 2 Immunoglobulin domain V-set PF07686.15 001009250.1_22427001_2 - 8.7e-14 51.5 1.7 5.7e-10 39.2 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin V-set domain Tcell_CD4_C PF12104.6 001009250.1_22427001_2 - 4.3e-13 48.8 9.0 4.3e-13 48.8 9.0 1.9 2 0 0 2 2 1 1 T cell CD4 receptor C terminal region Ig_2 PF13895.4 001009250.1_22427001_2 - 4.9e-12 45.9 3.8 0.00055 20.1 0.0 4.1 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 001009250.1_22427001_2 - 9.8e-11 41.4 1.3 2.1e-06 27.6 0.0 4.2 4 1 0 4 4 4 2 Immunoglobulin I-set domain Receptor_2B4 PF11465.6 001009250.1_22427001_2 - 0.00067 19.7 0.4 0.004 17.2 0.0 2.3 2 0 0 2 2 2 1 Natural killer cell receptor 2B4 Ig_5 PF16681.3 001009250.1_22427001_2 - 0.0019 18.4 0.8 0.83 10.0 0.0 3.4 3 1 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Herpes_gE PF02480.14 001009250.1_22427001_2 - 0.0043 15.7 0.7 0.4 9.2 0.4 2.3 2 0 0 2 2 2 2 Alphaherpesvirus glycoprotein E Izumo-Ig PF16706.3 001009250.1_22427001_2 - 0.9 9.5 5.3 9.3 6.2 0.0 3.7 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain Prothymosin PF03247.12 001132923.1_43523001_1 - 2.7e-35 121.0 51.1 2.7e-35 121.0 51.1 2.2 2 0 0 2 2 2 1 Prothymosin/parathymosin family LSR PF05624.12 001132923.1_43523001_1 - 0.026 14.4 0.8 0.058 13.3 0.8 1.6 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) TLV_coat PF00429.17 001305590.1_01323001_1 - 4.3e-09 35.5 8.3 8.9e-08 31.1 8.2 2.7 1 1 0 1 1 1 1 ENV polyprotein (coat polyprotein) GP41 PF00517.15 001305590.1_01323001_1 - 0.049 13.3 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 Retroviral envelope protein Corona_S2 PF01601.14 001305590.1_01323001_1 - 0.85 7.9 7.1 1.4 7.2 7.1 1.3 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein PilX_N PF14341.4 001305590.1_01323001_1 - 5.7 6.8 5.4 1.2 9.0 0.3 2.1 2 0 0 2 2 2 0 PilX N-terminal TGFb_propeptide PF00688.16 001195723.1_37923001_1 - 1.1e-53 182.4 0.2 1.6e-53 181.9 0.2 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001195723.1_37923001_1 - 9.5e-34 116.3 0.5 1.8e-33 115.4 0.5 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain Tnp_DNA_bind PF14706.4 001195723.1_37923001_1 - 0.018 14.7 0.1 2.4 7.9 0.0 2.7 2 0 0 2 2 2 0 Transposase DNA-binding Ig_3 PF13927.4 213891.1_49825001_2 - 2.1e-45 153.1 6.6 3.9e-12 46.5 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 213891.1_49825001_2 - 4e-40 135.8 4.7 3.2e-12 46.3 0.0 4.7 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 213891.1_49825001_2 - 3.6e-38 129.4 0.7 2e-10 40.5 0.0 5.1 4 2 0 4 4 4 4 Immunoglobulin I-set domain Ig_2 PF13895.4 213891.1_49825001_2 - 8.3e-36 122.1 1.4 1.2e-09 38.2 0.0 5.3 5 0 0 5 5 5 4 Immunoglobulin domain C2-set PF05790.13 213891.1_49825001_2 - 1.3e-27 95.7 5.1 5.4e-24 84.1 0.2 4.4 5 0 0 5 5 4 2 Immunoglobulin C2-set domain V-set PF07686.15 213891.1_49825001_2 - 7.6e-20 71.0 10.8 0.0013 18.7 0.0 8.5 5 4 3 8 8 8 4 Immunoglobulin V-set domain C2-set_2 PF08205.10 213891.1_49825001_2 - 5.5e-12 45.5 3.3 0.0023 17.8 0.1 4.8 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 213891.1_49825001_2 - 1.1e-09 38.5 0.3 0.0036 17.6 0.0 4.2 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 213891.1_49825001_2 - 7.6e-08 32.5 0.0 0.17 12.1 0.0 3.7 3 0 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 213891.1_49825001_2 - 1.8e-07 31.0 0.0 0.21 11.5 0.0 4.4 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain C1-set PF07654.13 213891.1_49825001_2 - 2.7e-06 27.6 3.3 0.029 14.7 0.0 5.5 5 1 0 5 5 5 1 Immunoglobulin C1-set domain ICAM_N PF03921.12 213891.1_49825001_2 - 3.5e-06 26.5 1.7 0.0028 17.2 0.3 3.5 3 0 0 3 3 3 1 Intercellular adhesion molecule (ICAM), N-terminal domain Receptor_2B4 PF11465.6 213891.1_49825001_2 - 0.0022 18.0 0.0 0.97 9.5 0.0 3.3 3 0 0 3 3 3 1 Natural killer cell receptor 2B4 DUF4701 PF15773.3 073370.2_32926120_1 - 1.5e-107 360.6 27.0 1.9e-107 360.3 27.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4701) DUF4701 PF15773.3 073370.2_32926120_2 - 1.7e-66 225.2 5.6 2.4e-66 224.6 5.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4701) Ig_2 PF13895.4 135215.1_26226120_2 - 4e-53 177.6 1.5 1.8e-08 34.4 0.0 6.3 6 0 0 6 6 6 6 Immunoglobulin domain Ig_3 PF13927.4 135215.1_26226120_2 - 5.2e-43 145.4 0.3 1.2e-08 35.4 0.0 6.6 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 135215.1_26226120_2 - 1.4e-27 95.5 3.2 2e-09 37.4 0.0 6.5 6 0 0 6 6 6 5 Immunoglobulin domain I-set PF07679.14 135215.1_26226120_2 - 4.6e-15 55.3 0.0 0.00024 21.0 0.0 6.5 6 0 0 6 6 6 4 Immunoglobulin I-set domain V-set PF07686.15 135215.1_26226120_2 - 5.6e-11 42.4 5.4 0.22 11.5 0.0 7.7 7 2 1 8 8 8 3 Immunoglobulin V-set domain Ig_4 PF16680.3 135215.1_26226120_2 - 1.5e-06 28.3 1.8 2.3 8.5 0.4 5.9 6 0 0 6 6 6 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 135215.1_26226120_2 - 1e-05 25.4 0.0 2.3 8.2 0.0 5.3 6 0 0 6 6 6 2 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.9 135215.1_26226120_2 - 0.00011 22.1 0.3 0.46 10.3 0.0 3.7 4 0 0 4 4 4 2 CD47 immunoglobulin-like domain C2-set_2 PF08205.10 135215.1_26226120_2 - 0.00057 19.8 0.4 0.037 13.9 0.0 3.7 5 0 0 5 5 5 1 CD80-like C2-set immunoglobulin domain Kazal_1 PF00050.19 073417.1_26222120_3 - 2e-18 66.0 3.9 3e-18 65.4 3.9 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 073417.1_26222120_3 - 1.5e-09 37.7 1.6 2.4e-09 37.1 1.6 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Ribosomal_S27e PF01667.15 154464.1_32922120_3 - 2.1e-27 94.5 2.8 3.1e-27 93.9 2.8 1.3 1 0 0 1 1 1 1 Ribosomal protein S27 DUF4564 PF15169.4 036518.1_26224120_1 - 3.8e-44 150.5 0.0 5.3e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4564) Neugrin PF06413.9 028055.1_45724120_2 - 4.6e-88 294.9 0.6 5.8e-88 294.5 0.6 1.1 1 0 0 1 1 1 1 Neugrin MRP-L20 PF12824.5 028055.1_45724120_2 - 0.0025 17.9 1.8 0.0039 17.2 0.2 2.0 2 0 0 2 2 2 1 Mitochondrial ribosomal protein subunit L20 AAR2 PF05282.9 028055.1_45724120_2 - 0.2 10.9 1.4 12 5.0 0.0 2.5 2 1 1 3 3 3 0 AAR2 protein UPAR_LY6_2 PF16975.3 033304.2_32928120_3 - 8.8e-52 173.6 11.7 1.6e-51 172.8 11.7 1.4 1 0 0 1 1 1 1 Ly6/PLAUR domain-containing protein 6, Lypd6 V-set PF07686.15 145981.2_49824120_3 - 1.6e-16 60.3 0.0 3.2e-16 59.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 145981.2_49824120_3 - 1e-09 38.7 0.0 3.3e-09 37.1 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 145981.2_49824120_3 - 7.4e-06 25.9 0.0 1.9e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 145981.2_49824120_3 - 7.6e-06 25.8 0.0 3.1e-05 23.8 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 145981.2_49824120_3 - 0.014 15.6 0.2 0.2 11.9 0.2 2.4 1 1 0 1 1 1 0 Immunoglobulin domain HRM PF02793.20 073147.1_45724120_2 - 1.2e-15 57.4 6.4 3e-15 56.1 6.4 1.8 1 0 0 1 1 1 1 Hormone receptor domain 7tm_2 PF00002.22 073147.1_45724120_3 - 2e-70 236.7 13.7 2.7e-70 236.3 13.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.9 073147.1_45724120_3 - 0.04 12.9 9.0 0.055 12.5 9.0 1.1 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor Serpin PF00079.18 214058.2_49823001_3 - 8.8e-107 357.5 2.3 1e-106 357.3 2.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) UPF0730 PF15827.3 154549.1_32922120_1 - 0.049 13.7 0.1 0.088 12.9 0.1 1.4 1 0 0 1 1 1 0 UPF0730 unknown protein family Cadherin PF00028.15 001031620.3_39729001_2 - 3.9e-79 261.1 0.0 3.4e-16 59.3 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001031620.3_39729001_2 - 4.7e-38 128.7 0.0 3.9e-32 109.8 0.0 4.8 6 1 1 7 7 7 2 Cadherin-like Cadherin_tail PF15974.3 001031620.3_39729001_2 - 2.4e-25 89.3 3.3 4.8e-25 88.3 3.3 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001031620.3_39729001_2 - 2.7e-23 82.4 0.4 6.1e-23 81.3 0.4 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001031620.3_39729001_2 - 8e-05 22.5 3.1 0.084 12.8 0.1 4.3 4 0 0 4 4 4 1 Cadherin-like FYVE_2 PF02318.14 153959.1_32926120_2 - 2.1e-09 37.5 5.7 4e-09 36.6 5.7 1.4 1 0 0 1 1 1 1 FYVE-type zinc finger Glyco_transf_29 PF00777.16 001037301.1_39723001_1 - 8.5e-76 254.7 0.0 1.3e-75 254.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) RhoGAP PF00620.25 031305.2_26229001_2 - 7.6e-49 165.3 0.0 1.4e-48 164.4 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain DUF3435 PF11917.6 031305.2_26229001_2 - 0.061 12.1 4.4 0.1 11.4 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) FPP PF05911.9 031305.2_26229001_2 - 0.15 10.2 15.1 0.02 13.1 7.0 2.0 2 0 0 2 2 2 0 Filament-like plant protein, long coiled-coil CALCOCO1 PF07888.9 031305.2_26229001_2 - 1.6 7.0 11.2 0.24 9.8 7.3 1.4 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DMPK_coil PF08826.8 031305.2_26229001_2 - 2 8.5 14.7 2.4 8.2 4.4 2.7 1 1 1 2 2 2 0 DMPK coiled coil domain like Mod_r PF07200.11 031305.2_26229001_2 - 2.1 8.3 12.3 0.74 9.8 7.1 2.3 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein ATG16 PF08614.9 031305.2_26229001_2 - 6.8 6.7 19.9 0.011 15.9 8.8 1.8 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) bZIP_1 PF00170.19 031305.2_26229001_2 - 6.8 6.7 10.6 1.4 8.9 2.3 3.4 3 1 1 4 4 4 0 bZIP transcription factor IncA PF04156.12 031305.2_26229001_2 - 7.4 6.2 10.6 40 3.8 10.7 2.1 1 1 0 1 1 1 0 IncA protein Glyco_transf_29 PF00777.16 001037309.1_39722001_1 - 1.2e-58 198.5 0.0 1.6e-58 198.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) XK-related PF09815.7 001033037.1_39725001_1 - 4.1e-89 298.7 22.6 4.9e-89 298.5 22.6 1.1 1 0 0 1 1 1 1 XK-related protein Histone PF00125.22 022647.1_45721001_1 - 3.8e-21 75.7 0.4 4.8e-21 75.4 0.4 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 022647.1_45721001_1 - 0.0089 16.2 0.3 0.022 14.9 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone EGF PF00008.25 001128466.1_49823001_1 - 3.7e-22 78.1 102.1 1.4e-08 34.7 2.9 7.4 8 0 0 8 8 8 6 EGF-like domain hEGF PF12661.5 001128466.1_49823001_1 - 2.8e-17 62.6 90.0 8.7e-06 26.1 2.4 8.3 8 0 0 8 8 8 6 Human growth factor-like EGF EGF_2 PF07974.11 001128466.1_49823001_1 - 1.3e-07 31.7 106.2 0.0094 16.2 11.0 7.2 7 0 0 7 7 7 5 EGF-like domain EGF_CA PF07645.13 001128466.1_49823001_1 - 0.005 16.9 75.0 0.031 14.3 4.2 6.7 2 1 4 6 6 6 4 Calcium-binding EGF domain Laminin_EGF PF00053.22 001128466.1_49823001_1 - 2 8.5 90.2 0.13 12.3 14.6 7.0 2 1 5 7 7 7 0 Laminin EGF domain Arrestin_N PF00339.27 001131752.1_43524001_1 - 7.1e-43 146.0 0.0 2.6e-39 134.5 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 001131752.1_43524001_1 - 1.8e-27 96.3 0.3 3e-27 95.5 0.3 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Amelin PF05111.10 214037.1_49824001_2 - 1.8e-222 738.8 26.1 2.1e-222 738.6 26.1 1.0 1 0 0 1 1 1 1 Ameloblastin precursor (Amelin) Aldedh PF00171.20 001009778.1_39525001_3 - 9.9e-184 611.0 0.0 1.1e-183 610.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.12 001009778.1_39525001_3 - 0.013 14.4 0.0 0.023 13.6 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) DUF1487 PF07368.9 001009778.1_39525001_3 - 0.1 11.9 0.0 0.3 10.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Casein PF00363.16 001009363.1_39523001_3 - 2.3e-26 92.1 17.0 2.7e-21 75.9 5.4 2.6 3 0 0 3 3 3 2 Casein DUF1980 PF09323.8 001009363.1_39523001_3 - 0.061 13.1 6.9 0.057 13.2 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) NusB PF01029.16 001009363.1_39523001_3 - 0.087 12.9 0.9 0.29 11.2 0.1 2.0 2 0 0 2 2 2 0 NusB family EST1 PF10374.7 001009363.1_39523001_3 - 0.13 12.8 7.2 0.071 13.6 2.3 2.2 1 1 1 2 2 2 0 Telomerase activating protein Est1 Glyco_transf_29 PF00777.16 001037302.1_39723001_1 - 2.7e-76 256.4 0.0 3.3e-76 256.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) SNAPc_SNAP43 PF09808.7 178392.4_32925001_3 - 6e-61 205.6 8.0 8.4e-61 205.1 8.0 1.2 1 0 0 1 1 1 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 Amino_oxidase PF01593.22 001081832.1_21024001_1 - 1.1e-76 258.8 0.0 1.3e-76 258.6 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 001081832.1_21024001_1 - 6.9e-14 51.7 0.2 2e-13 50.3 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001081832.1_21024001_1 - 2.9e-08 33.6 0.0 5.4e-08 32.7 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 001081832.1_21024001_1 - 4.7e-06 25.8 0.6 6.7e-06 25.3 0.6 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.15 001081832.1_21024001_1 - 1.3e-05 24.4 0.1 2.3e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.12 001081832.1_21024001_1 - 1.9e-05 23.4 0.1 0.00019 20.1 0.1 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.12 001081832.1_21024001_1 - 2e-05 23.8 0.1 8.1e-05 21.9 0.1 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.5 001081832.1_21024001_1 - 3.7e-05 23.1 0.3 5.5e-05 22.6 0.3 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.25 001081832.1_21024001_1 - 0.00015 22.1 1.2 0.00025 21.4 0.4 1.8 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.17 001081832.1_21024001_1 - 0.00056 19.1 0.1 0.001 18.3 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.4 001081832.1_21024001_1 - 0.0021 17.2 0.1 0.49 9.5 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.19 001081832.1_21024001_1 - 0.0028 16.8 0.1 0.0046 16.1 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.10 001081832.1_21024001_1 - 0.013 14.5 0.1 0.02 13.8 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein GIDA PF01134.20 001081832.1_21024001_1 - 0.016 14.2 1.2 0.035 13.0 0.1 2.0 3 0 0 3 3 3 0 Glucose inhibited division protein A NAD_binding_9 PF13454.4 001081832.1_21024001_1 - 0.045 13.6 0.2 0.14 12.0 0.1 1.8 2 0 0 2 2 2 0 FAD-NAD(P)-binding TrkA_N PF02254.16 001081832.1_21024001_1 - 0.075 13.2 0.5 1.1 9.3 0.2 2.3 2 0 0 2 2 2 0 TrkA-N domain MCRA PF06100.9 001081832.1_21024001_1 - 0.09 11.4 0.0 0.17 10.5 0.0 1.3 1 0 0 1 1 1 0 MCRA family Trp_halogenase PF04820.12 001081832.1_21024001_1 - 0.29 9.8 1.1 0.27 9.9 0.1 1.4 2 0 0 2 2 2 0 Tryptophan halogenase Ras PF00071.20 001133109.1_43527001_1 - 9.9e-62 207.2 0.1 1.3e-61 206.8 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001133109.1_43527001_1 - 7.2e-32 110.0 0.0 1.2e-31 109.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001133109.1_43527001_1 - 6.7e-12 45.1 0.0 1e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001133109.1_43527001_1 - 0.00088 19.2 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001133109.1_43527001_1 - 0.0045 16.2 0.0 0.0065 15.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001133109.1_43527001_1 - 0.0097 15.3 0.0 0.027 13.9 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001133109.1_43527001_1 - 0.033 14.0 0.0 2.2 8.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DUF1467 PF07330.10 001133109.1_43527001_3 - 0.76 9.6 3.4 1.3 8.8 3.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1467) Histone_H2A_C PF16211.3 021840.2_45724001_3 - 1.1e-19 69.7 1.2 1.1e-19 69.7 1.2 2.2 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.22 021840.2_45724001_3 - 3.4e-16 59.7 0.0 6e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 021840.2_45724001_3 - 0.00098 19.2 0.0 0.0015 18.6 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAS2R PF05296.11 001009129.1_39722001_1 - 2e-71 240.4 24.7 2.5e-71 240.1 24.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Ig_4 PF16680.3 001008686.1_49822001_2 - 7.4e-29 99.8 1.2 1.9e-28 98.5 1.2 1.7 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.3 001008686.1_49822001_2 - 3.9e-09 36.7 1.2 9.5e-09 35.4 1.2 1.6 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain ITAM PF02189.13 001008686.1_49822001_2 - 4.1e-08 33.1 3.4 8.4e-08 32.1 3.4 1.6 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif Ig_3 PF13927.4 001008686.1_49822001_2 - 0.00027 21.4 0.2 0.00066 20.1 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Pkinase_Tyr PF07714.15 001045502.1_39726001_1 - 2.7e-84 282.4 0.0 3.4e-84 282.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001045502.1_39726001_1 - 3.3e-38 131.4 0.0 5.8e-37 127.4 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.23 001045502.1_39726001_1 - 1.8e-21 76.4 0.0 2.8e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Lamprin PF06403.9 001045502.1_39726001_1 - 0.021 14.7 0.4 0.049 13.5 0.4 1.6 1 0 0 1 1 1 0 Lamprin Kinase-like PF14531.4 001045502.1_39726001_1 - 0.049 12.8 0.0 0.071 12.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like RRM_1 PF00076.20 001109911.1_45725001_1 - 9.1e-53 175.9 0.1 6.7e-19 67.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M PF11532.6 001109911.1_45725001_1 - 5.8e-19 67.9 10.4 5.8e-19 67.9 10.4 2.3 2 0 0 2 2 2 1 Heterogeneous nuclear ribonucleoprotein M Limkain-b1 PF11608.6 001109911.1_45725001_1 - 0.00011 22.1 0.2 0.0098 15.8 0.0 2.6 2 1 0 2 2 2 1 Limkain b1 Collagen_mid PF15984.3 001109911.1_45725001_1 - 0.0002 21.1 0.0 0.0002 21.1 0.0 2.7 2 1 1 3 3 3 1 Bacterial collagen, middle region RRM_5 PF13893.4 001109911.1_45725001_1 - 0.00021 20.7 0.0 0.25 10.8 0.0 3.2 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001109911.1_45725001_1 - 0.0022 17.7 0.0 0.13 12.0 0.0 2.4 2 0 0 2 2 2 1 Occluded RNA-recognition motif S_100 PF01023.17 199422.1_32922001_3 - 5.2e-12 45.1 0.2 1.4e-11 43.8 0.1 1.8 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.30 199422.1_32922001_3 - 2.9e-06 26.3 0.7 1.8e-05 23.8 0.1 2.1 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 199422.1_32922001_3 - 1.5e-05 24.4 0.4 0.0011 18.6 0.2 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.4 199422.1_32922001_3 - 3.2e-05 23.1 1.0 0.00043 19.5 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.4 199422.1_32922001_3 - 0.00049 20.4 0.3 0.0012 19.1 0.3 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.4 199422.1_32922001_3 - 0.013 15.1 0.1 0.035 13.8 0.1 1.7 1 1 0 1 1 1 0 EF-hand domain pair 7tm_1 PF00001.19 001009325.2_22425001_2 - 1.7e-57 194.5 11.2 2.4e-57 194.1 11.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009325.2_22425001_2 - 3.2e-12 46.2 8.2 5.9e-12 45.4 8.2 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001009325.2_22425001_2 - 1.2e-07 31.2 7.8 2.2e-07 30.4 7.8 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001009325.2_22425001_2 - 0.00085 19.0 6.0 0.00085 19.0 6.0 2.5 2 1 0 2 2 2 1 Olfactory receptor Git3 PF11710.6 001009325.2_22425001_2 - 1.8 8.2 19.5 0.027 14.1 12.4 1.5 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 Calsequestrin PF01216.15 001082268.1_37924001_3 - 1.6e-235 781.1 24.8 2e-235 780.8 24.8 1.0 1 0 0 1 1 1 1 Calsequestrin Thioredoxin_6 PF13848.4 001082268.1_37924001_3 - 2.1e-24 86.4 11.1 6.6e-20 71.7 3.5 2.9 2 1 1 3 3 3 2 Thioredoxin-like domain WGG PF10273.7 001082268.1_37924001_3 - 0.52 10.9 5.1 0.55 10.8 1.6 2.3 2 0 0 2 2 2 0 Pre-rRNA-processing protein TSR2 CBM_21 PF03370.11 001082303.1_37928001_1 - 1.9e-30 105.2 0.1 4e-30 104.1 0.1 1.5 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.3 001082303.1_37928001_1 - 7.2e-10 39.2 0.1 2e-09 37.7 0.1 1.8 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) DUF3287 PF11690.6 001082303.1_37928001_1 - 0.11 12.1 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) GTP_EFTU PF00009.25 001009326.1_22424001_3 - 2.7e-54 183.5 0.0 3.8e-54 183.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 001009326.1_22424001_3 - 9.2e-40 135.3 0.0 2e-39 134.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.23 001009326.1_22424001_3 - 7.6e-15 54.9 2.2 8.4e-15 54.8 0.7 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 001009326.1_22424001_3 - 0.00041 20.3 0.2 0.0097 15.9 0.2 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.4 001009326.1_22424001_3 - 0.01 15.7 1.7 0.017 15.0 0.3 2.1 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Dynamin_N PF00350.21 001009326.1_22424001_3 - 0.12 12.3 0.1 20 5.1 0.1 2.4 2 0 0 2 2 2 0 Dynamin family Pyridoxal_deC PF00282.17 001034113.1_39724001_1 - 2.8e-151 503.3 0.0 3.4e-151 503.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 001034113.1_39724001_1 - 7.5e-06 25.0 0.0 7.7e-05 21.7 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.19 001034113.1_39724001_1 - 0.00015 21.1 0.0 0.00034 19.8 0.0 1.6 2 0 0 2 2 2 1 Beta-eliminating lyase SepSecS PF05889.11 001034113.1_39724001_1 - 0.021 13.4 0.0 0.032 12.8 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS DegT_DnrJ_EryC1 PF01041.15 001034113.1_39724001_1 - 0.034 13.3 0.0 0.048 12.8 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family OKR_DC_1 PF01276.18 001034113.1_39724001_1 - 0.039 12.5 0.0 0.064 11.9 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain RAG1 PF12940.5 001123184.1_49827001_1 - 0 1261.5 1.6 0 1261.1 0.7 1.5 2 0 0 2 2 2 1 Recombination-activation protein 1 (RAG1), recombinase RAG1_imp_bd PF12560.6 001123184.1_49827001_1 - 1.2e-120 402.2 11.9 3e-120 401.0 11.9 1.7 1 0 0 1 1 1 1 RAG1 importin binding zf-RAG1 PF10426.7 001123184.1_49827001_1 - 6.6e-19 67.6 11.2 1.2e-17 63.6 4.4 2.6 2 0 0 2 2 2 2 Recombination-activating protein 1 zinc-finger domain zf-C3HC4_2 PF13923.4 001123184.1_49827001_1 - 3.9e-07 29.7 13.2 3.9e-07 29.7 13.2 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001123184.1_49827001_1 - 6.3e-06 25.8 14.1 6.3e-06 25.8 14.1 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 001123184.1_49827001_1 - 0.0001 22.0 8.6 0.0001 22.0 8.6 2.0 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.3 001123184.1_49827001_1 - 0.0017 18.3 12.4 0.0038 17.2 10.7 2.6 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-RING_UBOX PF13445.4 001123184.1_49827001_1 - 0.0034 17.2 10.4 0.0034 17.2 10.4 2.6 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001123184.1_49827001_1 - 0.0039 17.2 13.4 0.0039 17.2 13.4 3.1 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING Ribosomal_L32p PF01783.21 001123184.1_49827001_1 - 2.9 8.1 7.2 0.3 11.2 1.0 2.7 2 0 0 2 2 2 0 Ribosomal L32p protein family zf-RING_UBOX PF13445.4 001012650.1_39723001_1 - 7.9e-12 44.9 4.0 7.9e-12 44.9 4.0 2.7 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001012650.1_39723001_1 - 5.2e-11 42.4 8.5 5.2e-11 42.4 8.5 2.0 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING SPRY PF00622.26 001012650.1_39723001_1 - 2.6e-10 40.3 0.1 5.3e-10 39.3 0.1 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4 PF00097.23 001012650.1_39723001_1 - 2.5e-09 36.7 8.3 8.5e-09 35.0 8.3 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001012650.1_39723001_1 - 6.1e-08 32.2 9.2 2.1e-07 30.5 9.2 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001012650.1_39723001_1 - 9.3e-08 32.1 7.6 9.3e-08 32.1 7.6 2.1 2 0 0 2 2 1 1 Ring finger domain zf-B_box PF00643.22 001012650.1_39723001_1 - 2.6e-07 30.6 6.2 2.6e-07 30.6 6.2 3.0 3 1 0 3 3 2 2 B-box zinc finger zf-C3HC4_3 PF13920.4 001012650.1_39723001_1 - 3.3e-07 29.9 5.6 3.3e-07 29.9 5.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001012650.1_39723001_1 - 1.3e-06 28.1 6.8 1.3e-06 28.1 6.8 2.1 2 0 0 2 2 1 1 zinc-RING finger domain TMF_TATA_bd PF12325.6 001012650.1_39723001_1 - 3.4e-06 27.1 1.7 3.4e-06 27.1 1.7 2.3 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding U-box PF04564.13 001012650.1_39723001_1 - 0.0027 17.7 0.0 0.0059 16.6 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-RING_10 PF16685.3 001012650.1_39723001_1 - 0.0096 15.9 5.8 0.0096 15.9 5.8 2.3 1 1 1 2 2 2 1 zinc RING finger of MSL2 BssS PF13991.4 001012650.1_39723001_1 - 0.042 13.8 1.6 0.89 9.5 0.4 2.9 2 0 0 2 2 2 0 BssS protein family zf-RING_4 PF14570.4 001012650.1_39723001_1 - 0.053 13.1 6.3 0.51 10.0 6.6 2.5 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.6 001012650.1_39723001_1 - 0.085 12.6 4.1 0.3 10.8 4.1 1.9 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit AAA_11 PF13086.4 001012650.1_39723001_1 - 0.18 11.4 4.3 0.27 10.8 4.3 1.2 1 0 0 1 1 1 0 AAA domain Baculo_IE-1 PF05290.9 001012650.1_39723001_1 - 0.24 11.2 3.5 0.28 11.0 1.2 2.3 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) FAM76 PF16046.3 001012650.1_39723001_1 - 0.35 10.0 14.5 0.0076 15.5 7.1 1.8 2 0 0 2 2 2 0 FAM76 protein Prok-RING_4 PF14447.4 001012650.1_39723001_1 - 0.38 10.5 16.1 0.28 10.9 11.4 3.0 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.4 001012650.1_39723001_1 - 0.77 9.5 7.2 0.22 11.3 3.5 2.1 2 1 0 2 2 2 0 zf-RING of BARD1-type protein CENP-Q PF13094.4 001012650.1_39723001_1 - 1.5 8.8 13.8 2.4 8.2 13.8 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit E1_dh PF00676.18 001110813.1_39724001_2 - 4.5e-123 409.8 0.0 5.8e-123 409.5 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.4 001110813.1_39724001_2 - 0.00071 18.7 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.19 001110813.1_39724001_2 - 0.0086 15.7 0.5 0.018 14.7 0.3 1.6 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain GTP_EFTU PF00009.25 001009165.1_39724001_1 - 2.9e-54 183.4 0.0 4.1e-54 183.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 001009165.1_39724001_1 - 9.8e-40 135.2 0.0 2.1e-39 134.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.23 001009165.1_39724001_1 - 8.7e-15 54.7 0.7 8.7e-15 54.7 0.7 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 001009165.1_39724001_1 - 0.00047 20.1 0.2 0.01 15.8 0.2 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.4 001009165.1_39724001_1 - 0.0084 15.9 1.9 0.017 14.9 0.3 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 4 G-alpha PF00503.18 001009165.1_39724001_1 - 0.12 11.4 0.2 0.3 10.0 0.1 1.7 2 0 0 2 2 2 0 G-protein alpha subunit Dynamin_N PF00350.21 001009165.1_39724001_1 - 0.12 12.3 0.1 20 5.0 0.1 2.5 2 0 0 2 2 2 0 Dynamin family Transthyretin PF00576.19 214212.1_49822001_1 - 3.4e-18 66.2 0.0 4.5e-18 65.8 0.0 1.1 1 0 0 1 1 1 1 HIUase/Transthyretin family Ribosomal_S25 PF03297.13 001009457.1_39521001_1 - 7.8e-50 167.2 8.0 1.4e-49 166.3 8.0 1.5 1 0 0 1 1 1 1 S25 ribosomal protein Fe_dep_repress PF01325.17 001009457.1_39521001_1 - 0.09 12.9 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain TrmB PF01978.17 001009457.1_39521001_1 - 0.092 12.5 0.3 0.19 11.5 0.2 1.6 1 1 1 2 2 2 0 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.5 001009457.1_39521001_1 - 0.12 12.2 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.4 001009457.1_39521001_1 - 0.12 11.8 0.2 0.25 10.8 0.2 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Casein_kappa PF00997.16 001004026.1_49822001_1 - 8.9e-73 243.5 17.6 1.9e-72 242.5 17.6 1.5 1 1 0 1 1 1 1 Kappa casein Glyco_transf_29 PF00777.16 001009087.1_39723001_1 - 3e-77 259.5 0.0 3.9e-77 259.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Homeobox PF00046.27 054068.2_32928001_1 - 7.9e-23 79.9 1.4 1.2e-22 79.3 1.4 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 054068.2_32928001_1 - 0.012 15.4 0.1 0.023 14.4 0.1 1.4 1 0 0 1 1 1 0 Homeobox KN domain DUF4604 PF15377.4 001133538.1_43522001_1 - 1.1e-05 25.9 5.0 1.2e-05 25.7 5.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Med19 PF10278.7 001133538.1_43522001_1 - 8.2 6.2 25.3 11 5.8 25.3 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF4604 PF15377.4 001133538.1_43522001_2 - 0.002 18.5 9.8 0.0023 18.3 9.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Coilin_N PF15862.3 001133538.1_43522001_3 - 0.00022 20.9 4.7 0.00028 20.6 4.7 1.2 1 0 0 1 1 1 1 Coilin N-terminus SR-25 PF10500.7 001133538.1_43522001_3 - 4.2 6.8 33.4 5.7 6.3 33.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Defensin_propep PF00879.16 001141940.1_40422001_2 - 3.9e-21 75.0 5.2 5.8e-21 74.4 5.2 1.3 1 0 0 1 1 1 1 Defensin propeptide OAD_gamma PF04277.11 001141940.1_40422001_2 - 1.1 9.7 4.0 7.6 7.1 1.5 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain LCAT PF02450.13 001112613.1_40423001_1 - 4.9e-117 391.3 0.0 2.6e-116 388.9 0.0 1.8 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.5 001112613.1_40423001_1 - 0.00014 22.4 1.7 0.00019 22.0 0.9 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 001112613.1_40423001_1 - 0.0032 16.7 0.0 0.0057 15.8 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.11 001112613.1_40423001_1 - 0.023 14.4 0.0 0.044 13.5 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Abhydrolase_1 PF00561.18 001112613.1_40423001_1 - 0.13 11.7 0.1 0.27 10.7 0.0 1.5 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF1749 PF08538.8 001112613.1_40423001_1 - 0.19 10.7 0.0 0.29 10.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Pkinase PF00069.23 001101725.1_37926001_3 - 1.9e-60 204.3 0.0 2.7e-60 203.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001101725.1_37926001_3 - 1.4e-36 126.0 0.0 2e-36 125.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 001101725.1_37926001_3 - 2.1e-32 110.6 32.6 2.1e-17 62.6 5.8 2.8 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C2 PF00168.28 001101725.1_37926001_3 - 1.5e-26 92.5 0.1 2.4e-26 91.9 0.1 1.3 1 0 0 1 1 1 1 C2 domain Pkinase_C PF00433.22 001101725.1_37926001_3 - 3.9e-09 36.9 1.4 8.6e-09 35.8 1.4 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 001101725.1_37926001_3 - 0.014 14.6 0.0 0.028 13.6 0.0 1.4 1 0 0 1 1 1 0 Kinase-like CEP76-C2 PF15627.4 001101725.1_37926001_3 - 0.015 14.7 0.0 0.028 13.9 0.0 1.3 1 0 0 1 1 1 0 CEP76 C2 domain C1_2 PF03107.14 001101725.1_37926001_3 - 0.025 14.8 24.1 0.25 11.6 7.7 3.0 3 0 0 3 3 3 0 C1 domain APH PF01636.21 001101725.1_37926001_3 - 0.095 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family PHD_2 PF13831.4 001101725.1_37926001_3 - 5.3 6.5 18.6 1.1 8.8 1.1 3.3 3 0 0 3 3 3 0 PHD-finger FYVE_2 PF02318.14 001101725.1_37926001_3 - 7.8 6.6 12.5 2.3 8.3 1.3 2.7 2 0 0 2 2 2 0 FYVE-type zinc finger Insulin PF00049.16 001082498.2_21022001_1 - 7.9e-16 58.7 4.8 5.1e-13 49.7 4.8 2.6 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Tubulin PF00091.23 001040008.1_45724001_1 - 1.5e-67 227.5 0.0 2.1e-67 227.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001040008.1_45724001_1 - 2.3e-51 173.2 0.0 3.6e-51 172.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 001040008.1_45724001_1 - 0.0016 18.0 0.0 0.0031 17.1 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain PGK PF00162.17 001083594.1_21023001_1 - 1e-151 505.1 0.3 1.2e-151 504.9 0.3 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Ribosomal_S26e PF01283.17 001009435.1_39521001_1 - 2e-54 182.5 6.6 2.3e-54 182.3 6.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e Fer4_7 PF12838.5 001009435.1_39521001_1 - 0.015 15.8 0.9 0.19 12.2 0.6 2.2 2 0 0 2 2 2 0 4Fe-4S dicluster domain EamA PF00892.18 001080786.1_39723001_1 - 2.7e-11 43.6 17.9 9.4e-06 25.7 0.6 2.4 2 1 0 2 2 2 2 EamA-like transporter family Pyridoxal_deC PF00282.17 213854.1_49824001_2 - 4.5e-171 568.5 0.0 5.5e-171 568.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.19 213854.1_49824001_2 - 3.4e-07 29.7 0.0 6.9e-07 28.7 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.19 213854.1_49824001_2 - 0.13 11.3 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II E1-E2_ATPase PF00122.18 214291.1_49827001_1 - 4.4e-55 186.2 0.9 4.4e-55 186.2 0.9 2.0 1 1 1 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 214291.1_49827001_1 - 2.5e-40 138.0 0.8 2.5e-40 138.0 0.8 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus H-K_ATPase_N PF09040.9 214291.1_49827001_1 - 1.3e-23 83.1 8.4 2e-23 82.4 8.4 1.3 1 0 0 1 1 1 1 Gastric H+/K+-ATPase, N terminal domain Cation_ATPase PF13246.4 214291.1_49827001_1 - 3.8e-23 81.2 0.0 7.1e-23 80.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 214291.1_49827001_1 - 1.9e-16 60.9 0.0 1.1e-13 51.8 0.0 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 214291.1_49827001_1 - 2.3e-15 55.9 0.0 4.6e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 214291.1_49827001_1 - 6.5e-05 22.6 2.6 0.00032 20.4 1.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 214291.1_49827001_1 - 0.089 13.1 0.1 0.55 10.5 0.1 2.2 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Nucleos_tra2_N PF01773.18 214291.1_49827001_1 - 4.9 7.7 10.7 0.65 10.5 0.5 3.1 3 0 0 3 3 3 0 Na+ dependent nucleoside transporter N-terminus FRG1 PF06229.10 004477.2_26223001_3 - 6.8e-80 267.2 0.2 6.8e-80 267.2 0.2 1.7 2 0 0 2 2 2 1 FRG1-like domain Fascin PF06268.11 004477.2_26223001_3 - 9.7e-07 28.9 0.0 3e-06 27.3 0.0 1.8 1 1 0 1 1 1 1 Fascin domain DUF2235 PF09994.7 004477.2_26223001_3 - 0.0038 16.5 0.0 0.0059 15.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF569 PF04601.11 004477.2_26223001_3 - 0.0045 16.6 0.0 0.099 12.2 0.0 2.8 1 1 1 2 2 2 1 Domain of unknown function (DUF569) CD225 PF04505.10 001136124.1_45722001_3 - 1.6e-30 104.9 1.5 3e-30 104.0 1.5 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein Pkinase PF00069.23 053749.1_45724001_2 - 5.7e-71 238.8 0.0 7.1e-71 238.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 053749.1_45724001_2 - 1.1e-40 139.5 0.0 1.4e-40 139.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 053749.1_45724001_2 - 0.0014 17.9 0.0 0.0028 16.9 0.0 1.5 1 1 1 2 2 2 1 Kinase-like TAS2R PF05296.11 001009139.1_39723001_1 - 2.4e-63 213.9 31.2 2.9e-63 213.6 31.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) RDD PF06271.10 001009139.1_39723001_1 - 2.1 8.4 16.3 0.016 15.2 4.8 2.8 1 1 0 2 2 2 0 RDD family Ras PF00071.20 001123178.1_49822001_1 - 1.6e-44 151.3 0.1 1.9e-44 151.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001123178.1_49822001_1 - 8.8e-30 103.3 0.0 1.4e-29 102.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001123178.1_49822001_1 - 5.1e-14 52.0 0.0 6.8e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001123178.1_49822001_1 - 1.1e-06 28.6 0.0 2e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001123178.1_49822001_1 - 0.0047 16.2 0.0 0.006 15.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001123178.1_49822001_1 - 0.016 14.5 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Dynamin_N PF00350.21 001123178.1_49822001_1 - 0.062 13.2 0.0 1.4 8.8 0.0 2.3 2 1 0 2 2 2 0 Dynamin family TniB PF05621.9 001123178.1_49822001_1 - 0.066 12.3 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein GTP_EFTU PF00009.25 001123178.1_49822001_1 - 0.16 11.4 0.0 2 7.8 0.0 2.2 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain p450 PF00067.20 001044770.2_45725001_2 - 3.2e-132 441.4 0.0 4.2e-132 441.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BEX PF04538.10 001037365.1_45722001_1 - 1.5e-13 51.3 22.7 3.2e-13 50.3 22.7 1.5 1 1 0 1 1 1 1 Brain expressed X-linked like family Serpin PF00079.18 001081947.1_21025001_2 - 1.2e-134 449.2 0.4 1.4e-134 448.9 0.4 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) CD4-extracel PF09191.8 001082313.2_37923001_3 - 1.2e-49 167.1 1.2 4.2e-49 165.3 0.5 2.4 2 0 0 2 2 2 1 CD4, extracellular C2-set PF05790.13 001082313.2_37923001_3 - 6.7e-43 144.6 11.7 8.2e-23 80.3 0.1 4.2 4 0 0 4 4 4 2 Immunoglobulin C2-set domain ig PF00047.23 001082313.2_37923001_3 - 3.9e-18 65.3 3.7 3.3e-14 52.7 0.0 4.5 4 2 0 4 4 4 2 Immunoglobulin domain Tcell_CD4_C PF12104.6 001082313.2_37923001_3 - 7e-16 57.7 8.7 2.5e-15 56.0 8.7 2.0 1 0 0 1 1 1 1 T cell CD4 receptor C terminal region V-set PF07686.15 001082313.2_37923001_3 - 3.2e-12 46.5 0.0 3.6e-09 36.6 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 001082313.2_37923001_3 - 1.3e-09 38.4 3.0 4.3e-05 23.9 0.1 4.0 4 1 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.4 001082313.2_37923001_3 - 2.5e-09 37.2 0.8 0.021 15.0 0.0 4.2 2 1 1 3 3 3 2 Immunoglobulin domain I-set PF07679.14 001082313.2_37923001_3 - 1.5e-06 28.0 1.6 0.0026 17.6 0.0 4.1 3 1 1 4 4 4 2 Immunoglobulin I-set domain Receptor_2B4 PF11465.6 001082313.2_37923001_3 - 2.8e-05 24.1 0.5 0.00012 22.1 0.1 2.2 2 0 0 2 2 2 1 Natural killer cell receptor 2B4 Herpes_gE PF02480.14 001082313.2_37923001_3 - 0.0002 20.1 0.0 0.0091 14.7 0.1 2.2 2 0 0 2 2 2 1 Alphaherpesvirus glycoprotein E Izumo-Ig PF16706.3 001082313.2_37923001_3 - 0.00033 20.5 0.0 0.2 11.6 0.0 3.1 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Ig_5 PF16681.3 001082313.2_37923001_3 - 0.0034 17.6 0.4 1.7 9.0 0.2 3.9 3 1 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DUF2103 PF09876.7 001082313.2_37923001_3 - 0.15 11.9 0.1 0.46 10.4 0.0 1.8 2 0 0 2 2 2 0 Predicted metal-binding protein (DUF2103) 7tm_4 PF13853.4 001009162.1_39722001_1 - 1.5e-58 198.6 20.0 1.8e-58 198.3 20.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001009162.1_39722001_1 - 4.4e-23 81.7 23.6 2.3e-22 79.4 23.6 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009162.1_39722001_1 - 2.1e-05 23.9 17.9 4e-05 23.0 17.9 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001009162.1_39722001_1 - 0.0045 16.2 12.2 0.0045 16.2 12.2 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Ribosomal_S28e PF01200.16 001001587.1_49821001_1 - 8.2e-35 118.5 0.9 1e-34 118.2 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S28e Pec_lyase_C PF00544.17 001001587.1_49821001_1 - 0.23 10.9 0.1 0.33 10.4 0.1 1.3 1 1 0 1 1 1 0 Pectate lyase AA_permease PF00324.19 001082703.2_37928001_2 - 6.8e-65 219.4 34.4 6.1e-40 137.1 4.8 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.13 001082703.2_37928001_2 - 2.2e-47 161.9 3.4 9.4e-30 103.8 1.7 3.0 1 1 1 2 2 2 2 Solute carrier family 12 7tm_1 PF00001.19 001033915.1_39723001_1 - 4.6e-59 199.7 28.3 6.7e-59 199.2 28.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001033915.1_39723001_1 - 3e-09 36.5 26.7 3.7e-09 36.2 26.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001033915.1_39723001_1 - 6.2e-06 25.6 28.0 9.7e-06 25.0 28.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001033915.1_39723001_1 - 0.00042 20.0 20.9 0.00082 19.1 20.9 1.4 1 1 0 1 1 1 1 Olfactory receptor MWFE PF15879.3 001033915.1_39723001_1 - 0.19 11.8 0.9 0.93 9.6 0.1 2.5 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit DUF2384 PF09722.8 001033915.1_39723001_2 - 0.083 12.8 0.2 0.53 10.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2384) Ion_trans PF00520.29 001101720.1_37929001_1 - 6.1e-255 840.9 82.9 6.9e-72 241.5 17.2 4.1 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.3 001101720.1_37929001_1 - 2.1e-35 120.2 0.0 5.6e-35 118.9 0.0 1.8 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 001101720.1_37929001_1 - 6.2e-29 100.0 0.1 1.4e-28 98.8 0.1 1.6 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 001101720.1_37929001_1 - 1.7e-10 40.0 29.7 3e-10 39.2 7.6 9.0 6 4 1 7 7 7 2 Polycystin cation channel CAC1F_C PF16885.3 001101720.1_37929001_1 - 6.1e-08 32.6 0.5 1.7e-05 24.5 0.0 2.4 2 0 0 2 2 2 2 Voltage-gated calcium channel subunit alpha, C-term COX16 PF14138.4 001101720.1_37929001_1 - 0.29 11.6 1.5 8.6 6.8 0.0 3.3 3 0 0 3 3 3 0 Cytochrome c oxidase assembly protein COX16 DUF2670 PF10875.6 001101720.1_37929001_1 - 1.5 8.8 3.8 4.2 7.4 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2670) Ras PF00071.20 001032357.1_49822001_2 - 7.5e-56 188.1 0.0 9.3e-56 187.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001032357.1_49822001_2 - 3.6e-30 104.5 0.0 5.1e-30 104.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001032357.1_49822001_2 - 1.3e-10 40.9 0.0 1.7e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001032357.1_49822001_2 - 0.0024 17.3 0.0 0.0043 16.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001032357.1_49822001_2 - 0.0058 16.6 0.0 0.0082 16.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001032357.1_49822001_2 - 0.02 14.7 0.1 6.8 6.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Defensin_propep PF00879.16 001141938.1_40422001_2 - 1.9e-21 76.0 3.2 3e-21 75.3 3.2 1.3 1 0 0 1 1 1 1 Defensin propeptide GRP PF07172.9 001141938.1_40422001_2 - 0.017 15.7 1.9 0.36 11.4 0.7 2.1 2 0 0 2 2 2 0 Glycine rich protein family OAD_gamma PF04277.11 001141938.1_40422001_2 - 0.018 15.5 5.5 0.56 10.7 5.0 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain ETRAMP PF09716.8 001141938.1_40422001_2 - 0.18 11.7 8.9 3 7.9 9.8 2.0 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) AP3D1 PF06375.9 001141938.1_40422001_2 - 7.4 6.7 15.2 11 6.1 15.2 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 SR-25 PF10500.7 001141938.1_40422001_3 - 0.49 9.8 19.3 0.71 9.3 19.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase_Tyr PF07714.15 214329.1_49825001_2 - 2.5e-60 203.9 0.0 3.3e-60 203.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 214329.1_49825001_2 - 3.3e-55 187.1 0.0 4.8e-55 186.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain RBD PF02196.13 214329.1_49825001_2 - 5.7e-24 83.9 0.1 1e-23 83.1 0.1 1.4 1 0 0 1 1 1 1 Raf-like Ras-binding domain C1_1 PF00130.20 214329.1_49825001_2 - 1.6e-10 40.6 10.2 2.8e-10 39.8 10.2 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.4 214329.1_49825001_2 - 7.7e-08 31.8 0.0 1.1e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like zf-RING-like PF08746.9 214329.1_49825001_2 - 0.0029 17.8 4.7 0.0076 16.4 4.7 1.7 1 0 0 1 1 1 1 RING-like domain APH PF01636.21 214329.1_49825001_2 - 0.013 15.3 0.5 0.21 11.3 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family TUG-UBL1 PF11470.6 214329.1_49825001_2 - 0.084 13.0 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 TUG ubiquitin-like domain Kdo PF06293.12 214329.1_49825001_2 - 0.13 11.5 0.2 0.22 10.7 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ANP PF00212.16 001009244.1_22422001_3 - 2.2e-12 46.8 11.3 3.9e-12 46.0 11.3 1.4 1 0 0 1 1 1 1 Atrial natriuretic peptide DOCK-C2 PF14429.4 001130049.1_26228001_2 - 1.2e-53 181.6 0.1 3.1e-53 180.3 0.1 1.7 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.6 001130049.1_26228001_2 - 3.7e-33 113.6 0.2 9e-33 112.4 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PH PF00169.27 001130049.1_26228001_2 - 3e-13 50.0 0.2 6.5e-13 49.0 0.2 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 001130049.1_26228001_2 - 0.00029 21.1 0.0 0.00069 19.8 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain BAAT_C PF08840.9 017300.2_45724001_3 - 4.7e-76 255.3 0.0 7.1e-76 254.7 0.0 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Bile_Hydr_Trans PF04775.12 017300.2_45724001_3 - 4e-42 143.0 0.0 6e-42 142.5 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA thioester hydrolase/BAAT N-terminal region DLH PF01738.16 017300.2_45724001_3 - 1.3e-05 24.8 0.0 0.00061 19.3 0.0 2.4 1 1 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.19 017300.2_45724001_3 - 0.0026 17.1 0.0 0.0056 16.0 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family RVP_2 PF08284.9 001040611.1_32929001_1 - 0.042 13.7 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease_2 PF13650.4 001040611.1_32929001_1 - 0.047 14.2 0.0 0.079 13.5 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease GerPC PF10737.7 001040611.1_32929001_1 - 0.18 11.7 3.0 0.31 11.0 3.0 1.3 1 0 0 1 1 1 0 Spore germination protein GerPC Retrotrans_gag PF03732.15 001040611.1_32929001_2 - 2.4e-16 59.7 0.0 4.6e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 Retrotransposon gag protein DUF4939 PF16297.3 001040611.1_32929001_2 - 4.6e-13 48.9 0.0 8.7e-13 48.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) zf-CCHC_5 PF14787.4 001040611.1_32929001_2 - 0.00075 19.0 0.3 0.0018 17.8 0.3 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger MOZ_SAS PF01853.16 001005872.1_45724001_3 - 3.1e-84 280.9 1.1 3.1e-84 280.9 1.1 1.6 2 0 0 2 2 2 1 MOZ/SAS family Tudor-knot PF11717.6 001005872.1_45724001_3 - 2e-18 65.9 0.1 4.5e-18 64.8 0.1 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.5 001005872.1_45724001_3 - 0.0012 19.0 0.0 0.0028 17.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.23 001005872.1_45724001_3 - 0.014 15.5 0.0 0.028 14.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Phosphorylase PF00343.18 001082184.1_37926001_3 - 0 1155.3 0.0 0 1155.1 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase COX_ARM PF06481.12 001082184.1_37926001_3 - 0.018 14.8 0.1 0.052 13.3 0.1 1.8 1 0 0 1 1 1 0 COX Aromatic Rich Motif Rsa3 PF14615.4 001082184.1_37926001_3 - 0.021 14.2 0.1 2.2 7.8 0.0 2.7 2 0 0 2 2 2 0 Ribosome-assembly protein 3 TAS2R PF05296.11 001009142.1_39722001_1 - 3.5e-111 371.0 35.9 4e-111 370.8 35.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) PDR_CDR PF06422.10 001009142.1_39722001_1 - 6.5 6.6 11.0 0.16 11.8 0.3 2.9 1 1 2 3 3 3 0 CDR ABC transporter T6SS_TssG PF06996.9 001009142.1_39722001_3 - 0.14 11.2 0.1 0.2 10.7 0.1 1.1 1 0 0 1 1 1 0 Type VI secretion, TssG 7tm_1 PF00001.19 001001538.1_49824001_3 - 1.2e-58 198.4 28.2 1.7e-58 197.9 28.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001001538.1_49824001_3 - 6.8e-09 35.3 26.6 8.7e-09 35.0 26.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001001538.1_49824001_3 - 1.5e-05 24.3 27.2 2.4e-05 23.7 27.2 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001001538.1_49824001_3 - 0.0025 17.4 20.4 0.0055 16.3 20.4 1.5 1 1 0 1 1 1 1 Olfactory receptor P34-Arc PF04045.12 001133176.1_43523001_1 - 1.5e-103 345.5 0.8 2e-103 345.1 0.8 1.2 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Tmemb_161AB PF10268.7 001133176.1_43523001_3 - 0.77 8.3 4.8 0.99 7.9 4.8 1.1 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB Complex1_49kDa PF00346.17 001071826.1_39723001_1 - 2.8e-129 429.9 0.0 3.9e-129 429.4 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.17 001071826.1_39723001_1 - 0.031 13.0 0.0 0.046 12.5 0.0 1.2 1 0 0 1 1 1 0 Nickel-dependent hydrogenase Ferritin PF00210.22 213975.1_49822001_2 - 8.6e-32 109.9 3.4 1.2e-31 109.5 3.4 1.2 1 0 0 1 1 1 1 Ferritin-like domain Transthyretin PF00576.19 001032968.1_32322001_3 - 2.1e-21 76.5 0.4 6.5e-21 75.0 0.2 1.7 2 0 0 2 2 2 1 HIUase/Transthyretin family B56 PF01603.18 001082364.1_37924001_3 - 1.8e-199 662.8 11.6 1.8e-199 662.8 11.6 1.4 2 0 0 2 2 2 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.5 001082364.1_37924001_3 - 0.15 11.9 2.1 3.3 7.5 0.2 2.8 1 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal PP1_inhibitor PF05361.10 214337.1_49822001_2 - 2.6e-62 208.9 0.2 3.2e-62 208.6 0.2 1.0 1 0 0 1 1 1 1 PKC-activated protein phosphatase-1 inhibitor CENP-R PF06729.10 001013213.1_45723001_3 - 4.8e-56 188.4 5.9 4.8e-56 188.4 5.9 2.1 2 0 0 2 2 2 1 Kinetochore component, CENP-R CRIM PF16978.3 001009768.1_39524001_1 - 1.5e-35 122.3 0.0 3.9e-35 120.9 0.0 1.7 2 0 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1 PF05422.10 001009768.1_39524001_1 - 6.7e-31 107.6 12.1 1.7e-29 103.1 8.2 3.3 2 1 0 2 2 2 1 Stress-activated map kinase interacting protein 1 (SIN1) SIN1_PH PF16979.3 001009768.1_39524001_1 - 1e-30 106.1 0.2 2.3e-30 105.0 0.2 1.6 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology VPS9 PF02204.16 001009768.1_39524001_1 - 0.011 15.8 0.0 0.051 13.7 0.0 2.2 2 0 0 2 2 2 0 Vacuolar sorting protein 9 (VPS9) domain Pkinase PF00069.23 001101724.1_37926001_1 - 6e-65 219.1 0.0 9e-65 218.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001101724.1_37926001_1 - 7.6e-38 130.1 0.0 1.1e-37 129.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 001101724.1_37926001_1 - 7.7e-33 112.0 26.7 2.1e-16 59.4 4.9 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C2 PF00168.28 001101724.1_37926001_1 - 1.2e-28 99.2 0.1 2e-28 98.6 0.1 1.3 1 0 0 1 1 1 1 C2 domain Pkinase_C PF00433.22 001101724.1_37926001_1 - 0.00043 20.8 0.6 0.0012 19.4 0.6 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain C1_2 PF03107.14 001101724.1_37926001_1 - 0.0037 17.4 21.2 0.22 11.7 5.4 2.5 2 0 0 2 2 2 2 C1 domain Kinase-like PF14531.4 001101724.1_37926001_1 - 0.19 10.9 0.0 0.33 10.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like PHD_2 PF13831.4 001101724.1_37926001_1 - 0.27 10.7 14.0 1.2 8.6 1.7 2.8 2 0 0 2 2 2 0 PHD-finger PHD PF00628.27 001101724.1_37926001_1 - 0.54 10.1 21.4 0.4 10.5 4.3 2.6 2 0 0 2 2 2 0 PHD-finger zf-RING_9 PF13901.4 001101724.1_37926001_1 - 4.9 6.9 20.1 4.4 7.1 2.8 2.3 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon RYDR_ITPR PF01365.19 001001534.1_49829001_1 - 2.7e-133 441.6 14.0 1.6e-70 236.6 0.0 4.1 4 0 0 4 4 4 2 RIH domain RyR PF02026.14 001001534.1_49829001_1 - 9e-122 397.4 1.3 2.7e-33 113.9 0.0 4.8 4 0 0 4 4 4 4 RyR domain RR_TM4-6 PF06459.10 001001534.1_49829001_1 - 1e-78 264.9 14.0 5.6e-75 252.6 0.0 3.9 5 0 0 5 5 4 1 Ryanodine Receptor TM 4-6 SPRY PF00622.26 001001534.1_49829001_1 - 2.2e-68 227.8 0.5 1.6e-22 79.8 0.0 3.5 3 0 0 3 3 3 3 SPRY domain Ins145_P3_rec PF08709.9 001001534.1_49829001_1 - 5.4e-61 205.4 0.0 2.5e-60 203.2 0.0 2.2 2 1 1 3 3 3 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.17 001001534.1_49829001_1 - 5.9e-55 185.9 0.0 6.1e-52 176.0 0.0 2.6 2 0 0 2 2 2 2 MIR domain RIH_assoc PF08454.9 001001534.1_49829001_1 - 1.7e-32 111.1 0.3 2.6e-31 107.3 0.2 3.2 3 1 0 3 3 2 1 RyR and IP3R Homology associated Ion_trans PF00520.29 001001534.1_49829001_1 - 1e-13 50.9 3.7 1e-13 50.9 3.7 1.8 2 0 0 2 2 2 1 Ion transport protein EF-hand_8 PF13833.4 001001534.1_49829001_1 - 1.9e-07 30.6 0.1 6.6e-07 28.9 0.1 2.0 1 0 0 1 1 1 1 EF-hand domain pair DUF1510 PF07423.9 001001534.1_49829001_1 - 0.0067 15.8 14.3 0.034 13.5 14.3 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) EF-hand_7 PF13499.4 001001534.1_49829001_1 - 0.028 14.8 0.2 0.13 12.7 0.2 2.3 1 0 0 1 1 1 0 EF-hand domain pair DUF913 PF06025.10 001001534.1_49829001_1 - 0.12 11.2 1.7 0.51 9.1 1.7 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF1840 PF08895.9 001001534.1_49829001_1 - 0.37 11.0 13.1 12 6.2 11.2 4.4 3 1 0 3 3 3 0 Domain of unknown function (DUF1840) Presenilin PF01080.15 001001534.1_49829001_1 - 0.5 8.9 3.1 1.5 7.4 3.1 1.7 1 0 0 1 1 1 0 Presenilin Serglycin PF04360.10 001001534.1_49829001_1 - 1.2 8.9 3.7 2.9 7.7 3.7 1.5 1 0 0 1 1 1 0 Serglycin Tim54 PF11711.6 001001534.1_49829001_1 - 1.4 7.5 9.9 5.6 5.5 9.9 2.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RRN3 PF05327.9 001001534.1_49829001_1 - 2.9 6.2 12.8 6.7 5.0 12.8 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.12 001001534.1_49829001_1 - 3.5 5.7 20.0 0.97 7.5 15.8 2.1 2 0 0 2 2 2 0 CDC45-like protein SpoIIP PF07454.9 001001534.1_49829001_1 - 4.9 6.4 9.8 12 5.1 9.8 1.6 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Urb2 PF10441.7 001001534.1_49829001_1 - 6.3 6.5 6.3 4.2 7.1 0.1 3.8 5 1 1 6 6 5 0 Urb2/Npa2 family DUF719 PF05334.11 001001534.1_49829001_1 - 9.8 6.2 9.1 51 3.9 9.1 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF719) Peptidase_M1 PF01433.18 214277.1_49827001_1 - 9.7e-142 472.7 0.0 1.9e-141 471.8 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M1 ERAP1_C PF11838.6 214277.1_49827001_1 - 3.6e-83 279.6 1.8 3.6e-83 279.6 1.8 2.0 3 0 0 3 3 3 1 ERAP1-like C-terminal domain Aminopep PF10023.7 214277.1_49827001_1 - 0.053 12.7 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative aminopeptidase Neogenin_C PF06583.10 012841.1_45729001_3 - 3.5e-107 358.5 15.9 6.5e-107 357.6 15.9 1.5 1 0 0 1 1 1 1 Neogenin C-terminus fn3 PF00041.19 012841.1_45729001_3 - 7.6e-77 253.6 16.5 1.6e-15 57.1 0.4 6.5 6 0 0 6 6 6 6 Fibronectin type III domain I-set PF07679.14 012841.1_45729001_3 - 3e-59 196.9 0.0 2.5e-16 59.4 0.0 5.7 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_3 PF13927.4 012841.1_45729001_3 - 3e-56 187.8 0.3 2.2e-14 53.7 0.0 6.5 7 0 0 7 7 5 4 Immunoglobulin domain Ig_2 PF13895.4 012841.1_45729001_3 - 7.6e-41 138.2 0.0 7.3e-11 42.1 0.1 4.7 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 012841.1_45729001_3 - 6.6e-38 128.6 0.0 3.8e-12 46.1 0.0 5.1 5 0 0 5 5 5 4 Immunoglobulin domain V-set PF07686.15 012841.1_45729001_3 - 3.5e-21 75.3 0.5 5.3e-05 23.2 0.3 8.2 6 3 0 6 6 6 3 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.3 012841.1_45729001_3 - 5.7e-16 58.7 12.0 0.00048 20.5 6.1 6.4 5 2 0 5 5 5 4 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.10 012841.1_45729001_3 - 3.2e-10 39.8 0.0 0.11 12.4 0.0 5.2 5 0 0 5 5 4 2 CD80-like C2-set immunoglobulin domain Interfer-bind PF09294.8 012841.1_45729001_3 - 2.5e-07 30.8 0.1 0.11 12.6 0.0 5.0 5 0 0 5 5 5 2 Interferon-alpha/beta receptor, fibronectin type III Ig_5 PF16681.3 012841.1_45729001_3 - 4.4e-07 30.1 0.0 3.8 7.8 0.0 4.6 4 0 0 4 4 4 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain EphA2_TM PF14575.4 012841.1_45729001_3 - 0.00061 20.4 0.1 0.0037 17.9 0.1 2.2 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain DUF2369 PF10179.7 012841.1_45729001_3 - 0.00065 20.0 0.0 1.8 9.0 0.0 4.4 5 0 0 5 5 4 1 Uncharacterised conserved protein (DUF2369) Sp38 PF07354.10 012841.1_45729001_3 - 0.00068 18.5 0.0 0.016 14.0 0.0 2.2 2 0 0 2 2 2 1 Zona-pellucida-binding protein (Sp38) CD34_antigen PF06365.10 012841.1_45729001_3 - 0.0034 16.9 0.0 0.0075 15.8 0.0 1.5 1 0 0 1 1 1 1 CD34/Podocalyxin family FAM176 PF14851.4 012841.1_45729001_3 - 0.0041 16.7 0.7 0.012 15.2 0.0 2.0 2 0 0 2 2 2 1 FAM176 family Herpes_gE PF02480.14 012841.1_45729001_3 - 0.0062 15.2 0.1 4.9 5.6 0.0 3.2 4 0 0 4 4 4 1 Alphaherpesvirus glycoprotein E V-set_CD47 PF08204.9 012841.1_45729001_3 - 0.012 15.5 0.0 0.054 13.3 0.0 2.0 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain C1-set PF07654.13 012841.1_45729001_3 - 0.017 15.4 0.9 1.9 8.9 0.0 4.3 5 0 0 5 5 5 0 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 012841.1_45729001_3 - 0.033 14.1 0.0 7.2 6.6 0.0 3.3 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain LYRIC PF15686.3 012841.1_45729001_3 - 0.037 13.4 0.1 0.072 12.5 0.1 1.4 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family DUF4998 PF16389.3 012841.1_45729001_3 - 0.046 13.2 0.0 0.31 10.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function Ly49 PF08391.8 012841.1_45729001_3 - 0.065 13.5 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Adeno_E3_CR1 PF02440.13 012841.1_45729001_3 - 0.081 12.6 0.0 9.2 6.0 0.0 2.7 2 0 0 2 2 2 0 Adenovirus E3 region protein CR1 TMEM154 PF15102.4 012841.1_45729001_3 - 0.22 11.3 1.4 0.72 9.6 0.0 2.4 2 0 0 2 2 2 0 TMEM154 protein family Cadherin_C_2 PF16492.3 012841.1_45729001_3 - 0.46 11.2 0.0 0.46 11.2 0.0 2.5 3 0 0 3 3 2 0 Cadherin cytoplasmic C-terminal Ribosomal_L7Ae PF01248.24 212515.2_45722001_1 - 6.3e-25 86.6 0.2 9.2e-25 86.1 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.9 212515.2_45722001_1 - 0.00071 19.5 0.1 0.00098 19.1 0.1 1.2 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.4 212515.2_45722001_1 - 0.031 14.0 0.0 0.046 13.5 0.0 1.3 1 0 0 1 1 1 0 PELOTA RNA binding domain HCO3_cotransp PF00955.19 001082319.1_37928001_3 - 9.1e-214 710.9 2.9 1.2e-213 710.5 2.9 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 001082319.1_37928001_3 - 1.9e-105 352.4 0.1 2.8e-105 351.8 0.1 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.20 001082319.1_37928001_3 - 0.00017 21.4 0.0 0.00031 20.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Cytochrom_B_C PF00032.15 001082319.1_37928001_3 - 2.2 8.5 7.0 2.8 8.1 0.2 3.2 3 1 0 3 3 3 0 Cytochrome b(C-terminal)/b6/petD Aldedh PF00171.20 001082013.1_37925001_2 - 1.5e-179 597.2 0.0 1.8e-179 597.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.12 001082013.1_37925001_2 - 0.00068 18.7 0.0 0.0011 17.9 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF1487 PF07368.9 001082013.1_37925001_2 - 0.087 12.1 0.0 0.29 10.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) UCH PF00443.27 053774.2_45725001_2 - 5.4e-72 242.2 0.0 7.7e-72 241.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 053774.2_45725001_2 - 1.9e-18 67.0 0.0 2.8e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Globin PF00042.20 001168847.1_40421001_1 - 2e-32 111.9 0.2 4.1e-31 107.6 0.0 2.0 2 0 0 2 2 2 1 Globin BCA_ABC_TP_C PF12399.6 001168847.1_40421001_1 - 0.028 14.2 0.4 1.5 8.7 0.0 2.5 2 0 0 2 2 2 0 Branched-chain amino acid ATP-binding cassette transporter TAS2R PF05296.11 001009130.1_39723001_1 - 3.2e-70 236.5 30.3 3.7e-70 236.3 30.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Defensin_propep PF00879.16 001141941.1_40421001_1 - 7.9e-23 80.4 6.4 9.8e-23 80.1 6.4 1.1 1 0 0 1 1 1 1 Defensin propeptide S_100 PF01023.17 001081841.1_21021001_2 - 9e-17 60.4 0.2 1.7e-16 59.5 0.2 1.5 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 001081841.1_21021001_2 - 1.9e-07 31.3 0.5 2.8e-07 30.8 0.5 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001081841.1_21021001_2 - 0.00087 18.5 0.3 0.006 15.9 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 001081841.1_21021001_2 - 0.026 14.2 0.2 0.037 13.7 0.2 1.2 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.4 001081841.1_21021001_2 - 0.039 13.8 0.2 7.7 6.6 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain Taxilin PF09728.7 001009080.1_39722001_3 - 0.0044 16.2 0.1 0.0075 15.4 0.1 1.3 1 0 0 1 1 1 1 Myosin-like coiled-coil protein Ras PF00071.20 001082251.2_37923001_1 - 8.5e-63 210.6 0.1 1.1e-62 210.3 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001082251.2_37923001_1 - 8e-35 119.5 0.1 1.3e-34 118.8 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001082251.2_37923001_1 - 1e-11 44.5 0.0 1.5e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001082251.2_37923001_1 - 7.4e-07 29.1 0.1 1.1e-06 28.5 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 001082251.2_37923001_1 - 0.00019 21.6 0.0 0.0014 18.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.14 001082251.2_37923001_1 - 0.00022 21.1 0.2 0.036 13.8 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001082251.2_37923001_1 - 0.00056 19.4 0.1 0.0014 18.0 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.4 001082251.2_37923001_1 - 0.025 14.8 0.1 0.044 14.0 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain Gtr1_RagA PF04670.10 001082251.2_37923001_1 - 0.025 13.8 0.0 0.042 13.1 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region ABC_tran PF00005.25 001082251.2_37923001_1 - 0.042 14.2 0.1 0.078 13.4 0.1 1.4 1 1 0 1 1 1 0 ABC transporter FeoB_N PF02421.16 001082251.2_37923001_1 - 0.049 13.0 0.1 0.13 11.7 0.1 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.7 001082251.2_37923001_1 - 0.059 13.0 0.0 0.098 12.3 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.8 001082251.2_37923001_1 - 0.12 11.7 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.4 001082251.2_37923001_1 - 0.12 11.9 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Defensin_propep PF00879.16 001141939.1_40422001_2 - 2.6e-23 82.0 4.5 4.7e-23 81.1 4.5 1.4 1 0 0 1 1 1 1 Defensin propeptide GRP PF07172.9 001141939.1_40422001_2 - 0.013 16.1 1.2 1.5 9.4 0.6 2.1 2 0 0 2 2 2 0 Glycine rich protein family OAD_gamma PF04277.11 001141939.1_40422001_2 - 0.24 11.9 4.1 3.8 8.0 2.6 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain RYDR_ITPR PF01365.19 001101718.1_37929001_3 - 1e-132 439.7 13.9 1.8e-70 236.4 0.0 4.3 4 0 0 4 4 4 2 RIH domain RyR PF02026.14 001101718.1_37929001_3 - 5.3e-122 398.2 1.5 1.6e-33 114.6 0.0 4.9 4 0 0 4 4 4 4 RyR domain RR_TM4-6 PF06459.10 001101718.1_37929001_3 - 9.9e-80 268.2 14.9 6.8e-76 255.6 0.0 3.7 5 0 0 5 5 3 2 Ryanodine Receptor TM 4-6 SPRY PF00622.26 001101718.1_37929001_3 - 4.7e-69 229.9 0.5 2.7e-22 79.0 0.0 3.5 3 0 0 3 3 3 3 SPRY domain Ins145_P3_rec PF08709.9 001101718.1_37929001_3 - 5.6e-62 208.6 0.0 2.3e-61 206.6 0.1 2.1 2 1 1 3 3 3 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.17 001101718.1_37929001_3 - 9.2e-55 185.2 0.0 2.5e-51 174.0 0.0 2.5 2 0 0 2 2 2 2 MIR domain RIH_assoc PF08454.9 001101718.1_37929001_3 - 1.6e-32 111.2 0.2 2.7e-31 107.3 0.2 3.2 3 1 0 3 3 3 1 RyR and IP3R Homology associated Ion_trans PF00520.29 001101718.1_37929001_3 - 1.1e-13 50.9 3.7 1.1e-13 50.9 3.7 1.8 2 0 0 2 2 2 1 Ion transport protein EF-hand_8 PF13833.4 001101718.1_37929001_3 - 6.6e-08 32.1 0.1 2.4e-07 30.3 0.1 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.4 001101718.1_37929001_3 - 0.0022 18.3 0.2 0.0095 16.3 0.2 2.2 1 0 0 1 1 1 1 EF-hand domain pair DUF1510 PF07423.9 001101718.1_37929001_3 - 0.0073 15.6 15.4 0.031 13.6 15.4 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) DUF913 PF06025.10 001101718.1_37929001_3 - 0.076 11.8 2.4 0.3 9.9 2.4 2.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DDHD PF02862.15 001101718.1_37929001_3 - 0.35 10.8 2.2 1.2 9.0 2.2 1.9 1 0 0 1 1 1 0 DDHD domain CDC45 PF02724.12 001101718.1_37929001_3 - 0.35 9.0 17.7 0.08 11.1 13.6 2.0 2 0 0 2 2 2 0 CDC45-like protein AIF_C PF14721.4 001101718.1_37929001_3 - 0.38 11.0 1.5 1.2 9.3 1.5 1.8 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Tim54 PF11711.6 001101718.1_37929001_3 - 0.71 8.5 9.8 3.2 6.3 9.8 2.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF1840 PF08895.9 001101718.1_37929001_3 - 0.85 9.8 15.2 20 5.5 11.8 4.5 3 1 0 3 3 3 0 Domain of unknown function (DUF1840) CPSF100_C PF13299.4 001101718.1_37929001_3 - 1.4 9.0 8.1 7.4 6.6 8.1 2.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RRN3 PF05327.9 001101718.1_37929001_3 - 2.2 6.6 13.2 5.2 5.4 13.2 1.6 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SpoIIP PF07454.9 001101718.1_37929001_3 - 2.7 7.2 9.9 6.3 6.0 9.9 1.5 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.15 001101718.1_37929001_3 - 4.9 5.7 6.1 13 4.3 6.1 1.6 1 0 0 1 1 1 0 Presenilin RP-C_C PF11800.6 001101718.1_37929001_3 - 5.5 6.9 8.5 22 4.9 7.2 2.7 2 0 0 2 2 2 0 Replication protein C C-terminal region MIP PF00230.18 001110424.1_49822001_2 - 3.2e-75 252.6 14.9 3.9e-75 252.3 14.9 1.0 1 0 0 1 1 1 1 Major intrinsic protein TBP PF00352.19 001104606.1_39723001_1 - 1.7e-65 216.8 0.4 1.1e-31 108.5 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.6 001104606.1_39723001_1 - 0.00034 20.5 0.0 1.1 9.3 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) Peptidase_M13_N PF05649.11 001101685.1_37926001_1 - 7.5e-110 368.0 1.2 1.2e-109 367.4 1.2 1.3 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.19 001101685.1_37926001_1 - 3.7e-72 242.1 0.5 6.9e-72 241.2 0.5 1.5 1 0 0 1 1 1 1 Peptidase family M13 SapB_2 PF03489.15 001082343.1_37924001_3 - 3.3e-23 81.3 9.7 7.5e-09 35.4 0.0 4.7 4 0 0 4 4 4 3 Saposin-like type B, region 2 SapA PF02199.13 001082343.1_37924001_3 - 6.9e-14 51.6 3.4 4.8e-13 48.9 3.4 2.6 1 0 0 1 1 1 1 Saposin A-type domain SapB_1 PF05184.13 001082343.1_37924001_3 - 3.3e-09 36.4 4.4 6.6e-07 29.1 2.4 3.6 3 0 0 3 3 3 2 Saposin-like type B, region 1 SCP2 PF02036.15 001082035.1_37926001_2 - 3.3e-29 101.2 0.4 5.9e-29 100.4 0.4 1.3 1 0 0 1 1 1 1 SCP-2 sterol transfer family Thiolase_N PF00108.21 001082035.1_37926001_2 - 4.6e-22 78.5 0.0 2.4e-20 72.9 0.0 2.4 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 001082035.1_37926001_2 - 1.1e-12 47.5 0.1 1.7e-11 43.7 0.0 2.7 1 1 1 2 2 2 1 Thiolase, C-terminal domain Alkyl_sulf_C PF14864.4 001082035.1_37926001_2 - 5.2e-06 26.6 0.0 9.1e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal ACP_syn_III PF08545.8 001082035.1_37926001_2 - 0.00044 19.9 0.1 0.064 13.0 0.1 2.6 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.24 001082035.1_37926001_2 - 0.0047 16.4 0.1 0.0099 15.3 0.1 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.20 001082035.1_37926001_2 - 0.007 16.3 0.2 0.31 11.0 0.0 2.7 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain SpoVAD PF07451.9 001082035.1_37926001_2 - 0.024 13.2 0.0 0.066 11.8 0.0 1.6 2 0 0 2 2 2 0 Stage V sporulation protein AD (SpoVAD) Macoilin PF09726.7 001038649.1_39725001_2 - 0 1114.5 18.4 0 1114.3 18.4 1.0 1 0 0 1 1 1 1 Transmembrane protein DUF812 PF05667.9 001038649.1_39725001_2 - 0.00034 19.5 39.6 0.00034 19.5 39.6 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF812) Reo_sigmaC PF04582.10 001038649.1_39725001_2 - 0.0021 17.4 8.2 0.073 12.3 0.6 2.2 2 0 0 2 2 2 2 Reovirus sigma C capsid protein GLE1 PF07817.11 001038649.1_39725001_2 - 0.68 8.9 12.9 0.67 9.0 0.1 2.3 2 0 0 2 2 2 0 GLE1-like protein FPP PF05911.9 001038649.1_39725001_2 - 6.8 4.7 55.5 0.27 9.3 29.5 2.4 2 1 1 3 3 3 0 Filament-like plant protein, long coiled-coil Amino_oxidase PF01593.22 001001864.1_49826001_3 - 2.4e-75 254.4 0.0 3e-75 254.1 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 001001864.1_49826001_3 - 8.1e-14 51.5 0.2 1.8e-13 50.4 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001001864.1_49826001_3 - 2.1e-06 27.5 0.0 3.6e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 001001864.1_49826001_3 - 2.9e-06 26.5 1.4 4.5e-06 25.9 1.4 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.5 001001864.1_49826001_3 - 5.2e-06 25.9 1.4 7.7e-06 25.4 1.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.12 001001864.1_49826001_3 - 2.1e-05 23.8 1.1 8.2e-05 21.9 0.3 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.17 001001864.1_49826001_3 - 3.4e-05 23.2 0.5 5.1e-05 22.6 0.5 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.15 001001864.1_49826001_3 - 5.1e-05 22.5 0.2 8.7e-05 21.7 0.2 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.25 001001864.1_49826001_3 - 9.6e-05 22.7 0.4 0.00025 21.4 0.4 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.12 001001864.1_49826001_3 - 0.00047 18.8 0.4 0.00087 18.0 0.4 1.4 1 0 0 1 1 1 1 HI0933-like protein AlaDh_PNT_C PF01262.19 001001864.1_49826001_3 - 0.00067 18.9 0.2 0.0011 18.1 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.4 001001864.1_49826001_3 - 0.00084 18.5 0.2 0.19 10.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase IlvN PF07991.10 001001864.1_49826001_3 - 0.018 14.5 0.2 0.033 13.6 0.2 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain GIDA PF01134.20 001001864.1_49826001_3 - 0.029 13.3 1.7 0.033 13.1 0.2 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A Lycopene_cycl PF05834.10 001001864.1_49826001_3 - 0.036 13.0 0.1 0.052 12.5 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein MCRA PF06100.9 001001864.1_49826001_3 - 0.061 12.0 0.0 0.096 11.3 0.0 1.2 1 0 0 1 1 1 0 MCRA family Trp_halogenase PF04820.12 001001864.1_49826001_3 - 0.31 9.7 0.6 0.45 9.2 0.6 1.2 1 0 0 1 1 1 0 Tryptophan halogenase eIF3_N PF09440.8 001011990.1_45724001_2 - 6.9e-47 159.1 3.9 2.8e-46 157.1 3.9 2.1 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.25 001011990.1_45724001_2 - 6.5e-20 71.5 0.2 2.6e-19 69.6 0.0 2.2 2 0 0 2 2 2 1 PCI domain CSN8_PSD8_EIF3K PF10075.7 001011990.1_45724001_2 - 0.023 14.5 0.6 0.1 12.4 0.0 2.3 3 0 0 3 3 3 0 CSN8/PSMD8/EIF3K family SPESP1 PF15754.3 001011990.1_45724001_2 - 0.036 13.1 0.2 6.2 5.8 0.1 2.3 2 0 0 2 2 2 0 Sperm equatorial segment protein 1 HD_assoc PF13286.4 001011990.1_45724001_2 - 0.074 13.5 1.3 3 8.3 0.2 2.6 2 0 0 2 2 2 0 Phosphohydrolase-associated domain B12D PF06522.9 001079924.2_39721001_3 - 8.1e-31 105.5 0.0 1e-30 105.2 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit Phe_ZIP PF08916.9 134456.3_45726001_1 - 4.4e-22 78.4 5.4 8.6e-22 77.5 5.4 1.5 1 0 0 1 1 1 1 Phenylalanine zipper SH2 PF00017.22 134456.3_45726001_1 - 1.7e-14 53.5 0.2 2.7e-14 52.8 0.2 1.4 1 0 0 1 1 1 1 SH2 domain PH PF00169.27 134456.3_45726001_1 - 6.7e-14 52.2 0.0 1.3e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 PH domain PI3K_rbd PF00794.16 134456.3_45726001_1 - 0.13 12.3 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 PI3-kinase family, ras-binding domain Mito_fiss_reg PF05308.9 134456.3_45726001_1 - 2.8 7.8 6.6 22 4.9 0.3 2.7 2 0 0 2 2 2 0 Mitochondrial fission regulator Pkinase PF00069.23 173986.2_06524001_1 - 3.4e-77 259.2 0.0 4.4e-77 258.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 173986.2_06524001_1 - 7.3e-36 123.7 0.0 1.1e-35 123.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.27 173986.2_06524001_1 - 9.2e-17 61.3 0.2 2.1e-16 60.2 0.2 1.6 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.22 173986.2_06524001_1 - 1.9e-10 41.2 3.7 4e-10 40.1 3.7 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 173986.2_06524001_1 - 2.1e-08 33.7 0.0 1e-07 31.4 0.0 1.9 2 0 0 2 2 2 1 Kinase-like PH_11 PF15413.4 173986.2_06524001_1 - 0.015 15.6 0.2 0.071 13.4 0.0 2.3 3 0 0 3 3 3 0 Pleckstrin homology domain Seadorna_VP7 PF07387.9 173986.2_06524001_1 - 0.088 11.7 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 TGFb_propeptide PF00688.16 001081849.1_21023001_3 - 3.3e-38 131.7 0.0 4.2e-38 131.4 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001081849.1_21023001_3 - 6.1e-22 78.4 1.7 1.2e-21 77.4 1.7 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain Phosphorylase PF00343.18 001009192.2_39526001_1 - 0 1161.9 0.0 0 1161.7 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase COX_ARM PF06481.12 001009192.2_39526001_1 - 0.021 14.6 0.2 0.061 13.1 0.2 1.8 1 0 0 1 1 1 0 COX Aromatic Rich Motif Rsa3 PF14615.4 001009192.2_39526001_1 - 0.041 13.3 0.2 2.2 7.8 0.0 2.6 2 0 0 2 2 2 0 Ribosome-assembly protein 3 IRK PF01007.18 214225.1_49824001_1 - 3.6e-144 479.6 1.1 4.4e-144 479.3 1.1 1.0 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 214225.1_49824001_1 - 0.022 14.6 7.2 0.051 13.4 7.2 1.7 1 1 0 1 1 1 0 Ion channel Phosphorylase PF00343.18 022268.1_45726001_1 - 0 1151.9 0.0 0 1151.7 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase DUF4181 PF13789.4 022268.1_45726001_1 - 0.17 12.1 0.5 0.48 10.6 0.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4181) FERM_M PF00373.16 001135504.1_43527001_3 - 4.9e-45 152.6 0.3 1.1e-44 151.5 0.3 1.6 1 0 0 1 1 1 1 FERM central domain PH PF00169.27 001135504.1_43527001_3 - 1.3e-11 44.8 0.0 3.9e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 PH domain FERM_N PF09379.8 001135504.1_43527001_3 - 0.07 12.9 0.0 0.45 10.4 0.0 2.3 2 1 0 2 2 2 0 FERM N-terminal domain RA PF00788.21 001135504.1_43527001_3 - 0.072 13.6 0.0 0.17 12.4 0.0 1.6 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain CaKB PF03185.13 001135504.1_43527001_3 - 0.11 12.0 0.1 0.25 10.9 0.1 1.5 1 0 0 1 1 1 0 Calcium-activated potassium channel, beta subunit ASC PF00858.22 001009072.1_39724001_1 - 9.6e-84 281.6 0.0 1.1e-83 281.3 0.0 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Resistin PF06954.9 001009072.1_39724001_1 - 0.072 13.5 1.1 0.21 12.0 1.1 1.7 1 0 0 1 1 1 0 Resistin Annexin PF00191.18 024156.2_45726001_2 - 3e-193 626.1 36.0 1.5e-26 92.1 1.1 8.1 8 0 0 8 8 8 8 Annexin Myb_DNA-bind_7 PF15963.3 024156.2_45726001_2 - 5.8e-05 22.8 0.3 14 5.5 0.0 6.1 6 0 0 6 6 6 1 Myb DNA-binding like RuvC PF02075.15 024156.2_45726001_2 - 0.0034 17.2 0.0 13 5.5 0.0 4.2 4 0 0 4 4 4 1 Crossover junction endodeoxyribonuclease RuvC DUF2312 PF10073.7 024156.2_45726001_2 - 0.032 13.7 11.7 25 4.5 0.1 5.7 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2312) Ribosomal_S9 PF00380.17 001137620.1_49822001_1 - 7.4e-34 116.8 0.3 8.5e-34 116.6 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 7tm_1 PF00001.19 001009125.1_39723001_1 - 6.2e-56 189.5 15.8 6.2e-56 189.5 15.8 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009125.1_39723001_1 - 6.7e-12 45.2 18.5 8.4e-12 44.9 18.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001009125.1_39723001_1 - 0.003 17.2 10.0 0.0035 17.0 4.9 2.2 2 0 0 2 2 2 1 Olfactory receptor TCTP PF00838.15 001082129.2_37923001_3 - 5.3e-82 273.9 0.4 6.5e-82 273.6 0.4 1.1 1 0 0 1 1 1 1 Translationally controlled tumour protein Insulin PF00049.16 001009774.3_39522001_3 - 9.8e-16 58.4 4.8 6.9e-13 49.3 4.8 2.8 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Glycogen_syn PF05693.11 001082023.1_37927001_1 - 0 1210.8 0.0 0 1210.5 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_4 PF13439.4 001082023.1_37927001_1 - 5.2e-07 29.7 0.2 1e-06 28.7 0.2 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_transf_5 PF08323.9 001082023.1_37927001_1 - 1.6e-05 24.6 0.3 3.4e-05 23.5 0.3 1.6 1 1 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.18 001082023.1_37927001_1 - 2.7e-05 23.7 0.1 0.001 18.6 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.4 001082023.1_37927001_1 - 0.00023 21.4 0.0 0.019 15.3 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 HEAT PF02985.20 214024.1_49825001_1 - 1e-48 158.9 25.1 0.00019 21.2 0.0 13.5 14 0 0 14 14 14 12 HEAT repeat HEAT_2 PF13646.4 214024.1_49825001_1 - 4.3e-44 148.7 5.7 1.9e-14 53.6 0.0 7.6 2 1 6 8 8 8 8 HEAT repeats Vac14_Fab1_bd PF12755.5 214024.1_49825001_1 - 1.8e-14 53.9 1.2 0.058 13.8 0.0 7.6 4 2 4 8 8 8 3 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.4 214024.1_49825001_1 - 7.8e-11 42.1 12.5 0.017 15.5 0.1 8.6 7 3 3 10 10 10 4 HEAT-like repeat Cnd1 PF12717.5 214024.1_49825001_1 - 1.2e-10 41.5 7.8 0.0055 16.6 0.4 4.7 2 1 3 5 5 5 4 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.18 214024.1_49825001_1 - 4.6e-08 31.9 5.7 0.011 14.2 0.1 4.0 1 1 1 3 3 3 3 Adaptin N terminal region CLASP_N PF12348.6 214024.1_49825001_1 - 2.5e-07 30.4 1.1 0.089 12.2 0.3 5.4 2 2 1 4 4 4 1 CLASP N terminal TAF6_C PF07571.11 214024.1_49825001_1 - 9.1e-05 22.6 0.7 0.71 10.1 0.0 4.8 4 3 1 5 5 5 1 TAF6 C-terminal HEAT repeat domain M11L PF11099.6 214024.1_49825001_1 - 0.00014 22.1 0.2 0.021 14.9 0.0 3.0 2 1 1 3 3 3 1 Apoptosis regulator M11L like IFRD PF05004.11 214024.1_49825001_1 - 0.018 14.1 1.2 1.9 7.4 0.1 3.4 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) HEAT_PBS PF03130.14 214024.1_49825001_1 - 0.094 13.3 0.0 58 4.7 0.0 4.7 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat NPA PF16469.3 214024.1_49825001_1 - 0.27 11.8 2.5 28 5.3 0.1 3.7 3 1 1 4 4 3 0 Nematode polyprotein allergen ABA-1 Mt_ATP-synt_D PF05873.10 019383.2_45722001_2 - 1.5e-64 216.3 3.5 1.9e-64 216.0 3.5 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) Homeobox PF00046.27 009123.2_32924001_1 - 7.4e-21 73.6 4.2 1.6e-20 72.6 4.2 1.6 1 0 0 1 1 1 1 Homeobox domain PDZ_1 PF12812.5 009123.2_32924001_2 - 0.14 12.1 0.1 17 5.5 0.0 2.4 1 1 1 2 2 2 0 PDZ-like domain zf-DHHC PF01529.18 001038657.1_39729001_2 - 2.5e-35 121.4 7.6 2.5e-35 121.4 7.6 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase SHMT PF00464.17 001101717.1_37925001_3 - 4.3e-211 700.5 0.0 5.1e-211 700.3 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.19 001101717.1_37925001_3 - 0.0003 19.9 0.0 0.0005 19.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.15 001101717.1_37925001_3 - 0.11 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Aldedh PF00171.20 022547.1_45727001_1 - 1e-173 578.0 0.1 1.3e-173 577.7 0.1 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Formyl_trans_N PF00551.17 022547.1_45727001_1 - 1.1e-52 178.3 0.0 3.3e-52 176.7 0.0 1.9 2 0 0 2 2 2 1 Formyl transferase Formyl_trans_C PF02911.16 022547.1_45727001_1 - 1.6e-17 63.4 0.0 3.6e-17 62.3 0.0 1.6 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain PP-binding PF00550.23 022547.1_45727001_1 - 0.00085 19.5 0.1 0.0015 18.7 0.1 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site DUF1487 PF07368.9 022547.1_45727001_1 - 0.0013 18.1 0.0 0.0029 17.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1487) Rsbr_N PF08678.8 022547.1_45727001_1 - 0.048 13.6 0.5 0.25 11.3 0.0 2.3 2 1 0 2 2 2 0 Rsbr N terminal CD47 PF04549.12 019195.2_45724001_2 - 5.8e-55 185.4 23.8 8.5e-55 184.9 23.8 1.2 1 0 0 1 1 1 1 CD47 transmembrane region V-set_CD47 PF08204.9 019195.2_45724001_2 - 1.4e-46 157.5 4.3 2e-46 157.0 4.3 1.2 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain DUF962 PF06127.9 019195.2_45724001_2 - 0.045 13.7 0.4 0.098 12.6 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF962) GPR_Gpa2_C PF11970.6 019195.2_45724001_2 - 0.11 12.4 0.1 0.27 11.2 0.1 1.7 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 C-term GHBP PF12772.5 001082636.1_37929001_1 - 1.3e-132 441.8 5.9 1.6e-132 441.4 5.9 1.1 1 0 0 1 1 1 1 Growth hormone receptor binding EpoR_lig-bind PF09067.8 001082636.1_37929001_1 - 2e-11 43.9 1.1 4.7e-11 42.7 1.1 1.6 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 001082636.1_37929001_1 - 8.6e-07 29.1 0.3 1.6e-06 28.3 0.3 1.4 1 0 0 1 1 1 1 Fibronectin type III domain Aconitase PF00330.18 213954.1_49826001_3 - 1.5e-155 518.5 0.0 1.9e-155 518.2 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.17 213954.1_49826001_3 - 4.5e-46 156.3 0.0 8.5e-46 155.4 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain Globin PF00042.20 001111269.1_45722001_2 - 5.3e-32 110.5 0.0 8.6e-32 109.8 0.0 1.3 1 0 0 1 1 1 1 Globin ApoA-II PF04711.11 001008976.1_39721001_1 - 3e-41 139.3 1.0 3.5e-41 139.1 1.0 1.1 1 0 0 1 1 1 1 Apolipoprotein A-II (ApoA-II) KNOX2 PF03791.11 001008976.1_39721001_1 - 0.051 13.1 0.1 0.1 12.1 0.1 1.4 1 0 0 1 1 1 0 KNOX2 domain Hrs_helical PF12210.6 001008976.1_39721001_1 - 0.11 12.9 0.0 0.15 12.5 0.0 1.2 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Guanylate_kin PF00625.19 012828.2_45726001_3 - 1.2e-45 155.3 0.3 1.9e-45 154.6 0.1 1.5 2 0 0 2 2 2 1 Guanylate kinase VGCC_beta4Aa_N PF12052.6 012828.2_45726001_3 - 2.4e-19 69.0 7.1 6.8e-19 67.6 7.1 1.9 1 0 0 1 1 1 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal SAM_2 PF07647.15 053473.2_45728001_3 - 1.4e-15 57.0 0.4 2.9e-15 56.0 0.4 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ PF00595.22 053473.2_45728001_3 - 2.7e-13 49.9 2.1 6.6e-13 48.7 2.1 1.7 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SAM_1 PF00536.28 053473.2_45728001_3 - 2.9e-11 43.5 0.6 6e-11 42.5 0.6 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ_2 PF13180.4 053473.2_45728001_3 - 0.0011 19.1 0.7 0.0069 16.5 0.4 2.4 2 0 0 2 2 2 1 PDZ domain SAM_PNT PF02198.14 053473.2_45728001_3 - 0.053 13.4 0.1 0.16 11.9 0.1 1.7 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Peptidase_M99_C PF17129.2 053473.2_45728001_3 - 0.096 12.8 0.4 1.2 9.2 0.0 2.8 2 0 0 2 2 2 0 C-terminal domain of metallo-carboxypeptidase DUF2278 PF10042.7 053473.2_45728001_3 - 1.2 8.9 5.7 0.43 10.4 2.2 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2278) 7tm_4 PF13853.4 001009879.1_39722001_1 - 3.4e-59 200.7 20.1 4e-59 200.5 20.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001009879.1_39722001_1 - 6.2e-24 84.5 23.3 3e-23 82.3 23.3 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009879.1_39722001_1 - 1.7e-05 24.2 17.8 3.1e-05 23.4 17.8 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001009879.1_39722001_1 - 0.036 13.2 17.3 0.1 11.7 17.3 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx HCO3_cotransp PF00955.19 001081766.1_21029001_3 - 7.6e-213 707.9 1.8 1e-212 707.4 1.8 1.2 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 001081766.1_21029001_3 - 9.2e-106 353.4 0.1 1.4e-105 352.9 0.1 1.2 1 0 0 1 1 1 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.20 001081766.1_21029001_3 - 0.00018 21.3 0.0 0.00032 20.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Cytochrom_B_C PF00032.15 001081766.1_21029001_3 - 4 7.7 5.8 3 8.1 0.2 3.1 3 1 0 3 3 3 0 Cytochrome b(C-terminal)/b6/petD cNMP_binding PF00027.27 214026.1_49823001_3 - 7.6e-41 137.9 0.0 2.2e-20 72.3 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.15 214026.1_49823001_3 - 5.6e-16 57.8 0.2 1.2e-15 56.8 0.2 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Cupin_2 PF07883.9 214026.1_49823001_3 - 0.18 11.4 1.6 5.5 6.6 0.1 2.3 2 0 0 2 2 2 0 Cupin domain Amino_oxidase PF01593.22 001001640.1_49824001_1 - 3.1e-74 250.8 0.0 3.6e-74 250.5 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 001001640.1_49824001_1 - 3.1e-14 52.8 0.1 7.5e-14 51.6 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.17 001001640.1_49824001_1 - 4.2e-07 29.4 0.3 6.5e-07 28.8 0.3 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.22 001001640.1_49824001_1 - 5.1e-07 29.5 0.1 9.1e-07 28.7 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 001001640.1_49824001_1 - 1.1e-05 24.6 0.5 1.5e-05 24.1 0.5 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.12 001001640.1_49824001_1 - 1.8e-05 24.0 0.3 3.7e-05 23.0 0.2 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.15 001001640.1_49824001_1 - 2.3e-05 23.6 0.2 3.7e-05 23.0 0.2 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.25 001001640.1_49824001_1 - 2.7e-05 24.5 0.4 5.8e-05 23.4 0.4 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.5 001001640.1_49824001_1 - 6.8e-05 22.3 0.2 0.0001 21.7 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.12 001001640.1_49824001_1 - 0.00011 20.9 0.1 0.00045 18.9 0.2 1.8 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.4 001001640.1_49824001_1 - 0.00049 19.3 0.0 0.11 11.5 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.10 001001640.1_49824001_1 - 0.00059 18.9 0.2 0.00087 18.3 0.2 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.19 001001640.1_49824001_1 - 0.00072 18.8 0.2 0.0012 18.1 0.2 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.20 001001640.1_49824001_1 - 0.0069 15.4 1.3 0.014 14.4 0.0 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A Trp_halogenase PF04820.12 001001640.1_49824001_1 - 0.16 10.6 1.3 0.16 10.6 0.2 1.5 2 0 0 2 2 2 0 Tryptophan halogenase TrkA_N PF02254.16 001001640.1_49824001_1 - 0.2 11.8 0.6 1 9.5 0.4 2.1 2 0 0 2 2 2 0 TrkA-N domain An_peroxidase PF03098.13 001082388.1_37927001_1 - 8.7e-53 179.5 0.0 3.3e-45 154.5 0.0 2.2 1 1 1 2 2 2 2 Animal haem peroxidase EGF PF00008.25 001082388.1_37927001_1 - 0.00014 21.9 12.2 0.00032 20.8 12.2 1.6 1 0 0 1 1 1 1 EGF-like domain DnaJ PF00226.29 024161.2_45722001_1 - 3e-27 94.4 2.7 4.6e-27 93.8 2.7 1.3 1 0 0 1 1 1 1 DnaJ domain Baculo_F PF12259.6 024161.2_45722001_1 - 0.022 13.2 0.0 0.027 12.9 0.0 1.1 1 0 0 1 1 1 0 Baculovirus F protein EMP70 PF02990.14 024161.2_45722001_1 - 0.04 12.4 0.3 0.054 12.0 0.3 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 Defensin_beta PF00711.17 001009151.1_39721001_1 - 1.8e-12 46.9 8.9 2.5e-12 46.5 8.9 1.2 1 0 0 1 1 1 1 Beta defensin Ribosomal_S4e PF00900.18 001008987.1_39722001_3 - 5.6e-38 128.6 1.2 1.5e-37 127.2 0.9 1.8 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.3 001008987.1_39722001_3 - 4.7e-28 96.5 0.1 8.3e-28 95.7 0.1 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.10 001008987.1_39722001_3 - 4e-22 77.9 6.2 8.4e-22 76.9 6.2 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain KOW PF00467.27 001008987.1_39722001_3 - 2.4e-05 24.0 0.4 2.4e-05 24.0 0.4 2.3 2 0 0 2 2 2 1 KOW motif S4 PF01479.23 001008987.1_39722001_3 - 9.8e-05 21.8 0.0 0.00019 20.9 0.0 1.5 1 0 0 1 1 1 1 S4 domain zf-FCS PF06467.12 001039650.2_26224001_2 - 7.4e-09 35.3 11.3 2.4e-07 30.5 2.0 3.5 3 0 0 3 3 3 2 MYM-type Zinc finger with FCS sequence motif YHS PF04945.11 001039650.2_26224001_2 - 0.0051 16.8 1.3 0.0085 16.0 0.6 1.7 2 0 0 2 2 2 1 YHS domain zf-FLZ PF04570.12 001039650.2_26224001_2 - 0.018 14.4 0.3 0.018 14.4 0.3 1.9 2 0 0 2 2 2 0 zinc-finger of the FCS-type, C2-C2 PLATZ PF04640.12 001039650.2_26224001_2 - 1.8 9.1 5.6 0.43 11.1 0.7 2.5 2 0 0 2 2 2 0 PLATZ transcription factor zf-HIT PF04438.14 001039650.2_26224001_2 - 2.5 7.9 6.3 1.2 8.9 2.0 2.5 2 0 0 2 2 2 0 HIT zinc finger BACK PF07707.13 172565.2_32925001_1 - 2.7e-25 88.3 3.8 4.1e-25 87.7 2.1 2.1 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.29 172565.2_32925001_1 - 6.2e-23 81.0 0.0 1.6e-22 79.7 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.4 172565.2_32925001_1 - 4.7e-20 71.0 2.7 7.3e-05 22.8 0.0 5.0 4 1 1 5 5 5 4 Kelch motif Kelch_1 PF01344.23 172565.2_32925001_1 - 8.1e-17 60.4 8.6 7.6e-05 22.1 0.0 5.8 5 1 0 5 5 5 4 Kelch motif Kelch_4 PF13418.4 172565.2_32925001_1 - 2.5e-09 36.8 0.2 0.16 11.8 0.0 5.3 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.13 172565.2_32925001_1 - 8.1e-09 35.0 4.5 0.0023 17.7 0.1 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.4 172565.2_32925001_1 - 5.1e-07 29.7 0.1 0.029 14.5 0.0 4.9 5 0 0 5 5 5 1 Galactose oxidase, central domain DUF3342 PF11822.6 172565.2_32925001_1 - 0.045 13.8 0.0 0.44 10.6 0.0 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) SK_channel PF03530.12 019315.2_45726001_1 - 2.8e-48 162.5 0.5 2.8e-48 162.5 0.5 2.3 2 0 0 2 2 2 1 Calcium-activated SK potassium channel CaMBD PF02888.14 019315.2_45726001_1 - 2.2e-38 130.2 8.9 2.2e-38 130.2 8.9 2.2 2 0 0 2 2 2 1 Calmodulin binding domain Ion_trans_2 PF07885.14 019315.2_45726001_1 - 9.7e-13 47.8 3.1 9.7e-13 47.8 3.1 2.2 2 0 0 2 2 2 1 Ion channel SARAF PF06682.10 019315.2_45726001_1 - 0.021 14.4 3.1 0.042 13.4 3.1 1.4 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF2360 PF10152.7 019315.2_45726001_1 - 0.069 13.4 7.0 0.35 11.1 3.8 2.8 3 0 0 3 3 3 0 Predicted coiled-coil domain-containing protein (DUF2360) Spt20 PF12090.6 019315.2_45726001_1 - 2.3 7.7 20.2 4.9 6.5 20.2 1.5 1 0 0 1 1 1 0 Spt20 family PMP1_2 PF08114.9 019315.2_45726001_1 - 5.4 6.7 6.1 15 5.3 0.3 2.8 2 0 0 2 2 2 0 ATPase proteolipid family Cathelicidins PF00666.15 001071815.1_39722001_1 - 1.6e-51 172.7 0.2 2e-51 172.4 0.2 1.1 1 0 0 1 1 1 1 Cathelicidin CAP18_C PF12153.6 001071815.1_39722001_1 - 9.2e-10 38.2 10.4 1.3e-09 37.7 10.4 1.2 1 0 0 1 1 1 1 LPS binding domain of CAP18 (C terminal) Spp-24 PF07448.9 001071815.1_39722001_1 - 3.5e-05 23.8 0.3 6e-05 23.0 0.3 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Defensin_beta_2 PF13841.4 001129759.1_39721001_1 - 8.7e-05 22.8 7.7 0.00012 22.4 7.7 1.2 1 0 0 1 1 1 1 Beta defensin Defensin_beta PF00711.17 001129759.1_39721001_1 - 0.00022 21.0 7.5 0.0003 20.6 7.5 1.2 1 0 0 1 1 1 1 Beta defensin 7tm_4 PF13853.4 001009114.1_39722001_1 - 1.9e-51 175.3 28.3 2.2e-51 175.1 28.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001009114.1_39722001_1 - 3.4e-25 88.7 33.2 8e-25 87.4 33.2 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009114.1_39722001_1 - 6.9e-05 22.2 26.4 7.9e-05 22.0 25.0 1.8 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001009114.1_39722001_1 - 0.25 10.5 30.5 0.49 9.5 30.5 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx SMAP PF15477.4 001132637.1_43525001_3 - 9e-17 61.7 1.6 9e-17 61.7 1.6 3.6 2 1 0 2 2 2 1 Small acidic protein family CLASP_N PF12348.6 053722.2_45729001_3 - 1.9e-43 148.6 8.5 3e-39 134.8 0.1 3.2 3 0 0 3 3 3 2 CLASP N terminal HEAT PF02985.20 053722.2_45729001_3 - 5.9e-09 35.3 7.5 0.11 12.6 0.0 7.7 9 0 0 9 9 8 2 HEAT repeat HEAT_EZ PF13513.4 053722.2_45729001_3 - 1.8e-06 28.1 0.1 0.019 15.3 0.0 4.5 4 0 0 4 4 4 1 HEAT-like repeat RTP1_C1 PF10363.7 053722.2_45729001_3 - 4.1e-06 26.8 2.5 0.053 13.6 0.2 3.6 3 1 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.5 053722.2_45729001_3 - 0.0015 18.5 6.0 0.0063 16.4 0.9 3.9 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 TFCD_C PF12612.6 053722.2_45729001_3 - 0.0036 17.1 0.2 0.059 13.1 0.1 2.8 3 0 0 3 3 3 1 Tubulin folding cofactor D C terminal Ipi1_N PF12333.6 053722.2_45729001_3 - 0.0059 17.1 1.0 0.88 10.1 0.0 3.5 3 0 0 3 3 3 1 Rix1 complex component involved in 60S ribosome maturation MMS19_N PF14500.4 053722.2_45729001_3 - 0.0099 15.3 3.0 9.4 5.6 0.1 3.5 3 1 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II TAN PF11640.6 053722.2_45729001_3 - 0.011 15.7 3.2 0.13 12.3 0.1 3.8 3 1 1 4 4 4 0 Telomere-length maintenance and DNA damage repair ParcG PF10274.7 053722.2_45729001_3 - 0.033 14.2 0.2 0.15 12.0 0.1 2.1 2 0 0 2 2 2 0 Parkin co-regulated protein MMS19_C PF12460.6 053722.2_45729001_3 - 0.044 12.8 7.1 0.23 10.4 0.7 3.1 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.5 053722.2_45729001_3 - 0.12 12.8 0.3 35 4.9 0.0 3.7 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Telomere_reg-2 PF10193.7 053722.2_45729001_3 - 9.5 6.6 6.0 2.6 8.4 0.2 3.1 3 1 2 5 5 5 0 Telomere length regulation protein Ras PF00071.20 001031787.1_49822001_1 - 5.5e-67 224.3 0.8 6.5e-67 224.0 0.8 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001031787.1_49822001_1 - 5.4e-37 126.6 0.1 9.6e-37 125.7 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001031787.1_49822001_1 - 5.6e-17 61.6 0.1 6.6e-17 61.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 001031787.1_49822001_1 - 8.8e-07 28.8 0.4 0.013 15.3 0.1 2.2 1 1 1 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001031787.1_49822001_1 - 4.7e-06 26.1 0.3 1.2e-05 24.8 0.3 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001031787.1_49822001_1 - 1.7e-05 24.7 0.1 5.3e-05 23.1 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001031787.1_49822001_1 - 2.6e-05 23.6 0.1 3.5e-05 23.2 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001031787.1_49822001_1 - 3.5e-05 23.2 0.1 5.3e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.27 001031787.1_49822001_1 - 0.00077 19.8 0.1 0.09 13.1 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.16 001031787.1_49822001_1 - 0.0045 16.4 0.0 0.028 13.8 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.4 001031787.1_49822001_1 - 0.016 15.4 0.0 0.025 14.8 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 001031787.1_49822001_1 - 0.048 13.8 0.0 0.086 13.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.4 001031787.1_49822001_1 - 0.051 13.2 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain PduV-EutP PF10662.7 001031787.1_49822001_1 - 0.06 13.0 0.1 0.8 9.3 0.0 2.2 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.12 001031787.1_49822001_1 - 0.074 12.9 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Septin PF00735.16 001031787.1_49822001_1 - 0.081 12.0 0.0 0.19 10.8 0.0 1.6 1 0 0 1 1 1 0 Septin ABC_tran PF00005.25 001031787.1_49822001_1 - 0.084 13.3 0.0 0.13 12.7 0.0 1.5 1 1 0 1 1 1 0 ABC transporter Sp38 PF07354.10 199321.2_26225001_1 - 9.9e-145 480.3 5.6 1.3e-144 479.9 5.6 1.1 1 0 0 1 1 1 1 Zona-pellucida-binding protein (Sp38) NTP_transferase PF00483.21 133609.2_45724001_1 - 6.2e-17 61.9 0.0 1.7e-16 60.4 0.0 1.7 2 0 0 2 2 2 1 Nucleotidyl transferase NTP_transf_3 PF12804.5 133609.2_45724001_1 - 1.5e-15 57.7 0.0 2.1e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.22 133609.2_45724001_1 - 5.3e-07 29.0 8.1 0.028 14.0 3.6 4.5 1 1 2 3 3 3 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.3 133609.2_45724001_1 - 7.5e-05 20.9 1.4 0.00011 20.4 1.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) CTP_transf_3 PF02348.17 133609.2_45724001_1 - 0.012 15.4 0.2 0.057 13.2 0.0 1.9 2 0 0 2 2 2 0 Cytidylyltransferase Fucokinase PF07959.10 133609.2_45724001_1 - 0.015 14.2 1.7 0.028 13.3 1.7 1.4 1 0 0 1 1 1 0 L-fucokinase DEK_C PF08766.9 001004255.1_45726001_1 - 1.8e-17 62.8 0.6 4e-17 61.7 0.6 1.6 1 0 0 1 1 1 1 DEK C terminal domain SAP PF02037.25 001004255.1_45726001_1 - 5.6e-05 22.7 0.2 5.6e-05 22.7 0.2 2.0 2 0 0 2 2 2 1 SAP domain Mem_trans PF03547.16 001004255.1_45726001_1 - 0.021 13.1 0.1 0.03 12.6 0.1 1.4 1 0 0 1 1 1 0 Membrane transport protein MIP-T3 PF10243.7 001004255.1_45726001_1 - 0.97 7.9 53.7 0.044 12.4 37.5 2.1 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 DUF2052 PF09747.7 001004255.1_45726001_1 - 1.6 8.7 32.9 4.2 7.3 5.3 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) ORC6 PF05460.11 001004255.1_45726001_1 - 2 7.5 34.9 0.36 9.9 26.1 2.1 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) BAG PF02179.14 001008526.2_45725001_3 - 9.5e-49 163.6 20.5 7.9e-15 54.9 0.1 5.1 5 0 0 5 5 5 4 BAG domain DUF327 PF03885.11 001008526.2_45725001_3 - 0.41 10.5 5.5 0.25 11.1 0.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF327) DUF2682 PF10909.6 001008526.2_45725001_3 - 5.9 7.3 6.2 16 6.0 0.1 3.4 4 1 0 4 4 4 0 Protein of unknown function (DUF2682) DRY_EERY PF09750.7 001024294.1_45725001_1 - 7.9e-43 145.8 0.0 7.9e-43 145.8 0.0 3.8 4 1 0 4 4 4 1 Alternative splicing regulator S-antigen PF05756.9 001024294.1_45725001_1 - 0.17 12.0 2.5 0.47 10.6 2.5 1.8 1 0 0 1 1 1 0 S-antigen protein Trypan_PARP PF05887.9 001024294.1_45725001_3 - 0.091 12.7 14.3 0.28 11.1 14.3 1.7 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) GTP_EFTU PF00009.25 001081781.1_21024001_3 - 2.8e-54 183.5 0.0 4e-54 183.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 001081781.1_21024001_3 - 2.8e-38 130.5 0.0 5.9e-38 129.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.23 001081781.1_21024001_3 - 7.9e-15 54.9 2.2 8.6e-15 54.8 0.7 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 001081781.1_21024001_3 - 0.00037 20.4 0.2 0.01 15.8 0.2 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.4 001081781.1_21024001_3 - 0.0087 15.9 1.6 0.017 15.0 0.3 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 4 Dynamin_N PF00350.21 001081781.1_21024001_3 - 0.13 12.2 0.1 20 5.1 0.1 2.4 2 0 0 2 2 2 0 Dynamin family G-alpha PF00503.18 001081781.1_21024001_3 - 0.15 11.1 0.1 0.44 9.5 0.0 1.7 2 0 0 2 2 2 0 G-protein alpha subunit Phosphorylase PF00343.18 001024861.1_39527001_2 - 0 1143.3 0.0 0 1143.1 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase Myotub-related PF06602.12 001013047.1_45726001_1 - 1.9e-143 477.4 0.0 2.7e-143 476.9 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.18 001013047.1_45726001_1 - 1.6e-17 63.3 0.0 2.7e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 GRAM domain DSPc PF00782.18 001013047.1_45726001_1 - 0.00062 19.5 0.0 0.0013 18.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain 3-PAP PF12578.6 001013047.1_45726001_1 - 0.0035 16.9 0.2 0.0068 16.0 0.2 1.4 1 0 0 1 1 1 1 Myotubularin-associated protein Y_phosphatase PF00102.25 001013047.1_45726001_1 - 0.0078 15.7 0.0 0.019 14.4 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 001013047.1_45726001_1 - 0.062 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Pkinase PF00069.23 002732.3_26224001_2 - 8.9e-72 241.5 0.0 1.1e-71 241.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 002732.3_26224001_2 - 2.6e-35 121.8 0.0 3.5e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 002732.3_26224001_2 - 1.6e-10 40.7 0.1 3.6e-10 39.5 0.1 1.6 1 1 1 2 2 2 1 Kinase-like APH PF01636.21 002732.3_26224001_2 - 0.00016 21.5 0.0 0.055 13.2 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.12 002732.3_26224001_2 - 0.014 14.6 0.2 0.075 12.2 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 002732.3_26224001_2 - 0.049 13.1 0.1 0.084 12.3 0.1 1.3 1 0 0 1 1 1 0 RIO1 family SHMT PF00464.17 001009469.1_39523001_3 - 3.6e-210 697.4 0.0 4.2e-210 697.2 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.15 001009469.1_39523001_3 - 0.0058 15.9 0.0 0.0093 15.2 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Secretogranin_V PF05281.9 001098549.1_39723001_1 - 2.1e-11 43.8 0.3 1.3e-08 34.6 0.1 2.1 1 1 1 2 2 2 2 Neuroendocrine protein 7B2 precursor (Secretogranin V) Ald_Xan_dh_C2 PF02738.16 019363.3_45729001_1 - 2.9e-184 613.4 0.1 3.9e-184 613.0 0.1 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 019363.3_45729001_1 - 7.4e-43 146.1 0.0 2.1e-42 144.6 0.0 1.8 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 019363.3_45729001_1 - 4.8e-33 113.7 0.4 8.3e-33 112.9 0.4 1.4 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.15 019363.3_45729001_1 - 7.1e-30 103.1 0.0 2.2e-29 101.5 0.0 1.9 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.18 019363.3_45729001_1 - 4.3e-29 100.1 0.6 1.1e-28 98.9 0.6 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.25 019363.3_45729001_1 - 2.1e-08 33.9 0.1 2.1e-08 33.9 0.1 3.0 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain Annexin PF00191.18 013132.1_45723001_3 - 2.4e-94 309.3 8.4 1.6e-23 82.4 0.2 4.1 4 0 0 4 4 4 4 Annexin DUF2312 PF10073.7 013132.1_45723001_3 - 0.092 12.3 0.1 3.7 7.1 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2312) ELFV_dehydrog_N PF02812.16 001009004.1_39724001_1 - 6.6e-62 207.0 0.0 1.3e-61 206.0 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.19 001009004.1_39724001_1 - 7.8e-55 186.1 0.0 1.9e-51 175.0 0.0 2.2 2 0 0 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 2-Hacid_dh_C PF02826.17 001009004.1_39724001_1 - 0.021 14.1 0.0 0.045 13.0 0.0 1.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SF3b10 PF07189.9 001009004.1_39724001_1 - 0.058 13.4 0.0 1.3 9.0 0.0 2.8 3 0 0 3 3 3 0 Splicing factor 3B subunit 10 (SF3b10) Ifi-6-16 PF06140.11 001009069.1_39722001_3 - 2.3e-18 65.7 19.8 4.7e-18 64.7 19.8 1.5 1 0 0 1 1 1 1 Interferon-induced 6-16 family Ribosomal_L29 PF00831.21 212511.2_45721001_1 - 1.8e-20 72.5 2.2 1.8e-20 72.5 2.2 2.5 2 1 1 3 3 3 1 Ribosomal L29 protein GTP_EFTU PF00009.25 001082339.1_37924001_2 - 2.7e-54 183.5 0.0 3.9e-54 183.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 001082339.1_37924001_2 - 9.3e-40 135.3 0.0 2e-39 134.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.23 001082339.1_37924001_2 - 7.6e-15 54.9 2.2 8.4e-15 54.8 0.7 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 001082339.1_37924001_2 - 0.00041 20.3 0.2 0.0098 15.8 0.2 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.4 001082339.1_37924001_2 - 0.0093 15.8 1.8 0.017 15.0 0.3 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 4 G-alpha PF00503.18 001082339.1_37924001_2 - 0.11 11.5 0.1 0.31 10.0 0.0 1.7 2 0 0 2 2 2 0 G-protein alpha subunit Dynamin_N PF00350.21 001082339.1_37924001_2 - 0.12 12.3 0.1 20 5.1 0.1 2.4 2 0 0 2 2 2 0 Dynamin family Pyridoxal_deC PF00282.17 001009225.1_22425001_1 - 4e-152 506.2 0.0 5e-152 505.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 001009225.1_22425001_1 - 8.3e-06 24.8 0.0 9.8e-05 21.3 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.19 001009225.1_22425001_1 - 2.4e-05 23.6 0.0 5.5e-05 22.5 0.0 1.5 2 0 0 2 2 2 1 Beta-eliminating lyase SepSecS PF05889.11 001009225.1_22425001_1 - 0.013 14.1 0.0 0.02 13.4 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS DegT_DnrJ_EryC1 PF01041.15 001009225.1_22425001_1 - 0.015 14.5 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family OKR_DC_1 PF01276.18 001009225.1_22425001_1 - 0.032 12.8 0.0 0.05 12.2 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Pkinase PF00069.23 001009234.1_39524001_2 - 1.1e-72 244.4 0.0 1.4e-72 244.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001009234.1_39524001_2 - 1.1e-33 116.5 0.0 1.5e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001009234.1_39524001_2 - 1.7e-08 34.0 0.1 4.6e-08 32.6 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.21 001009234.1_39524001_2 - 0.12 12.2 0.0 2.5 7.8 0.0 2.1 1 1 0 2 2 2 0 Phosphotransferase enzyme family Proteasome PF00227.24 057099.3_45722001_3 - 4.2e-46 156.7 0.2 4.9e-46 156.5 0.2 1.0 1 0 0 1 1 1 1 Proteasome subunit Aminotran_5 PF00266.17 001082271.1_37925001_2 - 1.1e-74 251.5 0.0 1.3e-74 251.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Anoctamin PF04547.10 001004071.1_45726001_2 - 7.1e-160 532.4 7.7 9e-160 532.1 7.7 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.3 001004071.1_45726001_2 - 2.9e-62 210.2 0.0 4.3e-62 209.7 0.0 1.2 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin DUF2207 PF09972.7 001004071.1_45726001_2 - 2.5 6.7 8.8 2.8 6.5 0.4 2.6 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) p450 PF00067.20 214394.1_49824001_3 - 1.3e-132 442.7 0.0 1.5e-132 442.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 A_deaminase PF00962.20 001101681.2_45727001_1 - 2e-134 448.0 1.0 3.6e-134 447.1 1.0 1.4 1 1 0 1 1 1 1 Adenosine/AMP deaminase RRM_1 PF00076.20 133400.1_45724001_1 - 2.9e-40 135.8 0.8 5.7e-17 61.2 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DND1_DSRM PF14709.5 133400.1_45724001_1 - 3.7e-26 91.1 0.1 9e-26 89.8 0.1 1.7 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 RRM_7 PF16367.3 133400.1_45724001_1 - 5e-05 23.2 0.1 0.27 11.2 0.0 3.1 3 1 0 3 3 3 2 RNA recognition motif RRM_5 PF13893.4 133400.1_45724001_1 - 6.5e-05 22.4 0.2 0.15 11.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.4 133400.1_45724001_1 - 9.8e-05 22.5 0.2 0.48 10.5 0.0 3.6 3 1 0 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter Limkain-b1 PF11608.6 133400.1_45724001_1 - 0.00024 21.0 0.1 0.28 11.2 0.0 2.9 3 0 0 3 3 3 2 Limkain b1 BRAP2 PF07576.10 133400.1_45724001_1 - 0.0068 16.5 0.1 0.095 12.8 0.0 2.6 3 0 0 3 3 3 1 BRCA1-associated protein 2 RRM_occluded PF16842.3 133400.1_45724001_1 - 0.0083 15.8 0.1 7.1 6.4 0.0 2.9 3 0 0 3 3 3 2 Occluded RNA-recognition motif dsrm PF00035.24 133400.1_45724001_1 - 0.011 16.3 1.3 0.78 10.3 0.3 3.4 2 1 0 2 2 2 0 Double-stranded RNA binding motif SET_assoc PF11767.6 133400.1_45724001_1 - 0.074 12.6 0.1 8.1 6.0 0.1 2.4 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated Nup35_RRM_2 PF14605.4 133400.1_45724001_1 - 0.097 12.5 1.0 14 5.6 0.0 2.9 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Casein PF00363.16 001082391.1_37923001_2 - 1.5e-21 76.7 13.8 1.5e-21 76.7 13.8 1.7 2 0 0 2 2 2 1 Casein PGK PF00162.17 213782.1_49824001_1 - 1.5e-149 497.9 0.1 1.8e-149 497.7 0.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase SR-25 PF10500.7 001001734.1_26222001_2 - 0.55 9.7 17.6 0.7 9.3 17.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4705 PF15788.3 001001734.1_26222001_2 - 8.1 6.6 11.1 0.3 11.2 3.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4705) Cation_ATPase_C PF00689.19 001001734.1_26222001_3 - 1.1e-23 83.7 2.0 1.4e-23 83.4 2.0 1.1 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Na_Pi_cotrans PF02690.13 001082673.2_37925001_3 - 4e-41 140.3 17.9 2e-24 86.2 6.7 2.4 2 0 0 2 2 2 2 Na+/Pi-cotransporter Ferritin PF00210.22 001114540.1_21022001_1 - 5.9e-29 100.7 0.7 7e-29 100.5 0.7 1.1 1 0 0 1 1 1 1 Ferritin-like domain Carn_acyltransf PF00755.18 001145134.1_26226001_1 - 1.1e-185 618.6 0.0 1.4e-185 618.2 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CPT_N PF16484.3 001145134.1_26226001_1 - 1.6e-26 91.9 0.1 3.5e-26 90.8 0.1 1.6 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus DUF3128 PF11326.6 001145134.1_26226001_1 - 0.048 13.9 0.1 0.26 11.5 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3128) Pribosyltran PF00156.25 001013061.1_45722001_1 - 8.9e-25 86.9 0.0 1e-24 86.7 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.4 001013061.1_45722001_1 - 0.00059 19.2 0.0 0.00074 18.9 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.4 001013061.1_45722001_1 - 0.00078 18.9 0.0 0.0011 18.3 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase ASC PF00858.22 001034014.1_45726001_1 - 1.1e-99 334.0 0.1 1.4e-99 333.7 0.1 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Pkinase PF00069.23 001100922.1_45725001_2 - 4.6e-72 242.4 0.0 5.8e-72 242.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001100922.1_45725001_2 - 1.8e-33 115.8 0.0 2.4e-33 115.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001100922.1_45725001_2 - 5e-08 32.5 0.0 6.7e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Glyco_hydro_59 PF02057.13 001044262.2_29629001_1 - 0 1586.2 12.0 0 1585.9 12.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Pkinase PF00069.23 001082274.1_37926001_2 - 2e-65 220.6 0.0 2.8e-65 220.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001082274.1_37926001_2 - 4e-37 127.8 0.0 7.1e-37 127.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 001082274.1_37926001_2 - 1.2e-30 104.9 26.1 1.9e-16 59.6 5.0 3.1 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C2 PF00168.28 001082274.1_37926001_2 - 9.4e-13 48.2 0.0 1.7e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 C2 domain Pkinase_C PF00433.22 001082274.1_37926001_2 - 7.5e-09 36.0 0.1 1.6e-08 35.0 0.1 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain FTA2 PF13095.4 001082274.1_37926001_2 - 0.0031 17.1 0.1 0.32 10.5 0.0 2.4 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.4 001082274.1_37926001_2 - 0.011 15.0 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.12 001082274.1_37926001_2 - 0.037 13.2 0.0 0.062 12.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PP_M1 PF03012.12 001082274.1_37926001_2 - 0.18 11.2 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 Phosphoprotein C1_2 PF03107.14 001082274.1_37926001_2 - 0.29 11.3 16.1 1.7 8.9 2.1 2.8 2 0 0 2 2 2 0 C1 domain PHD_4 PF16866.3 001082274.1_37926001_2 - 0.33 11.0 7.2 2.8 8.0 0.3 2.8 2 0 0 2 2 2 0 PHD-finger Zf_RING PF16744.3 001082274.1_37926001_2 - 0.51 10.3 12.9 1.3 9.1 3.8 2.6 2 0 0 2 2 2 0 KIAA1045 RING finger FYVE_2 PF02318.14 001082274.1_37926001_2 - 2.7 8.1 11.8 5 7.2 2.1 2.7 2 0 0 2 2 2 0 FYVE-type zinc finger Pkinase PF00069.23 001082273.1_37925001_2 - 1e-60 205.2 0.0 1.5e-60 204.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain C1_1 PF00130.20 001082273.1_37925001_2 - 7.7e-34 115.2 25.2 1.4e-17 63.2 9.4 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_Tyr PF07714.15 001082273.1_37925001_2 - 2.9e-32 111.9 0.0 4.9e-32 111.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C2 PF00168.28 001082273.1_37925001_2 - 3.9e-28 97.6 0.0 6.1e-28 97.0 0.0 1.3 1 0 0 1 1 1 1 C2 domain Pkinase_C PF00433.22 001082273.1_37925001_2 - 1.6e-06 28.5 0.3 4.6e-06 27.1 0.3 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain PHD_4 PF16866.3 001082273.1_37925001_2 - 0.066 13.2 10.5 2.5 8.1 3.4 3.1 3 0 0 3 3 3 0 PHD-finger Kinase-like PF14531.4 001082273.1_37925001_2 - 0.07 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.21 001082273.1_37925001_2 - 0.11 12.3 0.0 0.29 10.9 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family C1_2 PF03107.14 001082273.1_37925001_2 - 0.14 12.4 21.0 1.3 9.3 4.1 2.6 2 0 0 2 2 2 0 C1 domain TAS2R PF05296.11 001009140.1_39722001_1 - 4.2e-68 229.5 25.8 5.3e-68 229.2 25.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TPMT PF05724.9 001035519.1_39722001_1 - 9e-86 286.9 0.0 1e-85 286.7 0.0 1.0 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_25 PF13649.4 001035519.1_39722001_1 - 0.0042 17.6 0.0 0.05 14.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001035519.1_39722001_1 - 0.023 15.2 0.0 0.075 13.5 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain His_Phos_1 PF00300.20 001082269.2_37924001_1 - 1.8e-32 112.5 0.0 4.9e-25 88.2 0.1 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Exc PF07825.9 001082269.2_37924001_1 - 0.071 13.0 0.1 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 Excisionase-like protein Aldedh PF00171.20 001131237.2_43525001_3 - 3.8e-85 286.0 0.0 5.1e-85 285.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.12 001131237.2_43525001_3 - 0.00056 18.9 0.0 0.00097 18.1 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) PT-HINT PF07591.9 001131237.2_43525001_3 - 0.077 13.1 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Pretoxin HINT domain CD4-extracel PF09191.8 001009043.1_39724001_2 - 1.9e-46 156.8 0.8 1.9e-46 156.8 0.8 3.5 4 0 0 4 4 4 1 CD4, extracellular C2-set PF05790.13 001009043.1_39724001_2 - 4.3e-40 135.6 12.7 8.9e-21 73.7 0.8 4.2 4 0 0 4 4 4 2 Immunoglobulin C2-set domain ig PF00047.23 001009043.1_39724001_2 - 8.1e-23 80.3 4.6 1.9e-17 63.0 0.2 4.0 4 1 0 4 4 4 2 Immunoglobulin domain Tcell_CD4_C PF12104.6 001009043.1_39724001_2 - 5.3e-17 61.3 10.8 5.3e-17 61.3 10.8 2.2 2 0 0 2 2 1 1 T cell CD4 receptor C terminal region V-set PF07686.15 001009043.1_39724001_2 - 2.4e-15 56.5 0.2 5.8e-11 42.4 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.14 001009043.1_39724001_2 - 7.6e-13 48.2 1.3 1.7e-07 31.1 0.3 3.8 4 1 0 4 4 4 2 Immunoglobulin I-set domain Ig_3 PF13927.4 001009043.1_39724001_2 - 7.4e-12 45.6 3.3 4.7e-07 30.2 0.1 3.5 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 001009043.1_39724001_2 - 6.3e-10 39.1 3.3 0.00033 20.8 0.2 4.2 3 1 0 3 3 3 2 Immunoglobulin domain Receptor_2B4 PF11465.6 001009043.1_39724001_2 - 7.2e-07 29.2 0.4 2.1e-05 24.5 0.3 2.8 2 0 0 2 2 2 1 Natural killer cell receptor 2B4 Ig_5 PF16681.3 001009043.1_39724001_2 - 0.00038 20.7 0.9 0.61 10.4 1.0 3.5 2 1 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 001009043.1_39724001_2 - 0.0035 17.2 0.1 3.2 7.7 0.0 3.5 3 1 1 4 4 4 1 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.9 001009043.1_39724001_2 - 0.017 15.0 0.1 12 5.7 0.0 2.9 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain Herpes_gE PF02480.14 001009043.1_39724001_2 - 0.054 12.1 0.2 0.39 9.3 0.1 2.1 3 0 0 3 3 3 0 Alphaherpesvirus glycoprotein E P_proprotein PF01483.18 001009043.1_39724001_2 - 0.089 12.7 0.2 0.31 11.0 0.1 2.0 2 0 0 2 2 2 0 Proprotein convertase P-domain Pilin PF00114.17 001009043.1_39724001_2 - 0.38 11.5 2.1 1.3 9.9 0.0 2.7 3 0 0 3 3 3 0 Pilin (bacterial filament) ATP1G1_PLM_MAT8 PF02038.14 001009043.1_39724001_2 - 4.7 6.5 6.0 0.37 10.1 0.9 1.8 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family Arf PF00025.19 022385.3_45722001_1 - 5.9e-77 256.9 0.0 7.2e-77 256.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 022385.3_45722001_1 - 5.4e-14 52.3 0.0 7.9e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 022385.3_45722001_1 - 3e-13 49.6 0.0 3.8e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 022385.3_45722001_1 - 3.6e-10 39.4 0.0 4.6e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 022385.3_45722001_1 - 4e-10 39.3 0.4 2.6e-06 26.7 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 022385.3_45722001_1 - 4e-09 36.0 0.0 5.4e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 022385.3_45722001_1 - 0.00011 22.1 0.0 0.0002 21.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ArgK PF03308.14 022385.3_45722001_1 - 0.0039 16.1 0.3 0.074 11.9 0.0 2.3 2 1 0 2 2 2 1 ArgK protein GTP_EFTU PF00009.25 022385.3_45722001_1 - 0.004 16.6 0.1 0.022 14.2 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.25 022385.3_45722001_1 - 0.041 14.3 0.1 0.59 10.5 0.1 2.0 2 0 0 2 2 2 0 ABC transporter AAA_18 PF13238.4 022385.3_45722001_1 - 0.052 13.9 0.0 0.081 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.16 022385.3_45722001_1 - 0.13 11.6 0.6 0.61 9.5 0.6 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B Bacteriocin_IIi PF11758.6 022385.3_45722001_3 - 0.47 10.2 2.6 23 4.8 0.6 2.4 2 0 0 2 2 2 0 Aureocin-like type II bacteriocin Casein PF00363.16 001285585.1_09023001_1 - 6.6e-28 97.1 13.4 2.7e-21 75.9 5.4 2.6 2 0 0 2 2 2 2 Casein RAM PF15320.4 001285585.1_09023001_1 - 0.048 14.1 0.2 0.42 11.1 0.1 2.2 2 0 0 2 2 2 0 mRNA cap methylation, RNMT-activating mini protein EST1 PF10374.7 001285585.1_09023001_1 - 0.15 12.6 7.6 0.091 13.3 2.7 2.2 1 1 1 2 2 2 0 Telomerase activating protein Est1 DUF1980 PF09323.8 001285585.1_09023001_1 - 0.15 11.8 6.6 0.16 11.7 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) p450 PF00067.20 001173036.1_09924001_3 - 5.8e-133 443.9 0.0 6.7e-133 443.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.23 021606.3_32927001_1 - 9.6e-64 215.1 0.0 1.4e-63 214.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 021606.3_32927001_1 - 5e-46 157.0 0.0 7e-46 156.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 021606.3_32927001_1 - 0.00012 21.4 0.0 0.00022 20.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 021606.3_32927001_1 - 0.017 14.3 0.0 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SDF PF00375.16 001289943.1_45728001_2 - 3e-104 349.0 29.9 3.9e-80 269.6 14.9 2.1 1 1 1 2 2 2 2 Sodium:dicarboxylate symporter family DUF2207 PF09972.7 001289943.1_45728001_2 - 5.1 5.6 6.7 0.31 9.6 0.4 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) S-methyl_trans PF02574.14 001200042.1_49825001_3 - 1.2e-49 169.4 0.0 1.7e-49 168.9 0.0 1.2 1 0 0 1 1 1 1 Homocysteine S-methyltransferase WW PF00397.24 001171147.1_32929001_3 - 2.8e-21 75.0 2.4 2.7e-10 39.9 0.2 2.5 2 0 0 2 2 2 2 WW domain Ribosomal_L7Ae PF01248.24 001284955.1_29523001_3 - 2.4e-24 84.8 0.2 3.6e-24 84.2 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.9 001284955.1_29523001_3 - 0.0031 17.4 0.1 0.0045 16.9 0.1 1.2 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.4 001284955.1_29523001_3 - 0.088 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 PELOTA RNA binding domain Tubulin PF00091.23 080386.3_26224001_2 - 1.9e-67 227.2 0.0 2.5e-67 226.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 080386.3_26224001_2 - 2.6e-51 172.9 0.0 4.1e-51 172.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 080386.3_26224001_2 - 0.0018 17.8 0.0 0.0034 16.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain adh_short_C2 PF13561.4 214019.2_49823001_1 - 1.8e-62 210.8 0.2 2.4e-62 210.4 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 214019.2_49823001_1 - 9.3e-52 175.2 0.6 1.2e-51 174.8 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 214019.2_49823001_1 - 2.6e-09 37.1 0.3 4.2e-09 36.4 0.3 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.4 214019.2_49823001_1 - 0.00048 19.9 0.6 0.00098 18.9 0.6 1.4 1 0 0 1 1 1 1 NAD(P)H-binding YjeF_N PF03853.13 214019.2_49823001_1 - 0.017 14.9 0.6 0.027 14.2 0.6 1.3 1 0 0 1 1 1 0 YjeF-related protein N-terminus Epimerase PF01370.19 214019.2_49823001_1 - 0.022 14.1 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF3159 PF11361.6 214019.2_49823001_1 - 0.15 11.6 0.4 0.24 11.0 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3159) DEAD PF00270.27 001282055.1_32929001_1 - 5.7e-50 169.4 0.1 1.5e-49 168.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001282055.1_32929001_1 - 1.1e-26 93.3 0.0 1.4e-25 89.7 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CdAMP_rec PF06153.9 001282055.1_32929001_1 - 0.12 12.4 0.1 0.25 11.4 0.1 1.5 1 0 0 1 1 1 0 Cyclic-di-AMP receptor Glycolytic PF00274.17 001171114.1_37924001_2 - 4.4e-175 581.3 0.1 5.2e-175 581.1 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Asp PF00026.21 001171086.1_37923001_3 - 2.6e-122 408.0 4.2 3.1e-122 407.8 4.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001171086.1_37923001_3 - 4.1e-16 59.6 3.3 2.4e-09 37.6 0.1 2.6 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001171086.1_37923001_3 - 1e-10 41.1 1.0 1.7e-10 40.4 1.0 1.4 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.4 001171086.1_37923001_3 - 0.00013 22.5 0.1 0.041 14.4 0.0 2.5 2 0 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.4 001171086.1_37923001_3 - 0.084 13.3 0.0 2.5 8.6 0.0 2.7 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease 7tm_1 PF00001.19 001172990.1_09924001_3 - 1.3e-59 201.5 22.1 2e-59 200.9 22.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001172990.1_09924001_3 - 8.9e-12 44.8 22.7 1.1e-11 44.5 22.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001172990.1_09924001_3 - 4.3e-07 29.4 17.0 4.3e-07 29.4 17.0 1.7 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 001172990.1_09924001_3 - 6e-06 25.6 17.8 6e-06 25.6 17.8 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001172990.1_09924001_3 - 0.019 14.6 22.7 0.2 11.2 22.7 2.0 1 1 0 1 1 1 0 Olfactory receptor Neur_chan_LBD PF02931.21 001172707.1_09925001_1 - 1.7e-55 187.6 3.2 2.2e-55 187.3 3.2 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 001172707.1_09925001_1 - 1.8e-37 129.5 0.0 2.6e-37 129.0 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF1127 PF06568.9 001172707.1_09925001_1 - 0.026 14.1 0.3 0.053 13.1 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1127) Kazal_2 PF07648.13 008047.5_32928001_3 - 1.7e-12 47.2 4.9 5.4e-12 45.6 4.9 2.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain FOLN PF09289.8 008047.5_32928001_3 - 1.6e-06 28.0 1.9 5.1e-06 26.4 1.9 2.0 1 0 0 1 1 1 1 Follistatin/Osteonectin-like EGF domain Kazal_1 PF00050.19 008047.5_32928001_3 - 8.4e-06 25.6 9.6 2.6e-05 24.0 9.6 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Pacifastin_I PF05375.11 008047.5_32928001_3 - 2.9e-05 23.6 9.5 0.00013 21.5 9.5 2.2 1 0 0 1 1 1 1 Pacifastin inhibitor (LCMII) EF-hand_6 PF13405.4 008047.5_32928001_3 - 0.0044 16.7 0.2 2.6 8.1 0.3 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.4 008047.5_32928001_3 - 0.0045 17.3 1.3 0.0089 16.3 1.3 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 008047.5_32928001_3 - 0.029 13.8 1.0 3.2 7.4 0.4 2.6 2 0 0 2 2 2 0 EF hand Kazal_1 PF00050.19 001256895.1_39721001_3 - 2e-13 50.0 5.8 2.8e-13 49.5 5.8 1.2 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 001256895.1_39721001_3 - 2.1e-10 40.5 1.7 3.3e-10 39.8 1.7 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain AA_permease_2 PF13520.4 182728.2_26227001_3 - 2.7e-42 145.0 22.3 3.7e-42 144.5 22.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 182728.2_26227001_3 - 5.1e-24 84.6 19.5 7e-24 84.1 19.5 1.1 1 0 0 1 1 1 1 Amino acid permease Asp PF00026.21 001267767.1_08023001_3 - 2.9e-123 411.2 5.7 3.4e-123 411.0 5.7 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001267767.1_08023001_3 - 4.8e-16 59.4 2.9 8.1e-14 52.1 2.9 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001267767.1_08023001_3 - 5.8e-08 32.3 0.9 9.4e-08 31.6 0.9 1.3 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.4 001267767.1_08023001_3 - 0.012 16.2 0.1 0.63 10.6 0.0 2.8 2 1 0 2 2 2 0 Aspartyl protease RhoGEF PF00621.18 027871.2_32928001_1 - 3.2e-37 128.4 0.0 5.1e-37 127.7 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.4 027871.2_32928001_1 - 4.1e-06 26.8 0.5 2.7e-05 24.2 0.5 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 027871.2_32928001_1 - 0.00028 21.2 0.0 0.00062 20.1 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_13 PF16652.3 027871.2_32928001_1 - 0.003 17.3 0.2 0.015 15.0 0.1 2.2 2 1 0 2 2 2 1 Pleckstrin homology domain DUF4347 PF14252.4 057190.2_45726001_1 - 0.00061 19.5 0.0 0.00096 18.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) 7tm_1 PF00001.19 001287630.1_29523001_2 - 2.2e-59 200.8 28.2 3.2e-59 200.3 28.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001287630.1_29523001_2 - 2.1e-09 37.0 26.9 2.7e-09 36.7 26.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001287630.1_29523001_2 - 6.6e-06 25.5 27.6 1.1e-05 24.8 27.6 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001287630.1_29523001_2 - 0.0015 18.1 21.6 0.0034 17.0 21.6 1.5 1 1 0 1 1 1 1 Olfactory receptor MWFE PF15879.3 001287630.1_29523001_2 - 0.11 12.5 0.6 1.1 9.3 0.1 2.6 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit Ni_hydr_CYTB PF01292.18 001287630.1_29523001_2 - 0.34 10.3 3.6 0.17 11.3 0.4 2.0 2 1 0 2 2 2 0 Prokaryotic cytochrome b561 Dynactin_p22 PF07426.9 024348.3_26222001_1 - 8.3e-09 35.4 0.6 1.1e-08 35.0 0.6 1.1 1 0 0 1 1 1 1 Dynactin subunit p22 Dynactin_p22 PF07426.9 024348.3_26222001_3 - 3.7e-42 143.9 0.0 4.8e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 Dynactin subunit p22 Spidroin_MaSp PF11260.6 024348.3_26222001_3 - 0.032 14.4 0.1 0.062 13.5 0.1 1.4 1 0 0 1 1 1 0 Major ampullate spidroin 1 and 2 RRM_1 PF00076.20 001246482.1_39726001_1 - 4.5e-12 45.5 0.0 4.9e-06 26.1 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.22 001246482.1_39726001_1 - 1.4e-07 32.1 0.0 4.1e-07 30.6 0.0 1.9 2 0 0 2 2 2 1 Exonuclease MTHFR PF02219.15 001284649.1_29525001_1 - 1.3e-119 398.6 0.0 1.7e-119 398.3 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase SR-25 PF10500.7 001284649.1_29525001_1 - 0.45 10.0 2.4 0.68 9.4 2.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NAP PF00956.16 023871.4_32926001_3 - 2.4e-38 131.7 13.1 6.1e-33 114.0 4.3 2.6 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Phage_Mu_Gam PF07352.10 023871.4_32926001_3 - 0.02 14.7 2.6 0.034 13.9 2.6 1.3 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein ZapB PF06005.10 023871.4_32926001_3 - 0.088 13.1 2.9 0.17 12.2 2.9 1.4 1 0 0 1 1 1 0 Cell division protein ZapB DEAD PF00270.27 013506.3_32925001_1 - 1.3e-43 148.7 0.3 1.9e-43 148.1 0.3 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 013506.3_32925001_1 - 3.3e-31 107.8 0.7 3.2e-30 104.6 0.1 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 013506.3_32925001_1 - 2.4e-07 30.8 0.0 3.9e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 013506.3_32925001_1 - 0.00017 21.8 0.3 0.0004 20.6 0.1 1.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 013506.3_32925001_1 - 0.0035 16.9 0.0 0.0061 16.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.12 013506.3_32925001_1 - 0.11 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Helicase SNF2_N PF00176.21 013506.3_32925001_1 - 0.13 10.8 0.2 0.96 8.0 0.0 2.0 2 0 0 2 2 2 0 SNF2 family N-terminal domain UvrD-helicase PF00580.19 013506.3_32925001_1 - 0.17 11.2 0.1 0.26 10.6 0.1 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Apolipoprotein PF01442.16 001281657.1_31322001_2 - 2.6e-52 177.4 6.7 4.1e-52 176.8 6.7 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain YtxH PF12732.5 001281657.1_31322001_2 - 4.4e-07 30.2 6.2 0.061 13.7 0.1 4.9 2 1 2 4 4 4 3 YtxH-like protein ApoLp-III PF07464.9 001281657.1_31322001_2 - 1e-05 25.6 1.5 0.089 12.7 0.9 3.4 1 1 0 2 2 2 2 Apolipophorin-III precursor (apoLp-III) DUF883 PF05957.11 001281657.1_31322001_2 - 2.7e-05 24.5 5.7 0.52 10.8 0.3 4.2 2 1 3 5 5 4 2 Bacterial protein of unknown function (DUF883) DUF1640 PF07798.9 001281657.1_31322001_2 - 0.0003 20.8 1.1 0.00093 19.2 0.1 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1640) Exonuc_VII_L PF02601.13 001281657.1_31322001_2 - 0.00053 19.5 3.7 0.0007 19.1 3.7 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit Gp-FAR-1 PF05823.10 001281657.1_31322001_2 - 0.00092 19.4 0.4 0.63 10.2 0.0 2.4 1 1 1 2 2 2 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) OmpH PF03938.12 001281657.1_31322001_2 - 0.0038 17.1 7.8 0.0057 16.5 4.1 2.3 1 1 1 2 2 2 1 Outer membrane protein (OmpH-like) DUF445 PF04286.10 001281657.1_31322001_2 - 0.0051 16.5 0.7 0.018 14.7 0.7 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF445) Baculo_PEP_C PF04513.10 001281657.1_31322001_2 - 0.0056 16.6 0.0 1.8 8.5 0.0 3.1 1 1 1 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1515 PF07439.9 001281657.1_31322001_2 - 0.014 15.2 0.7 0.034 14.0 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) KMP11 PF03037.14 001281657.1_31322001_2 - 0.024 15.3 3.3 3.2 8.5 0.0 3.0 1 1 2 3 3 3 0 Kinetoplastid membrane protein 11 DUF3618 PF12277.6 001281657.1_31322001_2 - 0.037 14.1 7.3 27 5.0 0.1 5.2 5 0 0 5 5 5 0 Protein of unknown function (DUF3618) TipAS PF07739.11 001281657.1_31322001_2 - 0.04 14.3 5.8 0.74 10.2 1.4 2.5 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain TBPIP PF07106.11 001281657.1_31322001_2 - 0.046 13.4 4.4 1.5 8.4 0.1 2.7 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) BshC PF10079.7 001281657.1_31322001_2 - 0.061 11.9 6.1 0.06 12.0 2.5 1.9 1 1 1 2 2 2 0 Bacillithiol biosynthesis BshC WXG100 PF06013.10 001281657.1_31322001_2 - 0.081 13.0 0.5 1.9 8.7 0.1 3.0 1 1 2 3 3 3 0 Proteins of 100 residues with WXG DUF2884 PF11101.6 001281657.1_31322001_2 - 0.093 12.1 4.0 0.15 11.4 1.6 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF2884) ApoO PF09769.7 001281657.1_31322001_2 - 0.14 12.0 0.3 11 5.9 0.2 2.6 1 1 1 2 2 2 0 Apolipoprotein O HIP1_clath_bdg PF16515.3 001281657.1_31322001_2 - 0.25 11.8 9.6 0.11 12.9 2.5 2.6 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Phasin PF05597.9 001281657.1_31322001_2 - 0.26 11.2 3.7 3.3 7.6 0.8 2.9 1 1 3 4 4 4 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF948 PF06103.9 001281657.1_31322001_2 - 0.31 11.2 3.4 2.6 8.2 0.1 3.2 3 1 0 3 3 2 0 Bacterial protein of unknown function (DUF948) HSBP1 PF06825.10 001281657.1_31322001_2 - 1.4 8.7 3.8 29 4.5 0.2 3.2 3 1 0 3 3 3 0 Heat shock factor binding protein 1 FlgN PF05130.10 001281657.1_31322001_2 - 2.5 8.5 8.7 1.2 9.5 3.5 2.4 1 1 1 2 2 2 0 FlgN protein FUSC PF04632.10 001281657.1_31322001_2 - 2.9 6.2 5.0 1.1 7.6 1.1 1.7 1 1 1 2 2 2 0 Fusaric acid resistance protein family Ku_C PF03730.12 001281657.1_31322001_2 - 5 7.8 8.1 28 5.3 2.8 3.3 1 1 1 2 2 2 0 Ku70/Ku80 C-terminal arm IATP PF04568.10 001281657.1_31322001_2 - 9.3 6.6 10.2 2.4 8.5 0.8 3.2 2 2 1 3 3 3 0 Mitochondrial ATPase inhibitor, IATP Guanylin PF02058.13 001160274.1_49822001_2 - 6.7e-36 122.5 1.2 9.1e-36 122.1 1.2 1.2 1 0 0 1 1 1 1 Guanylin precursor Glyco_tran_28_C PF04101.14 001257230.1_26228001_1 - 2.4e-18 66.5 0.0 6e-18 65.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain OTU PF02338.17 001257230.1_26228001_1 - 2.6e-12 47.2 0.0 7.3e-12 45.8 0.0 1.8 1 0 0 1 1 1 1 OTU-like cysteine protease Dynamin_N PF00350.21 001243039.1_32929001_3 - 0.00034 20.6 0.0 0.00034 20.6 0.0 3.3 4 0 0 4 4 4 1 Dynamin family MMR_HSR1 PF01926.21 001243039.1_32929001_3 - 0.0021 18.0 0.1 0.014 15.4 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase HECT PF00632.23 001287059.1_26229001_2 - 3.2e-106 355.2 0.0 4.4e-106 354.7 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HECW_N PF16562.3 001287059.1_26229001_2 - 7.2e-59 196.7 0.5 1.3e-58 195.9 0.5 1.4 1 0 0 1 1 1 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 WW PF00397.24 001287059.1_26229001_2 - 3.7e-16 58.7 0.8 3.8e-08 33.0 0.9 2.5 2 0 0 2 2 2 2 WW domain C2 PF00168.28 001287059.1_26229001_2 - 2.4e-11 43.7 0.0 6.8e-11 42.2 0.0 1.7 1 0 0 1 1 1 1 C2 domain Keratin_B2_2 PF13885.4 001287059.1_26229001_2 - 0.46 10.3 31.4 1.5 8.7 31.4 1.8 1 0 0 1 1 1 0 Keratin, high sulfur B2 protein Pkinase PF00069.23 001277898.1_32925001_2 - 6.1e-72 242.0 0.0 7.4e-72 241.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001277898.1_32925001_2 - 1.8e-33 115.8 0.0 2.5e-33 115.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001277898.1_32925001_2 - 4.6e-08 32.6 0.0 6.3e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RAG2 PF03089.12 001171141.1_37924001_1 - 1.4e-195 648.9 0.1 1.7e-195 648.6 0.1 1.1 1 0 0 1 1 1 1 Recombination activating protein 2 RAG2_PHD PF13341.4 001171141.1_37924001_1 - 1.2e-47 159.7 3.4 2.3e-47 158.8 3.4 1.5 1 0 0 1 1 1 1 RAG2 PHD domain Kelch_5 PF13854.4 001171141.1_37924001_1 - 1.9e-05 24.4 0.9 0.69 9.8 0.0 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.4 001171141.1_37924001_1 - 3e-05 24.1 0.1 0.0064 16.6 0.0 3.9 4 1 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.4 001171141.1_37924001_1 - 0.00035 20.3 0.1 24 4.9 0.0 5.0 5 0 0 5 5 5 1 Galactose oxidase, central domain PHD PF00628.27 001171141.1_37924001_1 - 0.024 14.4 0.6 0.024 14.4 0.6 2.4 2 0 0 2 2 2 0 PHD-finger Apo-CII PF05355.9 001172914.2_09921001_2 - 2.7e-36 123.4 0.8 3.4e-36 123.1 0.8 1.1 1 0 0 1 1 1 1 Apolipoprotein C-II GRASP55_65 PF04495.12 027352.4_32925001_1 - 1.7e-71 238.8 0.0 2.2e-53 180.1 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.4 027352.4_32925001_1 - 2.4e-07 30.8 0.0 0.0018 18.4 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.22 027352.4_32925001_1 - 0.025 14.8 0.0 0.46 10.7 0.0 2.3 2 0 0 2 2 2 0 PDZ domain (Also known as DHR or GLGF) Zip PF02535.20 001166503.1_32926001_2 - 5.5e-29 101.3 3.3 8e-29 100.8 3.3 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter DUF4347 PF14252.4 001270627.1_45726001_1 - 0.00055 19.6 0.0 0.00088 19.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) I-set PF07679.14 001164767.1_32929001_1 - 3.6e-80 264.0 0.0 5.7e-19 67.8 0.0 6.4 6 1 0 6 6 6 5 Immunoglobulin I-set domain Ig_3 PF13927.4 001164767.1_32929001_1 - 4.1e-73 241.9 0.0 2.9e-13 50.1 0.0 6.0 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 001164767.1_32929001_1 - 1.2e-46 156.7 0.0 9.2e-11 41.6 0.0 6.0 5 2 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 001164767.1_32929001_1 - 3.8e-46 155.2 0.0 1.8e-09 37.7 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain fn3 PF00041.19 001164767.1_32929001_1 - 1.8e-30 105.0 2.9 2.1e-12 47.1 0.5 3.6 3 0 0 3 3 3 3 Fibronectin type III domain V-set PF07686.15 001164767.1_32929001_1 - 4.7e-26 90.9 0.6 0.00099 19.1 0.0 8.4 6 2 0 6 6 6 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 001164767.1_32929001_1 - 4.3e-13 49.0 2.2 0.068 13.1 0.0 6.0 6 0 0 6 6 6 5 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.3 001164767.1_32929001_1 - 1.4e-07 31.9 0.0 0.014 15.8 0.1 3.3 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Sp38 PF07354.10 001164767.1_32929001_1 - 0.098 11.4 0.0 11 4.7 0.0 2.6 3 0 0 3 3 3 0 Zona-pellucida-binding protein (Sp38) CBX7_C PF17218.1 001164767.1_32929001_1 - 0.12 12.0 0.0 0.32 10.6 0.0 1.8 1 0 0 1 1 1 0 CBX family C-terminal motif RAMP PF04901.11 001173010.1_09922001_3 - 3.9e-40 136.1 0.4 7.1e-40 135.3 0.4 1.4 1 0 0 1 1 1 1 Receptor activity modifying family RhoGAP PF00620.25 001287530.1_32929001_1 - 2.2e-47 160.6 0.1 3.9e-47 159.7 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain Peptidase_M6 PF05547.9 001287530.1_32929001_1 - 0.23 9.5 0.0 0.32 9.0 0.0 1.1 1 0 0 1 1 1 0 Immune inhibitor A peptidase M6 p450 PF00067.20 001195764.1_37923001_1 - 7.3e-153 509.5 0.0 8.3e-153 509.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.4 001172960.2_09923001_2 - 3.9e-14 52.8 0.0 5.9e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001172960.2_09923001_2 - 7.3e-08 32.9 0.0 1.7e-07 31.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.4 001172960.2_09923001_2 - 0.00078 19.1 0.0 0.0018 17.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.7 001172960.2_09923001_2 - 0.022 14.4 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase RAMP PF04901.11 001173009.1_09922001_1 - 3.9e-44 149.0 0.0 5.4e-44 148.6 0.0 1.2 1 0 0 1 1 1 1 Receptor activity modifying family Aldedh PF00171.20 001283301.1_29525001_3 - 2.1e-184 613.2 0.0 2.4e-184 613.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.12 001283301.1_29525001_3 - 0.0013 17.7 0.0 0.0022 17.0 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) DEAD PF00270.27 001257173.1_26224001_3 - 4.2e-29 101.4 0.0 6.8e-29 100.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001257173.1_26224001_3 - 1.4e-26 92.9 0.0 3.3e-26 91.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 001257173.1_26224001_3 - 0.0001 22.2 0.0 0.00018 21.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit BAR PF03114.16 019464.3_32929001_1 - 1.6e-73 247.2 4.5 2.4e-73 246.6 4.5 1.2 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.4 019464.3_32929001_1 - 1.1e-10 41.0 0.1 7.3e-10 38.4 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain BAR_2 PF10455.7 019464.3_32929001_1 - 2e-09 36.9 0.4 3e-09 36.3 0.4 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.3 019464.3_32929001_1 - 9.2e-08 31.9 0.5 1.4e-07 31.3 0.5 1.2 1 0 0 1 1 1 1 BAR domain of APPL family SH3_1 PF00018.26 019464.3_32929001_1 - 3.9e-07 29.4 0.0 7.1e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 019464.3_32929001_1 - 1.1e-05 24.9 0.0 2.2e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Aph-1 PF06105.10 001145646.1_26229001_3 - 1.2e-55 188.3 19.1 1.4e-37 129.2 4.3 2.3 1 1 1 2 2 2 2 Aph-1 protein Mg_trans_NIPA PF05653.12 001256133.1_32926001_2 - 1.1e-128 428.3 13.7 1.6e-128 427.8 13.7 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.18 001256133.1_32926001_2 - 5.6e-09 36.1 4.1 5.6e-09 36.1 4.1 3.4 3 0 0 3 3 3 1 EamA-like transporter family Ferritin PF00210.22 001009786.2_39522001_2 - 4.6e-38 130.2 4.0 6e-38 129.8 4.0 1.2 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.15 001009786.2_39522001_2 - 0.015 15.6 0.3 0.02 15.1 0.3 1.3 1 0 0 1 1 1 0 Rubrerythrin Ndr PF03096.12 001195006.1_32926001_1 - 7.3e-123 408.6 0.0 8.9e-123 408.3 0.0 1.1 1 0 0 1 1 1 1 Ndr family Abhydrolase_1 PF00561.18 001195006.1_32926001_1 - 0.1 12.1 0.1 0.22 11.0 0.1 1.5 1 1 1 2 2 2 0 alpha/beta hydrolase fold 7tm_2 PF00002.22 001974.4_26227001_1 - 1.8e-64 217.2 26.6 2.6e-64 216.7 26.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) EGF_CA PF07645.13 001974.4_26227001_1 - 2.9e-48 161.7 76.7 9.5e-10 38.4 5.1 7.5 6 1 1 7 7 7 6 Calcium-binding EGF domain cEGF PF12662.5 001974.4_26227001_1 - 4.3e-32 109.5 57.8 1.5e-09 37.5 1.4 7.8 8 0 0 8 8 8 6 Complement Clr-like EGF-like EGF_3 PF12947.5 001974.4_26227001_1 - 7.4e-20 70.7 70.7 0.00019 21.4 2.8 7.7 7 1 0 7 7 7 6 EGF domain EGF_MSP1_1 PF12946.5 001974.4_26227001_1 - 9.9e-18 63.8 63.4 2.8e-06 27.1 3.0 7.2 7 0 0 7 7 7 6 MSP1 EGF domain 1 Plasmod_Pvs28 PF06247.9 001974.4_26227001_1 - 3.4e-10 39.9 67.8 0.0064 16.6 2.1 8.0 8 0 0 8 8 8 5 Pvs28 EGF domain GPS PF01825.19 001974.4_26227001_1 - 2.8e-08 34.1 1.5 2.8e-08 34.1 1.5 4.5 5 0 0 5 5 2 1 GPCR proteolysis site, GPS, motif hEGF PF12661.5 001974.4_26227001_1 - 2.8e-07 30.8 82.4 0.012 16.1 7.3 8.0 8 0 0 8 8 7 5 Human growth factor-like EGF FXa_inhibition PF14670.4 001974.4_26227001_1 - 0.0001 22.4 81.6 0.088 13.0 5.7 7.7 6 1 1 7 7 7 4 Coagulation Factor Xa inhibitory site EGF PF00008.25 001974.4_26227001_1 - 0.0004 20.5 79.5 0.026 14.7 7.4 7.2 6 0 0 6 6 6 5 EGF-like domain GAIN PF16489.3 001974.4_26227001_1 - 0.15 11.3 0.6 0.24 10.7 0.6 1.2 1 0 0 1 1 1 0 GPCR-Autoproteolysis INducing (GAIN) domain EB PF01683.16 001974.4_26227001_1 - 3.6 7.8 84.3 0.11 12.7 6.3 7.6 7 0 0 7 7 6 0 EB module RasGEF PF00617.17 001177811.1_32928001_3 - 1e-39 136.3 0.1 1.7e-39 135.6 0.1 1.4 1 0 0 1 1 1 1 RasGEF domain cNMP_binding PF00027.27 001177811.1_32928001_3 - 1.5e-16 60.1 0.0 3.6e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DEP PF00610.19 001177811.1_32928001_3 - 1.6e-16 60.0 0.1 3.5e-16 58.9 0.1 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RasGEF_N PF00618.18 001177811.1_32928001_3 - 1.7e-14 53.8 0.0 3.8e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif Aminotran_4 PF01063.17 001243052.1_32924001_2 - 2.1e-30 106.1 0.0 2.9e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV DEAD PF00270.27 001284712.1_29525001_2 - 7.9e-44 149.4 0.2 1.6e-43 148.4 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001284712.1_29525001_2 - 1.6e-31 108.8 0.6 2.5e-30 104.9 0.1 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 001284712.1_29525001_2 - 1.1e-06 28.7 0.0 1.1e-06 28.7 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 001284712.1_29525001_2 - 0.00014 22.1 0.3 0.00039 20.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 001284712.1_29525001_2 - 0.0012 18.5 0.0 0.002 17.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain CMS1 PF14617.4 001284712.1_29525001_2 - 1.4 8.0 0.0 1.4 8.0 0.0 2.9 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit NTP_transferase PF00483.21 001285349.1_29524001_3 - 2.5e-16 59.9 0.0 5.2e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.5 001285349.1_29524001_3 - 1.8e-15 57.5 0.0 2.8e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.3 001285349.1_29524001_3 - 3.4e-05 22.1 1.1 5e-05 21.5 1.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Hexapep PF00132.22 001285349.1_29524001_3 - 5.1e-05 22.7 3.8 0.14 11.8 2.2 3.7 1 1 2 3 3 3 2 Bacterial transferase hexapeptide (six repeats) CTP_transf_3 PF02348.17 001285349.1_29524001_3 - 0.015 15.1 0.1 0.088 12.6 0.0 1.9 2 0 0 2 2 2 0 Cytidylyltransferase Fucokinase PF07959.10 001285349.1_29524001_3 - 0.17 10.7 5.2 0.3 9.9 4.0 1.9 2 1 0 2 2 2 0 L-fucokinase Arm PF00514.21 001163533.1_32923001_2 - 6.5e-19 67.2 12.9 2.7e-06 27.1 0.0 7.3 7 1 2 9 9 9 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 001163533.1_32923001_2 - 1.2e-13 51.1 9.4 6.2e-06 26.4 1.5 4.5 1 1 4 5 5 5 5 HEAT repeats HEAT PF02985.20 001163533.1_32923001_2 - 1.2e-10 40.5 8.7 0.0082 16.2 0.0 6.8 8 0 0 8 8 8 3 HEAT repeat Cnd1 PF12717.5 001163533.1_32923001_2 - 1.3e-08 34.9 6.8 0.00063 19.6 1.5 3.4 1 1 2 3 3 3 3 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.18 001163533.1_32923001_2 - 5.6e-08 31.7 8.9 1.6e-07 30.2 5.5 2.3 1 1 1 2 2 2 1 Adaptin N terminal region HEAT_EZ PF13513.4 001163533.1_32923001_2 - 7.8e-07 29.3 9.4 0.045 14.1 0.0 6.0 5 2 1 6 6 6 2 HEAT-like repeat Vac14_Fab1_bd PF12755.5 001163533.1_32923001_2 - 2.7e-06 27.7 0.3 0.064 13.7 0.0 2.8 2 2 1 3 3 3 3 Vacuolar 14 Fab1-binding region UNC45-central PF11701.6 001163533.1_32923001_2 - 0.00074 19.4 2.8 0.02 14.7 0.2 3.0 3 0 0 3 3 3 1 Myosin-binding striated muscle assembly central V-ATPase_H_N PF03224.12 001163533.1_32923001_2 - 0.0052 16.0 4.2 0.033 13.4 2.4 2.6 1 1 1 2 2 2 1 V-ATPase subunit H DUF3636 PF12331.6 001163533.1_32923001_2 - 0.0071 16.1 1.9 0.054 13.2 0.3 2.8 2 1 0 3 3 3 1 Protein of unknown function (DUF3636) RTP1_C1 PF10363.7 001163533.1_32923001_2 - 0.0079 16.2 3.6 0.58 10.2 1.3 3.6 1 1 1 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 Proteasom_PSMB PF10508.7 001163533.1_32923001_2 - 0.26 9.6 9.2 0.16 10.3 1.3 3.1 1 1 2 3 3 3 0 Proteasome non-ATPase 26S subunit RasGEF_N_2 PF14663.4 001163533.1_32923001_2 - 1.5 9.1 9.4 6.6 7.0 0.1 4.4 3 3 1 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Arrestin_N PF00339.27 001285259.1_29524001_2 - 4.3e-46 156.5 0.0 3.1e-41 140.7 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 001285259.1_29524001_2 - 1.4e-27 96.6 0.2 2.9e-27 95.6 0.1 1.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain BatD PF13584.4 001285259.1_29524001_2 - 0.063 12.0 0.1 0.089 11.5 0.1 1.1 1 0 0 1 1 1 0 Oxygen tolerance AP3B1_C PF14796.4 001285259.1_29524001_2 - 0.093 12.8 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal NO_synthase PF02898.13 001172984.1_09928001_3 - 1.4e-186 619.7 0.0 1.8e-186 619.4 0.0 1.1 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.18 001172984.1_09928001_3 - 1.2e-76 257.0 0.0 1.9e-76 256.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 001172984.1_09928001_3 - 4.9e-40 136.9 0.0 1e-39 135.9 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.19 001172984.1_09928001_3 - 8.3e-21 74.6 0.0 1.6e-20 73.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.10 001172984.1_09928001_3 - 0.0069 16.4 0.0 0.028 14.4 0.0 2.0 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Annexin PF00191.18 001163998.1_49824001_3 - 5.2e-88 289.0 14.9 3.3e-25 87.8 0.6 4.2 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.3 001163998.1_49824001_3 - 9.5e-05 22.1 1.1 3.4 7.5 0.0 3.5 2 1 1 3 3 3 3 Myb DNA-binding like Pkinase PF00069.23 001270544.1_45728001_3 - 6.3e-63 212.5 0.0 8e-63 212.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001270544.1_45728001_3 - 3.8e-28 98.3 0.1 5.5e-28 97.8 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001270544.1_45728001_3 - 9.3e-06 25.0 0.4 1.5e-05 24.4 0.4 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001270544.1_45728001_3 - 0.002 18.0 0.0 0.0035 17.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.20 001270544.1_45728001_3 - 0.0024 17.4 0.3 0.0039 16.7 0.3 1.2 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.4 001270544.1_45728001_3 - 0.003 16.8 0.0 0.0049 16.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Annexin PF00191.18 001171152.1_37923001_1 - 7e-90 295.0 14.7 1.1e-25 89.3 0.5 4.1 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.3 001171152.1_37923001_1 - 0.012 15.3 4.9 13 5.6 0.0 4.6 4 1 1 5 5 5 0 Myb DNA-binding like WW PF00397.24 009534.3_32929001_3 - 2.7e-21 75.1 2.4 2.7e-10 39.9 0.2 2.5 2 0 0 2 2 2 2 WW domain Pkinase PF00069.23 001276715.1_45726001_1 - 5.6e-71 238.9 0.0 8.5e-71 238.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001276715.1_45726001_1 - 3.1e-33 115.0 0.0 5.1e-33 114.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 001276715.1_45726001_1 - 3.6e-28 97.1 20.4 5.9e-14 51.6 4.1 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.27 001276715.1_45726001_1 - 2.7e-09 37.3 0.0 1.4e-08 35.1 0.0 2.1 2 0 0 2 2 2 1 PH domain Kinase-like PF14531.4 001276715.1_45726001_1 - 6.5e-08 32.1 0.0 2e-07 30.5 0.0 1.7 1 1 0 1 1 1 1 Kinase-like C1_2 PF03107.14 001276715.1_45726001_1 - 7.3e-06 26.1 14.8 0.0048 17.1 5.9 2.5 2 0 0 2 2 2 2 C1 domain Kdo PF06293.12 001276715.1_45726001_1 - 6e-05 22.4 0.0 0.00013 21.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_9 PF13901.4 001276715.1_45726001_1 - 0.034 14.0 12.3 0.52 10.1 0.4 2.4 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon APH PF01636.21 001276715.1_45726001_1 - 0.19 11.5 1.6 0.99 9.1 0.0 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family FYVE_2 PF02318.14 001276715.1_45726001_1 - 1.8 8.7 10.4 6 7.0 5.1 2.4 2 0 0 2 2 2 0 FYVE-type zinc finger PHD PF00628.27 001276715.1_45726001_1 - 2.4 8.0 21.1 5.8 6.8 4.8 2.5 2 0 0 2 2 2 0 PHD-finger PHD_2 PF13831.4 001276715.1_45726001_1 - 7.6 6.0 9.5 14 5.1 0.5 2.7 2 0 0 2 2 2 0 PHD-finger S_100 PF01023.17 001195742.1_37921001_2 - 1.2e-17 63.1 0.5 2.1e-17 62.4 0.5 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 001195742.1_37921001_2 - 7.1e-07 29.5 0.6 1e-06 29.0 0.6 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001195742.1_37921001_2 - 0.00025 20.3 1.2 0.0023 17.2 0.3 2.3 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 001195742.1_37921001_2 - 0.023 14.5 0.6 3.8 7.6 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain Pyridoxal_deC PF00282.17 001172943.1_09924001_1 - 1.6e-171 570.0 0.0 1.9e-171 569.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.19 001172943.1_09924001_1 - 4.2e-05 22.8 0.0 7.6e-05 22.0 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.19 001172943.1_09924001_1 - 0.068 12.2 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II Myb_DNA-binding PF00249.29 009584.4_32925001_3 - 1e-22 79.8 3.8 6.9e-12 45.2 0.2 3.2 3 0 0 3 3 3 2 Myb-like DNA-binding domain RAC_head PF16717.3 009584.4_32925001_3 - 7.6e-21 74.7 10.7 7.6e-21 74.7 10.7 4.6 5 2 0 5 5 5 1 Ribosome-associated complex head domain DnaJ PF00226.29 009584.4_32925001_3 - 6.6e-15 54.9 0.1 6.6e-15 54.9 0.1 2.6 2 0 0 2 2 2 1 DnaJ domain Myb_DNA-bind_6 PF13921.4 009584.4_32925001_3 - 1.9e-11 43.9 1.7 1.2e-06 28.5 0.2 3.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Cu-oxidase_3 PF07732.13 001282141.1_26228001_3 - 2.8e-21 75.6 0.1 2.8e-07 30.4 0.0 4.5 4 0 0 4 4 4 3 Multicopper oxidase Cu-oxidase_2 PF07731.12 001282141.1_26228001_3 - 2.4e-19 69.3 17.0 7.1e-15 54.8 1.7 5.9 6 1 0 6 6 6 2 Multicopper oxidase Ndr PF03096.12 001195153.2_39724001_1 - 8.9e-123 408.4 0.0 1.1e-122 408.1 0.0 1.1 1 0 0 1 1 1 1 Ndr family Abhydrolase_1 PF00561.18 001195153.2_39724001_1 - 0.0029 17.1 0.0 0.0056 16.2 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 001195153.2_39724001_1 - 0.089 11.9 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 B12D PF06522.9 001195153.2_39724001_1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit LCAT PF02450.13 001164856.1_49823001_3 - 1.9e-124 415.6 0.1 2.3e-87 293.6 0.0 2.8 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.5 001164856.1_49823001_3 - 0.0001 22.9 0.5 0.00019 22.0 0.5 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 001164856.1_49823001_3 - 0.0038 16.4 0.0 0.007 15.5 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 MarR_2 PF12802.5 001164856.1_49823001_3 - 0.017 14.9 0.0 1.2 9.0 0.0 2.8 2 1 1 3 3 3 0 MarR family HTH_IclR PF09339.8 001164856.1_49823001_3 - 0.023 14.4 0.1 4.4 7.0 0.0 2.5 2 0 0 2 2 2 0 IclR helix-turn-helix domain UBA PF00627.29 001164856.1_49823001_3 - 0.024 14.4 0.0 9.7 6.1 0.0 2.3 2 0 0 2 2 2 0 UBA/TS-N domain Ser_hydrolase PF06821.11 001164856.1_49823001_3 - 0.048 13.4 0.0 0.092 12.5 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase DUF1749 PF08538.8 001164856.1_49823001_3 - 0.18 10.7 0.0 0.3 10.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Casein PF00363.16 001172894.1_09923001_2 - 5.8e-19 68.4 1.2 5.8e-19 68.4 1.2 2.5 3 0 0 3 3 3 2 Casein YtzH PF14165.4 001172894.1_09923001_2 - 0.016 15.4 1.4 0.026 14.8 0.3 1.9 2 0 0 2 2 2 0 YtzH-like protein EspB PF05802.9 001172894.1_09923001_2 - 0.027 13.5 0.8 0.049 12.6 0.8 1.3 1 0 0 1 1 1 0 Enterobacterial EspB protein HCO3_cotransp PF00955.19 001173017.1_09929001_1 - 3.5e-210 699.1 2.0 4.7e-210 698.7 2.0 1.2 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 001173017.1_09929001_1 - 6.2e-106 354.0 0.2 9.5e-106 353.4 0.2 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.20 001173017.1_09929001_1 - 0.00017 21.3 0.0 0.00032 20.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 UPF0561 PF10573.7 001173017.1_09929001_1 - 0.31 11.1 2.6 0.84 9.6 2.6 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 RhoGEF PF00621.18 001047159.2_32928001_2 - 1.1e-34 120.2 0.0 2e-34 119.3 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.3 001047159.2_32928001_2 - 3.9e-07 30.0 0.0 2.8e-06 27.2 0.0 2.2 2 1 0 2 2 2 1 Pleckstrin homology domain PH_5 PF15405.4 001047159.2_32928001_2 - 1.2e-06 28.6 0.1 2.7e-06 27.4 0.1 1.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 001047159.2_32928001_2 - 1.9e-06 28.2 0.0 3.5e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.3 001047159.2_32928001_2 - 0.092 12.6 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 PH domain zf-RING_2 PF13639.4 001277278.1_45729001_1 - 4.9e-10 39.4 15.1 1.7e-09 37.6 15.1 2.1 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.23 001277278.1_45729001_1 - 1.1e-05 25.0 10.9 3.8e-05 23.3 10.9 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001277278.1_45729001_1 - 2.7e-05 24.2 11.9 8.5e-05 22.6 11.9 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 001277278.1_45729001_1 - 0.00012 21.7 14.6 0.00045 19.9 14.6 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001277278.1_45729001_1 - 0.00068 19.4 12.3 0.0022 17.8 12.3 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 001277278.1_45729001_1 - 0.00095 19.0 10.0 0.00095 19.0 10.0 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 001277278.1_45729001_1 - 0.0018 17.9 11.8 0.0062 16.2 11.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 001277278.1_45729001_1 - 0.0078 16.1 8.3 0.018 14.9 8.3 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Rad50_zn_hook PF04423.12 001277278.1_45729001_1 - 6.3 6.6 7.5 1.6 8.5 0.1 2.6 2 0 0 2 2 2 0 Rad50 zinc hook motif Filament PF00038.19 001281612.1_31323001_3 - 1.1e-115 386.4 47.6 1.4e-115 386.1 47.6 1.1 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.12 001281612.1_31323001_3 - 8.4e-23 80.9 9.2 1.8e-22 79.9 9.2 1.6 1 0 0 1 1 1 1 Intermediate filament head (DNA binding) region Reo_sigmaC PF04582.10 001281612.1_31323001_3 - 0.00035 19.9 5.6 0.43 9.8 0.3 3.2 1 1 2 3 3 3 2 Reovirus sigma C capsid protein Spc7 PF08317.9 001281612.1_31323001_3 - 0.0011 17.8 8.7 0.0011 17.8 8.7 3.1 1 1 2 3 3 3 1 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.7 001281612.1_31323001_3 - 0.0016 18.6 39.0 0.25 11.4 14.7 3.9 1 1 2 3 3 3 2 JNK_SAPK-associated protein-1 Trimer_CC PF08954.9 001281612.1_31323001_3 - 0.032 13.6 0.2 0.032 13.6 0.2 4.2 4 0 0 4 4 4 0 Trimerisation motif DUF1664 PF07889.10 001281612.1_31323001_3 - 0.033 14.1 20.9 0.062 13.2 2.4 4.4 1 1 3 5 5 5 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.10 001281612.1_31323001_3 - 0.065 13.1 15.8 0.44 10.5 0.8 4.2 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus HALZ PF02183.16 001281612.1_31323001_3 - 0.076 13.1 23.1 0.55 10.3 2.2 5.8 7 1 0 7 7 5 0 Homeobox associated leucine zipper CENP-H PF05837.10 001281612.1_31323001_3 - 0.12 12.7 33.1 0.12 12.7 3.5 4.3 1 1 4 5 5 5 0 Centromere protein H (CENP-H) Golgin_A5 PF09787.7 001281612.1_31323001_3 - 0.14 11.4 37.9 0.15 11.3 9.1 2.8 1 1 0 2 2 2 0 Golgin subfamily A member 5 DUF5082 PF16888.3 001281612.1_31323001_3 - 0.19 11.9 26.2 0.76 10.0 0.2 5.0 1 1 4 5 5 5 0 Domain of unknown function (DUF5082) bZIP_1 PF00170.19 001281612.1_31323001_3 - 0.25 11.3 21.3 2.5 8.1 1.3 5.9 4 1 2 6 6 6 0 bZIP transcription factor DUF573 PF04504.12 001281612.1_31323001_3 - 0.33 11.5 8.6 4 8.0 0.4 4.0 2 2 1 3 3 3 0 Protein of unknown function, DUF573 IncA PF04156.12 001281612.1_31323001_3 - 0.33 10.6 43.6 2.8 7.6 13.4 3.9 1 1 2 3 3 3 0 IncA protein HMMR_N PF15905.3 001281612.1_31323001_3 - 0.36 10.1 36.6 0.15 11.3 6.1 3.2 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal TolA_bind_tri PF16331.3 001281612.1_31323001_3 - 0.41 10.6 42.4 0.2 11.6 3.7 6.4 3 1 3 6 6 6 0 TolA binding protein trimerisation GAS PF13851.4 001281612.1_31323001_3 - 0.43 9.8 41.0 0.014 14.7 11.5 4.0 1 1 2 3 3 2 0 Growth-arrest specific micro-tubule binding DUF4407 PF14362.4 001281612.1_31323001_3 - 0.43 9.8 32.9 0.75 9.0 14.6 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.10 001281612.1_31323001_3 - 0.48 10.4 42.2 1.1 9.2 10.3 3.9 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Mnd1 PF03962.13 001281612.1_31323001_3 - 0.66 9.7 33.8 12 5.5 5.3 3.6 1 1 2 3 3 3 0 Mnd1 family APG6 PF04111.10 001281612.1_31323001_3 - 0.88 8.8 40.9 0.083 12.1 2.8 3.3 1 1 2 3 3 2 0 Autophagy protein Apg6 KASH_CCD PF14662.4 001281612.1_31323001_3 - 0.93 9.2 40.2 0.59 9.8 0.4 4.0 1 1 2 4 4 4 0 Coiled-coil region of CCDC155 or KASH WD40_alt PF14077.4 001281612.1_31323001_3 - 1.1 9.0 10.5 36 4.2 1.5 4.7 5 0 0 5 5 4 0 Alternative WD40 repeat motif Patched PF02460.16 001281612.1_31323001_3 - 1.4 6.8 4.7 1.8 6.4 4.7 1.1 1 0 0 1 1 1 0 Patched family SHE3 PF17078.3 001281612.1_31323001_3 - 2.1 7.9 35.0 3.8 7.0 17.9 3.2 1 1 2 3 3 3 0 SWI5-dependent HO expression protein 3 Lectin_N PF03954.12 001281612.1_31323001_3 - 2.3 7.9 9.9 1.1e+02 2.4 4.8 3.8 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DUF3584 PF12128.6 001281612.1_31323001_3 - 2.3 5.5 39.7 3.1 5.1 37.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Prefoldin PF02996.15 001281612.1_31323001_3 - 2.9 7.7 28.7 0.029 14.1 2.2 5.5 4 2 1 5 5 5 0 Prefoldin subunit CENP-F_leu_zip PF10473.7 001281612.1_31323001_3 - 3.2 7.6 35.5 0.66 9.9 4.7 3.1 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HR1 PF02185.14 001281612.1_31323001_3 - 3.4 7.7 34.6 0.64 10.0 1.1 5.1 3 2 2 5 5 5 0 Hr1 repeat Atg14 PF10186.7 001281612.1_31323001_3 - 4.5 6.1 25.3 19 4.1 14.3 2.2 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fib_alpha PF08702.8 001281612.1_31323001_3 - 5 7.2 28.9 0.35 10.9 7.4 3.8 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family KLRAQ PF10205.7 001281612.1_31323001_3 - 6.5 6.9 28.9 1.4 9.1 10.4 4.2 2 2 3 5 5 5 0 Predicted coiled-coil domain-containing protein TACC PF05010.12 001281612.1_31323001_3 - 7.1 6.2 38.8 1.7 8.3 9.8 2.6 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC) AP-5_subunit_s1 PF15001.4 018347.2_26224001_3 - 3.5e-70 235.8 0.0 4.9e-70 235.3 0.0 1.2 1 0 0 1 1 1 1 AP-5 complex subunit sigma-1 Kringle PF00051.16 017017.2_45726001_2 - 8.1e-112 365.6 46.7 7.7e-29 99.7 8.7 4.4 4 0 0 4 4 4 4 Kringle domain Trypsin PF00089.24 017017.2_45726001_2 - 2.3e-51 174.6 0.0 4e-51 173.8 0.0 1.4 1 0 0 1 1 1 1 Trypsin PAN_1 PF00024.24 017017.2_45726001_2 - 3.9e-12 45.8 1.0 1.4e-11 44.1 1.0 2.0 1 0 0 1 1 1 1 PAN domain DUF1986 PF09342.9 017017.2_45726001_2 - 0.0023 18.2 0.0 0.0046 17.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Ependymin PF00811.16 017017.2_45726001_2 - 0.0027 17.8 0.9 3 8.0 0.2 3.5 3 0 0 3 3 3 1 Ependymin DUF316 PF03761.13 017017.2_45726001_2 - 0.014 14.8 0.0 0.054 12.9 0.0 1.8 2 0 0 2 2 2 0 Chymotrypsin family Peptidase-S1 TBP PF00352.19 001281633.1_31323001_1 - 5.6e-66 218.4 0.3 4.6e-32 109.7 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.6 001281633.1_31323001_1 - 0.0011 18.8 3.3 1.3 9.0 0.0 3.3 4 0 0 4 4 4 2 Domain of unknown function (DUF3378) DUF3365 PF11845.6 001281633.1_31323001_1 - 0.023 14.9 1.2 0.034 14.3 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3365) Spt20 PF12090.6 001281633.1_31323001_1 - 0.036 13.6 18.0 0.052 13.0 18.0 1.1 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.11 001281633.1_31323001_1 - 0.062 13.2 12.9 0.073 12.9 12.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EBP50_C PF09007.9 001281633.1_31323001_1 - 0.2 12.5 5.9 0.33 11.8 5.9 1.3 1 0 0 1 1 1 0 EBP50, C-terminal Presenilin PF01080.15 001281633.1_31323001_1 - 0.25 9.9 2.7 0.18 10.3 0.8 1.8 3 0 0 3 3 3 0 Presenilin Tombus_movement PF05318.10 001281633.1_31323001_1 - 0.41 11.4 7.2 0.15 12.8 4.5 1.6 2 0 0 2 2 2 0 Tombusvirus movement protein ANAPC_CDC26 PF10471.7 001281633.1_31323001_1 - 1.7 9.5 19.3 3.5 8.4 19.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Roughex PF06020.9 001281633.1_31323001_1 - 4.6 6.1 13.2 6.8 5.5 13.2 1.1 1 0 0 1 1 1 0 Drosophila roughex protein SLC3A2_N PF16028.3 019283.3_45724001_3 - 7.8e-32 108.5 1.1 1.4e-31 107.7 1.1 1.4 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus Alpha-amylase PF00128.22 019283.3_45724001_3 - 3.1e-18 66.3 0.2 3.7e-12 46.3 0.1 3.1 1 1 2 3 3 3 3 Alpha amylase, catalytic domain Malt_amylase_C PF16657.3 019283.3_45724001_3 - 0.12 12.3 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Maltogenic Amylase, C-terminal domain DUF448 PF04296.11 019283.3_45724001_3 - 0.19 11.5 0.0 0.38 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF448) EMP24_GP25L PF01105.22 001204309.1_39728001_3 - 6.1e-49 166.3 0.3 8.2e-49 165.9 0.3 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD APG5 PF04106.10 053069.6_32925001_2 - 1.4e-60 204.3 0.1 1.9e-60 203.8 0.1 1.2 1 0 0 1 1 1 1 Autophagy protein Apg5 Laminin_N PF00055.15 001312688.1_26229001_1 - 2.1e-54 184.5 1.7 4.8e-54 183.3 0.0 2.2 2 0 0 2 2 2 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.22 001312688.1_26229001_1 - 7.4e-11 41.9 50.0 2.8e-06 27.2 12.1 4.1 3 1 1 4 4 4 2 Laminin EGF domain Globin PF00042.20 001085432.1_21021001_1 - 3.8e-29 101.3 0.1 5.3e-29 100.9 0.1 1.2 1 0 0 1 1 1 1 Globin PI3K_P85_iSH2 PF16454.3 001355585.1_32929001_1 - 7.5e-60 201.0 19.0 1e-59 200.5 19.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SH2 PF00017.22 001355585.1_32929001_1 - 2.2e-40 136.4 0.0 1.3e-19 69.9 0.0 2.5 2 0 0 2 2 2 2 SH2 domain Transcrip_act PF04949.11 001355585.1_32929001_1 - 0.13 12.0 7.2 1.7 8.4 2.1 2.4 1 1 1 2 2 2 0 Transcriptional activator IncA PF04156.12 001355585.1_32929001_1 - 0.3 10.7 11.6 0.52 9.9 11.6 1.3 1 0 0 1 1 1 0 IncA protein Mod_r PF07200.11 001355585.1_32929001_1 - 6.9 6.6 17.8 1.9 8.4 7.3 2.2 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Exonuc_VII_L PF02601.13 001355585.1_32929001_1 - 8.2 5.8 7.9 13 5.2 7.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit TPK_catalytic PF04263.14 001350884.1_26225001_1 - 3.6e-28 97.9 0.0 6.2e-28 97.1 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.12 001350884.1_26225001_1 - 4.9e-24 83.7 0.1 9.9e-24 82.7 0.1 1.6 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain TPK_catalytic PF04263.14 001350884.1_26225001_3 - 0.13 12.2 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, catalytic domain zf-C2H2_4 PF13894.4 001348231.1_32927001_3 - 0.035 14.8 0.2 0.035 14.8 0.2 7.1 6 1 0 6 6 6 0 C2H2-type zinc finger MFS_1_like PF12832.5 001357464.1_32929001_1 - 3.1e-91 306.0 11.2 4.1e-91 305.6 11.2 1.2 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.14 001357464.1_32929001_1 - 5.8e-29 101.0 24.8 9.5e-16 57.5 12.8 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily Nuc_H_symport PF03825.14 001357464.1_32929001_1 - 8.7e-08 31.4 6.8 8.7e-08 31.4 6.8 3.9 3 1 2 5 5 5 2 Nucleoside H+ symporter LacY_symp PF01306.17 001357464.1_32929001_1 - 1e-05 24.4 18.2 0.0036 16.0 3.7 3.2 3 0 0 3 3 3 3 LacY proton/sugar symporter MFS_3 PF05977.11 001357464.1_32929001_1 - 0.0015 16.9 0.9 0.0028 16.0 0.9 1.4 1 0 0 1 1 1 1 Transmembrane secretion effector Aminotran_3 PF00202.19 001310735.1_32925001_2 - 8.7e-93 311.0 0.0 1.5e-92 310.3 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-III Redoxin PF08534.8 001358511.1_26222001_3 - 3.8e-15 55.7 0.0 5.4e-15 55.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.19 001358511.1_26222001_3 - 0.0004 20.2 0.0 0.00053 19.8 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family MutS_V PF00488.19 001311120.1_32928001_2 - 3.8e-71 238.9 0.1 1.2e-70 237.3 0.0 1.9 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.16 001311120.1_32928001_2 - 3.2e-37 128.5 1.4 1.5e-36 126.3 0.3 2.5 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.15 001311120.1_32928001_2 - 1.5e-33 115.9 0.1 5.1e-33 114.1 0.1 2.0 1 0 0 1 1 1 1 MutS domain II MutS_I PF01624.18 001311120.1_32928001_2 - 2e-32 111.6 0.1 4.1e-32 110.7 0.1 1.5 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.16 001311120.1_32928001_2 - 0.00022 21.4 0.0 0.00069 19.8 0.0 1.9 1 0 0 1 1 1 1 MutS family domain IV NPV_P10 PF05531.10 001311120.1_32928001_2 - 0.069 13.5 0.4 1 9.7 0.1 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Cu2_monoox_C PF03712.13 001357127.1_32929001_3 - 9.3e-44 148.6 0.4 1.6e-43 147.8 0.4 1.4 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain NHL PF01436.19 001357127.1_32929001_3 - 4.2e-25 86.4 9.7 1.6e-05 24.6 0.1 5.5 5 0 0 5 5 5 4 NHL repeat Cu2_monooxygen PF01082.18 001357127.1_32929001_3 - 2e-23 82.9 0.0 4.1e-23 82.0 0.0 1.5 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain DUF5128 PF17170.2 001357127.1_32929001_3 - 0.0029 16.7 0.0 0.0092 15.0 0.0 1.8 1 1 1 2 2 2 1 6-bladed beta-propeller SGL PF08450.10 001357127.1_32929001_3 - 0.0071 15.8 0.0 5.7 6.3 0.0 3.0 3 1 0 3 3 3 2 SMP-30/Gluconolaconase/LRE-like region Motilin_ghrelin PF04644.10 001357127.1_32929001_3 - 0.0081 15.9 1.6 0.017 14.8 1.6 1.5 1 0 0 1 1 1 1 Motilin/ghrelin An_peroxidase PF03098.13 001081775.2_21027001_1 - 4.4e-55 187.1 0.0 6.6e-47 160.1 0.1 2.2 1 1 1 2 2 2 2 Animal haem peroxidase EGF PF00008.25 001081775.2_21027001_1 - 2.9e-05 24.2 12.0 6.1e-05 23.1 12.0 1.6 1 0 0 1 1 1 1 EGF-like domain Histone_H2A_C PF16211.3 001315492.1_45721001_2 - 1.3e-20 72.7 1.2 2.2e-20 72.0 1.2 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.22 001315492.1_45721001_2 - 1.8e-16 60.6 0.0 2.6e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 001315492.1_45721001_2 - 5.4e-05 23.3 0.0 7.6e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone fn2 PF00040.17 001301682.1_32922001_2 - 2e-25 88.6 26.3 4.9e-15 55.4 10.1 2.4 2 0 0 2 2 2 2 Fibronectin type II domain UBA_4 PF14555.4 001301682.1_32922001_3 - 0.085 12.5 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 UBA-like domain zf-C3HC4_4 PF15227.4 001302402.1_39722001_1 - 1.6e-14 53.6 1.6 1.6e-14 53.6 1.6 3.2 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 001302402.1_39722001_1 - 1.7e-10 40.6 1.0 1.7e-10 40.6 1.0 2.7 3 0 0 3 3 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001302402.1_39722001_1 - 1.1e-09 37.9 1.2 1.1e-09 37.9 1.2 2.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001302402.1_39722001_1 - 1.4e-09 37.5 0.9 1.4e-09 37.5 0.9 3.0 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001302402.1_39722001_1 - 5e-09 36.0 2.6 5e-09 36.0 2.6 3.4 4 0 0 4 4 4 1 B-box zinc finger zf-C3HC4_3 PF13920.4 001302402.1_39722001_1 - 2.3e-06 27.2 12.1 4.9e-06 26.2 1.0 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001302402.1_39722001_1 - 4.9e-06 26.6 2.0 4.9e-06 26.6 2.0 3.3 3 1 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.4 001302402.1_39722001_1 - 0.00024 20.8 11.9 0.0004 20.2 0.7 3.6 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_10 PF16685.3 001302402.1_39722001_1 - 0.0031 17.5 10.2 0.024 14.6 1.5 3.2 3 0 0 3 3 3 2 zinc RING finger of MSL2 zf-H2C2_2 PF13465.4 001302402.1_39722001_1 - 0.0055 17.0 1.4 0.028 14.7 0.3 2.4 2 0 0 2 2 2 1 Zinc-finger double domain zf-RING_6 PF14835.4 001302402.1_39722001_1 - 0.012 15.3 0.7 0.033 13.9 0.7 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 001302402.1_39722001_1 - 0.017 14.8 2.2 0.017 14.8 2.2 3.3 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 zf-Di19 PF05605.10 001302402.1_39722001_1 - 0.32 11.2 10.6 0.32 11.2 0.2 3.3 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding IBR PF01485.19 001302402.1_39722001_1 - 0.44 10.7 14.3 1.4 9.1 1.8 3.5 3 1 0 3 3 3 0 IBR domain, a half RING-finger domain zf-RING_11 PF17123.3 001302402.1_39722001_1 - 0.81 9.3 7.6 0.65 9.6 4.8 2.2 2 0 0 2 2 2 0 RING-like zinc finger Nop14 PF04147.10 001302402.1_39722001_1 - 0.86 7.6 5.6 1.1 7.2 5.6 1.2 1 0 0 1 1 1 0 Nop14-like family Aldolase_II PF00596.19 001320591.1_26229001_3 - 5.4e-39 133.9 0.1 7.7e-39 133.4 0.1 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Pkinase_Tyr PF07714.15 001190173.1_49826001_3 - 7.8e-88 294.0 0.0 1e-87 293.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001190173.1_49826001_3 - 2.2e-44 151.7 0.0 3.4e-44 151.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001190173.1_49826001_3 - 4.5e-24 84.2 0.0 8.2e-24 83.3 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001190173.1_49826001_3 - 3.1e-13 49.0 0.0 5.2e-13 48.2 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001190173.1_49826001_3 - 6.5e-08 32.2 0.0 1.3e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001190173.1_49826001_3 - 2.3e-06 27.1 0.0 4.4e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain APH PF01636.21 001190173.1_49826001_3 - 0.072 12.9 0.0 0.28 11.0 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family MatE PF01554.16 001191920.1_45724001_1 - 3.8e-61 205.3 25.3 1.7e-32 112.2 10.2 2.8 4 0 0 4 4 4 2 MatE Polysacc_synt_C PF14667.4 001191920.1_45724001_1 - 9.9e-06 25.5 24.4 0.00012 22.0 11.8 4.5 4 2 1 5 5 5 2 Polysaccharide biosynthesis C-terminal domain DUF3341 PF11821.6 001191920.1_45724001_1 - 0.4 10.2 0.0 0.4 10.2 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3341) Trypan_PARP PF05887.9 001191100.1_45726001_1 - 2.3 8.1 4.4 4.1 7.3 4.4 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) RRM_1 PF00076.20 001191100.1_45726001_2 - 3.9e-17 61.7 0.0 8.7e-17 60.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001191100.1_45726001_2 - 0.0028 17.6 0.0 0.0053 16.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif Glyco_hydro_47 PF01532.18 001191671.1_45726001_2 - 1.7e-115 386.4 0.0 3.2e-115 385.5 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 PA PF02225.20 001191671.1_45726001_2 - 2.3e-12 46.7 0.0 4.8e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 PA domain Glyco_hydro_127 PF07944.10 001191671.1_45726001_2 - 0.16 10.3 0.0 0.25 9.6 0.0 1.2 1 0 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 TUDOR PF00567.22 001191971.1_45727001_2 - 2.1e-25 88.9 0.0 5.3e-25 87.7 0.0 1.7 1 0 0 1 1 1 1 Tudor domain Pkinase PF00069.23 001191971.1_45727001_2 - 3.1e-16 59.4 0.0 9.1e-16 57.9 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001191971.1_45727001_2 - 7e-09 35.2 0.0 1.7e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Agenet PF05641.10 001191971.1_45727001_2 - 0.00037 20.8 0.0 0.001 19.4 0.0 1.7 1 0 0 1 1 1 1 Agenet domain DUF4047 PF13256.4 001191971.1_45727001_2 - 4.7 7.3 13.0 0.34 11.0 1.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4047) Amino_oxidase PF01593.22 001185170.1_49825001_2 - 3.8e-74 250.5 0.0 2.8e-47 161.9 0.0 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 001185170.1_49825001_2 - 8.5e-15 54.6 0.8 1.8e-14 53.6 0.8 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001185170.1_49825001_2 - 1.7e-06 27.8 0.4 3.6e-06 26.7 0.1 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 001185170.1_49825001_2 - 6.8e-06 25.3 2.6 1e-05 24.7 2.6 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.12 001185170.1_49825001_2 - 0.00081 18.6 0.1 0.0016 17.6 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.25 001185170.1_49825001_2 - 0.0013 19.2 0.7 0.0037 17.7 0.7 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.17 001185170.1_49825001_2 - 0.0013 18.0 2.4 0.0026 16.9 0.7 1.9 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.12 001185170.1_49825001_2 - 0.0017 17.0 0.2 0.003 16.2 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.5 001185170.1_49825001_2 - 0.0026 17.0 0.4 0.0035 16.6 0.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.15 001185170.1_49825001_2 - 0.0042 16.2 0.3 0.0071 15.5 0.3 1.2 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.19 001185170.1_49825001_2 - 0.0045 16.2 0.1 0.0071 15.5 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.10 001185170.1_49825001_2 - 0.0089 15.0 0.5 0.074 11.9 0.6 1.9 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.4 001185170.1_49825001_2 - 0.012 14.7 0.7 0.018 14.2 0.3 1.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.18 001185170.1_49825001_2 - 0.013 15.5 0.1 0.022 14.7 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GIDA PF01134.20 001185170.1_49825001_2 - 0.019 13.9 1.3 0.027 13.4 1.3 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A MCRA PF06100.9 001185170.1_49825001_2 - 0.032 12.9 0.0 0.049 12.3 0.0 1.3 1 0 0 1 1 1 0 MCRA family FMO-like PF00743.17 001185170.1_49825001_2 - 0.056 11.7 0.0 0.076 11.3 0.0 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.4 001185170.1_49825001_2 - 0.073 12.9 0.7 0.13 12.1 0.3 1.6 2 0 0 2 2 1 0 FAD-NAD(P)-binding ABC_tran PF00005.25 001106020.2_45729001_1 - 1.9e-52 177.3 0.0 2.1e-28 99.4 0.1 3.0 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.5 001106020.2_45729001_1 - 1.8e-47 162.0 42.0 2e-28 99.4 17.0 3.0 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.4 001106020.2_45729001_1 - 1.5e-17 64.3 15.0 2.7e-05 24.0 0.0 6.7 6 0 0 6 6 6 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001106020.2_45729001_1 - 0.00029 20.4 4.0 0.012 15.1 0.3 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.4 001106020.2_45729001_1 - 0.0082 16.5 7.9 0.011 16.1 0.1 3.6 3 0 0 3 3 3 1 AAA domain DUF258 PF03193.14 001106020.2_45729001_1 - 0.043 13.6 0.6 0.46 10.2 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function, DUF258 FBA PF04300.11 001106020.2_45729001_1 - 0.059 13.1 1.0 0.37 10.5 0.0 2.6 3 0 0 3 3 3 0 F-box associated region SMC_N PF02463.17 001106020.2_45729001_1 - 0.11 11.8 0.3 1.3 8.3 0.0 2.8 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.10 001106020.2_45729001_1 - 0.12 11.5 0.0 3.9 6.6 0.0 3.0 3 0 0 3 3 3 0 Zeta toxin AAA_22 PF13401.4 001106020.2_45729001_1 - 0.18 12.0 0.5 6.4 6.9 0.0 4.0 4 0 0 4 4 4 0 AAA domain CENP-R PF06729.10 001106020.2_45729001_1 - 0.19 11.5 2.1 0.22 11.3 0.1 2.1 2 0 0 2 2 2 0 Kinetochore component, CENP-R SUIM_assoc PF16619.3 001204181.1_49829001_1 - 1.7 8.7 11.6 0.44 10.5 6.2 2.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Katanin_con80 PF13925.4 001190181.1_49826001_2 - 2.7e-41 141.1 0.2 5e-41 140.3 0.2 1.4 1 0 0 1 1 1 1 con80 domain of Katanin Forkhead PF00250.16 001168584.1_45723001_1 - 3.7e-34 116.8 0.0 5.6e-34 116.2 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain DUF2360 PF10152.7 001168584.1_45723001_1 - 2.8 8.2 4.8 7.6 6.8 4.8 1.7 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) SDF PF00375.16 001164649.1_49829001_1 - 3.4e-132 441.0 30.4 4.1e-132 440.7 30.4 1.1 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family 7tm_1 PF00001.19 001206457.1_49823001_1 - 3.1e-57 193.7 9.6 3.1e-57 193.7 9.6 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001206457.1_49823001_1 - 1e-09 38.1 3.4 2.3e-09 36.9 3.4 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001206457.1_49823001_1 - 8.2e-05 22.3 10.2 0.00017 21.3 10.2 1.6 1 1 0 1 1 1 1 Olfactory receptor DUF420 PF04238.10 001206457.1_49823001_1 - 0.0056 16.8 2.9 0.0056 16.8 2.9 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF420) SUR7 PF06687.10 001206457.1_49823001_1 - 4.1 6.8 16.2 0.36 10.3 3.3 2.9 3 0 0 3 3 3 0 SUR7/PalI family CH PF00307.29 001243882.1_49829001_3 - 1.8e-43 147.1 0.2 2.2e-20 72.7 0.0 2.4 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001243882.1_49829001_3 - 2.9e-06 26.9 0.0 0.0026 17.4 0.0 2.5 2 0 0 2 2 2 2 CAMSAP CH domain NAP PF00956.16 001244090.1_49826001_3 - 2.5e-38 131.7 12.9 5.7e-33 114.1 4.1 2.6 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Phage_Mu_Gam PF07352.10 001244090.1_49826001_3 - 0.018 14.8 2.6 0.036 13.8 2.6 1.5 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein ZapB PF06005.10 001244090.1_49826001_3 - 0.42 11.0 5.0 0.99 9.8 5.0 1.5 1 0 0 1 1 1 0 Cell division protein ZapB OmpH PF03938.12 001244090.1_49826001_3 - 1.3 8.8 6.0 2.7 7.8 6.0 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Basic PF01586.14 001244672.1_49823001_3 - 1.3e-22 80.6 0.0 3.7e-22 79.2 0.0 1.8 1 0 0 1 1 1 1 Myogenic Basic domain HLH PF00010.24 001244672.1_49823001_3 - 7.4e-13 48.1 6.3 1.2e-12 47.4 6.3 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Myf5 PF12232.6 001244672.1_49823001_3 - 0.002 18.7 1.5 0.002 18.7 1.5 1.9 2 0 0 2 2 2 1 Myogenic determination factor 5 CAP_N PF01213.17 001244672.1_49823001_3 - 0.038 13.3 1.2 0.08 12.3 1.2 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Na_Ca_ex PF01699.22 001244595.1_49825001_3 - 4e-61 205.3 47.8 7e-32 110.4 20.6 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein SIT PF15330.4 001244595.1_49825001_3 - 7.4 6.9 5.6 1.4e+02 2.7 0.0 3.5 3 0 0 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT C1q PF00386.19 001244702.1_49826001_1 - 2.7e-26 92.1 0.3 3.8e-26 91.6 0.3 1.2 1 0 0 1 1 1 1 C1q domain CDP-OH_P_transf PF01066.19 001244662.1_49823001_3 - 2.9e-17 63.0 0.1 2.9e-17 63.0 0.1 3.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase TPR_MLP1_2 PF07926.10 001205623.1_06529001_1 - 2.1e-34 118.3 28.7 2.1e-34 118.3 28.7 16.5 8 4 8 16 16 16 8 TPR/MLP1/MLP2-like protein Seryl_tRNA_N PF02403.20 001205623.1_06529001_1 - 0.0028 17.7 15.8 0.0028 17.7 15.8 18.1 6 3 10 19 19 19 1 Seryl-tRNA synthetase N-terminal domain WD40 PF00400.30 001192340.1_06523001_1 - 8.7e-16 57.9 2.2 0.0042 17.8 0.0 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001192340.1_06523001_1 - 8.6e-06 25.8 0.0 0.034 14.3 0.0 2.9 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Med23 PF11573.6 001205762.1_06529001_1 - 0 2050.0 7.6 0 2049.8 7.6 1.0 1 0 0 1 1 1 1 Mediator complex subunit 23 7tm_3 PF00003.20 001099503.1_45726001_1 - 2.1e-57 194.5 29.8 3.6e-57 193.7 29.8 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 001099503.1_45726001_1 - 8.8e-21 73.5 9.5 1.9e-20 72.5 9.5 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR ANF_receptor PF01094.26 001099503.1_45726001_1 - 5.5e-17 61.8 0.0 8e-17 61.2 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Transposase_22 PF02994.12 001099503.1_45726001_1 - 1.6e-13 50.1 6.8 5.8e-13 48.3 6.8 1.7 1 1 0 1 1 1 1 L1 transposable element ERM PF00769.17 001099503.1_45726001_1 - 0.0027 17.4 3.6 0.0044 16.7 3.6 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Apolipoprotein PF01442.16 001099503.1_45726001_1 - 0.025 14.3 4.0 0.045 13.5 4.0 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain IclR PF01614.16 001099503.1_45726001_1 - 0.1 12.3 0.5 0.28 10.9 0.5 1.6 1 0 0 1 1 1 0 Bacterial transcriptional regulator PKK PF12474.6 001099503.1_45726001_1 - 0.14 12.1 9.9 0.24 11.3 9.9 1.2 1 0 0 1 1 1 0 Polo kinase kinase DUF4446 PF14584.4 001099503.1_45726001_1 - 2.3 8.1 5.0 1 9.2 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Brr6_like_C_C PF10104.7 001099503.1_45726001_1 - 2.8 7.6 6.9 0.19 11.3 0.5 2.5 2 0 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain 7tm_3 PF00003.20 001099655.1_45726001_1 - 9.8e-57 192.3 31.4 9.8e-57 192.3 31.4 1.9 3 0 0 3 3 3 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099655.1_45726001_1 - 1.2e-31 110.0 0.9 2e-31 109.3 0.9 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099655.1_45726001_1 - 3.7e-18 65.1 13.3 1e-17 63.7 13.3 1.8 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR DUF4231 PF14015.4 001099655.1_45726001_1 - 3.7 7.9 7.4 2.5 8.5 2.5 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) DUF1673 PF07895.9 001099655.1_45726001_1 - 7.9 6.0 16.4 11 5.5 8.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1673) 7tm_3 PF00003.20 001099486.1_45726001_1 - 1.4e-59 201.6 25.3 2.9e-59 200.6 25.3 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099486.1_45726001_1 - 5.5e-28 97.9 1.4 1.7e-27 96.4 1.4 1.6 1 1 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099486.1_45726001_1 - 6.5e-18 64.3 13.9 1.5e-17 63.2 13.9 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR STAS PF01740.19 001099486.1_45726001_1 - 0.11 12.0 0.0 0.78 9.3 0.0 2.2 2 0 0 2 2 2 0 STAS domain Sortilin-Vps10 PF15902.3 001191207.2_06528001_1 - 1.8e-106 356.5 0.0 2.7e-106 355.9 0.0 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.3 001191207.2_06528001_1 - 7.8e-37 127.1 7.8 1.4e-36 126.3 7.8 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal PKD PF00801.18 001191207.2_06528001_1 - 2e-09 37.0 3.6 4.8e-07 29.4 0.1 2.6 2 0 0 2 2 2 2 PKD domain BNR_6 PF15899.3 001191207.2_06528001_1 - 0.012 15.4 0.6 0.93 9.6 0.0 3.4 3 0 0 3 3 3 0 BNR-Asp box repeat BNR PF02012.18 001191207.2_06528001_1 - 0.044 13.6 13.7 3.7 7.8 0.5 5.8 5 0 0 5 5 5 0 BNR/Asp-box repeat UDPGT PF00201.16 001135869.1_45724001_1 - 1.8e-231 769.1 0.3 2.1e-231 768.9 0.3 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001135869.1_45724001_1 - 1.3e-07 31.6 0.0 2.4e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Pro_3_hydrox_C PF05373.9 001135869.1_45724001_1 - 0.0085 16.0 0.0 0.045 13.7 0.0 2.1 2 0 0 2 2 2 1 L-proline 3-hydroxylase, C-terminal Glyco_trans_1_3 PF13528.4 001135869.1_45724001_1 - 0.045 12.9 0.0 0.62 9.1 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 1 S1FA PF04689.11 001135869.1_45724001_1 - 0.13 12.3 0.1 0.24 11.4 0.1 1.4 1 0 0 1 1 1 0 DNA binding protein S1FA Serpin PF00079.18 001134409.1_45723001_1 - 3.5e-110 368.7 11.2 4.1e-110 368.5 11.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RRM_1 PF00076.20 001205237.1_29628001_3 - 1.4e-08 34.3 0.0 0.0018 17.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001205237.1_29628001_3 - 3.8e-05 23.1 0.1 0.023 14.1 0.0 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_jaz PF12171.6 001205237.1_29628001_3 - 0.028 14.6 8.8 1.3 9.3 1.1 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding CTNNB1_binding PF08347.9 001191052.1_45729001_2 - 2.9e-99 331.1 3.6 2.9e-99 331.1 3.6 2.1 2 0 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.17 001191052.1_45729001_2 - 9.5e-22 77.1 1.0 1.7e-21 76.3 1.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001191052.1_45729001_2 - 7.6e-08 32.7 2.0 1.7e-07 31.6 2.0 1.5 1 0 0 1 1 1 1 HMG-box domain Prp18 PF02840.13 138523.2_45729001_3 - 3.8e-62 208.4 0.2 6.2e-62 207.8 0.2 1.3 1 0 0 1 1 1 1 Prp18 domain PRP4 PF08799.9 138523.2_45729001_3 - 1.8e-13 49.6 7.5 4e-12 45.3 3.1 3.3 3 0 0 3 3 3 2 pre-mRNA processing factor 4 (PRP4) like SapB_1 PF05184.13 001144850.1_45726001_1 - 3.5e-25 87.5 3.2 3.2e-12 46.1 0.6 5.0 5 0 0 5 5 5 4 Saposin-like type B, region 1 SapA PF02199.13 001144850.1_45726001_1 - 4e-25 87.5 27.8 3.5e-14 52.5 2.6 4.1 4 0 0 4 4 4 2 Saposin A-type domain SapB_2 PF03489.15 001144850.1_45726001_1 - 1.4e-21 76.1 11.8 2.5e-09 37.0 1.1 5.3 4 1 0 4 4 4 3 Saposin-like type B, region 2 Histidinol_dh PF00815.18 001144850.1_45726001_1 - 0.12 11.2 0.0 0.19 10.6 0.0 1.1 1 0 0 1 1 1 0 Histidinol dehydrogenase 7tm_4 PF13853.4 001001365.1_45722001_1 - 8.8e-45 153.4 20.4 1.2e-44 153.0 20.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001001365.1_45722001_1 - 2.4e-24 85.9 23.7 5.8e-24 84.6 23.7 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001001365.1_45722001_1 - 3.2e-06 26.6 24.9 4.7e-06 26.0 24.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Polysacc_synt_C PF14667.4 001001365.1_45722001_1 - 0.0096 15.9 2.4 0.0096 15.9 2.4 2.7 2 1 0 2 2 2 1 Polysaccharide biosynthesis C-terminal domain MHC_I PF00129.16 001079819.1_32323001_1 - 1.1e-73 246.4 4.7 1.5e-73 246.0 4.7 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001079819.1_32323001_1 - 1e-15 57.8 0.0 3.8e-15 56.0 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001079819.1_32323001_1 - 1.6e-13 50.1 4.5 3.7e-13 49.0 4.5 1.6 1 0 0 1 1 1 1 MHC_I C-terminus MHC_I_3 PF16497.3 001079819.1_32323001_1 - 2.1e-06 27.3 0.0 4.4e-06 26.2 0.0 1.4 1 1 0 1 1 1 1 MHC-I family domain C2-set_2 PF08205.10 001079819.1_32323001_1 - 0.00057 19.8 0.1 0.0018 18.2 0.0 1.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 001079819.1_32323001_1 - 0.0012 19.2 0.0 0.0039 17.6 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001079819.1_32323001_1 - 0.0033 17.6 0.0 0.0095 16.1 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain MHC_I_2 PF14586.4 001079819.1_32323001_1 - 0.13 12.0 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2 EphA2_TM PF14575.4 001079819.1_32323001_1 - 0.14 12.8 0.3 0.44 11.2 0.0 1.9 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TAS2R PF05296.11 001039860.1_32322001_1 - 2.5e-84 282.8 42.3 2.8e-84 282.7 42.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) YqzM PF14141.4 001039860.1_32322001_1 - 0.038 13.9 3.4 0.14 12.1 3.4 2.0 1 0 0 1 1 1 0 YqzM-like protein DUF4501 PF14946.4 001039860.1_32322001_1 - 0.92 9.4 4.8 1.2 9.1 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4501) BTB PF00651.29 001100996.2_45724001_1 - 3.9e-23 81.6 0.3 2.6e-22 79.0 0.1 2.1 1 1 1 2 2 2 1 BTB/POZ domain 7tm_4 PF13853.4 001000835.1_45722001_1 - 2.3e-52 178.3 18.4 2.8e-52 178.0 18.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001000835.1_45722001_1 - 6.5e-21 74.6 23.0 1.9e-20 73.1 23.0 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-RING_2 PF13639.4 001270724.1_08023001_1 - 8.1e-13 48.3 7.5 1.9e-12 47.1 7.5 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001270724.1_08023001_1 - 1.6e-08 34.1 8.1 3.5e-08 33.0 8.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 001270724.1_08023001_1 - 2.6e-08 33.3 4.1 5.5e-08 32.3 4.1 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.5 001270724.1_08023001_1 - 4.6e-08 33.1 5.9 8.7e-08 32.2 5.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 001270724.1_08023001_1 - 6.3e-08 32.2 6.2 1.3e-07 31.2 6.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001270724.1_08023001_1 - 2.8e-07 30.3 8.7 6.1e-07 29.2 8.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain PA PF02225.20 001270724.1_08023001_1 - 1.3e-06 28.3 0.0 1.9e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 PA domain zf-C3HC4_3 PF13920.4 001270724.1_08023001_1 - 5.9e-05 22.7 7.2 0.00013 21.7 7.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001270724.1_08023001_1 - 9e-05 22.3 5.1 0.00019 21.2 5.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.4 001270724.1_08023001_1 - 0.0032 17.2 8.6 0.008 15.9 8.6 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 001270724.1_08023001_1 - 0.0087 16.0 4.8 0.02 14.8 4.8 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zinc_ribbon_16 PF17034.3 001270724.1_08023001_1 - 0.036 14.1 2.1 0.067 13.3 2.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon like family Zn_ribbon_17 PF17120.3 001270724.1_08023001_1 - 0.07 12.6 6.0 0.13 11.7 6.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PHD PF00628.27 001270724.1_08023001_1 - 2.3 8.0 8.3 4.5 7.1 8.3 1.5 1 0 0 1 1 1 0 PHD-finger 7tm_4 PF13853.4 001270932.1_08023001_3 - 4.7e-50 170.8 25.2 6e-50 170.4 25.2 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001270932.1_08023001_3 - 3.2e-22 78.9 32.8 4.6e-21 75.1 32.8 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SPRY PF00622.26 212488.1_45724001_1 - 1.2e-16 60.8 1.8 1.9e-16 60.1 0.4 2.0 2 0 0 2 2 2 1 SPRY domain V-set PF07686.15 212488.1_45724001_1 - 7.1e-14 51.7 0.0 3.3e-13 49.6 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 212488.1_45724001_1 - 1.5e-07 31.8 0.0 0.00025 21.5 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain PRY PF13765.4 212488.1_45724001_1 - 1.3e-06 27.7 0.1 3.9e-06 26.2 0.1 1.9 1 0 0 1 1 1 1 SPRY-associated domain I-set PF07679.14 212488.1_45724001_1 - 2.6e-06 27.3 0.1 0.0013 18.6 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin I-set domain C2-set_2 PF08205.10 212488.1_45724001_1 - 0.00055 19.8 0.1 0.0021 17.9 0.1 2.0 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 212488.1_45724001_1 - 0.0041 17.1 1.7 0.048 13.7 0.0 3.1 2 2 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 212488.1_45724001_1 - 0.038 14.2 0.0 4.8 7.5 0.0 2.9 2 1 0 2 2 2 0 Immunoglobulin domain C1-set PF07654.13 212488.1_45724001_1 - 0.039 14.3 0.1 0.56 10.6 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin C1-set domain TAS2R PF05296.11 001039851.1_32322001_1 - 4.5e-81 272.1 35.6 5e-81 272.0 35.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TAS2R PF05296.11 001039852.1_32322001_1 - 3.8e-75 252.7 32.8 4.3e-75 252.5 32.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TAS2R PF05296.11 001039853.1_32322001_1 - 6.6e-85 284.7 34.3 7.3e-85 284.6 34.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TAS2R PF05296.11 001039854.1_32322001_1 - 1.9e-76 256.9 29.2 2.2e-76 256.8 29.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TAS2R PF05296.11 001039857.1_32322001_1 - 7.2e-84 281.3 44.4 8.1e-84 281.2 44.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TAS2R PF05296.11 001039858.1_32322001_1 - 1.9e-89 299.7 20.4 2.1e-89 299.5 20.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TAS2R PF05296.11 001039859.1_32322001_1 - 1.2e-84 283.8 34.6 1.4e-84 283.7 34.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001039859.1_32322001_1 - 0.6 9.2 16.4 0.84 8.7 16.4 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001039861.1_32322001_1 - 3.5e-91 305.3 27.0 4e-91 305.1 27.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Vma12 PF11712.6 001039861.1_32322001_1 - 0.083 12.8 1.0 0.11 12.3 0.0 1.7 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase TAS2R PF05296.11 001039862.1_32322001_1 - 2.8e-108 361.4 32.0 3.2e-108 361.3 32.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) UPF0182 PF03699.11 001039862.1_32322001_1 - 2 6.3 15.7 2.7 5.9 15.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) TAS2R PF05296.11 001039863.1_32322001_1 - 2.5e-90 302.5 28.9 2.8e-90 302.3 28.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TAS2R PF05296.11 001039864.1_32322001_1 - 8.2e-88 294.3 32.3 9.2e-88 294.1 32.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TAS2R PF05296.11 001039865.1_32322001_1 - 2.6e-97 325.5 39.3 2.9e-97 325.3 39.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF2953 PF11167.6 001039865.1_32322001_1 - 0.049 13.6 0.6 0.2 11.6 0.6 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2953) TAS2R PF05296.11 001039867.1_32322001_1 - 7.9e-91 304.2 39.1 9e-91 304.0 39.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TAS2R PF05296.11 001039868.1_32322001_1 - 1.8e-96 322.7 29.0 2e-96 322.5 29.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TAS2R PF05296.11 001039869.1_32322001_1 - 2.5e-106 355.1 25.7 2.8e-106 354.9 25.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Gate PF07670.12 001039869.1_32322001_1 - 0.0043 17.2 2.9 0.0043 17.2 2.9 2.3 3 0 0 3 3 3 1 Nucleoside recognition 7tm_1 PF00001.19 001039869.1_32322001_1 - 2.7 7.0 12.3 5.2 6.1 12.3 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001039870.1_32322001_1 - 1.3e-91 306.8 29.4 1.4e-91 306.6 29.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) E1-E2_ATPase PF00122.18 001039870.1_32322001_1 - 0.99 8.5 5.9 0.27 10.4 1.7 2.1 1 1 1 2 2 2 0 E1-E2 ATPase TAS2R PF05296.11 001039871.1_32322001_1 - 8.7e-83 277.8 38.8 9.8e-83 277.6 38.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Popeye PF04831.11 001039871.1_32322001_1 - 0.059 13.4 0.6 0.059 13.4 0.6 2.9 2 2 1 3 3 3 0 Popeye protein conserved region TAS2R PF05296.11 001039872.1_32322001_1 - 1.9e-79 266.8 29.3 2.2e-79 266.6 29.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) VIT1 PF01988.17 001039872.1_32322001_1 - 2 8.1 6.9 2.3 7.9 0.3 2.2 1 1 1 2 2 2 0 VIT family Meth_synt_1 PF08267.10 001039872.1_32322001_3 - 0.12 11.8 0.2 0.15 11.4 0.2 1.1 1 0 0 1 1 1 0 Cobalamin-independent synthase, N-terminal domain TAS2R PF05296.11 001039874.1_32322001_1 - 7.9e-81 271.3 33.5 9.5e-81 271.1 33.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) CTNNB1_binding PF08347.9 001039874.1_32322001_3 - 0.031 14.3 0.7 0.04 14.0 0.7 1.2 1 0 0 1 1 1 0 N-terminal CTNNB1 binding TAS2R PF05296.11 001039875.1_32322001_1 - 7.5e-93 310.8 31.9 8.6e-93 310.6 31.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Linker_histone PF00538.17 001025216.1_49822001_1 - 2.8e-23 81.9 0.6 2.8e-23 81.9 0.6 2.4 2 0 0 2 2 2 1 linker histone H1 and H5 family 7tm_3 PF00003.20 001099547.1_32325001_1 - 6.1e-66 222.4 19.3 9.8e-66 221.8 19.3 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099547.1_32325001_1 - 2.6e-51 174.7 0.0 3.7e-51 174.1 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099547.1_32325001_1 - 1.4e-15 56.9 12.1 2.7e-15 55.9 12.1 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.11 001099547.1_32325001_1 - 0.064 12.9 6.2 0.17 11.5 6.2 1.7 1 0 0 1 1 1 0 Putative ephrin-receptor like DUF3611 PF12263.6 001099547.1_32325001_1 - 7 6.4 11.0 0.038 13.7 0.8 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3611) 7tm_3 PF00003.20 001099549.1_32325001_1 - 7.5e-65 218.9 20.5 1.3e-64 218.1 20.5 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099549.1_32325001_1 - 3.5e-49 167.6 0.0 5e-49 167.1 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099549.1_32325001_1 - 4.1e-17 61.8 12.7 7.5e-17 60.9 12.7 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Metallophos_3 PF14582.4 001099549.1_32325001_1 - 0.041 13.1 0.0 0.088 12.0 0.0 1.5 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily Ephrin_rec_like PF07699.11 001099549.1_32325001_1 - 0.05 13.3 7.4 0.13 12.0 7.4 1.6 1 0 0 1 1 1 0 Putative ephrin-receptor like 7tm_3 PF00003.20 001099554.1_32325001_1 - 5.6e-66 222.5 21.7 9.9e-66 221.7 21.7 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099554.1_32325001_1 - 1e-48 166.1 0.1 1.5e-48 165.6 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099554.1_32325001_1 - 8e-17 60.8 11.5 1.7e-16 59.8 11.5 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.11 001099554.1_32325001_1 - 0.046 13.4 7.8 0.13 11.9 7.8 1.7 1 0 0 1 1 1 0 Putative ephrin-receptor like DUF5080 PF16883.3 001099554.1_32325001_1 - 0.07 13.1 1.5 0.17 11.9 1.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5080) RexB PF15968.3 001099554.1_32325001_1 - 2 8.8 7.4 0.22 11.9 2.0 2.1 1 1 0 2 2 2 0 Membrane-anchored ion channel, Abi component 7tm_3 PF00003.20 001099591.1_32325001_1 - 8.8e-67 225.2 21.8 1.6e-66 224.3 21.8 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099591.1_32325001_1 - 8.8e-49 166.3 0.0 1.3e-48 165.8 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099591.1_32325001_1 - 3.2e-16 58.9 11.3 6e-16 58.0 11.3 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.11 001099591.1_32325001_1 - 0.03 14.0 7.3 0.073 12.7 7.3 1.6 1 0 0 1 1 1 0 Putative ephrin-receptor like DUF5080 PF16883.3 001099591.1_32325001_1 - 0.044 13.8 0.9 0.12 12.3 0.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5080) 7tm_3 PF00003.20 001099563.1_32326001_1 - 1.6e-61 208.0 28.6 6.6e-61 206.0 26.6 2.3 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099563.1_32326001_1 - 2.2e-53 181.5 0.0 2.9e-53 181.1 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099563.1_32326001_1 - 1.1e-18 66.8 11.5 2.2e-18 65.8 11.5 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR 7tm_3 PF00003.20 001099568.1_32325001_1 - 8.2e-61 205.6 25.1 8.2e-61 205.6 25.1 1.8 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099568.1_32325001_1 - 6.1e-57 193.2 0.0 8e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099568.1_32325001_1 - 9.2e-17 60.6 22.4 2.1e-16 59.5 22.4 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR DUF4275 PF14101.4 001099568.1_32325001_1 - 0.13 12.3 0.1 0.25 11.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4275) 7tm_3 PF00003.20 001099526.1_32326001_1 - 2.7e-64 217.0 23.7 4.9e-64 216.2 23.7 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099526.1_32326001_1 - 2.5e-45 155.0 0.0 3.4e-45 154.6 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099526.1_32326001_1 - 1e-19 70.1 10.9 2.4e-19 68.9 10.9 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001099526.1_32326001_1 - 0.0048 16.5 0.0 0.0079 15.8 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein Ephrin_rec_like PF07699.11 001099526.1_32326001_1 - 0.55 9.9 4.3 1.8 8.3 4.3 1.9 1 0 0 1 1 1 0 Putative ephrin-receptor like TNFR_c6 PF00020.16 001099526.1_32326001_1 - 5 7.5 8.4 9.1 6.7 3.1 2.9 1 1 0 2 2 2 0 TNFR/NGFR cysteine-rich region 7tm_3 PF00003.20 001099528.1_32326001_1 - 5.6e-61 206.2 22.9 1.1e-60 205.3 22.9 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099528.1_32326001_1 - 4.6e-50 170.6 0.0 6.3e-50 170.1 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099528.1_32326001_1 - 3.3e-20 71.7 13.6 6.9e-20 70.6 13.6 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR 7tm_3 PF00003.20 001099535.1_32325001_1 - 6.5e-65 219.1 21.2 1e-64 218.4 21.2 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099535.1_32325001_1 - 1e-51 176.0 0.0 1.5e-51 175.5 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099535.1_32325001_1 - 1.5e-20 72.8 12.2 3e-20 71.8 12.2 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.11 001099535.1_32325001_1 - 0.0044 16.6 1.2 0.0044 16.6 1.2 2.0 1 1 1 2 2 2 1 Putative ephrin-receptor like 7tm_3 PF00003.20 001099537.1_32326001_1 - 2.7e-64 217.0 24.1 5.5e-64 216.0 24.1 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099537.1_32326001_1 - 4.3e-52 177.2 0.0 5.8e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099537.1_32326001_1 - 6.4e-20 70.7 12.3 1.2e-19 69.8 12.3 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001099537.1_32326001_1 - 0.076 12.6 0.0 0.17 11.4 0.0 1.5 2 0 0 2 2 2 0 Periplasmic binding protein 7tm_3 PF00003.20 001099539.1_32325001_1 - 9.6e-63 212.0 24.5 1.5e-62 211.3 24.5 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099539.1_32325001_1 - 8e-53 179.6 0.0 1.1e-52 179.2 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099539.1_32325001_1 - 2.4e-19 68.9 11.5 5.2e-19 67.8 11.5 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR 7tm_3 PF00003.20 001099542.1_32326001_1 - 1.8e-64 217.6 25.0 3.3e-64 216.8 25.0 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099542.1_32326001_1 - 9.3e-55 186.0 0.0 1.2e-54 185.6 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099542.1_32326001_1 - 3.1e-19 68.6 11.2 6.8e-19 67.5 11.2 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001099542.1_32326001_1 - 0.016 14.8 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein TNFR_c6 PF00020.16 001099542.1_32326001_1 - 6.3 7.2 13.0 9.4 6.6 6.9 3.0 1 1 0 2 2 2 0 TNFR/NGFR cysteine-rich region 7tm_3 PF00003.20 001099543.1_32325001_1 - 5.7e-62 209.4 27.3 9.7e-62 208.7 27.3 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099543.1_32325001_1 - 2e-53 181.6 0.0 2.6e-53 181.2 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099543.1_32325001_1 - 2e-18 65.9 12.9 4.4e-18 64.9 12.9 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001099543.1_32325001_1 - 0.0043 16.7 0.0 0.0065 16.1 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein 7tm_3 PF00003.20 001099544.1_32326001_1 - 2.8e-65 220.3 25.6 4.9e-65 219.5 25.6 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099544.1_32326001_1 - 5e-50 170.4 0.1 6.7e-50 170.0 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099544.1_32326001_1 - 7e-19 67.4 13.0 7e-19 67.4 13.0 2.0 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001099544.1_32326001_1 - 0.0068 16.0 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein Vut_1 PF02592.13 001099544.1_32326001_1 - 0.88 9.7 10.0 0.17 12.1 5.0 2.3 1 1 1 2 2 2 0 Putative vitamin uptake transporter 7tm_3 PF00003.20 001099548.1_32325001_1 - 7.6e-66 222.1 21.2 1.3e-65 221.3 21.2 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099548.1_32325001_1 - 2.2e-48 165.0 0.3 3.2e-48 164.5 0.3 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099548.1_32325001_1 - 1e-16 60.5 11.3 2e-16 59.6 11.3 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.11 001099548.1_32325001_1 - 0.02 14.5 7.4 0.052 13.2 7.4 1.7 1 0 0 1 1 1 0 Putative ephrin-receptor like DUF5080 PF16883.3 001099548.1_32325001_1 - 0.026 14.5 0.5 0.062 13.3 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5080) 7tm_3 PF00003.20 001099550.1_32325001_1 - 6.3e-66 222.4 22.3 9.6e-66 221.8 22.3 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099550.1_32325001_1 - 6.6e-54 183.2 0.1 1e-53 182.6 0.1 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region IL6 PF00489.15 001099550.1_32325001_1 - 0.063 12.7 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family DUF5080 PF16883.3 001099550.1_32325001_1 - 0.072 13.1 2.1 0.18 11.8 2.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5080) NCD3G PF07562.12 001099550.1_32325001_1 - 0.094 12.6 0.5 0.2 11.6 0.5 1.5 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR Metallophos_3 PF14582.4 001099550.1_32325001_1 - 0.099 11.8 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily 7tm_3 PF00003.20 001099551.1_32325001_1 - 2e-64 217.5 20.1 3.4e-64 216.7 20.1 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099551.1_32325001_1 - 4e-48 164.2 0.0 6e-48 163.6 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099551.1_32325001_1 - 2.5e-17 62.4 13.2 4.8e-17 61.5 13.2 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Metallophos_3 PF14582.4 001099551.1_32325001_1 - 0.041 13.1 0.0 0.088 12.0 0.0 1.5 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily Ephrin_rec_like PF07699.11 001099551.1_32325001_1 - 0.061 13.0 8.1 0.16 11.6 8.1 1.7 1 0 0 1 1 1 0 Putative ephrin-receptor like 7tm_3 PF00003.20 001099553.1_32325001_1 - 4.1e-64 216.4 20.1 7.8e-64 215.5 20.1 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099553.1_32325001_1 - 3.5e-52 177.5 0.0 5.1e-52 177.0 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099553.1_32325001_1 - 2.5e-17 62.4 13.2 4.7e-17 61.6 13.2 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.11 001099553.1_32325001_1 - 0.047 13.3 7.8 0.12 12.0 7.8 1.7 1 0 0 1 1 1 0 Putative ephrin-receptor like DUF5080 PF16883.3 001099553.1_32325001_1 - 0.055 13.5 1.8 0.14 12.2 1.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5080) 7tm_3 PF00003.20 001099555.1_32326001_1 - 2.7e-65 220.3 21.8 2.7e-65 220.3 21.8 1.9 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099555.1_32326001_1 - 3.9e-46 157.6 0.4 5.6e-46 157.1 0.4 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099555.1_32326001_1 - 1.8e-17 62.9 11.6 4e-17 61.8 11.6 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.11 001099555.1_32326001_1 - 0.42 10.3 6.9 0.99 9.1 6.9 1.6 1 0 0 1 1 1 0 Putative ephrin-receptor like DUF1109 PF06532.9 001099555.1_32326001_1 - 6 6.3 13.8 0.15 11.6 3.5 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1109) 7tm_3 PF00003.20 001099558.1_32326001_1 - 2.2e-60 204.2 24.2 2.2e-60 204.2 24.2 1.6 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099558.1_32326001_1 - 7.3e-50 169.9 0.0 9.9e-50 169.5 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099558.1_32326001_1 - 1.6e-17 63.0 16.4 4.9e-17 61.5 16.4 1.9 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR DUF443 PF04276.10 001099558.1_32326001_1 - 7.5 6.1 10.1 26 4.4 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF443) 7tm_3 PF00003.20 001099564.1_32325001_1 - 1.6e-63 214.5 25.9 1.6e-63 214.5 25.9 1.7 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099564.1_32325001_1 - 2.2e-51 174.9 0.0 2.9e-51 174.5 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099564.1_32325001_1 - 1e-16 60.5 16.6 1e-16 60.5 16.6 1.8 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR Furin-like_2 PF15913.3 001099564.1_32325001_1 - 0.14 12.2 7.2 0.31 11.1 7.2 1.5 1 0 0 1 1 1 0 Furin-like repeat, cysteine-rich 7tm_3 PF00003.20 001099567.1_32326001_1 - 4.6e-60 203.2 25.8 5.4e-60 203.0 23.6 2.0 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099567.1_32326001_1 - 5.2e-54 183.5 0.0 7.3e-54 183.1 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099567.1_32326001_1 - 3e-19 68.6 9.9 7.2e-19 67.4 9.9 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR DUF2157 PF09925.7 001099567.1_32326001_1 - 3 7.5 9.5 5.4 6.7 1.8 2.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) 7tm_3 PF00003.20 001099571.1_32326001_1 - 1.9e-61 207.7 30.4 4.2e-61 206.6 30.4 1.6 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099571.1_32326001_1 - 1.8e-45 155.4 0.0 2.5e-45 155.0 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099571.1_32326001_1 - 6.8e-19 67.5 10.6 1.7e-18 66.2 10.6 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001099571.1_32326001_1 - 1.2e-05 25.0 0.0 2.6e-05 23.9 0.0 1.4 2 0 0 2 2 2 1 Periplasmic binding protein Ephrin_rec_like PF07699.11 001099571.1_32326001_1 - 0.47 10.1 5.7 1 9.0 5.7 1.6 1 0 0 1 1 1 0 Putative ephrin-receptor like 7tm_3 PF00003.20 001099572.1_32325001_1 - 6.5e-64 215.8 28.1 1.6e-63 214.5 28.1 1.7 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099572.1_32325001_1 - 1.4e-45 155.8 0.0 2e-45 155.3 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099572.1_32325001_1 - 6.5e-19 67.5 12.6 1e-18 66.9 11.9 1.7 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001099572.1_32325001_1 - 0.00077 19.1 0.0 0.0012 18.5 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein SP2 PF03014.12 001099572.1_32325001_1 - 0.15 10.0 0.1 0.21 9.4 0.1 1.1 1 0 0 1 1 1 0 Structural protein 2 Ephrin_rec_like PF07699.11 001099572.1_32325001_1 - 0.29 10.8 5.3 0.65 9.7 5.3 1.5 1 0 0 1 1 1 0 Putative ephrin-receptor like 7tm_3 PF00003.20 001099573.1_32325001_1 - 4.2e-60 203.3 29.2 4.2e-60 203.3 29.2 2.3 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099573.1_32325001_1 - 4e-42 144.4 0.0 5.4e-42 144.0 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099573.1_32325001_1 - 6e-17 61.2 11.0 1e-16 60.5 10.4 1.8 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR SP2 PF03014.12 001099573.1_32325001_1 - 0.13 10.1 0.1 0.19 9.6 0.1 1.1 1 0 0 1 1 1 0 Structural protein 2 Ephrin_rec_like PF07699.11 001099573.1_32325001_1 - 0.44 10.2 5.2 0.98 9.1 5.2 1.5 1 0 0 1 1 1 0 Putative ephrin-receptor like 7tm_3 PF00003.20 001099576.1_32325001_1 - 7.3e-61 205.8 32.5 1.9e-60 204.4 32.5 1.7 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099576.1_32325001_1 - 1.5e-39 136.0 0.0 2.1e-39 135.5 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099576.1_32325001_1 - 8.4e-18 64.0 14.9 1.6e-17 63.1 14.3 1.9 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR SP2 PF03014.12 001099576.1_32325001_1 - 0.07 11.0 0.1 0.1 10.5 0.1 1.1 1 0 0 1 1 1 0 Structural protein 2 Ephrin_rec_like PF07699.11 001099576.1_32325001_1 - 0.26 11.0 6.8 0.68 9.6 6.8 1.7 1 0 0 1 1 1 0 Putative ephrin-receptor like 7tm_3 PF00003.20 001099577.1_32326001_1 - 3.1e-60 203.7 27.6 5.3e-60 203.0 27.6 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099577.1_32326001_1 - 3.2e-48 164.5 0.0 4.3e-48 164.1 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099577.1_32326001_1 - 6.4e-18 64.3 15.9 1.4e-17 63.3 15.9 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001099577.1_32326001_1 - 0.052 13.1 0.0 0.087 12.4 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein DUF2157 PF09925.7 001099577.1_32326001_1 - 1.7 8.3 7.8 9.6 5.9 0.9 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) 7tm_3 PF00003.20 001099588.1_32325001_1 - 1.7e-66 224.2 21.3 2.7e-66 223.6 21.3 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099588.1_32325001_1 - 8.3e-49 166.4 0.0 1.2e-48 165.9 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099588.1_32325001_1 - 2.9e-16 59.0 11.2 5.6e-16 58.1 11.2 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.11 001099588.1_32325001_1 - 0.032 13.9 7.4 0.078 12.6 7.4 1.6 1 0 0 1 1 1 0 Putative ephrin-receptor like DUF5080 PF16883.3 001099588.1_32325001_1 - 0.085 12.8 1.6 0.2 11.6 1.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5080) 7tm_3 PF00003.20 001099589.1_32325001_1 - 3.2e-66 223.3 20.5 5e-66 222.7 20.5 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099589.1_32325001_1 - 7.6e-50 169.8 0.1 1.1e-49 169.3 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099589.1_32325001_1 - 1.1e-16 60.4 12.5 2.1e-16 59.5 12.5 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.11 001099589.1_32325001_1 - 0.028 14.1 7.3 0.073 12.7 7.3 1.7 1 0 0 1 1 1 0 Putative ephrin-receptor like 7tm_3 PF00003.20 001099590.1_32325001_1 - 9.3e-66 221.8 21.9 9.3e-66 221.8 21.9 1.5 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099590.1_32325001_1 - 1.3e-50 172.4 0.0 2e-50 171.8 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099590.1_32325001_1 - 2.9e-16 59.0 12.2 5.5e-16 58.2 12.2 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.11 001099590.1_32325001_1 - 0.021 14.4 6.7 0.057 13.1 6.7 1.7 1 0 0 1 1 1 0 Putative ephrin-receptor like DUF2157 PF09925.7 001099590.1_32325001_1 - 0.4 10.3 8.0 2.9 7.5 0.8 2.9 2 1 1 3 3 3 0 Predicted membrane protein (DUF2157) 7tm_3 PF00003.20 001099592.1_32325001_1 - 8.7e-65 218.6 21.4 1.3e-64 218.1 21.4 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099592.1_32325001_1 - 9.8e-50 169.5 0.1 1.5e-49 168.9 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099592.1_32325001_1 - 6.7e-17 61.1 12.1 1.3e-16 60.2 12.1 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Metallophos_3 PF14582.4 001099592.1_32325001_1 - 0.023 13.9 0.0 0.05 12.8 0.0 1.5 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily Ephrin_rec_like PF07699.11 001099592.1_32325001_1 - 0.063 12.9 8.1 0.16 11.6 8.1 1.7 1 0 0 1 1 1 0 Putative ephrin-receptor like 7tm_3 PF00003.20 001099593.1_32326001_1 - 6.7e-65 219.0 26.4 1.3e-64 218.1 26.4 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099593.1_32326001_1 - 1.2e-54 185.6 0.0 1.6e-54 185.2 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099593.1_32326001_1 - 9.9e-20 70.1 11.4 2.5e-19 68.9 11.4 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001099593.1_32326001_1 - 0.00023 20.9 0.0 0.00036 20.2 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein Ephrin_rec_like PF07699.11 001099593.1_32326001_1 - 6.2 6.5 9.6 2.7 7.7 5.7 2.3 2 0 0 2 2 2 0 Putative ephrin-receptor like 7tm_3 PF00003.20 001099595.1_32326001_1 - 7.1e-65 218.9 28.1 7.1e-65 218.9 28.1 1.6 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099595.1_32326001_1 - 4.2e-52 177.3 0.0 5.8e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099595.1_32326001_1 - 5.4e-19 67.8 9.5 1.3e-18 66.5 9.5 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR ANF_receptor PF01094.26 001099596.1_32325001_1 - 7.8e-57 192.8 0.0 9.7e-57 192.5 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 001099596.1_32325001_1 - 6.1e-43 147.1 17.0 9.1e-43 146.6 17.0 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 001099596.1_32325001_1 - 4.2e-13 48.9 15.2 8.7e-13 47.9 15.2 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001099596.1_32325001_1 - 1.2e-05 25.1 0.0 1.8e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein DUF4131 PF13567.4 001099596.1_32325001_1 - 0.0094 15.4 1.2 0.0094 15.4 1.2 3.0 2 1 1 3 3 3 1 Domain of unknown function (DUF4131) TNFR_c6 PF00020.16 001099596.1_32325001_1 - 0.017 15.4 5.5 0.017 15.4 5.5 2.0 1 1 1 2 2 2 0 TNFR/NGFR cysteine-rich region CoA_binding_2 PF13380.4 001099596.1_32325001_1 - 0.095 13.1 0.1 0.18 12.2 0.1 1.4 1 0 0 1 1 1 0 CoA binding domain NMN_transporter PF04973.10 001099596.1_32325001_1 - 0.63 9.8 4.3 1.5 8.6 4.3 1.6 1 0 0 1 1 1 0 Nicotinamide mononucleotide transporter Homeobox PF00046.27 001106796.1_45722001_1 - 3.5e-18 65.0 6.7 5.1e-18 64.5 6.7 1.2 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001106796.1_45722001_1 - 0.01 15.6 1.8 0.026 14.3 1.8 1.7 1 0 0 1 1 1 0 Homeobox KN domain Homez PF11569.6 001106796.1_45722001_1 - 0.08 12.3 2.7 0.094 12.1 0.2 2.1 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez LRR_8 PF13855.4 001107577.1_45723001_1 - 1.6e-17 62.9 2.9 2.5e-08 33.4 0.5 3.6 1 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 001107577.1_45723001_1 - 1.2e-16 60.3 0.3 0.00015 21.9 0.0 4.6 3 1 0 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001107577.1_45723001_1 - 6e-06 25.7 0.0 0.091 12.1 0.1 2.4 1 1 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.31 001107577.1_45723001_1 - 0.0021 18.1 13.3 22 5.9 0.0 7.3 7 1 0 7 7 7 2 Leucine Rich Repeat RsmF_methylt_CI PF17126.3 001107577.1_45723001_1 - 0.017 15.0 4.0 21 5.1 0.0 4.7 5 1 0 5 5 5 0 RsmF rRNA methyltransferase first C-terminal domain 7tm_3 PF00003.20 001099560.1_32326001_1 - 1.2e-61 208.4 25.4 1.2e-61 208.4 25.4 2.1 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099560.1_32326001_1 - 2.4e-52 178.1 0.0 3.2e-52 177.7 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099560.1_32326001_1 - 5.2e-18 64.6 12.4 1.2e-17 63.5 12.4 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.11 001099560.1_32326001_1 - 1.2 8.8 9.4 3.2 7.5 9.4 1.7 1 0 0 1 1 1 0 Putative ephrin-receptor like 7tm_3 PF00003.20 001099562.1_32326001_1 - 1.7e-62 211.2 26.3 1.7e-62 211.2 26.3 2.1 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099562.1_32326001_1 - 1.2e-54 185.6 0.0 1.9e-54 184.9 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099562.1_32326001_1 - 1.5e-17 63.2 14.0 3.3e-17 62.1 14.0 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR ANF_receptor PF01094.26 001099569.1_32325001_1 - 3.3e-56 190.8 0.0 4.4e-56 190.4 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 001099569.1_32325001_1 - 4.7e-56 190.1 22.8 8e-56 189.3 22.8 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 001099569.1_32325001_1 - 6.7e-20 70.7 12.9 1.4e-19 69.7 12.9 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001099569.1_32325001_1 - 1.9e-05 24.4 0.0 3.6e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein Ephrin_rec_like PF07699.11 001099569.1_32325001_1 - 0.015 15.0 5.1 0.015 15.0 5.1 2.3 1 1 1 2 2 2 0 Putative ephrin-receptor like 7tm_3 PF00003.20 001099578.1_32325001_1 - 2.6e-62 210.5 25.7 5.5e-62 209.5 25.7 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099578.1_32325001_1 - 1.8e-60 204.8 0.0 2.3e-60 204.4 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099578.1_32325001_1 - 1.6e-18 66.3 11.9 1.6e-18 66.3 11.9 2.1 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001099578.1_32325001_1 - 0.0049 16.5 0.0 0.0073 15.9 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein Ephrin_rec_like PF07699.11 001099578.1_32325001_1 - 0.018 14.7 5.9 0.063 12.9 5.9 1.9 1 0 0 1 1 1 0 Putative ephrin-receptor like 7tm_3 PF00003.20 001099527.1_32326001_1 - 6.3e-63 212.6 21.2 1e-62 211.8 21.2 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099527.1_32326001_1 - 3.8e-48 164.3 0.0 5.2e-48 163.8 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099527.1_32326001_1 - 1e-20 73.3 14.8 2.5e-20 72.1 14.8 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR 7tm_3 PF00003.20 001099531.1_32326001_1 - 3.9e-59 200.1 25.9 3.9e-59 200.1 25.9 2.9 2 1 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099531.1_32326001_1 - 1e-50 172.7 0.0 1.3e-50 172.3 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099531.1_32326001_1 - 2.1e-16 59.5 16.0 5.5e-16 58.2 16.0 1.8 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR DUF2157 PF09925.7 001099531.1_32326001_1 - 5.1 6.8 12.3 4 7.1 3.5 2.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) 7tm_3 PF00003.20 001099532.1_32326001_1 - 1.5e-61 208.0 24.9 2.8e-61 207.1 24.9 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099532.1_32326001_1 - 3.1e-54 184.3 0.0 4e-54 183.9 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099532.1_32326001_1 - 9e-18 63.9 16.2 2.1e-17 62.7 16.2 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR 7tm_3 PF00003.20 001099534.1_32325001_1 - 5.2e-65 219.4 22.7 8.7e-65 218.6 22.7 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099534.1_32325001_1 - 4e-54 183.9 0.1 6e-54 183.3 0.1 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099534.1_32325001_1 - 1.5e-18 66.4 11.7 3e-18 65.4 11.7 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001099534.1_32325001_1 - 0.00019 21.2 0.0 0.00031 20.4 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein Globin PF00042.20 001168850.1_40421001_1 - 3e-31 108.1 0.0 1.2e-30 106.2 0.0 1.7 2 0 0 2 2 2 1 Globin DCX PF03607.15 001114621.1_45726001_1 - 2.4e-16 59.4 1.7 9.5e-06 25.5 0.0 4.3 4 1 1 5 5 5 3 Doublecortin PAXX PF15384.4 001114621.1_45726001_1 - 0.036 13.6 0.1 0.14 11.7 0.0 2.0 2 0 0 2 2 2 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 7tm_3 PF00003.20 001102419.1_32326001_1 - 3.3e-61 206.9 29.1 6e-61 206.1 28.7 1.7 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001102419.1_32326001_1 - 3.9e-50 170.8 0.0 5.2e-50 170.4 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001102419.1_32326001_1 - 2.4e-19 68.9 11.1 4.9e-19 67.9 11.1 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.11 001102419.1_32326001_1 - 2.7 7.7 8.0 6.7 6.4 8.0 1.7 1 0 0 1 1 1 0 Putative ephrin-receptor like Frag1 PF10277.7 001109538.1_45722001_1 - 5.2e-06 26.0 3.6 4.6e-05 22.9 0.2 2.4 3 0 0 3 3 3 2 Frag1/DRAM/Sfk1 family Frag1 PF10277.7 001109538.1_45722001_2 - 1.7e-29 102.8 5.6 2.4e-29 102.3 5.6 1.2 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family 7tm_3 PF00003.20 001102422.1_32326001_1 - 1.8e-62 211.0 29.1 1.8e-62 211.0 29.1 1.8 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001102422.1_32326001_1 - 1.7e-41 142.4 0.0 2.7e-41 141.7 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001102422.1_32326001_1 - 2.7e-18 65.5 13.3 6.9e-18 64.2 13.3 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR SP2 PF03014.12 001102422.1_32326001_1 - 0.19 9.6 0.1 0.28 9.0 0.1 1.1 1 0 0 1 1 1 0 Structural protein 2 rve_2 PF13333.4 001102422.1_32326001_1 - 0.23 11.5 1.2 0.76 9.9 1.2 1.9 1 0 0 1 1 1 0 Integrase core domain 7tm_1 PF00001.19 001127627.1_37623001_1 - 5.8e-45 153.5 13.5 7.4e-45 153.1 13.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Rhodopsin_N PF10413.7 001127627.1_37623001_1 - 7.6e-26 89.5 2.8 7.6e-26 89.5 2.8 2.2 2 0 0 2 2 2 1 Amino terminal of the G-protein receptor rhodopsin 7TM_GPCR_Srw PF10324.7 001127627.1_37623001_1 - 1.4e-08 34.3 19.9 6.1e-08 32.2 19.9 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.7 001127627.1_37623001_1 - 1.5e-07 31.0 21.8 2.9e-07 30.0 21.5 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 001127627.1_37623001_1 - 5.4e-07 29.1 19.8 7.4e-07 28.7 19.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TAS2R PF05296.11 001127627.1_37623001_1 - 0.0023 17.0 3.4 0.0023 17.0 3.4 2.1 2 0 0 2 2 2 1 Taste receptor protein (TAS2R) 7tm_4 PF13853.4 001127627.1_37623001_1 - 0.02 14.5 16.7 0.093 12.3 16.7 1.8 1 1 0 1 1 1 0 Olfactory receptor DUF4407 PF14362.4 001127627.1_37623001_1 - 0.55 9.4 3.0 0.48 9.6 0.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF4079 PF13301.4 001127627.1_37623001_1 - 3.6 7.6 7.1 7.7 6.5 3.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) 7tm_4 PF13853.4 001168865.1_40422001_1 - 7.5e-104 347.2 20.4 8.5e-104 347.0 20.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168865.1_40422001_1 - 1.8e-17 63.3 20.7 3.7e-17 62.3 20.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168865.1_40422001_1 - 4.4e-08 32.7 10.8 4.4e-08 32.7 10.8 1.7 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.7 001168865.1_40422001_1 - 1.3 8.3 16.2 0.098 12.0 9.9 2.2 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_4 PF13853.4 001168866.1_40422001_1 - 2.3e-107 358.8 19.6 2.7e-107 358.5 19.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168866.1_40422001_1 - 3.8e-19 68.8 18.2 7.8e-19 67.8 18.2 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168866.1_40422001_1 - 5e-11 42.3 10.7 5e-11 42.3 10.7 2.0 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx DNA_ligase_A_N PF04675.12 001168866.1_40422001_1 - 0.18 12.0 0.0 0.26 11.5 0.0 1.2 1 0 0 1 1 1 0 DNA ligase N terminus Keratin_B2_2 PF13885.4 001109555.1_45723001_1 - 4.8e-29 99.9 346.7 1.8e-06 27.7 49.1 7.8 1 1 6 7 7 7 7 Keratin, high sulfur B2 protein Keratin_B2 PF01500.15 001109555.1_45723001_1 - 0.42 10.5 260.4 2.3 8.1 127.3 6.1 1 1 3 4 4 4 0 Keratin, high sulfur B2 protein 7tm_4 PF13853.4 001168869.1_40422001_1 - 2.9e-70 237.1 13.9 3.2e-70 236.9 13.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168869.1_40422001_1 - 6.7e-05 22.1 17.3 0.00098 18.3 17.3 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ig_2 PF13895.4 001168880.1_40424001_1 - 4.5e-33 113.3 0.8 6.4e-14 51.9 0.1 4.3 4 0 0 4 4 4 4 Immunoglobulin domain Ig_3 PF13927.4 001168880.1_40424001_1 - 3.6e-26 91.4 0.9 1.5e-05 25.4 0.0 4.7 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 001168880.1_40424001_1 - 2.7e-19 69.0 0.1 0.00012 22.1 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain DUF2304 PF10066.7 001168880.1_40424001_1 - 0.023 14.8 0.1 0.037 14.1 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) DUF4692 PF15763.3 001168880.1_40424001_1 - 0.086 13.2 0.0 0.23 11.8 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4692) Rifin_STEVOR PF02009.14 001168880.1_40424001_1 - 0.25 11.1 0.2 0.39 10.4 0.2 1.2 1 0 0 1 1 1 0 Rifin/stevor family SIT PF15330.4 001168880.1_40424001_1 - 3.2 8.1 6.7 12 6.2 1.4 2.7 1 1 1 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Fibrillarin PF01269.15 001108824.1_45724001_2 - 3e-106 353.5 0.0 3.7e-106 353.2 0.0 1.1 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.8 001108824.1_45724001_2 - 0.005 16.4 0.0 0.0076 15.8 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.17 001108824.1_45724001_2 - 0.14 11.8 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ig_2 PF13895.4 001128451.1_49824001_3 - 1.6e-28 98.8 0.4 2.3e-07 30.9 0.0 4.2 4 0 0 4 4 4 4 Immunoglobulin domain Ig_3 PF13927.4 001128451.1_49824001_3 - 5.5e-22 78.0 1.1 2.6e-05 24.6 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 001128451.1_49824001_3 - 9.8e-22 76.8 0.1 2.7e-05 24.1 0.0 4.2 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.15 001128451.1_49824001_3 - 2.5e-05 24.3 5.3 9.5 6.3 0.2 5.9 4 3 1 5 5 5 2 Immunoglobulin V-set domain I-set PF07679.14 001128451.1_49824001_3 - 0.063 13.2 0.0 4 7.5 0.0 3.3 3 1 0 3 3 3 0 Immunoglobulin I-set domain Ig_4 PF16680.3 001128451.1_49824001_3 - 0.53 10.6 7.6 39 4.6 0.0 4.7 4 1 0 4 4 4 0 T-cell surface glycoprotein CD3 delta chain UPAR_LY6 PF00021.19 001109623.1_45722001_2 - 0.00067 20.2 8.3 0.00098 19.6 8.3 1.3 1 0 0 1 1 1 1 u-PAR/Ly-6 domain CARD PF00619.19 001106413.1_45729001_3 - 8e-18 64.1 0.5 1.4e-17 63.3 0.5 1.4 1 0 0 1 1 1 1 Caspase recruitment domain Cadherin PF00028.15 001109390.1_45727001_3 - 1.4e-79 262.5 0.0 1.4e-16 60.6 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001109390.1_45727001_3 - 1.8e-37 126.8 0.8 4.4e-32 109.6 0.0 4.3 5 0 0 5 5 5 2 Cadherin-like Cadherin_C_2 PF16492.3 001109390.1_45727001_3 - 6.4e-27 94.0 0.0 1.9e-26 92.5 0.0 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001109390.1_45727001_3 - 8e-09 35.4 3.0 0.00082 19.2 0.1 4.6 5 0 0 5 5 5 2 Cadherin-like Cache_3-Cache_2 PF17201.2 001109390.1_45727001_3 - 0.14 11.3 0.1 0.21 10.7 0.1 1.2 1 0 0 1 1 1 0 Cache 3/Cache 2 fusion domain 7tm_1 PF00001.19 001111024.1_32322001_1 - 1.7e-31 109.4 38.7 1.1e-30 106.7 38.7 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001111024.1_32322001_1 - 1.2e-10 41.5 24.4 9.3e-10 38.6 16.4 2.7 1 1 2 3 3 3 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001111024.1_32322001_1 - 1.9e-10 40.4 34.1 3.3e-10 39.6 34.1 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001111024.1_32322001_1 - 0.5 9.5 38.7 0.011 14.9 19.4 2.5 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_3 PF00003.20 001102466.1_32325001_1 - 3.7e-66 223.1 21.4 6.3e-66 222.4 21.4 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001102466.1_32325001_1 - 2.5e-48 164.9 0.0 3.7e-48 164.3 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001102466.1_32325001_1 - 9.1e-17 60.7 12.0 1.7e-16 59.8 12.0 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR DUF5080 PF16883.3 001102466.1_32325001_1 - 0.023 14.7 2.7 0.071 13.1 2.7 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5080) Ephrin_rec_like PF07699.11 001102466.1_32325001_1 - 0.05 13.2 8.1 0.12 12.0 8.1 1.6 1 0 0 1 1 1 0 Putative ephrin-receptor like DUF2157 PF09925.7 001102466.1_32325001_1 - 2.1 8.0 9.1 5.9 6.5 0.8 2.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) 7tm_4 PF13853.4 001168837.1_40422001_1 - 2.8e-107 358.5 24.7 3.2e-107 358.3 24.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168837.1_40422001_1 - 2.9e-16 59.4 24.3 9.2e-16 57.7 24.3 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168837.1_40422001_1 - 0.00029 20.2 20.2 0.00058 19.2 20.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Mit_KHE1 PF10173.7 001168837.1_40422001_1 - 0.057 13.4 1.4 0.088 12.8 1.4 1.2 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related 7tm_4 PF13853.4 001168838.1_40422001_1 - 5.8e-126 419.8 26.9 6.8e-126 419.5 26.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168838.1_40422001_1 - 3.9e-14 52.4 23.2 1e-13 51.0 23.2 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168838.1_40422001_1 - 0.00042 19.7 21.6 0.00058 19.2 21.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4417 PF14386.4 001168844.1_40422001_1 - 0.0068 15.9 0.1 0.012 15.1 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4417) ANF_receptor PF01094.26 001102451.1_32325001_1 - 3e-86 289.6 0.0 3.8e-86 289.2 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 001102451.1_32325001_1 - 1.9e-55 188.1 23.8 3.1e-55 187.4 23.8 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 001102451.1_32325001_1 - 2.3e-14 52.9 4.4 2.3e-14 52.9 4.4 2.0 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001102451.1_32325001_1 - 0.00033 20.3 0.1 0.00047 19.8 0.1 1.2 1 0 0 1 1 1 1 Periplasmic binding protein YesK PF14150.4 001102451.1_32325001_1 - 7.3 6.7 11.0 0.23 11.5 1.9 2.9 2 1 1 3 3 3 0 YesK-like protein 7tm_3 PF00003.20 001102429.1_32325001_1 - 1.2e-61 208.4 29.4 4.6e-61 206.5 28.7 2.3 3 0 0 3 3 3 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001102429.1_32325001_1 - 5.4e-47 160.5 0.0 7.3e-47 160.0 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001102429.1_32325001_1 - 1.2e-16 60.2 11.7 2.5e-16 59.2 11.7 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001102429.1_32325001_1 - 0.024 14.2 0.0 0.035 13.7 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein DUF1600 PF07667.9 001102429.1_32325001_1 - 0.43 10.7 5.8 0.068 13.2 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1600) 7tm_3 PF00003.20 001102447.1_32325001_1 - 5.6e-67 225.8 21.0 1.2e-66 224.8 21.0 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001102447.1_32325001_1 - 1.3e-51 175.7 0.1 1.8e-51 175.2 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001102447.1_32325001_1 - 2.8e-14 52.7 10.8 5.2e-14 51.8 10.8 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR FYVE PF01363.19 001128477.1_49829001_1 - 2.3e-16 59.5 18.4 7.5e-16 57.9 18.4 2.0 1 0 0 1 1 1 1 FYVE zinc finger RUN PF02759.17 001128477.1_49829001_1 - 2.8e-09 36.9 0.1 2.8e-09 36.9 0.1 4.2 4 1 0 4 4 4 2 RUN domain tRNA-synt_1d PF00750.17 001128477.1_49829001_1 - 4 6.1 8.6 1.2 7.9 2.2 2.9 3 0 0 3 3 3 0 tRNA synthetases class I (R) Branch PF02485.19 001105213.1_37623001_1 - 2.8e-60 203.7 0.1 3.6e-60 203.4 0.1 1.1 1 0 0 1 1 1 1 Core-2/I-Branching enzyme 7tm_4 PF13853.4 001168839.1_40422001_1 - 2.6e-107 358.6 22.4 3.4e-107 358.2 22.4 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168839.1_40422001_1 - 8.2e-13 48.1 26.5 1.2e-11 44.3 26.5 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168839.1_40422001_1 - 2.3e-09 36.9 10.5 2.3e-09 36.9 10.5 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx V1R PF03402.12 001167264.1_37922001_1 - 1.5e-96 323.0 25.9 1.8e-96 322.7 25.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167264.1_37922001_1 - 2.1e-06 26.9 26.4 2.7e-06 26.6 26.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) bPH_3 PF14470.4 001167264.1_37922001_1 - 0.066 13.5 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial PH domain V1R PF03402.12 001167514.1_32322001_1 - 5.1e-34 118.0 13.9 6.4e-34 117.6 13.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167514.1_32322001_1 - 5.1e-10 38.8 19.3 5.9e-10 38.6 19.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) LRR19-TM PF15176.4 001167514.1_32322001_1 - 0.49 10.3 4.5 6.6 6.6 0.2 2.8 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain V1R PF03402.12 001167265.1_37922001_1 - 3.1e-33 115.4 17.1 4.2e-33 115.0 17.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167265.1_37922001_1 - 4.4e-11 42.3 19.2 4.9e-11 42.2 19.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167265.1_37922001_1 - 0.0038 16.4 15.3 0.0068 15.5 15.3 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167515.1_32322001_1 - 6.1e-37 127.5 10.5 7.5e-37 127.3 10.5 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167515.1_32322001_1 - 4.7e-13 48.8 15.3 5.6e-13 48.5 15.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) LRR19-TM PF15176.4 001167515.1_32322001_1 - 1.1 9.1 4.5 7.3 6.5 0.3 3.0 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain zf-DHHC PF01529.18 001167515.1_32322001_1 - 5.6 6.9 13.4 4 7.4 1.4 3.3 2 1 0 2 2 2 0 DHHC palmitoyltransferase V1R PF03402.12 001167266.1_37922001_1 - 4.2e-36 124.8 10.0 6.2e-36 124.2 10.0 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167266.1_37922001_1 - 7.3e-11 41.6 12.7 8.7e-11 41.3 12.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167266.1_37922001_1 - 0.001 18.3 13.5 0.0034 16.5 13.4 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167516.1_32322001_1 - 5.1e-36 124.5 11.2 6.3e-36 124.2 11.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167516.1_32322001_1 - 4.5e-11 42.3 16.2 5.4e-11 42.0 16.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) LRR19-TM PF15176.4 001167516.1_32322001_1 - 0.64 9.9 3.6 7.3 6.5 0.3 3.0 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain zf-DHHC PF01529.18 001167516.1_32322001_1 - 6.7 6.7 14.1 4 7.4 1.4 3.4 2 1 0 2 2 2 0 DHHC palmitoyltransferase V1R PF03402.12 001167267.1_37922001_1 - 1.5e-35 123.0 17.5 1.8e-35 122.7 17.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167267.1_37922001_1 - 1.4e-13 50.5 20.3 1.8e-13 50.2 20.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167267.1_37922001_1 - 4.1e-07 29.4 15.5 5.3e-07 29.0 15.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1003 PF06210.9 001167267.1_37922001_1 - 0.14 12.2 2.5 0.17 11.9 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) V1R PF03402.12 001167517.1_32322001_1 - 1.5e-28 100.0 20.9 2.1e-28 99.6 20.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167517.1_32322001_1 - 8.2e-18 64.4 31.3 9.4e-18 64.2 31.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167517.1_32322001_1 - 4.4e-05 22.7 26.3 4.7e-05 22.6 25.6 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167268.1_37922001_1 - 8.2e-28 97.6 15.1 1e-27 97.3 15.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167268.1_37922001_1 - 3e-07 29.7 15.2 3.7e-07 29.4 15.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Nucleo_LEF-12 PF06256.9 001167268.1_37922001_1 - 0.14 11.8 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus LEF-12 protein V1R PF03402.12 001167518.1_32322001_1 - 2.3e-28 99.4 22.0 3.1e-28 99.0 22.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167518.1_32322001_1 - 3.9e-17 62.2 32.0 4.4e-17 62.0 32.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167518.1_32322001_1 - 3.6e-05 23.0 24.6 5.4e-05 22.4 24.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167519.1_32322001_1 - 1.9e-32 112.8 18.7 2.5e-32 112.4 18.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167519.1_32322001_1 - 1.1e-15 57.4 28.0 1.4e-15 57.1 28.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167519.1_32322001_1 - 3.7e-05 23.0 22.8 4.8e-05 22.6 22.6 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167520.1_32322001_1 - 2.4e-33 115.7 18.2 3.3e-33 115.3 18.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167520.1_32322001_1 - 1.4e-16 60.3 28.3 1.7e-16 60.1 28.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167520.1_32322001_1 - 4.1e-05 22.8 20.9 5.6e-05 22.4 20.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ndc1_Nup PF09531.8 001167520.1_32322001_1 - 1 7.8 9.6 1.6 7.1 9.6 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup V1R PF03402.12 001167272.1_37922001_1 - 1.7e-65 221.2 29.5 2e-65 220.9 29.5 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167272.1_37922001_1 - 1.2e-06 27.7 34.3 1.5e-06 27.4 34.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167522.1_32322001_1 - 1.2e-31 110.1 20.7 1.6e-31 109.8 20.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167522.1_32322001_1 - 2.9e-15 56.0 29.2 3.6e-15 55.7 29.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167522.1_32322001_1 - 5e-05 22.5 22.1 6.6e-05 22.1 22.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167273.1_37923001_1 - 3e-29 102.3 12.9 4.3e-29 101.8 12.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167273.1_37923001_1 - 0.003 16.6 17.2 0.0049 15.9 17.2 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167275.1_37922001_1 - 7.9e-36 123.9 16.4 9.3e-36 123.7 16.4 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167275.1_37922001_1 - 1.1e-05 24.6 20.0 2.4e-05 23.5 20.0 1.4 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167275.1_37922001_1 - 0.00016 20.9 16.4 0.00026 20.2 16.4 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GP4 PF03010.12 001167275.1_37922001_1 - 0.0042 16.9 0.2 0.012 15.4 0.1 1.8 2 0 0 2 2 2 1 GP4 V1R PF03402.12 001167276.1_37922001_1 - 1.8e-53 181.7 29.9 2.1e-53 181.5 29.9 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167276.1_37922001_1 - 0.00066 18.7 33.9 0.00082 18.4 33.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167277.1_37922001_1 - 3.5e-70 236.5 29.7 4.2e-70 236.3 29.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167277.1_37922001_1 - 5e-08 32.3 33.9 6.4e-08 31.9 33.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167277.1_37922001_1 - 0.0026 16.9 28.8 0.005 16.0 28.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167278.1_37922001_1 - 2e-35 122.6 15.3 3.3e-35 121.9 15.3 1.3 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167278.1_37922001_1 - 4.4e-06 26.0 12.2 5.8e-06 25.6 11.8 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167278.1_37922001_1 - 0.00077 18.5 17.8 0.0013 17.8 17.8 1.4 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) Keratin_B2_2 PF13885.4 001161382.1_39522001_1 - 3.6e-44 148.3 363.9 6.7e-10 38.6 52.6 9.7 1 1 7 8 8 8 7 Keratin, high sulfur B2 protein Keratin_B2 PF01500.15 001161382.1_39522001_1 - 3.7e-17 62.7 265.4 2e-06 27.8 56.1 6.0 1 1 3 4 4 4 3 Keratin, high sulfur B2 protein V1R PF03402.12 001167279.1_37922001_1 - 1.8e-18 67.0 10.5 3.2e-15 56.3 2.2 2.1 1 1 1 2 2 2 2 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167279.1_37922001_1 - 1.5e-05 24.2 3.4 1.5e-05 24.2 3.4 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167281.1_37922001_1 - 2.5e-39 135.4 13.7 3.6e-39 134.8 13.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167281.1_37922001_1 - 9.3e-11 41.2 17.9 1.1e-10 41.0 17.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167281.1_37922001_1 - 2.2e-06 27.0 15.9 3e-06 26.5 15.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4714 PF15833.3 001167281.1_37922001_1 - 0.048 13.5 0.7 0.13 12.1 0.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4714) V1R PF03402.12 001167282.1_37922001_1 - 1.8e-28 99.8 16.0 2.4e-28 99.4 16.0 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167282.1_37922001_1 - 1e-06 28.1 11.3 2.2e-06 27.0 11.3 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167282.1_37922001_1 - 6.6e-06 25.3 14.9 8.6e-06 24.9 14.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) EXS PF03124.12 001167282.1_37922001_1 - 0.0062 15.7 5.0 0.01 15.0 5.0 1.3 1 0 0 1 1 1 1 EXS family V1R PF03402.12 001167285.1_37922001_1 - 6.3e-36 124.2 9.3 8.2e-36 123.8 9.3 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167285.1_37922001_1 - 3.9e-08 32.7 8.5 5.4e-08 32.3 8.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167285.1_37922001_1 - 1.5e-07 30.7 10.7 2.3e-07 30.1 10.7 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TIR_2 PF13676.4 001204346.1_37922001_1 - 1.8e-09 37.7 0.0 2.9e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 TIR domain TIR PF01582.18 001204346.1_37922001_1 - 0.009 15.7 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 TIR domain V1R PF03402.12 001166778.1_32322001_1 - 1.7e-32 113.0 10.9 2.2e-32 112.6 10.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166778.1_32322001_1 - 7.8e-08 31.6 19.5 9.5e-08 31.4 19.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166778.1_32322001_1 - 0.029 13.5 10.2 0.043 12.9 10.2 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF2306 PF10067.7 001166778.1_32322001_1 - 0.25 11.4 10.0 0.48 10.5 0.2 2.7 3 0 0 3 3 3 0 Predicted membrane protein (DUF2306) V1R PF03402.12 001167286.1_37922001_1 - 4.4e-27 95.2 17.5 5.7e-27 94.8 17.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167286.1_37922001_1 - 1.2e-08 34.3 25.2 1.5e-08 34.0 25.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167286.1_37922001_1 - 9.7e-07 28.1 17.5 1.2e-06 27.8 17.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FAM124 PF15067.4 001204114.1_37922001_1 - 0.17 11.4 0.1 0.22 11.0 0.1 1.1 1 0 0 1 1 1 0 FAM124 family eIF_4EBP PF05456.9 001204114.1_37922001_3 - 2.5e-31 107.9 1.0 3.2e-31 107.5 1.0 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) V1R PF03402.12 001167287.1_37922001_1 - 3.3e-31 108.7 11.8 5.1e-31 108.1 11.8 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167287.1_37922001_1 - 1.5e-07 30.7 13.2 1.9e-07 30.4 13.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167287.1_37922001_1 - 1.3e-06 27.8 10.6 1.8e-06 27.2 10.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166779.1_32322001_1 - 1.9e-33 116.1 16.8 2.3e-33 115.8 16.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166779.1_32322001_1 - 2.2e-09 36.7 22.9 2.6e-09 36.5 22.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167288.1_37922001_1 - 1.2e-37 129.9 13.4 1.4e-37 129.7 13.4 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167288.1_37922001_1 - 5.5e-05 22.4 14.3 0.00011 21.4 14.3 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167288.1_37922001_1 - 0.00023 20.3 17.7 0.00038 19.5 17.7 1.4 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) GP4 PF03010.12 001167288.1_37922001_1 - 0.0064 16.3 0.1 0.015 15.1 0.1 1.6 1 0 0 1 1 1 1 GP4 V1R PF03402.12 001166780.1_32322001_1 - 2.6e-27 96.0 23.6 3e-27 95.8 23.6 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166780.1_32322001_1 - 9.6e-20 70.7 33.1 1.1e-19 70.5 33.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166780.1_32322001_1 - 0.0074 15.4 23.1 0.01 15.0 23.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) RRM_1 PF00076.20 001171333.1_37926001_1 - 1.3e-30 104.8 0.9 1.1e-07 31.4 0.0 5.4 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) V1R PF03402.12 001167291.1_37922001_1 - 2.5e-39 135.4 13.3 2.9e-39 135.2 13.3 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167291.1_37922001_1 - 6.4e-05 22.2 14.5 0.00012 21.3 14.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167291.1_37922001_1 - 0.00036 19.6 16.9 0.00064 18.8 16.9 1.4 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) GP4 PF03010.12 001167291.1_37922001_1 - 0.0024 17.6 0.3 0.006 16.4 0.1 1.7 2 0 0 2 2 2 1 GP4 V1R PF03402.12 001166781.1_32322001_1 - 4e-27 95.4 20.8 4.7e-27 95.1 20.8 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166781.1_32322001_1 - 1.4e-18 67.0 29.7 1.6e-18 66.7 29.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166781.1_32322001_1 - 0.0077 15.4 20.2 0.011 14.9 20.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167293.1_37922001_1 - 4.1e-51 174.0 21.7 5e-51 173.7 21.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R V1R PF03402.12 001166782.1_32323001_1 - 4e-31 108.5 20.0 4.9e-31 108.2 20.0 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166782.1_32323001_1 - 4.7e-06 25.8 23.7 6.1e-06 25.4 23.7 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001166783.1_32322001_1 - 4.3e-34 118.2 16.8 5.7e-34 117.8 16.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166783.1_32322001_1 - 5.8e-11 41.9 20.1 8.2e-11 41.4 20.1 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167300.1_37922001_1 - 2.8e-65 220.4 26.9 3.4e-65 220.2 26.9 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167300.1_37922001_1 - 0.013 14.5 30.8 0.021 13.8 30.8 1.3 1 0 0 1 1 1 0 Taste receptor protein (TAS2R) V1R PF03402.12 001167301.1_37922001_1 - 9.4e-42 143.3 15.7 1.3e-41 142.9 15.7 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167301.1_37922001_1 - 3.3e-16 59.2 25.1 3.8e-16 58.9 25.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167301.1_37922001_1 - 3.6e-07 29.6 19.7 5.6e-07 28.9 19.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166784.1_32322001_1 - 3.4e-26 92.3 18.0 4.3e-26 92.0 18.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166784.1_32322001_1 - 2e-14 53.3 23.4 2.2e-14 53.2 23.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166784.1_32322001_1 - 1.1e-06 27.9 19.0 1.4e-06 27.6 19.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1365 PF07103.9 001166784.1_32322001_1 - 0.058 13.0 0.2 0.11 12.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1365) V1R PF03402.12 001167303.1_37922001_1 - 1.5e-34 119.7 13.6 2e-34 119.3 13.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167303.1_37922001_1 - 1.7e-12 46.9 18.1 2e-12 46.7 18.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167303.1_37922001_1 - 0.00043 19.5 14.1 0.00066 18.9 14.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2175 PF09943.7 001167303.1_37922001_1 - 0.064 13.4 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) DUF3989 PF13150.4 001167303.1_37922001_1 - 0.16 11.6 1.5 1.5 8.5 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3989) V1R PF03402.12 001166785.1_32322001_1 - 1.5e-26 93.5 18.6 2.3e-26 92.9 18.6 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166785.1_32322001_1 - 2.2e-11 43.3 25.6 2.8e-11 42.9 25.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TarH PF02203.13 001166785.1_32322001_1 - 0.07 12.9 0.5 0.15 11.9 0.1 1.7 2 0 0 2 2 2 0 Tar ligand binding domain homologue V1R PF03402.12 001167305.1_37922001_1 - 1.2e-36 126.6 13.4 1.4e-36 126.4 13.4 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167305.1_37922001_1 - 4.4e-06 25.9 16.3 6.3e-06 25.4 16.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167305.1_37922001_1 - 2.6e-05 23.4 16.7 4.3e-05 22.7 16.7 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GP4 PF03010.12 001167305.1_37922001_1 - 0.012 15.4 0.2 0.029 14.2 0.1 1.7 2 0 0 2 2 2 0 GP4 V1R PF03402.12 001166786.1_32322001_1 - 3.7e-30 105.3 19.5 5.1e-30 104.8 19.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166786.1_32322001_1 - 9.1e-14 51.1 28.9 1.1e-13 50.9 28.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167306.1_37922001_1 - 6.1e-34 117.7 9.1 8.3e-34 117.3 9.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167306.1_37922001_1 - 3.2e-07 29.7 9.7 4.3e-07 29.3 9.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167306.1_37922001_1 - 9e-07 28.2 10.1 1.4e-06 27.5 10.1 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) RSN1_TM PF13967.4 001167306.1_37922001_1 - 0.018 14.7 2.4 2.1 8.0 0.3 2.5 1 1 1 2 2 2 0 Late exocytosis, associated with Golgi transport Cation_ATPase_C PF00689.19 001167306.1_37922001_1 - 0.14 11.8 5.1 0.28 10.8 5.1 1.5 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus V1R PF03402.12 001167307.1_37922001_1 - 6.8e-33 114.3 18.7 9.2e-33 113.8 18.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167307.1_37922001_1 - 1e-05 24.7 20.4 1.2e-05 24.4 20.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167307.1_37922001_1 - 8.3e-05 21.8 16.1 0.00012 21.3 16.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166787.1_32322001_1 - 1.4e-28 100.1 21.7 2.3e-28 99.4 21.7 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166787.1_32322001_1 - 1.3e-12 47.3 28.1 1.5e-12 47.2 28.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167309.1_37922001_1 - 3.9e-36 124.9 14.5 4.8e-36 124.6 14.5 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167309.1_37922001_1 - 2.5e-10 39.8 21.5 3.2e-10 39.5 21.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167309.1_37922001_1 - 6.4e-05 22.2 14.8 9.1e-05 21.7 14.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2569 PF10754.7 001167309.1_37922001_1 - 0.0013 19.0 4.6 0.0013 19.0 4.6 2.4 1 1 2 3 3 3 1 Protein of unknown function (DUF2569) zf-DHHC PF01529.18 001167309.1_37922001_1 - 0.65 10.0 14.7 0.036 14.0 2.8 2.6 2 1 0 2 2 2 0 DHHC palmitoyltransferase V1R PF03402.12 001166788.1_32322001_1 - 3.6e-22 79.1 23.1 4.6e-22 78.8 23.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166788.1_32322001_1 - 8.8e-07 28.2 31.7 1e-06 27.9 31.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Ferlin_C PF16165.3 001166788.1_32322001_1 - 0.0052 16.6 5.6 0.19 11.6 0.2 2.5 2 0 0 2 2 2 2 Ferlin C-terminus V1R PF03402.12 001167310.1_37922001_1 - 3e-35 122.0 10.8 3.7e-35 121.7 10.8 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167310.1_37922001_1 - 4.8e-08 32.3 14.5 5.9e-08 32.0 14.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167310.1_37922001_1 - 1.2e-07 31.1 14.3 1.7e-07 30.6 14.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167311.1_37922001_1 - 8.1e-35 120.6 11.3 1.1e-34 120.2 11.3 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167311.1_37922001_1 - 4.5e-09 35.7 11.8 5.5e-09 35.4 11.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167311.1_37922001_1 - 1.6e-06 27.4 8.7 2.3e-06 26.9 8.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Cation_ATPase_C PF00689.19 001167311.1_37922001_1 - 0.23 11.0 5.4 0.56 9.8 5.4 1.5 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus V1R PF03402.12 001166789.1_32322001_1 - 2.3e-28 99.4 19.8 3.5e-28 98.8 19.8 1.3 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166789.1_32322001_1 - 2.6e-12 46.3 27.1 2.9e-12 46.2 27.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167313.1_37922001_1 - 4.5e-38 131.3 13.5 6.2e-38 130.8 13.5 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167313.1_37922001_1 - 4.7e-10 38.9 13.8 6.2e-10 38.5 13.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167313.1_37922001_1 - 8.8e-05 21.7 14.3 0.00012 21.3 14.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166790.1_32322001_1 - 1.2e-34 120.0 19.7 1.6e-34 119.6 19.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166790.1_32322001_1 - 1.5e-08 34.0 28.0 1.5e-08 34.0 28.0 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167315.1_37922001_1 - 6.1e-37 127.5 16.4 7.2e-37 127.3 16.4 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167315.1_37922001_1 - 2.7e-05 23.4 15.8 4.4e-05 22.7 15.8 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167315.1_37922001_1 - 6e-05 22.2 17.9 8.8e-05 21.6 17.9 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) GP4 PF03010.12 001167315.1_37922001_1 - 0.0052 16.6 0.1 0.011 15.6 0.1 1.6 1 0 0 1 1 1 1 GP4 V1R PF03402.12 001166791.1_32322001_1 - 1.6e-26 93.4 19.3 2.9e-26 92.5 19.3 1.4 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166791.1_32322001_1 - 4.5e-09 35.7 26.6 5.3e-09 35.5 26.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TspO_MBR PF03073.13 001166791.1_32322001_1 - 0.006 16.5 2.9 0.006 16.5 2.9 2.1 1 1 1 2 2 2 1 TspO/MBR family Sod_Fe_C PF02777.16 001166791.1_32322001_1 - 0.032 14.3 0.0 1 9.4 0.0 2.2 2 0 0 2 2 2 0 Iron/manganese superoxide dismutases, C-terminal domain Ferlin_C PF16165.3 001166791.1_32322001_1 - 3.3 7.5 8.3 12 5.7 0.2 2.5 2 0 0 2 2 2 0 Ferlin C-terminus V1R PF03402.12 001167316.1_37922001_1 - 2.8e-34 118.8 15.3 3.7e-34 118.4 15.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167316.1_37922001_1 - 2.4e-06 26.9 11.1 3.4e-06 26.4 11.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167316.1_37922001_1 - 0.0047 15.9 15.2 0.0079 15.2 15.2 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) FATC PF02260.18 001167316.1_37922001_2 - 0.053 13.2 0.1 0.053 13.2 0.1 2.1 3 0 0 3 3 3 0 FATC domain V1R PF03402.12 001166792.1_32322001_1 - 1.7e-35 122.8 14.4 2.1e-35 122.5 14.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166792.1_32322001_1 - 6e-10 38.6 20.3 7.2e-10 38.3 20.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167318.1_37922001_1 - 4e-36 124.9 10.8 4e-36 124.9 10.8 1.4 2 0 0 2 2 2 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167318.1_37922001_1 - 1.2e-12 47.5 14.5 1.4e-12 47.2 14.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167318.1_37922001_1 - 2.9e-07 29.9 10.2 3.4e-07 29.6 9.4 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF5012 PF16404.3 001167318.1_37922001_1 - 0.004 17.1 0.0 0.11 12.5 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF5012) DUF4064 PF13273.4 001167318.1_37922001_1 - 3.1 8.0 8.0 2.3 8.5 1.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) TarH PF02203.13 001167318.1_37922001_1 - 3.5 7.4 5.4 17 5.2 0.3 2.5 2 1 0 2 2 2 0 Tar ligand binding domain homologue V1R PF03402.12 001166793.1_32322001_1 - 4.5e-29 101.8 12.0 8e-29 100.9 12.0 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001166793.1_32322001_1 - 3.3e-07 29.7 13.9 4e-07 29.4 13.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001166793.1_32322001_1 - 1.8e-06 27.2 16.9 2.3e-06 26.8 16.9 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Ctr PF04145.13 001166793.1_32322001_1 - 0.35 11.4 6.7 0.64 10.5 3.2 2.5 2 1 0 2 2 2 0 Ctr copper transporter family V1R PF03402.12 001167319.1_37922001_1 - 2.4e-29 102.6 20.2 3.2e-29 102.2 20.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167319.1_37922001_1 - 1.4e-06 27.7 16.6 2.1e-06 27.1 16.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167319.1_37922001_1 - 8.4e-06 25.0 19.3 1.1e-05 24.7 19.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167320.1_37922001_1 - 7.8e-66 222.3 26.6 9.5e-66 222.0 26.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167320.1_37922001_1 - 4.1e-05 22.7 32.9 4.9e-05 22.5 32.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001166794.1_32322001_1 - 7.4e-35 120.7 10.8 1e-34 120.2 10.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166794.1_32322001_1 - 5.3e-15 55.2 16.6 6.5e-15 54.9 16.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166794.1_32322001_1 - 0.00077 18.6 12.9 0.001 18.2 12.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4917 PF16263.3 001166794.1_32322001_1 - 0.014 14.6 0.1 0.02 14.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4917) ECF_trnsprt PF12822.5 001166794.1_32322001_1 - 3.7 7.4 9.5 1.1e+03 -0.6 9.5 2.8 1 1 0 1 1 1 0 ECF transporter, substrate-specific component V1R PF03402.12 001166795.1_32322001_1 - 7.2e-35 120.8 8.8 1e-34 120.3 8.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166795.1_32322001_1 - 1.4e-15 57.1 16.9 1.7e-15 56.8 16.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166795.1_32322001_1 - 0.0039 16.3 14.1 0.0055 15.8 14.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167323.1_37922001_1 - 2.6e-23 82.9 14.0 3.1e-23 82.6 14.0 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167323.1_37922001_1 - 2e-09 36.9 18.5 2.4e-09 36.6 18.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Ninjurin PF04923.10 001167323.1_37922001_1 - 0.042 13.6 0.6 0.11 12.3 0.3 1.8 1 1 1 2 2 2 0 Ninjurin 7tm_1 PF00001.19 001173398.1_09923001_1 - 3.3e-31 108.4 38.3 2.1e-30 105.8 38.3 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001173398.1_09923001_1 - 8.5e-11 42.0 24.5 7.5e-08 32.3 24.5 2.6 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001173398.1_09923001_1 - 1.8e-10 40.5 33.3 3e-10 39.8 33.3 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001173398.1_09923001_1 - 1.9 7.6 37.7 8e+03 -4.3 37.7 2.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx V1R PF03402.12 001166796.1_32322001_1 - 1.5e-35 122.9 9.0 2.2e-35 122.5 9.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166796.1_32322001_1 - 9.9e-17 60.9 15.5 1.2e-16 60.6 15.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166796.1_32322001_1 - 0.0002 20.6 13.4 0.00027 20.1 13.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Cytochrom_B_N_2 PF13631.4 001166796.1_32322001_1 - 6.6 6.6 9.7 0.27 11.1 1.4 2.5 2 1 1 3 3 3 0 Cytochrome b(N-terminal)/b6/petB V1R PF03402.12 001167325.1_37923001_1 - 9.1e-30 104.0 10.1 1.3e-29 103.5 10.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167325.1_37923001_1 - 0.0032 16.5 13.8 0.006 15.6 13.8 1.4 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167325.1_37923001_1 - 0.0048 16.0 12.0 0.0043 16.2 11.0 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Trypsin PF00089.24 001159809.1_43522001_1 - 6.9e-66 222.1 0.0 7.8e-66 221.9 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001159809.1_43522001_1 - 1.8e-05 25.5 0.1 4.1e-05 24.4 0.1 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001159809.1_43522001_1 - 0.00042 20.6 0.6 0.0022 18.3 0.6 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) V1R PF03402.12 001166797.1_32322001_1 - 4.6e-35 121.4 7.1 6e-35 121.0 7.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166797.1_32322001_1 - 1.3e-16 60.5 15.7 1.6e-16 60.2 15.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166797.1_32322001_1 - 0.00069 18.8 13.1 0.0012 18.0 13.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Cytochrom_B_N_2 PF13631.4 001166797.1_32322001_1 - 1.7 8.5 9.8 0.084 12.7 1.1 2.7 2 1 1 3 3 3 0 Cytochrome b(N-terminal)/b6/petB V1R PF03402.12 001167326.1_37922001_1 - 4.3e-32 111.6 16.3 7e-32 111.0 16.3 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167326.1_37922001_1 - 2.4e-05 23.6 11.3 2.4e-05 23.6 11.3 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167326.1_37922001_1 - 0.0011 18.0 19.0 0.0014 17.6 19.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF2157 PF09925.7 001167326.1_37922001_1 - 0.28 10.8 4.6 0.21 11.2 2.4 1.8 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) Trypsin PF00089.24 001159810.1_43522001_1 - 3.1e-67 226.5 0.0 3.6e-67 226.3 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001159810.1_43522001_1 - 1.8e-05 25.5 0.0 3.3e-05 24.7 0.0 1.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001159810.1_43522001_1 - 0.00036 20.8 1.0 0.0017 18.6 1.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) V1R PF03402.12 001166798.1_32322001_1 - 4.1e-34 118.3 13.4 5.4e-34 117.9 13.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166798.1_32322001_1 - 5.3e-10 38.8 20.0 6.9e-10 38.4 20.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166798.1_32322001_1 - 7e-06 25.3 17.3 1e-05 24.8 17.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166799.1_32322001_1 - 4.1e-34 118.3 9.1 5.7e-34 117.8 9.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166799.1_32322001_1 - 6e-15 55.0 14.8 7.3e-15 54.7 14.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167328.1_37922001_1 - 3.8e-69 233.1 27.5 4.6e-69 232.8 27.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167328.1_37922001_1 - 0.00013 21.1 33.7 0.00015 20.9 33.7 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001166800.1_32322001_1 - 6.9e-27 94.6 16.5 1.1e-26 93.9 16.5 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166800.1_32322001_1 - 5.1e-06 25.7 15.9 6.5e-06 25.3 15.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166800.1_32322001_1 - 0.003 16.7 14.0 0.0042 16.2 14.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4728 PF15860.3 001166800.1_32322001_1 - 0.31 11.5 8.9 1.7 9.1 0.2 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4728) 7tm_1 PF00001.19 001173403.1_09923001_1 - 3.6e-46 157.4 19.3 5.1e-46 156.9 19.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001173403.1_09923001_1 - 6.9e-06 25.5 15.8 1.8e-05 24.1 15.8 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001173403.1_09923001_1 - 0.0023 17.2 18.2 0.0058 15.9 18.2 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Piezo_RRas_bdg PF12166.6 001173403.1_09923001_1 - 0.084 12.0 0.9 3 6.9 0.4 2.3 2 0 0 2 2 2 0 Piezo non-specific cation channel, R-Ras-binding domain V1R PF03402.12 001167329.1_37922001_1 - 3.2e-40 138.3 16.7 3.9e-40 138.0 16.7 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167329.1_37922001_1 - 1.9e-06 27.1 17.3 2.8e-06 26.5 17.3 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167329.1_37922001_1 - 7.9e-05 21.9 20.0 0.00031 19.9 20.0 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GP4 PF03010.12 001167329.1_37922001_1 - 0.0088 15.8 0.3 0.026 14.3 0.1 1.9 2 0 0 2 2 2 1 GP4 V1R PF03402.12 001166801.1_32322001_1 - 2.6e-27 96.0 15.2 4.1e-27 95.3 15.2 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166801.1_32322001_1 - 1.2e-06 27.8 16.1 1.5e-06 27.4 16.1 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166801.1_32322001_1 - 0.00026 20.2 13.8 0.00037 19.7 13.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4728 PF15860.3 001166801.1_32322001_1 - 0.69 10.4 9.2 3.1 8.3 0.2 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4728) V1R PF03402.12 001167330.1_37922001_1 - 3e-34 118.7 11.2 4.2e-34 118.2 11.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167330.1_37922001_1 - 5.1e-09 35.5 13.6 6.1e-09 35.3 13.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167330.1_37922001_1 - 2.4e-06 26.8 8.8 3.6e-06 26.3 8.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167331.1_37922001_1 - 2.5e-29 102.6 14.1 3.2e-29 102.3 14.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167331.1_37922001_1 - 1.8e-07 30.4 17.4 2.1e-07 30.2 17.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167332.1_37922001_1 - 1.1e-32 113.6 15.6 1.8e-32 112.9 15.6 1.3 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167332.1_37922001_1 - 0.002 17.3 16.0 0.0031 16.7 16.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166803.1_32322001_1 - 4.2e-31 108.4 13.8 7.3e-31 107.6 13.8 1.4 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166803.1_32322001_1 - 4.4e-09 35.7 16.2 5.4e-09 35.4 16.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF4728 PF15860.3 001166803.1_32322001_1 - 0.054 14.0 4.5 7.4 7.1 0.2 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4728) V1R PF03402.12 001167333.1_37922001_1 - 9.7e-30 103.9 19.9 1.2e-29 103.7 19.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167333.1_37922001_1 - 9.6e-12 44.5 19.3 1.2e-11 44.2 19.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001166804.1_32322001_1 - 4.8e-29 101.7 14.2 7.7e-29 101.0 14.2 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166804.1_32322001_1 - 1.1e-07 31.2 13.4 1.4e-07 30.8 13.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166804.1_32322001_1 - 0.00045 19.4 11.6 0.00064 18.9 11.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4728 PF15860.3 001166804.1_32322001_1 - 0.75 10.3 7.9 4.5 7.8 0.1 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4728) V1R PF03402.12 001166805.1_32322001_1 - 2.6e-35 122.2 14.9 3.5e-35 121.8 14.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166805.1_32322001_1 - 8.2e-11 41.4 20.5 1.4e-10 40.7 20.5 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) DUF3871 PF12987.5 001166805.1_32322001_1 - 0.14 10.8 0.0 0.2 10.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3871) V1R PF03402.12 001166806.1_32322001_1 - 1.3e-28 100.3 15.0 3.4e-28 98.9 15.0 1.6 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166806.1_32322001_1 - 1.4e-08 34.1 15.7 1.8e-08 33.7 15.7 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166806.1_32322001_1 - 0.00023 20.4 13.1 0.00034 19.8 13.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3810 PF12725.5 001166806.1_32322001_1 - 0.12 11.6 1.1 0.22 10.7 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) V1R PF03402.12 001167336.1_37922001_1 - 7e-28 97.8 19.2 1.2e-27 97.0 19.2 1.3 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167336.1_37922001_1 - 4.8e-08 32.3 23.1 6.2e-08 32.0 23.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167336.1_37922001_1 - 1.1e-06 28.0 18.8 1.5e-06 27.5 18.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166807.1_32322001_1 - 3.5e-37 128.3 8.2 5e-37 127.8 8.2 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166807.1_32322001_1 - 5.3e-13 48.6 11.1 6.6e-13 48.3 11.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001166808.1_32322001_1 - 4.3e-35 121.5 16.4 5.7e-35 121.1 16.4 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166808.1_32322001_1 - 4.8e-15 55.3 20.2 5.5e-15 55.1 20.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166808.1_32322001_1 - 0.0039 16.3 15.3 0.0055 15.9 15.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4133 PF13571.4 001166808.1_32322001_1 - 0.24 11.6 3.4 0.27 11.5 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4133) V1R PF03402.12 001167338.1_37922001_1 - 2.4e-66 223.9 28.9 3e-66 223.6 28.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167338.1_37922001_1 - 1.1e-07 31.2 35.1 1.4e-07 30.8 35.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167338.1_37922001_1 - 0.0055 15.9 25.2 0.0072 15.5 25.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166809.1_32322001_1 - 2.5e-32 112.4 12.0 3e-32 112.2 12.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166809.1_32322001_1 - 1.5e-08 34.0 15.1 1.8e-08 33.7 15.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167339.1_37922001_1 - 6.9e-31 107.7 13.1 9e-31 107.3 13.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167339.1_37922001_1 - 1.8e-08 33.7 12.6 2e-08 33.6 12.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167339.1_37922001_1 - 7.1e-06 25.3 10.4 1e-05 24.8 10.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166810.1_32322001_1 - 5e-29 101.6 16.9 8.3e-29 100.9 16.9 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001166810.1_32322001_1 - 0.00072 18.7 13.6 0.00097 18.3 13.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4728 PF15860.3 001166810.1_32322001_1 - 0.55 10.7 5.4 5.7 7.5 2.2 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4728) V1R PF03402.12 001166811.1_32322001_1 - 4.3e-29 101.8 15.2 9e-29 100.8 15.2 1.5 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166811.1_32322001_1 - 7.8e-10 38.2 14.8 9.8e-10 37.9 14.8 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166811.1_32322001_1 - 0.0003 20.0 14.2 0.00041 19.5 14.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4728 PF15860.3 001166811.1_32322001_1 - 0.063 13.7 5.9 5.3 7.6 1.5 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4728) V1R PF03402.12 001167341.1_37922001_1 - 6.8e-30 104.5 11.6 8.7e-30 104.1 11.6 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167341.1_37922001_1 - 4.2e-13 48.9 8.6 5.2e-13 48.6 8.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167341.1_37922001_1 - 1.2e-09 37.7 12.2 1.6e-09 37.3 12.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MMPL PF03176.13 001167341.1_37922001_1 - 0.02 13.7 1.0 0.034 12.9 0.3 1.7 2 0 0 2 2 2 0 MMPL family 7TM_GPCR_Srd PF10317.7 001167341.1_37922001_1 - 0.065 12.3 15.1 0.21 10.6 15.1 2.1 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srd TMEM138 PF14935.4 001167341.1_37922001_1 - 5.9 7.4 9.6 0.18 12.3 1.6 2.3 2 0 0 2 2 2 0 Transmembrane protein 138 V1R PF03402.12 001166812.1_32322001_1 - 5.6e-31 108.0 16.0 1.5e-30 106.5 16.0 1.6 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166812.1_32322001_1 - 3.3e-09 36.1 18.3 4.2e-09 35.8 18.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166812.1_32322001_1 - 0.00043 19.5 14.3 0.00061 19.0 14.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4728 PF15860.3 001166812.1_32322001_1 - 0.54 10.8 6.6 14 6.2 1.5 3.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4728) V1R PF03402.12 001166813.1_32322001_1 - 3.2e-33 115.4 13.7 6.1e-33 114.4 13.7 1.4 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166813.1_32322001_1 - 1.2e-08 34.4 15.9 1.6e-08 33.9 15.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166813.1_32322001_1 - 0.0004 19.6 13.7 0.00055 19.1 13.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4728 PF15860.3 001166813.1_32322001_1 - 0.45 11.0 5.5 5.2 7.6 1.6 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4728) V1R PF03402.12 001167345.1_37922001_1 - 2.7e-37 128.7 12.6 3.6e-37 128.3 12.6 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167345.1_37922001_1 - 3.4e-07 29.5 11.9 4.8e-07 29.0 11.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167345.1_37922001_1 - 2e-06 27.1 11.5 2.7e-06 26.7 11.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166814.1_32322001_1 - 1.9e-31 109.5 14.8 3e-31 108.9 14.8 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166814.1_32322001_1 - 3.8e-11 42.5 15.9 4.9e-11 42.2 15.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166814.1_32322001_1 - 0.0026 16.9 15.3 0.0041 16.2 15.3 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4728 PF15860.3 001166814.1_32322001_1 - 0.075 13.5 3.5 6.7 7.2 0.4 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4728) DUF3810 PF12725.5 001166814.1_32322001_1 - 7.8 5.6 8.4 0.13 11.5 0.7 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3810) 7tm_1 PF00001.19 001173414.1_09923001_1 - 3.9e-46 157.3 13.3 4.8e-46 157.0 13.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001173414.1_09923001_1 - 4.9e-11 42.4 19.8 4.7e-08 32.6 13.5 2.5 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.7 001173414.1_09923001_1 - 0.0019 17.4 15.7 0.002 17.4 12.4 2.4 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.7 001173414.1_09923001_1 - 0.0056 15.9 17.2 0.0056 15.9 17.2 2.1 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx V1R PF03402.12 001166815.1_32322001_1 - 2.3e-29 102.7 16.2 3.4e-29 102.2 16.2 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166815.1_32322001_1 - 4.5e-07 29.2 15.0 5.5e-07 28.9 15.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166815.1_32322001_1 - 2.1e-05 23.7 12.3 2.8e-05 23.3 12.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4728 PF15860.3 001166815.1_32322001_1 - 0.14 12.6 7.7 1.2 9.7 0.1 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4728) V1R PF03402.12 001166816.1_32322001_1 - 4.3e-27 95.3 7.6 8.1e-27 94.4 7.6 1.4 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001166816.1_32322001_1 - 0.014 14.5 9.6 0.058 12.5 9.6 1.9 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166817.1_32322001_1 - 2.3e-31 109.3 13.5 4.6e-31 108.3 13.5 1.5 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166817.1_32322001_1 - 1e-07 31.3 15.3 1.2e-07 31.0 15.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF3810 PF12725.5 001166817.1_32322001_1 - 6 6.0 11.7 0.13 11.5 2.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) V1R PF03402.12 001167346.1_37922001_1 - 6.5e-38 130.7 11.4 8.6e-38 130.3 11.4 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167346.1_37922001_1 - 3.1e-08 33.1 10.5 4.2e-08 32.6 10.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167346.1_37922001_1 - 3.1e-07 29.7 11.5 4.7e-07 29.1 11.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Reprolysin PF01421.17 001195734.1_29628001_3 - 7.3e-71 238.1 1.7 1.4e-70 237.2 1.1 1.8 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 001195734.1_29628001_3 - 2.8e-31 108.2 7.2 2.8e-31 108.2 7.2 2.8 3 1 0 3 3 2 1 ADAM cysteine-rich Disintegrin PF00200.21 001195734.1_29628001_3 - 2.5e-18 66.5 27.7 2.5e-18 66.5 27.7 4.1 4 1 0 4 4 2 1 Disintegrin Pep_M12B_propep PF01562.17 001195734.1_29628001_3 - 7.4e-18 65.0 0.2 1.3e-17 64.2 0.2 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 001195734.1_29628001_3 - 1.1e-10 41.8 3.9 2.3e-10 40.8 3.9 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 001195734.1_29628001_3 - 1.5e-10 41.5 0.3 3.3e-10 40.4 0.3 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001195734.1_29628001_3 - 3.1e-05 23.6 0.7 5.4e-05 22.8 0.7 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.11 001195734.1_29628001_3 - 0.003 17.7 9.0 0.003 17.7 9.0 4.8 6 0 0 6 6 3 1 EGF-like domain Astacin PF01400.22 001195734.1_29628001_3 - 0.0047 16.4 0.3 0.01 15.3 0.3 1.5 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M57 PF12388.6 001195734.1_29628001_3 - 0.098 12.1 0.1 0.2 11.1 0.1 1.4 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Reprolysin_2 PF13574.4 001195734.1_29628001_3 - 0.17 11.6 1.7 0.32 10.7 1.7 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.22 001195734.1_29628001_3 - 1.3 8.7 5.9 2.8 7.7 5.9 1.4 1 1 0 1 1 1 0 Matrixin V1R PF03402.12 001166818.1_32322001_1 - 4e-26 92.1 6.5 7.5e-26 91.2 6.5 1.4 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001166818.1_32322001_1 - 0.004 16.3 8.7 0.016 14.3 8.7 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166819.1_32322001_1 - 2.4e-27 96.1 5.5 4.2e-27 95.3 5.5 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001166819.1_32322001_1 - 0.0058 15.8 7.8 0.032 13.3 7.8 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166820.1_32322001_1 - 1.9e-30 106.2 12.5 4e-30 105.2 12.5 1.5 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166820.1_32322001_1 - 1.2e-08 34.3 13.6 1.5e-08 34.0 13.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166820.1_32322001_1 - 0.0003 20.0 14.4 0.00038 19.7 14.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3810 PF12725.5 001166820.1_32322001_1 - 1.2 8.3 9.7 0.03 13.5 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) V1R PF03402.12 001166821.1_32322001_1 - 4.1e-33 115.0 13.9 5.2e-33 114.7 13.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166821.1_32322001_1 - 4.4e-10 39.0 23.3 5.3e-10 38.8 23.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166821.1_32322001_1 - 0.028 13.5 12.9 0.039 13.1 12.9 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166822.1_32322001_1 - 9.6e-32 110.5 15.1 2e-31 109.4 15.1 1.5 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166822.1_32322001_1 - 2.8e-09 36.4 15.4 3.4e-09 36.1 15.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166822.1_32322001_1 - 0.0033 16.6 13.5 0.0049 16.0 13.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3810 PF12725.5 001166822.1_32322001_1 - 0.31 10.2 1.4 0.53 9.5 1.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) S4 PF01479.23 001171394.1_37922001_1 - 1.6e-11 43.6 1.8 4.3e-11 42.2 1.8 1.8 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.17 001171394.1_37922001_1 - 7.4e-06 26.7 0.8 1.3e-05 26.0 0.1 1.8 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain V1R PF03402.12 001166823.1_32322001_1 - 1.5e-29 103.3 14.4 3.3e-29 102.2 14.4 1.5 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166823.1_32322001_1 - 2.2e-07 30.1 14.2 2.7e-07 29.9 14.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166823.1_32322001_1 - 0.0026 16.9 12.0 0.0037 16.4 12.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4728 PF15860.3 001166823.1_32322001_1 - 0.097 13.1 5.0 3.5 8.1 1.3 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4728) V1R PF03402.12 001166824.1_32322001_1 - 2.5e-35 122.3 16.0 3.3e-35 121.9 16.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166824.1_32322001_1 - 1.2e-10 40.9 21.7 1.9e-10 40.2 21.7 1.2 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) DUF3871 PF12987.5 001166824.1_32322001_1 - 0.13 10.9 0.0 0.19 10.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3871) V1R PF03402.12 001166825.1_32323001_1 - 5e-31 108.2 23.0 7.4e-31 107.6 23.0 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166825.1_32323001_1 - 3.3e-10 39.5 30.1 3.9e-10 39.2 30.1 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Gamma_PGA_hydro PF05908.9 001166825.1_32323001_1 - 0.09 12.0 0.1 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 Poly-gamma-glutamate hydrolase V1R PF03402.12 001166826.1_32322001_1 - 1.4e-31 109.9 22.5 2e-31 109.5 22.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166826.1_32322001_1 - 4e-10 39.2 29.9 4.9e-10 38.9 29.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166826.1_32322001_1 - 0.00062 18.9 21.2 0.00087 18.5 21.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Gamma_PGA_hydro PF05908.9 001166826.1_32322001_1 - 0.084 12.1 0.1 0.13 11.5 0.1 1.2 1 0 0 1 1 1 0 Poly-gamma-glutamate hydrolase V1R PF03402.12 001166827.1_32322001_1 - 8.1e-33 114.0 11.6 1.1e-32 113.6 11.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166827.1_32322001_1 - 4.9e-15 55.3 16.8 5.5e-15 55.1 16.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF3671 PF12420.6 001166827.1_32322001_1 - 1 9.3 4.3 3 7.8 2.5 2.5 2 1 0 2 2 2 0 Protein of unknown function V1R PF03402.12 001166829.1_32322001_1 - 7.1e-35 120.8 13.4 9.1e-35 120.4 13.4 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166829.1_32322001_1 - 6.5e-13 48.3 18.1 7.3e-13 48.2 18.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Homeobox PF00046.27 001171401.1_37922001_1 - 4.7e-22 77.4 8.0 7e-22 76.9 8.0 1.3 1 0 0 1 1 1 1 Homeobox domain Terminase_5 PF06056.10 001171401.1_37922001_1 - 0.014 15.1 1.5 0.14 11.9 0.3 2.2 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) DUF2209 PF09974.7 001171401.1_37922001_1 - 0.06 13.5 0.1 0.087 13.0 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) DUF739 PF05339.9 001171401.1_37922001_1 - 0.14 12.2 0.2 0.27 11.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF739) Homeobox_KN PF05920.9 001171401.1_37922001_1 - 0.63 9.9 3.8 0.2 11.5 0.7 1.7 2 0 0 2 2 2 0 Homeobox KN domain V1R PF03402.12 001166830.1_32322001_1 - 6.8e-35 120.8 12.0 9.3e-35 120.4 12.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166830.1_32322001_1 - 1.1e-12 47.6 14.6 1.2e-12 47.4 14.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001166831.1_32322001_1 - 4e-31 108.5 22.7 5.3e-31 108.1 22.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166831.1_32322001_1 - 2.2e-14 53.2 27.9 2.6e-14 52.9 27.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001166832.1_32322001_1 - 1.6e-32 113.0 11.4 2.3e-32 112.5 11.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166832.1_32322001_1 - 3e-15 56.0 19.0 3.6e-15 55.7 19.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166832.1_32322001_1 - 0.00025 20.3 14.6 0.00038 19.7 14.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166833.1_32322001_1 - 3.6e-35 121.7 10.1 5e-35 121.3 10.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166833.1_32322001_1 - 4.5e-15 55.4 17.5 5.5e-15 55.1 17.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166833.1_32322001_1 - 0.0039 16.3 13.4 0.0058 15.8 13.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001171423.1_37922001_1 - 2.4e-115 384.9 24.7 2.8e-115 384.7 24.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171423.1_37922001_1 - 1.6e-20 73.4 20.4 6.9e-20 71.3 20.4 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171423.1_37922001_1 - 2.5e-09 36.8 6.7 2.5e-09 36.8 6.7 2.1 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx V1R PF03402.12 001167194.1_37922001_1 - 2.5e-34 119.0 12.2 3.5e-34 118.5 12.2 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167194.1_37922001_1 - 1.4e-07 30.8 17.4 1.8e-07 30.5 17.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167194.1_37922001_1 - 6e-07 28.8 15.7 8.6e-07 28.3 15.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001171424.1_37922001_1 - 2.3e-115 385.0 23.2 2.7e-115 384.8 23.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171424.1_37922001_1 - 3.9e-18 65.5 23.4 1.6e-17 63.5 23.4 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171424.1_37922001_1 - 4.1e-08 32.8 12.4 7.4e-08 31.9 12.4 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171425.1_37922001_1 - 1.5e-112 375.8 20.7 1.8e-112 375.5 20.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171425.1_37922001_1 - 1.2e-18 67.3 19.9 3.7e-18 65.6 19.9 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171425.1_37922001_1 - 1.9e-08 33.9 11.0 1.9e-08 33.9 11.0 2.1 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx ATP_bind_1 PF03029.15 001171425.1_37922001_1 - 0.11 12.1 0.3 0.16 11.6 0.3 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein V1R PF03402.12 001167195.1_37922001_1 - 3.7e-30 105.3 19.1 4.5e-30 105.0 19.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167195.1_37922001_1 - 5e-12 45.4 19.3 6e-12 45.2 19.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Claudin_2 PF13903.4 001167195.1_37922001_1 - 0.012 15.2 7.3 0.024 14.2 7.3 1.6 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction 7tm_4 PF13853.4 001171426.1_37922001_1 - 2.1e-123 411.4 23.6 2.4e-123 411.2 23.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171426.1_37922001_1 - 2e-19 69.8 18.8 3.6e-19 68.9 18.8 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171426.1_37922001_1 - 1.9e-07 30.6 18.8 6.1e-07 28.9 17.3 2.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Serpentine_r_xa PF03383.13 001171426.1_37922001_1 - 0.0034 17.2 6.5 0.0034 17.2 6.5 3.4 1 1 3 4 4 4 1 Caenorhabditis serpentine receptor-like protein, class xa 7tm_4 PF13853.4 001171427.1_37922001_1 - 9.6e-109 363.3 22.8 1.1e-108 363.1 22.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171427.1_37922001_1 - 6.6e-21 74.6 19.8 1.2e-20 73.8 19.8 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171427.1_37922001_1 - 1.4e-05 24.5 18.9 3.1e-05 23.4 18.9 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171428.1_37922001_1 - 3.5e-113 377.8 23.3 4e-113 377.6 23.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171428.1_37922001_1 - 1.1e-20 73.9 23.4 1e-19 70.7 23.4 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171428.1_37922001_1 - 6.6e-11 41.9 9.8 1.2e-10 41.1 9.8 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171429.1_37922001_1 - 1.4e-114 382.4 23.2 1.6e-114 382.2 23.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171429.1_37922001_1 - 4.3e-19 68.7 21.6 6.8e-19 68.0 21.6 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171429.1_37922001_1 - 2.3e-06 27.0 16.8 7.5e-06 25.4 16.8 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171430.1_37922001_1 - 1.2e-113 379.4 24.1 1.3e-113 379.2 24.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171430.1_37922001_1 - 2.2e-20 72.9 23.6 3.7e-19 68.8 23.6 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171430.1_37922001_1 - 6.8e-11 41.9 7.9 6.8e-11 41.9 7.9 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171431.1_37922001_1 - 8.4e-85 284.7 12.0 1e-84 284.5 12.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171431.1_37922001_1 - 1.3e-17 63.8 13.7 6e-16 58.3 13.8 2.7 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171431.1_37922001_1 - 1.3e-07 31.1 4.1 1.3e-07 31.1 4.1 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.7 001171431.1_37922001_1 - 0.27 10.6 4.0 0.31 10.4 4.0 1.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc V1R PF03402.12 001167198.1_37922001_1 - 6.3e-29 101.3 19.5 7.9e-29 101.0 19.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167198.1_37922001_1 - 6.1e-11 41.8 20.7 7.3e-11 41.6 20.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167342.1_37923001_1 - 4.7e-102 341.0 22.1 5.8e-102 340.7 22.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167342.1_37923001_1 - 0.028 13.5 19.8 0.04 13.0 19.8 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001171432.1_37922001_1 - 3.8e-119 397.4 22.3 4.7e-119 397.1 22.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171432.1_37922001_1 - 1.2e-15 57.4 22.9 3.7e-15 55.8 22.9 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171432.1_37922001_1 - 8e-07 28.6 19.2 4.1e-06 26.2 19.2 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171433.1_37922001_1 - 1.5e-123 411.8 20.2 1.8e-123 411.6 20.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171433.1_37922001_1 - 2.4e-17 62.9 16.4 9e-17 61.0 16.4 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171433.1_37922001_1 - 0.00011 21.5 13.6 0.00018 20.8 13.6 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx V1R PF03402.12 001167199.1_37922001_1 - 1.7e-50 172.0 27.2 2.1e-50 171.7 27.2 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167199.1_37922001_1 - 5.2e-06 25.6 32.0 6.2e-06 25.4 32.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF2333 PF10095.7 001167199.1_37922001_1 - 0.09 11.7 1.3 3.4 6.5 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2333) V1R PF03402.12 001167259.1_37923001_1 - 9.6e-102 340.0 23.1 1.2e-101 339.7 23.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167259.1_37923001_1 - 0.02 14.0 21.7 0.021 13.9 20.9 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001171434.1_37922001_1 - 1.2e-115 385.9 27.0 1.4e-115 385.7 27.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171434.1_37922001_1 - 2.3e-19 69.5 20.3 3.7e-19 68.9 20.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171434.1_37922001_1 - 1.1e-09 37.9 19.5 3.1e-09 36.5 19.5 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171435.1_37922001_1 - 7.2e-140 465.4 19.9 8.2e-140 465.2 19.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171435.1_37922001_1 - 1.8e-22 79.7 14.2 3.1e-22 79.0 14.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171435.1_37922001_1 - 3e-06 26.7 14.1 6.9e-06 25.5 14.1 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171436.1_37922001_1 - 4.3e-129 430.0 27.2 5.3e-129 429.7 27.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171436.1_37922001_1 - 7.4e-21 74.4 20.4 1.3e-20 73.7 20.4 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171436.1_37922001_1 - 4.3e-07 29.5 13.5 6.5e-07 28.9 13.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171437.1_37922001_1 - 3.1e-121 404.2 22.8 3.7e-121 404.0 22.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171437.1_37922001_1 - 4.6e-20 71.8 21.5 9.3e-20 70.8 21.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171437.1_37922001_1 - 2.9e-10 39.8 17.7 3.8e-10 39.5 17.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Interferon PF00143.17 001166310.1_49822001_1 - 1.7e-66 223.2 0.5 1.9e-66 223.1 0.5 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain 7tm_4 PF13853.4 001171439.1_37922001_1 - 1.4e-121 405.4 24.5 1.7e-121 405.1 24.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171439.1_37922001_1 - 2.4e-16 59.6 24.2 5.8e-16 58.4 24.2 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171439.1_37922001_1 - 0.0018 17.6 22.0 0.0025 17.1 22.0 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx V1R PF03402.12 001167202.1_37922001_1 - 2.5e-38 132.1 16.1 3.6e-38 131.6 16.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167202.1_37922001_1 - 2.1e-12 46.6 26.0 2.7e-12 46.3 26.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167202.1_37922001_1 - 0.00022 20.4 16.3 0.00031 19.9 16.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-DHHC PF01529.18 001167202.1_37922001_1 - 0.0084 16.1 4.6 0.0084 16.1 4.6 2.9 1 1 1 3 3 3 1 DHHC palmitoyltransferase 7tm_4 PF13853.4 001171441.1_37922001_1 - 9.1e-132 438.8 22.4 1.1e-131 438.6 22.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171441.1_37922001_1 - 1.2e-14 54.1 24.3 5.2e-14 52.0 24.3 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171441.1_37922001_1 - 1.3e-06 27.8 15.8 2e-06 27.3 15.9 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171442.1_37922001_1 - 8.2e-132 438.9 23.3 9.4e-132 438.8 23.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171442.1_37922001_1 - 9.6e-15 54.4 23.4 4.3e-14 52.3 23.4 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171442.1_37922001_1 - 1e-06 28.2 13.0 1e-06 28.2 13.0 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171443.1_37922001_1 - 4.8e-121 403.6 23.4 5.6e-121 403.4 23.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171443.1_37922001_1 - 7.1e-17 61.4 23.4 2.6e-16 59.5 23.4 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171443.1_37922001_1 - 2.5e-08 33.5 17.8 7.8e-08 31.9 17.8 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171444.1_37922001_1 - 4.9e-54 183.8 9.1 6e-54 183.5 9.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171444.1_37922001_1 - 1.2e-14 54.1 3.3 1.2e-14 54.1 3.3 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171444.1_37922001_1 - 2.9e-08 33.3 4.7 3.8e-08 32.9 4.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.7 001171444.1_37922001_1 - 0.0028 17.1 4.7 0.0028 17.1 4.7 1.4 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_4 PF13853.4 001171445.1_37922001_1 - 3.1e-117 391.1 27.8 3.7e-117 390.9 27.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171445.1_37922001_1 - 5.1e-16 58.6 22.2 9.6e-16 57.7 22.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171445.1_37922001_1 - 1.2e-07 31.2 16.1 5.3e-07 29.1 16.1 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx V1R PF03402.12 001167204.1_37922001_1 - 1e-37 130.1 13.6 1.3e-37 129.8 13.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167204.1_37922001_1 - 5.7e-13 48.5 20.2 6.9e-13 48.2 20.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167204.1_37922001_1 - 0.0027 16.9 16.5 0.0042 16.2 16.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Shisa PF13908.4 001167204.1_37922001_1 - 0.31 11.1 0.0 0.31 11.1 0.0 1.8 2 1 0 2 2 2 0 Wnt and FGF inhibitory regulator 7tm_4 PF13853.4 001171446.1_37922001_1 - 5.5e-99 331.3 23.6 6.6e-99 331.0 23.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171446.1_37922001_1 - 2.5e-18 66.1 23.5 7.3e-18 64.6 23.5 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171446.1_37922001_1 - 1.2e-06 28.0 7.9 1.2e-06 28.0 7.9 1.9 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF2304 PF10066.7 001171446.1_37922001_1 - 0.033 14.3 0.8 0.033 14.3 0.8 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) 7tm_4 PF13853.4 001171447.1_37922001_1 - 7.1e-116 386.7 28.6 8.5e-116 386.4 28.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171447.1_37922001_1 - 1.9e-16 60.0 24.2 3.4e-16 59.2 24.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171447.1_37922001_1 - 1.1e-06 28.1 18.5 2.9e-06 26.7 18.5 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx V1R PF03402.12 001167205.1_37922001_1 - 4.3e-62 210.0 33.3 5.5e-62 209.7 33.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167205.1_37922001_1 - 3.6e-06 26.2 37.5 4.3e-06 25.9 37.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167205.1_37922001_1 - 7.8e-05 21.9 24.8 0.00011 21.5 24.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001171448.1_37922001_1 - 8.3e-101 337.2 17.5 9.6e-101 337.0 17.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171448.1_37922001_1 - 7.1e-21 74.5 22.1 2.9e-20 72.5 22.1 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171448.1_37922001_1 - 4.6e-08 32.6 3.4 4.6e-08 32.6 3.4 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171449.1_37922001_1 - 6.7e-105 350.7 19.2 7.8e-105 350.4 19.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171449.1_37922001_1 - 9.7e-23 80.6 14.2 1.8e-22 79.8 14.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171449.1_37922001_1 - 4.3e-08 32.7 15.4 8e-08 31.8 13.5 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001171449.1_37922001_1 - 0.0004 19.7 8.3 0.0004 19.7 8.3 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001171450.1_37922001_1 - 6.1e-114 380.3 25.8 7.5e-114 380.0 25.8 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171450.1_37922001_1 - 3.3e-19 69.0 22.9 9.2e-19 67.6 22.9 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171450.1_37922001_1 - 2.9e-07 30.0 20.2 8.1e-07 28.5 20.2 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171451.1_37922001_1 - 2.2e-105 352.3 28.5 2.6e-105 352.0 28.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171451.1_37922001_1 - 3.5e-21 75.5 27.7 7.5e-21 74.4 27.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171451.1_37922001_1 - 3.1e-09 36.4 17.6 3.1e-09 36.4 17.6 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171452.1_37922001_1 - 1.9e-101 339.3 25.0 2.2e-101 339.2 25.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171452.1_37922001_1 - 4.3e-14 52.3 24.7 1.9e-13 50.1 24.7 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171452.1_37922001_1 - 1.6e-06 27.5 20.1 3e-06 26.7 20.1 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Mob1_phocein PF03637.15 001171452.1_37922001_1 - 4.1 7.3 7.8 0.59 10.0 0.4 2.3 1 1 1 2 2 2 0 Mob1/phocein family 7tm_4 PF13853.4 001171453.1_37922001_1 - 1.3e-98 330.1 22.3 1.6e-98 329.8 22.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171453.1_37922001_1 - 5.5e-15 55.2 23.4 1.6e-14 53.7 23.4 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171453.1_37922001_1 - 2.3e-09 36.9 14.9 2.3e-09 36.9 14.9 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx V1R PF03402.12 001167209.1_37922001_1 - 3e-32 112.2 14.4 4.3e-32 111.7 14.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167209.1_37922001_1 - 4e-11 42.4 15.3 4.8e-11 42.2 15.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167209.1_37922001_1 - 0.0051 15.9 12.1 0.0086 15.2 12.1 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001171455.1_37922001_1 - 1.5e-114 382.3 23.3 1.8e-114 382.1 23.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171455.1_37922001_1 - 1e-18 67.4 21.8 7.8e-18 64.5 21.8 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171455.1_37922001_1 - 1.5e-05 24.4 14.3 0.00011 21.6 14.3 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171456.1_37922001_1 - 1e-113 379.6 22.7 1.2e-113 379.3 22.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171456.1_37922001_1 - 5.9e-24 84.6 20.5 1.5e-23 83.3 20.5 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171456.1_37922001_1 - 7.4e-08 31.9 17.7 2.5e-07 30.2 17.7 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171457.1_37922001_1 - 3.3e-147 489.5 17.8 3.8e-147 489.3 17.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171457.1_37922001_1 - 1.8e-19 69.9 12.3 6.7e-19 68.0 12.3 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171457.1_37922001_1 - 2.2e-08 33.7 7.1 2.2e-08 33.7 7.1 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.7 001171457.1_37922001_1 - 0.0001 21.8 7.2 0.00017 21.1 7.2 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srx PF10328.7 001171457.1_37922001_1 - 0.00044 19.5 11.4 0.00044 19.5 11.4 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx V1R PF03402.12 001167211.1_37922001_1 - 4.9e-39 134.4 15.6 6.7e-39 134.0 15.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167211.1_37922001_1 - 7.4e-09 35.0 25.4 8.6e-09 34.8 25.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167211.1_37922001_1 - 0.00023 20.3 16.5 0.00033 19.9 16.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-DHHC PF01529.18 001167211.1_37922001_1 - 0.014 15.3 3.2 0.014 15.3 3.2 2.9 2 1 1 3 3 3 0 DHHC palmitoyltransferase Vpu PF00558.17 001167211.1_37922001_1 - 0.088 12.5 0.3 0.23 11.1 0.3 1.6 1 0 0 1 1 1 0 Vpu protein 7tm_1 PF00001.19 001198946.1_37923001_1 - 1.5e-40 139.0 19.8 2.3e-40 138.4 19.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001198946.1_37923001_1 - 6.8e-07 28.8 22.6 9e-07 28.4 22.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001198946.1_37923001_1 - 0.00042 20.0 20.0 0.0013 18.3 20.0 1.8 1 1 0 1 1 1 1 Olfactory receptor JTB PF05439.10 001198946.1_37923001_1 - 0.017 15.0 0.9 0.055 13.4 0.9 1.8 1 0 0 1 1 1 0 Jumping translocation breakpoint protein (JTB) 7tm_4 PF13853.4 001171458.1_37922001_1 - 4.2e-114 380.8 22.4 5e-114 380.6 22.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171458.1_37922001_1 - 2.4e-17 62.9 21.3 1.2e-16 60.6 21.3 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171458.1_37922001_1 - 2e-08 33.8 7.7 2e-08 33.8 7.7 2.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171459.1_37922001_1 - 1.5e-119 398.7 21.2 1.8e-119 398.5 21.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171459.1_37922001_1 - 2.7e-15 56.2 20.1 9.4e-15 54.4 20.1 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171459.1_37922001_1 - 9.2e-08 31.6 3.5 9.2e-08 31.6 3.5 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001171459.1_37922001_1 - 3.7 6.6 19.6 0.13 11.4 11.3 2.1 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx SLC3A2_N PF16028.3 001171459.1_37922001_2 - 0.0019 17.5 5.1 0.0033 16.8 5.1 1.3 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus V1R PF03402.12 001167212.1_37922001_1 - 2.7e-35 122.1 13.8 3.7e-35 121.7 13.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167212.1_37922001_1 - 1.1 8.3 15.2 2.7 7.0 15.2 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) VPEP PF07589.9 001167212.1_37922001_1 - 9.7 6.3 8.2 19 5.4 0.1 3.5 3 0 0 3 3 3 0 PEP-CTERM motif 7tm_4 PF13853.4 001171460.1_37922001_1 - 3.3e-121 404.2 21.9 3.8e-121 404.0 21.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171460.1_37922001_1 - 4.4e-21 75.2 21.6 8.8e-21 74.2 21.6 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171460.1_37922001_1 - 5.9e-07 29.0 20.2 1.5e-06 27.7 20.2 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171461.1_37922001_1 - 1.7e-122 408.4 19.4 2e-122 408.2 19.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171461.1_37922001_1 - 2.9e-21 75.8 19.4 7.6e-21 74.4 19.4 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171461.1_37922001_1 - 2.3e-08 33.6 14.9 4.2e-08 32.7 14.9 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1304 PF06993.10 001171461.1_37922001_1 - 0.8 9.6 5.2 0.24 11.3 0.6 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1304) 7tm_4 PF13853.4 001171462.1_37922001_1 - 2e-122 408.2 22.4 2.4e-122 407.9 22.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171462.1_37922001_1 - 4.7e-23 81.6 21.3 9.4e-23 80.6 21.3 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171462.1_37922001_1 - 1.3e-06 27.8 18.3 2.7e-06 26.8 18.3 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171463.1_37922001_1 - 1.2e-119 399.1 25.6 1.5e-119 398.7 25.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171463.1_37922001_1 - 1.2e-21 77.0 25.2 2.2e-21 76.1 25.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171463.1_37922001_1 - 8.4e-08 31.8 24.7 2.7e-07 30.1 24.7 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171464.1_37922001_1 - 1.6e-118 395.4 26.9 1.8e-118 395.2 26.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171464.1_37922001_1 - 1e-23 83.8 25.0 1.8e-23 83.0 25.0 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171464.1_37922001_1 - 8.5e-09 35.0 26.6 3.7e-08 32.9 26.6 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Serpentine_r_xa PF03383.13 001171464.1_37922001_1 - 0.0097 15.8 6.9 0.0097 15.8 6.9 2.5 1 1 0 2 2 2 1 Caenorhabditis serpentine receptor-like protein, class xa V1R PF03402.12 001167215.1_37922001_1 - 8.8e-36 123.7 17.8 1.3e-35 123.2 17.8 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167215.1_37922001_1 - 4.7e-13 48.8 29.0 5.7e-13 48.5 29.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167215.1_37922001_1 - 4.5e-05 22.7 16.5 6.6e-05 22.1 16.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DctQ PF04290.10 001167215.1_37922001_1 - 0.031 14.1 0.9 0.031 14.1 0.9 3.0 2 2 1 3 3 3 0 Tripartite ATP-independent periplasmic transporters, DctQ component DUF2569 PF10754.7 001167215.1_37922001_1 - 0.28 11.5 20.5 0.096 13.0 7.8 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF2569) 7tm_4 PF13853.4 001171465.1_37922001_1 - 1.2e-111 372.8 28.2 1.4e-111 372.5 28.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171465.1_37922001_1 - 3.9e-22 78.6 24.1 7.3e-22 77.7 24.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171465.1_37922001_1 - 6.8e-07 28.8 18.2 2.3e-06 27.1 18.2 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171466.1_37922001_1 - 7.2e-109 363.7 21.0 8.4e-109 363.5 21.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171466.1_37922001_1 - 1.3e-20 73.6 19.6 5.5e-20 71.6 19.6 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171466.1_37922001_1 - 9.1e-10 38.2 14.6 1.2e-09 37.8 14.4 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171467.1_37922001_1 - 2.2e-109 365.3 19.4 2.7e-109 365.1 19.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171467.1_37922001_1 - 5.9e-21 74.8 19.2 1.6e-20 73.4 19.2 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171467.1_37922001_1 - 2.4e-09 36.8 12.5 2.4e-09 36.8 12.5 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx ubiquitin PF00240.21 001171468.1_37924001_1 - 2.7e-18 65.3 0.3 5.4e-18 64.4 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.29 001171468.1_37924001_1 - 3.4e-06 26.7 0.1 1.1e-05 25.1 0.1 1.9 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.6 001171468.1_37924001_1 - 1.6e-05 24.5 0.2 2.6e-05 23.8 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.4 001171468.1_37924001_1 - 0.0026 17.7 0.0 0.0063 16.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001171468.1_37924001_1 - 0.0055 17.1 0.0 0.013 15.9 0.0 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain YukD PF08817.8 001171468.1_37924001_1 - 0.0089 16.6 0.0 0.025 15.1 0.0 1.8 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD YopE_N PF09020.8 001171468.1_37924001_1 - 0.042 14.0 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 YopE, N terminal HOIP-UBA PF16678.3 001171468.1_37924001_1 - 0.15 11.9 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase V1R PF03402.12 001167217.1_37922001_1 - 3.3e-64 216.9 32.8 4.1e-64 216.6 32.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_4 PF13853.4 001171470.1_37922001_1 - 3.4e-108 361.5 25.1 3.9e-108 361.3 25.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171470.1_37922001_1 - 4.1e-20 72.0 27.0 1.3e-19 70.4 27.0 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171470.1_37922001_1 - 2.4e-06 27.0 22.9 4.5e-06 26.1 22.9 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1418 PF07214.10 001171470.1_37922001_1 - 1.4 8.8 4.5 4.4 7.1 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1418) 7tm_4 PF13853.4 001171473.1_37922001_1 - 8.3e-102 340.5 25.2 1e-101 340.2 25.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171473.1_37922001_1 - 1.4e-17 63.7 25.7 3.2e-17 62.5 25.7 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171473.1_37922001_1 - 6.6e-10 38.7 23.6 2e-09 37.1 23.6 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx V1R PF03402.12 001167220.1_37922001_1 - 6e-37 127.6 17.8 7.8e-37 127.2 17.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167220.1_37922001_1 - 4.4e-11 42.3 26.9 5.3e-11 42.0 26.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167220.1_37922001_1 - 0.00019 20.6 16.7 0.00028 20.1 16.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001171475.1_37922001_1 - 8.3e-106 353.6 17.6 1.1e-105 353.3 17.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171475.1_37922001_1 - 8.5e-21 74.2 17.4 1.6e-20 73.3 17.4 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171475.1_37922001_1 - 1.2e-09 37.8 8.0 1.2e-09 37.8 8.0 1.6 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.7 001171475.1_37922001_1 - 0.00062 19.2 5.7 0.0011 18.4 5.7 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_4 PF13853.4 001171476.1_37922001_1 - 1.6e-105 352.7 17.5 1.8e-105 352.5 17.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171476.1_37922001_1 - 8.1e-19 67.8 17.3 1.7e-18 66.7 17.3 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171476.1_37922001_1 - 3.3e-10 39.7 15.1 4.7e-10 39.1 14.4 1.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4083 PF13314.4 001171476.1_37922001_1 - 2.3 8.1 4.4 0.89 9.4 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) V1R PF03402.12 001167222.1_37922001_1 - 3.5e-35 121.8 11.7 4.8e-35 121.3 11.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167222.1_37922001_1 - 1.1e-08 34.4 12.0 1.4e-08 34.1 12.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167222.1_37922001_1 - 1.6e-06 27.5 8.5 2.2e-06 27.0 8.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Cation_ATPase_C PF00689.19 001167222.1_37922001_1 - 2.6 7.6 8.2 0.39 10.3 4.1 1.6 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus 7tm_4 PF13853.4 001171477.1_37922001_1 - 1.8e-106 355.8 19.5 2.2e-106 355.6 19.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171477.1_37922001_1 - 1.9e-19 69.8 18.9 4e-19 68.7 18.9 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171477.1_37922001_1 - 9.3e-11 41.5 16.5 1.3e-10 41.0 15.8 1.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx DNA_ligase_A_N PF04675.12 001171477.1_37922001_1 - 0.036 14.3 0.0 0.056 13.6 0.0 1.2 1 0 0 1 1 1 0 DNA ligase N terminus DUF4083 PF13314.4 001171477.1_37922001_1 - 4.5 7.2 5.2 0.94 9.3 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) V1R PF03402.12 001167223.1_37922001_1 - 2.2e-52 178.2 22.1 2.7e-52 177.9 22.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167223.1_37922001_1 - 0.0016 17.6 19.5 0.0023 17.1 19.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167223.1_37922001_1 - 0.0018 17.3 26.5 0.0024 16.9 26.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167224.1_37922001_1 - 2.3e-29 102.7 18.6 3.2e-29 102.3 18.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167224.1_37922001_1 - 1.9e-10 40.3 20.1 2e-10 40.1 20.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167224.1_37922001_1 - 0.00038 19.6 16.8 0.00064 18.9 16.8 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4321 PF14209.4 001171276.1_37922001_1 - 0.5 10.1 0.1 0.5 10.1 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4321) V1R PF03402.12 001167225.1_37922001_1 - 1.5e-29 103.3 18.2 2e-29 102.9 18.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167225.1_37922001_1 - 3.5e-10 39.3 19.7 3.8e-10 39.2 19.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167225.1_37922001_1 - 0.0018 17.4 15.6 0.0029 16.8 15.2 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167226.1_37922001_1 - 2.8e-42 145.0 20.2 4.1e-42 144.5 20.2 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167226.1_37922001_1 - 1.7e-14 53.5 31.6 1.9e-14 53.3 31.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167226.1_37922001_1 - 2e-06 27.1 19.1 3e-06 26.6 19.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001167226.1_37922001_1 - 0.11 11.7 24.7 0.18 11.0 23.9 1.8 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv TRAM1 PF08390.9 001167226.1_37922001_1 - 5.2 6.7 9.2 0.14 11.7 1.3 2.4 2 0 0 2 2 2 0 TRAM1-like protein 7tm_1 PF00001.19 001198958.1_37923001_1 - 2.2e-29 102.4 26.7 3.3e-29 101.8 24.3 2.2 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001198958.1_37923001_1 - 3.7e-06 26.4 10.6 7.9e-06 25.3 10.6 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001198958.1_37923001_1 - 0.00044 19.9 15.0 0.0049 16.5 2.4 2.2 2 0 0 2 2 2 2 Olfactory receptor V1R PF03402.12 001167349.1_37922001_1 - 2e-35 122.6 10.2 2.8e-35 122.1 10.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167349.1_37922001_1 - 1.3e-09 37.5 13.1 1.5e-09 37.3 13.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167349.1_37922001_1 - 0.0038 16.4 10.8 0.0085 15.2 10.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167228.1_37922001_1 - 4e-30 105.2 20.1 5.6e-30 104.7 20.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167228.1_37922001_1 - 9.4e-12 44.5 22.8 1.1e-11 44.3 22.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167228.1_37922001_1 - 0.00032 19.9 16.8 0.00054 19.1 16.8 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Globin PF00042.20 001171415.1_37921001_1 - 2.7e-28 98.6 0.0 3.5e-28 98.2 0.0 1.2 1 0 0 1 1 1 1 Globin V1R PF03402.12 001167233.1_37922001_1 - 1.8e-34 119.5 13.2 2.3e-34 119.1 13.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167233.1_37922001_1 - 3.6e-12 45.9 10.1 4.8e-12 45.5 10.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167233.1_37922001_1 - 1.4e-10 40.8 10.4 1.7e-10 40.4 10.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GP4 PF03010.12 001167233.1_37922001_1 - 0.03 14.1 0.2 0.067 13.0 0.2 1.6 1 0 0 1 1 1 0 GP4 HMG_box PF00505.17 001171148.1_37922001_1 - 4.2e-26 91.0 5.2 6.8e-26 90.4 5.2 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001171148.1_37922001_1 - 5.3e-09 36.4 5.4 5.3e-09 36.4 5.4 2.1 2 0 0 2 2 2 1 HMG-box domain SOXp PF12336.6 001171148.1_37922001_1 - 0.03 15.3 1.6 0.08 13.9 0.1 2.3 2 2 0 2 2 2 0 SOX transcription factor Globin PF00042.20 001171501.1_37921001_1 - 5.3e-25 88.0 0.0 8.5e-25 87.3 0.0 1.3 1 0 0 1 1 1 1 Globin Globin PF00042.20 001171502.1_37921001_1 - 8.8e-29 100.2 0.0 1.1e-28 99.8 0.0 1.1 1 0 0 1 1 1 1 Globin V1R PF03402.12 001167352.1_37922001_1 - 5.6e-27 94.9 15.4 6.9e-27 94.6 15.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167352.1_37922001_1 - 4.8e-13 48.7 16.3 6.2e-13 48.4 16.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167352.1_37922001_1 - 1.2e-06 27.9 14.2 1.5e-06 27.5 14.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) HemY_N PF07219.11 001167352.1_37922001_1 - 4.3 7.4 5.0 3.3 7.8 2.3 2.1 1 1 1 2 2 2 0 HemY protein N-terminus V1R PF03402.12 001167237.1_37922001_1 - 9.3e-65 218.7 25.1 1.1e-64 218.5 25.1 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R Lectin_C PF00059.19 001161885.1_39522001_1 - 2.4e-17 63.5 0.0 4.4e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 001161885.1_39522001_1 - 5.6e-09 35.5 30.1 2.7e-08 33.3 30.1 2.0 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) V1R PF03402.12 001167353.1_37922001_1 - 4e-30 105.2 16.3 5.7e-30 104.7 16.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167353.1_37922001_1 - 3.3e-12 46.0 17.8 4.1e-12 45.7 17.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167353.1_37922001_1 - 0.0035 16.5 16.3 0.0065 15.6 16.3 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167354.1_37922001_1 - 8e-31 107.5 9.8 1e-30 107.2 9.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167354.1_37922001_1 - 1.6e-09 37.2 9.8 2e-09 36.9 9.8 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167354.1_37922001_1 - 9.9e-08 31.4 8.6 2e-07 30.4 8.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zinc_ribbon_4 PF13717.4 001167354.1_37922001_3 - 0.071 12.9 0.6 4.6 7.1 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain V1R PF03402.12 001167355.1_37922001_1 - 1.5e-62 211.5 33.4 2e-62 211.1 33.4 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167355.1_37922001_1 - 0.003 16.7 25.9 0.004 16.3 25.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) tRNA_int_endo PF01974.15 001171495.1_37922001_1 - 1.2e-20 73.2 0.0 2.7e-20 72.1 0.0 1.6 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain V1R PF03402.12 001167357.1_37922001_1 - 8e-38 130.4 11.6 1.1e-37 130.0 11.6 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167357.1_37922001_1 - 4.9e-10 38.9 12.4 6.5e-10 38.5 12.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167357.1_37922001_1 - 9.1e-05 21.7 13.8 0.00013 21.2 13.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167242.1_37922001_1 - 4.6e-62 209.9 32.8 5.9e-62 209.6 32.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167242.1_37922001_1 - 2.1e-06 27.0 37.7 2.7e-06 26.6 37.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167242.1_37922001_1 - 0.0084 15.2 27.1 0.012 14.8 27.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167243.1_37922001_1 - 8.3e-29 100.9 22.1 1.1e-28 100.5 22.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167243.1_37922001_1 - 1.4e-08 34.1 19.2 1.6e-08 33.9 19.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167243.1_37922001_1 - 0.0019 17.3 16.1 0.0025 17.0 16.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167244.1_37922001_1 - 2.8e-37 128.7 16.4 3.6e-37 128.3 16.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167244.1_37922001_1 - 1e-07 31.3 13.2 1.4e-07 30.9 13.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167244.1_37922001_1 - 7.4e-07 28.4 18.6 8.8e-07 28.2 18.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Ninjurin PF04923.10 001167244.1_37922001_1 - 0.13 12.1 2.5 0.61 9.9 0.1 2.4 2 0 0 2 2 2 0 Ninjurin V1R PF03402.12 001167245.1_37922001_1 - 1.9e-67 227.6 28.4 2.3e-67 227.3 28.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167245.1_37922001_1 - 0.001 18.1 34.5 0.0012 17.9 34.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167245.1_37922001_1 - 0.075 12.1 26.3 0.094 11.8 25.6 1.5 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167246.1_37922001_1 - 1.4e-30 106.7 13.1 1.9e-30 106.3 13.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167246.1_37922001_1 - 1.9e-11 43.5 12.9 2.3e-11 43.2 12.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167246.1_37922001_1 - 2e-05 23.8 12.9 3.5e-05 23.1 12.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ndc1_Nup PF09531.8 001167246.1_37922001_1 - 0.33 9.5 5.6 0.55 8.7 5.6 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup V1R PF03402.12 001167358.1_37922001_1 - 2.4e-30 105.9 14.0 3.1e-30 105.6 14.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167358.1_37922001_1 - 4.2e-08 32.5 13.7 4.6e-08 32.4 13.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167358.1_37922001_1 - 7.5e-06 25.2 11.1 1e-05 24.8 11.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FA_desaturase PF00487.22 001167358.1_37922001_1 - 0.86 9.3 5.7 0.08 12.6 1.0 1.6 2 0 0 2 2 2 0 Fatty acid desaturase V1R PF03402.12 001167247.1_37922001_1 - 9.7e-30 103.9 12.9 1.2e-29 103.6 12.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167247.1_37922001_1 - 0.00015 21.0 10.4 0.00021 20.5 10.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FA_desaturase PF00487.22 001167247.1_37922001_1 - 0.27 10.9 5.0 0.036 13.8 0.8 1.7 2 0 0 2 2 2 0 Fatty acid desaturase IRK PF01007.18 001199109.1_37923001_1 - 9.6e-158 524.2 0.1 1.1e-157 524.0 0.1 1.0 1 0 0 1 1 1 1 Inward rectifier potassium channel IRK_N PF08466.8 001199109.1_37923001_1 - 1.4e-24 85.8 0.6 2.7e-24 84.9 0.6 1.5 1 0 0 1 1 1 1 Inward rectifier potassium channel N-terminal Ion_trans_2 PF07885.14 001199109.1_37923001_1 - 0.0069 16.2 4.1 0.02 14.7 4.1 1.8 1 1 0 1 1 1 1 Ion channel V1R PF03402.12 001167248.1_37922001_1 - 2.1e-33 115.9 18.1 2.9e-33 115.5 18.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167248.1_37922001_1 - 9.1e-11 41.3 20.8 1e-10 41.1 20.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167248.1_37922001_1 - 0.0096 15.1 16.3 0.018 14.2 16.3 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167249.1_37922001_1 - 1.2e-41 143.0 17.6 1.7e-41 142.5 17.6 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167249.1_37922001_1 - 7.6e-16 57.9 27.6 8.8e-16 57.7 27.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167249.1_37922001_1 - 2.9e-06 26.6 20.0 4.5e-06 26.0 20.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167373.1_32322001_1 - 2.1e-34 119.2 11.4 2.8e-34 118.8 11.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167373.1_32322001_1 - 5.8e-16 58.3 18.5 7e-16 58.1 18.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167373.1_32322001_1 - 0.091 11.8 17.9 0.2 10.7 17.9 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167250.1_37922001_1 - 3.4e-38 131.6 16.2 4e-38 131.4 16.2 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167250.1_37922001_1 - 1.2e-05 24.4 19.4 2.9e-05 23.2 19.4 1.5 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167250.1_37922001_1 - 0.00021 20.5 16.1 0.00037 19.7 16.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GP4 PF03010.12 001167250.1_37922001_1 - 0.0029 17.4 0.2 0.0067 16.2 0.1 1.7 2 0 0 2 2 2 1 GP4 V1R PF03402.12 001167374.1_32322001_1 - 1.7e-32 113.0 12.5 2.3e-32 112.5 12.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167374.1_32322001_1 - 8.5e-15 54.5 19.9 1e-14 54.2 19.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167374.1_32322001_1 - 0.00033 19.8 15.5 0.00052 19.2 15.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167361.1_37922001_1 - 1.6e-32 113.0 16.7 1.9e-32 112.8 16.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167361.1_37922001_1 - 1.5e-18 66.9 18.9 1.7e-18 66.7 18.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167361.1_37922001_1 - 5.3e-05 22.5 16.1 7.6e-05 21.9 16.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167375.1_32322001_1 - 9.1e-35 120.4 9.5 1.2e-34 120.0 9.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167375.1_32322001_1 - 1.5e-16 60.2 18.3 1.9e-16 60.0 18.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167375.1_32322001_1 - 0.0036 16.4 14.9 0.0056 15.8 14.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167251.1_37922001_1 - 8.9e-37 127.0 15.6 1e-36 126.8 15.6 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167251.1_37922001_1 - 1.4e-05 24.2 18.9 2.3e-05 23.5 18.9 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167251.1_37922001_1 - 7.5e-05 22.0 16.3 0.00014 21.0 16.3 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167376.1_32322001_1 - 8e-34 117.3 9.8 1.1e-33 116.9 9.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167376.1_32322001_1 - 7.5e-15 54.7 17.3 9e-15 54.4 17.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167376.1_32322001_1 - 0.0016 17.6 14.2 0.0026 16.9 14.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167252.1_37922001_1 - 8.8e-39 133.6 16.9 1e-38 133.3 16.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167252.1_37922001_1 - 0.00018 20.6 20.3 0.00025 20.1 20.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167252.1_37922001_1 - 0.00067 18.8 18.7 0.0011 18.1 18.7 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GP4 PF03010.12 001167252.1_37922001_1 - 0.016 15.0 0.2 0.04 13.7 0.1 1.7 2 0 0 2 2 2 0 GP4 V1R PF03402.12 001167490.1_32322001_1 - 7.1e-19 68.3 28.1 9.9e-19 67.8 28.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167490.1_32322001_1 - 1.1e-08 34.5 44.2 1.2e-08 34.3 44.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167490.1_32322001_1 - 1.8e-06 27.3 29.2 2.3e-06 26.9 29.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167253.1_37922001_1 - 2.1e-59 201.2 27.7 2.6e-59 200.9 27.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167253.1_37922001_1 - 8.3e-06 25.0 30.7 1.6e-05 24.1 30.7 1.6 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) TctB PF07331.9 001167253.1_37922001_1 - 0.21 11.7 12.5 0.1 12.7 8.2 2.5 1 1 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family Abhydrolase_9_N PF15420.4 001167253.1_37922001_1 - 3 7.6 7.7 5.1 6.9 4.6 2.3 1 1 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus V1R PF03402.12 001167491.1_32322001_1 - 4.8e-34 118.1 12.4 6.7e-34 117.6 12.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167491.1_32322001_1 - 1.9e-14 53.3 19.4 2.3e-14 53.1 19.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167491.1_32322001_1 - 0.00045 19.4 14.8 0.00071 18.8 14.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167492.1_32322001_1 - 2.4e-34 119.0 8.9 3.4e-34 118.6 8.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167492.1_32322001_1 - 2.2e-15 56.4 16.8 2.6e-15 56.2 16.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167492.1_32322001_1 - 0.015 14.4 14.6 0.022 13.9 14.6 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167493.1_32322001_1 - 7.3e-35 120.7 8.9 1e-34 120.3 8.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167493.1_32322001_1 - 3.1e-15 55.9 16.4 3.7e-15 55.7 16.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167493.1_32322001_1 - 0.068 12.3 16.7 0.13 11.3 16.7 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167494.1_32322001_1 - 1.7e-33 116.3 9.0 2.3e-33 115.8 9.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167494.1_32322001_1 - 1.7e-14 53.5 16.5 2e-14 53.3 16.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167494.1_32322001_1 - 0.00099 18.3 13.4 0.0017 17.6 13.4 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167254.1_37922001_1 - 1.5e-37 129.6 16.8 1.9e-37 129.2 16.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167254.1_37922001_1 - 2.5e-11 43.1 25.3 3.2e-11 42.8 25.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167254.1_37922001_1 - 0.00035 19.8 17.3 0.00049 19.3 17.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167495.1_32322001_1 - 1.1e-32 113.6 12.7 1.4e-32 113.2 12.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167495.1_32322001_1 - 2.1e-15 56.5 19.9 2.5e-15 56.3 19.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167495.1_32322001_1 - 0.0031 16.7 16.6 0.0049 16.0 16.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167496.1_32322001_1 - 3e-26 92.5 18.6 4.2e-26 92.0 18.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167496.1_32322001_1 - 2.4e-12 46.5 30.5 3.1e-12 46.1 30.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF2254 PF10011.7 001167496.1_32322001_1 - 0.0065 15.2 1.1 0.01 14.6 1.1 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2254) TMEM132D_C PF15706.3 001167496.1_32322001_1 - 0.082 12.6 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term V1R PF03402.12 001167255.1_37922001_1 - 2.5e-29 102.6 17.5 3.5e-29 102.1 17.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167255.1_37922001_1 - 7.7e-13 48.1 18.1 9.2e-13 47.8 18.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167255.1_37922001_1 - 0.0036 16.4 16.2 0.0071 15.5 16.2 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167497.1_32322001_1 - 1.1e-34 120.1 15.1 1.5e-34 119.7 15.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167497.1_32322001_1 - 1.8e-10 40.3 23.2 2.4e-10 39.9 23.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167498.1_32322001_1 - 1.1e-29 103.8 14.7 1.8e-29 103.1 14.7 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167498.1_32322001_1 - 1.9e-05 23.8 22.2 2.4e-05 23.5 22.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167498.1_32322001_1 - 0.0002 20.6 18.7 0.0002 20.6 18.7 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167256.1_37922001_1 - 2e-29 102.9 13.0 2.5e-29 102.6 13.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167256.1_37922001_1 - 2.8e-10 39.6 13.6 3.7e-10 39.3 13.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167256.1_37922001_1 - 1.8e-08 33.8 12.9 2.3e-08 33.5 12.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167499.1_32322001_1 - 1.9e-32 112.8 10.4 3.2e-32 112.1 10.4 1.3 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167499.1_32322001_1 - 1.5e-08 34.0 18.6 1.7e-08 33.8 18.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167499.1_32322001_1 - 3e-05 23.3 17.2 6.1e-05 22.2 17.2 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167500.1_32322001_1 - 1.4e-24 87.0 22.6 2.1e-24 86.4 22.6 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167500.1_32322001_1 - 5.5e-07 28.9 38.6 6.6e-07 28.6 38.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167257.1_37922001_1 - 1.1e-28 100.5 19.2 1.5e-28 100.0 19.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167257.1_37922001_1 - 2.2e-10 40.0 20.5 2.7e-10 39.7 20.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167257.1_37922001_1 - 0.00079 18.6 17.2 0.0013 17.9 17.2 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Nucleoplasmin PF03066.13 001171319.1_37922001_1 - 2.1e-47 159.7 0.0 3.9e-47 158.8 0.0 1.5 1 0 0 1 1 1 1 Nucleoplasmin/nucleophosmin domain NPM1-C PF16276.3 001171319.1_37922001_1 - 4.1e-34 116.1 0.9 4.1e-34 116.1 0.9 2.0 2 0 0 2 2 2 1 Nucleophosmin C-terminal domain SDA1 PF05285.10 001171319.1_37922001_1 - 0.0011 18.4 14.1 0.0015 18.0 14.1 1.2 1 0 0 1 1 1 1 SDA1 TFIIF_alpha PF05793.10 001171319.1_37922001_1 - 0.0069 14.9 24.9 0.0094 14.5 24.9 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.10 001171319.1_37922001_1 - 0.0096 14.1 19.0 0.014 13.6 19.0 1.1 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.12 001171319.1_37922001_1 - 0.12 10.6 15.1 0.16 10.1 15.1 1.2 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.10 001171319.1_37922001_1 - 0.14 11.4 16.7 0.27 10.4 16.7 1.5 1 0 0 1 1 1 0 NOA36 protein SAPS PF04499.13 001171319.1_37922001_1 - 0.5 8.9 7.0 0.62 8.6 7.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DNA_pol_phi PF04931.11 001171319.1_37922001_1 - 0.91 7.4 23.4 1.3 6.9 23.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi GCIP PF13324.4 001171319.1_37922001_1 - 1.6 8.2 8.0 2.7 7.4 8.0 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Hid1 PF12722.5 001171319.1_37922001_1 - 3.9 5.3 6.4 4.8 5.0 6.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein V1R PF03402.12 001167501.1_32322001_1 - 3.5e-34 118.5 20.0 4.4e-34 118.2 20.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167501.1_32322001_1 - 5.9e-12 45.2 31.5 7.2e-12 44.9 31.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167501.1_32322001_1 - 0.00032 19.9 25.3 0.00042 19.5 25.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167502.1_32322001_1 - 5.6e-28 98.2 15.6 6.7e-28 97.9 15.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167502.1_32322001_1 - 2.5e-08 33.3 25.0 3e-08 33.0 25.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167502.1_32322001_1 - 0.0026 16.9 16.9 0.004 16.3 16.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167503.1_32322001_1 - 7.3e-30 104.3 12.7 9.2e-30 104.0 12.7 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167503.1_32322001_1 - 6.1e-10 38.6 21.0 7.4e-10 38.3 21.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF4133 PF13571.4 001167503.1_32322001_1 - 0.0055 16.9 0.4 1.4 9.1 0.0 2.9 2 0 0 2 2 2 2 Domain of unknown function (DUF4133) V1R PF03402.12 001167504.1_32323001_1 - 3.8e-28 98.7 23.1 5.1e-28 98.3 23.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167504.1_32323001_1 - 4e-09 35.9 29.8 5.4e-09 35.4 29.8 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167504.1_32323001_1 - 0.0071 15.5 15.9 0.011 14.9 15.9 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167505.1_32322001_1 - 1.9e-29 103.0 13.5 2.4e-29 102.6 13.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167505.1_32322001_1 - 1.5e-13 50.4 21.5 1.8e-13 50.2 21.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167505.1_32322001_1 - 0.00076 18.7 14.5 0.0011 18.1 14.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167506.1_32322001_1 - 2.5e-31 109.1 15.0 3e-31 108.9 15.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167506.1_32322001_1 - 1.4e-09 37.4 17.5 1.5e-09 37.2 17.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) BRI3BP PF14965.4 001167506.1_32322001_1 - 0.0014 18.0 0.4 0.0032 16.9 0.4 1.7 1 0 0 1 1 1 1 Negative regulator of p53/TP53 MIEAP PF16026.3 001167506.1_32322001_1 - 0.14 12.1 0.1 0.21 11.6 0.1 1.3 1 0 0 1 1 1 0 Mitochondria-eating protein V1R PF03402.12 001167261.1_37922001_1 - 8e-36 123.9 18.8 1.1e-35 123.4 18.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167261.1_37922001_1 - 1.8e-11 43.6 32.2 2.1e-11 43.3 32.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167261.1_37922001_1 - 0.0054 15.9 17.2 0.008 15.3 17.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167508.1_32322001_1 - 4.3e-30 105.1 18.1 4.3e-30 105.1 18.1 1.5 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167508.1_32322001_1 - 1e-10 41.1 22.7 1.1e-10 41.0 22.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167508.1_32322001_1 - 4.5e-07 29.2 13.8 5.5e-07 28.9 13.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ETRAMP PF09716.8 001167508.1_32322001_1 - 0.08 12.9 1.9 12 5.9 0.0 2.7 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) V1R PF03402.12 001167510.1_32322001_1 - 5.6e-33 114.6 19.5 7.8e-33 114.1 19.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167510.1_32322001_1 - 3.1e-06 26.5 24.7 3.1e-06 26.5 24.7 1.5 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167510.1_32322001_1 - 5.4e-06 25.6 25.5 5.4e-06 25.6 25.5 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) DAP3 PF10236.7 001167510.1_32322001_1 - 0.091 11.8 0.1 0.13 11.2 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 V1R PF03402.12 001167511.1_32322001_1 - 2.6e-27 96.0 20.7 3.6e-27 95.5 20.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167511.1_32322001_1 - 1.5e-08 33.9 33.7 1.8e-08 33.8 33.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TctB PF07331.9 001167511.1_32322001_1 - 0.008 16.3 16.9 2.5 8.2 3.3 3.2 3 0 0 3 3 3 3 Tripartite tricarboxylate transporter TctB family V1R PF03402.12 001167263.1_37922001_1 - 1.7e-27 96.6 10.8 2.2e-27 96.2 10.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167263.1_37922001_1 - 4.8e-10 38.9 9.5 5.3e-10 38.8 9.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167263.1_37922001_1 - 4.6e-05 22.6 8.2 6.5e-05 22.2 8.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167512.1_32322001_1 - 2.5e-30 105.9 12.2 3e-30 105.6 12.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167512.1_32322001_1 - 4.8e-15 55.3 21.6 5.3e-15 55.2 21.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF4234 PF14018.4 001167512.1_32322001_1 - 0.0051 16.8 0.8 0.0051 16.8 0.8 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4234) V1R PF03402.12 001167513.1_32322001_1 - 1.4e-33 116.6 19.2 1.8e-33 116.2 19.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167513.1_32322001_1 - 1.2e-07 31.0 28.5 1.6e-07 30.6 28.5 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF2976 PF11190.6 001167513.1_32322001_1 - 0.061 13.0 3.1 0.11 12.1 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) V1R PF03402.12 001167269.1_37922001_1 - 4.5e-31 108.3 11.5 5.9e-31 107.9 11.5 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167269.1_37922001_1 - 1.4e-11 44.0 10.6 1.6e-11 43.7 10.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167269.1_37922001_1 - 6.6e-09 35.3 12.3 8.3e-09 34.9 12.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MMPL PF03176.13 001167269.1_37922001_1 - 0.011 14.5 0.9 0.019 13.8 0.2 1.7 2 0 0 2 2 2 0 MMPL family 7TM_GPCR_Srd PF10317.7 001167269.1_37922001_1 - 0.23 10.5 15.4 0.7 8.9 15.4 2.0 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srd TMEM138 PF14935.4 001167269.1_37922001_1 - 2.7 8.5 10.2 0.073 13.6 2.0 2.2 2 0 0 2 2 2 0 Transmembrane protein 138 V1R PF03402.12 001167271.1_37922001_1 - 1.5e-61 208.3 24.6 1.8e-61 207.9 24.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167271.1_37922001_1 - 0.0072 15.3 28.7 0.014 14.4 28.7 1.9 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) Interferon PF00143.17 001242709.1_37622001_1 - 2.8e-53 180.2 0.2 3.5e-53 179.9 0.2 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain V1R PF03402.12 001167521.1_32322001_1 - 6.5e-33 114.3 17.3 8.8e-33 113.9 17.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167521.1_32322001_1 - 9.6e-17 60.9 27.4 1.1e-16 60.7 27.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167521.1_32322001_1 - 1.9e-05 23.9 20.9 2.6e-05 23.5 20.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ABC2_membrane_2 PF12679.5 001167521.1_32322001_1 - 0.024 13.8 1.6 0.049 12.8 1.6 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein V1R PF03402.12 001167523.1_32322001_1 - 1.4e-31 109.9 23.6 1.9e-31 109.5 23.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167523.1_32322001_1 - 6.9e-16 58.1 33.2 8.3e-16 57.8 33.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167523.1_32322001_1 - 0.00018 20.7 25.7 0.00018 20.7 25.7 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Interferon PF00143.17 001242710.1_37622001_1 - 2.4e-53 180.4 0.2 3.1e-53 180.1 0.2 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain Interferon PF00143.17 001242711.1_37622001_1 - 5.2e-52 176.1 0.7 6.2e-52 175.9 0.7 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain DUF4164 PF13747.4 001242711.1_37622001_1 - 0.099 12.8 0.3 2.8 8.1 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) V1R PF03402.12 001167283.1_37922001_1 - 1.3e-50 172.4 26.7 1.5e-50 172.1 26.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167283.1_37922001_1 - 3.4e-05 23.0 30.0 4.2e-05 22.7 30.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Interferon PF00143.17 001242718.1_37622001_1 - 8.4e-57 191.7 4.1 9.6e-57 191.5 4.1 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain MIEAP PF16026.3 001242718.1_37622001_1 - 0.027 14.5 0.1 0.031 14.3 0.1 1.1 1 0 0 1 1 1 0 Mitochondria-eating protein V1R PF03402.12 001167296.1_37922001_1 - 6.4e-35 120.9 9.4 1e-34 120.3 9.4 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167296.1_37922001_1 - 1.8e-10 40.3 13.2 2.1e-10 40.1 13.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167298.1_37922001_1 - 8.3e-34 117.3 14.7 1.2e-33 116.7 14.7 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167298.1_37922001_1 - 2.3e-09 36.7 12.6 2.7e-09 36.4 12.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167298.1_37922001_1 - 5.7e-08 32.2 10.8 7.7e-08 31.7 10.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167299.1_37922001_1 - 4e-24 85.5 13.0 5e-24 85.2 13.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167299.1_37922001_1 - 2.9e-14 52.7 13.6 3.4e-14 52.5 13.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167299.1_37922001_1 - 2.6e-05 23.5 16.1 4.4e-05 22.7 15.9 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FA_desaturase PF00487.22 001167299.1_37922001_1 - 0.42 10.3 8.0 0.36 10.5 2.7 2.2 2 0 0 2 2 2 0 Fatty acid desaturase DUF1816 PF08846.8 001167299.1_37922001_3 - 0.096 12.6 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1816) V1R PF03402.12 001167304.1_37922001_1 - 3.8e-32 111.8 13.4 5.2e-32 111.4 13.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167304.1_37922001_1 - 9e-07 28.2 12.7 1.6e-06 27.3 12.7 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167304.1_37922001_1 - 1.4e-06 27.6 12.7 2.1e-06 27.1 12.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.19 001205051.1_32324001_1 - 3.3e-18 65.7 9.6 5.5e-18 65.0 9.6 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Glyco_hydro_11 PF00457.15 001159504.1_39522001_1 - 3.5e-36 124.4 18.4 5.6e-36 123.7 18.4 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 11 ArAE_1 PF06081.9 001159504.1_39522001_2 - 0.038 14.0 1.1 0.056 13.5 1.1 1.2 1 0 0 1 1 1 0 Aromatic acid exporter family member 1 V1R PF03402.12 001167327.1_37922001_1 - 6.1e-29 101.3 12.0 7.4e-29 101.0 12.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167327.1_37922001_1 - 4.3e-11 42.3 16.3 5.1e-11 42.1 16.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) AA_permease_2 PF13520.4 001167327.1_37922001_1 - 0.00026 19.8 6.0 0.00036 19.4 6.0 1.4 1 1 0 1 1 1 1 Amino acid permease 7tm_1 PF00001.19 001167327.1_37922001_1 - 0.00053 19.2 12.0 0.00076 18.7 12.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SDP_N PF12278.6 001167327.1_37922001_1 - 0.016 14.8 0.0 2.9 7.4 0.0 2.1 2 0 0 2 2 2 0 Sex determination protein N terminal GAGA PF09237.9 001167327.1_37922001_1 - 0.055 13.2 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 GAGA factor EXS PF03124.12 001167327.1_37922001_1 - 0.13 11.4 11.7 0.026 13.7 7.5 1.8 2 0 0 2 2 2 0 EXS family PRA1 PF03208.17 001167327.1_37922001_1 - 9 5.8 12.1 0.68 9.4 6.3 2.1 2 1 0 2 2 2 0 PRA1 family protein V1R PF03402.12 001166802.1_32322001_1 - 5.2e-33 114.7 10.3 7.2e-33 114.2 10.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166802.1_32322001_1 - 1.7e-14 53.5 16.8 2e-14 53.3 16.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166802.1_32322001_1 - 0.044 12.9 17.6 0.11 11.6 17.6 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167337.1_37922001_1 - 7.7e-43 146.9 18.3 1.1e-42 146.4 18.3 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167337.1_37922001_1 - 1.1e-14 54.2 29.4 1.2e-14 54.0 29.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167337.1_37922001_1 - 7.4e-07 28.5 19.6 1.1e-06 28.0 19.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) UCR_TM PF02921.12 001167337.1_37922001_1 - 0.05 13.9 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 Ubiquinol cytochrome reductase transmembrane region 7TM_GPCR_Srv PF10323.7 001167337.1_37922001_1 - 0.091 12.0 24.0 0.016 14.4 19.4 1.8 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv TMEM132D_C PF15706.3 001167337.1_37922001_1 - 0.11 12.1 0.0 0.27 10.9 0.0 1.7 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term TRAM1 PF08390.9 001167337.1_37922001_1 - 8.6 6.0 12.4 0.061 12.8 1.5 2.9 3 0 0 3 3 3 0 TRAM1-like protein V1R PF03402.12 001167343.1_37922001_1 - 2.8e-66 223.7 26.5 3.3e-66 223.5 26.5 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167343.1_37922001_1 - 5.1e-06 25.7 31.1 6.6e-06 25.3 31.1 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF1129 PF06570.9 001167343.1_37922001_1 - 4.1 6.7 8.3 1.2 8.5 4.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) V1R PF03402.12 001167344.1_37922001_1 - 1.2e-30 106.9 17.7 1.6e-30 106.5 17.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167344.1_37922001_1 - 1.5e-13 50.4 17.4 1.7e-13 50.2 17.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167344.1_37922001_1 - 0.00035 19.8 16.0 0.00059 19.0 16.0 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001166828.1_32323001_1 - 4.1e-34 118.3 16.2 5.4e-34 117.9 16.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166828.1_32323001_1 - 8.5e-14 51.2 19.2 1e-13 50.9 19.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001166834.1_32322001_1 - 7.1e-33 114.2 11.5 9.7e-33 113.8 11.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166834.1_32322001_1 - 6.4e-15 54.9 18.3 7.7e-15 54.6 18.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166834.1_32322001_1 - 0.0053 15.9 18.1 0.01 15.0 18.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167191.1_37922001_1 - 2.3e-29 102.7 13.5 3e-29 102.3 13.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167191.1_37922001_1 - 3.9e-07 29.3 13.3 4.6e-07 29.1 13.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167191.1_37922001_1 - 0.00085 18.5 10.8 0.0012 18.1 10.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FA_desaturase PF00487.22 001167191.1_37922001_1 - 1.2 8.7 5.9 0.13 11.9 1.5 1.6 2 0 0 2 2 2 0 Fatty acid desaturase V1R PF03402.12 001167193.1_37922001_1 - 3.4e-29 102.1 11.7 4.4e-29 101.8 11.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167193.1_37922001_1 - 6.4e-09 35.2 11.7 7.2e-09 35.0 11.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167193.1_37922001_1 - 3.7e-06 26.2 9.0 5.2e-06 25.7 9.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167348.1_37923001_1 - 4.9e-101 337.7 23.5 6e-101 337.4 23.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167348.1_37923001_1 - 0.39 9.8 25.2 0.25 10.4 23.1 1.7 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001171438.1_37922001_1 - 3.5e-118 394.2 21.5 4.1e-118 394.0 21.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171438.1_37922001_1 - 1.4e-16 60.4 20.2 4.6e-16 58.7 20.2 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171438.1_37922001_1 - 4.2e-08 32.8 15.3 7.7e-08 31.9 15.3 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF3693 PF12472.6 001171438.1_37922001_1 - 0.17 11.5 0.1 0.39 10.3 0.1 1.6 1 0 0 1 1 1 0 Phage related protein YrhC PF14143.4 001171438.1_37922001_1 - 0.24 11.4 3.1 0.18 11.8 0.5 2.1 2 0 0 2 2 2 0 YrhC-like protein 7tm_4 PF13853.4 001171440.1_37922001_1 - 1.1e-109 366.3 24.1 1.3e-109 366.1 24.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171440.1_37922001_1 - 1.1e-16 60.7 21.4 2.5e-16 59.6 21.4 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171440.1_37922001_1 - 0.0001 21.6 17.8 0.0002 20.7 17.8 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1129 PF06570.9 001171440.1_37922001_1 - 0.23 10.8 1.4 0.48 9.8 1.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Amidase_2 PF01510.23 001244361.1_49824001_3 - 2.8e-30 105.2 0.0 3.6e-16 59.6 0.1 2.2 2 0 0 2 2 2 2 N-acetylmuramoyl-L-alanine amidase V1R PF03402.12 001167203.1_37922001_1 - 2.6e-29 102.5 12.7 3.7e-29 102.0 12.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167203.1_37922001_1 - 1.3e-09 37.5 13.4 1.4e-09 37.4 13.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167203.1_37922001_1 - 1.2e-05 24.6 10.4 2.1e-05 23.8 10.4 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167207.1_37922001_1 - 3.4e-41 141.5 19.3 4.4e-41 141.1 19.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167207.1_37922001_1 - 5e-14 52.0 29.8 5.6e-14 51.8 29.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167207.1_37922001_1 - 2.3e-06 26.9 19.2 3.4e-06 26.4 19.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001167207.1_37922001_1 - 0.087 12.0 24.3 0.2 10.8 24.4 1.6 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv UCR_TM PF02921.12 001167207.1_37922001_1 - 0.15 12.4 0.0 0.36 11.2 0.0 1.6 1 0 0 1 1 1 0 Ubiquinol cytochrome reductase transmembrane region 7tm_4 PF13853.4 001171454.1_37922001_1 - 2.7e-113 378.2 20.1 3.2e-113 378.0 20.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171454.1_37922001_1 - 1.4e-18 66.9 16.9 5.5e-18 65.0 16.9 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171454.1_37922001_1 - 6.2e-09 35.5 12.9 3.1e-08 33.2 12.9 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx V1R PF03402.12 001167210.1_37922001_1 - 2.4e-33 115.8 15.4 3.3e-33 115.3 15.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167210.1_37922001_1 - 0.0013 17.9 15.8 0.0018 17.4 15.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.19 001171124.1_37923001_1 - 2.5e-51 174.3 21.8 5.2e-51 173.3 21.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171124.1_37923001_1 - 8.1e-09 35.1 19.8 1e-08 34.8 19.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001171124.1_37923001_1 - 0.032 13.4 15.5 0.1 11.8 15.5 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF1240 PF06836.10 001171124.1_37923001_1 - 3.1 8.2 12.2 0.62 10.4 0.4 3.1 2 2 1 3 3 3 0 Protein of unknown function (DUF1240) V1R PF03402.12 001167216.1_37922001_1 - 5.4e-30 104.8 12.0 7.1e-30 104.4 12.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167216.1_37922001_1 - 7.9e-09 34.9 11.8 8.6e-09 34.8 11.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167216.1_37922001_1 - 0.00011 21.4 9.7 0.00016 20.9 9.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167218.1_37922001_1 - 7.6e-62 209.2 34.0 9.9e-62 208.8 34.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167218.1_37922001_1 - 5.9e-05 22.2 37.9 7.9e-05 21.8 37.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_4 PF13853.4 001171471.1_37923001_1 - 2.1e-108 362.2 17.6 2.5e-108 361.9 17.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171471.1_37923001_1 - 5.3e-23 81.5 20.3 1.2e-22 80.3 20.3 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171471.1_37923001_1 - 2.8e-11 43.2 13.5 4.6e-11 42.4 13.5 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171474.1_37922001_1 - 3.1e-103 345.2 22.0 3.6e-103 345.0 22.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001171474.1_37922001_1 - 6.7e-18 64.7 25.7 2.7e-17 62.7 25.7 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171474.1_37922001_1 - 1.5e-07 31.0 19.6 2.1e-07 30.5 19.6 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx V1R PF03402.12 001167350.1_37922001_1 - 7.5e-38 130.5 17.2 9.2e-38 130.2 17.2 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167350.1_37922001_1 - 9.2e-10 38.0 22.2 1.2e-09 37.6 22.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167350.1_37922001_1 - 0.0001 21.5 16.5 0.00014 21.0 16.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-DHHC PF01529.18 001167350.1_37922001_1 - 0.0039 17.2 3.4 0.0039 17.2 3.4 2.7 2 1 0 2 2 2 1 DHHC palmitoyltransferase V1R PF03402.12 001167234.1_37922001_1 - 1.6e-35 122.9 18.5 2.1e-35 122.5 18.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167234.1_37922001_1 - 2.2e-08 33.6 15.4 3e-08 33.1 15.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167234.1_37922001_1 - 4.1e-07 29.3 18.7 5.2e-07 28.9 18.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Ninjurin PF04923.10 001167234.1_37922001_1 - 0.11 12.3 1.7 1 9.2 0.1 2.5 2 0 0 2 2 2 0 Ninjurin V1R PF03402.12 001167351.1_37922001_1 - 5.1e-66 222.9 25.5 6.2e-66 222.6 25.5 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167351.1_37922001_1 - 0.00011 21.4 29.9 0.00015 20.8 29.9 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF1211 PF06736.9 001167351.1_37922001_1 - 2.1 8.7 11.6 0.45 10.9 3.4 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1211) V1R PF03402.12 001167239.1_37922001_1 - 3.4e-65 220.2 29.4 4.6e-65 219.7 29.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167239.1_37922001_1 - 1.4e-05 24.3 32.9 1.8e-05 23.9 32.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167359.1_37922001_1 - 5.2e-40 137.6 13.8 6.8e-40 137.2 13.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167359.1_37922001_1 - 1.1e-13 50.8 18.9 1.3e-13 50.6 18.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167359.1_37922001_1 - 2.9e-06 26.6 13.9 4.5e-06 26.0 13.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2189 PF09955.7 001167359.1_37922001_1 - 0.063 13.4 0.0 0.063 13.4 0.0 2.5 2 1 0 3 3 3 0 Predicted integral membrane protein (DUF2189) AIM5 PF17050.3 001167359.1_37922001_1 - 0.14 12.3 0.2 5.6 7.2 0.0 2.4 2 0 0 2 2 2 0 Altered inheritance of mitochondria 5 V1R PF03402.12 001167260.1_37922001_1 - 8.1e-27 94.4 11.2 1e-26 94.0 11.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167260.1_37922001_1 - 7.8e-10 38.2 9.8 8.7e-10 38.1 9.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167260.1_37922001_1 - 2.6e-05 23.4 8.2 3.8e-05 22.9 8.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167507.1_32322001_1 - 2.6e-23 82.9 21.9 4.5e-23 82.1 21.9 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167507.1_32322001_1 - 5.1e-10 38.8 29.5 6.5e-10 38.5 29.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167507.1_32322001_1 - 1.1 8.3 23.1 2.5 7.1 23.1 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167509.1_32322001_1 - 1.5e-24 86.9 21.6 8.2e-24 84.5 21.6 1.9 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167509.1_32322001_1 - 4.3e-12 45.6 30.4 4.9e-12 45.4 30.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TarH PF02203.13 001167509.1_32322001_1 - 0.18 11.6 0.7 0.31 10.8 0.0 1.7 2 0 0 2 2 2 0 Tar ligand binding domain homologue TctB PF07331.9 001167509.1_32322001_1 - 0.98 9.6 20.2 2 8.6 2.3 3.4 3 0 0 3 3 3 0 Tripartite tricarboxylate transporter TctB family V1R PF03402.12 001167262.1_37922001_1 - 8.8e-24 84.4 14.7 1.1e-23 84.1 14.7 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167262.1_37922001_1 - 5.7e-10 38.7 18.7 6.9e-10 38.4 18.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167262.1_37922001_1 - 0.00093 18.4 15.8 0.0015 17.7 15.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ninjurin PF04923.10 001167262.1_37922001_1 - 0.059 13.2 0.8 0.15 11.9 0.3 1.9 1 1 1 2 2 2 0 Ninjurin V1R PF03402.12 001253576.1_37622001_1 - 1.5e-34 119.7 15.0 2e-34 119.3 15.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253576.1_37622001_1 - 3.6e-06 26.2 21.0 4.4e-06 25.9 21.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253580.1_37622001_1 - 4.6e-25 88.6 13.4 5.4e-25 88.4 13.4 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R Abhydrolase_9_N PF15420.4 001253580.1_37622001_1 - 0.037 13.9 0.2 1.2 9.0 0.1 2.1 1 1 1 2 2 2 0 Alpha/beta-hydrolase family N-terminus 7tm_1 PF00001.19 001253580.1_37622001_1 - 0.41 9.7 12.8 1.2 8.2 12.8 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253586.1_37622001_1 - 8.6e-38 130.3 18.9 1.2e-37 129.9 18.9 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253586.1_37622001_1 - 4e-11 42.5 24.9 4.8e-11 42.2 24.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253601.1_37622001_1 - 4.2e-37 128.1 18.0 5.8e-37 127.6 18.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253601.1_37622001_1 - 6e-10 38.6 21.6 7.3e-10 38.3 21.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253611.1_37622001_1 - 1.2e-33 116.8 10.1 1.4e-33 116.5 10.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253611.1_37622001_1 - 4.4e-14 52.1 11.9 5.3e-14 51.9 11.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253611.1_37622001_1 - 0.57 9.2 12.0 1.4 7.9 11.6 1.8 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253615.1_37622001_1 - 4.8e-34 118.1 7.5 6.1e-34 117.7 7.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253615.1_37622001_1 - 7.2e-17 61.3 5.2 9.8e-17 60.9 5.2 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253615.1_37622001_1 - 0.0036 16.4 2.9 0.0036 16.4 2.9 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4271 PF14093.4 001253615.1_37622001_1 - 0.062 13.1 7.8 0.41 10.4 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) V1R PF03402.12 001253623.1_37622001_1 - 4.8e-45 154.1 16.1 5.7e-45 153.9 16.1 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253623.1_37622001_1 - 9.9e-10 37.9 16.4 1.3e-09 37.5 16.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253623.1_37622001_1 - 0.0053 15.9 17.1 0.0058 15.8 14.7 1.8 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253624.1_37622001_1 - 4.5e-45 154.2 15.2 6.1e-45 153.8 15.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253624.1_37622001_1 - 7.5e-11 41.5 13.9 9.5e-11 41.2 13.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253624.1_37622001_1 - 0.017 14.3 17.6 0.02 14.0 17.2 1.3 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253642.1_37622001_1 - 9.6e-51 172.8 14.0 1.3e-50 172.4 14.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253642.1_37622001_1 - 4.7e-15 55.3 15.3 5.7e-15 55.1 15.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253642.1_37622001_1 - 0.0016 17.6 21.7 0.0035 16.5 21.7 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253396.1_37622001_1 - 1e-40 139.9 10.9 1.3e-40 139.6 10.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253396.1_37622001_1 - 4.3e-08 32.5 7.6 6.6e-08 31.9 7.6 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MMPL PF03176.13 001253396.1_37622001_1 - 0.015 14.1 0.3 0.015 14.1 0.3 2.0 3 0 0 3 3 3 0 MMPL family LELP1 PF15042.4 001253396.1_37622001_3 - 0.061 13.7 0.8 0.061 13.7 0.8 2.3 2 0 0 2 2 2 0 Late cornified envelope-like proline-rich protein 1 V1R PF03402.12 001253402.1_37622001_1 - 4.2e-32 111.7 9.1 5.7e-32 111.2 9.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253402.1_37622001_1 - 2.1e-14 53.2 7.2 2.9e-14 52.7 7.2 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253402.1_37622001_1 - 0.00099 18.3 2.9 0.0017 17.5 2.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Epiglycanin_C PF14654.4 001253402.1_37622001_1 - 0.1 12.5 1.3 5.6 7.0 0.2 2.6 2 0 0 2 2 2 0 Mucin, catalytic, TM and cytoplasmic tail region MMPL PF03176.13 001253402.1_37622001_1 - 0.25 10.1 3.1 2.9 6.6 0.2 2.3 2 0 0 2 2 2 0 MMPL family V1R PF03402.12 001253403.1_37622001_1 - 5.9e-34 117.8 12.2 7.5e-34 117.4 12.2 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253403.1_37622001_1 - 1.1e-14 54.1 11.1 1.5e-14 53.7 11.1 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253403.1_37622001_1 - 9.4e-05 21.6 4.4 9.7e-05 21.6 3.6 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253404.1_37622001_1 - 1.2e-34 120.0 10.5 1.2e-34 120.0 10.5 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253404.1_37622001_1 - 7.6e-11 41.5 13.8 1e-10 41.1 13.8 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253405.1_37622001_1 - 4.6e-42 144.3 11.0 6.1e-42 143.9 11.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253405.1_37622001_1 - 9e-12 44.6 13.0 1.1e-11 44.3 13.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253405.1_37622001_1 - 0.00018 20.7 10.4 0.00024 20.3 10.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253410.1_37622001_1 - 2.1e-31 109.4 6.9 2.9e-31 108.9 6.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253410.1_37622001_1 - 1e-09 37.8 8.2 1.3e-09 37.5 8.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253410.1_37622001_1 - 0.0016 17.6 6.3 0.0022 17.2 6.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253412.1_37622001_1 - 7.6e-38 130.5 9.6 1e-37 130.1 9.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253412.1_37622001_1 - 5.6e-11 42.0 9.9 7.3e-11 41.6 9.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253412.1_37622001_1 - 5.3 6.0 9.5 10 5.1 9.5 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253667.1_37622001_1 - 1.7e-41 142.4 15.7 2.3e-41 142.0 15.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253667.1_37622001_1 - 5.2e-13 48.6 18.3 6.5e-13 48.3 18.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253414.1_37622001_1 - 1.4e-42 146.0 17.7 1.9e-42 145.6 17.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253414.1_37622001_1 - 1.8e-11 43.6 21.4 2.2e-11 43.3 21.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253414.1_37622001_1 - 0.032 13.3 14.1 0.08 12.0 14.1 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) LAB_N PF07578.9 001253414.1_37622001_1 - 0.033 14.1 2.4 0.59 10.1 0.5 2.7 2 0 0 2 2 2 0 Lipid A Biosynthesis N-terminal domain DUF872 PF05915.10 001253414.1_37622001_1 - 0.099 12.8 2.3 0.1 12.7 0.2 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) Phtf-FEM1B_bdg PF12129.6 001253414.1_37622001_1 - 5.3 6.7 8.3 2.1 8.1 0.8 2.4 2 0 0 2 2 2 0 Male germ-cell putative homeodomain transcription factor V1R PF03402.12 001253418.1_37622001_1 - 4.9e-38 131.1 8.5 6.3e-38 130.8 8.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253418.1_37622001_1 - 3.5e-10 39.3 9.3 6e-10 38.6 9.3 1.3 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MMPL PF03176.13 001253418.1_37622001_1 - 2.1 7.0 8.8 0.66 8.7 0.3 2.7 2 1 0 2 2 2 0 MMPL family V1R PF03402.12 001253423.1_37622001_1 - 7e-34 117.5 14.8 8.9e-34 117.2 14.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253423.1_37622001_1 - 1.5e-10 40.5 17.3 2.4e-10 39.9 17.3 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253434.1_37622001_1 - 1.2e-36 126.6 13.6 1.6e-36 126.2 13.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253434.1_37622001_1 - 1.7e-10 40.4 18.9 2.1e-10 40.1 18.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253434.1_37622001_1 - 0.002 17.2 13.7 0.003 16.7 13.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Halogen_Hydrol PF10112.7 001253434.1_37622001_1 - 0.12 12.2 0.2 0.12 12.2 0.2 2.5 2 1 0 3 3 3 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein V1R PF03402.12 001253435.1_37622001_1 - 1.9e-39 135.8 14.5 2.6e-39 135.3 14.5 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253435.1_37622001_1 - 6.4e-10 38.5 22.7 8.9e-10 38.0 22.7 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253435.1_37622001_1 - 0.0048 16.0 18.8 0.0079 15.3 18.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253442.1_37623001_1 - 2e-35 122.6 13.9 2.7e-35 122.2 13.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253442.1_37623001_1 - 1.3e-09 37.5 14.6 1.5e-09 37.2 14.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253442.1_37623001_1 - 0.0036 16.5 14.3 0.0058 15.8 14.3 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253449.1_37623001_1 - 1.2e-38 133.1 11.0 1.6e-38 132.8 11.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253449.1_37623001_1 - 1.5e-07 30.7 16.0 2.5e-07 30.0 16.0 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253454.1_37622001_1 - 1.3e-35 123.2 13.2 1.8e-35 122.8 13.2 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253454.1_37622001_1 - 3.1e-07 29.7 16.1 3.8e-07 29.4 16.1 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) FGGY_N PF00370.19 001253454.1_37622001_1 - 0.012 15.1 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain V1R PF03402.12 001253455.1_37622001_1 - 9.3e-41 140.1 13.7 1.2e-40 139.7 13.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253455.1_37622001_1 - 2e-08 33.6 20.0 2.6e-08 33.2 20.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253455.1_37622001_1 - 0.0022 17.2 10.9 0.0029 16.7 10.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253462.1_37622001_1 - 4.3e-32 111.7 12.9 5.5e-32 111.3 12.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253462.1_37622001_1 - 4.6e-12 45.5 13.1 6.3e-12 45.1 13.1 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253462.1_37622001_1 - 8.4e-07 28.4 11.2 8.4e-07 28.4 11.2 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253463.1_37622001_1 - 1.9e-35 122.6 19.2 2.6e-35 122.2 19.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253463.1_37622001_1 - 6e-09 35.3 24.0 7.2e-09 35.0 24.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253469.1_37622001_1 - 2.6e-37 128.8 14.1 3.3e-37 128.4 14.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253469.1_37622001_1 - 6.7e-11 41.7 15.5 8.2e-11 41.4 15.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253469.1_37622001_1 - 0.008 15.3 9.9 0.012 14.8 9.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253473.1_37622001_1 - 6.8e-38 130.7 13.1 8.4e-38 130.4 13.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253473.1_37622001_1 - 1.9e-09 36.9 13.8 2.4e-09 36.6 13.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) UT PF03253.12 001253473.1_37622001_1 - 0.0021 17.1 4.1 0.0037 16.3 4.1 1.4 1 0 0 1 1 1 1 Urea transporter GP4 PF03010.12 001253473.1_37622001_1 - 0.018 14.8 0.0 0.038 13.8 0.0 1.4 1 0 0 1 1 1 0 GP4 V1R PF03402.12 001253482.1_37622001_1 - 5e-36 124.5 11.0 6.8e-36 124.1 11.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253482.1_37622001_1 - 1.4e-15 57.0 13.1 1.8e-15 56.7 13.1 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253482.1_37622001_1 - 4e-05 22.9 9.3 5.8e-05 22.3 9.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253487.1_37622001_1 - 3.1e-34 118.7 8.0 4.1e-34 118.3 8.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253487.1_37622001_1 - 3.6e-14 52.4 7.0 4.7e-14 52.1 7.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Cation_ATPase_C PF00689.19 001253487.1_37622001_1 - 0.36 10.4 6.8 0.022 14.4 1.5 1.6 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus V1R PF03402.12 001253491.1_37622001_1 - 3.4e-34 118.5 19.0 4.7e-34 118.1 19.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253491.1_37622001_1 - 1.1e-11 44.2 23.1 1.4e-11 44.0 23.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Chaperone_III PF07824.10 001253491.1_37622001_1 - 0.068 13.3 0.2 0.14 12.3 0.2 1.5 1 0 0 1 1 1 0 Type III secretion chaperone domain 7tm_1 PF00001.19 001253491.1_37622001_1 - 1.4 8.0 14.8 2.1 7.4 14.8 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253505.1_37622001_1 - 1.8e-29 103.0 15.9 2.6e-29 102.5 15.9 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001253505.1_37622001_1 - 0.0087 15.2 17.0 0.015 14.4 17.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253509.1_37622001_1 - 3.5e-35 121.8 12.0 4.4e-35 121.5 12.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253509.1_37622001_1 - 1e-10 41.1 10.3 1.2e-10 40.8 10.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253509.1_37622001_1 - 0.44 9.6 14.4 1.8 7.6 14.9 1.8 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253521.1_37622001_1 - 1.9e-46 158.7 16.4 2.7e-46 158.2 16.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253521.1_37622001_1 - 4.5e-13 48.9 22.5 5.4e-13 48.6 22.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253521.1_37622001_1 - 4.7e-05 22.6 18.9 5.9e-05 22.3 18.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253526.1_37622001_1 - 1e-41 143.2 15.7 1.3e-41 142.8 15.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253526.1_37622001_1 - 4.1e-11 42.4 14.3 4.9e-11 42.2 14.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Mntp PF02659.13 001253526.1_37622001_1 - 0.0077 15.9 0.2 0.0077 15.9 0.2 2.1 2 0 0 2 2 2 1 Putative manganese efflux pump KCH PF16944.3 001253526.1_37622001_1 - 0.21 11.2 2.2 0.32 10.6 1.7 1.8 1 1 0 1 1 1 0 Fungal potassium channel V1R PF03402.12 001253533.1_37622001_1 - 4.7e-37 127.9 10.0 6.2e-37 127.5 10.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253533.1_37622001_1 - 2.8e-14 52.8 12.4 3.6e-14 52.5 12.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253533.1_37622001_1 - 0.0046 16.1 11.5 0.0087 15.2 11.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253544.1_37622001_1 - 2.6e-47 161.6 12.2 3e-47 161.3 12.2 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253544.1_37622001_1 - 3.5e-11 42.6 11.4 4.6e-11 42.2 11.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253557.1_37622001_1 - 2.2e-40 138.8 12.9 2.8e-40 138.5 12.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253557.1_37622001_1 - 2e-12 46.7 13.4 2.4e-12 46.4 13.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) GP4 PF03010.12 001253557.1_37622001_1 - 0.012 15.4 0.0 0.024 14.5 0.0 1.5 1 0 0 1 1 1 0 GP4 V1R PF03402.12 001253558.1_37622001_1 - 4e-36 124.9 4.2 5.1e-36 124.5 4.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253558.1_37622001_1 - 2.7e-10 39.7 7.5 3.5e-10 39.4 7.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MMPL PF03176.13 001253558.1_37622001_1 - 0.52 9.1 3.8 0.54 9.0 0.3 2.1 2 0 0 2 2 2 0 MMPL family V1R PF03402.12 001253560.1_37623001_1 - 1.5e-41 142.7 13.8 1.9e-41 142.3 13.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253560.1_37623001_1 - 6.2e-11 41.8 14.6 7.5e-11 41.6 14.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253560.1_37623001_1 - 0.018 14.1 10.5 0.015 14.4 8.3 1.7 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253562.1_37622001_1 - 6.9e-45 153.6 15.5 8.3e-45 153.3 15.5 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253562.1_37622001_1 - 9.4e-10 37.9 16.4 1.2e-09 37.6 16.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF996 PF06195.11 001253562.1_37622001_1 - 0.11 12.7 0.2 0.11 12.7 0.2 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF996) V1R PF03402.12 001253569.1_37622001_1 - 7.2e-39 133.9 8.0 9.3e-39 133.5 8.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253569.1_37622001_1 - 1.1e-13 50.8 6.8 1.4e-13 50.5 6.8 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253569.1_37622001_1 - 0.00022 20.4 4.4 0.0003 20.0 4.4 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253570.1_37622001_1 - 4.3e-37 128.1 10.5 5.4e-37 127.7 10.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253570.1_37622001_1 - 7.4e-10 38.3 12.3 9.1e-10 38.0 12.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253570.1_37622001_1 - 0.026 13.6 8.9 0.034 13.3 8.9 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) GP4 PF03010.12 001253570.1_37622001_1 - 0.031 14.1 0.0 0.065 13.0 0.0 1.4 1 0 0 1 1 1 0 GP4 V1R PF03402.12 001253571.1_37622001_1 - 3.9e-33 115.1 15.2 5.4e-33 114.6 15.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253571.1_37622001_1 - 6.3e-11 41.8 19.2 7.6e-11 41.5 19.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253572.1_37622001_1 - 6.5e-29 101.2 14.7 8e-29 100.9 14.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253572.1_37622001_1 - 6.9e-06 25.3 15.0 1.9e-05 23.8 15.0 1.7 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253573.1_37622001_1 - 2.3e-43 148.6 16.6 3.2e-43 148.2 16.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253573.1_37622001_1 - 1.1e-13 50.8 20.5 1.4e-13 50.5 20.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253573.1_37622001_1 - 0.0073 15.4 15.5 0.0099 15.0 15.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253574.1_37622001_1 - 7.1e-35 120.8 11.0 9e-35 120.4 11.0 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253574.1_37622001_1 - 1.3e-14 53.9 11.4 1.6e-14 53.6 11.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MMPL PF03176.13 001253574.1_37622001_1 - 0.021 13.6 0.5 0.034 12.9 0.5 1.4 1 0 0 1 1 1 0 MMPL family 7tm_1 PF00001.19 001253574.1_37622001_1 - 0.056 12.5 10.7 0.07 12.2 10.7 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253577.1_37622001_1 - 1.9e-46 158.7 15.1 2.6e-46 158.3 15.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253577.1_37622001_1 - 3.2e-12 46.0 19.1 3.9e-12 45.8 19.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253577.1_37622001_1 - 3e-08 33.1 22.2 4.3e-08 32.6 22.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253578.1_37622001_1 - 9.3e-40 136.8 14.7 1.2e-39 136.5 14.7 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253578.1_37622001_1 - 2.2e-07 30.1 15.6 2.9e-07 29.8 15.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) GP4 PF03010.12 001253578.1_37622001_1 - 0.03 14.1 0.0 0.072 12.9 0.0 1.6 1 0 0 1 1 1 0 GP4 7tm_1 PF00001.19 001253578.1_37622001_1 - 1.1 8.3 10.0 1.7 7.6 10.0 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253579.1_37622001_1 - 5.3e-42 144.1 10.6 6.7e-42 143.8 10.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253579.1_37622001_1 - 5.2e-12 45.3 10.6 7.8e-12 44.8 10.6 1.2 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253579.1_37622001_1 - 0.018 14.2 7.5 0.027 13.6 7.5 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253581.1_37622001_1 - 4.1e-35 121.6 10.9 5.7e-35 121.1 10.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253581.1_37622001_1 - 8.7e-11 41.3 15.2 1.2e-10 40.9 15.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253581.1_37622001_1 - 0.034 13.3 7.9 0.049 12.7 7.9 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253582.1_37622001_1 - 1.6e-39 136.0 16.7 2.2e-39 135.5 16.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253582.1_37622001_1 - 9.9e-13 47.7 21.1 1.2e-12 47.5 21.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MMPL PF03176.13 001253582.1_37622001_1 - 0.18 10.5 1.7 0.39 9.5 0.3 2.0 2 0 0 2 2 2 0 MMPL family 7tm_1 PF00001.19 001253582.1_37622001_1 - 0.34 10.0 12.4 0.47 9.5 12.4 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253583.1_37622001_1 - 3.6e-35 121.7 19.1 4.7e-35 121.4 19.1 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253583.1_37622001_1 - 2.2e-10 40.0 19.8 2.9e-10 39.6 19.8 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253583.1_37622001_1 - 0.015 14.4 10.1 0.023 13.8 10.1 1.3 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253584.1_37622001_1 - 5.6e-36 124.4 14.9 5.6e-36 124.4 14.9 1.4 1 1 1 2 2 2 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253584.1_37622001_1 - 2.3e-07 30.1 18.9 3e-07 29.7 18.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253584.1_37622001_1 - 0.00025 20.3 11.5 0.00032 19.9 11.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253585.1_37622001_1 - 6.6e-42 143.8 13.0 8.7e-42 143.4 13.0 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001253585.1_37622001_1 - 0.00013 21.1 16.6 0.00019 20.6 16.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253587.1_37622001_1 - 2.8e-39 135.2 16.7 3.8e-39 134.8 16.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253587.1_37622001_1 - 1.3e-12 47.3 20.2 1.6e-12 47.0 20.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Chaperone_III PF07824.10 001253587.1_37622001_1 - 0.08 13.0 0.2 0.18 11.9 0.2 1.5 1 0 0 1 1 1 0 Type III secretion chaperone domain 7tm_1 PF00001.19 001253587.1_37622001_1 - 6.5 5.8 12.8 9.5 5.2 12.6 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253588.1_37622001_1 - 1.9e-32 112.8 14.0 2.6e-32 112.4 14.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253588.1_37622001_1 - 4.2e-10 39.1 16.7 5e-10 38.8 16.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253590.1_37622001_1 - 2.3e-47 161.7 15.4 3.2e-47 161.3 15.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253590.1_37622001_1 - 3.7e-10 39.3 20.2 4.4e-10 39.0 20.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253590.1_37622001_1 - 3.3e-05 23.1 18.0 4.5e-05 22.7 18.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253591.1_37622001_1 - 3e-40 138.4 11.8 3.8e-40 138.0 11.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253591.1_37622001_1 - 2.5e-09 36.5 9.7 3.1e-09 36.2 9.7 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MMPL PF03176.13 001253591.1_37622001_1 - 0.0066 15.3 2.0 0.0068 15.2 0.1 1.8 2 0 0 2 2 2 1 MMPL family V1R PF03402.12 001253592.1_37622001_1 - 2.8e-34 118.8 13.3 3.3e-34 118.6 13.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253592.1_37622001_1 - 8.2e-08 31.6 14.5 9.2e-08 31.4 14.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) GCM PF03615.13 001253592.1_37622001_1 - 0.096 12.4 0.1 0.24 11.1 0.0 1.6 2 0 0 2 2 2 0 GCM motif protein V1R PF03402.12 001253595.1_37622001_1 - 2e-40 139.0 14.1 2.7e-40 138.5 14.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253595.1_37622001_1 - 8.8e-10 38.0 23.1 1.5e-09 37.3 23.1 1.4 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253595.1_37622001_1 - 0.24 10.5 12.6 0.39 9.8 12.6 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253596.1_37622001_1 - 1.6e-37 129.4 19.7 2.1e-37 129.1 19.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253596.1_37622001_1 - 4e-08 32.6 25.0 4.9e-08 32.3 25.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253596.1_37622001_1 - 0.029 13.5 16.1 0.039 13.0 15.5 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Cation_ATPase_C PF00689.19 001253596.1_37622001_1 - 0.12 11.9 13.1 0.086 12.4 0.8 2.6 2 1 0 2 2 2 0 Cation transporting ATPase, C-terminus V1R PF03402.12 001253597.1_37622001_1 - 4.5e-33 114.9 14.2 6.1e-33 114.4 14.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253597.1_37622001_1 - 3.4e-10 39.4 18.8 4.1e-10 39.1 18.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253598.1_37622001_1 - 5.7e-33 114.5 16.4 7.7e-33 114.1 16.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253598.1_37622001_1 - 2.3e-10 40.0 20.2 2.8e-10 39.7 20.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253599.1_37622001_1 - 1.1e-38 133.2 8.3 1.5e-38 132.8 8.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253599.1_37622001_1 - 4.2e-12 45.7 9.5 5.4e-12 45.3 9.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253599.1_37622001_1 - 0.00016 20.9 4.9 0.00022 20.4 4.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253600.1_37622001_1 - 1.8e-40 139.1 18.7 2.3e-40 138.7 18.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253600.1_37622001_1 - 5.6e-12 45.2 23.1 7.1e-12 44.9 23.1 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253600.1_37622001_1 - 0.012 14.7 17.1 0.016 14.3 17.1 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF443 PF04276.10 001253600.1_37622001_1 - 0.84 9.3 10.4 0.02 14.6 2.7 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF443) V1R PF03402.12 001253602.1_37622001_1 - 4.1e-41 141.2 8.6 5.5e-41 140.8 8.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253602.1_37622001_1 - 1.5e-12 47.2 10.8 1.8e-12 46.8 10.8 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253602.1_37622001_1 - 0.0028 16.8 10.5 0.0043 16.2 10.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253603.1_37622001_1 - 3.9e-36 124.9 15.7 5.1e-36 124.5 15.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253603.1_37622001_1 - 1.1e-08 34.5 15.7 1.4e-08 34.1 15.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253604.1_37622001_1 - 1.5e-40 139.4 13.2 2e-40 139.0 13.2 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253604.1_37622001_1 - 8.3e-13 48.0 16.9 9.9e-13 47.7 16.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253605.1_37622001_1 - 5.5e-42 144.1 7.3 7.4e-42 143.7 7.3 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253605.1_37622001_1 - 5.9e-07 28.8 12.5 1.6e-06 27.4 12.5 1.6 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253606.1_37622001_1 - 6.9e-41 140.5 9.7 9e-41 140.1 9.7 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253606.1_37622001_1 - 3.9e-07 29.4 11.6 9.4e-07 28.1 11.6 1.5 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253606.1_37622001_1 - 0.094 11.8 4.9 0.15 11.1 4.9 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253607.1_37622001_1 - 8.3e-41 140.2 13.9 1.1e-40 139.8 13.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253607.1_37622001_1 - 2.4e-11 43.2 14.4 3.1e-11 42.8 14.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253607.1_37622001_1 - 0.22 10.6 11.1 0.37 9.8 10.5 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253608.1_37622001_1 - 5.7e-46 157.1 19.4 7.3e-46 156.8 19.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253608.1_37622001_1 - 1.3e-11 44.1 23.7 1.5e-11 43.8 23.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253608.1_37622001_1 - 0.00013 21.2 18.1 0.00018 20.7 18.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253609.1_37622001_1 - 3.3e-42 144.8 17.9 3.9e-42 144.6 17.9 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253609.1_37622001_1 - 6.7e-10 38.4 19.5 9e-10 38.0 19.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253609.1_37622001_1 - 0.15 11.1 19.6 0.21 10.6 18.5 1.7 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253610.1_37622001_1 - 2.3e-32 112.5 10.6 3e-32 112.1 10.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253610.1_37622001_1 - 1.7e-08 33.8 12.9 2.5e-08 33.2 12.9 1.3 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253612.1_37622001_1 - 1.8e-41 142.4 14.0 2.3e-41 142.0 14.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253612.1_37622001_1 - 6.6e-11 41.7 16.7 8.3e-11 41.4 16.7 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253618.1_37622001_1 - 8.2e-38 130.4 8.5 1.1e-37 130.0 8.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253618.1_37622001_1 - 1.7e-11 43.7 11.2 2e-11 43.4 11.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253619.1_37622001_1 - 2.9e-47 161.4 16.5 3.5e-47 161.1 16.5 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253619.1_37622001_1 - 2e-10 40.2 18.6 2.6e-10 39.8 18.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253619.1_37622001_1 - 0.012 14.8 18.1 0.016 14.3 18.0 1.3 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253620.1_37622001_1 - 1.5e-45 155.8 17.5 1.8e-45 155.5 17.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253620.1_37622001_1 - 2e-09 36.9 19.9 2.6e-09 36.5 19.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7TM_GPCR_Srv PF10323.7 001253620.1_37622001_1 - 8e-05 22.0 13.6 0.0001 21.6 13.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_1 PF00001.19 001253620.1_37622001_1 - 0.23 10.5 20.8 0.35 9.9 19.5 1.7 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253621.1_37622001_1 - 8.7e-45 153.3 13.7 1.2e-44 152.8 13.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253621.1_37622001_1 - 2.2e-09 36.7 23.7 2.6e-09 36.5 23.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253621.1_37622001_1 - 3.1e-05 23.2 18.6 4.3e-05 22.8 18.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253622.1_37622001_1 - 1.4e-40 139.5 16.8 1.9e-40 139.0 16.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253622.1_37622001_1 - 6.9e-11 41.7 19.8 8.5e-11 41.4 19.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253622.1_37622001_1 - 2.1e-06 27.1 21.9 2.9e-06 26.6 21.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Acyltransferase PF01553.19 001253622.1_37622001_1 - 0.035 13.6 0.0 0.089 12.3 0.0 1.7 1 0 0 1 1 1 0 Acyltransferase V1R PF03402.12 001253625.1_37622001_1 - 6.2e-51 173.4 14.7 7.4e-51 173.2 14.7 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253625.1_37622001_1 - 4.8e-10 38.9 16.6 5.7e-10 38.7 16.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253625.1_37622001_1 - 0.067 12.3 14.9 0.12 11.4 15.0 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) HEV_ORF1 PF02444.14 001253625.1_37622001_1 - 0.087 13.3 1.2 1.1 9.7 0.2 2.5 2 0 0 2 2 2 0 Hepatitis E virus ORF-2 (Putative capsid protein) V1R PF03402.12 001253626.1_37622001_1 - 1.2e-35 123.3 15.8 1.6e-35 122.9 15.8 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253626.1_37622001_1 - 7.2e-19 67.9 17.1 8.5e-19 67.6 17.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253626.1_37622001_1 - 0.00079 18.6 14.8 0.0012 18.0 14.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3421 PF11901.6 001253626.1_37622001_3 - 0.11 12.4 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3421) V1R PF03402.12 001253627.1_37622001_1 - 2.1e-42 145.5 13.9 2.1e-42 145.5 13.9 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253627.1_37622001_1 - 2.6e-07 29.9 19.9 3.9e-07 29.3 19.9 1.2 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) Mtp PF03821.14 001253627.1_37622001_1 - 0.25 10.8 9.3 0.02 14.4 4.6 1.5 2 0 0 2 2 2 0 Golgi 4-transmembrane spanning transporter V1R PF03402.12 001253628.1_37622001_1 - 5.7e-41 140.7 10.3 7.2e-41 140.4 10.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253628.1_37622001_1 - 1.3e-09 37.5 9.9 1.5e-09 37.3 9.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF4389 PF14333.4 001253628.1_37622001_1 - 7.1 6.5 10.1 15 5.5 0.0 4.1 4 1 0 4 4 4 0 Domain of unknown function (DUF4389) V1R PF03402.12 001253629.1_37622001_1 - 3.2e-41 141.6 13.9 4e-41 141.3 13.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253629.1_37622001_1 - 4.6e-11 42.2 17.9 6.4e-11 41.8 17.9 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253629.1_37622001_1 - 0.25 10.4 14.9 0.32 10.0 14.9 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253630.1_37622001_1 - 4.1e-42 144.5 10.8 5.2e-42 144.2 10.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253630.1_37622001_1 - 2.7e-10 39.7 14.6 3.5e-10 39.3 14.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253630.1_37622001_1 - 0.0018 17.4 10.9 0.0026 16.9 10.9 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253631.1_37622001_1 - 6.2e-41 140.6 13.2 8.1e-41 140.3 13.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253631.1_37622001_1 - 1.3e-14 53.9 15.4 1.6e-14 53.6 15.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253631.1_37622001_1 - 0.016 14.3 12.2 0.025 13.7 12.2 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253632.1_37622001_1 - 4.4e-20 72.3 0.0 5.5e-20 72.0 0.0 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R V1R PF03402.12 001253633.1_37622001_1 - 1.9e-28 99.7 0.0 2.6e-28 99.3 0.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R V1R PF03402.12 001253635.1_37622001_1 - 4.8e-40 137.7 16.0 6.6e-40 137.3 16.0 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253635.1_37622001_1 - 1.1e-06 27.9 21.6 1.6e-06 27.4 21.6 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253636.1_37622001_1 - 8e-31 107.5 13.5 8e-31 107.5 13.5 1.8 1 1 1 2 2 2 2 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253636.1_37622001_1 - 7.7e-08 31.7 17.4 9.8e-08 31.3 17.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253637.1_37622001_1 - 1.2e-38 133.2 15.1 1.5e-38 132.8 15.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253637.1_37622001_1 - 4.3e-11 42.3 19.2 5.9e-11 41.9 19.2 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253638.1_37622001_1 - 5.8e-34 117.8 15.0 8.8e-34 117.2 15.0 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253638.1_37622001_1 - 4.4e-13 48.9 18.1 5.3e-13 48.6 18.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253638.1_37622001_1 - 0.061 12.4 12.4 0.065 12.3 11.5 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253640.1_37622001_1 - 7.9e-41 140.3 13.0 1e-40 139.9 13.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253640.1_37622001_1 - 2.3e-11 43.2 13.1 2.8e-11 43.0 13.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253641.1_37622001_1 - 3.6e-43 148.0 17.1 4.7e-43 147.6 17.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001253641.1_37622001_1 - 0.008 15.3 23.0 0.013 14.7 23.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253643.1_37622001_1 - 8.9e-44 149.9 16.9 1.2e-43 149.5 16.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253643.1_37622001_1 - 6.1e-12 45.1 25.2 7.5e-12 44.8 25.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253643.1_37622001_1 - 1e-05 24.8 20.3 1.3e-05 24.4 20.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253644.1_37622001_1 - 3.3e-37 128.4 22.3 4.2e-37 128.1 22.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253644.1_37622001_1 - 1.4e-10 40.6 27.8 1.7e-10 40.4 27.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253644.1_37622001_1 - 0.17 10.9 26.3 0.42 9.7 26.0 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253645.1_37622001_1 - 4.7e-36 124.6 15.2 6.5e-36 124.2 15.2 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253645.1_37622001_1 - 3.7e-12 45.9 18.6 6.7e-12 45.0 18.6 1.4 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253646.1_37622001_1 - 1.2e-35 123.3 12.4 1.6e-35 122.9 12.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253646.1_37622001_1 - 5.4e-06 25.6 17.9 1e-05 24.7 17.9 1.4 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) DUF3943 PF13084.4 001253646.1_37622001_1 - 0.024 14.4 0.0 0.053 13.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3943) V1R PF03402.12 001253647.1_37622001_1 - 1.6e-45 155.7 17.0 2.1e-45 155.3 17.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253647.1_37622001_1 - 2.4e-16 59.6 17.3 2.9e-16 59.3 17.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253647.1_37622001_1 - 0.68 9.0 21.3 1.2 8.2 21.3 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253393.1_37622001_1 - 5.8e-39 134.2 5.3 7.5e-39 133.8 5.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253393.1_37622001_1 - 4.7e-07 29.1 12.8 1.2e-06 27.8 12.8 1.6 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) Peptidase_C62 PF12380.6 001253393.1_37622001_1 - 0.16 11.0 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Gill-associated viral 3C-like peptidase V1R PF03402.12 001253648.1_37623001_1 - 1e-43 149.8 17.8 1.4e-43 149.3 17.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253648.1_37623001_1 - 6.7e-13 48.3 18.3 9.7e-13 47.7 18.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253648.1_37623001_1 - 0.00018 20.7 25.5 0.0002 20.6 24.7 1.5 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253394.1_37622001_1 - 3e-39 135.1 9.8 3.7e-39 134.8 9.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253394.1_37622001_1 - 1.6e-13 50.3 7.9 2e-13 50.0 7.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253394.1_37622001_1 - 2.5e-06 26.8 8.6 3.5e-06 26.3 8.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253649.1_37622001_1 - 7.2e-39 133.9 12.3 9.6e-39 133.5 12.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253649.1_37622001_1 - 2.5e-10 39.8 12.2 3e-10 39.6 12.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253649.1_37622001_1 - 0.039 13.0 11.2 0.089 11.9 11.2 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253395.1_37622001_1 - 3.6e-41 141.4 10.6 4.4e-41 141.1 10.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253395.1_37622001_1 - 2.2e-11 43.3 11.7 2.9e-11 42.9 11.7 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253395.1_37622001_1 - 0.00024 20.3 8.7 0.00032 19.9 8.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253650.1_37622001_1 - 5e-33 114.7 10.3 6.4e-33 114.4 10.3 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253650.1_37622001_1 - 8.5e-09 34.8 8.3 1.1e-08 34.4 8.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253651.1_37622001_1 - 2.7e-46 158.2 13.0 3.1e-46 158.0 13.0 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253651.1_37622001_1 - 3.7e-08 32.7 14.9 4.8e-08 32.3 14.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253651.1_37622001_1 - 9.1e-05 21.7 9.0 0.00013 21.2 8.7 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253397.1_37622001_1 - 3.3e-43 148.1 3.0 4.4e-43 147.7 3.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253397.1_37622001_1 - 2.7e-09 36.4 0.1 4.2e-09 35.8 0.1 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253397.1_37622001_1 - 0.00016 20.9 6.3 0.00036 19.7 6.0 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TMEM169 PF15052.4 001253397.1_37622001_1 - 0.00055 19.9 0.2 0.0012 18.9 0.2 1.5 1 0 0 1 1 1 1 TMEM169 protein family V1R PF03402.12 001253652.1_37622001_1 - 2.3e-44 151.9 16.2 2.8e-44 151.6 16.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253652.1_37622001_1 - 7.1e-07 28.5 16.5 8.7e-07 28.2 16.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF996 PF06195.11 001253652.1_37622001_1 - 0.39 10.9 4.9 0.095 12.9 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF996) V1R PF03402.12 001253398.1_37623001_1 - 3.1e-44 151.5 10.5 4.2e-44 151.0 10.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253398.1_37623001_1 - 2.6e-12 46.3 9.4 4e-12 45.7 9.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253398.1_37623001_1 - 1.1e-07 31.2 12.2 1.5e-07 30.8 12.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253653.1_37622001_1 - 7.5e-43 146.9 14.7 1.1e-42 146.3 14.7 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253653.1_37622001_1 - 1.5e-12 47.2 16.4 1.9e-12 46.8 16.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253653.1_37622001_1 - 0.0002 20.6 11.5 0.00035 19.7 11.3 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253399.1_37622001_1 - 1.9e-46 158.7 8.6 2.6e-46 158.2 8.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253399.1_37622001_1 - 8.4e-15 54.5 7.6 1.1e-14 54.1 7.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253399.1_37622001_1 - 1.7e-05 24.1 13.9 2.4e-05 23.6 13.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253654.1_37622001_1 - 1.3e-36 126.5 11.5 1.7e-36 126.1 11.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253654.1_37622001_1 - 5e-16 58.5 11.7 6e-16 58.3 11.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253654.1_37622001_1 - 5.7e-05 22.4 8.5 7.7e-05 21.9 8.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253400.1_37622001_1 - 1.5e-47 162.4 7.8 1.8e-47 162.1 7.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253400.1_37622001_1 - 2.3e-18 66.2 4.6 2.9e-18 65.9 4.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253400.1_37622001_1 - 1.7e-05 24.1 12.2 2.4e-05 23.6 12.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) STE3 PF02076.13 001253400.1_37622001_1 - 0.00061 19.0 3.2 0.0019 17.4 0.9 2.3 2 0 0 2 2 2 1 Pheromone A receptor DUF2569 PF10754.7 001253400.1_37622001_1 - 1.8 8.8 8.9 0.69 10.2 5.0 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF2569) V1R PF03402.12 001253655.1_37622001_1 - 7.5e-31 107.6 11.2 7.5e-31 107.6 11.2 1.6 1 1 1 2 2 2 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253655.1_37622001_1 - 1.2e-07 31.0 15.5 1.6e-07 30.6 15.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253656.1_37622001_1 - 1.4e-42 146.0 12.5 1.4e-42 146.0 12.5 1.2 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253656.1_37622001_1 - 4.3e-08 32.5 17.2 6.4e-08 31.9 17.2 1.2 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253656.1_37622001_1 - 0.00065 18.9 9.1 0.00094 18.4 9.1 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253657.1_37622001_1 - 1.5e-37 129.5 16.5 2.2e-37 129.0 16.5 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253657.1_37622001_1 - 2.1e-12 46.7 21.7 2.8e-12 46.2 21.7 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253657.1_37622001_1 - 0.00081 18.6 10.9 0.0014 17.8 10.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253658.1_37622001_1 - 3.5e-37 128.3 12.7 4.6e-37 128.0 12.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253658.1_37622001_1 - 0.00036 19.6 18.1 0.00045 19.3 18.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF5056 PF16479.3 001253658.1_37622001_1 - 0.0047 17.0 0.1 0.014 15.5 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5056) SPA PF08616.8 001253658.1_37622001_1 - 0.068 13.0 1.5 6 6.7 0.1 2.4 2 0 0 2 2 2 0 Stabilization of polarity axis V1R PF03402.12 001253659.1_37622001_1 - 7.5e-39 133.8 11.3 1.1e-38 133.3 11.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253659.1_37622001_1 - 3.4e-16 59.1 10.3 4.1e-16 58.8 10.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253659.1_37622001_1 - 1.6e-05 24.2 7.2 2.2e-05 23.7 7.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253660.1_37622001_1 - 1.9e-36 125.9 10.5 2.3e-36 125.7 10.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253660.1_37622001_1 - 1.9e-08 33.7 12.7 2.3e-08 33.4 12.7 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253660.1_37622001_1 - 3.4 6.7 8.2 4.8 6.2 8.1 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253406.1_37622001_1 - 1.1e-39 136.5 13.5 1.4e-39 136.2 13.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253406.1_37622001_1 - 6.4e-11 41.8 15.4 9.2e-11 41.3 15.4 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253406.1_37622001_1 - 0.023 13.8 14.2 0.034 13.2 14.2 1.3 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF443 PF04276.10 001253406.1_37622001_1 - 6.2 6.4 10.4 0.033 13.9 0.7 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF443) V1R PF03402.12 001253661.1_37622001_1 - 1.2e-37 129.8 9.7 1.2e-37 129.8 9.7 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253661.1_37622001_1 - 3.8e-07 29.4 12.3 5.4e-07 28.9 12.3 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253661.1_37622001_1 - 0.03 13.4 9.8 0.042 12.9 9.4 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253407.1_37622001_1 - 1.5e-41 142.7 12.4 1.8e-41 142.4 12.4 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253407.1_37622001_1 - 1.4e-06 27.5 16.3 2.2e-06 26.9 16.3 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253662.1_37622001_1 - 5.5e-36 124.4 12.9 7e-36 124.1 12.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253662.1_37622001_1 - 9.2e-11 41.3 13.3 1.1e-10 41.0 13.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF4271 PF14093.4 001253662.1_37622001_1 - 2.7 7.7 16.1 1.1 9.1 0.9 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4271) V1R PF03402.12 001253408.1_37622001_1 - 3.8e-37 128.2 16.7 5.1e-37 127.8 16.7 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253408.1_37622001_1 - 8.5e-05 21.7 19.6 0.00012 21.1 19.6 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253663.1_37622001_1 - 1.1e-36 126.7 12.6 1.4e-36 126.4 12.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253663.1_37622001_1 - 6.5e-13 48.3 12.6 7.8e-13 48.1 12.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) GP4 PF03010.12 001253663.1_37622001_1 - 0.0012 18.7 0.1 0.0024 17.7 0.1 1.5 1 0 0 1 1 1 1 GP4 Avian_gp85 PF03708.12 001253663.1_37622001_1 - 0.021 13.9 0.0 0.035 13.2 0.0 1.3 1 0 0 1 1 1 0 Avian retrovirus envelope protein, gp85 7tm_1 PF00001.19 001253663.1_37622001_1 - 0.03 13.4 9.4 0.039 13.0 9.4 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253409.1_37622001_1 - 9.4e-46 156.4 13.8 1.3e-45 156.0 13.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253409.1_37622001_1 - 3.5e-16 59.1 14.7 4.5e-16 58.7 14.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253409.1_37622001_1 - 1.2e-08 34.4 18.3 1.2e-08 34.4 17.7 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ndc1_Nup PF09531.8 001253409.1_37622001_1 - 5.2 5.5 19.0 1.4e+02 0.8 19.0 2.1 1 1 0 1 1 1 0 Nucleoporin protein Ndc1-Nup V1R PF03402.12 001253664.1_37623001_1 - 1.5e-40 139.4 6.8 2.2e-40 138.8 6.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253664.1_37623001_1 - 8.7e-11 41.3 11.6 1.2e-10 40.9 11.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253664.1_37623001_1 - 0.00036 19.7 2.3 0.00046 19.4 2.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253665.1_37622001_1 - 1.1e-41 143.1 12.8 1.3e-41 142.8 12.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253665.1_37622001_1 - 4.4e-13 48.9 14.5 6.4e-13 48.3 14.5 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) GP4 PF03010.12 001253665.1_37622001_1 - 0.011 15.6 0.1 0.02 14.7 0.1 1.4 1 0 0 1 1 1 0 GP4 Halogen_Hydrol PF10112.7 001253665.1_37622001_1 - 0.21 11.4 1.7 0.38 10.6 0.1 2.1 1 1 1 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein V1R PF03402.12 001253411.1_37622001_1 - 1.6e-32 113.1 3.5 2.2e-32 112.6 3.5 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253411.1_37622001_1 - 5.2e-06 25.7 12.7 1.9e-05 23.8 12.7 1.9 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) TMEM171 PF15471.4 001253411.1_37622001_1 - 1.3 7.8 4.0 0.38 9.6 0.3 1.9 2 0 0 2 2 2 0 Transmembrane protein family 171 V1R PF03402.12 001253666.1_37622001_1 - 1.3e-35 123.2 8.5 1.3e-35 123.2 8.5 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253666.1_37622001_1 - 0.00078 18.5 16.8 0.0021 17.1 16.8 1.6 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) DUF5134 PF17197.2 001253666.1_37622001_1 - 0.061 13.1 3.7 0.14 12.0 3.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5134) Sigma70_r2 PF04542.12 001253666.1_37622001_1 - 0.11 12.2 0.1 0.24 11.1 0.1 1.5 1 0 0 1 1 1 0 Sigma-70 region 2 7tm_1 PF00001.19 001253666.1_37622001_1 - 0.3 10.2 10.3 0.068 12.3 7.1 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF2417 PF10329.7 001253666.1_37622001_1 - 7.5 5.8 9.2 1.1 8.4 2.6 2.3 2 0 0 2 2 2 0 Region of unknown function (DUF2417) V1R PF03402.12 001253413.1_37622001_1 - 5.7e-39 134.2 9.8 7.2e-39 133.9 9.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253413.1_37622001_1 - 3.3e-10 39.5 11.2 4.4e-10 39.0 11.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253413.1_37622001_1 - 0.012 14.7 10.8 0.016 14.3 10.8 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) CfAFP PF05264.9 001253413.1_37622001_1 - 0.018 14.9 0.1 0.033 14.0 0.1 1.4 1 0 0 1 1 1 0 Choristoneura fumiferana antifreeze protein (CfAFP) DUF872 PF05915.10 001253413.1_37622001_1 - 0.91 9.7 4.6 1.3 9.1 0.2 2.9 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF872) V1R PF03402.12 001253668.1_37622001_1 - 5.4e-35 121.2 8.4 7e-35 120.8 8.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253668.1_37622001_1 - 1.6e-14 53.6 5.8 2.1e-14 53.2 5.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253669.1_37622001_1 - 2.4e-36 125.6 20.0 3e-36 125.3 20.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253669.1_37622001_1 - 1.3e-07 30.9 21.8 1.7e-07 30.5 21.8 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253669.1_37622001_1 - 0.4 9.7 18.2 0.92 8.5 17.9 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253415.1_37622001_1 - 1.8e-39 135.8 8.5 2.4e-39 135.4 8.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253415.1_37622001_1 - 1.2e-10 40.8 12.3 1.7e-10 40.4 12.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253670.1_37622001_1 - 2.8e-30 105.7 14.7 3.7e-30 105.3 14.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253670.1_37622001_1 - 2.3e-09 36.7 17.1 2.7e-09 36.5 17.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) CfAFP PF05264.9 001253670.1_37622001_1 - 0.021 14.7 0.3 0.036 13.9 0.3 1.3 1 0 0 1 1 1 0 Choristoneura fumiferana antifreeze protein (CfAFP) 7tm_1 PF00001.19 001253670.1_37622001_1 - 0.043 12.9 12.6 0.058 12.5 12.6 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253416.1_37622001_1 - 1.3e-40 139.6 9.7 1.6e-40 139.3 9.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253416.1_37622001_1 - 6.1e-13 48.4 11.8 1e-12 47.7 11.8 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253416.1_37622001_1 - 0.21 10.7 10.5 0.17 10.9 9.8 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253671.1_37622001_1 - 1.1e-25 90.7 11.9 1.4e-25 90.3 11.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253671.1_37622001_1 - 3.4e-08 32.8 18.2 4.5e-08 32.4 18.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253671.1_37622001_1 - 0.0013 17.9 15.7 0.049 12.7 15.6 2.2 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253417.1_37622001_1 - 1.3e-37 129.7 8.1 1.6e-37 129.4 8.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253417.1_37622001_1 - 1.7e-12 47.0 6.5 2e-12 46.7 6.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MMPL PF03176.13 001253417.1_37622001_1 - 0.015 14.1 0.6 0.015 14.1 0.6 2.2 3 0 0 3 3 3 0 MMPL family V1R PF03402.12 001253672.1_37622001_1 - 2.7e-40 138.5 11.3 3.6e-40 138.1 11.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253672.1_37622001_1 - 2.3e-12 46.5 13.8 2.9e-12 46.2 13.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253672.1_37622001_1 - 0.013 14.6 10.4 0.019 14.1 10.4 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF4079 PF13301.4 001253672.1_37622001_1 - 0.26 11.3 4.8 0.12 12.3 1.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4079) V1R PF03402.12 001253673.1_37622001_1 - 1.9e-36 126.0 13.3 2.5e-36 125.5 13.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253673.1_37622001_1 - 8e-08 31.6 18.5 1e-07 31.3 18.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253673.1_37622001_1 - 0.026 13.7 11.2 0.035 13.2 11.2 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253419.1_37622001_1 - 3.6e-40 138.1 10.2 4.8e-40 137.7 10.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253419.1_37622001_1 - 7.9e-10 38.2 16.2 1.5e-09 37.3 16.2 1.4 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253419.1_37622001_1 - 0.0011 18.2 10.6 0.0018 17.5 10.6 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PAP2 PF01569.19 001253419.1_37622001_1 - 0.6 9.8 6.8 0.35 10.5 2.7 2.5 2 0 0 2 2 2 0 PAP2 superfamily V1R PF03402.12 001253674.1_37622001_1 - 6.5e-39 134.0 10.4 6.5e-39 134.0 10.4 1.2 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253674.1_37622001_1 - 1.6e-05 24.1 16.8 2.4e-05 23.5 16.8 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V_ATPase_I PF01496.17 001253674.1_37622001_1 - 0.23 9.2 0.2 0.29 8.8 0.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family 7tm_1 PF00001.19 001253674.1_37622001_1 - 0.29 10.2 12.1 0.45 9.6 12.1 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253420.1_37622001_1 - 2e-39 135.7 12.3 2.9e-39 135.1 12.3 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253420.1_37622001_1 - 7.4e-13 48.1 16.6 9.4e-13 47.8 16.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253420.1_37622001_1 - 0.014 14.5 11.0 0.021 13.9 11.0 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253675.1_37622001_1 - 9.8e-35 120.3 13.4 1.2e-34 120.0 13.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253675.1_37622001_1 - 1.8e-06 27.1 15.0 2.2e-06 26.9 15.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253675.1_37622001_1 - 0.0052 15.9 10.9 0.007 15.5 10.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253421.1_37622001_1 - 3.7e-45 154.5 15.1 4.9e-45 154.1 15.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253421.1_37622001_1 - 2.2e-13 49.9 15.9 2.6e-13 49.6 15.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253421.1_37622001_1 - 0.0073 15.4 12.9 0.01 15.0 12.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF5134 PF17197.2 001253421.1_37622001_1 - 0.0083 15.9 1.8 0.018 14.8 1.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5134) V1R PF03402.12 001253422.1_37622001_1 - 1.3e-42 146.2 9.5 1.6e-42 145.8 9.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253422.1_37622001_1 - 4.7e-14 52.1 12.1 5.5e-14 51.8 12.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MMPL PF03176.13 001253422.1_37622001_1 - 0.041 12.7 0.2 0.091 11.5 0.2 1.5 1 0 0 1 1 1 0 MMPL family DUF5134 PF17197.2 001253422.1_37622001_1 - 0.056 13.2 0.1 0.094 12.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5134) Gemini_mov PF01708.14 001253422.1_37622001_1 - 0.9 9.2 2.9 8.1 6.1 0.1 2.9 2 0 0 2 2 2 0 Geminivirus putative movement protein V1R PF03402.12 001253424.1_37622001_1 - 4.9e-41 141.0 13.5 6.1e-41 140.7 13.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253424.1_37622001_1 - 2.7e-11 43.0 19.3 4.3e-11 42.3 19.3 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) GP4 PF03010.12 001253424.1_37622001_1 - 0.0022 17.8 0.1 0.004 17.0 0.1 1.4 1 0 0 1 1 1 1 GP4 Halogen_Hydrol PF10112.7 001253424.1_37622001_1 - 0.3 11.0 1.9 0.46 10.4 0.1 2.1 1 1 1 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein V1R PF03402.12 001253425.1_37622001_1 - 5.4e-41 140.8 9.9 7e-41 140.5 9.9 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253425.1_37622001_1 - 4.4e-07 29.2 12.1 9.8e-07 28.0 12.1 1.5 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253425.1_37622001_1 - 0.12 11.5 5.4 0.19 10.8 5.4 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253426.1_37622001_1 - 4.7e-34 118.1 16.3 6.2e-34 117.7 16.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253426.1_37622001_1 - 5e-05 22.4 22.0 6e-05 22.2 22.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253427.1_37622001_1 - 1.4e-36 126.4 14.8 1.8e-36 126.0 14.8 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253427.1_37622001_1 - 1.8e-06 27.2 19.0 2.1e-06 27.0 19.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253427.1_37622001_1 - 0.00021 20.5 12.3 0.00028 20.1 12.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253428.1_37622001_1 - 2.3e-42 145.3 12.6 2.9e-42 145.0 12.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253428.1_37622001_1 - 5.5e-13 48.6 14.9 6.9e-13 48.2 14.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253428.1_37622001_1 - 0.017 14.2 11.3 0.024 13.7 11.3 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) CbtB PF09489.8 001253428.1_37622001_1 - 0.26 11.3 3.0 0.41 10.7 1.2 2.3 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtB) V1R PF03402.12 001253429.1_37622001_1 - 3.2e-31 108.8 15.0 4.1e-31 108.4 15.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253429.1_37622001_1 - 2.4e-05 23.5 17.2 5.7e-05 22.2 17.2 1.6 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253430.1_37622001_1 - 8e-38 130.4 12.2 8e-38 130.4 12.2 1.4 1 1 1 2 2 2 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253430.1_37622001_1 - 7e-08 31.8 16.2 1e-07 31.2 16.2 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253430.1_37622001_1 - 0.00011 21.5 10.4 0.00014 21.1 10.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253431.1_37622001_1 - 2.2e-27 96.2 17.1 3e-27 95.8 17.1 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253431.1_37622001_1 - 9.8e-08 31.3 18.4 1.2e-07 31.1 18.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253431.1_37622001_1 - 0.0027 16.9 11.9 0.0036 16.4 11.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253432.1_37622001_1 - 1.4e-28 100.1 15.7 1.9e-28 99.7 15.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253432.1_37622001_1 - 0.0018 17.3 18.9 0.0025 16.8 18.9 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253433.1_37622001_1 - 4.2e-36 124.8 5.4 5.9e-36 124.3 5.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253433.1_37622001_1 - 6.5e-10 38.5 6.4 8.8e-10 38.0 6.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253436.1_37622001_1 - 1.3e-38 133.0 18.0 1.8e-38 132.6 18.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253436.1_37622001_1 - 6.3e-13 48.4 21.9 7.4e-13 48.1 21.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MMPL PF03176.13 001253436.1_37622001_1 - 0.26 10.0 2.5 0.36 9.6 0.5 2.0 2 0 0 2 2 2 0 MMPL family 7tm_1 PF00001.19 001253436.1_37622001_1 - 0.42 9.7 13.1 0.58 9.2 13.1 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253437.1_37622001_1 - 4.6e-43 147.6 14.8 5.8e-43 147.3 14.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253437.1_37622001_1 - 2.2e-15 56.4 17.4 2.8e-15 56.1 17.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253437.1_37622001_1 - 7.7e-05 21.9 10.9 0.0001 21.5 10.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GP4 PF03010.12 001253437.1_37622001_1 - 0.0028 17.5 0.0 0.0057 16.5 0.0 1.5 1 0 0 1 1 1 1 GP4 V1R PF03402.12 001253438.1_37622001_1 - 2.4e-37 128.9 5.2 3.3e-37 128.4 5.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253438.1_37622001_1 - 1e-08 34.6 6.4 1.3e-08 34.2 6.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253438.1_37622001_1 - 1.3 8.0 8.9 2.1 7.4 8.9 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253439.1_37622001_1 - 4.4e-40 137.8 11.3 5.7e-40 137.5 11.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253439.1_37622001_1 - 8.7e-12 44.6 10.6 1.2e-11 44.2 10.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253440.1_37622001_1 - 6.8e-41 140.5 8.6 6.8e-41 140.5 8.6 1.2 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253440.1_37622001_1 - 2.9e-05 23.2 16.2 8.4e-05 21.7 16.2 1.6 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253440.1_37622001_1 - 2 7.4 9.8 2.8 6.9 9.3 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253441.1_37622001_1 - 1.6e-42 145.8 18.2 2.2e-42 145.4 18.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001253441.1_37622001_1 - 0.54 9.3 20.9 0.7 8.9 20.4 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253443.1_37623001_1 - 6.5e-35 120.9 15.4 8.4e-35 120.5 15.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253443.1_37623001_1 - 1.3e-07 30.9 17.9 1.7e-07 30.6 17.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253444.1_37622001_1 - 1e-44 153.0 16.8 1.3e-44 152.7 16.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253444.1_37622001_1 - 6.6e-10 38.4 19.9 7.2e-10 38.3 19.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253444.1_37622001_1 - 0.00075 18.7 13.6 0.0011 18.1 13.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253445.1_37622001_1 - 4.2e-47 160.9 14.3 5e-47 160.6 14.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253445.1_37622001_1 - 2.2e-12 46.6 14.0 3e-12 46.1 14.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253446.1_37622001_1 - 1.5e-33 116.4 15.8 1.8e-33 116.1 15.6 1.2 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253446.1_37622001_1 - 1.2e-16 60.6 19.7 1.5e-16 60.3 19.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253447.1_37622001_1 - 5.3e-34 117.9 14.7 7.1e-34 117.5 14.7 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253447.1_37622001_1 - 6e-14 51.7 17.9 8.6e-14 51.2 17.9 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253447.1_37622001_1 - 0.00071 18.8 14.1 0.001 18.2 14.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253448.1_37622001_1 - 1.2e-35 123.3 5.6 1.6e-35 122.9 5.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253448.1_37622001_1 - 9.5e-18 64.2 9.0 1.2e-17 63.9 9.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253448.1_37622001_1 - 1.6e-06 27.4 8.0 2.7e-06 26.7 7.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF872 PF05915.10 001253448.1_37622001_1 - 2.8 8.1 8.2 41 4.3 0.1 3.6 2 1 1 4 4 4 0 Eukaryotic protein of unknown function (DUF872) V1R PF03402.12 001253450.1_37622001_1 - 2.3e-39 135.5 8.4 3e-39 135.1 8.4 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253450.1_37622001_1 - 1.3e-05 24.4 11.7 0.00084 18.4 2.4 2.1 2 0 0 2 2 2 2 Taste receptor protein (TAS2R) V_ATPase_I PF01496.17 001253450.1_37622001_1 - 0.15 9.7 0.2 0.19 9.4 0.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NADHdh-2_N PF12155.6 001253450.1_37622001_1 - 1.7 8.9 7.7 0.5 10.7 0.3 3.0 3 0 0 3 3 3 0 NADH dehydrogenase subunit 2 N-terminal V1R PF03402.12 001253451.1_37622001_1 - 5.6e-37 127.7 16.3 7.3e-37 127.3 16.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253451.1_37622001_1 - 4.3e-13 48.9 18.5 5.4e-13 48.6 18.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253451.1_37622001_1 - 0.00034 19.8 8.9 0.00048 19.3 8.7 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GP4 PF03010.12 001253451.1_37622001_1 - 0.027 14.2 0.1 0.053 13.3 0.1 1.4 1 0 0 1 1 1 0 GP4 MMPL PF03176.13 001253451.1_37622001_1 - 0.032 13.0 0.1 0.032 13.0 0.1 1.7 2 0 0 2 2 2 0 MMPL family V1R PF03402.12 001253452.1_37622001_1 - 2.2e-37 129.0 6.8 2.2e-37 129.0 6.8 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253452.1_37622001_1 - 0.0021 17.1 14.0 0.0054 15.7 14.0 1.6 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253452.1_37622001_1 - 0.044 12.9 7.2 0.022 13.9 5.2 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253453.1_37622001_1 - 6e-46 157.1 16.6 8.2e-46 156.6 16.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253453.1_37622001_1 - 2.1e-09 36.8 23.1 2.5e-09 36.6 23.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253453.1_37622001_1 - 0.0012 18.0 19.5 0.002 17.3 19.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Chi-conotoxin PF16981.3 001253453.1_37622001_1 - 6 7.1 7.9 18 5.5 0.1 3.5 3 0 0 3 3 3 0 chi-Conotoxin or t superfamily V1R PF03402.12 001253456.1_37622001_1 - 1.6e-37 129.5 16.2 2e-37 129.2 16.2 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253456.1_37622001_1 - 3.4e-12 46.0 14.2 4.6e-12 45.5 14.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253457.1_37622001_1 - 1.5e-38 132.8 11.6 1.9e-38 132.5 11.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253457.1_37622001_1 - 6.6e-11 41.7 14.2 9.9e-11 41.2 14.2 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253457.1_37622001_1 - 0.058 12.5 11.0 0.088 11.9 11.0 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253458.1_37623001_1 - 2.5e-43 148.5 16.6 3.4e-43 148.1 16.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253458.1_37623001_1 - 2.3e-10 39.9 21.0 3e-10 39.6 21.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253458.1_37623001_1 - 5.6e-05 22.4 19.9 5.6e-05 22.4 19.9 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253459.1_37622001_1 - 9.1e-40 136.8 16.8 1.3e-39 136.3 16.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253459.1_37622001_1 - 1.2e-11 44.1 19.8 1.5e-11 43.9 19.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) AdHead_fibreRBD PF16812.3 001253459.1_37622001_1 - 0.018 14.7 0.1 0.03 14.0 0.1 1.3 1 0 0 1 1 1 0 C-terminal head domain of the fowl adenovirus type 1 long fibre 7tm_1 PF00001.19 001253459.1_37622001_1 - 0.11 11.5 18.1 0.78 8.8 18.1 2.0 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF3810 PF12725.5 001253459.1_37622001_1 - 0.13 11.4 4.7 2.3 7.4 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) V1R PF03402.12 001253461.1_37622001_1 - 5.5e-43 147.3 13.0 7e-43 147.0 13.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253461.1_37622001_1 - 3.9e-11 42.5 16.3 4.9e-11 42.2 16.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253461.1_37622001_1 - 0.00039 19.6 11.0 0.0005 19.3 11.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Chaperone_III PF07824.10 001253461.1_37622001_1 - 0.11 12.6 0.1 0.22 11.6 0.1 1.5 1 0 0 1 1 1 0 Type III secretion chaperone domain V1R PF03402.12 001253464.1_37623001_1 - 5e-31 108.1 11.8 6.7e-31 107.7 11.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253464.1_37623001_1 - 8e-08 31.6 14.0 1.1e-07 31.2 14.0 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253465.1_37622001_1 - 1.1e-39 136.5 9.8 1.5e-39 136.1 9.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253465.1_37622001_1 - 2.3e-07 30.1 11.4 4e-07 29.3 11.4 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253465.1_37622001_1 - 0.094 11.8 7.3 0.13 11.4 6.9 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253467.1_37622001_1 - 1e-39 136.6 11.4 1.3e-39 136.3 11.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253467.1_37622001_1 - 1.8e-08 33.7 14.0 2.9e-08 33.0 14.0 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253468.1_37622001_1 - 2.4e-32 112.5 20.3 3.1e-32 112.1 20.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253468.1_37622001_1 - 3.3e-05 23.0 26.2 4.3e-05 22.7 26.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253470.1_37622001_1 - 4.1e-37 128.1 9.5 5.1e-37 127.8 9.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253470.1_37622001_1 - 0.00011 21.2 14.5 0.00091 18.3 14.5 1.9 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253470.1_37622001_1 - 0.029 13.5 4.0 0.039 13.0 3.9 1.3 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253471.1_37622001_1 - 1.7e-26 93.3 15.9 3.5e-26 92.3 12.5 2.6 1 1 1 2 2 2 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253471.1_37622001_1 - 1.2e-05 24.5 8.3 1.2e-05 24.5 8.3 1.7 2 0 0 2 2 2 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253471.1_37622001_1 - 0.31 10.1 16.5 0.028 13.5 11.6 1.7 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253472.1_37622001_1 - 8.8e-37 127.0 14.9 1.2e-36 126.6 14.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253472.1_37622001_1 - 4.1e-12 45.7 18.9 5e-12 45.4 18.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF5134 PF17197.2 001253472.1_37622001_1 - 0.011 15.6 0.4 0.019 14.7 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5134) 7tm_1 PF00001.19 001253472.1_37622001_1 - 0.017 14.2 15.3 0.025 13.7 15.3 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253474.1_37622001_1 - 4.9e-37 127.8 16.0 6.8e-37 127.4 16.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253474.1_37622001_1 - 4.2e-11 42.4 20.3 5e-11 42.1 20.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) EPV_E5 PF08135.9 001253474.1_37622001_1 - 3.3 8.0 9.9 18 5.7 9.9 2.3 1 0 0 1 1 1 0 Major transforming protein E5 family V1R PF03402.12 001253475.1_37622001_1 - 3.7e-40 138.1 6.0 5e-40 137.7 6.0 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253475.1_37622001_1 - 0.0063 15.5 13.8 0.077 12.0 13.8 2.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253477.1_37622001_1 - 8.6e-42 143.4 7.0 1.2e-41 143.0 7.0 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253477.1_37622001_1 - 1.4e-05 24.2 13.7 6.8e-05 22.0 13.7 1.8 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253478.1_37622001_1 - 4.8e-40 137.7 12.5 6.1e-40 137.4 12.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253478.1_37622001_1 - 1.9e-10 40.2 16.0 2.5e-10 39.8 16.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253478.1_37622001_1 - 0.00088 18.4 9.9 0.0011 18.1 9.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Chaperone_III PF07824.10 001253478.1_37622001_1 - 0.1 12.7 0.2 0.21 11.7 0.2 1.5 1 0 0 1 1 1 0 Type III secretion chaperone domain V1R PF03402.12 001253479.1_37622001_1 - 4.9e-30 104.9 19.5 6.1e-30 104.6 19.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253479.1_37622001_1 - 2.3e-06 26.8 23.1 2.9e-06 26.5 23.1 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253479.1_37622001_1 - 0.39 9.8 17.9 0.54 9.3 17.9 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253480.1_37622001_1 - 5.7e-46 157.1 19.4 7.3e-46 156.8 19.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253480.1_37622001_1 - 1.3e-11 44.1 23.7 1.5e-11 43.8 23.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253480.1_37622001_1 - 0.00013 21.2 18.1 0.00018 20.7 18.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253481.1_37622001_1 - 8.9e-40 136.8 12.3 1.2e-39 136.5 12.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253481.1_37622001_1 - 8e-13 48.0 15.2 9.9e-13 47.7 15.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253481.1_37622001_1 - 0.01 14.9 10.9 0.015 14.4 10.9 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253483.1_37622001_1 - 2.6e-33 115.7 13.7 4.2e-33 115.0 13.7 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253483.1_37622001_1 - 0.0045 16.0 19.3 0.0065 15.5 19.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253484.1_37622001_1 - 1.3e-41 142.8 16.2 1.6e-41 142.6 16.2 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253484.1_37622001_1 - 2.9e-10 39.6 19.1 3.7e-10 39.3 19.1 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253484.1_37622001_1 - 0.0062 15.7 17.1 0.0091 15.1 16.8 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253485.1_37622001_1 - 4.7e-35 121.4 18.4 5.5e-35 121.1 18.4 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253485.1_37622001_1 - 2e-09 36.9 17.5 2.6e-09 36.5 17.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253486.1_37622001_1 - 7.5e-40 137.1 11.6 1.1e-39 136.6 11.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253486.1_37622001_1 - 9.2e-10 38.0 13.1 1.3e-09 37.5 13.1 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253486.1_37622001_1 - 0.18 10.9 16.6 0.37 9.8 16.6 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253489.1_37622001_1 - 6e-32 111.2 12.8 7.8e-32 110.8 12.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253489.1_37622001_1 - 1.8e-15 56.7 13.6 2.5e-15 56.3 13.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253489.1_37622001_1 - 0.077 12.1 8.5 0.15 11.2 8.5 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253490.1_37623001_1 - 4.5e-41 141.1 10.6 5.9e-41 140.7 10.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253490.1_37623001_1 - 1e-10 41.1 16.7 1.2e-10 40.8 16.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253492.1_37622001_1 - 1.4e-38 132.9 7.3 1.4e-38 132.9 7.3 1.2 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253492.1_37622001_1 - 0.00076 18.5 14.1 0.0018 17.3 14.1 1.5 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253492.1_37622001_1 - 0.045 12.9 8.0 0.062 12.4 7.7 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253493.1_37622001_1 - 7e-43 147.0 14.6 9.1e-43 146.6 14.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253493.1_37622001_1 - 2.5e-11 43.1 16.8 3.1e-11 42.8 16.8 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253493.1_37622001_1 - 1.6e-06 27.5 18.3 2.2e-06 27.0 18.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ndc1_Nup PF09531.8 001253493.1_37622001_1 - 4.9 5.6 17.4 1.1 7.7 4.3 2.1 1 1 1 2 2 2 0 Nucleoporin protein Ndc1-Nup ECF_trnsprt PF12822.5 001253493.1_37622001_1 - 8.5 6.3 12.3 15 5.4 4.5 2.4 2 1 0 2 2 2 0 ECF transporter, substrate-specific component V1R PF03402.12 001253494.1_37623001_1 - 2.3e-37 129.0 2.2 3e-37 128.6 2.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253494.1_37623001_1 - 1.4e-10 40.7 2.9 2.9e-10 39.6 2.9 1.5 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253494.1_37623001_1 - 0.0013 17.9 2.1 0.0016 17.6 1.4 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253495.1_37622001_1 - 9.5e-36 123.6 13.4 1.2e-35 123.3 13.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253495.1_37622001_1 - 2.5e-09 36.6 14.0 3.1e-09 36.2 14.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253496.1_37622001_1 - 7.6e-35 120.7 14.4 9.4e-35 120.4 14.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253496.1_37622001_1 - 3e-08 33.0 15.4 3.7e-08 32.7 15.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253497.1_37622001_1 - 5.6e-39 134.2 13.3 7.2e-39 133.9 13.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253497.1_37622001_1 - 3.9e-12 45.7 18.5 5.2e-12 45.4 18.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253497.1_37622001_1 - 0.024 13.7 11.7 0.036 13.2 11.7 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253498.1_37622001_1 - 6e-39 134.1 12.4 7.9e-39 133.7 12.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253498.1_37622001_1 - 4e-12 45.7 15.4 5.1e-12 45.4 15.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253498.1_37622001_1 - 0.0043 16.2 11.3 0.0058 15.8 11.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253499.1_37622001_1 - 4e-34 118.3 15.2 5.4e-34 117.9 15.2 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253499.1_37622001_1 - 1e-13 51.0 19.5 1.4e-13 50.5 19.5 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253499.1_37622001_1 - 0.0017 17.6 15.1 0.0024 17.0 15.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253500.1_37622001_1 - 2.3e-36 125.6 12.4 3e-36 125.3 12.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253500.1_37622001_1 - 1.4e-11 43.9 14.7 1.7e-11 43.6 14.7 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253500.1_37622001_1 - 0.41 9.7 14.0 1.2 8.2 14.0 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253501.1_37622001_1 - 1.9e-41 142.3 16.6 2.3e-41 142.1 16.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253501.1_37622001_1 - 2.5e-10 39.8 17.4 3.2e-10 39.5 17.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253501.1_37622001_1 - 0.017 14.2 16.0 0.02 14.0 15.4 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253502.1_37622001_1 - 1e-41 143.2 13.2 1.4e-41 142.8 13.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253502.1_37622001_1 - 2e-14 53.3 14.9 2.3e-14 53.1 14.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253502.1_37622001_1 - 0.0085 15.2 11.1 0.012 14.7 11.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253503.1_37622001_1 - 1.8e-38 132.6 16.4 2.2e-38 132.3 16.4 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253503.1_37622001_1 - 4.6e-16 58.7 19.1 5.6e-16 58.4 19.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253503.1_37622001_1 - 0.083 12.0 13.3 0.13 11.4 13.3 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253504.1_37622001_1 - 1.8e-35 122.7 18.0 2.4e-35 122.3 18.0 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R V1R PF03402.12 001253506.1_37622001_1 - 2.4e-43 148.5 16.6 3.2e-43 148.1 16.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253506.1_37622001_1 - 4.7e-12 45.5 20.3 5.6e-12 45.2 20.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253506.1_37622001_1 - 2.7e-05 23.4 21.3 5.4e-05 22.4 21.3 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253507.1_37622001_1 - 1.5e-36 126.2 18.0 2.1e-36 125.8 18.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253507.1_37622001_1 - 4.9e-13 48.7 22.1 6e-13 48.4 22.1 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253507.1_37622001_1 - 0.041 13.0 12.2 0.057 12.5 12.0 1.3 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253508.1_37622001_1 - 6.6e-41 140.5 11.9 8.4e-41 140.2 11.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253508.1_37622001_1 - 5.7e-07 28.8 16.9 7.7e-07 28.4 16.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253508.1_37622001_1 - 0.009 15.1 10.2 0.012 14.7 10.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4328 PF14219.4 001253508.1_37622001_1 - 0.068 12.6 1.0 0.2 11.0 0.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4328) V1R PF03402.12 001253511.1_37622001_1 - 1.7e-35 122.8 9.3 2.2e-35 122.4 9.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253511.1_37622001_1 - 8.1e-12 44.7 8.4 1.2e-11 44.1 8.4 1.3 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253511.1_37622001_1 - 3.3e-05 23.1 6.7 3.3e-05 23.1 6.7 1.5 1 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) MDMPI_C PF07398.9 001253511.1_37622001_1 - 0.032 15.0 0.0 0.068 13.9 0.0 1.5 1 0 0 1 1 1 0 MDMPI C-terminal domain WD40 PF00400.30 001253511.1_37622001_1 - 0.033 14.9 0.2 0.089 13.6 0.2 1.7 1 0 0 1 1 1 0 WD domain, G-beta repeat MMPL PF03176.13 001253511.1_37622001_1 - 0.036 12.9 0.1 0.036 12.9 0.1 1.9 2 0 0 2 2 2 0 MMPL family V1R PF03402.12 001253512.1_37622001_1 - 6.4e-39 134.0 11.8 6.4e-39 134.0 11.8 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253512.1_37622001_1 - 2.7e-10 39.7 10.5 3.3e-10 39.4 10.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MMPL PF03176.13 001253512.1_37622001_1 - 0.007 15.2 0.4 0.007 15.2 0.4 1.9 2 0 0 2 2 2 1 MMPL family V1R PF03402.12 001253513.1_37622001_1 - 2.3e-38 132.2 13.0 3e-38 131.8 13.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253513.1_37622001_1 - 4.4e-10 39.0 13.6 6.1e-10 38.6 13.6 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253513.1_37622001_1 - 0.008 15.3 12.7 0.017 14.3 12.9 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MMPL PF03176.13 001253513.1_37622001_1 - 0.011 14.6 0.2 0.011 14.6 0.2 2.3 3 0 0 3 3 3 0 MMPL family V1R PF03402.12 001253515.1_37623001_1 - 3.2e-47 161.3 20.0 4.2e-47 160.9 20.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253515.1_37623001_1 - 2.5e-12 46.4 24.2 3e-12 46.1 24.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253515.1_37623001_1 - 0.00017 20.8 25.6 0.00027 20.1 25.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF5134 PF17197.2 001253515.1_37623001_1 - 0.019 14.8 0.1 0.052 13.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5134) STE3 PF02076.13 001253515.1_37623001_1 - 0.046 12.8 17.9 0.081 12.0 9.6 2.2 2 0 0 2 2 2 0 Pheromone A receptor Delta_lysin PF05372.9 001253515.1_37623001_2 - 0.25 10.6 0.3 0.39 9.9 0.3 1.3 1 0 0 1 1 1 0 Delta lysin family V1R PF03402.12 001253516.1_37622001_1 - 1.3e-37 129.7 12.2 1.6e-37 129.4 12.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253516.1_37622001_1 - 1e-11 44.4 16.2 1.3e-11 44.1 16.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MMPL PF03176.13 001253516.1_37622001_1 - 0.1 11.3 0.8 0.13 11.0 0.1 1.5 2 0 0 2 2 2 0 MMPL family V1R PF03402.12 001253518.1_37622001_1 - 8.3e-45 153.3 16.3 1.1e-44 153.0 16.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253518.1_37622001_1 - 8.8e-11 41.3 18.5 1.1e-10 41.0 18.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253518.1_37622001_1 - 3.5e-07 29.6 19.0 4.4e-07 29.3 19.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ECF_trnsprt PF12822.5 001253518.1_37622001_1 - 0.2 11.6 13.6 0.12 12.3 0.4 2.8 2 1 0 2 2 2 0 ECF transporter, substrate-specific component DUF808 PF05661.10 001253518.1_37622001_1 - 0.46 9.4 3.1 0.4 9.6 0.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF808) Pacs-1 PF10254.7 001143870.1_06527001_2 - 7.2e-188 624.6 0.0 7.2e-188 624.6 0.0 2.5 4 0 0 4 4 4 1 PACS-1 cytosolic sorting protein DUF3712 PF12505.6 001143870.1_06527001_2 - 0.049 13.7 0.1 0.12 12.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3712) V1R PF03402.12 001253519.1_37622001_1 - 8.6e-40 136.9 17.5 1.1e-39 136.5 17.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253519.1_37622001_1 - 9e-08 31.4 15.1 1.2e-07 31.0 15.1 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253519.1_37622001_1 - 0.031 13.4 15.5 0.046 12.8 15.5 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253520.1_37622001_1 - 3.1e-40 138.3 12.4 3.9e-40 138.0 12.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253520.1_37622001_1 - 2.4e-11 43.2 13.4 2.8e-11 43.0 13.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253520.1_37622001_1 - 0.0025 17.0 8.9 0.0025 17.0 8.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1049 PF06305.9 001253520.1_37622001_1 - 6.8 6.5 6.5 0.84 9.4 0.6 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1049) V1R PF03402.12 001253522.1_37622001_1 - 3.4e-41 141.5 15.6 4.5e-41 141.1 15.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253522.1_37622001_1 - 3.6e-11 42.6 20.2 4.3e-11 42.4 20.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253522.1_37622001_1 - 0.63 9.1 12.7 0.93 8.5 12.7 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253523.1_37622001_1 - 3.6e-37 128.3 12.4 4.9e-37 127.9 12.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253523.1_37622001_1 - 1.4e-16 60.4 12.9 1.6e-16 60.1 12.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253523.1_37622001_1 - 5e-05 22.5 9.2 7.2e-05 22.0 9.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253524.1_37622001_1 - 1.1e-41 143.0 15.5 1.5e-41 142.7 15.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253524.1_37622001_1 - 1.1e-11 44.3 17.9 1.3e-11 44.0 17.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253525.1_37622001_1 - 1.1e-43 149.6 17.2 1.3e-43 149.4 17.2 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253525.1_37622001_1 - 6.8e-08 31.8 20.7 8.8e-08 31.5 20.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253527.1_37622001_1 - 7.9e-38 130.5 15.2 1.1e-37 130.0 15.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253527.1_37622001_1 - 8.7e-11 41.3 19.7 1e-10 41.1 19.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) EPV_E5 PF08135.9 001253527.1_37622001_1 - 3.3 8.0 9.9 18 5.7 9.9 2.3 1 0 0 1 1 1 0 Major transforming protein E5 family V1R PF03402.12 001253528.1_37622001_1 - 2.2e-22 79.8 13.2 5.5e-21 75.2 13.2 2.1 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253528.1_37622001_1 - 0.0018 17.3 19.4 0.005 15.9 19.4 1.7 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) Peptidase_C21 PF05381.10 001253528.1_37622001_1 - 0.062 13.5 0.2 9.6 6.5 0.0 2.6 2 0 0 2 2 2 0 Tymovirus endopeptidase V1R PF03402.12 001253529.1_37622001_1 - 6e-33 114.4 22.9 8.1e-33 114.0 22.9 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253529.1_37622001_1 - 2.5e-11 43.1 28.6 6.3e-11 41.8 29.0 1.4 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253530.1_37622001_1 - 1.1e-50 172.6 17.0 1.3e-50 172.4 17.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253530.1_37622001_1 - 1.1e-09 37.7 19.9 1.3e-09 37.5 19.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253530.1_37622001_1 - 0.026 13.6 15.8 0.031 13.4 15.4 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF996 PF06195.11 001253530.1_37622001_1 - 3.7 7.7 9.4 0.13 12.4 0.3 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF996) V1R PF03402.12 001253531.1_37622001_1 - 1.2e-43 149.5 17.2 1.5e-43 149.2 17.2 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253531.1_37622001_1 - 2e-10 40.2 19.2 2.7e-10 39.7 19.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253531.1_37622001_1 - 0.027 13.6 19.4 0.043 12.9 18.5 1.7 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253532.1_37622001_1 - 2.9e-40 138.4 12.1 3.8e-40 138.1 12.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253532.1_37622001_1 - 5.5e-13 48.6 13.9 7.2e-13 48.2 13.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253534.1_37622001_1 - 5.2e-37 127.8 15.7 7.2e-37 127.3 15.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253534.1_37622001_1 - 2.5e-09 36.5 18.4 3e-09 36.3 18.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253534.1_37622001_1 - 5.4e-05 22.4 19.7 7.7e-05 21.9 19.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Plasmid_stab_B PF10784.7 001253534.1_37622001_1 - 0.027 14.2 0.0 0.064 13.0 0.0 1.6 1 0 0 1 1 1 0 Plasmid stability protein DUF3810 PF12725.5 001253534.1_37622001_1 - 0.72 9.0 3.6 1.3 8.2 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) 7tm_1 PF00001.19 001206565.1_06523001_1 - 2.4e-54 184.2 18.0 3.2e-54 183.8 18.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001206565.1_06523001_1 - 2.5e-13 49.9 20.4 3.1e-13 49.6 20.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001206565.1_06523001_1 - 0.057 13.0 13.9 0.022 14.3 9.2 2.2 2 1 0 2 2 2 0 Olfactory receptor V1R PF03402.12 001253536.1_37622001_1 - 2.5e-40 138.6 11.9 3e-40 138.4 11.9 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253536.1_37622001_1 - 2.4e-12 46.4 10.0 3.2e-12 46.1 10.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253537.1_37622001_1 - 2.7e-38 132.0 8.3 2.7e-38 132.0 8.3 1.2 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253537.1_37622001_1 - 4.4e-06 25.9 14.7 7e-06 25.2 14.7 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253537.1_37622001_1 - 0.27 10.3 9.6 0.42 9.7 9.3 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253538.1_37622001_1 - 9.1e-51 172.9 13.5 1.1e-50 172.6 13.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253538.1_37622001_1 - 7.6e-11 41.5 16.2 9.1e-11 41.3 16.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253538.1_37622001_1 - 0.0068 15.5 13.7 0.0092 15.1 13.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) HEV_ORF1 PF02444.14 001253538.1_37622001_1 - 0.091 13.2 1.2 1.1 9.7 0.2 2.5 2 0 0 2 2 2 0 Hepatitis E virus ORF-2 (Putative capsid protein) DUF996 PF06195.11 001253538.1_37622001_1 - 2.5 8.3 7.3 0.78 9.9 2.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF996) V1R PF03402.12 001253539.1_37622001_1 - 6.3e-39 134.1 19.7 8.1e-39 133.7 19.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253539.1_37622001_1 - 1.5e-08 34.0 24.7 1.8e-08 33.7 24.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253539.1_37622001_1 - 0.021 14.0 15.7 0.026 13.6 15.0 1.6 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) Cation_ATPase_C PF00689.19 001253539.1_37622001_1 - 0.14 11.7 13.3 0.097 12.2 0.9 2.6 2 1 0 2 2 2 0 Cation transporting ATPase, C-terminus V1R PF03402.12 001253540.1_37622001_1 - 1.5e-46 159.0 15.5 1.8e-46 158.8 15.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253540.1_37622001_1 - 1.3e-13 50.6 17.4 1.7e-13 50.2 17.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) RAMP4 PF06624.10 001253540.1_37622001_1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Ribosome associated membrane protein RAMP4 V1R PF03402.12 001253541.1_37622001_1 - 1.3e-39 136.3 16.0 1.7e-39 135.9 16.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253541.1_37622001_1 - 9.5e-14 51.1 19.7 1.2e-13 50.7 19.7 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253542.1_37622001_1 - 1.1e-34 120.1 13.7 1.5e-34 119.7 13.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253542.1_37622001_1 - 2.1e-11 43.4 18.4 2.7e-11 43.0 18.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253543.1_37622001_1 - 4.4e-35 121.5 14.3 5.4e-35 121.2 14.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253543.1_37622001_1 - 5.5e-11 42.0 15.8 7.8e-11 41.5 15.8 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253543.1_37622001_1 - 0.02 14.0 12.6 0.027 13.6 12.6 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253545.1_37622001_1 - 8.3e-44 150.1 16.2 9.7e-44 149.8 16.2 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253545.1_37622001_1 - 2.2e-11 43.3 16.7 2.8e-11 42.9 16.7 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253545.1_37622001_1 - 0.089 11.9 16.1 0.12 11.5 15.5 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253546.1_37622001_1 - 2.8e-35 122.1 13.9 3.5e-35 121.8 13.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253546.1_37622001_1 - 2.7e-10 39.7 17.3 3.5e-10 39.3 17.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253546.1_37622001_1 - 0.42 9.7 15.6 0.78 8.8 15.6 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253547.1_37622001_1 - 8.9e-36 123.7 10.0 1.1e-35 123.4 10.0 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253547.1_37622001_1 - 3.1e-14 52.6 10.2 3.9e-14 52.3 10.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MMPL PF03176.13 001253547.1_37622001_1 - 0.055 12.3 0.6 0.089 11.6 0.6 1.4 1 0 0 1 1 1 0 MMPL family 7tm_1 PF00001.19 001253547.1_37622001_1 - 0.56 9.3 9.3 0.7 8.9 9.3 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253548.1_37622001_1 - 9.8e-36 123.6 4.1 1.2e-35 123.2 4.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253548.1_37622001_1 - 5.8e-10 38.6 7.1 7.4e-10 38.3 7.1 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) SCAMP PF04144.11 001253548.1_37622001_1 - 2.8 8.1 9.4 1.4 9.1 5.1 2.7 2 1 0 2 2 2 0 SCAMP family V1R PF03402.12 001253549.1_37622001_1 - 6e-46 157.1 14.3 7.2e-46 156.8 14.3 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253549.1_37622001_1 - 6.5e-11 41.8 13.2 8.4e-11 41.4 13.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253549.1_37622001_1 - 0.0023 17.1 15.1 0.0026 16.9 14.2 1.6 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253550.1_37622001_1 - 2e-42 145.5 14.4 2.7e-42 145.1 14.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253550.1_37622001_1 - 4.9e-10 38.9 16.2 6.4e-10 38.5 16.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) STE3 PF02076.13 001253550.1_37622001_1 - 0.33 10.0 13.8 0.021 13.9 5.1 2.8 1 1 2 3 3 3 0 Pheromone A receptor DUF443 PF04276.10 001253550.1_37622001_1 - 7.3 6.2 9.3 0.2 11.3 1.5 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF443) V1R PF03402.12 001253551.1_37622001_1 - 2.3e-43 148.6 14.4 2.3e-43 148.6 14.4 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253551.1_37622001_1 - 1e-09 37.8 24.2 1.3e-09 37.5 24.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253551.1_37622001_1 - 3.6e-06 26.3 18.3 5.2e-06 25.8 18.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253552.1_37622001_1 - 2.4e-38 132.2 10.9 3e-38 131.8 10.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253552.1_37622001_1 - 7e-10 38.4 10.9 8.8e-10 38.0 10.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253552.1_37622001_1 - 0.025 13.7 6.0 0.035 13.2 6.0 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) MMPL PF03176.13 001253552.1_37622001_1 - 0.14 10.9 2.5 0.066 12.0 0.2 1.6 2 0 0 2 2 2 0 MMPL family DUF872 PF05915.10 001253552.1_37622001_1 - 2.6 8.2 5.3 3.5 7.8 0.2 3.0 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF872) V1R PF03402.12 001253553.1_37622001_1 - 7.3e-42 143.7 16.3 9.5e-42 143.3 16.3 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253553.1_37622001_1 - 2.2e-09 36.7 22.3 2.7e-09 36.4 22.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253553.1_37622001_1 - 0.042 12.9 22.1 0.053 12.6 22.1 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) SecG PF03840.12 001253553.1_37622001_1 - 3.9 7.5 10.8 0.45 10.5 1.5 2.9 3 0 0 3 3 3 0 Preprotein translocase SecG subunit V1R PF03402.12 001253554.1_37622001_1 - 1.9e-44 152.1 17.1 2.6e-44 151.7 17.1 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253554.1_37622001_1 - 7.2e-08 31.7 24.0 8.6e-08 31.5 24.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253554.1_37622001_1 - 0.0086 15.2 19.2 0.015 14.4 19.2 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Chi-conotoxin PF16981.3 001253554.1_37622001_1 - 6.7 6.9 8.7 14 5.9 0.1 3.5 3 0 0 3 3 3 0 chi-Conotoxin or t superfamily V1R PF03402.12 001253555.1_37622001_1 - 3.4e-46 157.9 10.1 4.5e-46 157.5 10.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253555.1_37622001_1 - 5.5e-09 35.4 16.2 6.6e-09 35.2 16.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Mntp PF02659.13 001253555.1_37622001_1 - 0.00031 20.4 0.4 0.0007 19.2 0.4 1.7 1 0 0 1 1 1 1 Putative manganese efflux pump V1R PF03402.12 001253556.1_37622001_1 - 5.5e-51 173.6 11.1 7.7e-51 173.1 11.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253556.1_37622001_1 - 5e-10 38.8 17.9 5.9e-10 38.6 17.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253556.1_37622001_1 - 0.0022 17.1 21.0 0.0033 16.6 21.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253559.1_37622001_1 - 4.9e-41 141.0 12.7 4.9e-41 141.0 12.7 1.4 1 1 1 2 2 2 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253559.1_37622001_1 - 2.3e-10 40.0 15.8 3.2e-10 39.5 15.8 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253559.1_37622001_1 - 0.00035 19.8 10.7 0.00045 19.4 10.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PTS_EIIC PF02378.16 001253559.1_37622001_1 - 0.0062 15.5 0.0 0.012 14.6 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase system, EIIC V1R PF03402.12 001253561.1_37622001_1 - 1.9e-50 171.8 13.9 2.3e-50 171.6 13.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253561.1_37622001_1 - 1.6e-10 40.4 17.1 2e-10 40.2 17.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253561.1_37622001_1 - 0.12 11.4 14.5 0.17 11.0 14.2 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF996 PF06195.11 001253561.1_37622001_1 - 5.8 7.1 9.8 0.21 11.7 0.6 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF996) V1R PF03402.12 001253563.1_37622001_1 - 1.8e-34 119.4 16.6 2.4e-34 119.0 16.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253563.1_37622001_1 - 7.8e-11 41.5 20.1 9.3e-11 41.2 20.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253565.1_37622001_1 - 1.8e-39 135.9 12.5 2.2e-39 135.6 12.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253565.1_37622001_1 - 1.9e-13 50.1 15.2 2.6e-13 49.7 15.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253566.1_37622001_1 - 3.8e-36 124.9 12.7 5e-36 124.6 12.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253566.1_37622001_1 - 3.3e-07 29.6 18.4 4.6e-07 29.1 18.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253566.1_37622001_1 - 0.0018 17.4 7.4 0.0018 17.4 7.4 1.7 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001253567.1_37622001_1 - 7.4e-34 117.4 6.0 9.7e-34 117.1 6.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253567.1_37622001_1 - 3.7e-13 49.1 4.4 4.9e-13 48.7 4.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001253568.1_37622001_1 - 1.7e-39 135.9 11.9 1.7e-39 135.9 11.9 1.4 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001253568.1_37622001_1 - 2e-10 40.2 17.9 2.4e-10 39.9 17.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001253568.1_37622001_1 - 0.072 12.2 12.8 0.076 12.1 12.0 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Homeobox PF00046.27 001169065.1_40421001_1 - 1.8e-21 75.6 5.7 1.8e-21 75.6 5.7 1.5 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.9 001169065.1_40421001_1 - 0.012 15.4 0.2 0.022 14.5 0.2 1.5 1 0 0 1 1 1 0 Homeobox KN domain 7tm_4 PF13853.4 001168852.1_40422001_1 - 2.7e-112 375.0 27.1 3.1e-112 374.7 27.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168852.1_40422001_1 - 1.3e-20 73.6 22.7 5.7e-20 71.5 22.7 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168852.1_40422001_1 - 2.1e-06 27.2 20.6 9.7e-06 25.0 20.6 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001168853.1_40422001_1 - 2.1e-104 349.0 27.4 2.6e-104 348.7 27.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168853.1_40422001_1 - 1.3e-13 50.6 28.4 5.2e-13 48.7 25.6 2.3 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168853.1_40422001_1 - 7.7e-05 22.1 20.0 0.0034 16.6 20.0 2.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001168854.1_40422001_1 - 1e-110 369.7 24.8 1.3e-110 369.4 24.8 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168854.1_40422001_1 - 2.4e-24 85.9 22.6 6.9e-24 84.4 22.6 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168854.1_40422001_1 - 6.9e-07 28.8 22.5 3.6e-06 26.4 22.5 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001168855.1_40422001_1 - 4.6e-100 334.8 21.1 5.6e-100 334.5 21.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168855.1_40422001_1 - 6.4e-14 51.7 18.8 4.2e-13 49.0 18.8 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168855.1_40422001_1 - 2.5e-07 30.2 8.7 2.5e-07 30.2 8.7 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001168856.1_40422001_1 - 2.8e-141 470.0 21.8 3.2e-141 469.8 21.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168856.1_40422001_1 - 1.1e-18 67.3 17.1 4e-18 65.5 17.1 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168856.1_40422001_1 - 8.2e-08 31.8 11.6 1.2e-07 31.2 11.6 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001168856.1_40422001_1 - 0.00092 18.5 9.2 0.00092 18.5 9.2 2.2 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.7 001168856.1_40422001_1 - 0.0036 16.7 7.9 0.0036 16.7 7.9 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_4 PF13853.4 001168856.1_40422001_3 - 5.5e-07 29.5 0.1 7.3e-07 29.1 0.1 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_4 PF13853.4 001168857.1_40422001_1 - 5.9e-118 393.5 24.8 6.9e-118 393.3 24.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168857.1_40422001_1 - 4.3e-20 71.9 21.4 1.2e-19 70.5 21.4 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168857.1_40422001_1 - 6e-07 29.0 18.9 1.1e-06 28.1 18.9 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001168858.1_40422001_1 - 1.3e-82 277.6 20.6 1.5e-82 277.4 20.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168858.1_40422001_1 - 3.2e-09 36.3 20.9 8.7e-09 34.9 20.9 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ubiquitin PF00240.21 001168859.1_40424001_1 - 3e-18 65.2 0.3 5.4e-18 64.4 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.29 001168859.1_40424001_1 - 9.3e-07 28.5 1.3 1.6e-06 27.7 0.3 1.9 2 0 0 2 2 2 1 UBA/TS-N domain Rad60-SLD PF11976.6 001168859.1_40424001_1 - 4e-05 23.2 0.2 6.3e-05 22.6 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.4 001168859.1_40424001_1 - 0.0039 17.1 0.0 0.0098 15.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001168859.1_40424001_1 - 0.0074 16.7 0.0 0.018 15.4 0.0 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain YukD PF08817.8 001168859.1_40424001_1 - 0.012 16.1 0.0 0.033 14.7 0.0 1.8 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD HOIP-UBA PF16678.3 001168859.1_40424001_1 - 0.037 13.9 0.1 0.062 13.2 0.1 1.3 1 0 0 1 1 1 0 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase ExbD PF02472.14 001168859.1_40424001_1 - 0.05 13.6 0.0 0.094 12.8 0.0 1.3 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR PBP_N PF17093.3 001168859.1_40424001_1 - 4.7 7.3 7.7 0.6 10.2 1.7 2.5 2 0 0 2 2 2 0 Penicillin-binding protein N-terminus 7tm_4 PF13853.4 001168861.1_40423001_1 - 4.3e-97 325.1 23.6 6.1e-97 324.5 23.6 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168861.1_40423001_1 - 6.8e-21 74.6 25.5 1.7e-20 73.3 25.5 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168861.1_40423001_1 - 7e-06 25.5 17.9 1.1e-05 24.8 17.9 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001168863.1_40422001_1 - 3.6e-101 338.5 24.4 4.2e-101 338.2 24.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168863.1_40422001_1 - 3e-19 69.2 25.6 6.9e-19 68.0 25.6 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168863.1_40422001_1 - 2.2e-09 37.0 20.6 5e-09 35.8 20.6 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Fungal_trans_2 PF11951.6 001168863.1_40422001_1 - 0.014 14.1 0.2 0.02 13.6 0.2 1.1 1 0 0 1 1 1 0 Fungal specific transcription factor domain 7tm_4 PF13853.4 001168864.1_40421001_1 - 3.5e-44 151.5 8.3 3.9e-44 151.3 8.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168864.1_40421001_1 - 1.7e-07 30.7 8.4 2e-07 30.4 8.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Phage_holin_3_2 PF04550.10 001168864.1_40421001_1 - 0.012 15.9 0.1 0.022 15.0 0.1 1.5 1 1 0 1 1 1 0 Phage holin family 2 7TM_GPCR_Srsx PF10320.7 001168864.1_40421001_1 - 0.057 12.7 7.8 0.015 14.6 4.9 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.7 001168864.1_40421001_1 - 0.12 11.8 8.6 0.16 11.3 8.6 1.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_4 PF13853.4 001168867.1_40422001_1 - 7.5e-96 321.0 25.8 8.6e-96 320.8 25.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168867.1_40422001_1 - 3.4e-17 62.4 24.5 7e-17 61.4 24.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168867.1_40422001_1 - 9.6e-10 38.1 16.1 9.6e-10 38.1 16.1 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001168868.1_40422001_1 - 1.4e-65 221.7 14.7 1.6e-65 221.5 14.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168868.1_40422001_1 - 1.6e-13 50.4 13.0 1.9e-13 50.1 13.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168868.1_40422001_1 - 2.7e-09 36.7 16.2 3.4e-09 36.4 16.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx NHL PF01436.19 001168723.1_40421001_1 - 1.3e-11 43.8 0.0 0.00018 21.2 0.0 2.7 3 0 0 3 3 3 2 NHL repeat HORMA PF02301.16 001168894.1_40422001_1 - 3.6e-22 78.9 1.3 5.6e-22 78.3 1.3 1.3 1 0 0 1 1 1 1 HORMA domain ATG101 PF07855.10 001168894.1_40422001_1 - 2e-05 24.5 0.6 0.00047 20.0 0.6 2.3 1 1 0 1 1 1 1 Autophagy-related protein 101 IRF PF00605.15 001168757.1_40422001_1 - 3.7e-41 139.5 0.6 6e-41 138.8 0.6 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor UQ_con PF00179.24 001168908.1_40421001_1 - 2.1e-45 153.7 0.3 2.4e-45 153.5 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.11 001168908.1_40421001_1 - 1e-05 25.3 0.1 1.6e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 UEV domain Prok-E2_B PF14461.4 001168908.1_40421001_1 - 2.8e-05 23.7 0.0 3.3e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.20 001168908.1_40421001_1 - 4.9e-05 23.5 0.2 7.7e-05 22.8 0.2 1.5 1 1 0 1 1 1 1 RWD domain Histone PF00125.22 001168918.1_40421001_1 - 8.6e-55 184.6 1.7 9.5e-55 184.4 1.7 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.4 001168918.1_40421001_1 - 4.6e-05 23.3 0.2 8.9e-05 22.4 0.0 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.4 001168918.1_40421001_1 - 0.00026 21.2 0.0 0.00039 20.6 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.3 001168918.1_40421001_1 - 0.0049 17.3 1.4 0.007 16.8 1.4 1.2 1 0 0 1 1 1 1 PCNA-associated factor CBFD_NFYB_HMF PF00808.21 001168918.1_40421001_1 - 0.05 13.8 0.0 0.096 12.9 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone ASD2 PF08687.9 001168762.1_40426001_1 - 1e-75 255.0 0.4 1.2e-75 254.7 0.4 1.1 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 ASD1 PF08688.8 001168762.1_40426001_1 - 3.7e-15 56.5 0.0 8.1e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 Apx/Shroom domain ASD1 GTP_EFTU PF00009.25 001168941.1_40423001_1 - 1.7e-54 184.2 0.0 2.3e-54 183.7 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 001168941.1_40423001_1 - 6.1e-40 135.9 0.0 1.4e-39 134.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.23 001168941.1_40423001_1 - 3.9e-15 55.9 1.9 6.2e-15 55.2 0.7 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 001168941.1_40423001_1 - 0.00025 21.0 0.2 0.0067 16.4 0.2 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.4 001168941.1_40423001_1 - 0.0061 16.4 1.5 0.012 15.4 0.3 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 4 Dynamin_N PF00350.21 001168941.1_40423001_1 - 0.072 13.0 0.1 15 5.4 0.1 2.4 2 0 0 2 2 2 0 Dynamin family G-alpha PF00503.18 001168941.1_40423001_1 - 0.22 10.5 0.2 0.64 9.0 0.1 1.8 2 0 0 2 2 2 0 G-protein alpha subunit HLH PF00010.24 001168781.1_40422001_1 - 7.7e-13 48.1 0.4 2.2e-12 46.6 0.5 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF1283 PF06932.9 001168781.1_40422001_1 - 0.071 13.3 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1283) DUF3446 PF11928.6 001168781.1_40422001_1 - 0.11 12.6 6.9 0.2 11.8 6.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) Metal_resist PF13801.4 001168781.1_40422001_1 - 3.5 7.7 8.4 0.15 12.1 2.3 1.8 2 0 0 2 2 2 0 Heavy-metal resistance Ribosomal_S4e PF00900.18 001168790.1_40422001_1 - 2.8e-39 132.7 0.7 1.8e-38 130.2 0.4 2.0 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.3 001168790.1_40422001_1 - 3.7e-29 100.0 0.1 6.5e-29 99.2 0.1 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus KOW PF00467.27 001168790.1_40422001_1 - 4.9e-06 26.2 0.2 1.4e-05 24.7 0.2 1.8 1 0 0 1 1 1 1 KOW motif Actin PF00022.17 001168720.1_40421001_1 - 1e-31 109.8 0.0 1.1e-31 109.7 0.0 1.0 1 0 0 1 1 1 1 Actin TMEM187 PF15100.4 001168796.1_40422001_1 - 1.5e-115 384.8 12.2 1.8e-115 384.6 12.2 1.0 1 0 0 1 1 1 1 TMEM187 protein family 5TM-5TMR_LYT PF07694.10 001168981.1_40424001_1 - 1.9 7.8 24.9 0.61 9.4 8.9 3.6 2 1 1 3 3 3 0 5TMR of 5TMR-LYT 7tm_1 PF00001.19 001168739.1_40423001_1 - 5.5e-38 130.6 14.0 7.6e-38 130.1 14.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001168739.1_40423001_1 - 2.6e-06 26.8 1.1 2.6e-06 26.8 1.1 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw Cytochrom_B_N_2 PF13631.4 001168739.1_40423001_1 - 0.00051 19.9 1.2 0.0023 17.8 0.1 2.2 2 0 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB 7TM_GPCR_Srv PF10323.7 001168739.1_40423001_1 - 0.0011 18.3 12.7 0.0021 17.3 12.3 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001168739.1_40423001_1 - 0.022 14.4 8.4 0.18 11.4 8.4 2.0 1 1 0 1 1 1 0 Olfactory receptor DUF4190 PF13828.4 001168739.1_40423001_1 - 5 6.8 8.6 0.3 10.7 1.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4190) Cofilin_ADF PF00241.18 001168741.1_40422001_1 - 6e-30 103.9 1.2 7.5e-30 103.6 1.2 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Ribosomal_L23 PF00276.18 001168993.1_40421001_1 - 8.8e-11 41.9 1.1 1.1e-09 38.4 1.1 2.0 1 1 0 1 1 1 1 Ribosomal protein L23 7tm_4 PF13853.4 001168826.1_40422001_1 - 2.1e-68 230.9 14.1 2.4e-68 230.8 14.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168826.1_40422001_1 - 3.6e-06 26.3 11.7 7.4e-06 25.3 11.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4118 PF13493.4 001168826.1_40422001_1 - 0.91 9.2 5.6 0.15 11.8 0.9 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4118) TMEM251 PF15190.4 001168826.1_40422001_1 - 1.3 8.9 6.6 0.24 11.2 1.9 2.0 2 0 0 2 2 2 0 Transmembrane protein 251 7tm_4 PF13853.4 001168827.1_40422001_1 - 3.9e-108 361.3 24.7 4.5e-108 361.1 24.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168827.1_40422001_1 - 2.5e-17 62.9 24.8 4.1e-17 62.2 24.8 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168827.1_40422001_1 - 1.7e-05 24.2 16.1 3e-05 23.4 15.9 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001168828.1_40422001_1 - 7e-85 285.0 13.2 8.5e-85 284.7 13.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168828.1_40422001_1 - 5.9e-17 61.6 12.1 1.8e-16 60.0 12.1 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168828.1_40422001_1 - 2.3e-08 33.6 3.3 2.3e-08 33.6 3.3 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001168828.1_40422001_1 - 0.004 16.4 3.1 0.004 16.4 3.1 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.7 001168828.1_40422001_1 - 0.047 13.1 7.2 0.067 12.5 6.9 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc CytB6-F_Fe-S PF08802.8 001168828.1_40422001_1 - 0.13 12.2 1.4 7.7 6.5 0.8 3.0 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit 7tm_4 PF13853.4 001168829.1_40422001_1 - 9.7e-98 327.2 26.0 1.1e-97 327.0 26.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168829.1_40422001_1 - 3.5e-19 68.9 28.0 1e-18 67.4 28.0 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168829.1_40422001_1 - 4.7e-07 29.3 23.4 1e-06 28.2 23.4 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx RDM PF11002.6 001168719.1_40422001_1 - 8.6e-23 79.9 4.8 1.4e-22 79.2 4.8 1.4 1 0 0 1 1 1 1 RFPL defining motif (RDM) SPRY PF00622.26 001168719.1_40422001_1 - 1.9e-17 63.3 0.0 3.1e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 001168719.1_40422001_1 - 1.6e-16 60.0 19.2 3e-16 59.2 19.2 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING PRY PF13765.4 001168719.1_40422001_1 - 3e-15 55.4 0.0 5.2e-15 54.7 0.0 1.4 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_2 PF13923.4 001168719.1_40422001_1 - 6.5e-05 22.6 3.1 0.00017 21.2 3.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001168719.1_40422001_1 - 0.006 16.3 12.5 0.017 14.9 12.5 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001168719.1_40422001_1 - 0.0081 16.0 13.1 0.026 14.4 13.1 1.9 1 0 0 1 1 1 1 RING-type zinc-finger AKNA PF12443.6 001168719.1_40422001_1 - 0.086 13.3 0.1 0.15 12.6 0.1 1.3 1 0 0 1 1 1 0 AT-hook-containing transcription factor zf-RING_5 PF14634.4 001168719.1_40422001_1 - 2.6 8.0 16.4 2.5 8.0 14.8 1.8 2 0 0 2 2 2 0 zinc-RING finger domain DUF832 PF05734.9 001168719.1_40422001_1 - 3.7 6.8 6.9 8.8 5.6 6.9 1.7 1 1 0 1 1 1 0 Herpesvirus protein of unknown function (DUF832) zf-C3HC4_3 PF13920.4 001168719.1_40422001_1 - 3.8 7.3 19.1 0.5 10.1 15.0 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) 7tm_4 PF13853.4 001168830.1_40422001_1 - 1.9e-108 362.3 20.4 2.3e-108 362.1 20.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168830.1_40422001_1 - 3.3e-20 72.3 18.3 8.1e-20 71.0 18.3 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168830.1_40422001_1 - 4e-09 36.1 16.2 7.6e-09 35.2 16.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001168831.1_40422001_1 - 8.7e-99 330.6 27.6 9.7e-99 330.5 27.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168831.1_40422001_1 - 3.6e-17 62.3 22.6 7.5e-17 61.3 22.6 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168831.1_40422001_1 - 1.5e-08 34.2 23.4 2.9e-08 33.3 23.4 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001168832.1_40422001_1 - 2.8e-139 463.4 25.5 3.2e-139 463.2 25.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168832.1_40422001_1 - 3.2e-18 65.8 22.3 6e-18 64.9 22.3 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168832.1_40422001_1 - 2.3e-05 23.8 23.1 9.3e-05 21.8 23.1 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001168833.1_40422001_1 - 3.4e-83 279.5 17.6 3.9e-83 279.3 17.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168833.1_40422001_1 - 2.5e-19 69.4 12.4 3.4e-19 69.0 12.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168833.1_40422001_1 - 1.1e-07 31.4 9.0 1.6e-07 30.9 8.8 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001168835.1_40422001_1 - 4e-79 266.1 13.8 4.7e-79 265.9 13.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168835.1_40422001_1 - 1.1e-06 27.9 6.4 2.6e-06 26.8 6.4 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001168836.1_40422001_1 - 1e-115 386.2 23.7 1.2e-115 386.0 23.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168836.1_40422001_1 - 8.2e-16 57.9 21.9 1.6e-15 56.9 21.9 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168836.1_40422001_1 - 2e-08 33.8 18.4 2.6e-08 33.4 18.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001168840.1_40422001_1 - 5.9e-77 259.0 26.8 7.4e-77 258.7 26.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168840.1_40422001_1 - 5.4e-13 48.7 29.0 1.6e-12 47.1 29.0 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168840.1_40422001_1 - 0.0014 17.9 27.3 0.015 14.6 27.2 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001168841.1_40422001_1 - 3.5e-89 299.1 21.0 4.3e-89 298.8 21.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168841.1_40422001_1 - 9.2e-14 51.2 24.9 2.4e-13 49.8 24.9 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168841.1_40422001_1 - 1.1e-10 41.2 15.2 1.1e-10 41.2 15.2 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001168841.1_40422001_1 - 0.6 9.2 23.7 0.0056 15.9 16.1 1.5 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001168842.1_40422001_1 - 3.6e-119 397.5 19.6 4.1e-119 397.3 19.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168842.1_40422001_1 - 4.9e-13 48.8 18.3 1.4e-12 47.3 18.3 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1461 PF07314.9 001168842.1_40422001_1 - 0.17 11.6 3.9 0.42 10.4 2.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1461) 7tm_4 PF13853.4 001168843.1_40422001_1 - 6.1e-102 341.0 24.6 7.4e-102 340.7 24.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168843.1_40422001_1 - 4e-12 45.8 23.8 1.4e-11 44.0 23.8 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168843.1_40422001_1 - 2.3e-08 33.6 17.6 7e-08 32.0 17.6 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Ig_2 PF13895.4 001169057.1_40421001_1 - 1.3e-10 41.4 0.0 1.8e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001169057.1_40421001_1 - 0.0004 20.8 0.0 0.0006 20.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain 7tm_4 PF13853.4 001168845.1_40422001_1 - 1.8e-95 319.7 27.7 2.1e-95 319.5 27.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168845.1_40422001_1 - 2.3e-12 46.6 24.9 7.8e-12 44.8 24.9 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168845.1_40422001_1 - 5.8e-06 25.7 20.2 1e-05 24.9 19.2 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001168846.1_40422001_1 - 3.3e-103 345.1 23.8 3.7e-103 344.9 23.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168846.1_40422001_1 - 6e-10 38.7 18.7 1.2e-09 37.6 18.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168846.1_40422001_1 - 0.0044 16.3 1.5 0.0044 16.3 1.5 2.5 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1129 PF06570.9 001168846.1_40422001_1 - 0.28 10.6 2.4 0.52 9.7 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) GM_CSF PF01109.15 001168754.1_40421001_1 - 6.4e-67 223.2 0.1 7.3e-67 223.0 0.1 1.0 1 0 0 1 1 1 1 Granulocyte-macrophage colony-stimulating factor UDPGT PF00201.16 001168920.1_40423001_1 - 1.4e-88 297.7 0.2 1.7e-88 297.5 0.2 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_4 PF13439.4 001168920.1_40423001_1 - 0.0022 17.9 0.3 0.016 15.1 0.3 2.1 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Tubulin PF00091.23 001168974.1_40423001_1 - 2e-36 125.9 0.0 3.3e-36 125.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001168974.1_40423001_1 - 2.3e-33 115.0 1.4 3.6e-32 111.1 0.7 2.4 2 0 0 2 2 2 1 Tubulin C-terminal domain TrmK PF04816.10 001168974.1_40423001_1 - 0.034 13.6 0.0 0.051 13.0 0.0 1.2 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase HNH_2 PF13391.4 001168974.1_40423001_1 - 0.038 14.1 0.1 0.18 11.9 0.0 2.1 2 0 0 2 2 2 0 HNH endonuclease 7tm_1 PF00001.19 001168797.1_40423001_1 - 5.3e-39 133.9 13.6 7.3e-39 133.5 13.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001168797.1_40423001_1 - 4.9e-05 22.7 7.0 7.4e-05 22.1 6.9 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.7 001168797.1_40423001_1 - 7.2e-05 22.1 4.8 7.2e-05 22.1 4.8 1.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw Cytochrom_B_N_2 PF13631.4 001168797.1_40423001_1 - 0.0002 21.3 0.4 0.0011 18.9 0.0 2.1 2 0 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB 7TM_GPCR_Srt PF10321.7 001168797.1_40423001_1 - 0.0012 17.8 19.0 0.066 12.0 3.4 2.6 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srt 7TM_GPCR_Sru PF10322.7 001168797.1_40423001_1 - 0.58 9.3 11.5 0.025 13.7 4.7 2.1 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sru Tmemb_cc2 PF10267.7 001168798.1_40423001_1 - 1.2e-65 222.2 17.9 3.8e-40 138.1 8.5 2.0 1 1 1 2 2 2 2 Predicted transmembrane and coiled-coil 2 protein DUF2530 PF10745.7 001168798.1_40423001_1 - 0.086 12.9 0.3 0.16 12.1 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2530) VPEP PF07589.9 001168798.1_40423001_1 - 0.11 12.4 1.0 0.28 11.2 1.0 1.7 1 0 0 1 1 1 0 PEP-CTERM motif DUF1515 PF07439.9 001168798.1_40423001_1 - 0.12 12.3 1.0 16 5.4 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) DUF2207 PF09972.7 001168798.1_40423001_1 - 0.13 10.8 0.0 0.18 10.4 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Med9 PF07544.11 001168798.1_40423001_1 - 0.21 11.6 0.1 0.21 11.6 0.1 3.1 3 1 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Fib_alpha PF08702.8 001168798.1_40423001_1 - 3.9 7.5 12.1 0.81 9.7 0.3 3.1 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF2570 PF10828.6 001168798.1_40423001_1 - 4 7.2 13.2 2 8.2 3.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2570) TMPIT PF07851.11 001168798.1_40423001_1 - 5.3 6.0 8.6 8.1 5.4 4.2 2.2 2 0 0 2 2 2 0 TMPIT-like protein 7tm_4 PF13853.4 001168808.1_40422001_1 - 1.2e-44 153.0 23.6 1.4e-44 152.8 23.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168808.1_40422001_1 - 5.8e-19 68.2 18.6 7.7e-19 67.8 18.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Gaa1 PF04114.12 001168808.1_40422001_1 - 3.9 6.3 15.4 6.9 5.5 15.4 1.4 1 1 0 1 1 1 0 Gaa1-like, GPI transamidase component CC2-LZ PF16516.3 001169048.1_40423001_1 - 1.4e-30 105.5 16.9 1.4e-30 105.5 16.9 3.9 2 1 1 3 3 3 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator NEMO PF11577.6 001169048.1_40423001_1 - 7.1e-28 96.3 12.6 7.1e-28 96.3 12.6 4.5 4 2 2 6 6 6 1 NF-kappa-B essential modulator NEMO LLC1 PF14945.4 001169048.1_40423001_1 - 0.075 13.5 0.6 0.075 13.5 0.6 2.9 1 1 2 3 3 3 0 Normal lung function maintenance, Low in Lung Cancer 1 protein Bacillus_HBL PF05791.9 001169048.1_40423001_1 - 0.25 10.9 20.4 0.1 12.2 2.1 3.6 2 2 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) GAS PF13851.4 001169048.1_40423001_1 - 8.3 5.6 66.2 0.65 9.2 24.2 4.4 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding IGF2_C PF08365.9 001171406.1_37922001_1 - 2.8e-14 52.7 0.5 5e-14 51.9 0.5 1.4 1 0 0 1 1 1 1 Insulin-like growth factor II E-peptide Insulin PF00049.16 001171406.1_37922001_1 - 3.2e-14 53.6 5.6 7e-07 30.0 2.1 2.5 1 1 1 2 2 2 2 Insulin/IGF/Relaxin family V1R PF03402.12 001167473.1_22422001_1 - 6.6e-28 97.9 15.2 8e-28 97.7 15.2 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167473.1_22422001_1 - 1.1e-08 34.4 17.3 1.3e-08 34.2 17.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167473.1_22422001_1 - 5.7e-07 28.9 15.2 7.5e-07 28.5 15.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Pex24p PF06398.9 001167473.1_22422001_1 - 0.015 14.2 5.6 0.021 13.7 5.6 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF2391 PF09622.8 001167473.1_22422001_1 - 0.16 11.1 3.2 3.5 6.7 1.8 2.2 2 0 0 2 2 2 0 Putative integral membrane protein (DUF2391) DUF751 PF05421.9 001167473.1_22422001_1 - 0.33 11.5 0.2 0.33 11.5 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF751) BRI3BP PF14965.4 001167473.1_22422001_1 - 4.3 6.7 9.3 0.2 11.0 2.7 2.0 2 1 0 2 2 2 0 Negative regulator of p53/TP53 V1R PF03402.12 001167474.1_22422001_1 - 2.8e-40 138.5 12.3 3.6e-40 138.1 12.3 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167474.1_22422001_1 - 7.3e-09 35.0 15.1 9e-09 34.7 15.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167474.1_22422001_1 - 7.6 5.6 20.2 15 4.6 20.2 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167475.1_22422001_1 - 7.2e-49 166.7 27.3 8.6e-49 166.4 27.3 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R DUF4131 PF13567.4 001167475.1_22422001_1 - 0.38 10.2 5.5 3 7.3 0.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) NrfD_2 PF14589.4 001167475.1_22422001_1 - 1.1 9.0 9.8 1.1 9.1 1.1 2.5 1 1 0 2 2 2 0 Polysulfide reductase V1R PF03402.12 001167476.1_22422001_1 - 8.6e-35 120.5 12.7 1e-34 120.3 12.7 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167476.1_22422001_1 - 5.9e-05 22.2 13.8 0.00035 19.7 13.8 1.9 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) BRI3BP PF14965.4 001167476.1_22422001_1 - 0.071 12.5 1.2 0.16 11.3 1.2 1.6 1 0 0 1 1 1 0 Negative regulator of p53/TP53 7tm_1 PF00001.19 001167476.1_22422001_1 - 0.097 11.7 13.0 0.18 10.9 13.0 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167477.1_22422001_1 - 8.1e-20 71.4 10.8 1.2e-19 70.8 10.8 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167477.1_22422001_1 - 1.1e-07 31.1 12.6 1.5e-07 30.7 12.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167477.1_22422001_1 - 0.00021 20.5 15.4 0.00037 19.7 15.4 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167478.1_22422001_1 - 1.3e-29 103.5 10.7 1.7e-29 103.1 10.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167478.1_22422001_1 - 4.7e-08 32.4 14.8 5.4e-08 32.2 14.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167479.1_22422001_1 - 4.6e-29 101.7 18.0 6.9e-29 101.1 18.0 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167479.1_22422001_1 - 2.6e-07 29.9 21.8 3.1e-07 29.7 21.8 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167479.1_22422001_1 - 0.0012 18.0 20.0 0.0018 17.4 19.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167480.1_22422001_1 - 4.4e-35 121.5 12.5 5.8e-35 121.1 12.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167480.1_22422001_1 - 1.4e-05 24.2 15.3 1.7e-05 24.0 15.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167481.1_22422001_1 - 1.8e-25 90.0 16.9 2.4e-25 89.5 16.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167481.1_22422001_1 - 0.0014 17.7 24.4 0.0019 17.3 24.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) BRI3BP PF14965.4 001167481.1_22422001_1 - 0.0061 16.0 2.3 0.014 14.8 2.3 1.5 1 0 0 1 1 1 1 Negative regulator of p53/TP53 V1R PF03402.12 001167482.1_22422001_1 - 1.8e-22 80.1 13.0 2.6e-22 79.6 13.0 1.3 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167482.1_22422001_1 - 2.9e-10 39.6 18.5 3.7e-10 39.3 18.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167482.1_22422001_1 - 7.5e-05 22.0 14.3 0.00012 21.3 14.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Oxidored_q2 PF00420.22 001167482.1_22422001_1 - 0.052 13.1 5.6 0.079 12.5 1.2 2.7 2 1 1 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L V1R PF03402.12 001167483.1_22422001_1 - 3.1e-25 89.2 15.8 3.6e-25 88.9 15.8 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167483.1_22422001_1 - 7e-08 31.8 18.1 8.2e-08 31.6 18.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167485.1_22422001_1 - 1.2e-27 97.1 13.8 1.6e-27 96.7 13.8 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167485.1_22422001_1 - 1.3e-07 30.9 18.4 1.4e-07 30.8 18.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Caudo_bapla16 PF16792.3 001167485.1_22422001_1 - 0.0015 17.4 0.0 0.0023 16.9 0.0 1.2 1 0 0 1 1 1 1 Phage tail base-plate attachment protein of Caudovirales ORF16 V1R PF03402.12 001167486.1_22422001_1 - 7.4e-43 146.9 13.5 9.7e-43 146.6 13.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167486.1_22422001_1 - 2.8e-08 33.1 9.6 4.4e-08 32.4 9.6 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167486.1_22422001_1 - 0.00022 20.4 10.6 0.0029 16.8 10.6 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167487.1_22422001_1 - 2.2e-34 119.2 10.8 2.9e-34 118.8 10.8 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167487.1_22422001_1 - 0.069 12.2 8.5 0.098 11.7 8.5 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) CAP_N PF01213.17 001167487.1_22422001_3 - 9.8 5.4 7.1 13 5.0 7.1 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal V1R PF03402.12 001167488.1_22422001_1 - 1e-41 143.2 14.3 1.3e-41 142.8 14.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167488.1_22422001_1 - 4.4e-08 32.5 12.4 6.1e-08 32.0 12.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167488.1_22422001_1 - 0.0039 16.3 9.9 0.0081 15.3 9.9 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Nop10p PF04135.10 001167488.1_22422001_3 - 0.99 9.4 4.0 0.81 9.6 0.3 2.5 3 0 0 3 3 3 0 Nucleolar RNA-binding protein, Nop10p family V1R PF03402.12 001167489.1_22422001_1 - 4.9e-30 104.9 17.8 6.8e-30 104.4 17.8 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167489.1_22422001_1 - 2e-06 27.0 24.3 2.4e-06 26.8 24.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Prog_receptor PF02161.13 001205356.1_06526001_1 - 1e-250 833.2 61.7 1.2e-250 833.0 61.7 1.1 1 0 0 1 1 1 1 Progesterone receptor Hormone_recep PF00104.28 001205356.1_06526001_1 - 1.2e-29 103.2 4.9 1.9e-29 102.6 4.9 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001205356.1_06526001_1 - 2.3e-26 91.9 15.7 3.5e-26 91.3 15.7 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Interferon PF00143.17 001031831.1_22422001_1 - 2.7e-57 193.3 0.2 3e-57 193.1 0.2 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Interferon PF00143.17 001031828.1_22422001_1 - 3.3e-57 193.0 0.3 3.7e-57 192.9 0.3 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Asp PF00026.21 001082597.1_39523001_1 - 2.9e-103 345.5 0.0 3.5e-103 345.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001082597.1_39523001_1 - 2.2e-14 54.0 0.3 3.6e-11 43.5 0.3 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001082597.1_39523001_1 - 6.1e-13 48.2 2.4 1.4e-12 47.1 2.4 1.6 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.4 001082597.1_39523001_1 - 0.00041 20.8 0.0 0.046 14.3 0.0 3.1 2 1 0 2 2 2 1 Aspartyl protease Peptidase_C1_2 PF03051.13 001082597.1_39523001_1 - 0.23 10.1 0.0 0.31 9.6 0.0 1.2 1 0 0 1 1 1 0 Peptidase C1-like family PAX PF00292.16 001178052.1_39523001_3 - 7.4e-75 248.7 0.6 1.1e-74 248.1 0.6 1.3 1 0 0 1 1 1 1 'Paired box' domain Pax2_C PF12403.6 001178052.1_39523001_3 - 1.9e-55 185.7 15.1 3.6e-55 184.8 15.1 1.5 1 0 0 1 1 1 1 Paired-box protein 2 C terminal HTH_32 PF13565.4 001178052.1_39523001_3 - 9.8e-06 26.0 0.2 0.016 15.7 0.0 2.9 2 1 1 3 3 3 2 Homeodomain-like domain HTH_23 PF13384.4 001178052.1_39523001_3 - 0.00011 21.7 0.0 0.00024 20.6 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain Homeobox PF00046.27 001178052.1_39523001_3 - 0.008 15.8 0.1 0.019 14.6 0.1 1.6 1 0 0 1 1 1 1 Homeobox domain HTH_28 PF13518.4 001178052.1_39523001_3 - 0.016 15.2 0.0 0.035 14.1 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_IS1 PF12759.5 001178052.1_39523001_3 - 0.062 12.8 0.2 0.2 11.1 0.0 1.9 2 0 0 2 2 2 0 InsA C-terminal domain Ribosomal_S13_N PF08069.10 001178052.1_39523001_3 - 0.065 13.1 0.0 0.18 11.7 0.0 1.8 2 0 0 2 2 2 0 Ribosomal S13/S15 N-terminal domain Amidase_2 PF01510.23 001244284.1_49824001_2 - 1.1e-26 93.5 0.0 7.4e-14 52.1 0.0 2.2 2 0 0 2 2 2 2 N-acetylmuramoyl-L-alanine amidase APOBEC_N PF08210.9 001161380.1_39523001_3 - 1.4e-48 165.0 6.1 1.7e-48 164.8 6.1 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001161380.1_39523001_3 - 1.5e-32 111.3 0.4 2.2e-32 110.7 0.4 1.3 1 0 0 1 1 1 1 APOBEC-like C-terminal domain Biopterin_H PF00351.19 001099955.1_37923001_1 - 9.1e-173 573.7 0.1 1.2e-172 573.4 0.1 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.23 001099955.1_37923001_1 - 4.5e-06 26.2 0.0 1.2e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.4 001099955.1_37923001_1 - 0.022 15.2 1.2 0.035 14.5 0.1 1.9 2 0 0 2 2 2 0 ACT domain Med9 PF07544.11 001099955.1_37923001_1 - 0.069 13.1 0.1 6 6.9 0.0 2.8 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Ferric_reduct PF01794.17 001135418.1_43525001_2 - 3e-24 85.4 3.6 3e-24 85.4 3.6 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.10 001135418.1_43525001_2 - 1.2e-23 83.8 0.0 4.9e-22 78.6 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.10 001135418.1_43525001_2 - 3.5e-14 52.7 0.0 8e-14 51.5 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.19 001135418.1_43525001_2 - 0.042 14.4 0.0 0.11 13.0 0.0 1.7 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Autoind_bind PF03472.13 001135418.1_43525001_2 - 0.13 11.6 0.0 0.41 10.0 0.0 1.9 2 0 0 2 2 2 0 Autoinducer binding domain Trypsin PF00089.24 001099971.1_37922001_1 - 1.5e-70 237.3 0.1 1.8e-70 237.1 0.1 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001099971.1_37922001_1 - 1.5e-07 32.2 0.0 2.4e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001099971.1_37922001_1 - 1.1e-05 25.7 0.1 0.0011 19.2 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1986) DUF316 PF03761.13 001099971.1_37922001_1 - 0.081 12.3 0.0 1.8 7.9 0.0 2.1 2 0 0 2 2 2 0 Chymotrypsin family Peptidase-S1 Interferon PF00143.17 001089304.1_22422001_1 - 9.2e-55 185.1 0.0 1e-54 184.9 0.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain 7tm_1 PF00001.19 001109062.1_45724001_2 - 1.9e-11 43.6 7.4 3.7e-11 42.6 7.4 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Interferon PF00143.17 001102442.1_22422001_1 - 5.7e-55 185.7 0.0 6.5e-55 185.6 0.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Interferon PF00143.17 001089306.1_22422001_1 - 1.6e-54 184.3 0.0 1.8e-54 184.1 0.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Interferon PF00143.17 001089307.1_22422001_1 - 2.8e-54 183.5 0.0 3.2e-54 183.3 0.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Asp PF00026.21 001009793.1_39523001_3 - 8.1e-94 314.4 0.0 9.8e-94 314.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001009793.1_39523001_3 - 4.9e-13 49.6 0.5 1.7e-07 31.5 0.3 2.2 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001009793.1_39523001_3 - 2.4e-09 36.7 0.2 5.6e-09 35.5 0.2 1.6 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.4 001009793.1_39523001_3 - 0.0019 18.7 0.0 0.048 14.2 0.0 3.0 3 1 0 3 3 3 1 Aspartyl protease Interferon PF00143.17 001089308.1_22422001_1 - 3.5e-55 186.4 0.0 4e-55 186.2 0.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Asp PF00026.21 001009794.1_39523001_3 - 6.4e-94 314.8 0.0 8.2e-94 314.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001009794.1_39523001_3 - 9.4e-11 42.2 0.2 1.2e-08 35.3 0.2 2.2 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001009794.1_39523001_3 - 1e-10 41.1 0.7 2.3e-10 40.0 0.7 1.6 1 0 0 1 1 1 1 A1 Propeptide MHC_II_beta PF00969.17 001128072.1_22423001_1 - 7.6e-35 118.8 0.3 1.1e-34 118.2 0.3 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001128072.1_22423001_1 - 3.9e-26 91.2 0.7 9.8e-26 89.9 0.2 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001128072.1_22423001_1 - 2.3e-05 24.8 0.2 6.6e-05 23.3 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001128072.1_22423001_1 - 0.00079 19.4 0.2 0.0016 18.5 0.2 1.5 1 0 0 1 1 1 1 Immunoglobulin domain MHC_I PF00129.16 001128072.1_22423001_1 - 0.022 14.2 0.0 0.035 13.5 0.0 1.3 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 DUF202 PF02656.13 001128072.1_22423001_1 - 0.022 15.1 0.0 0.043 14.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Glyco_hydro_39 PF01229.15 001128072.1_22423001_1 - 0.17 10.3 0.0 0.24 9.8 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 39 PLU-1 PF08429.9 001131536.1_43526001_1 - 1.9e-59 201.4 6.7 3.8e-43 147.8 0.1 2.8 2 1 1 3 3 3 2 PLU-1-like protein zf-C5HC2 PF02928.14 001131536.1_43526001_1 - 8.7e-16 57.9 11.5 8.7e-16 57.9 11.5 3.3 3 0 0 3 3 3 1 C5HC2 zinc finger DUF1509 PF07420.9 001131536.1_43526001_1 - 1.2 7.9 4.2 1.8 7.3 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) T5orf172 PF10544.7 001131536.1_43526001_1 - 3.1 8.3 4.9 1 9.8 0.9 2.2 2 0 0 2 2 2 0 T5orf172 domain ECH_1 PF00378.18 001145039.1_29624001_2 - 2.5e-34 118.6 0.2 3.5e-34 118.1 0.2 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 001145039.1_29624001_2 - 2.7e-19 69.7 1.9 2.9e-18 66.3 0.0 2.2 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Chromo PF00385.22 001145039.1_29624001_2 - 4.6e-16 58.3 0.6 8.6e-16 57.4 0.6 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.6 001145039.1_29624001_2 - 0.022 14.5 3.8 0.023 14.4 0.1 2.6 3 0 0 3 3 3 0 RNA binding activity-knot of a chromodomain Chromo_shadow PF01393.17 001145039.1_29624001_2 - 0.072 13.0 0.2 0.32 10.9 0.1 2.1 2 0 0 2 2 2 0 Chromo shadow domain Mtf2_C PF14061.4 001145039.1_29624001_2 - 0.17 11.9 0.1 0.37 10.9 0.1 1.6 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Interferon PF00143.17 001009963.1_22422001_1 - 3.9e-57 192.8 0.2 4.4e-57 192.6 0.2 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain p450 PF00067.20 001171071.1_37925001_1 - 1.4e-128 429.4 0.0 1.8e-128 429.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.20 001245974.1_39524001_2 - 1.8e-135 452.2 0.0 2e-135 452.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 UDPGT PF00201.16 001172140.1_40424001_2 - 2.2e-256 851.3 0.3 2.6e-256 851.0 0.3 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001172140.1_40424001_2 - 1.2e-06 28.5 0.0 2e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 001172140.1_40424001_2 - 0.01 15.7 0.0 0.046 13.6 0.0 2.0 1 1 0 1 1 1 0 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.4 001172140.1_40424001_2 - 0.054 13.8 0.0 0.15 12.4 0.0 1.7 1 1 0 1 1 1 0 Glycosyl transferase 4-like domain Pro_3_hydrox_C PF05373.9 001172140.1_40424001_2 - 0.16 11.9 0.0 0.43 10.5 0.0 1.7 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal UDPGT PF00201.16 001172145.1_40424001_2 - 5e-258 856.7 0.6 5.9e-258 856.5 0.6 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001172145.1_40424001_2 - 2.1e-07 30.9 0.0 3.8e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 001172145.1_40424001_2 - 0.00042 20.2 0.0 0.0041 17.0 0.0 2.2 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.4 001172145.1_40424001_2 - 0.035 14.4 0.0 0.12 12.7 0.0 1.8 1 1 0 1 1 1 0 Glycosyl transferase 4-like domain DUF643 PF04867.10 001172145.1_40424001_2 - 0.056 13.9 0.2 0.16 12.5 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF643) Ras PF00071.20 001126359.1_39522001_1 - 1.4e-39 135.2 0.1 1.8e-39 134.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001126359.1_39522001_1 - 2.3e-34 118.1 0.0 3.7e-34 117.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001126359.1_39522001_1 - 3.4e-12 46.0 0.0 5.9e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001126359.1_39522001_1 - 2.2e-07 30.3 0.0 3.9e-07 29.5 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001126359.1_39522001_1 - 8.6e-07 28.5 0.3 2.2e-05 23.9 0.1 2.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001126359.1_39522001_1 - 1e-05 25.5 0.0 2.3e-05 24.3 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.8 001126359.1_39522001_1 - 0.0012 18.2 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF258 PF03193.14 001126359.1_39522001_1 - 0.0095 15.7 0.0 4.8 6.9 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function, DUF258 G-alpha PF00503.18 001126359.1_39522001_1 - 0.013 14.6 0.2 0.031 13.3 0.2 1.8 1 1 0 1 1 1 0 G-protein alpha subunit ATP_bind_1 PF03029.15 001126359.1_39522001_1 - 0.03 13.9 0.1 0.064 12.9 0.1 1.5 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein MMR_HSR1_Xtn PF16897.3 001126359.1_39522001_1 - 0.053 13.4 0.0 0.094 12.6 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AAA_22 PF13401.4 001126359.1_39522001_1 - 0.06 13.5 0.1 1.3 9.1 0.1 2.6 1 1 0 1 1 1 0 AAA domain Interferon PF00143.17 001245022.1_22422001_1 - 2.7e-57 193.3 0.2 3e-57 193.1 0.2 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain COesterase PF00135.26 001135266.1_43528001_1 - 5e-155 517.2 0.0 5.9e-155 516.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001135266.1_43528001_1 - 2.6e-09 37.1 0.4 4.9e-09 36.2 0.4 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 001135266.1_43528001_1 - 0.038 13.3 0.1 0.064 12.6 0.1 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family KN_motif PF12075.6 001135457.1_43528001_1 - 3.2e-20 71.5 0.3 7.1e-20 70.4 0.3 1.6 1 0 0 1 1 1 1 KN motif DegQ PF08181.9 001135457.1_43528001_1 - 0.15 12.0 1.0 0.46 10.5 1.0 1.8 1 0 0 1 1 1 0 DegQ (SacQ) family IMUP PF15761.3 001135457.1_43528001_1 - 6.3 7.4 8.5 3.9 8.1 3.1 2.8 2 0 0 2 2 2 0 Immortalisation up-regulated protein Pkinase_Tyr PF07714.15 001135461.1_43529001_2 - 3.1e-91 305.1 0.0 4.6e-91 304.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001135461.1_43529001_2 - 2.5e-43 148.2 0.0 4.5e-43 147.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ig_Tie2_1 PF10430.7 001135461.1_43529001_2 - 1.4e-39 134.2 1.2 2.5e-39 133.4 0.0 2.0 2 0 0 2 2 2 1 Tie-2 Ig-like domain 1 fn3 PF00041.19 001135461.1_43529001_2 - 4.1e-36 123.1 5.8 3.1e-12 46.5 0.1 3.3 3 0 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 001135461.1_43529001_2 - 1.3e-06 28.8 0.8 0.19 12.2 0.1 3.4 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain EGF_2 PF07974.11 001135461.1_43529001_2 - 0.0015 18.8 10.8 0.0015 18.8 10.8 5.0 4 1 0 4 4 4 2 EGF-like domain APH PF01636.21 001135461.1_43529001_2 - 0.0033 17.2 0.0 0.2 11.4 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family hEGF PF12661.5 001135461.1_43529001_2 - 0.0036 17.8 6.5 0.0036 17.8 6.5 4.6 4 0 0 4 4 3 1 Human growth factor-like EGF fn3_2 PF16893.3 001135461.1_43529001_2 - 0.008 16.2 0.1 0.085 12.9 0.0 2.5 2 0 0 2 2 2 1 Fibronectin type III domain Laminin_EGF PF00053.22 001135461.1_43529001_2 - 0.023 14.7 46.0 1.7 8.7 16.7 3.9 1 1 2 3 3 3 0 Laminin EGF domain Ig_3 PF13927.4 001135461.1_43529001_2 - 0.047 14.2 0.0 9.1 6.8 0.0 3.5 3 0 0 3 3 3 0 Immunoglobulin domain DUF2369 PF10179.7 001135461.1_43529001_2 - 0.067 13.5 0.0 0.64 10.4 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) DSL PF01414.17 001135461.1_43529001_2 - 8.1 6.6 50.3 0.36 10.9 7.7 3.6 3 0 0 3 3 3 0 Delta serrate ligand RINGv PF12906.5 001135269.1_43527001_3 - 1.4e-10 41.0 6.1 1.4e-10 41.0 6.1 1.9 2 0 0 2 2 2 1 RING-variant domain Calc_CGRP_IAPP PF00214.17 001104955.1_49822001_2 - 1.9e-30 105.6 0.0 2.6e-30 105.2 0.0 1.2 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family PaREP1 PF05942.9 001104955.1_49822001_2 - 0.15 11.9 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Archaeal PaREP1/PaREP8 family MHC_I PF00129.16 001048161.1_22423001_3 - 1.7e-91 304.5 0.6 2.4e-91 304.0 0.6 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001048161.1_22423001_3 - 3.7e-17 62.4 0.0 7e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001048161.1_22423001_3 - 1.7e-11 43.7 1.6 3.1e-11 42.9 1.6 1.5 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001048161.1_22423001_3 - 5.4e-05 23.6 0.3 0.0032 17.9 0.2 2.5 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001048161.1_22423001_3 - 0.00017 21.4 0.1 0.0003 20.7 0.1 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001048161.1_22423001_3 - 0.0029 17.6 0.0 0.0065 16.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain MHC_I_3 PF16497.3 001048161.1_22423001_3 - 0.057 12.8 0.0 0.081 12.3 0.0 1.2 1 0 0 1 1 1 0 MHC-I family domain EphA2_TM PF14575.4 001048161.1_22423001_3 - 0.16 12.7 0.0 0.38 11.5 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain MacB_PCD PF12704.5 001048161.1_22423001_3 - 1.9 8.7 5.5 4 7.6 5.5 1.4 1 0 0 1 1 1 0 MacB-like periplasmic core domain Voltage_CLC PF00654.18 001082211.1_37927001_3 - 3.2e-94 316.0 30.8 3.4e-94 315.8 26.8 2.0 1 1 1 2 2 2 2 Voltage gated chloride channel CBS PF00571.26 001082211.1_37927001_3 - 2.3e-17 63.1 0.1 9.4e-10 38.7 0.0 2.5 2 0 0 2 2 2 2 CBS domain RasGEF PF00617.17 001133543.1_43529001_3 - 9.4e-52 175.5 1.4 1.6e-51 174.8 1.4 1.4 1 0 0 1 1 1 1 RasGEF domain cNMP_binding PF00027.27 001133543.1_43529001_3 - 5.1e-31 106.4 0.0 5.9e-15 54.9 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain DEP PF00610.19 001133543.1_43529001_3 - 2.7e-21 75.3 3.0 4.1e-21 74.7 1.3 2.1 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RasGEF_N PF00618.18 001133543.1_43529001_3 - 1.3e-13 51.0 0.0 3.1e-13 49.8 0.0 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif F_actin_cap_B PF01115.15 001097453.1_49822001_1 - 3.1e-111 370.6 0.0 3.7e-111 370.4 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit F-actin_cap_A PF01267.15 001097453.1_49822001_1 - 0.041 13.2 0.1 0.43 9.8 0.0 2.6 1 1 0 1 1 1 0 F-actin capping protein alpha subunit OppC_N PF12911.5 001097453.1_49822001_2 - 0.059 13.2 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C ig PF00047.23 001195409.1_32323001_3 - 2e-09 37.4 0.0 3.3e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001195409.1_32323001_3 - 2.3e-07 31.2 0.0 4.5e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001195409.1_32323001_3 - 5e-06 26.4 0.0 8.6e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.15 001195409.1_32323001_3 - 1.2e-05 25.3 0.0 0.0038 17.2 0.0 2.3 1 1 0 1 1 1 1 Immunoglobulin V-set domain ITAM PF02189.13 001195409.1_32323001_3 - 1.8e-05 24.8 0.1 4.4e-05 23.5 0.1 1.7 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif Ig_2 PF13895.4 001195409.1_32323001_3 - 0.0013 19.0 0.0 0.0035 17.5 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain IHABP4_N PF16174.3 001128200.1_22425001_2 - 1.4e-37 129.7 8.5 1.4e-37 129.7 8.5 2.2 2 0 0 2 2 2 1 Intracellular hyaluronan-binding protein 4 N-terminal HABP4_PAI-RBP1 PF04774.13 001128200.1_22425001_2 - 5.2e-21 75.5 7.4 5.2e-21 75.5 7.4 2.4 2 0 0 2 2 2 1 Hyaluronan / mRNA binding family EF-hand_1 PF00036.30 001135323.1_43524001_3 - 7.8e-11 40.6 0.0 0.004 16.5 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 001135323.1_43524001_3 - 4.8e-09 35.7 0.1 3.1e-06 26.7 0.0 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.4 001135323.1_43524001_3 - 1.2e-07 31.0 0.0 0.014 15.2 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 001135323.1_43524001_3 - 6.6e-06 26.4 0.0 0.058 13.8 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 001135323.1_43524001_3 - 0.00011 21.4 0.1 0.43 10.1 0.0 2.9 3 0 0 3 3 3 2 EF hand Asp PF00026.21 001009463.1_39523001_3 - 2.9e-73 246.9 0.0 1.8e-44 152.3 0.0 2.0 1 1 1 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.4 001009463.1_39523001_3 - 4.9e-11 43.1 0.1 1.1e-06 28.9 0.0 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001009463.1_39523001_3 - 2e-08 33.8 0.3 3.6e-08 33.0 0.3 1.5 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.4 001009463.1_39523001_3 - 0.0031 18.0 0.1 5.5 7.6 0.0 3.3 3 1 0 3 3 3 2 Aspartyl protease IncA PF04156.12 001135298.1_43526001_1 - 0.00082 19.1 0.0 0.0012 18.5 0.0 1.2 1 0 0 1 1 1 1 IncA protein EphA2_TM PF14575.4 001135298.1_43526001_1 - 0.0041 17.8 0.0 0.0076 16.9 0.0 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Peptidase_S9 PF00326.19 001135332.1_43529001_2 - 1.1e-31 109.8 0.0 1.7e-31 109.2 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.13 001135332.1_43529001_2 - 5.1e-26 91.3 0.1 8e-26 90.6 0.1 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain RnaseA PF00074.18 001163409.1_49821001_1 - 8.7e-35 119.7 0.1 1e-34 119.5 0.1 1.0 1 0 0 1 1 1 1 Pancreatic ribonuclease CCDC71L PF15374.4 001114880.1_22422001_1 - 0.00058 19.1 0.1 0.00073 18.8 0.1 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 71L Caskin-Pro-rich PF16907.3 001114880.1_22422001_1 - 0.37 11.2 16.5 5.3 7.5 9.3 2.6 2 0 0 2 2 2 0 Proline rich region of Caskin proteins C2 PF00168.28 001135339.1_43529001_1 - 1.1e-95 314.7 0.0 3.8e-24 84.8 0.0 5.3 5 0 0 5 5 5 5 C2 domain SMP_LBD PF17047.3 001135339.1_43529001_1 - 1.4e-76 255.9 0.1 2.1e-76 255.2 0.1 1.3 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain DUF647 PF04884.12 001135306.1_43526001_1 - 5.4e-91 304.4 0.6 7.4e-91 303.9 0.6 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis Glyco_hydro_30 PF02055.14 001135312.1_43525001_2 - 2.6e-195 648.1 0.1 3.2e-195 647.8 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.2 001135312.1_43525001_2 - 1.1e-14 54.3 0.0 1.8e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Ras PF00071.20 001161878.1_39523001_2 - 4.5e-56 188.8 0.0 5.6e-56 188.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001161878.1_39523001_2 - 2.3e-19 69.6 0.0 3.2e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001161878.1_39523001_2 - 1.2e-09 37.7 0.0 1.5e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 001161878.1_39523001_2 - 1e-06 28.6 0.1 0.0016 18.2 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001161878.1_39523001_2 - 0.00016 21.2 0.0 0.00049 19.6 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001161878.1_39523001_2 - 0.00082 19.3 0.0 0.0012 18.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase TPP_enzyme_M PF00205.20 001161878.1_39523001_2 - 0.013 15.1 0.0 0.026 14.1 0.0 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain FeoB_N PF02421.16 001161878.1_39523001_2 - 0.016 14.7 0.1 0.04 13.3 0.1 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.3 001161878.1_39523001_2 - 0.021 14.7 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain APOC4 PF15119.4 001195137.1_29622001_1 - 1.1e-47 160.1 0.6 2.2e-47 159.1 0.6 1.5 1 0 0 1 1 1 1 Apolipoprotein C4 Dynactin PF12455.6 001131096.1_43529001_1 - 5e-102 340.9 4.8 5e-102 340.9 4.8 4.6 4 1 0 4 4 4 2 Dynein associated protein CAP_GLY PF01302.23 001131096.1_43529001_1 - 1.2e-22 79.6 2.1 2.2e-22 78.7 2.1 1.5 1 0 0 1 1 1 1 CAP-Gly domain DUF4172 PF13776.4 001131096.1_43529001_1 - 5.3 7.3 11.1 1.1 9.5 0.1 4.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4172) EOS1 PF12326.6 001131096.1_43529001_3 - 0.37 10.6 0.7 0.51 10.1 0.7 1.2 1 0 0 1 1 1 0 N-glycosylation protein RNA_pol_Rpc4 PF05132.12 001131096.1_43529001_3 - 2.7 8.3 13.8 0.049 13.9 6.0 1.9 2 0 0 2 2 2 0 RNA polymerase III RPC4 MHC_I PF00129.16 001130934.1_39523001_1 - 3e-92 307.0 0.4 4.3e-92 306.5 0.4 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001130934.1_39523001_1 - 1.9e-17 63.4 0.0 4.1e-17 62.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001130934.1_39523001_1 - 4.7e-17 61.5 1.8 8.5e-17 60.7 1.8 1.4 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001130934.1_39523001_1 - 6.9e-06 26.4 0.3 0.00029 21.3 0.0 2.9 1 1 1 2 2 2 1 Immunoglobulin domain ig PF00047.23 001130934.1_39523001_1 - 0.00014 21.8 0.1 0.0014 18.6 0.0 2.5 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.4 001130934.1_39523001_1 - 0.0012 19.0 0.0 0.0075 16.5 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 001130934.1_39523001_1 - 0.0027 17.6 0.6 0.0064 16.4 0.1 1.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain EphA2_TM PF14575.4 001130934.1_39523001_1 - 0.041 14.5 0.1 0.12 13.1 0.1 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain P12 PF12669.5 001130934.1_39523001_1 - 0.74 10.1 2.3 1.4 9.3 2.3 1.4 1 0 0 1 1 1 0 Virus attachment protein p12 family UDPGT PF00201.16 001112657.1_40424001_3 - 9.6e-249 826.1 0.3 1.1e-248 825.9 0.3 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001112657.1_40424001_3 - 1.5e-08 34.6 0.0 2.8e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 001112657.1_40424001_3 - 0.007 16.2 0.3 0.051 13.4 0.4 2.1 1 1 0 1 1 1 1 Glycosyltransferase Family 4 ACOX PF01756.17 001135371.1_43525001_3 - 1.4e-62 210.4 1.7 2.7e-62 209.4 1.7 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.4 001135371.1_43525001_3 - 2.9e-33 115.0 0.4 6.1e-33 113.9 0.1 1.7 2 0 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.17 001135371.1_43525001_3 - 3.5e-12 46.2 0.0 7e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.22 001135371.1_43525001_3 - 0.0064 16.6 0.0 0.024 14.7 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HSF_DNA-bind PF00447.15 001040123.1_22423001_1 - 2.3e-22 79.3 1.0 4.2e-22 78.4 1.0 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding UDPGT PF00201.16 001112618.1_40424001_3 - 2.8e-241 801.5 0.3 3.3e-241 801.2 0.3 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001112618.1_40424001_3 - 1.5e-08 34.7 0.0 2.9e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Cullin PF00888.20 001040124.1_22426001_2 - 8.5e-190 632.2 20.8 1.1e-189 631.9 20.8 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.7 001040124.1_22426001_2 - 2.5e-22 78.5 1.1 2.5e-22 78.5 1.1 2.9 3 0 0 3 3 3 1 Cullin protein neddylation domain SecA_SW PF07516.11 001040124.1_22426001_2 - 0.0017 18.3 0.3 0.0017 18.3 0.3 2.5 3 0 0 3 3 3 1 SecA Wing and Scaffold domain DUF2018 PF09442.8 001040124.1_22426001_2 - 0.016 16.0 0.2 0.12 13.2 0.2 2.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2018) STAR_dimer PF16544.3 001040124.1_22426001_2 - 0.041 13.3 0.1 0.39 10.2 0.0 2.6 2 0 0 2 2 2 0 Homodimerisation region of STAR domain protein ThiF PF00899.19 001040127.1_22427001_3 - 1.6e-120 400.9 0.0 2.1e-73 246.6 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.7 001040127.1_22427001_3 - 6.6e-93 311.1 0.0 9.7e-93 310.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.8 001040127.1_22427001_3 - 2.9e-36 123.9 0.1 6.1e-36 122.9 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.3 001040127.1_22427001_3 - 1e-31 108.8 0.1 1.9e-31 107.9 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.3 001040127.1_22427001_3 - 1.5e-26 92.2 0.1 4.1e-26 90.8 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle PAZ PF02170.20 001040127.1_22427001_3 - 0.077 12.7 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 PAZ domain Takusan PF04822.11 001009971.1_45722001_1 - 2.5e-24 84.8 5.3 2.5e-24 84.8 5.3 2.2 3 0 0 3 3 2 1 Takusan DUF3584 PF12128.6 001009971.1_45722001_1 - 0.011 13.2 6.5 0.014 12.9 6.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TPR_MLP1_2 PF07926.10 001009971.1_45722001_1 - 0.034 14.1 4.4 4.3 7.3 0.0 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF223 PF02721.12 001009971.1_45722001_1 - 0.042 14.0 0.7 0.21 11.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF223 Seryl_tRNA_N PF02403.20 001009971.1_45722001_1 - 0.051 13.7 9.2 1 9.5 1.1 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ArAE_2_N PF10337.7 001009971.1_45722001_1 - 0.13 11.1 1.2 0.15 10.9 1.2 1.2 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal PRKG1_interact PF15898.3 001009971.1_45722001_1 - 0.21 12.4 11.4 0.27 12.1 1.1 2.2 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain KASH_CCD PF14662.4 001009971.1_45722001_1 - 0.33 10.6 12.2 0.69 9.6 12.1 1.5 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Phage_HK97_TLTM PF06120.9 001009971.1_45722001_1 - 0.41 9.7 5.1 0.12 11.3 1.7 1.7 1 1 1 2 2 2 0 Tail length tape measure protein DUF972 PF06156.11 001009971.1_45722001_1 - 0.45 11.0 14.1 0.23 11.9 1.9 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF972) Cnn_1N PF07989.9 001009971.1_45722001_1 - 0.57 10.2 11.9 2.3 8.3 4.8 2.9 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 DUF4200 PF13863.4 001009971.1_45722001_1 - 0.68 10.2 13.8 3.6 7.9 1.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) TLE_N PF03920.13 001009971.1_45722001_1 - 1.3 9.0 7.1 8.4 6.4 0.8 2.4 1 1 1 2 2 2 0 Groucho/TLE N-terminal Q-rich domain Cep57_CLD_2 PF14197.4 001009971.1_45722001_1 - 1.7 8.7 8.4 0.28 11.2 1.2 2.4 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 FtsL PF04999.11 001009971.1_45722001_1 - 2.5 8.0 7.1 0.32 10.9 1.0 2.4 2 1 1 3 3 3 0 Cell division protein FtsL NRBF2 PF08961.8 001009971.1_45722001_1 - 6 6.3 9.9 2.8 7.4 1.7 2.4 1 1 2 3 3 3 0 Nuclear receptor-binding factor 2, autophagy regulator Hormone_recep PF00104.28 001185036.1_37923001_1 - 7.4e-28 97.4 0.2 1.2e-27 96.7 0.2 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001185036.1_37923001_1 - 3.6e-25 88.1 14.4 6.2e-25 87.3 14.4 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Tubulin PF00091.23 001135386.1_43524001_1 - 6.3e-60 202.6 0.0 9.9e-60 202.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001135386.1_43524001_1 - 4.4e-42 143.1 0.1 6.5e-42 142.6 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 001135386.1_43524001_1 - 0.0097 15.5 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.4 001135386.1_43524001_1 - 0.022 13.8 0.0 0.042 12.9 0.0 1.4 1 0 0 1 1 1 0 Tubulin like Lipocalin PF00061.21 001082708.1_37922001_3 - 2.5e-36 124.9 0.0 3e-36 124.6 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Triabin PF03973.11 001082708.1_37922001_3 - 0.15 11.8 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Triabin RPE65 PF03055.13 001159755.1_39524001_1 - 1.1e-91 308.0 0.0 1.2e-91 307.8 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein PPARgamma_N PF12577.6 001113176.1_22424001_1 - 2.1e-32 111.5 0.9 7.1e-32 109.8 1.3 1.8 2 0 0 2 2 2 1 PPAR gamma N-terminal region zf-C4 PF00105.16 001113176.1_22424001_1 - 2.3e-27 95.1 15.0 3.7e-27 94.4 15.0 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001113176.1_22424001_1 - 1.8e-15 56.9 0.1 5.3e-15 55.4 0.1 1.6 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Tmemb_55A PF09788.7 001113176.1_22424001_1 - 0.034 13.1 3.4 0.053 12.5 3.4 1.2 1 0 0 1 1 1 0 Transmembrane protein 55A Bax1-I PF01027.18 001009245.1_39524001_1 - 2.6e-22 79.6 13.8 2e-20 73.4 9.4 2.1 2 0 0 2 2 2 2 Inhibitor of apoptosis-promoting Bax1 DUF5080 PF16883.3 001009245.1_39524001_1 - 0.051 13.6 3.3 0.09 12.8 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5080) DUF3413 PF11893.6 001009245.1_39524001_1 - 0.37 9.8 5.8 0.65 9.0 5.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) TMEM192 PF14802.4 001009245.1_39524001_1 - 0.91 8.4 3.8 9.4 5.1 2.8 2.3 2 1 0 2 2 2 0 TMEM192 family MgtE PF01769.14 001009245.1_39524001_1 - 2.5 8.3 8.9 0.44 10.8 4.9 1.7 2 0 0 2 2 2 0 Divalent cation transporter Bax1-I PF01027.18 001009245.1_39524001_2 - 0.00012 21.8 3.1 0.00018 21.2 3.1 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Parathyroid PF01279.15 001082719.1_37922001_1 - 9.9e-34 116.1 0.6 2.8e-33 114.6 0.6 1.8 1 0 0 1 1 1 1 Parathyroid hormone family Ras PF00071.20 001127284.1_39522001_1 - 2.5e-61 205.9 0.6 3e-61 205.6 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001127284.1_39522001_1 - 2.2e-33 114.9 0.5 3.3e-33 114.3 0.5 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001127284.1_39522001_1 - 2e-14 53.3 0.1 2.5e-14 53.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001127284.1_39522001_1 - 4.9e-06 26.0 0.0 7.4e-05 22.1 0.0 2.0 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 001127284.1_39522001_1 - 8.7e-05 22.4 0.1 0.00028 20.8 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001127284.1_39522001_1 - 0.00085 18.6 0.0 0.0011 18.2 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001127284.1_39522001_1 - 0.00093 18.7 0.0 0.0038 16.7 0.0 1.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.4 001127284.1_39522001_1 - 0.015 14.9 0.4 0.036 13.7 0.4 1.8 1 1 0 1 1 1 0 AAA domain DUF2757 PF10955.6 001127284.1_39522001_1 - 0.023 14.8 0.1 0.049 13.8 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2757) FeoB_N PF02421.16 001127284.1_39522001_1 - 0.034 13.5 0.0 1.4 8.3 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_16 PF13191.4 001127284.1_39522001_1 - 0.034 14.4 0.0 0.06 13.6 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.14 001127284.1_39522001_1 - 0.051 13.3 0.0 5.6 6.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 G-alpha PF00503.18 001127284.1_39522001_1 - 0.064 12.3 0.5 5.4 5.9 0.0 2.8 1 1 1 2 2 2 0 G-protein alpha subunit Septin PF00735.16 001127284.1_39522001_1 - 0.078 12.1 0.0 0.9 8.6 0.0 2.2 2 0 0 2 2 2 0 Septin Takusan PF04822.11 001011701.1_45722001_1 - 1.1e-25 89.1 5.9 1.1e-25 89.1 5.9 2.5 3 0 0 3 3 3 1 Takusan DUF616 PF04765.11 001011701.1_45722001_1 - 0.00014 21.1 0.2 0.00022 20.5 0.2 1.2 1 1 0 1 1 1 1 Protein of unknown function (DUF616) Seryl_tRNA_N PF02403.20 001011701.1_45722001_1 - 0.0021 18.1 10.0 0.12 12.5 1.8 2.2 2 0 0 2 2 2 2 Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 PF07926.10 001011701.1_45722001_1 - 0.0055 16.6 6.1 0.77 9.7 0.1 2.2 2 0 0 2 2 2 2 TPR/MLP1/MLP2-like protein DUF4164 PF13747.4 001011701.1_45722001_1 - 0.067 13.3 3.7 2.5 8.3 1.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) Phage_HK97_TLTM PF06120.9 001011701.1_45722001_1 - 0.49 9.4 8.3 0.077 12.0 2.7 1.9 1 1 1 2 2 2 0 Tail length tape measure protein DUF972 PF06156.11 001011701.1_45722001_1 - 1.1 9.8 16.9 0.99 9.9 2.6 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF972) DUF4200 PF13863.4 001011701.1_45722001_1 - 1.9 8.8 16.8 3.2 8.0 1.7 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) FtsL PF04999.11 001011701.1_45722001_1 - 4.6 7.2 9.5 0.18 11.7 1.8 2.4 2 1 1 3 3 3 0 Cell division protein FtsL LysM PF01476.18 022625.2_45726001_1 - 1.8e-34 117.4 6.5 7.1e-14 51.5 0.2 3.3 3 0 0 3 3 3 3 LysM domain Glucosaminidase PF01832.18 022625.2_45726001_1 - 1.5e-07 31.7 0.0 2.6e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase BRCA-2_OB1 PF09103.8 022625.2_45726001_1 - 0.007 16.1 0.2 1.8 8.3 0.1 3.0 1 1 1 2 2 2 2 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 CPSase_L_D2 PF02786.15 022625.2_45726001_2 - 1.3e-54 184.8 0.0 2.4e-54 183.9 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.20 022625.2_45726001_2 - 3.7e-43 146.4 0.4 8.5e-43 145.2 0.4 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain LysM PF01476.18 022625.2_45726001_2 - 5e-31 106.4 1.1 3.5e-14 52.5 0.1 2.8 2 0 0 2 2 2 2 LysM domain ATPgrasp_Ter PF15632.4 022625.2_45726001_2 - 9.9e-09 34.2 0.0 1.8e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.11 022625.2_45726001_2 - 1.8e-06 27.5 0.0 3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus OapA PF04225.10 022625.2_45726001_2 - 3.2e-05 23.8 2.1 0.081 12.9 0.3 2.4 2 0 0 2 2 2 2 Opacity-associated protein A LysM-like domain Biotin_lipoyl PF00364.20 022625.2_45726001_3 - 9.6e-16 57.3 0.1 2.4e-15 56.0 0.1 1.6 2 0 0 2 2 2 1 Biotin-requiring enzyme LysM PF01476.18 022625.2_45726001_3 - 0.00062 19.7 0.0 0.0031 17.5 0.0 2.2 2 0 0 2 2 2 1 LysM domain Biotin_lipoyl_2 PF13533.4 022625.2_45726001_3 - 0.00086 19.0 0.1 0.0082 15.8 0.1 2.2 2 0 0 2 2 2 1 Biotin-lipoyl like CCDC71L PF15374.4 001160429.1_22423001_1 - 0.021 14.0 0.0 0.025 13.7 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L 7tm_3 PF00003.20 001133105.1_43527001_2 - 1.9e-37 129.2 21.9 3.4e-37 128.3 21.9 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Septin PF00735.16 001135406.1_43527001_2 - 1.5e-126 421.3 0.2 1.9e-126 420.9 0.2 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 001135406.1_43527001_2 - 4.1e-07 30.0 0.0 8.8e-07 28.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001135406.1_43527001_2 - 4.9e-05 23.2 0.2 0.0037 17.0 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001135406.1_43527001_2 - 5.4e-05 22.7 0.1 0.013 14.9 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.14 001135406.1_43527001_2 - 0.0011 18.3 0.0 0.0022 17.2 0.0 1.5 1 0 0 1 1 1 1 AIG1 family Ras PF00071.20 001135406.1_43527001_2 - 0.0033 16.9 0.0 0.0058 16.1 0.0 1.3 1 0 0 1 1 1 1 Ras family Dynamin_N PF00350.21 001135406.1_43527001_2 - 0.0051 16.8 0.1 0.31 10.9 0.0 2.5 1 1 1 2 2 2 1 Dynamin family AAA_16 PF13191.4 001135406.1_43527001_2 - 0.025 14.8 0.0 0.061 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Roc PF08477.11 001135406.1_43527001_2 - 0.025 14.7 0.0 0.047 13.8 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.4 001135406.1_43527001_2 - 0.037 14.2 0.0 0.12 12.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.4 001135406.1_43527001_2 - 0.05 13.2 0.0 0.092 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.25 001135406.1_43527001_2 - 0.052 13.9 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Interferon PF00143.17 001031829.1_22422001_1 - 2.7e-57 193.3 0.2 3e-57 193.1 0.2 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain DUF1510 PF07423.9 001132705.1_43526001_1 - 3.6e-05 23.2 20.1 4.9e-05 22.8 20.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) Zip PF02535.20 001132705.1_43526001_1 - 0.16 11.0 13.4 0.23 10.5 13.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Ig_3 PF13927.4 001132705.1_43526001_2 - 6.4e-17 61.8 0.1 0.00011 22.7 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 001132705.1_43526001_2 - 2.2e-13 50.0 0.1 2.6e-05 24.1 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.4 001132705.1_43526001_2 - 2.4e-13 50.1 2.0 0.00032 20.8 0.1 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 001132705.1_43526001_2 - 1.6e-08 34.5 17.6 0.0017 18.4 0.0 4.2 4 1 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 001132705.1_43526001_2 - 0.19 11.7 16.5 0.36 10.9 0.0 4.5 4 1 0 4 4 4 0 Immunoglobulin V-set domain DDHD PF02862.15 001132705.1_43526001_3 - 8 6.4 21.7 12 5.8 21.7 1.2 1 0 0 1 1 1 0 DDHD domain KRTAP PF11759.6 001160289.1_37921001_1 - 6.4e-05 23.3 78.4 0.021 15.2 78.4 2.1 1 1 0 1 1 1 1 Keratin-associated matrix Trypsin PF00089.24 001242706.1_37622001_1 - 1.1e-53 182.2 0.0 1.3e-53 182.0 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001242706.1_37622001_1 - 6.7e-05 23.7 0.1 0.00011 22.9 0.1 1.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain Defensin_beta_2 PF13841.4 001040641.1_49821001_2 - 1.2e-08 35.1 13.3 1.9e-08 34.5 13.3 1.3 1 0 0 1 1 1 1 Beta defensin GST_N PF02798.18 001114766.1_39522001_1 - 1e-20 73.7 0.0 2.5e-20 72.5 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001114766.1_39522001_1 - 1.8e-20 72.8 0.0 3.3e-20 72.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 001114766.1_39522001_1 - 2.1e-20 72.6 0.0 3.4e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001114766.1_39522001_1 - 0.004 17.4 0.1 0.012 15.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 001114766.1_39522001_1 - 0.044 13.6 0.0 0.076 12.8 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain IL2 PF00715.15 001172837.1_09922001_1 - 7e-67 223.7 3.3 8.2e-67 223.5 3.3 1.0 1 0 0 1 1 1 1 Interleukin 2 Prot_inhib_II PF02428.13 001172837.1_09922001_3 - 0.28 11.5 6.1 0.11 12.8 1.6 2.1 2 0 0 2 2 2 0 Potato type II proteinase inhibitor family AA_permease_2 PF13520.4 001025639.1_45726001_1 - 3.9e-46 157.6 21.0 3.9e-46 157.6 21.0 2.3 2 0 0 2 2 2 1 Amino acid permease AA_permease PF00324.19 001025639.1_45726001_1 - 4.4e-29 101.3 23.6 4.4e-29 101.3 23.6 2.2 3 0 0 3 3 3 1 Amino acid permease AA_permease_C PF13906.4 001025639.1_45726001_1 - 6.5e-25 86.8 7.1 6.5e-25 86.8 7.1 2.9 3 0 0 3 3 3 1 C-terminus of AA_permease DUF2157 PF09925.7 001025639.1_45726001_1 - 0.0035 17.0 9.5 0.0085 15.8 0.0 3.5 3 2 1 4 4 4 1 Predicted membrane protein (DUF2157) Strabismus PF06638.9 001025639.1_45726001_1 - 0.83 8.1 7.3 1.5 7.3 7.3 1.3 1 0 0 1 1 1 0 Strabismus protein Sulfotransfer_1 PF00685.25 001127619.1_37623001_1 - 1.6e-85 286.7 0.0 1.9e-85 286.4 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001127619.1_37623001_1 - 5.4e-08 33.4 0.0 3.4e-05 24.2 0.1 2.3 1 1 0 2 2 2 2 Sulfotransferase family Gln-synt_C PF00120.22 001173087.1_09924001_2 - 3.3e-72 243.3 0.0 5.1e-72 242.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.17 001173087.1_09924001_2 - 3.1e-07 29.9 0.7 9.8e-06 25.1 0.1 2.3 2 0 0 2 2 2 1 Glutamine synthetase, beta-Grasp domain Gln-synt_N_2 PF16952.3 001173087.1_09924001_2 - 1.5e-05 24.6 0.0 3.2e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase N-terminal domain Band_3_cyto PF07565.11 001173087.1_09924001_2 - 0.13 11.9 5.2 0.2 11.3 5.2 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain RasGEF PF00617.17 001082381.1_37926001_3 - 1.2e-43 149.2 0.2 2.1e-43 148.3 0.2 1.4 1 0 0 1 1 1 1 RasGEF domain ubiquitin PF00240.21 001082381.1_37926001_3 - 1.7e-20 72.4 0.2 3.1e-20 71.6 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.29 001082381.1_37926001_3 - 4.4e-14 51.9 0.2 9.8e-14 50.8 0.2 1.6 1 0 0 1 1 1 1 UBA/TS-N domain XPC-binding PF09280.9 001082381.1_37926001_3 - 3e-10 39.6 6.9 8.1e-10 38.2 6.9 1.7 1 0 0 1 1 1 1 XPC-binding domain Rad60-SLD PF11976.6 001082381.1_37926001_3 - 0.00027 20.6 0.7 0.00045 19.9 0.7 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.4 001082381.1_37926001_3 - 0.0066 16.4 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.8 001082381.1_37926001_3 - 0.11 12.2 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain 7tm_1 PF00001.19 001127625.1_37623001_1 - 7.8e-38 130.1 10.9 1e-37 129.7 10.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001127625.1_37623001_1 - 2.5e-05 23.6 0.8 2.5e-05 23.6 0.8 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srt PF10321.7 001127625.1_37623001_1 - 0.00013 20.9 14.4 0.0085 14.9 2.8 2.5 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srt 7TM_GPCR_Srv PF10323.7 001127625.1_37623001_1 - 0.0002 20.6 9.2 0.00047 19.5 8.7 1.7 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv Cytochrom_B_N_2 PF13631.4 001127625.1_37623001_1 - 0.00077 19.4 2.0 0.002 18.0 0.1 2.3 2 1 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB 7TM_GPCR_Srsx PF10320.7 001127625.1_37623001_1 - 0.0027 17.0 8.7 0.091 12.0 2.7 2.3 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001127625.1_37623001_1 - 0.0087 15.7 8.7 0.1 12.2 8.7 2.0 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001127625.1_37623001_1 - 0.059 12.5 14.2 0.32 10.1 14.2 2.2 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF3487 PF11990.6 001127625.1_37623001_1 - 1.6 8.5 0.0 1.6 8.5 0.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3487) 7TM_GPCR_Sru PF10322.7 001127625.1_37623001_1 - 1.9 7.6 13.0 0.035 13.3 3.3 2.3 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sru DUF4190 PF13828.4 001127625.1_37623001_1 - 7.1 6.3 8.1 0.49 10.1 1.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4190) PMP22_Claudin PF00822.18 001159778.1_49823001_2 - 4.1e-18 65.7 0.0 5.2e-18 65.3 0.0 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001159778.1_49823001_2 - 0.00017 21.3 11.1 0.00051 19.7 6.0 2.5 2 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction DUF1282 PF06930.10 001159778.1_49823001_2 - 0.0099 15.6 0.6 0.016 14.9 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1282) Clc-like PF07062.10 001159778.1_49823001_2 - 0.049 13.0 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Clc-like DUF872 PF05915.10 001159778.1_49823001_2 - 0.35 11.0 2.1 0.41 10.8 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) 7tm_1 PF00001.19 001127626.1_37623001_1 - 5.2e-42 143.8 12.9 6.4e-42 143.5 12.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001127626.1_37623001_1 - 4.8e-07 29.3 13.2 8.4e-07 28.5 13.2 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv TAS2R PF05296.11 001127626.1_37623001_1 - 3.1e-06 26.4 10.2 0.0042 16.1 3.6 2.1 2 0 0 2 2 2 2 Taste receptor protein (TAS2R) 7TM_GPCR_Srw PF10324.7 001127626.1_37623001_1 - 1.4e-05 24.5 16.4 0.00013 21.3 16.4 2.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.7 001127626.1_37623001_1 - 2.4e-05 23.7 17.0 7.6e-05 22.1 17.0 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001127626.1_37623001_1 - 0.00093 18.5 14.8 0.0018 17.5 14.8 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF4407 PF14362.4 001127626.1_37623001_1 - 0.26 10.5 4.1 0.42 9.8 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) FA_desaturase PF00487.22 001127626.1_37623001_1 - 3.2 7.4 10.4 0.3 10.7 0.4 2.4 2 1 0 2 2 2 0 Fatty acid desaturase DUF2417 PF10329.7 001127626.1_37623001_1 - 3.6 6.8 7.8 0.58 9.4 2.8 2.0 2 0 0 2 2 2 0 Region of unknown function (DUF2417) DUF3810 PF12725.5 001202461.1_49822001_1 - 0.041 13.1 1.0 0.056 12.7 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) zf-CCCH PF00642.22 001132015.1_43529001_2 - 1.1e-09 37.8 24.5 0.00014 21.6 1.5 3.8 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 001132015.1_43529001_2 - 0.00013 22.1 22.5 0.018 15.4 2.2 4.0 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger Torus PF16131.3 001132015.1_43529001_2 - 0.00038 21.0 23.6 0.0042 17.6 2.1 4.0 2 1 2 4 4 4 3 Torus domain zf-CCCH_3 PF15663.3 001132015.1_43529001_2 - 0.0026 17.9 8.1 0.0026 17.9 8.1 3.0 2 1 1 3 3 3 1 Zinc-finger containing family Ribosomal_S8e PF01201.20 001013928.2_45722001_1 - 4.5e-58 195.1 0.8 5.8e-58 194.8 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e Myosin_head PF00063.19 001009221.1_22429001_2 - 7.5e-282 936.4 1.5 7.5e-282 936.4 1.5 3.3 4 0 0 4 4 4 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 001009221.1_22429001_2 - 2.2e-162 542.2 259.3 2.7e-162 542.0 259.3 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 001009221.1_22429001_2 - 7.7e-18 63.9 3.5 2.4e-17 62.3 3.5 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 001009221.1_22429001_2 - 0.00044 19.6 5.1 0.00044 19.6 5.1 9.3 1 1 6 9 9 9 5 Reovirus sigma C capsid protein DUF1850 PF08905.9 001009221.1_22429001_2 - 0.028 14.6 0.2 0.1 12.8 0.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1850) IQ PF00612.25 001009221.1_22429001_2 - 0.042 13.5 0.5 0.29 10.9 0.1 2.7 3 0 0 3 3 3 0 IQ calmodulin-binding motif Filament PF00038.19 001009221.1_22429001_2 - 0.077 12.4 223.3 0.015 14.8 19.0 10.3 1 1 8 9 9 9 0 Intermediate filament protein AAA_16 PF13191.4 001009221.1_22429001_2 - 0.59 10.3 0.0 0.59 10.3 0.0 6.0 3 2 0 4 4 4 0 AAA ATPase domain p450 PF00067.20 001127630.1_29623001_1 - 8.9e-117 390.5 1.0 1.1e-116 390.2 1.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CDT1_C PF16679.3 001127630.1_29623001_1 - 0.045 14.0 0.4 0.11 12.8 0.4 1.6 1 0 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain Prominin PF05478.9 001242722.1_37626001_1 - 6.9e-266 884.1 10.4 7.9e-266 883.9 10.4 1.0 1 0 0 1 1 1 1 Prominin DUF2207 PF09972.7 001242722.1_37626001_1 - 8.6e-05 21.4 0.6 0.0041 15.8 0.1 2.8 3 0 0 3 3 3 1 Predicted membrane protein (DUF2207) Tweety PF04906.11 001242722.1_37626001_1 - 0.00091 17.9 17.4 0.0099 14.4 0.3 3.4 2 1 0 3 3 3 2 Tweety Ribonuc_L-PSP PF01042.19 001242722.1_37626001_1 - 0.052 13.4 0.1 0.27 11.1 0.0 2.2 2 0 0 2 2 2 0 Endoribonuclease L-PSP Reo_sigmaC PF04582.10 001242722.1_37626001_1 - 0.49 9.6 11.6 4.5 6.5 7.9 2.6 2 1 0 2 2 2 0 Reovirus sigma C capsid protein Snapin_Pallidin PF14712.4 001242722.1_37626001_1 - 0.76 10.1 4.5 11 6.5 0.2 2.9 2 0 0 2 2 2 0 Snapin/Pallidin Prefoldin PF02996.15 001242722.1_37626001_1 - 0.82 9.5 7.7 18 5.2 0.5 3.6 3 0 0 3 3 3 0 Prefoldin subunit DUF1664 PF07889.10 001242722.1_37626001_1 - 4.5 7.1 10.4 11 5.9 1.1 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) SNARE PF05739.17 001242722.1_37626001_1 - 8.5 6.3 7.1 43 4.1 7.1 2.3 1 0 0 1 1 1 0 SNARE domain WD40 PF00400.30 001243647.1_49823001_1 - 5.5e-20 71.2 12.1 0.00014 22.5 0.2 6.4 7 0 0 7 7 7 5 WD domain, G-beta repeat FYVE PF01363.19 001243647.1_49823001_1 - 1.6e-14 53.6 7.4 4e-14 52.4 7.4 1.7 1 0 0 1 1 1 1 FYVE zinc finger ANAPC4_WD40 PF12894.5 001243647.1_49823001_1 - 6.5e-05 23.0 0.2 0.5 10.6 0.0 3.4 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain ELYS-bb PF16687.3 001243647.1_49823001_1 - 0.016 13.7 0.0 0.025 13.1 0.0 1.2 1 0 0 1 1 1 0 beta-propeller of ELYS nucleoporin IBR PF01485.19 001243647.1_49823001_1 - 2.8 8.1 12.2 9 6.5 0.6 2.7 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-B_box PF00643.22 001243647.1_49823001_1 - 6.4 6.9 11.8 0.18 11.8 1.4 3.1 3 0 0 3 3 3 0 B-box zinc finger Pap_E4 PF02711.12 001107967.2_45723001_3 - 3.1 8.7 8.7 0.57 11.1 3.3 2.3 1 1 1 2 2 2 0 E4 protein CLZ PF16526.3 001143663.1_39525001_1 - 9.1e-30 102.7 5.9 9.1e-30 102.7 5.9 2.2 2 0 0 2 2 2 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Ion_trans PF00520.29 001143663.1_39525001_1 - 8.9e-25 87.2 7.3 1.4e-24 86.6 7.3 1.2 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.27 001143663.1_39525001_1 - 2.2e-18 65.9 0.0 3.7e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.14 001143663.1_39525001_1 - 0.014 15.2 2.8 0.046 13.6 2.8 2.0 1 0 0 1 1 1 0 Ion channel Ferlin_C PF16165.3 001143663.1_39525001_1 - 0.077 12.8 2.4 0.18 11.6 2.4 1.6 1 0 0 1 1 1 0 Ferlin C-terminus FlaC_arch PF05377.9 001143663.1_39525001_1 - 0.18 12.1 1.6 1.5 9.1 0.3 2.6 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF948 PF06103.9 001143663.1_39525001_1 - 0.24 11.5 1.6 7.2 6.8 0.2 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Shisa PF13908.4 001143663.1_39525001_1 - 0.28 11.3 0.9 0.39 10.8 0.0 1.7 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator FAM76 PF16046.3 001143663.1_39525001_1 - 0.95 8.6 7.5 0.36 10.0 0.5 2.3 2 0 0 2 2 2 0 FAM76 protein SKA1 PF07160.10 001143663.1_39525001_1 - 9.9 5.8 11.9 1.4 8.6 0.7 2.6 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 1 RRXRR PF14239.4 001143663.1_39525001_2 - 3.9 7.2 11.0 7.1 6.3 11.0 1.3 1 0 0 1 1 1 0 RRXRR protein IDO PF01231.16 001242724.1_37623001_1 - 1e-121 406.6 0.0 1.3e-121 406.3 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase cNMP_binding PF00027.27 001143664.1_39525001_1 - 6.8e-18 64.4 0.1 1.2e-17 63.6 0.1 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DUF3915 PF13054.4 001143664.1_39525001_1 - 2.2 8.2 5.2 0.98 9.3 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3915) AT_hook PF02178.17 001195341.1_49821001_1 - 0.052 13.3 36.1 0.11 12.3 5.6 4.2 4 0 0 4 4 4 0 AT hook motif DUF4733 PF15878.3 001195341.1_49821001_2 - 0.11 12.8 3.0 0.18 12.2 3.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4733) Ly49 PF08391.8 001009498.1_45722001_1 - 1.6e-55 186.4 2.9 3.6e-55 185.3 2.9 1.6 1 0 0 1 1 1 1 Ly49-like protein, N-terminal region Lectin_C PF00059.19 001009498.1_45722001_1 - 2.2e-14 54.0 5.7 4.6e-14 52.9 5.7 1.6 1 0 0 1 1 1 1 Lectin C-type domain Insulin PF00049.16 001122686.1_32322001_1 - 3.3e-12 47.1 0.0 6.9e-12 46.1 0.0 1.5 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 001122686.1_32322001_1 - 0.001 18.9 9.2 0.084 12.8 3.7 2.3 2 0 0 2 2 2 2 Nematode insulin-related peptide beta type Hepcidin PF06446.10 001122686.1_32322001_1 - 0.015 15.6 0.6 0.027 14.7 0.6 1.6 1 0 0 1 1 1 0 Hepcidin Interferon PF00143.17 001102440.1_22422001_1 - 1.8e-53 180.8 0.0 2.1e-53 180.7 0.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Insulin PF00049.16 001122687.1_37622001_1 - 1.8e-08 35.1 0.1 4.5e-08 33.9 0.1 1.6 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 001122687.1_37622001_1 - 0.00031 20.5 6.6 0.059 13.3 1.6 2.2 2 0 0 2 2 2 2 Nematode insulin-related peptide beta type Interferon PF00143.17 001048202.1_22422001_1 - 4.9e-56 189.2 0.0 5.5e-56 189.0 0.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Insulin PF00049.16 001122688.1_37621001_1 - 5.3e-08 33.6 3.4 2.8e-07 31.3 3.4 1.9 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 001122688.1_37621001_1 - 0.045 13.6 3.3 4.7 7.2 0.1 2.5 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type Cofilin_ADF PF00241.18 001082149.1_37925001_1 - 1.3e-17 64.0 0.0 2.6e-17 63.0 0.0 1.5 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein CAF-1_p150 PF11600.6 001082149.1_37925001_1 - 0.049 13.2 36.1 0.097 12.2 36.1 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal CRT10 PF08728.8 001082149.1_37925001_1 - 0.86 7.6 3.5 1.1 7.2 3.5 1.1 1 0 0 1 1 1 0 CRT10 ABC_membrane PF00664.21 001009790.1_39528001_1 - 4.2e-169 561.1 33.6 3.1e-92 309.0 12.0 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001009790.1_39528001_1 - 1.7e-75 251.9 0.5 8.6e-37 126.6 0.1 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 001009790.1_39528001_1 - 2e-15 56.7 3.5 2.1e-07 30.5 0.0 3.8 2 2 2 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 001009790.1_39528001_1 - 4.4e-10 40.1 1.2 0.0011 19.2 0.1 3.0 2 2 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.7 001009790.1_39528001_1 - 3.3e-09 35.9 0.8 0.0006 18.6 0.0 2.9 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_22 PF13401.4 001009790.1_39528001_1 - 3.3e-08 33.7 1.1 0.0065 16.6 0.1 3.2 2 2 0 2 2 2 2 AAA domain Zeta_toxin PF06414.10 001009790.1_39528001_1 - 4.2e-08 32.6 1.1 0.00069 18.8 0.0 3.4 4 0 0 4 4 3 2 Zeta toxin DUF258 PF03193.14 001009790.1_39528001_1 - 3.2e-07 30.3 0.1 0.028 14.2 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 G-alpha PF00503.18 001009790.1_39528001_1 - 3.2e-07 29.7 0.0 0.004 16.2 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit AAA PF00004.27 001009790.1_39528001_1 - 5.2e-07 30.0 3.3 0.06 13.6 0.1 4.2 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 001009790.1_39528001_1 - 5.9e-06 26.2 0.4 0.2 11.5 0.0 3.7 3 1 1 4 4 4 2 AAA domain (dynein-related subfamily) Rad17 PF03215.13 001009790.1_39528001_1 - 8.2e-06 24.9 0.1 0.009 14.8 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_29 PF13555.4 001009790.1_39528001_1 - 8.4e-06 25.3 1.7 0.079 12.6 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_14 PF13173.4 001009790.1_39528001_1 - 1.3e-05 25.1 0.1 0.0073 16.2 0.0 3.6 3 1 0 3 3 3 1 AAA domain AAA_15 PF13175.4 001009790.1_39528001_1 - 0.00012 21.7 0.0 0.094 12.2 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.4 001009790.1_39528001_1 - 0.00021 20.9 2.2 0.28 10.7 0.2 3.0 2 1 0 2 2 2 2 AAA domain DUF815 PF05673.11 001009790.1_39528001_1 - 0.00047 19.3 0.1 0.3 10.1 0.0 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF815) PRK PF00485.16 001009790.1_39528001_1 - 0.00048 19.8 0.1 0.75 9.4 0.0 2.6 2 1 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family APS_kinase PF01583.18 001009790.1_39528001_1 - 0.00059 19.6 0.2 0.64 9.8 0.0 2.5 2 0 0 2 2 2 2 Adenylylsulphate kinase ATP-synt_ab PF00006.23 001009790.1_39528001_1 - 0.001 18.7 1.2 1.8 8.1 0.0 3.0 2 1 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.4 001009790.1_39528001_1 - 0.0011 18.6 0.1 0.55 9.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.20 001009790.1_39528001_1 - 0.0014 18.9 0.0 4.1 7.7 0.0 3.1 3 0 0 3 3 2 0 RNA helicase AAA_28 PF13521.4 001009790.1_39528001_1 - 0.0018 18.4 0.0 4.4 7.4 0.1 3.3 2 1 1 3 3 3 0 AAA domain SbcCD_C PF13558.4 001009790.1_39528001_1 - 0.0033 17.5 2.6 0.59 10.3 0.3 3.8 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit ArgK PF03308.14 001009790.1_39528001_1 - 0.0056 15.6 0.1 0.74 8.6 0.0 2.5 2 0 0 2 2 2 1 ArgK protein DUF87 PF01935.15 001009790.1_39528001_1 - 0.0057 16.6 2.4 3.2 7.6 0.1 3.0 3 0 0 3 3 3 2 Domain of unknown function DUF87 AAA_33 PF13671.4 001009790.1_39528001_1 - 0.0079 16.2 0.0 4.5 7.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.4 001009790.1_39528001_1 - 0.014 15.1 0.1 9 5.9 0.0 3.7 3 1 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system tRNA_lig_kinase PF08303.9 001009790.1_39528001_1 - 0.016 15.2 0.0 7.6 6.5 0.0 2.6 2 0 0 2 2 2 0 tRNA ligase kinase domain AAA_18 PF13238.4 001009790.1_39528001_1 - 0.017 15.5 0.0 5.4 7.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.10 001009790.1_39528001_1 - 0.02 14.7 0.2 6.7 6.5 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.4 001009790.1_39528001_1 - 0.021 14.3 0.5 3.3 7.1 0.0 2.8 3 0 0 3 3 3 0 AAA domain DUF3579 PF12112.6 001009790.1_39528001_1 - 0.032 14.6 0.1 0.58 10.6 0.0 2.9 3 0 0 3 3 2 0 Protein of unknown function (DUF3579) DUF2207 PF09972.7 001009790.1_39528001_1 - 0.032 12.9 0.0 0.032 12.9 0.0 3.6 4 0 0 4 4 4 0 Predicted membrane protein (DUF2207) Mg_chelatase PF01078.19 001009790.1_39528001_1 - 0.037 13.3 0.0 8.4 5.6 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.15 001009790.1_39528001_1 - 0.041 13.5 1.5 44 3.6 0.0 3.9 4 0 0 4 4 4 0 IstB-like ATP binding protein PduV-EutP PF10662.7 001009790.1_39528001_1 - 0.068 12.8 2.8 24 4.5 0.0 4.0 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.21 001009790.1_39528001_1 - 0.12 12.3 0.0 17 5.4 0.0 2.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase NB-ARC PF00931.20 001009790.1_39528001_1 - 0.14 11.0 1.1 10 4.9 0.1 2.3 2 0 0 2 2 2 0 NB-ARC domain Halogen_Hydrol PF10112.7 001009790.1_39528001_1 - 4.8 7.0 7.7 1.8 8.4 2.5 2.9 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DUF3487 PF11990.6 001009790.1_39528001_1 - 5.4 6.8 6.8 3.6 7.4 0.5 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) Interferon PF00143.17 001089305.1_22422001_1 - 5.7e-55 185.7 0.0 6.5e-55 185.6 0.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain HSF_DNA-bind PF00447.15 001012132.1_45723001_2 - 5.8e-21 74.8 0.5 1.2e-20 73.8 0.5 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding DUF2063 PF09836.7 001012132.1_45723001_2 - 0.13 12.4 0.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Putative DNA-binding domain Cementoin PF10511.7 001173035.1_09929001_2 - 8.7e-103 331.5 393.5 2.9e-06 26.8 2.1 64.5 61 11 8 71 71 71 39 Trappin protein transglutaminase binding domain WAP PF00095.19 001173035.1_09929001_2 - 1.1e-06 28.8 15.8 1.9e-06 28.0 15.8 1.4 1 0 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' DUF1474 PF07342.9 001173035.1_09929001_2 - 0.16 12.2 0.0 1 9.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1474) DUF3645 PF12359.6 001173035.1_09929001_3 - 0.1 11.9 1.2 1.2e+02 2.1 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3645) Noggin PF05806.10 001174110.1_39522001_1 - 7.3e-101 336.4 0.1 8.4e-101 336.2 0.1 1.0 1 0 0 1 1 1 1 Noggin Cluap1 PF10234.7 001245000.1_49825001_3 - 1.9e-116 388.1 10.5 2.6e-116 387.6 10.5 1.2 1 0 0 1 1 1 1 Clusterin-associated protein-1 SseC PF04888.10 001245000.1_49825001_3 - 0.087 12.2 3.2 0.13 11.7 3.2 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family SLY PF12485.6 001245000.1_49825001_3 - 0.12 13.0 2.7 0.22 12.1 2.7 1.4 1 0 0 1 1 1 0 Lymphocyte signaling adaptor protein TFIIA PF03153.11 001245000.1_49825001_3 - 0.59 9.9 11.2 0.77 9.5 11.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RasGAP_C PF03836.13 001245000.1_49825001_3 - 1.1 9.3 11.0 2.4 8.2 10.7 1.7 1 1 0 1 1 1 0 RasGAP C-terminus Apolipo_F PF15148.4 001133869.1_43524001_1 - 7e-66 221.4 1.0 1.6e-58 197.4 0.0 2.1 1 1 1 2 2 2 2 Apolipoprotein F 7tm_1 PF00001.19 001246237.1_39523001_1 - 9.9e-49 165.8 6.9 1.2e-48 165.6 6.9 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001246237.1_39523001_1 - 1.1e-06 28.1 1.2 1.6e-06 27.6 1.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001246237.1_39523001_1 - 7.1e-06 25.8 0.3 1.3e-05 25.0 0.3 1.4 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srv PF10323.7 001246237.1_39523001_1 - 7.5e-05 22.1 0.0 0.00017 20.9 0.0 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv DUF1856 PF08983.8 001246237.1_39523001_1 - 0.0023 18.1 2.8 0.0054 16.9 2.8 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1856) Srg PF02118.19 001246237.1_39523001_1 - 0.0027 17.3 0.9 0.0027 17.3 0.9 1.5 2 0 0 2 2 2 1 Srg family chemoreceptor PTCRA PF15028.4 001246237.1_39523001_1 - 0.073 12.6 0.2 1.2 8.7 0.1 2.3 2 0 0 2 2 2 0 Pre-T-cell antigen receptor DUF5134 PF17197.2 001246237.1_39523001_1 - 1.8 8.3 6.3 3.5 7.4 4.6 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5134) Ras PF00071.20 001123175.1_49822001_1 - 8.4e-40 135.9 0.0 1.1e-39 135.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001123175.1_49822001_1 - 4.2e-27 94.6 0.1 6.8e-27 94.0 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001123175.1_49822001_1 - 1.1e-12 47.6 0.0 1.5e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001123175.1_49822001_1 - 6.4e-06 25.6 0.0 8.3e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.7 001123175.1_49822001_1 - 0.028 14.1 0.1 0.068 12.8 0.1 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.18 001123175.1_49822001_1 - 0.074 12.1 0.6 0.19 10.7 0.2 1.9 1 1 1 2 2 2 0 G-protein alpha subunit DLIC PF05783.9 001123175.1_49822001_1 - 0.1 11.2 0.2 0.52 8.9 0.1 1.9 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) Fibrinogen_C PF00147.16 001104934.1_39523001_1 - 0.00031 20.5 0.6 0.00051 19.8 0.6 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain MAGE_N PF12440.6 001009262.1_22424001_1 - 1e-23 83.7 24.2 1.9e-23 82.8 24.2 1.5 1 0 0 1 1 1 1 Melanoma associated antigen family N terminal MAGE PF01454.17 001009262.1_22424001_1 - 3.4e-10 39.9 2.3 5e-07 29.5 0.0 2.6 2 1 1 3 3 3 2 MAGE family Trypsin PF00089.24 001172888.1_09922001_1 - 1.4e-81 273.4 8.6 1.5e-81 273.3 8.6 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001172888.1_09922001_1 - 2.5e-05 25.0 0.3 4.3e-05 24.3 0.3 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001172888.1_09922001_1 - 0.043 14.1 0.1 0.091 13.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Interferon PF00143.17 001195377.1_49822001_1 - 1.3e-67 226.9 0.5 1.4e-67 226.7 0.5 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Actin PF00022.17 001013937.1_45723001_3 - 1.9e-113 379.1 0.0 3.3e-112 374.9 0.0 1.9 1 1 0 1 1 1 1 Actin 7tm_1 PF00001.19 001126347.1_39523001_1 - 4.5e-51 173.5 12.7 5.8e-51 173.1 12.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001126347.1_39523001_1 - 6e-14 51.9 4.2 7.9e-14 51.5 4.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001126347.1_39523001_1 - 6.2e-07 29.3 10.7 1.6e-06 28.0 10.7 1.7 1 1 0 1 1 1 1 Olfactory receptor Herpes_US9 PF06072.9 001126347.1_39523001_1 - 0.0099 15.6 0.5 0.066 13.0 0.5 2.4 1 0 0 1 1 1 1 Alphaherpesvirus tegument protein US9 7TM_GPCR_Srx PF10328.7 001126347.1_39523001_1 - 0.69 9.0 7.2 0.23 10.6 4.1 1.9 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF2116 PF09889.7 001126347.1_39523001_1 - 2.4 8.1 5.4 3.2 7.7 0.1 2.9 3 0 0 3 3 3 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF1003 PF06210.9 001126347.1_39523001_1 - 5.9 7.0 6.9 0.87 9.6 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) Med20 PF08612.9 001206352.1_49825001_1 - 5.3e-48 163.2 0.0 6.9e-48 162.8 0.0 1.1 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex p450 PF00067.20 001205152.1_39524001_1 - 9.8e-153 509.1 0.1 1.1e-152 508.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 MORN PF02493.18 001047912.1_45723001_1 - 4.1e-07 29.4 0.7 0.0012 18.5 0.2 2.9 2 0 0 2 2 2 2 MORN repeat MAP65_ASE1 PF03999.10 001109527.2_45726001_3 - 6.4e-12 44.8 11.4 6.4e-12 44.8 11.4 1.9 2 1 0 2 2 2 1 Microtubule associated protein (MAP65/ASE1 family) 7tm_1 PF00001.19 001039955.1_22423001_1 - 2.2e-73 246.6 0.0 2.7e-73 246.4 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001039955.1_22423001_1 - 1.9e-09 37.5 3.8 6.4e-07 29.3 1.9 2.2 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001039955.1_22423001_1 - 2.8e-07 30.0 16.2 1.4e-05 24.5 6.1 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001039955.1_22423001_1 - 1.6e-05 24.3 13.3 0.00012 21.4 6.8 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srx T2SSM PF04612.10 001039955.1_22423001_1 - 0.22 11.4 0.1 0.4 10.6 0.1 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Phosphodiest PF01663.20 001082742.2_37926001_1 - 1e-91 308.1 0.0 1.4e-91 307.7 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Somatomedin_B PF01033.15 001082742.2_37926001_1 - 3.1e-15 56.2 42.2 2.6e-08 34.0 13.4 3.1 3 0 0 3 3 3 2 Somatomedin B domain Endonuclease_NS PF01223.21 001082742.2_37926001_1 - 1.8e-09 37.6 0.0 3.1e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Sulfatase PF00884.21 001082742.2_37926001_1 - 0.00039 19.8 0.0 0.044 13.0 0.0 2.2 2 0 0 2 2 2 2 Sulfatase Metalloenzyme PF01676.16 001082742.2_37926001_1 - 0.014 14.6 0.0 0.023 13.9 0.0 1.2 1 0 0 1 1 1 0 Metalloenzyme superfamily zf-C2H2_4 PF13894.4 001082041.1_37926001_2 - 7.4e-20 69.8 43.8 0.00029 21.3 3.4 7.3 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2 PF00096.24 001082041.1_37926001_2 - 2.3e-18 65.4 46.5 9.7e-06 25.6 3.7 7.3 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001082041.1_37926001_2 - 3e-15 55.7 60.4 1.3e-05 25.3 2.8 9.0 10 0 0 10 10 9 5 Zinc-finger double domain zf-C2H2_6 PF13912.4 001082041.1_37926001_2 - 1.6e-06 27.8 38.1 0.0014 18.4 2.1 7.2 7 0 0 7 7 7 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001082041.1_37926001_2 - 9.4e-05 22.5 25.6 0.046 13.9 0.1 6.8 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001082041.1_37926001_2 - 0.016 15.5 1.1 0.016 15.5 1.1 6.7 7 0 0 7 7 7 0 Zinc-finger of C2H2 type GAGA PF09237.9 001082041.1_37926001_2 - 0.016 14.9 4.6 2 8.1 0.0 3.5 3 0 0 3 3 3 0 GAGA factor DZR PF12773.5 001082041.1_37926001_2 - 0.13 12.2 22.1 0.072 13.0 0.9 4.0 3 1 1 4 4 4 0 Double zinc ribbon FYVE PF01363.19 001082041.1_37926001_2 - 0.48 10.5 29.3 0.83 9.7 7.5 4.3 2 1 2 4 4 4 0 FYVE zinc finger Cript PF10235.7 001082041.1_37926001_2 - 1.2 9.6 17.4 2 8.9 0.6 4.0 2 1 2 4 4 4 0 Microtubule-associated protein CRIPT Prok-RING_1 PF14446.4 001082041.1_37926001_2 - 1.9 8.4 15.5 9.2 6.2 0.2 5.8 6 0 0 6 6 6 0 Prokaryotic RING finger family 1 DUF2225 PF09986.7 001082041.1_37926001_2 - 2 7.9 5.7 3.7 7.1 4.7 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) OSTMP1 PF09777.7 001082041.1_37926001_2 - 3.6 6.8 9.3 1.1 8.4 6.2 1.7 2 0 0 2 2 2 0 Osteopetrosis-associated transmembrane protein 1 precursor zf-RING_10 PF16685.3 001082041.1_37926001_2 - 3.7 7.6 12.2 0.083 12.9 2.6 2.9 3 0 0 3 3 3 0 zinc RING finger of MSL2 Zn-ribbon_8 PF09723.8 001082041.1_37926001_2 - 4.2 7.4 31.2 0.03 14.3 1.8 5.0 5 1 1 6 6 5 0 Zinc ribbon domain zf-Sec23_Sec24 PF04810.13 001082041.1_37926001_2 - 7.3 6.6 12.2 2.8 7.9 0.1 4.9 6 0 0 6 6 6 0 Sec23/Sec24 zinc finger zf-C2H2_2 PF12756.5 001082041.1_37926001_2 - 8.8 6.6 27.6 11 6.3 1.5 5.3 2 1 1 4 4 4 0 C2H2 type zinc-finger (2 copies) Pkinase PF00069.23 001123156.2_49824001_1 - 4.6e-39 134.2 0.0 6.5e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001123156.2_49824001_1 - 3.6e-33 114.8 0.0 5e-33 114.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PetN PF03742.12 001123156.2_49824001_2 - 0.16 11.7 0.1 0.16 11.7 0.1 2.6 3 0 0 3 3 3 0 PetN LIM PF00412.20 001013172.1_45724001_1 - 8.8e-36 121.8 45.6 8.6e-12 45.0 6.7 4.3 4 0 0 4 4 4 4 LIM domain Ureidogly_lyase PF04115.10 001013172.1_45724001_1 - 0.085 12.5 0.1 2.7 7.6 0.0 2.8 2 1 1 3 3 3 0 Ureidoglycolate lyase LIM PF00412.20 001013172.1_45724001_2 - 1.3e-08 34.8 8.0 1.3e-08 34.8 8.0 3.3 4 0 0 4 4 4 1 LIM domain RFamide_26RFa PF11109.6 001126369.1_39521001_1 - 6.5e-59 198.1 0.0 7.3e-59 197.9 0.0 1.0 1 0 0 1 1 1 1 Orexigenic neuropeptide Qrfp/P518 ubiquitin PF00240.21 001246228.1_22421001_1 - 9e-07 28.4 0.0 1.2e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family COesterase PF00135.26 001190369.1_45724001_2 - 3.1e-171 570.7 0.0 3.6e-171 570.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001190369.1_45724001_2 - 2.1e-09 37.4 0.3 9.5e-09 35.3 0.3 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 001190369.1_45724001_2 - 3.5e-05 23.2 0.0 6.1e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.7 001190369.1_45724001_2 - 0.039 12.7 0.0 0.065 12.0 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase LRR_4 PF12799.5 001077209.1_39523001_1 - 9.5e-10 38.4 2.6 0.04 14.2 0.1 4.8 4 1 1 5 5 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001077209.1_39523001_1 - 2.6e-08 33.3 0.5 0.005 16.4 0.1 4.6 5 0 0 5 5 5 3 Leucine rich repeat LRR_6 PF13516.4 001077209.1_39523001_1 - 0.00028 20.6 16.3 0.0036 17.1 0.1 5.6 7 0 0 7 7 7 2 Leucine Rich repeat LRR_1 PF00560.31 001077209.1_39523001_1 - 0.0036 17.4 8.5 14 6.5 0.0 5.4 5 1 0 5 5 5 3 Leucine Rich Repeat GRIN_C PF15235.4 001245975.1_49823001_1 - 5.7e-27 94.4 0.7 3.8e-26 91.7 0.7 2.2 1 1 0 1 1 1 1 G protein-regulated inducer of neurite outgrowth C-terminus 7tm_1 PF00001.19 001199793.1_39523001_1 - 1.8e-47 161.7 0.0 2.1e-47 161.5 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001199793.1_39523001_1 - 1.3e-06 27.8 0.0 1.8e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001199793.1_39523001_1 - 0.00013 21.6 0.0 0.00025 20.7 0.0 1.4 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srv PF10323.7 001199793.1_39523001_1 - 0.0042 16.4 0.0 0.009 15.2 0.0 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Git3 PF11710.6 001199793.1_39523001_1 - 0.0057 16.3 1.1 0.01 15.5 1.1 1.3 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Ribosomal_L7Ae PF01248.24 001132787.1_43527001_2 - 0.0022 17.6 0.4 0.0039 16.8 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_L7Ae PF01248.24 001132787.1_43527001_3 - 3.2e-12 45.9 0.0 5e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family 7tm_1 PF00001.19 001082226.1_37923001_1 - 2.2e-63 213.9 0.0 2.9e-63 213.5 0.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001082226.1_37923001_1 - 5.4e-06 25.8 6.3 0.0023 17.3 1.4 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001082226.1_37923001_1 - 3.1e-05 23.3 1.9 3.1e-05 23.3 1.9 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001082226.1_37923001_1 - 0.00053 19.7 3.1 0.00067 19.3 1.9 1.6 2 0 0 2 2 2 1 Olfactory receptor DUF2238 PF09997.7 001082226.1_37923001_1 - 0.064 12.9 1.4 0.12 12.0 1.4 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2238) DUF621 PF04789.13 001082226.1_37923001_1 - 0.081 11.9 7.3 0.15 11.1 7.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF621) DUF4342 PF14242.4 001082226.1_37923001_1 - 1.3 8.9 5.8 1.5 8.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4342) Defensin_propep PF00879.16 001032922.1_29621001_1 - 2.4e-24 85.3 1.9 3.6e-24 84.7 1.9 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001032922.1_29621001_1 - 9.9e-11 41.9 11.9 1.5e-10 41.3 11.9 1.3 1 0 0 1 1 1 1 Mammalian defensin Kinesin PF00225.21 001133269.1_43527001_1 - 6.3e-108 360.5 0.0 1.2e-107 359.5 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 001133269.1_43527001_1 - 3.9e-46 156.6 0.0 1.3e-45 154.9 0.0 2.0 1 0 0 1 1 1 1 Microtubule binding Spc7 PF08317.9 001133269.1_43527001_1 - 1.3e-05 24.1 10.7 1.3e-05 24.1 10.7 4.1 1 1 2 4 4 4 2 Spc7 kinetochore protein DUF4407 PF14362.4 001133269.1_43527001_1 - 0.58 9.3 26.8 1 8.5 7.1 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) AAA_22 PF13401.4 001133269.1_43527001_1 - 1.5 9.0 0.0 1.5 9.0 0.0 3.2 3 1 0 3 3 3 0 AAA domain Dickkopf_N PF04706.10 001173088.1_09922001_2 - 0.046 14.1 0.4 0.046 14.1 0.4 1.9 2 0 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region 7tm_1 PF00001.19 001244357.1_49825001_2 - 3.2e-37 128.1 21.5 4.5e-37 127.6 21.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001244357.1_49825001_2 - 0.00017 21.3 14.4 0.0037 16.9 14.4 2.1 1 1 0 1 1 1 1 Olfactory receptor Interferon PF00143.17 001166320.1_49822001_1 - 3e-63 212.7 0.0 3.6e-63 212.4 0.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Interferon PF00143.17 001166311.1_49822001_1 - 8.7e-66 220.9 0.3 9.9e-66 220.7 0.3 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain 7tm_1 PF00001.19 001246670.1_49823001_2 - 9.8e-51 172.4 12.7 1.3e-50 172.0 12.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001246670.1_49823001_2 - 8e-14 51.5 4.5 1.1e-13 51.1 4.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001246670.1_49823001_2 - 5.3e-07 29.5 10.6 1.3e-06 28.2 10.6 1.7 1 1 0 1 1 1 1 Olfactory receptor Herpes_US9 PF06072.9 001246670.1_49823001_2 - 0.014 15.1 0.5 0.07 12.9 0.5 2.2 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 7TM_GPCR_Srx PF10328.7 001246670.1_49823001_2 - 0.13 11.4 5.6 0.087 12.0 3.6 1.8 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF2116 PF09889.7 001246670.1_49823001_2 - 4.7 7.1 6.1 3.4 7.6 0.1 2.9 3 0 0 3 3 3 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Interferon PF00143.17 001166312.1_49822001_1 - 7.5e-44 149.6 3.6 1e-43 149.2 3.6 1.2 1 0 0 1 1 1 1 Interferon alpha/beta domain zf-BED PF02892.13 001166312.1_49822001_1 - 0.58 10.1 2.9 0.57 10.1 1.1 2.0 2 0 0 2 2 2 0 BED zinc finger SH3_2 PF07653.15 001134678.1_43529001_1 - 6e-10 38.5 0.0 1.6e-09 37.1 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain NPIP PF06409.9 001134678.1_43529001_1 - 0.16 11.0 14.0 0.0068 15.5 6.9 2.1 2 0 0 2 2 2 0 Nuclear pore complex interacting protein (NPIP) Reo_sigmaC PF04582.10 001134678.1_43529001_1 - 0.45 9.7 11.9 1.9 7.7 2.2 2.4 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DUF3584 PF12128.6 001134678.1_43529001_1 - 3.9 4.7 56.0 11 3.2 56.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) ATG16 PF08614.9 001134678.1_43529001_1 - 4.6 7.2 80.7 0.01 15.9 23.5 5.2 2 1 3 5 5 5 0 Autophagy protein 16 (ATG16) ATAD4 PF15321.4 001267885.1_39522001_1 - 1.9e-23 83.5 0.3 2.7e-23 83.0 0.3 1.2 1 0 0 1 1 1 1 ATPase family AAA domain containing 4 FOXO_KIX_bdg PF16675.3 001267889.1_39525001_1 - 1.5e-34 117.9 9.6 1.5e-34 117.9 9.6 2.2 2 0 0 2 2 2 1 KIX-binding domain of forkhead box O, CR2 Forkhead PF00250.16 001267889.1_39525001_1 - 1.3e-24 86.2 0.0 2.5e-24 85.3 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain FOXO-TAD PF16676.3 001267889.1_39525001_1 - 4.7e-22 78.0 8.0 1e-21 76.9 8.0 1.6 1 0 0 1 1 1 1 Transactivation domain of FOXO protein family MACPF PF01823.17 001267892.1_49825001_2 - 4.4e-27 95.4 0.1 2.1e-26 93.2 0.0 1.9 2 0 0 2 2 2 1 MAC/Perforin domain Filament PF00038.19 001199066.1_39525001_3 - 3.5e-96 322.3 30.2 4.2e-96 322.1 30.2 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001199066.1_39525001_3 - 1.5e-13 51.1 1.5 1.5e-13 51.1 1.5 2.0 2 0 0 2 2 1 1 Keratin type II head TPR_MLP1_2 PF07926.10 001199066.1_39525001_3 - 7.2e-06 26.0 26.8 0.00021 21.3 1.3 3.6 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein BAT PF15915.3 001199066.1_39525001_3 - 0.00047 19.9 0.4 0.00097 18.9 0.4 1.5 1 0 0 1 1 1 1 GAF and HTH_10 associated domain DUF4924 PF16271.3 001199066.1_39525001_3 - 0.01 15.7 0.8 0.019 14.8 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4924) Spc7 PF08317.9 001199066.1_39525001_3 - 0.073 11.8 25.8 0.52 9.0 12.3 2.8 1 1 1 2 2 2 0 Spc7 kinetochore protein Alanine_zipper PF11839.6 001199066.1_39525001_3 - 0.092 12.9 7.4 0.25 11.5 7.3 1.8 2 0 0 2 2 1 0 Alanine-zipper, major outer membrane lipoprotein BRE1 PF08647.9 001199066.1_39525001_3 - 0.12 12.3 14.1 0.039 13.9 1.6 3.4 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase DUF1635 PF07795.9 001199066.1_39525001_3 - 0.16 11.8 4.2 0.38 10.6 4.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Reo_sigmaC PF04582.10 001199066.1_39525001_3 - 0.8 8.9 2.8 8 5.6 1.7 2.3 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Cep57_MT_bd PF06657.11 001199066.1_39525001_3 - 1.2 9.5 5.2 1 9.8 1.5 2.8 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Spc42p PF11544.6 001199066.1_39525001_3 - 1.2 9.0 5.1 0.57 10.1 0.4 2.4 2 0 0 2 2 2 0 Spindle pole body component Spc42p Tropomyosin_1 PF12718.5 001199066.1_39525001_3 - 2.9 7.9 26.8 0.027 14.5 9.8 3.5 3 1 1 4 4 4 0 Tropomyosin like SPATA1_C PF15743.3 001199066.1_39525001_3 - 3.5 7.5 14.8 0.48 10.4 0.4 2.7 2 1 1 3 3 3 0 Spermatogenesis-associated C-terminus FlaC_arch PF05377.9 001199066.1_39525001_3 - 5.7 7.3 7.2 15 6.0 0.9 3.8 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) RPEL PF02755.13 001133115.1_43524001_2 - 2.1e-21 74.8 22.0 1.2e-06 27.9 3.2 4.6 4 0 0 4 4 4 4 RPEL repeat Sod_Ni PF09055.9 001133115.1_43524001_2 - 0.043 14.2 1.3 0.083 13.3 1.3 1.4 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase DEAD PF00270.27 001246847.1_37626001_2 - 7.1e-48 162.6 0.0 1.5e-47 161.5 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001246847.1_37626001_2 - 1.6e-31 108.8 0.3 8.3e-31 106.5 0.2 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 001246847.1_37626001_2 - 0.0044 16.9 0.0 0.0081 16.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Keratin_matx PF04579.10 001009475.1_39523001_1 - 4.8e-43 145.3 34.6 7.4e-43 144.7 34.6 1.3 1 0 0 1 1 1 1 Keratin, high-sulphur matrix protein RR_TM4-6 PF06459.10 001047978.1_45723001_1 - 0.075 12.7 9.0 0.11 12.2 9.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pox_Ag35 PF03286.12 001047978.1_45723001_1 - 0.47 10.1 16.0 0.73 9.5 16.0 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FAM176 PF14851.4 001047978.1_45723001_1 - 0.6 9.7 11.5 1.1 8.8 11.5 1.4 1 0 0 1 1 1 0 FAM176 family RNA_pol_Rpc4 PF05132.12 001047978.1_45723001_1 - 0.6 10.4 6.8 1.4 9.2 6.8 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 CDC45 PF02724.12 001047978.1_45723001_1 - 0.66 8.1 6.1 0.85 7.7 6.1 1.1 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.4 001047978.1_45723001_1 - 1.1 9.6 12.3 2.2 8.7 12.3 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF913 PF06025.10 001047978.1_45723001_1 - 1.1 8.0 4.4 1.9 7.3 4.4 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Ribosomal_60s PF00428.17 001047978.1_45723001_1 - 1.2 9.6 11.1 2.1 8.8 11.1 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein FLO_LFY PF01698.14 001047978.1_45723001_1 - 1.2 8.1 7.6 1.7 7.6 7.6 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein Sporozoite_P67 PF05642.9 001047978.1_45723001_1 - 1.3 6.9 9.7 1.7 6.5 9.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Afi1 PF07792.10 001047978.1_45723001_1 - 2.7 8.4 11.1 4.7 7.6 11.1 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4746 PF15928.3 001047978.1_45723001_1 - 7.1 5.8 12.8 10 5.3 12.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RNA_polI_A34 PF08208.9 001047978.1_45723001_1 - 7.3 6.5 20.1 11 5.9 20.1 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Coilin_N PF15862.3 001047978.1_45723001_1 - 9 6.0 15.1 16 5.1 15.1 1.3 1 0 0 1 1 1 0 Coilin N-terminus Ion_trans PF00520.29 001082658.1_37925001_2 - 2.4e-43 148.0 10.7 2.9e-43 147.7 10.7 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001082658.1_37925001_2 - 2.2e-26 91.9 0.0 3.6e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 001082658.1_37925001_2 - 7.8e-10 38.5 5.3 7.8e-10 38.5 5.3 2.4 2 0 0 2 2 2 1 Ion channel Potassium_chann PF11404.6 001082658.1_37925001_2 - 2.1e-07 30.5 0.3 4.5e-07 29.4 0.3 1.6 1 0 0 1 1 1 1 Potassium voltage-gated channel BTB_3 PF16017.3 001082658.1_37925001_2 - 0.029 14.4 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain DUF3558 PF12079.6 001082658.1_37925001_2 - 1.2 9.0 4.4 3 7.7 4.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) MgtE PF01769.14 001082658.1_37925001_2 - 4.9 7.4 6.6 0.63 10.3 0.5 2.3 2 1 1 3 3 3 0 Divalent cation transporter PKD_channel PF08016.10 001082658.1_37925001_2 - 6.5 5.2 7.3 5.5 5.4 3.4 2.0 1 1 1 2 2 2 0 Polycystin cation channel Vert_IL3-reg_TF PF06529.9 001142892.1_39523001_1 - 4e-194 644.0 15.9 5.3e-194 643.7 15.9 1.1 1 0 0 1 1 1 1 Vertebrate interleukin-3 regulated transcription factor bZIP_2 PF07716.13 001142892.1_39523001_1 - 1.1e-14 54.1 9.6 1.1e-14 54.1 9.6 2.4 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.19 001142892.1_39523001_1 - 0.00024 21.0 7.1 0.00024 21.0 7.1 3.4 4 0 0 4 4 4 1 bZIP transcription factor IncA PF04156.12 001142892.1_39523001_1 - 0.48 10.1 5.2 1.6 8.4 5.3 2.1 1 1 0 1 1 1 0 IncA protein BRICHOS PF04089.12 001131031.1_39522001_1 - 1.7e-21 76.0 0.0 2.9e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 BRICHOS domain p450 PF00067.20 001048012.1_22423001_1 - 1.4e-143 478.9 0.0 1.6e-143 478.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PQQ PF01011.19 001266648.1_29627001_1 - 0.047 13.5 0.2 0.1 12.5 0.2 1.5 1 0 0 1 1 1 0 PQQ enzyme repeat bZIP_1 PF00170.19 001266648.1_29627001_2 - 1.4e-06 28.1 5.9 2.6e-06 27.3 5.9 1.4 1 0 0 1 1 1 1 bZIP transcription factor ZapB PF06005.10 001266648.1_29627001_2 - 0.005 17.1 0.8 0.0094 16.2 0.8 1.3 1 0 0 1 1 1 1 Cell division protein ZapB Macoilin PF09726.7 001266648.1_29627001_2 - 0.0069 14.9 0.6 0.0095 14.4 0.6 1.1 1 0 0 1 1 1 1 Transmembrane protein ATG16 PF08614.9 001266648.1_29627001_2 - 0.033 14.2 1.3 0.055 13.5 1.3 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) bZIP_2 PF07716.13 001266648.1_29627001_2 - 0.034 14.1 8.9 0.025 14.5 6.4 2.1 1 1 1 2 2 2 0 Basic region leucine zipper TSC22 PF01166.16 001266648.1_29627001_2 - 0.047 13.9 0.6 0.73 10.1 0.5 2.2 1 1 1 2 2 2 0 TSC-22/dip/bun family GIT_CC PF16559.3 001266648.1_29627001_2 - 0.062 13.2 0.4 0.12 12.3 0.4 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DivIC PF04977.13 001266648.1_29627001_2 - 0.084 12.5 0.9 0.15 11.7 0.9 1.4 1 0 0 1 1 1 0 Septum formation initiator Vps5 PF09325.8 001266648.1_29627001_2 - 0.093 12.1 0.2 0.14 11.6 0.2 1.1 1 0 0 1 1 1 0 Vps5 C terminal like LBP_BPI_CETP PF01273.23 001243083.1_22422001_1 - 1.7e-13 50.4 0.0 3e-13 49.6 0.0 1.5 1 1 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain APS_kinase PF01583.18 001173104.1_09927001_2 - 2.9e-71 238.3 0.0 4.4e-71 237.8 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase ATP-sulfurylase PF01747.15 001173104.1_09927001_2 - 1.2e-67 227.3 0.0 1.8e-67 226.8 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.4 001173104.1_09927001_2 - 1.9e-48 164.0 0.0 3e-48 163.3 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.4 001173104.1_09927001_2 - 0.00016 21.7 0.0 0.00034 20.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 001173104.1_09927001_2 - 0.0022 18.4 0.0 0.0055 17.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Defensin_beta_2 PF13841.4 001146712.1_40421001_3 - 7e-08 32.7 12.3 9e-08 32.3 12.3 1.2 1 0 0 1 1 1 1 Beta defensin Defensin_beta PF00711.17 001146712.1_40421001_3 - 0.64 10.0 9.5 0.9 9.5 9.5 1.2 1 0 0 1 1 1 0 Beta defensin TGF_beta PF00019.18 001165898.1_22423001_1 - 7.1e-26 91.0 0.1 1.4e-25 90.1 0.1 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain p450 PF00067.20 001133753.1_43524001_2 - 8.6e-134 446.6 0.0 1.1e-133 446.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PAS_3 PF08447.10 001133753.1_43524001_2 - 0.15 12.2 0.2 0.38 10.9 0.2 1.6 1 0 0 1 1 1 0 PAS fold ADAM_CR PF08516.10 020305.1_45725001_2 - 1.5e-29 102.6 4.6 1.5e-29 102.6 4.6 3.7 3 2 0 3 3 3 1 ADAM cysteine-rich Reprolysin PF01421.17 020305.1_45725001_2 - 1e-19 71.1 0.4 1e-19 71.1 0.4 2.7 3 0 0 3 3 3 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 020305.1_45725001_2 - 8.8e-19 68.0 0.0 1.9e-18 66.9 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.21 020305.1_45725001_2 - 4.9e-17 62.4 26.7 4.9e-17 62.4 26.7 3.8 3 0 0 3 3 3 1 Disintegrin 5TM-5TMR_LYT PF07694.10 001266918.1_29625001_1 - 4.5 6.6 24.7 0.77 9.1 8.7 3.5 2 1 1 3 3 3 0 5TMR of 5TMR-LYT Ank_2 PF12796.5 001131297.1_43524001_2 - 8.7e-26 90.2 2.2 2e-14 53.8 0.3 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001131297.1_43524001_2 - 5.2e-17 61.8 1.1 4.5e-10 39.7 0.2 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 001131297.1_43524001_2 - 1.7e-15 56.8 0.8 3.3e-10 39.9 0.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 001131297.1_43524001_2 - 5.8e-12 45.4 1.3 2.1e-08 34.1 0.1 3.5 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.4 001131297.1_43524001_2 - 3.8e-09 35.9 0.2 0.00021 21.3 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat SAM_1 PF00536.28 001131297.1_43524001_2 - 1.3e-08 35.1 0.1 3e-08 33.8 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 001131297.1_43524001_2 - 0.00028 20.8 0.3 0.00053 19.9 0.3 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ras PF00071.20 001161870.1_39522001_1 - 3.2e-57 192.5 0.0 3.8e-57 192.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001161870.1_39522001_1 - 7.3e-30 103.5 0.0 1.1e-29 102.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001161870.1_39522001_1 - 1.6e-11 43.8 0.0 2.1e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001161870.1_39522001_1 - 3.3e-06 27.0 0.0 1.5e-05 25.0 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.14 001161870.1_39522001_1 - 1.8e-05 24.6 0.0 0.011 15.6 0.1 2.4 2 1 0 2 2 2 2 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 001161870.1_39522001_1 - 0.00022 20.5 0.0 0.00027 20.2 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001161870.1_39522001_1 - 0.0078 15.6 0.0 0.015 14.7 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.15 001161870.1_39522001_1 - 0.014 15.0 0.1 0.095 12.3 0.0 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.4 001161870.1_39522001_1 - 0.022 15.0 0.0 0.048 13.9 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.18 001161870.1_39522001_1 - 0.051 12.6 0.7 3.1 6.7 0.0 2.5 1 1 1 2 2 2 0 G-protein alpha subunit PduV-EutP PF10662.7 001161870.1_39522001_1 - 0.067 12.8 0.0 1.5 8.4 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.8 001161870.1_39522001_1 - 0.099 11.9 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Ig_2 PF13895.4 001040670.1_29626001_2 - 1.3e-27 95.8 0.5 1.7e-12 47.4 0.1 4.4 4 0 0 4 4 4 4 Immunoglobulin domain Ig_3 PF13927.4 001040670.1_29626001_2 - 4e-19 68.9 0.5 0.00032 21.1 0.0 4.9 4 1 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 001040670.1_29626001_2 - 4.3e-13 49.1 0.9 0.00049 20.1 0.0 5.1 4 2 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 001040670.1_29626001_2 - 0.031 14.3 6.7 18 5.4 0.0 5.8 5 2 1 6 6 6 0 Immunoglobulin V-set domain Peptidase_C1 PF00112.21 001002813.2_45723001_2 - 5.9e-76 255.3 1.1 8.2e-76 254.8 1.1 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 001002813.2_45723001_2 - 1.2e-13 51.1 2.4 2.2e-13 50.3 2.4 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 001002813.2_45723001_2 - 0.0014 17.3 0.4 0.0028 16.4 0.4 1.4 1 0 0 1 1 1 1 Peptidase C1-like family Pkinase PF00069.23 001132142.1_43529001_2 - 9.5e-64 215.2 0.1 1.5e-63 214.6 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001132142.1_43529001_2 - 4.4e-37 127.6 0.2 6.3e-37 127.1 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001132142.1_43529001_2 - 1.6e-10 40.7 0.0 2.2e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 001132142.1_43529001_2 - 0.036 13.9 0.1 0.063 13.1 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family SCP2 PF02036.15 001132644.1_43526001_3 - 6e-30 103.6 0.4 1e-29 102.8 0.4 1.3 1 0 0 1 1 1 1 SCP-2 sterol transfer family Thiolase_N PF00108.21 001132644.1_43526001_3 - 3.8e-22 78.8 0.0 3.8e-21 75.5 0.0 2.4 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 001132644.1_43526001_3 - 3.2e-13 49.3 0.2 3.4e-12 46.0 0.1 2.6 2 1 0 2 2 2 1 Thiolase, C-terminal domain Alkyl_sulf_C PF14864.4 001132644.1_43526001_3 - 6.5e-06 26.3 0.0 1.1e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal ACP_syn_III PF08545.8 001132644.1_43526001_3 - 0.00026 20.6 0.4 0.016 15.0 0.1 2.5 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ketoacyl-synt_C PF02801.20 001132644.1_43526001_3 - 0.0031 17.4 0.0 0.12 12.2 0.0 2.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.24 001132644.1_43526001_3 - 0.0078 15.7 0.6 0.027 13.9 0.6 1.7 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SpoVAD PF07451.9 001132644.1_43526001_3 - 0.079 11.5 0.2 0.34 9.4 0.1 1.8 2 0 0 2 2 2 0 Stage V sporulation protein AD (SpoVAD) Reprolysin PF01421.17 001082701.1_37927001_3 - 2.4e-68 229.8 0.3 4.4e-68 229.0 0.3 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 001082701.1_37927001_3 - 1.6e-30 105.7 2.1 1.6e-30 105.7 2.1 3.2 2 2 2 4 4 1 1 ADAM cysteine-rich Disintegrin PF00200.21 001082701.1_37927001_3 - 8.1e-17 61.7 24.2 8.1e-17 61.7 24.2 3.7 4 0 0 4 4 2 1 Disintegrin Pep_M12B_propep PF01562.17 001082701.1_37927001_3 - 9.2e-16 58.2 0.1 1.8e-15 57.3 0.1 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 001082701.1_37927001_3 - 1.9e-14 54.2 4.0 3.9e-14 53.1 4.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 001082701.1_37927001_3 - 2.4e-12 47.3 0.6 4.5e-12 46.4 0.6 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001082701.1_37927001_3 - 2.3e-07 30.5 0.4 3.9e-07 29.8 0.4 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.11 001082701.1_37927001_3 - 0.00075 19.7 10.3 0.00075 19.7 10.3 4.8 5 0 0 5 5 4 1 EGF-like domain EB PF01683.16 001082701.1_37927001_3 - 0.0045 17.1 14.7 0.0045 17.1 14.7 5.1 3 1 0 3 3 2 1 EB module Reprolysin_2 PF13574.4 001082701.1_37927001_3 - 0.013 15.3 0.8 0.024 14.4 0.8 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.22 001082701.1_37927001_3 - 0.025 14.3 0.2 0.045 13.5 0.2 1.3 1 0 0 1 1 1 0 Matrixin DUF1510 PF07423.9 001082701.1_37927001_3 - 0.029 13.7 0.0 0.046 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Phage_Gp23 PF10669.7 001082701.1_37927001_3 - 0.082 13.1 0.3 0.15 12.2 0.3 1.3 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) FGF PF00167.16 001009230.1_39526001_3 - 1.4e-46 157.5 2.2 2.4e-46 156.8 2.2 1.4 1 0 0 1 1 1 1 Fibroblast growth factor IL28A PF15177.4 001040680.1_22422001_1 - 5.7e-71 237.3 0.1 6.6e-71 237.1 0.1 1.0 1 0 0 1 1 1 1 Interleukin-28A Interferon PF00143.17 001164854.1_49822001_1 - 2.3e-47 161.0 2.1 3.1e-47 160.6 2.1 1.2 1 0 0 1 1 1 1 Interferon alpha/beta domain SAS4 PF15460.4 001164854.1_49822001_1 - 0.17 11.9 1.3 9.5 6.3 0.3 2.3 2 0 0 2 2 2 0 Something about silencing, SAS, complex subunit 4 IL7 PF01415.14 001166043.1_49822001_2 - 5.4e-45 152.6 5.9 6.2e-45 152.4 5.9 1.0 1 0 0 1 1 1 1 Interleukin 7/9 family I-set PF07679.14 001244697.1_49823001_2 - 2e-44 149.4 5.2 2.7e-17 62.5 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 001244697.1_49823001_2 - 7.9e-44 148.0 7.2 1.2e-18 67.4 0.9 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 001244697.1_49823001_2 - 6.1e-32 109.5 5.9 1.5e-13 50.6 0.2 4.5 4 1 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.4 001244697.1_49823001_2 - 1.7e-31 108.2 4.4 2.8e-13 49.9 0.2 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001244697.1_49823001_2 - 3.8e-18 65.5 6.0 8.4e-07 29.0 0.1 5.6 3 3 1 4 4 4 3 Immunoglobulin V-set domain Ig_5 PF16681.3 001244697.1_49823001_2 - 2.4e-10 40.6 1.2 0.036 14.3 0.0 3.7 3 2 0 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 001244697.1_49823001_2 - 3e-08 33.5 1.2 0.0073 16.2 0.1 3.9 4 0 0 4 4 4 3 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 001244697.1_49823001_2 - 9.8e-06 25.4 2.9 0.091 12.7 0.0 3.5 3 1 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.3 001244697.1_49823001_2 - 1.7e-05 25.0 5.5 0.082 13.1 0.0 4.2 3 2 1 4 4 4 1 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.13 001244697.1_49823001_2 - 0.00017 21.9 3.1 1.3 9.4 0.1 3.8 3 1 0 3 3 3 2 Immunoglobulin C1-set domain V-set_CD47 PF08204.9 001244697.1_49823001_2 - 0.0002 21.2 3.1 0.18 11.6 0.3 3.0 2 1 1 3 3 3 2 CD47 immunoglobulin-like domain Adeno_E3_CR1 PF02440.13 001244697.1_49823001_2 - 0.00059 19.4 5.5 1.3 8.7 0.1 4.3 3 2 0 3 3 3 2 Adenovirus E3 region protein CR1 C2-set PF05790.13 001244697.1_49823001_2 - 0.044 13.8 1.0 27 4.9 0.0 4.3 5 0 0 5 5 5 0 Immunoglobulin C2-set domain p450 PF00067.20 001009743.1_39524001_1 - 6.1e-127 424.0 0.1 7.1e-127 423.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Interferon PF00143.17 001164847.1_49822001_1 - 1.5e-43 148.7 3.1 2e-43 148.2 3.1 1.2 1 0 0 1 1 1 1 Interferon alpha/beta domain Interferon PF00143.17 001164851.1_49822001_1 - 2.4e-47 161.0 2.9 3.1e-47 160.6 2.9 1.2 1 0 0 1 1 1 1 Interferon alpha/beta domain SAS4 PF15460.4 001164851.1_49822001_1 - 0.25 11.4 2.1 9.5 6.3 0.3 2.4 2 0 0 2 2 2 0 Something about silencing, SAS, complex subunit 4 V-set PF07686.15 001131626.1_43529001_2 - 1.7e-58 195.3 6.3 1.6e-14 53.8 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin V-set domain Ig_3 PF13927.4 001131626.1_43529001_2 - 1.1e-16 61.0 10.4 0.0011 19.4 1.1 5.5 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 001131626.1_43529001_2 - 5.7e-16 58.3 4.5 0.04 14.0 0.0 6.0 5 1 0 5 5 5 5 Immunoglobulin domain I-set PF07679.14 001131626.1_43529001_2 - 5.9e-12 45.4 0.1 0.028 14.4 0.0 5.3 5 1 0 5 5 5 3 Immunoglobulin I-set domain Ig_2 PF13895.4 001131626.1_43529001_2 - 4.6e-06 26.7 13.1 0.022 15.0 0.0 5.4 5 1 0 5 5 5 3 Immunoglobulin domain Motilin_ghrelin PF04644.10 001252423.1_40421001_1 - 9.2e-05 22.1 0.1 0.00015 21.4 0.1 1.3 1 0 0 1 1 1 1 Motilin/ghrelin Ig_3 PF13927.4 001132048.1_43525001_2 - 6.6e-15 55.4 2.0 2.4e-07 31.1 0.2 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001132048.1_43525001_2 - 6.3e-11 42.3 1.2 3.7e-05 23.9 0.2 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 001132048.1_43525001_2 - 2e-08 34.2 1.1 0.024 14.7 0.1 3.6 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 001132048.1_43525001_2 - 1.2e-07 31.5 0.1 0.44 10.5 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain Sushi PF00084.18 001009749.1_39524001_3 - 1.2e-31 109.0 43.0 4.6e-10 39.8 2.5 5.5 4 1 1 5 5 5 4 Sushi repeat (SCR repeat) Lectin_C PF00059.19 001009749.1_39524001_3 - 5.3e-25 88.1 5.1 5.3e-25 88.1 5.1 2.5 2 1 0 2 2 2 1 Lectin C-type domain EGF PF00008.25 001009749.1_39524001_3 - 4.8e-06 26.6 7.7 4.8e-06 26.6 7.7 4.8 5 0 0 5 5 5 1 EGF-like domain hEGF PF12661.5 001009749.1_39524001_3 - 0.002 18.6 4.1 0.002 18.6 4.1 4.5 6 0 0 6 6 6 1 Human growth factor-like EGF EGF_3 PF12947.5 001009749.1_39524001_3 - 0.0061 16.6 5.7 0.0061 16.6 5.7 4.3 3 1 1 4 4 4 1 EGF domain EGF_2 PF07974.11 001009749.1_39524001_3 - 0.019 15.2 11.8 0.048 13.9 9.0 3.4 2 0 0 2 2 2 0 EGF-like domain cEGF PF12662.5 001009749.1_39524001_3 - 0.087 12.6 27.7 0.11 12.3 2.5 5.9 5 0 0 5 5 5 0 Complement Clr-like EGF-like CXCXC PF03128.12 001009749.1_39524001_3 - 6.2 7.4 8.1 7.2 7.1 0.9 3.8 2 0 0 2 2 2 0 CXCXC repeat BTG PF07742.10 001246209.1_39528001_1 - 1.6e-35 121.3 0.0 3.7e-35 120.1 0.0 1.6 2 0 0 2 2 2 1 BTG family PAM2 PF07145.13 001246209.1_39528001_1 - 1.5e-11 43.0 0.2 7.1e-05 22.1 0.1 2.8 2 0 0 2 2 2 2 Ataxin-2 C-terminal region Ras PF00071.20 001127286.1_39522001_1 - 1.6e-44 151.3 0.0 1.8e-44 151.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001127286.1_39522001_1 - 9.3e-23 80.6 0.0 1.3e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001127286.1_39522001_1 - 1.6e-07 30.8 0.0 1.9e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001127286.1_39522001_1 - 0.0037 17.2 0.0 0.0059 16.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.8 001127286.1_39522001_1 - 0.039 13.3 0.0 0.063 12.6 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.9 001127286.1_39522001_1 - 0.11 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.7 001127286.1_39522001_1 - 0.12 12.0 0.0 0.73 9.4 0.0 2.3 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.4 001127286.1_39522001_1 - 0.13 12.5 0.1 0.26 11.5 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain Interferon PF00143.17 001164852.1_49822001_1 - 3.2e-64 215.8 4.4 3.6e-64 215.6 4.4 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain 7tm_1 PF00001.19 001172749.1_09923001_1 - 2.4e-37 128.5 21.7 2.4e-37 128.5 21.7 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001172749.1_09923001_1 - 0.0063 15.7 35.3 0.1 11.8 35.1 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.4 001172749.1_09923001_1 - 0.026 14.1 24.8 0.041 13.5 24.8 1.3 1 0 0 1 1 1 0 Olfactory receptor FA_desaturase PF00487.22 001172749.1_09923001_1 - 2.5 7.7 9.5 1.2 8.7 0.6 2.7 1 1 2 3 3 3 0 Fatty acid desaturase PRY PF13765.4 001082731.1_37924001_2 - 2.3e-17 62.2 0.3 1.2e-16 59.9 0.2 2.3 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.26 001082731.1_37924001_2 - 7.3e-16 58.3 0.0 1.4e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 SPRY domain bZIP_1 PF00170.19 001082731.1_37924001_2 - 0.0074 16.2 0.9 0.0074 16.2 0.9 3.6 3 1 0 3 3 2 1 bZIP transcription factor BLOC1_2 PF10046.7 001082731.1_37924001_2 - 0.018 15.2 2.4 0.018 15.2 2.4 4.0 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Sec34 PF04136.13 001082731.1_37924001_2 - 1.1 9.1 9.2 0.43 10.3 4.3 2.3 1 1 1 2 2 2 0 Sec34-like family HALZ PF02183.16 001082731.1_37924001_2 - 2.8 8.1 25.1 0.35 11.0 2.6 4.3 4 1 0 4 4 4 0 Homeobox associated leucine zipper Spc7 PF08317.9 001082731.1_37924001_2 - 3.2 6.4 27.1 0.32 9.7 17.6 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein MerR-DNA-bind PF09278.9 001082731.1_37924001_2 - 3.3 8.2 12.7 4.1 7.9 3.8 3.3 3 0 0 3 3 3 0 MerR, DNA binding GIT_CC PF16559.3 001082731.1_37924001_2 - 3.4 7.7 14.0 3.6 7.6 3.0 3.4 1 1 2 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor FUSC PF04632.10 001082731.1_37924001_2 - 3.7 5.9 5.9 3.1 6.1 4.9 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family T3SSipB PF16535.3 001082731.1_37924001_2 - 4.4 7.6 11.0 14 6.0 6.6 2.8 1 1 1 2 2 2 0 Type III cell invasion protein SipB Lectin_N PF03954.12 001082731.1_37924001_3 - 0.023 14.3 2.2 24 4.5 0.2 3.3 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain DUF2746 PF10874.6 001082731.1_37924001_3 - 4.2 7.7 11.7 35 4.7 0.2 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF2746) DUF2981 PF11200.6 001172759.1_09924001_1 - 0.24 10.4 2.1 0.38 9.8 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Ig_3 PF13927.4 001172759.1_09924001_3 - 1e-15 58.0 0.5 4e-12 46.5 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001172759.1_09924001_3 - 3e-14 52.7 0.2 1e-11 44.6 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin I-set domain V-set PF07686.15 001172759.1_09924001_3 - 9.7e-14 51.3 1.4 3.5e-06 27.0 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.23 001172759.1_09924001_3 - 8.7e-13 48.1 0.8 8.2e-12 45.0 0.3 2.3 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001172759.1_09924001_3 - 2.3e-10 40.5 0.4 8e-09 35.6 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Receptor_2B4 PF11465.6 001172759.1_09924001_3 - 0.00086 19.4 0.1 0.011 15.8 0.0 2.1 2 0 0 2 2 2 1 Natural killer cell receptor 2B4 Ig_4 PF16680.3 001172759.1_09924001_3 - 0.011 15.9 0.1 0.03 14.6 0.1 1.7 1 0 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.3 001172759.1_09924001_3 - 0.027 14.8 0.1 0.058 13.7 0.1 1.5 1 0 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 001172759.1_09924001_3 - 0.032 14.1 0.0 0.067 13.1 0.0 1.5 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.9 001172759.1_09924001_3 - 0.043 13.7 0.8 0.14 12.0 0.8 1.8 1 1 0 1 1 1 0 CD47 immunoglobulin-like domain Shisa PF13908.4 001172759.1_09924001_3 - 0.1 12.7 0.7 0.23 11.5 0.7 1.6 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator OAD_gamma PF04277.11 001172759.1_09924001_3 - 0.66 10.5 7.3 6.6 7.3 7.3 2.2 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain FAP PF07174.9 001172759.1_09924001_3 - 1.9 7.7 17.2 3.1 7.1 17.2 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Trypan_PARP PF05887.9 001172759.1_09924001_3 - 3.2 7.6 23.9 5.4 6.9 23.9 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) ADAM_CR PF08516.10 001165916.1_37925001_3 - 5e-27 94.5 10.3 5e-27 94.5 10.3 4.1 3 1 0 3 3 3 1 ADAM cysteine-rich Disintegrin PF00200.21 001165916.1_37925001_3 - 3.9e-16 59.5 27.0 3.9e-16 59.5 27.0 4.4 4 1 0 4 4 4 1 Disintegrin Pep_M12B_propep PF01562.17 001165916.1_37925001_3 - 3.4e-12 46.6 0.0 7.7e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide NAP PF00956.16 001012075.1_45725001_1 - 2.2e-23 82.7 0.4 1.5e-20 73.4 0.0 2.5 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) 7tm_1 PF00001.19 001098401.1_29623001_1 - 2e-51 174.7 17.7 3.1e-51 174.0 17.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001098401.1_29623001_1 - 3.5e-06 26.8 11.2 2.7e-05 23.9 11.2 2.0 1 1 0 1 1 1 1 Olfactory receptor Sprouty PF05210.11 001098401.1_29623001_1 - 0.92 9.9 5.0 19 5.7 5.0 2.5 1 1 0 1 1 1 0 Sprouty protein (Spry) CybS PF05328.10 001093781.1_39521001_1 - 1.3e-24 86.3 0.2 1.5e-24 86.1 0.2 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit SH3_1 PF00018.26 001082102.1_37923001_3 - 7.4e-27 92.6 0.6 2.8e-13 49.1 0.0 3.1 4 0 0 4 4 4 2 SH3 domain NECFESHC PF16621.3 001082102.1_37923001_3 - 1.2e-23 82.7 12.2 1.2e-23 82.7 12.2 2.1 2 0 0 2 2 2 1 SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1 SH3_9 PF14604.4 001082102.1_37923001_3 - 1.1e-22 79.5 0.0 5.5e-10 38.8 0.0 3.0 3 0 0 3 3 3 2 Variant SH3 domain p47_phox_C PF08944.9 001082102.1_37923001_3 - 1.2e-19 69.2 3.5 3.2e-19 67.9 3.5 1.8 1 0 0 1 1 1 1 NADPH oxidase subunit p47Phox, C terminal domain SH3_2 PF07653.15 001082102.1_37923001_3 - 4.1e-18 64.7 0.2 1.9e-09 36.9 0.0 2.6 3 0 0 3 3 3 2 Variant SH3 domain PX PF00787.22 001082102.1_37923001_3 - 4.4e-17 62.0 0.1 9e-17 61.0 0.1 1.5 1 0 0 1 1 1 1 PX domain hSH3 PF14603.4 001082102.1_37923001_3 - 0.0066 16.8 0.0 0.52 10.7 0.0 2.3 2 0 0 2 2 2 1 Helically-extended SH3 domain SH3_3 PF08239.9 001082102.1_37923001_3 - 0.15 12.2 0.1 1.7 8.8 0.0 2.2 2 0 0 2 2 2 0 Bacterial SH3 domain Sulfotransfer_1 PF00685.25 001160287.1_37922001_1 - 4.4e-82 275.4 0.0 5.1e-82 275.2 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001160287.1_37922001_1 - 1.9e-08 34.8 0.0 2.2e-05 24.8 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family 7tm_1 PF00001.19 001160279.1_37923001_2 - 1.2e-52 178.7 12.4 1.5e-52 178.4 12.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001160279.1_37923001_2 - 2.7e-14 53.0 12.9 3.6e-14 52.6 12.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001160279.1_37923001_2 - 0.00032 20.0 8.7 0.00032 20.0 8.7 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001160279.1_37923001_2 - 0.0011 18.6 13.9 0.0018 17.9 13.9 1.4 1 1 0 1 1 1 1 Olfactory receptor Interferon PF00143.17 001164850.1_49822001_1 - 2.7e-59 199.8 4.5 3.1e-59 199.6 4.5 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain DUF1670 PF07900.9 001164850.1_49822001_1 - 0.065 12.4 0.0 0.085 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1670) DIRP PF06584.11 001164850.1_49822001_1 - 0.23 11.5 2.2 6 6.9 0.5 2.4 2 1 0 2 2 2 0 DIRP V1R PF03402.12 001167415.1_09922001_1 - 1.1e-34 120.1 14.2 1.4e-34 119.8 14.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167415.1_09922001_1 - 4e-10 39.2 16.0 4.8e-10 38.9 16.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167415.1_09922001_1 - 7e-05 22.1 13.2 0.00011 21.5 13.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167439.1_09922001_1 - 2.1e-32 112.7 14.3 2.6e-32 112.3 14.3 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R DUF2515 PF10720.7 001167439.1_09922001_1 - 0.0031 16.6 0.0 0.0056 15.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2515) 7tm_1 PF00001.19 001167439.1_09922001_1 - 0.015 14.4 14.5 0.034 13.3 14.5 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Fanconi_A PF03511.12 001167439.1_09922001_1 - 0.26 11.1 3.5 0.93 9.3 3.5 2.0 1 1 0 1 1 1 0 Fanconi anaemia group A protein V1R PF03402.12 001167440.1_09922001_1 - 1.2e-33 116.8 13.7 1.5e-33 116.5 13.7 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R DUF2515 PF10720.7 001167440.1_09922001_1 - 0.0056 15.8 0.0 0.01 14.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2515) 7tm_1 PF00001.19 001167440.1_09922001_1 - 0.011 14.9 12.7 0.024 13.8 12.7 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Fanconi_A PF03511.12 001167440.1_09922001_1 - 5.3 6.9 8.0 0.35 10.7 2.2 2.1 2 1 0 2 2 2 0 Fanconi anaemia group A protein V1R PF03402.12 001167441.1_09922001_1 - 1.8e-34 119.5 12.2 2.1e-34 119.2 12.2 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167441.1_09922001_1 - 4.5e-08 32.4 18.6 8.3e-08 31.5 18.6 1.4 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167442.1_09922001_1 - 7.1e-34 117.5 12.6 8.8e-34 117.2 12.6 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R DUF2515 PF10720.7 001167442.1_09922001_1 - 0.0056 15.8 0.0 0.01 14.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2515) 7tm_1 PF00001.19 001167442.1_09922001_1 - 0.0058 15.8 11.8 0.012 14.7 11.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167443.1_09922001_1 - 4.8e-32 111.5 15.8 6.2e-32 111.1 15.8 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167443.1_09922001_1 - 5.2e-06 25.7 19.3 6.7e-06 25.3 19.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167443.1_09922001_1 - 0.16 11.0 19.1 0.48 9.5 19.1 1.8 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167444.1_09923001_1 - 1.8e-27 96.5 14.1 3e-27 95.8 14.1 1.3 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R GP4 PF03010.12 001167444.1_09923001_1 - 0.0018 18.1 0.3 0.011 15.5 0.0 2.1 2 0 0 2 2 2 1 GP4 DUF1218 PF06749.10 001167444.1_09923001_1 - 0.17 12.3 1.9 0.45 10.9 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) MatE PF01554.16 001167444.1_09923001_1 - 7.4 6.1 9.9 0.39 10.2 0.7 2.6 3 0 0 3 3 3 0 MatE V1R PF03402.12 001167445.1_09922001_1 - 8.3e-30 104.2 18.2 1.1e-29 103.8 18.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R V1R PF03402.12 001167446.1_09922001_1 - 1.4e-89 300.1 20.1 1.4e-89 300.1 20.1 1.3 2 0 0 2 2 2 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167446.1_09922001_1 - 9.8e-09 34.6 24.8 1.3e-08 34.2 24.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167446.1_09922001_1 - 0.14 11.2 17.1 0.2 10.7 17.1 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF4956 PF16316.3 001167446.1_09922001_1 - 0.34 10.4 0.1 0.34 10.4 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4956) V1R PF03402.12 001167447.1_09922001_1 - 4.9e-83 278.7 17.0 6.1e-83 278.3 17.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167447.1_09922001_1 - 9.4e-05 21.5 22.2 0.00013 21.0 22.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167447.1_09922001_1 - 0.012 14.7 13.1 0.02 14.0 13.1 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167448.1_09922001_1 - 6.6e-88 294.6 13.4 8.3e-88 294.3 13.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167448.1_09922001_1 - 0.00017 20.7 20.1 0.00034 19.7 20.1 1.4 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167448.1_09922001_1 - 0.0034 16.5 12.0 0.0057 15.8 12.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GPR_Gpa2_C PF11970.6 001167448.1_09922001_1 - 3.3 7.7 6.3 0.96 9.4 1.1 2.8 3 1 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term V1R PF03402.12 001167449.1_09922001_1 - 3.3e-85 285.8 15.7 4.1e-85 285.5 15.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167449.1_09922001_1 - 5.8e-06 25.5 19.9 8.5e-06 24.9 19.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167449.1_09922001_1 - 0.034 13.2 12.2 0.066 12.3 12.2 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167450.1_09922001_1 - 7.8e-90 300.9 12.9 1e-89 300.6 12.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167450.1_09922001_1 - 1.1e-05 24.6 19.1 1.9e-05 23.8 19.1 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167450.1_09922001_1 - 0.041 13.0 12.8 0.076 12.1 12.8 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) GPR_Gpa2_C PF11970.6 001167450.1_09922001_1 - 3 7.8 6.9 0.63 10.0 1.0 2.9 3 1 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term V1R PF03402.12 001167451.1_09922001_1 - 5.6e-88 294.9 18.7 7.2e-88 294.5 18.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167451.1_09922001_1 - 5.3e-10 38.8 23.1 7.1e-10 38.3 23.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167451.1_09922001_1 - 0.023 13.8 15.7 0.034 13.3 15.7 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167452.1_09922001_1 - 1.5e-89 300.0 14.0 2e-89 299.6 14.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167452.1_09922001_1 - 1.6e-06 27.4 21.6 2.2e-06 26.9 21.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) GPR_Gpa2_C PF11970.6 001167452.1_09922001_1 - 0.63 10.0 3.9 1.4 9.0 1.3 2.9 2 1 1 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term V1R PF03402.12 001167453.1_09922001_1 - 1.6e-85 286.8 16.5 1.9e-85 286.5 16.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167453.1_09922001_1 - 0.2 10.7 13.7 0.4 9.8 13.7 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167454.1_09922001_1 - 1.7e-26 93.3 19.2 2.3e-26 92.9 19.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167454.1_09922001_1 - 3.7e-06 26.2 16.4 5.5e-06 25.7 16.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167454.1_09922001_1 - 8.9e-06 24.9 23.9 1.1e-05 24.6 23.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167455.1_09922001_1 - 1.5e-30 106.6 15.8 1.9e-30 106.2 15.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167455.1_09922001_1 - 9.5e-05 21.5 21.1 0.00013 21.0 21.1 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167456.1_09922001_1 - 4.4e-28 98.5 12.5 5.6e-28 98.2 12.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167456.1_09922001_1 - 5e-05 22.4 17.2 0.00013 21.1 17.2 1.6 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167457.1_09923001_1 - 5.9e-99 330.8 21.7 5.9e-99 330.8 21.7 1.4 2 0 0 2 2 2 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167457.1_09923001_1 - 0.32 9.9 28.5 0.79 8.6 28.5 1.9 1 1 0 1 1 1 0 Taste receptor protein (TAS2R) V1R PF03402.12 001167458.1_09923001_1 - 3.3e-99 331.7 22.5 3.3e-99 331.7 22.5 1.9 2 0 0 2 2 2 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167458.1_09923001_1 - 1.4 7.9 29.9 3.8 6.4 29.9 2.1 1 1 0 1 1 1 0 Taste receptor protein (TAS2R) V1R PF03402.12 001167459.1_09922001_1 - 1.2e-34 120.1 22.1 1.4e-34 119.8 22.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167459.1_09922001_1 - 4.2e-05 22.7 32.3 4.9e-05 22.5 32.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167459.1_09922001_1 - 0.0014 17.8 18.8 0.0019 17.4 18.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167460.1_09922001_1 - 8.4e-91 304.1 29.5 8.4e-91 304.1 29.5 1.6 2 0 0 2 2 2 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167460.1_09922001_1 - 2.4e-05 23.5 33.6 3.2e-05 23.1 33.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167460.1_09922001_1 - 0.0023 17.1 19.6 0.0034 16.5 19.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167461.1_09922001_1 - 8.6e-76 254.9 26.8 1.3e-75 254.3 26.8 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167461.1_09922001_1 - 5.8e-05 22.2 34.6 7.5e-05 21.8 34.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF3989 PF13150.4 001167461.1_09922001_1 - 0.59 9.8 4.1 0.13 11.9 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) V1R PF03402.12 001167462.1_09922001_1 - 2.6e-86 289.4 22.7 3.8e-86 288.9 22.7 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167462.1_09922001_1 - 0.00028 20.0 29.3 0.00037 19.6 29.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167462.1_09922001_1 - 0.068 12.3 17.1 0.11 11.6 17.1 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF3278 PF11683.6 001167462.1_09922001_1 - 1.5 8.8 13.6 0.22 11.5 2.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3278) V1R PF03402.12 001167463.1_09922001_1 - 1.3e-75 254.4 26.3 2.1e-75 253.6 26.3 1.3 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167463.1_09922001_1 - 0.00017 20.7 34.5 0.00022 20.3 34.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF3989 PF13150.4 001167463.1_09922001_1 - 0.026 14.1 0.3 0.082 12.5 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) V1R PF03402.12 001167464.1_09922001_1 - 4.3e-89 298.5 26.9 4.3e-89 298.5 26.9 1.5 2 0 0 2 2 2 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167464.1_09922001_1 - 6.3e-08 32.0 32.4 8.8e-08 31.5 32.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167464.1_09922001_1 - 0.00044 19.4 20.2 0.00064 18.9 20.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MotB_plug PF13677.4 001167464.1_09922001_1 - 2.6 7.6 10.9 0.07 12.6 2.4 2.5 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB V1R PF03402.12 001167465.1_09922001_1 - 4.2e-87 292.0 24.4 6.7e-87 291.3 24.4 1.3 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167465.1_09922001_1 - 8e-07 28.3 28.3 1.1e-06 27.9 28.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167465.1_09922001_1 - 0.0044 16.1 19.8 0.006 15.7 19.4 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3278 PF11683.6 001167465.1_09922001_1 - 8.9 6.3 16.6 0.64 10.0 2.7 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3278) V1R PF03402.12 001167466.1_09922001_1 - 2.6e-82 276.3 21.1 3.6e-82 275.8 21.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167466.1_09922001_1 - 0.64 9.1 18.6 0.97 8.5 18.6 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167467.1_09922001_1 - 1.1e-85 287.3 25.9 1.4e-85 287.0 25.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167467.1_09922001_1 - 0.054 12.5 35.7 0.072 12.1 35.7 1.1 1 0 0 1 1 1 0 Taste receptor protein (TAS2R) V1R PF03402.12 001167468.1_09922001_1 - 1.4e-80 270.6 21.6 1.7e-80 270.3 21.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167468.1_09922001_1 - 7e-05 21.9 26.4 0.00013 21.1 26.4 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) zf-C2HC5 PF06221.11 001167468.1_09922001_1 - 0.014 15.2 4.0 0.025 14.4 4.0 1.4 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type 7tm_1 PF00001.19 001167468.1_09922001_1 - 0.034 13.2 17.5 0.047 12.8 17.0 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167469.1_09922001_1 - 7e-82 274.9 20.5 1.1e-81 274.3 20.5 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167469.1_09922001_1 - 0.05 12.7 15.2 0.075 12.1 15.2 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167470.1_09922001_1 - 1.1e-80 271.0 30.1 1.4e-80 270.7 30.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167470.1_09922001_1 - 1.5e-05 24.2 22.8 2.2e-05 23.7 22.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167470.1_09922001_1 - 7.2e-05 21.9 34.5 9.1e-05 21.6 34.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167360.1_37922001_1 - 2.1e-56 191.4 29.7 2.5e-56 191.1 29.7 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167360.1_37922001_1 - 0.0018 17.5 27.7 0.0024 17.0 27.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167297.1_37922001_1 - 2.4e-37 128.9 11.8 3e-37 128.5 11.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167297.1_37922001_1 - 1.2e-06 27.7 9.8 1.5e-06 27.5 9.8 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167297.1_37922001_1 - 1.6e-06 27.4 9.3 2.9e-06 26.6 9.3 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167321.1_37922001_1 - 4.2e-34 118.2 11.3 5.8e-34 117.8 11.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167321.1_37922001_1 - 2.4e-05 23.5 10.8 2.9e-05 23.2 10.8 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167321.1_37922001_1 - 0.00012 21.3 9.1 0.00017 20.8 9.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167382.1_09922001_1 - 6.2e-32 111.1 16.9 8.4e-32 110.7 16.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167382.1_09922001_1 - 7.1e-09 35.1 21.7 8.4e-09 34.8 21.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167382.1_09922001_1 - 0.00052 19.2 13.8 0.00074 18.7 13.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2909 PF11137.6 001167382.1_09922001_1 - 1.2 9.0 5.5 17 5.3 1.0 3.5 2 2 0 2 2 2 0 Protein of unknown function (DUF2909) V1R PF03402.12 001167383.1_09922001_1 - 1.1e-27 97.1 18.3 1.5e-27 96.8 18.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167383.1_09922001_1 - 6.7e-10 38.4 23.5 8e-10 38.2 23.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167383.1_09922001_1 - 0.00041 19.5 16.2 0.00056 19.1 16.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TctB PF07331.9 001167383.1_09922001_1 - 8.4 6.5 17.4 1.3 9.2 3.6 2.8 2 1 0 3 3 3 0 Tripartite tricarboxylate transporter TctB family V1R PF03402.12 001167385.1_09922001_1 - 4.6e-89 298.4 13.5 5.9e-89 298.1 13.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167385.1_09922001_1 - 5.4e-05 22.3 21.0 7.9e-05 21.8 21.0 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) GPR_Gpa2_C PF11970.6 001167385.1_09922001_1 - 1.5 8.8 6.6 0.47 10.4 0.9 2.9 3 1 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term V1R PF03402.12 001167386.1_09922001_1 - 7.8e-90 300.9 15.6 1.1e-89 300.5 15.6 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167386.1_09922001_1 - 7.6e-08 31.7 21.6 9.3e-08 31.4 21.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167386.1_09922001_1 - 4.3 6.4 14.2 16 4.5 14.2 1.9 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167387.1_09922001_1 - 1.2e-28 100.4 18.8 1.5e-28 100.0 18.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167387.1_09922001_1 - 2e-10 40.2 24.0 2.3e-10 39.9 24.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167387.1_09922001_1 - 0.00041 19.5 17.3 0.00058 19.0 17.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TctB PF07331.9 001167387.1_09922001_1 - 5.5 7.1 17.9 0.98 9.6 2.9 3.0 2 1 1 3 3 3 0 Tripartite tricarboxylate transporter TctB family V1R PF03402.12 001167388.1_09922001_1 - 2e-30 106.2 10.8 2.6e-30 105.8 10.8 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167388.1_09922001_1 - 8.3e-05 21.8 5.1 0.00012 21.3 5.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167389.1_09923001_1 - 1.5e-98 329.5 21.9 1.5e-98 329.5 21.9 1.8 2 0 0 2 2 2 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167389.1_09923001_1 - 0.2 10.6 27.4 0.58 9.1 27.4 2.1 1 1 0 1 1 1 0 Taste receptor protein (TAS2R) V1R PF03402.12 001167390.1_09922001_1 - 2.1e-25 89.7 14.9 3e-25 89.2 14.9 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167390.1_09922001_1 - 4.6e-09 35.7 23.5 5.5e-09 35.4 23.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TRIQK PF15168.4 001167390.1_09922001_1 - 0.58 10.0 0.0 0.58 10.0 0.0 2.6 3 0 0 3 3 3 0 Triple QxxK/R motif-containing protein family V1R PF03402.12 001167391.1_09922001_1 - 1e-22 80.9 17.3 1.4e-22 80.5 17.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167391.1_09922001_1 - 1.9e-06 27.1 23.3 2.7e-06 26.6 23.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167392.1_09922001_1 - 5e-86 288.5 23.1 6.1e-86 288.2 23.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167392.1_09922001_1 - 5.2e-07 28.9 29.5 7.6e-07 28.4 29.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MotB_plug PF13677.4 001167392.1_09922001_1 - 2.4 7.7 5.3 12 5.4 5.5 2.0 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB V1R PF03402.12 001167393.1_09922001_1 - 2.5e-86 289.5 15.0 3.2e-86 289.1 15.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167393.1_09922001_1 - 3.1e-07 29.7 22.4 4e-07 29.3 22.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167393.1_09922001_1 - 0.015 14.4 13.2 0.025 13.7 13.2 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167394.1_09922001_1 - 1.9e-88 296.4 22.1 2.4e-88 296.1 22.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167394.1_09922001_1 - 2.7e-08 33.2 29.6 3.7e-08 32.7 29.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167395.1_09922001_1 - 8.4e-87 291.0 17.0 1.2e-86 290.5 17.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167395.1_09922001_1 - 2.6e-05 23.4 25.3 3.7e-05 22.8 25.3 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167396.1_09922001_1 - 2.6e-29 102.6 14.1 3.3e-29 102.2 14.1 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167396.1_09922001_1 - 2.8e-10 39.7 14.3 3.1e-10 39.5 14.3 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167396.1_09922001_1 - 8e-05 21.9 17.9 0.00013 21.2 17.8 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167397.1_09922001_1 - 2e-27 96.4 18.3 2.6e-27 96.0 18.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167397.1_09922001_1 - 6.2e-10 38.5 24.1 7.4e-10 38.3 24.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167398.1_09922001_1 - 2.7e-29 102.5 17.6 3.6e-29 102.1 17.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167398.1_09922001_1 - 3.7e-09 36.0 23.7 4.4e-09 35.7 23.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167398.1_09922001_1 - 0.00022 20.4 17.5 0.0003 20.0 17.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1077 PF06417.10 001167398.1_09922001_1 - 8.9 6.2 7.2 1.9 8.4 2.0 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1077) V1R PF03402.12 001167399.1_09922001_1 - 1.7e-27 96.6 18.8 2.2e-27 96.2 18.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167399.1_09922001_1 - 9.8e-10 37.9 24.2 1.2e-09 37.6 24.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167399.1_09922001_1 - 0.0014 17.8 17.5 0.002 17.3 17.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) BRI3BP PF14965.4 001167399.1_09922001_1 - 1.5 8.1 5.8 0.51 9.7 0.5 2.7 3 0 0 3 3 3 0 Negative regulator of p53/TP53 V1R PF03402.12 001167400.1_09922001_1 - 1.4e-29 103.4 16.8 1.8e-29 103.0 16.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167400.1_09922001_1 - 9.4e-10 37.9 24.6 1.2e-09 37.6 24.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167401.1_09922001_1 - 1.2e-26 93.8 21.4 1.6e-26 93.4 21.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167401.1_09922001_1 - 9e-05 21.6 29.7 0.00011 21.3 29.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167401.1_09922001_1 - 0.00041 19.5 21.5 0.00054 19.2 21.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) BRI3BP PF14965.4 001167401.1_09922001_1 - 0.011 15.1 2.5 0.021 14.2 1.1 2.1 2 0 0 2 2 2 0 Negative regulator of p53/TP53 DUF454 PF04304.11 001167401.1_09922001_1 - 4.9 7.1 11.1 0.28 11.0 2.8 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF454) V1R PF03402.12 001167402.1_09922001_1 - 6.8e-28 97.9 14.9 9.6e-28 97.4 14.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167402.1_09922001_1 - 4.9e-09 35.6 23.4 5.8e-09 35.3 23.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167403.1_09922001_1 - 5.1e-27 95.0 14.9 7.3e-27 94.5 14.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167403.1_09922001_1 - 2.1e-08 33.5 22.5 2.5e-08 33.3 22.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167404.1_09922001_1 - 1.7e-40 139.2 19.5 2.1e-40 138.9 19.5 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167404.1_09922001_1 - 2.1e-06 26.9 24.6 2.7e-06 26.6 24.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167404.1_09922001_1 - 2.2e-05 23.7 17.4 3e-05 23.3 17.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GP4 PF03010.12 001167404.1_09922001_1 - 0.017 14.9 0.4 0.043 13.6 0.4 1.7 1 0 0 1 1 1 0 GP4 V1R PF03402.12 001167405.1_09922001_1 - 1e-28 100.5 11.4 1.4e-28 100.1 11.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167405.1_09922001_1 - 1.5e-09 37.3 16.9 1.8e-09 37.0 16.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167405.1_09922001_1 - 2.2e-07 30.3 13.0 3e-07 29.8 13.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167406.1_09922001_1 - 6e-32 111.2 14.5 7.6e-32 110.8 14.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167406.1_09922001_1 - 1.7e-08 33.9 14.8 2.1e-08 33.6 14.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167406.1_09922001_1 - 9.9e-08 31.3 18.1 1.1e-07 31.1 18.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF2975 PF11188.6 001167406.1_09922001_1 - 0.1 12.4 2.3 0.27 11.0 0.7 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2975) V1R PF03402.12 001167407.1_09922001_1 - 4.6e-32 111.5 16.0 5.8e-32 111.2 16.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167407.1_09922001_1 - 7.9e-08 31.7 16.8 1e-07 31.4 16.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167407.1_09922001_1 - 1e-06 27.9 21.6 1.2e-06 27.7 21.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF2975 PF11188.6 001167407.1_09922001_1 - 0.071 12.9 1.9 0.19 11.5 0.8 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2975) V1R PF03402.12 001167408.1_09922001_1 - 1.8e-32 112.9 11.8 2.5e-32 112.4 11.8 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167408.1_09922001_1 - 2.3e-08 33.4 18.4 2.7e-08 33.1 18.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167408.1_09922001_1 - 6.3e-07 28.8 11.6 8.6e-07 28.3 11.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167409.1_09922001_1 - 1.2e-30 106.9 12.3 1.7e-30 106.4 12.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167409.1_09922001_1 - 1.2e-08 34.3 21.7 1.4e-08 34.1 21.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167410.1_09922001_1 - 1.1e-31 110.4 14.4 1.5e-31 109.9 14.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167410.1_09922001_1 - 3.8e-11 42.5 17.5 4.6e-11 42.2 17.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167411.1_09922001_1 - 5.2e-34 117.9 13.8 6.9e-34 117.5 13.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167411.1_09922001_1 - 7.3e-12 44.9 15.5 8.8e-12 44.6 15.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167411.1_09922001_1 - 0.00039 19.6 13.1 0.00059 19.0 13.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167412.1_09922001_1 - 1.8e-34 119.4 13.8 2.5e-34 119.0 13.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167412.1_09922001_1 - 1.4e-09 37.3 14.7 1.7e-09 37.1 14.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167414.1_09922001_1 - 8.5e-33 114.0 12.2 1.1e-32 113.6 12.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167414.1_09922001_1 - 2.2e-11 43.3 14.6 2.5e-11 43.1 14.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167416.1_09922001_1 - 1.4e-31 110.0 13.8 1.8e-31 109.6 13.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167416.1_09922001_1 - 7.2e-09 35.0 14.1 8.5e-09 34.8 14.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167416.1_09922001_1 - 3.6e-06 26.3 11.8 5e-06 25.8 11.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Pex24p PF06398.9 001167416.1_09922001_1 - 0.028 13.3 4.3 0.039 12.8 4.3 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin SYS1 PF09801.7 001167416.1_09922001_1 - 0.057 13.5 0.2 0.057 13.5 0.2 2.7 3 0 0 3 3 3 0 Integral membrane protein S linking to the trans Golgi network V1R PF03402.12 001167417.1_09922001_1 - 5.9e-35 121.0 12.2 8e-35 120.6 12.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167417.1_09922001_1 - 2.4e-11 43.2 14.1 2.9e-11 42.9 14.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) AA_permease_2 PF13520.4 001167417.1_09922001_1 - 2.7e-05 23.1 6.2 3.5e-05 22.7 6.2 1.2 1 0 0 1 1 1 1 Amino acid permease 7tm_1 PF00001.19 001167417.1_09922001_1 - 0.00023 20.4 11.1 0.00046 19.4 11.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SYS1 PF09801.7 001167417.1_09922001_1 - 6.2 6.9 10.1 0.23 11.5 0.8 2.8 2 2 0 2 2 2 0 Integral membrane protein S linking to the trans Golgi network V1R PF03402.12 001167419.1_09922001_1 - 9.7e-25 87.5 22.9 1.4e-24 87.1 22.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167419.1_09922001_1 - 0.058 12.4 30.6 0.08 11.9 30.6 1.2 1 0 0 1 1 1 0 Taste receptor protein (TAS2R) V1R PF03402.12 001167420.1_09923001_1 - 1.3e-27 97.0 22.4 1.9e-27 96.4 22.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167420.1_09923001_1 - 4.2e-06 26.1 17.8 5.7e-06 25.6 17.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167420.1_09923001_1 - 0.2 10.6 30.7 0.29 10.1 30.7 1.1 1 0 0 1 1 1 0 Taste receptor protein (TAS2R) V1R PF03402.12 001167421.1_09922001_1 - 3.6e-21 75.8 26.8 4.8e-21 75.4 26.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167421.1_09922001_1 - 0.0079 15.3 18.3 0.01 15.0 18.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167421.1_09922001_1 - 0.0093 15.0 31.2 0.017 14.1 31.2 1.4 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) Bac_export_2 PF01312.17 001167421.1_09922001_1 - 8.5 5.3 8.8 2.5 7.1 0.7 2.3 2 1 0 2 2 2 0 FlhB HrpN YscU SpaS Family V1R PF03402.12 001167422.1_09922001_1 - 2.2e-24 86.4 17.1 3.4e-24 85.8 17.1 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167422.1_09922001_1 - 6.5e-06 25.3 22.4 9.4e-06 24.8 22.4 1.3 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167422.1_09922001_1 - 0.00018 20.7 15.3 0.00025 20.2 15.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF373 PF04123.11 001167422.1_09922001_1 - 0.37 10.1 13.9 0.14 11.5 8.2 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF373) V1R PF03402.12 001167423.1_09922001_1 - 7.4e-22 78.1 17.4 1.2e-21 77.4 17.4 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R DUF373 PF04123.11 001167423.1_09922001_1 - 0.63 9.3 11.2 0.48 9.7 5.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF373) V1R PF03402.12 001167424.1_09922001_1 - 2.3e-23 83.1 18.4 3.1e-23 82.6 18.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167424.1_09922001_1 - 0.00026 20.1 24.6 0.00033 19.7 24.6 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) V1R PF03402.12 001167425.1_09922001_1 - 1e-29 103.9 16.2 2e-29 102.9 16.2 1.4 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167425.1_09922001_1 - 7.4e-07 28.4 17.1 1.2e-06 27.8 17.1 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167425.1_09922001_1 - 2.1e-06 27.0 13.8 2.9e-06 26.6 13.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Pex24p PF06398.9 001167425.1_09922001_1 - 0.016 14.1 7.4 0.024 13.5 7.4 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin PRA1 PF03208.17 001167425.1_09922001_1 - 4.7 6.7 17.2 0.034 13.6 6.3 2.5 2 1 1 3 3 3 0 PRA1 family protein V1R PF03402.12 001167426.1_09922001_1 - 3.4e-20 72.7 22.3 4.4e-20 72.3 22.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167426.1_09922001_1 - 1.9e-09 37.0 30.7 2.2e-09 36.8 30.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167426.1_09922001_1 - 0.13 11.3 25.7 0.21 10.7 25.4 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) LRR19-TM PF15176.4 001167426.1_09922001_1 - 1.4 8.8 3.1 0.61 10.0 0.3 1.8 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain V1R PF03402.12 001167427.1_09922001_1 - 4.3e-29 101.8 10.9 5.9e-29 101.4 10.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167427.1_09922001_1 - 1e-05 24.7 16.9 1.4e-05 24.3 16.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TrbL PF04610.12 001167427.1_09922001_1 - 0.0035 17.0 3.7 0.0081 15.8 3.7 1.5 1 0 0 1 1 1 1 TrbL/VirB6 plasmid conjugal transfer protein 7tm_1 PF00001.19 001167427.1_09922001_1 - 2.6 7.1 14.1 5.8 5.9 14.1 1.8 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167428.1_09922001_1 - 2.6e-37 128.8 15.1 3.3e-37 128.4 15.1 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167428.1_09922001_1 - 3.1e-09 36.2 22.4 4.4e-09 35.7 22.4 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167428.1_09922001_1 - 5.3 6.1 13.1 14 4.7 12.9 1.9 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167429.1_09922001_1 - 3.7e-34 118.4 7.9 4.5e-34 118.1 7.9 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R GP4 PF03010.12 001167429.1_09922001_1 - 0.0069 16.2 0.1 0.014 15.2 0.1 1.4 1 0 0 1 1 1 1 GP4 V1R PF03402.12 001167430.1_09922001_1 - 1.5e-34 119.7 14.1 1.9e-34 119.4 14.1 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167430.1_09922001_1 - 0.0015 17.6 14.5 0.0021 17.2 14.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167431.1_09922001_1 - 2e-35 122.6 13.2 2.7e-35 122.2 13.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R V1R PF03402.12 001167432.1_09922001_1 - 1.5e-29 103.4 12.2 1.9e-29 103.0 12.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167432.1_09922001_1 - 1.5e-05 24.1 18.2 2e-05 23.8 18.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167432.1_09922001_1 - 2.2 7.3 14.5 5.1 6.1 14.5 1.8 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167433.1_09922001_1 - 1.4e-37 129.6 14.8 1.8e-37 129.3 14.8 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167433.1_09922001_1 - 5.8e-09 35.3 18.5 7.6e-09 35.0 18.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167433.1_09922001_1 - 0.17 11.0 10.9 0.28 10.2 10.9 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167434.1_09922001_1 - 4.8e-38 131.2 12.3 5.8e-38 130.9 12.3 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167434.1_09922001_1 - 0.00013 21.1 12.6 0.00021 20.5 12.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167435.1_09922001_1 - 1.5e-31 109.9 10.6 1.8e-31 109.6 10.6 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R GP4 PF03010.12 001167435.1_09922001_1 - 0.0062 16.3 0.2 0.012 15.4 0.2 1.4 1 0 0 1 1 1 1 GP4 V1R PF03402.12 001167436.1_09922001_1 - 1.8e-35 122.7 13.4 2.2e-35 122.4 13.4 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167436.1_09922001_1 - 1.1e-09 37.7 18.5 1.6e-09 37.2 18.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167436.1_09922001_1 - 8.8 5.3 12.9 13 4.8 12.2 1.9 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) V1R PF03402.12 001167437.1_09922001_1 - 4.6e-35 121.4 11.7 5.9e-35 121.0 11.7 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R DUF2515 PF10720.7 001167437.1_09922001_1 - 0.065 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2515) V1R PF03402.12 001167438.1_09922001_1 - 1.2e-34 120.0 13.9 1.6e-34 119.6 13.9 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167438.1_09922001_1 - 2.5e-06 26.7 20.2 1.2e-05 24.5 20.2 1.8 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) ATP-synt PF00231.17 001169088.1_40422001_1 - 2.5e-38 132.3 1.4 2.7e-38 132.2 1.4 1.0 1 0 0 1 1 1 1 ATP synthase FAA_hydrolase PF01557.16 001260690.1_29622001_1 - 5.8e-63 212.3 0.0 6.9e-63 212.1 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Gag_spuma PF03276.12 001260690.1_29622001_3 - 0.00052 18.5 4.4 0.00067 18.1 4.4 1.1 1 0 0 1 1 1 1 Spumavirus gag protein zf-C2H2 PF00096.24 003547.2_32923120_2 - 1.8e-18 65.8 11.6 7.5e-06 26.0 0.2 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 003547.2_32923120_2 - 1.4e-17 63.1 10.1 1.5e-08 34.6 0.3 4.4 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 003547.2_32923120_2 - 3.6e-10 39.7 11.7 0.0076 16.9 1.9 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-LYAR PF08790.9 003547.2_32923120_2 - 0.00011 21.9 4.6 3.2 7.6 0.0 3.5 3 0 0 3 3 3 3 LYAR-type C2HC zinc finger Zn-ribbon_8 PF09723.8 003547.2_32923120_2 - 0.00081 19.3 5.0 0.01 15.8 0.9 2.7 1 1 1 2 2 2 2 Zinc ribbon domain zf-C2H2_jaz PF12171.6 003547.2_32923120_2 - 0.0014 18.8 4.3 1.4 9.2 0.0 3.6 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 003547.2_32923120_2 - 0.0045 16.6 13.1 0.81 9.4 0.1 4.1 4 0 0 4 4 4 3 zinc-finger C2H2-type XPA_N PF01286.16 003547.2_32923120_2 - 0.0052 16.7 4.1 2.4 8.1 0.1 3.4 3 0 0 3 3 3 2 XPA protein N-terminal DZR PF12773.5 003547.2_32923120_2 - 0.021 14.7 5.2 0.62 10.0 5.2 2.6 1 1 0 1 1 1 0 Double zinc ribbon zf-BED PF02892.13 003547.2_32923120_2 - 0.061 13.3 9.1 3.5 7.6 2.3 3.4 1 1 2 3 3 3 0 BED zinc finger zf-C2H2_6 PF13912.4 003547.2_32923120_2 - 0.076 12.9 9.6 8.4 6.3 0.1 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger SprT-like PF10263.7 003547.2_32923120_2 - 0.14 11.9 9.3 0.63 9.7 1.1 2.2 1 1 0 2 2 2 0 SprT-like family TFIIS_C PF01096.16 003547.2_32923120_2 - 0.5 10.1 7.6 16 5.3 0.1 3.4 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) C1_4 PF07975.10 003547.2_32923120_2 - 0.56 10.4 5.7 1.6 8.9 2.3 2.5 1 1 2 3 3 3 0 TFIIH C1-like domain zf-Mss51 PF13824.4 003547.2_32923120_2 - 1.6 8.8 14.4 3e+03 -1.7 12.8 3.8 2 1 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 YhfH PF14149.4 003547.2_32923120_2 - 1.7 8.6 8.4 23 4.9 0.2 3.7 4 0 0 4 4 4 0 YhfH-like protein SCAN PF02023.15 003547.2_32923120_3 - 9.1e-17 60.6 0.8 1.6e-16 59.8 0.8 1.4 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 003547.2_32923120_3 - 0.002 18.4 1.4 0.002 18.4 1.4 2.5 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 003547.2_32923120_3 - 0.035 13.9 1.4 0.069 13.0 1.4 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_4 PF13894.4 003547.2_32923120_3 - 0.14 13.0 1.2 0.57 11.0 1.2 2.2 1 0 0 1 1 1 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 003547.2_32923120_3 - 0.98 9.9 4.7 19 5.8 0.0 3.1 3 0 0 3 3 3 0 Zinc-finger double domain POM121 PF15229.4 040117.1_26223120_1 - 1.5e-25 90.2 5.8 2.1e-25 89.7 5.8 1.1 1 0 0 1 1 1 1 POM121 family Ribosomal_L37ae PF01780.17 038113.1_45721120_2 - 2.2e-47 158.9 11.2 2.6e-47 158.7 11.2 1.1 1 0 0 1 1 1 1 Ribosomal L37ae protein family Rsm1 PF08600.8 038113.1_45721120_2 - 0.028 14.4 0.8 0.039 14.0 0.8 1.3 1 0 0 1 1 1 0 Rsm1-like Zn_Tnp_IS1595 PF12760.5 038113.1_45721120_2 - 0.063 13.1 1.6 0.1 12.4 1.6 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-C4_ClpX PF06689.11 038113.1_45721120_2 - 0.14 11.9 3.6 0.38 10.5 3.6 1.8 1 1 0 1 1 1 0 ClpX C4-type zinc finger TGF_beta PF00019.18 037587.1_37923120_1 - 4.9e-24 85.1 0.0 7.4e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain QueC PF06508.11 037587.1_37923120_3 - 6.7 6.0 5.0 1.5 8.1 0.2 1.9 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC 7tm_4 PF13853.4 001279642.1_24222001_1 - 2.4e-51 175.0 20.6 2.8e-51 174.8 20.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001279642.1_24222001_1 - 2.6e-24 85.8 24.7 5.8e-24 84.6 24.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001279642.1_24222001_1 - 2e-05 24.0 19.9 3.1e-05 23.3 19.9 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001279642.1_24222001_1 - 0.00036 19.8 18.1 0.00049 19.4 18.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx CPP1-like PF11833.6 001279642.1_24222001_1 - 5.5 6.4 7.9 0.32 10.5 2.0 1.9 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Lipocalin PF00061.21 001281561.1_31322001_3 - 6.8e-19 68.4 2.7 8.2e-19 68.1 2.7 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lectin_C PF00059.19 001281563.1_31322001_2 - 6.1e-21 75.1 2.1 8.4e-21 74.6 2.1 1.2 1 0 0 1 1 1 1 Lectin C-type domain DUF846 PF05832.10 001281857.1_22422001_3 - 3.1e-56 189.1 9.6 4e-56 188.8 9.6 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) TMC PF07810.11 001281857.1_22422001_3 - 0.068 13.6 2.6 0.13 12.8 2.6 1.6 1 1 0 1 1 1 0 TMC domain Linker_histone PF00538.17 001031792.2_49822001_1 - 3.9e-24 84.7 0.6 1.4e-23 82.9 0.6 2.0 1 0 0 1 1 1 1 linker histone H1 and H5 family Asp PF00026.21 001009792.2_39523001_3 - 3.9e-97 325.3 0.0 4.8e-97 325.0 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001009792.2_39523001_3 - 3.5e-15 56.6 0.3 1.5e-12 48.0 0.3 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001009792.2_39523001_3 - 2.7e-11 42.9 0.7 5.1e-11 42.1 0.7 1.5 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.4 001009792.2_39523001_3 - 0.00057 20.4 0.1 0.43 11.2 0.0 3.3 2 1 0 2 2 2 2 Aspartyl protease Peptidase_C1_2 PF03051.13 001009792.2_39523001_3 - 0.097 11.3 0.0 0.13 10.9 0.0 1.1 1 0 0 1 1 1 0 Peptidase C1-like family EOS1 PF12326.6 001133597.2_43523001_1 - 0.23 11.2 3.6 0.29 10.9 3.6 1.3 1 0 0 1 1 1 0 N-glycosylation protein Presenilin PF01080.15 001133597.2_43523001_1 - 2.4 6.7 8.5 2.8 6.5 8.5 1.1 1 0 0 1 1 1 0 Presenilin RNA_pol_Rpc4 PF05132.12 001133597.2_43523001_2 - 0.00038 20.8 3.6 0.00049 20.4 3.6 1.2 1 0 0 1 1 1 1 RNA polymerase III RPC4 EOS1 PF12326.6 001133597.2_43523001_2 - 1.9 8.2 5.2 2.4 7.9 5.2 1.1 1 0 0 1 1 1 0 N-glycosylation protein Kunitz_BPTI PF00014.21 001133597.2_43523001_3 - 1.6e-33 114.6 21.4 5.9e-17 61.5 4.0 2.5 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Lipocalin PF00061.21 001133597.2_43523001_3 - 1.2e-29 103.3 0.1 1.2e-29 103.3 0.1 2.1 2 0 0 2 2 2 1 Lipocalin / cytosolic fatty-acid binding protein family EOS1 PF12326.6 001133597.2_43523001_3 - 0.036 13.9 0.3 0.042 13.6 0.3 1.3 1 0 0 1 1 1 0 N-glycosylation protein LRR_8 PF13855.4 001131174.2_43524001_2 - 5.2e-35 118.9 29.6 1.7e-10 40.4 3.9 6.7 4 2 2 6 6 6 5 Leucine rich repeat LRR_4 PF12799.5 001131174.2_43524001_2 - 3.6e-21 74.7 31.6 2.7e-07 30.6 0.1 6.8 1 1 9 10 10 10 8 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 001131174.2_43524001_2 - 3.5e-10 39.0 16.4 0.62 10.1 0.0 8.8 9 0 0 9 9 9 4 Leucine Rich repeat LRR_1 PF00560.31 001131174.2_43524001_2 - 4.9e-09 35.3 19.1 7.5 7.3 0.1 9.6 7 3 1 8 8 8 3 Leucine Rich Repeat LRRNT PF01462.16 001131174.2_43524001_2 - 2.9e-08 33.0 3.3 9.6e-08 31.4 3.3 2.0 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 001131174.2_43524001_2 - 6.6e-08 32.1 8.8 0.067 12.6 0.7 3.7 1 1 3 4 4 4 3 Leucine-rich repeat LRR_5 PF13306.4 001131174.2_43524001_2 - 2.1e-06 27.6 4.9 0.0072 16.1 0.1 3.5 1 1 2 4 4 4 3 Leucine rich repeats (6 copies) 7tm_1 PF00001.19 001160285.2_37923001_1 - 2.2e-46 158.1 8.6 2.7e-46 157.8 8.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001160285.2_37923001_1 - 1.3e-11 44.2 18.6 3.6e-09 36.2 10.4 2.5 2 1 1 3 3 3 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001160285.2_37923001_1 - 0.00055 19.2 12.2 0.00055 19.2 12.2 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.7 001160285.2_37923001_1 - 0.0011 18.2 14.1 0.0012 18.1 10.9 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw LBP_BPI_CETP PF01273.23 001040415.2_29622001_2 - 1.5e-11 44.0 0.3 2.2e-11 43.5 0.3 1.3 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain SH2 PF00017.22 001194326.1_29623001_2 - 9e-10 38.4 0.0 1.5e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.14 001194326.1_29623001_2 - 5.3e-05 23.4 0.0 0.00018 21.6 0.0 2.0 1 0 0 1 1 1 1 SOCS box PRY PF13765.4 001173114.1_09924001_1 - 1.1e-17 63.2 0.1 4.2e-17 61.3 0.0 2.1 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.26 001173114.1_09924001_1 - 1.8e-13 50.5 0.1 4.4e-13 49.3 0.1 1.6 1 0 0 1 1 1 1 SPRY domain HALZ PF02183.16 001173114.1_09924001_1 - 1.4 9.0 56.4 0.084 13.0 1.1 9.9 6 4 5 11 11 11 0 Homeobox associated leucine zipper CENP-F_leu_zip PF10473.7 001173114.1_09924001_1 - 4.5 7.2 79.7 4.6 7.1 2.6 5.0 1 1 4 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1324 PF07038.9 001173114.1_09924001_3 - 0.085 13.0 0.1 0.15 12.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1324) Adhes-Ig_like PF09085.8 001038020.1_39524001_1 - 2.3e-52 175.7 0.2 3.6e-52 175.0 0.2 1.3 1 0 0 1 1 1 1 Adhesion molecule, immunoglobulin-like Glutaredoxin PF00462.22 001127288.1_39521001_1 - 6.7e-18 64.5 0.1 9.7e-18 64.0 0.1 1.2 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.12 001127288.1_39521001_1 - 0.00029 21.1 0.0 0.00037 20.7 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.4 001127288.1_39521001_1 - 0.00053 20.3 0.1 0.00066 20.0 0.1 1.3 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_3 PF13192.4 001127288.1_39521001_1 - 0.0022 17.8 0.0 0.0046 16.8 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin domain Thioredoxin_4 PF13462.4 001127288.1_39521001_1 - 0.027 14.5 0.1 0.068 13.2 0.1 1.6 1 1 1 2 2 2 0 Thioredoxin TraF PF13728.4 001127288.1_39521001_1 - 0.046 13.4 0.0 0.057 13.1 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein Redoxin PF08534.8 001127288.1_39521001_1 - 0.12 11.9 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Redoxin GST_N_3 PF13417.4 001127288.1_39521001_1 - 0.14 12.4 0.0 0.22 11.8 0.0 1.4 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain UQ_con PF00179.24 001134307.1_39522001_1 - 1.7e-46 157.2 0.0 2.2e-46 156.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.4 001134307.1_39522001_1 - 0.0074 15.9 0.0 0.0097 15.5 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.20 001134307.1_39522001_1 - 0.025 14.7 0.1 0.035 14.3 0.1 1.3 1 0 0 1 1 1 0 RWD domain Lbh PF15317.4 001134307.1_39522001_2 - 0.012 16.3 0.0 0.017 15.8 0.0 1.3 1 0 0 1 1 1 0 Cardiac transcription factor regulator, Developmental protein DUF1658 PF07871.9 001134307.1_39522001_2 - 4.6 7.2 6.8 6.8 6.7 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1658) MHC_I PF00129.16 001305900.1_29723001_2 - 1.3e-94 314.6 1.2 1.8e-94 314.2 1.2 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001305900.1_29723001_2 - 1.8e-16 60.2 0.0 3.3e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001305900.1_29723001_2 - 3.4e-14 52.3 10.9 5.9e-14 51.6 10.9 1.4 1 0 0 1 1 1 1 MHC_I C-terminus C2-set_2 PF08205.10 001305900.1_29723001_2 - 0.00011 22.1 0.3 0.00023 21.0 0.3 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 001305900.1_29723001_2 - 0.00017 22.0 0.3 0.004 17.6 0.1 2.4 1 1 1 2 2 2 1 Immunoglobulin domain MHC_I_3 PF16497.3 001305900.1_29723001_2 - 0.00025 20.5 0.0 0.00037 19.9 0.0 1.3 1 0 0 1 1 1 1 MHC-I family domain ig PF00047.23 001305900.1_29723001_2 - 0.026 14.5 0.1 0.073 13.1 0.1 1.7 1 0 0 1 1 1 0 Immunoglobulin domain Podoplanin PF05808.9 001305900.1_29723001_2 - 0.17 11.8 1.0 0.41 10.6 1.0 1.5 1 0 0 1 1 1 0 Podoplanin adh_short PF00106.23 001306107.1_39522001_1 - 6e-42 143.2 0.0 8e-42 142.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001306107.1_39522001_1 - 1.5e-26 93.3 0.0 2e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001306107.1_39522001_1 - 7.6e-05 22.6 0.5 0.00023 21.0 0.5 1.9 1 1 0 1 1 1 1 KR domain Epimerase PF01370.19 001306107.1_39522001_1 - 9.7e-05 21.8 0.5 0.0054 16.1 0.1 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.4 001306107.1_39522001_1 - 0.0026 17.6 0.1 0.004 16.9 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding SNF5 PF04855.10 001306107.1_39522001_1 - 0.04 13.5 0.0 0.073 12.7 0.0 1.3 1 0 0 1 1 1 0 SNF5 / SMARCB1 / INI1 Ald_Xan_dh_C2 PF02738.16 001308436.1_40429001_1 - 4e-178 593.2 0.0 5.3e-178 592.7 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase Ald_Xan_dh_C PF01315.20 001308436.1_40429001_1 - 8.6e-30 103.2 2.2 1.7e-29 102.2 1.4 1.9 2 0 0 2 2 2 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 001308436.1_40429001_1 - 8.6e-30 102.4 0.3 2.2e-29 101.1 0.3 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 001308436.1_40429001_1 - 9.6e-29 99.5 0.0 9e-28 96.3 0.0 2.5 3 0 0 3 3 3 1 CO dehydrogenase flavoprotein C-terminal domain FAD_binding_5 PF00941.19 001308436.1_40429001_1 - 2.7e-14 53.1 0.0 1.3e-09 37.9 0.0 2.5 1 1 1 2 2 2 2 FAD binding domain in molybdopterin dehydrogenase Fer2 PF00111.25 001308436.1_40429001_1 - 3.7e-08 33.1 0.8 3.8e-07 29.8 0.1 2.8 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Androgen_recep PF02166.14 001308584.1_39526001_1 - 3.5e-231 768.0 37.2 5.8e-231 767.3 37.2 1.3 1 0 0 1 1 1 1 Androgen receptor Hormone_recep PF00104.28 001308584.1_39526001_1 - 2.7e-31 108.6 2.9 4.7e-31 107.9 2.9 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001308584.1_39526001_1 - 4.2e-27 94.3 14.4 8.2e-27 93.3 14.4 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) AIRS_C PF02769.20 001190418.1_29627001_2 - 3.8e-30 105.0 0.1 5.3e-30 104.5 0.1 1.2 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.22 001190418.1_29627001_2 - 4.8e-10 39.8 0.3 1.1e-09 38.7 0.3 1.5 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain Hormone_6 PF00236.16 001194654.1_29622001_1 - 0.00064 19.5 5.3 0.0012 18.7 5.3 1.4 1 0 0 1 1 1 1 Glycoprotein hormone DAN PF03045.13 001194654.1_29622001_1 - 0.0038 17.1 9.7 0.0055 16.6 9.7 1.2 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.20 001194654.1_29622001_1 - 0.0089 16.2 8.2 0.014 15.5 8.2 1.3 1 0 0 1 1 1 1 Cystine-knot domain CH_2 PF06294.9 001194681.1_29623001_2 - 3.2e-32 110.4 0.0 5.3e-32 109.7 0.0 1.4 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.6 001194681.1_29623001_2 - 3.3e-14 52.3 0.0 5.6e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain CH PF00307.29 001194681.1_29623001_2 - 0.11 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Calponin homology (CH) domain DUF641 PF04859.10 001194681.1_29623001_2 - 0.13 12.4 2.4 0.26 11.5 2.4 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) REPA_OB_2 PF16900.3 001193903.1_29624001_2 - 7.3e-09 35.3 0.1 2.8e-06 27.0 0.1 2.6 2 0 0 2 2 2 2 Replication protein A OB domain DZR PF12773.5 001193903.1_29624001_2 - 0.04 13.8 0.1 0.11 12.4 0.1 1.8 1 0 0 1 1 1 0 Double zinc ribbon Pox_H7 PF04787.10 001193903.1_29624001_2 - 0.12 12.8 0.1 0.2 12.1 0.1 1.3 1 0 0 1 1 1 0 Late protein H7 DnaJ PF00226.29 001204971.1_29625001_2 - 3.2e-19 68.7 0.1 7.8e-19 67.4 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain Interferon PF00143.17 001102441.1_22422001_1 - 1.1e-54 184.8 0.0 1.3e-54 184.6 0.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Tim17 PF02466.17 033149.1_26229120_1 - 4.1e-07 30.2 0.1 9.4e-07 29.0 0.1 1.5 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family TMEM135_C_rich PF15982.3 033149.1_26229120_2 - 3.2e-59 199.1 0.2 6.2e-59 198.2 0.2 1.4 1 0 0 1 1 1 1 N-terminal cysteine-rich region of Transmembrane protein 135 Pup PF05639.9 131949.1_32922120_3 - 2.9 8.7 8.5 0.65 10.8 2.0 2.6 2 1 0 2 2 2 0 Pup-like protein Interferon PF00143.17 001009851.1_22422001_1 - 2.4e-56 190.2 0.1 2.7e-56 190.1 0.1 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain HSP70 PF00012.18 001267874.1_39524001_1 - 3.6e-263 874.1 3.5 4.1e-263 873.9 3.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 001267874.1_39524001_1 - 2.3e-16 59.4 0.1 1.4e-14 53.5 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.4 001267874.1_39524001_1 - 0.00035 20.8 1.4 4.9 7.5 0.0 3.7 3 1 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.14 001267874.1_39524001_1 - 0.0083 15.7 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.8 001267874.1_39524001_1 - 0.054 12.3 0.3 0.18 10.6 0.2 1.8 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.16 001267874.1_39524001_1 - 0.11 11.6 1.3 0.3 10.2 0.2 2.2 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase Pox_D5 PF03288.14 001267874.1_39524001_1 - 0.13 12.7 0.3 0.43 11.0 0.1 1.9 2 0 0 2 2 2 0 Poxvirus D5 protein-like Radial_spoke_3 PF06098.9 001267874.1_39524001_1 - 1 8.4 9.2 0.11 11.6 4.8 1.5 2 0 0 2 2 2 0 Radial spoke protein 3 MHC_I PF00129.16 001309025.1_29723001_2 - 2.7e-92 307.1 1.0 4.1e-92 306.5 1.0 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001309025.1_29723001_2 - 4.4e-18 65.4 0.1 1e-17 64.2 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001309025.1_29723001_2 - 9.1e-15 54.2 8.7 1.7e-14 53.3 8.7 1.5 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001309025.1_29723001_2 - 4.2e-06 27.1 0.5 0.013 16.0 0.0 2.6 1 1 1 2 2 2 2 Immunoglobulin domain MHC_I_3 PF16497.3 001309025.1_29723001_2 - 3.9e-05 23.1 0.0 5.5e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain C2-set_2 PF08205.10 001309025.1_29723001_2 - 0.0014 18.5 0.2 0.0036 17.2 0.2 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001309025.1_29723001_2 - 0.0024 17.9 0.0 0.0054 16.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain CYYR1 PF10873.6 001309025.1_29723001_2 - 0.038 14.3 0.5 0.068 13.5 0.5 1.3 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Podoplanin PF05808.9 001309025.1_29723001_2 - 0.1 12.6 1.2 0.23 11.5 1.2 1.5 1 0 0 1 1 1 0 Podoplanin MHC_II_beta PF00969.17 001308998.1_29722001_1 - 3.8e-37 126.1 1.1 5.9e-37 125.5 1.1 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001308998.1_29722001_1 - 3.4e-25 88.2 0.1 7.1e-25 87.2 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001308998.1_29722001_1 - 7.8e-06 26.3 0.1 2.5e-05 24.7 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001308998.1_29722001_1 - 0.00036 20.5 0.1 0.00062 19.8 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin domain DUF202 PF02656.13 001308998.1_29722001_1 - 0.056 13.8 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) I-set PF07679.14 001308998.1_29722001_1 - 0.12 12.4 0.0 0.35 10.8 0.0 1.8 1 1 0 1 1 1 0 Immunoglobulin I-set domain TLV_coat PF00429.17 001305391.1_31324001_1 - 2.4e-59 201.4 5.6 2.6e-56 191.3 1.6 2.2 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) TLV_coat PF00429.17 001305226.1_31324001_1 - 8.8e-62 209.4 9.1 1e-57 196.0 0.4 3.1 3 0 0 3 3 3 3 ENV polyprotein (coat polyprotein) Ysc84 PF04366.10 110343.1_32924120_2 - 3.9e-40 136.4 0.0 6e-40 135.8 0.0 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.26 110343.1_32924120_2 - 3.1e-15 55.4 0.0 6.3e-15 54.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 110343.1_32924120_2 - 1.4e-14 53.6 0.0 2.5e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 110343.1_32924120_2 - 1.2e-09 37.6 0.0 2.2e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Kdo PF06293.12 001007581.1_32924001_1 - 1.6e-10 40.6 0.0 2.3e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 001007581.1_32924001_1 - 2.8e-07 30.2 0.0 4.2e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.23 001007581.1_32924001_1 - 2.9e-07 30.0 0.0 4.2e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001007581.1_32924001_1 - 4.7e-05 22.7 0.0 6.9e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001007581.1_32924001_1 - 0.0002 21.2 2.9 0.39 10.5 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family EcKinase PF02958.18 001007581.1_32924001_1 - 0.15 11.2 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase ENOD40 PF08247.9 001007581.1_32924001_3 - 0.053 13.4 1.6 0.15 12.0 1.6 1.8 1 0 0 1 1 1 0 ENOD40 protein Glyco_transf_6 PF03414.11 132144.1_43524120_1 - 7.2e-61 205.6 5.2 9.4e-61 205.2 1.4 2.0 1 1 1 2 2 2 2 Glycosyltransferase family 6 Glyco_transf_6 PF03414.11 132144.1_43524120_3 - 5.4e-43 146.8 0.1 7e-43 146.5 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 6 Peptidase_C48 PF02902.17 001002834.1_45723001_1 - 2.6e-42 145.0 1.0 3.8e-42 144.4 1.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C57 PF03290.11 001002834.1_45723001_1 - 0.00038 19.2 0.0 0.19 10.3 0.0 2.1 1 1 1 2 2 2 2 Vaccinia virus I7 processing peptidase Sep15_SelM PF08806.9 001146700.1_39722001_1 - 2.3e-21 75.6 0.0 3.4e-21 75.1 0.0 1.2 1 0 0 1 1 1 1 Sep15/SelM redox domain DUF4148 PF13663.4 001146700.1_39722001_1 - 0.043 13.9 0.7 0.11 12.6 0.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) AIRS_C PF02769.20 001257996.1_09925001_2 - 2.8e-28 98.9 0.1 4.6e-28 98.2 0.1 1.3 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.22 001257996.1_09925001_2 - 1.4e-09 38.3 0.1 3.4e-09 37.1 0.1 1.6 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain Pyr_redox_2 PF07992.12 001256217.1_39726001_1 - 1.7e-53 181.6 0.1 2.2e-53 181.3 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 001256217.1_39726001_1 - 5.1e-28 97.4 0.0 9.2e-28 96.6 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 001256217.1_39726001_1 - 3.9e-17 62.5 1.9 8.4e-14 51.8 0.1 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Glutaredoxin PF00462.22 001256217.1_39726001_1 - 5.5e-15 55.2 2.0 5.9e-15 55.1 0.2 2.1 2 0 0 2 2 1 1 Glutaredoxin Pyr_redox_3 PF13738.4 001256217.1_39726001_1 - 1e-12 47.8 4.7 2.7e-10 39.8 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 001256217.1_39726001_1 - 3.7e-05 22.9 0.5 7.9e-05 21.8 0.5 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.22 001256217.1_39726001_1 - 0.00037 20.1 0.1 0.00068 19.2 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.19 001256217.1_39726001_1 - 0.00059 19.1 0.0 0.036 13.2 0.0 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.15 001256217.1_39726001_1 - 0.00094 18.3 0.9 0.0018 17.4 0.2 1.7 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.12 001256217.1_39726001_1 - 0.0014 17.3 1.4 0.0048 15.5 0.6 2.1 2 1 1 3 3 3 1 HI0933-like protein FAD_oxidored PF12831.5 001256217.1_39726001_1 - 0.004 16.4 0.4 0.0071 15.6 0.4 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.20 001256217.1_39726001_1 - 0.029 13.3 3.3 0.35 9.8 3.3 2.1 1 1 0 1 1 1 0 Glucose inhibited division protein A NAD_binding_7 PF13241.4 001256217.1_39726001_1 - 0.17 12.2 0.2 1.6 9.1 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_8 PF13450.4 001256217.1_39726001_1 - 0.52 10.5 5.0 0.15 12.2 0.3 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.17 001256217.1_39726001_1 - 2.3 7.3 4.4 1.1 8.4 0.2 2.1 2 0 0 2 2 2 0 FAD binding domain HATPase_c_3 PF13589.4 130940.1_26222120_1 - 4.6e-05 23.1 0.0 7.1e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.24 130940.1_26222120_1 - 0.032 14.6 0.1 0.069 13.6 0.0 1.5 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Kazal_1 PF00050.19 001172841.1_09922001_3 - 8.5e-16 57.6 6.0 1.2e-15 57.1 6.0 1.2 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 001172841.1_09922001_3 - 1.6e-10 40.9 4.1 2.9e-10 40.0 4.1 1.4 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Ig_3 PF13927.4 001172760.1_09924001_3 - 9.3e-17 61.3 0.6 2.8e-12 46.9 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001172760.1_09924001_3 - 2.3e-15 56.3 0.1 2.5e-12 46.6 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.15 001172760.1_09924001_3 - 8.6e-15 54.7 0.7 9.6e-07 28.8 0.0 3.2 2 1 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.23 001172760.1_09924001_3 - 1.4e-12 47.5 0.7 1.6e-11 44.0 0.2 2.3 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001172760.1_09924001_3 - 3.2e-10 40.1 1.0 2.6e-08 34.0 0.1 2.7 2 1 0 2 2 2 1 Immunoglobulin domain Receptor_2B4 PF11465.6 001172760.1_09924001_3 - 0.00029 20.9 0.1 0.0057 16.7 0.0 2.2 2 0 0 2 2 2 1 Natural killer cell receptor 2B4 Ig_4 PF16680.3 001172760.1_09924001_3 - 0.01 16.1 0.0 0.026 14.8 0.0 1.7 1 0 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 001172760.1_09924001_3 - 0.026 14.5 0.0 0.061 13.3 0.0 1.6 1 1 0 1 1 1 0 Izumo-like Immunoglobulin domain Ig_5 PF16681.3 001172760.1_09924001_3 - 0.04 14.2 0.0 0.083 13.2 0.0 1.4 1 0 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain OAD_gamma PF04277.11 001172760.1_09924001_3 - 0.76 10.3 6.1 5.3 7.6 6.1 2.2 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain FAP PF07174.9 001172760.1_09924001_3 - 0.88 8.8 13.9 1.4 8.2 13.9 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Trypan_PARP PF05887.9 001172760.1_09924001_3 - 5.1 7.0 20.1 9.1 6.2 20.1 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) 7tm_1 PF00001.19 001173396.1_09923001_1 - 2.4e-80 269.5 2.7 2.9e-80 269.2 2.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001173396.1_09923001_1 - 1.4e-16 60.5 0.0 2.2e-16 59.9 0.0 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001173396.1_09923001_1 - 1e-08 34.8 0.1 2.7e-08 33.4 0.1 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 001173396.1_09923001_1 - 4.8e-08 32.5 6.8 1.5e-07 30.9 6.7 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001173396.1_09923001_1 - 1.1e-06 28.5 9.3 1.2e-05 25.0 7.1 2.3 2 1 0 2 2 2 1 Olfactory receptor Git3 PF11710.6 001173396.1_09923001_1 - 0.75 9.4 10.4 1.2 8.7 10.4 1.3 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 DUF2070 PF09843.7 001173396.1_09923001_1 - 9.9 4.2 9.5 14 3.7 9.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) 7tm_1 PF00001.19 001172742.1_09923001_1 - 8e-37 126.8 14.2 4.9e-36 124.2 14.2 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-H2C2_2 PF13465.4 001012325.2_32926001_2 - 9.6e-127 408.2 138.7 4e-09 36.4 0.7 17.9 17 0 0 17 17 17 16 Zinc-finger double domain zf-C2H2 PF00096.24 001012325.2_32926001_2 - 3.8e-78 253.7 144.0 1.9e-06 27.9 1.6 17.2 17 0 0 17 17 16 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001012325.2_32926001_2 - 2.2e-46 152.4 152.8 0.00043 20.7 1.0 17.6 18 0 0 18 18 16 16 C2H2-type zinc finger KRAB PF01352.25 001012325.2_32926001_2 - 2.8e-20 71.6 0.1 4.9e-20 70.8 0.1 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 001012325.2_32926001_2 - 4.9e-18 64.8 95.2 0.014 15.4 4.2 11.6 4 2 10 14 14 14 14 Zinc ribbon domain zf-C2H2_6 PF13912.4 001012325.2_32926001_2 - 6.6e-18 64.1 108.3 0.039 13.8 0.5 16.8 16 0 0 16 16 16 11 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001012325.2_32926001_2 - 3.1e-15 55.5 81.5 0.0009 18.8 0.2 15.9 16 0 0 16 16 16 7 zinc-finger C2H2-type XPA_N PF01286.16 001012325.2_32926001_2 - 1.1e-10 41.2 85.7 0.92 9.5 1.6 16.6 16 0 0 16 16 16 7 XPA protein N-terminal zf-C2H2_jaz PF12171.6 001012325.2_32926001_2 - 5.8e-05 23.2 106.0 0.087 13.0 0.4 16.8 17 0 0 17 17 17 6 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 001012325.2_32926001_2 - 0.012 15.2 1.8 0.012 15.2 1.8 18.7 22 4 0 22 22 21 0 C2H2-type zinc-finger domain zf-met PF12874.5 001012325.2_32926001_2 - 0.039 14.2 0.5 0.039 14.2 0.5 17.1 18 0 0 18 18 17 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.4 001012325.2_32926001_2 - 0.05 13.4 0.4 0.05 13.4 0.4 12.6 13 0 0 13 13 13 0 zinc-finger of a C2HC-type zf-trcl PF13451.4 001012325.2_32926001_2 - 0.23 11.2 85.5 3.5 7.4 2.9 15.1 13 3 2 15 15 15 0 Probable zinc-ribbon domain zinc_ribbon_15 PF17032.3 001012325.2_32926001_2 - 0.23 12.1 89.5 0.29 11.8 2.6 9.5 3 2 8 11 11 10 0 zinc-ribbon family Desulfoferrod_N PF06397.10 001012325.2_32926001_2 - 0.33 10.5 75.8 2.6 7.6 0.3 15.3 16 0 0 16 16 16 0 Desulfoferrodoxin, N-terminal domain BolA PF01722.16 001012325.2_32926001_2 - 2.6 8.2 21.4 16 5.7 0.1 7.3 3 2 7 10 10 10 0 BolA-like protein ANXA2R PF15721.3 001302966.1_32924001_3 - 2.9e-62 210.5 10.9 4.3e-62 209.9 10.9 1.3 1 0 0 1 1 1 1 Annexin-2 receptor V1R PF03402.12 134192.3_32923001_2 - 1.3e-24 87.1 13.7 2.4e-24 86.3 13.7 1.3 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 134192.3_32923001_2 - 5.4e-09 35.5 20.8 8.4e-09 34.8 20.8 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 134192.3_32923001_2 - 4.9e-08 32.4 16.2 7.5e-08 31.8 16.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) RhoGAP PF00620.25 024494.1_26223120_1 - 2.9e-09 36.8 0.0 5e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain SLAC1 PF03595.15 024494.1_26223120_1 - 0.034 13.4 0.4 0.048 12.9 0.4 1.1 1 0 0 1 1 1 0 Voltage-dependent anion channel Pacs-1 PF10254.7 024494.1_26223120_2 - 0.093 11.5 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein RhoGAP PF00620.25 024494.1_26223120_3 - 1.1e-06 28.4 0.0 1.7e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain Methyltransf_32 PF13679.4 001131418.1_43529001_3 - 1e-30 106.7 4.0 2.5e-29 102.2 4.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001131418.1_43529001_3 - 0.0021 17.7 0.1 0.008 15.9 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 001131418.1_43529001_3 - 0.0065 17.0 0.0 0.018 15.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.11 001131418.1_43529001_3 - 0.012 15.0 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_11 PF08241.10 001131418.1_43529001_3 - 0.021 15.3 0.0 0.065 13.7 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Homeobox PF00046.27 001285576.1_09022001_1 - 2e-18 65.8 5.5 3.6e-18 65.0 5.5 1.4 1 0 0 1 1 1 1 Homeobox domain TFIIF_alpha PF05793.10 001285576.1_09022001_1 - 0.045 12.2 3.6 0.06 11.8 3.6 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Homez PF11569.6 001285576.1_09022001_1 - 0.98 8.8 7.8 0.082 12.3 0.6 2.6 3 0 0 3 3 3 0 Homeodomain leucine-zipper encoding, Homez GLTT PF01744.18 001285576.1_09022001_2 - 0.4 10.3 3.3 0.68 9.6 2.2 1.9 1 1 0 1 1 1 0 GLTT repeat (6 copies) 7tm_1 PF00001.19 001285655.1_09023001_3 - 1.2e-30 106.5 4.5 2.1e-30 105.7 4.5 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001285655.1_09023001_3 - 2.6e-07 30.2 3.4 3.4e-07 29.8 3.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 001285655.1_09023001_3 - 6.5e-06 25.6 1.2 9.8e-06 25.0 1.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.7 001285655.1_09023001_3 - 0.018 14.2 0.2 0.047 12.9 0.2 1.6 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srw TAS2R PF05296.11 001285655.1_09023001_3 - 0.11 11.5 7.2 0.19 10.6 7.2 1.4 1 1 0 1 1 1 0 Taste receptor protein (TAS2R) 7TM_GPCR_Srbc PF10316.7 001285655.1_09023001_3 - 0.12 11.7 3.6 0.31 10.4 3.6 1.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srx PF10328.7 001285655.1_09023001_3 - 0.13 11.5 4.6 0.12 11.5 3.4 1.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Flp_Fap PF04964.12 001285655.1_09023001_3 - 0.25 11.1 1.3 0.59 9.9 1.3 1.6 1 0 0 1 1 1 0 Flp/Fap pilin component Methyltransf_2 PF00891.16 001285598.1_09023001_1 - 4.6e-91 303.9 0.0 6.1e-91 303.5 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Dimerisation2 PF16864.3 001285598.1_09023001_1 - 3.6e-33 113.3 0.5 1e-32 111.8 0.2 1.9 2 0 0 2 2 2 1 Dimerisation domain Methyltransf_25 PF13649.4 001285598.1_09023001_1 - 2.3e-08 34.5 0.0 4.5e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001285598.1_09023001_1 - 1.8e-07 30.9 0.0 3.1e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001285598.1_09023001_1 - 3.4e-05 24.4 0.0 7.1e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001285598.1_09023001_1 - 0.00043 20.1 0.0 0.00069 19.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain 7tm_1 PF00001.19 001285591.1_09025001_3 - 1.3e-30 106.4 37.4 6e-30 104.2 37.4 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001285591.1_09025001_3 - 2.1e-10 40.7 22.1 9.1e-10 38.6 14.2 2.3 1 1 1 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001285591.1_09025001_3 - 1.5e-09 37.5 30.2 2.6e-09 36.7 30.2 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Interferon PF00143.17 001166318.1_49822001_1 - 2.7e-64 216.0 0.5 3.1e-64 215.8 0.5 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain F-box-like PF12937.5 001258439.1_49827001_1 - 5.3e-05 22.9 0.1 0.00012 21.8 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001258439.1_49827001_1 - 0.0023 17.7 0.1 0.0058 16.3 0.1 1.6 1 0 0 1 1 1 1 F-box domain BTK PF00779.17 001258439.1_49827001_1 - 0.0045 16.6 1.3 0.018 14.7 1.3 2.0 1 0 0 1 1 1 1 BTK motif Interferon PF00143.17 001164855.1_49822001_1 - 7.7e-66 221.1 0.3 9.3e-66 220.8 0.3 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Snf7 PF03357.19 001190190.1_49823001_3 - 2.6e-52 176.7 19.7 4e-52 176.2 19.7 1.2 1 0 0 1 1 1 1 Snf7 SYF2 PF08231.10 001190190.1_49823001_3 - 0.083 13.2 8.0 0.17 12.1 8.0 1.5 1 1 0 1 1 1 0 SYF2 splicing factor DUF155 PF02582.12 001190190.1_49823001_3 - 0.11 12.4 1.0 0.17 11.8 1.0 1.2 1 0 0 1 1 1 0 Uncharacterised ACR, YagE family COG1723 Interferon PF00143.17 001164860.1_49822001_1 - 8.2e-64 214.5 0.1 9.3e-64 214.3 0.1 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain p450 PF00067.20 214422.1_49824001_3 - 3e-130 434.9 0.4 3.5e-130 434.7 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 Proteasome PF00227.24 001144901.1_49822001_2 - 6.2e-56 188.8 0.1 7.8e-56 188.4 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 001144901.1_49822001_2 - 9.6e-14 50.6 0.0 1.6e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Interferon PF00143.17 001130230.1_49822001_1 - 2.9e-65 219.2 0.3 3.3e-65 219.0 0.3 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain TBCC PF07986.10 001258407.1_49823001_3 - 1.1e-42 144.5 0.0 1.7e-42 143.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.3 001258407.1_49823001_3 - 6.2e-27 94.2 11.5 1e-26 93.5 11.5 1.4 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain DDE_Tnp_1_6 PF13751.4 001258407.1_49823001_3 - 0.03 14.4 5.8 0.038 14.1 0.8 2.3 2 0 0 2 2 2 0 Transposase DDE domain 7tm_1 PF00001.19 001167628.1_49823001_1 - 4.2e-57 193.3 15.4 5.2e-57 193.0 15.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001167628.1_49823001_1 - 1.6e-12 47.3 6.6 1.9e-12 47.0 6.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001167628.1_49823001_1 - 4.3e-06 26.1 5.7 5.9e-06 25.7 5.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.7 001167628.1_49823001_1 - 7.6e-05 22.1 2.7 7.6e-05 22.1 2.7 2.0 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001167628.1_49823001_1 - 0.0087 15.7 4.4 0.0087 15.7 4.4 2.0 2 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srw PF10324.7 001167628.1_49823001_1 - 0.017 14.3 0.0 0.017 14.3 0.0 2.1 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srw Rab5ip PF07019.10 001167628.1_49823001_1 - 0.039 14.4 1.3 0.11 13.0 0.1 2.3 2 0 0 2 2 2 0 Rab5-interacting protein (Rab5ip) Serpentine_r_xa PF03383.13 001167628.1_49823001_1 - 0.051 13.4 0.5 0.051 13.4 0.5 2.2 2 1 0 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa TAS2R PF05296.11 001167628.1_49823001_1 - 0.054 12.5 5.2 0.3 10.0 5.2 1.9 1 1 0 1 1 1 0 Taste receptor protein (TAS2R) GNT-I PF03071.13 001078668.1_49825001_3 - 6e-203 674.3 0.0 7.1e-203 674.0 0.0 1.0 1 0 0 1 1 1 1 GNT-I family Glyco_tranf_2_3 PF13641.4 001078668.1_49825001_3 - 0.0018 18.1 0.1 0.0095 15.7 0.1 2.1 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Pkinase PF00069.23 001185048.1_39729001_2 - 1.7e-54 184.8 0.0 2.5e-54 184.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001185048.1_39729001_2 - 1.9e-42 145.3 0.1 2.7e-42 144.7 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.6 001185048.1_39729001_2 - 2.2e-18 65.7 5.5 4.3e-17 61.6 1.3 2.6 2 0 0 2 2 2 2 Oxidative-stress-responsive kinase 1 C terminal zf-RING_UBOX PF13445.4 001205176.1_39727001_2 - 1e-11 44.5 3.2 1e-11 44.5 3.2 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001205176.1_39727001_2 - 2.6e-11 43.3 8.3 1e-10 41.5 8.3 2.1 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING SPRY PF00622.26 001205176.1_39727001_2 - 3.9e-10 39.8 0.2 9.4e-10 38.5 0.2 1.6 1 0 0 1 1 1 1 SPRY domain zf-C3HC4 PF00097.23 001205176.1_39727001_2 - 4e-09 36.1 6.5 1.3e-08 34.5 6.5 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001205176.1_39727001_2 - 7.7e-09 35.4 2.1 7.7e-09 35.4 2.1 3.3 3 0 0 3 3 3 1 B-box zinc finger zf-C3HC4_2 PF13923.4 001205176.1_39727001_2 - 3e-08 33.2 6.7 2.6e-07 30.3 7.4 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001205176.1_39727001_2 - 7.8e-07 29.1 7.1 3e-06 27.3 7.1 2.1 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.4 001205176.1_39727001_2 - 1.7e-06 27.7 5.7 1.7e-06 27.7 5.7 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 001205176.1_39727001_2 - 8.4e-06 25.4 4.9 8.4e-06 25.4 4.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) PRY PF13765.4 001205176.1_39727001_2 - 5.2e-05 22.6 0.1 0.00011 21.6 0.1 1.6 1 0 0 1 1 1 1 SPRY-associated domain FAM76 PF16046.3 001205176.1_39727001_2 - 0.00021 20.6 7.4 0.00035 19.9 7.4 1.2 1 0 0 1 1 1 1 FAM76 protein zf-RING_10 PF16685.3 001205176.1_39727001_2 - 0.0086 16.1 2.7 0.033 14.2 2.7 2.1 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-Nse PF11789.6 001205176.1_39727001_2 - 0.025 14.3 4.0 0.067 12.9 4.0 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Fib_alpha PF08702.8 001205176.1_39727001_2 - 0.061 13.4 10.0 0.11 12.6 10.0 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family zf-UDP PF14569.4 001205176.1_39727001_2 - 0.093 12.7 0.7 0.26 11.3 0.7 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-RING_6 PF14835.4 001205176.1_39727001_2 - 0.097 12.4 8.2 0.09 12.5 2.3 3.0 3 0 0 3 3 3 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 001205176.1_39727001_2 - 0.85 9.4 13.1 0.33 10.7 9.0 2.5 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 OmpH PF03938.12 001205176.1_39727001_2 - 4.3 7.2 14.3 6.9 6.5 14.3 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Exonuc_VII_L PF02601.13 001205176.1_39727001_2 - 7.4 5.9 6.0 11 5.3 6.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Pkinase_Tyr PF07714.15 001204807.1_37927001_3 - 9.3e-58 195.4 0.0 2.2e-57 194.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Ank_2 PF12796.5 001204807.1_37927001_3 - 1.1e-55 186.0 7.4 1.4e-13 51.1 0.8 6.3 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001204807.1_37927001_3 - 3.4e-48 161.3 27.9 8.4e-11 42.1 0.2 8.7 3 3 7 10 10 10 9 Ankyrin repeats (many copies) Ank PF00023.28 001204807.1_37927001_3 - 2.1e-47 157.4 28.9 8.7e-07 29.0 0.0 11.2 12 0 0 12 12 11 8 Ankyrin repeat Pkinase PF00069.23 001204807.1_37927001_3 - 2.3e-46 158.2 0.0 5.6e-46 156.9 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Ank_3 PF13606.4 001204807.1_37927001_3 - 5e-40 130.8 15.6 0.0003 20.8 0.0 11.4 11 0 0 11 11 11 8 Ankyrin repeat Ank_5 PF13857.4 001204807.1_37927001_3 - 7.8e-38 127.8 9.3 9e-09 35.3 0.1 8.9 2 1 6 9 9 9 7 Ankyrin repeats (many copies) APH PF01636.21 001204807.1_37927001_3 - 0.052 13.3 0.0 0.087 12.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.12 001204807.1_37927001_3 - 0.064 12.5 0.1 0.11 11.7 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 001204807.1_37927001_3 - 0.077 12.5 1.5 0.16 11.4 0.1 2.0 2 0 0 2 2 2 0 RIO1 family Kinase-like PF14531.4 001204807.1_37927001_3 - 0.18 11.0 0.0 0.31 10.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Rdx PF10262.7 001243847.1_39722001_1 - 1.3e-17 63.6 0.0 1.8e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 Rdx family DUF2053 PF09767.7 001194024.1_29622001_2 - 1.2e-66 223.7 5.6 1.2e-66 223.7 5.6 1.7 2 0 0 2 2 2 1 Predicted membrane protein (DUF2053) 7tm_1 PF00001.19 001251818.1_49823001_1 - 2e-30 105.8 22.3 2.6e-30 105.4 22.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001251818.1_49823001_1 - 3e-06 26.7 14.2 3e-06 26.7 14.2 2.1 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001251818.1_49823001_1 - 0.00013 21.7 20.9 0.00073 19.2 20.9 2.4 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001251818.1_49823001_1 - 0.89 8.7 23.6 0.082 12.1 16.4 2.3 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx zf-ISL3 PF14690.4 001251818.1_49823001_3 - 5 7.7 11.0 0.68 10.5 1.8 2.9 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 PMP22_Claudin PF00822.18 001265844.1_29624001_3 - 2.4e-22 79.4 0.4 3.4e-22 79.0 0.4 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001265844.1_29624001_3 - 1.8e-05 24.5 4.1 0.00019 21.1 4.1 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction 7tm_1 PF00001.19 001260786.1_29624001_1 - 1.8e-13 50.2 0.0 2.6e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Protamine_P2 PF00841.17 001281541.1_31321001_1 - 1.9e-32 111.5 44.7 1.9e-32 111.5 44.7 2.0 1 1 1 2 2 2 1 Sperm histone P2 SH2 PF00017.22 001170518.2_49825001_3 - 6.9e-12 45.1 0.0 1.9e-11 43.7 0.0 1.7 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.14 001170518.2_49825001_3 - 6e-11 42.4 1.2 6e-11 42.4 1.2 2.2 2 0 0 2 2 2 1 SOCS box Kinesin PF00225.21 001204891.1_39729001_1 - 1e-115 386.1 0.6 1.6e-115 385.5 0.6 1.3 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.3 001204891.1_39729001_1 - 1.4e-76 256.5 14.8 2e-63 213.7 0.4 3.6 3 1 1 4 4 4 2 Kinesin-associated Microtub_bd PF16796.3 001204891.1_39729001_1 - 5.5e-24 84.7 0.2 1.1e-23 83.7 0.2 1.5 1 0 0 1 1 1 1 Microtubule binding FHA PF00498.24 001204891.1_39729001_1 - 8.6e-08 32.3 0.3 3.1e-07 30.5 0.1 2.1 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.3 001204891.1_39729001_1 - 0.0011 19.1 0.0 0.0024 18.0 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain SAP PF02037.25 001204891.1_39729001_1 - 8 6.2 7.7 2.8 7.7 0.4 3.4 3 0 0 3 3 3 0 SAP domain ADH_zinc_N PF00107.24 001260627.1_29623001_3 - 1.5e-27 95.9 0.1 2.6e-27 95.1 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001260627.1_29623001_3 - 4.6e-25 87.5 0.9 1.2e-24 86.1 0.9 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.3 001260627.1_29623001_3 - 0.00017 21.0 0.0 0.00027 20.3 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.4 001260627.1_29623001_3 - 0.00022 22.1 0.0 0.00046 21.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.12 001260627.1_29623001_3 - 0.0043 16.5 0.1 0.0078 15.7 0.1 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DSPc PF00782.18 001265675.1_29622001_1 - 2.4e-31 108.2 0.0 2.9e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 001265675.1_29622001_1 - 0.0067 15.9 0.0 0.0086 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CCDC85 PF10226.7 001261659.2_29622001_2 - 5e-78 261.1 0.4 6e-78 260.8 0.4 1.0 1 0 0 1 1 1 1 CCDC85 family TSC22 PF01166.16 001261659.2_29622001_2 - 0.0015 18.6 7.3 0.46 10.7 0.9 2.8 2 1 1 3 3 3 2 TSC-22/dip/bun family AMH_N PF04709.10 001261659.2_29622001_2 - 0.098 11.5 4.1 0.13 11.0 4.1 1.3 1 0 0 1 1 1 0 Anti-Mullerian hormone, N terminal region DUF972 PF06156.11 001261659.2_29622001_2 - 0.16 12.5 2.6 0.87 10.1 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Lebercilin PF15619.4 001261659.2_29622001_2 - 4.5 6.7 16.0 2.8 7.4 8.4 2.1 1 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease GIT_CC PF16559.3 001261659.2_29622001_2 - 7.8 6.5 6.4 1.4 8.9 1.8 1.9 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor 7tm_1 PF00001.19 001257223.1_08023001_1 - 3.7e-50 170.5 12.2 4.7e-50 170.2 12.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001257223.1_08023001_1 - 1.6e-11 44.0 7.3 4e-11 42.6 7.3 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.7 001257223.1_08023001_1 - 1.5e-07 30.9 4.2 1.5e-07 30.9 4.2 1.5 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 001257223.1_08023001_1 - 4.3e-07 29.4 12.0 6.2e-07 28.9 12.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001257223.1_08023001_1 - 3.7e-05 23.5 9.3 0.00012 21.8 1.5 2.4 3 0 0 3 3 3 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001257223.1_08023001_1 - 0.00023 20.4 6.7 0.00023 20.4 6.7 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Thioredoxin PF00085.18 001194267.1_29622001_1 - 3.8e-10 39.5 0.0 7.6e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin DUF342 PF03961.11 001194267.1_29622001_1 - 0.52 8.7 3.3 0.66 8.4 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Brix PF04427.16 001204460.1_37624001_1 - 1.3e-44 152.5 0.5 1.8e-44 152.0 0.5 1.2 1 0 0 1 1 1 1 Brix domain DOR PF14839.4 001204460.1_37624001_1 - 0.11 12.3 5.5 0.23 11.2 5.5 1.5 1 0 0 1 1 1 0 DOR family Prothymosin PF03247.12 001204460.1_37624001_1 - 3.6 8.0 12.8 6.7 7.1 12.8 1.4 1 0 0 1 1 1 0 Prothymosin/parathymosin family BTB PF00651.29 001261685.2_29624001_3 - 4.7e-18 65.3 0.1 1.2e-17 64.0 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 001261685.2_29624001_3 - 8.6e-18 63.6 36.7 1.5e-05 25.1 2.6 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001261685.2_29624001_3 - 4.9e-15 55.1 22.4 3.9e-07 30.1 0.7 5.3 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 001261685.2_29624001_3 - 8.6e-13 47.8 34.0 0.0002 21.8 2.6 4.9 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_5 PF13909.4 001261685.2_29624001_3 - 0.00054 19.5 21.4 0.0036 16.9 2.4 4.1 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.3 001261685.2_29624001_3 - 0.00093 18.8 23.9 0.0066 16.1 2.3 4.4 4 0 0 4 4 4 3 zinc-finger C2H2-type zf-C2H2_2 PF12756.5 001261685.2_29624001_3 - 0.0091 16.2 22.5 0.38 11.0 0.7 4.6 1 1 3 4 4 4 3 C2H2 type zinc-finger (2 copies) DUF899 PF05988.10 001261685.2_29624001_3 - 0.0096 15.3 0.1 0.0096 15.3 0.1 1.8 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF899) zf-CHCC PF10276.7 001261685.2_29624001_3 - 0.024 14.6 0.6 0.25 11.3 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger domain zf-met PF12874.5 001261685.2_29624001_3 - 0.031 14.5 24.5 0.032 14.5 1.6 4.4 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 001261685.2_29624001_3 - 0.094 12.6 24.7 0.57 10.1 1.0 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001261685.2_29624001_3 - 0.8 10.0 19.1 4.3 7.6 0.1 4.5 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.13 001261685.2_29624001_3 - 0.83 9.5 3.5 10 6.0 0.0 3.1 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain AHH PF14412.4 001261685.2_29624001_3 - 1.3 9.0 6.5 1.3e+02 2.5 6.5 2.8 1 1 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH GAGA PF09237.9 001261685.2_29624001_3 - 1.4 8.6 8.5 35 4.2 0.1 4.1 1 1 3 4 4 4 0 GAGA factor zf-Dof PF02701.13 001261685.2_29624001_3 - 2.8 8.0 7.6 0.13 12.3 0.9 2.1 1 1 1 2 2 2 0 Dof domain, zinc finger FYVE PF01363.19 001261685.2_29624001_3 - 5.1 7.2 20.2 11 6.1 11.5 3.2 1 1 1 2 2 2 0 FYVE zinc finger zf-LYAR PF08790.9 001261685.2_29624001_3 - 7.6 6.4 10.6 2.2 8.1 0.2 3.5 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger SNAP PF14938.4 001258101.1_29624001_3 - 1.7e-26 93.2 11.6 2.4e-26 92.7 11.6 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP AP_endonuc_2 PF01261.22 001258101.1_29624001_3 - 0.066 12.5 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel TPR_10 PF13374.4 001258101.1_29624001_3 - 0.08 12.7 4.2 10 6.0 0.0 3.8 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.4 001258101.1_29624001_3 - 0.25 11.5 13.2 1.2 9.4 3.2 3.7 3 1 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.26 001258101.1_29624001_3 - 0.43 10.4 6.1 25 4.8 0.1 4.7 4 1 1 5 5 5 0 Tetratricopeptide repeat NSF PF02071.18 001258101.1_29624001_3 - 0.47 11.3 16.2 2.7 9.0 0.5 6.1 6 0 0 6 6 6 0 Aromatic-di-Alanine (AdAR) repeat TPR_14 PF13428.4 001258101.1_29624001_3 - 0.93 10.3 9.8 67 4.6 0.2 5.0 2 1 4 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.4 001258101.1_29624001_3 - 2 8.8 11.9 3.5 8.1 1.2 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.4 001258101.1_29624001_3 - 3.2 8.1 7.6 16 5.9 0.2 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat Lactamase_B PF00753.25 001193835.1_29629001_3 - 4.7e-19 69.0 0.9 7.5e-19 68.4 0.9 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily TruB_C PF09142.9 001193835.1_29629001_3 - 0.02 14.5 3.2 0.48 10.1 0.3 2.4 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal Lactamase_B_2 PF12706.5 001193835.1_29629001_3 - 0.1 11.9 0.1 0.17 11.3 0.1 1.3 1 0 0 1 1 1 0 Beta-lactamase superfamily domain DUF1681 PF07933.12 001194593.1_29626001_1 - 1.5e-55 186.8 0.0 2e-55 186.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) SURF6 PF04935.10 001194177.1_29623001_1 - 2.9e-44 151.1 46.7 2.9e-44 151.1 46.7 2.1 2 0 0 2 2 2 2 Surfeit locus protein 6 HLH PF00010.24 001308570.1_39523001_2 - 9.9e-11 41.3 2.1 1.2e-09 37.9 2.7 2.2 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Myc-LZ PF02344.13 001308570.1_39523001_2 - 0.00034 20.5 8.7 0.00034 20.5 8.7 2.5 2 0 0 2 2 2 1 Myc leucine zipper domain Striatin PF08232.10 001308570.1_39523001_2 - 0.042 14.3 3.6 0.16 12.5 1.0 2.1 2 0 0 2 2 2 0 Striatin family MHC_I PF00129.16 001309010.1_29723001_1 - 1.3e-93 311.4 2.5 1.8e-93 310.9 2.5 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001309010.1_29723001_1 - 3.2e-17 62.6 0.0 7.8e-17 61.4 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001309010.1_29723001_1 - 1.8e-16 59.6 7.6 3e-16 58.9 7.6 1.4 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001309010.1_29723001_1 - 5.7e-06 26.7 1.0 0.041 14.4 0.0 3.0 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001309010.1_29723001_1 - 0.00076 19.4 0.7 0.0014 18.5 0.1 1.7 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001309010.1_29723001_1 - 0.0026 17.7 0.1 0.0076 16.3 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin domain Methyltransf_2 PF00891.16 001306120.1_39523001_2 - 6.5e-88 293.6 0.0 8.5e-88 293.2 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Dimerisation2 PF16864.3 001306120.1_39523001_2 - 7.9e-33 112.2 1.4 1.1e-32 111.7 0.2 1.9 2 0 0 2 2 2 1 Dimerisation domain Methyltransf_25 PF13649.4 001306120.1_39523001_2 - 7.2e-07 29.7 0.0 1.6e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001306120.1_39523001_2 - 3.7e-05 23.4 0.0 6.3e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001306120.1_39523001_2 - 0.00059 20.4 0.0 0.0012 19.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MHC_II_alpha PF00993.18 001305928.1_29722001_1 - 2.4e-33 113.5 0.1 3.4e-33 113.1 0.1 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001305928.1_29722001_1 - 1.2e-28 98.1 0.5 2.6e-28 97.1 0.5 1.6 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001305928.1_29722001_1 - 5.1e-25 87.6 0.0 8.7e-25 86.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Marek_A PF02124.13 001305928.1_29722001_1 - 0.00016 21.4 0.0 0.00022 21.0 0.0 1.1 1 0 0 1 1 1 1 Marek's disease glycoprotein A Ig_3 PF13927.4 001305928.1_29722001_1 - 0.00019 21.8 0.0 0.00032 21.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 001305928.1_29722001_1 - 0.00088 19.2 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 001305928.1_29722001_1 - 0.069 13.4 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain SKG6 PF08693.8 001305928.1_29722001_1 - 0.11 11.8 1.7 0.25 10.6 1.7 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain TPR_17 PF13431.4 003667.3_26222120_1 - 0.02 15.1 0.2 1.7 9.1 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.4 003667.3_26222120_1 - 0.15 12.5 0.1 3.3 8.2 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 003667.3_26222120_1 - 0.25 11.1 2.8 1.4 8.7 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat HSP70 PF00012.18 001314206.1_09024001_1 - 2.7e-251 834.9 3.7 3e-251 834.7 3.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 001314206.1_09024001_1 - 6.5e-15 54.6 0.1 7e-13 48.0 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.4 001314206.1_09024001_1 - 0.0035 17.6 2.2 6.6 7.1 0.0 3.5 3 1 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.14 001314206.1_09024001_1 - 0.0055 16.3 0.0 0.012 15.2 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.16 001314206.1_09024001_1 - 0.064 12.4 1.7 0.57 9.2 0.2 2.9 2 1 0 2 2 2 0 Hydantoinase/oxoprolinase Radial_spoke_3 PF06098.9 001314206.1_09024001_1 - 0.94 8.6 8.2 0.24 10.5 3.3 2.0 2 0 0 2 2 2 0 Radial spoke protein 3 Ldh_1_N PF00056.21 001315678.1_49823001_1 - 1.2e-46 158.2 0.1 1.6e-46 157.8 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 001315678.1_49823001_1 - 3.9e-22 78.8 0.0 6e-22 78.2 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.14 001315678.1_49823001_1 - 0.0021 17.5 1.4 1.1 8.6 0.1 2.2 1 1 1 2 2 2 2 Family 4 glycosyl hydrolase UDPG_MGDP_dh_N PF03721.12 001315678.1_49823001_1 - 0.017 14.6 0.1 0.031 13.7 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain CLCA PF08434.9 126537.1_32922120_2 - 9.6e-63 212.1 0.1 1.2e-62 211.8 0.1 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel MCM_bind PF09739.7 001243591.1_49828001_2 - 1.7e-234 779.5 0.0 2e-234 779.2 0.0 1.0 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor Ribosomal_L6 PF00347.21 001243481.1_49824001_1 - 4.3e-32 110.5 1.4 5.8e-15 55.6 0.3 2.3 2 0 0 2 2 2 2 Ribosomal protein L6 TMEM126 PF07114.9 001243600.1_49823001_3 - 5e-74 247.5 0.6 6.1e-74 247.2 0.6 1.1 1 0 0 1 1 1 1 Transmembrane protein 126 Pkinase PF00069.23 001144113.1_49825001_2 - 6.3e-41 140.4 4.1 1.5e-21 76.8 0.1 2.6 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.15 001144113.1_49825001_2 - 1.9e-13 50.2 0.0 1.9e-09 37.1 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase NARP1 PF12569.6 001144113.1_49825001_2 - 0.63 8.7 15.3 3.6 6.2 0.0 2.2 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Peptidase_M54 PF07998.9 001243604.1_49823001_2 - 3.9e-15 56.2 0.7 1.2e-13 51.3 0.3 2.1 1 1 1 2 2 2 1 Peptidase family M54 Peptidase_M10 PF00413.22 001243604.1_49823001_2 - 0.0011 18.8 0.0 0.0027 17.4 0.0 1.7 1 1 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.4 001243604.1_49823001_2 - 0.0032 17.9 0.0 0.0051 17.2 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 001243604.1_49823001_2 - 0.0092 16.0 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M43 PF05572.11 001243604.1_49823001_2 - 0.014 15.2 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A Peptidase_M57 PF12388.6 001243604.1_49823001_2 - 0.029 13.8 0.1 0.052 13.0 0.1 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Zincin_1 PF06262.9 001243604.1_49823001_2 - 0.089 12.8 0.0 1.9 8.5 0.0 2.2 2 0 0 2 2 2 0 Zinicin-like metallopeptidase Reprolysin_4 PF13583.4 001243604.1_49823001_2 - 0.1 12.1 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 001243604.1_49823001_2 - 0.15 11.8 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Sec7 PF01369.18 001144120.1_49823001_1 - 5.4e-66 221.7 0.0 7.2e-66 221.3 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.27 001144120.1_49823001_1 - 4.4e-28 97.7 0.0 8.7e-28 96.8 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 001144120.1_49823001_1 - 1.6e-05 25.2 0.3 6.2e-05 23.2 0.3 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.4 001144120.1_49823001_1 - 0.011 15.7 0.1 0.052 13.5 0.1 2.0 1 1 0 1 1 1 0 PH domain PH_8 PF15409.4 001144120.1_49823001_1 - 0.02 15.0 0.0 0.16 12.2 0.0 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain SASRP1 PF15160.4 001144120.1_49823001_1 - 0.084 12.3 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated serine-rich protein 1 NUDE_C PF04880.11 001144120.1_49823001_1 - 0.38 11.1 4.9 0.65 10.3 4.9 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Hydrolase_like PF13242.4 001243608.1_49824001_1 - 6.2e-18 64.5 0.1 1.1e-17 63.7 0.1 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.4 001243608.1_49824001_1 - 5.1e-14 52.1 0.0 1.8e-13 50.4 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.24 001243608.1_49824001_1 - 9.3e-09 35.7 0.0 1.6e-07 31.7 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.4 001243608.1_49824001_1 - 9.5e-07 28.9 0.0 2.1e-06 27.8 0.0 1.5 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase ACC_central PF08326.10 001206399.1_49829001_1 - 2.3e-284 944.9 4.5 2.8e-284 944.7 4.5 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.20 001206399.1_49829001_1 - 8.9e-180 598.4 0.0 1.2e-179 598.0 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.15 001206399.1_49829001_1 - 2e-50 171.1 0.0 3.5e-50 170.3 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.20 001206399.1_49829001_1 - 2e-31 108.6 0.0 4.6e-31 107.5 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.17 001206399.1_49829001_1 - 4.3e-23 81.3 0.0 1.5e-22 79.6 0.0 2.0 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.20 001206399.1_49829001_1 - 8.8e-15 54.2 0.1 2.2e-14 52.9 0.1 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.4 001206399.1_49829001_1 - 0.00018 20.2 0.0 0.41 9.2 0.0 2.8 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.20 001206399.1_49829001_1 - 0.00036 20.0 0.0 0.0007 19.1 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.12 001206399.1_49829001_1 - 0.0066 16.4 0.0 0.022 14.7 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.11 001206399.1_49829001_1 - 0.048 13.1 0.0 0.15 11.4 0.0 1.8 2 0 0 2 2 2 0 D-ala D-ala ligase C-terminus zf-CSL PF05207.11 001243616.1_49826001_1 - 3e-22 78.0 3.8 5.7e-22 77.1 3.8 1.5 1 0 0 1 1 1 1 CSL zinc finger zf-RING_4 PF14570.4 001243616.1_49826001_1 - 0.25 10.9 5.5 0.28 10.8 3.3 2.2 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Glyco_transf_29 PF00777.16 213759.1_49823001_2 - 1.4e-69 234.4 0.0 1.7e-69 234.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) CGI-121 PF08617.8 001144846.1_49822001_1 - 5.8e-43 146.7 0.3 6.9e-43 146.4 0.3 1.1 1 0 0 1 1 1 1 Kinase binding protein CGI-121 DUF1464 PF07318.10 001144846.1_49822001_1 - 0.025 13.6 0.1 0.034 13.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) MHC_I PF00129.16 213768.1_49823001_1 - 6.9e-80 266.7 0.3 9.7e-80 266.2 0.3 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 213768.1_49823001_1 - 3.2e-18 65.9 0.1 6.4e-18 64.9 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain ig PF00047.23 213768.1_49823001_1 - 0.00026 21.0 0.1 0.00053 20.0 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 213768.1_49823001_1 - 0.00056 20.3 1.0 0.0043 17.5 0.5 2.4 1 1 1 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 213768.1_49823001_1 - 0.002 18.0 0.4 0.0046 16.9 0.4 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 213768.1_49823001_1 - 0.015 15.5 0.2 0.042 14.1 0.1 1.9 2 0 0 2 2 2 0 Immunoglobulin domain PepSY_TM PF03929.14 213768.1_49823001_1 - 0.054 12.7 0.6 0.11 11.7 0.6 1.8 1 1 0 1 1 1 0 PepSY-associated TM region EphA2_TM PF14575.4 213768.1_49823001_1 - 0.16 12.7 0.1 0.45 11.2 0.1 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Robl_LC7 PF03259.15 001243627.1_49822001_2 - 6.8e-18 64.1 0.1 1e-17 63.6 0.1 1.3 1 0 0 1 1 1 1 Roadblock/LC7 domain Peptidase_S10 PF00450.20 001243629.1_49824001_1 - 1.9e-138 462.2 0.2 2.3e-138 462.0 0.2 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Glyco_hydro_59 PF02057.13 001243631.1_49826001_2 - 0 1460.1 12.1 0 1459.9 12.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 DUF1080 PF06439.9 001243631.1_49826001_2 - 0.11 12.5 0.2 0.18 11.8 0.2 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) MAPEG PF01124.16 001044556.1_49821001_1 - 2.6e-24 85.4 0.3 3.4e-24 85.1 0.3 1.1 1 0 0 1 1 1 1 MAPEG family zf-H2C2_2 PF13465.4 001243641.1_49825001_2 - 1.5e-53 176.8 64.2 9.9e-08 32.0 1.3 9.6 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.24 001243641.1_49825001_2 - 1.3e-43 144.9 76.8 2.2e-06 27.7 1.3 8.5 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001243641.1_49825001_2 - 1.1e-19 69.3 71.2 0.00044 20.7 2.1 8.5 8 0 0 8 8 8 7 C2H2-type zinc finger KRAB PF01352.25 001243641.1_49825001_2 - 7.2e-13 47.9 0.1 1.3e-12 47.1 0.1 1.3 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 001243641.1_49825001_2 - 2.2e-09 37.1 30.6 0.013 15.5 1.2 5.6 3 2 1 5 5 5 4 Zinc ribbon domain zf-C2H2_6 PF13912.4 001243641.1_49825001_2 - 1.8e-08 34.0 51.2 0.016 15.0 0.3 8.8 8 0 0 8 8 8 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001243641.1_49825001_2 - 3.5e-07 30.2 33.3 0.12 12.6 0.0 8.2 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 001243641.1_49825001_2 - 0.0063 16.6 38.6 0.0089 16.2 2.4 5.1 3 1 2 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 001243641.1_49825001_2 - 0.027 14.7 1.2 0.027 14.7 1.2 8.2 8 0 0 8 8 8 0 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.3 001243641.1_49825001_2 - 0.074 13.7 22.8 3.9 8.2 0.9 4.3 1 1 3 4 4 4 0 zinc-ribbon family DUF3268 PF11672.6 001243641.1_49825001_2 - 0.13 12.4 22.5 0.38 11.0 1.0 4.4 2 2 0 4 4 4 0 zinc-finger-containing domain C1_4 PF07975.10 001243641.1_49825001_2 - 0.25 11.5 30.6 0.97 9.6 1.6 5.3 2 1 4 6 6 6 0 TFIIH C1-like domain HypA PF01155.17 001243641.1_49825001_2 - 1.7 8.6 22.2 4.1 7.3 0.3 4.2 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-LYAR PF08790.9 001243641.1_49825001_2 - 4.6 7.1 35.7 0.31 10.9 0.9 7.3 8 0 0 8 8 8 0 LYAR-type C2HC zinc finger CpXC PF14353.4 001243641.1_49825001_2 - 6.2 6.7 27.8 4.7 7.1 0.1 7.0 3 2 4 7 7 7 0 CpXC protein GAGA PF09237.9 001243641.1_49825001_2 - 9.3 6.0 15.2 8.4 6.2 0.6 4.2 3 1 1 4 4 4 0 GAGA factor Got1 PF04178.10 001243648.1_49822001_1 - 9.1e-35 119.4 15.4 1.4e-34 118.8 14.8 1.5 1 1 1 2 2 2 2 Got1/Sft2-like family Proteasome PF00227.24 001243652.1_49823001_3 - 3.3e-62 209.2 0.2 4.5e-62 208.8 0.2 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 001243652.1_49823001_3 - 2e-14 52.8 0.5 4.6e-14 51.6 0.2 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Mito_carr PF00153.25 001244166.1_49824001_1 - 8.5e-15 54.3 0.3 1.3e-07 31.3 0.0 2.9 3 0 0 3 3 3 2 Mitochondrial carrier protein Mito_carr PF00153.25 001244167.1_49824001_1 - 7.8e-15 54.4 0.3 1.2e-07 31.4 0.0 2.9 3 0 0 3 3 3 2 Mitochondrial carrier protein Dickkopf_N PF04706.10 001145384.1_49822001_1 - 3.1e-18 65.9 36.2 6.5e-17 61.6 17.3 3.0 2 1 1 3 3 3 2 Dickkopf N-terminal cysteine-rich region Trypsin PF00089.24 001044592.1_49824001_2 - 8.7e-69 231.6 0.0 1.2e-68 231.1 0.0 1.2 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 001044592.1_49824001_2 - 1.9e-20 72.7 9.9 1.9e-20 72.7 9.9 2.6 3 1 1 4 4 3 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain EGF PF00008.25 001044592.1_49824001_2 - 1.7e-09 37.6 19.8 1.1e-07 31.8 9.2 3.4 2 0 0 2 2 2 2 EGF-like domain FXa_inhibition PF14670.4 001044592.1_49824001_2 - 5.8e-09 36.0 8.9 5.8e-09 36.0 8.9 3.2 3 0 0 3 3 3 1 Coagulation Factor Xa inhibitory site cEGF PF12662.5 001044592.1_49824001_2 - 1.7e-06 27.7 7.5 0.00027 20.7 0.4 3.2 2 0 0 2 2 2 2 Complement Clr-like EGF-like Trypsin_2 PF13365.4 001044592.1_49824001_2 - 3.7e-05 24.5 0.0 8.7e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain hEGF PF12661.5 001044592.1_49824001_2 - 9.2e-05 22.8 13.7 0.0014 19.1 5.6 4.2 2 1 0 2 2 2 1 Human growth factor-like EGF DUF1986 PF09342.9 001044592.1_49824001_2 - 0.016 15.5 0.0 0.026 14.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) EGF_3 PF12947.5 001044592.1_49824001_2 - 4.4 7.5 32.1 0.49 10.5 7.4 3.2 3 0 0 3 3 3 0 EGF domain EGF_2 PF07974.11 001044592.1_49824001_2 - 7.2 6.9 35.8 0.033 14.4 14.0 3.9 3 0 0 3 3 3 0 EGF-like domain EGF_CA PF07645.13 001044592.1_49824001_2 - 7.7 6.7 30.0 0.063 13.4 10.4 3.2 3 0 0 3 3 3 0 Calcium-binding EGF domain ELO PF01151.16 001167647.2_49822001_2 - 3.6e-63 213.3 19.5 4.5e-63 213.0 19.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family CC2-LZ PF16516.3 001145987.1_49824001_1 - 4.3e-07 30.1 23.0 4.3e-07 30.1 23.0 6.2 4 2 1 5 5 5 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator ATG16 PF08614.9 001145987.1_49824001_1 - 0.0014 18.7 0.1 0.0014 18.7 0.1 4.6 3 1 0 4 4 4 1 Autophagy protein 16 (ATG16) Filament PF00038.19 001145987.1_49824001_1 - 0.0068 15.9 24.9 0.0068 15.9 24.9 4.8 4 1 0 4 4 4 1 Intermediate filament protein Myc-LZ PF02344.13 001145987.1_49824001_1 - 0.023 14.6 1.9 0.023 14.6 1.9 4.0 4 0 0 4 4 4 0 Myc leucine zipper domain DUF4407 PF14362.4 001145987.1_49824001_1 - 0.28 10.4 50.3 0.0086 15.3 19.9 3.5 2 1 2 4 4 4 0 Domain of unknown function (DUF4407) Trans_reg_C PF00486.26 001145987.1_49824001_1 - 1.5 8.8 5.7 3.3 7.7 0.3 3.3 2 1 1 3 3 3 0 Transcriptional regulatory protein, C terminal Speriolin_N PF15058.4 001145987.1_49824001_1 - 3 7.7 20.2 0.16 11.9 0.2 4.4 3 2 0 3 3 3 0 Speriolin N terminus Jnk-SapK_ap_N PF09744.7 001145987.1_49824001_1 - 4.3 7.4 69.6 3.8 7.6 0.1 5.2 4 1 1 5 5 5 0 JNK_SAPK-associated protein-1 Leu_zip PF15294.4 001145987.1_49824001_1 - 5.2 6.4 51.7 2.5 7.4 0.0 4.3 3 1 1 4 4 4 0 Leucine zipper Pox_F11 PF04943.10 001145987.1_49824001_1 - 9.8 5.0 12.2 33 3.3 12.2 1.8 1 1 0 1 1 1 0 Poxvirus F11 protein TIMP PF00965.15 001145985.1_49822001_3 - 6.6e-73 244.3 4.9 7.7e-73 244.0 4.9 1.0 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.19 001145985.1_49822001_3 - 0.0012 18.4 0.0 0.003 17.2 0.0 1.7 1 1 0 1 1 1 1 UNC-6/NTR/C345C module WD40 PF00400.30 001243684.1_49823001_2 - 3.7e-13 49.6 3.6 8.5e-05 23.1 0.0 5.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001243684.1_49823001_2 - 0.0016 18.6 0.0 18 5.6 0.0 3.3 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001243684.1_49823001_2 - 0.25 10.1 0.2 43 2.8 0.0 2.8 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein UBA_4 PF14555.4 001243686.1_49825001_3 - 1.8e-08 33.9 0.3 3.2e-08 33.1 0.3 1.4 1 0 0 1 1 1 1 UBA-like domain Exo_endo_phos PF03372.21 001243686.1_49825001_3 - 3e-07 30.5 0.0 4.8e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RIO1 PF01163.20 001243687.1_49825001_1 - 3.1e-75 251.8 0.0 7.6e-75 250.5 0.0 1.7 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 001243687.1_49825001_1 - 0.0045 16.8 0.0 0.1 12.4 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family STAT6_C PF14596.4 001252101.1_49828001_2 - 3e-109 363.3 17.8 5e-109 362.5 17.8 1.4 1 0 0 1 1 1 1 STAT6 C-terminal STAT_bind PF02864.13 001252101.1_49828001_2 - 4.3e-84 282.2 0.0 6.9e-83 278.2 0.0 2.0 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_int PF02865.15 001252101.1_49828001_2 - 1.3e-20 73.9 0.0 3.6e-20 72.5 0.0 1.8 1 0 0 1 1 1 1 STAT protein, protein interaction domain STAT_alpha PF01017.18 001252101.1_49828001_2 - 1.4e-13 50.9 2.0 2.4e-13 50.2 1.7 1.5 1 1 0 1 1 1 1 STAT protein, all-alpha domain SH2 PF00017.22 001252101.1_49828001_2 - 1.7e-10 40.6 0.0 3.5e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 SH2 domain ART PF01129.16 001243346.1_49824001_1 - 1.3e-48 165.1 0.3 1.6e-48 164.8 0.3 1.1 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase EMP24_GP25L PF01105.22 001243695.1_49822001_2 - 1.5e-46 158.5 0.3 1.8e-46 158.2 0.3 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Arm PF00514.21 001159312.1_49824001_1 - 1.5e-42 142.3 21.4 1e-09 38.0 0.0 8.4 9 0 0 9 9 9 6 Armadillo/beta-catenin-like repeat HEAT PF02985.20 001159312.1_49824001_1 - 9.1e-17 59.6 6.9 0.017 15.2 0.0 7.5 7 0 0 7 7 7 4 HEAT repeat HEAT_2 PF13646.4 001159312.1_49824001_1 - 4.5e-15 55.7 10.7 0.00021 21.5 0.5 5.5 3 2 1 5 5 5 4 HEAT repeats Cnd1 PF12717.5 001159312.1_49824001_1 - 1e-14 54.7 1.1 0.0032 17.4 0.0 4.8 1 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 001159312.1_49824001_1 - 6.9e-12 45.4 16.6 0.001 19.4 0.0 6.3 6 1 1 7 7 6 3 HEAT-like repeat CHASE6_C PF17150.2 001159312.1_49824001_1 - 1.1e-07 32.3 2.5 8 7.1 0.0 7.0 7 1 0 7 7 7 1 C-terminal domain of two-partite extracellular sensor domain DNA_alkylation PF08713.9 001159312.1_49824001_1 - 5.2e-07 29.5 0.1 0.89 9.1 0.0 4.4 2 1 0 4 4 4 2 DNA alkylation repair enzyme Adaptin_N PF01602.18 001159312.1_49824001_1 - 2.4e-05 23.0 5.5 0.019 13.4 1.2 3.7 1 1 1 3 3 3 2 Adaptin N terminal region Proteasom_PSMB PF10508.7 001159312.1_49824001_1 - 5.4e-05 21.8 6.2 0.0014 17.1 0.7 3.3 1 1 1 3 3 3 2 Proteasome non-ATPase 26S subunit Atx10homo_assoc PF09759.7 001159312.1_49824001_1 - 0.00011 22.1 1.6 0.54 10.2 0.1 4.8 3 2 3 6 6 6 1 Spinocerebellar ataxia type 10 protein domain CLASP_N PF12348.6 001159312.1_49824001_1 - 0.0013 18.3 0.3 2.6 7.4 0.0 3.2 3 0 0 3 3 3 2 CLASP N terminal V-ATPase_H_C PF11698.6 001159312.1_49824001_1 - 0.0089 16.0 1.1 1.3 9.0 0.1 3.8 3 1 0 4 4 4 1 V-ATPase subunit H HEAT_PBS PF03130.14 001159312.1_49824001_1 - 0.016 15.7 14.3 0.4 11.4 0.2 5.6 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat RTP1_C1 PF10363.7 001159312.1_49824001_1 - 0.018 15.0 1.0 0.055 13.5 0.3 2.3 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.5 001159312.1_49824001_1 - 0.094 13.2 0.2 1.5 9.3 0.1 2.9 1 1 2 3 3 3 0 Vacuolar 14 Fab1-binding region Rcd1 PF04078.11 001159312.1_49824001_1 - 0.11 11.7 1.4 0.32 10.1 0.2 2.3 3 1 0 3 3 3 0 Cell differentiation family, Rcd1-like DUF3361 PF11841.6 001159312.1_49824001_1 - 0.19 11.5 2.2 1.1 9.0 0.8 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3361) DUF3731 PF12531.6 001159312.1_49824001_1 - 0.32 10.6 5.0 4 7.0 0.1 3.5 3 1 0 3 3 3 0 DNA-K related protein XPC-binding PF09280.9 001159312.1_49824001_1 - 0.39 10.4 4.5 60 3.4 0.0 4.9 5 0 0 5 5 5 0 XPC-binding domain RTTN_N PF14726.4 001159312.1_49824001_1 - 0.41 11.4 2.7 8.6 7.2 0.2 3.3 3 0 0 3 3 3 0 Rotatin, an armadillo repeat protein, centriole functioning zf-C3HC4_3 PF13920.4 001252196.1_49827001_1 - 1.4e-08 34.3 10.7 1.4e-08 34.3 10.7 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001252196.1_49827001_1 - 4.2e-08 33.2 14.9 4.2e-08 33.2 14.9 2.3 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 001252196.1_49827001_1 - 1.1e-07 31.4 14.1 1.1e-07 31.4 14.1 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001252196.1_49827001_1 - 2.1e-05 24.2 13.7 2.1e-05 24.2 13.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001252196.1_49827001_1 - 9.2e-05 22.3 10.2 0.00029 20.6 10.2 2.0 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.4 001252196.1_49827001_1 - 0.00031 20.4 10.9 0.00031 20.4 10.9 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.5 001252196.1_49827001_1 - 0.00038 20.5 10.9 0.00079 19.5 10.9 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 001252196.1_49827001_1 - 0.0017 18.1 14.7 0.017 15.0 14.5 2.5 1 1 1 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.5 001252196.1_49827001_1 - 0.32 11.0 5.6 0.68 9.9 5.6 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.3 001252196.1_49827001_1 - 2.7 7.7 12.3 1.7 8.3 9.2 2.3 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_4 PF15227.4 001252196.1_49827001_1 - 8.8 6.4 17.6 0.89 9.6 11.6 2.7 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING DUF2012 PF09430.8 001243700.1_49823001_3 - 1.3e-33 115.6 0.0 1.7e-33 115.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.4 001243700.1_49823001_3 - 0.058 13.5 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain S_100 PF01023.17 001159659.1_49824001_1 - 2.1e-13 49.6 0.0 4.5e-13 48.5 0.0 1.6 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_8 PF13833.4 001159659.1_49824001_1 - 5.1e-05 22.8 0.1 9e-05 22.0 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.4 001159659.1_49824001_1 - 0.0065 16.8 0.1 0.014 15.7 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001159659.1_49824001_1 - 0.0098 15.2 0.2 0.021 14.2 0.2 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.4 001159659.1_49824001_1 - 0.069 13.0 0.1 0.61 10.1 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain Maelstrom PF13017.4 001159659.1_49824001_1 - 0.79 9.2 3.6 70 2.8 0.2 3.8 4 0 0 4 4 4 0 piRNA pathway germ-plasm component 7tm_1 PF00001.19 001243706.1_49826001_2 - 1e-18 67.4 19.8 1e-18 67.4 19.8 2.7 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) DUF4321 PF14209.4 001160079.1_49822001_3 - 0.33 10.7 0.1 0.33 10.7 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4321) ATP_bind_1 PF03029.15 001243708.1_49823001_1 - 6.7e-92 307.4 0.7 8.1e-92 307.1 0.7 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.3 001243708.1_49823001_1 - 0.00058 19.6 0.0 0.0021 17.8 0.0 1.8 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_30 PF13604.4 001243708.1_49823001_1 - 0.0055 16.3 0.0 0.0093 15.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_31 PF13614.4 001243708.1_49823001_1 - 0.015 15.1 0.0 3.4 7.4 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_10 PF12846.5 001243708.1_49823001_1 - 0.016 14.0 0.0 0.027 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain CbiA PF01656.21 001243708.1_49823001_1 - 0.019 14.9 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.4 001243708.1_49823001_1 - 0.031 14.6 0.1 0.19 12.0 0.0 2.2 2 1 1 3 3 3 0 AAA domain AAA_22 PF13401.4 001243708.1_49823001_1 - 0.039 14.1 0.0 0.082 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.15 001243708.1_49823001_1 - 0.053 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_19 PF13245.4 001243708.1_49823001_1 - 0.069 13.3 0.0 0.7 10.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.16 001243708.1_49823001_1 - 0.077 12.2 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.4 001243708.1_49823001_1 - 0.1 12.2 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ArgK PF03308.14 001243708.1_49823001_1 - 0.1 11.4 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 ArgK protein SRP54 PF00448.20 001243708.1_49823001_1 - 0.11 12.0 0.0 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_18 PF13238.4 001243708.1_49823001_1 - 0.14 12.5 0.3 0.37 11.2 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.4 001243708.1_49823001_1 - 0.18 11.8 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain PMP22_Claudin PF00822.18 001160081.1_49823001_3 - 8.3e-29 100.4 12.7 2.3e-28 99.0 12.7 1.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001160081.1_49823001_3 - 3.8e-11 43.0 13.1 7.8e-10 38.7 13.1 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF4064 PF13273.4 001160081.1_49823001_3 - 0.022 15.0 3.2 0.022 15.0 3.2 3.1 2 1 1 4 4 4 0 Protein of unknown function (DUF4064) Amastin PF07344.9 001160081.1_49823001_3 - 1.5 8.6 9.7 2.5 7.8 9.7 1.4 1 0 0 1 1 1 0 Amastin surface glycoprotein DUF308 PF03729.11 001160081.1_49823001_3 - 2.2 8.6 27.0 6.9 6.9 9.7 3.3 2 1 1 3 3 3 0 Short repeat of unknown function (DUF308) SUR7 PF06687.10 001160081.1_49823001_3 - 9.1 5.7 14.1 0.45 10.0 6.4 2.4 1 1 2 3 3 3 0 SUR7/PalI family P33MONOX PF15302.4 001252388.1_49825001_1 - 8.8e-131 435.8 5.9 1.1e-130 435.5 5.9 1.1 1 0 0 1 1 1 1 P33 mono-oxygenase NGF PF00243.16 001243713.1_49823001_1 - 1e-45 154.4 0.0 2.8e-45 153.0 0.0 1.6 2 0 0 2 2 2 1 Nerve growth factor family PMP22_Claudin PF00822.18 001160084.1_49822001_2 - 2.1e-42 144.7 6.1 2.5e-42 144.5 6.1 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001160084.1_49822001_2 - 1.5e-09 37.8 10.9 9.5e-09 35.1 10.9 1.9 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Amastin PF07344.9 001160084.1_49822001_2 - 0.0075 16.0 6.0 0.011 15.5 6.0 1.3 1 0 0 1 1 1 1 Amastin surface glycoprotein Ig_3 PF13927.4 001243714.1_49825001_1 - 1.3e-05 25.6 0.9 0.0021 18.5 0.4 2.4 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001243714.1_49825001_1 - 1.3e-05 25.3 1.1 3.1e-05 24.1 0.9 1.7 2 0 0 2 2 2 1 Immunoglobulin domain Receptor_2B4 PF11465.6 001243714.1_49825001_1 - 8.1e-05 22.6 0.1 0.00013 21.9 0.1 1.3 1 0 0 1 1 1 1 Natural killer cell receptor 2B4 I-set PF07679.14 001243714.1_49825001_1 - 0.00012 22.0 0.2 0.14 12.1 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.15 001243714.1_49825001_1 - 0.0062 16.5 2.3 0.014 15.4 0.1 2.4 2 1 1 3 3 3 1 Immunoglobulin V-set domain ig PF00047.23 001243714.1_49825001_1 - 0.14 12.2 1.5 8.3 6.5 0.3 2.4 2 0 0 2 2 2 0 Immunoglobulin domain Mit_proteolip PF08039.9 001243714.1_49825001_2 - 1.4 9.2 8.8 0.4 10.9 5.5 1.8 2 0 0 2 2 2 0 Mitochondrial proteolipid Ribosomal_L10 PF00466.18 001243715.1_49823001_2 - 1.6e-19 69.8 0.1 2.7e-19 69.0 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 DUF349 PF03993.10 001243715.1_49823001_2 - 0.093 12.9 0.1 0.093 12.9 0.1 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) Septin PF00735.16 001243793.1_49827001_2 - 1.5e-125 417.9 0.1 2.1e-125 417.5 0.1 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 001243793.1_49827001_2 - 3.5e-07 30.2 0.0 7.6e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001243793.1_49827001_2 - 6.8e-05 22.4 0.1 0.013 15.0 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001243793.1_49827001_2 - 0.00013 21.8 0.2 0.0034 17.2 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AIG1 PF04548.14 001243793.1_49827001_2 - 0.00083 18.6 0.0 0.0017 17.6 0.0 1.5 1 0 0 1 1 1 1 AIG1 family Ras PF00071.20 001243793.1_49827001_2 - 0.0032 17.0 0.0 0.0053 16.2 0.0 1.3 1 0 0 1 1 1 1 Ras family Dynamin_N PF00350.21 001243793.1_49827001_2 - 0.0074 16.2 0.2 0.25 11.3 0.0 2.5 1 1 1 2 2 2 1 Dynamin family Roc PF08477.11 001243793.1_49827001_2 - 0.024 14.7 0.0 0.041 14.0 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 001243793.1_49827001_2 - 0.026 14.8 0.0 0.059 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 001243793.1_49827001_2 - 0.041 14.0 0.1 0.13 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.4 001243793.1_49827001_2 - 0.044 13.4 0.0 0.086 12.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.25 001243793.1_49827001_2 - 0.05 14.0 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Gtr1_RagA PF04670.10 001243793.1_49827001_2 - 0.18 11.0 0.3 1.5 8.0 0.0 2.0 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Pribosyltran_N PF13793.4 001243801.1_49825001_3 - 3.1e-46 156.0 0.4 6.4e-46 154.9 0.1 1.7 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.4 001243801.1_49825001_3 - 1.5e-43 148.9 3.4 1.1e-36 126.5 1.5 2.2 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.25 001243801.1_49825001_3 - 1.1e-13 50.9 0.8 3.2e-13 49.3 0.3 1.9 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.4 001243801.1_49825001_3 - 0.001 18.4 0.1 0.0017 17.7 0.1 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Ras PF00071.20 001243802.1_49824001_2 - 1.1e-65 220.1 0.5 1.4e-65 219.7 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001243802.1_49824001_2 - 7.5e-33 113.2 0.1 1.2e-32 112.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001243802.1_49824001_2 - 1.3e-15 57.2 0.3 1.9e-15 56.6 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001243802.1_49824001_2 - 7.8e-05 22.0 0.1 0.0001 21.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001243802.1_49824001_2 - 0.0037 16.6 0.1 0.0056 16.0 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 001243802.1_49824001_2 - 0.022 14.7 0.0 0.038 13.9 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001243802.1_49824001_2 - 0.035 13.5 0.1 0.056 12.8 0.1 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001243802.1_49824001_2 - 0.059 13.1 0.2 11 5.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DUF3963 PF13124.4 001243802.1_49824001_2 - 0.11 12.4 0.8 0.2 11.5 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3963) Cyclin_N PF00134.21 001078678.1_49822001_1 - 6.7e-36 122.8 0.8 8.9e-36 122.4 0.8 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001078678.1_49822001_1 - 4.4e-18 65.4 0.0 2.6e-17 62.9 0.0 2.1 2 0 0 2 2 2 1 Cyclin, C-terminal domain K-cyclin_vir_C PF09080.8 001078678.1_49822001_1 - 0.019 15.3 0.2 0.031 14.5 0.2 1.3 1 0 0 1 1 1 0 K cyclin, C terminal Ribosomal_L28e PF01778.15 001243808.1_49825001_1 - 1.8e-36 125.2 3.1 4.9e-36 123.8 0.9 2.3 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.12 001243808.1_49825001_1 - 2.5e-30 104.9 12.9 2.5e-30 104.9 12.9 2.2 2 0 0 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.8 001243808.1_49825001_1 - 0.00039 19.8 13.1 0.00051 19.4 13.1 1.1 1 0 0 1 1 1 1 BUD22 SDA1 PF05285.10 001243808.1_49825001_1 - 2.6 7.3 20.3 3.5 6.9 20.3 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.10 001243808.1_49825001_1 - 6.1 4.8 21.7 7.9 4.4 21.7 1.0 1 0 0 1 1 1 0 Nop14-like family WH1 PF00568.21 001243811.1_49824001_1 - 2.7e-35 120.5 0.2 4.8e-35 119.7 0.2 1.4 1 0 0 1 1 1 1 WH1 domain GAS PF13851.4 001243811.1_49824001_1 - 0.00017 20.9 29.9 0.00017 20.9 29.9 1.9 2 1 0 2 2 2 1 Growth-arrest specific micro-tubule binding HMMR_N PF15905.3 001243811.1_49824001_1 - 0.0014 18.0 24.3 0.0014 18.0 24.3 1.7 2 0 0 2 2 2 1 Hyaluronan mediated motility receptor N-terminal CALCOCO1 PF07888.9 001243811.1_49824001_1 - 0.003 16.1 22.3 0.003 16.1 22.3 1.6 2 0 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like DUF1664 PF07889.10 001243811.1_49824001_1 - 0.041 13.7 15.9 0.42 10.5 8.7 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF4407 PF14362.4 001243811.1_49824001_1 - 0.1 11.8 14.0 0.19 10.9 14.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Nsp1_C PF05064.11 001243811.1_49824001_1 - 0.17 11.5 23.9 1.1 9.0 11.5 2.5 1 1 1 2 2 2 0 Nsp1-like C-terminal region DUF3508 PF12018.6 001243811.1_49824001_1 - 0.24 10.7 20.0 0.71 9.2 8.8 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF3508) Reo_sigmaC PF04582.10 001243811.1_49824001_1 - 0.34 10.1 7.2 2.2 7.5 1.9 2.3 1 1 1 2 2 2 0 Reovirus sigma C capsid protein FUSC PF04632.10 001243811.1_49824001_1 - 0.46 8.8 8.7 0.63 8.4 8.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family APG6 PF04111.10 001243811.1_49824001_1 - 0.69 9.1 34.7 0.04 13.2 20.4 2.4 1 1 1 2 2 2 0 Autophagy protein Apg6 ATG16 PF08614.9 001243811.1_49824001_1 - 1.1 9.3 41.3 4.3 7.3 21.5 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Fib_alpha PF08702.8 001243811.1_49824001_1 - 1.3 9.1 17.8 3.8 7.5 12.1 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF3584 PF12128.6 001243811.1_49824001_1 - 1.6 6.0 26.7 7.7 3.8 26.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) SPT16 PF08644.9 001243811.1_49824001_1 - 1.6 8.7 10.4 8.8 6.4 6.4 2.4 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) NPV_P10 PF05531.10 001243811.1_49824001_1 - 1.8 9.0 12.9 1.8 8.9 1.0 2.9 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein EzrA PF06160.10 001243811.1_49824001_1 - 2.1 6.3 27.4 0.039 12.0 19.0 1.9 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA IFT57 PF10498.7 001243811.1_49824001_1 - 2.2 7.1 27.9 3.1 6.6 5.2 2.0 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Prominin PF05478.9 001243811.1_49824001_1 - 2.2 6.0 11.2 3.6 5.3 11.2 1.3 1 0 0 1 1 1 0 Prominin DUF3450 PF11932.6 001243811.1_49824001_1 - 2.3 7.3 27.7 3.7 6.6 16.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) TMF_TATA_bd PF12325.6 001243811.1_49824001_1 - 2.6 8.1 37.0 0.059 13.5 21.1 2.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding BLOC1_2 PF10046.7 001243811.1_49824001_1 - 2.6 8.3 27.2 0.037 14.2 6.7 3.3 2 1 2 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HemX PF04375.12 001243811.1_49824001_1 - 4.1 6.5 24.4 0.69 9.0 10.0 2.3 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF342 PF03961.11 001243811.1_49824001_1 - 4.8 5.5 19.8 15 3.9 18.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Phlebovirus_NSM PF07246.9 001243811.1_49824001_1 - 4.8 6.3 13.6 4.6 6.4 12.2 1.6 1 1 1 2 2 2 0 Phlebovirus nonstructural protein NS-M FTCD_C PF04961.10 001243811.1_49824001_1 - 4.9 6.7 7.2 3.6 7.2 2.8 2.3 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase Fzo_mitofusin PF04799.11 001243811.1_49824001_1 - 5.2 6.4 20.6 4.2 6.7 13.9 2.7 1 1 1 2 2 2 0 fzo-like conserved region DUF641 PF04859.10 001243811.1_49824001_1 - 8.1 6.7 22.8 41 4.4 14.6 3.4 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) Phage_GP20 PF06810.9 001243811.1_49824001_1 - 8.1 6.1 24.1 24 4.5 13.7 3.2 1 1 2 3 3 3 0 Phage minor structural protein GP20 Laminin_II PF06009.10 001243811.1_49824001_1 - 8.4 6.3 22.1 0.51 10.2 9.5 2.7 2 1 1 3 3 3 0 Laminin Domain II Cluap1 PF10234.7 001243811.1_49824001_1 - 8.8 5.5 27.4 3.7 6.7 8.9 2.4 1 1 1 2 2 2 0 Clusterin-associated protein-1 FlgM PF04316.11 001243811.1_49824001_1 - 9.1 6.6 9.3 0.53 10.5 1.2 2.8 3 0 0 3 3 2 0 Anti-sigma-28 factor, FlgM Integrase_DNA PF02920.13 001243811.1_49824001_3 - 0.032 13.8 0.0 0.063 12.8 0.0 1.4 1 0 0 1 1 1 0 DNA binding domain of tn916 integrase PMP22_Claudin PF00822.18 001161641.1_49822001_1 - 2.6e-21 76.1 9.8 3.7e-21 75.6 9.8 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family DUF3273 PF11677.6 001161641.1_49822001_1 - 0.0085 15.3 2.0 0.042 13.0 1.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3273) Claudin_2 PF13903.4 001161641.1_49822001_1 - 0.023 14.3 17.2 1.1 8.9 16.0 2.7 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction PRA1 PF03208.17 001161641.1_49822001_1 - 0.36 10.3 3.4 16 5.0 0.0 2.2 2 1 0 2 2 2 0 PRA1 family protein DUF2583 PF10762.7 001161641.1_49822001_1 - 1.1 9.5 3.8 0.4 11.0 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2583) zf-LITAF-like PF10601.7 001161641.1_49822001_1 - 5.4 7.2 17.5 0.15 12.2 3.3 3.5 2 1 1 3 3 3 0 LITAF-like zinc ribbon domain SLAM PF06214.9 001243820.1_49824001_1 - 1.7e-65 218.6 0.4 2.6e-65 218.0 0.4 1.3 1 0 0 1 1 1 1 Signaling lymphocytic activation molecule (SLAM) protein Ig_3 PF13927.4 001243820.1_49824001_1 - 6.9e-05 23.3 0.4 0.0028 18.1 0.2 2.8 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.4 001243820.1_49824001_1 - 0.0011 19.1 0.2 0.0036 17.5 0.2 1.9 1 0 0 1 1 1 1 Immunoglobulin domain Receptor_2B4 PF11465.6 001243820.1_49824001_1 - 0.0015 18.6 0.0 0.0027 17.8 0.0 1.4 1 0 0 1 1 1 1 Natural killer cell receptor 2B4 DUF1191 PF06697.10 001243820.1_49824001_1 - 0.13 11.4 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) Sec61_beta PF03911.14 001243825.1_49822001_3 - 3e-19 68.6 0.0 5.7e-19 67.7 0.0 1.5 1 0 0 1 1 1 1 Sec61beta family Hist_deacetyl PF00850.17 001243827.1_49824001_1 - 6.8e-79 265.4 0.1 1e-78 264.8 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Hydrolase PF00702.24 001243830.1_49825001_1 - 0.0018 18.5 0.1 0.0025 18.0 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PRIMA1 PF16101.3 001243830.1_49825001_1 - 1.6 8.6 4.5 3.1 7.7 4.5 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 GATA PF00320.25 213879.1_49826001_1 - 1.2e-28 98.3 19.4 2.8e-14 52.3 6.3 2.6 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.10 213879.1_49826001_1 - 0.0022 17.3 10.9 0.11 11.8 0.5 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding Auto_anti-p27 PF06677.10 213879.1_49826001_1 - 7 6.8 8.5 6.5 6.9 0.4 2.6 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Coprogen_oxidas PF01218.16 001243844.1_49826001_2 - 1.9e-139 463.3 0.0 2.3e-139 463.0 0.0 1.1 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase 7tm_1 PF00001.19 001243855.1_49824001_3 - 1.8e-29 102.7 21.0 4.4e-29 101.4 21.0 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001243855.1_49824001_3 - 1.4e-06 27.8 10.9 2e-06 27.3 10.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001243855.1_49824001_3 - 0.0057 16.3 15.6 0.0068 16.0 2.9 2.1 2 0 0 2 2 2 2 Olfactory receptor Lep_receptor_Ig PF06328.9 001097432.1_49827001_2 - 1.8e-31 107.8 0.4 1.8e-31 107.8 0.4 2.8 3 0 0 3 3 3 1 Ig-like C2-type domain fn3 PF00041.19 001097432.1_49827001_2 - 8.7e-29 99.6 10.5 1.6e-09 37.9 0.1 5.7 6 0 0 6 6 6 4 Fibronectin type III domain EpoR_lig-bind PF09067.8 001097432.1_49827001_2 - 5.2e-07 29.7 0.1 1.9e-06 27.9 0.1 2.0 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding IL6Ra-bind PF09240.8 001097432.1_49827001_2 - 1.1e-06 28.8 0.1 3.7e-06 27.1 0.1 1.9 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding Pur_ac_phosph_N PF16656.3 001097432.1_49827001_2 - 8.8e-05 22.9 12.5 0.01 16.2 0.1 4.4 3 1 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 001097432.1_49827001_2 - 0.00012 22.3 0.0 0.16 12.2 0.0 2.8 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.3 001097432.1_49827001_2 - 0.0014 18.6 0.0 0.012 15.6 0.0 2.6 3 0 0 3 3 3 1 Fibronectin type III domain PC-Esterase PF13839.4 001243864.1_49824001_3 - 3.3e-07 30.2 0.1 3.3e-07 30.2 0.1 2.3 2 1 0 2 2 2 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Peptidase_M14 PF00246.22 001097439.1_49825001_1 - 2.2e-82 277.0 0.0 2.7e-82 276.7 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.4 001097439.1_49825001_1 - 2.2e-16 59.8 0.0 3.2e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.4 001097439.1_49825001_1 - 3.2e-07 30.1 0.0 5.1e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.12 001097439.1_49825001_1 - 0.04 12.8 0.1 0.15 11.0 0.1 1.7 1 1 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family adh_short PF00106.23 001243866.1_49824001_1 - 2.6e-39 134.6 0.0 3.6e-39 134.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001243866.1_49824001_1 - 5e-24 85.0 0.0 6.9e-24 84.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.8 001243866.1_49824001_1 - 0.0004 19.7 0.0 0.00063 19.0 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.8 001243866.1_49824001_1 - 0.02 14.7 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 KR domain BAR PF03114.16 001097440.1_49825001_2 - 1.8e-44 152.1 12.2 2.5e-44 151.6 12.2 1.1 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.4 001097440.1_49825001_2 - 3.3e-10 39.5 0.1 7.2e-10 38.4 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001097440.1_49825001_2 - 1.3e-06 27.9 0.0 3.4e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001097440.1_49825001_2 - 2.2e-06 27.0 0.1 4.9e-06 25.9 0.1 1.6 1 0 0 1 1 1 1 SH3 domain BAR_3 PF16746.3 001097440.1_49825001_2 - 0.00027 20.6 12.8 0.00044 19.9 9.1 2.2 1 1 1 2 2 2 1 BAR domain of APPL family Jnk-SapK_ap_N PF09744.7 001097440.1_49825001_2 - 0.015 15.4 2.8 0.015 15.4 2.8 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 OmpH PF03938.12 001097440.1_49825001_2 - 0.031 14.1 14.3 0.031 14.1 1.4 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF3104 PF11302.6 001097440.1_49825001_2 - 0.14 11.8 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) IncA PF04156.12 001097440.1_49825001_2 - 0.16 11.6 5.2 3.9 7.1 0.3 2.4 2 0 0 2 2 2 0 IncA protein Baculo_PEP_C PF04513.10 001097440.1_49825001_2 - 1.4 8.8 4.3 5.7 6.8 0.3 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.10 001097440.1_49825001_2 - 5.3 6.9 9.4 1.1 9.2 0.9 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.7 001097440.1_49825001_2 - 5.3 7.3 14.5 0.66 10.2 4.5 3.0 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF108 PF01958.16 001243870.1_49823001_3 - 3.5e-23 81.6 0.1 6.1e-23 80.9 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF108 NAD_binding_3 PF03447.14 001243870.1_49823001_3 - 5.9e-18 65.5 0.0 8.9e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain F420_oxidored PF03807.15 001243870.1_49823001_3 - 0.039 14.4 0.0 0.065 13.7 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.18 001243870.1_49823001_3 - 0.055 13.4 0.0 0.12 12.3 0.0 1.5 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase SOCS PF12610.6 001162889.1_49825001_3 - 5.3e-21 74.6 2.8 1.2e-20 73.5 2.8 1.6 1 0 0 1 1 1 1 Suppressor of cytokine signalling SOCS_box PF07525.14 001162889.1_49825001_3 - 2e-10 40.7 0.1 4.2e-10 39.7 0.1 1.6 1 0 0 1 1 1 1 SOCS box SH2 PF00017.22 001162889.1_49825001_3 - 1.6e-07 31.2 0.0 2.8e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SOCS PF12610.6 001162890.1_49825001_3 - 5.8e-15 55.3 0.9 5.8e-15 55.3 0.9 3.1 2 1 1 3 3 3 1 Suppressor of cytokine signalling SOCS_box PF07525.14 001162890.1_49825001_3 - 2.4e-09 37.2 0.0 5.5e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 SOCS box SH2 PF00017.22 001162890.1_49825001_3 - 1.1e-08 34.8 0.0 2.2e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 SH2 domain LRR_8 PF13855.4 001243889.1_49826001_2 - 2.8e-39 132.5 31.2 1.2e-12 47.3 2.9 4.5 3 1 3 6 6 6 6 Leucine rich repeat LRR_4 PF12799.5 001243889.1_49826001_2 - 2e-16 59.6 23.0 2.9e-05 24.2 0.7 6.3 2 2 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001243889.1_49826001_2 - 2.5e-12 46.8 1.2 9.6e-07 28.7 0.2 3.2 1 1 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001243889.1_49826001_2 - 6.1e-11 42.0 6.9 7e-06 25.5 0.3 2.3 2 0 0 2 2 2 2 Leucine-rich repeat LRRNT PF01462.16 001243889.1_49826001_2 - 7.8e-07 28.5 11.4 9.7e-07 28.2 3.4 3.9 4 0 0 4 4 4 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 001243889.1_49826001_2 - 0.022 15.1 13.3 2.5 8.8 0.4 7.2 6 2 1 7 7 7 0 Leucine Rich Repeat Vps51 PF08700.9 001243889.1_49826001_3 - 0.081 12.9 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Vps51/Vps67 Trypsin PF00089.24 001162891.1_49822001_1 - 1.9e-82 276.2 5.5 2.1e-82 276.1 5.5 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001162891.1_49822001_1 - 0.00014 22.6 0.1 0.0002 22.1 0.1 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001162891.1_49822001_1 - 0.012 15.9 0.5 0.037 14.3 0.1 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF1986) Glutaredoxin PF00462.22 001243896.1_49823001_3 - 4e-37 126.1 0.1 1.8e-17 63.1 0.0 3.4 3 0 0 3 3 3 2 Glutaredoxin Thioredoxin PF00085.18 001243896.1_49823001_3 - 5.1e-19 68.0 0.0 1e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.4 001243896.1_49823001_3 - 7e-07 29.5 0.0 3.8e-06 27.2 0.0 2.2 2 1 0 2 2 2 1 Thioredoxin-like domain Phosducin PF02114.14 001243896.1_49823001_3 - 1.8e-06 27.0 0.0 2.8e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Phosducin SH3BGR PF04908.13 001243896.1_49823001_3 - 2.6e-06 27.4 0.0 0.05 13.6 0.0 2.5 2 0 0 2 2 2 2 SH3-binding, glutamic acid-rich protein DIM1 PF02966.14 001243896.1_49823001_3 - 5.8e-05 22.8 0.0 0.00024 20.7 0.0 1.9 2 0 0 2 2 2 1 Mitosis protein DIM1 HyaE PF07449.9 001243896.1_49823001_3 - 0.00024 20.9 0.1 0.0014 18.5 0.0 2.2 2 1 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Thioredoxin_3 PF13192.4 001243896.1_49823001_3 - 0.0015 18.4 0.0 0.0094 15.8 0.0 2.2 2 1 0 2 2 2 1 Thioredoxin domain Thioredoxin_8 PF13905.4 001243896.1_49823001_3 - 0.0081 16.3 0.0 0.19 11.9 0.0 2.7 1 1 1 2 2 2 1 Thioredoxin-like OST3_OST6 PF04756.11 001243896.1_49823001_3 - 0.011 15.0 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.4 001243896.1_49823001_3 - 0.058 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin TraF PF13728.4 001243896.1_49823001_3 - 0.095 12.4 0.1 0.49 10.1 0.0 2.1 3 0 0 3 3 3 0 F plasmid transfer operon protein FGF PF00167.16 001163410.1_49822001_2 - 3e-18 66.0 0.0 3.8e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 Fibroblast growth factor IL8 PF00048.18 001256774.1_49822001_3 - 4.1e-21 74.7 3.9 7.2e-21 74.0 3.9 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Ras PF00071.20 001243906.1_49823001_3 - 1e-44 151.9 0.2 1.2e-44 151.6 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001243906.1_49823001_3 - 5.3e-28 97.5 0.0 8.9e-28 96.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001243906.1_49823001_3 - 1e-12 47.7 0.0 1.3e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 001243906.1_49823001_3 - 0.0076 16.0 0.0 0.25 11.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 001243906.1_49823001_3 - 0.029 14.3 0.0 0.045 13.7 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001243906.1_49823001_3 - 0.05 12.8 0.0 0.078 12.2 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region FeoB_N PF02421.16 001243906.1_49823001_3 - 0.052 12.9 0.0 0.083 12.3 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B Ank_4 PF13637.4 001256778.1_49823001_3 - 1.7e-17 63.4 0.0 3.1e-11 43.4 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 001256778.1_49823001_3 - 6.8e-15 55.3 0.1 1.9e-14 53.9 0.0 1.8 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001256778.1_49823001_3 - 1.7e-14 53.5 0.0 3.5e-08 33.4 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 001256778.1_49823001_3 - 2.4e-12 46.6 0.2 7e-06 26.1 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.4 001256778.1_49823001_3 - 5.3e-12 44.7 0.1 5.9e-06 26.1 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Calcipressin PF04847.10 001243913.1_49825001_3 - 2.4e-62 209.8 0.7 3.4e-62 209.4 0.7 1.1 1 0 0 1 1 1 1 Calcipressin F-box-like PF12937.5 001243927.1_49824001_2 - 0.062 13.1 1.3 0.15 11.8 1.3 1.6 1 0 0 1 1 1 0 F-box-like Cyclin_N PF00134.21 001243931.1_49826001_2 - 4e-41 139.6 2.1 9.1e-41 138.5 2.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001243931.1_49826001_2 - 5.1e-21 74.8 0.2 1.1e-20 73.8 0.2 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain COX7a PF02238.13 001097484.1_49822001_3 - 2.1e-09 37.5 0.0 4.8e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII Tox-WTIP PF15654.4 001097484.1_49822001_3 - 0.0059 16.4 0.2 0.0096 15.7 0.2 1.2 1 0 0 1 1 1 1 Toxin with a conserved tryptophan and TIP tripeptide motif COPIIcoated_ERV PF07970.10 001243932.1_49823001_2 - 3.5e-48 164.2 0.1 5.1e-48 163.7 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.4 001243932.1_49823001_2 - 5.6e-24 84.2 0.3 1.1e-23 83.3 0.3 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) HSBP1 PF06825.10 001097485.1_49822001_2 - 3.5e-30 103.5 8.2 5e-30 103.0 8.2 1.2 1 0 0 1 1 1 1 Heat shock factor binding protein 1 CLZ PF16526.3 001097485.1_49822001_2 - 0.0032 17.6 0.1 0.0058 16.8 0.1 1.4 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_I PF06008.12 001097485.1_49822001_2 - 0.025 14.2 0.0 0.035 13.7 0.0 1.2 1 0 0 1 1 1 0 Laminin Domain I Baculo_PEP_C PF04513.10 001097485.1_49822001_2 - 0.036 14.0 0.3 0.066 13.1 0.3 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus WGG PF10273.7 001097485.1_49822001_2 - 0.19 12.3 1.9 17 6.0 0.2 2.9 2 1 1 3 3 3 0 Pre-rRNA-processing protein TSR2 Citrate_bind PF16114.3 001257276.1_49829001_1 - 2.7e-91 303.8 0.1 4.6e-91 303.0 0.1 1.4 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding Citrate_synt PF00285.19 001257276.1_49829001_1 - 1.9e-21 76.4 0.0 3.3e-18 65.8 0.0 3.0 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.17 001257276.1_49829001_1 - 1.9e-13 50.4 0.1 3.6e-13 49.5 0.1 1.5 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.17 001257276.1_49829001_1 - 2.3e-12 47.3 0.0 4.7e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 CoA binding domain ATP-grasp_2 PF08442.8 001257276.1_49829001_1 - 7.5e-05 22.2 0.0 0.00013 21.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.4 001257276.1_49829001_1 - 0.0025 17.5 0.0 0.0085 15.8 0.0 1.9 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain ADH_zinc_N PF00107.24 001243939.1_49823001_2 - 6.3e-26 90.7 0.1 1.1e-25 89.9 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001243939.1_49823001_2 - 2.6e-24 85.1 1.0 5.5e-24 84.0 1.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.3 001243939.1_49823001_2 - 1.4e-05 24.6 0.0 2e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.12 001243939.1_49823001_2 - 0.00097 18.6 0.2 0.0018 17.8 0.2 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ADH_zinc_N_2 PF13602.4 001243939.1_49823001_2 - 0.0011 19.9 0.0 0.002 19.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.17 001243939.1_49823001_2 - 0.027 13.7 0.3 0.042 13.1 0.3 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Homeobox PF00046.27 001257354.1_49823001_1 - 2.4e-20 71.9 5.7 3.9e-20 71.3 5.7 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001257354.1_49823001_1 - 0.12 12.2 0.2 0.28 11.0 0.2 1.6 1 0 0 1 1 1 0 Homeobox KN domain MHC_I_3 PF16497.3 001097492.1_49822001_1 - 5.1e-70 234.9 0.4 6.5e-70 234.5 0.4 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001097492.1_49822001_1 - 4e-10 39.9 0.0 1.2e-09 38.4 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001097492.1_49822001_1 - 0.16 11.4 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 HECT PF00632.23 001243181.2_49828001_2 - 1.9e-92 309.9 1.1 2.2e-92 309.7 0.2 1.6 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.3 001243181.2_49828001_2 - 1.9e-18 66.3 3.7 3.9e-18 65.3 3.7 1.6 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A PCM1_C PF15717.3 001243181.2_49828001_2 - 0.029 12.9 5.0 0.049 12.2 5.0 1.2 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus HECT PF00632.23 001258279.1_49828001_2 - 1.6e-92 310.1 1.0 2e-92 309.8 0.2 1.6 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.3 001258279.1_49828001_2 - 1.8e-18 66.4 3.7 3.7e-18 65.4 3.7 1.6 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A PCM1_C PF15717.3 001258279.1_49828001_2 - 0.027 13.0 5.0 0.046 12.3 5.0 1.2 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus Tetraspannin PF00335.18 001244061.1_49824001_3 - 2.4e-48 164.6 10.0 3.9e-48 163.9 10.0 1.3 1 0 0 1 1 1 1 Tetraspanin family 4HB_MCP_1 PF12729.5 001244061.1_49824001_3 - 0.0024 17.3 0.3 0.012 15.0 0.0 2.0 2 0 0 2 2 2 1 Four helix bundle sensory module for signal transduction LIM PF00412.20 213946.2_49823001_2 - 3.8e-47 158.2 59.6 1.6e-12 47.3 2.7 5.1 5 0 0 5 5 5 5 LIM domain DUF2102 PF09875.7 213946.2_49823001_2 - 0.18 11.4 0.5 0.35 10.5 0.5 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2102) Porphobil_deam PF01379.18 001097412.1_49823001_3 - 5.3e-78 261.1 0.0 7.1e-78 260.7 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.13 001097412.1_49823001_3 - 2.5e-21 75.7 0.0 1.5e-20 73.2 0.0 2.3 1 1 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Sulfatase PF00884.21 213933.1_49824001_1 - 1.1e-75 254.8 0.0 1.4e-75 254.4 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.4 213933.1_49824001_1 - 7.5e-27 94.4 0.1 1.2e-26 93.7 0.1 1.3 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.20 213933.1_49824001_1 - 0.00019 21.0 0.0 0.011 15.2 0.0 2.1 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.3 213933.1_49824001_1 - 0.031 14.4 0.0 9.1 6.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4976) DUF1501 PF07394.10 213933.1_49824001_1 - 0.039 12.9 0.0 0.057 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) MARVEL PF01284.21 001244066.1_49822001_1 - 3.2e-31 108.2 3.8 3.9e-31 107.9 3.8 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF4064 PF13273.4 001244066.1_49822001_1 - 0.035 14.3 0.1 5.6 7.2 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) Ribosomal_S17_N PF16205.3 001244070.1_49822001_1 - 5.1e-37 125.9 0.8 1.2e-36 124.8 0.8 1.7 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.18 001244070.1_49822001_1 - 3.4e-29 100.6 1.7 5.5e-29 100.0 1.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 ADH_zinc_N PF00107.24 001244082.1_49823001_1 - 2.4e-19 69.4 0.0 3.9e-19 68.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001244082.1_49823001_1 - 1.5e-09 37.5 0.1 3.6e-09 36.4 0.1 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.4 001244082.1_49823001_1 - 1.3e-07 32.6 0.0 2.9e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PALP PF00291.23 001244082.1_49823001_1 - 0.02 14.2 0.0 0.033 13.5 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme UIM PF02809.18 001244082.1_49823001_1 - 0.052 13.3 0.1 0.15 11.9 0.1 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif RRM_1 PF00076.20 001244096.1_49825001_3 - 6.1e-23 80.3 0.1 9.3e-23 79.7 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM1CTR PF08081.9 001244096.1_49825001_3 - 1.6e-22 79.2 14.1 1.6e-22 79.2 14.1 8.8 5 2 3 8 8 8 1 RBM1CTR (NUC064) family RRM_7 PF16367.3 001244096.1_49825001_3 - 0.0052 16.8 0.0 0.01 15.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.4 001244096.1_49825001_3 - 0.036 13.5 0.0 0.066 12.7 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001244096.1_49825001_3 - 0.11 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif NAT PF04768.11 001097520.1_49823001_1 - 2e-48 164.2 0.0 2.7e-48 163.7 0.0 1.2 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase AA_kinase PF00696.26 001097520.1_49823001_1 - 7e-07 28.9 0.1 3e-06 26.9 0.0 1.9 1 1 1 2 2 2 1 Amino acid kinase family Acetyltransf_1 PF00583.23 001097520.1_49823001_1 - 0.034 14.3 0.0 0.073 13.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 001097520.1_49823001_1 - 0.037 13.8 0.0 0.073 12.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain POTRA_2 PF08479.9 001097520.1_49823001_1 - 0.09 12.5 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 POTRA domain, ShlB-type V-set PF07686.15 001244102.1_49824001_3 - 2.2e-16 59.8 1.7 6.4e-10 39.0 0.1 3.4 2 1 1 3 3 3 3 Immunoglobulin V-set domain Ig_3 PF13927.4 001244102.1_49824001_3 - 1.1e-13 51.5 0.2 1.8e-09 37.9 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001244102.1_49824001_3 - 1.3e-12 47.8 0.7 3.8e-09 36.6 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001244102.1_49824001_3 - 9.8e-12 44.7 0.0 4.3e-08 33.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 001244102.1_49824001_3 - 1.3e-09 38.0 0.2 2.6e-05 24.2 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain HLH PF00010.24 001244104.1_49823001_3 - 7.5e-10 38.5 1.8 7.5e-10 38.5 1.8 2.5 3 1 1 4 4 4 1 Helix-loop-helix DNA-binding domain DUF3829 PF12889.5 001244104.1_49823001_3 - 0.029 13.7 0.0 0.041 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) T3SS_needle_E PF08988.8 001244104.1_49823001_3 - 0.13 12.3 13.1 0.044 13.9 1.7 2.4 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle Exonuc_VII_L PF02601.13 001244104.1_49823001_3 - 0.22 10.9 3.7 0.29 10.5 3.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit APG6 PF04111.10 001244104.1_49823001_3 - 0.68 9.1 5.6 0.92 8.7 5.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Zwint PF15556.4 001244104.1_49823001_3 - 2.8 7.2 13.2 4.2 6.7 13.2 1.1 1 0 0 1 1 1 0 ZW10 interactor Musclin PF11037.6 001098597.1_49822001_3 - 7.1e-71 236.1 0.1 8.6e-71 235.9 0.1 1.1 1 0 0 1 1 1 1 Insulin-resistance promoting peptide in skeletal muscle MH2 PF03166.12 213965.1_49825001_3 - 4.6e-76 255.0 1.5 6.1e-76 254.6 1.5 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 213965.1_49825001_3 - 4e-42 142.5 1.2 9.6e-42 141.3 1.2 1.7 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.7 213965.1_49825001_3 - 0.00027 20.7 0.0 0.00045 19.9 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 DUF4223 PF13978.4 213965.1_49825001_3 - 0.19 11.6 0.8 0.41 10.5 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4223) Cyclin_C_2 PF16899.3 001166313.1_49822001_1 - 2.7e-26 91.8 0.6 3.2e-24 85.2 0.2 2.6 3 0 0 3 3 3 2 Cyclin C-terminal domain Cyclin_N PF00134.21 001166313.1_49822001_1 - 2.7e-09 36.8 0.1 7.4e-09 35.3 0.1 1.8 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001166313.1_49822001_1 - 0.019 14.9 0.7 0.18 11.7 0.1 2.3 2 1 1 3 3 3 0 Cyclin, C-terminal domain AAA PF00004.27 001244151.1_49824001_3 - 4.3e-43 146.8 0.0 1e-42 145.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.12 001244151.1_49824001_3 - 4.4e-07 30.1 0.1 1.2e-06 28.6 0.0 1.7 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.4 001244151.1_49824001_3 - 3.2e-06 27.3 0.2 0.0018 18.4 0.2 2.4 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.11 001244151.1_49824001_3 - 2.8e-05 23.3 0.0 5e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.12 001244151.1_49824001_3 - 6.2e-05 22.9 0.1 0.00054 19.8 0.1 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.10 001244151.1_49824001_3 - 9.1e-05 21.7 0.0 0.00017 20.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.4 001244151.1_49824001_3 - 0.00011 22.5 0.1 0.0031 17.8 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain Prot_ATP_ID_OB PF16450.3 001244151.1_49824001_3 - 0.0015 17.9 0.1 0.003 16.9 0.1 1.4 1 0 0 1 1 1 1 Proteasomal ATPase OB/ID domain IstB_IS21 PF01695.15 001244151.1_49824001_3 - 0.0018 18.0 0.0 0.0041 16.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.4 001244151.1_49824001_3 - 0.0047 17.0 0.0 0.0093 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 001244151.1_49824001_3 - 0.005 17.2 0.0 0.011 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.4 001244151.1_49824001_3 - 0.0066 15.9 0.4 0.4 10.1 0.1 2.4 1 1 1 2 2 2 1 AAA domain ATPase PF06745.11 001244151.1_49824001_3 - 0.0075 15.5 0.0 0.3 10.3 0.0 2.4 1 1 1 2 2 2 1 KaiC RNA_helicase PF00910.20 001244151.1_49824001_3 - 0.0082 16.4 0.0 0.02 15.2 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_3 PF07726.9 001244151.1_49824001_3 - 0.0085 15.8 0.1 0.12 12.1 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.4 001244151.1_49824001_3 - 0.0085 16.2 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.11 001244151.1_49824001_3 - 0.016 14.0 0.0 0.028 13.2 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus Mg_chelatase PF01078.19 001244151.1_49824001_3 - 0.017 14.4 0.0 0.034 13.4 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.4 001244151.1_49824001_3 - 0.018 14.9 0.0 0.043 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.14 001244151.1_49824001_3 - 0.02 14.2 0.1 0.091 12.1 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein NACHT PF05729.10 001244151.1_49824001_3 - 0.048 13.4 0.1 0.64 9.8 0.0 2.5 2 1 1 3 3 2 0 NACHT domain AAA_11 PF13086.4 001244151.1_49824001_3 - 0.05 13.2 0.3 1.1 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.4 001244151.1_49824001_3 - 0.057 13.0 0.9 0.1 12.1 0.2 1.8 2 1 0 2 2 1 0 AAA domain SKI PF01202.20 001244151.1_49824001_3 - 0.083 12.9 0.0 12 5.8 0.0 2.5 2 0 0 2 2 2 0 Shikimate kinase AAA_30 PF13604.4 001244151.1_49824001_3 - 0.084 12.5 0.2 0.17 11.5 0.2 1.5 1 1 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.15 001244151.1_49824001_3 - 0.13 11.2 0.0 0.25 10.2 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TsaE PF02367.15 001244151.1_49824001_3 - 0.13 12.1 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.16 001244151.1_49824001_3 - 0.14 12.0 0.5 2.1 8.1 0.0 2.7 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea Tmemb_cc2 PF10267.7 001258443.1_49826001_3 - 1.4e-166 554.4 12.9 1.8e-166 554.1 12.9 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein ATF7IP_BD PF16788.3 001258443.1_49826001_3 - 0.0036 17.4 2.5 0.0036 17.4 2.5 2.4 2 0 0 2 2 2 1 ATF-interacting protein binding domain CbiA PF01656.21 001258443.1_49826001_3 - 0.069 13.1 0.1 0.25 11.3 0.0 1.9 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Exonuc_VII_L PF02601.13 001258443.1_49826001_3 - 0.15 11.5 19.2 0.94 8.8 1.2 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Phage_int_SAM_5 PF13102.4 001258443.1_49826001_3 - 1.1 9.3 11.2 3.5 7.7 0.7 2.6 2 0 0 2 2 2 0 Phage integrase SAM-like domain UPF0565 PF10561.7 001258443.1_49826001_3 - 1.5 7.8 8.7 0.085 11.9 0.5 2.5 2 1 0 2 2 2 0 Uncharacterised protein family UPF0565 DUF3453 PF11935.6 001258443.1_49826001_3 - 3.5 7.1 8.2 0.092 12.2 1.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3453) Peptidase_M10 PF00413.22 001099938.1_49823001_1 - 3.2e-60 202.4 0.1 5.3e-60 201.7 0.1 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 001099938.1_49823001_1 - 4.1e-41 138.5 20.0 1.9e-16 59.6 1.2 4.5 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 001099938.1_49823001_1 - 2.8e-13 49.7 0.1 4.9e-13 49.0 0.1 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 001099938.1_49823001_1 - 0.0034 16.9 0.1 1.3 8.4 0.1 2.3 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Metallopep PF12044.6 001099938.1_49823001_1 - 0.014 13.9 0.1 0.022 13.2 0.1 1.2 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M66 PF10462.7 001099938.1_49823001_1 - 0.024 13.5 0.4 0.038 12.8 0.4 1.2 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_3 PF13582.4 001099938.1_49823001_1 - 0.035 14.5 0.1 0.06 13.7 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.9 001099938.1_49823001_1 - 0.064 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M54 Reprolysin_5 PF13688.4 001099938.1_49823001_1 - 0.15 12.1 0.1 0.23 11.4 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 ANAPC8 PF04049.11 001267826.1_49826001_2 - 2.4e-26 92.3 9.3 1.3e-24 86.7 4.1 3.5 2 1 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.26 001267826.1_49826001_2 - 9.7e-24 82.0 31.9 1.2e-05 24.8 0.1 9.8 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_2 PF07719.15 001267826.1_49826001_2 - 8.7e-23 78.4 31.9 0.00093 19.0 0.1 10.5 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_8 PF13181.4 001267826.1_49826001_2 - 3.5e-16 57.9 25.7 0.00017 21.4 0.0 10.1 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_14 PF13428.4 001267826.1_49826001_2 - 2.8e-11 43.1 15.4 0.0084 16.7 0.0 8.4 7 2 3 10 10 10 3 Tetratricopeptide repeat TPR_11 PF13414.4 001267826.1_49826001_2 - 1.3e-10 40.6 11.6 3.4e-06 26.5 0.2 4.9 3 1 1 4 4 4 3 TPR repeat TPR_19 PF14559.4 001267826.1_49826001_2 - 1.4e-09 38.2 17.3 0.0024 18.2 0.1 6.5 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_7 PF13176.4 001267826.1_49826001_2 - 1.7e-07 30.7 19.2 0.87 9.6 0.2 8.7 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_16 PF13432.4 001267826.1_49826001_2 - 1.3e-06 28.8 11.2 0.0044 17.6 0.0 6.4 5 3 1 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.5 001267826.1_49826001_2 - 2.7e-06 27.4 32.6 0.0031 17.5 0.1 6.2 5 1 2 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.4 001267826.1_49826001_2 - 8.8e-06 25.6 14.8 0.17 12.2 0.0 5.9 8 0 0 8 8 6 3 Tetratricopeptide repeat TPR_6 PF13174.4 001267826.1_49826001_2 - 0.00014 22.1 23.1 3.1 8.5 0.0 8.7 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_12 PF13424.4 001267826.1_49826001_2 - 0.0031 17.6 25.1 0.53 10.5 0.1 7.6 5 2 2 8 8 8 3 Tetratricopeptide repeat DUF772 PF05598.9 001267826.1_49826001_2 - 0.0068 16.3 0.1 0.016 15.1 0.1 1.6 1 0 0 1 1 1 1 Transposase domain (DUF772) TPR_10 PF13374.4 001267826.1_49826001_2 - 0.02 14.6 11.3 17 5.3 0.1 6.7 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_9 PF13371.4 001267826.1_49826001_2 - 0.025 14.6 4.8 0.045 13.8 0.2 3.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_15 PF13429.4 001267826.1_49826001_2 - 0.14 11.2 7.6 0.24 10.4 1.7 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat AA_permease_2 PF13520.4 001244165.1_49826001_3 - 5.3e-38 130.8 28.2 5.3e-38 130.8 28.2 2.1 2 0 0 2 2 2 2 Amino acid permease AA_permease PF00324.19 001244165.1_49826001_3 - 5.1e-25 87.9 31.6 5.1e-25 87.9 31.6 2.1 2 0 0 2 2 2 1 Amino acid permease AA_permease_C PF13906.4 001244165.1_49826001_3 - 4e-18 65.1 4.6 4e-18 65.1 4.6 3.6 4 0 0 4 4 4 1 C-terminus of AA_permease PAX PF00292.16 001244172.1_49826001_3 - 1.8e-71 237.8 0.8 2.9e-71 237.1 0.8 1.3 1 0 0 1 1 1 1 'Paired box' domain Homeobox PF00046.27 001244172.1_49826001_3 - 1.3e-22 79.2 4.5 2.5e-22 78.3 4.5 1.5 1 0 0 1 1 1 1 Homeobox domain HTH_32 PF13565.4 001244172.1_49826001_3 - 9.3e-05 22.8 0.9 0.0083 16.6 0.0 3.2 3 0 0 3 3 3 1 Homeodomain-like domain HTH_23 PF13384.4 001244172.1_49826001_3 - 0.0063 16.2 0.0 0.02 14.5 0.0 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_IS1 PF12759.5 001244172.1_49826001_3 - 0.01 15.3 0.0 0.032 13.7 0.0 1.8 2 0 0 2 2 2 1 InsA C-terminal domain SMN PF06003.10 001166309.1_49824001_1 - 4.3e-16 58.8 2.1 6.9e-16 58.2 1.6 1.5 1 1 0 1 1 1 1 Survival motor neuron protein (SMN) TUDOR PF00567.22 001166309.1_49824001_1 - 0.0021 17.9 0.0 0.0053 16.6 0.0 1.7 2 0 0 2 2 2 1 Tudor domain DUF4604 PF15377.4 001244174.1_49822001_1 - 4.4e-29 102.0 13.2 7.1e-29 101.4 13.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Peptidase_S49_N PF08496.8 001244174.1_49822001_1 - 3.6 7.5 7.2 0.68 9.9 0.2 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal PAX PF00292.16 001244178.1_49825001_3 - 4.7e-26 91.0 0.3 8.3e-26 90.2 0.3 1.3 1 0 0 1 1 1 1 'Paired box' domain Homeobox PF00046.27 001244178.1_49825001_3 - 1.2e-22 79.3 4.5 2.3e-22 78.4 4.5 1.5 1 0 0 1 1 1 1 Homeobox domain HTH_Tnp_IS1 PF12759.5 001244178.1_49825001_3 - 0.0013 18.1 0.0 0.0024 17.3 0.0 1.4 1 0 0 1 1 1 1 InsA C-terminal domain ELO PF01151.16 001167634.1_49822001_1 - 2e-67 227.2 21.8 2.5e-67 226.9 21.8 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Peroxin-3 PF04882.10 001244185.1_49824001_1 - 5.2e-66 223.4 6.1 2e-44 152.2 1.0 3.1 1 1 1 2 2 2 2 Peroxin-3 SH3_9 PF14604.4 001244186.1_49824001_2 - 1.5e-16 59.8 0.1 6.7e-16 57.8 0.2 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 001244186.1_49824001_2 - 3.5e-16 58.4 0.1 7e-16 57.4 0.1 1.5 1 0 0 1 1 1 1 SH3 domain FCH PF00611.21 001244186.1_49824001_2 - 2.8e-14 53.0 0.4 2.8e-14 53.0 0.4 2.1 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.15 001244186.1_49824001_2 - 1.4e-11 43.7 0.0 3.8e-11 42.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 001244186.1_49824001_2 - 0.0037 17.4 0.2 0.0067 16.6 0.2 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain DUF2433 PF10360.7 001244186.1_49824001_2 - 0.3 11.0 3.2 0.64 10.0 3.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2433) DUF262 PF03235.12 001244186.1_49824001_2 - 1.3 9.0 6.8 0.85 9.6 5.0 1.5 1 1 1 2 2 2 0 Protein of unknown function DUF262 LBP_BPI_CETP PF01273.23 001101033.1_49824001_3 - 1.3e-06 28.0 1.5 1.4e-06 27.9 0.4 1.6 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain UBA PF00627.29 001267841.1_49826001_3 - 0.0066 16.2 0.2 0.18 11.6 0.0 2.9 3 0 0 3 3 3 1 UBA/TS-N domain MerR-DNA-bind PF09278.9 001267841.1_49826001_3 - 0.11 13.0 0.1 0.39 11.1 0.1 1.9 2 0 0 2 2 2 0 MerR, DNA binding LRR_4 PF12799.5 001097445.2_49824001_2 - 4.5e-08 33.1 2.8 0.018 15.3 0.0 5.3 3 2 4 7 7 7 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001097445.2_49824001_2 - 2e-06 27.3 1.2 0.0062 16.1 0.0 4.1 3 1 1 4 4 4 2 Leucine rich repeat LRR_6 PF13516.4 001097445.2_49824001_2 - 1.3e-05 24.7 5.4 0.85 9.7 0.1 5.5 5 0 0 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.31 001097445.2_49824001_2 - 9.7e-05 22.2 0.6 16 6.3 0.0 5.1 4 1 0 4 4 4 2 Leucine Rich Repeat Toxin_32 PF08120.9 001244203.1_49825001_1 - 0.27 11.0 1.7 0.73 9.6 1.7 1.7 1 0 0 1 1 1 0 Tamulustoxin family BAR PF03114.16 001244203.1_49825001_3 - 1.2e-55 188.7 9.3 1.9e-55 188.0 9.3 1.3 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.4 001244203.1_49825001_3 - 1.2e-07 31.3 0.5 4e-07 29.7 0.1 2.1 2 1 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 001244203.1_49825001_3 - 1.1e-05 24.7 0.0 0.00013 21.3 0.0 2.3 1 1 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001244203.1_49825001_3 - 9.1e-05 21.9 0.0 0.00034 20.1 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain BAR_3 PF16746.3 001244203.1_49825001_3 - 0.02 14.4 10.0 0.012 15.1 6.4 2.0 1 1 1 2 2 2 0 BAR domain of APPL family HD_3 PF13023.4 001244203.1_49825001_3 - 0.022 14.6 4.3 0.085 12.6 0.3 2.4 2 0 0 2 2 2 0 HD domain Lbh PF15317.4 001244203.1_49825001_3 - 0.29 11.9 7.5 0.27 12.0 2.8 2.5 2 0 0 2 2 2 0 Cardiac transcription factor regulator, Developmental protein Jnk-SapK_ap_N PF09744.7 001244203.1_49825001_3 - 0.46 10.6 11.8 0.22 11.6 2.5 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 EzrA PF06160.10 001244203.1_49825001_3 - 0.52 8.3 7.1 1.9 6.4 1.4 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA THP2 PF09432.8 001244203.1_49825001_3 - 0.57 10.1 2.6 0.45 10.4 0.3 1.9 2 0 0 2 2 2 0 Tho complex subunit THP2 DUF3584 PF12128.6 001244203.1_49825001_3 - 0.88 6.9 9.2 2.8 5.2 9.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) OmpH PF03938.12 001244203.1_49825001_3 - 0.89 9.4 12.0 2.8 7.8 0.2 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Thiolase_N PF00108.21 001167638.1_49823001_1 - 3.9e-96 321.3 0.1 6e-96 320.6 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 001167638.1_49823001_1 - 1e-51 173.6 0.1 2.1e-51 172.6 0.1 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.24 001167638.1_49823001_1 - 0.0033 16.9 4.0 0.0045 16.5 0.3 2.7 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain KH_1 PF00013.27 001267845.1_49826001_1 - 2.1e-42 142.6 14.3 1e-19 70.0 1.9 3.3 3 0 0 3 3 3 3 KH domain ROKNT PF08067.9 001267845.1_49826001_1 - 2.9e-26 91.3 9.8 4.9e-26 90.6 9.8 1.4 1 0 0 1 1 1 1 ROKNT (NUC014) domain KH_2 PF07650.15 001267845.1_49826001_1 - 4.1e-13 48.8 6.9 0.0015 18.2 0.4 3.9 3 1 1 4 4 4 3 KH domain KH_4 PF13083.4 001267845.1_49826001_1 - 8.5e-08 31.8 5.2 1.2e-05 24.9 0.0 3.2 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 001267845.1_49826001_1 - 0.00016 21.6 3.1 0.56 10.2 0.1 3.7 3 0 0 3 3 3 2 NusA-like KH domain DJ-1_PfpI PF01965.22 001267845.1_49826001_1 - 0.067 12.9 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family MOEP19 PF16005.3 001267845.1_49826001_1 - 0.074 13.0 0.0 2.9 7.8 0.0 2.4 2 0 0 2 2 2 0 KH-like RNA-binding domain ART PF01129.16 001244205.1_49824001_3 - 5.2e-75 251.4 2.0 7e-75 251.0 2.0 1.2 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Asn_synthase PF00733.19 001167640.1_49824001_1 - 1.6e-84 284.5 0.9 1.5e-47 162.8 0.1 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.4 001167640.1_49824001_1 - 9.1e-26 90.1 0.0 1.6e-25 89.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.4 001167640.1_49824001_1 - 1.3e-19 70.5 0.0 3.3e-19 69.3 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.6 001167640.1_49824001_1 - 9.5e-07 28.3 0.0 1.8e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein tRNA_Me_trans PF03054.14 001167640.1_49824001_1 - 0.0016 17.2 0.0 0.0025 16.5 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase QueC PF06508.11 001167640.1_49824001_1 - 0.026 13.9 0.0 0.051 12.9 0.0 1.5 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC NAD_synthase PF02540.15 001167640.1_49824001_1 - 0.04 12.9 0.0 0.061 12.3 0.0 1.2 1 0 0 1 1 1 0 NAD synthase Cloacin_immun PF03513.12 001167640.1_49824001_1 - 0.076 13.2 0.0 0.24 11.6 0.0 1.8 1 0 0 1 1 1 0 Cloacin immunity protein CDP-OH_P_transf PF01066.19 001167642.1_49822001_1 - 1.7e-12 47.8 1.5 1.7e-12 47.8 1.5 2.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase EBP PF05241.10 001167646.1_49822001_1 - 2.3e-57 193.2 8.3 2.8e-57 192.9 8.3 1.1 1 0 0 1 1 1 1 Emopamil binding protein Phage_holin_3_6 PF07332.9 001167646.1_49822001_1 - 1.2 9.1 7.7 2.1 8.3 0.1 2.3 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III COMM_domain PF07258.12 001267850.1_49824001_3 - 6.4e-16 58.1 0.0 9.5e-16 57.5 0.0 1.3 1 0 0 1 1 1 1 COMM domain SQS_PSY PF00494.17 001167648.1_49823001_1 - 3.5e-38 131.5 0.0 4.7e-38 131.1 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase Octopine_DH PF02317.15 001167648.1_49823001_1 - 0.012 15.6 0.1 0.03 14.3 0.0 1.7 2 0 0 2 2 2 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain Na_H_Exchanger PF00999.19 001267851.1_49826001_3 - 4.3e-68 229.7 40.5 5.4e-68 229.4 40.5 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF16 PF01519.14 001267851.1_49826001_3 - 2.1 8.7 4.7 4 7.8 4.7 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 Peptidase_S46 PF10459.7 001267851.1_49826001_3 - 7.2 5.0 7.6 9.9 4.5 7.6 1.1 1 0 0 1 1 1 0 Peptidase S46 Resistin PF06954.9 001103210.1_49821001_2 - 9.8e-37 125.3 14.3 1.2e-36 125.0 14.3 1.1 1 0 0 1 1 1 1 Resistin PX PF00787.22 001244216.1_49827001_2 - 1.6e-19 69.8 0.2 9.4e-19 67.3 0.2 2.1 2 0 0 2 2 2 1 PX domain Vps5 PF09325.8 001244216.1_49827001_2 - 5e-15 55.6 11.8 3.5e-10 39.7 4.9 2.3 1 1 1 2 2 2 2 Vps5 C terminal like BAR PF03114.16 001244216.1_49827001_2 - 1.1e-06 28.3 13.9 9e-05 22.1 9.4 2.4 2 0 0 2 2 2 2 BAR domain Stanniocalcin PF03298.11 001103212.1_49822001_3 - 8.8e-101 335.2 7.8 1.1e-100 334.9 7.8 1.1 1 0 0 1 1 1 1 Stanniocalcin family SAM_1 PF00536.28 001244218.1_49824001_2 - 2.6e-09 37.2 0.0 4.8e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-C3HC4_4 PF15227.4 001244218.1_49824001_2 - 1.7e-08 34.3 12.2 2.9e-08 33.6 12.2 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001244218.1_49824001_2 - 4.9e-08 32.6 13.7 7.9e-08 31.9 13.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001244218.1_49824001_2 - 8.3e-08 31.8 13.3 1.4e-07 31.1 13.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001244218.1_49824001_2 - 6.1e-06 25.9 7.9 9e-06 25.3 7.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SAM_2 PF07647.15 001244218.1_49824001_2 - 8.2e-06 25.7 0.0 1.7e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-RING_2 PF13639.4 001244218.1_49824001_2 - 2.3e-05 24.4 14.8 4.3e-05 23.6 14.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.4 001244218.1_49824001_2 - 2.6e-05 24.0 13.0 6e-05 22.8 13.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger SAM_PNT PF02198.14 001244218.1_49824001_2 - 0.0056 16.5 0.1 0.013 15.4 0.1 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain zf-ANAPC11 PF12861.5 001244218.1_49824001_2 - 0.011 15.7 4.2 0.028 14.3 4.2 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.3 001244218.1_49824001_2 - 0.015 15.3 6.2 0.025 14.6 6.2 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_5 PF14634.4 001244218.1_49824001_2 - 0.032 14.1 11.5 0.057 13.3 11.5 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-rbx1 PF12678.5 001244218.1_49824001_2 - 0.035 14.3 10.3 0.073 13.2 10.3 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.4 001244218.1_49824001_2 - 0.19 11.5 10.2 0.37 10.6 10.2 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.4 001244218.1_49824001_2 - 2.8 7.6 13.6 0.023 14.3 4.5 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Urocanase PF01175.16 001244219.1_49826001_1 - 5.2e-246 817.0 0.5 6.4e-246 816.7 0.5 1.0 1 0 0 1 1 1 1 Urocanase E1_DerP2_DerF2 PF02221.13 001104956.1_49822001_3 - 9.9e-17 61.5 0.0 1.2e-16 61.2 0.0 1.1 1 0 0 1 1 1 1 ML domain RGCC PF15151.4 001244227.1_49822001_3 - 2.9e-65 218.5 2.5 3.8e-65 218.1 2.5 1.1 1 0 0 1 1 1 1 Response gene to complement 32 protein family TRAM_LAG1_CLN8 PF03798.14 001167631.1_49823001_1 - 6.8e-39 133.5 23.6 8.7e-39 133.2 23.6 1.1 1 0 0 1 1 1 1 TLC domain Homeobox PF00046.27 001167631.1_49823001_1 - 6.1e-07 29.0 0.9 9.6e-07 28.4 0.9 1.3 1 0 0 1 1 1 1 Homeobox domain 3Beta_HSD PF01073.17 001167636.1_49823001_1 - 2.7e-63 213.5 0.0 3.5e-63 213.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 001167636.1_49823001_1 - 2.8e-35 121.8 0.0 3.6e-35 121.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 001167636.1_49823001_1 - 9.7e-20 71.1 0.0 2.3e-17 63.2 0.0 2.6 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.4 001167636.1_49823001_1 - 2.8e-16 59.9 0.0 3.7e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 001167636.1_49823001_1 - 5.1e-11 42.1 0.0 7e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.10 001167636.1_49823001_1 - 1.3e-09 37.5 0.0 9.5e-05 21.5 0.0 2.5 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.13 001167636.1_49823001_1 - 4.9e-08 32.3 0.0 1.3e-06 27.7 0.0 2.6 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.11 001167636.1_49823001_1 - 7.7e-05 22.2 0.0 0.00013 21.4 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family NAD_binding_2 PF03446.13 001167636.1_49823001_1 - 0.031 14.3 0.0 0.062 13.3 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_7 PF13241.4 001167636.1_49823001_1 - 0.049 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding KR PF08659.8 001167636.1_49823001_1 - 0.097 12.4 0.1 1.7 8.4 0.0 2.2 1 1 0 2 2 2 0 KR domain TGFb_propeptide PF00688.16 001168001.1_49824001_3 - 8.9e-97 323.5 0.0 1.2e-96 323.1 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001168001.1_49824001_3 - 1.5e-37 128.5 1.1 3.2e-37 127.5 1.1 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain Proteasome PF00227.24 001139472.2_49823001_1 - 1.4e-53 181.1 0.1 1.8e-53 180.7 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 001139472.2_49823001_1 - 2.4e-14 52.5 0.0 4.3e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature COX6B PF02297.15 001097497.2_49822001_3 - 6.1e-17 61.5 3.5 8.6e-17 61.0 3.5 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Pkinase_Tyr PF07714.15 001244239.1_49825001_2 - 1.1e-24 87.0 0.6 2e-24 86.2 0.6 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001244239.1_49825001_2 - 2e-24 86.3 1.5 4.5e-24 85.1 1.5 1.6 1 1 0 1 1 1 1 Protein kinase domain Ras PF00071.20 001168417.1_49822001_1 - 8.8e-48 161.8 0.0 1e-47 161.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001168417.1_49822001_1 - 1.7e-18 66.9 0.0 2.4e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001168417.1_49822001_1 - 3.8e-05 23.1 0.0 5.1e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family TniB PF05621.9 001168417.1_49822001_1 - 0.028 13.5 0.0 0.046 12.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein GTP_EFTU PF00009.25 001168417.1_49822001_1 - 0.073 12.5 0.0 3.3 7.1 0.0 2.4 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain 7tm_1 PF00001.19 001044624.2_49823001_3 - 8.4e-48 162.8 6.7 1.1e-47 162.4 6.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001044624.2_49823001_3 - 6.1e-07 28.9 0.5 8.7e-07 28.4 0.5 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001044624.2_49823001_3 - 3.7e-06 26.7 1.0 5.5e-06 26.2 1.0 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001044624.2_49823001_3 - 0.051 12.7 3.8 0.084 12.0 3.8 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx SWIB PF02201.16 001244252.1_49826001_2 - 1.3e-18 66.5 0.0 2.4e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain JAB PF01398.19 001105300.1_49823001_1 - 7.8e-34 116.0 0.9 1e-33 115.6 0.0 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.4 001105300.1_49823001_1 - 0.00019 21.0 0.0 0.00032 20.3 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.11 001105300.1_49823001_1 - 0.0052 16.7 0.0 0.012 15.5 0.0 1.7 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) 7tm_1 PF00001.19 001244253.1_49825001_3 - 1.4e-86 289.9 9.6 1.9e-86 289.5 9.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001244253.1_49825001_3 - 1.7e-16 60.3 23.6 3.2e-13 49.5 16.0 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001244253.1_49825001_3 - 1.5e-05 24.4 17.9 1.5e-05 24.4 17.9 2.1 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.7 001244253.1_49825001_3 - 0.00013 21.3 25.4 0.013 14.8 18.4 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001244253.1_49825001_3 - 0.00065 19.4 12.6 0.00065 19.4 12.6 2.1 2 0 0 2 2 2 1 Olfactory receptor Rifin_STEVOR PF02009.14 001244253.1_49825001_3 - 0.061 13.1 1.1 0.11 12.3 1.1 1.3 1 0 0 1 1 1 0 Rifin/stevor family DUF912 PF06024.10 001244253.1_49825001_3 - 0.35 11.0 4.2 4.8 7.4 0.6 3.2 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF1230 PF06799.9 001244253.1_49825001_3 - 2.6 8.0 6.3 3.6 7.6 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1230) DUF2207 PF09972.7 001244253.1_49825001_3 - 4.5 5.8 10.2 39 2.7 0.1 2.9 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) COX8 PF02285.13 001097500.2_49821001_3 - 1.7e-23 82.0 0.1 3.3e-23 81.1 0.1 1.5 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIII FAP PF07174.9 001097500.2_49821001_3 - 0.058 12.7 0.0 0.066 12.5 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Ras PF00071.20 001244254.1_49824001_1 - 5.1e-62 208.1 0.6 1.2e-61 206.9 0.4 1.6 2 0 0 2 2 2 1 Ras family Roc PF08477.11 001244254.1_49824001_1 - 2.5e-35 121.2 0.2 1.3e-34 118.9 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001244254.1_49824001_1 - 7.1e-12 45.0 0.0 9.8e-12 44.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001244254.1_49824001_1 - 0.0002 20.7 0.0 0.00026 20.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001244254.1_49824001_1 - 0.00057 19.8 0.0 0.00087 19.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001244254.1_49824001_1 - 0.0041 16.9 0.8 1.2 8.9 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001244254.1_49824001_1 - 0.0071 15.8 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.4 001244254.1_49824001_1 - 0.1 12.8 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain PI31_Prot_N PF11566.6 001171751.1_49824001_1 - 9e-18 64.4 0.0 1.8e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal F-box-like PF12937.5 001171751.1_49824001_1 - 3.2e-09 36.4 5.5 6.4e-09 35.4 5.5 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001171751.1_49824001_1 - 1.2e-05 24.9 3.4 2.6e-05 23.9 3.4 1.6 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.9 001171751.1_49824001_1 - 0.00065 20.0 0.2 0.0015 18.9 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A YukD PF08817.8 001171751.1_49824001_1 - 0.13 12.9 0.0 0.26 11.9 0.0 1.5 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD Kelch_6 PF13964.4 001105314.1_49823001_1 - 1.2e-46 155.4 8.3 5.2e-08 32.8 0.0 6.3 5 1 1 6 6 6 6 Kelch motif Kelch_1 PF01344.23 001105314.1_49823001_1 - 1.2e-41 139.9 6.7 3.2e-07 29.7 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_2 PF07646.13 001105314.1_49823001_1 - 2.9e-41 137.8 11.9 1.8e-09 37.1 0.1 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.4 001105314.1_49823001_1 - 2.2e-32 110.6 13.7 4.5e-08 32.8 0.3 7.2 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.4 001105314.1_49823001_1 - 3.2e-32 109.8 13.3 2.4e-06 27.2 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.4 001105314.1_49823001_1 - 3.7e-32 109.8 13.1 1.3e-06 28.4 0.5 7.2 7 0 0 7 7 7 5 Galactose oxidase, central domain CRAL_TRIO PF00650.18 001195355.1_49825001_1 - 1.9e-26 92.5 0.6 4e-26 91.5 0.6 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain Motile_Sperm PF00635.24 001195355.1_49825001_1 - 1.2e-21 76.5 0.0 2.4e-21 75.5 0.0 1.6 1 0 0 1 1 1 1 MSP (Major sperm protein) domain CRAL_TRIO_2 PF13716.4 001195355.1_49825001_1 - 0.0016 18.4 0.3 0.0034 17.4 0.3 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain PID PF00640.21 001195355.1_49825001_1 - 0.032 14.1 0.0 0.066 13.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) SIR2 PF02146.15 001110057.1_49823001_2 - 1e-52 178.5 0.0 1.3e-52 178.2 0.0 1.1 1 0 0 1 1 1 1 Sir2 family CutC PF03932.12 001110057.1_49823001_2 - 0.12 11.7 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 CutC family CD225 PF04505.10 001110058.1_49822001_1 - 1.7e-21 76.0 0.5 3e-21 75.2 0.5 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein DUF4190 PF13828.4 001110058.1_49822001_1 - 0.0058 16.2 2.9 0.033 13.8 2.9 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4190) DsbD PF02683.13 001110058.1_49822001_1 - 0.028 14.2 0.8 0.038 13.7 0.8 1.2 1 0 0 1 1 1 0 Cytochrome C biogenesis protein transmembrane region THUMP PF02926.15 001244282.1_49828001_1 - 2.2e-23 82.8 0.5 3.8e-23 82.0 0.5 1.3 1 0 0 1 1 1 1 THUMP domain Trypsin_2 PF13365.4 001195343.1_49823001_1 - 3.7e-30 105.6 0.1 6.7e-30 104.8 0.1 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.24 001195343.1_49823001_1 - 6.5e-15 55.4 0.0 9.5e-15 54.9 0.0 1.2 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.4 001195343.1_49823001_1 - 1.9e-11 43.9 0.1 7.3e-11 42.1 0.0 2.0 2 0 0 2 2 2 1 PDZ domain Kazal_2 PF07648.13 001195343.1_49823001_1 - 8.3e-10 38.6 0.8 1.6e-09 37.7 0.8 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain PDZ PF00595.22 001195343.1_49823001_1 - 1.5e-09 37.9 0.0 3.7e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) IGFBP PF00219.16 001195343.1_49823001_1 - 1.2e-08 35.3 21.2 1.2e-08 35.3 21.2 2.1 2 0 0 2 2 2 1 Insulin-like growth factor binding protein Peptidase_S46 PF10459.7 001195343.1_49823001_1 - 0.00015 20.4 1.4 0.091 11.3 0.1 2.1 2 0 0 2 2 2 2 Peptidase S46 Kazal_1 PF00050.19 001195343.1_49823001_1 - 0.00018 21.3 3.2 0.00018 21.3 3.2 2.0 2 0 0 2 2 1 1 Kazal-type serine protease inhibitor domain Peptidase_S32 PF05579.11 001195343.1_49823001_1 - 0.0015 17.7 0.1 1.2 8.1 0.0 2.1 2 0 0 2 2 2 2 Equine arteritis virus serine endopeptidase S32 DUF31 PF01732.14 001195343.1_49823001_1 - 0.073 12.5 0.3 8.9 5.6 0.1 2.1 2 0 0 2 2 2 0 Putative peptidase (DUF31) Tricorn_PDZ PF14685.4 001195343.1_49823001_1 - 0.1 12.5 0.1 0.33 10.8 0.1 1.8 2 0 0 2 2 2 0 Tricorn protease PDZ domain Motile_Sperm PF00635.24 001195356.1_49822001_1 - 3.4e-14 52.5 0.0 5e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Sulfotransfer_3 PF13469.4 001244291.1_49824001_1 - 1.1e-55 189.2 0.0 1.6e-55 188.7 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.25 001244291.1_49824001_1 - 1.1e-08 34.7 0.1 4.4e-08 32.8 0.1 1.9 1 1 0 1 1 1 1 Sulfotransferase domain Proteasome PF00227.24 001144926.2_49822001_2 - 9.8e-46 155.5 0.3 1.2e-45 155.2 0.3 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF1502 PF07397.9 001144926.2_49822001_2 - 0.022 14.5 1.0 0.048 13.4 1.0 1.5 1 0 0 1 1 1 0 Repeat of unknown function (DUF1502) HEAT PF02985.20 001244301.1_49827001_1 - 6.7e-22 75.5 2.2 5.5e-05 22.9 0.0 9.5 11 0 0 11 11 9 3 HEAT repeat HEAT_2 PF13646.4 001244301.1_49827001_1 - 5.6e-21 74.6 0.4 8.5e-09 35.5 0.0 7.6 5 3 3 8 8 8 3 HEAT repeats HEAT_EZ PF13513.4 001244301.1_49827001_1 - 1.1e-18 67.1 3.9 6.4e-08 32.8 0.0 8.1 8 2 2 10 10 9 3 HEAT-like repeat Vac14_Fab1_bd PF12755.5 001244301.1_49827001_1 - 1.8e-17 63.6 6.9 2.4e-06 27.9 0.0 8.4 6 2 1 8 8 8 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.5 001244301.1_49827001_1 - 4e-08 33.3 3.8 7.7e-05 22.6 0.1 4.0 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.6 001244301.1_49827001_1 - 1.6e-06 27.9 10.2 2.2 8.0 0.0 8.4 7 2 3 10 10 10 2 Domain of unknown function (DUF3385) Arm PF00514.21 001244301.1_49827001_1 - 0.00024 20.9 0.4 21 5.2 0.0 5.6 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat IBN_N PF03810.17 001244301.1_49827001_1 - 0.00024 20.8 2.6 0.0012 18.6 0.1 3.6 4 0 0 4 4 4 1 Importin-beta N-terminal domain RTP1_C1 PF10363.7 001244301.1_49827001_1 - 0.0015 18.5 0.1 0.71 9.9 0.0 4.3 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_PBS PF03130.14 001244301.1_49827001_1 - 0.0031 17.9 1.3 1.6 9.5 0.0 4.5 5 0 0 5 5 3 1 PBS lyase HEAT-like repeat AAA_30 PF13604.4 001244301.1_49827001_1 - 0.03 13.9 3.3 3.1 7.4 0.1 3.6 3 1 0 3 3 3 0 AAA domain PBP1_TM PF14812.4 001244301.1_49827001_1 - 0.056 13.8 0.2 0.056 13.8 0.2 2.1 2 0 0 2 2 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Atx10homo_assoc PF09759.7 001244301.1_49827001_1 - 0.19 11.7 1.1 19 5.3 0.0 4.3 4 0 0 4 4 4 0 Spinocerebellar ataxia type 10 protein domain Lectin_C PF00059.19 001112678.1_49823001_2 - 1.9e-24 86.3 3.7 5e-24 85.0 3.7 1.7 1 0 0 1 1 1 1 Lectin C-type domain Sushi PF00084.18 001112678.1_49823001_2 - 1.2e-09 38.5 20.2 1.6e-05 25.3 4.0 3.2 2 1 1 3 3 3 2 Sushi repeat (SCR repeat) EGF PF00008.25 001112678.1_49823001_2 - 7.1e-05 22.9 11.5 8.2e-05 22.7 8.4 2.9 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.5 001112678.1_49823001_2 - 0.00043 20.7 7.3 0.004 17.7 7.3 2.9 1 0 0 1 1 1 1 Human growth factor-like EGF EGF_2 PF07974.11 001112678.1_49823001_2 - 0.00054 20.1 12.4 0.00054 20.1 12.4 3.1 2 0 0 2 2 2 1 EGF-like domain Plasmod_Pvs28 PF06247.9 001112678.1_49823001_2 - 0.0057 16.8 5.5 0.017 15.2 5.5 1.8 1 0 0 1 1 1 1 Pvs28 EGF domain CHD5 PF04420.12 001244308.1_49822001_3 - 2.7e-33 115.0 1.0 3.3e-33 114.7 1.0 1.1 1 0 0 1 1 1 1 CHD5-like protein DUF2203 PF09969.7 001244308.1_49822001_3 - 0.00087 19.9 0.5 0.058 14.0 0.1 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2203) DUF1043 PF06295.10 001244308.1_49822001_3 - 0.0019 18.1 1.5 0.0028 17.5 1.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) DUF2868 PF11067.6 001244308.1_49822001_3 - 0.0091 15.4 0.2 0.13 11.6 0.2 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2868) DUF4781 PF16013.3 001244308.1_49822001_3 - 0.021 13.5 0.0 0.031 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) DUF1640 PF07798.9 001244308.1_49822001_3 - 0.55 10.1 6.2 1.2 9.1 6.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) MCU PF04678.11 001244308.1_49822001_3 - 0.86 9.6 6.6 4.5 7.3 6.5 1.9 1 1 0 1 1 1 0 Mitochondrial calcium uniporter C1q PF00386.19 001112680.1_49824001_2 - 1e-24 87.0 0.0 1.5e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 C1q domain Transketolase_N PF00456.19 001112681.1_49825001_2 - 6.1e-44 150.2 0.0 1.1e-43 149.4 0.0 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.22 001112681.1_49825001_2 - 4.1e-41 140.5 0.0 8e-41 139.5 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.18 001112681.1_49825001_2 - 5e-33 113.5 0.4 8.9e-33 112.7 0.4 1.4 1 0 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.18 001112681.1_49825001_2 - 7.5e-08 31.5 0.0 1.3e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.4 001112681.1_49825001_2 - 1.7e-06 27.4 0.0 0.00015 20.9 0.0 2.7 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.19 001112681.1_49825001_2 - 0.00029 20.5 0.2 0.0021 17.7 0.2 2.4 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain XFP_N PF09364.8 001112681.1_49825001_2 - 0.00045 19.0 0.0 0.00089 18.0 0.0 1.4 1 1 0 1 1 1 1 XFP N-terminal domain PHD PF00628.27 001244314.1_49824001_3 - 2.6e-07 30.3 6.4 4.7e-07 29.5 6.4 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.4 001244314.1_49824001_3 - 3.1e-06 26.5 2.1 6.1e-06 25.5 2.1 1.5 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.20 001244314.1_49824001_3 - 0.0086 15.8 0.6 0.0086 15.8 0.6 2.0 1 1 1 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Nha1_C PF08619.8 001244314.1_49824001_3 - 0.2 10.7 9.4 0.42 9.6 9.4 1.4 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Pox_Ag35 PF03286.12 001244314.1_49824001_3 - 0.77 9.4 7.1 0.088 12.5 2.7 1.6 2 0 0 2 2 2 0 Pox virus Ag35 surface protein MIP PF00230.18 001112684.1_49822001_2 - 2.8e-54 184.1 14.5 3.5e-54 183.8 14.5 1.0 1 0 0 1 1 1 1 Major intrinsic protein DUF3522 PF12036.6 001112684.1_49822001_2 - 0.0044 17.3 1.2 0.0049 17.1 0.3 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3522) S1FA PF04689.11 001112686.1_49823001_2 - 0.24 11.5 1.6 0.39 10.8 1.6 1.3 1 0 0 1 1 1 0 DNA binding protein S1FA LIM PF00412.20 001112686.1_49823001_3 - 2.4e-30 104.4 16.3 5.3e-16 58.5 1.2 2.7 3 0 0 3 3 3 2 LIM domain HIT PF01230.21 001244325.1_49822001_1 - 8e-27 93.7 0.0 1.1e-26 93.3 0.0 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.6 001244325.1_49822001_1 - 1.9e-21 76.5 0.0 2.4e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Sensor PF13796.4 001244325.1_49822001_1 - 0.03 14.2 0.4 0.05 13.5 0.4 1.3 1 0 0 1 1 1 0 Putative sensor UPF0542 PF15086.4 001195320.1_49823001_2 - 0.073 12.9 7.1 0.11 12.3 7.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 OAD_gamma PF04277.11 001195320.1_49823001_2 - 7.5 7.1 9.4 11 6.6 9.4 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain GETHR PF05671.9 001195320.1_49823001_3 - 0.18 11.0 1.3 4.5 6.6 0.0 3.1 3 0 0 3 3 3 0 GETHR pentapeptide repeat (5 copies) DUF4723 PF15851.3 001195320.1_49823001_3 - 0.8 9.7 9.5 1.3 9.1 9.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4723) Activin_recp PF01064.21 001195320.1_49823001_3 - 2.9 8.9 13.3 7.8 7.5 13.3 1.7 1 1 0 1 1 1 0 Activin types I and II receptor domain FA_desaturase PF00487.22 001113041.1_49823001_1 - 2.3e-30 106.1 30.7 2.3e-30 106.1 30.7 1.8 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.26 001113041.1_49823001_1 - 4.3e-20 71.5 0.0 1.3e-19 69.9 0.0 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DED PF01335.19 001113041.1_49823001_1 - 0.047 13.8 0.2 0.099 12.8 0.2 1.4 1 0 0 1 1 1 0 Death effector domain IlvGEDA_leader PF08046.9 001113041.1_49823001_3 - 5.1 6.5 5.1 33 3.9 0.0 3.4 3 0 0 3 3 3 0 IlvGEDA operon leader peptide Neuromodulin PF06614.9 001244335.1_49824001_1 - 2.7e-77 258.7 68.6 2.7e-77 258.7 68.6 2.0 1 1 1 2 2 2 1 Neuromodulin Neuromodulin_N PF10580.7 001244335.1_49824001_1 - 3.7e-18 64.8 6.2 3.7e-18 64.8 6.2 2.8 3 0 0 3 3 3 1 Gap junction protein N-terminal region IQ PF00612.25 001244335.1_49824001_1 - 2.8e-06 26.5 2.7 5.5e-06 25.6 0.4 2.4 2 0 0 2 2 2 1 IQ calmodulin-binding motif UPF0121 PF03661.11 001244343.1_49825001_3 - 3.2e-95 317.9 12.2 4.5e-95 317.4 12.2 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Lectin_C PF00059.19 214091.2_49822001_1 - 3.6e-12 46.8 5.5 6.2e-12 46.1 5.5 1.4 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 214091.2_49822001_1 - 0.00024 20.7 3.1 0.00062 19.3 3.1 1.8 1 1 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like ADP_ribosyl_GH PF03747.12 001244347.1_49825001_2 - 9.3e-57 192.8 2.7 1.4e-56 192.2 2.7 1.3 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Thioredoxin PF00085.18 001195372.1_49821001_1 - 2.8e-22 78.5 0.0 3.5e-22 78.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.4 001195372.1_49821001_1 - 2.3e-06 27.7 0.1 4.4e-05 23.6 0.0 2.0 1 1 1 2 2 2 1 Thioredoxin-like OST3_OST6 PF04756.11 001195372.1_49821001_1 - 5.3e-06 25.9 0.1 6.4e-06 25.6 0.1 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.4 001195372.1_49821001_1 - 2e-05 24.2 0.0 2.4e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.4 001195372.1_49821001_1 - 6e-05 23.3 0.1 0.0002 21.6 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.19 001195372.1_49821001_1 - 0.00048 19.9 0.0 0.00065 19.5 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.4 001195372.1_49821001_1 - 0.0015 18.6 0.0 0.0021 18.1 0.0 1.3 1 1 0 1 1 1 1 Thioredoxin-like Glutaredoxin PF00462.22 001195372.1_49821001_1 - 0.0085 16.2 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin DIM1 PF02966.14 001195372.1_49821001_1 - 0.021 14.5 0.2 0.023 14.3 0.2 1.1 1 0 0 1 1 1 0 Mitosis protein DIM1 Redoxin PF08534.8 001195372.1_49821001_1 - 0.12 11.9 0.2 0.23 11.0 0.1 1.5 1 1 0 1 1 1 0 Redoxin Smoothelin PF12510.6 001244360.1_49827001_3 - 3e-45 151.9 32.4 5.3e-20 71.1 5.8 3.6 3 0 0 3 3 3 3 Smoothelin cytoskeleton protein CH PF00307.29 001244360.1_49827001_3 - 4.7e-24 84.5 0.0 4.1e-22 78.3 0.0 2.4 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001244360.1_49827001_3 - 2e-05 24.2 0.0 3.8e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain Peptidase_M3_N PF08439.8 001244360.1_49827001_3 - 0.18 12.0 9.0 3.2 8.0 1.3 2.6 2 0 0 2 2 2 0 Oligopeptidase F DCP1 PF06058.11 001244358.1_49824001_2 - 1.8e-41 140.6 0.0 4e-41 139.5 0.0 1.6 1 0 0 1 1 1 1 Dcp1-like decapping family mRNA_decap_C PF16741.3 001244358.1_49824001_2 - 2.5e-20 71.4 4.9 5.1e-20 70.4 4.9 1.6 1 0 0 1 1 1 1 mRNA-decapping enzyme C-terminus WH1 PF00568.21 001244358.1_49824001_2 - 0.15 11.9 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 WH1 domain HEM4 PF02602.13 001244366.1_49824001_3 - 4.1e-43 147.3 0.0 5.5e-43 146.8 0.0 1.2 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Rotamase PF00639.19 001244371.1_49823001_2 - 3.1e-23 82.4 0.0 4.6e-23 81.9 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.4 001244371.1_49823001_2 - 1.5e-20 73.8 0.0 2.1e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.24 001244371.1_49823001_2 - 8.4e-15 54.3 0.1 1.6e-14 53.4 0.1 1.5 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.4 001244371.1_49823001_2 - 0.0018 19.0 0.0 0.0027 18.5 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Ribosomal_L17 PF01196.17 001244380.1_49822001_1 - 1.4e-23 83.4 0.0 2.1e-23 82.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L17 DUF4186 PF13811.4 001244380.1_49822001_2 - 2.5 8.1 6.8 0.4 10.6 1.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4186) fn3 PF00041.19 001146128.2_49824001_1 - 5.1e-08 33.0 0.1 9.6e-08 32.1 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III domain Kelch_3 PF13415.4 001244400.1_49823001_3 - 1.4e-36 124.0 10.9 1.9e-07 31.0 0.0 6.9 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_4 PF13418.4 001244400.1_49823001_3 - 4.2e-35 119.3 3.7 1.2e-07 31.4 0.0 6.6 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.13 001244400.1_49823001_3 - 6.5e-32 108.2 4.5 5e-16 57.8 0.1 6.4 5 1 0 5 5 5 5 Kelch motif Kelch_6 PF13964.4 001244400.1_49823001_3 - 5.3e-30 102.6 7.2 7.2e-06 26.0 0.0 5.9 2 1 4 6 6 6 5 Kelch motif Kelch_1 PF01344.23 001244400.1_49823001_3 - 3e-28 97.0 2.3 2.7e-06 26.7 0.0 6.4 7 0 0 7 7 7 5 Kelch motif Kelch_5 PF13854.4 001244400.1_49823001_3 - 1.8e-27 94.7 8.3 8e-06 25.6 0.0 7.1 7 0 0 7 7 7 6 Kelch motif IFNGR1 PF07140.9 001177907.1_49825001_1 - 1.8e-36 125.1 4.7 3.3e-36 124.2 4.7 1.3 1 0 0 1 1 1 1 Interferon gamma receptor (IFNGR1) Tissue_fac PF01108.15 001177907.1_49825001_1 - 1e-13 50.9 0.4 1e-13 50.9 0.4 2.0 2 0 0 2 2 2 1 Tissue factor Interfer-bind PF09294.8 001177907.1_49825001_1 - 1.4e-08 34.9 0.1 3.3e-08 33.6 0.1 1.7 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III Comm PF15957.3 001177907.1_49825001_1 - 0.00032 20.9 0.0 0.00077 19.7 0.0 1.6 1 0 0 1 1 1 1 Commissureless SIR2 PF02146.15 001114271.1_49824001_1 - 4.3e-56 189.5 0.0 5.7e-56 189.1 0.0 1.1 1 0 0 1 1 1 1 Sir2 family YdjO PF14169.4 001114271.1_49824001_1 - 0.0029 17.2 0.1 0.0067 16.0 0.1 1.5 1 0 0 1 1 1 1 Cold-inducible protein YdjO SR-25 PF10500.7 001114271.1_49824001_1 - 2.1 7.8 16.0 1.5 8.3 14.3 1.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SIR2 PF02146.15 001114273.1_49823001_1 - 1.8e-25 89.8 0.0 1.5e-17 64.0 0.0 2.1 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.20 001114273.1_49823001_1 - 0.00033 20.3 0.0 0.0026 17.4 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain S_100 PF01023.17 001177906.1_49822001_3 - 3.6e-21 74.5 1.1 8.7e-21 73.2 0.2 2.0 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 001177906.1_49822001_3 - 0.00035 20.9 0.2 0.0005 20.3 0.2 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001177906.1_49822001_3 - 0.0012 18.1 0.3 0.035 13.5 0.1 2.3 2 0 0 2 2 2 1 EF hand PRP9_N PF16958.3 001177906.1_49822001_3 - 0.028 14.3 1.2 0.037 13.9 1.2 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor PRP9 N-terminus SPARC_Ca_bdg PF10591.7 001177906.1_49822001_3 - 0.05 13.8 1.5 0.078 13.2 1.5 1.4 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Sad1_UNC PF07738.11 001177910.1_49823001_1 - 3.8e-40 136.9 0.0 6e-40 136.2 0.0 1.3 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal RRF PF01765.17 001177910.1_49823001_1 - 0.073 12.9 0.2 0.12 12.2 0.2 1.3 1 0 0 1 1 1 0 Ribosome recycling factor THOC7 PF05615.11 001177910.1_49823001_1 - 0.1 12.8 0.9 0.17 12.1 0.9 1.2 1 0 0 1 1 1 0 Tho complex subunit 7 Ribosomal_S14 PF00253.19 001244412.1_49824001_2 - 9.5 5.9 8.8 3.2 7.5 4.9 2.2 2 0 0 2 2 2 0 Ribosomal protein S14p/S29e Heme_oxygenase PF01126.18 001244412.1_49824001_3 - 2.3e-80 269.1 8.1 2.6e-80 268.9 7.4 1.4 2 0 0 2 2 2 1 Heme oxygenase SsgA PF04686.10 001244412.1_49824001_3 - 0.021 14.7 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 Streptomyces sporulation and cell division protein, SsgA DUF349 PF03993.10 001244412.1_49824001_3 - 0.14 12.3 1.9 0.76 10.0 0.9 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) SPATA19 PF15212.4 001177920.1_49822001_2 - 4.6e-74 246.7 10.0 5.6e-74 246.4 10.0 1.1 1 0 0 1 1 1 1 Spermatogenesis-associated protein 19, mitochondrial NCOA_u2 PF16665.3 001114276.1_49829001_2 - 3.8e-44 149.6 19.8 3.8e-44 149.6 19.8 6.5 6 1 1 7 7 4 1 Unstructured region on nuclear receptor coactivator protein PAS_11 PF14598.4 001114276.1_49829001_2 - 6.5e-37 126.0 0.6 6.5e-33 113.1 0.1 2.6 2 0 0 2 2 2 2 PAS domain DUF4927 PF16279.3 001114276.1_49829001_2 - 3.4e-34 117.6 6.7 1.2e-33 115.8 6.7 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4927) SRC-1 PF08832.8 001114276.1_49829001_2 - 4.2e-29 101.3 5.1 4.2e-29 101.3 5.1 4.8 6 0 0 6 6 5 1 Steroid receptor coactivator DUF1518 PF07469.10 001114276.1_49829001_2 - 4.4e-25 87.7 23.2 4.4e-25 87.7 23.2 7.1 7 1 1 8 8 4 1 Domain of unknown function (DUF1518) Nuc_rec_co-act PF08815.8 001114276.1_49829001_2 - 7.5e-25 86.4 2.5 1.6e-24 85.4 2.5 1.6 1 0 0 1 1 1 1 Nuclear receptor coactivator PAS PF00989.23 001114276.1_49829001_2 - 7.8e-08 32.2 0.0 2.9e-07 30.3 0.0 2.0 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.10 001114276.1_49829001_2 - 5e-06 26.6 0.2 0.00025 21.1 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.5 001114276.1_49829001_2 - 0.0001 22.4 0.1 0.00024 21.2 0.1 1.6 1 0 0 1 1 1 1 PAS domain HLH PF00010.24 001114276.1_49829001_2 - 0.015 15.1 0.2 0.042 13.7 0.2 1.8 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain PAS_4 PF08448.8 001114276.1_49829001_2 - 0.068 13.3 0.0 0.17 12.0 0.0 1.7 1 0 0 1 1 1 0 PAS fold PAS_2 PF08446.9 001114276.1_49829001_2 - 0.077 13.5 0.4 0.27 11.8 0.0 2.1 2 0 0 2 2 2 0 PAS fold DUF2953 PF11167.6 001114276.1_49829001_2 - 0.077 12.9 0.6 0.18 11.8 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2953) ANAPC10 PF03256.14 001177927.1_49822001_2 - 3.2e-81 271.3 0.0 3.9e-81 271.0 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.23 001177927.1_49822001_2 - 9.7e-05 22.4 0.0 0.00013 21.9 0.0 1.1 1 0 0 1 1 1 1 F5/8 type C domain PITH PF06201.11 001177927.1_49822001_2 - 0.0029 17.7 0.1 0.013 15.6 0.1 1.8 1 1 1 2 2 2 1 PITH domain Lys PF00062.18 001177928.1_49821001_1 - 3e-41 140.4 1.2 3.4e-41 140.2 1.2 1.0 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family PAS PF00989.23 001177928.1_49821001_1 - 0.044 13.7 0.0 0.057 13.3 0.0 1.2 1 0 0 1 1 1 0 PAS fold GST_C_2 PF13410.4 001244428.1_49822001_3 - 5e-07 29.4 0.0 1e-06 28.4 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.4 001244428.1_49822001_3 - 3e-06 27.3 0.0 7.1e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.4 001244428.1_49822001_3 - 4.8e-06 26.7 0.0 8.9e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.22 001244428.1_49822001_3 - 0.0015 18.6 0.0 0.0027 17.8 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin GST_C PF00043.23 001244428.1_49822001_3 - 0.034 14.2 0.2 0.15 12.2 0.1 2.2 2 1 1 3 3 3 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.2 001244428.1_49822001_3 - 0.068 13.8 0.1 0.18 12.4 0.1 1.7 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain Pescadillo_N PF06732.9 001244432.1_49825001_3 - 7.2e-131 435.6 4.2 7.2e-131 435.6 4.2 2.0 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.3 001244432.1_49825001_3 - 8.8e-10 38.7 0.0 1.7e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.24 001244432.1_49825001_3 - 0.0032 17.7 0.0 0.0088 16.3 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Trm112p PF03966.14 001271968.1_49823001_1 - 1.6e-07 31.6 0.0 3.6e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Trm112p-like protein PIG-Y PF15159.4 001271968.1_49823001_3 - 5.7e-17 62.1 2.2 1.1e-16 61.2 2.2 1.5 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y Lectin_C PF00059.19 001184946.1_49829001_1 - 7.6e-136 444.7 58.7 7.3e-19 68.4 0.9 10.6 10 0 0 10 10 10 10 Lectin C-type domain fn2 PF00040.17 001184946.1_49829001_1 - 3.1e-14 52.8 4.6 1.4e-13 50.7 4.6 2.3 1 0 0 1 1 1 1 Fibronectin type II domain UL45 PF05473.10 001184946.1_49829001_1 - 2.8e-10 40.0 15.7 0.054 13.0 0.0 9.1 10 1 1 11 11 11 3 UL45 protein, carbohydrate-binding C-type lectin-like Chordopox_A33R PF05966.10 001184946.1_49829001_1 - 1.1e-07 31.2 13.9 0.073 12.2 0.1 6.9 7 0 0 7 7 7 3 Chordopoxvirus A33R protein Xlink PF00193.15 001184946.1_49829001_1 - 5.1e-05 23.4 11.8 4.7 7.5 0.0 7.9 8 1 1 9 9 9 1 Extracellular link domain Intimin_C PF07979.9 001184946.1_49829001_1 - 0.004 17.4 1.4 19 5.6 0.0 5.8 7 0 0 7 7 7 1 Intimin C-type lectin domain DBC1 PF14443.4 001206340.1_49828001_1 - 7.9e-41 138.8 0.0 1.6e-40 137.8 0.0 1.5 1 0 0 1 1 1 1 DBC1 S1-like PF14444.4 001206340.1_49828001_1 - 1.3e-26 92.2 0.2 2.5e-26 91.4 0.2 1.5 1 0 0 1 1 1 1 S1-like EKLF_TAD1 PF16832.3 001206340.1_49828001_1 - 0.0082 15.8 0.1 0.025 14.3 0.1 1.8 1 0 0 1 1 1 1 Erythroid krueppel-like transcription factor, transactivation 1 Snapin_Pallidin PF14712.4 001206340.1_49828001_1 - 0.16 12.3 7.9 0.39 11.1 7.9 1.6 1 0 0 1 1 1 0 Snapin/Pallidin ADIP PF11559.6 001206340.1_49828001_1 - 0.16 11.9 7.8 0.43 10.5 7.8 1.6 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding TBPIP PF07106.11 001206340.1_49828001_1 - 0.2 11.3 2.7 0.41 10.3 2.7 1.4 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) BLOC1_2 PF10046.7 001206340.1_49828001_1 - 0.44 10.7 4.3 0.86 9.8 4.3 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 IncA PF04156.12 001206340.1_49828001_1 - 6 6.5 11.4 0.047 13.3 3.3 1.6 2 0 0 2 2 2 0 IncA protein DUF972 PF06156.11 001206340.1_49828001_1 - 8.4 6.9 9.7 0.88 10.1 5.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF972) RRM_7 PF16367.3 001185049.1_49829001_2 - 1.9e-35 120.7 0.0 3.8e-34 116.6 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif CEBP_ZZ PF16366.3 001185049.1_49829001_2 - 4.6e-20 71.5 5.4 4.6e-20 71.5 5.4 2.7 2 0 0 2 2 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.20 001185049.1_49829001_2 - 9.4e-11 41.3 0.0 3.8e-06 26.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ribosomal_L24 PF17136.2 001244448.1_49822001_2 - 3.5e-13 49.6 0.0 6e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.27 001244448.1_49822001_2 - 1.4e-08 34.3 1.4 2.9e-08 33.2 1.4 1.6 1 0 0 1 1 1 1 KOW motif Josephin PF02099.15 001123081.1_49823001_1 - 1.1e-54 184.7 0.0 1.1e-54 184.7 0.0 1.8 2 1 0 2 2 2 1 Josephin SUIM_assoc PF16619.3 001123081.1_49823001_1 - 4.1e-33 113.2 6.5 1.1e-32 111.7 6.5 1.8 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 UIM PF02809.18 001123081.1_49823001_1 - 1e-11 43.8 28.3 6.8e-05 22.4 0.6 5.1 5 0 0 5 5 5 3 Ubiquitin interaction motif NDK PF00334.17 001244449.1_49822001_1 - 1.3e-54 183.7 0.0 1.6e-54 183.4 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase polyprenyl_synt PF00348.15 001185131.1_49823001_1 - 3.2e-96 321.2 0.0 3.9e-96 320.9 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase NDK PF00334.17 001244450.1_49822001_1 - 1.3e-54 183.7 0.0 1.6e-54 183.4 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Acyltransferase PF01553.19 001185140.1_49825001_1 - 3.9e-25 87.9 0.0 7.1e-25 87.1 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase SH3_1 PF00018.26 001123142.1_49824001_1 - 2.9e-25 87.4 0.0 2.7e-13 49.2 0.0 2.7 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.4 001123142.1_49824001_1 - 6.5e-20 70.6 0.0 2.8e-09 36.5 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain TPR_1 PF00515.26 001123142.1_49824001_1 - 5.2e-17 60.7 0.6 1.8e-06 27.4 0.2 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat SH3_2 PF07653.15 001123142.1_49824001_1 - 6.9e-17 60.8 0.0 1.9e-10 40.1 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain TPR_2 PF07719.15 001123142.1_49824001_1 - 4.8e-16 57.4 0.5 7.7e-05 22.4 0.2 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.4 001123142.1_49824001_1 - 7.7e-11 41.2 0.4 0.00079 19.3 0.3 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat PB1 PF00564.22 001123142.1_49824001_1 - 9.1e-10 38.2 0.0 2e-09 37.1 0.0 1.6 2 0 0 2 2 1 1 PB1 domain TPR_12 PF13424.4 001123142.1_49824001_1 - 1.4e-08 34.8 0.1 1.5e-05 25.1 0.0 3.0 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.4 001123142.1_49824001_1 - 0.00027 20.6 0.0 7.3 6.7 0.0 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.4 001123142.1_49824001_1 - 0.00099 18.8 0.0 1.3 8.9 0.1 3.5 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 001123142.1_49824001_1 - 0.0018 18.8 0.1 5.9 7.6 0.0 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat ANAPC5 PF12862.5 001123142.1_49824001_1 - 0.0019 18.1 0.1 0.011 15.6 0.1 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 5 TPR_9 PF13371.4 001123142.1_49824001_1 - 0.0052 16.8 0.1 0.02 14.9 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.4 001123142.1_49824001_1 - 0.01 15.4 0.1 0.67 9.6 0.1 2.8 1 1 1 2 2 2 0 TPR repeat TPR_17 PF13431.4 001123142.1_49824001_1 - 0.012 15.8 0.9 0.35 11.2 0.0 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_6 PF13174.4 001123142.1_49824001_1 - 0.04 14.4 2.1 1.5 9.5 0.3 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat SusD-like_3 PF14322.4 001123142.1_49824001_1 - 0.12 12.5 0.5 5.4 7.2 0.1 2.4 1 1 1 2 2 2 0 Starch-binding associating with outer membrane FA_desaturase PF00487.22 001206434.1_49824001_3 - 3.6e-33 115.3 25.6 3.6e-33 115.3 25.6 2.1 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.26 001206434.1_49824001_3 - 7.3e-18 64.3 0.0 1.3e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Plug_translocon PF10559.7 001206434.1_49824001_3 - 0.078 12.7 0.5 0.22 11.3 0.5 1.7 1 0 0 1 1 1 0 Plug domain of Sec61p SH3_2 PF07653.15 001244459.1_49825001_1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Variant SH3 domain Pkinase PF00069.23 001244459.1_49825001_3 - 1.5e-69 234.2 0.0 2.1e-69 233.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001244459.1_49825001_3 - 4.2e-35 121.2 0.0 5.8e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.22 001244459.1_49825001_3 - 2.9e-06 27.7 0.0 6.1e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 001244459.1_49825001_3 - 8.1e-06 25.2 0.1 2e-05 23.9 0.1 1.6 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.12 001244459.1_49825001_3 - 0.0089 15.3 0.0 0.014 14.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 001244459.1_49825001_3 - 0.012 15.1 0.1 1.6 8.1 0.1 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pacs-1 PF10254.7 001244459.1_49825001_3 - 0.14 10.9 0.1 0.23 10.2 0.1 1.2 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein Perilipin PF03036.14 001123135.1_49823001_3 - 6e-125 417.2 2.2 5.4e-124 414.1 2.2 1.9 1 1 0 1 1 1 1 Perilipin family bZIP_1 PF00170.19 001123135.1_49823001_3 - 0.03 14.3 1.5 6.3 6.8 0.1 2.8 2 0 0 2 2 2 0 bZIP transcription factor V-SNARE PF05008.13 001123135.1_49823001_3 - 0.071 13.4 0.0 6.5 7.1 0.0 2.9 3 0 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus ApoO PF09769.7 001123135.1_49823001_3 - 0.078 12.8 0.1 1.3 8.9 0.0 2.7 3 0 0 3 3 3 0 Apolipoprotein O Lipase_chap PF03280.12 001123135.1_49823001_3 - 1.6 8.6 5.8 8.3 6.2 0.1 2.7 3 0 0 3 3 3 0 Proteobacterial lipase chaperone protein EAF PF09816.7 001206456.1_49829001_1 - 8.2e-23 80.6 0.0 1.4e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor SelP_N PF04592.12 001206456.1_49829001_2 - 1 8.6 9.1 1.5 8.0 9.1 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region ART PF01129.16 001272094.1_49824001_1 - 1.3e-48 165.1 0.3 1.7e-48 164.7 0.3 1.1 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase A_deaminase PF00962.20 001123076.1_49825001_1 - 2.5e-134 447.6 0.2 3.7e-134 447.0 0.2 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase EF-hand_7 PF13499.4 001244466.1_49827001_1 - 5.3e-26 90.7 2.5 3.9e-17 62.4 0.0 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.30 001244466.1_49827001_1 - 6.5e-23 78.4 4.3 3.3e-06 26.1 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.4 001244466.1_49827001_1 - 1.2e-20 71.9 2.8 1.2e-06 27.7 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 001244466.1_49827001_1 - 1.2e-19 68.3 1.8 1.9e-05 24.1 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 001244466.1_49827001_1 - 1.6e-16 59.7 1.1 2.7e-06 26.9 0.0 3.5 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001244466.1_49827001_1 - 0.00023 21.3 0.1 0.057 13.6 0.0 3.0 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 001244466.1_49827001_1 - 0.0038 17.0 0.3 2.1 8.2 0.0 2.9 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.4 001244465.1_49828001_2 - 4.5e-26 91.0 2.2 4.1e-17 62.3 0.0 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.30 001244465.1_49828001_2 - 7.9e-23 78.1 4.3 3.5e-06 26.0 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.4 001244465.1_49828001_2 - 1.4e-20 71.7 2.8 1.2e-06 27.6 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 001244465.1_49828001_2 - 1.5e-19 68.1 1.8 2e-05 24.0 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 001244465.1_49828001_2 - 1.8e-16 59.5 1.1 2.8e-06 26.8 0.0 3.5 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001244465.1_49828001_2 - 0.00026 21.2 0.1 0.06 13.5 0.0 3.0 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 001244465.1_49828001_2 - 0.0043 16.8 0.3 2.2 8.1 0.0 2.9 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Tetraspannin PF00335.18 001123212.1_49822001_1 - 8e-29 100.8 5.9 9.9e-29 100.5 5.9 1.1 1 0 0 1 1 1 1 Tetraspanin family PepSY_TM PF03929.14 001123212.1_49822001_1 - 0.034 13.4 0.1 0.095 11.9 0.0 1.8 2 1 0 2 2 2 0 PepSY-associated TM region RasGEF_N PF00618.18 001123212.1_49822001_1 - 0.15 12.2 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 RasGEF N-terminal motif FAM70 PF14967.4 001123212.1_49822001_1 - 0.18 11.1 1.3 0.27 10.5 1.3 1.2 1 0 0 1 1 1 0 FAM70 protein MRP-S35 PF10246.7 001185168.1_49822001_3 - 3.5e-54 181.1 0.0 6e-54 180.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein MRP-S35 S1 PF00575.21 001185168.1_49822001_3 - 0.034 14.4 0.0 0.054 13.7 0.0 1.3 1 0 0 1 1 1 0 S1 RNA binding domain PHD PF00628.27 001185175.1_49827001_1 - 8.8e-07 28.6 5.4 8.8e-07 28.6 5.4 2.4 2 0 0 2 2 2 1 PHD-finger Prok-RING_1 PF14446.4 001185175.1_49827001_1 - 0.0028 17.4 0.8 0.0028 17.4 0.8 1.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-met PF12874.5 001244480.1_49825001_3 - 1.7e-24 85.3 23.9 1.5e-07 31.4 0.5 4.5 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001244480.1_49825001_3 - 2e-14 53.3 17.9 0.0011 19.0 0.9 4.4 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-U1 PF06220.10 001244480.1_49825001_3 - 0.00054 19.5 13.5 2.1 8.1 0.5 4.3 4 0 0 4 4 4 3 U1 zinc finger zf-C2H2_2 PF12756.5 001244480.1_49825001_3 - 0.0075 16.4 6.2 0.0075 16.4 6.2 4.3 2 1 3 5 5 5 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.24 001244480.1_49825001_3 - 0.094 13.1 11.8 5.1 7.6 0.7 4.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type Vps39_2 PF10367.7 001244480.1_49825001_3 - 0.13 12.5 10.6 0.51 10.6 0.1 2.8 1 1 2 3 3 3 0 Vacuolar sorting protein 39 domain 2 zf-C2H2_4 PF13894.4 001244480.1_49825001_3 - 0.51 11.2 17.1 3.7 8.5 0.5 4.8 4 0 0 4 4 4 0 C2H2-type zinc finger Peptidase_M18 PF02127.13 001185186.1_49824001_3 - 1.4e-191 636.9 0.0 1.5e-191 636.7 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.12 001185186.1_49824001_3 - 1.7e-05 23.9 0.0 0.00018 20.5 0.0 2.1 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase LIN52 PF10044.7 001185836.1_49825001_2 - 1.8e-37 127.8 0.1 2.7e-37 127.2 0.1 1.3 1 0 0 1 1 1 1 Retinal tissue protein EF-hand_7 PF13499.4 001244488.1_49825001_1 - 5.5e-09 36.2 2.4 5.5e-09 36.2 2.4 2.7 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 001244488.1_49825001_1 - 1.4e-05 24.1 0.3 0.14 11.6 0.2 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 001244488.1_49825001_1 - 0.00048 19.7 0.5 0.054 13.3 0.2 2.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.4 001244488.1_49825001_1 - 0.14 11.6 1.2 1.2 8.7 0.1 2.9 3 0 0 3 3 3 0 EF hand UPF0542 PF15086.4 001244488.1_49825001_1 - 0.33 10.8 2.1 0.42 10.5 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 tRNA_anti-codon PF01336.23 001244491.1_49824001_1 - 1.7e-05 24.6 0.2 2.9e-05 23.8 0.2 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain W2 PF02020.16 001244493.1_49824001_2 - 8.2e-23 80.2 5.3 1.8e-20 72.7 3.4 2.8 2 0 0 2 2 2 2 eIF4-gamma/eIF5/eIF2-epsilon XPG_I_2 PF12813.5 001244493.1_49824001_2 - 0.28 10.5 2.1 0.29 10.5 0.3 1.9 3 0 0 3 3 3 0 XPG domain containing Cyclin_N PF00134.21 001190160.1_49825001_1 - 3.9e-13 49.2 2.9 4.8e-12 45.7 0.6 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C_2 PF16899.3 001190160.1_49825001_1 - 1.5e-06 28.4 0.2 3.3e-06 27.3 0.2 1.6 1 1 0 1 1 1 1 Cyclin C-terminal domain TFIIB PF00382.17 001190160.1_49825001_1 - 0.038 13.9 0.1 0.41 10.6 0.0 2.1 2 0 0 2 2 2 0 Transcription factor TFIIB repeat Redoxin PF08534.8 214144.1_49822001_1 - 1.2e-30 106.0 0.0 1.7e-30 105.5 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.19 214144.1_49822001_1 - 3.4e-12 46.2 0.0 4.6e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family DUF169 PF02596.13 214144.1_49822001_1 - 0.0075 16.1 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ArCR, COG2043 DUF4772 PF15997.3 001244496.1_49825001_1 - 3.6e-28 98.4 0.0 6.5e-28 97.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4772) FOXP-CC PF16159.3 001244496.1_49825001_1 - 0.015 15.8 0.0 0.039 14.4 0.0 1.7 1 0 0 1 1 1 0 FOXP coiled-coil domain HMG14_17 PF01101.16 001244502.1_49822001_3 - 6.6e-19 68.5 22.8 9.2e-19 68.0 22.8 1.2 1 0 0 1 1 1 1 HMG14 and HMG17 Rad51 PF08423.9 001123181.1_49824001_2 - 8.7e-130 431.4 0.1 1.1e-129 431.1 0.1 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.4 001123181.1_49824001_2 - 2.4e-10 40.2 0.0 3.7e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.19 001123181.1_49824001_2 - 9.8e-09 34.9 0.1 1.5e-08 34.3 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.4 001123181.1_49824001_2 - 4e-08 33.6 0.5 1.2e-07 32.1 0.5 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.11 001123181.1_49824001_2 - 0.00016 21.0 1.3 0.00058 19.2 1.3 1.9 1 1 0 1 1 1 1 KaiC HHH PF00633.21 001123181.1_49824001_2 - 0.12 12.2 0.1 0.38 10.6 0.1 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif SPR1 PF15356.4 001123171.1_49821001_1 - 2.5e-54 182.5 51.8 2.8e-54 182.4 51.8 1.0 1 0 0 1 1 1 1 Psoriasis susceptibility locus 2 Etmic-2 PF06670.9 001244511.1_49823001_1 - 0.064 12.1 0.7 0.091 11.6 0.7 1.1 1 0 0 1 1 1 0 Microneme protein Etmic-2 PBD PF00786.26 001190193.1_49823001_1 - 0.0028 17.9 0.1 0.0058 16.9 0.1 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain ANAPC3 PF12895.5 001278771.1_49825001_3 - 1.4e-27 95.6 14.1 1.6e-21 76.1 9.1 5.5 3 1 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.15 001278771.1_49825001_3 - 4.7e-21 73.0 19.9 0.00087 19.1 0.1 10.4 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_1 PF00515.26 001278771.1_49825001_3 - 1.3e-18 65.8 21.9 4.7e-07 29.2 0.2 8.8 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_12 PF13424.4 001278771.1_49825001_3 - 1.5e-14 53.9 14.4 1.2e-08 35.0 0.3 6.3 5 2 1 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.4 001278771.1_49825001_3 - 5.4e-13 47.9 11.5 0.0024 17.8 0.0 7.3 9 0 0 9 9 6 4 Tetratricopeptide repeat TPR_7 PF13176.4 001278771.1_49825001_3 - 1.1e-12 46.8 5.1 0.00031 20.4 0.1 5.5 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.4 001278771.1_49825001_3 - 6e-12 44.9 2.0 0.0024 17.6 0.3 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.4 001278771.1_49825001_3 - 8.6e-09 35.7 5.0 0.21 12.0 1.6 4.7 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.4 001278771.1_49825001_3 - 5.6e-07 29.4 0.2 7.9 7.0 0.0 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.4 001278771.1_49825001_3 - 2e-06 27.2 4.1 0.00014 21.4 0.1 4.6 5 0 0 5 5 5 1 TPR repeat TPR_9 PF13371.4 001278771.1_49825001_3 - 4.3e-06 26.7 1.5 0.24 11.5 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.4 001278771.1_49825001_3 - 0.00017 22.1 14.7 0.87 10.2 0.0 5.5 5 1 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.4 001278771.1_49825001_3 - 0.0011 19.4 16.0 12 6.9 0.0 8.0 5 3 4 9 9 8 0 Tetratricopeptide repeat TPR_6 PF13174.4 001278771.1_49825001_3 - 0.025 15.0 9.4 1.9 9.2 0.2 5.5 6 0 0 6 6 5 0 Tetratricopeptide repeat SRP_TPR_like PF17004.3 001278771.1_49825001_3 - 0.026 14.4 8.0 0.11 12.4 2.1 3.3 3 0 0 3 3 3 0 Putative TPR-like repeat Fis1_TPR_C PF14853.4 001278771.1_49825001_3 - 1.2 9.1 5.2 6.6 6.7 0.1 4.1 3 1 1 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat INSIG PF07281.10 001244521.1_49826001_3 - 6.2e-46 156.6 7.8 1.8e-45 155.0 7.8 1.7 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) DUF202 PF02656.13 001244521.1_49826001_3 - 3.1 8.2 6.6 1.8 8.9 1.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF202) 4F5 PF04419.12 001190206.1_49822001_3 - 7.3e-11 42.6 10.8 7.3e-11 42.6 10.8 2.5 2 0 0 2 2 2 1 4F5 protein family DDRGK PF09756.7 001190212.1_49823001_3 - 4.9e-71 238.1 23.4 8.5e-71 237.3 23.4 1.4 1 0 0 1 1 1 1 DDRGK domain PCI PF01399.25 001190212.1_49823001_3 - 0.051 14.0 0.1 0.097 13.1 0.1 1.5 1 0 0 1 1 1 0 PCI domain DUF3347 PF11827.6 001190212.1_49823001_3 - 0.37 10.8 6.7 0.58 10.2 6.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) V_ATPase_I PF01496.17 001190212.1_49823001_3 - 0.64 7.7 2.9 0.68 7.6 2.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SKG6 PF08693.8 001190212.1_49823001_3 - 0.95 8.8 3.9 1.7 8.0 3.9 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain RR_TM4-6 PF06459.10 001190212.1_49823001_3 - 1.2 8.7 15.3 1.7 8.3 15.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FancD2 PF14631.4 001190212.1_49823001_3 - 1.9 5.7 10.0 2.4 5.3 10.0 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease DDHD PF02862.15 001190212.1_49823001_3 - 2.1 8.3 4.3 2.8 7.9 4.3 1.2 1 0 0 1 1 1 0 DDHD domain ALMT PF11744.6 001190212.1_49823001_3 - 2.3 6.8 8.9 3 6.4 8.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter NPR3 PF03666.11 001190212.1_49823001_3 - 3.2 6.3 8.8 4.5 5.8 8.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.15 001190212.1_49823001_3 - 5 5.6 9.7 7.1 5.1 9.7 1.2 1 0 0 1 1 1 0 Presenilin Nucleo_P87 PF07267.9 001190212.1_49823001_3 - 7.9 5.1 14.9 11 4.6 14.9 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Pkinase_Tyr PF07714.15 001123105.1_49826001_1 - 2.2e-84 282.7 0.0 2.8e-84 282.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001123105.1_49826001_1 - 2.4e-38 131.9 0.0 4.1e-37 127.9 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.23 001123105.1_49826001_1 - 8e-19 67.9 0.0 1.3e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Kinase-like PF14531.4 001123105.1_49826001_1 - 0.06 12.5 0.0 0.099 11.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Lamprin PF06403.9 001123105.1_49826001_1 - 0.096 12.5 0.6 0.29 11.0 0.6 1.8 1 0 0 1 1 1 0 Lamprin DUF4713 PF15831.3 001244526.1_49825001_3 - 0.61 10.4 3.5 1.1 9.6 3.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) zf-H2C2_2 PF13465.4 001285968.1_49825001_2 - 1.1e-12 47.6 20.0 3.6e-07 30.2 0.8 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.24 001285968.1_49825001_2 - 7.1e-12 45.0 15.3 0.0011 19.2 3.8 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001285968.1_49825001_2 - 1.5e-10 40.8 13.9 0.0049 17.4 2.4 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001285968.1_49825001_2 - 0.00025 20.8 5.1 0.44 10.4 0.4 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_8 PF15909.3 001285968.1_49825001_2 - 0.013 15.6 5.8 0.023 14.8 2.9 2.3 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-met PF12874.5 001285968.1_49825001_2 - 0.062 13.6 11.1 0.29 11.4 1.4 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.4 001285968.1_49825001_2 - 0.12 12.2 8.7 4.6 7.1 0.5 3.6 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Zf_RING PF16744.3 001285968.1_49825001_2 - 0.15 12.0 1.5 2.7 8.0 0.1 2.2 1 1 1 2 2 2 0 KIAA1045 RING finger zf-C2H2_11 PF16622.3 001285968.1_49825001_2 - 7.3 6.3 7.7 23 4.7 0.2 3.5 3 0 0 3 3 3 0 zinc-finger C2H2-type PMP22_Claudin PF00822.18 001244529.1_49823001_3 - 6e-10 39.1 5.4 7.3e-09 35.6 5.4 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001244529.1_49823001_3 - 0.0067 16.1 5.7 0.0067 16.1 5.7 2.6 2 1 0 3 3 3 2 PMP-22/EMP/MP20/Claudin tight junction AhpC-TSA PF00578.19 001244531.1_49824001_2 - 6.7e-37 126.0 0.0 9.4e-37 125.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.8 001244531.1_49824001_2 - 5.5e-15 55.2 0.0 8.5e-15 54.6 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.7 001244531.1_49824001_2 - 6.3e-11 41.8 0.1 1e-10 41.1 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Lectin_C PF00059.19 001285972.1_49822001_2 - 5.1e-19 68.9 0.1 6.7e-19 68.5 0.1 1.2 1 0 0 1 1 1 1 Lectin C-type domain Chordopox_A33R PF05966.10 001285972.1_49822001_2 - 0.038 13.1 0.0 0.057 12.6 0.0 1.2 1 0 0 1 1 1 0 Chordopoxvirus A33R protein ECH_1 PF00378.18 001285973.1_49823001_1 - 4.5e-82 275.0 0.0 5.8e-82 274.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 001285973.1_49823001_1 - 1.9e-12 47.2 0.0 2.5e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF1874 PF08960.8 001285973.1_49823001_1 - 0.11 12.5 0.0 21 5.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1874) TSP_C PF05735.10 001244536.1_49829001_1 - 9.8e-97 322.5 0.7 1.4e-96 322.0 0.7 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.16 001244536.1_49829001_1 - 1.4e-55 184.5 147.2 2.5e-12 46.1 12.3 9.7 7 2 2 9 9 9 8 Thrombospondin type 3 repeat TSP_1 PF00090.17 001244536.1_49829001_1 - 6.1e-45 151.1 56.2 1.6e-16 60.1 9.9 4.5 4 0 0 4 4 3 3 Thrombospondin type 1 domain VWC PF00093.16 001244536.1_49829001_1 - 2.8e-12 46.6 19.4 2.8e-12 46.6 19.4 6.0 4 3 2 6 6 1 1 von Willebrand factor type C domain EGF_3 PF12947.5 001244536.1_49829001_1 - 3.7e-06 26.9 11.2 3.7e-06 26.9 11.2 4.7 4 0 0 4 4 3 2 EGF domain cEGF PF12662.5 001244536.1_49829001_1 - 1.1e-05 25.2 16.9 0.00034 20.3 1.5 4.1 3 0 0 3 3 3 2 Complement Clr-like EGF-like EGF_CA PF07645.13 001244536.1_49829001_1 - 1.9e-05 24.7 3.3 1.9e-05 24.7 3.3 5.1 4 0 0 4 4 3 3 Calcium-binding EGF domain Laminin_G_3 PF13385.4 001244536.1_49829001_1 - 9.3e-05 22.5 1.1 0.00069 19.7 0.0 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.22 001244536.1_49829001_1 - 0.0002 21.8 0.2 0.00039 20.9 0.2 1.4 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.25 001244536.1_49829001_1 - 0.0028 17.8 12.2 0.0028 17.8 12.2 6.2 5 0 0 5 5 4 2 EGF-like domain Laminin_G_1 PF00054.21 001244536.1_49829001_1 - 0.06 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain 7tm_1 PF00001.19 001190244.1_49825001_1 - 1.3e-40 139.2 26.6 3.1e-40 138.0 26.6 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) HLH PF00010.24 001190245.1_49824001_3 - 8.1e-18 64.0 0.2 1.4e-17 63.3 0.2 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Rootletin PF15035.4 001190245.1_49824001_3 - 0.0097 15.9 4.0 0.016 15.2 4.0 1.3 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion HALZ PF02183.16 001190245.1_49824001_3 - 4.4 7.4 8.4 1.7 8.8 2.1 2.2 1 1 1 2 2 2 0 Homeobox associated leucine zipper PRY PF13765.4 001128446.1_49823001_1 - 7e-18 63.9 0.1 1.4e-17 62.9 0.1 1.5 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4 PF00097.23 001128446.1_49823001_1 - 2.8e-06 27.0 9.7 5.5e-06 26.0 9.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001128446.1_49823001_1 - 4.3e-06 26.6 13.3 8e-06 25.8 13.3 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 001128446.1_49823001_1 - 0.00017 21.3 8.6 0.00039 20.2 8.6 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 001128446.1_49823001_1 - 0.00026 20.8 13.7 0.00075 19.3 13.7 1.9 1 0 0 1 1 1 1 RING-type zinc-finger SPRY PF00622.26 001128446.1_49823001_1 - 0.00041 20.3 0.0 0.00061 19.8 0.0 1.2 1 0 0 1 1 1 1 SPRY domain zf-RING_6 PF14835.4 001128446.1_49823001_1 - 0.00098 18.8 7.1 0.0022 17.7 7.1 1.7 1 1 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.4 001128446.1_49823001_1 - 0.0015 18.6 11.5 0.0035 17.4 11.5 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001128446.1_49823001_1 - 0.0015 18.2 13.2 0.0053 16.4 13.2 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001128446.1_49823001_1 - 0.018 14.7 11.0 0.037 13.8 11.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.6 001128446.1_49823001_1 - 0.14 11.9 4.1 0.27 11.0 4.1 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Rad50_zn_hook PF04423.12 001128446.1_49823001_1 - 0.23 11.2 0.2 0.23 11.2 0.2 2.2 2 0 0 2 2 1 0 Rad50 zinc hook motif Ribosomal_S9 PF00380.17 001244553.1_49823001_3 - 9.4e-37 126.1 0.0 2.1e-36 125.0 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S9/S16 CK_II_beta PF01214.16 001244553.1_49823001_3 - 0.074 12.8 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Casein kinase II regulatory subunit DUF1356 PF07092.10 001244554.1_49825001_2 - 9.2e-111 368.5 4.7 1.1e-110 368.2 4.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) Ank_4 PF13637.4 001128449.1_49822001_3 - 4e-17 62.2 0.5 7e-10 39.1 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 001128449.1_49822001_3 - 9.5e-16 57.5 2.8 1.3e-08 34.8 0.1 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 001128449.1_49822001_3 - 6.1e-15 55.4 0.0 1.5e-13 50.9 0.1 2.9 4 0 0 4 4 4 1 Ankyrin repeats (3 copies) Ank PF00023.28 001128449.1_49822001_3 - 4.6e-12 45.7 2.0 2.2e-06 27.7 0.3 3.7 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.4 001128449.1_49822001_3 - 1e-10 40.8 2.1 2.6e-05 24.1 0.1 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ubiquitin_2 PF14560.4 001128449.1_49822001_3 - 7.4e-05 23.0 0.0 0.001 19.4 0.0 2.4 1 1 1 2 2 2 1 Ubiquitin-like domain ubiquitin PF00240.21 001128449.1_49822001_3 - 8.1e-05 22.1 0.0 0.00014 21.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family APG12 PF04110.11 001190282.1_49822001_2 - 1.2e-40 137.6 0.0 1.7e-40 137.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.14 001190282.1_49822001_2 - 6.9e-06 26.1 0.0 9.8e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Methyltransf_23 PF13489.4 001244561.1_49824001_1 - 6.1e-16 58.6 0.0 8.8e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001244561.1_49824001_1 - 9.1e-07 29.4 0.0 1.7e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001244561.1_49824001_1 - 8.9e-05 22.2 0.0 0.00014 21.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain z-alpha PF02295.15 001123216.1_49823001_2 - 8.9e-09 35.1 1.1 0.0025 17.7 0.1 2.3 2 0 0 2 2 2 2 Adenosine deaminase z-alpha domain RHIM PF12721.5 001123216.1_49823001_2 - 0.00013 22.2 9.5 0.02 15.2 4.7 3.7 3 0 0 3 3 3 2 RIP homotypic interaction motif Dimerisation2 PF16864.3 001123216.1_49823001_2 - 0.083 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Dimerisation domain Macro PF01661.19 001244562.1_49824001_3 - 2.7e-28 98.2 0.0 4.5e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 Macro domain Histone_H2A_C PF16211.3 001244562.1_49824001_3 - 1e-17 63.4 1.4 1e-17 63.4 1.4 2.2 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.22 001244562.1_49824001_3 - 3.5e-14 53.2 2.3 8e-14 52.0 0.0 2.1 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 001244562.1_49824001_3 - 0.016 15.4 0.0 0.032 14.4 0.0 1.6 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF1764 PF08576.8 001244562.1_49824001_3 - 0.13 13.0 0.5 0.3 11.8 0.5 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) YihI PF04220.10 001244562.1_49824001_3 - 0.39 10.3 3.7 4.9 6.7 0.0 2.3 2 0 0 2 2 2 0 Der GTPase activator (YihI) Tmem26 PF09772.7 001244582.1_49824001_3 - 5.8e-116 386.7 11.2 6.9e-116 386.5 11.2 1.1 1 0 0 1 1 1 1 Transmembrane protein 26 Lamp PF01299.15 001291776.1_49823001_1 - 9.4e-81 271.6 1.1 1.4e-80 271.1 1.1 1.2 1 0 0 1 1 1 1 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.10 001291776.1_49823001_1 - 0.00054 19.7 0.1 0.00086 19.0 0.1 1.3 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Endomucin PF07010.10 001291776.1_49823001_1 - 0.00096 19.1 14.9 0.25 11.2 10.5 2.2 2 0 0 2 2 2 2 Endomucin Mucin PF01456.15 001291776.1_49823001_1 - 2.4 8.0 24.2 4.2 7.2 24.2 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein EF-hand_7 PF13499.4 001244619.1_49822001_3 - 4.4e-18 65.4 0.2 1.3e-07 31.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 001244619.1_49822001_3 - 8.4e-11 40.5 1.7 0.092 12.2 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.4 001244619.1_49822001_3 - 4.8e-10 38.4 0.9 0.027 14.3 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 001244619.1_49822001_3 - 1.4e-09 37.5 1.7 2.1e-07 30.5 0.1 3.0 1 1 2 3 3 3 1 EF-hand domain pair EF-hand_9 PF14658.4 001244619.1_49822001_3 - 6.3e-09 35.9 0.2 4.8e-06 26.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 001244619.1_49822001_3 - 0.00018 21.2 0.1 0.17 11.7 0.0 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand GPHH PF16905.3 001244619.1_49822001_3 - 0.0018 17.9 0.0 0.034 13.8 0.0 2.5 2 0 0 2 2 2 1 Voltage-dependent L-type calcium channel, IQ-associated FlgD PF03963.12 001244619.1_49822001_3 - 0.0039 17.3 0.1 0.0093 16.1 0.1 1.6 1 0 0 1 1 1 1 Flagellar hook capping protein - N-terminal region EF-hand_11 PF08976.9 001244619.1_49822001_3 - 0.035 14.9 0.0 0.1 13.3 0.0 1.7 2 0 0 2 2 2 0 EF-hand domain zf-C2H2 PF00096.24 001128439.1_49822001_2 - 1.8e-26 90.9 32.4 4.9e-06 26.6 0.4 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001128439.1_49822001_2 - 8.5e-21 72.7 32.4 6.6e-05 23.3 1.3 5.6 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001128439.1_49822001_2 - 2.2e-18 65.7 32.9 9.3e-08 32.1 0.5 5.8 5 1 0 5 5 5 4 Zinc-finger double domain zf-C2H2_6 PF13912.4 001128439.1_49822001_2 - 2.1e-14 52.9 26.2 0.00031 20.5 4.0 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001128439.1_49822001_2 - 1.7e-13 50.3 20.9 0.0018 18.4 0.1 5.7 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 001128439.1_49822001_2 - 7.9e-08 32.3 17.0 0.0074 16.4 3.4 3.6 3 1 0 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 001128439.1_49822001_2 - 1.1e-06 28.6 25.4 0.073 13.3 0.7 5.6 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-BED PF02892.13 001128439.1_49822001_2 - 2.4e-05 24.2 25.7 0.5 10.3 0.4 5.5 2 1 3 5 5 5 4 BED zinc finger zf-C2HE PF16278.3 001128439.1_49822001_2 - 0.00012 22.3 27.8 0.11 12.9 1.2 4.8 1 1 4 5 5 5 3 C2HE / C2H2 / C2HC zinc-binding finger zf-C2HC_2 PF13913.4 001128439.1_49822001_2 - 0.0021 17.8 19.0 1.2 9.0 0.8 5.3 5 0 0 5 5 5 3 zinc-finger of a C2HC-type zinc_ribbon_15 PF17032.3 001128439.1_49822001_2 - 0.011 16.3 0.9 0.011 16.3 0.9 2.9 2 1 0 2 2 1 0 zinc-ribbon family zf-H2C2_5 PF13909.4 001128439.1_49822001_2 - 0.013 15.1 0.7 0.013 15.1 0.7 5.5 5 1 0 5 5 4 0 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.5 001128439.1_49822001_2 - 0.032 14.4 21.7 3.1 8.1 0.3 5.0 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.8 001128439.1_49822001_2 - 0.29 11.1 22.2 0.54 10.3 2.1 4.3 3 1 1 4 4 4 0 Zinc ribbon domain zf-CHY PF05495.10 001128439.1_49822001_2 - 0.39 11.2 21.6 0.73 10.3 5.4 2.5 2 0 0 2 2 2 0 CHY zinc finger PyrI_C PF02748.13 001128439.1_49822001_2 - 0.48 10.2 16.3 2.5 7.9 1.7 4.8 5 0 0 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-LYAR PF08790.9 001128439.1_49822001_2 - 2.1 8.2 12.7 6.3 6.7 0.2 4.7 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger Zn_Tnp_IS1595 PF12760.5 001128439.1_49822001_2 - 2.4 8.1 25.3 0.13 12.1 5.9 4.1 3 1 1 4 4 4 0 Transposase zinc-ribbon domain zf-AN1 PF01428.14 001128439.1_49822001_2 - 4.1 7.5 26.4 8.6 6.5 1.9 5.2 5 0 0 5 5 5 0 AN1-like Zinc finger Ogr_Delta PF04606.10 001128439.1_49822001_2 - 4.6 7.2 12.2 0.058 13.2 3.7 2.3 3 0 0 3 3 2 0 Ogr/Delta-like zinc finger zf-HYPF PF07503.10 001128439.1_49822001_2 - 8.7 6.1 12.1 21 4.8 3.0 3.4 2 2 0 2 2 2 0 HypF finger Pkinase PF00069.23 001128443.1_49823001_1 - 1.7e-68 230.7 0.0 2.1e-68 230.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001128443.1_49823001_1 - 5e-24 84.8 0.0 6.8e-24 84.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001128443.1_49823001_1 - 5.7e-05 22.4 0.0 0.00037 19.8 0.0 1.9 1 1 1 2 2 2 1 Kinase-like APH PF01636.21 001128443.1_49823001_1 - 0.006 16.4 0.1 0.013 15.3 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.12 001128443.1_49823001_1 - 0.018 14.2 0.0 0.028 13.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.14 001128443.1_49823001_1 - 0.085 12.9 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 ABC1 family Cytochrom_B561 PF03188.14 001128452.1_49822001_2 - 4e-46 156.4 12.3 4e-46 156.4 12.3 1.9 3 0 0 3 3 3 1 Eukaryotic cytochrome b561 DUF2374 PF09574.8 001128452.1_49822001_2 - 0.36 10.5 6.9 6 6.6 0.7 2.9 2 0 0 2 2 2 0 Protein of unknown function (Duf2374) JTB PF05439.10 001128468.1_49822001_3 - 1.9e-36 124.3 6.4 2.5e-36 123.9 6.4 1.2 1 0 0 1 1 1 1 Jumping translocation breakpoint protein (JTB) HPD PF05044.10 001128490.1_49825001_1 - 1.6e-83 278.1 2.2 3e-83 277.3 2.2 1.5 1 0 0 1 1 1 1 Homeo-prospero domain NifQ PF04891.10 001128490.1_49825001_1 - 0.016 15.4 4.1 0.43 10.8 0.0 3.4 3 0 0 3 3 3 0 NifQ Metal_resist PF13801.4 001128490.1_49825001_1 - 0.031 14.3 9.9 0.084 12.9 8.6 2.3 2 0 0 2 2 2 0 Heavy-metal resistance DUF2968 PF11180.6 001128490.1_49825001_1 - 0.36 10.4 16.0 0.79 9.3 16.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) PP_kinase_N PF13089.4 001128490.1_49825001_1 - 0.56 10.4 9.1 2.1 8.6 4.4 3.6 3 1 1 4 4 4 0 Polyphosphate kinase N-terminal domain DUF4613 PF15390.4 001128490.1_49825001_1 - 0.74 8.0 7.5 1.1 7.4 7.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) FliD_N PF02465.16 001128490.1_49825001_1 - 0.81 10.3 4.2 12 6.6 4.8 2.7 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus zf-CpG_bind_C PF12269.6 001128490.1_49825001_1 - 1.1 8.9 7.0 2.5 7.7 7.0 1.6 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain DUF342 PF03961.11 001128490.1_49825001_1 - 2.4 6.6 4.8 3.8 5.9 4.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Fibrinogen_C PF00147.16 001128453.1_49823001_3 - 0.00026 20.7 0.2 0.00041 20.1 0.2 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain 7tm_2 PF00002.22 001195117.1_49823001_3 - 8.2e-85 283.9 14.5 1e-84 283.5 14.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001195117.1_49823001_3 - 2e-22 79.1 3.7 2e-22 79.1 3.7 2.0 2 0 0 2 2 2 1 Hormone receptor domain MIP PF00230.18 001128454.1_49822001_1 - 1.5e-44 152.3 8.3 1.9e-44 151.9 8.3 1.1 1 0 0 1 1 1 1 Major intrinsic protein zf-C2H2 PF00096.24 001244656.1_49824001_1 - 4.4e-14 51.9 55.4 0.039 14.3 2.9 9.8 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-H2C2_5 PF13909.4 001244656.1_49824001_1 - 8.3e-12 44.5 32.8 0.00047 19.7 0.3 6.8 6 0 0 6 6 6 3 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.4 001244656.1_49824001_1 - 3.5e-11 42.8 56.7 0.069 13.9 0.9 9.9 9 0 0 9 9 9 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001244656.1_49824001_1 - 4.6e-10 39.3 48.5 7.6e-05 22.8 0.1 9.7 10 0 0 10 10 10 6 Zinc-finger double domain zinc_ribbon_15 PF17032.3 001244656.1_49824001_1 - 0.15 12.7 30.5 0.28 11.8 2.9 5.2 3 1 1 4 4 4 0 zinc-ribbon family zf-C2H2_8 PF15909.3 001244656.1_49824001_1 - 0.23 11.6 29.4 0.088 13.0 0.6 5.3 2 2 3 5 5 5 0 C2H2-type zinc ribbon CarbpepA_inh PF02977.13 001244656.1_49824001_1 - 0.24 11.1 8.8 2.4 7.9 0.0 4.4 4 0 0 4 4 4 0 Carboxypeptidase A inhibitor DZR PF12773.5 001244656.1_49824001_1 - 1.1 9.2 20.9 2 8.4 0.6 4.9 3 1 1 4 4 4 0 Double zinc ribbon Homeobox PF00046.27 001195232.1_49825001_2 - 2.1e-21 75.3 8.0 3.6e-21 74.6 8.0 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001195232.1_49825001_2 - 0.12 12.2 0.6 0.82 9.5 0.8 2.1 2 0 0 2 2 2 0 Homeobox KN domain RNase_PH PF01138.19 001244661.1_49823001_2 - 3.6e-23 82.4 0.1 6.4e-23 81.6 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.13 001244661.1_49823001_2 - 9e-09 35.1 0.0 1.4e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Toxin_30 PF08117.9 001244661.1_49823001_3 - 0.046 13.8 3.6 0.8 9.9 0.0 3.8 4 0 0 4 4 4 0 Ptu family Orn_Arg_deC_N PF02784.14 001128488.2_49828001_1 - 9.5e-64 215.0 0.1 1.2e-63 214.7 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001128488.2_49828001_1 - 8.8e-24 83.6 0.0 1.4e-23 82.9 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain DUF4061 PF13270.4 001244669.1_49823001_3 - 6.4e-30 103.2 2.9 1e-29 102.6 2.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4061) TMEM101 PF15111.4 001244685.1_49824001_1 - 3.4e-116 387.0 4.9 4.4e-116 386.6 4.9 1.1 1 0 0 1 1 1 1 TMEM101 protein family DUF4529 PF15032.4 001244685.1_49824001_1 - 0.0033 16.5 0.6 0.0033 16.5 0.6 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF4529) SR-25 PF10500.7 001244685.1_49824001_1 - 0.2 11.1 16.1 0.26 10.7 16.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ETRAMP PF09716.8 001244685.1_49824001_2 - 3.8 7.5 10.8 15 5.6 10.8 1.9 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) V-set PF07686.15 001243436.2_49822001_2 - 0.0062 16.5 0.5 0.01 15.9 0.5 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain 7tm_1 PF00001.19 001302771.1_49823001_1 - 7.6e-22 77.7 9.7 1.2e-21 77.1 9.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ATG27 PF09451.8 001302771.1_49823001_1 - 0.18 11.5 1.0 0.35 10.5 1.0 1.4 1 0 0 1 1 1 0 Autophagy-related protein 27 Ribosomal_L36e PF01158.16 001244687.1_49821001_1 - 2.6e-51 171.7 8.4 3.5e-51 171.3 8.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L36e 7tm_1 PF00001.19 001243435.2_49824001_3 - 2.6e-46 157.9 24.6 3.5e-46 157.5 24.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001243435.2_49824001_3 - 1.6e-11 44.4 22.6 2.4e-11 43.7 22.6 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001243435.2_49824001_3 - 8.3e-11 41.6 25.8 1.3e-10 41.0 25.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx ATG27 PF09451.8 001243435.2_49824001_3 - 0.28 10.8 1.2 0.59 9.8 1.2 1.4 1 0 0 1 1 1 0 Autophagy-related protein 27 PLAC8 PF04749.15 001244689.1_49822001_1 - 1.3e-15 58.0 10.2 2.3e-15 57.2 10.2 1.4 1 0 0 1 1 1 1 PLAC8 family Lectin_C PF00059.19 001129972.1_49822001_1 - 9.3e-23 80.9 8.4 1.5e-22 80.2 8.4 1.3 1 0 0 1 1 1 1 Lectin C-type domain STAT_bind PF02864.13 001197305.1_49826001_3 - 2.1e-73 247.2 0.8 2.1e-73 247.2 0.8 2.0 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 001197305.1_49826001_3 - 1.1e-53 181.6 13.1 1.1e-53 181.6 13.1 1.7 2 0 0 2 2 2 1 STAT protein, all-alpha domain STAT_int PF02865.15 001197305.1_49826001_3 - 4.5e-38 130.3 4.7 4.5e-38 130.3 4.7 3.4 3 1 0 4 4 4 1 STAT protein, protein interaction domain SH2 PF00017.22 001197305.1_49826001_3 - 8.8e-12 44.8 0.0 5.5e-11 42.2 0.0 2.4 2 0 0 2 2 2 1 SH2 domain STAT1_TAZ2bind PF12162.6 001197305.1_49826001_3 - 0.13 11.8 0.5 0.28 10.6 0.5 1.6 1 0 0 1 1 1 0 STAT1 TAZ2 binding domain NPV_P10 PF05531.10 001197305.1_49826001_3 - 0.22 11.9 4.8 0.36 11.2 2.1 2.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Tetraspannin PF00335.18 001145218.2_49825001_3 - 6.1e-52 176.3 10.7 8e-52 176.0 10.7 1.1 1 0 0 1 1 1 1 Tetraspanin family CD20 PF04103.13 001145218.2_49825001_3 - 0.0067 16.4 5.3 0.0067 16.4 5.3 2.4 3 0 0 3 3 3 1 CD20-like family MOEP19 PF16005.3 001198917.1_49821001_1 - 1e-38 131.1 0.3 1.5e-38 130.6 0.3 1.2 1 0 0 1 1 1 1 KH-like RNA-binding domain SLT_2 PF13406.4 001198917.1_49821001_1 - 0.089 11.9 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Transglycosylase SLT domain MIIP PF15734.3 001244704.1_49824001_1 - 2.1e-152 507.5 12.9 2.5e-152 507.3 12.9 1.1 1 0 0 1 1 1 1 Migration and invasion-inhibitory GATA-N PF05349.10 214293.1_49823001_1 - 4.3e-51 173.6 22.3 4.3e-51 173.6 22.3 2.0 2 0 0 2 2 2 1 GATA-type transcription activator, N-terminal GATA PF00320.25 214293.1_49823001_1 - 9.4e-29 98.6 14.8 7.1e-15 54.2 4.3 2.4 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.10 214293.1_49823001_1 - 1.7e-06 27.3 4.1 0.018 14.4 0.6 2.3 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.8 214293.1_49823001_1 - 0.081 12.9 4.6 1 9.4 0.3 2.8 2 1 1 3 3 3 0 Zinc ribbon domain OrfB_Zn_ribbon PF07282.9 214293.1_49823001_1 - 0.29 11.0 5.1 3.1 7.7 0.3 2.4 2 0 0 2 2 2 0 Putative transposase DNA-binding domain DUF2387 PF09526.8 214293.1_49823001_1 - 0.29 11.2 3.9 19 5.4 0.3 3.0 1 1 2 3 3 3 0 Probable metal-binding protein (DUF2387) Prim_Zn_Ribbon PF08273.10 214293.1_49823001_1 - 0.3 11.4 8.2 0.15 12.3 1.6 2.6 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DZR PF12773.5 214293.1_49823001_1 - 0.35 10.8 6.9 5.4 7.0 0.6 2.6 1 1 2 3 3 3 0 Double zinc ribbon Auto_anti-p27 PF06677.10 214293.1_49823001_1 - 0.42 10.7 5.5 1.2 9.2 0.5 2.3 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) eIF-5_eIF-2B PF01873.15 214293.1_49823001_1 - 0.44 10.3 4.8 8.6 6.2 1.0 2.2 2 0 0 2 2 2 0 Domain found in IF2B/IF5 zf-RRN7 PF11781.6 214293.1_49823001_1 - 1.3 8.6 9.0 5.1 6.7 2.1 2.3 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 ThiS PF02597.18 001244725.1_49824001_2 - 5.7e-13 49.2 0.0 7.9e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 ThiS family MoaE PF02391.15 001244725.1_49824001_3 - 4.4e-39 133.1 0.0 5.8e-39 132.7 0.0 1.2 1 0 0 1 1 1 1 MoaE protein DUF974 PF06159.11 001244746.1_49824001_1 - 5.2e-85 285.0 0.3 7.1e-85 284.6 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF974) Trs65 PF12735.5 001244746.1_49824001_1 - 0.0037 16.6 0.0 9.5 5.4 0.0 3.1 3 0 0 3 3 3 2 TRAPP trafficking subunit Trs65 Transglut_C PF00927.20 001244746.1_49824001_1 - 0.04 13.9 0.2 0.37 10.8 0.0 2.5 3 0 0 3 3 3 0 Transglutaminase family, C-terminal ig like domain AICARFT_IMPCHas PF01808.16 001130736.1_49824001_3 - 3.1e-95 318.9 0.0 4e-95 318.5 0.0 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.20 001130736.1_49824001_3 - 2e-25 88.6 0.0 3.6e-25 87.8 0.0 1.4 1 0 0 1 1 1 1 MGS-like domain Ribosomal_L12_N PF16320.3 001130736.1_49824001_3 - 0.0095 15.5 1.2 0.035 13.7 1.2 1.9 1 0 0 1 1 1 1 Ribosomal protein L7/L12 dimerisation domain SOAR PF16533.3 001130974.1_49825001_1 - 3e-43 145.7 1.6 3e-43 145.7 1.6 3.6 3 1 0 3 3 3 1 STIM1 Orai1-activating region SAM_2 PF07647.15 001130974.1_49825001_1 - 3e-07 30.3 0.3 1.1e-06 28.5 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001130974.1_49825001_1 - 8e-05 22.9 0.1 0.00028 21.1 0.1 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ste50p-SAM PF09235.8 001130974.1_49825001_1 - 0.076 13.1 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Ste50p, sterile alpha motif Prominin PF05478.9 001130974.1_49825001_1 - 0.25 9.1 7.9 0.37 8.5 7.9 1.1 1 0 0 1 1 1 0 Prominin APG6 PF04111.10 001130974.1_49825001_1 - 0.43 9.8 20.2 0.7 9.1 20.2 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 AAA_23 PF13476.4 001130974.1_49825001_1 - 0.52 10.7 16.6 0.8 10.0 10.3 3.2 2 1 0 2 2 2 0 AAA domain DUF4446 PF14584.4 001130974.1_49825001_1 - 1.3 8.8 7.2 0.17 11.8 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) TMPIT PF07851.11 001130974.1_49825001_1 - 1.5 7.8 10.7 2.8 6.9 10.7 1.5 1 0 0 1 1 1 0 TMPIT-like protein FUSC PF04632.10 001130974.1_49825001_1 - 4.1 5.7 4.7 8.8 4.6 4.7 1.5 1 0 0 1 1 1 0 Fusaric acid resistance protein family ARL2_Bind_BART PF11527.6 001244775.1_49823001_1 - 5.5e-41 139.2 1.1 1.3e-40 137.9 1.1 1.7 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART SUIM_assoc PF16619.3 001244775.1_49823001_1 - 1.4 9.0 11.5 0.56 10.2 0.7 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TPR_2 PF07719.15 001244787.1_49825001_3 - 1.4e-37 124.6 22.0 0.00014 21.6 0.0 10.0 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_1 PF00515.26 001244787.1_49825001_3 - 1.5e-33 113.1 24.5 5.1e-05 22.8 0.0 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.4 001244787.1_49825001_3 - 7.2e-30 100.6 17.4 5.5e-06 26.1 0.0 9.1 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_11 PF13414.4 001244787.1_49825001_3 - 2.5e-21 74.9 13.0 1e-07 31.4 0.0 7.4 3 2 5 8 8 7 5 TPR repeat TPR_19 PF14559.4 001244787.1_49825001_3 - 6.6e-19 68.1 17.1 9.7e-07 29.1 0.1 6.1 4 2 4 8 8 7 6 Tetratricopeptide repeat TPR_17 PF13431.4 001244787.1_49825001_3 - 2.1e-15 55.8 14.1 0.0037 17.4 0.0 8.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.4 001244787.1_49825001_3 - 2.4e-15 56.5 21.3 3.8e-06 27.0 0.2 7.1 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.4 001244787.1_49825001_3 - 5.4e-15 55.7 0.3 0.015 15.8 0.0 6.1 4 1 3 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.4 001244787.1_49825001_3 - 6.1e-15 54.5 5.0 0.0015 19.0 0.0 7.6 2 2 6 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.4 001244787.1_49825001_3 - 3.1e-14 52.8 0.4 7.1e-05 22.8 0.0 5.2 2 2 4 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.5 001244787.1_49825001_3 - 1.5e-10 41.0 27.4 8.7e-05 22.5 0.1 5.8 3 2 3 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.4 001244787.1_49825001_3 - 1.6e-08 33.8 15.0 0.0023 17.7 0.0 7.7 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_6 PF13174.4 001244787.1_49825001_3 - 5.5e-08 32.8 15.2 1.2 9.8 0.0 9.1 10 0 0 10 10 9 1 Tetratricopeptide repeat PknG_TPR PF16918.3 001244787.1_49825001_3 - 6.3e-07 28.3 0.5 0.01 14.5 0.1 2.6 3 0 0 3 3 3 2 Protein kinase G tetratricopeptide repeat Wzy_C_2 PF11846.6 001244787.1_49825001_3 - 2.3e-06 27.5 1.4 0.21 11.3 0.0 4.0 3 1 1 4 4 4 2 Virulence factor membrane-bound polymerase, C-terminal NARP1 PF12569.6 001244787.1_49825001_3 - 2.7e-05 23.2 4.9 0.035 12.8 0.1 3.8 2 1 3 5 5 5 1 NMDA receptor-regulated protein 1 TPR_15 PF13429.4 001244787.1_49825001_3 - 7.2e-05 22.0 5.9 0.0052 15.9 0.4 3.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.4 001244787.1_49825001_3 - 0.0011 18.6 21.7 2.5 8.0 0.1 7.3 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_20 PF14561.4 001244787.1_49825001_3 - 0.0026 17.9 2.3 0.91 9.8 0.0 4.1 4 1 0 4 4 4 1 Tetratricopeptide repeat Mu-like_Pro PF10123.7 001244787.1_49825001_3 - 0.022 14.1 0.7 0.32 10.3 0.0 2.5 2 1 1 3 3 3 0 Mu-like prophage I protein ChAPs PF09295.8 001244787.1_49825001_3 - 0.029 13.3 1.1 1.6 7.5 0.0 2.8 2 1 1 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) Coatomer_E PF04733.12 001244787.1_49825001_3 - 0.031 13.5 5.8 1.4 8.1 0.8 3.2 2 1 0 3 3 3 0 Coatomer epsilon subunit DUF627 PF04781.10 001244787.1_49825001_3 - 0.056 13.4 3.9 57 3.7 0.0 4.5 3 1 2 5 5 5 0 Protein of unknown function (DUF627) SNAP PF14938.4 001244787.1_49825001_3 - 0.081 12.2 2.0 0.44 9.8 0.2 2.6 2 1 0 2 2 2 0 Soluble NSF attachment protein, SNAP Fis1_TPR_C PF14853.4 001244787.1_49825001_3 - 0.34 10.9 5.6 9.6 6.2 0.0 4.2 4 1 1 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.16 001244787.1_49825001_3 - 5.8 6.9 6.8 20 5.2 0.0 4.8 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain FA_desaturase PF00487.22 001244792.1_49823001_2 - 7.6e-14 52.0 10.5 1e-13 51.6 10.5 1.2 1 0 0 1 1 1 1 Fatty acid desaturase RhoGAP PF00620.25 001204383.1_49824001_2 - 3.8e-41 140.3 0.0 7.3e-41 139.4 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain CRAL_TRIO_2 PF13716.4 001204383.1_49824001_2 - 2.1e-39 134.7 1.6 4e-39 133.8 1.6 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.18 001204383.1_49824001_2 - 2.9e-11 43.2 0.1 5.4e-11 42.3 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain NDK PF00334.17 001204759.1_49822001_2 - 4.3e-55 185.3 0.0 5.1e-55 185.0 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase NACHT PF05729.10 001204769.1_49826001_2 - 9.3e-20 71.1 0.0 2.3e-19 69.8 0.0 1.6 1 0 0 1 1 1 1 NACHT domain LRR_6 PF13516.4 001204769.1_49826001_2 - 9.7e-10 37.6 5.1 0.022 14.6 1.1 5.8 5 0 0 5 5 5 3 Leucine Rich repeat AAA_16 PF13191.4 001204769.1_49826001_2 - 0.013 15.8 0.7 0.055 13.7 0.0 2.5 3 0 0 3 3 3 0 AAA ATPase domain DUF815 PF05673.11 001204769.1_49826001_2 - 0.022 13.8 0.0 0.037 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_22 PF13401.4 001204769.1_49826001_2 - 0.022 14.9 0.0 0.51 10.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain TsaE PF02367.15 001204769.1_49826001_2 - 0.13 12.1 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE LRR_4 PF12799.5 001204769.1_49826001_2 - 0.62 10.4 14.5 0.12 12.7 0.6 5.4 6 1 1 7 7 7 0 Leucine Rich repeats (2 copies) zf-H2C2_2 PF13465.4 001244818.1_49826001_1 - 0.056 13.8 0.7 0.16 12.3 0.7 1.8 1 0 0 1 1 1 0 Zinc-finger double domain zf-H2C2_2 PF13465.4 001244818.1_49826001_2 - 5.8e-83 269.8 92.0 2.5e-08 33.9 0.8 15.2 15 0 0 15 15 15 13 Zinc-finger double domain zf-C2H2 PF00096.24 001244818.1_49826001_2 - 4.4e-45 149.6 117.8 8e-06 25.9 0.3 14.4 16 0 0 16 16 16 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001244818.1_49826001_2 - 6.3e-27 91.8 92.1 0.026 15.2 2.1 12.6 12 0 0 12 12 12 11 C2H2-type zinc finger KRAB PF01352.25 001244818.1_49826001_2 - 5.5e-23 80.2 0.5 1e-22 79.4 0.5 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 001244818.1_49826001_2 - 3e-19 68.4 71.2 0.00091 19.0 0.4 12.1 12 0 0 12 12 12 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001244818.1_49826001_2 - 2.9e-09 36.8 48.6 0.013 15.5 4.3 8.8 6 3 3 9 9 9 6 Zinc ribbon domain zf-C2H2_jaz PF12171.6 001244818.1_49826001_2 - 1.1e-06 28.6 57.1 0.073 13.3 0.6 11.5 12 0 0 12 12 12 6 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 001244818.1_49826001_2 - 0.0021 18.6 44.2 0.13 12.9 0.6 6.1 2 1 3 5 5 5 3 zinc-ribbon family dNK PF01712.17 001244818.1_49826001_2 - 0.03 14.1 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 Deoxynucleoside kinase XPA_N PF01286.16 001244818.1_49826001_2 - 0.66 9.9 49.7 9.1 6.3 0.1 11.2 12 0 0 12 12 12 0 XPA protein N-terminal WD40 PF00400.30 001135964.1_49825001_3 - 2.6e-22 78.6 6.1 2.1e-06 28.2 0.1 6.5 7 0 0 7 7 6 4 WD domain, G-beta repeat TPR_19 PF14559.4 001135964.1_49825001_3 - 5.5e-08 33.1 1.5 0.0034 17.7 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.26 001135964.1_49825001_3 - 1.1e-06 28.0 9.3 0.067 12.9 0.1 4.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.15 001135964.1_49825001_3 - 1.2e-06 28.0 7.8 0.054 13.5 0.4 4.0 3 1 0 3 3 3 2 Tetratricopeptide repeat ANAPC4_WD40 PF12894.5 001135964.1_49825001_3 - 8.2e-06 25.9 0.1 0.0077 16.4 0.2 4.3 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain TPR_14 PF13428.4 001135964.1_49825001_3 - 1.1e-05 25.7 1.6 0.16 12.8 0.3 2.8 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_11 PF13414.4 001135964.1_49825001_3 - 4.2e-05 23.0 0.8 0.00024 20.6 0.5 2.1 2 0 0 2 2 2 1 TPR repeat ANAPC3 PF12895.5 001135964.1_49825001_3 - 0.00013 21.9 4.7 0.00025 21.0 4.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.4 001135964.1_49825001_3 - 0.0002 21.7 0.3 0.34 11.5 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.4 001135964.1_49825001_3 - 0.00024 21.2 1.2 0.93 9.9 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.4 001135964.1_49825001_3 - 0.044 13.8 1.0 2.2 8.4 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.4 001135964.1_49825001_3 - 0.062 13.9 6.0 0.91 10.1 1.7 2.6 2 1 1 3 3 2 0 Tetratricopeptide repeat TPR_8 PF13181.4 001135964.1_49825001_3 - 0.067 13.3 0.5 11 6.3 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Macro PF01661.19 001204770.1_49823001_1 - 8.4e-40 135.4 0.0 1.3e-39 134.8 0.0 1.3 1 0 0 1 1 1 1 Macro domain DUF1108 PF06531.9 001204770.1_49823001_1 - 0.15 12.1 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1108) Med11 PF10280.7 001244823.1_49822001_3 - 2e-12 47.6 1.1 2.8e-12 47.1 1.1 1.2 1 0 0 1 1 1 1 Mediator complex protein Brix PF04427.16 001244824.1_49823001_3 - 2.9e-40 138.3 0.5 5.3e-40 137.5 0.5 1.4 1 0 0 1 1 1 1 Brix domain GSHPx PF00255.17 001137607.1_49823001_2 - 3.5e-37 126.2 0.3 5.3e-37 125.6 0.3 1.3 1 0 0 1 1 1 1 Glutathione peroxidase 7tm_2 PF00002.22 001204902.1_49823001_1 - 6.8e-85 284.1 12.2 6.8e-85 284.1 12.2 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001204902.1_49823001_1 - 1.3e-18 66.9 4.4 2.9e-18 65.8 4.4 1.6 1 0 0 1 1 1 1 Hormone receptor domain Lep_receptor_Ig PF06328.9 001137621.1_49826001_2 - 0.00012 22.0 2.4 0.00035 20.4 0.4 2.7 2 0 0 2 2 2 1 Ig-like C2-type domain IL6Ra-bind PF09240.8 001137621.1_49826001_2 - 0.00081 19.6 1.2 0.0012 19.1 0.2 1.8 2 0 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding Pur_ac_phosph_N PF16656.3 001137621.1_49826001_2 - 0.018 15.4 6.5 0.095 13.1 0.8 3.3 3 0 0 3 3 3 0 Purple acid Phosphatase, N-terminal domain fn3 PF00041.19 001137621.1_49826001_2 - 0.069 13.4 12.7 0.28 11.4 0.9 3.2 4 0 0 4 4 4 0 Fibronectin type III domain CENP-S PF15630.4 001204935.1_49822001_2 - 1.5e-31 108.5 0.2 2.9e-31 107.5 0.2 1.5 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.4 001204935.1_49822001_2 - 4.7e-10 39.4 0.3 7.2e-10 38.8 0.3 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.22 001204935.1_49822001_2 - 0.00014 22.1 0.4 0.00014 22.1 0.4 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.11 001204935.1_49822001_2 - 0.027 14.3 0.2 0.84 9.6 0.0 2.3 2 0 0 2 2 2 0 Bromodomain associated COMMD1_N PF17221.1 001204935.1_49822001_2 - 0.066 13.3 0.8 0.11 12.7 0.8 1.3 1 0 0 1 1 1 0 COMMD1 N-terminal domain MRP-S34 PF16053.3 001244832.1_49823001_1 - 1.6e-48 163.7 0.1 3.1e-48 162.7 0.0 1.5 2 0 0 2 2 2 1 Mitochondrial 28S ribosomal protein S34 NHase_alpha PF02979.14 001244832.1_49823001_1 - 0.11 11.7 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Nitrile hydratase, alpha chain ADH_zinc_N PF00107.24 001244833.1_49824001_1 - 5.6e-26 90.8 0.4 9.1e-26 90.1 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001244833.1_49824001_1 - 1.9e-24 85.5 0.9 1.9e-24 85.5 0.9 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.3 001244833.1_49824001_1 - 0.00051 19.5 0.3 0.0037 16.6 0.2 2.2 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.4 001244833.1_49824001_1 - 0.0015 19.5 0.0 0.0027 18.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.12 001244833.1_49824001_1 - 0.023 14.1 0.2 0.041 13.3 0.2 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Ubiquitin_2 PF14560.4 001205403.1_49822001_2 - 9.3e-27 93.2 0.0 1.5e-26 92.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain CAP_GLY PF01302.23 001205403.1_49822001_2 - 2.3e-24 85.0 0.5 3.6e-24 84.4 0.5 1.3 1 0 0 1 1 1 1 CAP-Gly domain ubiquitin PF00240.21 001205403.1_49822001_2 - 0.05 13.2 0.0 0.36 10.5 0.0 2.3 1 1 0 1 1 1 0 Ubiquitin family RSV_NS2 PF03113.12 001205403.1_49822001_2 - 0.12 12.3 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Respiratory synctial virus non-structural protein NS2 NECFESHC PF16621.3 001205403.1_49822001_2 - 0.4 10.6 2.7 16 5.4 0.5 2.4 2 0 0 2 2 2 0 SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1 SLBP_RNA_bind PF15247.4 001244857.1_49824001_3 - 8.6e-29 99.3 4.2 8.6e-29 99.3 4.2 2.2 3 0 0 3 3 3 1 Histone RNA hairpin-binding protein RNA-binding domain ITI_HC_C PF06668.10 001206349.1_49826001_1 - 1.4e-70 236.7 0.2 2.6e-70 235.8 0.2 1.4 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VIT PF08487.8 001206349.1_49826001_1 - 8.9e-32 109.5 3.8 2e-31 108.4 3.8 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.26 001206349.1_49826001_1 - 7.6e-26 91.3 0.2 1.5e-25 90.3 0.2 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 001206349.1_49826001_1 - 8e-14 52.1 0.1 2.2e-13 50.6 0.1 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 001206349.1_49826001_1 - 3.5e-11 43.1 0.0 5.8e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.7 001206349.1_49826001_1 - 2.1e-05 24.6 0.0 3.7e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus Glyco_hydro_61 PF03443.12 001206349.1_49826001_1 - 0.00031 20.6 0.0 0.00062 19.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 VWA_CoxE PF05762.12 001206349.1_49826001_1 - 0.0031 16.8 0.0 0.0053 16.0 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Adeno_E3_CR2 PF02439.13 001164858.2_49823001_2 - 0.13 12.0 0.3 0.36 10.5 0.3 1.7 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 OAD_gamma PF04277.11 001164858.2_49823001_2 - 1.5 9.3 3.3 2.4e+02 2.3 0.0 2.5 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain LNS2 PF08235.11 001141986.1_49826001_2 - 1.9e-103 344.6 0.0 2.7e-103 344.2 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.12 001141986.1_49826001_2 - 2.2e-43 146.3 0.0 3.6e-43 145.6 0.0 1.4 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.3 001141986.1_49826001_2 - 1.8e-30 105.0 0.0 4.5e-30 103.7 0.0 1.7 2 0 0 2 2 2 1 Lipin/Ned1/Smp2 multi-domain protein middle domain WRNPLPNID PF15017.4 001141986.1_49826001_2 - 0.0077 17.0 0.2 0.035 14.8 0.0 2.2 2 0 0 2 2 2 1 Putative WW-binding domain and destruction box MPC PF03650.11 001244864.1_49822001_3 - 8.1e-33 112.7 0.1 1.3e-32 112.0 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) Ras PF00071.20 001244875.1_49824001_2 - 1e-62 210.4 0.1 1.3e-62 210.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001244875.1_49824001_2 - 2.3e-34 118.1 0.1 3.6e-34 117.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001244875.1_49824001_2 - 5.1e-12 45.5 0.1 7.4e-12 44.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001244875.1_49824001_2 - 1.9e-06 27.8 0.1 3e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 001244875.1_49824001_2 - 0.00073 19.7 0.0 0.0038 17.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.14 001244875.1_49824001_2 - 0.0012 18.7 0.3 0.074 12.8 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001244875.1_49824001_2 - 0.0016 17.9 0.1 0.0034 16.8 0.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001244875.1_49824001_2 - 0.05 12.8 0.0 0.08 12.1 0.0 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_16 PF13191.4 001244875.1_49824001_2 - 0.058 13.6 0.1 0.11 12.8 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.25 001244875.1_49824001_2 - 0.099 13.0 0.1 0.19 12.1 0.1 1.4 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.7 001244875.1_49824001_2 - 0.14 11.7 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.16 001244875.1_49824001_2 - 0.19 11.1 0.1 0.42 10.0 0.1 1.6 1 1 0 1 1 1 0 Ferrous iron transport protein B Memo PF01875.15 001244877.1_49824001_1 - 9.4e-80 267.5 0.0 1.1e-79 267.2 0.0 1.1 1 0 0 1 1 1 1 Memo-like protein zf-C3Hc3H PF13891.4 001244880.1_49825001_1 - 6e-29 100.1 25.6 5.1e-15 55.4 7.4 2.5 2 0 0 2 2 2 2 Potential DNA-binding domain WRC PF08879.8 001244880.1_49825001_1 - 0.64 9.7 7.2 0.9 9.2 0.0 3.3 3 0 0 3 3 3 0 WRC SOSSC PF15925.3 001244886.1_49825001_1 - 5.2e-21 75.7 0.5 1.5e-20 74.3 0.5 1.8 1 1 0 1 1 1 1 SOSS complex subunit C Sacchrp_dh_C PF16653.3 001244900.1_49826001_1 - 7.3e-85 285.1 0.0 1.2e-84 284.4 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain AlaDh_PNT_N PF05222.13 001244900.1_49826001_1 - 1.3e-25 90.2 0.0 3.1e-25 88.9 0.0 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain Sacchrp_dh_NADP PF03435.16 001244900.1_49826001_1 - 2.3e-22 79.5 0.0 4e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_C PF01262.19 001244900.1_49826001_1 - 1.3e-07 31.0 0.0 4.6e-05 22.7 0.0 3.1 2 1 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain DUF2325 PF10087.7 001244900.1_49826001_1 - 0.0014 18.6 0.0 0.0029 17.6 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2325) Shikimate_DH PF01488.18 001244900.1_49826001_1 - 0.035 14.0 0.0 0.074 13.0 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.4 001244900.1_49826001_1 - 0.17 11.7 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding PDZ PF00595.22 001206404.1_49829001_2 - 3.3e-44 149.0 6.9 5e-15 55.5 0.2 3.4 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001206404.1_49829001_2 - 1.4e-15 57.2 1.5 0.00094 19.3 0.0 3.4 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.19 001206404.1_49829001_2 - 1.8e-11 43.9 0.0 4.3e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.15 001206404.1_49829001_2 - 4.3e-08 32.6 0.2 3.2e-07 29.8 0.0 2.6 4 0 0 4 4 4 1 Variant SH3 domain SH3_1 PF00018.26 001206404.1_49829001_2 - 0.00074 18.9 0.0 0.0056 16.1 0.0 2.5 2 0 0 2 2 2 1 SH3 domain RRM_1 PF00076.20 001246197.1_49824001_1 - 2.5e-24 84.8 0.1 4.7e-24 83.9 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001246197.1_49824001_1 - 0.0016 18.4 0.0 0.0032 17.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.3 001246197.1_49824001_1 - 0.0045 16.7 0.0 0.0087 15.8 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif LSM PF01423.20 001244928.1_49821001_1 - 1e-19 69.9 0.2 1.4e-19 69.4 0.2 1.2 1 0 0 1 1 1 1 LSM domain RRM_1 PF00076.20 001244930.1_49825001_2 - 7.4e-53 176.1 0.1 6.3e-19 67.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M PF11532.6 001244930.1_49825001_2 - 3.9e-18 65.2 9.9 8.3e-18 64.2 9.9 1.6 1 0 0 1 1 1 1 Heterogeneous nuclear ribonucleoprotein M Limkain-b1 PF11608.6 001244930.1_49825001_2 - 9.6e-05 22.2 0.2 0.0091 15.9 0.0 2.6 2 1 0 2 2 2 1 Limkain b1 RRM_5 PF13893.4 001244930.1_49825001_2 - 0.00018 21.0 0.5 0.15 11.6 0.0 3.2 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Collagen_mid PF15984.3 001244930.1_49825001_2 - 0.00018 21.2 0.0 0.00018 21.2 0.0 2.6 2 1 1 3 3 3 1 Bacterial collagen, middle region RRM_occluded PF16842.3 001244930.1_49825001_2 - 0.002 17.8 0.0 0.12 12.1 0.0 2.4 2 0 0 2 2 2 1 Occluded RNA-recognition motif Transcrip_reg PF01709.18 001244958.1_49823001_2 - 3.5e-64 216.4 0.0 4.1e-64 216.1 0.0 1.1 1 0 0 1 1 1 1 Transcriptional regulator T-box PF00907.20 001246248.1_49826001_2 - 1.7e-85 285.7 0.1 2.2e-85 285.4 0.1 1.1 1 0 0 1 1 1 1 T-box TBX PF12598.6 001246248.1_49826001_2 - 1e-23 83.8 5.1 1e-23 83.8 5.1 2.4 3 0 0 3 3 3 1 T-box transcription factor T-box PF00907.20 001246249.1_49824001_1 - 8.3e-82 273.7 0.3 1.6e-81 272.8 0.1 1.5 2 0 0 2 2 2 1 T-box Thioredoxin_7 PF13899.4 001244968.1_49822001_1 - 4.5e-24 84.3 0.0 8e-24 83.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.4 001244968.1_49822001_1 - 0.028 14.7 0.1 0.18 12.1 0.1 2.0 1 1 0 1 1 1 0 Thioredoxin-like domain DUF2490 PF10677.7 001244968.1_49822001_1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2490) FoP_duplication PF13865.4 001243268.1_49823001_2 - 1.7e-22 79.6 9.6 1.7e-22 79.6 9.6 3.9 2 1 1 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 Sbi-IV PF11621.6 001243268.1_49823001_2 - 1.7 9.0 9.2 13 6.1 0.0 3.9 2 2 2 4 4 4 0 C3 binding domain 4 of IgG-bind protein SBI MFS_1 PF07690.14 001142846.1_49824001_1 - 3.5e-29 101.7 54.4 6.4e-25 87.7 32.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily EF-hand_6 PF13405.4 001244975.1_49823001_3 - 3.6e-18 63.8 0.4 0.0011 18.5 0.0 5.0 5 1 1 6 6 6 4 EF-hand domain EF-hand_7 PF13499.4 001244975.1_49823001_3 - 8.2e-18 64.5 0.1 3.3e-08 33.8 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 001244975.1_49823001_3 - 1.1e-16 58.9 0.1 0.00033 19.9 0.0 5.1 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.4 001244975.1_49823001_3 - 1.6e-08 33.5 0.7 0.14 11.6 0.1 4.4 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.4 001244975.1_49823001_3 - 2.8e-08 33.3 0.8 0.00028 20.5 0.0 3.9 3 2 0 4 4 4 2 EF-hand domain pair AMP-binding PF00501.26 001243022.1_49825001_2 - 5.6e-81 272.1 0.0 7.2e-81 271.8 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001243022.1_49825001_2 - 6.4e-24 84.6 0.8 1.4e-23 83.5 0.8 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain UFC1 PF08694.9 001243022.1_49825001_2 - 0.051 13.1 0.0 0.091 12.3 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 EF-hand_6 PF13405.4 001244976.1_49823001_2 - 2.5e-15 54.9 0.0 0.0011 18.7 0.0 4.1 5 0 0 5 5 5 3 EF-hand domain EF-hand_1 PF00036.30 001244976.1_49823001_2 - 1.1e-14 52.6 0.0 0.0003 20.0 0.0 4.4 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.4 001244976.1_49823001_2 - 5.4e-13 49.1 0.2 3e-08 33.9 0.1 2.7 2 1 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 001244976.1_49823001_2 - 1.8e-07 30.2 0.5 0.13 11.7 0.1 3.6 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.4 001244976.1_49823001_2 - 2.2e-07 30.4 0.6 0.00025 20.6 0.0 3.3 3 1 0 3 3 3 2 EF-hand domain pair V-SNARE_C PF12352.6 214437.1_49822001_3 - 1.8e-20 72.8 7.4 1.8e-20 72.8 7.4 2.3 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.13 214437.1_49822001_3 - 9.7e-18 64.2 0.2 9.7e-18 64.2 0.2 2.2 2 1 1 3 3 3 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.11 214437.1_49822001_3 - 5.6e-07 29.2 0.9 1.9e-06 27.6 1.1 1.8 2 0 0 2 2 2 1 Sec20 Laminin_II PF06009.10 214437.1_49822001_3 - 7e-05 22.7 2.2 0.1 12.5 1.0 2.6 2 1 1 3 3 3 2 Laminin Domain II YqjK PF13997.4 214437.1_49822001_3 - 0.0013 18.8 1.5 1.8 8.7 0.4 2.5 2 0 0 2 2 2 2 YqjK-like protein Fusion_gly PF00523.16 214437.1_49822001_3 - 0.042 12.0 1.6 0.084 11.0 1.7 1.3 1 1 0 1 1 1 0 Fusion glycoprotein F0 DUF745 PF05335.11 214437.1_49822001_3 - 0.15 11.6 3.5 1.1 8.9 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) KxDL PF10241.7 214437.1_49822001_3 - 0.26 11.4 8.5 2.7 8.2 0.4 3.3 2 2 1 3 3 3 0 Uncharacterized conserved protein OmpH PF03938.12 214437.1_49822001_3 - 0.29 11.0 2.6 0.95 9.3 0.1 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Suppressor_APC PF11414.6 214437.1_49822001_3 - 0.54 10.2 4.4 5 7.1 1.9 2.9 2 2 1 3 3 3 0 Adenomatous polyposis coli tumour suppressor protein Syntaxin-6_N PF09177.9 214437.1_49822001_3 - 1.1 9.7 6.9 8.7 6.9 2.3 2.8 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Exonuc_VII_L PF02601.13 214437.1_49822001_3 - 2.3 7.6 8.4 8.8 5.7 8.4 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit CorA PF01544.16 214437.1_49822001_3 - 4.5 6.4 8.8 5 6.2 0.3 2.4 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein CCDC-167 PF15188.4 214437.1_49822001_3 - 7 6.9 11.3 7.3 6.9 2.8 3.0 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 EF-hand_7 PF13499.4 001244977.1_49823001_2 - 2.7e-15 56.4 5.4 2.9e-08 34.0 0.1 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001244977.1_49823001_2 - 1.2e-12 46.5 4.3 0.00095 18.8 0.0 3.8 3 1 2 5 5 5 3 EF-hand domain EF-hand_1 PF00036.30 001244977.1_49823001_2 - 3e-12 45.0 0.2 0.00026 20.2 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.4 001244977.1_49823001_2 - 2.4e-06 27.1 0.6 0.00016 21.2 0.0 3.0 2 2 1 4 4 4 1 EF-hand domain pair EF-hand_5 PF13202.4 001244977.1_49823001_2 - 6.3e-05 22.2 0.4 0.12 11.8 0.1 3.5 3 0 0 3 3 3 1 EF hand Glyco_hydro_56 PF01630.16 214440.1_49823001_2 - 2.7e-136 453.8 0.0 3.3e-136 453.6 0.0 1.1 1 0 0 1 1 1 1 Hyaluronidase EGF PF00008.25 214440.1_49823001_2 - 0.049 13.8 6.2 0.52 10.5 0.4 2.6 2 0 0 2 2 2 0 EGF-like domain PIH1 PF08190.10 001244978.1_49823001_3 - 5.8e-49 167.6 0.0 1.1e-37 130.5 0.0 2.0 1 1 1 2 2 2 2 pre-RNA processing PIH1/Nop17 MAM PF00629.21 001244983.1_49822001_1 - 5.1e-30 104.3 0.0 6.9e-30 103.9 0.0 1.2 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu PPR_2 PF13041.4 001243030.1_49828001_2 - 6.1e-19 67.8 2.0 1e-06 28.7 0.1 5.5 5 0 0 5 5 5 3 PPR repeat family PPR_3 PF13812.4 001243030.1_49828001_2 - 3.3e-11 43.0 1.9 1.4e-06 28.1 0.1 4.1 3 2 2 5 5 5 2 Pentatricopeptide repeat domain PPR_long PF17177.2 001243030.1_49828001_2 - 2e-05 23.9 0.5 0.00026 20.3 0.0 2.5 1 1 1 2 2 2 1 Pentacotripeptide-repeat region of PROPR PPR_1 PF12854.5 001243030.1_49828001_2 - 0.00075 19.0 0.0 4.5 7.0 0.0 4.2 4 0 0 4 4 4 2 PPR repeat DUF892 PF05974.10 001243030.1_49828001_2 - 0.16 11.8 0.5 0.41 10.5 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF892) PPR PF01535.18 001243030.1_49828001_2 - 4.2 7.7 7.5 29 5.1 0.0 5.5 8 0 0 8 8 8 0 PPR repeat Septin PF00735.16 001244989.1_49824001_3 - 1.5e-120 401.5 0.0 2.1e-120 401.1 0.0 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 001244989.1_49824001_3 - 3.2e-08 33.5 0.0 6.7e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001244989.1_49824001_3 - 1.3e-07 31.5 0.7 2.5e-06 27.4 0.0 2.4 3 0 0 3 3 3 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001244989.1_49824001_3 - 1.4e-05 24.6 0.9 0.037 13.4 0.0 2.5 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain AAA_23 PF13476.4 001244989.1_49824001_3 - 0.0034 17.8 0.0 0.035 14.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain AIG1 PF04548.14 001244989.1_49824001_3 - 0.0049 16.1 0.0 0.011 14.9 0.0 1.6 1 0 0 1 1 1 1 AIG1 family Roc PF08477.11 001244989.1_49824001_3 - 0.032 14.3 0.0 0.061 13.4 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.4 001244989.1_49824001_3 - 0.032 14.4 0.7 0.14 12.3 0.0 2.4 3 1 0 3 3 3 0 AAA domain AAA_29 PF13555.4 001244989.1_49824001_3 - 0.039 13.5 0.0 0.076 12.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.4 001244989.1_49824001_3 - 0.04 14.2 0.8 0.13 12.5 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain Ras PF00071.20 001244989.1_49824001_3 - 0.047 13.1 0.0 0.098 12.1 0.0 1.5 1 0 0 1 1 1 0 Ras family Pet20 PF08692.8 001244989.1_49824001_3 - 0.05 14.2 0.0 0.22 12.1 0.0 1.9 2 0 0 2 2 2 0 Mitochondrial protein Pet20 Dynamin_N PF00350.21 001244989.1_49824001_3 - 0.07 13.0 2.5 8.8 6.2 0.1 3.1 2 1 1 3 3 3 0 Dynamin family ABC_tran PF00005.25 001244989.1_49824001_3 - 0.088 13.2 0.5 0.2 12.0 0.0 1.8 2 0 0 2 2 2 0 ABC transporter IIGP PF05049.11 001244989.1_49824001_3 - 0.38 9.6 0.0 0.38 9.6 0.0 1.8 3 0 0 3 3 3 0 Interferon-inducible GTPase (IIGP) SUIM_assoc PF16619.3 001244989.1_49824001_3 - 1.2 9.1 5.4 3.9 7.5 5.4 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 PDZ PF00595.22 001244991.1_49825001_2 - 2e-21 76.0 0.1 3.1e-21 75.4 0.1 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001244991.1_49825001_2 - 2.9e-08 33.8 0.1 4.6e-08 33.1 0.1 1.2 1 0 0 1 1 1 1 PDZ domain Trypsin PF00089.24 001143693.1_49822001_2 - 1.5e-60 204.6 0.0 2e-60 204.2 0.0 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001143693.1_49822001_2 - 1.2e-05 26.0 0.1 3.1e-05 24.8 0.1 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001143693.1_49822001_2 - 0.0021 18.3 0.0 0.0036 17.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Acyltransferase PF01553.19 001143701.1_49823001_2 - 9.2e-18 64.0 0.0 1.5e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.3 001143701.1_49823001_2 - 4e-15 55.6 0.4 1e-14 54.3 0.4 1.8 1 0 0 1 1 1 1 Acyltransferase C-terminus NAC PF01849.16 001244998.1_49822001_2 - 2.6e-26 91.3 0.2 4.6e-26 90.5 0.2 1.4 1 0 0 1 1 1 1 NAC domain Acyltransf_C PF16076.3 001143697.1_49823001_2 - 3.7e-26 91.0 0.1 6.7e-26 90.1 0.1 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.19 001143697.1_49823001_2 - 2.3e-14 53.0 0.0 3.8e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase FGGY_N PF00370.19 001143708.1_49824001_2 - 1.2e-88 296.7 0.0 1.7e-88 296.2 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.14 001143708.1_49824001_2 - 1.3e-65 220.7 0.1 2.3e-65 219.9 0.1 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Trypsin PF00089.24 001143709.1_49823001_2 - 4.1e-55 186.9 0.2 4.8e-55 186.6 0.2 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 001143709.1_49823001_2 - 0.00013 22.2 0.0 0.00025 21.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 001143709.1_49823001_2 - 0.00021 22.0 0.0 0.00034 21.4 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain AAA PF00004.27 001245008.1_49825001_3 - 4.7e-40 136.9 0.0 1.4e-39 135.4 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 001245008.1_49825001_3 - 0.00024 21.2 0.0 0.0074 16.4 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.12 001245008.1_49825001_3 - 0.0013 18.6 0.0 0.0045 16.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 001245008.1_49825001_3 - 0.0051 17.1 0.1 0.045 14.0 0.1 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.12 001245008.1_49825001_3 - 0.0097 15.9 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.11 001245008.1_49825001_3 - 0.011 14.8 0.0 0.026 13.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.4 001245008.1_49825001_3 - 0.025 14.6 0.0 0.046 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.10 001245008.1_49825001_3 - 0.028 13.6 0.0 0.051 12.7 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_28 PF13521.4 001245008.1_49825001_3 - 0.029 14.5 0.0 0.047 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.4 001245008.1_49825001_3 - 0.033 14.6 0.0 0.074 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.4 001245008.1_49825001_3 - 0.1 12.6 0.0 0.31 11.0 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.15 001245008.1_49825001_3 - 0.1 12.2 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.19 001245008.1_49825001_3 - 0.12 11.6 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MGTL PF17059.3 001143710.1_49822001_1 - 0.67 9.7 8.9 0.073 12.7 3.7 2.3 2 0 0 2 2 2 0 MgtA leader peptide Trypsin PF00089.24 001143710.1_49822001_3 - 5.5e-66 222.4 0.3 6.3e-66 222.2 0.3 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001143710.1_49822001_3 - 1e-06 29.6 0.0 1.7e-06 28.9 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001143710.1_49822001_3 - 0.019 15.2 0.0 0.035 14.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Peptidase_S24 PF00717.21 001245014.1_49822001_2 - 6.1e-15 54.8 0.0 1.2e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.7 001245014.1_49822001_2 - 4.7e-07 29.5 0.0 1.3e-05 24.9 0.0 2.4 1 1 1 2 2 2 1 Signal peptidase, peptidase S26 Pkinase PF00069.23 001143719.1_49826001_1 - 3.2e-66 223.2 0.0 4.8e-66 222.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001143719.1_49826001_1 - 9.3e-29 100.4 0.0 1.3e-28 99.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001143719.1_49826001_1 - 5.6e-06 25.7 0.0 9.7e-06 24.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RRN7 PF11781.6 001143719.1_49826001_1 - 9.1e-05 21.9 0.1 0.00022 20.7 0.1 1.7 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 APH PF01636.21 001143719.1_49826001_1 - 0.02 14.7 0.4 0.064 13.0 0.0 2.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family Trypsin PF00089.24 001243643.1_49826001_2 - 4.8e-39 134.3 0.0 7.8e-39 133.6 0.0 1.3 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 001243643.1_49826001_2 - 3.7e-24 85.0 0.0 8.3e-24 83.9 0.0 1.6 1 0 0 1 1 1 1 CUB domain Sushi PF00084.18 001243643.1_49826001_2 - 1.7e-13 50.9 14.2 1.7e-08 34.8 0.6 3.5 4 0 0 4 4 4 2 Sushi repeat (SCR repeat) EGF PF00008.25 001243643.1_49826001_2 - 1.8e-06 28.0 5.4 1.8e-06 28.0 5.4 4.1 4 0 0 4 4 4 1 EGF-like domain hEGF PF12661.5 001243643.1_49826001_2 - 0.002 18.6 1.6 0.002 18.6 1.6 4.5 4 0 0 4 4 4 1 Human growth factor-like EGF DUF1986 PF09342.9 001243643.1_49826001_2 - 0.048 13.9 0.1 0.19 12.0 0.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) cEGF PF12662.5 001243643.1_49826001_2 - 0.56 10.1 10.5 0.035 13.9 1.4 4.0 4 0 0 4 4 4 0 Complement Clr-like EGF-like Adaptin_N PF01602.18 001243183.1_49827001_2 - 1.8e-162 541.4 13.9 2.3e-162 541.1 13.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.5 001243183.1_49827001_2 - 1.7e-67 226.4 14.2 1.6e-65 219.9 1.6 3.9 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.8 001243183.1_49827001_2 - 9.3e-38 128.6 0.1 2.6e-37 127.2 0.1 1.8 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.4 001243183.1_49827001_2 - 3.7e-21 75.2 4.9 1.6e-07 31.5 0.0 6.4 3 2 3 7 7 7 5 HEAT repeats HEAT PF02985.20 001243183.1_49827001_2 - 2.7e-12 45.6 8.9 0.0074 16.3 0.1 7.5 7 0 0 7 7 7 3 HEAT repeat Alpha_adaptinC2 PF02883.18 001243183.1_49827001_2 - 1.2e-10 41.5 1.8 1.2e-10 41.5 0.4 1.8 2 0 0 2 2 2 1 Adaptin C-terminal domain Arm PF00514.21 001243183.1_49827001_2 - 7.8e-08 32.0 2.2 0.021 14.7 0.0 5.3 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Cnd3 PF12719.5 001243183.1_49827001_2 - 9.2e-08 31.5 2.4 1.3e-05 24.5 0.2 2.6 2 0 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.7 001243183.1_49827001_2 - 0.00023 21.1 5.3 0.85 9.7 0.0 5.2 2 2 1 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.6 001243183.1_49827001_2 - 0.00025 20.6 2.0 1.3 8.4 0.1 4.1 2 2 0 2 2 2 2 CLASP N terminal Arm_2 PF04826.11 001243183.1_49827001_2 - 0.0028 17.0 1.3 0.044 13.1 0.2 2.6 1 1 1 2 2 2 1 Armadillo-like HEAT_EZ PF13513.4 001243183.1_49827001_2 - 0.016 15.5 8.2 7.4 7.0 0.0 6.4 7 1 1 8 8 8 0 HEAT-like repeat Sec7_N PF12783.5 001243183.1_49827001_2 - 0.048 13.5 6.0 0.064 13.1 0.2 3.8 5 1 1 6 6 6 0 Guanine nucleotide exchange factor in Golgi transport N-terminal SIX1_SD PF16878.3 001244614.1_49829001_1 - 2.9e-45 153.2 0.1 4.9e-44 149.2 0.0 2.5 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeobox PF00046.27 001244614.1_49829001_1 - 1.5e-13 50.2 1.2 3.1e-13 49.2 1.2 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001244614.1_49829001_1 - 4.7e-09 35.9 0.4 1e-08 34.8 0.4 1.6 1 0 0 1 1 1 1 Homeobox KN domain RSN1_7TM PF02714.13 001243189.1_49827001_3 - 3.5e-54 183.9 19.7 8.5e-54 182.6 19.7 1.7 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.4 001243189.1_49827001_3 - 4.6e-42 144.1 0.1 6.5e-42 143.6 0.1 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.4 001243189.1_49827001_3 - 2.5e-20 72.7 1.8 2.5e-20 72.7 1.8 4.7 5 1 1 6 6 6 2 Late exocytosis, associated with Golgi transport RRM_1 PF00076.20 001243189.1_49827001_3 - 0.0014 18.2 0.0 1 9.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Calreticulin PF00262.16 001243207.1_49827001_3 - 5.2e-159 528.8 3.9 8.9e-159 528.1 3.9 1.3 1 0 0 1 1 1 1 Calreticulin family CDC45 PF02724.12 001243207.1_49827001_3 - 1.5 6.9 7.2 2.2 6.4 7.2 1.1 1 0 0 1 1 1 0 CDC45-like protein IRS PF02174.15 001243209.1_49827001_2 - 2.6e-24 84.8 0.1 5.1e-24 83.9 0.1 1.4 1 0 0 1 1 1 1 PTB domain (IRS-1 type) TM2 PF05154.14 001244627.1_49828001_1 - 3.2e-14 52.8 12.2 7e-14 51.8 12.2 1.6 1 0 0 1 1 1 1 TM2 domain PD-C2-AF1 PF09310.8 001244060.1_49823001_3 - 1e-137 457.3 16.4 1.3e-137 457.1 16.4 1.1 1 0 0 1 1 1 1 POU domain, class 2, associating factor 1 Ras PF00071.20 001243291.1_49826001_3 - 2.5e-58 196.1 0.5 3.4e-58 195.7 0.5 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001243291.1_49826001_3 - 1e-34 119.2 0.2 2.4e-34 118.0 0.2 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001243291.1_49826001_3 - 2.2e-16 59.7 0.1 3.2e-16 59.1 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001243291.1_49826001_3 - 7e-05 22.8 0.1 0.00012 22.0 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001243291.1_49826001_3 - 7.2e-05 22.3 0.4 0.00017 21.1 0.2 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001243291.1_49826001_3 - 0.00053 19.3 0.1 0.00086 18.6 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.14 001243291.1_49826001_3 - 0.0062 16.3 0.8 0.22 11.3 0.1 2.2 1 1 1 2 2 2 1 Protein of unknown function, DUF258 PduV-EutP PF10662.7 001243291.1_49826001_3 - 0.035 13.7 0.2 0.22 11.1 0.2 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.4 001243291.1_49826001_3 - 0.07 13.4 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.4 001243291.1_49826001_3 - 0.12 12.0 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.4 001243291.1_49826001_3 - 0.14 12.3 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.8 001243291.1_49826001_3 - 0.22 10.8 1.2 0.23 10.7 0.0 1.5 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Trypsin PF00089.24 001001911.1_49822001_1 - 1.3e-66 224.4 0.0 1.7e-66 224.1 0.0 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001001911.1_49822001_1 - 2e-05 25.4 0.0 3.5e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001001911.1_49822001_1 - 3.3e-05 24.1 0.2 0.00053 20.2 0.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1986) HRM PF02793.20 001001911.1_49822001_1 - 0.015 15.5 4.9 0.045 13.9 0.7 3.0 3 0 0 3 3 3 0 Hormone receptor domain MtrG PF04210.11 001243301.1_49827001_3 - 0.11 12.3 0.1 0.25 11.1 0.1 1.6 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G YtxH PF12732.5 001243301.1_49827001_3 - 0.17 12.4 11.1 0.029 14.8 3.9 3.2 3 1 0 3 3 3 0 YtxH-like protein MoCF_biosynth PF00994.22 001243302.1_49827001_1 - 1.9e-68 228.5 0.0 1e-40 138.6 0.0 2.3 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.15 001243302.1_49827001_1 - 1e-32 112.5 0.1 2.1e-32 111.5 0.1 1.5 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.13 001243302.1_49827001_1 - 2.9e-23 81.7 0.0 6.6e-23 80.5 0.0 1.7 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) Mito_fiss_reg PF05308.9 001243302.1_49827001_1 - 2.6 7.9 7.5 2.7 7.9 0.7 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator MHC_I PF00129.16 001004035.1_49823001_1 - 4.6e-14 52.2 0.0 5.8e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_2 PF14586.4 001004035.1_49823001_1 - 0.0048 16.7 0.2 0.0066 16.2 0.2 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2 LRR_8 PF13855.4 001243339.1_49824001_3 - 3.5e-35 119.4 31.8 4e-11 42.4 4.0 6.6 5 2 1 6 6 6 5 Leucine rich repeat LRR_4 PF12799.5 001243339.1_49824001_3 - 4.5e-19 68.0 35.1 1.7e-06 28.1 0.1 6.5 2 1 6 8 8 8 7 Leucine Rich repeats (2 copies) LRRNT PF01462.16 001243339.1_49824001_3 - 3.2e-08 32.9 3.0 3.2e-08 32.9 3.0 2.5 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 001243339.1_49824001_3 - 1.7e-07 30.8 8.6 0.017 14.5 0.5 3.8 1 1 3 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.31 001243339.1_49824001_3 - 4.3e-06 26.3 24.0 11 6.8 0.4 9.5 8 3 0 8 8 8 1 Leucine Rich Repeat LRR_6 PF13516.4 001243339.1_49824001_3 - 6.9e-06 25.6 24.6 1.5 8.9 0.0 9.2 10 0 0 10 10 10 3 Leucine Rich repeat LRR_5 PF13306.4 001243339.1_49824001_3 - 1.6e-05 24.7 2.3 0.02 14.7 0.1 3.1 1 1 1 3 3 3 3 Leucine rich repeats (6 copies) Snf7 PF03357.19 001243360.1_49825001_2 - 1.6e-11 44.0 16.4 2.4e-11 43.4 16.4 1.1 1 0 0 1 1 1 1 Snf7 Ist1 PF03398.12 001243360.1_49825001_2 - 0.083 12.7 9.2 0.14 11.9 9.2 1.3 1 0 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway Baculo_PEP_C PF04513.10 001243360.1_49825001_2 - 0.67 9.9 4.3 0.88 9.5 3.1 1.8 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CUE PF02845.14 001243919.1_49826001_1 - 8.4e-14 50.8 0.2 1.5e-13 50.0 0.2 1.4 1 0 0 1 1 1 1 CUE domain CD225 PF04505.10 001304279.1_49823001_1 - 4.5e-10 39.4 2.3 1.2e-09 38.0 2.3 1.7 1 0 0 1 1 1 1 Interferon-induced transmembrane protein DUF1191 PF06697.10 001304279.1_49823001_1 - 0.1 11.7 0.1 0.14 11.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) CCDC-167 PF15188.4 001243364.1_49822001_2 - 1.5e-31 108.4 2.8 2.2e-31 107.9 2.8 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 167 IncA PF04156.12 001243364.1_49822001_2 - 0.039 13.6 4.1 0.054 13.1 4.1 1.2 1 0 0 1 1 1 0 IncA protein Cnn_1N PF07989.9 001243364.1_49822001_2 - 0.07 13.1 3.9 0.14 12.1 3.9 1.5 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 DUF2208 PF09973.7 001243364.1_49822001_2 - 0.082 12.4 0.0 0.098 12.1 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) Shugoshin_N PF07558.9 001243364.1_49822001_2 - 0.21 11.4 7.6 0.062 13.0 4.4 1.8 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region TMEM61 PF15105.4 001243365.1_49823001_2 - 2e-106 353.8 5.6 2.6e-106 353.4 5.6 1.2 1 0 0 1 1 1 1 TMEM61 protein family TMEM51 PF15345.4 001243365.1_49823001_2 - 0.0046 16.7 0.0 0.01 15.6 0.0 1.5 1 1 0 1 1 1 1 Transmembrane protein 51 MIS13 PF08202.9 001243366.1_49824001_2 - 1.1e-56 192.3 8.0 1.7e-56 191.6 8.0 1.2 1 0 0 1 1 1 1 Mis12-Mtw1 protein family CK2S PF15011.4 001243366.1_49824001_2 - 0.17 11.6 5.7 1.5 8.5 3.1 2.2 1 1 1 2 2 2 0 Casein Kinase 2 substrate TBCC_N PF16752.3 001243366.1_49824001_2 - 6.4 7.1 10.7 9.4 6.6 1.0 3.0 1 1 1 3 3 3 0 Tubulin-specific chaperone C N-terminal domain TFCD_C PF12612.6 001244105.1_49828001_1 - 3e-67 226.0 0.1 1.8e-66 223.5 0.0 2.4 3 0 0 3 3 3 1 Tubulin folding cofactor D C terminal HEAT_EZ PF13513.4 001244105.1_49828001_1 - 1.1e-07 32.0 31.1 0.055 13.8 1.0 9.2 9 1 1 10 10 10 4 HEAT-like repeat HEAT_2 PF13646.4 001244105.1_49828001_1 - 1e-05 25.7 7.3 0.018 15.3 0.4 5.5 5 0 0 5 5 5 2 HEAT repeats HEAT PF02985.20 001244105.1_49828001_1 - 0.0028 17.6 27.7 0.41 10.9 0.0 10.5 11 0 0 11 11 11 2 HEAT repeat DREV PF05219.10 001243367.1_49824001_2 - 6.2e-139 461.4 0.1 7.4e-139 461.1 0.1 1.1 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_23 PF13489.4 001243367.1_49824001_2 - 4.4e-10 39.6 0.0 7.4e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001243367.1_49824001_2 - 8.8e-08 32.7 0.0 1.5e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001243367.1_49824001_2 - 4.8e-06 27.0 0.0 8.9e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 001243367.1_49824001_2 - 3.4e-05 24.4 0.0 6.5e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 001243367.1_49824001_2 - 0.16 11.4 0.0 18 4.7 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase small domain Flavoprotein PF02441.17 001243368.1_49823001_1 - 1.9e-49 167.3 0.0 2.4e-49 167.0 0.0 1.1 1 0 0 1 1 1 1 Flavoprotein ABC_membrane PF00664.21 001308246.1_49828001_1 - 8e-175 579.9 30.0 4.9e-94 314.9 9.4 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001308246.1_49828001_1 - 4.5e-76 253.8 0.5 3.4e-37 127.9 0.1 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 001308246.1_49828001_1 - 1.7e-16 60.2 4.4 2.4e-07 30.3 0.4 3.9 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 001308246.1_49828001_1 - 3e-11 43.9 0.6 0.00035 20.9 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.7 001308246.1_49828001_1 - 6.1e-11 41.6 0.2 6.8e-05 21.7 0.0 3.2 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_22 PF13401.4 001308246.1_49828001_1 - 1.1e-08 35.3 0.7 0.0043 17.2 0.1 3.1 2 2 0 2 2 2 2 AAA domain Zeta_toxin PF06414.10 001308246.1_49828001_1 - 7.8e-08 31.7 1.4 0.00041 19.6 0.0 3.3 4 0 0 4 4 4 2 Zeta toxin DUF258 PF03193.14 001308246.1_49828001_1 - 1.5e-07 31.3 0.1 0.024 14.4 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 G-alpha PF00503.18 001308246.1_49828001_1 - 3.1e-07 29.8 0.0 0.0032 16.5 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit AAA_29 PF13555.4 001308246.1_49828001_1 - 2.4e-06 27.0 1.1 0.037 13.6 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Rad17 PF03215.13 001308246.1_49828001_1 - 2.9e-06 26.4 0.1 0.0069 15.2 0.1 2.3 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA PF00004.27 001308246.1_49828001_1 - 5.1e-06 26.8 3.2 0.16 12.3 0.1 4.2 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 001308246.1_49828001_1 - 8e-06 25.8 0.7 0.15 12.0 0.0 3.6 4 0 0 4 4 4 2 AAA domain (dynein-related subfamily) SbcCD_C PF13558.4 001308246.1_49828001_1 - 8.6e-05 22.6 3.9 0.19 11.9 0.4 3.9 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.4 001308246.1_49828001_1 - 9e-05 22.1 0.0 0.24 10.8 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain PRK PF00485.16 001308246.1_49828001_1 - 0.00034 20.3 0.0 0.69 9.5 0.0 2.6 2 1 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family DUF815 PF05673.11 001308246.1_49828001_1 - 0.00047 19.3 0.2 0.29 10.1 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) APS_kinase PF01583.18 001308246.1_49828001_1 - 0.00062 19.5 0.2 0.37 10.6 0.0 2.5 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_30 PF13604.4 001308246.1_49828001_1 - 0.00072 19.2 2.2 0.4 10.2 0.1 3.1 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.20 001308246.1_49828001_1 - 0.0013 19.0 0.0 4.4 7.6 0.0 3.4 4 0 0 4 4 2 0 RNA helicase AAA_28 PF13521.4 001308246.1_49828001_1 - 0.0014 18.7 0.2 7.3 6.7 0.1 3.4 2 1 0 3 3 3 0 AAA domain AAA_21 PF13304.4 001308246.1_49828001_1 - 0.0016 18.2 0.0 9.4 5.8 0.0 4.1 3 1 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system ATP-synt_ab PF00006.23 001308246.1_49828001_1 - 0.0017 17.9 1.2 1.9 7.9 0.0 3.1 2 1 0 3 3 3 1 ATP synthase alpha/beta family, nucleotide-binding domain DUF87 PF01935.15 001308246.1_49828001_1 - 0.0026 17.7 1.3 2.6 7.9 0.0 2.9 3 0 0 3 3 2 2 Domain of unknown function DUF87 AAA_24 PF13479.4 001308246.1_49828001_1 - 0.0028 17.3 0.0 0.88 9.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.4 001308246.1_49828001_1 - 0.0037 17.2 0.1 1.1 9.1 0.0 3.5 4 0 0 4 4 3 1 AAA domain IstB_IS21 PF01695.15 001308246.1_49828001_1 - 0.0041 16.8 1.2 22 4.6 0.0 4.1 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_33 PF13671.4 001308246.1_49828001_1 - 0.006 16.6 0.0 5.3 7.1 0.0 3.2 3 0 0 3 3 2 0 AAA domain tRNA_lig_kinase PF08303.9 001308246.1_49828001_1 - 0.011 15.7 0.0 6 6.8 0.0 2.6 2 0 0 2 2 2 0 tRNA ligase kinase domain NACHT PF05729.10 001308246.1_49828001_1 - 0.018 14.8 0.0 6.7 6.5 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.4 001308246.1_49828001_1 - 0.021 15.2 0.0 6.4 7.2 0.0 2.8 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.19 001308246.1_49828001_1 - 0.029 13.6 0.0 4.9 6.3 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.4 001308246.1_49828001_1 - 0.03 13.8 0.0 5.6 6.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF2207 PF09972.7 001308246.1_49828001_1 - 0.034 12.8 0.2 0.034 12.8 0.2 3.3 3 1 1 4 4 4 0 Predicted membrane protein (DUF2207) NB-ARC PF00931.20 001308246.1_49828001_1 - 0.044 12.7 0.6 8.1 5.2 0.1 2.5 2 0 0 2 2 2 0 NB-ARC domain NTPase_1 PF03266.13 001308246.1_49828001_1 - 0.045 13.5 1.2 0.86 9.4 0.1 2.8 3 0 0 3 3 2 0 NTPase DNA_pol3_beta PF00712.17 001308246.1_49828001_1 - 0.045 13.7 0.0 2.2 8.3 0.0 2.8 2 0 0 2 2 2 0 DNA polymerase III beta subunit, N-terminal domain PduV-EutP PF10662.7 001308246.1_49828001_1 - 0.053 13.1 1.3 24 4.5 0.0 3.6 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.4 001308246.1_49828001_1 - 0.082 13.3 0.1 19 5.6 0.0 3.1 3 0 0 3 3 2 0 AAA domain MMR_HSR1 PF01926.21 001308246.1_49828001_1 - 0.092 12.7 0.0 15 5.5 0.0 2.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase NEMP PF10225.7 001308246.1_49828001_1 - 0.85 9.2 4.7 0.48 10.0 0.6 2.6 2 0 0 2 2 2 0 NEMP family PMP22_Claudin PF00822.18 001308246.1_49828001_1 - 2.5 7.8 7.3 0.15 11.8 0.2 2.5 3 0 0 3 3 2 0 PMP-22/EMP/MP20/Claudin family Mog1 PF04603.10 001243370.1_49822001_2 - 4.2e-39 133.9 0.0 5.3e-39 133.6 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein UPF0697 PF15117.4 001190223.1_49824001_3 - 8.4e-57 189.2 0.4 1.2e-56 188.7 0.4 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0697 CENP-B_dimeris PF09026.8 001308826.1_49822001_3 - 0.038 14.3 11.8 0.057 13.7 11.8 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.4 001308826.1_49822001_3 - 0.075 12.6 0.6 0.11 12.0 0.6 1.2 1 0 0 1 1 1 0 FAM176 family PBP1_TM PF14812.4 001308826.1_49822001_3 - 0.082 13.2 7.5 0.14 12.5 7.5 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Phage_TTP_12 PF16461.3 001308826.1_49822001_3 - 0.14 11.9 0.2 0.19 11.4 0.2 1.2 1 0 0 1 1 1 0 Lambda phage tail tube protein, TTP Sporozoite_P67 PF05642.9 001308826.1_49822001_3 - 0.14 10.1 0.4 0.14 10.1 0.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Toxin_1 PF00087.19 001308826.1_49822001_3 - 0.48 10.6 15.4 0.78 9.9 15.4 1.4 1 0 0 1 1 1 0 Snake toxin DNA_pol_phi PF04931.11 001308826.1_49822001_3 - 0.53 8.2 6.6 0.73 7.7 6.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.10 001308826.1_49822001_3 - 0.61 8.1 2.9 0.72 7.9 2.9 1.0 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.7 001308826.1_49822001_3 - 0.76 8.7 10.6 1 8.3 10.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) EF-hand_1 PF00036.30 001006592.1_49822001_3 - 3.8e-09 35.3 3.2 1.9e-05 23.8 0.9 4.4 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.4 001006592.1_49822001_3 - 7e-08 31.7 2.0 2.5e-05 23.7 0.4 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 001006592.1_49822001_3 - 1e-07 32.2 0.1 0.00071 19.9 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 001006592.1_49822001_3 - 3.7e-05 23.3 2.2 0.0046 16.6 0.4 3.5 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.4 001006592.1_49822001_3 - 0.00031 20.0 1.1 0.00031 20.0 1.1 2.2 2 0 0 2 2 2 1 EF hand SNARE PF05739.17 001243381.1_49824001_3 - 4.4e-16 58.5 0.6 8.9e-16 57.5 0.6 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin-5_N PF11416.6 001243381.1_49824001_3 - 1.7e-12 46.1 1.4 4.2e-12 44.8 1.4 1.8 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.23 001243381.1_49824001_3 - 0.00052 19.6 15.4 0.0092 15.5 1.1 2.7 2 1 1 3 3 3 2 Syntaxin Cep3 PF16846.3 001243381.1_49824001_3 - 0.025 12.9 1.7 0.049 12.0 1.7 1.4 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit B SKA1 PF07160.10 001243381.1_49824001_3 - 0.11 12.2 9.7 0.65 9.6 1.6 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF16 PF01519.14 001243381.1_49824001_3 - 0.12 12.8 9.5 0.38 11.1 2.4 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF5063 PF16702.3 001243381.1_49824001_3 - 0.26 11.5 2.2 0.47 10.7 0.4 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF5063) DUF1664 PF07889.10 001243381.1_49824001_3 - 0.98 9.3 10.0 0.8 9.6 1.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Noelin-1 PF12308.6 001243381.1_49824001_3 - 1.9 8.4 5.0 6.2 6.7 0.2 2.7 2 0 0 2 2 2 0 Neurogenesis glycoprotein Syntaxin-18_N PF10496.7 001243381.1_49824001_3 - 3.1 8.0 5.6 1.3 9.1 0.1 3.0 4 0 0 4 4 4 0 SNARE-complex protein Syntaxin-18 N-terminus Fib_alpha PF08702.8 001243381.1_49824001_3 - 3.2 7.8 13.4 0.7 9.9 1.6 2.7 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.7 001243381.1_49824001_3 - 4.3 7.6 9.9 2 8.7 2.3 3.0 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4795 PF16043.3 001243381.1_49824001_3 - 4.8 6.6 7.9 5.6 6.4 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Reo_sigmaC PF04582.10 001243381.1_49824001_3 - 5.2 6.2 8.2 9.9 5.3 1.3 2.2 2 0 0 2 2 2 0 Reovirus sigma C capsid protein COG5 PF10392.7 001243381.1_49824001_3 - 7 6.7 9.3 0.97 9.5 0.4 2.7 2 1 1 3 3 3 0 Golgi transport complex subunit 5 WD40 PF00400.30 001243395.1_49823001_1 - 4.2e-11 43.1 0.2 0.17 12.7 0.0 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001243395.1_49823001_1 - 0.00053 20.1 0.0 0.014 15.5 0.0 2.8 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain BolA PF01722.16 001243396.1_49822001_1 - 7e-28 96.6 0.0 9.6e-28 96.2 0.0 1.2 1 0 0 1 1 1 1 BolA-like protein DUF814 PF05670.11 001243572.1_49825001_3 - 4.1e-27 94.0 0.2 9.2e-27 92.8 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF814) Phage_Mu_Gam PF07352.10 001243572.1_49825001_3 - 0.19 11.5 9.3 0.89 9.3 8.8 2.1 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein DDRGK PF09756.7 001243572.1_49825001_3 - 1.3 8.4 17.0 2.1 7.8 17.0 1.2 1 0 0 1 1 1 0 DDRGK domain PVL_ORF50 PF07768.9 001243572.1_49825001_3 - 4.2 7.6 12.0 7.5 6.8 12.0 1.3 1 0 0 1 1 1 0 PVL ORF-50-like family FHA PF00498.24 001167591.1_49824001_1 - 2.2e-11 43.8 0.0 4.4e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 FHA domain PHD PF00628.27 001167591.1_49824001_1 - 1.2e-06 28.1 12.7 1.2e-06 28.1 12.7 2.0 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.4 001167591.1_49824001_1 - 8.3 5.9 14.4 0.31 10.5 6.4 2.3 2 0 0 2 2 2 0 PHD-finger FLYWCH_N PF15423.4 001243398.1_49822001_1 - 9.4e-46 154.2 4.3 1.3e-45 153.8 4.3 1.2 1 0 0 1 1 1 1 FLYWCH-type zinc finger-containing protein Synaptonemal_3 PF15191.4 001206362.1_49821001_1 - 4.5e-38 128.8 4.4 5.1e-38 128.6 4.4 1.0 1 0 0 1 1 1 1 Synaptonemal complex central element protein 3 FlgN PF05130.10 001206362.1_49821001_1 - 0.021 15.2 1.5 0.025 15.0 1.5 1.1 1 0 0 1 1 1 0 FlgN protein Pox_polyA_pol_C PF12629.5 001206362.1_49821001_1 - 0.03 14.0 0.5 0.034 13.8 0.5 1.1 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase C-terminal domain Acetate_kinase PF00871.15 001206362.1_49821001_1 - 0.037 12.6 0.0 0.047 12.2 0.0 1.0 1 0 0 1 1 1 0 Acetokinase family DUF2935 PF11155.6 001206362.1_49821001_1 - 0.076 13.2 0.3 0.088 13.0 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) DUF342 PF03961.11 001206362.1_49821001_1 - 0.55 8.6 1.7 0.68 8.3 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DSBA PF01323.18 001315574.1_49824001_2 - 2.6e-55 187.1 0.0 3.3e-55 186.7 0.0 1.1 1 0 0 1 1 1 1 DSBA-like thioredoxin domain TPR_1 PF00515.26 001315572.1_49824001_2 - 1.7e-20 71.8 27.8 2.1e-05 24.0 0.1 8.9 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_2 PF07719.15 001315572.1_49824001_2 - 4.9e-20 69.9 30.1 6e-05 22.7 0.1 9.0 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_14 PF13428.4 001315572.1_49824001_2 - 3.8e-19 67.6 1.9 0.0039 17.8 0.1 7.1 7 1 0 7 7 6 4 Tetratricopeptide repeat TPR_12 PF13424.4 001315572.1_49824001_2 - 6.6e-19 67.9 13.4 5.3e-06 26.5 0.1 5.9 4 1 2 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.4 001315572.1_49824001_2 - 7.4e-17 60.0 22.2 0.00093 19.1 0.1 8.5 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.4 001315572.1_49824001_2 - 7.9e-16 58.2 14.2 0.0018 18.6 0.1 6.7 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_11 PF13414.4 001315572.1_49824001_2 - 1.3e-13 50.2 24.8 0.028 14.0 0.0 9.3 8 2 2 10 10 10 5 TPR repeat TPR_7 PF13176.4 001315572.1_49824001_2 - 6.4e-12 44.5 15.1 0.029 14.3 0.0 6.4 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_16 PF13432.4 001315572.1_49824001_2 - 8.6e-12 45.4 3.7 0.025 15.2 0.1 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.4 001315572.1_49824001_2 - 8.9e-12 44.4 17.3 0.58 10.5 0.0 9.4 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_15 PF13429.4 001315572.1_49824001_2 - 1.1e-11 44.4 10.3 6e-05 22.3 0.1 5.0 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_10 PF13374.4 001315572.1_49824001_2 - 2.3e-08 33.5 14.6 0.0015 18.2 0.4 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.4 001315572.1_49824001_2 - 2.4e-05 24.5 13.7 1.3 9.7 0.2 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.4 001315572.1_49824001_2 - 0.00041 20.3 2.0 8.3 6.5 0.0 4.7 5 1 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.5 001315572.1_49824001_2 - 0.00055 20.0 17.7 2 8.6 0.4 5.7 4 2 2 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 DUF4919 PF16266.3 001315572.1_49824001_2 - 0.0029 17.4 0.5 0.0029 17.4 0.5 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4919) NARP1 PF12569.6 001315572.1_49824001_2 - 0.0052 15.6 13.2 0.13 11.0 0.1 4.4 3 2 2 5 5 5 2 NMDA receptor-regulated protein 1 PUL PF08324.9 001315572.1_49824001_2 - 0.015 14.5 0.1 0.057 12.6 0.0 1.9 2 0 0 2 2 2 0 PUL domain PPR PF01535.18 001315572.1_49824001_2 - 0.022 14.9 0.3 4 7.8 0.0 3.1 2 0 0 2 2 2 0 PPR repeat TPR_20 PF14561.4 001315572.1_49824001_2 - 0.045 14.0 7.4 25 5.1 0.0 5.5 4 2 1 5 5 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 001315572.1_49824001_2 - 0.071 13.1 4.0 1 9.3 0.0 4.0 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat DUF4810 PF16068.3 001315572.1_49824001_2 - 0.1 13.0 0.2 0.1 13.0 0.2 4.3 4 1 1 5 5 5 0 Domain of unknown function (DUF4810) Mad3_BUB1_I PF08311.10 001315572.1_49824001_2 - 0.2 11.5 4.2 2.3 8.1 0.0 3.6 3 0 0 3 3 3 0 Mad3/BUB1 homology region 1 Josephin PF02099.15 001243416.1_49822001_2 - 5.1e-27 94.8 0.0 1.3e-25 90.3 0.0 2.0 1 1 0 1 1 1 1 Josephin MSC PF09402.8 001315597.1_49829001_2 - 2.5e-20 73.1 0.1 3.7e-20 72.6 0.1 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain LEM PF03020.13 001315597.1_49829001_2 - 1e-17 63.2 0.2 2e-17 62.3 0.2 1.5 1 0 0 1 1 1 1 LEM domain RBM39linker PF15519.4 001315597.1_49829001_2 - 0.011 16.6 1.1 0.036 15.0 0.0 2.3 2 0 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein Cpn60_TCP1 PF00118.22 001243427.1_49824001_3 - 4.9e-157 523.3 11.9 5.6e-157 523.2 11.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Tubulin PF00091.23 001243434.1_49824001_1 - 3.4e-69 232.9 0.0 5.2e-69 232.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001243434.1_49824001_1 - 4e-43 146.5 0.1 6e-43 145.9 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 001243434.1_49824001_1 - 9.4e-06 25.8 0.0 2.1e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.4 001243434.1_49824001_1 - 0.026 14.1 0.0 0.047 13.2 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.4 001243434.1_49824001_1 - 0.026 13.6 0.0 0.049 12.7 0.0 1.4 1 0 0 1 1 1 0 Tubulin like DUF1077 PF06417.10 001243441.1_49823001_1 - 1.8e-45 153.6 3.5 2.9e-45 152.9 3.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) LRR_8 PF13855.4 001315660.1_49823001_1 - 1.5e-19 69.4 4.4 1.1e-05 25.0 0.3 4.7 3 2 2 5 5 5 4 Leucine rich repeat LRR_5 PF13306.4 001315660.1_49823001_1 - 8.4e-16 58.0 3.1 1.9e-08 34.2 0.8 2.3 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001315660.1_49823001_1 - 0.0016 18.6 4.8 0.55 10.6 0.5 4.4 3 2 2 5 5 5 2 Leucine Rich repeats (2 copies) Methyltransf_PK PF05891.10 001243457.1_49824001_1 - 6.6e-93 310.1 0.0 8e-93 309.8 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.4 001243457.1_49824001_1 - 7e-12 45.8 0.0 1.1e-11 45.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001243457.1_49824001_1 - 2.6e-10 40.7 0.0 4.1e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001243457.1_49824001_1 - 4.2e-08 33.7 0.0 6.8e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.16 001243457.1_49824001_1 - 0.00015 20.9 0.0 0.00022 20.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Ubie_methyltran PF01209.16 001243457.1_49824001_1 - 0.00029 20.1 0.0 0.00043 19.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.4 001243457.1_49824001_1 - 0.0025 17.5 0.0 0.0039 16.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001243457.1_49824001_1 - 0.023 14.5 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_29 PF03141.14 001243457.1_49824001_1 - 0.037 12.5 0.0 0.056 11.8 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Ribosomal_L26 PF16906.3 001243458.1_49822001_2 - 6.1e-44 148.3 5.7 8.7e-44 147.8 5.7 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.27 001243458.1_49822001_2 - 1e-07 31.5 5.7 2.9e-07 30.1 5.7 1.9 1 1 0 1 1 1 1 KOW motif Pkinase PF00069.23 001315672.1_49824001_1 - 2.1e-63 214.1 0.0 2.6e-63 213.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001315672.1_49824001_1 - 1.1e-47 162.4 0.0 1.6e-47 161.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.6 001315672.1_49824001_1 - 6.2e-14 51.5 0.0 1.3e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C terminal Kinase-like PF14531.4 001315672.1_49824001_1 - 0.00043 19.6 0.0 0.0007 18.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like TBCC PF07986.10 001243469.1_49825001_1 - 5.6e-38 129.2 0.2 1e-37 128.4 0.2 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.9 001243469.1_49825001_1 - 0.0017 17.9 1.5 0.0033 16.9 1.5 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal Sulfotransfer_3 PF13469.4 001243490.1_49824001_2 - 1.2e-57 195.7 0.0 1.8e-57 195.1 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.25 001243490.1_49824001_2 - 9e-07 28.5 0.0 5.1e-06 26.0 0.0 2.1 1 1 0 1 1 1 1 Sulfotransferase domain DUF727 PF05303.10 001243496.1_49825001_2 - 1.5e-31 108.5 0.0 2.2e-31 107.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF727) Claudin_2 PF13903.4 001243498.1_49825001_3 - 7.2e-22 78.0 1.8 7.2e-22 78.0 1.8 1.6 2 0 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.18 001243498.1_49825001_3 - 5.3e-10 39.3 7.0 1.1e-07 31.8 7.0 2.8 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Got1 PF04178.10 001243500.1_49827001_1 - 4.6e-16 59.1 16.8 4.6e-16 59.1 16.8 2.4 3 0 0 3 3 3 1 Got1/Sft2-like family TOM6p PF15184.4 001243500.1_49827001_3 - 0.14 11.8 0.1 0.29 10.8 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial import receptor subunit TOM6 homolog Guanylate_cyc_2 PF09778.7 001243502.1_49822001_3 - 1e-90 302.5 0.4 1.2e-90 302.4 0.4 1.0 1 0 0 1 1 1 1 Guanylylate cyclase Peptidase_C39_2 PF13529.4 001243502.1_49822001_3 - 2.9e-08 34.2 0.0 1.4e-07 32.0 0.0 2.1 1 1 0 1 1 1 1 Peptidase_C39 like family Peptidase_C70 PF12385.6 001243502.1_49822001_3 - 8.8e-07 28.9 0.0 0.053 13.4 0.0 2.6 2 1 0 2 2 2 2 Papain-like cysteine protease AvrRpt2 DUF3335 PF11814.6 001243502.1_49822001_3 - 9.1e-06 25.1 0.1 0.0069 15.7 0.0 2.2 2 0 0 2 2 2 2 Peptidase_C39 like family Peptidase_C39 PF03412.13 001243502.1_49822001_3 - 0.00046 19.9 0.0 0.028 14.1 0.0 2.4 2 0 0 2 2 2 1 Peptidase C39 family zf-C3HC4_3 PF13920.4 001243502.1_49822001_3 - 1.6 8.5 8.2 4.2 7.2 8.2 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) EF1_GNE PF00736.17 001243524.1_49823001_2 - 2.4e-37 126.8 0.5 3.9e-37 126.2 0.5 1.3 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.7 001243524.1_49823001_2 - 4.8e-13 49.2 9.1 4.8e-13 49.2 9.1 2.3 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.4 001243524.1_49823001_2 - 0.048 13.7 0.2 0.57 10.3 0.0 2.2 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 001243524.1_49823001_2 - 0.067 12.9 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Med21 PF11221.6 001243530.1_49822001_2 - 1.6e-26 93.1 2.2 3.6e-26 92.0 2.2 1.5 1 1 0 1 1 1 1 Subunit 21 of Mediator complex TelA PF05816.9 001243530.1_49822001_2 - 0.043 12.8 0.2 0.067 12.1 0.2 1.2 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) F420_ligase PF01996.14 001243530.1_49822001_2 - 0.13 11.5 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 F420-0:Gamma-glutamyl ligase Band_7 PF01145.23 001243556.1_49823001_3 - 2.5e-22 79.6 2.6 3.8e-22 79.0 2.6 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Med2 PF11214.6 001243556.1_49823001_3 - 0.0011 18.9 1.5 0.0021 18.1 1.5 1.4 1 0 0 1 1 1 1 Mediator complex subunit 2 Pkinase PF00069.23 001243563.1_49824001_1 - 9.4e-73 244.7 0.0 1.3e-72 244.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001243563.1_49824001_1 - 1.5e-33 116.1 0.0 1.9e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.20 001243563.1_49824001_1 - 0.00091 18.7 0.1 0.0016 17.9 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.12 001243563.1_49824001_1 - 0.00094 18.5 0.0 0.0019 17.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Glycos_trans_3N PF02885.15 001243563.1_49824001_1 - 0.16 11.7 0.5 0.75 9.5 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain Med28 PF11594.6 001243569.1_49826001_1 - 1.7e-22 79.8 2.7 6.6e-17 61.7 1.0 2.3 1 1 1 2 2 2 2 Mediator complex subunit 28 I-set PF07679.14 001033014.1_49824001_3 - 2.4e-31 107.5 0.0 1.1e-15 57.3 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain fn3 PF00041.19 001033014.1_49824001_3 - 2e-24 85.6 0.0 7.6e-11 42.1 0.0 2.6 3 0 0 3 3 3 2 Fibronectin type III domain Ig_3 PF13927.4 001033014.1_49824001_3 - 9.5e-23 80.5 0.1 4.5e-12 46.3 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001033014.1_49824001_3 - 6.9e-12 45.4 0.0 6.6e-06 26.3 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001033014.1_49824001_3 - 7.2e-09 35.6 0.0 1.1e-06 28.6 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.15 001033014.1_49824001_3 - 7.3e-08 32.4 0.2 0.012 15.6 0.0 3.2 2 2 0 2 2 2 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 001033014.1_49824001_3 - 0.013 15.5 0.1 6.7 6.7 0.0 2.5 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain SCAN PF02023.15 001243578.1_49823001_3 - 2.9e-25 87.8 0.6 4.4e-25 87.2 0.6 1.2 1 0 0 1 1 1 1 SCAN domain Dsl1_C PF11989.6 001243578.1_49823001_3 - 0.1 11.9 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 C terminal Glyco_transf_29 PF00777.16 001037322.1_49829001_2 - 3.3e-75 252.8 0.0 4.2e-75 252.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) STAT_bind PF02864.13 001315784.1_49825001_1 - 1.7e-73 247.4 0.8 1.7e-73 247.4 0.8 2.1 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 001315784.1_49825001_1 - 9.7e-54 181.8 13.1 9.7e-54 181.8 13.1 1.8 2 0 0 2 2 2 1 STAT protein, all-alpha domain STAT_int PF02865.15 001315784.1_49825001_1 - 3.9e-38 130.5 4.7 3.9e-38 130.5 4.7 3.4 3 1 0 4 4 4 1 STAT protein, protein interaction domain SH2 PF00017.22 001315784.1_49825001_1 - 7.2e-12 45.1 0.0 4.8e-11 42.4 0.0 2.5 2 0 0 2 2 2 1 SH2 domain STAT1_TAZ2bind PF12162.6 001315784.1_49825001_1 - 0.11 11.9 0.5 0.26 10.8 0.5 1.6 1 0 0 1 1 1 0 STAT1 TAZ2 binding domain NPV_P10 PF05531.10 001315784.1_49825001_1 - 0.2 12.0 5.0 0.35 11.2 2.3 2.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein NDK PF00334.17 045137.1_49822120_2 - 1.5e-54 183.5 0.0 1.9e-54 183.2 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase ODC_AZ PF02100.15 125342.1_49823120_2 - 4.2e-20 71.7 0.0 7.4e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme CD36 PF01130.19 001285580.1_09024001_1 - 6.9e-145 483.0 1.0 8.1e-145 482.8 1.0 1.0 1 0 0 1 1 1 1 CD36 family Cyt-b5 PF00173.26 001287234.1_09021001_1 - 1.3e-22 79.6 0.0 1.7e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Pox_EPC_I2-L1 PF12575.6 001287234.1_09021001_1 - 0.15 12.1 0.1 0.36 10.9 0.1 1.6 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 Telethonin PF09470.8 001285752.1_09022001_2 - 6.3e-74 247.3 2.0 7.3e-74 247.0 2.0 1.0 1 0 0 1 1 1 1 Telethonin protein ANP PF00212.16 001287236.1_09022001_2 - 3e-11 43.1 3.3 6.1e-11 42.2 3.3 1.6 1 0 0 1 1 1 1 Atrial natriuretic peptide EF-hand_1 PF00036.30 001285754.1_09022001_1 - 1.4e-09 36.7 2.5 1.6e-05 24.0 0.9 4.4 5 0 0 5 5 5 2 EF hand EF-hand_7 PF13499.4 001285754.1_09022001_1 - 1.4e-08 34.9 0.1 0.0006 20.1 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001285754.1_09022001_1 - 4.5e-08 32.3 1.8 2.1e-05 23.9 0.4 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.4 001285754.1_09022001_1 - 8.7e-06 25.3 2.0 0.004 16.8 0.4 3.9 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.4 001285754.1_09022001_1 - 0.00027 20.2 1.1 0.00027 20.2 1.1 2.2 2 0 0 2 2 2 1 EF hand Lipase PF00151.17 001285607.1_09023001_1 - 4.7e-132 440.2 0.0 6.8e-132 439.7 0.0 1.2 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 001285607.1_09023001_1 - 2.3e-23 82.8 0.5 4.4e-23 81.9 0.5 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.5 001285607.1_09023001_1 - 9e-06 26.3 0.4 1.4e-05 25.7 0.4 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 001285607.1_09023001_1 - 0.00047 19.7 0.1 0.00075 19.1 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Calsarcin PF05556.9 001289949.1_09022001_1 - 1.9e-35 122.4 0.0 3.8e-35 121.4 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) Somatostatin PF03002.13 001287555.1_09021001_1 - 2.7e-12 46.3 8.4 4e-12 45.7 8.4 1.3 1 0 0 1 1 1 1 Somatostatin/Cortistatin family LRR_8 PF13855.4 001285613.1_09022001_1 - 5.8e-19 67.5 9.1 1.2e-09 37.7 0.1 4.1 3 1 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 001285613.1_09022001_1 - 9.8e-10 38.4 15.2 3.6e-05 23.9 2.0 4.5 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001285613.1_09022001_1 - 8.3e-06 25.4 12.2 1.2 9.7 0.0 5.8 5 1 0 5 5 5 2 Leucine Rich Repeat LRR_5 PF13306.4 001285613.1_09022001_1 - 0.00042 20.1 1.5 0.29 11.0 0.0 2.4 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_6 PF13516.4 001285613.1_09022001_1 - 0.0046 16.8 1.5 6.8 6.9 0.0 4.2 4 0 0 4 4 4 1 Leucine Rich repeat LRR_9 PF14580.4 001285613.1_09022001_1 - 0.036 13.4 2.1 0.17 11.2 0.1 2.1 1 1 2 3 3 3 0 Leucine-rich repeat DUF1409 PF07197.10 001285613.1_09022001_1 - 0.095 12.5 0.1 1.7 8.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1409) DUF2053 PF09767.7 001314309.1_09022001_1 - 5.6e-67 224.7 5.6 5.6e-67 224.7 5.6 1.7 2 0 0 2 2 2 1 Predicted membrane protein (DUF2053) Cathelicidins PF00666.15 001285545.1_09022001_1 - 8e-48 160.8 0.5 1e-47 160.4 0.5 1.1 1 0 0 1 1 1 1 Cathelicidin Spp-24 PF07448.9 001285545.1_09022001_1 - 1.3e-05 25.1 0.2 2e-05 24.6 0.2 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Trypan_PARP PF05887.9 001285545.1_09022001_1 - 0.28 11.1 2.6 0.6 10.0 2.6 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Cathelicidins PF00666.15 001285546.1_09022001_1 - 1.5e-48 163.1 0.2 1.9e-48 162.8 0.2 1.1 1 0 0 1 1 1 1 Cathelicidin Spp-24 PF07448.9 001285546.1_09022001_1 - 0.00015 21.8 0.2 0.00022 21.2 0.2 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Cystatin PF00031.19 001285546.1_09022001_1 - 0.13 12.4 0.5 1.8 8.8 0.1 2.1 2 0 0 2 2 2 0 Cystatin domain Gal-bind_lectin PF00337.20 001285625.1_09021001_2 - 1e-21 76.8 0.0 1.2e-21 76.5 0.0 1.1 1 0 0 1 1 1 1 Galactoside-binding lectin MHC_II_beta PF00969.17 001314166.1_09022001_1 - 3.3e-32 110.3 0.9 7.1e-32 109.2 0.6 1.7 2 0 0 2 2 2 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001314166.1_09022001_1 - 1e-24 86.7 0.1 2.5e-24 85.4 0.1 1.7 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001314166.1_09022001_1 - 0.00047 20.6 0.1 0.0013 19.2 0.0 1.8 1 1 1 2 2 2 1 Immunoglobulin domain DUF202 PF02656.13 001314166.1_09022001_1 - 0.041 14.2 0.0 0.072 13.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) ig PF00047.23 001314166.1_09022001_1 - 0.084 12.9 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin domain SAA PF00277.16 001285637.1_09022001_3 - 1.2e-43 147.6 2.1 1.8e-43 147.1 2.1 1.3 1 0 0 1 1 1 1 Serum amyloid A protein Peptidase_M2 PF01401.16 001290107.1_09025001_1 - 2.2e-236 785.9 10.0 2.6e-236 785.6 10.0 1.0 1 0 0 1 1 1 1 Angiotensin-converting enzyme Collectrin PF16959.3 001290107.1_09025001_1 - 2.4e-74 248.1 0.0 4.8e-74 247.1 0.0 1.5 1 0 0 1 1 1 1 Renal amino acid transporter Glycophorin_A PF01102.16 001290107.1_09025001_1 - 0.0056 16.8 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 Glycophorin A HAUS2 PF15003.4 001290107.1_09025001_1 - 0.075 12.6 1.8 0.22 11.1 0.9 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 2 EphA2_TM PF14575.4 001290107.1_09025001_1 - 0.08 13.6 0.0 0.23 12.2 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4440 PF14534.4 001290107.1_09025001_1 - 0.084 13.1 0.1 22 5.4 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4440) GHBP PF12772.5 001285648.1_09025001_3 - 1.2e-132 441.8 3.9 1.6e-132 441.5 3.9 1.1 1 0 0 1 1 1 1 Growth hormone receptor binding EpoR_lig-bind PF09067.8 001285648.1_09025001_3 - 5.4e-12 45.7 2.0 1.7e-11 44.1 2.0 1.9 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 001285648.1_09025001_3 - 1.1e-05 25.6 0.1 2.3e-05 24.5 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III domain IL6Ra-bind PF09240.8 001285648.1_09025001_3 - 0.031 14.6 1.1 0.07 13.4 1.1 1.5 1 0 0 1 1 1 0 Interleukin-6 receptor alpha chain, binding Glyco_hydro_18 PF00704.26 001285584.1_09024001_1 - 7.9e-79 265.5 0.0 9.5e-79 265.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF552 PF04472.10 001285584.1_09024001_1 - 0.11 12.7 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF552) Osteopontin PF00865.16 001285667.1_09022001_1 - 2.4e-93 312.7 54.7 7e-76 255.4 30.3 2.0 1 1 1 2 2 2 2 Osteopontin Guanylate_cyc PF00211.18 001285674.1_09027001_1 - 3.7e-68 228.6 0.0 8e-68 227.5 0.0 1.5 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain ANF_receptor PF01094.26 001285674.1_09027001_1 - 5.5e-45 153.9 0.0 9e-45 153.2 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Pkinase_Tyr PF07714.15 001285674.1_09027001_1 - 2.1e-38 132.0 0.0 3.1e-38 131.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001285674.1_09027001_1 - 1.6e-32 112.8 0.0 2.9e-32 112.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Peripla_BP_6 PF13458.4 001285674.1_09027001_1 - 6.2e-05 22.7 0.0 0.00013 21.6 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein HNOBA PF07701.12 001285674.1_09027001_1 - 0.00018 20.9 0.7 0.0003 20.2 0.7 1.3 1 0 0 1 1 1 1 Heme NO binding associated MlaC PF05494.10 001285674.1_09027001_1 - 0.2 11.3 0.1 0.39 10.4 0.1 1.4 1 0 0 1 1 1 0 MlaC protein Arginase PF00491.19 001285705.1_09023001_2 - 3.4e-76 256.3 0.0 4.2e-76 256.0 0.0 1.0 1 0 0 1 1 1 1 Arginase family TGFb_propeptide PF00688.16 001287564.1_09023001_3 - 1.8e-50 171.8 0.5 2.7e-50 171.3 0.5 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001287564.1_09023001_3 - 1.1e-34 119.3 0.7 2e-34 118.5 0.7 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain Proteasome PF00227.24 001285698.1_09022001_2 - 3e-54 183.3 0.2 3.8e-54 182.9 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 001285698.1_09022001_2 - 4.7e-15 54.8 0.1 8e-15 54.0 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature p450 PF00067.20 001286090.1_09024001_1 - 6.3e-130 433.9 0.0 7.7e-130 433.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Replic_Relax PF13814.4 001286090.1_09024001_1 - 0.056 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Replication-relaxation YjcB PF15940.3 001286090.1_09024001_2 - 0.024 14.7 0.1 0.053 13.6 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function Perilipin PF03036.14 001285596.1_09023001_1 - 9.3e-164 545.0 11.8 1.1e-163 544.8 11.8 1.0 1 0 0 1 1 1 1 Perilipin family DUF4618 PF15397.4 001285596.1_09023001_1 - 0.048 13.0 3.2 0.071 12.4 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) DUF1664 PF07889.10 001285596.1_09023001_1 - 0.25 11.2 4.5 11 5.9 0.1 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) V-SNARE_C PF12352.6 001285596.1_09023001_1 - 0.34 11.1 3.5 0.38 11.0 0.9 2.3 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Apolipoprotein PF01442.16 001285596.1_09023001_1 - 0.34 10.7 4.7 1.6 8.5 0.1 3.0 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain HSP9_HSP12 PF04119.10 001285596.1_09023001_1 - 0.36 11.1 4.5 4.9 7.5 0.0 3.6 3 1 0 3 3 3 0 Heat shock protein 9/12 Snapin_Pallidin PF14712.4 001285596.1_09023001_1 - 1 9.7 6.1 1.5 9.1 0.7 3.3 3 1 0 3 3 3 0 Snapin/Pallidin Laminin_II PF06009.10 001285596.1_09023001_1 - 1.2 9.0 6.1 3.6 7.5 0.1 3.4 3 1 1 4 4 4 0 Laminin Domain II Nup54 PF13874.4 001285596.1_09023001_1 - 4.7 7.2 6.7 47 3.9 6.3 2.6 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Baculo_PEP_C PF04513.10 001285596.1_09023001_1 - 7.2 6.5 10.2 2.6 8.0 0.4 3.0 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tyrosinase PF00264.18 001287562.1_09025001_3 - 4.3e-43 148.1 0.3 5.6e-43 147.7 0.3 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase Laminin_EGF PF00053.22 001287562.1_09025001_3 - 0.021 14.8 2.1 0.021 14.8 2.1 3.1 4 0 0 4 4 4 0 Laminin EGF domain C1q PF00386.19 001287573.1_09022001_1 - 2e-40 137.8 1.6 2.4e-40 137.5 1.6 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 001287573.1_09022001_1 - 2.2e-10 40.0 31.8 4.7e-08 32.5 31.8 2.5 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) Crisp PF08562.8 001285745.1_09023001_3 - 1.1e-20 73.8 21.4 2.5e-20 72.6 21.4 1.7 1 0 0 1 1 1 1 Crisp CAP PF00188.24 001285745.1_09023001_3 - 1.2e-19 71.3 3.0 1.9e-19 70.6 3.0 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family 40S_SA_C PF16122.3 001285749.1_09022001_1 - 4.3e-28 98.4 20.8 7.3e-28 97.7 20.8 1.4 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Ribosomal_S2 PF00318.18 001285749.1_09022001_1 - 1.1e-25 90.0 0.0 1.3e-12 47.3 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 Ald_Xan_dh_C2 PF02738.16 001285624.1_09029001_1 - 9.6e-211 700.8 0.0 1.3e-210 700.4 0.0 1.2 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001285624.1_09029001_1 - 1.8e-46 157.8 0.0 3.6e-46 156.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 001285624.1_09029001_1 - 1.4e-37 128.2 0.0 2.8e-37 127.3 0.0 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 001285624.1_09029001_1 - 2.1e-31 107.6 0.1 5.1e-31 106.3 0.1 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 001285624.1_09029001_1 - 1.3e-27 95.9 0.0 5e-27 93.9 0.0 2.0 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001285624.1_09029001_1 - 9.8e-10 38.1 2.2 3.7e-09 36.3 0.2 2.6 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Calsarcin PF05556.9 001287568.1_09022001_3 - 3.1e-89 298.5 1.4 3.6e-89 298.3 1.4 1.0 1 0 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) CCER1 PF15482.4 001287568.1_09022001_3 - 0.076 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 KH_1 PF00013.27 001285649.1_09024001_2 - 2.7e-43 145.5 14.3 4.9e-20 71.0 1.9 3.2 3 0 0 3 3 3 3 KH domain ROKNT PF08067.9 001285649.1_09024001_2 - 1.4e-26 92.3 9.8 2.4e-26 91.5 9.8 1.4 1 0 0 1 1 1 1 ROKNT (NUC014) domain KH_2 PF07650.15 001285649.1_09024001_2 - 6.9e-14 51.3 7.3 0.00074 19.2 0.5 3.8 3 1 0 4 4 4 3 KH domain KH_4 PF13083.4 001285649.1_09024001_2 - 6.6e-09 35.4 4.3 5.8e-06 26.0 0.0 3.3 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 001285649.1_09024001_2 - 0.00028 20.8 6.3 0.29 11.1 0.1 3.5 3 1 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.3 001285649.1_09024001_2 - 0.021 14.7 0.0 1.4 8.9 0.0 2.3 2 0 0 2 2 2 0 KH-like RNA-binding domain DJ-1_PfpI PF01965.22 001285649.1_09024001_2 - 0.029 14.0 0.0 0.065 12.9 0.0 1.5 2 0 0 2 2 2 0 DJ-1/PfpI family Serpin PF00079.18 001314301.1_09023001_2 - 1.2e-94 317.5 14.8 1.8e-94 317.0 14.8 1.2 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) N1221 PF07923.11 001314301.1_09023001_2 - 0.0056 15.8 2.1 0.011 14.8 2.0 1.6 1 1 0 1 1 1 1 N1221-like protein FAD-SLDH PF12318.6 001314301.1_09023001_2 - 1 9.3 3.8 0.63 10.0 0.2 2.2 1 1 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase HlyIII PF03006.18 001285730.1_09023001_1 - 4.8e-73 245.4 19.8 5.8e-73 245.2 19.8 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF4405 PF14358.4 001285730.1_09023001_1 - 0.013 15.9 3.3 0.013 15.9 3.3 3.8 3 1 1 4 4 4 0 Domain of unknown function (DUF4405) DUF962 PF06127.9 001285730.1_09023001_1 - 0.026 14.5 1.4 0.026 14.5 1.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF962) DUF1049 PF06305.9 001285730.1_09023001_1 - 2.6 7.8 4.5 11 5.9 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) SapB_1 PF05184.13 001105262.1_39522001_1 - 3.7e-07 29.9 0.0 1e-06 28.5 0.0 1.8 1 0 0 1 1 1 1 Saposin-like type B, region 1 SapB_2 PF03489.15 001105262.1_39522001_1 - 8.6e-05 22.4 1.6 0.0016 18.4 0.2 2.7 3 0 0 3 3 3 1 Saposin-like type B, region 2 Filament PF00038.19 001114763.2_39524001_1 - 4.7e-101 338.3 19.2 6.2e-101 337.9 19.2 1.1 1 0 0 1 1 1 1 Intermediate filament protein ATG16 PF08614.9 001114763.2_39524001_1 - 0.0063 16.6 24.8 0.35 10.9 0.4 4.1 3 1 1 4 4 4 3 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.10 001114763.2_39524001_1 - 0.021 14.7 26.5 0.039 13.9 1.5 3.7 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein V_ATPase_I PF01496.17 001114763.2_39524001_1 - 1.9 6.1 8.0 0.24 9.1 3.0 1.8 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family SlyX PF04102.10 001114763.2_39524001_1 - 2.2 8.8 13.9 67 4.1 0.1 4.7 3 1 2 5 5 5 0 SlyX IncA PF04156.12 001114763.2_39524001_1 - 2.8 7.6 23.8 1.8e+02 1.6 0.0 3.8 2 1 1 3 3 2 0 IncA protein DUF4446 PF14584.4 001114763.2_39524001_1 - 2.9 7.7 8.4 5.2 6.9 0.0 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) DUF724 PF05266.12 001114763.2_39524001_1 - 3.5 7.3 10.2 1.5 8.5 3.2 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF724) FlxA PF14282.4 001114763.2_39524001_1 - 4.1 7.3 20.2 0.045 13.6 5.6 3.8 2 2 2 4 4 4 0 FlxA-like protein DUF4140 PF13600.4 001114763.2_39524001_1 - 7.5 6.9 13.4 67 3.9 0.4 4.3 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF4407 PF14362.4 001114763.2_39524001_1 - 8 5.6 18.3 1.3e+02 1.6 0.1 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF1241 PF06840.9 001280676.1_39523001_1 - 1.2e-62 209.9 3.4 1.6e-62 209.4 3.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) CENP-L PF13092.4 001280676.1_39523001_1 - 0.038 14.1 0.2 0.097 12.7 0.2 1.7 2 0 0 2 2 2 0 Kinetochore complex Sim4 subunit Fta1 Focal_AT PF03623.11 001280676.1_39523001_1 - 0.052 13.4 0.1 0.1 12.4 0.1 1.5 1 0 0 1 1 1 0 Focal adhesion targeting region Med11 PF10280.7 001280676.1_39523001_1 - 0.1 12.9 0.5 0.23 11.8 0.4 1.7 1 1 0 1 1 1 0 Mediator complex protein Syntaxin_2 PF14523.4 001280676.1_39523001_1 - 0.31 11.3 4.7 0.73 10.1 4.7 1.6 1 1 0 1 1 1 0 Syntaxin-like protein APOBEC_N PF08210.9 001093784.1_39523001_1 - 3.2e-88 294.1 13.1 2.1e-48 164.5 6.1 2.0 2 0 0 2 2 2 2 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001093784.1_39523001_1 - 6.4e-64 211.7 4.5 2.6e-32 110.4 0.4 2.3 2 0 0 2 2 2 2 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001093784.1_39523001_1 - 4.9e-06 26.2 0.1 0.0054 16.5 0.0 2.2 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region Toxin-deaminase PF14424.4 001093784.1_39523001_1 - 0.0041 17.1 0.6 0.72 9.8 0.0 2.2 2 0 0 2 2 2 2 The BURPS668_1122 family of deaminases MafB19-deam PF14437.4 001093784.1_39523001_1 - 0.0086 15.7 0.1 0.18 11.4 0.0 2.2 2 0 0 2 2 2 1 MafB19-like deaminase DUF929 PF06053.9 001093784.1_39523001_1 - 0.017 14.3 0.0 0.031 13.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF929) XOO_2897-deam PF14440.4 001093784.1_39523001_1 - 0.044 13.8 0.6 4.6 7.3 0.0 2.8 3 0 0 3 3 3 0 Xanthomonas XOO_2897-like deaminase IL22 PF14565.4 001260478.1_39522001_2 - 1.1e-59 200.6 0.9 1.3e-59 200.3 0.9 1.1 1 0 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor IL10 PF00726.15 001260478.1_39522001_2 - 0.0003 20.2 0.5 0.00041 19.8 0.5 1.2 1 0 0 1 1 1 1 Interleukin 10 Resistin PF06954.9 001306111.1_39521001_1 - 2.9e-36 123.8 14.9 3.4e-36 123.5 14.9 1.0 1 0 0 1 1 1 1 Resistin CBM_1 PF00734.16 001306111.1_39521001_1 - 0.049 13.5 4.0 0.049 13.5 4.0 3.3 4 1 0 4 4 4 0 Fungal cellulose binding domain Peptidase_M28 PF04389.15 001166178.1_39523001_1 - 1.7e-46 158.3 0.0 2.2e-46 157.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 Reticulon PF02453.15 001145178.1_39522001_1 - 2.4e-47 160.6 6.8 3.2e-47 160.3 6.8 1.1 1 0 0 1 1 1 1 Reticulon DUF639 PF04842.10 001145178.1_39522001_1 - 0.01 15.1 1.8 0.016 14.5 1.8 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) DUF4736 PF15883.3 001145178.1_39522001_1 - 0.13 11.8 0.2 0.13 11.8 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4736) IL8 PF00048.18 001099629.1_39521001_2 - 2.7e-22 78.6 0.7 4.6e-22 77.8 0.7 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like PAS_3 PF08447.10 001287463.1_39525001_1 - 3.9e-15 55.8 0.0 5.9e-10 39.2 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 001287463.1_39525001_1 - 8.4e-07 29.0 0.0 1.2e-05 25.2 0.0 2.2 2 0 0 2 2 2 1 PAS domain HLH PF00010.24 001287463.1_39525001_1 - 0.00049 19.9 0.5 0.00097 18.9 0.5 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS PF00989.23 001287463.1_39525001_1 - 0.0037 17.1 0.0 0.91 9.4 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.8 001287463.1_39525001_1 - 0.15 12.2 0.0 11 6.1 0.0 2.5 2 0 0 2 2 2 0 PAS fold SP_C-Propep PF08999.8 001009729.1_39522001_1 - 2.8e-51 171.1 3.6 3.9e-51 170.6 3.6 1.2 1 0 0 1 1 1 1 Surfactant protein C, N terminal propeptide BRICHOS PF04089.12 001009729.1_39522001_1 - 1.3e-20 73.2 0.0 1.8e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 BRICHOS domain PTPS_related PF10131.7 001009729.1_39522001_1 - 0.027 12.7 0.1 0.035 12.3 0.1 1.0 1 0 0 1 1 1 0 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein DUF4330 PF14221.4 001009729.1_39522001_1 - 0.16 12.0 1.7 0.24 11.5 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4330) DUF945 PF06097.9 001009729.1_39522001_1 - 0.24 10.3 0.8 0.33 9.9 0.8 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) FA_desaturase PF00487.22 001112815.1_39526001_3 - 2.2e-15 57.1 14.8 2.2e-15 57.1 14.8 1.5 1 1 0 1 1 1 1 Fatty acid desaturase Fibrinogen_C PF00147.16 001202852.1_39523001_2 - 0.0012 18.5 0.3 0.002 17.8 0.3 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Glyco_transf_29 PF00777.16 001112818.1_39523001_2 - 3e-62 210.3 0.0 3.7e-62 210.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) E1_dh PF00676.18 001126344.1_39523001_1 - 1.2e-114 382.2 0.0 1.5e-114 381.9 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.19 001126344.1_39523001_1 - 0.00031 20.4 0.1 0.0013 18.4 0.1 2.0 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.4 001126344.1_39523001_1 - 0.002 17.3 0.0 0.0048 16.0 0.0 1.6 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Ig_2 PF13895.4 001139452.1_39523001_2 - 1.1e-27 96.1 0.1 4.1e-09 36.5 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 001139452.1_39523001_2 - 2.3e-18 66.4 0.2 1.7e-06 28.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 001139452.1_39523001_2 - 6.1e-12 45.4 2.0 0.00037 20.5 0.0 3.9 3 2 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001139452.1_39523001_2 - 7.9e-08 32.3 2.6 0.054 13.5 0.1 5.3 4 2 2 6 6 6 2 Immunoglobulin V-set domain Ig_4 PF16680.3 001139452.1_39523001_2 - 2.1e-05 24.6 0.0 3.5 7.9 0.0 3.4 3 0 0 3 3 3 3 T-cell surface glycoprotein CD3 delta chain I-set PF07679.14 001139452.1_39523001_2 - 0.0012 18.7 0.2 2.6 8.0 0.0 3.8 4 2 0 4 4 4 1 Immunoglobulin I-set domain Izumo-Ig PF16706.3 001139452.1_39523001_2 - 0.0041 17.0 0.0 1.6 8.7 0.0 3.2 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Arylesterase PF01731.18 001126348.1_39523001_1 - 2.6e-41 139.6 0.6 4.6e-41 138.8 0.6 1.4 1 0 0 1 1 1 1 Arylesterase SGL PF08450.10 001126348.1_39523001_1 - 9.1e-09 35.1 0.0 1.4e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Str_synth PF03088.14 001126348.1_39523001_1 - 0.002 18.1 0.0 0.0059 16.6 0.0 1.7 1 0 0 1 1 1 1 Strictosidine synthase Ig_2 PF13895.4 001139453.1_39523001_1 - 2.5e-20 72.5 1.5 6.4e-12 45.5 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001139453.1_39523001_1 - 1.2e-15 57.7 0.2 1.9e-07 31.5 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.3 001139453.1_39523001_1 - 3.2e-06 27.3 0.0 0.0009 19.4 0.0 2.4 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain ig PF00047.23 001139453.1_39523001_1 - 5.9e-06 26.2 2.0 0.0066 16.5 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001139453.1_39523001_1 - 0.00046 20.1 0.0 0.5 10.3 0.0 3.1 2 2 0 2 2 2 2 Immunoglobulin I-set domain Ig_5 PF16681.3 001139453.1_39523001_1 - 0.00099 19.4 0.0 0.093 13.0 0.0 2.4 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.15 001139453.1_39523001_1 - 0.0039 17.2 2.0 7.8 6.6 0.1 3.8 2 2 1 3 3 3 1 Immunoglobulin V-set domain C1-set PF07654.13 001139453.1_39523001_1 - 0.014 15.7 0.2 0.14 12.6 0.1 2.4 2 0 0 2 2 2 0 Immunoglobulin C1-set domain DUF202 PF02656.13 001139453.1_39523001_1 - 0.065 13.6 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF202) EF-hand_1 PF00036.30 001145182.1_39522001_2 - 2.8e-12 45.1 4.4 3.6e-05 22.9 0.6 4.2 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 001145182.1_39522001_2 - 5.9e-12 45.7 3.2 7.2e-06 26.3 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001145182.1_39522001_2 - 5e-09 35.3 10.8 3.1e-06 26.6 0.5 4.0 5 0 0 5 5 5 2 EF-hand domain EF-hand_8 PF13833.4 001145182.1_39522001_2 - 8.9e-08 31.7 4.4 0.0044 16.6 0.1 3.5 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_11 PF08976.9 001145182.1_39522001_2 - 1.9e-05 25.3 0.1 0.00015 22.4 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain EF-hand_5 PF13202.4 001145182.1_39522001_2 - 8.7e-05 21.7 2.2 0.00023 20.4 0.9 2.4 2 0 0 2 2 2 1 EF hand UPF0154 PF03672.11 001145182.1_39522001_2 - 0.012 15.5 0.0 4.1 7.4 0.0 2.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0154) EF-hand_9 PF14658.4 001145182.1_39522001_2 - 0.014 15.6 0.0 0.79 10.0 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain GPHH PF16905.3 001145182.1_39522001_2 - 0.073 12.8 0.0 12 5.6 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated Dysbindin PF04440.14 001126349.1_39523001_1 - 2.5e-64 215.7 5.8 2.5e-64 215.7 5.8 1.7 2 0 0 2 2 2 1 Dysbindin (Dystrobrevin binding protein 1) DUF2730 PF10805.6 001126349.1_39523001_1 - 0.017 15.1 0.2 0.017 15.1 0.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) Peptidase_S46 PF10459.7 001126349.1_39523001_1 - 0.027 13.0 6.3 0.033 12.7 6.3 1.1 1 0 0 1 1 1 0 Peptidase S46 NPV_P10 PF05531.10 001126349.1_39523001_1 - 0.053 13.9 0.2 0.053 13.9 0.2 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Exonuc_VII_L PF02601.13 001126349.1_39523001_1 - 1.4 8.3 14.1 2.5 7.5 14.1 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit Glutaredoxin2_C PF04399.11 001126349.1_39523001_1 - 1.7 8.4 5.5 1.3 8.8 0.1 2.4 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain DUF4407 PF14362.4 001126349.1_39523001_1 - 2.6 7.2 6.0 3.9 6.6 6.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-C4pol PF14260.4 001126349.1_39523001_1 - 4.6 7.6 5.9 1.4 9.3 0.2 2.7 2 1 1 3 3 3 0 C4-type zinc-finger of DNA polymerase delta OmpH PF03938.12 001126349.1_39523001_1 - 7.9 6.3 19.6 19 5.1 0.1 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Ig_2 PF13895.4 001139454.1_39522001_1 - 3.7e-21 75.1 2.2 4.8e-11 42.7 0.1 2.3 1 1 1 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001139454.1_39522001_1 - 1.7e-15 57.2 1.1 1.1e-06 29.0 0.4 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001139454.1_39522001_1 - 5.5e-10 39.1 1.5 0.00083 19.3 0.4 3.0 2 2 0 2 2 2 2 Immunoglobulin domain Ig_4 PF16680.3 001139454.1_39522001_1 - 3.4e-07 30.4 0.7 0.0027 17.9 0.2 2.3 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.3 001139454.1_39522001_1 - 4.6e-07 30.0 0.6 0.00012 22.2 0.1 2.3 2 0 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain I-set PF07679.14 001139454.1_39522001_1 - 6.8e-07 29.1 2.9 0.0021 18.0 0.4 3.1 2 2 0 2 2 2 2 Immunoglobulin I-set domain C2-set PF05790.13 001139454.1_39522001_1 - 0.00087 19.3 0.0 0.042 13.9 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin C2-set domain V-set PF07686.15 001139454.1_39522001_1 - 0.0022 18.0 9.2 0.88 9.6 0.1 4.3 3 2 2 5 5 5 2 Immunoglobulin V-set domain Adipogenin PF15202.4 001112822.1_39521001_1 - 1.8e-46 155.9 5.4 2e-46 155.8 5.4 1.0 1 0 0 1 1 1 1 Adipogenin Innexin PF00876.16 001112822.1_39521001_1 - 0.025 13.7 0.1 0.025 13.7 0.1 1.0 1 0 0 1 1 1 0 Innexin Sugar_tr PF00083.22 001112822.1_39521001_1 - 0.074 11.8 0.0 0.085 11.6 0.0 1.0 1 0 0 1 1 1 0 Sugar (and other) transporter EF-hand_7 PF13499.4 001145183.1_39522001_2 - 6e-08 32.9 0.1 0.00072 19.8 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001145183.1_39522001_2 - 7e-08 31.7 1.8 2.5e-05 23.7 0.4 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.30 001145183.1_39522001_2 - 1.4e-07 30.4 5.4 1.9e-05 23.8 0.9 4.0 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.4 001145183.1_39522001_2 - 3.7e-05 23.3 2.4 0.0046 16.6 0.4 3.6 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.4 001145183.1_39522001_2 - 0.00031 20.0 1.1 0.00031 20.0 1.1 2.1 2 0 0 2 2 2 1 EF hand Pkinase PF00069.23 001146090.1_39523001_1 - 3.8e-65 219.7 0.0 5e-65 219.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001146090.1_39523001_1 - 1.8e-21 76.5 0.0 2.6e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001146090.1_39523001_1 - 4.3e-09 36.0 0.0 6.3e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001146090.1_39523001_1 - 6.1e-07 28.9 0.0 1.3e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001146090.1_39523001_1 - 0.043 13.6 0.1 0.043 13.6 0.1 2.4 3 0 0 3 3 3 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.9 001146090.1_39523001_1 - 0.19 10.6 0.0 0.29 10.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RRM_1 PF00076.20 001126353.1_39522001_1 - 2e-29 101.1 1.3 1.1e-14 53.8 0.1 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001126353.1_39522001_1 - 3.8e-08 33.0 0.0 0.00034 20.3 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.4 001126353.1_39522001_1 - 5.8e-08 32.3 0.0 0.0049 16.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.4 001126353.1_39522001_1 - 0.0042 16.8 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4523) Nup35_RRM_2 PF14605.4 001126353.1_39522001_1 - 0.18 11.7 0.0 2.3 8.1 0.0 2.2 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif zf-CCHC PF00098.21 001126353.1_39522001_3 - 0.24 11.4 4.7 7.9 6.6 0.3 2.9 2 0 0 2 2 2 0 Zinc knuckle Perilipin PF03036.14 001104932.1_39523001_3 - 2.2e-165 550.4 9.5 2.6e-165 550.1 9.5 1.0 1 0 0 1 1 1 1 Perilipin family HSP9_HSP12 PF04119.10 001104932.1_39523001_3 - 0.12 12.7 2.7 4.8 7.5 0.0 3.5 3 1 0 3 3 3 0 Heat shock protein 9/12 V-SNARE_C PF12352.6 001104932.1_39523001_3 - 0.17 12.0 3.7 0.17 12.1 1.0 2.3 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus LRR_9 PF14580.4 001126355.1_39522001_1 - 2.5e-95 316.8 1.6 3.2e-95 316.4 1.6 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.5 001126355.1_39522001_1 - 8.9e-07 29.0 9.7 0.0007 19.8 2.5 3.0 3 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001126355.1_39522001_1 - 6.2e-06 25.7 3.7 3.1e-05 23.5 2.6 2.3 1 1 1 2 2 2 2 Leucine rich repeat NADH_B2 PF14813.4 001126355.1_39522001_2 - 1.1 8.9 4.5 2 8.2 4.5 1.3 1 0 0 1 1 1 0 NADH dehydrogenase 1 beta subcomplex subunit 2 Abhydrolase_1 PF00561.18 001104933.1_39523001_2 - 1.4e-19 70.6 0.0 2.1e-19 70.1 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001104933.1_39523001_2 - 7.5e-18 65.8 0.1 1.1e-17 65.3 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 001104933.1_39523001_2 - 1.4e-10 40.7 0.0 2.2e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.12 001104933.1_39523001_2 - 0.0028 16.3 0.0 0.0074 14.9 0.0 1.6 2 0 0 2 2 2 1 Ndr family DUF1071 PF06378.9 001104933.1_39523001_2 - 0.13 11.7 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1071) DUF2251 PF10008.7 001104933.1_39523001_2 - 0.15 12.0 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2251) Tetraspannin PF00335.18 001282247.1_39524001_1 - 1.3e-48 165.5 23.4 1.8e-48 165.0 23.4 1.2 1 0 0 1 1 1 1 Tetraspanin family MT-A70 PF05063.12 001267877.1_39523001_1 - 2.2e-39 135.0 0.1 3.6e-39 134.3 0.1 1.4 1 0 0 1 1 1 1 MT-A70 HDAC4_Gln PF12203.6 001246262.1_39524001_1 - 3.9e-32 110.2 43.7 3.9e-32 110.2 43.7 3.6 3 0 0 3 3 3 1 Glutamine rich N terminal domain of histone deacetylase 4 RIIa PF02197.15 001009738.1_39522001_3 - 3e-15 55.5 0.2 4.5e-15 54.9 0.2 1.3 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit IQ PF00612.25 001009738.1_39522001_3 - 6.3e-06 25.4 0.0 1.1e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 IQ calmodulin-binding motif GSHPx PF00255.17 001267883.1_39523001_1 - 1e-43 147.1 0.3 1.7e-43 146.4 0.3 1.3 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.19 001267883.1_39523001_1 - 0.12 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family UDPGT PF00201.16 001205146.2_39525001_3 - 1.1e-225 750.1 0.0 1.3e-225 749.8 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001205146.2_39525001_3 - 2.4e-06 27.5 0.0 5e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 001205146.2_39525001_3 - 0.099 12.5 0.2 0.24 11.2 0.2 1.7 1 1 0 1 1 1 0 Glycosyltransferase Family 4 N_NLPC_P60 PF12912.5 001205146.2_39525001_3 - 0.11 12.7 0.1 1.1 9.4 0.1 2.4 2 1 0 2 2 2 0 NLPC_P60 stabilising domain, N term IRF PF00605.15 001009740.1_39523001_1 - 1.1e-40 138.0 0.7 1.8e-40 137.3 0.7 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor Heme_oxygenase PF01126.18 001009740.1_39523001_1 - 0.046 13.4 0.0 0.076 12.7 0.0 1.2 1 0 0 1 1 1 0 Heme oxygenase SMN PF06003.10 001009740.1_39523001_1 - 7.7 5.5 10.8 3.1 6.8 6.8 2.1 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) IRF-3 PF10401.7 001009741.1_39523001_1 - 4.9e-66 221.8 0.0 6.7e-66 221.4 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.15 001009741.1_39523001_1 - 1.7e-38 131.0 0.1 3.2e-38 130.1 0.1 1.5 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor IceA2 PF05862.9 001009741.1_39523001_1 - 0.18 11.6 0.0 0.45 10.4 0.0 1.6 1 0 0 1 1 1 0 Helicobacter pylori IceA2 protein UDPGT PF00201.16 001205147.1_39525001_1 - 1.9e-237 788.9 0.0 2.2e-237 788.6 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001205147.1_39525001_1 - 3e-06 27.2 0.0 4.9e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain PMP22_Claudin PF00822.18 001185016.1_39522001_1 - 1.6e-53 180.9 10.2 1.8e-53 180.7 10.2 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001185016.1_39522001_1 - 3.4e-12 46.4 10.7 6.2e-11 42.3 10.4 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction SUR7 PF06687.10 001185016.1_39522001_1 - 0.001 18.6 3.9 0.001 18.6 3.9 2.2 1 1 1 2 2 2 1 SUR7/PalI family Amastin PF07344.9 001185016.1_39522001_1 - 0.0028 17.4 5.3 0.0028 17.4 5.3 1.8 1 1 1 2 2 2 1 Amastin surface glycoprotein DUF898 PF05987.11 001185016.1_39522001_1 - 0.15 11.0 7.7 0.018 14.0 1.9 1.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) DUF4134 PF13572.4 001185016.1_39522001_1 - 0.73 10.0 5.7 0.18 12.0 2.4 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4134) DUF4064 PF13273.4 001185016.1_39522001_1 - 0.88 9.8 13.6 3.2 8.0 10.6 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) DUF2613 PF11021.6 001185016.1_39522001_1 - 0.93 9.5 4.2 0.62 10.1 1.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2613) ThrE PF06738.10 001185016.1_39522001_1 - 4.1 6.6 11.3 0.05 12.8 1.2 2.5 2 1 0 3 3 3 0 Putative threonine/serine exporter UDPGT PF00201.16 001205148.1_39525001_1 - 8.1e-240 796.7 0.1 9.5e-240 796.4 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001205148.1_39525001_1 - 2.6e-06 27.4 0.0 5e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 001205148.1_39525001_1 - 0.0097 15.8 0.1 0.032 14.1 0.1 1.7 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Hydrolase PF00702.24 001126360.1_39522001_1 - 3.5e-17 63.2 0.0 4.7e-17 62.9 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 001126360.1_39522001_1 - 6.9e-12 46.0 0.0 1.2e-11 45.2 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.10 001126360.1_39522001_1 - 2.2e-05 23.9 0.0 6e-05 22.4 0.0 1.6 1 1 0 1 1 1 1 Putative Phosphatase HAD_2 PF13419.4 001126360.1_39522001_1 - 2.4e-05 24.4 0.0 0.024 14.6 0.0 2.4 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase UMPH-1 PF05822.10 001126360.1_39522001_1 - 5.3e-05 22.7 0.0 8.4e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) StbA PF06406.9 001126360.1_39522001_1 - 0.07 12.2 0.0 0.16 11.0 0.0 1.5 2 0 0 2 2 2 0 StbA protein UDPGT PF00201.16 001205149.1_39525001_3 - 6e-239 793.8 0.0 7.1e-239 793.6 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001205149.1_39525001_3 - 2.7e-06 27.3 0.0 4.9e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 001205149.1_39525001_3 - 0.025 14.5 0.0 0.13 12.1 0.0 2.0 1 1 0 1 1 1 0 Glycosyltransferase Family 4 DFP PF04127.13 001126363.1_39522001_1 - 1.5e-10 41.1 0.0 4.6e-07 29.7 0.0 2.2 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein UDPGT PF00201.16 001205151.1_39525001_1 - 7.8e-256 849.5 0.1 9.4e-256 849.2 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001205151.1_39525001_1 - 1.1e-05 25.3 0.0 1.9e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_4_2 PF13477.4 001205151.1_39525001_1 - 0.019 14.9 0.0 0.23 11.3 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase 4-like MHC_II_alpha PF00993.18 001308597.1_39522001_3 - 3.1e-33 113.2 0.1 4.4e-33 112.7 0.1 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001308597.1_39522001_3 - 3e-29 100.1 0.5 6.8e-29 98.9 0.5 1.6 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001308597.1_39522001_3 - 9.1e-25 86.8 0.0 1.5e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001308597.1_39522001_3 - 1e-05 25.9 0.0 1.9e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001308597.1_39522001_3 - 0.00027 21.1 0.0 0.0007 19.8 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin domain Marek_A PF02124.13 001308597.1_39522001_3 - 0.055 13.2 0.0 0.086 12.5 0.0 1.2 1 0 0 1 1 1 0 Marek's disease glycoprotein A I-set PF07679.14 001308597.1_39522001_3 - 0.064 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain PAS_11 PF14598.4 001130932.1_39526001_1 - 1.5e-20 73.3 0.0 1.5e-20 73.3 0.0 3.6 5 0 0 5 5 5 2 PAS domain PAS_3 PF08447.10 001130932.1_39526001_1 - 4.7e-18 65.1 1.5 8.7e-16 57.8 0.1 2.8 3 0 0 3 3 3 2 PAS fold PAS PF00989.23 001130932.1_39526001_1 - 1.6e-10 40.9 0.0 8.3e-08 32.1 0.0 3.5 3 0 0 3 3 3 1 PAS fold HLH PF00010.24 001130932.1_39526001_1 - 1.3e-09 37.8 0.6 3.5e-09 36.4 0.6 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 001130932.1_39526001_1 - 0.00012 22.2 0.0 0.00061 19.9 0.0 2.3 2 0 0 2 2 2 1 PAS domain DUF3533 PF12051.6 001130932.1_39526001_1 - 2 7.1 11.5 1.4 7.6 9.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3533) Ribosomal_L23eN PF03939.11 001177677.1_39521001_1 - 3.5e-28 97.5 17.1 3.5e-28 97.5 17.1 2.0 3 0 0 3 3 3 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.18 001177677.1_39521001_1 - 2.9e-16 59.5 3.2 2.9e-16 59.5 3.2 2.6 2 2 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L6 PF00347.21 001177677.1_39521001_1 - 0.039 14.5 1.2 0.065 13.8 0.1 1.8 2 0 0 2 2 2 0 Ribosomal protein L6 SGL PF08450.10 001130935.1_39522001_1 - 9.5e-77 257.8 0.1 1.1e-76 257.6 0.1 1.0 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region NHL PF01436.19 001130935.1_39522001_1 - 0.056 13.4 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 NHL repeat Lactonase PF10282.7 001130935.1_39522001_1 - 0.098 11.8 0.0 0.26 10.4 0.0 1.6 1 1 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Acyl-CoA_dh_C PF12806.5 001130935.1_39522001_1 - 0.19 11.7 0.0 0.29 11.1 0.0 1.2 1 0 0 1 1 1 0 Acetyl-CoA dehydrogenase C-terminal like Ras PF00071.20 001126366.1_39522001_1 - 2e-35 121.7 0.0 2.3e-35 121.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001126366.1_39522001_1 - 2.2e-17 63.2 0.0 3.1e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001126366.1_39522001_1 - 0.036 13.4 0.0 0.039 13.3 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_16 PF13191.4 001126366.1_39522001_1 - 0.11 12.8 0.0 0.19 12.0 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Josephin PF02099.15 001130936.1_39522001_1 - 4e-55 186.2 0.0 6.9e-55 185.4 0.0 1.4 1 0 0 1 1 1 1 Josephin SUIM_assoc PF16619.3 001130936.1_39522001_1 - 2.4e-14 53.1 0.1 5.8e-14 51.8 0.1 1.7 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 UIM PF02809.18 001130936.1_39522001_1 - 7.2e-09 34.8 17.2 5.4e-05 22.7 0.6 3.6 3 0 0 3 3 3 2 Ubiquitin interaction motif Peptidase_M10 PF00413.22 001136491.1_39523001_1 - 1.6e-62 209.9 0.0 2.1e-62 209.5 0.0 1.1 1 0 0 1 1 1 1 Matrixin PG_binding_1 PF01471.16 001136491.1_39523001_1 - 1.6e-07 31.3 0.0 2.4e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Peptidase_M54 PF07998.9 001136491.1_39523001_1 - 0.0013 18.6 0.0 0.0025 17.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M54 Reprolysin_5 PF13688.4 001136491.1_39523001_1 - 0.012 15.6 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 001136491.1_39523001_1 - 0.018 15.4 0.2 0.03 14.7 0.2 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.6 001136491.1_39523001_1 - 0.025 14.1 0.0 0.042 13.3 0.0 1.4 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Metallopep PF12044.6 001136491.1_39523001_1 - 0.029 12.9 0.0 0.044 12.3 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Astacin PF01400.22 001136491.1_39523001_1 - 0.055 12.9 1.4 1.2 8.6 0.2 2.5 2 1 1 3 3 3 0 Astacin (Peptidase family M12A) Peptidase_M66 PF10462.7 001136491.1_39523001_1 - 0.076 11.8 0.1 0.11 11.2 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_4 PF13583.4 001136491.1_39523001_1 - 0.089 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.3 001136491.1_39523001_1 - 0.1 11.6 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Met-zincin Gal-bind_lectin PF00337.20 001009238.1_39521001_3 - 2.6e-20 72.2 0.0 3.2e-20 71.9 0.0 1.1 1 0 0 1 1 1 1 Galactoside-binding lectin IL15 PF02372.13 001256817.1_39521001_1 - 1.3e-08 34.9 0.1 1.5e-08 34.6 0.1 1.1 1 0 0 1 1 1 1 Interleukin 15 EIF_2_alpha PF07541.10 001256817.1_39521001_1 - 0.12 12.3 0.1 0.2 11.6 0.1 1.4 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit Trypsin PF00089.24 001093787.1_39522001_1 - 2.7e-71 239.7 0.1 3.2e-71 239.5 0.1 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001093787.1_39522001_1 - 2.5e-06 28.3 0.0 4.6e-06 27.5 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001093787.1_39522001_1 - 0.0013 19.0 0.2 0.015 15.6 0.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1986) p450 PF00067.20 001245972.1_39524001_3 - 3e-142 474.5 0.0 3.5e-142 474.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 LNS2 PF08235.11 001280700.1_39527001_3 - 2.1e-104 347.8 0.0 3.5e-104 347.1 0.0 1.4 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.12 001280700.1_39527001_3 - 1.8e-45 152.9 0.0 4e-45 151.8 0.0 1.6 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.3 001280700.1_39527001_3 - 5e-33 113.2 0.0 1.3e-32 111.9 0.0 1.8 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain DUF5005 PF16396.3 001280700.1_39527001_3 - 0.11 11.0 0.0 12 4.3 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF5005) Peptidase_M10 PF00413.22 001166179.1_39523001_1 - 6.6e-67 224.1 0.0 1.1e-66 223.4 0.0 1.4 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 001166179.1_39523001_1 - 1.2e-41 140.2 5.3 1.9e-10 40.4 0.0 4.4 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 001166179.1_39523001_1 - 1.1e-11 44.6 0.0 2e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_3 PF13582.4 001166179.1_39523001_1 - 0.00068 20.0 0.0 0.0013 19.1 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001166179.1_39523001_1 - 0.0062 16.1 0.0 0.0097 15.4 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.22 001166179.1_39523001_1 - 0.0087 15.6 0.1 2.9 7.3 0.0 2.2 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) DUF4953 PF16313.3 001166179.1_39523001_1 - 0.064 12.3 0.1 0.11 11.5 0.1 1.3 1 0 0 1 1 1 0 Met-zincin Reprolysin_5 PF13688.4 001166179.1_39523001_1 - 0.07 13.1 0.2 0.13 12.3 0.2 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 7tm_1 PF00001.19 001009760.1_39524001_3 - 6.8e-48 163.1 15.1 9.4e-48 162.6 15.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001009760.1_39524001_3 - 3.6e-11 42.8 11.5 7.6e-11 41.7 11.5 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.7 001009760.1_39524001_3 - 1.1e-05 24.8 14.9 1.6e-05 24.3 14.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001009760.1_39524001_3 - 0.00023 20.8 12.2 0.0014 18.3 12.2 2.0 1 1 0 1 1 1 1 Olfactory receptor Peptidase_M10 PF00413.22 001166180.1_39524001_1 - 1.7e-68 229.3 0.0 4.5e-68 227.9 0.0 1.7 1 1 0 1 1 1 1 Matrixin fn2 PF00040.17 001166180.1_39524001_1 - 6.5e-53 176.6 40.1 9.9e-19 67.2 5.2 3.7 3 0 0 3 3 3 3 Fibronectin type II domain Hemopexin PF00045.17 001166180.1_39524001_1 - 5.7e-45 150.9 9.1 4.3e-15 55.3 0.7 4.5 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 001166180.1_39524001_1 - 6.4e-08 32.6 0.0 1.7e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 001166180.1_39524001_1 - 0.004 16.7 0.0 1.5 8.2 0.0 2.4 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.4 001166180.1_39524001_1 - 0.037 14.4 0.1 0.068 13.6 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 001166180.1_39524001_1 - 0.05 13.6 0.1 0.085 12.9 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M66 PF10462.7 001166180.1_39524001_1 - 0.088 11.6 0.1 0.14 11.0 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_4 PF13583.4 001166180.1_39524001_1 - 0.1 12.1 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Endothelin PF00322.15 001280691.1_39524001_1 - 3.7e-19 67.9 18.6 2e-18 65.5 7.7 2.6 2 0 0 2 2 2 2 Endothelin family Trypsin PF00089.24 001163593.1_39525001_1 - 1e-65 221.5 0.0 1.4e-65 221.1 0.0 1.2 1 0 0 1 1 1 1 Trypsin Kringle PF00051.16 001163593.1_39525001_1 - 1.2e-21 76.7 1.6 1.2e-21 76.7 1.6 2.2 2 0 0 2 2 2 1 Kringle domain Trypsin_2 PF13365.4 001163593.1_39525001_1 - 0.0013 19.5 0.0 0.0033 18.2 0.0 1.6 2 0 0 2 2 2 1 Trypsin-like peptidase domain DUF316 PF03761.13 001163593.1_39525001_1 - 0.005 16.3 0.0 2.2 7.6 0.0 2.5 3 0 0 3 3 3 2 Chymotrypsin family Peptidase-S1 Metallophos PF00149.26 001252177.2_39523001_2 - 3.7e-22 79.7 0.0 5.1e-22 79.3 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PhoD PF09423.8 001252177.2_39523001_2 - 0.0095 14.8 0.0 0.45 9.3 0.0 2.1 2 0 0 2 2 2 2 PhoD-like phosphatase MIP PF00230.18 001009279.1_39523001_1 - 1.4e-73 247.2 16.3 1.8e-73 246.9 16.3 1.1 1 0 0 1 1 1 1 Major intrinsic protein IRF PF00605.15 001009751.1_39523001_1 - 6.6e-41 138.7 0.6 1.1e-40 138.1 0.6 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor IL4Ra_N PF09238.8 001252180.1_39524001_2 - 0.021 15.0 2.1 0.048 13.9 2.1 1.5 1 0 0 1 1 1 0 Interleukin-4 receptor alpha chain, N-terminal EpoR_lig-bind PF09067.8 001252180.1_39524001_2 - 0.41 10.7 2.2 0.95 9.6 2.2 1.5 1 0 0 1 1 1 0 Erythropoietin receptor, ligand binding Glyco_transf_6 PF03414.11 001009764.1_39523001_2 - 5.2e-155 514.9 4.8 6.1e-155 514.7 4.8 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 6 Lys PF00062.18 001306119.1_39521001_1 - 3.1e-57 192.0 3.6 3.6e-57 191.9 3.6 1.0 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family SLT PF01464.18 001306119.1_39521001_1 - 0.00021 20.8 0.0 0.0003 20.3 0.0 1.2 1 0 0 1 1 1 1 Transglycosylase SLT domain MHC_II_alpha PF00993.18 001308582.1_39522001_3 - 7.6e-36 121.5 0.0 1.1e-35 121.0 0.0 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001308582.1_39522001_3 - 1.5e-28 97.8 0.8 2.7e-28 97.0 0.8 1.5 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001308582.1_39522001_3 - 1.3e-24 86.4 0.0 2e-24 85.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001308582.1_39522001_3 - 2.5e-06 27.9 0.0 4e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001308582.1_39522001_3 - 0.0005 19.8 0.0 0.00073 19.3 0.0 1.2 1 0 0 1 1 1 1 Marek's disease glycoprotein A C2-set_2 PF08205.10 001308582.1_39522001_3 - 0.00086 19.2 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.14 001308582.1_39522001_3 - 0.15 12.0 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain SKG6 PF08693.8 001308582.1_39522001_3 - 0.3 10.4 2.5 0.58 9.5 2.5 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain LRR_8 PF13855.4 001163597.1_39522001_1 - 2.1e-34 116.9 61.2 1.9e-09 37.0 5.2 4.1 1 1 5 6 6 6 6 Leucine rich repeat LRR_4 PF12799.5 001163597.1_39522001_1 - 5.3e-20 71.0 26.1 2.4e-06 27.6 2.0 4.7 1 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001163597.1_39522001_1 - 1.4e-09 36.9 20.2 1.8 9.2 0.2 7.7 7 1 0 7 7 7 5 Leucine Rich Repeat LRR_6 PF13516.4 001163597.1_39522001_1 - 1.3e-06 27.8 24.8 3.6 7.7 0.4 7.5 7 0 0 7 7 7 6 Leucine Rich repeat 3Beta_HSD PF01073.17 001135932.1_39523001_1 - 1.2e-111 372.1 0.0 1.5e-111 371.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 001135932.1_39523001_1 - 6.1e-22 78.1 0.0 9e-22 77.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 001135932.1_39523001_1 - 1.9e-15 56.6 0.5 1.4e-14 53.7 0.5 2.0 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.3 001135932.1_39523001_1 - 2.5e-15 56.5 0.0 3.2e-14 52.9 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.13 001135932.1_39523001_1 - 8e-12 44.8 0.0 1.2e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.4 001135932.1_39523001_1 - 2.1e-08 34.2 0.0 3.1e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 001135932.1_39523001_1 - 7.3e-06 25.2 0.0 9.2e-06 24.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.8 001135932.1_39523001_1 - 8.4e-05 22.4 0.0 0.00015 21.6 0.0 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.11 001135932.1_39523001_1 - 0.0012 18.3 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family TIMP PF00965.15 001166187.1_39522001_1 - 1e-66 224.1 7.4 1.1e-66 223.9 7.4 1.0 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase Gelsolin PF00626.20 001246006.1_39525001_3 - 3.5e-108 353.5 0.0 3.7e-19 68.3 0.0 6.2 6 0 0 6 6 6 6 Gelsolin repeat UPAR_LY6 PF00021.19 001163606.1_39523001_3 - 2e-27 95.6 48.5 2.4e-13 50.5 9.9 3.1 3 0 0 3 3 3 3 u-PAR/Ly-6 domain Toxin_1 PF00087.19 001163606.1_39523001_3 - 0.62 10.2 44.1 0.045 13.9 7.5 3.9 3 0 0 3 3 3 0 Snake toxin Gal-bind_lectin PF00337.20 001009251.1_39521001_1 - 2.8e-38 130.3 0.1 3.3e-38 130.1 0.1 1.0 1 0 0 1 1 1 1 Galactoside-binding lectin DNA_pol3_beta PF00712.17 001009251.1_39521001_1 - 0.034 14.2 0.0 0.069 13.2 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase III beta subunit, N-terminal domain MH2 PF03166.12 001267886.1_39524001_1 - 1.7e-78 262.9 0.0 2.6e-78 262.4 0.0 1.3 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 001267886.1_39524001_1 - 3.9e-40 136.1 0.5 8.4e-40 135.0 0.5 1.6 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.7 001267886.1_39524001_1 - 0.034 13.8 0.0 0.062 13.0 0.0 1.3 1 0 0 1 1 1 0 Interferon-regulatory factor 3 Fumble PF03630.12 001142893.1_39523001_1 - 1.2e-103 346.7 0.0 1.5e-103 346.4 0.0 1.0 1 0 0 1 1 1 1 Fumble Pkinase PF00069.23 001142894.1_39523001_3 - 8.7e-65 218.6 0.0 1e-64 218.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001142894.1_39523001_3 - 2.1e-30 105.8 0.0 2.7e-30 105.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001142894.1_39523001_3 - 9.5e-05 21.7 0.4 0.00014 21.1 0.4 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001142894.1_39523001_3 - 0.012 15.4 0.4 0.043 13.6 0.0 1.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kinase-like PF14531.4 001142894.1_39523001_3 - 0.1 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like NAD_binding_8 PF13450.4 001142894.1_39523001_3 - 0.15 12.1 0.3 0.37 10.9 0.3 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain C2-set_2 PF08205.10 001024963.2_39523001_3 - 1.8e-19 69.4 0.0 5e-19 68.0 0.0 1.8 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 001024963.2_39523001_3 - 3.5e-10 39.9 0.3 1.1e-09 38.3 0.3 1.8 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001024963.2_39523001_3 - 4.6e-09 36.6 1.2 2.9e-05 24.5 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001024963.2_39523001_3 - 5.5e-07 29.7 0.3 0.0005 20.2 0.1 2.9 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001024963.2_39523001_3 - 1.3e-06 28.4 1.4 5.4e-05 23.2 0.1 2.9 2 1 1 3 3 3 1 Immunoglobulin domain I-set PF07679.14 001024963.2_39523001_3 - 2.7e-06 27.2 0.0 0.0017 18.2 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain C1-set PF07654.13 001024963.2_39523001_3 - 2.4e-05 24.6 0.0 9.2e-05 22.7 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin C1-set domain V-set PF07686.15 001038016.1_39523001_2 - 5.7e-09 36.0 3.9 5.1e-08 32.9 0.1 2.9 3 0 0 3 3 3 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001038016.1_39523001_2 - 3.6e-07 30.6 3.5 0.011 16.2 0.0 3.0 3 1 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 001038016.1_39523001_2 - 2.3e-05 24.5 4.1 0.073 13.3 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.10 001038016.1_39523001_2 - 0.0038 17.1 0.2 0.0093 15.9 0.2 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.14 001038016.1_39523001_2 - 0.0049 16.8 0.0 0.017 15.0 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 001038016.1_39523001_2 - 0.019 15.0 4.3 0.085 12.9 0.0 3.2 3 1 0 3 3 3 0 Immunoglobulin domain DUF4307 PF14155.4 001038016.1_39523001_2 - 0.046 13.4 0.0 0.14 11.8 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4307) CcmH PF03918.12 001038016.1_39523001_2 - 0.099 11.8 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Cytochrome C biogenesis protein Transferrin PF00405.15 001024862.1_39525001_1 - 1.9e-261 865.3 9.6 1.8e-176 586.0 0.1 2.0 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 001024862.1_39525001_1 - 4.5e-11 42.7 0.0 0.00033 20.2 0.0 2.7 2 2 0 2 2 2 2 ABC transporter, phosphonate, periplasmic substrate-binding protein TGFb_propeptide PF00688.16 001308564.1_39524001_2 - 2.3e-93 312.3 0.0 3.3e-93 311.8 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001308564.1_39524001_2 - 3.1e-36 124.3 0.7 6.2e-36 123.3 0.7 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain SCAN PF02023.15 001246236.1_39525001_2 - 9.4e-40 134.2 0.4 1.7e-39 133.4 0.4 1.4 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 001246236.1_39525001_2 - 1.8e-22 78.3 30.9 2.5e-05 24.3 2.2 5.6 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001246236.1_39525001_2 - 6.2e-15 54.5 29.9 0.0024 18.4 1.7 5.8 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001246236.1_39525001_2 - 1.7e-11 43.9 33.9 0.00075 19.7 0.1 7.2 7 0 0 7 7 7 4 Zinc-finger double domain KRAB PF01352.25 001246236.1_39525001_2 - 8.8e-06 25.2 0.0 1.9e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 KRAB box zf-Di19 PF05605.10 001246236.1_39525001_2 - 4.5e-05 23.5 13.7 0.00021 21.4 0.3 3.3 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 001246236.1_39525001_2 - 0.0034 17.5 10.9 2.5 8.4 0.0 5.3 5 0 0 5 5 5 1 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 001246236.1_39525001_2 - 0.0039 17.1 16.7 0.023 14.7 0.5 4.3 4 1 0 4 4 4 1 Zinc ribbon domain CpXC PF14353.4 001246236.1_39525001_2 - 0.011 15.6 7.7 3.7 7.5 0.0 4.0 1 1 2 4 4 4 0 CpXC protein DUF2039 PF10217.7 001246236.1_39525001_2 - 0.019 15.2 0.1 0.062 13.5 0.1 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) ARS2 PF04959.11 001246236.1_39525001_2 - 0.055 13.7 5.1 0.36 11.0 0.2 2.8 3 0 0 3 3 3 0 Arsenite-resistance protein 2 zf-C2H2_6 PF13912.4 001246236.1_39525001_2 - 0.07 13.0 0.1 0.07 13.0 0.1 6.0 5 1 0 5 5 5 0 C2H2-type zinc finger Cys_rich_CPXG PF14255.4 001246236.1_39525001_2 - 0.11 12.3 1.1 1.3 8.8 0.1 3.2 3 0 0 3 3 3 0 Cysteine-rich CPXCG C1_4 PF07975.10 001246236.1_39525001_2 - 0.16 12.1 15.0 11 6.2 5.7 4.1 3 1 1 4 4 4 0 TFIIH C1-like domain GAGA PF09237.9 001246236.1_39525001_2 - 0.17 11.5 0.1 0.17 11.5 0.1 3.4 2 1 1 3 3 3 0 GAGA factor A2L_zn_ribbon PF08792.8 001246236.1_39525001_2 - 0.25 11.0 7.7 6.6 6.4 0.1 3.6 3 0 0 3 3 3 0 A2L zinc ribbon domain zf-C2H2_8 PF15909.3 001246236.1_39525001_2 - 0.25 11.5 10.2 0.97 9.6 0.9 3.2 2 1 1 3 3 3 0 C2H2-type zinc ribbon zinc_ribbon_15 PF17032.3 001246236.1_39525001_2 - 0.25 12.0 10.4 1.1 9.9 1.4 3.4 2 1 1 3 3 3 0 zinc-ribbon family ADK_lid PF05191.12 001246236.1_39525001_2 - 0.35 10.8 7.4 0.31 11.0 0.2 3.5 2 1 1 3 3 3 0 Adenylate kinase, active site lid FOXP-CC PF16159.3 001246236.1_39525001_2 - 1.2 9.7 6.2 21 5.7 0.0 3.0 2 1 1 3 3 3 0 FOXP coiled-coil domain Nudix_N_2 PF14803.4 001246236.1_39525001_2 - 1.3 8.8 7.9 13 5.7 0.0 4.2 4 0 0 4 4 4 0 Nudix N-terminal zinc_ribbon_4 PF13717.4 001246236.1_39525001_2 - 1.9 8.3 13.9 8.8 6.2 0.0 4.9 6 0 0 6 6 4 0 zinc-ribbon domain HypA PF01155.17 001246236.1_39525001_2 - 2.3 8.1 10.1 1.3e+02 2.5 0.8 3.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C1_1 PF00130.20 001246236.1_39525001_2 - 5.8 6.7 13.1 2.3 8.0 0.5 4.2 2 2 3 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PMP22_Claudin PF00822.18 001185018.1_39522001_1 - 2e-54 183.8 10.8 2.3e-54 183.6 10.8 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001185018.1_39522001_1 - 7.4e-13 48.5 9.8 2e-11 43.9 9.8 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Clc-like PF07062.10 001185018.1_39522001_1 - 0.026 13.9 0.3 0.026 13.9 0.3 2.3 1 1 0 2 2 2 0 Clc-like OppC_N PF12911.5 001185018.1_39522001_1 - 0.27 11.2 0.1 0.27 11.2 0.1 2.3 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C DUF4064 PF13273.4 001185018.1_39522001_1 - 3 8.1 10.1 2.8 8.2 6.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) Lys PF00062.18 001185019.1_39522001_1 - 2.4e-41 140.7 0.9 2.9e-41 140.5 0.9 1.1 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family Cyt-b5 PF00173.26 001166191.1_39521001_1 - 1.3e-22 79.6 0.0 1.7e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Pox_EPC_I2-L1 PF12575.6 001166191.1_39521001_1 - 0.15 12.1 0.1 0.36 10.9 0.1 1.6 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 IL1 PF00340.17 001009263.2_39522001_2 - 1.3e-35 121.6 0.8 2.5e-35 120.6 0.8 1.4 1 0 0 1 1 1 1 Interleukin-1 / 18 Globin PF00042.20 001166192.1_39522001_1 - 3e-25 88.8 0.0 4.8e-25 88.1 0.0 1.3 1 0 0 1 1 1 1 Globin CppA_N PF14506.4 001166192.1_39522001_1 - 0.019 14.9 0.0 0.025 14.5 0.0 1.2 1 0 0 1 1 1 0 CppA N-terminal eIF-5a PF01287.18 001166193.1_39521001_1 - 6.4e-26 90.1 0.2 9.5e-26 89.6 0.2 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.10 001166193.1_39521001_1 - 0.0038 17.1 0.0 0.0057 16.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain LRV_FeS PF05484.9 001166193.1_39521001_2 - 0.027 14.4 0.7 0.059 13.2 0.7 1.6 1 0 0 1 1 1 0 LRV protein FeS4 cluster RRM_1 PF00076.20 001166194.1_39522001_1 - 1.2e-62 207.6 0.1 1.1e-19 69.8 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001166194.1_39522001_1 - 5.9e-12 45.2 0.0 0.00055 19.4 0.0 3.1 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.10 001166194.1_39522001_1 - 1.9e-05 24.7 0.0 0.063 13.4 0.0 2.9 3 0 0 3 3 3 2 BRCA1-associated protein 2 RRM_3 PF08777.9 001166194.1_39522001_1 - 0.00032 20.6 0.0 0.085 12.8 0.0 2.5 2 0 0 2 2 2 1 RNA binding motif RRM_7 PF16367.3 001166194.1_39522001_1 - 0.00043 20.2 0.0 0.2 11.6 0.0 3.3 3 0 0 3 3 3 1 RNA recognition motif RRM_occluded PF16842.3 001166194.1_39522001_1 - 0.0014 18.3 0.0 1.1 9.0 0.0 3.1 3 1 0 3 3 3 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.4 001166194.1_39522001_1 - 0.049 13.5 0.0 1.5 8.7 0.0 2.7 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif E2 PF08199.9 001166194.1_39522001_1 - 0.11 12.3 0.0 0.33 10.8 0.0 1.8 1 0 0 1 1 1 0 Bacteriophage E2-like protein SRF-TF PF00319.16 001159277.1_39523001_1 - 3.6e-24 83.8 0.4 6.3e-24 83.1 0.4 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 001159277.1_39523001_1 - 3.2e-16 58.9 1.3 5e-16 58.3 0.1 2.0 2 0 0 2 2 2 1 Holliday junction regulator protein family C-terminal repeat PCI PF01399.25 001162562.1_39522001_1 - 5.5e-08 33.1 1.3 9.5e-08 32.4 0.2 1.9 2 0 0 2 2 2 1 PCI domain DUF4464 PF14713.4 001162562.1_39522001_1 - 0.21 11.0 2.8 0.19 11.1 1.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4464) Band_3_cyto PF07565.11 001162562.1_39522001_1 - 0.21 11.2 5.6 0.66 9.6 5.6 1.6 1 1 0 1 1 1 0 Band 3 cytoplasmic domain eIF-6 PF01912.16 001162563.1_39522001_1 - 9.7e-81 269.7 0.5 3.4e-80 268.0 0.1 1.8 2 0 0 2 2 2 1 eIF-6 family G6PD_C PF02781.14 001093780.1_39525001_2 - 2e-111 371.7 0.0 3.9e-111 370.8 0.0 1.4 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.20 001093780.1_39525001_2 - 1.7e-29 103.6 0.0 6.9e-29 101.6 0.0 1.9 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain G6PD_N PF00479.20 001093780.1_39525001_3 - 1.2e-18 68.3 0.0 1.8e-18 67.7 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Thyroglobulin_1 PF00086.16 001162564.1_39523001_2 - 4.6e-11 42.1 4.3 4.6e-11 42.1 4.3 2.0 1 1 1 2 2 2 1 Thyroglobulin type-1 repeat DUF3551 PF12071.6 001162564.1_39523001_2 - 0.013 15.4 3.9 0.029 14.3 3.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3551) EphA2_TM PF14575.4 001162564.1_39523001_2 - 0.044 14.5 0.7 0.18 12.5 0.2 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DAG1 PF05454.9 001162564.1_39523001_2 - 0.074 12.3 0.2 0.15 11.3 0.2 1.4 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Deltameth_res PF16020.3 001162564.1_39523001_2 - 0.11 12.3 0.1 25 4.7 0.0 2.8 3 0 0 3 3 3 0 Deltamethrin resistance ASFV_J13L PF05568.9 001162564.1_39523001_2 - 0.92 9.1 5.3 1.4 8.5 0.3 2.4 2 0 0 2 2 2 0 African swine fever virus J13L protein DUF2749 PF10907.6 001162564.1_39523001_2 - 1.9 8.6 6.5 0.22 11.6 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) Somatostatin PF03002.13 001143891.2_39521001_3 - 6e-12 45.2 5.4 1e-11 44.4 5.4 1.4 1 0 0 1 1 1 1 Somatostatin/Cortistatin family FGF PF00167.16 001162565.1_39522001_1 - 2.7e-40 137.2 0.0 3.6e-40 136.8 0.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 001162565.1_39522001_1 - 0.014 15.5 0.0 0.032 14.3 0.0 1.6 2 0 0 2 2 2 0 Fascin domain LIM PF00412.20 001166198.1_39522001_1 - 3.7e-48 161.4 69.3 3.1e-12 46.4 5.7 5.1 5 0 0 5 5 5 5 LIM domain Ureidogly_lyase PF04115.10 001166198.1_39522001_1 - 0.0041 16.8 2.8 1.7 8.2 0.0 3.4 1 1 2 4 4 4 2 Ureidoglycolate lyase zf-C3HC4_3 PF13920.4 001166198.1_39522001_1 - 3.3 7.5 70.0 0.49 10.2 6.0 6.8 5 4 0 5 5 5 0 Zinc finger, C3HC4 type (RING finger) SH3_1 PF00018.26 001166199.1_39524001_2 - 1.5e-43 146.0 5.5 8.5e-15 54.0 0.1 3.6 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.4 001166199.1_39524001_2 - 5.9e-40 134.8 0.9 1.1e-12 47.4 0.0 3.8 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.15 001166199.1_39524001_2 - 1.9e-34 117.0 1.9 3.2e-11 42.6 0.1 3.6 3 1 1 4 4 4 3 Variant SH3 domain SH2 PF00017.22 001166199.1_39524001_2 - 2.6e-23 81.7 0.2 5e-23 80.8 0.2 1.5 1 0 0 1 1 1 1 SH2 domain SH3_3 PF08239.9 001166199.1_39524001_2 - 1.6e-07 31.4 6.7 0.12 12.5 0.2 3.4 3 0 0 3 3 3 3 Bacterial SH3 domain hSH3 PF14603.4 001166199.1_39524001_2 - 0.00061 20.1 0.0 0.12 12.8 0.0 2.8 2 0 0 2 2 2 1 Helically-extended SH3 domain SH2_2 PF14633.4 001166199.1_39524001_2 - 0.0033 16.7 0.1 0.0096 15.2 0.1 1.6 1 1 0 1 1 1 1 SH2 domain LCAT PF02450.13 001162568.1_39523001_1 - 1.3e-113 380.0 0.0 7.9e-113 377.4 0.0 1.9 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.5 001162568.1_39523001_1 - 5.1e-05 23.9 0.8 6.3e-05 23.6 0.5 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 001162568.1_39523001_1 - 0.0034 16.5 0.0 0.0059 15.8 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.11 001162568.1_39523001_1 - 0.04 13.7 0.0 0.087 12.5 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase Abhydrolase_1 PF00561.18 001162568.1_39523001_1 - 0.073 12.6 0.0 0.28 10.6 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF1749 PF08538.8 001162568.1_39523001_1 - 0.11 11.5 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) AhpC-TSA PF00578.19 001166200.1_39522001_1 - 2.4e-42 143.6 0.0 5.3e-42 142.5 0.0 1.5 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.8 001166200.1_39522001_1 - 6e-17 61.6 0.0 8e-17 61.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.7 001166200.1_39522001_1 - 2e-13 49.8 0.0 3.5e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Metallophos PF00149.26 001166201.1_39524001_1 - 1.6e-19 71.1 1.1 2.1e-19 70.7 0.1 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Spp-24 PF07448.9 001166201.1_39524001_1 - 0.55 10.3 3.4 8.9 6.4 0.1 2.9 3 0 0 3 3 3 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Cyclin_N PF00134.21 001287473.1_39524001_3 - 5.4e-19 68.1 0.2 8.6e-19 67.4 0.2 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain V-set_2 PF15910.3 001009441.1_39522001_1 - 4.6e-15 55.6 1.6 7.5e-15 54.9 1.6 1.3 1 0 0 1 1 1 1 ICOS V-set domain V-set PF07686.15 001009441.1_39522001_1 - 4.8e-07 29.8 0.3 7.1e-07 29.2 0.3 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain DUF588 PF04535.10 001009441.1_39522001_1 - 0.034 13.8 0.0 0.058 13.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF588) Crisp PF08562.8 001185121.1_39523001_3 - 1.1e-20 73.8 21.4 2.5e-20 72.6 21.4 1.6 1 0 0 1 1 1 1 Crisp CAP PF00188.24 001185121.1_39523001_3 - 3.4e-19 69.8 2.6 5.5e-19 69.1 2.6 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DJ-1_PfpI PF01965.22 001162560.1_39522001_1 - 1.3e-05 25.0 0.3 4.3e-05 23.2 0.3 1.9 1 1 0 1 1 1 1 DJ-1/PfpI family Phage-A118_gp45 PF10653.7 001162560.1_39522001_1 - 0.19 11.7 0.0 0.37 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein gp45 of Bacteriophage A118 PseudoU_synth_1 PF01416.18 001163051.1_39523001_1 - 1.1e-14 54.6 0.0 7.9e-13 48.7 0.0 2.4 2 0 0 2 2 2 1 tRNA pseudouridine synthase Crust_neuro_H PF03858.11 001163051.1_39523001_1 - 0.042 14.5 0.0 0.1 13.3 0.0 1.6 1 0 0 1 1 1 0 Crustacean neurohormone H p450 PF00067.20 001077210.1_39524001_1 - 7.2e-140 466.6 0.7 8.2e-140 466.5 0.7 1.0 1 0 0 1 1 1 1 Cytochrome P450 Filament PF00038.19 001199070.1_39524001_1 - 1e-106 356.9 39.9 1.2e-106 356.7 39.9 1.0 1 0 0 1 1 1 1 Intermediate filament protein DUF5082 PF16888.3 001199070.1_39524001_1 - 0.1 12.8 19.9 0.025 14.8 6.3 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF5082) CREPT PF16566.3 001199070.1_39524001_1 - 0.47 10.5 20.9 2.9 7.9 2.4 3.4 3 0 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour DUF4407 PF14362.4 001199070.1_39524001_1 - 0.57 9.3 19.3 1.9 7.6 8.1 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.10 001199070.1_39524001_1 - 0.81 9.6 38.5 0.086 12.8 4.9 4.1 3 2 1 4 4 4 0 TPR/MLP1/MLP2-like protein Uso1_p115_C PF04871.11 001199070.1_39524001_1 - 0.96 9.7 22.5 0.57 10.4 4.7 3.0 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Baculo_PEP_C PF04513.10 001199070.1_39524001_1 - 1.1 9.1 21.3 5.7 6.8 0.8 3.3 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.10 001199070.1_39524001_1 - 1.1 9.1 18.0 2 8.3 1.2 3.8 2 2 1 4 4 4 0 Protein of unknown function (DUF1664) Spc7 PF08317.9 001199070.1_39524001_1 - 1.5 7.5 32.3 1.4 7.6 11.8 2.4 1 1 0 2 2 2 0 Spc7 kinetochore protein Thioredoxin PF00085.18 001163056.1_39523001_1 - 3.6e-09 36.4 0.0 6.2e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin DUF953 PF06110.9 001163057.1_39522001_2 - 6.5e-46 154.7 0.0 8e-46 154.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Glutaredoxin PF00462.22 001163057.1_39522001_2 - 0.082 13.0 0.7 8 6.6 0.3 2.6 2 1 0 2 2 2 0 Glutaredoxin Asp PF00026.21 001009782.1_39524001_1 - 1.5e-100 336.5 0.0 1.8e-100 336.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001009782.1_39524001_1 - 8.1e-13 48.9 0.3 1.8e-10 41.2 0.3 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001009782.1_39524001_1 - 1.7e-11 43.6 1.4 3e-11 42.8 1.4 1.4 1 0 0 1 1 1 1 A1 Propeptide YEATS PF03366.14 001163059.1_39522001_1 - 1.4e-34 117.7 0.4 2.7e-34 116.9 0.4 1.4 1 0 0 1 1 1 1 YEATS family SOGA PF11365.6 001163059.1_39522001_1 - 0.0091 17.0 3.4 0.017 16.1 3.4 1.5 1 0 0 1 1 1 1 Protein SOGA DUF1664 PF07889.10 001163059.1_39522001_1 - 0.2 11.5 1.3 0.33 10.8 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DivIC PF04977.13 001163059.1_39522001_1 - 0.85 9.3 4.0 1.8 8.3 4.0 1.6 1 0 0 1 1 1 0 Septum formation initiator fn2 PF00040.17 001093782.2_39522001_1 - 4.3e-28 97.2 20.4 6.8e-15 54.9 7.5 2.4 2 0 0 2 2 2 2 Fibronectin type II domain Pkinase_Tyr PF07714.15 001165890.1_39524001_1 - 1.4e-60 204.7 0.0 1.8e-60 204.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001165890.1_39524001_1 - 1.9e-55 188.0 0.0 2.7e-55 187.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RBD PF02196.13 001165890.1_39524001_1 - 4.1e-24 84.3 0.1 7.1e-24 83.6 0.1 1.4 1 0 0 1 1 1 1 Raf-like Ras-binding domain C1_1 PF00130.20 001165890.1_39524001_1 - 1.2e-10 41.0 10.2 2e-10 40.2 10.2 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.4 001165890.1_39524001_1 - 4.8e-08 32.5 0.0 7.3e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like zf-RING-like PF08746.9 001165890.1_39524001_1 - 0.0021 18.2 4.7 0.0056 16.8 4.7 1.7 1 0 0 1 1 1 1 RING-like domain APH PF01636.21 001165890.1_39524001_1 - 0.0071 16.2 0.5 0.14 11.9 0.1 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family TUG-UBL1 PF11470.6 001165890.1_39524001_1 - 0.038 14.1 0.1 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 TUG ubiquitin-like domain Kdo PF06293.12 001165890.1_39524001_1 - 0.087 12.0 0.2 0.16 11.2 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_2 PF13639.4 001165890.1_39524001_1 - 5.6 7.2 8.6 14 5.9 8.6 1.7 1 0 0 1 1 1 0 Ring finger domain Filament PF00038.19 001199067.1_39524001_2 - 7.1e-108 360.7 36.2 8.2e-108 360.5 36.2 1.0 1 0 0 1 1 1 1 Intermediate filament protein NYD-SP28_assoc PF14775.4 001199067.1_39524001_2 - 0.63 10.0 7.0 2.4 8.2 1.3 3.3 2 0 0 2 2 2 0 Sperm tail C-terminal domain DUF1664 PF07889.10 001199067.1_39524001_2 - 1.4 8.8 17.9 1.9 8.4 0.6 3.6 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Uso1_p115_C PF04871.11 001199067.1_39524001_2 - 3 8.1 22.2 0.36 11.1 4.3 3.1 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region TPR_MLP1_2 PF07926.10 001199067.1_39524001_2 - 4 7.4 36.2 0.29 11.0 3.3 4.3 3 2 1 4 4 4 0 TPR/MLP1/MLP2-like protein DUF724 PF05266.12 001199067.1_39524001_2 - 4.3 7.0 15.1 4.7 6.9 0.8 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF724) ERM PF00769.17 001199067.1_39524001_2 - 9.9 5.8 23.6 0.9 9.2 16.2 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family An_peroxidase PF03098.13 001190392.1_39529001_1 - 1.8e-134 449.1 0.0 2.4e-134 448.7 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase NAD_binding_6 PF08030.10 001190392.1_39529001_1 - 1.7e-30 106.1 0.0 2.7e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.17 001190392.1_39529001_1 - 7.8e-20 71.1 16.3 1.6e-19 70.2 16.3 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.10 001190392.1_39529001_1 - 1.9e-17 63.2 0.0 4.5e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain EF-hand_1 PF00036.30 001190392.1_39529001_1 - 1.4e-10 39.8 11.3 6.6e-06 25.2 1.2 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.4 001190392.1_39529001_1 - 1.4e-09 38.1 7.1 1.8e-05 25.0 2.5 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 001190392.1_39529001_1 - 1e-08 34.7 11.2 0.0015 18.1 0.3 3.8 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.4 001190392.1_39529001_1 - 4.2e-08 32.4 6.8 0.00034 20.2 0.4 3.3 3 0 0 3 3 3 2 EF-hand domain NAD_binding_1 PF00175.19 001190392.1_39529001_1 - 0.0053 17.2 0.0 0.15 12.6 0.0 2.5 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain PepSY_TM PF03929.14 001190392.1_39529001_1 - 0.0083 15.4 2.8 0.0089 15.3 0.0 2.2 2 0 0 2 2 1 1 PepSY-associated TM region EF-hand_5 PF13202.4 001190392.1_39529001_1 - 0.05 13.0 0.2 0.05 13.0 0.2 2.9 3 0 0 3 3 3 0 EF hand SIX1_SD PF16878.3 001161858.1_39522001_1 - 7.7e-48 161.5 0.2 8.1e-47 158.2 0.0 2.1 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeobox PF00046.27 001161858.1_39522001_1 - 1e-12 47.5 3.4 1.7e-12 46.9 1.0 2.2 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.9 001161858.1_39522001_1 - 8.7e-11 41.4 0.8 2.2e-10 40.1 0.8 1.7 1 0 0 1 1 1 1 Homeobox KN domain HTH_3 PF01381.20 001161858.1_39522001_1 - 0.023 14.6 0.0 0.05 13.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix FAM199X PF15814.3 001161858.1_39522001_1 - 0.042 12.8 1.2 0.054 12.4 1.2 1.1 1 0 0 1 1 1 0 Protein family FAM199X Homez PF11569.6 001161858.1_39522001_1 - 0.058 12.7 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Forkhead PF00250.16 001144947.1_39523001_1 - 1.1e-26 92.8 0.2 1.8e-26 92.1 0.2 1.3 1 0 0 1 1 1 1 Forkhead domain FOXP-CC PF16159.3 001144947.1_39523001_1 - 1.8e-26 92.4 2.4 1.8e-26 92.4 2.4 2.2 3 0 0 3 3 3 1 FOXP coiled-coil domain Sporozoite_P67 PF05642.9 001144947.1_39523001_2 - 4 5.3 5.7 4.8 5.0 5.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen IDO PF01231.16 001141953.1_39523001_1 - 6e-121 404.1 0.0 7.3e-121 403.8 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF1864 PF08933.9 001141953.1_39523001_1 - 0.026 13.2 0.1 0.26 9.9 0.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1864) Mannosyl_trans4 PF15971.3 001141953.1_39523001_1 - 0.093 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 DolP-mannose mannosyltransferase Ras PF00071.20 001161860.1_39522001_1 - 5.1e-67 224.4 0.5 6.1e-67 224.1 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001161860.1_39522001_1 - 6.6e-34 116.6 0.1 1.1e-33 115.8 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001161860.1_39522001_1 - 1.2e-16 60.5 0.3 1.5e-16 60.2 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001161860.1_39522001_1 - 6.8e-06 25.5 0.1 8.5e-06 25.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001161860.1_39522001_1 - 0.00033 20.0 0.1 0.0004 19.7 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 001161860.1_39522001_1 - 0.0024 17.8 0.0 0.0036 17.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001161860.1_39522001_1 - 0.0026 17.2 0.1 0.0048 16.3 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001161860.1_39522001_1 - 0.0031 17.3 0.2 1.6 8.5 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Septin PF00735.16 001161860.1_39522001_1 - 0.015 14.4 0.6 0.42 9.7 0.0 2.3 2 0 0 2 2 2 0 Septin DUF3963 PF13124.4 001161860.1_39522001_1 - 0.024 14.5 0.8 0.05 13.5 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3963) AAA_16 PF13191.4 001161860.1_39522001_1 - 0.12 12.6 0.0 0.18 12.0 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain Ras PF00071.20 001161861.1_39523001_3 - 1.3e-64 216.6 0.2 1.6e-64 216.2 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001161861.1_39523001_3 - 9.5e-34 116.1 0.2 1.4e-33 115.5 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001161861.1_39523001_3 - 1.7e-14 53.5 0.1 2.5e-14 53.0 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001161861.1_39523001_3 - 5.2e-05 22.7 0.0 7.7e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001161861.1_39523001_3 - 5.7e-05 22.4 0.1 7.4e-05 22.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001161861.1_39523001_3 - 0.0056 16.0 0.0 0.0081 15.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 001161861.1_39523001_3 - 0.014 15.4 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase Ras PF00071.20 001161862.1_39522001_1 - 1.9e-67 225.8 1.1 2.2e-67 225.5 1.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001161862.1_39522001_1 - 2.2e-37 127.8 0.1 3.9e-37 127.0 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001161862.1_39522001_1 - 1.2e-17 63.8 0.1 1.4e-17 63.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 001161862.1_39522001_1 - 7e-07 29.2 0.6 0.011 15.5 0.1 2.4 1 1 1 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001161862.1_39522001_1 - 7.1e-06 25.6 0.4 1.9e-05 24.2 0.4 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001161862.1_39522001_1 - 7.3e-06 25.4 0.1 9.8e-06 25.0 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001161862.1_39522001_1 - 9.7e-06 25.5 0.1 3e-05 24.0 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.8 001161862.1_39522001_1 - 1.4e-05 24.5 0.1 2.2e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.27 001161862.1_39522001_1 - 0.00094 19.5 0.0 0.12 12.6 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.16 001161862.1_39522001_1 - 0.0034 16.8 0.0 0.017 14.5 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.4 001161862.1_39522001_1 - 0.012 15.8 0.0 0.015 15.5 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.7 001161862.1_39522001_1 - 0.02 14.5 0.1 0.8 9.3 0.0 2.3 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.4 001161862.1_39522001_1 - 0.043 14.0 0.0 0.083 13.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.4 001161862.1_39522001_1 - 0.055 13.1 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.25 001161862.1_39522001_1 - 0.059 13.8 0.1 0.1 12.9 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_5 PF07728.12 001161862.1_39522001_1 - 0.064 13.1 0.0 0.087 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) LANC_like PF05147.11 001161862.1_39522001_1 - 0.071 11.5 0.1 0.15 10.5 0.0 1.5 1 1 0 1 1 1 0 Lanthionine synthetase C-like protein Asp PF00026.21 001009356.1_39523001_3 - 5.2e-86 288.8 0.0 8.1e-78 261.9 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.4 001009356.1_39523001_3 - 3.8e-14 53.2 0.6 3.4e-08 33.8 0.1 2.3 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001009356.1_39523001_3 - 3.5e-09 36.2 1.4 7.7e-09 35.1 1.4 1.6 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.4 001009356.1_39523001_3 - 1.8e-05 25.2 0.1 0.038 14.5 0.0 3.4 2 2 1 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.4 001009356.1_39523001_3 - 0.11 12.9 0.0 9.4 6.7 0.0 2.9 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease Ras PF00071.20 001161863.1_39522001_1 - 6e-59 198.1 0.2 7e-59 197.9 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001161863.1_39522001_1 - 9.6e-33 112.8 0.1 1.3e-32 112.4 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001161863.1_39522001_1 - 3.5e-14 52.5 0.1 4.7e-14 52.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001161863.1_39522001_1 - 1.2e-05 24.8 0.1 0.00063 19.2 0.1 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001161863.1_39522001_1 - 0.00015 21.7 0.0 0.00023 21.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.8 001161863.1_39522001_1 - 0.0011 18.3 0.0 0.0019 17.6 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.10 001161863.1_39522001_1 - 0.0013 18.0 0.0 0.0017 17.6 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.14 001161863.1_39522001_1 - 0.0022 17.8 0.0 0.89 9.3 0.1 2.3 2 1 0 2 2 2 2 Protein of unknown function, DUF258 PduV-EutP PF10662.7 001161863.1_39522001_1 - 0.013 15.1 0.1 0.037 13.6 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.15 001161863.1_39522001_1 - 0.033 13.8 0.0 4.7 6.8 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.4 001161863.1_39522001_1 - 0.035 14.3 0.1 0.21 11.8 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.4 001161863.1_39522001_1 - 0.043 14.1 0.1 0.068 13.4 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain ATPase_2 PF01637.16 001161863.1_39522001_1 - 0.061 13.1 0.0 0.096 12.5 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Septin PF00735.16 001161863.1_39522001_1 - 0.065 12.3 0.0 0.093 11.8 0.0 1.2 1 0 0 1 1 1 0 Septin ATPase PF06745.11 001161863.1_39522001_1 - 0.072 12.3 0.1 0.14 11.3 0.1 1.4 1 0 0 1 1 1 0 KaiC DUF2075 PF09848.7 001161863.1_39522001_1 - 0.084 12.0 0.1 0.19 10.8 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.10 001161863.1_39522001_1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain TNF PF00229.16 001075101.1_39522001_1 - 5.1e-30 103.9 0.2 1.3e-29 102.6 0.1 1.7 2 0 0 2 2 2 1 TNF(Tumour Necrosis Factor) family DUF3432 PF11914.6 001142506.1_39524001_1 - 4.4e-33 113.3 61.2 1.3e-29 102.2 38.7 5.9 4 2 2 6 6 5 2 Domain of unknown function (DUF3432) DUF3446 PF11928.6 001142506.1_39524001_1 - 2.7e-26 91.5 14.7 2.7e-26 91.5 14.7 5.4 5 1 1 6 6 3 1 Domain of unknown function (DUF3446) zf-H2C2_2 PF13465.4 001142506.1_39524001_1 - 7.9e-16 57.6 19.7 1e-07 32.0 0.7 4.2 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.24 001142506.1_39524001_1 - 9.7e-15 54.0 16.5 4.2e-05 23.6 0.3 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001142506.1_39524001_1 - 4e-11 42.6 12.9 0.0027 18.2 2.1 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001142506.1_39524001_1 - 0.0012 19.0 1.8 16 5.8 0.0 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001142506.1_39524001_1 - 0.0016 18.2 3.4 2.8 7.9 0.3 3.5 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2HC_2 PF13913.4 001142506.1_39524001_1 - 0.0041 16.8 8.8 0.26 11.1 0.4 3.3 3 0 0 3 3 3 1 zinc-finger of a C2HC-type zf-BED PF02892.13 001142506.1_39524001_1 - 0.01 15.8 7.9 0.013 15.4 3.1 2.6 1 1 1 2 2 2 0 BED zinc finger Cornifin PF02389.13 001142506.1_39524001_1 - 0.011 15.8 6.9 0.011 15.8 6.9 2.7 3 1 0 3 3 2 0 Cornifin (SPRR) family Zf_RING PF16744.3 001142506.1_39524001_1 - 0.011 15.7 1.8 0.33 11.0 0.1 2.3 1 1 1 2 2 2 0 KIAA1045 RING finger zf-met PF12874.5 001142506.1_39524001_1 - 0.014 15.6 8.6 2.9 8.2 1.3 3.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.3 001142506.1_39524001_1 - 0.057 13.6 4.9 0.24 11.6 1.7 2.7 1 1 2 3 3 3 0 C2H2-type zinc ribbon zf-C2H2_11 PF16622.3 001142506.1_39524001_1 - 0.61 9.8 6.9 31 4.3 0.1 3.5 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-CHY PF05495.10 001142506.1_39524001_1 - 1.1 9.7 4.0 1.7 9.1 2.4 1.9 1 1 1 2 2 2 0 CHY zinc finger Spexin PF15171.4 001287469.1_39522001_1 - 3.5e-49 164.8 3.4 4.6e-49 164.4 3.4 1.1 1 0 0 1 1 1 1 Neuropeptide secretory protein family, NPQ, spexin GDI PF00996.16 001161865.1_39523001_1 - 3.9e-236 783.4 0.1 4.6e-236 783.2 0.1 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor DUF2312 PF10073.7 001161865.1_39523001_1 - 0.13 11.8 0.2 0.3 10.6 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) 7tm_1 PF00001.19 001308583.1_39523001_1 - 7.8e-57 192.4 17.8 7.8e-57 192.4 17.8 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001308583.1_39523001_1 - 5.3e-10 39.0 20.0 7.9e-09 35.1 20.0 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001308583.1_39523001_1 - 0.00036 20.2 15.9 0.00096 18.8 15.9 1.7 1 1 0 1 1 1 1 Olfactory receptor Sel_put PF04328.11 001308583.1_39523001_3 - 0.039 13.9 0.0 0.07 13.0 0.0 1.4 1 0 0 1 1 1 0 Selenoprotein, putative SLAM PF06214.9 001040288.2_39523001_1 - 5.2e-60 200.8 0.4 8.6e-60 200.1 0.4 1.4 1 0 0 1 1 1 1 Signaling lymphocytic activation molecule (SLAM) protein Ig_3 PF13927.4 001040288.2_39523001_1 - 1.1e-05 25.8 0.2 0.0019 18.6 0.2 2.7 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.15 001040288.2_39523001_1 - 0.0013 18.8 0.1 0.0042 17.1 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin V-set domain Receptor_2B4 PF11465.6 001040288.2_39523001_1 - 0.045 13.8 0.0 0.083 13.0 0.0 1.5 1 0 0 1 1 1 0 Natural killer cell receptor 2B4 ig PF00047.23 001040288.2_39523001_1 - 0.058 13.4 0.1 0.6 10.2 0.1 2.4 2 0 0 2 2 2 0 Immunoglobulin domain Lectin_C PF00059.19 001038014.1_39522001_2 - 5.6e-18 65.5 0.0 7.4e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 Lectin C-type domain Tyrosinase PF00264.18 001130027.1_39524001_2 - 2.4e-43 148.9 0.3 3.2e-43 148.5 0.3 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase Laminin_EGF PF00053.22 001130027.1_39524001_2 - 0.019 15.0 2.4 0.019 15.0 2.4 2.8 3 0 0 3 3 3 0 Laminin EGF domain GDI PF00996.16 001161871.1_39523001_1 - 1.8e-242 804.3 0.1 2.1e-242 804.1 0.1 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Amino_oxidase PF01593.22 001161871.1_39523001_1 - 0.012 14.7 0.0 0.017 14.3 0.0 1.1 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Ras PF00071.20 001161876.1_39523001_2 - 1.9e-49 167.3 0.0 2.3e-49 167.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001161876.1_39523001_2 - 2e-30 105.4 0.0 3.3e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001161876.1_39523001_2 - 3.4e-11 42.8 0.0 4.7e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001161876.1_39523001_2 - 0.0003 20.7 0.0 0.00046 20.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.20 001161876.1_39523001_2 - 0.00084 19.6 0.1 0.0026 18.0 0.1 1.8 1 1 0 1 1 1 1 RNA helicase GTP_EFTU PF00009.25 001161876.1_39523001_2 - 0.0027 17.1 0.3 0.012 15.1 0.3 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001161876.1_39523001_2 - 0.0035 16.6 0.0 0.0047 16.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Pox_A32 PF04665.10 001161876.1_39523001_2 - 0.025 13.9 0.1 0.043 13.1 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein SRPRB PF09439.8 001161876.1_39523001_2 - 0.026 13.8 0.0 0.04 13.2 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.4 001161876.1_39523001_2 - 0.027 14.1 0.0 0.04 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.18 001161876.1_39523001_2 - 0.032 13.3 1.6 1.3 8.0 0.1 2.8 2 1 1 3 3 3 0 G-protein alpha subunit ArgoMid PF16487.3 001161876.1_39523001_2 - 0.058 13.5 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 Mid domain of argonaute TsaE PF02367.15 001161876.1_39523001_2 - 0.087 12.7 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.4 001161876.1_39523001_2 - 0.1 12.8 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain DUF4723 PF15851.3 001174112.1_39521001_2 - 0.036 14.0 7.4 0.05 13.6 7.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4723) Activin_recp PF01064.21 001174112.1_39521001_2 - 1.4 9.9 10.7 5.6 8.0 10.7 1.9 1 1 0 1 1 1 0 Activin types I and II receptor domain SIX1_SD PF16878.3 001174113.1_39522001_1 - 3.2e-49 165.9 0.1 6.3e-49 165.0 0.1 1.5 1 0 0 1 1 1 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeobox PF00046.27 001174113.1_39522001_1 - 1.6e-14 53.3 1.3 3.7e-14 52.2 0.2 2.1 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.9 001174113.1_39522001_1 - 6.5e-13 48.2 1.1 1.4e-12 47.2 1.1 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.6 001174113.1_39522001_1 - 0.0039 16.5 0.1 0.014 14.7 0.1 1.9 2 0 0 2 2 2 1 Homeodomain leucine-zipper encoding, Homez HTH_3 PF01381.20 001174113.1_39522001_1 - 0.008 16.1 0.0 0.027 14.4 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix YdaS_antitoxin PF15943.3 001174113.1_39522001_1 - 0.076 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Phage_mat-A PF03863.11 001174113.1_39522001_1 - 0.13 11.0 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Phage maturation protein KilA-N PF04383.11 001174113.1_39522001_1 - 0.19 11.4 1.6 0.96 9.2 0.6 2.0 2 0 0 2 2 2 0 KilA-N domain MHC_II_alpha PF00993.18 001123398.2_39523001_3 - 6e-35 118.7 0.0 8.8e-35 118.1 0.0 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001123398.2_39523001_3 - 2.2e-25 87.7 0.3 4.4e-25 86.7 0.3 1.5 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001123398.2_39523001_3 - 1.5e-21 76.5 0.0 2.5e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Marek_A PF02124.13 001123398.2_39523001_3 - 0.0017 18.1 0.0 0.0026 17.5 0.0 1.2 1 0 0 1 1 1 1 Marek's disease glycoprotein A Ig_3 PF13927.4 001123398.2_39523001_3 - 0.0022 18.5 0.0 0.0036 17.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain SKG6 PF08693.8 001123398.2_39523001_3 - 0.021 14.1 0.2 0.021 14.1 0.2 1.8 2 0 0 2 2 2 0 Transmembrane alpha-helix domain LRR_9 PF14580.4 001282137.1_39522001_1 - 8.1e-14 51.4 0.0 5.8e-13 48.6 0.0 1.9 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.5 001282137.1_39522001_1 - 7.8e-09 35.5 7.5 8e-05 22.8 0.2 3.9 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001282137.1_39522001_1 - 4.9e-08 32.5 1.5 4.9e-08 32.5 1.5 2.4 2 0 0 2 2 2 1 Leucine rich repeat LRR_1 PF00560.31 001282137.1_39522001_1 - 0.41 11.2 6.3 80 4.2 0.0 4.3 4 0 0 4 4 4 0 Leucine Rich Repeat Ras PF00071.20 001127283.1_39522001_1 - 8.3e-39 132.7 0.0 1.1e-38 132.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001127283.1_39522001_1 - 1.7e-26 92.7 0.1 2.7e-26 92.0 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001127283.1_39522001_1 - 2.7e-12 46.3 0.0 3.6e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001127283.1_39522001_1 - 1.2e-05 24.6 0.0 1.5e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.7 001127283.1_39522001_1 - 0.041 13.5 0.1 0.1 12.2 0.1 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DLIC PF05783.9 001127283.1_39522001_1 - 0.065 11.9 0.2 0.34 9.6 0.1 1.9 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) G-alpha PF00503.18 001127283.1_39522001_1 - 0.14 11.2 0.4 0.52 9.3 0.2 2.0 1 1 1 2 2 2 0 G-protein alpha subunit Calsarcin PF05556.9 001199795.1_39522001_1 - 1.5e-34 119.5 0.0 3.2e-34 118.4 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) Ras PF00071.20 001161881.1_39522001_1 - 6.8e-63 211.0 0.3 7.8e-63 210.8 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001161881.1_39522001_1 - 2.5e-35 121.1 0.1 5.8e-35 120.0 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001161881.1_39522001_1 - 1.2e-12 47.5 0.0 1.5e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001161881.1_39522001_1 - 3.1e-05 23.3 0.1 4.2e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001161881.1_39522001_1 - 6.5e-05 22.9 0.0 0.0001 22.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001161881.1_39522001_1 - 0.0005 19.9 0.3 0.33 10.7 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001161881.1_39522001_1 - 0.0025 17.3 0.0 0.0056 16.1 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.4 001161881.1_39522001_1 - 0.012 15.9 0.1 0.024 14.9 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain MCR_beta PF02241.16 001161881.1_39522001_1 - 0.07 12.6 0.2 0.091 12.2 0.2 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain BrnT_toxin PF04365.11 001161881.1_39522001_1 - 0.07 13.3 0.1 0.54 10.5 0.0 2.0 2 0 0 2 2 2 0 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system ADK PF00406.20 001161882.1_39522001_1 - 2.5e-53 180.1 0.1 3e-53 179.8 0.1 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.4 001161882.1_39522001_1 - 3.5e-40 137.4 0.2 4.5e-40 137.1 0.2 1.1 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 001161882.1_39522001_1 - 1.5e-08 34.8 0.0 3.6e-08 33.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.4 001161882.1_39522001_1 - 1.1e-07 32.3 0.0 1.6e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.15 001161882.1_39522001_1 - 1.1e-05 25.1 0.2 0.09 12.3 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase Cytidylate_kin PF02224.16 001161882.1_39522001_1 - 0.0043 16.7 0.0 0.024 14.2 0.0 2.0 2 0 0 2 2 2 1 Cytidylate kinase Zeta_toxin PF06414.10 001161882.1_39522001_1 - 0.0045 16.2 0.2 0.011 14.9 0.2 1.9 1 1 0 1 1 1 1 Zeta toxin dNK PF01712.17 001161882.1_39522001_1 - 0.0057 16.4 0.2 0.019 14.7 0.0 1.9 2 0 0 2 2 2 1 Deoxynucleoside kinase AAA_22 PF13401.4 001161882.1_39522001_1 - 0.02 15.0 0.2 0.062 13.4 0.1 1.8 1 1 1 2 2 2 0 AAA domain AAA_19 PF13245.4 001161882.1_39522001_1 - 0.03 14.5 0.4 0.038 14.2 0.3 1.4 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.20 001161882.1_39522001_1 - 0.069 12.0 0.5 0.094 11.6 0.1 1.4 2 0 0 2 2 2 0 NB-ARC domain AAA PF00004.27 001161882.1_39522001_1 - 0.12 12.7 0.1 1 9.6 0.1 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PPTA PF01239.20 001161883.1_39522001_1 - 1.4e-48 161.2 17.6 1.1e-11 43.9 0.3 6.0 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat TPR_14 PF13428.4 001161883.1_39522001_1 - 0.026 15.2 1.7 2.2 9.2 0.2 4.0 4 1 1 5 5 5 0 Tetratricopeptide repeat Retrotran_gag_3 PF14244.4 001161883.1_39522001_1 - 0.22 11.2 0.7 26 4.6 0.1 3.3 3 1 0 3 3 3 0 gag-polypeptide of LTR copia-type Darcynin PF17074.3 001161883.1_39522001_1 - 0.27 11.3 2.8 1.4 9.0 2.3 2.1 1 1 1 2 2 2 0 Darcynin, domain of unknown function Cyclin_N PF00134.21 001127289.1_39522001_1 - 6.6e-36 122.8 0.8 8.9e-36 122.4 0.8 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001127289.1_39522001_1 - 3.4e-18 65.7 0.0 2.1e-17 63.2 0.0 2.1 2 0 0 2 2 2 1 Cyclin, C-terminal domain K-cyclin_vir_C PF09080.8 001127289.1_39522001_1 - 0.02 15.2 0.1 0.032 14.5 0.1 1.3 1 0 0 1 1 1 0 K cyclin, C terminal Pkinase PF00069.23 001161884.1_39523001_1 - 6e-34 117.5 0.0 8e-34 117.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001161884.1_39523001_1 - 5.5e-24 84.7 0.0 1e-21 77.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Cyclin_N PF00134.21 001127290.1_39522001_1 - 2.6e-37 127.3 0.4 4.2e-37 126.6 0.4 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001127290.1_39522001_1 - 4.6e-19 68.5 0.0 2e-18 66.4 0.0 2.0 2 0 0 2 2 2 1 Cyclin, C-terminal domain K-cyclin_vir_C PF09080.8 001127290.1_39522001_1 - 0.00052 20.3 0.1 0.00083 19.6 0.1 1.3 1 0 0 1 1 1 1 K cyclin, C terminal Filament PF00038.19 001308600.1_39524001_3 - 1.1e-119 399.5 27.3 1.3e-119 399.3 27.3 1.1 1 0 0 1 1 1 1 Intermediate filament protein FlxA PF14282.4 001308600.1_39524001_3 - 0.074 12.9 15.0 4.5 7.2 11.6 2.8 2 0 0 2 2 2 0 FlxA-like protein DUF1664 PF07889.10 001308600.1_39524001_3 - 0.27 11.1 17.1 0.87 9.5 1.3 4.2 4 1 0 4 4 4 0 Protein of unknown function (DUF1664) Bacillus_HBL PF05791.9 001308600.1_39524001_3 - 0.37 10.4 8.6 0.18 11.4 2.8 3.0 1 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) RasGAP_C PF03836.13 001308600.1_39524001_3 - 0.41 10.7 21.6 0.2 11.7 0.7 3.5 2 1 2 4 4 4 0 RasGAP C-terminus Ribonuclease_T2 PF00445.16 001308600.1_39524001_3 - 0.43 10.6 4.1 0.72 9.8 2.2 2.2 2 1 0 2 2 2 0 Ribonuclease T2 family Lectin_N PF03954.12 001308600.1_39524001_3 - 0.51 10.0 6.1 6.8 6.3 0.0 2.7 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain DUF4510 PF14971.4 001308600.1_39524001_3 - 0.86 9.8 6.7 0.31 11.2 2.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4510) Cob_adeno_trans PF01923.16 001308600.1_39524001_3 - 3.9 7.5 8.1 0.73 9.8 1.2 2.6 1 1 1 2 2 2 0 Cobalamin adenosyltransferase DUF4407 PF14362.4 001308600.1_39524001_3 - 4.4 6.4 19.9 1.7 7.8 8.3 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Reo_sigmaC PF04582.10 001308600.1_39524001_3 - 5.6 6.1 6.2 11 5.1 0.4 2.7 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Fib_alpha PF08702.8 001308600.1_39524001_3 - 6.2 6.9 18.9 0.57 10.2 1.4 4.1 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family ubiquitin PF00240.21 001161886.1_39524001_1 - 7.9e-19 67.0 1.5 1.4e-18 66.2 1.5 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.29 001161886.1_39524001_1 - 7.4e-08 32.0 0.6 2e-07 30.7 0.6 1.8 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.6 001161886.1_39524001_1 - 1.2e-06 28.1 0.5 2.2e-06 27.3 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.4 001161886.1_39524001_1 - 0.00064 19.7 0.5 0.0015 18.5 0.5 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.8 001161886.1_39524001_1 - 0.0012 19.3 0.0 0.0033 17.9 0.0 1.8 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD DUF2407 PF10302.7 001161886.1_39524001_1 - 0.008 16.6 0.1 0.031 14.7 0.1 2.0 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain HOIP-UBA PF16678.3 001161886.1_39524001_1 - 0.048 13.5 0.2 0.13 12.1 0.0 1.8 2 0 0 2 2 2 0 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase CUE PF02845.14 001161886.1_39524001_1 - 0.072 12.7 1.6 0.22 11.1 0.0 2.5 2 0 0 2 2 2 0 CUE domain Atg8 PF02991.14 001161886.1_39524001_1 - 0.14 12.3 0.0 0.32 11.1 0.0 1.5 1 0 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like Cys_knot PF00007.20 001164714.1_39523001_1 - 3.4e-17 62.5 10.6 3.4e-17 62.5 10.6 3.6 4 0 0 4 4 4 1 Cystine-knot domain VWC PF00093.16 001164714.1_39523001_1 - 4e-10 39.7 9.4 4e-10 39.7 9.4 5.0 3 2 0 3 3 3 1 von Willebrand factor type C domain IGFBP PF00219.16 001164714.1_39523001_1 - 1.4e-09 38.3 20.7 1.4e-09 38.3 20.7 5.6 3 2 3 6 6 6 1 Insulin-like growth factor binding protein TSP_1 PF00090.17 001164714.1_39523001_1 - 9e-06 25.7 6.2 9e-06 25.7 6.2 3.6 3 0 0 3 3 3 1 Thrombospondin type 1 domain tRNA-synt_2 PF00152.18 001161887.1_39524001_3 - 6e-80 268.5 0.1 9.1e-80 267.9 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.23 001161887.1_39524001_3 - 1.3e-08 34.6 1.5 2.9e-08 33.5 1.5 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.18 001161887.1_39524001_3 - 5.5e-05 22.6 0.2 0.29 10.5 0.1 2.5 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) S-AdoMet_synt_N PF00438.18 001161887.1_39524001_3 - 0.037 14.6 1.6 0.11 13.1 1.0 2.1 2 1 0 2 2 2 0 S-adenosylmethionine synthetase, N-terminal domain fn2 PF00040.17 001143665.2_39522001_1 - 8e-28 96.3 19.6 2e-15 56.6 3.5 2.3 2 0 0 2 2 2 2 Fibronectin type II domain Integrin_B_tail PF07965.10 001143665.2_39522001_1 - 0.33 11.3 3.3 11 6.5 0.3 2.2 1 1 1 2 2 2 0 Integrin beta tail domain Hepcidin PF06446.10 001195312.1_39521001_1 - 1.6e-17 63.5 10.7 2.1e-17 63.1 10.7 1.2 1 0 0 1 1 1 1 Hepcidin cEGF PF12662.5 001161888.1_39524001_1 - 4.2e-29 100.0 37.9 1.4e-08 34.4 3.1 6.7 6 0 0 6 6 6 5 Complement Clr-like EGF-like EGF_CA PF07645.13 001161888.1_39524001_1 - 2.9e-23 81.6 71.6 1.1e-10 41.3 10.0 5.9 4 1 1 5 5 4 3 Calcium-binding EGF domain FXa_inhibition PF14670.4 001161888.1_39524001_1 - 2.8e-22 78.6 73.5 2.1e-06 27.8 6.6 5.9 5 0 0 5 5 5 5 Coagulation Factor Xa inhibitory site Lectin_C PF00059.19 001161888.1_39524001_1 - 1e-09 39.0 0.1 1e-09 39.0 0.1 2.1 2 1 1 3 3 1 1 Lectin C-type domain EGF PF00008.25 001161888.1_39524001_1 - 1.8e-07 31.2 73.7 0.00046 20.3 10.3 6.4 6 1 0 6 6 6 4 EGF-like domain TMEM154 PF15102.4 001161888.1_39524001_1 - 9.4e-05 22.2 0.0 0.00017 21.4 0.0 1.3 1 0 0 1 1 1 1 TMEM154 protein family EGF_3 PF12947.5 001161888.1_39524001_1 - 0.0025 17.8 61.9 0.027 14.5 9.6 6.0 5 0 0 5 5 5 4 EGF domain TMEM51 PF15345.4 001161888.1_39524001_1 - 0.0082 15.9 0.0 0.02 14.6 0.0 1.5 2 0 0 2 2 2 1 Transmembrane protein 51 hEGF PF12661.5 001161888.1_39524001_1 - 0.015 15.8 7.8 0.015 15.8 7.8 8.9 9 2 0 9 9 6 0 Human growth factor-like EGF EphA2_TM PF14575.4 001161888.1_39524001_1 - 0.026 15.2 0.0 0.069 13.8 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SIT PF15330.4 001161888.1_39524001_1 - 0.038 14.3 0.0 0.1 12.8 0.0 1.7 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT stn_TNFRSF12A PF12191.6 001161888.1_39524001_1 - 0.055 13.6 0.0 0.23 11.5 0.0 2.1 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain CcmD PF04995.12 001161888.1_39524001_1 - 0.056 13.4 0.4 0.056 13.4 0.4 1.8 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) TRAP_alpha PF03896.14 001161888.1_39524001_1 - 0.068 12.2 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit IL13 PF03487.11 001082594.1_39523001_1 - 1.5e-63 212.3 0.4 2.2e-63 211.8 0.4 1.2 1 0 0 1 1 1 1 Interleukin-13 Rep_fac-A_C PF08646.8 001161889.1_39524001_1 - 5.7e-59 197.9 9.8 2.4e-55 186.2 6.8 2.4 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.3 001161889.1_39524001_1 - 1.3e-37 127.5 1.8 2.1e-35 120.4 0.8 2.5 2 0 0 2 2 2 2 Replication protein A OB domain Rep-A_N PF04057.10 001161889.1_39524001_1 - 1.8e-35 120.9 0.1 3.8e-35 119.8 0.1 1.6 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.23 001161889.1_39524001_1 - 1.5e-12 47.2 0.2 1.2e-11 44.2 0.0 2.4 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain IBR PF01485.19 001161889.1_39524001_1 - 0.025 14.7 3.1 0.095 12.8 3.3 1.8 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Lyase_1 PF00206.18 001161891.1_39524001_1 - 5.7e-124 413.4 0.1 7.5e-124 413.0 0.1 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.7 001161891.1_39524001_1 - 9.2e-27 93.1 0.5 3.7e-26 91.2 0.1 2.2 2 0 0 2 2 2 1 Fumarase C C-terminus ADH_N PF08240.10 001161891.1_39524001_1 - 0.13 12.0 0.0 0.34 10.7 0.0 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain YadA_anchor PF03895.13 001161891.1_39524001_1 - 0.24 11.6 2.5 0.42 10.8 0.2 2.4 2 0 0 2 2 2 0 YadA-like C-terminal region Pkinase_Tyr PF07714.15 001161892.1_39523001_1 - 6.1e-96 320.5 0.0 7.7e-96 320.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001161892.1_39523001_1 - 1.7e-48 165.2 0.0 2.3e-48 164.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001161892.1_39523001_1 - 7.7e-24 83.4 0.0 1.7e-23 82.3 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001161892.1_39523001_1 - 1.8e-17 62.5 0.1 3.9e-17 61.4 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001161892.1_39523001_1 - 6e-09 35.5 0.0 1.3e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001161892.1_39523001_1 - 2.1e-07 30.4 0.1 5.5e-07 29.1 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain MHC_II_alpha PF00993.18 001280717.1_39522001_1 - 1.5e-36 123.8 0.2 2.1e-36 123.4 0.2 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001280717.1_39522001_1 - 1e-26 91.9 0.2 2.8e-26 90.5 0.2 1.8 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001280717.1_39522001_1 - 1.4e-21 76.6 0.0 2.1e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001280717.1_39522001_1 - 5.6e-05 23.5 0.0 0.0001 22.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001280717.1_39522001_1 - 0.049 13.3 0.0 0.08 12.6 0.0 1.3 1 0 0 1 1 1 0 Marek's disease glycoprotein A Pkinase PF00069.23 001142507.1_39524001_3 - 1.3e-71 240.9 0.0 1.7e-71 240.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001142507.1_39524001_3 - 1.9e-43 148.5 0.0 2.7e-43 148.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001142507.1_39524001_3 - 1e-06 28.2 0.0 5e-06 25.9 0.0 1.9 2 0 0 2 2 2 1 Kinase-like MTBP_C PF14920.4 001142507.1_39524001_3 - 0.0059 16.2 2.3 0.012 15.2 2.3 1.4 1 0 0 1 1 1 1 MDM2-binding FTA2 PF13095.4 001142507.1_39524001_3 - 0.027 14.0 0.1 0.54 9.7 0.0 2.1 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.21 001142507.1_39524001_3 - 0.12 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.9 001142507.1_39524001_3 - 0.21 10.5 0.0 0.3 9.9 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Sec7 PF01369.18 001142512.1_39524001_3 - 1e-66 224.0 0.0 1.4e-66 223.6 0.0 1.1 1 0 0 1 1 1 1 Sec7 domain PH PF00169.27 001142512.1_39524001_3 - 4.6e-28 97.7 0.8 1e-27 96.6 0.0 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.4 001142512.1_39524001_3 - 1.4e-05 25.3 0.3 5.4e-05 23.4 0.3 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.4 001142512.1_39524001_3 - 0.012 15.5 0.1 0.057 13.4 0.1 2.0 1 1 0 1 1 1 0 PH domain PH_8 PF15409.4 001142512.1_39524001_3 - 0.023 14.8 0.0 0.18 12.0 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain NUDE_C PF04880.11 001142512.1_39524001_3 - 0.31 11.4 4.5 0.55 10.5 4.5 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Pkinase_Tyr PF07714.15 001142515.1_39525001_3 - 2e-94 315.6 0.0 2.6e-94 315.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001142515.1_39525001_3 - 5.9e-47 160.1 0.0 8.1e-47 159.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001142515.1_39525001_3 - 7.4e-24 83.5 0.0 1.5e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001142515.1_39525001_3 - 1.7e-12 46.6 0.1 4e-12 45.4 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001142515.1_39525001_3 - 2.8e-08 33.3 0.3 7.6e-08 32.0 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.15 001142515.1_39525001_3 - 7.7e-08 31.8 0.0 1.9e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Kdo PF06293.12 001142515.1_39525001_3 - 0.013 14.7 0.0 0.036 13.3 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family PGK PF00162.17 001142516.1_39524001_2 - 1.5e-149 497.9 0.2 1.8e-149 497.7 0.2 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase bZIP_1 PF00170.19 001142518.1_39523001_2 - 7.8e-16 57.8 12.7 1.3e-15 57.0 12.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001142518.1_39523001_2 - 1.2e-05 25.2 9.7 1.2e-05 25.2 9.7 2.2 2 0 0 2 2 2 1 Basic region leucine zipper IncA PF04156.12 001142518.1_39523001_2 - 0.0033 17.1 4.0 0.0051 16.5 4.0 1.2 1 0 0 1 1 1 1 IncA protein Fez1 PF06818.13 001142518.1_39523001_2 - 0.0081 16.5 5.9 0.012 15.9 5.9 1.1 1 0 0 1 1 1 1 Fez1 DUF3450 PF11932.6 001142518.1_39523001_2 - 0.0087 15.2 3.1 0.014 14.6 3.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) DUF4407 PF14362.4 001142518.1_39523001_2 - 0.094 11.9 2.5 0.13 11.4 2.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG6 PF04111.10 001142518.1_39523001_2 - 0.18 11.1 6.6 0.24 10.6 6.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 V_ATPase_I PF01496.17 001142518.1_39523001_2 - 0.37 8.5 1.1 0.48 8.1 1.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Laminin_II PF06009.10 001142518.1_39523001_2 - 0.46 10.4 5.9 0.7 9.8 5.9 1.3 1 0 0 1 1 1 0 Laminin Domain II AAA_13 PF13166.4 001142518.1_39523001_2 - 0.73 8.3 10.0 0.94 7.9 10.0 1.1 1 0 0 1 1 1 0 AAA domain BLOC1_2 PF10046.7 001142518.1_39523001_2 - 0.77 10.0 5.8 1.9 8.7 4.0 2.3 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_F PF12259.6 001142518.1_39523001_2 - 1.3 7.3 3.7 1.8 6.8 3.7 1.1 1 0 0 1 1 1 0 Baculovirus F protein XhlA PF10779.7 001142518.1_39523001_2 - 2.2 8.4 5.8 18 5.5 2.0 2.7 3 0 0 3 3 3 0 Haemolysin XhlA HemX PF04375.12 001142518.1_39523001_2 - 2.7 7.1 5.8 3.6 6.6 5.8 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase ZapB PF06005.10 001142518.1_39523001_2 - 4.4 7.7 13.1 0.33 11.3 6.3 2.1 1 1 1 2 2 2 0 Cell division protein ZapB GrpE PF01025.17 001142518.1_39523001_2 - 6.1 6.3 10.1 7.5 6.0 9.3 1.6 1 1 0 1 1 1 0 GrpE DUF724 PF05266.12 001142518.1_39523001_2 - 6.4 6.4 15.5 12 5.5 14.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DivIC PF04977.13 001142518.1_39523001_2 - 7.2 6.3 11.2 5.3 6.8 8.5 1.9 1 1 1 2 2 2 0 Septum formation initiator OmpH PF03938.12 001142518.1_39523001_2 - 7.2 6.5 13.0 11 5.9 13.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) BRICHOS PF04089.12 001134304.1_39522001_1 - 8.2e-21 73.8 0.1 1.3e-20 73.1 0.1 1.4 1 0 0 1 1 1 1 BRICHOS domain SpoVG PF04026.10 001134304.1_39522001_1 - 0.12 12.4 0.1 0.8 9.8 0.1 2.3 1 1 1 2 2 2 0 SpoVG DUF3652 PF12372.6 001142638.1_39529001_1 - 1.1e-21 76.3 0.7 5.2e-21 74.1 0.7 2.3 1 0 0 1 1 1 1 Huntingtin protein region HEAT PF02985.20 001142638.1_39529001_1 - 1.7e-10 40.0 9.4 0.021 14.9 0.0 7.8 7 0 0 7 7 7 2 HEAT repeat HEAT_EZ PF13513.4 001142638.1_39529001_1 - 3.6e-05 24.0 7.8 0.36 11.2 0.0 6.7 5 1 1 6 6 6 2 HEAT-like repeat HEAT_2 PF13646.4 001142638.1_39529001_1 - 0.00015 22.0 2.9 0.8 10.0 0.4 5.7 4 2 1 5 5 5 1 HEAT repeats Vac14_Fab1_bd PF12755.5 001142638.1_39529001_1 - 0.0031 17.9 0.8 2.6 8.6 0.0 3.7 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.5 001142638.1_39529001_1 - 0.13 12.1 0.4 18 5.1 0.1 3.8 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Arm PF00514.21 001142638.1_39529001_1 - 1.4 8.9 5.7 29 4.8 0.0 5.0 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat DUF737 PF05300.9 001142638.1_39529001_1 - 3.7 7.7 5.6 1.4 9.1 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF737) Mito_fiss_reg PF05308.9 001142638.1_39529001_1 - 4 7.3 12.7 18 5.2 12.7 2.1 1 0 0 1 1 1 0 Mitochondrial fission regulator Gal-bind_lectin PF00337.20 001173083.1_09922001_2 - 1.5e-29 102.1 0.0 1.8e-29 101.9 0.0 1.1 1 0 0 1 1 1 1 Galactoside-binding lectin Orn_Arg_deC_N PF02784.14 001291480.1_09929001_1 - 4.9e-58 196.4 0.1 6.4e-58 196.0 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001291480.1_09929001_1 - 7.5e-21 74.2 0.0 1.2e-20 73.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain GSHPx PF00255.17 001256319.1_09922001_1 - 3.7e-40 135.7 0.3 5e-40 135.3 0.3 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.19 001256319.1_09922001_1 - 0.0051 16.6 0.1 0.11 12.2 0.1 2.2 1 1 0 1 1 1 1 AhpC/TSA family Ion_trans PF00520.29 001278760.1_09926001_3 - 1.1e-57 194.9 62.1 2.2e-29 102.3 28.3 2.4 3 0 0 3 3 3 2 Ion transport protein Pilin_N PF07790.9 001278760.1_09926001_3 - 0.017 15.9 0.2 0.26 12.1 0.1 2.4 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal SapB_2 PF03489.15 001172848.1_09925001_3 - 1.7e-23 82.3 10.3 8.7e-10 38.4 0.1 4.0 4 0 0 4 4 4 3 Saposin-like type B, region 2 SapA PF02199.13 001172848.1_09925001_3 - 1.2e-12 47.6 3.4 1.2e-12 47.6 3.4 2.2 2 0 0 2 2 2 1 Saposin A-type domain SapB_1 PF05184.13 001172848.1_09925001_3 - 2.6e-07 30.4 6.1 6e-06 26.0 1.2 3.5 3 0 0 3 3 3 2 Saposin-like type B, region 1 MHC_I_3 PF16497.3 001173068.1_09923001_3 - 9.9e-79 263.3 0.0 1.3e-78 262.9 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001173068.1_09923001_3 - 2.3e-11 43.8 0.0 5e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001173068.1_09923001_3 - 0.031 14.8 0.1 0.11 12.9 0.1 2.0 1 1 1 2 2 2 0 Immunoglobulin domain MHC_I PF00129.16 001173068.1_09923001_3 - 0.085 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 Caps_synth PF05704.10 001173068.1_09923001_3 - 0.12 11.7 0.6 5.7 6.1 0.2 2.1 2 0 0 2 2 2 0 Capsular polysaccharide synthesis protein Orn_Arg_deC_N PF02784.14 001293708.2_09924001_2 - 5.3e-70 235.5 0.0 6.5e-70 235.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001293708.2_09924001_2 - 9.5e-20 70.6 0.0 1.5e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 001293708.2_09924001_2 - 3.9e-05 23.1 0.0 8.1e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel RNase_H PF00075.22 001286000.1_09923001_2 - 2.1e-45 154.3 0.0 3e-45 153.8 0.0 1.2 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.14 001286000.1_09923001_2 - 2.8e-19 69.0 1.2 5.5e-19 68.1 1.2 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.4 001286000.1_09923001_2 - 0.0043 16.6 0.0 0.012 15.2 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase-like Rnk_N PF14760.4 001286000.1_09923001_2 - 0.026 14.9 0.1 0.061 13.7 0.1 1.7 1 1 0 1 1 1 0 Rnk N-terminus Yeast_MT PF11403.6 001286000.1_09923001_3 - 3.1 8.3 7.5 0.18 12.3 1.5 2.0 2 0 0 2 2 2 0 Yeast metallothionein Globin PF00042.20 001172872.2_09923001_1 - 1e-13 51.6 0.0 1.5e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 Globin NDK PF00334.17 001172873.1_09922001_2 - 1.2e-52 177.3 0.0 1.6e-52 177.0 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase FBA PF04300.11 001173089.1_09923001_2 - 1.3e-72 243.2 0.0 1.8e-72 242.8 0.0 1.2 1 0 0 1 1 1 1 F-box associated region F-box PF00646.31 001173089.1_09923001_2 - 2.1e-08 33.7 0.1 3.7e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.5 001173089.1_09923001_2 - 1.9e-06 27.5 3.1 1.9e-06 27.5 3.1 1.8 2 0 0 2 2 2 1 F-box-like V-set PF07686.15 001172876.1_09923001_2 - 5.2e-16 58.6 0.0 7.7e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001172876.1_09923001_2 - 7.5e-07 29.5 0.0 1.7e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001172876.1_09923001_2 - 3.6e-06 26.8 0.0 9.1e-06 25.5 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 001172876.1_09923001_2 - 0.00019 21.4 0.5 0.0011 19.0 0.5 2.0 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001172876.1_09923001_2 - 0.02 15.1 0.7 0.13 12.5 0.7 2.2 1 1 0 1 1 1 0 Immunoglobulin domain V-set PF07686.15 001172877.1_09923001_1 - 3.2e-15 56.1 0.0 5.3e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001172877.1_09923001_1 - 2.3e-06 28.0 0.0 5.9e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001172877.1_09923001_1 - 2.2e-05 24.4 0.1 6.7e-05 22.9 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin domain PAS_3 PF08447.10 001173098.1_09925001_1 - 8.1e-23 80.4 0.0 2.3e-17 62.9 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 001173098.1_09925001_1 - 1.1e-22 80.0 0.0 1.5e-14 53.8 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 001173098.1_09925001_1 - 2.7e-22 78.9 0.6 6.8e-20 71.1 0.2 2.7 2 1 0 2 2 2 1 PAS domain HLH PF00010.24 001173098.1_09925001_1 - 4.3e-15 55.3 1.6 9e-15 54.3 1.1 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 001173098.1_09925001_1 - 1.5e-08 34.7 0.0 1.3e-05 25.2 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 001173098.1_09925001_1 - 0.0029 17.7 0.0 0.88 9.7 0.0 2.5 2 0 0 2 2 2 2 PAS fold PRAS PF15798.3 001173098.1_09925001_1 - 0.1 13.1 0.2 0.1 13.1 0.2 2.2 2 0 0 2 2 2 0 Proline-rich AKT1 substrate 1 Sushi PF00084.18 001172892.1_09924001_1 - 5e-18 65.3 3.6 1.4e-08 35.1 1.2 2.4 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) AAA_18 PF13238.4 001285782.1_09922001_1 - 2.8e-31 108.6 0.2 1.4e-30 106.3 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.4 001285782.1_09922001_1 - 2.1e-08 34.5 0.1 5.1e-08 33.3 0.0 1.7 2 1 0 2 2 1 1 AAA domain AAA_28 PF13521.4 001285782.1_09922001_1 - 6.5e-06 26.4 0.0 1.3e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.27 001285782.1_09922001_1 - 7e-05 23.1 0.3 0.00038 20.8 0.1 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SKI PF01202.20 001285782.1_09922001_1 - 0.00025 21.1 0.2 0.013 15.5 0.0 2.2 2 0 0 2 2 2 1 Shikimate kinase AAA_33 PF13671.4 001285782.1_09922001_1 - 0.0004 20.4 0.1 0.008 16.2 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 001285782.1_09922001_1 - 0.00069 19.9 0.3 0.0018 18.6 0.3 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 001285782.1_09922001_1 - 0.00073 19.7 0.0 0.012 15.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.16 001285782.1_09922001_1 - 0.0013 18.4 0.0 0.0021 17.7 0.0 1.4 1 0 0 1 1 1 1 Cytidylate kinase NTPase_1 PF03266.13 001285782.1_09922001_1 - 0.0023 17.8 0.0 0.0058 16.4 0.0 1.7 1 0 0 1 1 1 1 NTPase KTI12 PF08433.8 001285782.1_09922001_1 - 0.003 16.9 0.0 0.065 12.5 0.0 2.1 2 0 0 2 2 2 1 Chromatin associated protein KTI12 Cytidylate_kin2 PF13189.4 001285782.1_09922001_1 - 0.0045 17.0 0.0 0.0062 16.6 0.0 1.5 1 1 0 1 1 1 1 Cytidylate kinase-like family ADK PF00406.20 001285782.1_09922001_1 - 0.005 16.8 0.1 0.052 13.5 0.0 2.2 2 0 0 2 2 2 1 Adenylate kinase AAA_5 PF07728.12 001285782.1_09922001_1 - 0.012 15.5 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase PF06745.11 001285782.1_09922001_1 - 0.014 14.7 1.5 0.057 12.6 0.2 2.0 2 0 0 2 2 2 0 KaiC dNK PF01712.17 001285782.1_09922001_1 - 0.019 14.7 2.4 2.2 8.0 0.1 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_24 PF13479.4 001285782.1_09922001_1 - 0.022 14.3 0.3 0.05 13.2 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.4 001285782.1_09922001_1 - 0.032 14.1 0.0 0.092 12.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.10 001285782.1_09922001_1 - 0.043 12.9 0.1 0.072 12.2 0.1 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_3 PF07726.9 001285782.1_09922001_1 - 0.051 13.3 0.0 0.096 12.4 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.20 001285782.1_09922001_1 - 0.053 13.8 0.1 0.14 12.4 0.0 1.8 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.10 001285782.1_09922001_1 - 0.085 12.6 0.1 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 NACHT domain MMR_HSR1 PF01926.21 001285782.1_09922001_1 - 0.1 12.5 0.3 0.17 11.9 0.3 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase Viral_helicase1 PF01443.16 001285782.1_09922001_1 - 0.16 11.5 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Thymidylate_kin PF02223.15 001285782.1_09922001_1 - 0.19 11.2 0.9 3 7.4 0.1 2.1 2 0 0 2 2 2 0 Thymidylate kinase VWD PF00094.23 001278774.1_09929001_2 - 3.4e-125 414.0 13.8 2.1e-37 128.7 0.1 4.8 4 0 0 4 4 4 4 von Willebrand factor type D domain VWA PF00092.26 001278774.1_09929001_2 - 2e-82 275.6 0.3 1.8e-31 109.6 0.0 3.2 3 0 0 3 3 3 3 von Willebrand factor type A domain C8 PF08742.9 001278774.1_09929001_2 - 2e-55 185.0 59.2 9.9e-18 64.2 7.6 8.2 9 0 0 9 9 9 4 C8 domain VWA_N2 PF16164.3 001278774.1_09929001_2 - 6.1e-41 138.3 4.3 6.1e-41 138.3 4.3 9.2 8 1 1 9 9 9 1 VWA N-terminal TIL PF01826.15 001278774.1_09929001_2 - 4.2e-29 100.4 109.2 8.3e-12 45.0 18.7 20.3 18 4 2 20 20 20 5 Trypsin Inhibitor like cysteine rich domain VWC PF00093.16 001278774.1_09929001_2 - 6.9e-16 58.2 73.1 6.7e-09 35.8 13.2 21.3 14 5 5 20 20 20 5 von Willebrand factor type C domain VWA_3 PF13768.4 001278774.1_09929001_2 - 2.1e-06 27.6 0.1 0.035 13.9 0.0 3.4 3 0 0 3 3 3 2 von Willebrand factor type A domain Pacifastin_I PF05375.11 001278774.1_09929001_2 - 0.00037 20.0 23.0 0.0011 18.5 6.6 11.8 15 0 0 15 15 15 2 Pacifastin inhibitor (LCMII) MCR_beta_N PF02783.13 001278774.1_09929001_2 - 0.022 14.3 0.0 0.042 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, N-terminal domain WD40 PF00400.30 001173106.1_09926001_1 - 7.5e-42 140.4 32.7 1.3e-05 25.7 0.0 11.1 10 0 0 10 10 10 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001173106.1_09926001_1 - 1.1e-18 67.2 0.3 0.0064 16.6 0.0 7.4 3 3 5 9 9 9 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001173106.1_09926001_1 - 1.1e-09 38.3 0.1 0.15 11.8 0.0 4.6 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 001173106.1_09926001_1 - 7.4e-05 21.7 5.4 0.27 10.0 0.0 4.7 3 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.10 001173106.1_09926001_1 - 0.00062 19.5 0.5 15 5.5 0.0 5.1 5 1 0 5 5 5 2 WD40-like Beta Propeller Repeat PQQ PF01011.19 001173106.1_09926001_1 - 0.012 15.4 0.7 0.051 13.4 0.0 2.5 2 0 0 2 2 2 0 PQQ enzyme repeat IKI3 PF04762.10 001173106.1_09926001_1 - 0.027 12.4 0.0 0.59 7.9 0.0 2.5 2 1 1 3 3 3 0 IKI3 family Nbas_N PF15492.4 001173106.1_09926001_1 - 0.039 13.2 1.2 26 3.9 0.1 4.1 3 2 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal BBS2_Mid PF14783.4 001173106.1_09926001_1 - 0.1 12.5 0.0 1.9 8.4 0.0 3.0 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region LRR_8 PF13855.4 001173042.1_09924001_3 - 1.3e-39 133.6 17.7 5.1e-15 54.9 2.2 4.5 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 001173042.1_09924001_3 - 1.8e-18 66.1 24.7 0.0002 21.5 2.7 6.8 2 1 3 8 8 8 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001173042.1_09924001_3 - 7.9e-11 41.6 3.8 2.6e-05 23.7 1.2 3.1 1 1 2 3 3 3 3 Leucine-rich repeat LRR_5 PF13306.4 001173042.1_09924001_3 - 4.9e-10 39.3 0.2 0.0047 16.7 0.0 3.3 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRRNT PF01462.16 001173042.1_09924001_3 - 7.5e-10 38.1 5.3 7.5e-10 38.1 5.3 2.7 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.4 001173042.1_09924001_3 - 0.0053 16.6 17.8 0.37 10.8 0.0 6.7 7 0 0 7 7 7 2 Leucine Rich repeat LRR_1 PF00560.31 001173042.1_09924001_3 - 0.039 14.3 14.5 35 5.3 0.0 7.4 7 2 0 7 7 7 0 Leucine Rich Repeat Retrotrans_gag PF03732.15 001291008.1_09929001_1 - 1.2e-13 51.0 1.9 1.6e-13 50.6 0.0 2.1 2 0 0 2 2 2 1 Retrotransposon gag protein DUF4939 PF16297.3 001291008.1_09929001_1 - 1.5e-13 50.4 0.1 2.7e-13 49.6 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) zf-CCHC_5 PF14787.4 001291008.1_09929001_1 - 0.0018 17.8 0.2 0.0045 16.5 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger DDHD PF02862.15 001291008.1_09929001_1 - 0.065 13.2 6.6 0.11 12.5 6.6 1.2 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.15 001291008.1_09929001_1 - 0.069 11.8 9.2 0.1 11.2 9.2 1.1 1 0 0 1 1 1 0 Presenilin DUF1664 PF07889.10 001291008.1_09929001_1 - 0.15 12.0 1.3 0.31 10.9 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) zf-CCHC PF00098.21 001291008.1_09929001_1 - 0.15 12.1 2.2 0.35 10.9 2.2 1.7 1 0 0 1 1 1 0 Zinc knuckle CDC27 PF09507.8 001291008.1_09929001_1 - 0.19 10.9 17.0 0.3 10.3 17.0 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RRN3 PF05327.9 001291008.1_09929001_1 - 0.42 9.0 10.7 0.6 8.5 10.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SDA1 PF05285.10 001291008.1_09929001_1 - 0.46 9.8 21.7 0.68 9.2 21.7 1.1 1 0 0 1 1 1 0 SDA1 DUF4407 PF14362.4 001291008.1_09929001_1 - 5.3 6.2 12.1 8.2 5.5 12.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EIIBC-GUT_N PF03612.12 001291008.1_09929001_1 - 6.4 6.3 7.6 11 5.5 7.6 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Paf1 PF03985.11 001291008.1_09929001_1 - 6.4 5.5 29.6 9.3 5.0 29.6 1.2 1 0 0 1 1 1 0 Paf1 DUF913 PF06025.10 001291008.1_09929001_1 - 7.7 5.2 9.7 12 4.6 9.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Nop14 PF04147.10 001291008.1_09929001_1 - 8.6 4.3 28.6 12 3.8 28.6 1.1 1 0 0 1 1 1 0 Nop14-like family Asp_protease_2 PF13650.4 001291008.1_09929001_3 - 0.004 17.7 0.0 0.0069 16.9 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001291008.1_09929001_3 - 0.031 14.1 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001291008.1_09929001_3 - 0.19 12.2 0.0 0.31 11.5 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Peptidase_M28 PF04389.15 001251822.1_09929001_1 - 2.3e-12 46.9 0.0 3.4e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.20 001251822.1_09929001_1 - 4.3e-08 33.0 0.0 8.1e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 PA domain TFR_dimer PF04253.13 001251822.1_09929001_1 - 1.1e-05 25.4 0.6 2.4e-05 24.3 0.2 1.8 2 0 0 2 2 2 1 Transferrin receptor-like dimerisation domain Lipocalin PF00061.21 001205184.1_09922001_2 - 7.6e-22 77.9 0.3 9.8e-22 77.6 0.3 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family DUF4985 PF16373.3 001205184.1_09922001_2 - 0.05 14.0 0.2 0.09 13.1 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function Clusterin PF01093.15 001281793.1_09924001_1 - 4.4e-155 516.8 11.1 5.2e-155 516.6 11.1 1.0 1 0 0 1 1 1 1 Clusterin CREPT PF16566.3 001281793.1_09924001_1 - 0.15 12.1 10.6 2.5 8.1 3.8 2.4 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Cofac_haem_bdg PF04187.11 001281793.1_09924001_1 - 0.52 10.1 2.5 2.5 7.9 0.3 2.3 2 0 0 2 2 2 0 Haem-binding uptake, Tiki superfamily, ChaN Laminin_II PF06009.10 001281793.1_09924001_1 - 2.1 8.2 9.5 1.3 8.9 3.3 2.2 2 0 0 2 2 2 0 Laminin Domain II Nefa_Nip30_N PF10187.7 001281793.1_09924001_1 - 3.9 7.8 12.3 0.92 9.8 6.3 2.4 2 0 0 2 2 2 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 GST_N PF02798.18 001172834.1_09923001_3 - 3.5e-22 78.4 0.0 8.8e-22 77.1 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001172834.1_09923001_3 - 4.1e-18 65.3 0.0 8.1e-18 64.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 001172834.1_09923001_3 - 1.2e-16 60.6 0.0 2.4e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 001172834.1_09923001_3 - 3.9e-05 23.2 0.1 0.00011 21.8 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001172834.1_09923001_3 - 0.0051 17.0 0.0 0.014 15.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 001172834.1_09923001_3 - 0.02 14.7 0.0 0.062 13.1 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain 7tm_1 PF00001.19 001172835.1_09924001_3 - 2.3e-41 141.7 11.1 4.9e-41 140.6 11.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001172835.1_09924001_3 - 6e-06 25.6 3.1 9.4e-06 25.0 3.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.7 001172835.1_09924001_3 - 4.1e-05 23.0 4.1 5.5e-05 22.5 4.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001172835.1_09924001_3 - 0.0059 16.2 5.3 0.015 14.9 5.3 1.7 1 1 0 1 1 1 1 Olfactory receptor Trp_oprn_chp PF09534.8 001172835.1_09924001_3 - 3 7.5 10.0 0.27 10.9 0.8 2.5 2 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Filament PF00038.19 001173033.1_09924001_2 - 7.9e-104 347.4 25.1 9.9e-104 347.1 25.1 1.1 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 001173033.1_09924001_2 - 0.0016 18.4 2.3 0.0016 18.4 2.3 4.4 3 1 1 4 4 4 1 TPR/MLP1/MLP2-like protein DUF2944 PF11161.6 001173033.1_09924001_2 - 0.011 15.4 0.2 0.022 14.5 0.2 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2946) SPATA1_C PF15743.3 001173033.1_09924001_2 - 0.032 14.2 0.2 0.032 14.2 0.2 3.4 2 1 0 3 3 3 0 Spermatogenesis-associated C-terminus DUF1664 PF07889.10 001173033.1_09924001_2 - 0.083 12.7 7.6 1.7 8.5 2.0 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.10 001173033.1_09924001_2 - 0.17 11.8 9.3 25 4.8 4.7 4.0 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-C4H2 PF10146.7 001173033.1_09924001_2 - 0.24 11.5 19.2 0.09 12.9 6.8 2.9 2 1 1 3 3 3 0 Zinc finger-containing protein T3SS_basalb_I PF17001.3 001173033.1_09924001_2 - 0.26 11.8 0.1 0.26 11.8 0.1 3.7 3 1 1 4 4 3 0 Type III secretion basal body protein I, YscI, HrpB, PscI Jnk-SapK_ap_N PF09744.7 001173033.1_09924001_2 - 0.3 11.2 26.0 0.079 13.1 1.2 3.8 3 1 1 4 4 4 0 JNK_SAPK-associated protein-1 Myosin_tail_1 PF01576.17 001173033.1_09924001_2 - 0.46 8.1 30.5 0.0032 15.2 5.1 2.4 1 1 1 2 2 2 0 Myosin tail CALCOCO1 PF07888.9 001173033.1_09924001_2 - 0.49 8.8 22.3 1.3 7.4 15.3 2.4 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Prefoldin_2 PF01920.18 001173033.1_09924001_2 - 1.5 8.7 19.7 6.6 6.6 2.6 5.1 3 2 2 5 5 5 0 Prefoldin subunit COG2 PF06148.9 001173033.1_09924001_2 - 1.6 8.7 11.6 0.33 10.9 2.3 3.6 3 1 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 RasGAP_C PF03836.13 001173033.1_09924001_2 - 2 8.4 11.4 1.6 8.8 0.2 3.2 2 1 0 3 3 3 0 RasGAP C-terminus GAS PF13851.4 001173033.1_09924001_2 - 2.8 7.2 23.4 8.4 5.6 9.3 3.4 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Atg14 PF10186.7 001173033.1_09924001_2 - 2.8 6.8 19.9 0.83 8.5 1.5 3.1 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4446 PF14584.4 001173033.1_09924001_2 - 2.9 7.7 8.5 2.9 7.7 0.0 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) XhlA PF10779.7 001173033.1_09924001_2 - 3.3 7.8 6.3 1.2 9.2 0.5 2.8 3 0 0 3 3 2 0 Haemolysin XhlA DUF4407 PF14362.4 001173033.1_09924001_2 - 4.7 6.3 23.9 1.5 8.0 5.2 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) SlyX PF04102.10 001173033.1_09924001_2 - 5.8 7.5 26.9 0.72 10.4 0.4 5.0 5 1 1 6 6 5 0 SlyX DUF972 PF06156.11 001173033.1_09924001_2 - 8.7 6.9 20.6 1.1 9.7 0.3 4.7 2 2 3 5 5 5 0 Protein of unknown function (DUF972) Ion_trans PF00520.29 001278778.1_09925001_2 - 1.6e-49 168.3 53.2 5.9e-32 110.7 22.0 2.1 2 0 0 2 2 2 2 Ion transport protein PRIMA1 PF16101.3 001278778.1_09925001_2 - 0.27 11.1 0.5 2.3 8.2 0.1 2.6 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 PKD_channel PF08016.10 001278778.1_09925001_2 - 9 4.7 44.9 0.67 8.4 3.8 4.5 3 2 1 4 4 4 0 Polycystin cation channel GDA1_CD39 PF01150.15 001172711.1_09924001_2 - 6.5e-68 229.2 0.0 3e-67 227.0 0.0 1.9 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ig_J_chain PF15097.4 001278776.1_09921001_1 - 1.3e-72 241.8 7.4 1.5e-72 241.6 7.4 1.0 1 0 0 1 1 1 1 Immunoglobulin J chain RTP1_C1 PF10363.7 001278776.1_09921001_1 - 0.0068 16.4 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 7tm_2 PF00002.22 001173121.1_09923001_1 - 6.2e-85 284.3 15.7 1.3e-84 283.2 13.5 2.0 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001173121.1_09923001_1 - 7.9e-21 74.0 3.7 7.9e-21 74.0 3.7 1.7 2 0 0 2 2 2 1 Hormone receptor domain TCTP PF00838.15 001173082.1_09923001_2 - 5.5e-82 273.8 0.4 6.6e-82 273.6 0.4 1.1 1 0 0 1 1 1 1 Translationally controlled tumour protein Cathelicidins PF00666.15 001173059.2_09922001_2 - 1.8e-34 117.9 0.0 2.5e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 Cathelicidin Spp-24 PF07448.9 001173059.2_09922001_2 - 0.023 14.7 0.1 0.04 14.0 0.1 1.3 1 0 0 1 1 1 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain TadE PF07811.10 001173059.2_09922001_2 - 0.049 13.8 1.7 0.083 13.1 1.7 1.3 1 0 0 1 1 1 0 TadE-like protein Cystatin PF00031.19 001173059.2_09922001_2 - 0.059 13.5 0.4 0.14 12.3 0.4 1.6 1 1 0 1 1 1 0 Cystatin domain Glyco_hydro_59 PF02057.13 001173059.2_09922001_2 - 0.17 9.9 0.0 0.22 9.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 59 DUF2723 PF11028.6 132324.1_32929120_3 - 3.7e-18 65.9 0.7 6.3e-18 65.1 0.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2723) TLV_coat PF00429.17 130971.1_32929120_1 - 1.6e-107 360.4 12.1 2e-71 241.2 2.7 2.1 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) KRAB PF01352.25 130971.1_32929120_1 - 6.9e-21 73.5 0.1 1.3e-20 72.7 0.1 1.5 1 0 0 1 1 1 1 KRAB box TLV_coat PF00429.17 130971.1_32929120_3 - 2.4e-08 33.0 0.0 3.2e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) Cadherin PF00028.15 001024130.2_39725001_1 - 8.1e-84 276.1 0.0 9.6e-20 70.7 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001024130.2_39725001_1 - 1.8e-36 123.7 4.8 4.1e-34 116.1 0.3 4.0 5 0 0 5 5 5 2 Cadherin-like Cadherin_C_2 PF16492.3 001024130.2_39725001_1 - 1.9e-26 92.5 0.1 4.5e-26 91.3 0.1 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001024130.2_39725001_1 - 3.6e-10 39.7 1.5 0.014 15.2 0.0 4.8 4 0 0 4 4 4 4 Cadherin-like Cadherin PF00028.15 001013016.2_39727001_1 - 9.2e-79 259.9 0.0 2.5e-17 63.0 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001013016.2_39727001_1 - 2.7e-36 123.1 0.7 8.5e-33 111.9 0.5 3.3 4 0 0 4 4 4 2 Cadherin-like Cadherin_C_2 PF16492.3 001013016.2_39727001_1 - 9.7e-28 96.7 0.2 2.4e-27 95.4 0.2 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001013016.2_39727001_1 - 1.5e-05 24.8 4.0 0.07 13.0 0.0 4.8 4 1 1 5 5 5 2 Cadherin-like Cadherin PF00028.15 001013015.2_39729001_1 - 2.9e-72 239.0 0.0 7.1e-16 58.3 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001013015.2_39729001_1 - 8.4e-35 118.3 2.3 3.5e-33 113.1 0.0 3.2 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.3 001013015.2_39729001_1 - 1.2e-26 93.2 0.5 1.2e-26 93.2 0.5 2.2 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001013015.2_39729001_1 - 1.8e-07 31.0 0.3 0.26 11.2 0.0 4.6 4 0 0 4 4 4 3 Cadherin-like Cadherin PF00028.15 001024131.2_39726001_1 - 1.4e-76 252.9 0.0 1.2e-16 60.8 0.0 6.1 6 0 0 6 6 6 5 Cadherin domain Cadherin_2 PF08266.10 001024131.2_39726001_1 - 1.7e-38 130.2 0.0 3.4e-35 119.6 0.3 3.2 3 0 0 3 3 3 2 Cadherin-like Cadherin_C_2 PF16492.3 001024131.2_39726001_1 - 7.1e-29 100.3 0.4 1.8e-28 99.0 0.4 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001024131.2_39726001_1 - 1.1e-08 34.9 0.5 0.025 14.4 0.0 4.5 4 0 0 4 4 4 3 Cadherin-like Cadherin PF00028.15 001013409.2_39726001_1 - 6.7e-79 260.3 0.0 7.8e-18 64.6 0.0 6.3 6 0 0 6 6 6 5 Cadherin domain Cadherin_2 PF08266.10 001013409.2_39726001_1 - 3.2e-43 145.3 0.1 2.2e-35 120.2 0.0 4.4 5 0 0 5 5 5 2 Cadherin-like Cadherin_C_2 PF16492.3 001013409.2_39726001_1 - 4.9e-28 97.6 0.5 1e-27 96.5 0.5 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001013409.2_39726001_1 - 4.7e-06 26.5 2.9 0.02 14.8 0.0 4.3 4 0 0 4 4 4 2 Cadherin-like Cadherin PF00028.15 001024132.2_39726001_2 - 5.4e-81 267.0 0.0 5.2e-17 61.9 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001024132.2_39726001_2 - 1.6e-35 120.6 3.6 4.6e-34 116.0 0.3 3.8 5 0 0 5 5 5 1 Cadherin-like Cadherin_C_2 PF16492.3 001024132.2_39726001_2 - 9.1e-28 96.8 0.2 2e-27 95.6 0.2 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001024132.2_39726001_2 - 3.3e-09 36.6 1.3 0.0089 15.9 0.0 4.8 4 0 0 4 4 4 4 Cadherin-like MRAP PF15183.4 001071823.1_39722001_2 - 6.9e-50 166.8 0.5 1.1e-49 166.1 0.5 1.3 1 0 0 1 1 1 1 Melanocortin-2 receptor accessory protein family FixQ PF05545.9 001071823.1_39722001_2 - 0.067 13.0 0.7 0.13 12.1 0.7 1.4 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Cadherin PF00028.15 001013020.2_39728001_2 - 2.2e-78 258.6 0.0 3.4e-20 72.2 0.0 6.2 6 0 0 6 6 6 5 Cadherin domain Cadherin_2 PF08266.10 001013020.2_39728001_2 - 6.1e-37 125.2 0.0 1.5e-31 107.9 0.0 3.8 4 0 0 4 4 4 2 Cadherin-like Cadherin_C_2 PF16492.3 001013020.2_39728001_2 - 2.5e-27 95.4 0.2 5.8e-27 94.2 0.2 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001013020.2_39728001_2 - 1.5e-05 24.8 0.9 0.11 12.4 0.0 4.5 4 0 0 4 4 4 1 Cadherin-like Cadherin PF00028.15 001013008.2_39727001_1 - 2.5e-75 248.9 0.0 7.7e-16 58.2 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001013008.2_39727001_1 - 8.1e-38 128.0 0.3 8.4e-36 121.5 0.1 3.6 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.3 001013008.2_39727001_1 - 1.9e-28 98.9 0.4 3.8e-28 98.0 0.4 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001013008.2_39727001_1 - 1.9e-07 30.9 2.6 0.016 15.1 0.0 4.6 4 0 0 4 4 4 3 Cadherin-like Annexin PF00191.18 001081867.2_21023001_3 - 1e-92 304.1 11.7 5.2e-26 90.4 0.5 4.1 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.3 001081867.2_21023001_3 - 0.00023 20.8 0.7 3.2 7.6 0.0 3.4 2 1 1 3 3 3 2 Myb DNA-binding like UBA_2 PF08587.9 001081867.2_21023001_3 - 0.017 15.1 1.1 0.29 11.1 0.1 2.7 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) T4_tail_cap PF11091.6 001081867.2_21023001_3 - 0.045 12.5 0.1 7.3 5.3 0.1 2.8 1 1 2 3 3 3 0 Tail-tube assembly protein 7tm_1 PF00001.19 001081836.1_21023001_3 - 6.2e-39 133.7 12.9 6.2e-39 133.7 12.9 1.7 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) Arf PF00025.19 001109046.1_45723001_1 - 2.5e-60 202.8 0.2 3.3e-60 202.4 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 001109046.1_45723001_1 - 1.7e-15 57.2 0.3 3.6e-15 56.1 0.1 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001109046.1_45723001_1 - 1.9e-14 53.5 0.1 2.7e-14 53.0 0.1 1.2 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 001109046.1_45723001_1 - 4.8e-13 48.8 0.1 7e-13 48.3 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 001109046.1_45723001_1 - 1e-09 37.9 0.3 5.4e-07 29.0 0.2 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 001109046.1_45723001_1 - 1.2e-08 34.5 0.2 1.6e-08 34.1 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001109046.1_45723001_1 - 2.2e-06 27.6 0.0 3.8e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001109046.1_45723001_1 - 0.0097 15.3 0.1 0.098 12.1 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_14 PF13173.4 001109046.1_45723001_1 - 0.019 14.9 0.1 0.044 13.7 0.1 1.8 1 1 0 1 1 1 0 AAA domain V-set PF07686.15 104479.1_26225120_1 - 5.7e-36 122.9 0.0 6.7e-20 71.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.23 104479.1_26225120_1 - 2.1e-09 37.3 0.0 0.0027 17.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 104479.1_26225120_1 - 8.8e-09 35.7 0.0 0.003 18.0 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 104479.1_26225120_1 - 5.7e-07 29.4 0.0 0.014 15.3 0.0 2.5 1 1 1 2 2 2 2 Immunoglobulin I-set domain Izumo-Ig PF16706.3 104479.1_26225120_1 - 0.0053 16.7 0.0 0.94 9.4 0.0 2.4 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain Ig_2 PF13895.4 104479.1_26225120_1 - 0.0097 16.1 0.0 7.7 6.8 0.0 3.0 2 2 0 2 2 2 2 Immunoglobulin domain PRIMA1 PF16101.3 104479.1_26225120_1 - 0.085 12.8 0.5 0.15 11.9 0.5 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 SAA PF00277.16 001044552.1_49821001_1 - 1.5e-52 176.2 5.5 1.8e-52 176.0 5.5 1.0 1 0 0 1 1 1 1 Serum amyloid A protein Arf PF00025.19 001162545.1_39522001_1 - 3.9e-78 260.7 0.1 4.7e-78 260.5 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001162545.1_39522001_1 - 6.2e-15 54.9 0.0 7.7e-15 54.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 001162545.1_39522001_1 - 3.1e-14 53.1 0.0 4.2e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001162545.1_39522001_1 - 1.2e-12 47.7 0.0 1.3e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 001162545.1_39522001_1 - 9.7e-12 44.6 1.4 7.6e-08 31.8 0.2 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 001162545.1_39522001_1 - 5.7e-11 42.1 0.0 7.2e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001162545.1_39522001_1 - 1.5e-05 24.9 0.0 2.4e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 001162545.1_39522001_1 - 0.0033 16.6 0.6 0.021 14.0 0.1 1.9 2 0 0 2 2 2 1 6-phosphofructo-2-kinase VWA_2 PF13519.4 001104928.1_39523001_1 - 2.2e-24 86.1 1.2 9.8e-24 84.0 0.0 2.7 4 1 0 4 4 4 1 von Willebrand factor type A domain VWA PF00092.26 001104928.1_39523001_1 - 1.8e-07 31.4 0.0 5.3e-07 29.9 0.0 1.7 2 0 0 2 2 2 1 von Willebrand factor type A domain Ssl1 PF04056.12 001104928.1_39523001_1 - 4.4e-07 29.8 0.1 7.8e-07 29.0 0.1 1.3 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.18 001104928.1_39523001_1 - 4.8e-07 29.1 10.0 0.00012 21.6 0.4 3.4 3 0 0 3 3 3 2 Ubiquitin interaction motif Proteasome PF00227.24 001131030.1_39522001_1 - 7.4e-47 159.2 0.1 8.8e-47 158.9 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Synaptobrevin PF00957.19 001166204.1_39522001_1 - 8.2e-31 105.5 1.1 1.3e-30 104.9 1.1 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.4 001166204.1_39522001_1 - 2.4e-27 94.7 0.6 4.2e-27 93.9 0.6 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain PMT_4TMC PF16192.3 001166204.1_39522001_1 - 0.065 12.7 0.4 0.23 10.9 0.1 1.9 2 0 0 2 2 2 0 C-terminal four TMM region of protein-O-mannosyltransferase IlvGEDA_leader PF08046.9 001166204.1_39522001_1 - 0.24 10.7 6.7 0.48 9.8 6.7 1.5 1 0 0 1 1 1 0 IlvGEDA operon leader peptide Proteasome PF00227.24 001139446.2_39523001_3 - 3.4e-54 183.1 0.2 4.3e-54 182.8 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 001139446.2_39523001_3 - 6.1e-15 54.4 0.1 1.1e-14 53.7 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature NUDIX PF00293.26 001202421.1_39523001_1 - 1.5e-08 34.6 0.3 7.1e-08 32.4 0.3 1.9 1 1 0 1 1 1 1 NUDIX domain 7tm_1 PF00001.19 001130154.1_39523001_1 - 8.8e-71 238.1 14.8 1.1e-70 237.8 14.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001130154.1_39523001_1 - 7e-14 51.7 17.3 9.6e-14 51.2 17.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001130154.1_39523001_1 - 1.3e-07 31.6 9.2 1.3e-07 31.6 9.2 2.1 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001130154.1_39523001_1 - 2.1e-05 23.8 16.5 2.1e-05 23.8 16.5 1.4 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx MBOAT PF03062.17 001306122.1_39523001_1 - 2.1e-12 46.9 10.4 6.1e-07 29.0 7.3 2.4 2 0 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family GHMP_kinases_N PF00288.24 001306122.1_39523001_1 - 3.2 7.9 5.7 1.5 9.0 0.2 2.4 2 0 0 2 2 2 0 GHMP kinases N terminal domain HlyIII PF03006.18 001306110.1_39525001_1 - 1.3e-72 244.1 19.8 1.6e-72 243.7 19.8 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF4405 PF14358.4 001306110.1_39525001_1 - 0.026 14.9 3.2 0.026 14.9 3.2 3.3 3 1 1 4 4 4 0 Domain of unknown function (DUF4405) DUF962 PF06127.9 001306110.1_39525001_1 - 0.17 11.8 4.9 0.061 13.3 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF962) NDUFA12 PF05071.14 001145188.1_39522001_1 - 4.3e-30 104.3 4.7 5.4e-30 103.9 4.7 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 STAT_bind PF02864.13 001166203.1_39525001_1 - 6.3e-79 265.2 0.2 6.3e-79 265.2 0.2 2.1 2 1 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 001166203.1_39525001_1 - 1.1e-54 184.9 21.5 1.1e-54 184.9 21.5 2.1 2 1 0 2 2 2 1 STAT protein, all-alpha domain STAT_int PF02865.15 001166203.1_39525001_1 - 4.6e-39 133.5 7.8 4.6e-39 133.5 7.8 3.2 3 1 0 3 3 3 1 STAT protein, protein interaction domain STAT1_TAZ2bind PF12162.6 001166203.1_39525001_1 - 1e-15 56.8 1.0 2.2e-15 55.8 1.0 1.6 1 0 0 1 1 1 1 STAT1 TAZ2 binding domain SH2 PF00017.22 001166203.1_39525001_1 - 1.4e-09 37.8 0.4 1.6e-08 34.4 0.0 2.9 3 0 0 3 3 3 1 SH2 domain TRPM_tetra PF16519.3 001166203.1_39525001_1 - 0.014 15.3 7.0 0.4 10.7 0.3 2.9 2 0 0 2 2 2 0 Tetramerisation domain of TRPM PDEase_I_N PF08499.10 001166203.1_39525001_1 - 0.047 13.4 0.4 6.7 6.5 0.1 2.6 2 0 0 2 2 2 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal NPV_P10 PF05531.10 001166203.1_39525001_1 - 0.25 11.7 7.6 0.72 10.2 2.5 2.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Sec20 PF03908.11 001166203.1_39525001_1 - 0.83 9.5 7.6 13 5.7 2.6 3.2 3 0 0 3 3 3 0 Sec20 Syntaxin-6_N PF09177.9 001166203.1_39525001_1 - 0.85 10.1 5.8 1.2 9.6 1.1 2.7 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF4407 PF14362.4 001166203.1_39525001_1 - 4.1 6.5 7.4 7.1 5.8 7.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Arf PF00025.19 001162556.1_39522001_1 - 2.7e-63 212.4 0.2 3e-63 212.3 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 001162556.1_39522001_1 - 5.1e-16 58.6 0.0 5.8e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001162556.1_39522001_1 - 8e-16 58.2 0.1 1.1e-15 57.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 001162556.1_39522001_1 - 7.4e-13 48.2 0.1 8.9e-13 47.9 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 001162556.1_39522001_1 - 4.5e-10 39.1 0.4 8.6e-07 28.3 0.2 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 001162556.1_39522001_1 - 1.6e-08 34.0 0.3 2e-08 33.8 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001162556.1_39522001_1 - 9.6e-07 28.8 0.0 1.4e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001162556.1_39522001_1 - 0.0039 16.6 0.1 0.063 12.7 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_14 PF13173.4 001162556.1_39522001_1 - 0.016 15.1 0.1 0.038 13.9 0.0 1.6 1 1 1 2 2 2 0 AAA domain FeoB_N PF02421.16 001162556.1_39522001_1 - 0.031 13.7 0.8 0.12 11.8 0.8 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B TniB PF05621.9 001162556.1_39522001_1 - 0.052 12.6 0.0 0.078 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein cobW PF02492.17 001162556.1_39522001_1 - 0.11 11.9 0.1 13 5.2 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.14 001162556.1_39522001_1 - 0.16 10.8 0.0 9.5 5.0 0.0 2.1 2 0 0 2 2 2 0 ArgK protein AMH_N PF04709.10 001308599.1_39524001_2 - 1e-138 462.4 1.9 1.3e-138 462.1 1.9 1.1 1 0 0 1 1 1 1 Anti-Mullerian hormone, N terminal region TGF_beta PF00019.18 001308599.1_39524001_2 - 7.9e-16 58.7 0.3 1.1e-15 58.2 0.3 1.2 1 0 0 1 1 1 1 Transforming growth factor beta like domain EF-hand_1 PF00036.30 001141954.2_39522001_3 - 1.4e-13 49.2 2.5 6.6e-06 25.2 1.2 3.7 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 001141954.2_39522001_3 - 2.4e-10 39.3 2.9 2e-06 27.1 1.0 3.2 2 1 1 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 001141954.2_39522001_3 - 4.2e-09 36.6 0.4 0.00014 22.2 0.1 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 001141954.2_39522001_3 - 4.8e-07 29.3 1.6 0.02 14.5 0.2 4.0 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.4 001141954.2_39522001_3 - 0.0044 16.4 1.5 0.0044 16.4 1.5 2.3 2 0 0 2 2 2 1 EF hand Caleosin PF05042.11 001141954.2_39522001_3 - 0.061 13.1 0.1 12 5.6 0.0 2.6 2 1 1 3 3 3 0 Caleosin related protein Synuclein PF01387.15 001252184.1_39521001_1 - 2.3e-52 176.6 18.2 2.7e-52 176.4 18.2 1.0 1 0 0 1 1 1 1 Synuclein DUF659 PF04937.13 001252184.1_39521001_1 - 0.12 12.1 0.7 0.15 11.8 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) ARL2_Bind_BART PF11527.6 001162551.1_39521001_1 - 1.7e-34 118.2 6.9 2.1e-34 118.0 6.9 1.1 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART Guanylin PF02058.13 001105261.1_39521001_3 - 1.6e-35 121.3 0.4 2e-35 121.0 0.4 1.1 1 0 0 1 1 1 1 Guanylin precursor ICAM_N PF03921.12 001009731.1_39524001_1 - 3e-32 110.0 0.0 9.1e-32 108.5 0.0 1.9 2 0 0 2 2 2 1 Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 PF13895.4 001009731.1_39524001_1 - 8e-10 38.8 0.1 0.35 11.1 0.0 5.1 5 0 0 5 5 5 3 Immunoglobulin domain C2-set_2 PF08205.10 001009731.1_39524001_1 - 5.3e-08 32.7 2.7 0.0073 16.2 0.0 5.0 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 001009731.1_39524001_1 - 5.5e-06 26.8 6.1 0.035 14.6 0.1 5.0 5 2 0 5 5 5 2 Immunoglobulin domain ig PF00047.23 001009731.1_39524001_1 - 0.00029 20.8 0.9 3.5 7.7 0.0 5.2 6 0 0 6 6 6 1 Immunoglobulin domain I-set PF07679.14 001009731.1_39524001_1 - 0.0016 18.4 0.0 7.5 6.6 0.0 4.4 5 1 0 5 5 5 1 Immunoglobulin I-set domain COX14 PF14880.4 001009731.1_39524001_1 - 0.15 11.8 0.1 0.25 11.1 0.1 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Laminin_EGF PF00053.22 001142358.1_39528001_1 - 7.9e-43 144.3 151.5 3.1e-10 39.9 14.4 8.7 9 0 0 9 9 9 8 Laminin EGF domain Laminin_B PF00052.16 001142358.1_39528001_1 - 9.3e-31 106.4 0.4 4.3e-29 101.0 0.0 3.3 3 0 0 3 3 3 1 Laminin B (Domain IV) IFP_35_N PF07334.11 001142358.1_39528001_1 - 0.0022 17.9 1.8 0.39 10.7 0.0 2.8 2 0 0 2 2 2 2 Interferon-induced 35 kDa protein (IFP 35) N-terminus Spc7 PF08317.9 001142358.1_39528001_1 - 1.8 7.2 40.2 0.25 10.0 0.2 4.4 2 1 0 4 4 4 0 Spc7 kinetochore protein Arf PF00025.19 001162558.1_39522001_1 - 1.7e-46 157.8 0.1 2e-46 157.5 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 001162558.1_39522001_1 - 1.6e-18 66.7 0.0 1.9e-18 66.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001162558.1_39522001_1 - 8e-17 61.4 0.0 1.2e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.10 001162558.1_39522001_1 - 1.2e-09 37.7 0.0 1.4e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001162558.1_39522001_1 - 2.5e-08 33.4 0.0 3e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 001162558.1_39522001_1 - 5.8e-08 32.1 0.2 4.1e-05 22.8 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.21 001162558.1_39522001_1 - 1.1e-06 28.6 0.0 8.6e-06 25.7 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.21 001162558.1_39522001_1 - 0.011 15.7 0.1 2.8 7.8 0.1 2.7 2 1 1 3 3 3 0 Dynamin family Cyt-b5 PF00173.26 001308580.1_39523001_3 - 3.7e-14 52.5 0.0 6e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NDUF_B6 PF09782.7 001185123.1_39521001_1 - 1.6e-51 174.4 1.5 1.8e-51 174.2 1.5 1.0 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit DUF735 PF05246.9 001185123.1_39521001_1 - 0.18 11.6 0.1 0.23 11.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF735) Sensor PF13796.4 001185123.1_39521001_1 - 0.19 11.6 0.2 0.22 11.4 0.2 1.1 1 0 0 1 1 1 0 Putative sensor IL23 PF16649.3 001185122.2_39522001_1 - 2.5e-95 316.7 0.2 3.3e-95 316.3 0.2 1.1 1 0 0 1 1 1 1 Interleukin 23 subunit alpha IL6 PF00489.15 001185122.2_39522001_1 - 0.056 12.9 0.0 0.12 11.8 0.0 1.6 1 1 0 1 1 1 0 Interleukin-6/G-CSF/MGF family Arf PF00025.19 001162544.1_39522001_1 - 3.7e-79 264.1 0.1 4.3e-79 263.9 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001162544.1_39522001_1 - 6.2e-15 54.9 0.0 7.7e-15 54.6 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 001162544.1_39522001_1 - 3e-14 53.1 0.0 4.2e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001162544.1_39522001_1 - 6.4e-13 48.5 0.0 6.9e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 001162544.1_39522001_1 - 9.1e-12 44.7 1.1 6.9e-08 31.9 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 001162544.1_39522001_1 - 5.2e-11 42.2 0.0 6.2e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001162544.1_39522001_1 - 1.5e-05 24.9 0.0 2.3e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 001162544.1_39522001_1 - 0.0031 16.7 0.5 0.022 14.0 0.1 1.9 2 0 0 2 2 2 1 6-phosphofructo-2-kinase Basic PF01586.14 001134782.1_39522001_2 - 6.8e-23 81.5 0.1 2.1e-22 79.9 0.0 1.9 2 1 1 3 3 3 1 Myogenic Basic domain HLH PF00010.24 001134782.1_39522001_2 - 4.4e-13 48.9 6.3 7e-13 48.2 6.3 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Myf5 PF12232.6 001134782.1_39522001_2 - 0.0021 18.6 2.0 0.0021 18.6 2.0 1.8 2 0 0 2 2 2 1 Myogenic determination factor 5 fn3 PF00041.19 001252175.1_39526001_1 - 4.1e-23 81.4 2.1 6.2e-06 26.3 0.0 5.8 5 1 0 5 5 5 4 Fibronectin type III domain Lep_receptor_Ig PF06328.9 001252175.1_39526001_1 - 2.8e-10 40.0 0.0 6.9e-10 38.7 0.0 1.7 1 0 0 1 1 1 1 Ig-like C2-type domain IL6Ra-bind PF09240.8 001252175.1_39526001_1 - 0.0014 18.9 0.2 0.006 16.8 0.1 2.3 2 0 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding Pur_ac_phosph_N PF16656.3 001252175.1_39526001_1 - 0.011 16.1 0.1 0.98 9.9 0.0 2.9 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain IL1 PF00340.17 001308595.1_39523001_1 - 1.4e-33 115.0 0.0 2.1e-33 114.4 0.0 1.3 1 0 0 1 1 1 1 Interleukin-1 / 18 Arf PF00025.19 001162548.1_39522001_1 - 1.4e-78 262.2 0.0 1.5e-78 262.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 001162548.1_39522001_1 - 4.4e-15 55.9 0.0 5.8e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001162548.1_39522001_1 - 2.3e-14 53.2 0.0 2.5e-14 53.0 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 001162548.1_39522001_1 - 3.2e-13 49.4 0.0 3.9e-13 49.1 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 001162548.1_39522001_1 - 1.7e-12 47.1 1.0 4.1e-08 32.7 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 001162548.1_39522001_1 - 1.4e-10 40.8 0.0 1.8e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001162548.1_39522001_1 - 0.0001 22.2 0.0 0.00015 21.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 001162548.1_39522001_1 - 0.0049 16.1 0.2 0.0076 15.4 0.2 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase SpoOE-like PF09388.8 001162548.1_39522001_1 - 0.021 14.6 1.2 0.039 13.7 1.2 1.4 1 0 0 1 1 1 0 Spo0E like sporulation regulatory protein CRISPR_Cas2 PF09827.7 001162548.1_39522001_1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 CRISPR associated protein Cas2 Pkinase PF00069.23 001142514.1_39524001_3 - 1e-50 172.4 0.0 1.5e-50 171.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001142514.1_39524001_3 - 1e-49 169.1 0.0 1.6e-49 168.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Death PF00531.20 001142514.1_39524001_3 - 0.023 14.7 0.0 0.062 13.3 0.0 1.7 1 0 0 1 1 1 0 Death domain Arf PF00025.19 001162546.1_39522001_1 - 4.6e-77 257.3 0.2 5.3e-77 257.1 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001162546.1_39522001_1 - 1.4e-14 53.8 0.0 1.8e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 001162546.1_39522001_1 - 3.1e-14 53.1 0.0 4.5e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001162546.1_39522001_1 - 1.4e-13 50.6 0.0 1.5e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 001162546.1_39522001_1 - 7.4e-13 48.3 1.2 5.7e-09 35.5 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 001162546.1_39522001_1 - 1.1e-10 41.1 0.0 1.3e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001162546.1_39522001_1 - 2.4e-05 24.2 0.1 5.5e-05 23.1 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase 6PF2K PF01591.16 001162546.1_39522001_1 - 0.0071 15.5 0.2 0.012 14.8 0.1 1.4 2 0 0 2 2 2 1 6-phosphofructo-2-kinase Arf PF00025.19 001126365.1_39522001_1 - 2.3e-67 225.7 0.0 2.7e-67 225.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 001126365.1_39522001_1 - 1.6e-17 63.5 0.0 1.7e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001126365.1_39522001_1 - 2.2e-17 63.2 0.1 3e-17 62.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 001126365.1_39522001_1 - 5.4e-12 45.4 0.9 6e-12 45.2 0.0 1.4 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 001126365.1_39522001_1 - 7.7e-08 32.3 0.1 1.1e-07 31.8 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.18 001126365.1_39522001_1 - 8.3e-08 31.6 0.4 3.6e-06 26.3 0.1 2.3 1 1 1 2 2 2 1 G-protein alpha subunit GTP_EFTU PF00009.25 001126365.1_39522001_1 - 0.00015 21.3 0.1 0.00038 19.9 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001126365.1_39522001_1 - 0.00016 21.0 0.1 0.00024 20.4 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.15 001126365.1_39522001_1 - 0.013 15.2 0.0 0.04 13.5 0.0 1.6 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein 6PF2K PF01591.16 001126365.1_39522001_1 - 0.023 13.9 0.0 0.036 13.2 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_28 PF13521.4 001126365.1_39522001_1 - 0.028 14.5 0.1 0.29 11.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.14 001126365.1_39522001_1 - 0.031 14.0 0.2 0.47 10.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 NTPase_1 PF03266.13 001126365.1_39522001_1 - 0.15 11.9 1.3 0.41 10.4 0.8 1.8 1 1 1 2 2 2 0 NTPase Reticulon PF02453.15 001162557.1_39522001_1 - 8.2e-05 22.5 1.9 0.00011 22.0 1.9 1.1 1 0 0 1 1 1 1 Reticulon TraG_N PF07916.9 001162557.1_39522001_1 - 0.096 11.4 3.9 0.5 9.0 0.2 2.2 2 0 0 2 2 2 0 TraG-like protein, N-terminal region Arf PF00025.19 001162559.1_39522001_1 - 3.8e-47 159.9 0.1 4.4e-47 159.6 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 001162559.1_39522001_1 - 1.5e-19 70.0 0.0 1.8e-19 69.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001162559.1_39522001_1 - 6.6e-17 61.7 0.0 1e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.10 001162559.1_39522001_1 - 1.1e-10 41.1 0.0 1.3e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001162559.1_39522001_1 - 8.9e-08 31.6 0.0 1e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 001162559.1_39522001_1 - 1e-07 31.3 0.4 7.9e-05 21.8 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.21 001162559.1_39522001_1 - 5.4e-06 26.4 0.0 9.1e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase VirE PF05272.9 001162559.1_39522001_1 - 0.042 13.4 0.0 0.064 12.8 0.0 1.3 1 0 0 1 1 1 0 Virulence-associated protein E Dynamin_N PF00350.21 001162559.1_39522001_1 - 0.11 12.4 0.1 3.5 7.5 0.1 2.1 1 1 1 2 2 2 0 Dynamin family V-set PF07686.15 001306108.1_39525001_1 - 4.6e-08 33.0 0.6 0.0088 16.1 0.1 2.9 3 0 0 3 3 3 2 Immunoglobulin V-set domain ig PF00047.23 001306108.1_39525001_1 - 1.1e-06 28.6 7.3 0.013 15.5 0.0 3.7 4 1 0 4 4 4 2 Immunoglobulin domain Ig_3 PF13927.4 001306108.1_39525001_1 - 9.6e-06 26.0 9.1 0.0011 19.4 0.0 5.2 4 1 1 5 5 5 1 Immunoglobulin domain C2-set_2 PF08205.10 001306108.1_39525001_1 - 0.00033 20.5 0.0 0.0084 16.0 0.0 3.0 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 001306108.1_39525001_1 - 0.014 15.6 5.9 0.49 10.6 0.2 4.6 4 2 1 5 5 5 0 Immunoglobulin domain I-set PF07679.14 001306108.1_39525001_1 - 0.024 14.5 0.0 5.2 7.1 0.0 3.4 2 1 0 2 2 2 0 Immunoglobulin I-set domain Arm PF00514.21 001308590.1_39529001_1 - 8.7e-39 130.3 20.5 1.9e-07 30.8 0.1 11.6 13 0 0 13 13 13 6 Armadillo/beta-catenin-like repeat Cnd1 PF12717.5 001308590.1_39529001_1 - 1e-07 31.9 1.9 0.0078 16.1 0.4 4.2 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.18 001308590.1_39529001_1 - 7.2e-06 24.7 1.7 0.0021 16.6 1.0 3.0 3 0 0 3 3 3 2 Adaptin N terminal region HEAT_2 PF13646.4 001308590.1_39529001_1 - 2.4e-05 24.5 5.2 0.059 13.6 0.2 4.6 5 0 0 5 5 5 1 HEAT repeats HEAT_EZ PF13513.4 001308590.1_39529001_1 - 3.8e-05 23.9 6.9 2.3 8.7 0.0 5.9 5 1 1 6 6 6 1 HEAT-like repeat HEAT PF02985.20 001308590.1_39529001_1 - 5e-05 23.1 1.5 33 4.9 0.0 5.6 5 0 0 5 5 5 0 HEAT repeat Atx10homo_assoc PF09759.7 001308590.1_39529001_1 - 0.0057 16.6 1.4 0.025 14.5 0.1 2.7 3 1 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain RasGEF_N_2 PF14663.4 001308590.1_39529001_1 - 0.014 15.6 3.7 12 6.1 0.0 4.3 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF3361 PF11841.6 001308590.1_39529001_1 - 0.021 14.6 1.4 11 5.8 0.0 4.1 2 1 1 4 4 4 0 Domain of unknown function (DUF3361) Queuosine_synth PF02547.13 001308590.1_39529001_1 - 0.038 13.0 0.1 0.08 11.9 0.1 1.4 1 0 0 1 1 1 0 Queuosine biosynthesis protein Arm_2 PF04826.11 001308590.1_39529001_1 - 0.087 12.1 2.9 1.5 8.1 0.0 3.1 2 1 1 3 3 3 0 Armadillo-like NDUF_B8 PF05821.9 001177679.1_39522001_1 - 2.6e-80 268.4 7.7 2.9e-80 268.2 7.7 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Insulin PF00049.16 001024738.1_39521001_1 - 5.9e-07 30.3 3.2 6.3e-06 27.0 3.2 2.0 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 001024738.1_39521001_1 - 0.00017 21.4 0.9 0.19 11.6 0.1 2.2 2 0 0 2 2 2 2 Nematode insulin-related peptide beta type Arf PF00025.19 001162554.1_39522001_1 - 8.3e-62 207.6 0.0 9.3e-62 207.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 001162554.1_39522001_1 - 4.7e-16 59.0 0.0 6.1e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001162554.1_39522001_1 - 1.1e-15 57.5 0.0 1.3e-15 57.3 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 001162554.1_39522001_1 - 4.5e-11 42.4 0.0 6.9e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 001162554.1_39522001_1 - 2.2e-08 33.5 0.1 1e-05 24.7 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.21 001162554.1_39522001_1 - 8.6e-08 32.1 0.0 1.2e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001162554.1_39522001_1 - 0.00026 20.4 0.0 0.00086 18.8 0.0 1.7 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001162554.1_39522001_1 - 0.0021 17.3 0.0 0.003 16.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region 6PF2K PF01591.16 001162554.1_39522001_1 - 0.12 11.5 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Chromo_shadow PF01393.17 001166190.1_39522001_1 - 6.9e-31 105.9 0.8 2.2e-27 94.7 0.0 2.4 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.22 001166190.1_39522001_1 - 4.7e-20 71.1 1.1 1.6e-17 63.0 0.8 2.7 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.4 001166190.1_39522001_1 - 0.0035 17.3 0.1 0.011 15.7 0.3 1.8 2 0 0 2 2 2 1 Polycomb-like MTF2 factor 2 BST2 PF16716.3 001178050.1_39521001_1 - 7.8e-23 80.7 12.6 7.8e-23 80.7 12.6 1.5 2 0 0 2 2 1 1 Bone marrow stromal antigen 2 Bap31 PF05529.10 001178050.1_39521001_1 - 0.0017 17.9 3.1 0.0024 17.4 3.1 1.4 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like CENP-F_leu_zip PF10473.7 001178050.1_39521001_1 - 0.0035 17.2 9.7 0.0049 16.8 9.7 1.1 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HemX PF04375.12 001178050.1_39521001_1 - 0.0043 16.3 3.9 0.0052 16.0 3.9 1.1 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase DUF2353 PF09789.7 001178050.1_39521001_1 - 0.0059 15.9 7.4 0.0075 15.6 7.4 1.0 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) Helicase_IV_N PF12462.6 001178050.1_39521001_1 - 0.0061 16.4 1.9 0.0083 15.9 1.9 1.2 1 0 0 1 1 1 1 DNA helicase IV / RNA helicase N terminal Tropomyosin PF00261.18 001178050.1_39521001_1 - 0.009 15.3 8.8 0.012 14.9 8.8 1.1 1 0 0 1 1 1 1 Tropomyosin DASH_Duo1 PF08651.8 001178050.1_39521001_1 - 0.0099 15.5 0.9 0.02 14.5 0.9 1.5 1 0 0 1 1 1 1 DASH complex subunit Duo1 DUF3450 PF11932.6 001178050.1_39521001_1 - 0.018 14.2 4.7 0.024 13.8 4.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Med9 PF07544.11 001178050.1_39521001_1 - 0.018 14.9 4.6 0.037 14.0 4.6 1.6 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 CLN3 PF02487.15 001178050.1_39521001_1 - 0.021 13.8 0.1 0.026 13.5 0.1 1.1 1 0 0 1 1 1 0 CLN3 protein CLZ PF16526.3 001178050.1_39521001_1 - 0.022 14.9 3.9 0.022 14.9 3.9 1.6 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels OmpH PF03938.12 001178050.1_39521001_1 - 0.033 14.1 4.7 0.045 13.6 4.7 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4381 PF14316.4 001178050.1_39521001_1 - 0.051 13.7 3.9 0.099 12.8 1.9 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4381) EMP24_GP25L PF01105.22 001178050.1_39521001_1 - 0.07 12.9 2.8 0.14 12.0 2.7 1.6 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Fib_alpha PF08702.8 001178050.1_39521001_1 - 0.094 12.8 8.0 0.12 12.4 8.0 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Spc7 PF08317.9 001178050.1_39521001_1 - 0.1 11.3 9.8 0.12 11.1 9.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF87 PF01935.15 001178050.1_39521001_1 - 0.11 12.4 0.3 0.13 12.1 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF87 Exonuc_VII_L PF02601.13 001178050.1_39521001_1 - 0.12 11.8 6.1 0.15 11.5 6.1 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit GrpE PF01025.17 001178050.1_39521001_1 - 0.13 11.8 9.4 0.033 13.7 2.1 2.0 1 1 1 2 2 2 0 GrpE Fzo_mitofusin PF04799.11 001178050.1_39521001_1 - 0.27 10.6 4.2 0.4 10.0 4.2 1.4 1 0 0 1 1 1 0 fzo-like conserved region Phage_GPO PF05929.9 001178050.1_39521001_1 - 0.28 10.7 5.9 0.33 10.4 5.9 1.0 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase HIP1_clath_bdg PF16515.3 001178050.1_39521001_1 - 0.29 11.6 12.9 0.47 11.0 12.7 1.4 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4407 PF14362.4 001178050.1_39521001_1 - 0.48 9.6 8.2 0.67 9.1 8.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMPIT PF07851.11 001178050.1_39521001_1 - 0.51 9.4 3.0 0.7 9.0 3.0 1.2 1 0 0 1 1 1 0 TMPIT-like protein APG6 PF04111.10 001178050.1_39521001_1 - 0.86 8.8 10.3 1.1 8.4 10.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 GAS PF13851.4 001178050.1_39521001_1 - 1.3 8.2 13.9 0.98 8.6 5.0 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding CENP-H PF05837.10 001178050.1_39521001_1 - 3.8 7.8 11.6 0.71 10.2 5.3 1.9 1 1 1 2 2 2 0 Centromere protein H (CENP-H) FUSC PF04632.10 001178050.1_39521001_1 - 7.1 4.9 7.8 3.6 5.9 6.3 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family SIR2 PF02146.15 001163044.1_39522001_1 - 1.1e-53 181.6 0.0 1.6e-53 181.1 0.0 1.2 1 0 0 1 1 1 1 Sir2 family zf-dskA_traR PF01258.15 001163044.1_39522001_1 - 0.32 10.8 1.7 12 5.8 0.1 3.0 3 0 0 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger MHC_I PF00129.16 001308452.1_39523001_1 - 6.3e-91 302.7 0.4 8.9e-91 302.2 0.4 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001308452.1_39523001_1 - 1.9e-17 63.4 0.0 4e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001308452.1_39523001_1 - 1.1e-16 60.2 1.3 2.3e-16 59.3 1.3 1.6 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001308452.1_39523001_1 - 9.7e-06 26.0 0.3 0.00029 21.3 0.0 2.9 1 1 1 2 2 2 1 Immunoglobulin domain ig PF00047.23 001308452.1_39523001_1 - 0.00034 20.6 0.3 0.0014 18.7 0.0 2.1 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.4 001308452.1_39523001_1 - 0.0009 19.4 0.0 0.0075 16.5 0.0 2.5 3 0 0 3 3 3 1 Immunoglobulin domain MHC_I_3 PF16497.3 001308452.1_39523001_1 - 0.0011 18.4 0.0 0.0017 17.8 0.0 1.3 1 0 0 1 1 1 1 MHC-I family domain C2-set_2 PF08205.10 001308452.1_39523001_1 - 0.0031 17.4 0.1 0.006 16.5 0.1 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain EphA2_TM PF14575.4 001308452.1_39523001_1 - 0.037 14.7 0.1 0.082 13.6 0.1 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4245 PF14030.4 001308452.1_39523001_1 - 0.23 11.3 2.1 9.6 6.1 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4245) P12 PF12669.5 001308452.1_39523001_1 - 0.69 10.2 2.3 1.3 9.3 2.3 1.4 1 0 0 1 1 1 0 Virus attachment protein p12 family Keratin_B2 PF01500.15 001159760.1_39522001_1 - 1.5e-70 236.3 114.9 2e-69 232.7 114.9 2.1 1 1 0 1 1 1 1 Keratin, high sulfur B2 protein Keratin_B2_2 PF13885.4 001159760.1_39522001_1 - 3.9e-14 52.2 160.3 6.4e-06 25.9 40.3 5.1 2 2 2 4 4 4 4 Keratin, high sulfur B2 protein MBOAT PF03062.17 001110164.1_39523001_1 - 8.1e-66 222.6 16.3 8.1e-66 222.6 16.3 1.5 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family GATA PF00320.25 001252183.1_39524001_1 - 5.8e-29 99.3 19.6 1.8e-14 52.9 5.3 2.4 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.10 001252183.1_39524001_1 - 2.3e-05 23.7 8.0 0.024 14.0 0.7 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.8 001252183.1_39524001_1 - 0.019 14.9 2.1 3 7.9 0.1 2.8 2 0 0 2 2 2 0 Zinc ribbon domain Auto_anti-p27 PF06677.10 001252183.1_39524001_1 - 0.033 14.2 5.1 0.44 10.6 0.4 2.4 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF2387 PF09526.8 001252183.1_39524001_1 - 0.051 13.6 5.1 2.7 8.1 0.5 3.1 1 1 2 3 3 3 0 Probable metal-binding protein (DUF2387) Prim_Zn_Ribbon PF08273.10 001252183.1_39524001_1 - 0.96 9.7 11.5 0.32 11.3 2.7 2.8 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DZR PF12773.5 001252183.1_39524001_1 - 1.4 8.8 11.7 5.2 7.1 1.6 3.0 1 1 2 3 3 3 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.9 001252183.1_39524001_1 - 2 8.3 10.2 2.6 7.9 0.8 3.0 3 0 0 3 3 3 0 Putative transposase DNA-binding domain eIF-5_eIF-2B PF01873.15 001252183.1_39524001_1 - 2.2 8.0 5.9 18 5.1 1.2 2.3 2 0 0 2 2 2 0 Domain found in IF2B/IF5 TIMP PF00965.15 001166186.1_39522001_1 - 2.2e-73 245.8 4.7 2.5e-73 245.6 4.7 1.0 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.19 001166186.1_39522001_1 - 0.00048 19.8 0.1 0.0019 17.8 0.0 2.0 1 1 1 2 2 2 1 UNC-6/NTR/C345C module MHC_II_alpha PF00993.18 001308598.1_39522001_3 - 1.3e-36 124.0 0.0 1.8e-36 123.5 0.0 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001308598.1_39522001_3 - 2.6e-29 100.3 0.9 4.8e-29 99.4 0.9 1.5 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001308598.1_39522001_3 - 1.7e-23 82.8 0.0 2.6e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001308598.1_39522001_3 - 4.9e-07 30.1 0.0 8.1e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001308598.1_39522001_3 - 0.0014 18.4 0.1 0.0021 17.8 0.1 1.2 1 0 0 1 1 1 1 Marek's disease glycoprotein A Ig_2 PF13895.4 001308598.1_39522001_3 - 0.0092 16.2 0.0 0.016 15.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001308598.1_39522001_3 - 0.12 12.4 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain SKG6 PF08693.8 001308598.1_39522001_3 - 0.26 10.6 2.5 0.57 9.5 2.5 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Pkinase PF00069.23 001306113.1_39527001_1 - 6.2e-62 209.2 0.8 1.2e-39 136.2 0.0 3.1 4 0 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.15 001306113.1_39527001_1 - 4.5e-28 98.1 0.0 7.5e-20 71.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase UBA PF00627.29 001306113.1_39527001_1 - 3e-10 39.7 1.5 6.5e-10 38.6 0.2 2.2 2 0 0 2 2 2 1 UBA/TS-N domain Kinase-like PF14531.4 001306113.1_39527001_1 - 0.0028 16.9 0.1 0.013 14.7 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.21 001306113.1_39527001_1 - 0.004 17.0 0.4 0.019 14.7 0.3 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Cas_Cas6 PF01881.14 001306113.1_39527001_1 - 0.023 15.1 1.1 0.045 14.2 1.1 1.4 1 0 0 1 1 1 0 CRISPR associated protein Cas6 Pkinase_C PF00433.22 001306113.1_39527001_1 - 0.035 14.7 1.6 0.22 12.1 1.6 2.5 1 0 0 1 1 1 0 Protein kinase C terminal domain Pox_ser-thr_kin PF05445.9 001306113.1_39527001_1 - 0.069 12.0 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase UBA_3 PF09288.8 001306113.1_39527001_1 - 0.07 12.8 0.0 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain Mo-nitro_C PF06967.9 001306113.1_39527001_1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Mo-dependent nitrogenase C-terminus Glyco_transf_29 PF00777.16 001306114.1_39523001_3 - 4.2e-74 249.2 0.0 5.6e-74 248.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Cornichon PF03311.12 001306114.1_39523001_3 - 0.049 13.8 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Cornichon protein DUF2116 PF09889.7 001306114.1_39523001_3 - 0.27 11.1 1.2 0.5 10.3 0.1 2.0 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) PMP22_Claudin PF00822.18 001185017.1_39522001_1 - 7.3e-34 116.9 10.0 8.5e-34 116.7 10.0 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001185017.1_39522001_1 - 1.5e-10 41.1 12.5 2.3e-09 37.1 12.5 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction L_HMGIC_fpl PF10242.7 001185017.1_39522001_1 - 0.0065 16.6 10.2 0.011 15.8 10.2 1.4 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein TMEM37 PF15108.4 001185017.1_39522001_1 - 0.0073 16.1 4.9 0.011 15.5 4.9 1.3 1 0 0 1 1 1 1 Voltage-dependent calcium channel gamma-like subunit protein family DUF4131 PF13567.4 001185017.1_39522001_1 - 0.012 15.0 0.1 0.012 15.0 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) Clc-like PF07062.10 001185017.1_39522001_1 - 0.088 12.1 8.1 0.44 9.9 0.8 2.1 2 0 0 2 2 2 0 Clc-like DUF4064 PF13273.4 001185017.1_39522001_1 - 0.59 10.4 11.8 0.51 10.6 8.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) DUF3185 PF11381.6 001185017.1_39522001_1 - 0.98 9.3 17.2 11 6.0 7.0 3.7 3 1 0 3 3 3 0 Protein of unknown function (DUF3185) Asp PF00026.21 001082598.1_39523001_1 - 5e-102 341.4 0.0 5.9e-102 341.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001082598.1_39523001_1 - 3.1e-14 53.5 0.1 2.9e-07 30.8 0.0 2.3 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001082598.1_39523001_1 - 8.1e-13 47.8 2.4 1.4e-12 47.1 2.4 1.4 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.4 001082598.1_39523001_1 - 0.00063 20.2 0.0 0.014 16.0 0.0 2.9 2 1 0 2 2 2 1 Aspartyl protease Peptidase_C1_2 PF03051.13 001082598.1_39523001_1 - 0.23 10.1 0.0 0.31 9.6 0.0 1.1 1 0 0 1 1 1 0 Peptidase C1-like family AKAP2_C PF15304.4 001204120.1_29629001_1 - 4.1e-14 52.5 4.9 4.1e-14 52.5 4.9 2.7 2 1 0 2 2 2 1 A-kinase anchor protein 2 C-terminus SUIM_assoc PF16619.3 001204120.1_29629001_1 - 4.6 7.3 14.3 0.67 10.0 7.5 2.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Mito_carr PF00153.25 001194642.1_29623001_2 - 1.8e-32 111.0 0.0 1.9e-10 40.4 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Filament PF00038.19 001193952.1_29624001_2 - 1.5e-114 382.7 38.2 1.8e-114 382.4 38.2 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001193952.1_29624001_2 - 2.3e-10 40.7 19.5 1.1e-08 35.3 0.1 3.1 2 1 1 3 3 3 2 Keratin type II head TPR_MLP1_2 PF07926.10 001193952.1_29624001_2 - 1.5e-05 25.0 0.7 1.5e-05 25.0 0.7 3.8 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein TSNAXIP1_N PF15739.3 001193952.1_29624001_2 - 0.00033 20.9 1.5 0.00033 20.9 1.5 4.0 4 1 0 4 4 4 1 Translin-associated factor X-interacting N-terminus AAA_13 PF13166.4 001193952.1_29624001_2 - 0.00084 18.0 16.9 0.00084 18.0 16.9 1.6 1 1 0 1 1 1 1 AAA domain Spc7 PF08317.9 001193952.1_29624001_2 - 0.00098 18.0 36.8 0.0035 16.1 8.3 3.2 1 1 2 3 3 3 2 Spc7 kinetochore protein CENP-F_leu_zip PF10473.7 001193952.1_29624001_2 - 0.0027 17.6 32.4 0.012 15.4 11.2 3.6 1 1 3 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prefoldin PF02996.15 001193952.1_29624001_2 - 0.0056 16.4 2.6 0.0056 16.4 2.6 4.9 2 2 1 5 5 5 1 Prefoldin subunit DUF5082 PF16888.3 001193952.1_29624001_2 - 0.0088 16.3 20.6 0.014 15.6 0.6 3.3 2 1 0 3 3 3 2 Domain of unknown function (DUF5082) ISG65-75 PF11727.6 001193952.1_29624001_2 - 0.02 14.0 4.5 0.047 12.8 4.5 1.6 1 0 0 1 1 1 0 Invariant surface glycoprotein ATG16 PF08614.9 001193952.1_29624001_2 - 0.037 14.1 32.9 0.016 15.3 8.1 2.9 1 1 1 3 3 3 0 Autophagy protein 16 (ATG16) CALCOCO1 PF07888.9 001193952.1_29624001_2 - 0.039 12.4 36.0 1.5 7.1 36.0 2.1 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like She9_MDM33 PF05546.9 001193952.1_29624001_2 - 0.058 13.1 11.7 0.98 9.1 0.2 2.6 2 1 0 2 2 2 0 She9 / Mdm33 family Reo_sigmaC PF04582.10 001193952.1_29624001_2 - 0.073 12.3 7.2 1.5 8.0 1.6 2.4 1 1 0 2 2 2 0 Reovirus sigma C capsid protein IncA PF04156.12 001193952.1_29624001_2 - 0.15 11.7 38.5 1.8 8.2 6.3 3.3 1 1 2 3 3 3 0 IncA protein NPV_P10 PF05531.10 001193952.1_29624001_2 - 0.23 11.8 9.7 3.2 8.1 0.1 4.2 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein FPP PF05911.9 001193952.1_29624001_2 - 0.24 9.5 27.3 0.8 7.7 7.1 2.2 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Baculo_PEP_C PF04513.10 001193952.1_29624001_2 - 0.28 11.1 14.6 4.6 7.2 3.8 3.4 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ADIP PF11559.6 001193952.1_29624001_2 - 0.28 11.1 31.4 0.69 9.9 4.1 3.8 1 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Jnk-SapK_ap_N PF09744.7 001193952.1_29624001_2 - 0.3 11.2 33.1 0.15 12.1 3.6 3.4 2 1 0 3 3 3 0 JNK_SAPK-associated protein-1 CLZ PF16526.3 001193952.1_29624001_2 - 0.78 10.0 23.4 0.11 12.7 0.6 5.0 3 2 2 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Rootletin PF15035.4 001193952.1_29624001_2 - 1.6 8.7 29.5 0.5 10.3 11.8 3.1 1 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Snapin_Pallidin PF14712.4 001193952.1_29624001_2 - 1.8 8.9 19.2 3.4 8.0 1.5 4.9 4 1 1 5 5 5 0 Snapin/Pallidin Golgin_A5 PF09787.7 001193952.1_29624001_2 - 2.1 7.6 31.2 2.5 7.4 15.4 2.6 1 1 1 2 2 2 0 Golgin subfamily A member 5 TRAF_BIRC3_bd PF16673.3 001193952.1_29624001_2 - 3 7.6 11.1 9 6.0 0.1 4.1 3 1 1 4 4 4 0 TNF receptor-associated factor BIRC3 binding domain DUF4988 PF16378.3 001193952.1_29624001_2 - 4.1 6.8 10.1 1.3 8.5 0.3 3.7 4 0 0 4 4 4 0 Domain of unknown function Alanine_zipper PF11839.6 001193952.1_29624001_2 - 8.1 6.7 18.7 0.45 10.7 12.1 2.4 2 2 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein Cob_adeno_trans PF01923.16 001193952.1_29624001_2 - 9.3 6.2 12.9 32 4.5 9.9 2.7 1 1 1 2 2 2 0 Cobalamin adenosyltransferase DUF4707 PF15806.3 001194207.1_29626001_2 - 1.8e-247 821.3 0.3 2.1e-247 821.1 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4707) Ribosomal_L20 PF00453.16 001260920.1_29622001_1 - 4.5e-36 123.0 3.1 6.4e-36 122.6 3.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L20 Atracotoxin PF05353.9 001260920.1_29622001_2 - 0.11 12.4 6.0 0.21 11.5 6.0 1.3 1 0 0 1 1 1 0 Delta Atracotoxin Defensin_propep PF00879.16 001032921.1_29621001_2 - 3.2e-26 91.3 4.9 5.3e-26 90.6 4.9 1.3 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001032921.1_29621001_2 - 0.4 11.1 15.1 0.13 12.7 11.7 1.9 2 0 0 2 2 2 0 Mammalian defensin zf-C3HC4_3 PF13920.4 001266883.2_29626001_2 - 2.5e-12 46.3 13.0 2.5e-12 46.3 13.0 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001266883.2_29626001_2 - 4.2e-06 26.4 11.5 1.1e-05 25.1 11.5 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.4 001266883.2_29626001_2 - 0.0035 17.4 14.3 0.0035 17.4 14.3 2.1 2 0 0 2 2 2 1 Ring finger domain DUF4693 PF15764.3 001193760.1_29623001_1 - 2.8e-141 470.0 6.4 3.7e-141 469.5 6.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4693) BEN PF10523.7 001194221.1_29629001_2 - 0.11 12.6 0.4 1.3 9.2 0.0 2.7 2 0 0 2 2 2 0 BEN domain DUF4566 PF15130.4 001194185.1_29629001_3 - 2.8e-136 452.0 2.8 3.6e-136 451.6 2.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4566) PH PF00169.27 001172414.1_29629001_2 - 3.1e-17 62.9 2.1 7e-17 61.7 2.1 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 001172414.1_29629001_2 - 4.4e-05 23.7 3.9 0.0004 20.6 3.9 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain EF-hand_7 PF13499.4 001172414.1_29629001_2 - 0.0069 16.7 0.3 0.04 14.3 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.4 001172414.1_29629001_2 - 0.011 15.4 0.0 0.053 13.4 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.30 001172414.1_29629001_2 - 0.1 12.1 0.0 0.31 10.6 0.0 1.9 1 0 0 1 1 1 0 EF hand Peptidase_C2 PF00648.19 001193764.1_29629001_3 - 1.3e-10 40.6 2.1 6.5e-08 31.8 0.0 3.4 4 0 0 4 4 4 2 Calpain family cysteine protease Globin PF00042.20 001193764.1_29629001_3 - 0.0067 16.8 0.3 0.05 14.0 0.1 2.4 2 0 0 2 2 2 1 Globin IQ PF00612.25 001193764.1_29629001_3 - 0.013 15.1 0.4 0.047 13.4 0.4 2.0 1 0 0 1 1 1 0 IQ calmodulin-binding motif CARD_2 PF16739.3 001047123.2_29627001_1 - 1.1e-47 159.7 1.0 7.6e-23 80.2 0.8 2.8 2 0 0 2 2 2 2 Caspase recruitment domain RIG-I_C-RD PF11648.6 001047123.2_29627001_1 - 1.2e-37 128.7 6.1 1.2e-37 128.7 6.1 2.1 2 0 0 2 2 2 1 C-terminal domain of RIG-I ResIII PF04851.13 001047123.2_29627001_1 - 3.6e-21 75.8 0.1 2e-20 73.3 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.29 001047123.2_29627001_1 - 6.1e-21 74.7 1.9 5.1e-20 71.8 0.3 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.27 001047123.2_29627001_1 - 3.2e-19 69.2 0.0 1.1e-18 67.4 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase CARD PF00619.19 001047123.2_29627001_1 - 4.4e-14 52.2 1.6 2.4e-12 46.6 1.5 2.7 2 0 0 2 2 2 1 Caspase recruitment domain AAA_22 PF13401.4 001047123.2_29627001_1 - 0.003 17.7 0.2 0.042 14.0 0.0 2.9 2 1 0 2 2 2 1 AAA domain DUF3638 PF12340.6 001047123.2_29627001_1 - 0.012 14.8 0.0 0.029 13.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) AAA_19 PF13245.4 001047123.2_29627001_1 - 0.061 13.5 1.0 0.49 10.6 0.1 2.9 3 1 0 3 3 3 0 AAA domain PDEase_I PF00233.17 001278479.1_29626001_1 - 1.5e-80 270.2 5.3 2.8e-80 269.3 5.3 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.24 001278479.1_29626001_1 - 2.4e-24 86.2 0.0 4e-11 43.4 0.0 2.5 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.4 001278479.1_29626001_1 - 1.2e-09 38.5 0.0 0.00054 20.1 0.0 2.4 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.4 001278479.1_29626001_1 - 1.4e-06 28.5 0.0 0.0012 19.1 0.0 2.8 2 1 0 2 2 2 2 GAF domain SpoVT_C PF15714.3 001278479.1_29626001_1 - 1.5e-05 24.9 0.2 0.07 13.0 0.0 3.5 3 0 0 3 3 3 2 Stage V sporulation protein T C-terminal, transcription factor OB_NTP_bind PF07717.14 001278479.1_29626001_1 - 0.12 12.4 0.0 0.35 10.9 0.0 1.8 1 0 0 1 1 1 0 Oligonucleotide/oligosaccharide-binding (OB)-fold Ion_trans PF00520.29 001193822.1_29627001_2 - 2.4e-44 151.3 13.6 3.1e-44 150.9 13.6 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001193822.1_29627001_2 - 2e-27 95.2 0.0 4.4e-27 94.1 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 001193822.1_29627001_2 - 1.1e-10 41.2 2.7 1.1e-10 41.2 2.7 2.4 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.3 001193822.1_29627001_2 - 0.0088 16.0 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ras PF00071.20 001257646.1_29623001_2 - 3.5e-50 169.6 0.0 4.5e-50 169.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001257646.1_29623001_2 - 1.6e-32 112.2 0.1 2.3e-32 111.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001257646.1_29623001_2 - 7.9e-15 54.6 0.0 1e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001257646.1_29623001_2 - 4.8e-08 32.5 0.0 6.8e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001257646.1_29623001_2 - 6.5e-07 29.3 0.0 1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.8 001257646.1_29623001_2 - 1.6e-05 24.3 0.0 2.7e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.25 001257646.1_29623001_2 - 5.6e-05 22.6 0.9 0.0023 17.4 0.8 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain G-alpha PF00503.18 001257646.1_29623001_2 - 0.0012 17.9 0.8 0.0049 15.9 0.8 2.0 1 1 1 2 2 2 1 G-protein alpha subunit TniB PF05621.9 001257646.1_29623001_2 - 0.053 12.6 0.0 0.086 11.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.7 001257646.1_29623001_2 - 0.063 12.9 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation 7tm_4 PF13853.4 001168329.1_29622001_1 - 7.3e-49 166.8 21.6 8.5e-49 166.6 21.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001168329.1_29622001_1 - 5e-21 75.0 28.9 1.1e-20 73.9 28.9 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168329.1_29622001_1 - 0.00065 19.0 21.4 0.001 18.3 21.4 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TAS2R PF05296.11 001080758.2_29622001_1 - 2e-91 306.2 21.6 2.2e-91 306.0 21.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) MMR_HSR1 PF01926.21 001193688.1_29625001_3 - 5.7e-10 39.2 0.1 1e-08 35.2 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.21 001193688.1_29625001_3 - 0.00022 21.2 0.2 0.0039 17.1 0.1 2.7 2 1 0 2 2 2 1 Dynamin family DUF258 PF03193.14 001193688.1_29625001_3 - 0.0023 17.7 0.0 0.037 13.8 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 FeoB_N PF02421.16 001193688.1_29625001_3 - 0.025 14.0 0.0 0.063 12.7 0.0 1.7 1 0 0 1 1 1 0 Ferrous iron transport protein B Septin PF00735.16 001193688.1_29625001_3 - 0.033 13.3 0.0 0.22 10.6 0.0 2.1 2 0 0 2 2 2 0 Septin ABC_tran PF00005.25 001193688.1_29625001_3 - 0.083 13.3 0.1 0.21 12.0 0.0 1.8 2 0 0 2 2 2 0 ABC transporter GTP_EFTU PF00009.25 001193688.1_29625001_3 - 0.11 11.9 0.0 9.1 5.6 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain E7 PF00527.16 001193688.1_29625001_3 - 0.57 10.3 3.6 0.83 9.8 0.6 2.3 2 0 0 2 2 2 0 E7 protein, Early protein DNA_pol3_a_NII PF11490.6 001193688.1_29625001_3 - 1.8 8.3 6.1 4.5 7.1 6.1 1.6 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II DEK_C PF08766.9 001257528.1_29626001_3 - 8e-18 64.0 0.8 1.5e-17 63.1 0.8 1.5 1 0 0 1 1 1 1 DEK C terminal domain SAP PF02037.25 001257528.1_29626001_3 - 5.9e-06 25.8 0.1 1.9e-05 24.1 0.1 2.0 1 0 0 1 1 1 1 SAP domain DUF2052 PF09747.7 001257528.1_29626001_3 - 0.011 15.7 29.2 0.12 12.3 18.1 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) KTI12 PF08433.8 001261242.1_29624001_2 - 7.8e-108 359.9 0.0 9.3e-108 359.6 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.4 001261242.1_29624001_2 - 8.8e-05 22.6 0.0 0.00015 21.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.18 001261242.1_29624001_2 - 0.14 11.9 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase Ras PF00071.20 001194639.1_29627001_3 - 3e-22 78.8 0.0 5.7e-22 77.9 0.0 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.11 001194639.1_29627001_3 - 2.5e-05 24.4 0.0 0.00012 22.2 0.0 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.21 001194639.1_29627001_3 - 0.027 14.4 0.0 0.037 14.0 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.4 001194639.1_29627001_3 - 0.035 14.3 0.0 0.061 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.4 001194639.1_29627001_3 - 0.11 12.4 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain Arf PF00025.19 001194639.1_29627001_3 - 0.17 11.2 0.0 11 5.3 0.0 2.1 2 0 0 2 2 2 0 ADP-ribosylation factor family ATPase PF06745.11 001194639.1_29627001_3 - 0.26 10.5 0.0 0.39 9.9 0.0 1.1 1 0 0 1 1 1 0 KaiC TC1 PF15063.4 001266977.2_29623001_2 - 1.8e-28 98.1 0.1 3.2e-28 97.3 0.1 1.4 1 0 0 1 1 1 1 Thyroid cancer protein 1 Trypsin PF00089.24 001194456.1_29622001_1 - 1e-70 237.9 2.0 1.2e-70 237.7 2.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001194456.1_29622001_1 - 1.9e-05 25.4 0.2 2.8e-05 24.9 0.2 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001194456.1_29622001_1 - 3e-05 24.3 0.1 7.2e-05 23.0 0.1 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) DUF316 PF03761.13 001194456.1_29622001_1 - 0.062 12.7 0.0 0.16 11.4 0.0 1.7 2 0 0 2 2 2 0 Chymotrypsin family Peptidase-S1 ribosomal_L24 PF17136.2 001257844.1_29622001_2 - 1.1e-11 44.9 0.0 1.8e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.27 001257844.1_29622001_2 - 9.9e-07 28.4 1.7 2.2e-06 27.3 1.7 1.6 1 0 0 1 1 1 1 KOW motif ubiquitin PF00240.21 001193586.1_29622001_1 - 1.1e-34 117.9 0.3 1.9e-34 117.1 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.17 001193586.1_29622001_1 - 3.7e-28 97.3 4.2 7.7e-28 96.3 4.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.6 001193586.1_29622001_1 - 8.3e-17 60.7 0.4 1.6e-16 59.8 0.4 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 001193586.1_29622001_1 - 4.3e-06 26.9 0.7 3.2e-05 24.2 0.2 2.6 2 1 1 3 3 3 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 001193586.1_29622001_1 - 0.0002 21.3 0.7 0.00039 20.4 0.7 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001193586.1_29622001_1 - 0.0085 16.5 0.6 0.012 16.0 0.6 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain IBR PF01485.19 001193586.1_29622001_1 - 0.066 13.3 4.2 0.11 12.6 4.2 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain IL8 PF00048.18 001193507.1_29624001_1 - 0.00057 19.9 3.2 0.0013 18.8 3.2 1.6 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like DUF4604 PF15377.4 001193507.1_29624001_1 - 0.48 10.7 4.1 0.71 10.2 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) UPF0160 PF03690.11 001194260.1_29623001_1 - 2.4e-139 464.3 0.0 2.7e-139 464.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Complex1_30kDa PF00329.17 001194303.1_29622001_2 - 6.5e-45 152.6 0.0 8.8e-45 152.1 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 7tm_1 PF00001.19 001172747.1_09923001_2 - 2.9e-51 174.1 9.4 4e-51 173.7 9.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001172747.1_09923001_2 - 2.6e-08 33.5 12.1 2.2e-06 27.1 3.7 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001172747.1_09923001_2 - 0.0014 18.2 3.0 0.0024 17.5 2.3 1.7 2 0 0 2 2 2 1 Olfactory receptor Actin PF00022.17 001164650.1_49823001_2 - 8.2e-150 498.8 0.0 2.7e-149 497.1 0.0 1.6 1 1 0 1 1 1 1 Actin Sarcolipin PF05366.9 001044566.2_49823001_2 - 3.7e-22 77.6 5.7 6.2e-22 76.8 5.7 1.4 1 0 0 1 1 1 1 Sarcolipin Linker_histone PF00538.17 001205063.1_49823001_2 - 8.8e-21 73.9 0.0 1.9e-20 72.8 0.0 1.6 1 0 0 1 1 1 1 linker histone H1 and H5 family Ras PF00071.20 001243060.1_49828001_1 - 7.6e-64 214.1 0.2 1e-63 213.7 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001243060.1_49828001_1 - 5e-33 113.7 0.2 7.1e-33 113.3 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001243060.1_49828001_1 - 1e-13 51.0 0.1 1.5e-13 50.5 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001243060.1_49828001_1 - 0.00027 20.2 0.1 0.00037 19.8 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001243060.1_49828001_1 - 0.00045 19.7 0.0 0.00068 19.1 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.8 001243060.1_49828001_1 - 0.028 13.7 0.0 0.043 13.1 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 001243060.1_49828001_1 - 0.069 13.1 0.1 0.11 12.5 0.1 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase HlyIII PF03006.18 001007193.1_49823001_2 - 4e-73 245.7 19.8 4.9e-73 245.4 19.8 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF4405 PF14358.4 001007193.1_49823001_2 - 0.014 15.8 3.4 0.014 15.8 3.4 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4405) DUF962 PF06127.9 001007193.1_49823001_2 - 0.025 14.5 1.1 0.025 14.5 1.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF962) TGFb_propeptide PF00688.16 001105290.1_49823001_1 - 5.6e-84 281.6 0.1 7e-84 281.3 0.1 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001105290.1_49823001_1 - 1.4e-36 125.4 0.7 2.7e-36 124.5 0.7 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain Ribosomal_L7Ae PF01248.24 001190178.1_49822001_2 - 9.7e-26 89.2 0.1 1.3e-25 88.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Hydrolase_6 PF13344.4 001190178.1_49822001_2 - 0.053 13.5 0.0 0.073 13.1 0.0 1.3 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DHO_dh PF01180.19 214044.2_49829001_3 - 1.7e-35 122.6 0.0 6.5e-35 120.6 0.0 1.9 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase Fer4_20 PF14691.4 214044.2_49829001_3 - 1.8e-31 108.1 0.1 1.8e-31 108.1 0.1 2.1 3 0 0 3 3 2 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_21 PF14697.4 214044.2_49829001_3 - 2.6e-23 81.8 13.2 2.6e-23 81.8 13.2 3.8 4 1 0 4 4 4 1 4Fe-4S dicluster domain Pyr_redox_2 PF07992.12 214044.2_49829001_3 - 1.1e-13 51.0 0.0 1.8e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 214044.2_49829001_3 - 1.7e-07 31.2 0.0 3.8e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Dus PF01207.15 214044.2_49829001_3 - 1.1e-05 24.5 0.0 5.7e-05 22.2 0.0 1.9 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) Pyr_redox_3 PF13738.4 214044.2_49829001_3 - 1.4e-05 24.4 0.0 0.059 12.5 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Fer4_10 PF13237.4 214044.2_49829001_3 - 4.9e-05 23.2 29.0 0.00019 21.3 10.8 3.3 3 1 0 3 3 3 2 4Fe-4S dicluster domain Fer4_7 PF12838.5 214044.2_49829001_3 - 5.1e-05 23.7 10.1 5.1e-05 23.7 10.1 4.0 3 1 0 3 3 2 1 4Fe-4S dicluster domain Fer4_2 PF12797.5 214044.2_49829001_3 - 0.0001 22.0 31.2 0.0035 17.2 3.0 4.7 4 0 0 4 4 4 2 4Fe-4S binding domain Pyr_redox PF00070.25 214044.2_49829001_3 - 0.00016 22.1 0.0 1 9.9 0.0 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Fer4_6 PF12837.5 214044.2_49829001_3 - 0.0002 21.2 2.6 0.0002 21.2 2.6 4.5 4 0 0 4 4 3 2 4Fe-4S binding domain Fer4_9 PF13187.4 214044.2_49829001_3 - 0.0068 16.4 12.0 0.0068 16.4 12.0 3.3 2 1 1 3 3 3 1 4Fe-4S dicluster domain Fer4 PF00037.25 214044.2_49829001_3 - 0.0071 16.0 5.9 0.0071 16.0 5.9 4.7 6 0 0 6 6 5 2 4Fe-4S binding domain Fer4_8 PF13183.4 214044.2_49829001_3 - 0.27 11.6 21.7 0.31 11.4 2.2 3.8 2 1 1 3 3 3 0 4Fe-4S dicluster domain EF-hand_8 PF13833.4 001244142.1_49824001_3 - 1.8e-14 53.1 0.2 1e-08 34.6 0.1 3.2 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.30 001244142.1_49824001_3 - 4.3e-14 50.8 0.1 0.0032 16.8 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.4 001244142.1_49824001_3 - 1.6e-12 46.1 0.1 0.0001 21.8 0.0 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.4 001244142.1_49824001_3 - 1.2e-11 44.7 0.0 1.1e-05 25.7 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 001244142.1_49824001_3 - 1.5e-08 33.6 0.2 0.0037 16.6 0.0 3.7 4 0 0 4 4 4 2 EF hand TerB PF05099.11 001244142.1_49824001_3 - 0.12 12.2 0.0 13 5.6 0.0 2.1 2 0 0 2 2 2 0 Tellurite resistance protein TerB BST2 PF16716.3 001178051.1_39522001_1 - 8.8e-28 96.6 14.7 1.2e-27 96.2 14.7 1.1 1 0 0 1 1 1 1 Bone marrow stromal antigen 2 IncA PF04156.12 001178051.1_39522001_1 - 1.6e-05 24.7 7.5 2.5e-05 24.0 7.5 1.2 1 0 0 1 1 1 1 IncA protein HemX PF04375.12 001178051.1_39522001_1 - 0.00025 20.3 4.3 0.00031 20.0 4.3 1.1 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase OmpH PF03938.12 001178051.1_39522001_1 - 0.00028 20.8 1.8 0.0004 20.3 1.8 1.2 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) VPS28 PF03997.10 001178051.1_39522001_1 - 0.002 17.7 0.5 0.0026 17.4 0.5 1.2 1 0 0 1 1 1 1 VPS28 protein DUF3450 PF11932.6 001178051.1_39522001_1 - 0.0025 17.0 3.9 0.0032 16.7 3.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) TMPIT PF07851.11 001178051.1_39522001_1 - 0.0029 16.8 2.1 0.0034 16.5 2.1 1.1 1 0 0 1 1 1 1 TMPIT-like protein Exonuc_VII_L PF02601.13 001178051.1_39522001_1 - 0.0038 16.7 1.5 0.0045 16.5 1.5 1.0 1 0 0 1 1 1 1 Exonuclease VII, large subunit DUF4200 PF13863.4 001178051.1_39522001_1 - 0.004 17.4 6.5 0.0057 16.9 6.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) DUF1049 PF06305.9 001178051.1_39522001_1 - 0.0045 16.6 0.2 0.0045 16.6 0.2 3.1 3 1 0 3 3 3 1 Protein of unknown function (DUF1049) MCPsignal PF00015.19 001178051.1_39522001_1 - 0.0046 16.6 0.8 0.0057 16.3 0.8 1.1 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Tropomyosin PF00261.18 001178051.1_39522001_1 - 0.0058 15.9 9.9 0.0084 15.4 9.9 1.2 1 0 0 1 1 1 1 Tropomyosin AI-2E_transport PF01594.14 001178051.1_39522001_1 - 0.0058 15.7 0.0 0.042 12.9 0.0 1.9 1 1 0 1 1 1 1 AI-2E family transporter Golgin_A5 PF09787.7 001178051.1_39522001_1 - 0.0073 15.7 9.2 0.0097 15.3 9.2 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 Spc7 PF08317.9 001178051.1_39522001_1 - 0.0081 14.9 10.1 0.01 14.6 10.1 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF948 PF06103.9 001178051.1_39522001_1 - 0.014 15.5 2.1 0.37 11.0 2.1 2.2 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) SlyX PF04102.10 001178051.1_39522001_1 - 0.015 15.7 3.9 0.015 15.7 3.9 2.1 1 1 1 2 2 2 0 SlyX DUF641 PF04859.10 001178051.1_39522001_1 - 0.016 15.4 4.5 0.023 14.9 4.5 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF1664 PF07889.10 001178051.1_39522001_1 - 0.029 14.2 3.1 0.044 13.6 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF489 PF04356.10 001178051.1_39522001_1 - 0.03 14.2 0.6 0.037 13.9 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF489) Filament PF00038.19 001178051.1_39522001_1 - 0.03 13.8 7.2 0.041 13.3 7.2 1.1 1 0 0 1 1 1 0 Intermediate filament protein DUF342 PF03961.11 001178051.1_39522001_1 - 0.031 12.8 0.3 0.035 12.6 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Atg14 PF10186.7 001178051.1_39522001_1 - 0.037 13.0 5.9 0.049 12.6 5.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CENP-F_leu_zip PF10473.7 001178051.1_39522001_1 - 0.044 13.7 10.7 0.14 12.1 10.9 1.5 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.9 001178051.1_39522001_1 - 0.045 13.8 13.1 0.088 12.8 13.1 1.4 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Bap31 PF05529.10 001178051.1_39522001_1 - 0.047 13.2 3.8 0.069 12.6 3.8 1.3 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like DUF4381 PF14316.4 001178051.1_39522001_1 - 0.047 13.8 0.7 0.07 13.2 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Bacillus_HBL PF05791.9 001178051.1_39522001_1 - 0.05 13.2 1.9 0.072 12.7 1.9 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) AAA_13 PF13166.4 001178051.1_39522001_1 - 0.098 11.2 3.5 0.12 10.9 3.5 1.1 1 0 0 1 1 1 0 AAA domain DUF4713 PF15831.3 001178051.1_39522001_1 - 0.11 12.9 0.0 0.31 11.4 0.0 1.9 2 0 0 2 2 1 0 Domain of unknown function (DUF4713) MbeD_MobD PF04899.10 001178051.1_39522001_1 - 0.11 12.5 5.9 0.25 11.3 5.9 1.7 1 1 0 1 1 1 0 MbeD/MobD like Phage_GP20 PF06810.9 001178051.1_39522001_1 - 0.11 12.2 8.4 0.13 11.9 7.0 1.7 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF4446 PF14584.4 001178051.1_39522001_1 - 0.12 12.3 2.1 1.9 8.3 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF2064 PF09837.7 001178051.1_39522001_1 - 0.12 12.1 0.7 0.19 11.4 0.5 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) HrpB7 PF09486.8 001178051.1_39522001_1 - 0.16 12.2 8.7 0.34 11.2 8.7 1.6 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) V_ATPase_I PF01496.17 001178051.1_39522001_1 - 0.16 9.7 1.0 0.17 9.6 1.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GrpE PF01025.17 001178051.1_39522001_1 - 0.17 11.4 9.3 2.1 7.9 9.3 2.0 1 1 0 1 1 1 0 GrpE NYD-SP28 PF14772.4 001178051.1_39522001_1 - 0.28 11.1 11.8 0.57 10.1 6.4 2.3 1 1 1 2 2 2 0 Sperm tail Bcr-Abl_Oligo PF09036.8 001178051.1_39522001_1 - 0.29 11.0 5.1 0.44 10.4 0.4 2.2 1 1 1 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain ADIP PF11559.6 001178051.1_39522001_1 - 0.33 10.9 11.7 0.76 9.7 11.8 1.5 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding Sec2p PF06428.9 001178051.1_39522001_1 - 0.36 10.7 12.1 2.4 8.0 4.2 2.2 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p APG6 PF04111.10 001178051.1_39522001_1 - 0.56 9.4 8.6 0.74 9.0 8.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4407 PF14362.4 001178051.1_39522001_1 - 0.64 9.2 8.0 0.94 8.6 8.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Snapin_Pallidin PF14712.4 001178051.1_39522001_1 - 0.77 10.1 10.0 0.12 12.7 3.0 2.1 1 1 1 2 2 2 0 Snapin/Pallidin DUF3373 PF11853.6 001178051.1_39522001_1 - 0.95 8.0 3.5 0.61 8.6 1.6 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3373) ABC_tran_CTD PF16326.3 001178051.1_39522001_1 - 1.1 9.4 6.6 2.2 8.5 6.2 1.7 1 1 0 1 1 1 0 ABC transporter C-terminal domain Seryl_tRNA_N PF02403.20 001178051.1_39522001_1 - 1.2 9.2 8.0 0.86 9.7 6.0 1.7 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain NPV_P10 PF05531.10 001178051.1_39522001_1 - 1.3 9.5 6.0 2.3 8.6 2.4 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Cluap1 PF10234.7 001178051.1_39522001_1 - 1.5 8.0 9.6 3.7 6.7 9.7 1.5 1 1 0 1 1 1 0 Clusterin-associated protein-1 Swi5 PF07061.9 001178051.1_39522001_1 - 1.9 8.5 7.4 2.2 8.2 0.2 2.2 2 0 0 2 2 2 0 Swi5 Mnd1 PF03962.13 001178051.1_39522001_1 - 2.1 8.0 10.2 11 5.7 10.4 1.8 1 1 0 1 1 1 0 Mnd1 family Rho_Binding PF08912.9 001178051.1_39522001_1 - 2.6 8.8 13.0 2.1 9.1 2.1 2.2 1 1 1 2 2 2 0 Rho Binding DUF2570 PF10828.6 001178051.1_39522001_1 - 2.7 7.8 11.2 2.1 8.1 2.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) Cnn_1N PF07989.9 001178051.1_39522001_1 - 3.4 7.7 10.0 12 6.0 4.5 2.4 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Spc24 PF08286.9 001178051.1_39522001_1 - 4 7.6 10.4 0.47 10.6 2.6 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF2076 PF09849.7 001178051.1_39522001_1 - 5.3 6.9 9.6 0.099 12.5 1.3 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) EF-hand_8 PF13833.4 001244143.1_49824001_1 - 1.8e-14 53.1 0.2 1e-08 34.6 0.1 3.2 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.30 001244143.1_49824001_1 - 4.2e-14 50.8 0.1 0.0032 16.8 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.4 001244143.1_49824001_1 - 1.6e-12 46.1 0.1 0.0001 21.8 0.0 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.4 001244143.1_49824001_1 - 1.2e-11 44.7 0.0 1.1e-05 25.7 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 001244143.1_49824001_1 - 1.5e-08 33.6 0.2 0.0037 16.6 0.0 3.7 4 0 0 4 4 4 2 EF hand TerB PF05099.11 001244143.1_49824001_1 - 0.095 12.5 0.0 13 5.6 0.0 2.1 2 0 0 2 2 2 0 Tellurite resistance protein TerB Lipocalin PF00061.21 001114667.1_39521001_1 - 4.2e-28 98.2 0.7 4.6e-28 98.1 0.7 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001114667.1_39521001_1 - 5.4e-07 29.5 1.0 6.9e-07 29.1 1.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family PPARgamma_N PF12577.6 001100921.1_39523001_1 - 4.8e-32 110.3 1.1 1.2e-31 109.0 1.1 1.7 1 0 0 1 1 1 1 PPAR gamma N-terminal region zf-C4 PF00105.16 001100921.1_39523001_1 - 1.6e-27 95.6 15.0 2.6e-27 94.9 15.0 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001100921.1_39523001_1 - 6.8e-17 61.6 0.1 1.8e-16 60.2 0.1 1.7 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Tmemb_55A PF09788.7 001100921.1_39523001_1 - 0.02 13.8 3.3 0.032 13.2 3.3 1.2 1 0 0 1 1 1 0 Transmembrane protein 55A WW PF00397.24 001246668.1_49822001_2 - 4.1e-06 26.5 0.5 7.5e-06 25.7 0.5 1.5 1 0 0 1 1 1 1 WW domain MIP-T3 PF10243.7 001246668.1_49822001_2 - 2.4 6.6 29.2 2.6 6.5 29.2 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Ureide_permease PF07168.9 001246668.1_49822001_2 - 3.3 6.3 4.1 4.3 5.9 4.1 1.1 1 0 0 1 1 1 0 Ureide permease CybS PF05328.10 001078653.1_39521001_1 - 1.3e-24 86.2 0.2 1.6e-24 86.0 0.2 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Tetraspannin PF00335.18 001243865.1_49824001_3 - 1.4e-48 165.3 10.9 1.8e-48 165.0 10.9 1.1 1 0 0 1 1 1 1 Tetraspanin family CD20 PF04103.13 001243865.1_49824001_3 - 2.3e-07 30.9 0.5 4.3e-07 30.0 0.5 1.5 1 0 0 1 1 1 1 CD20-like family DUF4199 PF13858.4 001243865.1_49824001_3 - 0.0021 18.4 0.7 0.0036 17.6 0.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4199) SUR7 PF06687.10 001243865.1_49824001_3 - 0.016 14.8 6.0 0.034 13.6 6.0 1.6 1 0 0 1 1 1 0 SUR7/PalI family DUF2569 PF10754.7 001243865.1_49824001_3 - 0.44 10.8 6.8 0.77 10.1 6.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) Baculo_11_kDa PF06143.9 001243865.1_49824001_3 - 0.68 9.4 5.0 11 5.6 0.1 2.9 3 0 0 3 3 3 0 Baculovirus 11 kDa family DUF308 PF03729.11 001243865.1_49824001_3 - 5.8 7.2 18.1 0.28 11.4 7.0 2.6 1 1 1 2 2 2 0 Short repeat of unknown function (DUF308) CRF PF00473.15 001040679.1_22422001_1 - 2e-16 59.7 1.1 3.8e-16 58.8 1.1 1.5 1 0 0 1 1 1 1 Corticotropin-releasing factor family Y_phosphatase PF00102.25 001244341.1_49822001_2 - 1.2e-07 31.5 0.0 2.3e-07 30.5 0.0 1.5 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 001244341.1_49822001_2 - 6.7e-07 29.0 0.0 9.3e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.10 001244341.1_49822001_2 - 0.076 12.5 0.0 0.25 10.8 0.0 1.7 1 1 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Tetraspannin PF00335.18 001243860.1_49823001_3 - 1e-44 152.7 10.6 1.4e-44 152.3 10.6 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF3185 PF11381.6 001243860.1_49823001_3 - 7 6.6 8.2 18 5.3 0.5 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3185) 7tm_1 PF00001.19 001082693.1_37923001_1 - 1e-69 234.6 0.0 1.3e-69 234.3 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001082693.1_37923001_1 - 1.9e-07 31.0 9.2 3.3e-06 26.9 2.8 2.3 3 0 0 3 3 3 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001082693.1_37923001_1 - 1.5e-06 27.7 17.6 2.7e-06 26.8 3.3 2.5 3 0 0 3 3 3 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001082693.1_37923001_1 - 0.00016 21.0 6.4 0.00016 21.0 6.4 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF4727 PF15856.3 001082693.1_37923001_1 - 0.065 12.7 0.3 0.76 9.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4727) TGFb_propeptide PF00688.16 001110277.1_39523001_3 - 1.1e-52 179.2 0.2 1.6e-52 178.6 0.2 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001110277.1_39523001_3 - 1.1e-33 116.1 0.5 2.1e-33 115.2 0.5 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain Tnp_DNA_bind PF14706.4 001110277.1_39523001_3 - 0.017 14.8 0.1 2.6 7.8 0.0 2.7 2 0 0 2 2 2 0 Transposase DNA-binding ig PF00047.23 024330.1_26225120_1 - 0.12 12.4 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain SUZ PF12752.5 102345.1_45727120_1 - 1.2e-12 48.3 0.2 3.9e-12 46.6 0.2 2.0 1 0 0 1 1 1 1 SUZ domain SUZ-C PF12901.5 102345.1_45727120_1 - 7.8e-09 35.3 2.1 1.7e-08 34.2 2.1 1.6 1 0 0 1 1 1 1 SUZ-C motif CAP_N PF01213.17 102345.1_45727120_2 - 4.8 6.4 7.1 9.8 5.4 7.1 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Maf PF02545.12 015551.1_32923120_1 - 0.18 11.5 0.8 0.94 9.2 0.1 2.3 2 1 0 2 2 2 0 Maf-like protein Fe_hyd_lg_C PF02906.12 001204755.1_29625001_2 - 4.7e-76 255.5 0.0 6.6e-76 255.1 0.0 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Fe_hyd_SSU PF02256.15 001204755.1_29625001_2 - 1.6e-05 24.7 0.0 3.5e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Iron hydrogenase small subunit FAD_syn PF06574.10 001204755.1_29625001_2 - 0.12 12.1 0.4 0.22 11.3 0.4 1.3 1 0 0 1 1 1 0 FAD synthetase DUF1358 PF07096.9 001185165.1_49822001_2 - 7.3e-55 183.7 0.9 1e-54 183.3 0.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1358) TNFR_c6 PF00020.16 001278763.1_49822001_1 - 3.6e-07 30.3 18.4 1.9e-06 28.1 7.6 4.2 3 1 0 4 4 4 2 TNFR/NGFR cysteine-rich region FGF PF00167.16 001246263.2_39524001_1 - 1.3e-42 144.7 0.1 1.9e-42 144.1 0.1 1.3 1 0 0 1 1 1 1 Fibroblast growth factor PRIMA1 PF16101.3 001246263.2_39524001_2 - 1.3 8.9 8.0 1.8 8.5 2.8 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Aa_trans PF01490.16 001192009.1_45723001_1 - 8.4e-56 189.3 21.0 1.1e-55 188.9 21.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.11 001192009.1_45723001_1 - 7.5e-07 28.4 9.4 7.5e-07 28.4 9.4 2.4 2 1 1 3 3 3 1 Tryptophan/tyrosine permease family 7tm_4 PF13853.4 001000438.1_45722001_1 - 5.4e-50 170.6 23.7 7.2e-50 170.1 23.7 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001000438.1_45722001_1 - 2.3e-24 85.9 25.4 4.4e-24 85.0 25.4 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001000438.1_45722001_1 - 0.00036 19.9 26.1 0.00049 19.4 26.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Orn_Arg_deC_N PF02784.14 001294156.2_37925001_1 - 2.4e-67 226.8 0.0 3.1e-67 226.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001294156.2_37925001_1 - 6.6e-19 67.9 0.0 1.2e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 001294156.2_37925001_1 - 0.00066 19.0 0.0 0.0014 18.0 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel ApoL PF05461.9 001302101.1_40423001_1 - 1.3e-101 339.9 6.6 5.1e-80 269.0 0.3 2.1 1 1 1 2 2 2 2 Apolipoprotein L GIT_CC PF16559.3 001302101.1_40423001_1 - 0.02 14.8 5.3 0.55 10.2 0.1 3.0 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor COG5 PF10392.7 001302101.1_40423001_1 - 0.024 14.7 1.7 4.1 7.5 0.0 2.7 2 1 0 2 2 2 0 Golgi transport complex subunit 5 FlxA PF14282.4 001302101.1_40423001_1 - 0.029 14.2 0.3 0.063 13.1 0.3 1.6 1 0 0 1 1 1 0 FlxA-like protein DUF573 PF04504.12 001302101.1_40423001_1 - 0.095 13.2 3.3 4.2 8.0 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function, DUF573 BLOC1_2 PF10046.7 001302101.1_40423001_1 - 0.13 12.4 5.5 1 9.6 0.7 3.1 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF668 PF05003.10 001302101.1_40423001_1 - 0.55 10.6 2.8 5.5 7.4 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF668) CLZ PF16526.3 001302101.1_40423001_1 - 0.68 10.2 7.9 1.6 9.0 1.0 3.0 3 0 0 3 3 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF883 PF05957.11 001302101.1_40423001_1 - 0.97 9.9 8.2 21 5.7 0.5 4.0 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) Syntaxin-6_N PF09177.9 001302101.1_40423001_1 - 1 9.8 6.0 3.3 8.2 0.2 3.6 3 2 0 3 3 3 0 Syntaxin 6, N-terminal Cor1 PF04803.10 001302101.1_40423001_1 - 3 7.9 8.4 0.47 10.5 1.3 2.4 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region Ald_Xan_dh_C2 PF02738.16 001302102.1_40429001_1 - 1.7e-186 620.8 0.0 2.1e-186 620.5 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001302102.1_40429001_1 - 1.3e-45 155.1 0.0 2.5e-45 154.1 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Fer2_2 PF01799.18 001302102.1_40429001_1 - 5.7e-31 106.2 0.8 1.8e-30 104.6 0.8 1.9 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 001302102.1_40429001_1 - 2.9e-28 97.9 0.0 8.4e-28 96.4 0.0 1.9 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Ald_Xan_dh_C PF01315.20 001302102.1_40429001_1 - 3.3e-28 98.1 0.0 6.6e-28 97.1 0.0 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2 PF00111.25 001302102.1_40429001_1 - 7.7e-09 35.3 3.5 2.4e-08 33.7 0.1 3.0 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Asp_protease_2 PF13650.4 001292090.2_37929001_1 - 0.001 19.5 0.1 0.0025 18.3 0.0 1.6 2 0 0 2 2 2 1 Aspartyl protease RVP_2 PF08284.9 001292090.2_37929001_1 - 0.019 14.9 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001292090.2_37929001_1 - 0.044 14.2 0.0 0.08 13.4 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF4939 PF16297.3 001292090.2_37929001_2 - 1.8e-15 56.6 0.0 3.3e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.15 001292090.2_37929001_2 - 2.9e-15 56.2 2.2 7.3e-15 54.9 0.1 2.3 2 0 0 2 2 2 1 Retrotransposon gag protein zf-CCHC_5 PF14787.4 001292090.2_37929001_2 - 0.0026 17.3 0.2 0.0063 16.1 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger KASH_CCD PF14662.4 001292090.2_37929001_2 - 0.004 16.9 4.9 0.0066 16.2 4.9 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH IncA PF04156.12 001292090.2_37929001_2 - 0.035 13.7 4.7 0.09 12.4 4.7 1.6 1 0 0 1 1 1 0 IncA protein Spc29 PF17082.3 001292090.2_37929001_2 - 0.04 13.6 0.4 0.069 12.9 0.4 1.2 1 0 0 1 1 1 0 Spindle Pole Component 29 SlyX PF04102.10 001292090.2_37929001_2 - 0.045 14.2 3.1 0.15 12.6 3.1 1.9 1 0 0 1 1 1 0 SlyX CCDC106 PF15794.3 001292090.2_37929001_2 - 0.049 13.2 0.6 0.094 12.3 0.6 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 CASP_C PF08172.10 001292090.2_37929001_2 - 0.061 12.5 0.1 0.42 9.8 0.0 1.9 2 0 0 2 2 2 0 CASP C terminal ZapB PF06005.10 001292090.2_37929001_2 - 0.26 11.6 10.8 0.59 10.5 10.8 1.5 1 0 0 1 1 1 0 Cell division protein ZapB Rootletin PF15035.4 001292090.2_37929001_2 - 0.46 10.4 9.3 0.81 9.6 9.3 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF972 PF06156.11 001292090.2_37929001_2 - 0.66 10.5 3.9 1.6 9.3 3.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) GIT_CC PF16559.3 001292090.2_37929001_2 - 0.95 9.4 6.2 2.6 8.0 6.2 1.7 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Uso1_p115_C PF04871.11 001292090.2_37929001_2 - 0.99 9.7 9.4 1.6 8.9 9.4 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region CENP-H PF05837.10 001292090.2_37929001_2 - 1.1 9.6 7.8 2.2 8.6 7.8 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ERM PF00769.17 001292090.2_37929001_2 - 1.4 8.5 11.8 2.5 7.7 11.8 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DivIC PF04977.13 001292090.2_37929001_2 - 1.6 8.4 6.5 3.8 7.2 6.5 1.6 1 0 0 1 1 1 0 Septum formation initiator TBPIP PF07106.11 001292090.2_37929001_2 - 2.4 7.8 7.2 1 9.0 4.7 1.5 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TSC22 PF01166.16 001292090.2_37929001_2 - 8.4 6.7 6.2 45 4.3 6.2 2.0 1 1 0 1 1 1 0 TSC-22/dip/bun family DUF4939 PF16297.3 001302484.1_37929001_1 - 1.8e-15 56.6 0.0 3.3e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.15 001302484.1_37929001_1 - 2.9e-15 56.2 2.2 7.3e-15 54.9 0.1 2.3 2 0 0 2 2 2 1 Retrotransposon gag protein zf-CCHC_5 PF14787.4 001302484.1_37929001_1 - 0.0025 17.3 0.2 0.0063 16.1 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger KASH_CCD PF14662.4 001302484.1_37929001_1 - 0.004 16.9 4.9 0.0067 16.2 4.9 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH Spc29 PF17082.3 001302484.1_37929001_1 - 0.04 13.6 0.4 0.069 12.9 0.4 1.2 1 0 0 1 1 1 0 Spindle Pole Component 29 SlyX PF04102.10 001302484.1_37929001_1 - 0.047 14.2 3.1 0.15 12.6 3.1 1.8 1 0 0 1 1 1 0 SlyX CCDC106 PF15794.3 001302484.1_37929001_1 - 0.048 13.2 0.6 0.094 12.3 0.6 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 CASP_C PF08172.10 001302484.1_37929001_1 - 0.06 12.5 0.1 0.41 9.8 0.0 1.9 2 0 0 2 2 2 0 CASP C terminal IncA PF04156.12 001302484.1_37929001_1 - 0.12 12.1 6.4 0.29 10.8 6.4 1.6 1 0 0 1 1 1 0 IncA protein ZapB PF06005.10 001302484.1_37929001_1 - 0.26 11.6 10.8 0.6 10.5 10.8 1.5 1 0 0 1 1 1 0 Cell division protein ZapB Rootletin PF15035.4 001302484.1_37929001_1 - 0.45 10.4 9.3 0.81 9.6 9.3 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF972 PF06156.11 001302484.1_37929001_1 - 0.66 10.5 3.9 1.6 9.3 3.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) GIT_CC PF16559.3 001302484.1_37929001_1 - 0.95 9.4 6.2 2.6 8.0 6.2 1.7 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Uso1_p115_C PF04871.11 001302484.1_37929001_1 - 0.99 9.7 9.4 1.6 8.9 9.4 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region CENP-H PF05837.10 001302484.1_37929001_1 - 1.1 9.6 7.8 2.2 8.6 7.8 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ERM PF00769.17 001302484.1_37929001_1 - 1.4 8.5 11.8 2.5 7.7 11.8 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DivIC PF04977.13 001302484.1_37929001_1 - 1.6 8.4 6.5 3.8 7.2 6.5 1.6 1 0 0 1 1 1 0 Septum formation initiator TBPIP PF07106.11 001302484.1_37929001_1 - 2.4 7.8 7.2 1 9.0 4.7 1.5 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TSC22 PF01166.16 001302484.1_37929001_1 - 8.5 6.6 6.2 45 4.3 6.2 2.0 1 1 0 1 1 1 0 TSC-22/dip/bun family Asp_protease_2 PF13650.4 001302484.1_37929001_3 - 0.0011 19.5 0.1 0.0025 18.3 0.0 1.6 2 0 0 2 2 2 1 Aspartyl protease RVP_2 PF08284.9 001302484.1_37929001_3 - 0.019 14.8 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001302484.1_37929001_3 - 0.044 14.2 0.0 0.081 13.4 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-H2C2_2 PF13465.4 073391.1_26226120_1 - 5.2e-93 301.5 146.5 2.8e-07 30.5 0.3 19.2 19 0 0 19 19 19 16 Zinc-finger double domain zf-C2H2 PF00096.24 073391.1_26226120_1 - 3.6e-59 193.9 121.7 7.2e-06 26.0 2.2 19.1 19 0 0 19 19 19 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 073391.1_26226120_1 - 7.1e-31 104.1 116.3 0.0076 16.9 1.9 18.5 18 0 0 18 18 18 14 C2H2-type zinc finger zf-C2H2_6 PF13912.4 073391.1_26226120_1 - 1.6e-18 66.1 118.2 0.0019 18.0 0.9 17.9 18 0 0 18 18 17 14 C2H2-type zinc finger XPA_N PF01286.16 073391.1_26226120_1 - 2.3e-14 53.0 79.8 0.55 10.2 0.1 17.3 17 0 0 17 17 17 10 XPA protein N-terminal Zn-ribbon_8 PF09723.8 073391.1_26226120_1 - 2.3e-14 53.1 99.7 0.025 14.6 3.9 13.8 8 4 9 17 17 17 12 Zinc ribbon domain zf-C2H2_11 PF16622.3 073391.1_26226120_1 - 0.00061 19.3 66.2 2.6 7.7 1.0 15.9 16 0 0 16 16 16 5 zinc-finger C2H2-type BolA PF01722.16 073391.1_26226120_1 - 0.00062 19.9 25.9 6.1 7.1 0.0 8.7 6 2 2 9 9 9 1 BolA-like protein zf-C2H2_jaz PF12171.6 073391.1_26226120_1 - 0.0029 17.7 91.7 0.053 13.7 0.1 16.7 17 0 0 17 17 16 3 Zinc-finger double-stranded RNA-binding MRP-S23 PF10484.7 073391.1_26226120_1 - 0.029 14.5 0.5 1.1e+02 2.9 0.0 5.8 4 2 3 7 7 7 0 Mitochondrial ribosomal protein S23 Zf_RING PF16744.3 073391.1_26226120_1 - 0.23 11.5 0.1 0.23 11.5 0.1 12.0 4 4 8 13 13 13 0 KIAA1045 RING finger zinc_ribbon_15 PF17032.3 073391.1_26226120_1 - 0.98 10.1 83.3 0.45 11.2 4.2 9.7 3 1 3 9 9 8 0 zinc-ribbon family ADK_lid PF05191.12 073391.1_26226120_1 - 2.4 8.1 68.3 0.14 12.1 2.6 10.8 3 1 11 14 14 14 0 Adenylate kinase, active site lid GAGA PF09237.9 073391.1_26226120_1 - 4.9 6.9 20.2 3.6 7.3 0.0 6.4 4 2 4 8 8 8 0 GAGA factor KRAB PF01352.25 073391.1_26226120_2 - 2.7e-22 78.0 0.5 8.5e-22 76.4 0.5 1.9 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 073391.1_26226120_3 - 0.0014 18.9 0.0 0.0014 18.9 0.0 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-H2C2_2 PF13465.4 110193.1_26225120_2 - 3.6e-33 112.4 54.6 1.2e-07 31.7 1.8 7.8 8 0 0 8 8 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 110193.1_26225120_2 - 1.6e-26 91.1 55.1 8.1e-07 29.0 0.4 8.3 8 0 0 8 8 8 6 Zinc finger, C2H2 type KRAB PF01352.25 110193.1_26225120_2 - 9.9e-23 79.4 0.0 1.6e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 110193.1_26225120_2 - 9.8e-14 50.7 59.9 0.0094 16.6 0.4 8.9 9 0 0 9 9 9 7 C2H2-type zinc finger CpXC PF14353.4 110193.1_26225120_2 - 0.038 13.9 22.4 1.8 8.5 0.1 7.0 2 1 5 7 7 7 0 CpXC protein zf-LYAR PF08790.9 110193.1_26225120_2 - 0.039 13.7 21.9 1.2 9.0 0.1 5.7 6 0 0 6 6 6 0 LYAR-type C2HC zinc finger BolA PF01722.16 110193.1_26225120_2 - 0.051 13.7 3.3 0.79 9.9 0.2 3.0 2 1 1 3 3 3 0 BolA-like protein DNA_RNApol_7kD PF03604.11 110193.1_26225120_2 - 0.26 10.8 24.5 2.4 7.7 0.0 7.2 7 0 0 7 7 7 0 DNA directed RNA polymerase, 7 kDa subunit DYW_deaminase PF14432.4 110193.1_26225120_2 - 0.82 9.4 4.5 4.3 7.1 0.2 2.9 3 1 0 3 3 3 0 DYW family of nucleic acid deaminases zf-C2H2_jaz PF12171.6 110193.1_26225120_2 - 1.1 9.5 25.0 1.4 9.2 1.8 6.1 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 110193.1_26225120_2 - 2.2 8.4 39.4 0.46 10.5 2.4 6.0 4 1 4 8 8 8 0 Zinc ribbon domain zinc_ribbon_15 PF17032.3 110193.1_26225120_2 - 3.5 8.3 21.6 3 8.5 0.8 4.4 1 1 2 3 3 3 0 zinc-ribbon family zf-DNA_Pol PF08996.8 110193.1_26225120_2 - 5.3 6.6 16.0 3.5 7.2 4.5 3.2 1 1 3 4 4 4 0 DNA Polymerase alpha zinc finger DUF3268 PF11672.6 110193.1_26225120_2 - 5.6 7.2 16.8 1.4 9.1 0.6 3.6 1 1 5 6 6 6 0 zinc-finger-containing domain C1_4 PF07975.10 110193.1_26225120_2 - 8 6.7 25.5 2.8 8.2 0.9 5.4 2 2 4 6 6 6 0 TFIIH C1-like domain RBM1CTR PF08081.9 001318183.1_29623001_2 - 9e-13 47.9 3.3 1.5e-12 47.2 3.3 1.3 1 0 0 1 1 1 1 RBM1CTR (NUC064) family RRM_1 PF00076.20 001318183.1_29623001_3 - 2.2e-22 78.5 0.1 3.8e-22 77.8 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001318183.1_29623001_3 - 0.022 14.5 0.0 0.043 13.6 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_5 PF13893.4 001318183.1_29623001_3 - 0.037 13.5 0.0 0.077 12.5 0.0 1.4 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 001318183.1_29623001_3 - 0.11 12.4 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 Limkain b1 SpoIIIAC PF06686.9 001318183.1_29623001_3 - 0.17 12.0 0.2 0.29 11.2 0.2 1.3 1 0 0 1 1 1 0 Stage III sporulation protein AC/AD protein family RRM_3 PF08777.9 001318183.1_29623001_3 - 0.23 11.4 0.7 0.73 9.8 0.1 1.9 2 0 0 2 2 2 0 RNA binding motif Ig_3 PF13927.4 001302659.1_40423001_1 - 2.9e-08 34.1 0.3 0.00021 21.7 0.2 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001302659.1_40423001_1 - 3.4e-08 33.6 0.9 0.0011 19.2 0.3 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001302659.1_40423001_1 - 8.5e-07 29.0 0.0 3.3e-06 27.1 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.23 001302659.1_40423001_1 - 4.2e-06 26.7 0.4 0.06 13.4 0.1 2.7 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001302659.1_40423001_1 - 0.00067 19.5 0.0 0.072 13.0 0.0 2.6 2 1 0 2 2 2 1 Immunoglobulin I-set domain Vpu PF00558.17 001302659.1_40423001_1 - 0.096 12.3 0.5 0.23 11.1 0.5 1.5 1 0 0 1 1 1 0 Vpu protein DUF3357 PF11837.6 001302659.1_40423001_1 - 0.12 12.7 0.0 0.28 11.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) SLAM PF06214.9 001302659.1_40423001_1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Signaling lymphocytic activation molecule (SLAM) protein 60KD_IMP PF02096.18 001302659.1_40423001_1 - 0.15 11.8 0.8 0.24 11.2 0.8 1.3 1 0 0 1 1 1 0 60Kd inner membrane protein 7tm_1 PF00001.19 001302775.1_39725001_3 - 4.5e-44 150.6 28.2 4.5e-44 150.6 28.2 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001302775.1_39725001_3 - 2.4e-12 47.1 25.7 3.8e-12 46.4 25.7 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001302775.1_39725001_3 - 4.1e-10 39.3 29.7 6.8e-10 38.6 29.7 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Kunitz_BPTI PF00014.21 001246283.2_45722001_1 - 2.6e-20 72.3 2.0 7.4e-20 70.8 2.0 1.8 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain WAP PF00095.19 001246283.2_45722001_1 - 0.00017 21.8 16.7 0.00017 21.8 16.7 2.3 3 0 0 3 3 3 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' PyrBI_leader PF08052.9 001246283.2_45722001_1 - 0.066 13.0 0.6 0.066 13.0 0.6 2.0 2 0 0 2 2 2 0 PyrBI operon leader peptide ART PF01129.16 001278397.1_29623001_1 - 1.8e-86 288.9 0.0 2.2e-86 288.6 0.0 1.1 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.12 001278397.1_29623001_1 - 0.14 11.3 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme Adhes-Ig_like PF09085.8 001318179.1_29623001_1 - 4.3e-50 168.3 0.5 6.7e-50 167.7 0.5 1.3 1 0 0 1 1 1 1 Adhesion molecule, immunoglobulin-like Ig_3 PF13927.4 001318179.1_29623001_1 - 0.0039 17.6 0.0 0.0087 16.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ICAM_N PF03921.12 001318179.1_29623001_1 - 0.069 12.7 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Intercellular adhesion molecule (ICAM), N-terminal domain E1_DerP2_DerF2 PF02221.13 001305897.1_29721001_1 - 1.6e-15 57.6 0.2 1.9e-15 57.4 0.2 1.1 1 0 0 1 1 1 1 ML domain IL13 PF03487.11 001305892.1_29721001_3 - 3.9e-68 227.1 0.1 4.4e-68 226.9 0.1 1.0 1 0 0 1 1 1 1 Interleukin-13 MHC_I PF00129.16 001305902.1_29723001_1 - 1.3e-92 308.1 0.8 1.9e-92 307.6 0.8 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001305902.1_29723001_1 - 3.2e-17 62.6 0.0 7.1e-17 61.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001305902.1_29723001_1 - 2.5e-13 49.6 10.9 5.4e-13 48.5 10.9 1.6 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001305902.1_29723001_1 - 2.5e-06 27.9 0.8 0.018 15.5 0.0 3.1 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001305902.1_29723001_1 - 0.00012 21.9 1.1 0.0005 20.0 0.1 2.1 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001305902.1_29723001_1 - 0.0017 18.3 0.1 0.0061 16.6 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin domain Tetraspannin PF00335.18 001305901.1_29722001_1 - 6e-47 160.0 13.8 6.9e-47 159.8 13.8 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF21 PF01595.18 001305901.1_29722001_1 - 8.4 5.9 7.6 4 7.0 0.3 2.4 3 0 0 3 3 3 0 Domain of unknown function DUF21 MARVEL PF01284.21 001305911.1_29724001_3 - 2.7e-26 92.2 12.0 3.7e-26 91.8 12.0 1.2 1 0 0 1 1 1 1 Membrane-associating domain Occludin_ELL PF07303.11 001305911.1_29724001_3 - 6.4e-26 90.9 9.3 1.1e-25 90.1 9.3 1.4 1 0 0 1 1 1 1 Occludin homology domain Laminin_II PF06009.10 001305911.1_29724001_3 - 0.0071 16.2 0.9 0.012 15.5 0.9 1.2 1 0 0 1 1 1 1 Laminin Domain II IncA PF04156.12 001305911.1_29724001_3 - 0.012 15.3 4.6 0.012 15.3 4.6 4.3 5 0 0 5 5 4 0 IncA protein APG6 PF04111.10 001305911.1_29724001_3 - 0.033 13.5 5.5 0.049 12.9 5.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 TBPIP PF07106.11 001305911.1_29724001_3 - 0.061 13.0 4.5 0.1 12.3 4.5 1.3 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4164 PF13747.4 001305911.1_29724001_3 - 0.073 13.2 1.6 0.13 12.5 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) DUF342 PF03961.11 001305911.1_29724001_3 - 0.074 11.5 2.9 0.11 11.0 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) TMF_TATA_bd PF12325.6 001305911.1_29724001_3 - 0.12 12.5 4.7 0.22 11.6 4.7 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding UPF0184 PF03670.11 001305911.1_29724001_3 - 0.12 12.6 0.7 0.22 11.8 0.7 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) DUF4200 PF13863.4 001305911.1_29724001_3 - 0.15 12.3 10.3 0.25 11.6 10.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) AKNA PF12443.6 001305911.1_29724001_3 - 0.17 12.4 1.4 0.3 11.6 0.2 2.0 2 0 0 2 2 2 0 AT-hook-containing transcription factor KxDL PF10241.7 001305911.1_29724001_3 - 0.24 11.6 2.8 0.78 9.9 0.3 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein PRKG1_interact PF15898.3 001305911.1_29724001_3 - 0.4 11.5 8.5 1.3 9.8 8.5 1.8 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF948 PF06103.9 001305911.1_29724001_3 - 0.4 10.8 2.7 6.2 7.0 0.0 3.3 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Spc24 PF08286.9 001305911.1_29724001_3 - 0.54 10.4 3.9 1.6 8.9 1.2 2.3 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 CENP-H PF05837.10 001305911.1_29724001_3 - 0.62 10.4 2.6 1.1 9.6 2.6 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Cation_ATPase_C PF00689.19 001305911.1_29724001_3 - 0.69 9.5 10.4 2.9 7.4 10.6 1.8 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus Swi5 PF07061.9 001305911.1_29724001_3 - 0.71 9.8 5.8 0.46 10.5 3.4 1.8 1 1 1 2 2 2 0 Swi5 DUF2157 PF09925.7 001305911.1_29724001_3 - 1.6 8.4 7.1 0.48 10.1 2.7 2.3 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) EphA2_TM PF14575.4 001305911.1_29724001_3 - 2.9 8.6 0.0 2.9 8.6 0.0 4.3 3 1 0 3 3 2 0 Ephrin type-A receptor 2 transmembrane domain SUR7 PF06687.10 001305911.1_29724001_3 - 4.3 6.8 11.6 0.85 9.1 3.1 2.9 3 0 0 3 3 3 0 SUR7/PalI family MHC_II_alpha PF00993.18 001305913.1_29722001_1 - 1.8e-33 113.9 0.2 2.5e-33 113.5 0.2 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001305913.1_29722001_1 - 2.2e-29 100.5 0.3 4e-29 99.7 0.3 1.4 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001305913.1_29722001_1 - 1.7e-23 82.7 0.0 2.7e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001305913.1_29722001_1 - 3.1e-05 24.4 0.0 5.2e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001305913.1_29722001_1 - 0.0014 18.3 0.0 0.002 17.9 0.0 1.1 1 0 0 1 1 1 1 Marek's disease glycoprotein A V-set_2 PF15910.3 001305918.1_29722001_2 - 1.5e-13 50.7 1.0 2.1e-13 50.2 1.0 1.2 1 0 0 1 1 1 1 ICOS V-set domain V-set PF07686.15 001305918.1_29722001_2 - 5.3e-06 26.4 0.6 7.6e-06 25.9 0.3 1.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain Syndecan PF01034.18 001305918.1_29722001_2 - 0.13 12.1 0.1 0.24 11.2 0.1 1.4 1 0 0 1 1 1 0 Syndecan domain MHC_II_alpha PF00993.18 001305927.1_29722001_1 - 2.1e-35 120.1 0.1 3e-35 119.6 0.1 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001305927.1_29722001_1 - 1.4e-29 101.1 0.1 2.7e-29 100.2 0.1 1.5 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001305927.1_29722001_1 - 7.7e-23 80.7 0.0 1.2e-22 80.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001305927.1_29722001_1 - 3e-05 24.4 0.0 6.2e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001305927.1_29722001_1 - 0.00064 19.5 0.0 0.00098 18.9 0.0 1.3 1 0 0 1 1 1 1 Marek's disease glycoprotein A C2-set_2 PF08205.10 001305927.1_29722001_1 - 0.027 14.4 0.0 0.053 13.5 0.0 1.5 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 001305927.1_29722001_1 - 0.045 14.0 0.0 0.08 13.2 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain PA14 PF07691.10 001305927.1_29722001_1 - 0.051 13.2 0.0 0.082 12.6 0.0 1.3 1 0 0 1 1 1 0 PA14 domain MHC_II_beta PF00969.17 001305926.1_29723001_1 - 3.8e-36 122.9 1.0 6e-36 122.3 1.0 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001305926.1_29723001_1 - 8.5e-25 86.9 0.1 1.5e-24 86.1 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001305926.1_29723001_1 - 6.6e-05 23.3 0.1 0.00013 22.4 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001305926.1_29723001_1 - 0.00063 19.7 0.1 0.0012 18.8 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain DUF202 PF02656.13 001305926.1_29723001_1 - 0.071 13.4 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) MHC_II_beta PF00969.17 001305929.1_29722001_1 - 1.2e-34 118.1 0.4 2.1e-34 117.4 0.4 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001305929.1_29722001_1 - 2.6e-27 95.0 0.2 7.7e-27 93.5 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001305929.1_29722001_1 - 2.8e-06 27.7 0.0 6.2e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain MHC_I PF00129.16 001305929.1_29722001_1 - 0.00012 21.6 0.0 0.00019 20.9 0.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 ig PF00047.23 001305929.1_29722001_1 - 0.00075 19.5 0.0 0.0015 18.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 001305929.1_29722001_1 - 0.00083 19.2 0.1 0.0019 18.1 0.1 1.6 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain BST2 PF16716.3 001305931.1_29722001_1 - 3.1e-35 120.5 6.8 5.1e-35 119.8 6.8 1.3 1 0 0 1 1 1 1 Bone marrow stromal antigen 2 MAD PF05557.11 001305931.1_29722001_1 - 0.00019 19.8 4.3 0.00023 19.6 4.3 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein CALCOCO1 PF07888.9 001305931.1_29722001_1 - 0.0016 17.0 2.5 0.002 16.7 2.5 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like CENP-F_leu_zip PF10473.7 001305931.1_29722001_1 - 0.0025 17.7 3.5 0.0027 17.6 2.3 1.6 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SlyX PF04102.10 001305931.1_29722001_1 - 0.0041 17.6 3.8 0.0064 16.9 0.2 2.2 1 1 1 2 2 2 1 SlyX ATG16 PF08614.9 001305931.1_29722001_1 - 0.0042 17.2 7.4 0.0084 16.2 7.4 1.5 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) Bap31 PF05529.10 001305931.1_29722001_1 - 0.0057 16.2 2.4 0.0057 16.2 2.4 1.5 2 0 0 2 2 1 1 B-cell receptor-associated protein 31-like NRBF2 PF08961.8 001305931.1_29722001_1 - 0.009 15.5 0.5 0.012 15.1 0.5 1.2 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator Filament PF00038.19 001305931.1_29722001_1 - 0.012 15.1 4.5 0.018 14.5 4.4 1.3 1 1 0 1 1 1 0 Intermediate filament protein DUF2353 PF09789.7 001305931.1_29722001_1 - 0.013 14.9 1.0 0.016 14.5 1.0 1.2 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) CASP_C PF08172.10 001305931.1_29722001_1 - 0.017 14.3 0.7 0.022 14.0 0.7 1.3 1 0 0 1 1 1 0 CASP C terminal Lebercilin PF15619.4 001305931.1_29722001_1 - 0.02 14.4 2.9 0.03 13.8 2.9 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease TMF_DNA_bd PF12329.6 001305931.1_29722001_1 - 0.024 14.5 0.8 0.024 14.5 0.8 1.5 2 0 0 2 2 1 0 TATA element modulatory factor 1 DNA binding TMF_TATA_bd PF12325.6 001305931.1_29722001_1 - 0.03 14.4 3.7 0.07 13.2 3.5 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Tropomyosin_1 PF12718.5 001305931.1_29722001_1 - 0.031 14.3 2.4 0.031 14.3 2.4 1.7 1 1 1 2 2 2 0 Tropomyosin like Spc7 PF08317.9 001305931.1_29722001_1 - 0.038 12.7 4.4 0.047 12.4 4.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein EMP24_GP25L PF01105.22 001305931.1_29722001_1 - 0.039 13.8 0.7 0.039 13.8 0.7 1.9 2 0 0 2 2 1 0 emp24/gp25L/p24 family/GOLD IncA PF04156.12 001305931.1_29722001_1 - 0.039 13.6 14.3 0.037 13.7 12.5 2.0 1 1 0 1 1 1 0 IncA protein Tropomyosin PF00261.18 001305931.1_29722001_1 - 0.04 13.1 5.9 0.037 13.3 1.5 1.7 1 1 1 2 2 2 0 Tropomyosin GAS PF13851.4 001305931.1_29722001_1 - 0.042 13.1 3.0 0.037 13.3 1.4 1.5 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Lipoprotein_7 PF01540.14 001305931.1_29722001_1 - 0.043 13.0 0.6 0.053 12.7 0.6 1.1 1 0 0 1 1 1 0 Adhesin lipoprotein APG6 PF04111.10 001305931.1_29722001_1 - 0.048 12.9 3.0 0.062 12.6 3.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Jnk-SapK_ap_N PF09744.7 001305931.1_29722001_1 - 0.06 13.4 3.3 0.085 12.9 3.3 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 HAUS-augmin3 PF14932.4 001305931.1_29722001_1 - 0.062 12.7 2.5 0.071 12.5 2.5 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Spc24 PF08286.9 001305931.1_29722001_1 - 0.062 13.4 4.6 0.053 13.6 2.0 1.9 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 FlaC_arch PF05377.9 001305931.1_29722001_1 - 0.066 13.5 1.0 0.17 12.2 0.5 1.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) FliJ PF02050.14 001305931.1_29722001_1 - 0.067 13.3 3.6 0.16 12.0 3.6 1.5 1 1 0 1 1 1 0 Flagellar FliJ protein TPR_MLP1_2 PF07926.10 001305931.1_29722001_1 - 0.079 12.9 5.1 0.29 11.1 4.5 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein PRKG1_interact PF15898.3 001305931.1_29722001_1 - 0.086 13.6 3.4 0.13 13.1 3.4 1.2 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF972 PF06156.11 001305931.1_29722001_1 - 0.087 13.3 1.1 0.14 12.7 0.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF972) SYCE1 PF15233.4 001305931.1_29722001_1 - 0.096 12.6 2.8 0.19 11.7 2.8 1.4 1 1 0 1 1 1 0 Synaptonemal complex central element protein 1 GrpE PF01025.17 001305931.1_29722001_1 - 0.1 12.1 2.4 0.1 12.1 1.3 1.5 1 1 0 1 1 1 0 GrpE CENP-H PF05837.10 001305931.1_29722001_1 - 0.11 12.8 6.2 0.32 11.3 5.2 1.9 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF3450 PF11932.6 001305931.1_29722001_1 - 0.11 11.7 4.2 0.15 11.2 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4200 PF13863.4 001305931.1_29722001_1 - 0.11 12.7 2.7 0.17 12.1 2.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Macoilin PF09726.7 001305931.1_29722001_1 - 0.11 10.9 1.9 0.13 10.7 1.9 1.1 1 0 0 1 1 1 0 Transmembrane protein CCDC-167 PF15188.4 001305931.1_29722001_1 - 0.11 12.7 1.9 0.23 11.7 1.9 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Golgin_A5 PF09787.7 001305931.1_29722001_1 - 0.14 11.5 4.0 0.17 11.2 4.0 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 T2SSM PF04612.10 001305931.1_29722001_1 - 0.14 12.1 2.7 0.31 11.0 0.2 2.0 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein M DUF2205 PF10224.7 001305931.1_29722001_1 - 0.32 10.9 3.2 0.33 10.8 1.4 1.9 1 1 1 2 2 2 0 Predicted coiled-coil protein (DUF2205) V_ATPase_I PF01496.17 001305931.1_29722001_1 - 0.32 8.7 0.8 0.37 8.5 0.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ZapB PF06005.10 001305931.1_29722001_1 - 0.35 11.2 6.3 0.22 11.8 1.9 2.3 1 1 1 2 2 2 0 Cell division protein ZapB KELK PF15796.3 001305931.1_29722001_1 - 0.38 11.1 3.6 0.35 11.3 1.6 1.8 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase ABC_tran_CTD PF16326.3 001305931.1_29722001_1 - 0.43 10.7 4.8 6.4 7.0 4.5 2.7 1 1 0 1 1 1 0 ABC transporter C-terminal domain DivIC PF04977.13 001305931.1_29722001_1 - 2.5 7.8 7.5 1.1 8.9 0.4 2.8 1 1 2 3 3 3 0 Septum formation initiator MHC_II_alpha PF00993.18 001309005.1_29722001_1 - 8.8e-32 108.5 0.0 1.2e-31 108.1 0.0 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001309005.1_29722001_1 - 1.3e-28 98.0 0.5 2.6e-28 97.1 0.5 1.5 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001309005.1_29722001_1 - 2.6e-25 88.6 0.0 4.5e-25 87.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001309005.1_29722001_1 - 1.8e-05 25.1 0.0 3e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 001309005.1_29722001_1 - 4.8e-05 23.2 0.0 8.2e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Marek_A PF02124.13 001309005.1_29722001_1 - 8.6e-05 22.3 0.0 0.00012 21.9 0.0 1.1 1 0 0 1 1 1 1 Marek's disease glycoprotein A Ig_2 PF13895.4 001309005.1_29722001_1 - 0.029 14.6 0.0 0.052 13.8 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin domain SKG6 PF08693.8 001309005.1_29722001_1 - 0.16 11.2 1.7 0.31 10.4 1.7 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Glyco_transf_6 PF03414.11 132146.1_29724120_2 - 1.2e-100 336.3 1.5 1.6e-100 335.9 1.5 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 6 EF-hand_1 PF00036.30 001266736.1_29622001_1 - 6.5e-13 47.1 1.1 4.5e-05 22.6 0.1 3.7 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 001266736.1_29622001_1 - 2.4e-12 45.6 0.2 4.6e-06 26.0 0.1 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 001266736.1_29622001_1 - 2.3e-07 31.0 0.1 0.0086 16.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 001266736.1_29622001_1 - 9.3e-05 22.0 1.5 0.27 10.9 0.1 3.5 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 001266736.1_29622001_1 - 0.0018 17.6 0.8 0.029 13.8 0.3 2.7 3 0 0 3 3 3 1 EF hand EF-hand_9 PF14658.4 001266736.1_29622001_1 - 0.0039 17.4 0.0 0.34 11.1 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain Defensin_propep PF00879.16 001032958.2_29621001_2 - 2.5e-22 78.8 4.2 3.7e-22 78.3 4.2 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001032958.2_29621001_2 - 0.0033 17.8 8.3 0.0067 16.8 8.3 1.5 1 0 0 1 1 1 1 Mammalian defensin Inositol_P PF00459.23 001258195.1_29623001_3 - 4.2e-81 272.3 0.1 5.2e-81 272.0 0.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Ras PF00071.20 001161874.1_39522001_1 - 2.4e-58 196.2 0.1 2.8e-58 196.0 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001161874.1_39522001_1 - 6.1e-37 126.4 0.1 1.1e-36 125.6 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001161874.1_39522001_1 - 3e-14 52.7 0.0 3.8e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 001161874.1_39522001_1 - 6.5e-05 22.8 0.3 0.0091 15.8 0.1 2.3 2 1 0 2 2 2 1 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 001161874.1_39522001_1 - 0.00014 21.2 0.0 0.00018 20.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001161874.1_39522001_1 - 0.00014 21.4 0.0 0.00022 20.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001161874.1_39522001_1 - 0.00017 21.5 0.0 0.00026 20.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.7 001161874.1_39522001_1 - 0.0016 18.0 0.1 0.1 12.2 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.16 001161874.1_39522001_1 - 0.012 15.0 0.2 0.52 9.7 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B APP_N PF02177.14 001161874.1_39522001_1 - 0.063 13.5 0.4 5.4 7.3 0.0 2.7 2 1 1 3 3 3 0 Amyloid A4 N-terminal heparin-binding Perilipin PF03036.14 001113773.1_39524001_1 - 6.4e-117 390.8 0.2 8.8e-117 390.4 0.2 1.2 1 0 0 1 1 1 1 Perilipin family IZUMO PF15005.4 001164492.1_39522001_1 - 1.3e-59 200.8 3.4 2.1e-59 200.1 3.4 1.3 1 0 0 1 1 1 1 Izumo sperm-egg fusion, Ig domain-associated Izumo-Ig PF16706.3 001164492.1_39522001_1 - 1.1e-44 150.2 0.0 1.8e-44 149.5 0.0 1.3 1 0 0 1 1 1 1 Izumo-like Immunoglobulin domain Ig_2 PF13895.4 001164492.1_39522001_1 - 0.00022 21.4 0.1 0.00042 20.5 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain TMEM95 PF15203.4 001164492.1_39522001_1 - 0.003 17.1 5.6 0.015 14.8 5.6 2.1 1 1 0 1 1 1 1 TMEM95 family V-set PF07686.15 001164492.1_39522001_1 - 0.03 14.3 0.0 0.4 10.7 0.0 2.1 1 1 1 2 2 2 0 Immunoglobulin V-set domain Ig_3 PF13927.4 001164492.1_39522001_1 - 0.27 11.7 0.0 0.27 11.7 0.0 1.7 2 0 0 2 2 2 0 Immunoglobulin domain UBA_5 PF16577.3 001163043.1_39523001_1 - 5.4e-44 148.0 0.2 1.2e-43 146.9 0.2 1.6 1 0 0 1 1 1 1 UBA domain ZZ PF00569.15 001163043.1_39523001_1 - 1.9e-12 46.6 3.3 4.7e-12 45.4 3.3 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type PB1 PF00564.22 001163043.1_39523001_1 - 8.2e-12 44.7 0.0 1.5e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 PB1 domain C1_2 PF03107.14 001163043.1_39523001_1 - 0.00089 19.4 3.6 0.0021 18.2 3.6 1.6 1 0 0 1 1 1 1 C1 domain Calsarcin PF05556.9 001199222.1_39522001_1 - 4.5e-89 298.0 1.4 5.3e-89 297.7 1.4 1.0 1 0 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) CCER1 PF15482.4 001199222.1_39522001_1 - 0.06 13.1 0.2 0.14 11.9 0.0 1.7 1 1 1 2 2 2 0 Coiled-coil domain-containing glutamate-rich protein family 1 Ig_2 PF13895.4 001139448.1_39524001_1 - 1.2e-21 76.7 0.1 3.4e-12 46.4 0.0 2.5 3 0 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.4 001139448.1_39524001_1 - 1.6e-15 57.3 1.1 1.4e-07 31.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001139448.1_39524001_1 - 1.4e-09 37.9 0.0 8.5e-06 25.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001139448.1_39524001_1 - 0.0003 20.8 0.6 3.7 7.6 0.0 3.6 2 2 1 3 3 3 2 Immunoglobulin V-set domain I-set PF07679.14 001139448.1_39524001_1 - 0.16 11.9 0.0 5 7.1 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin I-set domain Lysis_col PF02402.14 001139448.1_39524001_2 - 0.34 10.7 1.2 0.87 9.4 1.2 1.6 1 0 0 1 1 1 0 Lysis protein pKID PF02173.15 001104935.1_39522001_1 - 5.4e-20 70.5 1.1 1.4e-19 69.1 1.1 1.8 1 0 0 1 1 1 1 pKID domain bZIP_1 PF00170.19 001104935.1_39522001_1 - 2.6e-19 69.0 13.0 4.6e-19 68.1 13.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001104935.1_39522001_1 - 1.6e-07 31.2 13.6 3e-07 30.3 13.6 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 001104935.1_39522001_1 - 0.014 15.8 7.4 0.029 14.8 7.4 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor TMCO5 PF14992.4 001104935.1_39522001_1 - 0.056 12.9 2.9 0.12 11.8 2.9 1.4 1 0 0 1 1 1 0 TMCO5 family KfrA_N PF11740.6 001104935.1_39522001_1 - 0.53 10.9 6.7 0.19 12.3 1.5 2.7 2 2 2 4 4 4 0 Plasmid replication region DNA-binding N-term UDPGT PF00201.16 001009189.1_39525001_1 - 6e-225 747.6 0.1 7e-225 747.4 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001009189.1_39525001_1 - 6.4e-06 26.1 0.0 1.1e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain An_peroxidase PF03098.13 001009722.1_39526001_1 - 3.8e-175 583.3 0.0 4.8e-175 583.0 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase RhoGAP PF00620.25 001267875.2_39526001_1 - 1.7e-39 135.0 0.0 2.7e-39 134.3 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain EF-hand_8 PF13833.4 001163603.1_39522001_2 - 1.4e-15 56.6 0.2 4.1e-09 35.9 0.1 3.6 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.30 001163603.1_39522001_2 - 1.9e-15 55.0 0.1 0.0015 17.8 0.0 4.6 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.4 001163603.1_39522001_2 - 9e-14 50.0 0.0 4.6e-05 22.9 0.0 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.4 001163603.1_39522001_2 - 1.2e-12 48.0 0.0 4.2e-06 27.0 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 001163603.1_39522001_2 - 1.1e-09 37.2 0.1 0.0017 17.6 0.0 3.9 4 0 0 4 4 4 2 EF hand TerB PF05099.11 001163603.1_39522001_2 - 0.028 14.3 0.0 5.1 6.9 0.0 2.1 2 0 0 2 2 2 0 Tellurite resistance protein TerB Caleosin PF05042.11 001163603.1_39522001_2 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 1 0 1 1 1 0 Caleosin related protein 7tm_1 PF00001.19 001318077.1_39523001_1 - 4.6e-49 166.9 7.3 6.1e-49 166.5 7.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001318077.1_39523001_1 - 3.2e-07 29.9 1.7 5e-07 29.2 1.7 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001318077.1_39523001_1 - 7.3e-07 29.1 1.5 1.1e-06 28.5 1.5 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001318077.1_39523001_1 - 0.041 13.1 3.1 0.068 12.3 3.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx PQ-loop PF04193.12 001126356.1_39522001_1 - 3.6e-33 113.0 0.5 2.4e-18 65.5 0.0 3.0 2 1 1 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.16 001126356.1_39522001_1 - 2.3e-05 25.1 3.7 0.11 13.1 1.2 2.3 2 0 0 2 2 2 2 ER lumen protein retaining receptor DUF737 PF05300.9 001126357.1_39522001_1 - 3.8e-45 154.6 38.2 3e-32 112.5 30.4 2.4 2 1 1 3 3 3 2 Protein of unknown function (DUF737) CHCH PF06747.11 001126357.1_39522001_1 - 0.00023 21.1 4.2 0.00044 20.2 4.2 1.5 1 0 0 1 1 1 1 CHCH domain DUF1690 PF07956.9 001126357.1_39522001_1 - 0.037 14.3 24.0 0.15 12.4 15.7 2.3 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) NDUF_B7 PF05676.11 001126357.1_39522001_1 - 0.11 12.1 4.6 0.076 12.6 2.4 1.9 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) ECH_2 PF16113.3 001126357.1_39522001_1 - 3.4 7.0 12.2 4.2 6.7 11.7 1.3 1 1 0 1 1 1 0 Enoyl-CoA hydratase/isomerase Ras PF00071.20 001126364.1_39522001_1 - 2.7e-58 196.0 0.1 3.1e-58 195.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001126364.1_39522001_1 - 2.4e-32 111.5 0.0 3.9e-32 110.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001126364.1_39522001_1 - 2.4e-13 49.8 0.1 2.8e-13 49.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001126364.1_39522001_1 - 1.7e-07 31.2 0.0 2.9e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001126364.1_39522001_1 - 2.5e-06 27.4 0.1 0.003 17.3 0.1 2.2 1 1 1 2 2 2 2 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 001126364.1_39522001_1 - 3.6e-06 26.4 0.0 4.6e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001126364.1_39522001_1 - 1.2e-05 24.8 0.1 0.00072 19.0 0.1 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Septin PF00735.16 001126364.1_39522001_1 - 0.0018 17.4 0.3 0.018 14.1 0.1 2.1 2 0 0 2 2 2 1 Septin cobW PF02492.17 001126364.1_39522001_1 - 0.0024 17.4 0.0 0.0088 15.5 0.0 1.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.15 001126364.1_39522001_1 - 0.0044 16.7 0.3 0.21 11.2 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.4 001126364.1_39522001_1 - 0.0046 17.1 0.0 0.013 15.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.7 001126364.1_39522001_1 - 0.0049 16.5 0.0 0.11 12.1 0.1 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.8 001126364.1_39522001_1 - 0.014 14.7 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.4 001126364.1_39522001_1 - 0.016 15.5 0.1 0.032 14.5 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.4 001126364.1_39522001_1 - 0.016 14.8 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.13 001126364.1_39522001_1 - 0.022 14.6 0.0 0.038 13.8 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_5 PF07728.12 001126364.1_39522001_1 - 0.022 14.6 0.0 0.038 13.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) G-alpha PF00503.18 001126364.1_39522001_1 - 0.046 12.7 1.3 0.28 10.2 0.2 2.2 2 1 1 3 3 3 0 G-protein alpha subunit ATPase_2 PF01637.16 001126364.1_39522001_1 - 0.065 13.0 0.6 0.1 12.3 0.1 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NACHT PF05729.10 001126364.1_39522001_1 - 0.081 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 NACHT domain TniB PF05621.9 001126364.1_39522001_1 - 0.095 11.7 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Abhydrolase_2 PF02230.14 001306103.1_39525001_1 - 4.8e-85 284.6 0.0 5.9e-85 284.4 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.18 001306103.1_39525001_1 - 0.0001 21.9 0.2 0.00054 19.5 0.2 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001306103.1_39525001_1 - 0.00019 22.0 0.0 0.00026 21.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.11 001306103.1_39525001_1 - 0.0003 20.6 0.0 0.0013 18.4 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 001306103.1_39525001_1 - 0.0047 16.1 0.0 0.28 10.3 0.0 2.7 2 1 1 3 3 3 1 Serine aminopeptidase, S33 Cutinase PF01083.20 001306103.1_39525001_1 - 0.0082 16.0 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Cutinase DUF2974 PF11187.6 001306103.1_39525001_1 - 0.038 13.4 0.0 0.063 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) BRICHOS PF04089.12 001099630.1_39522001_3 - 8.4e-24 83.4 0.0 1.2e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 BRICHOS domain SPESP1 PF15754.3 001318078.1_39523001_3 - 1.6e-149 497.2 6.1 1.9e-149 497.0 6.1 1.0 1 0 0 1 1 1 1 Sperm equatorial segment protein 1 Cas_Cas1 PF01867.14 001318078.1_39523001_3 - 0.085 11.9 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 CRISPR associated protein Cas1 Trypan_PARP PF05887.9 001318078.1_39523001_3 - 0.27 11.2 5.6 0.58 10.1 5.6 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Tetraspannin PF00335.18 001114764.1_39523001_1 - 4e-45 154.1 9.5 4e-45 154.1 9.5 1.4 2 0 0 2 2 2 1 Tetraspanin family DUF2371 PF10177.7 001114764.1_39523001_1 - 0.32 11.0 1.7 4.5 7.3 0.0 2.9 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2371) DUF4064 PF13273.4 001114764.1_39523001_1 - 4.1 7.7 14.0 22 5.3 6.3 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) RNase_H PF00075.22 001285962.1_39523001_1 - 4.4e-45 153.3 0.0 6.3e-45 152.7 0.0 1.2 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.14 001285962.1_39523001_1 - 3.7e-19 68.6 2.2 7.4e-19 67.7 2.2 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.4 001285962.1_39523001_1 - 0.0026 17.3 0.0 0.0083 15.7 0.0 1.9 2 1 0 2 2 2 1 Reverse transcriptase-like Arf PF00025.19 001162547.1_39522001_1 - 1.8e-76 255.3 0.1 2.1e-76 255.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 001162547.1_39522001_1 - 1.6e-14 54.0 0.1 2.2e-14 53.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 001162547.1_39522001_1 - 3e-14 52.7 0.0 3.6e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.20 001162547.1_39522001_1 - 8.5e-13 48.1 0.0 9.7e-13 47.9 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 001162547.1_39522001_1 - 1.1e-12 47.7 1.4 6e-09 35.4 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 001162547.1_39522001_1 - 2.7e-11 43.1 0.0 3.2e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001162547.1_39522001_1 - 3.6e-05 23.7 0.0 5.7e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 001162547.1_39522001_1 - 0.0073 15.5 0.2 0.015 14.5 0.1 1.4 1 1 0 1 1 1 1 6-phosphofructo-2-kinase CbiA PF01656.21 001162547.1_39522001_1 - 0.18 11.7 0.0 0.23 11.4 0.0 1.1 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Arf PF00025.19 001162555.1_39522001_1 - 1.4e-65 219.9 0.6 1.6e-65 219.7 0.6 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 001162555.1_39522001_1 - 5.3e-15 55.6 0.2 7.2e-15 55.1 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001162555.1_39522001_1 - 2.6e-13 49.8 0.2 2.8e-13 49.6 0.2 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 001162555.1_39522001_1 - 7.3e-12 44.9 0.1 9.1e-12 44.6 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 001162555.1_39522001_1 - 5.2e-09 35.6 0.4 4.6e-06 25.9 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.21 001162555.1_39522001_1 - 6.4e-07 29.3 0.1 9.2e-07 28.8 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001162555.1_39522001_1 - 1.2e-06 27.9 0.2 1.5e-06 27.7 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001162555.1_39522001_1 - 0.0097 15.3 0.2 0.07 12.5 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_14 PF13173.4 001162555.1_39522001_1 - 0.032 14.1 0.1 0.12 12.2 0.0 1.7 1 1 0 2 2 2 0 AAA domain FeoB_N PF02421.16 001162555.1_39522001_1 - 0.056 12.9 0.7 0.24 10.8 0.7 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B TniB PF05621.9 001162555.1_39522001_1 - 0.092 11.8 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein Tetraspannin PF00335.18 001127281.1_39522001_1 - 5.1e-47 160.3 13.5 5.9e-47 160.1 13.5 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF21 PF01595.18 001127281.1_39522001_1 - 1.5 8.4 6.4 1.4 8.5 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function DUF21 PMP22_Claudin PF00822.18 001163047.1_39521001_1 - 3.7e-50 169.9 15.8 4.2e-50 169.7 15.8 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001163047.1_39521001_1 - 1.2e-07 31.6 11.1 1.2e-07 31.6 11.1 2.3 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Amastin PF07344.9 001163047.1_39521001_1 - 0.002 17.9 11.5 0.0041 16.8 11.5 1.5 1 1 0 1 1 1 1 Amastin surface glycoprotein L_HMGIC_fpl PF10242.7 001163047.1_39521001_1 - 0.0067 16.5 14.1 0.012 15.7 14.1 1.6 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein DUF4064 PF13273.4 001163047.1_39521001_1 - 0.0079 16.4 12.2 0.047 13.9 10.0 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF4064) H_PPase PF03030.14 001163047.1_39521001_1 - 0.055 12.0 1.5 0.059 11.8 1.5 1.2 1 0 0 1 1 1 0 Inorganic H+ pyrophosphatase DUF973 PF06157.9 001163047.1_39521001_1 - 1 8.2 6.9 1.3 7.8 6.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF973) Fibrinogen_C PF00147.16 001308451.1_39523001_3 - 0.00044 20.0 0.5 0.00071 19.3 0.5 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain MHC_I PF00129.16 001308586.1_39523001_1 - 7.9e-87 289.3 0.0 1.1e-86 288.8 0.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001308586.1_39523001_1 - 1.8e-18 66.7 0.0 3.1e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001308586.1_39523001_1 - 1.1e-07 31.5 8.2 0.00014 21.6 2.9 2.5 2 0 0 2 2 2 2 MHC_I C-terminus Ig_3 PF13927.4 001308586.1_39523001_1 - 4.4e-05 23.9 0.5 0.00059 20.3 0.2 2.4 1 1 1 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 001308586.1_39523001_1 - 0.00028 20.8 0.6 0.00071 19.5 0.6 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001308586.1_39523001_1 - 0.001 19.1 0.2 0.0027 17.7 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001308586.1_39523001_1 - 0.0095 16.1 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain DUF4448 PF14610.4 001308586.1_39523001_1 - 0.037 13.7 0.0 0.057 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) stn_TNFRSF12A PF12191.6 001308586.1_39523001_1 - 0.083 13.0 0.2 0.19 11.9 0.0 1.6 2 0 0 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain EphA2_TM PF14575.4 001308586.1_39523001_1 - 0.1 13.3 0.1 0.24 12.1 0.1 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF2850 PF11012.6 001308586.1_39523001_1 - 0.11 12.6 0.1 0.5 10.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2850) Tyrosinase PF00264.18 001130024.1_39524001_1 - 2.6e-33 116.0 0.2 4.7e-33 115.2 0.1 1.4 2 0 0 2 2 2 1 Common central domain of tyrosinase ELFV_dehydrog_N PF02812.16 001278567.1_39525001_3 - 2.4e-61 205.2 0.0 4.6e-61 204.3 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.19 001278567.1_39525001_3 - 7e-54 183.0 0.0 5e-51 173.6 0.0 2.1 2 0 0 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 2-Hacid_dh_C PF02826.17 001278567.1_39525001_3 - 0.065 12.4 0.1 0.17 11.1 0.0 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SF3b10 PF07189.9 001278567.1_39525001_3 - 0.12 12.4 0.0 2 8.5 0.0 2.6 3 0 0 3 3 3 0 Splicing factor 3B subunit 10 (SF3b10) CAP PF00188.24 001185120.1_39523001_2 - 1.1e-23 84.3 3.8 1.6e-23 83.8 3.8 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Crisp PF08562.8 001185120.1_39523001_2 - 3.3e-20 72.3 19.7 9.5e-20 70.8 19.7 1.8 1 0 0 1 1 1 1 Crisp ShK PF01549.22 001185120.1_39523001_2 - 0.027 14.9 2.1 0.027 14.9 2.1 3.4 3 1 1 4 4 4 0 ShK domain-like 7tm_1 PF00001.19 001009265.1_39523001_1 - 2.3e-61 207.3 17.4 3.2e-61 206.8 17.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009265.1_39523001_1 - 4.1e-15 55.7 8.0 4.9e-15 55.5 8.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001009265.1_39523001_1 - 7.5e-09 35.2 4.2 8.9e-09 34.9 3.8 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.7 001009265.1_39523001_1 - 8.5e-07 28.5 4.4 1.3e-06 27.9 4.4 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.7 001009265.1_39523001_1 - 0.00031 20.0 9.6 0.007 15.6 9.6 2.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.4 001009265.1_39523001_1 - 3.5 7.1 10.7 0.16 11.5 2.6 2.2 2 1 0 2 2 2 0 Olfactory receptor LBP_BPI_CETP PF01273.23 001107792.1_45723001_1 - 1.9e-33 115.3 0.6 2.5e-33 114.9 0.6 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain FMO-like PF00743.17 001109466.1_45727001_2 - 6.2e-252 836.6 0.0 8e-252 836.2 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 001109466.1_45727001_2 - 7.6e-16 58.1 0.0 4e-11 42.6 0.0 2.4 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 001109466.1_45727001_2 - 1.3e-10 40.8 0.0 2.9e-07 29.8 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.12 001109466.1_45727001_2 - 2.8e-10 39.8 0.0 4.1e-08 32.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 001109466.1_45727001_2 - 0.0003 20.8 0.0 0.00063 19.8 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001109466.1_45727001_2 - 0.001 18.7 0.2 0.23 10.9 0.0 2.9 2 1 1 3 3 3 1 FAD dependent oxidoreductase Pyr_redox PF00070.25 001109466.1_45727001_2 - 0.0015 18.9 0.2 0.38 11.2 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.4 001109466.1_45727001_2 - 0.03 14.2 0.1 0.76 9.7 0.0 3.2 3 1 0 3 3 3 0 FAD-NAD(P)-binding Thi4 PF01946.15 001109466.1_45727001_2 - 0.03 13.5 0.1 5.9 5.9 0.0 2.4 2 0 0 2 2 2 0 Thi4 family Synapsin_C PF02750.12 001168721.1_40424001_1 - 3.5e-136 451.1 0.7 4.4e-136 450.8 0.7 1.1 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.14 001168721.1_40424001_1 - 7.7e-43 144.8 0.0 9.5e-42 141.3 0.0 2.6 2 1 1 3 3 3 1 Synapsin, N-terminal domain Synapsin_N PF10581.7 001168721.1_40424001_1 - 7.1e-21 73.7 3.1 1.7e-20 72.5 3.1 1.7 1 0 0 1 1 1 1 Synapsin N-terminal RimK PF08443.9 001168721.1_40424001_1 - 0.011 15.2 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 RimK-like ATP-grasp domain Coleoptericin PF06286.9 001168721.1_40424001_1 - 0.058 13.4 0.2 0.18 11.7 0.2 1.8 1 0 0 1 1 1 0 Coleoptericin PI31_Prot_N PF11566.6 001168729.1_40424001_1 - 7.8e-16 58.1 0.0 1.5e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal F-box-like PF12937.5 001168729.1_40424001_1 - 1.9e-09 37.1 3.7 4.5e-09 35.9 3.7 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001168729.1_40424001_1 - 0.00014 21.5 2.6 0.00035 20.2 2.6 1.7 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.9 001168729.1_40424001_1 - 0.074 13.4 0.2 0.15 12.5 0.2 1.4 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A TIMP PF00965.15 001168730.1_40422001_1 - 1e-66 224.1 7.4 1.1e-66 223.9 7.4 1.0 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase ATG_C PF09333.9 001169003.1_40429001_1 - 1.1e-28 99.3 0.0 2.8e-28 97.9 0.0 1.8 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Chorein_N PF12624.5 001169003.1_40429001_1 - 1.9e-18 66.5 0.0 3.9e-17 62.3 0.0 2.5 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 ATG2_CAD PF13329.4 001169003.1_40429001_1 - 4.5e-06 26.4 0.1 9.6e-06 25.3 0.1 1.5 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif VPS13_C PF16909.3 001169003.1_40429001_1 - 0.002 17.7 0.0 0.0042 16.7 0.0 1.4 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal Hormone_6 PF00236.16 001169005.1_40421001_1 - 0.00029 20.6 6.6 0.00045 20.0 6.6 1.4 1 1 0 1 1 1 1 Glycoprotein hormone DAN PF03045.13 001169005.1_40421001_1 - 0.00092 19.1 9.9 0.0012 18.7 9.9 1.1 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.20 001169005.1_40421001_1 - 0.00095 19.3 8.4 0.0015 18.7 8.4 1.4 1 0 0 1 1 1 1 Cystine-knot domain IL13 PF03487.11 001168759.1_40421001_1 - 2.5e-69 231.0 0.1 2.8e-69 230.8 0.1 1.0 1 0 0 1 1 1 1 Interleukin-13 Kinesin PF00225.21 001168760.1_40425001_1 - 2.4e-117 391.5 0.1 6e-117 390.2 0.1 1.7 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 001168760.1_40425001_1 - 2.3e-25 89.2 0.0 1.5e-24 86.5 0.0 2.4 2 0 0 2 2 2 1 Microtubule binding AAA_22 PF13401.4 001168760.1_40425001_1 - 0.26 11.4 8.4 1.6 8.9 0.0 3.3 3 1 0 3 3 3 0 AAA domain APG6 PF04111.10 001168760.1_40425001_1 - 0.59 9.3 43.8 0.16 11.2 17.4 2.4 2 0 0 2 2 2 0 Autophagy protein Apg6 Kinesin_assoc PF16183.3 001168760.1_40425001_1 - 0.83 9.6 16.0 3.4 7.7 15.5 2.2 1 1 0 1 1 1 0 Kinesin-associated DUF1492 PF07374.9 001168760.1_40425001_1 - 0.92 9.6 7.7 1.6 8.8 0.7 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1492) TGF_beta PF00019.18 001169009.1_40423001_1 - 3.9e-32 111.1 0.5 5.8e-32 110.6 0.5 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 001169009.1_40423001_1 - 4.9e-14 52.5 0.0 7.7e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide MMR_HSR1_Xtn PF16897.3 001168770.1_40423001_1 - 1.7e-45 153.3 0.3 2.9e-45 152.5 0.3 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.19 001168770.1_40423001_1 - 3.7e-25 87.6 0.0 8.6e-25 86.4 0.0 1.7 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.21 001168770.1_40423001_1 - 8.4e-20 70.8 0.1 2e-19 69.6 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001168770.1_40423001_1 - 8.9e-11 41.4 0.1 1.1e-09 37.8 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B ArgK PF03308.14 001168770.1_40423001_1 - 0.0033 16.3 0.4 0.022 13.6 0.1 2.0 2 0 0 2 2 2 1 ArgK protein Dynamin_N PF00350.21 001168770.1_40423001_1 - 0.0038 17.2 0.3 2.3 8.1 0.2 2.3 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.25 001168770.1_40423001_1 - 0.0059 16.0 0.1 3.9 6.8 0.0 3.7 2 2 1 3 3 3 1 Elongation factor Tu GTP binding domain Filament PF00038.19 001169017.1_40423001_1 - 7.8e-116 386.9 47.9 9.5e-116 386.6 47.9 1.1 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.12 001169017.1_40423001_1 - 5e-24 84.9 9.0 1e-23 83.9 9.0 1.5 1 0 0 1 1 1 1 Intermediate filament head (DNA binding) region Reo_sigmaC PF04582.10 001169017.1_40423001_1 - 0.00015 21.1 6.1 0.16 11.2 0.4 3.1 1 1 2 3 3 3 2 Reovirus sigma C capsid protein Spc7 PF08317.9 001169017.1_40423001_1 - 0.00041 19.2 43.1 0.0015 17.3 9.5 3.1 1 1 2 3 3 3 3 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.7 001169017.1_40423001_1 - 0.0048 17.0 40.0 0.35 11.0 8.8 4.0 1 1 3 4 4 4 2 JNK_SAPK-associated protein-1 Baculo_PEP_C PF04513.10 001169017.1_40423001_1 - 0.029 14.3 17.9 0.32 10.9 0.5 4.2 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Trimer_CC PF08954.9 001169017.1_40423001_1 - 0.03 13.7 0.2 0.03 13.7 0.2 4.1 4 0 0 4 4 3 0 Trimerisation motif DUF1664 PF07889.10 001169017.1_40423001_1 - 0.052 13.4 21.6 0.083 12.8 2.7 4.4 1 1 3 5 5 5 0 Protein of unknown function (DUF1664) Golgin_A5 PF09787.7 001169017.1_40423001_1 - 0.073 12.4 37.9 0.17 11.2 9.4 2.7 1 1 1 2 2 2 0 Golgin subfamily A member 5 GAS PF13851.4 001169017.1_40423001_1 - 0.091 12.0 41.8 0.013 14.8 11.5 4.0 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF5082 PF16888.3 001169017.1_40423001_1 - 0.15 12.2 26.7 0.74 10.0 0.2 4.9 1 1 3 5 5 5 0 Domain of unknown function (DUF5082) DUF4407 PF14362.4 001169017.1_40423001_1 - 0.18 11.0 32.4 0.54 9.4 14.1 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.10 001169017.1_40423001_1 - 0.21 11.5 42.2 0.81 9.6 10.2 3.8 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein IncA PF04156.12 001169017.1_40423001_1 - 0.27 10.9 44.7 3.1 7.4 9.4 3.9 1 1 3 4 4 4 0 IncA protein HALZ PF02183.16 001169017.1_40423001_1 - 0.27 11.3 26.0 0.86 9.7 0.1 5.9 7 1 0 7 7 5 0 Homeobox associated leucine zipper HMMR_N PF15905.3 001169017.1_40423001_1 - 0.33 10.2 37.2 0.12 11.7 5.8 3.2 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal CENP-H PF05837.10 001169017.1_40423001_1 - 0.34 11.2 34.6 0.11 12.8 3.5 4.5 1 1 2 4 4 4 0 Centromere protein H (CENP-H) Patched PF02460.16 001169017.1_40423001_1 - 0.44 8.4 4.4 0.6 8.0 4.4 1.1 1 0 0 1 1 1 0 Patched family Prefoldin PF02996.15 001169017.1_40423001_1 - 0.45 10.3 27.4 0.027 14.2 2.2 5.6 4 1 0 4 4 4 0 Prefoldin subunit KASH_CCD PF14662.4 001169017.1_40423001_1 - 0.63 9.7 41.6 0.51 10.0 0.3 4.0 1 1 2 4 4 4 0 Coiled-coil region of CCDC155 or KASH WD40_alt PF14077.4 001169017.1_40423001_1 - 0.68 9.7 10.9 34 4.3 1.5 4.9 5 0 0 5 5 4 0 Alternative WD40 repeat motif Mnd1 PF03962.13 001169017.1_40423001_1 - 0.78 9.4 35.1 8.1 6.1 17.6 3.7 1 1 2 3 3 3 0 Mnd1 family TolA_bind_tri PF16331.3 001169017.1_40423001_1 - 0.79 9.7 43.2 0.19 11.7 3.7 6.4 3 1 1 5 5 5 0 TolA binding protein trimerisation DUF573 PF04504.12 001169017.1_40423001_1 - 0.88 10.1 9.7 3.8 8.1 0.6 4.0 2 2 1 3 3 3 0 Protein of unknown function, DUF573 APG6 PF04111.10 001169017.1_40423001_1 - 0.95 8.7 41.6 0.18 11.0 9.9 3.3 1 1 2 3 3 3 0 Autophagy protein Apg6 CENP-F_leu_zip PF10473.7 001169017.1_40423001_1 - 1 9.2 36.3 0.65 9.9 4.9 3.0 2 2 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3584 PF12128.6 001169017.1_40423001_1 - 1.1 6.6 40.4 1.8 5.9 38.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) bZIP_1 PF00170.19 001169017.1_40423001_1 - 1.7 8.6 22.9 12 6.0 2.0 5.9 4 1 2 6 6 6 0 bZIP transcription factor Fib_alpha PF08702.8 001169017.1_40423001_1 - 1.9 8.5 28.4 0.25 11.4 7.0 3.9 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family SHE3 PF17078.3 001169017.1_40423001_1 - 1.9 8.0 35.4 35 3.9 8.3 3.2 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 HR1 PF02185.14 001169017.1_40423001_1 - 3 7.9 35.3 0.6 10.1 1.1 5.1 3 2 1 4 4 4 0 Hr1 repeat Lectin_N PF03954.12 001169017.1_40423001_1 - 3.2 7.4 11.2 20 4.8 0.1 3.9 1 1 0 2 2 2 0 Hepatic lectin, N-terminal domain TACC PF05010.12 001169017.1_40423001_1 - 3.3 7.3 39.0 1.6 8.4 9.9 2.5 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC) UPF0184 PF03670.11 001169017.1_40423001_1 - 3.4 8.0 9.0 0.14 12.4 0.4 2.9 2 1 0 2 2 1 0 Uncharacterised protein family (UPF0184) DUF4515 PF14988.4 001169017.1_40423001_1 - 8 6.1 42.8 0.22 11.2 9.1 3.5 1 1 3 4 4 4 0 Domain of unknown function (DUF4515) DUF4200 PF13863.4 001169017.1_40423001_1 - 9.7 6.5 43.7 56 4.0 20.2 4.7 1 1 2 3 3 2 0 Domain of unknown function (DUF4200) LIP1 PF15904.3 001169020.1_40427001_1 - 2e-44 149.7 0.6 6.2e-44 148.2 0.6 1.9 1 0 0 1 1 1 1 LKB1 serine/threonine kinase interacting protein 1 LRR_8 PF13855.4 001169020.1_40427001_1 - 2.2e-09 36.8 19.0 1.5e-05 24.5 3.0 4.3 3 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.5 001169020.1_40427001_1 - 5e-09 36.1 18.8 0.0017 18.5 0.4 5.2 3 3 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001169020.1_40427001_1 - 1.4e-05 24.7 9.4 8.1 7.2 0.4 6.8 6 1 0 6 6 6 2 Leucine Rich Repeat Zn-ribbon_8 PF09723.8 001169020.1_40427001_1 - 0.0021 18.0 1.4 0.0074 16.2 1.4 1.9 1 1 0 1 1 1 1 Zinc ribbon domain LRR_6 PF13516.4 001169020.1_40427001_1 - 0.03 14.2 5.0 11 6.3 0.0 4.5 4 0 0 4 4 4 0 Leucine Rich repeat LRR_9 PF14580.4 001169020.1_40427001_1 - 0.076 12.4 0.1 0.35 10.2 0.0 1.8 1 1 1 2 2 2 0 Leucine-rich repeat Zn_Tnp_IS1595 PF12760.5 001169020.1_40427001_1 - 0.1 12.4 0.6 5.6 6.9 0.0 2.8 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Ribosomal_L6e PF01159.17 001169020.1_40427001_1 - 0.55 10.6 3.8 0.95 9.8 3.8 1.3 1 0 0 1 1 1 0 Ribosomal protein L6e CDC45 PF02724.12 001169020.1_40427001_1 - 5 5.2 6.0 7.2 4.7 6.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Pox_Ag35 PF03286.12 001169020.1_40427001_1 - 8.5 6.0 13.5 14 5.3 13.5 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein 7tm_1 PF00001.19 001168791.1_40423001_1 - 4.3e-49 167.0 0.0 5.2e-49 166.8 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001168791.1_40423001_1 - 2.6e-06 26.9 0.0 3.7e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001168791.1_40423001_1 - 0.00021 20.6 0.0 0.0003 20.1 0.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001168791.1_40423001_1 - 0.0011 18.6 0.0 0.002 17.8 0.0 1.4 1 0 0 1 1 1 1 Olfactory receptor Git3 PF11710.6 001168791.1_40423001_1 - 0.0023 17.6 1.7 0.0041 16.8 1.7 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 PhoLip_ATPase_C PF16212.3 001168791.1_40423001_1 - 0.032 13.8 0.6 0.2 11.3 0.1 2.2 1 1 1 2 2 2 0 Phospholipid-translocating P-type ATPase C-terminal Acetyltransf_1 PF00583.23 001168793.1_40422001_1 - 1.3e-15 57.5 0.0 2e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 001168793.1_40422001_1 - 1.1e-10 41.4 0.0 1.8e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 001168793.1_40422001_1 - 1.3e-08 35.0 0.0 2.1e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 001168793.1_40422001_1 - 8.7e-08 31.9 0.0 1.7e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.5 001168793.1_40422001_1 - 0.00051 20.0 0.1 0.0013 18.7 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.3 001168793.1_40422001_1 - 0.0033 16.8 0.9 0.0034 16.8 0.0 1.4 2 0 0 2 2 2 1 Putative acetyl-transferase Acetyltransf_13 PF13880.4 001168793.1_40422001_1 - 0.0036 17.1 0.1 0.0063 16.4 0.1 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_3 PF13302.5 001168793.1_40422001_1 - 0.005 17.4 0.0 0.011 16.2 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Kelch_5 PF13854.4 001168795.1_40429001_1 - 7.9e-35 118.2 0.9 0.00014 21.6 0.0 6.7 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.4 001168795.1_40429001_1 - 3.4e-31 106.7 4.7 4.2e-06 26.7 0.0 7.6 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.23 001168795.1_40429001_1 - 2.9e-25 87.4 4.9 9.9e-06 24.9 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.4 001168795.1_40429001_1 - 5.4e-25 87.0 5.4 3e-05 23.8 0.0 6.9 4 2 2 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.4 001168795.1_40429001_1 - 2.7e-23 81.3 1.5 0.0039 17.3 0.0 6.8 5 1 1 6 6 6 5 Kelch motif Kelch_2 PF07646.13 001168795.1_40429001_1 - 8.4e-19 66.6 3.1 0.0012 18.6 0.0 6.7 6 0 0 6 6 6 4 Kelch motif fn3 PF00041.19 001168795.1_40429001_1 - 2.5e-10 40.4 0.5 0.046 13.9 0.0 5.1 5 0 0 5 5 5 3 Fibronectin type III domain zf-tcix PF14952.4 001168795.1_40429001_1 - 4.7 6.8 15.3 9.6 5.8 0.1 5.4 6 0 0 6 6 6 0 Putative treble-clef, zinc-finger, Zn-binding WAP PF00095.19 001169026.1_40422001_2 - 2.4e-16 59.7 39.3 3.8e-08 33.4 15.4 2.1 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' Syndecan PF01034.18 001169028.1_40426001_2 - 3e-24 84.6 0.3 6.8e-24 83.4 0.3 1.6 1 0 0 1 1 1 1 Syndecan domain GDI PF00996.16 001168805.1_40423001_1 - 5.1e-242 802.8 0.1 6e-242 802.6 0.1 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Amino_oxidase PF01593.22 001168805.1_40423001_1 - 0.016 14.4 0.0 0.022 13.9 0.0 1.1 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Septin PF00735.16 001169035.1_40424001_1 - 7.4e-98 327.1 1.3 7.4e-98 327.1 1.3 2.5 3 0 0 3 3 3 1 Septin MMR_HSR1 PF01926.21 001169035.1_40424001_1 - 6.2e-07 29.4 0.0 3.2e-06 27.1 0.0 2.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.4 001169035.1_40424001_1 - 0.00048 20.4 1.8 0.0025 18.1 0.0 2.7 3 0 0 3 3 3 1 AAA ATPase domain Roc PF08477.11 001169035.1_40424001_1 - 0.00076 19.6 3.4 0.0012 19.0 0.0 3.1 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.4 001169035.1_40424001_1 - 0.00087 19.4 0.0 0.00087 19.4 0.0 2.4 3 0 0 3 3 3 1 AAA domain DUF258 PF03193.14 001169035.1_40424001_1 - 0.0014 18.5 0.0 0.0014 18.5 0.0 3.6 4 0 0 4 4 4 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001169035.1_40424001_1 - 0.0034 16.8 16.3 1.5 8.1 0.5 4.8 4 1 1 5 5 5 3 Elongation factor Tu GTP binding domain Ras PF00071.20 001169035.1_40424001_1 - 0.016 14.7 0.7 0.043 13.3 0.0 2.1 2 0 0 2 2 2 0 Ras family RNA_helicase PF00910.20 001169035.1_40424001_1 - 0.025 14.8 0.0 0.073 13.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.25 001169035.1_40424001_1 - 0.061 13.7 0.0 0.061 13.7 0.0 3.5 3 1 0 3 3 3 0 ABC transporter DUF87 PF01935.15 001169035.1_40424001_1 - 1 9.2 0.0 1 9.2 0.0 3.8 3 1 0 3 3 3 0 Domain of unknown function DUF87 Exonuc_VII_L PF02601.13 001169035.1_40424001_1 - 1.7 8.0 23.3 3.2 7.1 4.4 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit cobW PF02492.17 001169035.1_40424001_1 - 2 7.9 4.6 21 4.5 0.0 3.7 5 1 0 6 6 6 0 CobW/HypB/UreG, nucleotide-binding domain APG6 PF04111.10 001169035.1_40424001_1 - 8.8 5.5 35.3 6.3 6.0 10.1 2.6 3 0 0 3 3 3 0 Autophagy protein Apg6 Ras PF00071.20 001168824.1_40422001_1 - 9.8e-40 135.7 0.0 1.2e-39 135.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001168824.1_40422001_1 - 2e-21 76.3 0.0 2.8e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SOCS_box PF07525.14 001168824.1_40422001_1 - 1.2e-07 31.8 0.4 2.5e-07 30.8 0.4 1.6 1 0 0 1 1 1 1 SOCS box Arf PF00025.19 001168824.1_40422001_1 - 2.2e-05 23.8 0.0 3.1e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Syja_N PF02383.16 001169038.1_40429001_1 - 6e-71 239.1 0.2 9e-71 238.6 0.2 1.3 1 0 0 1 1 1 1 SacI homology domain DUF1866 PF08952.9 001169038.1_40429001_1 - 2.5e-60 202.4 0.2 5.3e-60 201.4 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) Exo_endo_phos PF03372.21 001169038.1_40429001_1 - 2.1e-09 37.5 0.0 5.2e-09 36.2 0.0 1.8 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RRM_1 PF00076.20 001169038.1_40429001_1 - 0.15 11.7 0.1 0.55 10.0 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GCFC PF07842.10 001169039.1_40426001_1 - 1.1e-35 123.5 0.4 2.9e-35 122.1 0.4 1.7 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein Kunitz_BPTI PF00014.21 001168825.1_40424001_1 - 1.2e-24 86.2 8.0 2.3e-18 66.0 2.1 3.2 3 0 0 3 3 3 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Ig_3 PF13927.4 001168825.1_40424001_1 - 9.7e-16 58.0 0.0 1.9e-15 57.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001168825.1_40424001_1 - 3.8e-15 55.6 0.0 5.6e-15 55.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 001168825.1_40424001_1 - 3.5e-11 43.2 0.0 7.2e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001168825.1_40424001_1 - 6.2e-10 39.0 0.0 1e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain WAP PF00095.19 001168825.1_40424001_1 - 3.8e-09 36.7 12.4 3.8e-09 36.7 12.4 4.6 4 1 0 4 4 4 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' V-set PF07686.15 001168825.1_40424001_1 - 1.8e-06 28.0 0.1 1.2e-05 25.3 0.1 2.0 1 1 0 1 1 1 1 Immunoglobulin V-set domain Kazal_2 PF07648.13 001168825.1_40424001_1 - 7.7e-06 25.9 0.5 4.2e-05 23.5 0.5 2.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain C1-set PF07654.13 001168825.1_40424001_1 - 0.06 13.7 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin C1-set domain GARS_A PF01071.17 001169042.1_40427001_1 - 5.4e-92 306.8 0.0 1.2e-91 305.7 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Formyl_trans_N PF00551.17 001169042.1_40427001_1 - 1.8e-63 213.4 0.3 3.8e-63 212.4 0.1 1.7 2 0 0 2 2 2 1 Formyl transferase AIRS_C PF02769.20 001169042.1_40427001_1 - 2.4e-39 134.8 0.3 3.1e-38 131.2 0.0 2.9 3 0 0 3 3 3 1 AIR synthase related protein, C-terminal domain GARS_N PF02844.13 001169042.1_40427001_1 - 2.6e-35 120.9 0.8 5.1e-34 116.8 0.2 2.9 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.14 001169042.1_40427001_1 - 4.7e-28 97.2 0.5 1.2e-26 92.7 0.2 2.9 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.22 001169042.1_40427001_1 - 2.5e-16 60.0 0.4 1.2e-15 57.8 0.4 2.3 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain ATPgrasp_Ter PF15632.4 001169042.1_40427001_1 - 2e-08 33.2 0.3 8.1e-08 31.2 0.1 2.1 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.20 001169042.1_40427001_1 - 6.3e-05 22.5 0.0 0.00015 21.2 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.15 001169042.1_40427001_1 - 0.00012 21.5 2.1 0.00019 20.9 0.1 2.3 3 0 0 3 3 3 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_2 PF08442.8 001169042.1_40427001_1 - 0.00017 21.1 0.1 0.00054 19.5 0.1 1.8 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.12 001169042.1_40427001_1 - 0.001 19.0 0.0 0.0038 17.2 0.0 2.0 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.4 001169042.1_40427001_1 - 0.0011 18.5 0.1 0.0024 17.3 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.11 001169042.1_40427001_1 - 0.0036 16.7 0.2 0.0085 15.5 0.0 1.7 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus DUF498 PF04430.12 001169042.1_40427001_1 - 0.011 15.7 0.1 0.65 10.0 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF498/DUF598) RimK PF08443.9 001169042.1_40427001_1 - 0.034 13.6 0.1 0.11 11.9 0.0 1.9 2 0 0 2 2 2 0 RimK-like ATP-grasp domain Sacchrp_dh_NADP PF03435.16 001169042.1_40427001_1 - 0.069 13.3 0.1 0.31 11.2 0.1 2.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain G-patch PF01585.21 001169043.1_40429001_1 - 1.2e-15 57.1 2.4 2.4e-15 56.0 2.4 1.6 1 0 0 1 1 1 1 G-patch domain RSRP PF17069.3 001169043.1_40429001_1 - 9.8e-10 38.4 64.7 9.8e-10 38.4 64.7 5.0 3 2 1 4 4 4 1 Arginine/Serine-Rich protein 1 DND1_DSRM PF14709.5 001169043.1_40429001_1 - 6.5e-08 32.6 0.0 1.7e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 G-patch_2 PF12656.5 001169043.1_40429001_1 - 6.3e-05 22.9 1.0 6.3e-05 22.9 1.0 3.0 3 0 0 3 3 3 1 G-patch domain dsrm PF00035.24 001169043.1_40429001_1 - 0.0077 16.8 0.0 0.025 15.1 0.0 1.9 1 0 0 1 1 1 1 Double-stranded RNA binding motif Peptidase_M10 PF00413.22 001168834.1_40422001_1 - 3.9e-55 185.9 0.3 5e-55 185.5 0.3 1.1 1 0 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.4 001168834.1_40422001_1 - 1.8e-05 25.1 0.0 3.3e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 001168834.1_40422001_1 - 0.00073 19.6 0.2 0.001 19.2 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.4 001168834.1_40422001_1 - 0.0014 18.2 0.2 0.0021 17.6 0.2 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.3 001168834.1_40422001_1 - 0.0018 17.4 0.1 0.0027 16.8 0.1 1.2 1 0 0 1 1 1 1 Met-zincin Peptidase_M57 PF12388.6 001168834.1_40422001_1 - 0.0019 17.7 0.1 0.0025 17.3 0.1 1.2 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Astacin PF01400.22 001168834.1_40422001_1 - 0.011 15.2 2.6 0.41 10.1 0.1 2.6 3 0 0 3 3 3 0 Astacin (Peptidase family M12A) Peptidase_M43 PF05572.11 001168834.1_40422001_1 - 0.018 14.8 0.3 0.037 13.8 0.3 1.4 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A Metallopep PF12044.6 001168834.1_40422001_1 - 0.038 12.5 0.7 0.068 11.6 0.2 1.6 2 0 0 2 2 2 0 Putative peptidase family Peptidase_M66 PF10462.7 001168834.1_40422001_1 - 0.038 12.8 0.6 0.038 12.8 0.6 1.7 2 0 0 2 2 2 0 Peptidase M66 Peptidase_M54 PF07998.9 001168834.1_40422001_1 - 0.052 13.4 0.0 0.081 12.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M54 zf-RING_UBOX PF13445.4 001169054.1_40423001_1 - 1.2e-11 44.3 3.5 1.7e-11 43.8 1.9 2.2 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001169054.1_40423001_1 - 9.1e-11 41.6 7.2 9.1e-11 41.6 7.2 2.1 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING SPRY PF00622.26 001169054.1_40423001_1 - 3.7e-10 39.8 0.8 8.2e-10 38.7 0.2 1.9 2 0 0 2 2 2 1 SPRY domain zf-C3HC4 PF00097.23 001169054.1_40423001_1 - 7.3e-09 35.2 5.1 2.4e-08 33.5 5.1 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001169054.1_40423001_1 - 3.9e-08 33.2 4.9 3.9e-08 33.2 4.9 3.8 4 1 0 4 4 4 1 B-box zinc finger zf-C3HC4_3 PF13920.4 001169054.1_40423001_1 - 2e-06 27.4 2.6 2e-06 27.4 2.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001169054.1_40423001_1 - 6.1e-06 26.0 3.6 6.1e-06 26.0 3.6 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.4 001169054.1_40423001_1 - 6.9e-06 25.7 6.9 4.1e-05 23.2 6.9 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001169054.1_40423001_1 - 1.1e-05 25.5 5.0 1.1e-05 25.5 5.0 2.5 2 0 0 2 2 1 1 Ring finger domain zf-RING_10 PF16685.3 001169054.1_40423001_1 - 8.2e-05 22.5 2.9 8.2e-05 22.5 2.9 3.2 2 1 1 3 3 3 1 zinc RING finger of MSL2 zf-RING_6 PF14835.4 001169054.1_40423001_1 - 0.00047 19.9 3.8 0.0015 18.2 3.8 1.9 1 1 0 1 1 1 1 zf-RING of BARD1-type protein DUF2218 PF09981.7 001169054.1_40423001_1 - 0.018 15.3 1.9 0.048 13.9 1.9 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2218) zf-Di19 PF05605.10 001169054.1_40423001_1 - 0.046 13.9 4.6 10 6.4 0.0 3.5 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding ADK_lid PF05191.12 001169054.1_40423001_1 - 0.051 13.5 0.7 0.19 11.7 0.1 2.4 2 1 0 2 2 1 0 Adenylate kinase, active site lid zf-UDP PF14569.4 001169054.1_40423001_1 - 0.052 13.5 0.4 0.2 11.7 0.4 1.9 1 0 0 1 1 1 0 Zinc-binding RING-finger U-box PF04564.13 001169054.1_40423001_1 - 0.057 13.5 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 U-box domain Exonuc_VII_L PF02601.13 001169054.1_40423001_1 - 1.6 8.1 7.8 2.1 7.7 7.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Prok-RING_4 PF14447.4 001169054.1_40423001_1 - 2 8.2 15.1 1.1 9.1 9.8 3.1 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 AAA_11 PF13086.4 001169054.1_40423001_1 - 4 7.0 8.9 6.7 6.2 8.9 1.3 1 0 0 1 1 1 0 AAA domain DUF4407 PF14362.4 001169054.1_40423001_1 - 8.2 5.6 8.6 12 5.0 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Tweety PF04906.11 001169061.1_40423001_1 - 5.2e-133 443.5 0.6 6.9e-133 443.1 0.6 1.0 1 0 0 1 1 1 1 Tweety Prominin PF05478.9 001169061.1_40423001_1 - 0.55 8.0 1.6 7.4 4.2 1.5 2.4 1 1 1 2 2 2 0 Prominin DUF4131 PF13567.4 001169061.1_40423001_1 - 6 6.3 9.5 0.23 10.9 2.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Homeobox PF00046.27 001169063.1_40423001_1 - 7.6e-22 76.8 6.9 1.2e-21 76.1 6.9 1.3 1 0 0 1 1 1 1 Homeobox domain DUF4074 PF13293.4 001169064.1_40423001_1 - 9.2e-32 109.0 7.8 2.7e-31 107.5 7.8 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4074) Homeobox PF00046.27 001169064.1_40423001_1 - 2.2e-21 75.3 4.9 4.1e-21 74.4 4.9 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001169064.1_40423001_1 - 8.9 6.2 8.7 0.81 9.5 0.7 2.9 3 0 0 3 3 3 0 Homeobox KN domain Caldesmon PF02029.13 001169066.1_40422001_1 - 4.5e-26 91.6 19.0 5.4e-26 91.3 5.6 2.5 2 1 0 2 2 2 2 Caldesmon DASH_Dad1 PF08649.8 001169066.1_40422001_1 - 0.17 11.9 0.0 0.39 10.8 0.0 1.5 1 0 0 1 1 1 0 DASH complex subunit Dad1 GIDA PF01134.20 001169072.1_40425001_1 - 4.3e-146 486.9 0.0 6.8e-146 486.2 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.4 001169072.1_40425001_1 - 1.3e-58 198.0 0.0 1.9e-58 197.4 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.5 001169072.1_40425001_1 - 1.5e-06 27.8 0.1 2.1e-06 27.2 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 001169072.1_40425001_1 - 5.4e-06 25.6 1.8 6.4e-05 22.1 0.9 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.12 001169072.1_40425001_1 - 1.6e-05 24.2 0.5 3.7e-05 23.0 0.5 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.19 001169072.1_40425001_1 - 0.0008 18.6 0.0 0.0018 17.5 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.12 001169072.1_40425001_1 - 0.0025 16.4 0.3 0.012 14.2 0.2 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.25 001169072.1_40425001_1 - 0.014 15.8 0.1 0.038 14.4 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001169072.1_40425001_1 - 0.09 11.9 0.0 0.26 10.4 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase PhyH PF05721.11 001169080.1_40422001_1 - 8.9e-49 166.5 0.0 4.9e-33 115.0 0.0 2.1 1 1 1 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) Nop PF01798.16 001168873.1_40423001_1 - 2.7e-84 282.1 0.3 2.7e-84 282.1 0.3 1.9 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.7 001168873.1_40423001_1 - 1e-45 155.4 2.0 2.8e-45 154.0 2.0 1.8 1 0 0 1 1 1 1 Prp31 C terminal domain Cytokin_check_N PF10407.7 001168873.1_40423001_1 - 0.062 13.1 0.5 8.5 6.3 0.0 3.1 3 0 0 3 3 3 0 Cdc14 phosphatase binding protein N-terminus Frankia_peptide PF14407.4 001168873.1_40423001_1 - 0.77 9.7 4.0 2.6 8.0 0.1 2.6 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. MBOAT PF03062.17 001168877.1_40423001_1 - 6.8e-33 114.3 5.1 7e-33 114.3 4.5 1.3 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DUF1925 PF09094.9 001168877.1_40423001_1 - 0.057 13.6 0.5 0.11 12.7 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1925) TGFb_propeptide PF00688.16 001169087.1_40423001_1 - 1.4e-52 178.8 0.2 2e-52 178.3 0.2 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001169087.1_40423001_1 - 4.7e-34 117.3 0.5 9.4e-34 116.3 0.5 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain Tnp_DNA_bind PF14706.4 001169087.1_40423001_1 - 0.025 14.3 0.1 2.4 7.9 0.0 2.7 2 0 0 2 2 2 0 Transposase DNA-binding SF1-HH PF16275.3 001169091.1_40424001_1 - 3.7e-44 149.6 1.7 3.7e-44 149.6 1.7 2.1 2 0 0 2 2 2 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.27 001169091.1_40424001_1 - 1.6e-07 30.9 1.1 3.6e-07 29.8 1.1 1.6 1 1 0 1 1 1 1 KH domain zf-CCHC PF00098.21 001169091.1_40424001_1 - 0.0001 22.1 1.6 0.0002 21.1 1.6 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.4 001169091.1_40424001_1 - 0.019 14.5 1.3 0.11 12.2 0.8 2.5 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.4 001169091.1_40424001_1 - 0.06 13.2 0.2 0.13 12.1 0.2 1.5 1 0 0 1 1 1 0 Zinc knuckle UPF0181 PF03701.12 001169091.1_40424001_1 - 0.42 10.1 0.0 0.42 10.1 0.0 2.4 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0181) RRM_1 PF00076.20 001169095.1_40424001_1 - 3.1e-42 142.1 0.0 4e-24 84.1 0.0 3.7 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.4 001169095.1_40424001_1 - 4.3e-27 94.8 0.2 1.3e-26 93.3 0.2 1.9 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.3 001169095.1_40424001_1 - 7.3e-05 22.4 0.0 0.013 15.2 0.0 3.3 3 1 0 3 3 3 1 Occluded RNA-recognition motif RRM_5 PF13893.4 001169095.1_40424001_1 - 0.0055 16.2 0.0 0.26 10.8 0.0 2.3 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 PF10243.7 001169095.1_40424001_1 - 0.0067 15.1 22.0 0.0095 14.6 22.0 1.2 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 RRM_7 PF16367.3 001169095.1_40424001_1 - 0.027 14.5 0.0 0.15 12.1 0.0 2.3 1 0 0 1 1 1 0 RNA recognition motif DUF1866 PF08952.9 001169095.1_40424001_1 - 0.12 12.1 0.0 13 5.5 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1866) CDC45 PF02724.12 001169095.1_40424001_1 - 0.32 9.1 18.4 0.42 8.7 18.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.15 001169095.1_40424001_1 - 1 7.9 10.5 1.5 7.4 10.5 1.1 1 0 0 1 1 1 0 Presenilin DDHD PF02862.15 001169095.1_40424001_1 - 1.6 8.6 7.2 1.3 9.0 5.0 1.9 2 0 0 2 2 2 0 DDHD domain NPR3 PF03666.11 001169095.1_40424001_1 - 5.4 5.6 15.4 7.8 5.0 15.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4700 PF15771.3 001169095.1_40424001_1 - 6.7 5.2 14.9 10 4.6 14.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4700) COPIIcoated_ERV PF07970.10 001169094.1_40423001_1 - 2e-92 308.9 1.2 2.6e-92 308.5 1.2 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.4 001169094.1_40423001_1 - 2.8e-32 110.8 0.1 6e-32 109.7 0.0 1.6 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) I-set PF07679.14 001169097.1_40423001_1 - 1.3e-71 236.5 0.0 9.3e-21 73.6 0.0 4.1 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.4 001169097.1_40423001_1 - 5.8e-43 145.2 0.0 4.8e-12 46.2 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 001169097.1_40423001_1 - 3.3e-24 84.7 0.0 5.5e-06 26.3 0.0 5.1 4 1 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.4 001169097.1_40423001_1 - 9.2e-24 83.5 0.0 1.5e-06 28.4 0.0 4.2 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.15 001169097.1_40423001_1 - 6.2e-14 52.0 0.1 0.0031 17.5 0.0 5.8 4 2 1 5 5 5 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 001169097.1_40423001_1 - 4.2e-08 33.0 0.2 1.6 8.7 0.1 4.4 4 1 0 4 4 4 3 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 001169097.1_40423001_1 - 1.3e-07 31.8 0.0 0.12 12.8 0.0 4.4 4 0 0 4 4 4 2 Immunoglobulin C1-set domain SPEG_u2 PF16650.3 001169097.1_40423001_1 - 0.00034 20.6 1.3 0.00093 19.2 1.3 1.8 1 0 0 1 1 1 1 Unstructured region on SPEG complex protein Izumo-Ig PF16706.3 001169097.1_40423001_1 - 0.00066 19.5 0.3 0.086 12.8 0.1 3.1 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Ig_5 PF16681.3 001169097.1_40423001_1 - 0.0064 16.8 0.2 7.2 7.0 0.0 3.8 4 1 0 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Herpes_gE PF02480.14 001169097.1_40423001_1 - 0.0089 14.7 0.0 1.3 7.6 0.0 2.9 3 0 0 3 3 3 1 Alphaherpesvirus glycoprotein E Ig_4 PF16680.3 001169097.1_40423001_1 - 0.01 16.1 0.9 2.2 8.6 0.1 3.3 3 0 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain V-set_CD47 PF08204.9 001169097.1_40423001_1 - 0.024 14.5 0.1 5.4 6.9 0.0 3.1 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain Homeobox PF00046.27 001168896.1_40422001_1 - 3.1e-22 78.0 8.8 4.8e-22 77.4 8.8 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001168896.1_40422001_1 - 0.11 12.3 0.7 0.34 10.7 0.7 1.8 1 0 0 1 1 1 0 Homeobox KN domain DUF2209 PF09974.7 001168896.1_40422001_1 - 0.12 12.6 0.1 0.17 12.1 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Terminase_5 PF06056.10 001168896.1_40422001_1 - 0.12 12.1 0.2 0.73 9.6 0.2 2.0 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) Homeobox PF00046.27 001168897.1_40422001_1 - 6.2e-22 77.0 8.0 9.5e-22 76.5 8.0 1.3 1 0 0 1 1 1 1 Homeobox domain DUF2209 PF09974.7 001168897.1_40422001_1 - 0.071 13.3 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Terminase_5 PF06056.10 001168897.1_40422001_1 - 0.076 12.8 0.2 0.17 11.7 0.2 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Homeobox_KN PF05920.9 001168897.1_40422001_1 - 0.12 12.1 0.8 0.26 11.1 0.8 1.5 1 0 0 1 1 1 0 Homeobox KN domain DUF739 PF05339.9 001168897.1_40422001_1 - 0.19 11.8 0.2 0.35 10.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF739) DUF3528 PF12045.6 001168900.1_40422001_1 - 3.3e-64 215.7 0.2 4.8e-64 215.1 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3528) Homeobox PF00046.27 001168900.1_40422001_1 - 4.3e-20 71.1 7.4 6.7e-20 70.5 7.4 1.3 1 0 0 1 1 1 1 Homeobox domain DTHCT PF08070.9 001168900.1_40422001_1 - 0.019 15.6 1.5 0.035 14.7 1.5 1.4 1 0 0 1 1 1 0 DTHCT (NUC029) region Homeobox_KN PF05920.9 001168900.1_40422001_1 - 0.046 13.5 0.8 0.096 12.5 0.8 1.5 1 0 0 1 1 1 0 Homeobox KN domain DUF1178 PF06676.9 001168900.1_40422001_2 - 0.33 11.2 0.2 0.33 11.2 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) Hox9_act PF04617.11 001168899.1_40422001_1 - 7.6e-70 235.3 0.6 1.1e-69 234.8 0.6 1.2 1 0 0 1 1 1 1 Hox9 activation region Homeobox PF00046.27 001168899.1_40422001_1 - 8.2e-21 73.5 6.4 1.2e-20 72.9 6.4 1.3 1 0 0 1 1 1 1 Homeobox domain HTH_23 PF13384.4 001168899.1_40422001_1 - 0.015 15.0 0.0 0.032 13.9 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Homeobox PF00046.27 001168901.1_40422001_1 - 3.3e-18 65.1 7.9 4.8e-18 64.6 7.9 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001168901.1_40422001_1 - 0.0002 21.1 2.1 0.00038 20.1 2.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain HoxA13_N PF12284.6 001168901.1_40422001_1 - 0.00027 21.4 0.1 0.0006 20.3 0.1 1.6 1 0 0 1 1 1 1 Hox protein A13 N terminal CarbpepA_inh PF02977.13 001168901.1_40422001_2 - 0.045 13.4 0.8 0.1 12.3 0.8 1.6 1 0 0 1 1 1 0 Carboxypeptidase A inhibitor Ribosomal_L23 PF00276.18 001168907.1_40421001_1 - 9.2e-11 41.8 0.1 1.2e-10 41.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L23 MDFI PF15316.4 001168923.1_40422001_1 - 1.2e-73 247.1 38.8 1.2e-73 247.1 38.8 1.4 2 0 0 2 2 2 1 MyoD family inhibitor GRIP PF01465.18 001168926.1_40425001_1 - 7e-16 57.7 0.0 1.8e-15 56.5 0.0 1.8 1 0 0 1 1 1 1 GRIP domain LPP PF04728.11 001168926.1_40425001_1 - 0.011 15.9 1.0 0.011 15.9 1.0 5.8 6 2 1 7 7 7 0 Lipoprotein leucine-zipper DUF1537 PF07005.9 001168926.1_40425001_1 - 0.63 9.6 0.0 0.63 9.6 0.0 3.1 4 0 0 4 4 4 0 Putative sugar-binding N-terminal domain Golgin_A5 PF09787.7 001168926.1_40425001_1 - 0.87 8.9 102.2 0.31 10.3 16.7 5.7 3 1 1 6 6 6 0 Golgin subfamily A member 5 PAX PF00292.16 001168929.1_40422001_1 - 3.7e-55 185.1 0.1 4.6e-55 184.8 0.1 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.4 001168929.1_40422001_1 - 4.3e-05 23.9 0.1 0.0031 18.0 0.0 2.6 3 0 0 3 3 3 1 Homeodomain-like domain HTH_23 PF13384.4 001168929.1_40422001_1 - 0.00013 21.5 0.0 0.00063 19.3 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.4 001168929.1_40422001_1 - 0.028 14.4 0.0 0.091 12.8 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_38 PF13936.4 001168929.1_40422001_1 - 0.043 13.5 0.1 0.29 10.8 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain SET PF00856.26 001168931.1_40422001_1 - 0.00023 21.4 0.2 0.00033 21.0 0.2 1.5 1 1 0 1 1 1 1 SET domain RTTN_N PF14726.4 001168931.1_40422001_1 - 0.15 12.8 0.4 0.25 12.1 0.4 1.3 1 0 0 1 1 1 0 Rotatin, an armadillo repeat protein, centriole functioning Phosphodiest PF01663.20 001168933.1_40426001_1 - 4.6e-92 309.2 0.0 6.4e-92 308.8 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Somatomedin_B PF01033.15 001168933.1_40426001_1 - 3.9e-15 55.8 44.3 8e-09 35.6 13.5 3.1 3 0 0 3 3 3 2 Somatomedin B domain Endonuclease_NS PF01223.21 001168933.1_40426001_1 - 2.1e-09 37.4 0.0 3.6e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Sulfatase PF00884.21 001168933.1_40426001_1 - 0.0005 19.4 0.0 0.047 12.9 0.0 2.2 2 0 0 2 2 2 2 Sulfatase Metalloenzyme PF01676.16 001168933.1_40426001_1 - 0.014 14.7 0.0 0.024 13.9 0.0 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily Cys_knot PF00007.20 001168934.1_40423001_1 - 4e-17 62.3 10.5 4e-17 62.3 10.5 3.8 4 1 1 5 5 5 1 Cystine-knot domain VWC PF00093.16 001168934.1_40423001_1 - 6.9e-11 42.2 9.2 6.9e-11 42.2 9.2 5.0 3 2 0 3 3 3 1 von Willebrand factor type C domain IGFBP PF00219.16 001168934.1_40423001_1 - 1.8e-10 41.2 21.1 1.8e-10 41.2 21.1 5.6 3 2 3 6 6 6 1 Insulin-like growth factor binding protein TSP_1 PF00090.17 001168934.1_40423001_1 - 2.7e-05 24.2 7.8 2.7e-05 24.2 7.8 3.7 3 0 0 3 3 3 1 Thrombospondin type 1 domain zf-C2H2_11 PF16622.3 001168951.1_40428001_1 - 4.3e-18 64.6 9.9 1.2e-14 53.6 0.4 8.8 11 0 0 11 11 11 4 zinc-finger C2H2-type zf-C2H2_4 PF13894.4 001168951.1_40428001_1 - 6.3e-18 63.8 98.9 0.016 15.8 2.2 14.4 14 0 0 14 14 14 12 C2H2-type zinc finger zf-C2H2 PF00096.24 001168951.1_40428001_1 - 1.1e-14 53.8 100.4 0.0084 16.4 1.9 14.4 14 0 0 14 14 14 11 Zinc finger, C2H2 type zf-met PF12874.5 001168951.1_40428001_1 - 0.00011 22.3 48.9 0.01 16.1 1.3 10.2 11 0 0 11 11 11 4 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 001168951.1_40428001_1 - 0.029 14.7 0.5 0.029 14.7 0.5 12.8 16 0 0 16 16 16 0 Zinc-finger double domain zf-C2H2_jaz PF12171.6 001168951.1_40428001_1 - 0.032 14.4 29.4 0.19 11.9 0.1 9.1 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_4 PF13717.4 001168951.1_40428001_1 - 7.1 6.5 19.1 30 4.5 0.1 7.1 6 1 0 6 6 6 0 zinc-ribbon domain SBP56 PF05694.9 001168953.1_40423001_1 - 4.5e-193 642.0 0.0 5.1e-193 641.9 0.0 1.0 1 0 0 1 1 1 1 56kDa selenium binding protein (SBP56) Lactonase PF10282.7 001168953.1_40423001_1 - 0.00031 20.0 0.0 0.0013 17.9 0.0 1.8 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller DUF4200 PF13863.4 001168956.1_40423001_1 - 1.8e-06 28.2 39.5 0.00051 20.3 14.3 3.2 2 1 1 3 3 3 2 Domain of unknown function (DUF4200) 2_5_RNA_ligase2 PF13563.4 001168956.1_40423001_1 - 0.00068 19.4 0.6 0.0017 18.2 0.6 1.7 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily DUF2046 PF09755.7 001168956.1_40423001_1 - 0.0021 17.2 29.1 0.11 11.6 12.5 3.2 1 1 2 3 3 3 2 Uncharacterized conserved protein H4 (DUF2046) Reo_sigmaC PF04582.10 001168956.1_40423001_1 - 0.0026 17.1 1.1 0.0026 17.1 1.1 2.2 1 1 1 2 2 2 1 Reovirus sigma C capsid protein HOOK PF05622.10 001168956.1_40423001_1 - 0.0072 14.4 34.8 0.096 10.7 24.8 2.2 1 1 1 2 2 2 2 HOOK protein BLOC1_2 PF10046.7 001168956.1_40423001_1 - 0.018 15.2 1.3 0.018 15.2 1.3 4.7 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Jnk-SapK_ap_N PF09744.7 001168956.1_40423001_1 - 0.019 15.1 16.7 0.019 15.1 16.7 3.2 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 TACC PF05010.12 001168956.1_40423001_1 - 0.032 13.9 33.5 1 9.0 6.4 4.1 2 1 2 4 4 4 0 Transforming acidic coiled-coil-containing protein (TACC) Fez1 PF06818.13 001168956.1_40423001_1 - 0.036 14.4 32.0 0.98 9.7 6.2 3.1 1 1 2 3 3 3 0 Fez1 DUF4713 PF15831.3 001168956.1_40423001_1 - 0.044 14.1 0.1 0.1 12.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) TSC22 PF01166.16 001168956.1_40423001_1 - 0.072 13.3 0.6 0.072 13.3 0.6 4.9 5 0 0 5 5 4 0 TSC-22/dip/bun family PKcGMP_CC PF16808.3 001168956.1_40423001_1 - 0.088 12.6 20.7 0.4 10.5 2.4 5.1 4 1 2 6 6 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ADIP PF11559.6 001168956.1_40423001_1 - 0.13 12.2 34.4 0.54 10.2 12.2 3.6 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding CALCOCO1 PF07888.9 001168956.1_40423001_1 - 0.16 10.4 33.0 0.011 14.2 26.7 1.9 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Filament PF00038.19 001168956.1_40423001_1 - 0.16 11.4 38.7 0.37 10.2 7.7 3.5 1 1 3 4 4 4 0 Intermediate filament protein Bacillus_HBL PF05791.9 001168956.1_40423001_1 - 0.33 10.5 13.2 0.61 9.7 1.4 3.2 3 0 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) bZIP_1 PF00170.19 001168956.1_40423001_1 - 0.42 10.6 26.3 0.16 11.9 1.0 5.3 3 1 1 5 5 5 0 bZIP transcription factor Chrome_Resist PF09828.7 001168956.1_40423001_1 - 0.43 10.9 2.7 5 7.4 0.3 2.5 1 1 1 2 2 2 0 Chromate resistance exported protein NPV_P10 PF05531.10 001168956.1_40423001_1 - 0.53 10.6 18.3 1.7 9.0 0.1 5.0 2 2 2 5 5 5 0 Nucleopolyhedrovirus P10 protein Tropomyosin_1 PF12718.5 001168956.1_40423001_1 - 0.68 9.9 41.3 0.32 11.0 15.3 3.0 2 1 1 3 3 3 0 Tropomyosin like DUF1664 PF07889.10 001168956.1_40423001_1 - 0.79 9.6 21.1 0.19 11.6 5.1 4.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) AAA_15 PF13175.4 001168956.1_40423001_1 - 1.1 8.7 13.7 0.019 14.5 3.3 2.0 1 1 0 2 2 2 0 AAA ATPase domain TMF_TATA_bd PF12325.6 001168956.1_40423001_1 - 1.1 9.3 38.6 0.27 11.3 11.2 4.3 2 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding DUF3734 PF12536.6 001168956.1_40423001_1 - 1.6 9.0 11.0 0.95 9.7 0.3 3.6 3 1 0 3 3 3 0 Patatin phospholipase Tropomyosin PF00261.18 001168956.1_40423001_1 - 1.7 7.8 41.5 0.34 10.1 16.0 4.0 2 1 2 4 4 4 0 Tropomyosin Spc7 PF08317.9 001168956.1_40423001_1 - 1.8 7.2 39.2 2.1 7.0 13.5 3.0 1 1 1 2 2 2 0 Spc7 kinetochore protein ATG16 PF08614.9 001168956.1_40423001_1 - 2.1 8.3 39.8 1.2 9.2 10.0 3.1 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Tektin PF03148.12 001168956.1_40423001_1 - 2.3 6.8 32.4 2.8 6.5 1.2 4.1 2 1 1 3 3 3 0 Tektin family USP8_interact PF08941.8 001168956.1_40423001_1 - 2.9 7.5 14.5 0.1 12.3 0.7 3.2 3 0 0 3 3 3 0 USP8 interacting Atg14 PF10186.7 001168956.1_40423001_1 - 2.9 6.7 36.6 2.4 7.0 7.9 3.1 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF948 PF06103.9 001168956.1_40423001_1 - 3.1 8.0 14.6 1.2 9.3 1.2 4.0 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) APG6 PF04111.10 001168956.1_40423001_1 - 3.1 7.0 35.3 3.5 6.8 15.9 2.6 1 1 1 2 2 2 0 Autophagy protein Apg6 IncA PF04156.12 001168956.1_40423001_1 - 4.6 6.9 45.1 16 5.0 7.1 3.3 1 1 1 2 2 2 0 IncA protein Fib_alpha PF08702.8 001168956.1_40423001_1 - 5.1 7.1 26.0 3.4 7.7 5.1 3.4 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family MAD PF05557.11 001168956.1_40423001_1 - 5.3 5.1 38.1 0.56 8.3 22.6 2.3 1 1 1 2 2 2 0 Mitotic checkpoint protein DUF4201 PF13870.4 001168956.1_40423001_1 - 5.3 6.5 33.1 1.3 8.5 14.9 3.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) GAS PF13851.4 001168956.1_40423001_1 - 5.4 6.2 37.2 5 6.3 14.2 2.8 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Vps5 PF09325.8 001168956.1_40423001_1 - 6.2 6.2 23.3 0.41 10.0 5.1 3.8 2 1 2 4 4 4 0 Vps5 C terminal like HIP1_clath_bdg PF16515.3 001168956.1_40423001_1 - 7 7.2 35.5 0.7 10.4 11.3 3.5 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4988 PF16378.3 001168956.1_40423001_1 - 7.2 6.0 11.2 1.7 8.1 0.7 3.7 3 1 1 4 4 4 0 Domain of unknown function Occludin_ELL PF07303.11 001168956.1_40423001_1 - 8.9 7.0 20.9 3.2 8.4 5.1 3.8 2 1 2 4 4 4 0 Occludin homology domain Aminopep PF10023.7 001168956.1_40423001_1 - 10 5.3 16.1 0.094 11.9 4.7 2.3 1 1 1 2 2 2 0 Putative aminopeptidase TP53IP5 PF15331.4 001168735.1_40422001_1 - 8.9e-109 362.6 11.7 1.4e-108 362.0 11.7 1.3 1 0 0 1 1 1 1 Cellular tumour antigen p53-inducible 5 PX PF00787.22 001168957.1_40424001_1 - 2.2e-19 69.4 0.1 4.7e-19 68.3 0.1 1.5 1 0 0 1 1 1 1 PX domain PDZ PF00595.22 001168957.1_40424001_1 - 3.1e-14 52.9 0.3 6.1e-14 52.0 0.3 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) RA PF00788.21 001168957.1_40424001_1 - 1.6e-11 44.6 0.0 4.4e-11 43.1 0.0 1.8 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PDZ_2 PF13180.4 001168957.1_40424001_1 - 4.4e-05 23.6 0.5 0.0011 19.1 0.0 2.5 2 0 0 2 2 2 1 PDZ domain USP7_C2 PF14533.4 001168957.1_40424001_1 - 0.00061 19.4 0.1 0.0011 18.7 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal SSrecog PF03531.12 001168957.1_40424001_1 - 0.0012 18.0 0.0 0.0028 16.9 0.0 1.5 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) UBX PF00789.18 001168957.1_40424001_1 - 0.0091 16.0 0.0 0.023 14.7 0.0 1.7 1 0 0 1 1 1 1 UBX domain FERM_N PF09379.8 001168957.1_40424001_1 - 0.012 15.4 0.0 0.03 14.1 0.0 1.8 1 0 0 1 1 1 0 FERM N-terminal domain RBD PF02196.13 001168957.1_40424001_1 - 0.015 15.3 0.0 0.088 12.8 0.0 2.2 2 0 0 2 2 2 0 Raf-like Ras-binding domain SCAN PF02023.15 001168961.1_40426001_1 - 5.8e-43 144.5 3.0 2.1e-42 142.7 3.0 2.1 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 001168961.1_40426001_1 - 3.5e-41 137.7 45.3 1.7e-08 34.4 0.2 7.6 7 0 0 7 7 6 6 Zinc-finger double domain Myb_DNA-bind_4 PF13837.4 001168961.1_40426001_1 - 7.8e-41 138.3 0.1 1.8e-19 69.8 0.0 2.7 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain zf-C2H2 PF00096.24 001168961.1_40426001_1 - 9.2e-38 126.5 48.2 2e-06 27.8 0.5 7.0 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001168961.1_40426001_1 - 4.4e-18 64.3 49.6 0.0061 17.2 1.8 8.0 8 0 0 8 8 6 6 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001168961.1_40426001_1 - 1.1e-07 31.4 26.8 0.0033 17.0 1.2 6.5 6 0 0 6 6 6 2 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 001168961.1_40426001_1 - 2.9e-07 30.1 34.4 0.019 14.8 2.2 6.7 6 0 0 6 6 6 3 C2H2-type zinc finger MADF_DNA_bdg PF10545.7 001168961.1_40426001_1 - 2.1e-06 27.8 0.4 0.031 14.5 0.1 2.8 2 0 0 2 2 2 2 Alcohol dehydrogenase transcription factor Myb/SANT-like zf-C2H2_jaz PF12171.6 001168961.1_40426001_1 - 4.1e-06 26.8 23.4 0.23 11.7 0.5 6.5 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.9 001168961.1_40426001_1 - 0.00029 20.5 31.4 0.24 11.2 0.4 7.1 7 0 0 7 7 7 3 LYAR-type C2HC zinc finger zinc_ribbon_15 PF17032.3 001168961.1_40426001_1 - 0.0011 19.6 20.3 0.027 15.1 1.8 4.1 3 1 1 4 4 3 3 zinc-ribbon family Myb_DNA-bind_3 PF12776.5 001168961.1_40426001_1 - 0.0018 18.9 1.5 2 9.2 0.1 2.5 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 001168961.1_40426001_1 - 0.0049 17.0 0.1 2.3 8.4 0.0 3.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.29 001168961.1_40426001_1 - 0.0051 16.8 0.3 1.6 8.8 0.1 2.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Zn-ribbon_8 PF09723.8 001168961.1_40426001_1 - 0.008 16.1 40.7 0.015 15.3 1.1 6.7 5 1 5 10 10 8 4 Zinc ribbon domain DNA_RNApol_7kD PF03604.11 001168961.1_40426001_1 - 0.03 13.8 18.8 4 7.0 0.1 6.2 6 0 0 6 6 6 0 DNA directed RNA polymerase, 7 kDa subunit XPA_N PF01286.16 001168961.1_40426001_1 - 0.033 14.1 30.2 1.9 8.4 0.4 6.4 6 0 0 6 6 6 0 XPA protein N-terminal HSF_DNA-bind PF00447.15 001168961.1_40426001_1 - 0.035 14.6 0.1 10 6.6 0.0 2.6 2 0 0 2 2 2 0 HSF-type DNA-binding PPP4R2 PF09184.9 001168961.1_40426001_1 - 0.037 13.5 0.3 0.037 13.5 0.3 1.8 2 0 0 2 2 2 0 PPP4R2 OSTMP1 PF09777.7 001168961.1_40426001_1 - 0.06 12.6 12.2 5.5 6.2 4.1 3.5 3 0 0 3 3 3 0 Osteopetrosis-associated transmembrane protein 1 precursor DUF3268 PF11672.6 001168961.1_40426001_1 - 0.13 12.5 12.1 1.5 9.0 0.6 3.6 3 0 0 3 3 3 0 zinc-finger-containing domain zf-trcl PF13451.4 001168961.1_40426001_1 - 0.14 11.9 20.5 17 5.3 0.1 6.7 6 0 0 6 6 6 0 Probable zinc-ribbon domain HypA PF01155.17 001168961.1_40426001_1 - 0.17 11.8 16.3 3.5 7.5 1.0 3.9 2 1 1 4 4 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DltD_M PF04918.10 001168961.1_40426001_1 - 0.18 12.2 0.1 5 7.4 0.0 2.4 2 0 0 2 2 2 0 DltD central region DZR PF12773.5 001168961.1_40426001_1 - 0.21 11.5 29.0 0.058 13.3 2.2 4.3 3 1 2 5 5 3 0 Double zinc ribbon ADK_lid PF05191.12 001168961.1_40426001_1 - 4.5 7.2 16.0 1.2 9.1 1.0 4.4 2 2 3 5 5 5 0 Adenylate kinase, active site lid YhfH PF14149.4 001168961.1_40426001_1 - 7.4 6.5 23.6 25 4.8 0.2 6.6 7 0 0 7 7 6 0 YhfH-like protein CpXC PF14353.4 001168961.1_40426001_1 - 8.8 6.3 14.5 23 4.9 0.0 5.4 3 2 0 4 4 4 0 CpXC protein Serinc PF03348.13 001168969.1_40422001_1 - 3.5e-51 174.4 0.2 4.3e-51 174.1 0.2 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) ABC_membrane_2 PF06472.13 001168969.1_40422001_1 - 0.12 11.6 0.4 0.19 10.9 0.4 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 Serinc PF03348.13 001168969.1_40422001_3 - 3.1e-10 39.5 0.5 4e-10 39.1 0.5 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) Utp11 PF03998.11 001168970.1_40421001_1 - 0.021 14.6 3.1 0.023 14.5 3.1 1.1 1 0 0 1 1 1 0 Utp11 protein DUF4758 PF15950.3 001168970.1_40421001_1 - 0.071 13.3 0.2 0.1 12.8 0.2 1.2 1 0 0 1 1 1 0 Putative sperm flagellar membrane protein SPT6_acidic PF14632.4 001168970.1_40421001_1 - 1.1 9.8 10.0 0.26 11.8 6.2 1.7 1 1 1 2 2 2 0 Acidic N-terminal SPT6 OSTMP1 PF09777.7 001168985.1_40423001_1 - 4.4e-85 284.7 14.6 5.1e-85 284.5 14.6 1.0 1 0 0 1 1 1 1 Osteopetrosis-associated transmembrane protein 1 precursor CECR6_TMEM121 PF14997.4 001168985.1_40423001_1 - 0.009 15.7 0.5 0.016 15.0 0.3 1.6 1 1 0 1 1 1 1 CECR6/TMEM121 family Motilin_ghrelin PF04644.10 001168985.1_40423001_1 - 0.16 11.7 1.2 6.8 6.5 0.1 2.5 2 0 0 2 2 2 0 Motilin/ghrelin Crust_neurohorm PF01147.15 001168985.1_40423001_1 - 0.36 10.5 3.9 1.4 8.6 0.1 2.9 2 1 1 3 3 3 0 Crustacean CHH/MIH/GIH neurohormone family FOXP-CC PF16159.3 001168744.1_40425001_1 - 1.3e-34 118.5 4.7 1.3e-34 118.5 4.7 2.8 3 0 0 3 3 3 1 FOXP coiled-coil domain Forkhead PF00250.16 001168744.1_40425001_1 - 2.6e-28 98.1 0.2 6.6e-28 96.7 0.2 1.7 1 0 0 1 1 1 1 Forkhead domain Bestrophin PF01062.19 001168744.1_40425001_1 - 0.27 10.4 0.0 0.27 10.4 0.0 2.0 2 0 0 2 2 2 0 Bestrophin, RFP-TM, chloride channel MDFI PF15316.4 001168745.1_40422001_1 - 1.1e-55 188.6 42.1 1.3e-55 188.3 42.1 1.1 1 0 0 1 1 1 1 MyoD family inhibitor IRS PF02174.15 001168748.1_40423001_1 - 1.6e-26 91.9 0.1 2.9e-26 91.1 0.1 1.3 1 0 0 1 1 1 1 PTB domain (IRS-1 type) UCH PF00443.27 001168750.1_40425001_1 - 2.8e-57 194.0 0.3 4e-57 193.5 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.17 001168750.1_40425001_1 - 1.8e-20 72.9 6.8 1.8e-20 72.9 6.8 3.0 3 1 1 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.4 001168750.1_40425001_1 - 5.9e-17 62.1 1.4 5.3e-12 45.9 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.4 001168750.1_40425001_1 - 0.019 14.3 5.9 0.95 8.7 0.0 3.6 3 1 1 4 4 4 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase DUF4623 PF15416.4 001168750.1_40425001_3 - 0.16 10.3 0.0 0.23 9.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4623) CNH PF00780.20 001168999.1_40425001_1 - 8.6e-62 209.1 0.0 1.2e-61 208.6 0.0 1.2 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.23 001168999.1_40425001_1 - 2.7e-61 207.1 0.0 4.1e-61 206.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001168999.1_40425001_1 - 2.6e-39 135.0 0.0 3.8e-39 134.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001168999.1_40425001_1 - 0.048 12.8 0.0 0.1 11.7 0.0 1.5 1 0 0 1 1 1 0 Kinase-like zf-C2H2_7 PF15269.4 001168722.1_40424001_1 - 3.2e-36 123.1 10.0 6.9e-36 122.0 10.0 1.6 1 0 0 1 1 1 1 Zinc-finger zf-H2C2_5 PF13909.4 001168722.1_40424001_1 - 0.4 10.3 6.2 0.68 9.6 6.2 1.4 1 0 0 1 1 1 0 C2H2-type zinc-finger domain Oest_recep PF02159.13 001164587.1_40424001_1 - 5.8e-65 217.8 6.0 6.7e-65 217.6 4.3 1.9 2 0 0 2 2 2 1 Oestrogen receptor Hormone_recep PF00104.28 001164587.1_40424001_1 - 7.5e-35 120.3 3.3 1.2e-34 119.6 3.3 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001164587.1_40424001_1 - 1.5e-31 108.5 13.9 2.4e-31 107.9 13.9 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) ESR1_C PF12743.5 001164587.1_40424001_1 - 3.3e-25 87.4 1.3 6.2e-25 86.6 1.3 1.5 1 0 0 1 1 1 1 Oestrogen-type nuclear receptor final C-terminal Jiv90 PF14901.4 001164587.1_40424001_1 - 0.29 11.2 4.9 1.2 9.2 4.5 2.2 2 0 0 2 2 2 0 Cleavage inducing molecular chaperone C2-set_2 PF08205.10 001171117.1_37923001_1 - 2.9e-23 81.6 3.2 3.3e-23 81.4 0.4 2.5 3 1 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 001171117.1_37923001_1 - 2.2e-15 56.9 0.9 2.9e-05 24.4 0.5 3.6 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001171117.1_37923001_1 - 1.7e-14 53.7 0.0 6.7e-13 48.6 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.23 001171117.1_37923001_1 - 3.7e-11 42.9 0.0 0.015 15.4 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001171117.1_37923001_1 - 3.8e-07 30.2 0.8 0.04 14.1 0.0 4.1 4 1 0 4 4 4 3 Immunoglobulin domain I-set PF07679.14 001171117.1_37923001_1 - 2.6e-05 24.1 0.0 1.6 8.8 0.0 3.8 3 1 0 3 3 3 2 Immunoglobulin I-set domain C1-set PF07654.13 001171117.1_37923001_1 - 0.0022 18.3 0.0 0.021 15.2 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin C1-set domain CD34_antigen PF06365.10 001171117.1_37923001_1 - 0.2 11.1 0.0 0.37 10.2 0.0 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family RRM_1 PF00076.20 001171335.1_37924001_1 - 3.1e-42 142.1 0.0 4e-24 84.1 0.0 3.7 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.4 001171335.1_37924001_1 - 4.3e-27 94.8 0.2 1.3e-26 93.3 0.2 1.9 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.3 001171335.1_37924001_1 - 7.3e-05 22.4 0.0 0.013 15.2 0.0 3.3 3 1 0 3 3 3 1 Occluded RNA-recognition motif RRM_5 PF13893.4 001171335.1_37924001_1 - 0.0055 16.2 0.0 0.26 10.8 0.0 2.3 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 PF10243.7 001171335.1_37924001_1 - 0.0067 15.1 22.0 0.0095 14.6 22.0 1.2 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 RRM_7 PF16367.3 001171335.1_37924001_1 - 0.027 14.5 0.0 0.15 12.1 0.0 2.3 1 0 0 1 1 1 0 RNA recognition motif DUF1866 PF08952.9 001171335.1_37924001_1 - 0.12 12.1 0.0 13 5.5 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1866) CDC45 PF02724.12 001171335.1_37924001_1 - 0.32 9.1 18.4 0.42 8.7 18.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.15 001171335.1_37924001_1 - 1 7.9 10.5 1.5 7.4 10.5 1.1 1 0 0 1 1 1 0 Presenilin DDHD PF02862.15 001171335.1_37924001_1 - 1.6 8.6 7.2 1.3 9.0 5.0 1.9 2 0 0 2 2 2 0 DDHD domain NPR3 PF03666.11 001171335.1_37924001_1 - 5.4 5.6 15.4 7.8 5.0 15.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4700 PF15771.3 001171335.1_37924001_1 - 6.7 5.2 14.9 10 4.6 14.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4700) MITF_TFEB_C_3_N PF15951.3 001171339.1_37923001_1 - 5.4e-67 225.1 11.7 1.2e-66 223.9 11.7 1.6 1 0 0 1 1 1 1 MITF/TFEB/TFEC/TFE3 N-terminus DUF3371 PF11851.6 001171339.1_37923001_1 - 2.7e-36 125.3 3.6 2.7e-36 125.3 3.6 3.3 2 1 1 3 3 3 1 Domain of unknown function (DUF3371) HLH PF00010.24 001171339.1_37923001_1 - 1.5e-15 56.7 0.7 3.3e-15 55.7 0.7 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain ASF1_hist_chap PF04729.11 001171342.1_37922001_1 - 2e-72 242.1 0.1 2.4e-72 241.8 0.1 1.1 1 0 0 1 1 1 1 ASF1 like histone chaperone UPF0154 PF03672.11 001171342.1_37922001_1 - 0.07 13.0 0.0 0.15 12.0 0.0 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0154) Sugar_tr PF00083.22 001171346.1_37924001_1 - 1.4e-28 99.9 20.9 1.8e-28 99.5 20.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001171346.1_37924001_1 - 4.7e-24 84.8 61.6 2.4e-21 76.0 36.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PDZ PF00595.22 001171345.1_37922001_1 - 2e-16 60.0 0.0 3.4e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) LIM PF00412.20 001171345.1_37922001_1 - 1.3e-14 54.0 6.5 2.3e-14 53.2 6.5 1.4 1 0 0 1 1 1 1 LIM domain DUF4749 PF15936.3 001171345.1_37922001_1 - 3.4e-11 44.0 0.0 5.8e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ_2 PF13180.4 001171345.1_37922001_1 - 0.064 13.4 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 PDZ domain IRF PF00605.15 001171347.1_37922001_1 - 3.8e-41 139.5 0.6 5.8e-41 138.9 0.6 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor TGF_beta PF00019.18 001171350.1_37923001_1 - 7.4e-26 91.0 0.1 1.8e-25 89.7 0.1 1.7 1 0 0 1 1 1 1 Transforming growth factor beta like domain MMR_HSR1_Xtn PF16897.3 001171352.1_37923001_1 - 1.7e-45 153.3 0.3 2.9e-45 152.5 0.3 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.19 001171352.1_37923001_1 - 3.7e-25 87.6 0.0 8.6e-25 86.4 0.0 1.7 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.21 001171352.1_37923001_1 - 8.4e-20 70.8 0.1 2e-19 69.6 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001171352.1_37923001_1 - 8.9e-11 41.4 0.1 1.1e-09 37.8 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B ArgK PF03308.14 001171352.1_37923001_1 - 0.0033 16.3 0.4 0.022 13.6 0.1 2.0 2 0 0 2 2 2 1 ArgK protein Dynamin_N PF00350.21 001171352.1_37923001_1 - 0.0038 17.2 0.3 2.3 8.1 0.2 2.3 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.25 001171352.1_37923001_1 - 0.0059 16.0 0.1 3.9 6.8 0.0 3.7 2 2 1 3 3 3 1 Elongation factor Tu GTP binding domain LBP_BPI_CETP_C PF02886.15 001171359.1_37924001_1 - 1.6e-39 135.7 0.5 2.1e-39 135.3 0.5 1.1 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.23 001171359.1_37924001_1 - 5.3e-39 133.3 0.0 1.2e-38 132.1 0.0 1.6 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain Tweety PF04906.11 001171395.1_37923001_1 - 3.3e-160 533.1 0.1 3.8e-160 532.9 0.1 1.0 1 0 0 1 1 1 1 Tweety SUR7 PF06687.10 001171395.1_37923001_1 - 0.24 10.9 3.1 7 6.1 2.2 2.4 2 0 0 2 2 2 0 SUR7/PalI family Amastin PF07344.9 001171395.1_37923001_1 - 0.41 10.4 4.6 0.49 10.1 1.4 2.2 2 0 0 2 2 2 0 Amastin surface glycoprotein Prominin PF05478.9 001171395.1_37923001_1 - 1.9 6.2 4.5 9.9 3.8 0.0 2.6 3 0 0 3 3 3 0 Prominin DUF4131 PF13567.4 001171395.1_37923001_1 - 6.4 6.2 14.8 0.25 10.8 2.3 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Hox9_act PF04617.11 001171403.1_37922001_1 - 1.2e-65 221.7 0.8 1.8e-65 221.1 0.8 1.3 1 0 0 1 1 1 1 Hox9 activation region Homeobox PF00046.27 001171403.1_37922001_1 - 8.5e-21 73.4 6.4 1.3e-20 72.9 6.4 1.3 1 0 0 1 1 1 1 Homeobox domain HTH_23 PF13384.4 001171403.1_37922001_1 - 0.014 15.1 0.1 0.033 13.9 0.0 1.6 2 0 0 2 2 2 0 Homeodomain-like domain DUF3528 PF12045.6 001171404.1_37922001_1 - 4.9e-64 215.1 0.3 7e-64 214.6 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3528) Homeobox PF00046.27 001171404.1_37922001_1 - 4.4e-20 71.1 7.4 6.8e-20 70.5 7.4 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001171404.1_37922001_1 - 0.047 13.5 0.8 0.096 12.5 0.8 1.5 1 0 0 1 1 1 0 Homeobox KN domain Homeobox PF00046.27 001171405.1_37923001_1 - 5.2e-21 74.1 4.6 7.7e-21 73.5 4.6 1.3 1 0 0 1 1 1 1 Homeobox domain zf-ZPR1 PF03367.11 001171408.1_37923001_1 - 5.8e-112 370.6 0.1 9.5e-57 191.2 0.0 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain zinc-ribbons_6 PF07191.10 001171408.1_37923001_1 - 0.011 15.5 2.2 0.037 13.9 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbons HypA PF01155.17 001171408.1_37923001_1 - 0.016 15.1 3.8 0.27 11.1 0.6 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CpXC PF14353.4 001171408.1_37923001_1 - 0.027 14.3 2.8 1.7 8.6 1.9 3.1 3 1 0 3 3 3 0 CpXC protein Zn-ribbon_8 PF09723.8 001171408.1_37923001_1 - 0.036 14.0 4.8 12 6.0 0.1 3.7 4 0 0 4 4 4 0 Zinc ribbon domain zf-ribbon_3 PF13248.4 001171408.1_37923001_1 - 0.037 13.3 6.6 3.3 7.1 0.2 3.4 3 0 0 3 3 3 0 zinc-ribbon domain DUF983 PF06170.10 001171408.1_37923001_1 - 0.056 13.7 0.4 14 6.0 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF983) zf-RRPl_C4 PF17026.3 001171408.1_37923001_1 - 0.06 13.3 1.9 7.5 6.6 0.4 2.3 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type DUF1069 PF06370.9 001171408.1_37923001_1 - 0.12 11.8 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1069) Elf1 PF05129.11 001171408.1_37923001_1 - 0.17 11.8 0.9 3.7 7.5 0.2 2.5 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like DZR PF12773.5 001171408.1_37923001_1 - 0.36 10.8 7.1 2.1 8.3 2.7 3.3 3 1 0 3 3 3 0 Double zinc ribbon Ogr_Delta PF04606.10 001171408.1_37923001_1 - 0.54 10.2 6.2 0.052 13.4 1.4 1.8 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger GCFC PF07842.10 001171418.1_37926001_1 - 3.9e-35 121.7 0.5 9.8e-35 120.4 0.5 1.7 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein 7tm_1 PF00001.19 001171479.1_37923001_1 - 8.8e-66 221.7 8.0 1.2e-65 221.3 8.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171479.1_37923001_1 - 1.4e-06 27.8 0.7 2.4e-06 27.0 0.6 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx OppC_N PF12911.5 001171479.1_37923001_1 - 0.3 11.0 9.1 0.084 12.8 0.9 3.5 3 1 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C I-set PF07679.14 001171482.1_37929001_1 - 2.5e-164 533.7 0.0 6.3e-22 77.3 0.0 10.1 10 0 0 10 10 10 9 Immunoglobulin I-set domain Pkinase PF00069.23 001171482.1_37929001_1 - 4.8e-108 360.4 0.0 6.5e-54 182.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 001171482.1_37929001_1 - 2.8e-100 328.9 0.0 1.3e-11 44.8 0.0 10.3 11 0 0 11 11 9 9 Immunoglobulin domain Ig_2 PF13895.4 001171482.1_37929001_1 - 8e-62 205.4 0.0 2.3e-08 34.1 0.0 9.4 9 0 0 9 9 9 8 Immunoglobulin domain ig PF00047.23 001171482.1_37929001_1 - 2.8e-50 168.3 0.0 5.1e-06 26.4 0.0 10.7 10 1 0 10 10 10 8 Immunoglobulin domain Pkinase_Tyr PF07714.15 001171482.1_37929001_1 - 4.7e-50 170.1 0.0 1.8e-26 92.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase SPEG_u2 PF16650.3 001171482.1_37929001_1 - 2.4e-31 107.6 10.8 1.2e-30 105.4 9.7 3.0 2 0 0 2 2 1 1 Unstructured region on SPEG complex protein V-set PF07686.15 001171482.1_37929001_1 - 1.4e-16 60.4 5.2 0.05 13.6 0.0 10.9 10 4 1 11 11 9 4 Immunoglobulin V-set domain C2-set_2 PF08205.10 001171482.1_37929001_1 - 1e-15 57.4 1.8 0.29 11.1 0.0 8.3 9 0 0 9 9 8 3 CD80-like C2-set immunoglobulin domain fn3 PF00041.19 001171482.1_37929001_1 - 5.2e-09 36.2 0.0 0.0029 17.8 0.0 2.8 2 0 0 2 2 2 2 Fibronectin type III domain C1-set PF07654.13 001171482.1_37929001_1 - 3.3e-06 27.4 0.0 2.3 8.6 0.0 6.3 6 0 0 6 6 6 1 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 001171482.1_37929001_1 - 1.3e-05 25.0 1.8 1.2 9.1 0.1 6.9 8 0 0 8 8 8 1 Izumo-like Immunoglobulin domain Kdo PF06293.12 001171482.1_37929001_1 - 0.008 15.4 0.4 0.077 12.2 0.1 2.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Receptor_2B4 PF11465.6 001171482.1_37929001_1 - 0.015 15.4 0.0 19 5.4 0.0 5.0 7 0 0 7 7 7 0 Natural killer cell receptor 2B4 Kinase-like PF14531.4 001171482.1_37929001_1 - 0.028 13.6 0.0 0.091 11.9 0.0 1.8 2 0 0 2 2 2 0 Kinase-like Pox_ser-thr_kin PF05445.9 001171482.1_37929001_1 - 0.057 12.2 0.0 6.7 5.4 0.0 2.1 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase APH PF01636.21 001171482.1_37929001_1 - 0.075 12.8 6.6 0.3 10.8 0.1 4.1 3 1 0 3 3 3 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.7 001171482.1_37929001_1 - 0.25 10.7 0.0 0.91 8.9 0.0 1.8 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL zf-C2H2_assoc2 PF16624.3 001171278.1_37924001_1 - 1.8e-37 128.1 14.4 1.8e-37 128.1 14.4 4.1 4 2 1 5 5 2 1 Unstructured region upstream of a zinc-finger zf-C2H2_4 PF13894.4 001171278.1_37924001_1 - 1.5e-16 59.5 55.9 0.0031 18.1 2.0 7.7 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2 PF00096.24 001171278.1_37924001_1 - 3.1e-15 55.6 58.3 0.0021 18.3 1.6 7.7 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_11 PF16622.3 001171278.1_37924001_1 - 3.6e-14 52.1 11.8 4.6e-14 51.7 5.3 6.6 7 0 0 7 7 7 4 zinc-finger C2H2-type zf-C2H2_2 PF12756.5 001171278.1_37924001_1 - 9.1e-06 25.8 34.1 0.027 14.7 1.1 7.1 6 1 1 7 7 7 3 C2H2 type zinc-finger (2 copies) zf-met PF12874.5 001171278.1_37924001_1 - 8.3e-05 22.7 42.2 0.0021 18.3 0.7 6.9 7 0 0 7 7 6 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001171278.1_37924001_1 - 0.00051 20.2 1.4 0.00051 20.2 1.4 7.3 7 1 0 7 7 5 3 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 001171278.1_37924001_1 - 0.0008 19.0 0.8 0.0008 19.0 0.8 6.5 7 0 0 7 7 6 2 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.3 001171278.1_37924001_1 - 0.0009 19.4 0.9 0.0009 19.4 0.9 4.3 5 1 1 6 6 6 1 C2H2-type zinc ribbon zf-Di19 PF05605.10 001171278.1_37924001_1 - 0.0013 18.8 1.7 0.0013 18.8 1.7 6.0 6 0 0 6 6 5 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_9 PF16293.3 001171278.1_37924001_1 - 0.0027 17.4 10.7 7.3 6.4 0.0 5.0 5 0 0 5 5 5 1 C2H2 type zinc-finger (1 copy) zf-H2C2_2 PF13465.4 001171278.1_37924001_1 - 0.0082 16.4 0.5 0.0082 16.4 0.5 10.2 11 1 0 11 11 10 4 Zinc-finger double domain zf-C2H2_6 PF13912.4 001171278.1_37924001_1 - 0.052 13.4 0.7 0.052 13.4 0.7 6.6 7 0 0 7 7 7 0 C2H2-type zinc finger GRIP PF01465.18 001171279.1_37925001_1 - 1.7e-16 59.7 0.0 4.5e-16 58.4 0.0 1.8 1 0 0 1 1 1 1 GRIP domain LPP PF04728.11 001171279.1_37925001_1 - 0.00082 19.6 0.6 0.00082 19.6 0.6 6.0 6 2 1 7 7 7 1 Lipoprotein leucine-zipper DUF4203 PF13886.4 001171484.1_37923001_1 - 7.5e-47 159.5 31.0 9.1e-47 159.2 31.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) Serpin PF00079.18 001171288.1_37923001_1 - 1.5e-129 432.4 0.8 1.6e-129 432.3 0.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF1447 PF07288.9 001171288.1_37923001_1 - 0.02 14.8 0.4 0.07 13.1 0.4 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1447) DUF3873 PF12989.5 001171288.1_37923001_1 - 0.13 12.5 0.6 0.8 10.0 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3873) Copine PF07002.14 001171493.1_37924001_1 - 1.8e-86 289.0 0.0 3.3e-86 288.1 0.0 1.4 1 0 0 1 1 1 1 Copine C2 PF00168.28 001171493.1_37924001_1 - 3.5e-25 88.1 0.0 5.3e-12 45.8 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.7 001171493.1_37924001_1 - 1.9e-06 28.0 0.0 4e-06 27.0 0.0 1.5 2 0 0 2 2 2 1 vWA found in TerF C terminus VWA PF00092.26 001171493.1_37924001_1 - 0.00013 22.2 0.0 0.00089 19.4 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain CHD5 PF04420.12 001171290.1_37922001_1 - 9.5e-34 116.4 1.0 1.1e-33 116.2 1.0 1.1 1 0 0 1 1 1 1 CHD5-like protein DUF2203 PF09969.7 001171290.1_37922001_1 - 0.00017 22.2 0.5 0.041 14.5 0.1 2.1 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2203) DUF1043 PF06295.10 001171290.1_37922001_1 - 0.00048 20.0 0.3 0.00063 19.6 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) DUF2868 PF11067.6 001171290.1_37922001_1 - 0.0075 15.7 0.2 0.23 10.8 0.2 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2868) DUF4781 PF16013.3 001171290.1_37922001_1 - 0.026 13.2 0.0 0.039 12.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) Lys-AminoMut_A PF09043.9 001171290.1_37922001_1 - 0.084 11.2 0.5 0.1 10.9 0.5 1.0 1 0 0 1 1 1 0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit DUF2207 PF09972.7 001171290.1_37922001_1 - 0.11 11.1 0.3 0.14 10.8 0.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1640 PF07798.9 001171290.1_37922001_1 - 0.23 11.4 6.0 0.4 10.6 6.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) MCU PF04678.11 001171290.1_37922001_1 - 0.56 10.2 6.9 3.4 7.6 6.9 1.9 1 1 0 1 1 1 0 Mitochondrial calcium uniporter GIDA PF01134.20 001171292.1_37925001_1 - 1.5e-152 508.1 0.0 1.9e-152 507.8 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.4 001171292.1_37925001_1 - 9.6e-60 201.7 0.1 1.4e-59 201.2 0.1 1.2 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.5 001171292.1_37925001_1 - 1.1e-06 28.1 0.1 1.5e-06 27.7 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.12 001171292.1_37925001_1 - 4.3e-06 26.0 0.6 2.3e-05 23.7 0.7 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 001171292.1_37925001_1 - 4.7e-06 25.8 2.5 0.00011 21.4 1.5 2.1 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.19 001171292.1_37925001_1 - 0.00016 20.9 0.3 0.00035 19.8 0.1 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.12 001171292.1_37925001_1 - 0.0011 17.7 0.3 0.012 14.2 0.3 2.3 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.25 001171292.1_37925001_1 - 0.0042 17.5 0.1 0.011 16.2 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001171292.1_37925001_1 - 0.1 11.7 0.0 0.34 10.0 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 001171292.1_37925001_1 - 2.2 7.7 4.2 4.5 6.7 2.9 1.9 1 1 1 2 2 2 0 FAD dependent oxidoreductase CSTF_C PF14304.4 001171314.1_37929001_1 - 5.4 6.5 15.8 2.3 7.7 0.2 5.3 5 0 0 5 5 5 0 Transcription termination and cleavage factor C-terminal SF1-HH PF16275.3 001171327.1_37924001_1 - 3.7e-44 149.6 1.7 3.7e-44 149.6 1.7 2.1 2 0 0 2 2 2 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.27 001171327.1_37924001_1 - 1.6e-07 30.9 1.1 3.6e-07 29.8 1.1 1.6 1 1 0 1 1 1 1 KH domain zf-CCHC PF00098.21 001171327.1_37924001_1 - 0.0001 22.1 1.6 0.0002 21.1 1.6 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.4 001171327.1_37924001_1 - 0.019 14.5 1.3 0.11 12.2 0.8 2.5 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.4 001171327.1_37924001_1 - 0.06 13.2 0.2 0.13 12.1 0.2 1.5 1 0 0 1 1 1 0 Zinc knuckle UPF0181 PF03701.12 001171327.1_37924001_1 - 0.42 10.1 0.0 0.42 10.1 0.0 2.4 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0181) UDPGT PF00201.16 001195629.1_37924001_1 - 6.4e-230 764.0 0.1 7.5e-230 763.8 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001195629.1_37924001_1 - 1e-06 28.7 0.0 1.8e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_4_2 PF13477.4 001195629.1_37924001_1 - 0.1 12.5 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase 4-like Ribosomal_L4 PF00573.20 001195817.1_37923001_2 - 1.5e-40 138.8 0.1 2.7e-40 138.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.4 001195817.1_37923001_2 - 1.1e-30 105.3 8.7 1.1e-30 105.3 8.7 2.1 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain TGF_beta PF00019.18 001199117.1_37923001_1 - 3.8e-28 98.3 0.1 6.8e-28 97.5 0.1 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 001199117.1_37923001_1 - 0.0097 15.5 2.4 0.11 12.1 0.2 2.2 2 0 0 2 2 2 2 TGF-beta propeptide Paralemmin PF03285.13 001204216.1_37929001_1 - 1e-112 376.7 13.2 1.4e-112 376.3 13.2 1.2 1 0 0 1 1 1 1 Paralemmin CALCOCO1 PF07888.9 001204216.1_37929001_1 - 0.082 11.3 14.3 0.12 10.8 14.3 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Peptidase_S49_N PF08496.8 001204216.1_37929001_1 - 1.1 9.2 3.7 3.4 7.6 3.7 1.8 1 0 0 1 1 1 0 Peptidase family S49 N-terminal NDK PF00334.17 001204750.1_37922001_2 - 5.3e-56 188.2 0.0 6e-56 188.0 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase NDK PF00334.17 001204749.1_37921001_1 - 7.3e-55 184.5 0.0 8.3e-55 184.4 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Benyvirus_14KDa PF07255.9 001204749.1_37921001_1 - 0.029 14.4 0.0 0.045 13.9 0.0 1.3 1 0 0 1 1 1 0 Benyvirus 14KDa protein Adap_comp_sub PF00928.19 001204846.1_37925001_1 - 2.3e-61 207.3 0.1 4.2e-61 206.5 0.1 1.4 1 0 0 1 1 1 1 Adaptor complexes medium subunit family SUIM_assoc PF16619.3 001204846.1_37925001_1 - 0.042 13.8 0.1 0.31 11.0 0.0 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 7tm_1 PF00001.19 001205046.1_37925001_2 - 1.4e-17 63.7 13.6 2e-17 63.2 13.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ank_2 PF12796.5 001205047.1_37924001_1 - 2.9e-56 187.9 3.3 5e-18 65.3 0.1 5.4 2 2 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001205047.1_37924001_1 - 1.4e-45 153.0 6.4 3.9e-10 39.9 0.1 7.3 5 2 2 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.28 001205047.1_37924001_1 - 5.2e-39 130.9 10.5 2.5e-06 27.6 0.0 10.5 9 2 2 11 11 11 7 Ankyrin repeat Ank_3 PF13606.4 001205047.1_37924001_1 - 1.8e-36 119.9 6.1 8.3e-05 22.6 0.0 10.8 11 0 0 11 11 11 7 Ankyrin repeat Ank_5 PF13857.4 001205047.1_37924001_1 - 1.8e-28 98.0 5.7 1.2e-05 25.4 0.1 8.6 2 1 6 9 9 9 7 Ankyrin repeats (many copies) SOCS_box PF07525.14 001205047.1_37924001_1 - 1.1e-11 44.7 6.1 1.6e-11 44.2 4.7 2.0 2 0 0 2 2 2 1 SOCS box RRM_1 PF00076.20 001205257.1_37927001_3 - 8.7e-09 34.9 0.0 0.0014 18.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001205257.1_37927001_3 - 2.3e-05 23.9 0.2 0.018 14.5 0.0 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_jaz PF12171.6 001205257.1_37927001_3 - 0.018 15.2 8.8 1 9.6 1.1 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-U1 PF06220.10 001205257.1_37927001_3 - 7.9 6.2 7.2 0.41 10.3 0.5 2.1 2 0 0 2 2 2 0 U1 zinc finger Homeobox PF00046.27 001206424.1_37923001_1 - 7.1e-21 73.7 5.8 1.5e-20 72.6 5.8 1.6 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001206424.1_37923001_1 - 0.02 14.7 1.7 0.035 13.9 0.3 2.2 2 0 0 2 2 2 0 Homeobox KN domain AIRS_C PF02769.20 001145817.1_39727001_2 - 3.8e-30 104.9 0.1 5.3e-30 104.5 0.1 1.2 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.22 001145817.1_39727001_2 - 5e-10 39.8 0.3 1.1e-09 38.7 0.3 1.5 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain MRG PF05712.11 001253749.1_37924001_2 - 1.8e-54 184.0 0.7 2.8e-54 183.3 0.7 1.3 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.6 001253749.1_37924001_2 - 1.1e-15 57.1 0.4 2.1e-15 56.2 0.4 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain AIRS_C PF02769.20 001256961.1_37925001_3 - 7.5e-28 97.5 0.1 1.2e-27 96.8 0.1 1.3 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.22 001256961.1_37925001_3 - 1.1e-09 38.7 0.3 2.8e-09 37.4 0.3 1.7 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain Pyr_redox_2 PF07992.12 001256962.1_37924001_1 - 2.7e-55 187.5 0.4 3.3e-55 187.2 0.4 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 001256962.1_37924001_1 - 9e-28 96.6 0.0 2.3e-27 95.3 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 001256962.1_37924001_1 - 1.6e-18 66.9 3.7 5.3e-15 55.6 0.2 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001256962.1_37924001_1 - 3.3e-16 59.3 0.7 1e-11 44.6 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 001256962.1_37924001_1 - 1e-07 31.3 0.5 4.7e-07 29.1 0.3 2.1 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.12 001256962.1_37924001_1 - 3.2e-05 22.7 0.6 0.00022 19.9 0.1 2.0 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.5 001256962.1_37924001_1 - 6.1e-05 22.4 1.0 0.0001 21.6 1.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.19 001256962.1_37924001_1 - 7.3e-05 22.0 0.2 0.011 14.9 0.0 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.15 001256962.1_37924001_1 - 0.0003 20.0 0.3 0.0011 18.1 0.0 1.9 2 0 0 2 2 2 1 Thi4 family DAO PF01266.22 001256962.1_37924001_1 - 0.00047 19.7 0.4 0.0025 17.4 0.1 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.20 001256962.1_37924001_1 - 0.00066 18.7 0.4 0.0014 17.6 0.4 1.6 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.4 001256962.1_37924001_1 - 0.0014 18.7 0.3 0.0014 18.7 0.3 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.17 001256962.1_37924001_1 - 0.011 14.9 3.4 0.016 14.3 0.1 2.2 2 0 0 2 2 2 0 FAD binding domain NAD_binding_7 PF13241.4 001256962.1_37924001_1 - 0.016 15.5 0.7 2.8 8.3 0.1 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding Lycopene_cycl PF05834.10 001256962.1_37924001_1 - 0.065 12.1 0.0 0.13 11.2 0.0 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein adh_short_C2 PF13561.4 001277088.2_37922001_1 - 2.9e-59 200.3 0.0 3.9e-59 199.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 001277088.2_37922001_1 - 1e-48 165.2 0.1 1.2e-48 165.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 001277088.2_37922001_1 - 1.1e-10 41.6 0.9 1.6e-10 41.1 0.9 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.8 001277088.2_37922001_1 - 0.0024 17.2 0.0 0.0043 16.3 0.0 1.4 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) YjeF_N PF03853.13 001277088.2_37922001_1 - 0.0062 16.3 0.2 0.011 15.5 0.2 1.5 1 0 0 1 1 1 1 YjeF-related protein N-terminus NAD_binding_10 PF13460.4 001277088.2_37922001_1 - 0.017 14.9 0.6 0.027 14.3 0.6 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Epimerase PF01370.19 001277088.2_37922001_1 - 0.025 13.9 0.1 0.033 13.5 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DFP PF04127.13 001277088.2_37922001_1 - 0.043 13.5 0.3 0.1 12.3 0.3 1.6 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Helicase_RecD PF05127.12 001277088.2_37922001_1 - 0.13 11.9 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Helicase 7tm_1 PF00001.19 001278765.1_49823001_2 - 1.3e-29 103.2 14.1 1.4e-29 103.0 12.7 1.7 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001278765.1_49823001_2 - 5.6e-05 22.5 4.1 0.0073 15.5 4.1 2.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.7 001278765.1_49823001_2 - 0.00026 20.3 6.8 0.00036 19.9 6.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001278765.1_49823001_2 - 0.14 11.4 9.2 0.48 9.6 9.2 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.19 001278783.1_49823001_2 - 2.4e-16 59.7 0.0 4.2e-16 58.8 0.0 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Cytochrome_B PF00033.17 001278783.1_49823001_2 - 0.011 15.5 0.3 0.021 14.5 0.2 1.6 1 1 0 1 1 1 0 Cytochrome b/b6/petB Aldo_ket_red PF00248.19 001278867.1_37923001_1 - 1.9e-57 194.5 0.0 2.8e-57 194.0 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family CARD_2 PF16739.3 001279529.1_40424001_1 - 1.3e-19 69.8 0.0 2e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Caspase recruitment domain Radical_SAM PF04055.19 001279531.1_40423001_1 - 7.5e-16 58.8 0.1 3.4e-15 56.7 0.1 2.1 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.4 001279531.1_40423001_1 - 1.8e-08 34.4 0.5 9.8e-07 28.8 0.1 2.3 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.4 001279531.1_40423001_1 - 1.2e-07 32.0 0.2 2.1e-07 31.1 0.2 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain 7tm_1 PF00001.19 001280672.1_39524001_1 - 1.8e-45 155.1 32.4 2.8e-45 154.5 32.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MscS_TM PF12794.5 001280672.1_39524001_1 - 0.18 10.5 5.6 0.32 9.7 0.3 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 BAAT_C PF08840.9 001283932.1_29524001_2 - 2.1e-88 295.6 0.0 2.6e-88 295.3 0.0 1.1 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Bile_Hydr_Trans PF04775.12 001283932.1_29524001_2 - 2.8e-39 133.9 0.0 3.8e-39 133.4 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA thioester hydrolase/BAAT N-terminal region DLH PF01738.16 001283932.1_29524001_2 - 4.2e-05 23.1 0.7 0.0012 18.3 0.7 2.7 1 1 0 1 1 1 1 Dienelactone hydrolase family 7tm_1 PF00001.19 001285653.1_09024001_2 - 4.1e-28 98.2 5.7 1e-27 97.0 5.7 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001285653.1_09024001_2 - 0.0052 16.0 3.9 0.0065 15.7 3.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Ras PF00071.20 001285685.1_09022001_1 - 2.6e-57 192.8 0.0 3.3e-57 192.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001285685.1_09022001_1 - 2.6e-23 82.4 0.0 4e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001285685.1_09022001_1 - 1.7e-10 40.5 0.0 3.2e-10 39.6 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001285685.1_09022001_1 - 0.00013 21.4 0.0 0.00027 20.4 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001285685.1_09022001_1 - 0.029 14.1 0.0 0.13 12.0 0.0 2.0 2 1 0 2 2 2 0 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 001285685.1_09022001_1 - 0.037 13.3 0.0 0.056 12.7 0.0 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001285685.1_09022001_1 - 0.047 13.0 0.0 0.076 12.3 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Keratin_B2_2 PF13885.4 001285768.1_09022001_2 - 4.5e-05 23.2 96.0 7.8 6.4 50.6 5.0 1 1 1 2 2 2 1 Keratin, high sulfur B2 protein PMG PF05287.10 001285768.1_09022001_2 - 0.0089 15.9 45.5 0.026 14.5 45.5 1.8 1 1 0 1 1 1 1 PMG protein Ribosomal_S7e PF01251.16 001285834.1_37922001_2 - 1.5e-93 311.5 3.8 1.8e-93 311.3 3.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S7e Aldo_ket_red PF00248.19 001287557.1_37923001_1 - 3.2e-55 187.2 0.0 3.8e-55 187.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family ODC_AZ PF02100.15 001290017.1_24224001_1 - 7.8e-20 70.9 0.0 1.3e-19 70.2 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Hormone_1 PF00103.18 001173532.2_40422001_1 - 8e-56 189.0 0.3 1e-55 188.7 0.3 1.1 1 0 0 1 1 1 1 Somatotropin hormone family Hormone_1 PF00103.18 001290306.1_40423001_3 - 4e-55 186.8 0.3 4.9e-55 186.5 0.3 1.1 1 0 0 1 1 1 1 Somatotropin hormone family Asp_protease_2 PF13650.4 001291073.1_40429001_2 - 0.00079 19.9 0.0 0.0013 19.3 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001291073.1_40429001_2 - 0.016 15.0 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001291073.1_40429001_2 - 0.053 14.0 0.0 0.086 13.3 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.15 001291073.1_40429001_3 - 4.8e-15 55.5 1.9 1.9e-14 53.6 0.0 2.4 2 0 0 2 2 2 1 Retrotransposon gag protein DUF4939 PF16297.3 001291073.1_40429001_3 - 5.1e-15 55.2 0.0 9.4e-15 54.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Rootletin PF15035.4 001291073.1_40429001_3 - 0.00034 20.6 0.1 0.00067 19.7 0.1 1.4 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion KASH_CCD PF14662.4 001291073.1_40429001_3 - 0.0021 17.8 4.6 0.0035 17.1 4.6 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH zf-CCHC_5 PF14787.4 001291073.1_40429001_3 - 0.0029 17.1 0.2 0.0069 15.9 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Spc29 PF17082.3 001291073.1_40429001_3 - 0.0078 15.9 0.5 0.013 15.2 0.5 1.2 1 0 0 1 1 1 1 Spindle Pole Component 29 SlyX PF04102.10 001291073.1_40429001_3 - 0.3 11.6 2.4 0.71 10.4 2.4 1.7 1 0 0 1 1 1 0 SlyX CENP-H PF05837.10 001291073.1_40429001_3 - 0.41 10.9 4.7 0.85 9.9 4.7 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ZapB PF06005.10 001291073.1_40429001_3 - 0.59 10.5 9.7 1.4 9.3 9.7 1.6 1 0 0 1 1 1 0 Cell division protein ZapB CCDC106 PF15794.3 001291073.1_40429001_3 - 0.67 9.5 3.6 0.86 9.1 2.3 1.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 DUF972 PF06156.11 001291073.1_40429001_3 - 0.76 10.3 3.9 2 9.0 3.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF972) IncA PF04156.12 001291073.1_40429001_3 - 1.1 8.8 3.4 2.3 7.8 3.4 1.4 1 0 0 1 1 1 0 IncA protein DivIC PF04977.13 001291073.1_40429001_3 - 3.6 7.3 7.1 8.7 6.1 7.1 1.6 1 0 0 1 1 1 0 Septum formation initiator SHE3 PF17078.3 001291073.1_40429001_3 - 8.2 5.9 10.2 2.2 7.8 7.1 1.5 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 Orn_Arg_deC_N PF02784.14 001293719.1_40425001_1 - 9.2e-73 244.6 0.0 1.2e-72 244.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001293719.1_40425001_1 - 1.5e-20 73.2 0.0 2.5e-20 72.5 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 001293719.1_40425001_1 - 7.9e-06 25.3 0.0 1.6e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Orn_Arg_deC_N PF02784.14 001293723.1_24225001_1 - 1.7e-70 237.1 0.0 2.1e-70 236.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001293723.1_24225001_1 - 2e-19 69.6 0.0 3.4e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 001293723.1_24225001_1 - 0.00025 20.4 0.0 0.00048 19.5 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel ODC_AZ PF02100.15 001301419.1_24222001_3 - 5.4e-14 52.0 0.0 8.3e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Orn_Arg_deC_N PF02784.14 001291495.2_40429001_3 - 6e-64 215.7 0.2 7.6e-64 215.4 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001291495.2_40429001_3 - 2.9e-24 85.1 0.0 5.1e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain MHC_I PF00129.16 001305895.1_29723001_1 - 9.8e-92 305.3 1.2 1.4e-91 304.8 1.2 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001305895.1_29723001_1 - 7.2e-17 61.5 0.0 1.4e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001305895.1_29723001_1 - 2.9e-14 52.6 12.0 5.1e-14 51.8 12.0 1.4 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001305895.1_29723001_1 - 4e-05 24.0 0.5 0.0017 18.8 0.2 2.8 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001305895.1_29723001_1 - 9.9e-05 22.2 0.1 0.00022 21.1 0.1 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001305895.1_29723001_1 - 0.015 15.4 0.1 0.046 13.8 0.1 1.8 2 0 0 2 2 2 0 Immunoglobulin domain ig PF00047.23 001305904.1_29723001_1 - 1.2e-30 105.4 0.0 1.9e-11 43.8 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001305904.1_29723001_1 - 2.3e-18 66.2 0.1 5.8e-08 32.8 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 001305904.1_29723001_1 - 4.8e-16 59.0 0.0 0.00013 22.4 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001305904.1_29723001_1 - 6e-08 32.7 1.8 2.9 8.0 0.0 5.1 4 2 1 6 6 6 3 Immunoglobulin V-set domain Lep_receptor_Ig PF06328.9 001305904.1_29723001_1 - 0.087 12.7 0.0 5.6 6.9 0.0 2.9 3 0 0 3 3 3 0 Ig-like C2-type domain MHC_II_beta PF00969.17 001305925.1_29723001_2 - 1.9e-36 123.9 0.3 2.8e-36 123.4 0.3 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001305925.1_29723001_2 - 1.1e-25 89.8 0.2 2e-25 88.9 0.2 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001305925.1_29723001_2 - 2.6e-05 24.6 0.1 6.1e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001305925.1_29723001_2 - 6.1e-05 23.0 0.0 0.00011 22.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain DUF202 PF02656.13 001305925.1_29723001_2 - 0.073 13.4 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Ras PF00071.20 001308591.1_39524001_2 - 3.1e-51 173.0 0.0 4e-51 172.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001308591.1_39524001_2 - 1.3e-18 67.2 0.0 1.9e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001308591.1_39524001_2 - 1.1e-07 31.4 0.0 1.5e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PET117 PF15786.3 001308591.1_39524001_2 - 0.0014 18.7 0.0 0.0025 17.9 0.0 1.4 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial GTP_EFTU PF00009.25 001308591.1_39524001_2 - 0.13 11.7 0.0 0.37 10.2 0.0 1.7 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF2080 PF09853.7 001308591.1_39524001_3 - 0.032 13.8 0.0 0.054 13.1 0.0 1.3 1 0 0 1 1 1 0 Putative transposon-encoded protein (DUF2080) ig PF00047.23 001309027.1_29723001_1 - 1e-33 115.2 0.1 1.2e-13 50.9 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001309027.1_29723001_1 - 2.1e-22 79.1 0.3 1.4e-10 41.2 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 001309027.1_29723001_1 - 5.2e-17 62.1 1.2 1.7e-06 28.4 0.0 4.2 4 1 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 001309027.1_29723001_1 - 1.8e-09 37.6 0.4 0.42 10.7 0.0 4.6 4 1 1 5 5 5 3 Immunoglobulin V-set domain Lep_receptor_Ig PF06328.9 001309027.1_29723001_1 - 0.11 12.4 0.0 6.6 6.7 0.0 3.1 3 0 0 3 3 3 0 Ig-like C2-type domain TB PF00683.15 001309027.1_29723001_3 - 0.022 14.3 5.4 0.028 14.0 3.1 2.1 2 0 0 2 2 2 0 TB domain MHC_II_beta PF00969.17 001309030.1_29722001_1 - 5.5e-29 100.0 0.6 9.7e-29 99.2 0.6 1.4 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001309030.1_29722001_1 - 2.7e-27 94.9 0.1 1.2e-26 92.9 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001309030.1_29722001_1 - 0.00022 21.6 0.0 0.00075 19.9 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001309030.1_29722001_1 - 0.00066 19.7 0.0 0.0014 18.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001309030.1_29722001_1 - 0.0013 18.5 0.0 0.002 17.9 0.0 1.4 1 0 0 1 1 1 1 Marek's disease glycoprotein A Ig_2 PF13895.4 001309030.1_29722001_1 - 0.002 18.3 0.0 0.0048 17.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 001309030.1_29722001_1 - 0.0048 16.8 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001318349.1_29623001_1 - 2.9e-32 110.6 0.0 1.5e-13 50.6 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001318349.1_29623001_1 - 3.9e-21 75.1 0.0 1.7e-08 34.6 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 001318349.1_29623001_1 - 6.5e-17 61.8 0.0 6.9e-05 23.3 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001318349.1_29623001_1 - 4.4e-09 36.3 0.2 0.5 10.4 0.0 4.6 3 2 1 4 4 4 3 Immunoglobulin V-set domain DUF4721 PF15848.3 001318349.1_29623001_2 - 0.026 14.8 7.9 0.34 11.2 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4721) MHC_II_beta PF00969.17 001318352.1_29622001_1 - 3.7e-37 126.2 0.1 6.2e-37 125.5 0.1 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001318352.1_29622001_1 - 4.8e-27 94.1 0.2 2.1e-26 92.1 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001318352.1_29622001_1 - 1.7e-06 28.4 0.0 6.4e-06 26.6 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001318352.1_29622001_1 - 0.00041 20.3 0.1 0.0011 18.9 0.0 1.7 1 1 1 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 001318352.1_29622001_1 - 0.00079 19.3 0.1 0.0014 18.5 0.1 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain MHC_I PF00129.16 001318352.1_29622001_1 - 0.026 14.0 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_II_beta PF00969.17 001318344.1_29622001_1 - 3.4e-35 119.9 0.4 5.7e-35 119.2 0.4 1.4 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001318344.1_29622001_1 - 1.4e-25 89.4 0.2 3.2e-25 88.3 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001318344.1_29622001_1 - 2.3e-05 24.8 0.2 6.6e-05 23.3 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001318344.1_29622001_1 - 0.00033 20.6 0.3 0.00069 19.6 0.1 1.7 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001318344.1_29622001_1 - 0.0023 18.1 0.1 0.0042 17.3 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain DUF202 PF02656.13 001318344.1_29622001_1 - 0.066 13.5 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) I-set PF07679.14 001318344.1_29622001_1 - 0.11 12.4 0.0 0.37 10.8 0.0 1.8 1 1 0 1 1 1 0 Immunoglobulin I-set domain MHC_I_3 PF16497.3 001033114.2_29625001_3 - 8.4e-95 315.8 4.5 8.4e-95 315.8 4.5 1.6 2 0 0 2 2 2 1 MHC-I family domain C1-set PF07654.13 001033114.2_29625001_3 - 7.6e-10 39.0 0.0 1.6e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001033114.2_29625001_3 - 3.9e-05 23.1 0.1 5.9e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_3 PF13927.4 001033114.2_29625001_3 - 0.0048 17.3 0.5 0.59 10.6 0.1 2.8 2 1 1 3 3 3 1 Immunoglobulin domain WD40 PF00400.30 001257948.2_29628001_1 - 4.3e-47 157.0 32.4 4.8e-07 30.2 0.1 8.0 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.6 001257948.2_29628001_1 - 5.7e-14 51.5 13.6 0.035 12.6 0.1 6.6 2 1 4 7 7 7 6 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.5 001257948.2_29628001_1 - 1.9e-13 50.4 7.0 0.024 14.8 0.1 7.0 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.5 001257948.2_29628001_1 - 5.4e-13 48.5 1.2 1.1e-12 47.5 1.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001257948.2_29628001_1 - 9.5e-09 34.8 0.2 1.9e-08 33.8 0.2 1.6 1 0 0 1 1 1 1 F-box domain PQQ_2 PF13360.4 001257948.2_29628001_1 - 1.7e-05 24.4 2.5 0.00016 21.2 1.9 2.8 1 1 0 1 1 1 1 PQQ-like domain Ge1_WD40 PF16529.3 001257948.2_29628001_1 - 0.0019 17.1 10.0 1.5 7.5 0.2 4.8 1 1 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein CDtoxinA PF03498.12 001257948.2_29628001_1 - 0.0079 15.7 1.9 0.33 10.4 0.3 3.0 2 1 0 2 2 2 1 Cytolethal distending toxin A/C domain Hira PF07569.9 001257948.2_29628001_1 - 0.062 12.9 1.8 22 4.6 0.0 4.1 2 2 2 4 4 4 0 TUP1-like enhancer of split PALB2_WD40 PF16756.3 001257948.2_29628001_1 - 0.065 12.0 7.8 0.19 10.5 0.2 4.2 2 2 3 5 5 5 0 Partner and localizer of BRCA2 WD40 domain HSP70 PF00012.18 001257948.2_29628001_1 - 0.4 8.7 7.4 0.59 8.1 7.4 1.1 1 0 0 1 1 1 0 Hsp70 protein Nop14 PF04147.10 001257948.2_29628001_1 - 1.4 6.9 26.7 2 6.4 26.7 1.1 1 0 0 1 1 1 0 Nop14-like family TFIIF_alpha PF05793.10 001257948.2_29628001_1 - 2.1 6.7 22.1 3.3 6.1 22.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BUD22 PF09073.8 001257948.2_29628001_1 - 2.7 7.1 22.9 4.3 6.4 22.9 1.2 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.10 001257948.2_29628001_1 - 5.6 6.2 23.2 9.6 5.4 23.2 1.3 1 0 0 1 1 1 0 SDA1 RRN3 PF05327.9 001257948.2_29628001_1 - 6.5 5.0 12.9 10 4.4 12.9 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 ABC_membrane PF00664.21 001032847.2_29629001_3 - 1.1e-74 251.4 39.7 1.3e-42 146.3 13.7 3.3 3 1 1 4 4 4 2 ABC transporter transmembrane region ABC_tran PF00005.25 001032847.2_29629001_3 - 4.4e-50 169.6 2.0 6.3e-26 91.4 0.0 3.7 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.17 001032847.2_29629001_3 - 1.6e-10 40.7 0.2 0.0096 15.2 0.0 4.4 2 2 2 4 4 4 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.21 001032847.2_29629001_3 - 3.6e-07 30.1 0.6 0.028 14.4 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.4 001032847.2_29629001_3 - 1e-06 29.1 0.1 0.15 12.3 0.0 3.3 2 1 0 3 3 3 2 AAA ATPase domain DUF258 PF03193.14 001032847.2_29629001_3 - 1.5e-05 24.9 1.7 0.034 13.9 0.0 2.8 3 0 0 3 3 2 2 Protein of unknown function, DUF258 AAA_29 PF13555.4 001032847.2_29629001_3 - 7.2e-05 22.3 0.4 0.037 13.6 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain Dynamin_N PF00350.21 001032847.2_29629001_3 - 0.00015 21.7 3.5 0.093 12.6 0.0 3.5 3 0 0 3 3 3 2 Dynamin family ArgK PF03308.14 001032847.2_29629001_3 - 0.00078 18.4 0.2 0.01 14.7 0.1 2.2 2 0 0 2 2 2 1 ArgK protein AAA_21 PF13304.4 001032847.2_29629001_3 - 0.0075 16.0 3.2 1.9 8.1 0.0 3.7 2 2 2 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.18 001032847.2_29629001_3 - 0.01 14.8 0.0 2 7.2 0.0 2.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_30 PF13604.4 001032847.2_29629001_3 - 0.016 14.8 1.5 4.2 6.9 0.2 3.6 3 1 0 3 3 3 0 AAA domain RNA_helicase PF00910.20 001032847.2_29629001_3 - 0.025 14.8 0.6 36 4.7 0.0 3.6 3 0 0 3 3 3 0 RNA helicase AAA_PrkA PF08298.9 001032847.2_29629001_3 - 0.025 13.3 0.0 0.43 9.3 0.0 2.2 2 0 0 2 2 2 0 PrkA AAA domain AAA_22 PF13401.4 001032847.2_29629001_3 - 0.03 14.5 6.4 1.5 8.9 0.0 3.9 4 1 0 4 4 3 0 AAA domain AAA_24 PF13479.4 001032847.2_29629001_3 - 0.046 13.3 0.0 3.5 7.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.11 001032847.2_29629001_3 - 0.049 12.7 0.1 5.2 6.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Guanylate_kin PF00625.19 001032847.2_29629001_3 - 0.12 11.9 0.1 1.3 8.5 0.0 2.4 2 0 0 2 2 2 0 Guanylate kinase Zeta_toxin PF06414.10 001032847.2_29629001_3 - 0.28 10.3 4.3 6.6 5.8 0.0 2.9 3 0 0 3 3 3 0 Zeta toxin DUF87 PF01935.15 001032847.2_29629001_3 - 4.9 7.0 14.5 0.22 11.4 0.2 3.6 4 0 0 4 4 4 0 Domain of unknown function DUF87 ATP_bind_1 PF03029.15 001032847.2_29629001_3 - 7.2 6.2 9.5 2.8 7.5 0.1 3.2 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein Tetraspannin PF00335.18 001244196.1_49824001_2 - 5.8e-46 156.8 13.1 7.6e-46 156.4 13.1 1.1 1 0 0 1 1 1 1 Tetraspanin family NfeD PF01957.16 001244196.1_49824001_2 - 0.3 11.4 3.2 0.2 11.9 0.6 2.0 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding SUR7 PF06687.10 001244196.1_49824001_2 - 0.63 9.5 10.9 0.21 11.1 2.5 2.7 3 0 0 3 3 3 0 SUR7/PalI family IncA PF04156.12 001244196.1_49824001_2 - 1.1 8.9 4.0 0.36 10.5 0.8 1.8 2 0 0 2 2 2 0 IncA protein MAGE_N PF12440.6 001206775.1_06524001_2 - 1.2e-14 54.6 13.6 2.6e-14 53.5 13.6 1.6 1 0 0 1 1 1 1 Melanoma associated antigen family N terminal MAGE PF01454.17 001206775.1_06524001_2 - 7.4e-13 48.5 1.0 1.8e-07 30.9 0.0 2.6 2 1 1 3 3 3 2 MAGE family DUF1180 PF06679.10 001206775.1_06524001_2 - 0.023 15.0 1.1 0.041 14.2 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF4680 PF15730.3 001206775.1_06524001_2 - 7.6 6.7 10.0 42 4.3 10.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4680) MHC_II_alpha PF00993.18 001308592.1_39522001_3 - 1.6e-38 130.2 0.0 2.3e-38 129.6 0.0 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001308592.1_39522001_3 - 2.3e-28 97.2 1.2 4.7e-28 96.2 1.2 1.5 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001308592.1_39522001_3 - 5.1e-24 84.4 0.0 8e-24 83.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001308592.1_39522001_3 - 4.6e-07 30.2 0.0 7.8e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001308592.1_39522001_3 - 0.0013 18.5 0.1 0.0019 18.0 0.1 1.1 1 0 0 1 1 1 1 Marek's disease glycoprotein A Ig_2 PF13895.4 001308592.1_39522001_3 - 0.0025 18.0 0.0 0.0051 17.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001308592.1_39522001_3 - 0.0058 16.5 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain SKG6 PF08693.8 001308592.1_39522001_3 - 0.3 10.4 2.5 0.58 9.5 2.5 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain GRAM PF02893.18 001285167.1_29524001_2 - 6.3e-15 54.9 0.0 1.8e-14 53.4 0.0 1.6 2 0 0 2 2 2 1 GRAM domain Vps36_ESCRT-II PF11605.6 001285167.1_29524001_2 - 0.00048 20.1 0.0 0.00075 19.5 0.0 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 zf-met PF12874.5 001285109.1_29525001_1 - 8.1e-23 80.0 15.3 1.7e-08 34.4 1.8 3.5 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001285109.1_29525001_1 - 1.9e-15 56.6 13.0 5.4e-05 23.3 1.8 3.5 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 001285109.1_29525001_1 - 4.4e-07 30.0 4.0 0.47 10.7 0.2 3.2 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.10 001285109.1_29525001_1 - 0.00039 20.6 2.7 0.63 10.1 0.1 3.2 3 0 0 3 3 3 1 A-kinase anchoring protein 95 (AKAP95) zf-U1 PF06220.10 001285109.1_29525001_1 - 0.00054 19.5 5.0 0.16 11.6 0.0 3.3 3 0 0 3 3 3 1 U1 zinc finger zf-C2H2 PF00096.24 001285109.1_29525001_1 - 0.0019 18.4 9.1 0.76 10.2 0.2 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-DBF PF07535.10 001285109.1_29525001_1 - 0.0027 17.6 6.6 0.034 14.1 0.2 3.9 4 0 0 4 4 4 1 DBF zinc finger zf-C2H2_4 PF13894.4 001285109.1_29525001_1 - 0.0087 16.7 4.1 1.3 9.9 0.3 3.7 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_9 PF16293.3 001285109.1_29525001_1 - 0.067 12.9 3.5 8.2 6.2 0.1 3.1 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zinc_ribbon_15 PF17032.3 001285109.1_29525001_1 - 0.083 13.5 0.1 11 6.7 0.0 2.4 2 1 0 2 2 2 0 zinc-ribbon family DUF3449 PF11931.6 001285109.1_29525001_1 - 0.43 10.2 1.1 9.1 5.9 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) Actin_micro PF17003.3 001285109.1_29525001_1 - 0.9 8.5 2.7 17 4.3 0.0 2.7 3 0 0 3 3 3 0 Putative actin-like family MAGE PF01454.17 001283774.1_29524001_1 - 8.8e-19 67.9 0.0 7.1e-13 48.6 0.0 2.1 1 1 1 2 2 2 2 MAGE family Heme_oxygenase PF01126.18 001284683.1_29523001_2 - 6.7e-82 274.1 0.9 8.3e-82 273.8 0.9 1.1 1 0 0 1 1 1 1 Heme oxygenase EF-hand_4 PF12763.5 001283435.1_29528001_1 - 1.5e-17 63.3 0.0 3.4e-17 62.2 0.0 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EHD_N PF16880.3 001283435.1_29528001_1 - 1e-15 57.1 1.0 1e-15 57.1 1.0 2.1 2 0 0 2 2 2 1 N-terminal EH-domain containing protein Dynamin_N PF00350.21 001283435.1_29528001_1 - 1.2e-12 48.1 0.0 4.1e-12 46.4 0.0 1.8 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.21 001283435.1_29528001_1 - 5.7e-07 29.5 0.0 1.1e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase EF-hand_1 PF00036.30 001283435.1_29528001_1 - 0.031 13.7 0.0 0.074 12.5 0.0 1.6 1 0 0 1 1 1 0 EF hand HAUS4 PF14735.4 001283387.1_29524001_2 - 1.9e-83 279.6 18.9 1.9e-83 279.6 18.9 1.5 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 4 HCMV_UL139 PF12507.6 001283387.1_29524001_2 - 0.1 12.9 4.9 0.21 11.8 4.9 1.5 1 0 0 1 1 1 0 Human Cytomegalovirus UL139 protein SNAPc19 PF15497.4 001283416.1_29524001_3 - 1.6e-22 79.6 14.0 3.5e-22 78.5 14.0 1.5 1 0 0 1 1 1 1 snRNA-activating protein complex subunit 19, SNAPc subunit 19 HMG_box PF00505.17 001283545.1_29524001_1 - 3.7e-20 72.0 2.9 2.8e-09 37.1 0.2 3.4 3 0 0 3 3 3 3 HMG (high mobility group) box Sox17_18_mid PF12067.6 001283545.1_29524001_1 - 2.9e-19 68.7 4.5 9.1e-19 67.1 3.0 2.4 2 0 0 2 2 2 1 Sox 17/18 central domain HMG_box_2 PF09011.8 001283545.1_29524001_1 - 1.3e-06 28.7 0.2 0.0096 16.4 0.0 2.6 2 0 0 2 2 2 2 HMG-box domain 5TM-5TMR_LYT PF07694.10 001283633.1_29525001_2 - 4.8 6.5 25.2 0.73 9.2 9.3 3.5 2 1 1 3 3 3 0 5TMR of 5TMR-LYT KRAB PF01352.25 001283092.1_29524001_3 - 9.1e-24 82.7 0.2 2.1e-23 81.6 0.2 1.7 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 001283092.1_29524001_3 - 2.7e-22 78.0 42.5 5.6e-10 39.1 0.9 5.8 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.24 001283092.1_29524001_3 - 3.6e-17 61.6 31.5 1e-05 25.6 2.2 5.0 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001283092.1_29524001_3 - 1.9e-11 43.6 28.6 0.00094 19.7 1.4 5.1 4 0 0 4 4 4 4 C2H2-type zinc finger XPA_N PF01286.16 001283092.1_29524001_3 - 0.0018 18.1 8.5 7.9 6.5 0.1 4.6 4 0 0 4 4 4 1 XPA protein N-terminal zf-C2H2_11 PF16622.3 001283092.1_29524001_3 - 0.0073 15.9 0.7 0.0073 15.9 0.7 4.5 5 0 0 5 5 5 2 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 001283092.1_29524001_3 - 0.0082 15.9 35.9 0.0086 15.9 1.8 5.6 6 0 0 6 6 6 2 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 001283092.1_29524001_3 - 0.0083 16.7 0.7 0.0083 16.7 0.7 3.6 1 1 2 3 3 3 1 zinc-ribbon family zf-C2H2_jaz PF12171.6 001283092.1_29524001_3 - 0.011 15.9 0.8 0.011 15.9 0.8 5.1 5 1 1 6 6 4 0 Zinc-finger double-stranded RNA-binding zf-trcl PF13451.4 001283092.1_29524001_3 - 0.03 14.1 6.7 2.3 8.0 0.4 3.7 3 0 0 3 3 3 0 Probable zinc-ribbon domain Zn-ribbon_8 PF09723.8 001283092.1_29524001_3 - 0.088 12.8 19.6 1.6 8.8 5.4 4.4 1 1 4 5 5 5 0 Zinc ribbon domain PKI PF02827.14 001283092.1_29524001_3 - 1.4 9.0 7.2 5.7 7.1 0.1 2.8 3 0 0 3 3 2 0 cAMP-dependent protein kinase inhibitor Zn_Tnp_IS1595 PF12760.5 001283092.1_29524001_3 - 2.1 8.3 19.1 1.5 8.7 3.8 3.5 1 1 2 3 3 3 0 Transposase zinc-ribbon domain zf-BED PF02892.13 001283092.1_29524001_3 - 3 7.9 25.8 0.63 10.0 1.6 4.0 1 1 3 4 4 4 0 BED zinc finger zf-RING_7 PF02591.13 001283092.1_29524001_3 - 4.4 7.5 6.7 12 6.1 1.2 3.4 3 0 0 3 3 3 0 C4-type zinc ribbon domain zf-C2HE PF16278.3 001283092.1_29524001_3 - 5.3 7.4 22.1 0.32 11.4 4.5 4.1 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger YhfH PF14149.4 001283092.1_29524001_3 - 6.7 6.6 15.6 1.9 8.4 0.3 4.5 4 0 0 4 4 4 0 YhfH-like protein zf-C2HC_2 PF13913.4 001283092.1_29524001_3 - 7.5 6.5 15.4 2.1 8.2 0.3 4.3 4 0 0 4 4 4 0 zinc-finger of a C2HC-type p450 PF00067.20 001319506.1_29524001_2 - 1.2e-104 350.5 0.0 1.4e-104 350.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3216 PF11505.6 001319506.1_29524001_2 - 0.0073 16.5 0.3 3.4 7.9 0.1 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF3216) PKD PF00801.18 001319557.1_29526001_2 - 5.4e-11 42.0 0.0 2.8e-10 39.7 0.0 2.3 1 0 0 1 1 1 1 PKD domain COesterase PF00135.26 001319370.1_29524001_1 - 5.8e-180 599.4 0.0 6.7e-180 599.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family AChE_tetra PF08674.8 001319370.1_29524001_1 - 2.7e-22 78.0 9.0 7e-22 76.7 9.0 1.8 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain Abhydrolase_3 PF07859.11 001319370.1_29524001_1 - 2.4e-07 30.7 0.1 4.3e-07 29.8 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold WSK PF03832.11 001319462.1_29525001_3 - 1.4e-12 46.9 2.2 1.4e-12 46.9 2.2 4.9 5 0 0 5 5 5 1 WSK motif p450 PF00067.20 001319492.1_29524001_1 - 7.7e-138 460.0 0.0 9.1e-138 459.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Diacid_rec PF05651.11 001319492.1_29524001_1 - 0.078 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Putative sugar diacid recognition JmjC PF02373.20 001319500.1_29525001_2 - 1.1e-43 148.2 0.0 1.9e-43 147.4 0.0 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.15 001319500.1_29525001_2 - 1.1e-12 47.6 0.0 2.2e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 jmjN domain zf-H2C2_2 PF13465.4 001319640.1_29524001_2 - 5.4e-67 219.3 64.4 3.5e-10 39.7 2.4 11.7 11 0 0 11 11 11 8 Zinc-finger double domain zf-C2H2 PF00096.24 001319640.1_29524001_2 - 6.5e-46 152.2 86.1 1e-06 28.7 0.6 12.5 12 1 0 12 12 12 8 Zinc finger, C2H2 type KRAB PF01352.25 001319640.1_29524001_2 - 8.3e-26 89.3 0.3 1.3e-25 88.6 0.3 1.3 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 001319640.1_29524001_2 - 2.3e-24 83.8 80.3 0.0012 19.4 3.8 12.4 12 1 0 12 12 12 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001319640.1_29524001_2 - 5.1e-21 74.0 59.1 1.2e-05 24.9 0.5 10.0 9 1 0 9 9 9 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001319640.1_29524001_2 - 3.9e-13 49.2 44.7 0.01 16.0 0.4 10.1 10 0 0 10 10 10 6 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 001319640.1_29524001_2 - 1.7e-07 30.7 37.3 0.041 13.5 0.0 9.8 9 1 0 9 9 9 3 zinc-finger C2H2-type XPA_N PF01286.16 001319640.1_29524001_2 - 0.00027 20.8 38.4 2 8.4 0.2 9.0 9 0 0 9 9 9 3 XPA protein N-terminal zf-trcl PF13451.4 001319640.1_29524001_2 - 0.002 17.8 28.0 1.5 8.6 2.7 7.7 7 1 0 7 7 7 1 Probable zinc-ribbon domain Zn-ribbon_8 PF09723.8 001319640.1_29524001_2 - 0.003 17.5 46.9 0.014 15.4 3.8 7.4 5 2 5 10 10 10 5 Zinc ribbon domain C1_1 PF00130.20 001319640.1_29524001_2 - 0.025 14.3 35.1 0.47 10.2 1.1 6.8 3 1 5 8 8 8 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-LYAR PF08790.9 001319640.1_29524001_2 - 0.039 13.7 40.9 0.82 9.5 0.4 9.4 10 0 0 10 10 10 0 LYAR-type C2HC zinc finger zinc_ribbon_15 PF17032.3 001319640.1_29524001_2 - 0.051 14.2 43.1 0.21 12.2 1.7 6.1 2 2 5 7 7 7 0 zinc-ribbon family zf-met PF12874.5 001319640.1_29524001_2 - 0.46 10.8 68.1 0.1 12.9 0.9 10.4 12 0 0 12 12 11 0 Zinc-finger of C2H2 type YhfH PF14149.4 001319640.1_29524001_2 - 0.46 10.4 28.3 15 5.6 0.1 8.3 8 0 0 8 8 8 0 YhfH-like protein zf-C2HE PF16278.3 001319640.1_29524001_2 - 2.8 8.3 45.3 1.7 9.0 0.1 8.8 4 2 3 7 7 7 0 C2HE / C2H2 / C2HC zinc-binding finger DUF1163 PF06651.9 001319640.1_29524001_2 - 7.1 6.7 9.8 0.75 9.8 0.1 3.7 1 1 1 3 3 3 0 Protein of unknown function (DUF1163) Ank_2 PF12796.5 001319363.1_29524001_2 - 1.4e-41 140.8 3.8 3.9e-13 49.7 0.0 3.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.4 001319363.1_29524001_2 - 1.3e-24 83.5 1.1 0.0011 19.1 0.0 6.5 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.28 001319363.1_29524001_2 - 1.7e-22 78.6 5.5 0.0001 22.4 0.1 6.5 5 1 1 6 6 6 5 Ankyrin repeat Ank_5 PF13857.4 001319363.1_29524001_2 - 2e-21 75.6 2.6 6.5e-06 26.2 0.0 5.4 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank_4 PF13637.4 001319363.1_29524001_2 - 4.4e-20 71.7 2.1 2.6e-06 27.7 0.1 4.5 2 1 3 5 5 5 4 Ankyrin repeats (many copies) SOCS_box PF07525.14 001319363.1_29524001_3 - 4e-09 36.5 3.5 4e-09 36.5 3.5 2.2 2 0 0 2 2 2 1 SOCS box MatE PF01554.16 001319494.1_29524001_1 - 4.6e-60 201.8 29.0 1.3e-30 106.1 9.5 2.7 2 0 0 2 2 2 2 MatE MHC_I PF00129.16 001319488.1_29523001_1 - 2.1e-95 317.3 2.5 2.9e-95 316.8 2.5 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001319488.1_29523001_1 - 3.8e-17 62.4 0.1 9.5e-17 61.1 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001319488.1_29523001_1 - 1.2e-13 50.6 8.5 2e-13 49.9 8.5 1.4 1 0 0 1 1 1 1 MHC_I C-terminus C2-set_2 PF08205.10 001319488.1_29523001_1 - 0.00029 20.7 1.7 0.0004 20.3 0.1 1.9 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001319488.1_29523001_1 - 0.00094 19.2 0.0 0.0025 17.8 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Xlink PF00193.15 001319442.1_29524001_1 - 2e-61 204.3 0.0 1e-32 112.3 0.0 2.3 2 0 0 2 2 2 2 Extracellular link domain V-set PF07686.15 001319442.1_29524001_1 - 1.1e-09 38.2 0.0 2.2e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001319442.1_29524001_1 - 0.00011 22.7 0.0 0.00025 21.5 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001319442.1_29524001_1 - 0.0028 17.8 0.0 0.043 14.0 0.0 2.2 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001319442.1_29524001_1 - 0.0049 16.8 0.0 0.0095 15.8 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 001319442.1_29524001_1 - 0.026 14.6 0.0 0.094 12.8 0.0 1.9 1 1 0 1 1 1 0 Immunoglobulin domain Myf5 PF12232.6 001319577.1_37924001_3 - 1.2e-25 89.9 13.5 1.2e-25 89.9 13.5 2.4 2 0 0 2 2 2 1 Myogenic determination factor 5 Basic PF01586.14 001319577.1_37924001_3 - 2.7e-22 79.6 0.4 7.3e-22 78.2 0.4 1.8 1 0 0 1 1 1 1 Myogenic Basic domain HLH PF00010.24 001319577.1_37924001_3 - 9.4e-15 54.2 4.5 1.6e-14 53.4 4.5 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain 7tm_1 PF00001.19 001319275.1_22424001_3 - 2.5e-15 56.3 0.0 4.7e-15 55.4 0.0 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) P53 PF00870.16 204351.1_23524001_1 - 1.4e-109 364.1 1.9 1.4e-109 364.1 0.4 1.8 2 0 0 2 2 2 1 P53 DNA-binding domain P53_tetramer PF07710.9 204351.1_23524001_1 - 7.3e-17 60.3 0.1 2.2e-16 58.7 0.1 1.8 2 0 0 2 2 2 1 P53 tetramerisation motif SAM_2 PF07647.15 204351.1_23524001_1 - 2.6e-10 40.1 0.0 4.7e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 204351.1_23524001_1 - 0.015 15.6 0.0 0.036 14.4 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) EGF_CA PF07645.13 001326496.1_23525001_3 - 6.1e-16 58.2 41.0 2.1e-08 34.1 7.6 5.4 5 1 0 5 5 5 3 Calcium-binding EGF domain cEGF PF12662.5 001326496.1_23525001_3 - 4e-13 48.9 6.0 1.3e-11 44.0 1.9 5.4 5 0 0 5 5 5 2 Complement Clr-like EGF-like EGF PF00008.25 001326496.1_23525001_3 - 2.7e-12 46.6 15.6 2.6e-09 37.1 8.4 5.8 6 0 0 6 6 6 2 EGF-like domain Sushi PF00084.18 001326496.1_23525001_3 - 3.2e-12 46.7 7.4 2.6e-11 43.8 0.7 3.0 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) FXa_inhibition PF14670.4 001326496.1_23525001_3 - 2.8e-09 37.0 3.4 2.8e-09 37.0 3.4 6.0 6 0 0 6 6 6 2 Coagulation Factor Xa inhibitory site EGF_2 PF07974.11 001326496.1_23525001_3 - 0.0003 21.0 10.0 0.0003 21.0 10.0 6.5 7 0 0 7 7 7 2 EGF-like domain hEGF PF12661.5 001326496.1_23525001_3 - 0.015 15.8 8.7 0.015 15.8 8.7 6.1 6 0 0 6 6 6 0 Human growth factor-like EGF EGF_3 PF12947.5 001326496.1_23525001_3 - 3.1 7.9 34.8 0.13 12.3 0.5 5.7 6 0 0 6 6 6 0 EGF domain Amidase_2 PF01510.23 001044686.2_23523001_1 - 2.3e-10 40.9 0.0 3.7e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase HLH PF00010.24 001293112.1_02222001_1 - 1.8e-17 62.9 0.3 3.2e-17 62.1 0.3 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF773 PF05600.10 001293112.1_02222001_1 - 0.019 13.6 0.3 0.025 13.2 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF773) Dscam_C PF12355.6 001293112.1_02222001_1 - 7.2 7.5 16.1 13 6.7 14.1 2.2 1 1 1 2 2 2 0 Down syndrome cell adhesion molecule C terminal Glyco_transf_29 PF00777.16 001293129.1_02223001_1 - 6.9e-37 127.1 0.1 1.9e-36 125.7 0.0 1.6 1 1 1 2 2 2 1 Glycosyltransferase family 29 (sialyltransferase) PNPase_C PF12111.6 001293129.1_02223001_1 - 0.49 9.7 2.1 0.8 9.1 0.4 2.2 2 0 0 2 2 2 0 Polyribonucleotide phosphorylase C terminal Guanylate_kin PF00625.19 001291395.1_02225001_3 - 3e-47 160.5 0.2 5.1e-47 159.8 0.2 1.4 1 0 0 1 1 1 1 Guanylate kinase VGCC_beta4Aa_N PF12052.6 001291395.1_02225001_3 - 6.5e-22 77.2 6.1 1.6e-21 76.0 6.1 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal SH3_1 PF00018.26 001291395.1_02225001_3 - 0.0025 17.2 0.0 0.008 15.6 0.0 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 001291395.1_02225001_3 - 0.018 14.7 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain SH3_2 PF07653.15 001291395.1_02225001_3 - 0.044 13.4 0.0 0.096 12.3 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain zf-AN1 PF01428.14 001293125.1_02227001_1 - 6.6e-08 32.5 7.9 2.2e-07 30.8 7.9 2.0 1 0 0 1 1 1 1 AN1-like Zinc finger zf-A20 PF01754.14 001293125.1_02227001_1 - 8.1e-05 22.3 6.5 8.1e-05 22.3 6.5 2.4 2 0 0 2 2 2 1 A20-like zinc finger Ion_trans PF00520.29 001293124.1_02229001_1 - 4.7e-257 847.9 106.0 2.6e-80 269.0 17.6 4.2 4 0 0 4 4 4 4 Ion transport protein Na_trans_cytopl PF11933.6 001293124.1_02229001_1 - 1.3e-68 231.0 4.7 3.3e-68 229.6 4.7 1.7 1 0 0 1 1 1 1 Cytoplasmic domain of voltage-gated Na+ ion channel Na_trans_assoc PF06512.11 001293124.1_02229001_1 - 2.4e-56 190.9 2.0 2.4e-56 190.9 2.0 3.0 2 1 0 2 2 2 1 Sodium ion transport-associated PKD_channel PF08016.10 001293124.1_02229001_1 - 1.8e-08 33.4 84.1 0.0004 19.1 0.2 9.9 6 4 4 10 10 10 7 Polycystin cation channel GPHH PF16905.3 001293124.1_02229001_1 - 1.3e-05 24.8 0.0 3e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated IQ PF00612.25 001293124.1_02229001_1 - 0.018 14.7 0.6 0.048 13.3 0.6 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif Lustrin_cystein PF14625.4 001293124.1_02229001_1 - 0.087 13.1 0.7 0.29 11.4 0.7 1.8 1 0 0 1 1 1 0 Lustrin, cysteine-rich repeated domain TMEM51 PF15345.4 001293124.1_02229001_1 - 0.7 9.6 8.2 4.8 6.8 0.5 2.7 2 0 0 2 2 2 0 Transmembrane protein 51 Tmemb_9 PF05434.9 001293124.1_02229001_1 - 3.5 7.3 6.1 18 5.0 0.1 3.9 4 0 0 4 4 4 0 TMEM9 FLO_LFY PF01698.14 001293124.1_02229001_1 - 9.6 5.2 12.2 25 3.8 12.2 1.6 1 0 0 1 1 1 0 Floricaula / Leafy protein Glyco_transf_29 PF00777.16 001293128.1_02224001_1 - 1.9e-37 129.0 0.0 4.6e-37 127.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) U1snRNP70_N PF12220.6 001293128.1_02224001_1 - 0.11 13.0 0.9 0.24 11.9 0.9 1.5 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF3108 PF11306.6 001293128.1_02224001_1 - 0.16 11.8 0.3 0.24 11.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3108) Med29 PF11568.6 001294141.1_02222001_1 - 1e-40 139.1 0.2 1.2e-40 138.9 0.2 1.0 1 0 0 1 1 1 1 Mediator complex subunit 29 Pkinase PF00069.23 001281714.1_02224001_3 - 8.6e-67 225.1 0.0 1.1e-66 224.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Ras PF00071.20 001281714.1_02224001_3 - 6.2e-26 90.8 0.0 8.9e-26 90.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Pkinase_Tyr PF07714.15 001281714.1_02224001_3 - 5.6e-24 84.7 0.0 7.6e-24 84.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Roc PF08477.11 001281714.1_02224001_3 - 3.7e-21 75.5 0.0 6.6e-21 74.6 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001281714.1_02224001_3 - 1.7e-06 27.5 0.0 2.5e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001281714.1_02224001_3 - 0.0011 18.9 0.0 0.002 18.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Kinase-like PF14531.4 001281714.1_02224001_3 - 0.0012 18.1 0.0 0.007 15.6 0.0 1.8 1 1 1 2 2 2 1 Kinase-like APH PF01636.21 001281714.1_02224001_3 - 0.0057 16.5 0.0 0.016 15.0 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.12 001281714.1_02224001_3 - 0.031 13.5 0.0 0.048 12.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.14 001281714.1_02224001_3 - 0.084 12.9 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 ABC1 family RNase_H PF00075.22 001286008.1_02223001_3 - 2.8e-44 150.7 0.1 5.1e-44 149.8 0.1 1.4 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.14 001286008.1_02223001_3 - 8.6e-19 67.5 3.9 1.9e-18 66.4 3.9 1.6 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.4 001286008.1_02223001_3 - 0.0012 18.4 0.0 0.0074 15.9 0.0 2.2 3 0 0 3 3 3 1 Reverse transcriptase-like COesterase PF00135.26 001291390.1_02226001_1 - 2e-198 660.3 0.0 2.5e-198 660.0 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001291390.1_02226001_1 - 3.2e-07 30.3 0.2 2.2e-06 27.5 0.2 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold PROL5-SMR PF15621.4 001293114.1_02222001_2 - 0.0013 19.1 4.6 0.0019 18.6 4.6 1.2 1 0 0 1 1 1 1 Proline-rich submaxillary gland androgen-regulated family Filament PF00038.19 001293119.1_02223001_1 - 5.3e-106 354.6 30.0 6.5e-106 354.3 30.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 001293119.1_02223001_1 - 0.0034 17.3 4.6 0.0034 17.3 4.6 3.8 2 2 1 3 3 3 1 TPR/MLP1/MLP2-like protein Bacillus_HBL PF05791.9 001293119.1_02223001_1 - 0.04 13.5 5.3 0.028 14.0 2.3 2.1 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Baculo_PEP_C PF04513.10 001293119.1_02223001_1 - 0.057 13.3 7.9 1.5 8.7 0.2 3.4 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prefoldin PF02996.15 001293119.1_02223001_1 - 0.058 13.2 9.8 1.4 8.7 0.9 4.0 4 1 0 4 4 4 0 Prefoldin subunit CVNH PF08881.8 001293119.1_02223001_1 - 0.077 13.6 2.2 0.44 11.1 0.3 2.9 1 1 1 2 2 2 0 CVNH domain DUF2730 PF10805.6 001293119.1_02223001_1 - 0.093 12.7 4.9 0.69 9.9 1.1 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) ADIP PF11559.6 001293119.1_02223001_1 - 0.23 11.4 25.8 0.095 12.6 8.8 4.0 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding Reo_sigmaC PF04582.10 001293119.1_02223001_1 - 0.27 10.4 3.8 0.44 9.8 1.5 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Lzipper-MIP1 PF14389.4 001293119.1_02223001_1 - 0.5 10.5 13.7 0.15 12.2 1.9 3.7 4 1 0 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 DUF342 PF03961.11 001293119.1_02223001_1 - 0.53 8.7 10.6 0.81 8.1 8.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Tropomyosin_1 PF12718.5 001293119.1_02223001_1 - 0.7 9.9 19.5 0.069 13.2 6.8 3.4 3 0 0 3 3 3 0 Tropomyosin like Sec2p PF06428.9 001293119.1_02223001_1 - 1.1 9.2 14.6 4.1 7.3 3.3 4.0 2 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p Macoilin PF09726.7 001293119.1_02223001_1 - 2.5 6.4 17.9 15 3.9 17.1 2.0 1 1 0 1 1 1 0 Transmembrane protein Golgin_A5 PF09787.7 001293119.1_02223001_1 - 2.8 7.2 22.2 2.4 7.4 10.8 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 5 Fez1 PF06818.13 001293119.1_02223001_1 - 3.7 7.8 22.3 0.064 13.6 7.2 2.8 1 1 1 2 2 2 0 Fez1 DUF641 PF04859.10 001293119.1_02223001_1 - 4.5 7.5 18.2 2.5 8.3 3.1 3.6 2 2 1 3 3 3 0 Plant protein of unknown function (DUF641) Jnk-SapK_ap_N PF09744.7 001293119.1_02223001_1 - 7.1 6.7 27.3 0.58 10.2 5.9 3.5 2 2 2 4 4 4 0 JNK_SAPK-associated protein-1 TBPIP PF07106.11 001293119.1_02223001_1 - 8 6.1 20.3 0.07 12.8 8.0 3.0 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Filament PF00038.19 001293120.1_02223001_1 - 4.4e-104 348.3 28.3 5e-104 348.1 28.3 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 001293120.1_02223001_1 - 5.7e-06 26.3 3.0 5.7e-06 26.3 3.0 3.4 3 1 0 3 3 3 1 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.7 001293120.1_02223001_1 - 0.00082 19.3 35.6 0.0016 18.4 7.4 4.6 2 2 1 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SPATA1_C PF15743.3 001293120.1_02223001_1 - 0.022 14.7 0.3 0.022 14.7 0.3 3.5 2 1 0 2 2 1 0 Spermatogenesis-associated C-terminus DUF2746 PF10874.6 001293120.1_02223001_1 - 0.11 12.8 3.5 0.62 10.4 0.2 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2746) DUF972 PF06156.11 001293120.1_02223001_1 - 0.17 12.4 24.4 2.1 8.9 0.2 5.6 2 2 4 6 6 6 0 Protein of unknown function (DUF972) RasGAP_C PF03836.13 001293120.1_02223001_1 - 0.34 11.0 10.0 1.3 9.1 0.4 3.3 2 1 1 3 3 3 0 RasGAP C-terminus Laminin_II PF06009.10 001293120.1_02223001_1 - 0.42 10.5 12.7 3.3 7.6 2.2 4.0 2 2 2 4 4 4 0 Laminin Domain II Phage_GP20 PF06810.9 001293120.1_02223001_1 - 2.3 7.9 14.5 0.2 11.3 3.3 3.1 2 1 1 3 3 3 0 Phage minor structural protein GP20 Tropomyosin_1 PF12718.5 001293120.1_02223001_1 - 3.1 7.8 26.8 2.3 8.2 1.8 3.4 3 0 0 3 3 3 0 Tropomyosin like DUF4349 PF14257.4 001293120.1_02223001_1 - 3.2 7.1 8.3 0.28 10.5 3.1 1.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4349) Jnk-SapK_ap_N PF09744.7 001293120.1_02223001_1 - 3.4 7.7 29.3 2 8.5 4.5 3.8 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 FlxA PF14282.4 001293120.1_02223001_1 - 3.5 7.5 22.2 1.7 8.6 6.8 4.2 2 2 1 4 4 4 0 FlxA-like protein DUF4407 PF14362.4 001293120.1_02223001_1 - 5.1 6.2 15.9 0.77 8.9 2.4 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF724 PF05266.12 001293120.1_02223001_1 - 8 6.1 19.8 3.1 7.4 0.7 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF724) Kinetocho_Slk19 PF12709.5 001293120.1_02223001_1 - 9.3 6.6 21.8 2.2 8.7 0.9 4.9 3 3 2 5 5 5 0 Central kinetochore-associated VWD PF00094.23 001302556.1_02229001_1 - 7.8e-119 393.3 20.2 2.6e-36 125.1 1.1 4.3 4 0 0 4 4 4 4 von Willebrand factor type D domain C8 PF08742.9 001302556.1_02229001_1 - 5.8e-55 183.5 44.1 9.7e-20 70.6 1.1 8.2 5 0 0 5 5 5 3 C8 domain TIL PF01826.15 001302556.1_02229001_1 - 7.5e-27 93.2 67.8 1.4e-12 47.5 17.1 29.8 17 3 8 25 25 25 3 Trypsin Inhibitor like cysteine rich domain TILa PF12714.5 001302556.1_02229001_1 - 4e-19 68.2 503.0 2.4e-10 40.1 7.2 50.6 28 16 23 51 51 51 32 TILa domain FOLN PF09289.8 001302556.1_02229001_1 - 0.00035 20.6 11.1 0.00079 19.4 3.1 39.9 44 0 0 44 44 44 14 Follistatin/Osteonectin-like EGF domain Dynein_light PF01221.16 001302556.1_02229001_1 - 0.14 12.4 0.2 0.89 9.8 0.0 2.4 2 0 0 2 2 2 0 Dynein light chain type 1 Orn_Arg_deC_N PF02784.14 001293706.2_02225001_1 - 2.9e-65 220.0 0.0 3.9e-65 219.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001293706.2_02225001_1 - 9.3e-21 73.9 0.0 1.7e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 001293706.2_02225001_1 - 0.012 14.9 0.0 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Amelotin PF15757.3 001328228.1_02223001_2 - 4.8e-24 84.9 20.8 3.1e-22 79.0 15.5 2.4 2 1 0 2 2 2 2 Amelotin MHC_I_3 PF16497.3 001328223.1_02223001_1 - 3.9e-30 104.7 0.1 5.7e-30 104.1 0.1 1.2 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001328223.1_02223001_1 - 1.4e-14 54.2 0.0 2.5e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001328223.1_02223001_1 - 1.6e-11 43.9 0.0 2.4e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_3 PF13927.4 001328223.1_02223001_1 - 0.00026 21.4 0.0 0.00047 20.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001328223.1_02223001_1 - 0.018 15.0 0.0 0.039 14.0 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain FixS PF03597.13 001328223.1_02223001_1 - 0.028 14.0 0.0 0.028 14.0 0.0 2.0 2 0 0 2 2 2 0 Cytochrome oxidase maturation protein cbb3-type DUF1310 PF07006.9 001328223.1_02223001_1 - 0.042 13.7 0.3 0.077 12.8 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1310) Amelin PF05111.10 001328227.1_02224001_1 - 2.6e-61 207.9 25.3 3.5e-61 207.5 25.3 1.1 1 0 0 1 1 1 1 Ameloblastin precursor (Amelin) BNR_2 PF13088.4 001328222.1_02223001_1 - 3.2e-37 128.2 0.0 4.7e-37 127.7 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.4 001328222.1_02223001_1 - 1.4e-09 37.5 0.0 1.9e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.18 001328222.1_02223001_1 - 2.7e-05 23.4 3.0 0.15 12.0 0.4 3.1 2 0 0 2 2 2 2 BNR/Asp-box repeat Glyco_transf_36 PF06165.9 001328222.1_02223001_1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 36 Interfer-bind PF09294.8 001328225.1_02223001_3 - 7.9e-22 77.4 0.9 1.7e-21 76.3 0.0 2.1 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.15 001328225.1_02223001_3 - 3.8e-16 58.7 3.4 5.3e-15 55.0 0.5 2.5 2 0 0 2 2 2 2 Tissue factor V-set_CD47 PF08204.9 001328225.1_02223001_3 - 0.033 14.0 0.6 0.069 13.0 0.6 1.5 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain DUF1619 PF07773.9 001310087.1_23524001_3 - 1.7e-55 189.1 0.6 2.6e-50 172.1 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1619) 7tm_1 PF00001.19 001037824.1_23523001_1 - 1.3e-50 172.0 20.6 1.7e-50 171.7 20.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001037824.1_23523001_1 - 1.2e-11 44.4 18.5 1.6e-11 43.9 18.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001037824.1_23523001_1 - 3.8e-07 30.0 15.3 5.9e-07 29.4 15.3 1.3 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001037824.1_23523001_1 - 0.00016 21.0 11.9 0.00016 21.0 11.9 2.2 1 1 2 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.7 001037824.1_23523001_1 - 0.0036 16.5 16.7 0.31 10.1 16.7 2.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw Med3 PF11593.6 001037824.1_23523001_2 - 3.7 6.5 5.3 5 6.1 5.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal zf-H2C2_2 PF13465.4 001114702.1_16125001_1 - 7.9e-31 105.0 23.6 6e-08 32.7 0.2 6.0 5 0 0 5 5 5 5 Zinc-finger double domain zf-C2H2 PF00096.24 001114702.1_16125001_1 - 2.1e-22 78.1 52.1 9.2e-07 28.9 1.3 7.3 8 0 0 8 8 7 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001114702.1_16125001_1 - 2.5e-09 37.0 17.7 0.001 19.6 0.3 7.5 8 0 0 8 8 6 4 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001114702.1_16125001_1 - 2e-07 30.7 23.4 0.013 15.3 0.2 5.7 5 1 0 5 5 5 3 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001114702.1_16125001_1 - 0.0015 18.5 16.2 0.032 14.2 3.0 4.6 4 0 0 4 4 4 1 Zinc ribbon domain zf-LYAR PF08790.9 001114702.1_16125001_1 - 0.0015 18.3 11.3 4.3 7.2 0.1 5.0 4 0 0 4 4 4 3 LYAR-type C2HC zinc finger zf-H2C2_5 PF13909.4 001114702.1_16125001_1 - 0.002 17.7 33.8 0.0024 17.4 1.1 6.0 5 3 0 5 5 5 3 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 001114702.1_16125001_1 - 0.0066 16.6 21.5 6.1 7.1 0.6 5.9 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding CpXC PF14353.4 001114702.1_16125001_1 - 0.026 14.4 13.0 7.9 6.4 0.2 4.5 1 1 3 4 4 4 0 CpXC protein zf-RING_7 PF02591.13 001114702.1_16125001_1 - 0.39 10.8 6.6 5.6 7.1 0.1 4.3 4 0 0 4 4 4 0 C4-type zinc ribbon domain DUF3268 PF11672.6 001114702.1_16125001_1 - 0.93 9.7 10.3 5.4 7.2 1.7 2.7 1 1 0 2 2 2 0 zinc-finger-containing domain MTCP1 PF08991.8 001303002.1_16121001_2 - 2.9e-17 62.5 12.3 4.7e-17 61.8 12.3 1.3 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type LysM PF01476.18 001076750.1_16125001_1 - 3.4e-07 30.1 0.0 6e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 LysM domain Troponin PF00992.18 001201542.1_16124001_3 - 4.1e-32 111.2 43.5 6.8e-30 104.0 37.4 2.3 1 1 1 2 2 2 2 Troponin Aldo_ket_red PF00248.19 001002369.1_16123001_2 - 1.6e-49 168.5 0.0 2.2e-49 168.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family FoP_duplication PF13865.4 001077306.1_16124001_1 - 7e-16 58.4 0.0 7e-16 58.4 0.0 2.7 3 0 0 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 Auxin_repressed PF05564.10 001077306.1_16124001_1 - 0.031 14.8 0.4 0.08 13.5 0.2 1.7 1 1 1 2 2 2 0 Dormancy/auxin associated protein COMM_domain PF07258.12 001002421.1_16122001_2 - 9.7e-21 73.5 1.9 1.3e-20 73.1 0.1 2.0 2 0 0 2 2 2 1 COMM domain XPC-binding PF09280.9 001002421.1_16122001_2 - 0.24 11.1 4.1 0.41 10.3 0.2 2.5 2 0 0 2 2 2 0 XPC-binding domain Motile_Sperm PF00635.24 001002546.1_16123001_2 - 7.8e-33 112.4 0.2 1.2e-32 111.8 0.2 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ASH PF15780.3 001002546.1_16123001_2 - 0.0067 16.5 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF972 PF06156.11 001002546.1_16123001_2 - 0.11 12.9 0.2 0.22 12.0 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DivIC PF04977.13 001002546.1_16123001_2 - 0.12 12.0 0.1 0.23 11.1 0.1 1.4 1 0 0 1 1 1 0 Septum formation initiator FYRN PF05964.12 001114446.1_16124001_1 - 2.9e-22 78.1 0.0 5.6e-22 77.2 0.0 1.5 1 0 0 1 1 1 1 F/Y-rich N-terminus FYRC PF05965.12 001114446.1_16124001_1 - 4.9e-21 74.5 0.0 1e-20 73.5 0.0 1.6 1 0 0 1 1 1 1 F/Y rich C-terminus HARE-HTH PF05066.11 001114446.1_16124001_1 - 3.7e-16 59.1 0.1 5.5e-15 55.4 0.0 2.5 2 0 0 2 2 2 1 HB1, ASXL, restriction endonuclease HTH domain RRM_1 PF00076.20 001077760.1_16127001_2 - 8.1e-06 25.4 0.0 0.0021 17.7 0.0 3.9 3 1 1 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001077760.1_16127001_2 - 0.00013 21.4 0.0 0.0011 18.4 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-met PF12874.5 001077760.1_16127001_2 - 0.026 14.8 11.6 0.45 10.8 4.2 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001077760.1_16127001_2 - 0.96 9.7 18.3 0.033 14.4 2.0 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding AIG1 PF04548.14 001114587.1_16123001_1 - 4e-54 183.0 0.9 4.9e-54 182.7 0.2 1.4 2 0 0 2 2 2 1 AIG1 family MMR_HSR1 PF01926.21 001114587.1_16123001_1 - 4e-08 33.2 0.0 8e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.21 001114587.1_16123001_1 - 0.00014 21.8 0.3 0.19 11.6 0.0 2.5 1 1 1 2 2 2 2 Dynamin family DUF258 PF03193.14 001114587.1_16123001_1 - 0.00062 19.6 0.3 0.0019 18.0 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function, DUF258 ABC_tran PF00005.25 001114587.1_16123001_1 - 0.034 14.5 0.0 0.05 14.0 0.0 1.4 1 0 0 1 1 1 0 ABC transporter THAP PF05485.10 001079658.1_16123001_2 - 3.3e-11 43.9 0.0 6.2e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 THAP domain C1-set PF07654.13 131706.1_16122001_1 - 8.1e-20 71.0 0.0 1.3e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_II_beta PF00969.17 131706.1_16122001_1 - 1.6e-07 31.2 0.3 4.5e-07 29.8 0.4 1.7 2 0 0 2 2 2 1 Class II histocompatibility antigen, beta domain C2-set_2 PF08205.10 131706.1_16122001_1 - 3e-05 23.9 0.0 4.4e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 131706.1_16122001_1 - 0.018 15.5 0.1 0.058 13.9 0.0 1.8 2 1 0 2 2 2 0 Immunoglobulin domain Pentapeptide PF00805.20 001002738.1_16124001_3 - 6.5e-39 131.0 25.3 3.3e-12 45.7 3.1 4.5 2 2 2 4 4 4 4 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.4 001002738.1_16124001_3 - 2.6e-21 75.4 0.7 2.6e-09 36.9 0.0 3.4 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) BTB_2 PF02214.20 001002738.1_16124001_3 - 5.2e-21 74.7 0.0 8.6e-21 74.0 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain KHA PF11834.6 001002738.1_16124001_3 - 8.6e-18 64.1 0.0 1.7e-17 63.2 0.0 1.5 1 0 0 1 1 1 1 KHA, dimerisation domain of potassium ion channel Pentapeptide_3 PF13576.4 001002738.1_16124001_3 - 6.2e-16 58.1 0.0 3.9e-05 23.6 0.0 4.6 3 1 1 4 4 4 4 Pentapeptide repeats (9 copies) BTB PF00651.29 001002738.1_16124001_3 - 5.2e-06 26.5 0.0 9.8e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.3 001002738.1_16124001_3 - 8.5e-06 25.7 0.0 1.6e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Hid1 PF12722.5 001002739.1_16126001_3 - 1.4e-277 922.9 1.4 1.6e-277 922.8 1.4 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.7 001002739.1_16126001_3 - 1.9e-239 796.2 4.0 2.2e-239 796.0 4.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein UQ_con PF00179.24 001002747.1_16125001_2 - 6.5e-52 174.8 0.0 9.5e-52 174.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.20 001002747.1_16125001_2 - 0.01 16.0 0.1 0.019 15.1 0.1 1.3 1 0 0 1 1 1 0 RWD domain RPE65 PF03055.13 131799.1_16125001_2 - 9.8e-117 390.5 0.0 1.1e-116 390.3 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein MFS_1 PF07690.14 001256640.1_16123001_1 - 1.3e-38 132.7 40.0 9.8e-32 110.1 30.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 001256640.1_16123001_1 - 4.5 5.9 25.2 0.057 12.1 8.6 3.2 3 1 1 4 4 4 0 Sugar (and other) transporter Ribosomal_L15e PF00827.15 001003447.1_16122001_3 - 6.3e-96 319.5 4.6 7.8e-96 319.2 4.6 1.1 1 0 0 1 1 1 1 Ribosomal L15 V-set PF07686.15 001258233.1_16123001_3 - 7.4e-08 32.4 1.2 7.4e-08 32.4 1.2 1.8 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.23 001258233.1_16123001_3 - 1.2e-06 28.5 3.3 2.6e-06 27.4 2.2 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.4 001258233.1_16123001_3 - 4e-06 27.2 1.4 1.1e-05 25.8 1.4 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001258233.1_16123001_3 - 1.5e-05 24.9 0.1 3.2e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Adipogenin PF15202.4 001258233.1_16123001_3 - 0.00092 19.1 8.2 0.031 14.2 0.2 3.6 3 0 0 3 3 3 1 Adipogenin Ig_2 PF13895.4 001258233.1_16123001_3 - 0.0046 17.1 1.9 0.0097 16.1 1.9 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Yip1 PF04893.15 001003500.1_16124001_1 - 2.4e-19 69.6 12.1 3.3e-19 69.1 12.1 1.1 1 0 0 1 1 1 1 Yip1 domain Myb_DNA-binding PF00249.29 001080041.1_16126001_3 - 3.9e-17 62.0 0.0 1.2e-09 38.1 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain ELM2 PF01448.22 001080041.1_16126001_3 - 1.3e-11 44.9 0.1 1.3e-11 44.9 0.1 2.2 2 0 0 2 2 2 1 ELM2 domain Myb_DNA-bind_7 PF15963.3 001080041.1_16126001_3 - 5.3e-06 26.1 6.3 0.00088 19.0 0.4 2.5 2 0 0 2 2 2 2 Myb DNA-binding like Myb_DNA-bind_6 PF13921.4 001080041.1_16126001_3 - 9.7e-05 22.4 3.7 0.086 13.0 0.1 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain FLO_LFY PF01698.14 001080041.1_16126001_3 - 0.33 10.0 4.0 0.75 8.8 4.0 1.5 1 0 0 1 1 1 0 Floricaula / Leafy protein UBN_AB PF14075.4 001080169.1_16129001_3 - 5.2e-71 238.6 1.8 8.1e-71 238.0 1.8 1.3 1 0 0 1 1 1 1 Ubinuclein conserved middle domain HUN PF08729.8 001080169.1_16129001_3 - 8.3e-20 70.4 0.5 4e-19 68.2 0.1 2.1 2 0 0 2 2 2 1 HPC2 and ubinuclein domain L51_S25_CI-B8 PF05047.14 001002428.2_16123001_2 - 2.9e-10 39.8 0.0 4.5e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain MgtE_N PF03448.15 001002428.2_16123001_2 - 0.07 13.6 0.0 0.11 13.0 0.0 1.1 1 0 0 1 1 1 0 MgtE intracellular N domain VWA_2 PF13519.4 001002112.2_16123001_3 - 6.1e-25 87.8 0.1 3.8e-24 85.3 0.0 2.3 2 1 0 2 2 2 1 von Willebrand factor type A domain Ssl1 PF04056.12 001002112.2_16123001_3 - 1.3e-07 31.5 0.1 2.1e-07 30.8 0.1 1.3 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.18 001002112.2_16123001_3 - 1.7e-07 30.6 4.5 0.0012 18.5 0.2 3.1 2 0 0 2 2 2 2 Ubiquitin interaction motif VWA PF00092.26 001002112.2_16123001_3 - 1.4e-06 28.6 0.0 4.2e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 von Willebrand factor type A domain PID PF00640.21 001002112.2_16123001_3 - 0.07 13.0 0.0 0.22 11.4 0.0 1.9 1 1 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Pkinase PF00069.23 001080669.1_16125001_1 - 5.9e-42 143.7 5.9 1.3e-22 80.3 0.1 2.5 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.15 001080669.1_16125001_1 - 1.6e-14 53.7 0.0 6.7e-11 41.8 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pox_Ag35 PF03286.12 001080669.1_16125001_1 - 0.62 9.7 13.1 0.71 9.5 4.6 2.4 2 0 0 2 2 2 0 Pox virus Ag35 surface protein 2OG-FeII_Oxy_3 PF13640.4 001080691.1_16125001_2 - 1.4e-09 38.6 0.1 3.2e-09 37.4 0.1 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EF-hand_5 PF13202.4 001080691.1_16125001_2 - 0.00012 21.3 0.0 0.036 13.5 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 001080691.1_16125001_2 - 0.00048 20.4 0.0 0.0011 19.3 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 001080691.1_16125001_2 - 0.0042 16.8 0.0 0.21 11.5 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.30 001080691.1_16125001_2 - 0.0046 16.3 0.0 0.13 11.7 0.0 2.5 2 0 0 2 2 2 1 EF hand 7tm_1 PF00001.19 001080691.1_16125001_2 - 1.2 8.2 7.4 3.1 6.8 5.5 2.2 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) RNA_pol_Rpb5_N PF03871.12 001003564.2_16122001_2 - 1.4e-35 121.5 0.1 2.5e-35 120.7 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain RNA_pol_Rpb5_C PF01191.17 001003564.2_16122001_2 - 1.4e-35 120.8 0.3 2.7e-35 119.8 0.3 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain FumaraseC_C PF10415.7 001003564.2_16122001_2 - 0.066 13.5 0.6 2 8.8 0.0 2.5 2 0 0 2 2 2 0 Fumarase C C-terminus Connexin PF00029.17 131800.2_16123001_2 - 0.067 12.8 2.7 0.11 12.1 2.7 1.4 1 0 0 1 1 1 0 Connexin DUF788 PF05620.9 131800.2_16123001_2 - 0.12 12.2 4.5 0.23 11.2 4.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF788) Folate_carrier PF01770.16 131800.2_16123001_2 - 0.95 8.0 2.7 1.3 7.5 2.7 1.1 1 0 0 1 1 1 0 Reduced folate carrier EIF_2_alpha PF07541.10 131800.2_16123001_3 - 1.9e-36 124.5 0.0 4.7e-36 123.3 0.0 1.7 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.21 131800.2_16123001_3 - 4.9e-15 55.5 0.7 4.9e-15 55.5 0.7 2.6 2 1 0 2 2 2 1 S1 RNA binding domain V-set PF07686.15 198355.1_16122001_2 - 7.8e-12 45.2 0.0 1.5e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 198355.1_16122001_2 - 3e-05 24.4 0.0 6.7e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 198355.1_16122001_2 - 0.00018 21.5 0.0 0.00035 20.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 198355.1_16122001_2 - 0.012 15.5 0.0 0.032 14.2 0.0 1.7 1 1 0 1 1 1 0 Immunoglobulin I-set domain F-box-like PF12937.5 131521.2_16124001_3 - 2.5e-11 43.1 0.7 7.5e-11 41.6 0.7 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 131521.2_16124001_3 - 1.3e-10 40.7 0.7 5.2e-10 38.8 0.7 2.1 1 0 0 1 1 1 1 F-box domain WD40 PF00400.30 131521.2_16124001_3 - 1.4e-09 38.3 21.4 0.0019 18.9 0.2 7.1 7 1 0 7 7 7 4 WD domain, G-beta repeat F-box_4 PF15966.3 131521.2_16124001_3 - 0.00092 18.9 0.3 0.017 14.9 0.0 2.4 2 0 0 2 2 2 1 F-box DUF778 PF05608.10 001013316.2_16127001_3 - 6.9e-40 137.3 9.4 1e-23 84.5 0.1 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF778) PfkB PF00294.22 198802.1_16124001_3 - 5.7e-74 249.0 0.1 6.8e-74 248.8 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.10 198802.1_16124001_3 - 0.069 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase VIT PF08487.8 001004604.1_16127001_3 - 8.8e-30 103.1 0.0 1.5e-29 102.4 0.0 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.4 001004604.1_16127001_3 - 5.9e-26 91.1 0.0 2.8e-25 88.9 0.0 2.2 3 0 0 3 3 3 1 von Willebrand factor type A domain VIT_2 PF13757.4 001004604.1_16127001_3 - 3.1e-14 52.5 0.0 7e-14 51.3 0.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_2 PF13519.4 001004604.1_16127001_3 - 1e-10 42.1 0.0 1.9e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.26 001004604.1_16127001_3 - 4.2e-08 33.5 0.0 8.4e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.12 001004604.1_16127001_3 - 0.026 13.8 0.0 9.1 5.5 0.0 2.7 3 0 0 3 3 3 0 VWA domain containing CoxE-like protein Myb_DNA-bind_7 PF15963.3 001083820.1_16124001_1 - 6.6e-25 86.7 0.5 6.6e-25 86.7 0.5 2.6 4 0 0 4 4 4 1 Myb DNA-binding like Myb_DNA-binding PF00249.29 001083820.1_16124001_1 - 0.0021 18.1 0.0 0.0078 16.2 0.0 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain P-mevalo_kinase PF04275.12 001083820.1_16124001_1 - 0.015 15.1 2.0 0.032 14.0 2.0 1.6 1 0 0 1 1 1 0 Phosphomevalonate kinase zf-C3Hc3H PF13891.4 001005990.1_16123001_1 - 3.2e-31 107.4 18.2 1.3e-16 60.6 5.5 2.4 2 0 0 2 2 2 2 Potential DNA-binding domain DUF3135 PF11333.6 001005990.1_16123001_1 - 0.042 14.0 0.1 0.14 12.3 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3135) WRC PF08879.8 001005990.1_16123001_1 - 1.9 8.2 8.5 15 5.4 0.2 3.6 3 0 0 3 3 3 0 WRC Methyltr_RsmB-F PF01189.15 199711.1_16126001_2 - 8.7e-37 126.6 0.0 1.4e-35 122.6 0.0 2.3 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.17 199711.1_16126001_2 - 0.073 13.0 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase MVL PF12151.6 001006066.1_16122001_1 - 2.1 8.1 0.0 2.1 8.1 0.0 3.7 4 0 0 4 4 4 0 Mannan-binding protein CARD PF00619.19 001006066.1_16122001_2 - 4.2e-14 52.2 1.7 7.5e-14 51.4 1.7 1.4 1 0 0 1 1 1 1 Caspase recruitment domain Death PF00531.20 001006066.1_16122001_2 - 7.4e-10 38.7 0.7 3.5e-09 36.6 0.0 2.1 2 0 0 2 2 2 1 Death domain 4HBT_3 PF13622.4 001006072.1_16124001_1 - 1.2e-61 208.9 0.5 1.5e-61 208.7 0.5 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.13 001006072.1_16124001_1 - 3.8e-33 114.0 0.0 3.1e-25 88.4 0.0 3.1 2 1 0 2 2 2 2 Acyl-CoA thioesterase Succ_CoA_lig PF13607.4 001006072.1_16124001_1 - 0.026 14.2 0.0 6.2 6.5 0.0 2.2 2 0 0 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain zf-C2H2 PF00096.24 199815.1_16128001_3 - 3.2e-19 68.1 35.2 0.0018 18.5 0.1 7.2 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 199815.1_16128001_3 - 1.8e-17 62.4 42.1 0.012 16.3 1.4 7.8 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 199815.1_16128001_3 - 3.1e-09 36.8 4.3 0.099 12.9 0.0 6.2 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 199815.1_16128001_3 - 4.5e-07 29.9 4.7 0.026 14.8 0.0 4.9 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-Di19 PF05605.10 199815.1_16128001_3 - 2.9e-06 27.3 22.8 0.43 10.8 0.4 6.5 7 0 0 7 7 7 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 199815.1_16128001_3 - 4.4e-05 23.2 22.9 0.041 13.7 0.2 6.1 6 0 0 6 6 6 3 C2H2-type zinc finger zf-LYAR PF08790.9 199815.1_16128001_3 - 0.011 15.5 6.2 1.3 8.8 0.1 4.3 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger CpXC PF14353.4 199815.1_16128001_3 - 0.27 11.1 13.9 2 8.3 0.6 5.3 6 0 0 6 6 6 0 CpXC protein WCCH PF03716.12 199815.1_16128001_3 - 2 8.0 11.1 6.2 6.5 11.1 1.9 1 0 0 1 1 1 0 WCCH motif Ig_3 PF13927.4 001115052.2_16123001_2 - 8.7e-18 64.6 0.4 8.3e-08 32.6 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 001115052.2_16123001_2 - 3.8e-15 55.7 0.3 2.5e-06 27.4 0.0 4.0 2 1 1 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001115052.2_16123001_2 - 2.4e-13 50.1 0.0 9.6e-11 41.7 0.0 2.8 3 0 0 3 3 3 1 Immunoglobulin V-set domain Ig_2 PF13895.4 001115052.2_16123001_2 - 1.9e-10 40.8 0.5 4.5e-06 26.8 0.1 3.9 4 0 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.10 001115052.2_16123001_2 - 2.4e-09 37.0 0.3 1.5e-08 34.5 0.1 2.4 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain I-set PF07679.14 001115052.2_16123001_2 - 9.3e-09 35.1 0.1 0.007 16.3 0.0 4.2 3 2 0 3 3 3 2 Immunoglobulin I-set domain C1-set PF07654.13 001115052.2_16123001_2 - 1.4e-05 25.3 0.1 0.00038 20.8 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_5 PF16681.3 001115052.2_16123001_2 - 0.0091 16.3 0.1 0.092 13.0 0.0 2.5 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 001115052.2_16123001_2 - 0.02 15.1 0.4 0.6 10.4 0.0 3.1 4 0 0 4 4 4 0 T-cell surface glycoprotein CD3 delta chain Spy1 PF11357.6 001006091.1_16123001_2 - 2.5e-59 199.1 6.0 3.3e-59 198.8 6.0 1.1 1 0 0 1 1 1 1 Cell cycle regulatory protein CTD_bind PF04818.11 001007307.1_16129001_2 - 1.7e-06 28.6 0.0 4.9e-06 27.1 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CFIA_Pcf11 PF11526.6 001007307.1_16129001_2 - 0.0025 18.1 2.1 0.0025 18.1 2.1 3.3 3 0 0 3 3 3 1 Subunit of cleavage factor IA Pcf11 Ribosomal_60s PF00428.17 001007307.1_16129001_2 - 0.13 12.7 0.1 0.13 12.7 0.1 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein zf-C2H2_3 PF13878.4 001007307.1_16129001_2 - 0.32 10.7 1.5 3.4 7.4 0.1 2.7 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO Pex26 PF07163.10 199920.1_16123001_2 - 1.3e-124 415.3 1.3 1.5e-124 415.1 1.3 1.0 1 0 0 1 1 1 1 Pex26 protein DUF2464 PF10240.7 199920.1_16123001_2 - 0.015 14.7 0.0 0.022 14.2 0.0 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 MULE PF10551.7 001128721.1_16122001_2 - 6.4e-06 26.5 0.2 1.3e-05 25.5 0.2 1.5 1 0 0 1 1 1 1 MULE transposase domain Ank_2 PF12796.5 001017563.2_16123001_2 - 6.2e-62 206.1 16.0 1.4e-17 63.9 0.0 5.7 2 1 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001017563.2_16123001_2 - 5.2e-61 202.2 18.0 1.8e-13 50.5 0.3 6.5 2 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.4 001017563.2_16123001_2 - 2.8e-47 153.0 11.8 1.7e-05 24.7 0.0 9.9 10 0 0 10 10 10 9 Ankyrin repeat Ank PF00023.28 001017563.2_16123001_2 - 2.3e-43 144.7 19.5 1.8e-06 28.0 0.0 10.8 11 1 0 11 11 11 8 Ankyrin repeat Ank_5 PF13857.4 001017563.2_16123001_2 - 3.2e-42 141.7 11.0 2.1e-09 37.4 0.0 7.9 3 3 5 8 8 8 7 Ankyrin repeats (many copies) PrpR_N PF06506.9 001017563.2_16123001_2 - 0.0023 17.4 0.0 0.0042 16.6 0.0 1.4 1 0 0 1 1 1 1 Propionate catabolism activator DUF3447 PF11929.6 001017563.2_16123001_2 - 0.03 14.1 0.5 5.1 7.0 0.1 4.0 3 1 2 5 5 5 0 Domain of unknown function (DUF3447) MFS_1 PF07690.14 001007439.1_16125001_2 - 1.7e-43 148.8 41.2 5.6e-32 110.9 21.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily COX15-CtaA PF02628.13 201206.2_16124001_2 - 8.7e-114 379.8 6.2 1.1e-113 379.4 6.2 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Myb_DNA-binding PF00249.29 001008605.1_16124001_2 - 0.00015 21.7 0.0 0.00026 21.0 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.3 001008605.1_16124001_2 - 0.00048 19.8 0.0 0.00089 19.0 0.0 1.4 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.4 001008605.1_16124001_2 - 0.004 17.2 0.0 0.0072 16.4 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain DHO_dh PF01180.19 001008608.1_16124001_3 - 2.3e-112 374.9 0.0 8.6e-112 373.0 0.0 1.7 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase FMN_dh PF01070.16 001008608.1_16124001_3 - 0.0018 17.3 0.5 0.013 14.4 0.5 2.1 2 1 0 2 2 2 1 FMN-dependent dehydrogenase Dus PF01207.15 001008608.1_16124001_3 - 0.023 13.7 0.0 0.036 13.0 0.0 1.2 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) Epimerase PF01370.19 001008620.1_16124001_2 - 1.9e-52 178.0 0.0 3.3e-52 177.2 0.0 1.4 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 001008620.1_16124001_2 - 1.7e-09 37.3 0.0 1.7e-09 37.3 0.0 1.9 2 1 1 3 3 3 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.15 001008620.1_16124001_2 - 1.4e-06 27.5 0.0 3.1e-06 26.4 0.0 1.5 2 0 0 2 2 2 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.13 001008620.1_16124001_2 - 0.00037 19.6 0.8 0.0032 16.5 0.0 2.3 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein DUF788 PF05620.9 001008620.1_16124001_3 - 0.1 12.4 4.6 0.22 11.3 4.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF788) DUF4604 PF15377.4 001008620.1_16124001_3 - 2.6 8.3 18.7 3.8 7.8 18.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) GATase_6 PF13522.4 001082877.2_16125001_1 - 2.1e-13 50.5 0.0 4.4e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.4 001082877.2_16125001_1 - 6.7e-11 42.1 0.0 1.1e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.25 001082877.2_16125001_1 - 1.6e-07 30.9 0.1 2.8e-07 30.1 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.4 001082877.2_16125001_1 - 9.4e-05 21.3 0.0 0.00015 20.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II UPRTase PF14681.4 001082877.2_16125001_1 - 0.14 11.4 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase PPR PF01535.18 001082877.2_16125001_1 - 0.16 12.2 0.1 0.56 10.5 0.0 2.0 2 0 0 2 2 2 0 PPR repeat PRTase_2 PF15609.4 001082877.2_16125001_1 - 0.18 11.1 0.0 0.3 10.4 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase Zn_Tnp_IS1595 PF12760.5 001099227.1_16123001_1 - 0.083 12.8 0.5 0.083 12.8 0.5 1.8 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-C2H2 PF00096.24 001099227.1_16123001_3 - 3.1e-31 105.9 83.1 3.4e-07 30.2 1.9 11.5 11 1 0 11 11 11 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001099227.1_16123001_3 - 2.6e-27 93.0 76.8 6.8e-05 23.2 1.0 10.9 11 0 0 11 11 10 9 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001099227.1_16123001_3 - 9.1e-21 73.2 84.0 2.8e-06 27.4 0.6 10.8 11 1 1 12 12 11 6 Zinc-finger double domain zf-met PF12874.5 001099227.1_16123001_3 - 1.9e-17 62.9 55.4 0.0016 18.6 2.4 9.4 9 0 0 9 9 9 6 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001099227.1_16123001_3 - 1.5e-16 60.0 53.5 0.0016 18.5 0.5 9.0 9 0 0 9 9 8 8 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001099227.1_16123001_3 - 4.7e-08 32.7 56.9 9.4e-05 22.1 3.4 9.0 9 0 0 9 9 8 5 C2H2-type zinc finger zf-H2C2_5 PF13909.4 001099227.1_16123001_3 - 0.023 14.3 1.2 0.023 14.3 1.2 9.8 12 2 0 12 12 9 0 C2H2-type zinc-finger domain ADK_lid PF05191.12 001099227.1_16123001_3 - 0.097 12.6 22.0 0.21 11.5 0.6 5.3 6 0 0 6 6 4 0 Adenylate kinase, active site lid zf-LYAR PF08790.9 001099227.1_16123001_3 - 0.32 10.8 40.0 1 9.2 0.1 8.1 8 0 0 8 8 8 0 LYAR-type C2HC zinc finger zf-C2H2_2 PF12756.5 001099227.1_16123001_3 - 0.37 11.0 58.6 7.3 6.9 3.4 9.0 2 1 8 10 10 10 0 C2H2 type zinc-finger (2 copies) HypA PF01155.17 001099227.1_16123001_3 - 0.78 9.6 43.8 0.38 10.6 2.6 5.6 1 1 5 6 6 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.8 001099227.1_16123001_3 - 1.6 8.8 38.4 1.2 9.2 1.8 7.0 3 2 3 7 7 7 0 Zinc ribbon domain zf-C2H2_11 PF16622.3 001099227.1_16123001_3 - 1.8 8.3 58.5 1.2 8.9 2.6 9.2 9 0 0 9 9 9 0 zinc-finger C2H2-type DUF3762 PF12591.6 001099227.1_16123001_3 - 4 7.6 8.0 1.8 8.7 2.9 2.7 2 2 0 2 2 2 0 Protein of unknown function (DUF3762) zinc_ribbon_15 PF17032.3 001099227.1_16123001_3 - 5.7 7.6 44.0 0.52 11.0 7.2 5.1 1 1 7 8 8 8 0 zinc-ribbon family Trm112p PF03966.14 001099227.1_16123001_3 - 6 7.4 15.2 13 6.3 0.2 5.1 4 2 0 4 4 4 0 Trm112p-like protein Glyco_transf_29 PF00777.16 001099416.1_16125001_1 - 1.6e-75 253.9 0.0 1.9e-75 253.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Atrophin-1 PF03154.13 001099416.1_16125001_1 - 2.7 6.1 11.3 3.5 5.6 11.3 1.0 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.4 001099416.1_16125001_1 - 4.6 7.1 11.6 9.1 6.2 11.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 001099416.1_16125001_2 - 0.29 9.2 2.0 0.39 8.8 2.0 1.0 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.4 001099416.1_16125001_2 - 0.35 10.7 5.0 0.57 10.0 5.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Adaptin_N PF01602.18 200338.1_16125001_2 - 5.5e-91 305.6 0.2 7.4e-91 305.1 0.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.5 200338.1_16125001_2 - 3e-34 118.2 0.3 1.9e-33 115.6 0.0 2.5 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.8 200338.1_16125001_2 - 1.2e-18 67.1 0.1 3.6e-18 65.6 0.1 1.9 2 0 0 2 2 2 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.4 200338.1_16125001_2 - 5.2e-09 36.2 0.9 0.017 15.4 0.1 5.2 3 2 2 5 5 5 3 HEAT repeats HEAT PF02985.20 200338.1_16125001_2 - 1.6e-07 30.8 3.8 0.31 11.3 0.1 5.7 5 0 0 5 5 5 3 HEAT repeat zf-H2C2_2 PF13465.4 001013306.1_16124001_2 - 4.6e-54 178.4 58.3 1.1e-08 35.0 0.4 9.7 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.24 001013306.1_16124001_2 - 4.8e-44 146.3 71.8 2.3e-06 27.6 1.6 9.6 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001013306.1_16124001_2 - 1.5e-29 99.9 64.7 0.00036 21.0 0.7 9.8 9 0 0 9 9 9 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001013306.1_16124001_2 - 2.6e-13 49.4 56.5 0.0098 15.7 1.7 9.2 9 1 0 9 9 9 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001013306.1_16124001_2 - 2.4e-12 46.7 36.3 0.0056 16.8 0.1 8.1 8 0 0 8 8 8 6 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001013306.1_16124001_2 - 8.3e-06 25.9 56.0 0.0091 16.2 1.1 8.6 8 0 0 8 8 8 4 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 001013306.1_16124001_2 - 9.4e-06 25.5 31.6 0.032 14.2 3.4 6.1 4 1 2 6 6 6 4 Zinc ribbon domain zf-C2H2_11 PF16622.3 001013306.1_16124001_2 - 0.0002 20.9 44.8 0.066 12.8 0.8 7.5 8 0 0 8 8 8 4 zinc-finger C2H2-type C1_1 PF00130.20 001013306.1_16124001_2 - 0.0013 18.5 37.5 0.18 11.5 5.1 6.6 2 2 3 6 6 6 3 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-H2C2_5 PF13909.4 001013306.1_16124001_2 - 0.0014 18.2 0.8 0.0014 18.2 0.8 10.4 9 6 0 9 9 9 3 C2H2-type zinc-finger domain DUF3268 PF11672.6 001013306.1_16124001_2 - 0.0018 18.5 22.4 0.11 12.6 1.7 4.3 4 0 0 4 4 4 3 zinc-finger-containing domain DZR PF12773.5 001013306.1_16124001_2 - 0.0079 16.1 39.8 1.6e+04 -16.0 39.8 5.1 1 1 0 1 1 0 0 Double zinc ribbon HypA PF01155.17 001013306.1_16124001_2 - 0.01 15.7 27.7 1 9.3 2.5 5.2 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.3 001013306.1_16124001_2 - 0.022 15.4 37.1 0.74 10.5 0.4 5.7 2 1 2 5 5 5 0 zinc-ribbon family zf-LYAR PF08790.9 001013306.1_16124001_2 - 0.038 13.8 45.8 1.3 8.8 0.3 8.2 9 0 0 9 9 9 0 LYAR-type C2HC zinc finger CpXC PF14353.4 001013306.1_16124001_2 - 1.2 9.0 34.3 7.1 6.6 0.9 7.9 1 1 6 7 7 7 0 CpXC protein zf-RING_7 PF02591.13 001013306.1_16124001_2 - 1.3 9.1 23.9 1.1 9.4 0.1 6.5 8 0 0 8 8 7 0 C4-type zinc ribbon domain DSPc PF00782.18 001105111.1_16124001_3 - 9.9e-57 190.3 0.0 7.2e-29 100.2 0.0 2.4 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 001105111.1_16124001_3 - 1.4e-09 37.8 0.0 0.0012 18.4 0.0 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase PTPlike_phytase PF14566.4 001105111.1_16124001_3 - 4.9e-05 23.4 0.1 0.66 10.0 0.1 3.0 2 1 0 2 2 2 2 Inositol hexakisphosphate Myotub-related PF06602.12 001105111.1_16124001_3 - 0.00011 21.2 0.0 0.087 11.6 0.0 2.2 2 0 0 2 2 2 2 Myotubularin-like phosphatase domain Init_tRNA_PT PF04179.10 001105111.1_16124001_3 - 0.00015 21.9 0.0 0.98 9.6 0.0 2.6 2 1 0 2 2 2 2 Rit1 DUSP-like domain RAMP PF04901.11 001105111.1_16124001_3 - 0.024 14.5 1.1 12 5.8 0.0 3.3 4 0 0 4 4 4 0 Receptor activity modifying family DUF442 PF04273.11 001105111.1_16124001_3 - 0.038 13.9 0.0 12 5.9 0.0 2.5 2 0 0 2 2 2 0 Putative phosphatase (DUF442) YjeF_N PF03853.13 001105111.1_16124001_3 - 0.057 13.2 0.0 9.7 5.9 0.0 2.3 2 0 0 2 2 2 0 YjeF-related protein N-terminus Gal_Lectin PF02140.16 001105148.1_16122001_1 - 4.1e-23 81.5 7.7 4.1e-23 81.5 7.7 2.1 2 0 0 2 2 2 1 Galactose binding lectin domain Pkinase PF00069.23 200535.1_16124001_3 - 5e-67 225.9 0.0 6.1e-67 225.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 200535.1_16124001_3 - 4.9e-31 107.8 0.0 6.3e-31 107.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 200535.1_16124001_3 - 0.0013 18.0 0.0 0.0018 17.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 200535.1_16124001_3 - 0.0057 16.5 0.1 0.017 14.9 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family DSHCT PF08148.10 200535.1_16124001_3 - 0.035 13.6 0.0 0.056 13.0 0.0 1.2 1 0 0 1 1 1 0 DSHCT (NUC185) domain Filament PF00038.19 200568.1_16124001_1 - 1.6e-96 323.5 33.7 1.9e-96 323.2 33.7 1.1 1 0 0 1 1 1 1 Intermediate filament protein HXXSHH PF07586.9 200568.1_16124001_1 - 0.0071 15.8 0.3 0.019 14.4 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1552) ATG16 PF08614.9 200568.1_16124001_1 - 0.11 12.6 25.1 0.25 11.4 2.4 3.4 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DivIC PF04977.13 200568.1_16124001_1 - 0.13 11.9 22.1 2 8.1 2.8 5.3 3 1 1 4 4 4 0 Septum formation initiator DUF2461 PF09365.8 200568.1_16124001_1 - 0.25 11.1 2.8 12 5.7 0.1 3.4 2 1 1 4 4 4 0 Conserved hypothetical protein (DUF2461) DUF4140 PF13600.4 200568.1_16124001_1 - 0.29 11.5 15.1 8.7 6.7 6.2 4.6 2 1 3 5 5 5 0 N-terminal domain of unknown function (DUF4140) Spc7 PF08317.9 200568.1_16124001_1 - 0.38 9.4 30.0 0.022 13.5 3.0 3.0 1 1 2 3 3 3 0 Spc7 kinetochore protein Reo_sigmaC PF04582.10 200568.1_16124001_1 - 0.42 9.8 6.4 1.5 8.0 3.1 2.3 1 1 2 3 3 3 0 Reovirus sigma C capsid protein GAS PF13851.4 200568.1_16124001_1 - 1.4 8.1 33.2 6.4 6.0 0.8 4.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Macoilin PF09726.7 200568.1_16124001_1 - 3.8 5.8 18.5 0.99 7.7 3.5 2.4 1 1 1 2 2 2 0 Transmembrane protein Jnk-SapK_ap_N PF09744.7 200568.1_16124001_1 - 5.2 7.1 26.3 0.4 10.8 9.7 3.4 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 IncA PF04156.12 200568.1_16124001_1 - 6.8 6.3 32.2 2.6 7.7 2.6 3.8 1 1 2 4 4 4 0 IncA protein V_ATPase_I PF01496.17 200568.1_16124001_1 - 7.5 4.2 18.8 0.078 10.7 9.6 2.1 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family AIG1 PF04548.14 001109838.1_16122001_1 - 2.7e-59 199.9 1.1 3.3e-59 199.6 1.1 1.1 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.21 001109838.1_16122001_1 - 5e-11 42.6 0.2 1.8e-10 40.7 0.1 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.25 001109838.1_16122001_1 - 0.00015 22.1 0.7 0.00032 21.1 0.7 1.6 1 1 0 1 1 1 1 ABC transporter FeoB_N PF02421.16 001109838.1_16122001_1 - 0.00072 19.0 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B DUF258 PF03193.14 001109838.1_16122001_1 - 0.001 18.9 2.2 0.0022 17.8 0.3 2.3 2 2 1 3 3 3 1 Protein of unknown function, DUF258 EzrA PF06160.10 001109838.1_16122001_1 - 0.0015 16.7 1.6 0.0021 16.2 1.6 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Dynamin_N PF00350.21 001109838.1_16122001_1 - 0.0024 17.8 4.2 0.22 11.4 1.0 2.7 1 1 1 3 3 3 2 Dynamin family Septin PF00735.16 001109838.1_16122001_1 - 0.0031 16.7 0.2 0.0064 15.6 0.2 1.5 1 0 0 1 1 1 1 Septin Pup PF05639.9 001109838.1_16122001_1 - 0.014 16.1 1.7 0.015 16.1 0.1 1.9 2 0 0 2 2 1 0 Pup-like protein DUF2207 PF09972.7 001109838.1_16122001_1 - 0.032 12.9 0.0 0.047 12.3 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) AAA_24 PF13479.4 001109838.1_16122001_1 - 0.035 13.7 0.2 0.057 13.0 0.1 1.5 1 1 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.10 001109838.1_16122001_1 - 0.059 12.6 0.6 0.47 9.6 0.2 2.4 1 1 1 2 2 2 0 Gtr1/RagA G protein conserved region Roc PF08477.11 001109838.1_16122001_1 - 0.071 13.2 0.7 0.54 10.4 0.7 2.3 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.4 001109838.1_16122001_1 - 0.071 13.2 1.5 0.48 10.6 1.4 2.3 1 1 1 2 2 2 0 AAA domain Glyco_transf_41 PF13844.4 001017359.1_16127001_1 - 1.8e-247 821.2 0.8 7.5e-246 815.9 0.8 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 41 TPR_1 PF00515.26 001017359.1_16127001_1 - 6.7e-98 316.8 27.0 2.5e-10 39.6 0.3 13.2 13 0 0 13 13 13 11 Tetratricopeptide repeat TPR_11 PF13414.4 001017359.1_16127001_1 - 1.2e-92 303.2 32.4 8.6e-11 41.2 0.4 12.9 3 2 10 13 13 13 12 TPR repeat TPR_2 PF07719.15 001017359.1_16127001_1 - 4e-74 238.7 27.0 2.3e-08 33.4 0.4 13.0 13 0 0 13 13 12 11 Tetratricopeptide repeat TPR_17 PF13431.4 001017359.1_16127001_1 - 2.1e-67 218.7 29.4 7.9e-06 25.8 0.2 13.5 13 0 0 13 13 13 12 Tetratricopeptide repeat TPR_8 PF13181.4 001017359.1_16127001_1 - 5.6e-67 216.3 12.8 9.8e-07 28.4 0.1 13.5 14 0 0 14 14 14 11 Tetratricopeptide repeat TPR_12 PF13424.4 001017359.1_16127001_1 - 2.6e-48 162.1 27.4 1.3e-11 44.5 1.5 9.4 6 2 5 11 11 11 8 Tetratricopeptide repeat TPR_14 PF13428.4 001017359.1_16127001_1 - 1.1e-46 153.4 13.9 0.00043 20.7 0.1 12.1 5 3 7 12 12 12 10 Tetratricopeptide repeat TPR_19 PF14559.4 001017359.1_16127001_1 - 1.2e-44 150.5 18.5 3.5e-07 30.5 0.5 9.4 4 4 5 9 9 9 9 Tetratricopeptide repeat TPR_7 PF13176.4 001017359.1_16127001_1 - 8.2e-44 144.3 16.3 7e-05 22.5 0.1 13.0 13 1 1 14 14 13 9 Tetratricopeptide repeat TPR_16 PF13432.4 001017359.1_16127001_1 - 4.9e-43 145.4 11.3 1.9e-08 34.7 0.1 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_10 PF13374.4 001017359.1_16127001_1 - 1.4e-40 135.9 45.3 5.3e-07 29.2 0.4 12.2 12 0 0 12 12 12 7 Tetratricopeptide repeat TPR_9 PF13371.4 001017359.1_16127001_1 - 6.5e-18 64.5 13.1 0.0059 16.6 0.0 7.0 5 1 2 7 7 6 6 Tetratricopeptide repeat TPR_6 PF13174.4 001017359.1_16127001_1 - 5.9e-16 57.8 13.4 0.35 11.5 0.0 10.6 11 0 0 11 11 10 2 Tetratricopeptide repeat NARP1 PF12569.6 001017359.1_16127001_1 - 9.5e-16 57.6 5.5 0.00045 19.1 0.0 5.6 1 1 5 6 6 6 4 NMDA receptor-regulated protein 1 TPR_4 PF07721.12 001017359.1_16127001_1 - 2.5e-14 52.2 6.6 1.4 9.7 0.2 9.4 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_15 PF13429.4 001017359.1_16127001_1 - 2.3e-10 40.1 6.4 1.6e-05 24.2 1.0 4.8 1 1 4 5 5 5 2 Tetratricopeptide repeat FAT PF02259.21 001017359.1_16127001_1 - 3.7e-09 36.1 0.1 0.77 8.8 0.0 6.0 2 2 4 6 6 6 3 FAT domain MIT PF04212.16 001017359.1_16127001_1 - 2.3e-08 33.9 22.6 0.092 12.7 0.1 8.8 7 1 2 9 9 8 2 MIT (microtubule interacting and transport) domain TPR_21 PF09976.7 001017359.1_16127001_1 - 6.8e-07 29.1 9.6 0.17 11.5 0.0 5.2 3 2 2 5 5 5 3 Tetratricopeptide repeat-like domain TPR_3 PF07720.10 001017359.1_16127001_1 - 4.4e-06 26.4 4.7 1.1 9.1 0.0 6.1 7 1 0 7 7 5 2 Tetratricopeptide repeat Wzy_C_2 PF11846.6 001017359.1_16127001_1 - 3.6e-05 23.6 10.5 0.0036 17.1 0.4 4.4 4 1 2 6 6 5 1 Virulence factor membrane-bound polymerase, C-terminal SNAP PF14938.4 001017359.1_16127001_1 - 5.2e-05 22.7 15.8 0.017 14.4 4.4 4.5 1 1 4 5 5 5 2 Soluble NSF attachment protein, SNAP SHNi-TPR PF10516.7 001017359.1_16127001_1 - 0.00015 21.0 1.8 11 5.4 0.0 5.7 7 0 0 7 7 7 0 SHNi-TPR BTAD PF03704.15 001017359.1_16127001_1 - 0.0011 19.3 15.3 0.58 10.5 0.5 5.1 3 2 2 5 5 4 2 Bacterial transcriptional activator domain RPN7 PF10602.7 001017359.1_16127001_1 - 0.0046 16.5 10.4 19 4.7 0.1 6.8 4 2 5 9 9 9 0 26S proteasome subunit RPN7 ANAPC3 PF12895.5 001017359.1_16127001_1 - 0.0047 17.0 15.7 0.013 15.5 1.5 5.2 3 2 2 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_5 PF12688.5 001017359.1_16127001_1 - 0.0068 16.5 1.9 1.4 9.1 0.1 3.9 3 1 1 4 4 3 1 Tetratrico peptide repeat Mad3_BUB1_I PF08311.10 001017359.1_16127001_1 - 0.0073 16.2 4.9 34 4.3 0.0 6.2 5 1 2 7 7 6 0 Mad3/BUB1 homology region 1 PPR PF01535.18 001017359.1_16127001_1 - 0.0099 15.9 5.9 29 5.1 0.1 6.7 8 0 0 8 8 6 0 PPR repeat Tcf25 PF04910.12 001017359.1_16127001_1 - 0.013 14.5 0.2 0.054 12.4 0.0 2.1 2 0 0 2 2 2 0 Transcriptional repressor TCF25 EST1_DNA_bind PF10373.7 001017359.1_16127001_1 - 0.015 14.7 14.4 1.1 8.6 0.2 4.7 5 1 1 6 6 6 0 Est1 DNA/RNA binding domain TOM20_plant PF06552.10 001017359.1_16127001_1 - 0.059 13.0 0.4 27 4.3 0.0 4.0 2 1 1 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_20 PF14561.4 001017359.1_16127001_1 - 0.061 13.5 12.2 1.5 9.1 0.2 5.9 4 2 3 9 9 6 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 001017359.1_16127001_1 - 0.095 12.6 0.3 1 9.3 0.0 3.0 3 0 0 3 3 1 0 Fis1 C-terminal tetratricopeptide repeat Alkyl_sulf_dimr PF14863.4 001017359.1_16127001_1 - 0.1 12.9 1.7 7.7 6.8 0.5 3.2 2 1 0 2 2 2 0 Alkyl sulfatase dimerisation DUF627 PF04781.10 001017359.1_16127001_1 - 0.11 12.4 4.0 5.8 6.9 0.0 4.7 2 1 2 4 4 4 0 Protein of unknown function (DUF627) SUKH_5 PF14567.4 001017359.1_16127001_1 - 0.16 11.6 0.0 0.42 10.2 0.0 1.7 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall Sec16_C PF12931.5 001017359.1_16127001_1 - 0.32 10.4 1.7 11 5.4 0.0 2.7 2 1 1 3 3 3 0 Sec23-binding domain of Sec16 DUF5113 PF17140.2 001017359.1_16127001_1 - 1.5 8.5 12.5 31 4.2 0.3 5.5 3 2 4 7 7 7 0 Domain of unknown function (DUF5113) THAP PF05485.10 001017543.1_16123001_1 - 3.6e-07 30.9 3.1 3.9e-07 30.8 0.1 2.4 3 0 0 3 3 3 1 THAP domain RelB_transactiv PF16181.3 001017543.1_16123001_1 - 0.0017 18.5 0.1 0.0028 17.8 0.1 1.2 1 0 0 1 1 1 1 RelB transactivation domain zf-H2C2_2 PF13465.4 001109863.1_16124001_3 - 2e-54 179.5 96.7 1.5e-07 31.4 6.2 10.4 10 0 0 10 10 10 9 Zinc-finger double domain zf-C2H2 PF00096.24 001109863.1_16124001_3 - 4.2e-34 115.0 101.1 2.2e-07 30.8 1.4 10.4 11 0 0 11 11 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001109863.1_16124001_3 - 1.7e-20 71.8 88.9 0.00051 20.5 1.1 9.8 10 0 0 10 10 9 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001109863.1_16124001_3 - 1.1e-12 47.8 46.5 0.015 15.5 0.3 9.3 9 0 0 9 9 9 7 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.3 001109863.1_16124001_3 - 0.00055 20.2 70.6 0.18 12.1 0.8 9.3 2 2 6 8 8 7 6 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_15 PF17032.3 001109863.1_16124001_3 - 0.001 19.6 36.0 0.16 12.6 0.4 5.2 3 2 2 5 5 5 3 zinc-ribbon family C1_1 PF00130.20 001109863.1_16124001_3 - 0.0024 17.6 45.6 1.2 8.9 1.7 7.6 1 1 7 8 8 8 4 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_6 PF13912.4 001109863.1_16124001_3 - 0.0045 16.8 1.1 0.0045 16.8 1.1 9.6 10 0 0 10 10 8 6 C2H2-type zinc finger zf-LYAR PF08790.9 001109863.1_16124001_3 - 0.0075 16.0 47.2 0.5 10.2 0.7 8.8 9 0 0 9 9 9 4 LYAR-type C2HC zinc finger zf-C2H2_11 PF16622.3 001109863.1_16124001_3 - 0.023 14.3 55.1 0.12 12.0 1.5 8.2 8 0 0 8 8 8 0 zinc-finger C2H2-type zf-met PF12874.5 001109863.1_16124001_3 - 0.027 14.7 2.1 0.027 14.7 2.1 9.3 9 0 0 9 9 9 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 001109863.1_16124001_3 - 0.054 13.5 43.4 0.74 9.9 1.2 6.9 3 2 5 8 8 8 0 Zinc ribbon domain DUF3268 PF11672.6 001109863.1_16124001_3 - 0.7 10.1 23.0 3.6 7.8 3.0 4.2 2 2 3 5 5 5 0 zinc-finger-containing domain OAD_gamma PF04277.11 200633.1_16126001_1 - 2.7 8.5 5.3 5.3 7.6 5.3 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Ion_trans_2 PF07885.14 200633.1_16126001_2 - 1.7e-29 101.5 24.5 1.4e-16 60.1 2.3 3.0 3 0 0 3 3 3 2 Ion channel EF-hand_1 PF00036.30 200656.1_16126001_2 - 4.7e-18 63.2 12.7 2.1e-05 23.6 0.3 4.4 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 200656.1_16126001_2 - 5e-17 62.0 5.8 7.3e-12 45.5 0.2 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.4 200656.1_16126001_2 - 1e-15 56.1 7.4 0.00058 19.5 0.3 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 200656.1_16126001_2 - 8.2e-14 51.0 11.3 5e-06 26.1 0.8 3.4 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 200656.1_16126001_2 - 5.1e-13 47.8 6.8 7.3e-06 25.1 0.2 3.8 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.5 200656.1_16126001_2 - 0.0012 18.6 5.3 0.097 12.5 0.2 3.3 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 200656.1_16126001_2 - 0.019 15.1 0.7 0.28 11.4 0.1 2.5 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF4891 PF16232.3 200656.1_16126001_2 - 0.037 14.4 0.0 13 6.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4891) SCP2 PF02036.15 001110032.1_16124001_2 - 7.9e-17 61.5 0.0 1.6e-16 60.5 0.0 1.5 1 0 0 1 1 1 1 SCP-2 sterol transfer family Band_7 PF01145.23 001110032.1_16124001_2 - 2.6e-14 53.5 0.0 4.7e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family EutQ PF06249.10 001110032.1_16124001_2 - 0.049 13.2 0.0 0.093 12.4 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutQ BAR PF03114.16 001017617.1_16124001_1 - 4.8e-70 235.8 5.6 6.3e-70 235.4 5.6 1.1 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.4 001017617.1_16124001_1 - 1.1e-10 41.1 0.0 2.1e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain BAR_2 PF10455.7 001017617.1_16124001_1 - 2.8e-08 33.1 1.0 2.9e-08 33.0 0.1 1.4 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking SH3_1 PF00018.26 001017617.1_16124001_1 - 6e-07 28.8 0.0 1.3e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 SH3 domain BAR_3 PF16746.3 001017617.1_16124001_1 - 1.9e-06 27.6 2.2 3.2e-06 26.9 2.2 1.3 1 0 0 1 1 1 1 BAR domain of APPL family SH3_2 PF07653.15 001017617.1_16124001_1 - 0.00065 19.2 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Glyco_transf_10 PF00852.17 001017772.1_16123001_3 - 2.2e-59 200.0 0.5 3e-59 199.6 0.5 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 001017772.1_16123001_3 - 4.8e-33 113.8 0.2 1.1e-32 112.6 0.2 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal CTNNBL PF08216.9 200866.1_16125001_1 - 2.9e-40 136.5 1.0 7.9e-40 135.1 1.0 1.7 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.21 200866.1_16125001_1 - 0.011 15.6 0.3 0.32 11.0 0.2 2.8 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Peptidase_M41 PF01434.16 001111197.1_16127001_3 - 1.9e-75 253.0 0.1 2.7e-75 252.5 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.27 001111197.1_16127001_3 - 7e-42 142.8 0.0 1.4e-41 141.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.13 001111197.1_16127001_3 - 2.8e-08 34.0 0.6 6.7e-08 32.7 0.0 2.0 2 0 0 2 2 2 1 FtsH Extracellular AAA_22 PF13401.4 001111197.1_16127001_3 - 0.0012 19.0 0.0 0.088 12.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.12 001111197.1_16127001_3 - 0.0012 18.7 0.0 0.0048 16.8 0.0 2.1 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.12 001111197.1_16127001_3 - 0.0035 17.3 0.0 0.0074 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.4 001111197.1_16127001_3 - 0.0052 17.1 0.0 0.19 11.9 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain TIP49 PF06068.11 001111197.1_16127001_3 - 0.0088 14.9 0.0 0.015 14.2 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus RuvB_N PF05496.10 001111197.1_16127001_3 - 0.027 13.6 0.0 0.05 12.7 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.15 001111197.1_16127001_3 - 0.042 13.5 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.19 001111197.1_16127001_3 - 0.15 11.3 0.3 0.38 10.0 0.1 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI MITF_TFEB_C_3_N PF15951.3 131848.2_16125001_1 - 4.8e-47 160.3 14.7 4.8e-47 160.3 14.7 2.4 2 0 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus DUF3371 PF11851.6 131848.2_16125001_1 - 3.2e-28 99.2 7.7 3.2e-28 99.2 7.7 3.2 2 1 0 2 2 2 1 Domain of unknown function (DUF3371) HLH PF00010.24 131848.2_16125001_1 - 1.1e-14 54.0 0.5 3e-14 52.6 0.5 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Glyco_transf_41 PF13844.4 001018107.1_16127001_1 - 1.5e-252 837.9 0.0 2e-252 837.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 41 TPR_1 PF00515.26 001018107.1_16127001_1 - 4.8e-98 317.2 27.0 2.4e-10 39.7 0.3 13.2 13 0 0 13 13 13 11 Tetratricopeptide repeat TPR_11 PF13414.4 001018107.1_16127001_1 - 9.1e-93 303.6 32.4 8.4e-11 41.3 0.4 12.9 3 2 10 13 13 13 12 TPR repeat TPR_2 PF07719.15 001018107.1_16127001_1 - 1.2e-74 240.4 25.6 2.3e-08 33.4 0.4 13.1 13 0 0 13 13 12 11 Tetratricopeptide repeat TPR_17 PF13431.4 001018107.1_16127001_1 - 1.6e-67 219.1 29.4 7.7e-06 25.8 0.2 13.4 13 0 0 13 13 13 12 Tetratricopeptide repeat TPR_8 PF13181.4 001018107.1_16127001_1 - 3.3e-67 217.0 12.5 9.5e-07 28.4 0.1 13.5 14 0 0 14 14 14 11 Tetratricopeptide repeat TPR_12 PF13424.4 001018107.1_16127001_1 - 1.3e-48 163.1 27.0 1.8e-11 44.0 0.4 9.5 6 2 3 9 9 9 6 Tetratricopeptide repeat TPR_14 PF13428.4 001018107.1_16127001_1 - 8.1e-47 153.8 13.6 0.00041 20.8 0.1 12.1 5 3 7 12 12 12 10 Tetratricopeptide repeat TPR_19 PF14559.4 001018107.1_16127001_1 - 8.6e-45 151.0 18.4 3.4e-07 30.6 0.5 9.4 4 4 5 9 9 9 9 Tetratricopeptide repeat TPR_7 PF13176.4 001018107.1_16127001_1 - 6.6e-44 144.6 16.4 6.8e-05 22.5 0.1 13.0 13 1 1 14 14 13 9 Tetratricopeptide repeat TPR_16 PF13432.4 001018107.1_16127001_1 - 4e-43 145.7 11.3 1.9e-08 34.7 0.1 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_10 PF13374.4 001018107.1_16127001_1 - 8.9e-41 136.6 45.2 5.1e-07 29.2 0.4 12.3 12 0 0 12 12 12 7 Tetratricopeptide repeat TPR_9 PF13371.4 001018107.1_16127001_1 - 5.3e-18 64.8 13.1 0.0057 16.6 0.0 7.0 5 1 2 7 7 6 6 Tetratricopeptide repeat TPR_6 PF13174.4 001018107.1_16127001_1 - 4.6e-16 58.2 13.4 0.34 11.5 0.0 10.6 11 0 0 11 11 10 2 Tetratricopeptide repeat NARP1 PF12569.6 001018107.1_16127001_1 - 9.2e-16 57.7 5.5 0.00054 18.8 0.0 5.6 1 1 5 6 6 6 4 NMDA receptor-regulated protein 1 TPR_4 PF07721.12 001018107.1_16127001_1 - 1.1e-14 53.3 5.6 1.3 9.7 0.2 9.4 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_15 PF13429.4 001018107.1_16127001_1 - 1.9e-10 40.3 6.6 2.5e-05 23.5 0.8 4.9 1 1 2 4 4 4 2 Tetratricopeptide repeat FAT PF02259.21 001018107.1_16127001_1 - 3.3e-09 36.3 0.1 0.56 9.2 0.0 6.0 2 2 3 5 5 5 3 FAT domain MIT PF04212.16 001018107.1_16127001_1 - 1.7e-08 34.3 22.6 0.09 12.7 0.1 8.9 7 1 2 9 9 8 2 MIT (microtubule interacting and transport) domain TPR_21 PF09976.7 001018107.1_16127001_1 - 1e-06 28.5 10.4 0.16 11.6 0.0 5.2 3 2 2 5 5 5 3 Tetratricopeptide repeat-like domain TPR_3 PF07720.10 001018107.1_16127001_1 - 3.9e-06 26.6 4.7 1.1 9.2 0.0 6.1 7 1 0 7 7 5 2 Tetratricopeptide repeat Wzy_C_2 PF11846.6 001018107.1_16127001_1 - 3.1e-05 23.8 10.5 0.0035 17.2 0.4 4.5 4 1 2 6 6 5 1 Virulence factor membrane-bound polymerase, C-terminal SNAP PF14938.4 001018107.1_16127001_1 - 5.9e-05 22.5 16.1 0.015 14.6 4.3 4.5 1 1 2 4 4 4 2 Soluble NSF attachment protein, SNAP SHNi-TPR PF10516.7 001018107.1_16127001_1 - 0.00013 21.2 1.8 11 5.4 0.0 5.7 7 0 0 7 7 7 0 SHNi-TPR BTAD PF03704.15 001018107.1_16127001_1 - 0.00064 20.0 14.0 0.56 10.5 0.5 5.1 3 2 2 5 5 4 2 Bacterial transcriptional activator domain ANAPC3 PF12895.5 001018107.1_16127001_1 - 0.0038 17.3 15.6 0.012 15.6 1.4 5.2 3 2 2 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.7 001018107.1_16127001_1 - 0.0043 16.6 10.3 16 5.0 0.1 6.7 4 2 4 8 8 8 0 26S proteasome subunit RPN7 TPR_5 PF12688.5 001018107.1_16127001_1 - 0.005 16.9 1.8 1.3 9.1 0.1 4.1 3 1 1 4 4 3 1 Tetratrico peptide repeat Mad3_BUB1_I PF08311.10 001018107.1_16127001_1 - 0.0066 16.3 5.0 33 4.3 0.0 6.2 5 1 2 7 7 6 0 Mad3/BUB1 homology region 1 PPR PF01535.18 001018107.1_16127001_1 - 0.0083 16.2 5.9 28 5.1 0.1 6.8 8 0 0 8 8 6 0 PPR repeat Tcf25 PF04910.12 001018107.1_16127001_1 - 0.012 14.6 0.2 0.053 12.5 0.0 2.1 2 0 0 2 2 2 0 Transcriptional repressor TCF25 EST1_DNA_bind PF10373.7 001018107.1_16127001_1 - 0.014 14.8 14.5 1 8.6 0.2 4.7 5 1 1 6 6 6 0 Est1 DNA/RNA binding domain TPR_20 PF14561.4 001018107.1_16127001_1 - 0.033 14.4 11.7 1.4 9.1 0.2 6.0 4 2 3 8 8 6 0 Tetratricopeptide repeat TOM20_plant PF06552.10 001018107.1_16127001_1 - 0.052 13.2 0.4 28 4.3 0.0 4.0 2 1 1 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 Alkyl_sulf_dimr PF14863.4 001018107.1_16127001_1 - 0.058 13.7 1.9 7.5 6.9 0.5 3.3 2 1 0 2 2 2 0 Alkyl sulfatase dimerisation Fis1_TPR_C PF14853.4 001018107.1_16127001_1 - 0.089 12.7 0.3 1 9.4 0.0 3.1 3 0 0 3 3 1 0 Fis1 C-terminal tetratricopeptide repeat DUF627 PF04781.10 001018107.1_16127001_1 - 0.1 12.5 4.1 5.6 6.9 0.0 4.7 2 1 2 4 4 4 0 Protein of unknown function (DUF627) Sec16_C PF12931.5 001018107.1_16127001_1 - 0.29 10.6 1.6 10 5.5 0.0 2.7 2 1 1 3 3 3 0 Sec23-binding domain of Sec16 DUF5113 PF17140.2 001018107.1_16127001_1 - 1.1 8.9 12.3 30 4.3 0.3 5.6 3 2 4 7 7 7 0 Domain of unknown function (DUF5113) MAP7 PF05672.9 001113635.1_16126001_2 - 5e-42 143.3 75.1 5e-42 143.3 75.1 3.5 3 1 0 3 3 3 2 MAP7 (E-MAP-115) family Nse4_C PF08743.8 001020523.1_16123001_2 - 4.9e-27 93.9 0.0 1.2e-26 92.7 0.0 1.7 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.4 001020523.1_16123001_2 - 5.4e-15 55.1 0.2 1.4e-14 53.7 0.2 1.7 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE TipAS PF07739.11 001020523.1_16123001_2 - 0.69 10.3 2.3 11 6.4 0.1 2.8 2 1 0 2 2 2 0 TipAS antibiotic-recognition domain OmpH PF03938.12 001020523.1_16123001_2 - 3.1 7.6 6.4 0.28 11.0 1.0 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) NAD_binding_2 PF03446.13 201160.1_16123001_1 - 8.4e-49 165.6 0.3 1.4e-48 165.0 0.3 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.4 201160.1_16123001_1 - 4.8e-32 110.6 0.0 8.5e-32 109.8 0.0 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.17 201160.1_16123001_1 - 1.3e-08 34.3 0.0 2.6e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.15 201160.1_16123001_1 - 2.2e-07 31.2 0.2 5e-07 30.1 0.0 1.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.16 201160.1_16123001_1 - 0.0007 19.4 0.0 0.0013 18.5 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.10 201160.1_16123001_1 - 0.0028 17.1 0.1 0.0048 16.3 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Nitro_FeMo-Co PF02579.15 201160.1_16123001_1 - 0.0092 16.2 0.3 0.82 9.9 0.1 2.4 2 0 0 2 2 2 1 Dinitrogenase iron-molybdenum cofactor TrkA_N PF02254.16 201160.1_16123001_1 - 0.012 15.7 0.0 0.027 14.6 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain PDH PF02153.15 201160.1_16123001_1 - 0.025 13.4 0.1 0.043 12.7 0.1 1.4 1 0 0 1 1 1 0 Prephenate dehydrogenase UDPG_MGDP_dh_N PF03721.12 201160.1_16123001_1 - 0.089 12.2 0.0 0.48 9.8 0.0 2.0 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain WD40 PF00400.30 001020583.1_16126001_2 - 4.2e-33 112.7 12.8 1.3e-09 38.4 0.1 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001020583.1_16126001_2 - 7.3e-20 70.9 0.9 9.1e-08 32.2 0.0 4.0 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.9 001020583.1_16126001_2 - 2.4e-09 36.7 0.1 7.9e-09 35.1 0.1 1.9 2 0 0 2 2 2 1 LisH eIF2A PF08662.9 001020583.1_16126001_2 - 1.2e-06 28.5 0.9 0.0046 16.7 0.1 2.4 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.12 001020583.1_16126001_2 - 0.012 14.6 0.0 0.021 13.8 0.0 1.3 1 0 0 1 1 1 0 Coatomer WD associated region Ge1_WD40 PF16529.3 001020583.1_16126001_2 - 0.054 12.3 2.6 0.44 9.3 0.0 2.1 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Imm19 PF15563.4 201295.1_16125001_1 - 0.09 12.1 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 19 DUF1899 PF08953.9 201295.1_16125001_2 - 7e-32 109.0 0.1 1.4e-31 108.1 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 201295.1_16125001_2 - 5.9e-21 73.9 0.1 1.2e-20 73.0 0.1 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 201295.1_16125001_2 - 6e-16 58.4 6.7 5.2e-05 23.8 0.3 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 201295.1_16125001_2 - 2.1e-07 31.0 0.3 0.0018 18.4 0.0 2.8 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Trimer_CC PF08954.9 201295.1_16125001_2 - 0.006 16.0 0.6 0.42 10.1 0.6 2.3 2 0 0 2 2 2 1 Trimerisation motif Fib_alpha PF08702.8 201295.1_16125001_2 - 0.28 11.2 3.5 0.46 10.5 3.5 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family HAD_2 PF13419.4 001020615.1_16123001_2 - 7.3e-25 87.9 0.0 9.2e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.24 001020615.1_16123001_2 - 4e-11 43.5 0.0 1.1e-09 38.8 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.4 001020615.1_16123001_2 - 0.025 14.5 0.0 1.5 8.9 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase WBP-1 PF11669.6 001020631.1_16123001_3 - 4.1e-44 149.3 11.8 4.1e-44 149.3 11.8 2.3 3 0 0 3 3 3 1 WW domain-binding protein 1 TMEM52 PF14979.4 001020631.1_16123001_3 - 3.1 7.6 11.6 8.7 6.1 11.6 1.8 1 1 0 1 1 1 0 Transmembrane 52 B56 PF01603.18 194412.2_16124001_2 - 2.1e-193 642.8 10.8 2.7e-193 642.5 10.8 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.5 194412.2_16124001_2 - 0.068 13.0 5.7 2.1 8.2 0.8 3.1 2 1 1 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Metallophos PF00149.26 001114730.1_16127001_1 - 5.7e-26 92.2 0.1 8.3e-20 72.0 0.1 2.3 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase EF-hand_1 PF00036.30 001114730.1_16127001_1 - 6e-19 66.0 3.9 3.9e-06 25.9 0.2 3.5 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.4 001114730.1_16127001_1 - 4.1e-16 57.6 1.6 0.0001 21.5 0.2 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.4 001114730.1_16127001_1 - 6e-16 58.5 0.6 6.4e-11 42.4 1.5 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001114730.1_16127001_1 - 2.9e-15 54.7 1.2 0.00058 19.5 0.1 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.4 001114730.1_16127001_1 - 3e-11 42.8 1.1 9.7e-06 25.1 0.4 3.1 2 1 1 3 3 3 2 EF-hand domain pair PPP5 PF08321.10 001114730.1_16127001_1 - 8.1e-08 32.3 0.0 2.4e-07 30.8 0.0 1.8 1 0 0 1 1 1 1 PPP5 TPR repeat region IQ PF00612.25 001114730.1_16127001_1 - 0.0014 18.1 1.9 0.003 17.1 1.9 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif SPARC_Ca_bdg PF10591.7 001114730.1_16127001_1 - 0.064 13.4 0.0 14 5.9 0.0 2.6 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 001114730.1_16127001_1 - 1.1 9.2 4.7 3.1 7.7 0.3 3.1 3 1 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand DUF4515 PF14988.4 001114930.1_16124001_1 - 3.6e-19 69.3 28.3 3.6e-19 69.3 28.3 3.1 2 1 1 3 3 3 1 Domain of unknown function (DUF4515) Peptidase_Prp PF04327.10 001114930.1_16124001_1 - 1.2 9.3 3.8 3.7 7.7 0.1 3.1 2 0 0 2 2 2 0 Cysteine protease Prp Cadherin PF00028.15 001012658.2_16129001_1 - 7.3e-77 253.8 7.6 4.9e-18 65.2 0.0 6.4 6 0 0 6 6 6 5 Cadherin domain Cadherin_2 PF08266.10 001012658.2_16129001_1 - 1.7e-32 110.9 0.7 7e-29 99.3 0.0 3.5 4 0 0 4 4 4 2 Cadherin-like Cadherin_C_2 PF16492.3 001012658.2_16129001_1 - 7.4e-25 87.4 0.4 1.8e-24 86.2 0.4 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_tail PF15974.3 001012658.2_16129001_1 - 4.6e-18 65.7 9.7 4.6e-18 65.7 9.7 2.7 2 1 0 2 2 2 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_3 PF16184.3 001012658.2_16129001_1 - 0.0029 17.5 9.9 11 6.0 0.0 5.6 5 1 0 5 5 5 2 Cadherin-like Peptidase_S55 PF05580.10 001012658.2_16129001_1 - 0.0065 16.3 0.8 0.023 14.5 0.1 2.0 2 0 0 2 2 2 1 SpoIVB peptidase S55 TMEM154 PF15102.4 001012658.2_16129001_1 - 0.078 12.7 0.1 0.22 11.3 0.1 1.7 1 0 0 1 1 1 0 TMEM154 protein family Tctex-1 PF03645.11 205608.1_16123001_3 - 2.1e-28 98.4 1.5 3e-28 97.9 1.5 1.2 1 0 0 1 1 1 1 Tctex-1 family zf-RING_UBOX PF13445.4 001082859.2_16127001_1 - 6.8e-06 25.9 7.1 1.6e-05 24.6 7.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 001082859.2_16127001_1 - 7.2e-06 25.7 7.7 1.7e-05 24.5 7.7 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 001082859.2_16127001_1 - 1.6e-05 24.5 4.7 3.2e-05 23.6 4.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001082859.2_16127001_1 - 2.5e-05 24.2 5.5 5.4e-05 23.1 5.5 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.4 001082859.2_16127001_1 - 2.5e-05 23.9 6.6 0.00026 20.7 7.1 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.4 001082859.2_16127001_1 - 4.8e-05 23.4 7.2 9.3e-05 22.5 7.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.23 001082859.2_16127001_1 - 7.2e-05 22.4 8.5 0.00015 21.4 8.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.22 001082859.2_16127001_1 - 0.00017 21.3 2.7 0.00045 19.9 2.7 1.8 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) FYVE PF01363.19 001082859.2_16127001_1 - 0.002 18.1 0.5 0.0048 16.9 0.5 1.6 1 0 0 1 1 1 1 FYVE zinc finger Baculo_IE-1 PF05290.9 001082859.2_16127001_1 - 0.0041 17.0 0.8 0.011 15.6 0.8 1.6 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-C3HC4_2 PF13923.4 001082859.2_16127001_1 - 0.16 11.7 13.0 0.014 15.1 8.3 1.8 2 0 0 2 2 1 0 Zinc finger, C3HC4 type (RING finger) Fer2 PF00111.25 001082859.2_16127001_1 - 0.19 11.6 1.1 0.59 10.0 0.6 2.0 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain zf-RING_4 PF14570.4 001082859.2_16127001_1 - 0.38 10.4 4.9 0.78 9.4 4.9 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF4428 PF14471.4 001082859.2_16127001_1 - 0.39 10.5 1.6 1 9.2 1.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) zf-RING_10 PF16685.3 001082859.2_16127001_1 - 1.1 9.3 8.7 0.058 13.4 2.8 1.9 2 0 0 2 2 1 0 zinc RING finger of MSL2 zf-RING_11 PF17123.3 001082859.2_16127001_1 - 4.6 6.9 5.6 0.57 9.8 0.8 1.9 2 0 0 2 2 2 0 RING-like zinc finger Hydrolase_6 PF13344.4 001128705.1_16123001_2 - 2.8e-29 101.1 0.0 5.1e-29 100.2 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.4 001128705.1_16123001_2 - 5.3e-20 71.1 0.0 1e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.24 001128705.1_16123001_2 - 2.2e-09 37.8 0.0 9.5e-09 35.7 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.4 001128705.1_16123001_2 - 5e-05 23.3 0.0 0.019 14.9 0.0 2.8 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.8 001128705.1_16123001_2 - 0.041 13.4 0.0 0.086 12.3 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase STAS PF01740.19 001128705.1_16123001_2 - 0.066 12.7 0.0 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 STAS domain HAD PF12710.5 001128705.1_16123001_2 - 0.088 13.1 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DnaJ_C PF01556.16 212665.1_16126001_1 - 1.5e-41 141.8 0.1 2.1e-41 141.3 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.29 212665.1_16126001_1 - 1.7e-23 82.4 1.2 3e-23 81.6 1.2 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.17 212665.1_16126001_1 - 2e-16 60.0 17.8 4.2e-16 59.0 17.8 1.6 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.3 212665.1_16126001_1 - 0.71 9.7 12.3 4.1 7.3 1.8 2.6 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.17 212665.1_16126001_1 - 1.4 8.9 10.2 6.3 6.7 3.8 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA RseC_MucC PF04246.10 212665.1_16126001_1 - 9.8 6.0 7.1 0.77 9.6 1.3 2.0 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC RRM_1 PF00076.20 001030284.1_16124001_3 - 7.5e-54 179.3 0.5 2.4e-19 68.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 001030284.1_16124001_3 - 4.9e-08 32.8 0.9 0.00025 20.9 0.0 3.1 3 0 0 3 3 3 2 RNA binding motif Limkain-b1 PF11608.6 001030284.1_16124001_3 - 0.00026 20.9 0.0 0.37 10.8 0.0 2.8 2 1 0 2 2 2 2 Limkain b1 RRM_5 PF13893.4 001030284.1_16124001_3 - 0.0047 16.4 0.0 11 5.6 0.0 3.2 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.13 001030284.1_16124001_3 - 0.018 14.9 0.1 2.2 8.2 0.0 2.5 2 0 0 2 2 2 0 DbpA RNA binding domain SET_assoc PF11767.6 001030284.1_16124001_3 - 0.043 13.3 0.0 8.3 6.0 0.0 2.6 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated Pes-10 PF07149.9 001030284.1_16124001_3 - 0.09 11.7 2.2 0.7 8.7 2.1 1.9 2 0 0 2 2 2 0 Pes-10 CDC45 PF02724.12 001030284.1_16124001_3 - 8 4.5 7.9 11 4.0 7.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF525 PF04379.12 212714.1_16125001_3 - 4e-27 94.1 0.1 6.7e-27 93.4 0.1 1.3 1 0 0 1 1 1 1 ApaG domain YccV-like PF08755.9 212714.1_16125001_3 - 4.3e-12 46.3 0.3 1.1e-11 45.0 0.0 1.7 2 0 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like INSIG PF07281.10 212804.1_16123001_2 - 1.6e-46 158.5 7.9 8.1e-46 156.2 7.9 2.0 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) SLAC1 PF03595.15 212804.1_16123001_2 - 0.0052 16.1 9.0 0.017 14.4 9.2 1.6 1 1 0 1 1 1 1 Voltage-dependent anion channel DUF202 PF02656.13 212804.1_16123001_2 - 1.3 9.4 7.1 0.7 10.2 2.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF202) DUF1510 PF07423.9 212887.1_16123001_1 - 0.00087 18.7 11.1 0.00087 18.7 11.1 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1510) Zip PF02535.20 212887.1_16123001_1 - 0.12 11.5 2.7 0.15 11.1 2.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Connexin PF00029.17 212887.1_16123001_1 - 0.2 11.3 11.6 0.33 10.6 11.6 1.3 1 0 0 1 1 1 0 Connexin EOS1 PF12326.6 212887.1_16123001_1 - 0.29 10.9 7.1 0.47 10.2 7.1 1.3 1 0 0 1 1 1 0 N-glycosylation protein Folate_carrier PF01770.16 212887.1_16123001_1 - 0.75 8.3 8.9 0.95 8.0 8.9 1.1 1 0 0 1 1 1 0 Reduced folate carrier O-antigen_lig PF13425.4 212887.1_16123001_1 - 0.78 8.3 9.5 0.97 8.0 9.5 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CLN3 PF02487.15 212887.1_16123001_1 - 0.91 8.4 5.3 1.1 8.0 5.3 1.1 1 0 0 1 1 1 0 CLN3 protein DUF4834 PF16118.3 212887.1_16123001_1 - 2.1 9.2 18.5 0.065 14.1 11.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ureide_permease PF07168.9 212887.1_16123001_1 - 5.2 5.6 9.4 6.8 5.2 9.4 1.1 1 0 0 1 1 1 0 Ureide permease CS PF04969.14 212887.1_16123001_2 - 1.2e-13 51.7 0.2 2.4e-13 50.7 0.2 1.6 1 0 0 1 1 1 1 CS domain Siah-Interact_N PF09032.9 212887.1_16123001_2 - 2.7e-11 43.5 9.7 2.7e-11 43.5 9.7 3.5 3 1 0 3 3 3 1 Siah interacting protein, N terminal SGS PF05002.13 212887.1_16123001_2 - 4e-06 26.7 1.8 4e-06 26.7 1.8 3.8 3 1 0 3 3 3 1 SGS domain GhoS PF11080.6 212887.1_16123001_2 - 0.00011 22.0 0.1 0.00095 19.0 0.0 2.2 2 0 0 2 2 2 1 Endoribonuclease GhoS Syntaxin PF00804.23 212910.1_16123001_2 - 6e-65 218.6 12.6 8.9e-65 218.0 12.6 1.3 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.17 212910.1_16123001_2 - 5.7e-11 42.1 0.0 1.8e-10 40.5 0.0 1.9 1 0 0 1 1 1 1 SNARE domain YlqD PF11068.6 212910.1_16123001_2 - 0.026 14.8 1.4 0.026 14.8 1.4 2.8 1 1 3 4 4 4 0 YlqD protein Vps51 PF08700.9 212910.1_16123001_2 - 0.032 14.2 1.8 7.7 6.6 0.6 2.7 2 0 0 2 2 2 0 Vps51/Vps67 Laminin_II PF06009.10 212910.1_16123001_2 - 0.036 14.0 0.7 0.036 14.0 0.7 2.4 2 1 1 3 3 3 0 Laminin Domain II MCPsignal PF00015.19 212910.1_16123001_2 - 0.08 12.6 5.1 1.3 8.6 1.6 2.3 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain MbeD_MobD PF04899.10 212910.1_16123001_2 - 0.081 12.9 0.9 0.18 11.8 0.1 2.0 2 0 0 2 2 2 0 MbeD/MobD like GCN5L1 PF06320.11 212910.1_16123001_2 - 0.17 11.9 4.3 0.18 11.9 0.2 2.7 2 1 1 3 3 3 0 GCN5-like protein 1 (GCN5L1) BLOC1_2 PF10046.7 212910.1_16123001_2 - 2.2 8.5 10.1 1.3 9.3 1.3 3.6 3 2 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FlxA PF14282.4 212910.1_16123001_2 - 2.7 7.9 6.8 0.98 9.3 2.2 2.6 2 1 0 2 2 2 0 FlxA-like protein ATG16 PF08614.9 212910.1_16123001_2 - 2.8 8.0 8.1 0.42 10.6 3.2 2.0 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Peptidase_C2 PF00648.19 212939.1_16125001_2 - 3.7e-102 341.2 0.0 6.7e-102 340.4 0.0 1.4 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 212939.1_16125001_2 - 1.3e-20 74.0 0.0 2.5e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_6 PF13405.4 212939.1_16125001_2 - 2.5e-05 23.7 0.0 2.5 8.1 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 212939.1_16125001_2 - 0.0023 18.3 0.1 18 5.8 0.0 3.7 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_1 PF00036.30 212939.1_16125001_2 - 0.0086 15.4 0.0 12 5.6 0.0 3.4 3 0 0 3 3 3 1 EF hand Uroplakin_II PF07353.10 001135982.1_16121001_2 - 4.2e-13 49.1 5.6 8.2e-10 38.3 2.1 2.0 1 1 1 2 2 2 2 Uroplakin II Rax2 PF12768.5 001135982.1_16121001_2 - 0.0038 16.7 0.3 0.0052 16.3 0.3 1.1 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Pox_A9 PF04835.10 001135982.1_16121001_2 - 0.037 14.0 3.7 0.074 13.1 3.7 1.4 1 0 0 1 1 1 0 A9 protein conserved region DUF4711 PF15829.3 001135982.1_16121001_2 - 0.049 13.4 0.1 0.057 13.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4711) DUF2892 PF11127.6 001135982.1_16121001_2 - 0.085 12.8 1.5 0.15 12.0 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2892) DUF3377 PF11857.6 001135982.1_16121001_2 - 0.16 11.8 0.4 0.26 11.1 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) IRS PF02174.15 213088.1_16125001_3 - 2.3e-35 120.4 0.0 5.1e-35 119.2 0.0 1.6 1 0 0 1 1 1 1 PTB domain (IRS-1 type) PH PF00169.27 213088.1_16125001_3 - 9.4e-10 38.8 0.5 2e-09 37.8 0.5 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 213088.1_16125001_3 - 0.011 16.0 2.1 0.098 13.0 2.1 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain Cyt-b5 PF00173.26 213104.1_16125001_3 - 3.1e-11 43.1 0.0 5.2e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain 7tm_2 PF00002.22 001013444.2_16124001_1 - 5.9e-94 313.8 14.4 9.5e-94 313.1 14.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001013444.2_16124001_1 - 1.7e-22 79.3 3.9 1.7e-22 79.3 3.9 2.4 2 0 0 2 2 2 1 Hormone receptor domain zf-FCS PF06467.12 213197.1_16124001_1 - 0.18 11.7 7.1 0.67 9.8 1.3 2.6 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif CENP-B_dimeris PF09026.8 213197.1_16124001_1 - 0.26 11.6 3.4 0.46 10.8 3.4 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain zf-Di19 PF05605.10 213197.1_16124001_1 - 0.69 10.1 5.4 2.5 8.3 0.1 2.2 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Cys_knot PF00007.20 001166338.1_16121001_1 - 7.2e-19 67.9 3.9 7.2e-19 67.9 3.9 1.4 2 0 0 2 2 2 1 Cystine-knot domain Ig_3 PF13927.4 001113551.2_16123001_1 - 1.4e-30 105.6 1.8 8.1e-13 48.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 001113551.2_16123001_1 - 9.3e-26 89.6 0.2 5.3e-10 39.1 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.4 001113551.2_16123001_1 - 6.7e-24 83.9 0.1 1.6e-08 34.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 001113551.2_16123001_1 - 7.8e-23 80.3 0.2 8.5e-08 32.1 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.10 001113551.2_16123001_1 - 2e-16 59.7 0.1 7.6e-14 51.4 0.0 3.2 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 001113551.2_16123001_1 - 2.9e-16 59.4 1.3 1.3e-07 31.6 0.0 4.5 3 1 1 4 4 4 4 Immunoglobulin V-set domain C1-set PF07654.13 001113551.2_16123001_1 - 8.2e-07 29.3 0.3 0.0036 17.6 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin C1-set domain Ig_5 PF16681.3 001113551.2_16123001_1 - 2.1e-06 27.9 0.7 0.14 12.4 0.0 3.7 3 1 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Adeno_E3_CR1 PF02440.13 001113551.2_16123001_1 - 0.013 15.1 0.2 3.1 7.5 0.1 3.2 2 1 0 2 2 2 0 Adenovirus E3 region protein CR1 Izumo-Ig PF16706.3 001113551.2_16123001_1 - 0.023 14.6 0.1 2 8.4 0.0 3.1 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain TMEM154 PF15102.4 001113551.2_16123001_1 - 0.033 13.9 0.1 0.08 12.7 0.1 1.6 1 0 0 1 1 1 0 TMEM154 protein family DUF4307 PF14155.4 001113551.2_16123001_1 - 0.039 13.7 3.1 3.8 7.2 0.0 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4307) V-set_2 PF15910.3 001113551.2_16123001_1 - 0.087 12.8 0.2 14 5.6 0.1 2.9 2 1 1 3 3 3 0 ICOS V-set domain OAD_gamma PF04277.11 001113551.2_16123001_1 - 0.21 12.1 0.7 1.1 9.8 0.0 2.4 2 1 1 3 3 3 0 Oxaloacetate decarboxylase, gamma chain Filament PF00038.19 001044910.1_16123001_2 - 6.2e-84 282.1 36.3 7.6e-84 281.8 36.3 1.1 1 0 0 1 1 1 1 Intermediate filament protein Lectin_N PF03954.12 001044910.1_16123001_2 - 0.00065 19.3 11.8 0.0076 15.9 0.4 3.7 2 1 1 3 3 3 2 Hepatic lectin, N-terminal domain ABC_tran_CTD PF16326.3 001044910.1_16123001_2 - 0.0012 18.9 3.8 0.0012 18.9 3.8 4.9 2 2 1 4 4 4 2 ABC transporter C-terminal domain IncA PF04156.12 001044910.1_16123001_2 - 0.0056 16.4 36.0 1.2 8.8 22.2 3.4 1 1 2 3 3 3 2 IncA protein ATG16 PF08614.9 001044910.1_16123001_2 - 0.0077 16.3 13.6 0.0077 16.3 13.6 4.1 1 1 4 5 5 5 1 Autophagy protein 16 (ATG16) DUF1664 PF07889.10 001044910.1_16123001_2 - 0.016 15.1 1.3 0.016 15.1 1.3 4.3 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) Sel1 PF08238.10 001044910.1_16123001_2 - 0.14 12.8 0.1 5.3 7.7 0.0 2.5 2 0 0 2 2 2 0 Sel1 repeat Reo_sigmaC PF04582.10 001044910.1_16123001_2 - 0.23 10.7 11.9 0.13 11.5 1.7 2.9 1 1 0 2 2 2 0 Reovirus sigma C capsid protein CEP63 PF17045.3 001044910.1_16123001_2 - 0.38 10.5 30.0 0.085 12.6 12.9 3.4 1 1 1 3 3 3 0 Centrosomal protein of 63 kDa Baculo_PEP_C PF04513.10 001044910.1_16123001_2 - 0.52 10.2 12.4 0.37 10.7 0.4 4.0 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.9 001044910.1_16123001_2 - 0.54 9.0 34.0 0.15 10.8 11.6 3.7 1 1 3 4 4 4 0 Spc7 kinetochore protein DUF4686 PF15742.3 001044910.1_16123001_2 - 0.55 9.1 32.7 0.13 11.2 27.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4686) WXG100 PF06013.10 001044910.1_16123001_2 - 0.61 10.2 12.7 0.28 11.3 2.3 3.6 3 1 1 4 4 3 0 Proteins of 100 residues with WXG ADIP PF11559.6 001044910.1_16123001_2 - 0.65 9.9 33.2 0.53 10.2 4.0 4.1 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding KxDL PF10241.7 001044910.1_16123001_2 - 1.1 9.5 22.2 0.15 12.2 1.4 4.7 4 1 1 5 5 4 0 Uncharacterized conserved protein Golgin_A5 PF09787.7 001044910.1_16123001_2 - 2.6 7.3 33.7 2.1 7.6 2.9 3.8 1 1 4 5 5 5 0 Golgin subfamily A member 5 APG6 PF04111.10 001044910.1_16123001_2 - 4.4 6.5 30.0 0.16 11.2 12.9 2.7 2 1 0 2 2 2 0 Autophagy protein Apg6 DUF4407 PF14362.4 001044910.1_16123001_2 - 6.2 5.9 20.7 2.4 7.3 12.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) CENP-F_leu_zip PF10473.7 001044910.1_16123001_2 - 7.3 6.5 41.5 3.9 7.4 5.8 4.5 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Laminin_II PF06009.10 001044910.1_16123001_2 - 8.1 6.3 16.3 5.2 7.0 3.9 3.4 3 1 1 4 4 4 0 Laminin Domain II Prefoldin PF02996.15 001044910.1_16123001_2 - 9.7 6.0 24.3 0.23 11.2 1.9 5.5 3 1 1 5 5 5 0 Prefoldin subunit IRK PF01007.18 001045178.1_16124001_3 - 1.6e-125 418.3 0.0 2e-125 418.0 0.0 1.0 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 001045178.1_16124001_3 - 0.00065 19.5 3.3 0.0015 18.4 3.3 1.6 1 0 0 1 1 1 1 Ion channel MaAIMP_sms PF16951.3 001045178.1_16124001_3 - 0.0031 17.1 1.1 0.0066 16.0 1.1 1.5 1 0 0 1 1 1 1 Putative methionine and alanine importer, small subunit Lipocalin PF00061.21 001001842.1_16122001_1 - 5.7e-22 78.3 0.6 7.2e-22 78.0 0.6 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001001842.1_16122001_1 - 1.1e-05 25.2 0.0 1.6e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family RPA_interact_N PF14766.4 001045388.1_16122001_1 - 1e-19 69.8 4.7 1.8e-19 69.0 4.7 1.4 1 0 0 1 1 1 1 Replication protein A interacting N-terminal RPA_interact_C PF14768.4 001045388.1_16122001_1 - 6.5e-19 68.2 5.7 1.3e-18 67.2 5.7 1.5 1 0 0 1 1 1 1 Replication protein A interacting C-terminal RPA_interact_M PF14767.4 001045388.1_16122001_1 - 1.4e-17 63.9 5.3 2.5e-17 63.1 5.3 1.4 1 0 0 1 1 1 1 Replication protein A interacting middle ICAT PF06384.9 001045388.1_16122001_1 - 0.082 13.1 0.9 0.64 10.2 0.3 2.3 2 0 0 2 2 2 0 Beta-catenin-interacting protein ICAT PQ-loop PF04193.12 001002130.1_16125001_2 - 8.1e-19 67.0 10.0 3.7e-13 48.9 1.5 3.2 3 0 0 3 3 3 2 PQ loop repeat DUF3054 PF11255.6 001002130.1_16125001_2 - 0.036 14.4 0.9 0.088 13.2 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3054) ADIP PF11559.6 102278.1_16122120_3 - 5e-30 104.5 13.9 5e-30 104.5 13.9 1.9 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding L31 PF09784.7 102278.1_16122120_3 - 0.36 11.1 4.4 1.1 9.6 4.3 1.9 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L31 SseC PF04888.10 102278.1_16122120_3 - 0.39 10.0 2.1 0.74 9.1 2.1 1.4 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Cnn_1N PF07989.9 102278.1_16122120_3 - 1.2 9.1 18.1 0.28 11.2 0.4 3.0 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 ERM PF00769.17 102278.1_16122120_3 - 2.5 7.7 25.2 5.8 6.5 25.2 1.5 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF4407 PF14362.4 102278.1_16122120_3 - 4.3 6.5 8.1 9.2 5.4 8.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Syntaxin-6_N PF09177.9 102278.1_16122120_3 - 5.6 7.4 12.2 1.5 9.3 7.5 2.3 2 1 0 2 2 2 0 Syntaxin 6, N-terminal DivIVA PF05103.11 102278.1_16122120_3 - 8.8 6.3 14.8 2.4 8.1 8.9 2.2 2 0 0 2 2 2 0 DivIVA protein SWIM PF04434.15 111928.1_16122120_2 - 0.0081 15.7 1.9 0.02 14.4 1.9 1.7 1 0 0 1 1 1 1 SWIM zinc finger AIG1 PF04548.14 024238.1_16123120_3 - 5.5e-07 29.0 0.7 0.00058 19.1 0.2 2.1 2 0 0 2 2 2 2 AIG1 family CUB PF00431.18 027750.1_16125120_1 - 2.4e-09 37.4 0.0 2.1e-06 27.9 0.0 2.3 2 0 0 2 2 2 2 CUB domain EGF_CA PF07645.13 027750.1_16125120_1 - 1.7e-07 31.2 11.8 1.7e-07 31.2 11.8 2.5 2 0 0 2 2 2 1 Calcium-binding EGF domain FXa_inhibition PF14670.4 027750.1_16125120_1 - 4.2e-06 26.8 10.3 4.2e-06 26.8 10.3 2.1 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site cEGF PF12662.5 027750.1_16125120_1 - 0.0048 16.7 3.8 0.0048 16.7 3.8 2.7 3 0 0 3 3 3 1 Complement Clr-like EGF-like Trypsin PF00089.24 027750.1_16125120_2 - 9.3e-49 166.1 0.0 1.3e-48 165.6 0.0 1.2 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 027750.1_16125120_2 - 6e-10 39.3 0.0 1.2e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 CUB domain Sushi PF00084.18 027750.1_16125120_2 - 5e-09 36.5 1.8 0.0011 19.5 0.2 2.8 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) HRM PF02793.20 027750.1_16125120_2 - 0.0045 17.1 1.7 2 8.6 0.1 2.5 2 0 0 2 2 2 2 Hormone receptor domain Trypsin_2 PF13365.4 027750.1_16125120_2 - 0.069 13.9 0.0 0.14 12.9 0.0 1.4 1 0 0 1 1 1 0 Trypsin-like peptidase domain zf-H2C2_2 PF13465.4 001328705.1_16124001_1 - 4.8e-83 270.0 66.4 4.5e-10 39.4 0.6 11.2 11 0 0 11 11 11 10 Zinc-finger double domain zf-C2H2 PF00096.24 001328705.1_16124001_1 - 1.1e-63 208.2 85.7 1.4e-07 31.4 1.9 10.7 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001328705.1_16124001_1 - 2.3e-43 142.9 76.0 6.9e-05 23.2 1.0 10.8 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001328705.1_16124001_1 - 1.1e-20 72.9 64.1 0.0024 17.6 0.7 10.8 10 1 0 10 10 10 10 C2H2-type zinc finger zf-LYAR PF08790.9 001328705.1_16124001_1 - 2.6e-17 62.3 61.3 0.033 14.0 0.5 10.5 10 0 0 10 10 10 9 LYAR-type C2HC zinc finger zf-C2H2_11 PF16622.3 001328705.1_16124001_1 - 1.7e-13 49.9 75.4 0.0012 18.4 3.9 10.3 10 0 0 10 10 10 6 zinc-finger C2H2-type zf-C2HE PF16278.3 001328705.1_16124001_1 - 2.2e-10 40.7 72.3 0.054 13.8 0.4 10.3 1 1 9 10 10 10 6 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.6 001328705.1_16124001_1 - 8.7e-10 38.5 36.5 0.052 13.7 0.1 10.3 10 0 0 10 10 10 1 Zinc-finger double-stranded RNA-binding ADK_lid PF05191.12 001328705.1_16124001_1 - 3.4e-07 30.0 24.3 0.43 10.5 0.1 8.2 5 2 3 8 8 8 3 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.8 001328705.1_16124001_1 - 2.7e-06 27.3 40.1 0.34 10.9 1.1 7.3 1 1 9 10 10 10 7 Zinc ribbon domain HypA PF01155.17 001328705.1_16124001_1 - 6.1e-06 26.1 31.9 0.092 12.6 3.2 6.0 1 1 5 6 6 6 5 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_2 PF12756.5 001328705.1_16124001_1 - 7.7e-05 22.8 55.0 1.6 9.0 0.8 10.1 1 1 9 10 10 10 1 C2H2 type zinc-finger (2 copies) zf-Sec23_Sec24 PF04810.13 001328705.1_16124001_1 - 0.00013 21.8 43.0 1.4 8.9 0.2 10.0 5 4 5 10 10 10 2 Sec23/Sec24 zinc finger GAGA PF09237.9 001328705.1_16124001_1 - 0.00028 20.5 11.7 10 5.9 0.0 7.2 1 1 7 8 8 8 0 GAGA factor zf-trcl PF13451.4 001328705.1_16124001_1 - 0.00062 19.5 50.1 3 7.7 0.1 10.4 9 1 0 9 9 9 1 Probable zinc-ribbon domain zf-RING_7 PF02591.13 001328705.1_16124001_1 - 0.00078 19.4 22.1 21 5.3 0.0 9.5 10 0 0 10 10 10 0 C4-type zinc ribbon domain YhfH PF14149.4 001328705.1_16124001_1 - 0.00093 19.0 40.1 12 5.9 0.1 9.8 10 0 0 10 10 10 0 YhfH-like protein zf-AN1 PF01428.14 001328705.1_16124001_1 - 0.0018 18.2 60.7 0.79 9.8 4.6 10.3 8 2 2 10 10 10 1 AN1-like Zinc finger zinc_ribbon_15 PF17032.3 001328705.1_16124001_1 - 0.0059 17.2 38.3 1.7 9.3 3.1 5.9 1 1 5 6 6 6 2 zinc-ribbon family zf-H2C2_5 PF13909.4 001328705.1_16124001_1 - 0.0065 16.1 0.9 0.0065 16.1 0.9 11.3 11 2 0 11 11 9 4 C2H2-type zinc-finger domain PknG_rubred PF16919.3 001328705.1_16124001_1 - 0.015 15.2 31.5 0.58 10.1 0.6 6.0 1 1 5 6 6 6 0 Protein kinase G rubredoxin domain LIM PF00412.20 001328705.1_16124001_1 - 0.072 13.2 53.0 10 6.3 0.1 9.7 3 1 6 10 10 10 0 LIM domain zf-CHY PF05495.10 001328705.1_16124001_1 - 0.1 13.1 50.2 1.3 9.5 4.8 6.3 1 1 6 7 7 7 0 CHY zinc finger zf-BED PF02892.13 001328705.1_16124001_1 - 0.59 10.1 61.4 0.058 13.3 2.1 9.3 1 1 9 10 10 10 0 BED zinc finger stn_TNFRSF12A PF12191.6 001328705.1_16124001_1 - 0.84 9.7 2.9 52 3.9 0.0 4.2 2 1 3 6 6 6 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain CpXC PF14353.4 001328705.1_16124001_1 - 1.3 8.9 42.7 7.4 6.5 0.9 9.0 1 1 7 8 8 8 0 CpXC protein BolA PF01722.16 001328705.1_16124001_1 - 1.5 9.0 10.1 34 4.7 0.1 5.0 1 1 5 7 7 7 0 BolA-like protein DUF3268 PF11672.6 001328705.1_16124001_1 - 2.1 8.6 24.9 8.4 6.6 1.4 5.2 1 1 0 5 5 5 0 zinc-finger-containing domain PLCC PF14466.4 001328705.1_16124001_1 - 2.9 7.9 4.6 18 5.3 0.2 3.4 1 1 3 5 5 5 0 PLAT/LH2 and C2-like Ca2+-binding lipoprotein zf-C2HC_2 PF13913.4 001328705.1_16124001_1 - 3.6 7.5 48.9 0.55 10.1 0.5 9.1 9 0 0 9 9 9 0 zinc-finger of a C2HC-type C1_4 PF07975.10 001328705.1_16124001_1 - 3.7 7.8 43.4 2.2 8.5 1.3 6.6 4 1 3 8 8 7 0 TFIIH C1-like domain zf-FCS PF06467.12 001328705.1_16124001_1 - 4.1 7.3 53.6 12 5.8 0.3 9.1 9 0 0 9 9 9 0 MYM-type Zinc finger with FCS sequence motif Elf1 PF05129.11 001328705.1_16124001_1 - 6.9 6.7 44.6 2.4 8.1 4.6 6.0 1 1 6 7 7 7 0 Transcription elongation factor Elf1 like zf-H2C2_2 PF13465.4 001328705.1_16124001_2 - 4.4e-12 45.7 8.6 8.6e-07 29.0 0.2 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.24 001328705.1_16124001_2 - 1.9e-08 34.2 11.1 0.00068 19.8 0.5 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001328705.1_16124001_2 - 0.0011 19.5 9.5 0.098 13.4 0.2 3.9 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001328705.1_16124001_2 - 0.058 13.6 7.0 0.92 9.8 0.4 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Endonuclease_7 PF02945.13 001328705.1_16124001_2 - 0.12 12.1 0.7 0.28 11.0 0.7 1.5 1 0 0 1 1 1 0 Recombination endonuclease VII Pkinase PF00069.23 001025456.1_16126001_1 - 4.9e-72 242.3 0.0 6.5e-72 241.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001025456.1_16126001_1 - 5.7e-46 156.8 0.0 8.3e-46 156.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 001025456.1_16126001_1 - 2.8e-24 85.2 0.1 5.7e-24 84.2 0.1 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 001025456.1_16126001_1 - 1.8e-07 30.7 0.1 0.00077 18.7 0.0 2.2 1 1 1 2 2 2 2 Kinase-like APH PF01636.21 001025456.1_16126001_1 - 0.0067 16.2 0.0 0.097 12.4 0.1 2.0 1 1 1 2 2 2 2 Phosphotransferase enzyme family Spt5_N PF11942.6 001025456.1_16126001_1 - 0.0088 16.9 1.8 0.019 15.8 1.8 1.5 1 0 0 1 1 1 1 Spt5 transcription elongation factor, acidic N-terminal Kdo PF06293.12 001025456.1_16126001_1 - 0.061 12.5 0.0 0.099 11.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TFIIE-A_C PF11521.6 001025456.1_16126001_1 - 0.8 10.0 7.1 0.21 11.8 3.2 2.0 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha Cwf_Cwc_15 PF04889.10 001025456.1_16126001_1 - 1.7 8.2 5.3 2.8 7.5 5.3 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.4 001025456.1_16126001_1 - 5.3 7.4 8.5 1.4 9.2 4.6 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.8 001025456.1_16126001_1 - 8.5 6.7 9.3 18 5.7 9.3 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain L51_S25_CI-B8 PF05047.14 001277840.1_23522001_2 - 1e-11 44.4 0.1 1.7e-11 43.7 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Ribosomal_S10 PF00338.20 001277576.1_23522001_3 - 5e-26 90.7 0.2 6.9e-26 90.2 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e NDK PF00334.17 001002516.1_16122001_1 - 3.3e-39 133.9 0.0 4.1e-39 133.5 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Dpy-30 PF05186.11 001002516.1_16122001_1 - 1.5e-15 56.5 0.2 2.5e-15 55.7 0.2 1.4 1 0 0 1 1 1 1 Dpy-30 motif Ribosomal_S21 PF01165.18 001277967.1_23521001_3 - 2.1e-18 65.7 0.1 2.9e-18 65.2 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S21 Ribosomal_L27A PF00828.17 001277663.1_23522001_3 - 5.5e-25 88.3 0.0 7.6e-25 87.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ribosomal_L13 PF00572.16 001277471.1_23522001_1 - 3.8e-47 159.5 0.0 5.2e-47 159.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L13 p450 PF00067.20 001329504.1_23524001_3 - 8.7e-131 436.7 0.4 1e-130 436.5 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ribosomal_S3Ae PF01015.16 001082417.2_23522001_2 - 4.2e-108 359.5 8.9 5e-108 359.3 8.9 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.14 001082417.2_23522001_2 - 0.0057 16.1 0.2 0.028 13.9 0.1 2.2 1 1 1 2 2 2 1 Partial alpha/beta-hydrolase lipase region Orexin PF02072.13 001279703.1_37522001_3 - 4.2e-24 84.8 5.4 2.2e-23 82.5 5.4 1.8 1 1 0 1 1 1 1 Prepro-orexin adh_short PF00106.23 001279795.1_37524001_1 - 4.2e-41 140.4 0.0 5.5e-41 140.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001279795.1_37524001_1 - 5.1e-26 91.5 0.0 7.2e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001279795.1_37524001_1 - 2.2e-06 27.6 0.1 4.2e-06 26.7 0.1 1.5 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.8 001279795.1_37524001_1 - 0.0014 17.9 0.1 0.0022 17.3 0.1 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.6 001279795.1_37524001_1 - 0.0049 16.5 0.3 0.02 14.5 0.0 2.0 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase adh_short_C2 PF13561.4 001279536.1_37522001_2 - 1.4e-63 214.5 0.7 1.8e-63 214.1 0.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 001279536.1_37522001_2 - 4.6e-52 176.2 1.2 5.6e-52 175.9 1.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 001279536.1_37522001_2 - 3.8e-19 69.2 1.2 5.5e-19 68.6 1.2 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.13 001279536.1_37522001_2 - 1.3e-05 24.4 0.3 2e-05 23.8 0.3 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.19 001279536.1_37522001_2 - 0.00053 19.4 0.1 0.0011 18.3 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.16 001279536.1_37522001_2 - 0.002 17.9 0.0 0.0034 17.2 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3Beta_HSD PF01073.17 001279536.1_37522001_2 - 0.0062 15.4 0.2 0.008 15.1 0.2 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family F420_oxidored PF03807.15 001279536.1_37522001_2 - 0.018 15.4 0.5 0.41 11.1 0.0 2.4 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent RmlD_sub_bind PF04321.15 001279536.1_37522001_2 - 0.093 11.7 0.1 0.18 10.8 0.1 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain BNR_2 PF13088.4 001293132.1_02224001_1 - 4.7e-34 117.8 0.0 9.5e-29 100.4 0.0 2.1 2 0 0 2 2 2 2 BNR repeat-like domain BNR_3 PF13859.4 001293132.1_02224001_1 - 1e-06 28.2 0.0 1.3e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.18 001293132.1_02224001_1 - 0.00063 19.2 12.4 0.05 13.5 1.2 4.1 4 0 0 4 4 4 2 BNR/Asp-box repeat Cys_knot PF00007.20 001279743.1_37521001_2 - 2.6e-15 56.5 10.2 3.2e-15 56.2 10.2 1.1 1 0 0 1 1 1 1 Cystine-knot domain DNA_methylase PF00145.15 001293127.1_02226001_1 - 8.6e-17 61.3 0.1 1.1e-12 47.8 0.0 2.6 3 0 0 3 3 3 2 C-5 cytosine-specific DNA methylase PWWP PF00855.15 001293127.1_02226001_1 - 4.1e-11 43.1 0.3 1.4e-10 41.4 0.3 1.9 1 0 0 1 1 1 1 PWWP domain zf-C4 PF00105.16 001290066.1_37524001_3 - 2.8e-28 98.0 16.3 5.8e-28 97.0 16.3 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001290066.1_37524001_3 - 3.5e-17 62.6 0.1 1.5e-16 60.4 0.1 1.9 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor p450 PF00067.20 001099358.1_23523001_1 - 6.1e-82 275.7 0.0 7.7e-82 275.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 eIF-6 PF01912.16 001030848.1_23525001_3 - 4.3e-79 264.4 0.2 9.3e-79 263.3 0.1 1.6 2 0 0 2 2 2 1 eIF-6 family p450 PF00067.20 138143.1_23524120_3 - 8e-16 57.7 0.4 1e-10 40.9 0.1 2.1 1 1 1 2 2 2 2 Cytochrome P450 BNR_2 PF13088.4 001293126.1_02224001_1 - 4.9e-35 121.0 0.0 6.6e-35 120.6 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.18 001293126.1_02224001_1 - 1.9e-06 26.9 1.6 1.7 8.8 0.0 4.0 3 0 0 3 3 3 3 BNR/Asp-box repeat BNR_3 PF13859.4 001293126.1_02224001_1 - 1.1e-05 24.8 0.0 1.5e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain Basic PF01586.14 001282891.1_37522001_1 - 1.9e-29 102.5 0.5 1.3e-28 99.9 0.0 2.2 2 0 0 2 2 2 1 Myogenic Basic domain HLH PF00010.24 001282891.1_37522001_1 - 2.1e-13 49.9 5.1 3.7e-13 49.1 5.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HicB PF05534.10 001282891.1_37522001_3 - 0.035 13.8 0.3 0.065 13.0 0.3 1.5 1 0 0 1 1 1 0 HicB family Insulin PF00049.16 001279503.1_37522001_1 - 1.3e-13 51.6 10.4 1.4e-06 29.1 3.3 2.9 2 1 1 3 3 3 2 Insulin/IGF/Relaxin family Hormone_recep PF00104.28 001279723.1_37523001_1 - 5.2e-23 81.6 0.0 8.4e-23 80.9 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor HSP20 PF00011.19 001279530.1_37522001_1 - 1.4e-24 86.1 0.2 2.2e-24 85.4 0.2 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Crystallin PF00525.16 001279530.1_37522001_1 - 1.6e-05 24.9 0.3 3.8e-05 23.7 0.3 1.6 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal YabP PF07873.9 001279530.1_37522001_1 - 0.0077 15.9 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 YabP family GvpO PF05800.9 001279530.1_37522001_1 - 0.046 13.6 0.1 0.11 12.3 0.1 1.6 1 1 1 2 2 2 0 Gas vesicle synthesis protein GvpO ABC2_membrane PF01061.22 001279483.1_37526001_3 - 1.5e-46 158.4 22.5 1.5e-46 158.4 22.5 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.25 001279483.1_37526001_3 - 2.6e-26 92.6 0.0 4.1e-26 92.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 001279483.1_37526001_3 - 2.5e-06 27.4 0.0 0.0074 16.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.17 001279483.1_37526001_3 - 1.8e-05 24.1 0.2 0.00026 20.4 0.2 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain DUF258 PF03193.14 001279483.1_37526001_3 - 0.001 18.9 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.4 001279483.1_37526001_3 - 0.0052 17.0 0.0 0.0082 16.4 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_13 PF13166.4 001279483.1_37526001_3 - 0.0089 14.6 0.0 0.067 11.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.4 001279483.1_37526001_3 - 0.016 14.8 0.1 0.035 13.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.21 001279483.1_37526001_3 - 0.027 14.4 0.1 0.047 13.6 0.1 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.4 001279483.1_37526001_3 - 0.04 14.3 0.0 0.066 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Glyco_hydro_56 PF01630.16 001279483.1_37526001_3 - 0.081 11.8 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Hyaluronidase AAA_23 PF13476.4 001279483.1_37526001_3 - 0.085 13.2 0.1 0.15 12.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain ArgK PF03308.14 001279483.1_37526001_3 - 0.21 10.4 0.0 0.35 9.7 0.0 1.2 1 0 0 1 1 1 0 ArgK protein ABC2_membrane_3 PF12698.5 001279483.1_37526001_3 - 1.4 7.8 21.2 1.4 7.8 19.4 1.7 1 1 1 2 2 2 0 ABC-2 family transporter protein Aldedh PF00171.20 001311328.1_37524001_2 - 2.3e-183 609.8 0.0 2.7e-183 609.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family TNFR_c6 PF00020.16 001311338.1_37524001_1 - 8.4e-17 61.2 62.3 3.3e-06 27.3 5.0 5.0 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region TMEM154 PF15102.4 001311338.1_37524001_1 - 0.41 10.4 4.6 0.1 12.4 0.4 2.2 2 0 0 2 2 2 0 TMEM154 protein family Pkinase PF00069.23 001319869.1_37526001_3 - 3.7e-71 239.5 0.0 5.1e-71 239.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001319869.1_37526001_3 - 1.2e-40 139.3 0.0 1.8e-40 138.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.3 001319869.1_37526001_3 - 5.7e-14 52.4 0.0 1.7e-13 50.9 0.0 1.8 1 0 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.4 001319869.1_37526001_3 - 4.1e-06 26.2 0.0 5.9e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 001319869.1_37526001_3 - 0.0004 19.9 0.2 0.00076 19.0 0.2 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.12 001319869.1_37526001_3 - 0.0019 17.5 0.1 0.0032 16.7 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001319869.1_37526001_3 - 0.018 14.9 0.0 0.038 13.8 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family YukC PF10140.7 001319869.1_37526001_3 - 0.11 11.2 0.0 0.18 10.5 0.0 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Toxin_29 PF08116.9 001311331.1_37525001_1 - 0.008 16.0 6.0 1.3 9.0 0.6 2.9 2 0 0 2 2 2 2 PhTx neurotoxin family TNFR_c6 PF00020.16 001311331.1_37525001_3 - 1.1e-12 48.0 18.2 8.6e-08 32.3 2.8 5.3 5 0 0 5 5 5 3 TNFR/NGFR cysteine-rich region Death PF00531.20 001311331.1_37525001_3 - 1.6e-06 28.0 0.3 0.00033 20.6 0.3 2.5 1 1 1 2 2 2 2 Death domain Cadherin PF00028.15 001111126.1_23526001_1 - 7.4e-84 276.2 0.0 4.4e-22 78.2 0.0 6.5 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001111126.1_23526001_1 - 3.3e-53 179.5 2.8 1e-52 177.8 2.8 1.9 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001111126.1_23526001_1 - 7.3e-33 112.1 0.0 3.8e-28 97.0 0.1 5.2 5 0 0 5 5 5 1 Cadherin-like Cadherin_3 PF16184.3 001111126.1_23526001_1 - 0.00066 19.5 0.0 4.4 7.2 0.0 4.4 5 0 0 5 5 5 1 Cadherin-like PepSY PF03413.17 001111126.1_23526001_1 - 0.0049 17.3 0.4 0.1 13.1 0.0 2.9 3 0 0 3 3 3 1 Peptidase propeptide and YPEB domain Cadherin_C_2 PF16492.3 001111126.1_23526001_1 - 0.0094 16.6 0.0 0.031 14.9 0.0 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_tail PF15974.3 001111126.1_23526001_3 - 4.6e-05 23.6 0.0 0.00015 22.0 0.0 1.9 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin PF00028.15 001111132.1_23526001_1 - 1.2e-79 262.7 0.0 3.7e-21 75.2 0.0 6.3 5 1 1 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001111132.1_23526001_1 - 3.6e-53 179.3 2.8 1e-52 177.8 2.8 1.9 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001111132.1_23526001_1 - 1.1e-33 114.8 0.6 3.8e-28 97.0 0.1 5.3 5 0 0 5 5 5 2 Cadherin-like Cadherin_3 PF16184.3 001111132.1_23526001_1 - 0.00016 21.5 0.0 2.8 7.9 0.0 4.4 5 0 0 5 5 5 2 Cadherin-like Cadherin_C_2 PF16492.3 001111132.1_23526001_1 - 0.0015 19.2 0.0 0.0049 17.5 0.0 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_tail PF15974.3 001111132.1_23526001_3 - 4.6e-05 23.6 0.0 0.00015 22.0 0.0 1.9 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin PF00028.15 001111137.1_23526001_1 - 4.6e-79 260.8 0.0 2.3e-18 66.3 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001111137.1_23526001_1 - 1e-52 177.8 2.8 1e-52 177.8 2.8 2.2 2 0 0 2 2 2 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001111137.1_23526001_1 - 1.2e-32 111.4 0.4 3.7e-28 97.0 0.1 5.2 5 0 0 5 5 5 1 Cadherin-like Cadherin_3 PF16184.3 001111137.1_23526001_1 - 0.00057 19.7 0.0 8.3 6.3 0.0 4.4 4 1 0 4 4 4 2 Cadherin-like Cadherin_C_2 PF16492.3 001111137.1_23526001_1 - 0.0096 16.6 0.0 0.031 14.9 0.0 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_tail PF15974.3 001111137.1_23526001_3 - 4.3e-05 23.7 0.0 0.00015 22.0 0.0 1.9 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region HLH PF00010.24 204566.1_23523001_1 - 9.8e-13 47.7 0.8 9.8e-13 47.7 0.8 1.6 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain 2OG-FeII_Oxy_2 PF13532.4 001031552.2_23525001_1 - 2.7e-35 122.3 0.0 4.2e-35 121.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TIR_2 PF13676.4 001311322.1_37524001_1 - 3.5e-12 46.4 0.0 5.6e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 TIR domain TIR PF01582.18 001311322.1_37524001_1 - 4e-12 46.1 0.0 9.6e-12 44.9 0.0 1.5 2 0 0 2 2 2 1 TIR domain Death PF00531.20 001311322.1_37524001_1 - 1.8e-10 40.7 0.0 4.5e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Death domain Basic PF01586.14 001279526.1_37524001_3 - 3e-30 105.1 0.0 7.8e-30 103.8 0.0 1.7 1 0 0 1 1 1 1 Myogenic Basic domain HLH PF00010.24 001279526.1_37524001_3 - 4e-12 45.8 4.7 6.9e-12 45.0 4.7 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF3080 PF11279.6 001279526.1_37524001_3 - 0.049 12.7 0.1 0.072 12.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3080) Thioredoxin_7 PF13899.4 001328230.1_02222001_1 - 4.5e-18 65.1 0.0 7.1e-18 64.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.18 001328230.1_02222001_1 - 8.2e-06 25.6 0.0 1.3e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.4 001328230.1_02222001_1 - 0.00052 20.3 0.0 0.00087 19.6 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredox_DsbH PF03190.13 001328230.1_02222001_1 - 0.013 15.4 0.0 0.017 14.9 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function, DUF255 AhpC-TSA PF00578.19 001328230.1_02222001_1 - 0.035 13.9 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_9 PF14595.4 001328230.1_02222001_1 - 0.059 13.0 0.0 0.097 12.3 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_8 PF13905.4 001328230.1_02222001_1 - 0.087 13.0 0.3 0.67 10.2 0.0 2.4 2 1 1 3 3 3 0 Thioredoxin-like BNR_2 PF13088.4 001311336.1_37523001_1 - 9.1e-34 116.9 0.0 2.8e-32 112.0 0.0 2.1 1 1 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.4 001311336.1_37523001_1 - 1.8e-06 27.3 0.0 2.4e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Kelch_1 PF01344.23 001030960.2_23528001_3 - 7.7e-89 291.0 21.4 4.1e-17 61.4 0.7 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 001030960.2_23528001_3 - 4.4e-49 163.1 8.6 6.3e-10 38.8 0.2 6.5 1 1 5 6 6 6 6 Kelch motif Kelch_2 PF07646.13 001030960.2_23528001_3 - 1.3e-38 129.4 6.8 1e-08 34.7 0.1 6.7 6 0 0 6 6 6 6 Kelch motif BACK PF07707.13 001030960.2_23528001_3 - 8.4e-34 115.6 1.4 8.4e-34 115.6 1.4 1.6 2 0 0 2 2 1 1 BTB And C-terminal Kelch BTB PF00651.29 001030960.2_23528001_3 - 1.5e-31 108.8 0.1 2.6e-31 108.0 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_4 PF13418.4 001030960.2_23528001_3 - 1.5e-25 88.8 3.4 5.2e-06 26.2 0.1 6.1 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.4 001030960.2_23528001_3 - 1.6e-24 85.5 9.5 4.9e-06 26.5 0.3 6.7 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.4 001030960.2_23528001_3 - 8.2e-08 31.9 15.6 0.055 13.3 0.1 6.4 6 0 0 6 6 6 2 Kelch motif DUF3342 PF11822.6 001030960.2_23528001_3 - 0.00016 21.6 0.3 0.00066 19.7 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) PQQ_3 PF13570.4 001030960.2_23528001_3 - 0.017 15.5 4.0 7.7 7.0 0.0 4.4 4 0 0 4 4 4 0 PQQ-like domain Glu_cyclase_2 PF05096.10 001030960.2_23528001_3 - 0.027 13.8 0.0 0.13 11.5 0.0 2.0 2 0 0 2 2 2 0 Glutamine cyclotransferase Peptidase_C13 PF01650.16 001031278.1_23525001_3 - 7.7e-43 146.7 0.0 1.1e-42 146.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family ArgoMid PF16487.3 001031278.1_23525001_3 - 0.017 15.2 0.1 0.043 13.9 0.1 1.6 1 0 0 1 1 1 0 Mid domain of argonaute Peptidase_C14 PF00656.20 001031278.1_23525001_3 - 0.093 12.5 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Caspase domain Thioredoxin PF00085.18 001006370.1_23525001_1 - 2.3e-96 316.5 1.3 3.2e-31 107.2 0.0 3.4 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.4 001006370.1_23525001_1 - 2.2e-26 92.8 10.8 5.3e-18 65.5 1.5 4.8 4 1 0 4 4 4 4 Thioredoxin-like domain Thioredoxin_8 PF13905.4 001006370.1_23525001_1 - 2e-17 63.1 3.1 0.003 17.7 0.0 6.4 4 2 2 6 6 6 3 Thioredoxin-like Thioredoxin_2 PF13098.4 001006370.1_23525001_1 - 3.7e-15 56.2 1.5 0.0031 17.8 0.1 4.5 3 1 0 3 3 3 3 Thioredoxin-like domain Calsequestrin PF01216.15 001006370.1_23525001_1 - 7e-15 54.8 2.9 2.6e-13 49.7 0.2 2.6 2 1 0 2 2 2 2 Calsequestrin OST3_OST6 PF04756.11 001006370.1_23525001_1 - 2e-14 53.5 0.1 4.5e-05 22.8 0.0 3.2 3 0 0 3 3 3 3 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.4 001006370.1_23525001_1 - 3e-12 46.4 0.1 0.036 14.1 0.0 4.4 5 0 0 5 5 5 3 Thioredoxin-like AhpC-TSA PF00578.19 001006370.1_23525001_1 - 2.1e-09 37.2 1.1 0.09 12.6 0.0 4.2 3 1 1 4 4 4 3 AhpC/TSA family Redoxin PF08534.8 001006370.1_23525001_1 - 1.1e-05 25.0 1.9 0.94 9.0 0.0 4.0 4 0 0 4 4 4 3 Redoxin TraF PF13728.4 001006370.1_23525001_1 - 1.6e-05 24.8 0.0 0.14 11.9 0.0 3.4 3 0 0 3 3 3 1 F plasmid transfer operon protein Thioredoxin_4 PF13462.4 001006370.1_23525001_1 - 1.8e-05 24.8 2.4 3.5 7.6 0.0 4.2 4 0 0 4 4 4 3 Thioredoxin HyaE PF07449.9 001006370.1_23525001_1 - 0.00099 18.9 0.0 8.6 6.2 0.0 3.6 3 0 0 3 3 3 1 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.4 001006370.1_23525001_1 - 0.0043 16.7 0.2 2.8 7.6 0.0 3.3 3 0 0 3 3 3 1 Thioredoxin DNA_pol_phi PF04931.11 001006370.1_23525001_1 - 0.87 7.5 5.9 1.3 6.9 5.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi WH2 PF02205.18 001012917.1_23529001_3 - 1e-10 41.0 0.7 3.4e-10 39.3 0.9 1.8 2 0 0 2 2 2 1 WH2 motif CAP_N PF01213.17 001012917.1_23529001_3 - 8.8e-05 22.0 3.0 8.8e-05 22.0 3.0 7.0 2 1 2 4 4 4 1 Adenylate cyclase associated (CAP) N terminal Metallophos PF00149.26 001079765.1_23523001_1 - 4.6e-36 125.1 0.2 5.8e-36 124.8 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Myotub-related PF06602.12 001031101.1_23529001_1 - 4.1e-129 430.3 0.0 5.3e-129 429.9 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.18 001031101.1_23529001_1 - 0.0044 16.7 0.0 0.0095 15.6 0.0 1.5 1 0 0 1 1 1 1 GRAM domain Hydrolase_6 PF13344.4 001031101.1_23529001_1 - 0.051 13.6 0.0 0.096 12.7 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DivIVA PF05103.11 001031101.1_23529001_1 - 0.1 12.5 0.8 0.17 11.9 0.8 1.3 1 0 0 1 1 1 0 DivIVA protein Peptidase_A22B PF04258.11 001012769.1_23529001_3 - 4.5e-79 265.8 18.9 1e-78 264.6 18.9 1.6 1 0 0 1 1 1 1 Signal peptide peptidase PA PF02225.20 001012769.1_23529001_3 - 1.5e-05 24.9 0.0 2.5e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 PA domain Presenilin PF01080.15 001012769.1_23529001_3 - 0.019 13.6 28.0 0.064 11.9 4.8 2.2 2 0 0 2 2 2 0 Presenilin NapE PF06796.9 001012769.1_23529001_3 - 0.058 12.8 0.3 0.25 10.7 0.3 2.2 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE MMPL PF03176.13 001012769.1_23529001_3 - 1.4 7.6 6.6 2.8 6.7 0.1 2.3 2 0 0 2 2 2 0 MMPL family DUF1180 PF06679.10 001001614.1_23523001_1 - 0.013 15.7 3.2 0.031 14.6 3.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) Trp_oprn_chp PF09534.8 001001614.1_23523001_1 - 1.5 8.5 9.7 0.75 9.4 1.0 2.1 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2070 PF09843.7 001001614.1_23523001_2 - 4.1 5.5 7.5 6 4.9 7.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Noc2 PF03715.11 001030876.1_23526001_2 - 2.9e-128 427.2 8.3 4.8e-128 426.5 8.3 1.3 1 0 0 1 1 1 1 Noc2p family zf-C4 PF00105.16 204702.1_23523001_3 - 2.8e-29 101.2 14.0 4.7e-29 100.5 14.0 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 204702.1_23523001_3 - 3.9e-19 68.9 0.9 9.3e-19 67.7 0.9 1.5 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Phosducin PF02114.14 001030812.1_23523001_2 - 2.4e-17 62.6 0.5 3.3e-17 62.2 0.5 1.2 1 0 0 1 1 1 1 Phosducin UPF0175 PF03683.11 001030812.1_23523001_2 - 0.0028 17.2 1.8 0.0053 16.3 0.6 2.1 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0175) Dynein_light PF01221.16 001006242.1_23523001_2 - 1.2e-26 92.7 0.2 1.9e-26 92.0 0.2 1.3 1 0 0 1 1 1 1 Dynein light chain type 1 DOR PF14839.4 001030946.1_23529001_2 - 5e-79 265.6 0.3 8.2e-79 264.9 0.3 1.3 1 0 0 1 1 1 1 DOR family AAA PF00004.27 001031286.1_23526001_3 - 2e-16 60.5 0.0 4.4e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Cdc6_C PF09079.9 001031286.1_23526001_3 - 7.9e-14 51.3 1.5 1.2e-13 50.7 0.2 2.0 2 0 0 2 2 2 1 CDC6, C terminal winged helix domain AAA_16 PF13191.4 001031286.1_23526001_3 - 1.8e-11 44.6 0.0 1.9e-10 41.3 0.0 2.7 2 2 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 001031286.1_23526001_3 - 2e-10 40.9 0.0 6.3e-10 39.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain BAH PF01426.16 001031286.1_23526001_3 - 6.2e-09 35.6 0.1 2.1e-08 33.9 0.1 1.9 1 0 0 1 1 1 1 BAH domain AAA_19 PF13245.4 001031286.1_23526001_3 - 0.00077 19.7 0.2 0.0026 18.0 0.2 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.4 001031286.1_23526001_3 - 0.0026 17.4 0.0 0.0052 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain TniB PF05621.9 001031286.1_23526001_3 - 0.0029 16.7 0.0 0.034 13.2 0.0 2.2 2 0 0 2 2 2 1 Bacterial TniB protein DUF2075 PF09848.7 001031286.1_23526001_3 - 0.013 14.6 0.0 0.028 13.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.10 001031286.1_23526001_3 - 0.035 13.9 0.1 0.11 12.3 0.1 1.8 1 1 0 1 1 1 0 NACHT domain RRM_1 PF00076.20 001031428.1_23525001_1 - 3.8e-36 122.6 0.2 2e-17 62.6 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001031428.1_23525001_1 - 4.1e-14 52.3 0.2 2.5e-07 30.6 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 001031428.1_23525001_1 - 9.9e-06 25.3 0.1 0.033 14.0 0.1 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.4 001031428.1_23525001_1 - 0.0023 18.1 0.0 1.5 8.9 0.0 2.9 2 1 1 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter CSD PF00313.20 001031428.1_23525001_1 - 0.14 11.9 1.4 2.9 7.7 0.1 2.4 2 0 0 2 2 2 0 'Cold-shock' DNA-binding domain PCNP PF15473.4 001006253.1_23525001_3 - 1.5e-66 223.8 12.9 1.9e-66 223.4 12.9 1.1 1 0 0 1 1 1 1 PEST, proteolytic signal-containing nuclear protein family SPATIAL PF15256.4 001006253.1_23525001_3 - 0.065 13.4 0.5 0.13 12.5 0.3 1.6 1 1 0 1 1 1 0 SPATIAL DUF3689 PF12463.6 001039317.1_23529001_1 - 6.4e-133 442.6 15.6 9.5e-133 442.1 15.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3689) TIP49 PF06068.11 001006138.1_23524001_3 - 6.9e-195 647.5 0.3 8.2e-195 647.2 0.3 1.0 1 0 0 1 1 1 1 TIP49 C-terminus RuvB_N PF05496.10 001006138.1_23524001_3 - 6.3e-13 48.4 1.7 4.9e-08 32.4 0.0 3.1 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA PF00004.27 001006138.1_23524001_3 - 1.8e-12 47.7 0.3 3.9e-08 33.7 0.0 3.0 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 001006138.1_23524001_3 - 3.4e-06 27.2 0.1 0.15 12.2 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.4 001006138.1_23524001_3 - 2.7e-05 24.5 0.0 0.0005 20.4 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.12 001006138.1_23524001_3 - 0.00012 22.0 0.1 0.0056 16.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.4 001006138.1_23524001_3 - 0.00027 20.4 0.0 0.0012 18.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.24 001006138.1_23524001_3 - 0.00041 20.0 0.1 0.27 10.8 0.1 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain Mg_chelatase PF01078.19 001006138.1_23524001_3 - 0.0015 17.8 0.1 0.051 12.8 0.1 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.4 001006138.1_23524001_3 - 0.0018 18.7 0.0 0.012 16.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.15 001006138.1_23524001_3 - 0.0023 17.6 0.0 0.0045 16.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.4 001006138.1_23524001_3 - 0.0024 18.1 1.5 0.057 13.6 1.5 2.3 1 1 0 1 1 1 1 AAA domain DnaB_C PF03796.13 001006138.1_23524001_3 - 0.0039 16.4 0.0 0.0073 15.5 0.0 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_28 PF13521.4 001006138.1_23524001_3 - 0.0041 17.3 0.1 0.0072 16.5 0.1 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.10 001006138.1_23524001_3 - 0.015 14.5 0.2 0.035 13.3 0.1 1.6 2 0 0 2 2 2 0 Zeta toxin PhoH PF02562.14 001006138.1_23524001_3 - 0.019 14.3 0.1 0.049 13.0 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein ResIII PF04851.13 001006138.1_23524001_3 - 0.019 14.8 0.0 0.48 10.3 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit NACHT PF05729.10 001006138.1_23524001_3 - 0.019 14.7 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.4 001006138.1_23524001_3 - 0.02 14.9 0.0 0.045 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.15 001006138.1_23524001_3 - 0.023 14.5 0.0 0.049 13.5 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.4 001006138.1_23524001_3 - 0.025 14.2 0.0 0.047 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.15 001006138.1_23524001_3 - 0.026 13.5 0.0 0.052 12.5 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_30 PF13604.4 001006138.1_23524001_3 - 0.068 12.8 0.1 1.1 8.9 0.1 2.2 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.7 001006138.1_23524001_3 - 0.1 11.7 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ATPase PF06745.11 001006138.1_23524001_3 - 0.13 11.5 1.8 0.28 10.4 0.0 2.3 3 0 0 3 3 3 0 KaiC UBA2_C PF16195.3 001030571.1_23526001_2 - 1e-24 86.9 11.3 1.8e-24 86.1 11.3 1.4 1 0 0 1 1 1 1 SUMO-activating enzyme subunit 2 C-terminus UAE_UbL PF14732.4 001030571.1_23526001_2 - 7.5e-23 80.9 1.0 7.5e-23 80.9 1.0 1.7 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain ThiF PF00899.19 001030571.1_23526001_3 - 9.6e-74 247.7 0.0 1.4e-73 247.1 0.0 1.1 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.7 001030571.1_23526001_3 - 7.3e-08 32.5 0.8 0.0045 16.8 0.2 2.2 1 1 0 2 2 2 2 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.4 001030571.1_23526001_3 - 0.0025 18.1 0.0 0.005 17.1 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Thyroglobulin_1 PF00086.16 204353.1_23524001_2 - 1.7e-19 69.1 0.7 4.6e-19 67.7 0.7 1.8 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 204353.1_23524001_2 - 1.5e-08 35.0 23.2 1.5e-08 35.0 23.2 3.5 3 0 0 3 3 3 1 Insulin-like growth factor binding protein THP2 PF09432.8 001030625.1_23523001_2 - 0.0041 17.0 4.1 0.0041 17.0 4.1 2.6 3 0 0 3 3 3 1 Tho complex subunit THP2 CotJB PF12652.5 001030625.1_23523001_2 - 0.05 13.7 0.6 0.15 12.2 0.6 1.8 1 0 0 1 1 1 0 CotJB protein CHDCT2 PF08074.9 001030625.1_23523001_2 - 0.075 13.1 7.7 0.15 12.1 7.7 1.5 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain AAA_31 PF13614.4 001030625.1_23523001_2 - 0.14 12.0 2.6 0.21 11.3 1.7 1.7 1 1 1 2 2 2 0 AAA domain Atg14 PF10186.7 001030625.1_23523001_2 - 0.29 10.0 13.1 0.52 9.2 13.1 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 SecD-TM1 PF13721.4 001030625.1_23523001_2 - 0.74 10.2 4.2 9.3 6.6 0.7 2.5 1 1 1 2 2 2 0 SecD export protein N-terminal TM region Leu_zip PF15294.4 001030625.1_23523001_2 - 1.2 8.5 25.9 0.032 13.6 18.6 1.9 2 0 0 2 2 2 0 Leucine zipper DUF724 PF05266.12 001030625.1_23523001_2 - 1.9 8.2 17.8 0.18 11.5 9.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF1664 PF07889.10 001030625.1_23523001_2 - 4.9 7.0 17.0 13 5.7 4.3 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) WD40 PF00400.30 001079747.1_23526001_2 - 1.8e-26 91.7 17.8 3e-05 24.5 0.2 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001079747.1_23526001_2 - 6.7e-18 64.6 1.3 1.9e-06 28.0 0.0 5.3 1 1 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001079747.1_23526001_2 - 3e-06 27.1 0.1 0.11 12.2 0.1 3.2 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.3 001079747.1_23526001_2 - 0.00065 19.0 0.0 0.62 9.2 0.0 2.6 3 0 0 3 3 3 2 WD40-like domain PQQ_2 PF13360.4 001079747.1_23526001_2 - 0.0028 17.1 0.1 0.046 13.2 0.0 2.2 2 0 0 2 2 2 1 PQQ-like domain Nup160 PF11715.6 001079747.1_23526001_2 - 0.044 12.3 0.1 0.48 8.8 0.0 2.2 2 0 0 2 2 2 0 Nucleoporin Nup120/160 PQQ PF01011.19 001079747.1_23526001_2 - 0.17 11.7 3.5 3.2 7.7 0.0 3.8 4 0 0 4 4 4 0 PQQ enzyme repeat Fibrinogen_C PF00147.16 001079486.1_23527001_1 - 1.5e-89 299.4 9.4 2.1e-89 299.0 9.4 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain FlaC_arch PF05377.9 001079486.1_23527001_1 - 0.0025 18.0 2.7 0.0044 17.2 0.6 2.2 2 0 0 2 2 2 1 Flagella accessory protein C (FlaC) SOGA PF11365.6 001079486.1_23527001_1 - 0.06 14.3 1.5 0.14 13.1 1.5 1.6 1 0 0 1 1 1 0 Protein SOGA Med9 PF07544.11 001079486.1_23527001_1 - 0.092 12.7 5.6 0.41 10.6 0.3 2.5 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF2365 PF10157.7 001079486.1_23527001_1 - 0.18 11.9 1.6 0.33 11.0 1.6 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2365) BLOC1_2 PF10046.7 001079486.1_23527001_1 - 0.36 11.0 4.4 8.1 6.7 2.0 2.4 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.10 001079486.1_23527001_1 - 1.5 8.7 7.9 0.26 11.1 2.6 2.1 2 0 0 2 2 2 0 Laminin Domain II YscO PF07321.10 001079486.1_23527001_1 - 3.6 7.4 6.1 3.2 7.6 1.1 2.1 2 0 0 2 2 2 0 Type III secretion protein YscO XhlA PF10779.7 001079486.1_23527001_1 - 4.7 7.3 5.7 0.52 10.4 0.6 1.9 2 0 0 2 2 2 0 Haemolysin XhlA Prefoldin PF02996.15 001079486.1_23527001_1 - 5.5 6.8 6.3 18 5.1 0.6 2.5 2 0 0 2 2 2 0 Prefoldin subunit PRKG1_interact PF15898.3 001079486.1_23527001_1 - 5.5 7.8 6.8 16 6.3 6.8 1.8 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Patatin PF01734.20 001130740.1_23522001_1 - 6.1e-17 62.3 0.2 1e-15 58.3 0.2 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase ORC3_N PF07034.9 001031082.1_23525001_1 - 4e-125 417.2 4.6 4e-125 417.2 4.6 1.8 2 0 0 2 2 2 1 Origin recognition complex (ORC) subunit 3 N-terminus PHD_like PF12910.5 001031082.1_23525001_1 - 0.45 10.4 0.0 0.45 10.4 0.0 2.6 4 0 0 4 4 4 0 Antitoxin of toxin-antitoxin, RelE / RelB, TA system UDG PF03167.17 204750.1_23527001_3 - 1.2e-17 64.2 0.0 1.9e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily GAGA_bind PF06217.10 204750.1_23527001_3 - 0.3 11.2 4.3 0.5 10.5 4.3 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family ORC5_C PF14630.4 001030729.1_23527001_3 - 3.5e-65 220.3 0.2 5e-65 219.7 0.2 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.4 001030729.1_23527001_3 - 6.3e-15 55.8 0.1 1e-14 55.2 0.1 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 001030729.1_23527001_3 - 2.9e-08 33.9 0.3 1e-07 32.2 0.1 1.8 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.16 001030729.1_23527001_3 - 0.0061 16.4 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea Kinesin PF00225.21 001030729.1_23527001_3 - 0.012 14.4 0.0 0.019 13.7 0.0 1.2 1 0 0 1 1 1 0 Kinesin motor domain Microtub_bd PF16796.3 001030729.1_23527001_3 - 0.042 13.7 0.0 0.081 12.7 0.0 1.3 1 0 0 1 1 1 0 Microtubule binding AAA PF00004.27 001030729.1_23527001_3 - 0.064 13.5 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.4 001030729.1_23527001_3 - 0.065 12.8 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.12 001030729.1_23527001_3 - 0.087 11.8 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase RRM_5 PF13893.4 001030935.1_23529001_2 - 1.4e-57 192.6 0.4 3.2e-40 136.5 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 001030935.1_23529001_2 - 3.8e-33 113.0 1.0 4.7e-10 39.0 0.0 4.7 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001030935.1_23529001_2 - 5.4e-09 35.7 0.2 0.36 10.6 0.0 4.3 4 0 0 4 4 4 4 Occluded RNA-recognition motif IGF2_C PF08365.9 001279643.1_37522001_1 - 6e-29 99.7 5.0 6e-29 99.7 5.0 1.8 2 0 0 2 2 2 1 Insulin-like growth factor II E-peptide Insulin PF00049.16 001279643.1_37522001_1 - 7.6e-15 55.5 5.0 7.8e-07 29.9 2.6 2.8 1 1 1 2 2 2 2 Insulin/IGF/Relaxin family VPS28 PF03997.10 001279643.1_37522001_1 - 0.068 12.7 0.2 0.12 11.9 0.2 1.4 1 0 0 1 1 1 0 VPS28 protein 2-Hacid_dh_C PF02826.17 001012890.1_23525001_1 - 9.6e-57 191.1 0.0 1.3e-56 190.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 001012890.1_23525001_1 - 3e-28 98.0 0.0 3.8e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 001012890.1_23525001_1 - 4.7e-05 23.5 0.0 8.1e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Cellsynth_D PF03500.11 001012890.1_23525001_1 - 0.051 13.3 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Cellulose synthase subunit D XdhC_C PF13478.4 001012890.1_23525001_1 - 0.15 12.4 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain Thg1 PF04446.10 001030616.1_23524001_1 - 2.7e-51 172.7 0.6 4.1e-51 172.1 0.6 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.4 001030616.1_23524001_1 - 3.2e-49 166.0 0.2 5.2e-49 165.3 0.2 1.3 1 0 0 1 1 1 1 Thg1 C terminal domain G-patch PF01585.21 001031046.1_23529001_1 - 2.8e-16 59.0 1.5 4.9e-16 58.2 1.5 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 001031046.1_23529001_1 - 1.5e-08 34.5 0.4 3.5e-08 33.3 0.4 1.6 1 0 0 1 1 1 1 G-patch domain Siva PF05458.10 001277535.1_23522001_2 - 6.4e-63 211.4 12.7 7.6e-63 211.2 12.7 1.1 1 0 0 1 1 1 1 Cd27 binding protein (Siva) B3_4 PF03483.15 001006543.1_23524001_1 - 3.6e-29 101.5 0.0 6.1e-29 100.8 0.0 1.4 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.13 001006543.1_23524001_1 - 7e-16 58.1 0.0 3.3e-13 49.6 0.0 3.4 3 0 0 3 3 3 2 tRNA synthetase B5 domain zf-DHHC PF01529.18 001012819.1_23529001_2 - 3e-31 108.2 9.0 3e-31 108.2 9.0 2.6 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ost4 PF10215.7 001198884.1_23521001_1 - 1.1e-15 57.0 1.7 1.4e-15 56.7 1.7 1.1 1 0 0 1 1 1 1 Oligosaccaryltransferase Yip1 PF04893.15 001277610.1_23523001_1 - 7.4e-20 71.2 13.4 1.1e-19 70.7 13.4 1.3 1 0 0 1 1 1 1 Yip1 domain V-set PF07686.15 001031372.2_23528001_1 - 4.3e-18 65.3 0.3 1.6e-13 50.6 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin V-set domain C1-set PF07654.13 001031372.2_23528001_1 - 2.4e-15 56.6 0.5 6.5e-15 55.2 0.2 1.9 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001031372.2_23528001_1 - 4.7e-15 55.8 1.3 2.1e-07 31.3 0.7 2.6 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001031372.2_23528001_1 - 9.4e-11 41.6 0.6 2.9e-05 24.0 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001031372.2_23528001_1 - 5.9e-10 39.0 0.0 0.00015 21.6 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 001031372.2_23528001_1 - 4.3e-06 26.8 0.2 0.029 14.6 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001031372.2_23528001_1 - 0.026 14.5 0.1 0.075 13.0 0.1 1.8 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 001031372.2_23528001_1 - 0.029 14.3 0.0 0.094 12.6 0.0 1.9 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain IL15 PF02372.13 001024835.1_23521001_1 - 5.4e-11 42.5 0.6 7.3e-11 42.1 0.6 1.1 1 0 0 1 1 1 1 Interleukin 15 zf-C2H2_jaz PF12171.6 001031465.1_23523001_3 - 5.9e-07 29.5 1.5 1.7e-06 28.1 1.5 1.9 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding DUF1777 PF08648.10 001031465.1_23523001_3 - 8.6e-06 26.0 16.9 1.6e-05 25.1 16.9 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1777) zf-met PF12874.5 001031465.1_23523001_3 - 1.4e-05 25.1 0.9 5.1e-05 23.4 0.9 2.0 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-U1 PF06220.10 001031465.1_23523001_3 - 0.00043 19.8 1.0 0.00075 19.1 1.0 1.4 1 0 0 1 1 1 1 U1 zinc finger zf-C2H2 PF00096.24 001031465.1_23523001_3 - 0.15 12.4 0.9 0.66 10.4 0.9 2.2 1 0 0 1 1 1 0 Zinc finger, C2H2 type Vma12 PF11712.6 001031465.1_23523001_3 - 3.6 7.5 9.8 16 5.4 3.2 3.1 3 0 0 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase SIMPL PF04402.12 001278022.1_23522001_1 - 3e-21 76.7 0.0 3.5e-21 76.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) Vps35 PF03635.15 001005842.1_23527001_2 - 8.3e-300 996.4 13.2 9.7e-300 996.2 13.2 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 FerA PF08165.9 001005842.1_23527001_2 - 0.035 13.9 0.2 0.15 11.9 0.2 2.1 1 0 0 1 1 1 0 FerA (NUC095) domain IMD PF08397.9 001277529.1_23525001_2 - 5.6e-63 212.1 4.7 7.1e-63 211.8 4.7 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain SH3_9 PF14604.4 001277529.1_23525001_2 - 1.6e-10 40.6 0.0 2.9e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001277529.1_23525001_2 - 1.9e-07 30.5 0.0 3.3e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001277529.1_23525001_2 - 5.2e-06 25.8 0.0 9.5e-06 25.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain BAR_3 PF16746.3 001277529.1_23525001_2 - 0.00079 19.0 10.1 0.0041 16.7 10.0 1.8 1 1 0 1 1 1 1 BAR domain of APPL family Rhabdo_M1 PF03342.11 001277529.1_23525001_2 - 0.018 14.3 0.7 0.035 13.3 0.7 1.4 1 0 0 1 1 1 0 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) T2SSF PF00482.21 001277529.1_23525001_2 - 0.11 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F DUF1664 PF07889.10 001277529.1_23525001_2 - 0.66 9.8 2.8 1.5 8.6 2.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) OrfB_IS605 PF01385.17 001277529.1_23525001_2 - 1.6 8.9 6.1 0.34 11.0 0.1 2.3 1 1 1 2 2 2 0 Probable transposase LRR_4 PF12799.5 001277428.1_23523001_2 - 9.6e-35 117.8 42.9 1.2e-08 35.0 3.0 7.2 1 1 6 9 9 9 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001277428.1_23523001_2 - 8.3e-28 96.9 23.8 2.9e-11 43.1 0.7 4.1 1 1 3 4 4 4 4 Leucine-rich repeat LRR_8 PF13855.4 001277428.1_23523001_2 - 1.7e-20 72.4 39.5 9.5e-07 28.4 8.4 6.3 2 2 1 5 5 5 5 Leucine rich repeat LRR_1 PF00560.31 001277428.1_23523001_2 - 0.0058 16.8 25.7 0.7 10.5 0.2 8.5 7 2 1 8 8 8 1 Leucine Rich Repeat LRR_6 PF13516.4 001277428.1_23523001_2 - 1.6 8.9 28.1 4.8 7.4 0.0 7.5 8 1 1 9 9 9 0 Leucine Rich repeat Ribosomal_L50 PF10501.7 001277428.1_23523001_2 - 3.8 7.6 8.6 4.5 7.4 0.1 3.6 2 1 2 5 5 5 0 Ribosomal subunit 39S LRR_4 PF12799.5 001277562.1_23522001_3 - 0.13 12.6 3.2 0.27 11.6 0.2 2.8 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) Yip1 PF04893.15 001277607.1_23523001_3 - 2.1e-19 69.8 14.2 3e-19 69.3 14.2 1.2 1 0 0 1 1 1 1 Yip1 domain SYF2 PF08231.10 001257294.1_23523001_1 - 9.8e-57 191.7 11.6 9.8e-57 191.7 11.6 1.8 2 1 0 2 2 2 1 SYF2 splicing factor FUSC-like PF12805.5 001257294.1_23523001_1 - 0.015 14.2 0.2 0.025 13.5 0.2 1.3 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS rve_3 PF13683.4 001257294.1_23523001_1 - 0.048 13.3 0.5 0.75 9.5 0.0 2.7 3 0 0 3 3 3 0 Integrase core domain GrpE PF01025.17 001006458.1_23524001_1 - 4.7e-45 153.1 3.0 6.2e-45 152.7 3.0 1.1 1 0 0 1 1 1 1 GrpE Cpn60_TCP1 PF00118.22 001006458.1_23524001_1 - 0.04 12.4 1.0 0.056 11.9 1.0 1.1 1 0 0 1 1 1 0 TCP-1/cpn60 chaperonin family LOH1CR12 PF10158.7 001006458.1_23524001_1 - 0.051 13.5 0.6 0.096 12.6 0.6 1.4 1 0 0 1 1 1 0 Tumour suppressor protein MetJ PF01340.18 001006458.1_23524001_1 - 0.058 13.2 0.2 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 Met Apo-repressor, MetJ Exonuc_VII_L PF02601.13 001006458.1_23524001_1 - 0.12 11.7 0.8 0.18 11.2 0.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Bap31 PF05529.10 001006458.1_23524001_1 - 0.14 11.6 6.4 0.24 10.8 6.4 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like DUF2205 PF10224.7 001006458.1_23524001_1 - 1.5 8.7 6.0 0.42 10.5 3.0 1.6 2 0 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) DUF3391 PF11871.6 001006458.1_23524001_1 - 1.8 9.0 4.9 2.9 8.3 4.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) DUF4407 PF14362.4 001006458.1_23524001_1 - 5.6 6.1 6.4 8.8 5.4 6.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NOT2_3_5 PF04153.16 001012808.1_23526001_3 - 1.3e-30 106.0 0.2 2.3e-30 105.2 0.2 1.4 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family MGTL PF17059.3 001012607.2_23525001_1 - 1.3 8.8 4.5 7.4 6.4 1.1 3.0 2 0 0 2 2 2 0 MgtA leader peptide Vps5 PF09325.8 001012607.2_23525001_3 - 5.8e-89 297.5 20.6 9.9e-89 296.8 20.6 1.4 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.22 001012607.2_23525001_3 - 7.5e-30 103.1 0.3 1.6e-28 98.8 0.1 2.4 2 0 0 2 2 2 1 PX domain Sorting_nexin PF03700.11 001012607.2_23525001_3 - 3.9e-24 85.5 14.2 9e-24 84.3 14.2 1.6 1 0 0 1 1 1 1 Sorting nexin, N-terminal domain BAR_3_WASP_bdg PF10456.7 001012607.2_23525001_3 - 2.9e-05 23.5 8.4 0.0029 17.0 8.4 2.5 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein FAM92 PF06730.9 001012607.2_23525001_3 - 3.8e-05 23.1 8.8 8.6e-05 21.9 8.8 1.5 1 0 0 1 1 1 1 FAM92 protein GrpE PF01025.17 001012607.2_23525001_3 - 0.0081 15.7 8.2 0.0081 15.7 8.2 2.5 2 0 0 2 2 2 1 GrpE Spc7 PF08317.9 001012607.2_23525001_3 - 0.15 10.8 22.2 0.35 9.6 5.5 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF4618 PF15397.4 001012607.2_23525001_3 - 0.28 10.4 14.8 0.099 11.9 0.7 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) DUF3138 PF11336.6 001012607.2_23525001_3 - 0.3 9.5 5.1 0.44 9.0 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) BAR_3 PF16746.3 001012607.2_23525001_3 - 1.1 8.7 16.6 5.1 6.6 9.6 2.3 1 1 1 2 2 2 0 BAR domain of APPL family Tropomyosin PF00261.18 001012607.2_23525001_3 - 1.7 7.8 18.9 0.024 13.9 5.7 2.3 2 0 0 2 2 2 0 Tropomyosin BLOC1_2 PF10046.7 001012607.2_23525001_3 - 2.1 8.6 15.1 0.33 11.2 1.4 3.5 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF342 PF03961.11 001012607.2_23525001_3 - 3.1 6.2 10.5 3.7 5.9 3.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF342) Dynamin_N PF00350.21 001012607.2_23525001_3 - 3.6 7.5 6.7 2 8.3 3.0 2.2 2 0 0 2 2 2 0 Dynamin family HR1 PF02185.14 001012607.2_23525001_3 - 4.1 7.5 13.8 1.2 9.2 0.6 3.4 3 0 0 3 3 3 0 Hr1 repeat Arfaptin PF06456.11 001012607.2_23525001_3 - 4.4 6.7 13.9 38 3.6 13.9 2.1 1 1 0 1 1 1 0 Arfaptin-like domain DUF2203 PF09969.7 001012607.2_23525001_3 - 5.4 7.6 11.1 8.8 6.9 2.1 3.0 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Exonuc_VII_L PF02601.13 001012607.2_23525001_3 - 8.4 5.7 20.0 1.5 8.1 7.0 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit Rab_eff_C PF04698.10 001278029.1_23524001_3 - 0.015 13.5 8.1 0.021 13.0 8.1 1.1 1 0 0 1 1 1 0 Rab effector MyRIP/melanophilin C-terminus DUF4710 PF15828.3 001278029.1_23524001_3 - 3.6 7.6 8.5 12 6.0 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) Lipase_3 PF01764.23 001030643.2_23527001_3 - 1.3e-15 57.4 0.0 2.1e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) AXE1 PF05448.10 001030643.2_23527001_3 - 0.13 10.8 0.0 0.2 10.2 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) BLOC1_2 PF10046.7 001277352.1_23523001_2 - 2.9e-34 117.1 8.9 3.8e-34 116.7 8.9 1.2 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 ParB PF08775.8 001277352.1_23523001_2 - 0.045 14.1 1.9 0.069 13.5 1.9 1.3 1 0 0 1 1 1 0 ParB family XhlA PF10779.7 001277352.1_23523001_2 - 2.4 8.3 7.5 3.7 7.7 0.3 2.9 3 0 0 3 3 3 0 Haemolysin XhlA CENP-Q PF13094.4 001277352.1_23523001_2 - 3.8 7.5 6.9 1.3 9.0 3.9 1.6 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Sec1 PF00995.21 001079734.2_23526001_1 - 3.1e-114 383.1 6.0 4e-114 382.7 6.0 1.0 1 0 0 1 1 1 1 Sec1 family UME PF08064.11 001079734.2_23526001_1 - 0.25 11.2 1.4 0.41 10.5 0.4 1.9 2 0 0 2 2 2 0 UME (NUC010) domain Spore_III_AF PF09581.8 001079734.2_23526001_1 - 7.2 6.5 8.0 3.6 7.4 2.7 2.6 2 1 0 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) Sec1 PF00995.21 001079734.2_23526001_2 - 0.00017 20.8 0.2 0.00022 20.4 0.2 1.1 1 0 0 1 1 1 1 Sec1 family HLH PF00010.24 204504.2_23529001_2 - 5.6e-13 48.5 0.4 1.1e-12 47.5 0.4 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Lectin_C PF00059.19 204666.1_23525001_1 - 5.1e-16 59.2 0.1 8.3e-16 58.5 0.1 1.4 1 0 0 1 1 1 1 Lectin C-type domain Chordopox_A33R PF05966.10 204666.1_23525001_1 - 0.012 14.8 0.1 0.021 14.0 0.1 1.3 1 0 0 1 1 1 0 Chordopoxvirus A33R protein DUF333 PF03891.13 204666.1_23525001_1 - 0.083 12.9 0.6 4.7 7.3 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF333) IL17 PF06083.9 045037.1_23521120_1 - 2.1e-22 79.2 0.7 2.1e-22 79.2 0.7 1.7 2 0 0 2 2 2 1 Interleukin-17 Thioredoxin_6 PF13848.4 001321606.1_23529001_1 - 3.9e-26 92.0 0.1 3.1e-24 85.8 0.4 2.2 1 1 1 2 2 2 1 Thioredoxin-like domain Thioredoxin PF00085.18 001321606.1_23529001_1 - 3.6e-25 87.8 0.0 1.3e-24 86.0 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.4 001321606.1_23529001_1 - 0.0036 17.6 0.0 0.018 15.3 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.4 001321606.1_23529001_1 - 0.035 14.1 0.0 0.079 13.0 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like ATP_synth_reg PF14960.4 001031173.2_23526001_2 - 0.0053 16.1 0.3 0.011 15.1 0.3 1.4 1 0 0 1 1 1 1 ATP synthase regulation Sec20 PF03908.11 001031173.2_23526001_2 - 0.093 12.5 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 Sec20 ATP-synt_E PF05680.10 001097534.2_23521001_1 - 2.6e-18 66.0 0.2 3.5e-18 65.6 0.2 1.2 1 0 0 1 1 1 1 ATP synthase E chain DUF1043 PF06295.10 001097534.2_23521001_1 - 0.025 14.5 0.0 0.036 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) EMI PF07546.11 001305681.1_23523001_2 - 8.3e-22 77.6 10.5 3.1e-21 75.8 10.5 2.0 1 0 0 1 1 1 1 EMI domain FXa_inhibition PF14670.4 001305681.1_23523001_2 - 3.2e-10 40.0 5.4 3.2e-10 40.0 5.4 3.6 2 1 1 3 3 3 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 001305681.1_23523001_2 - 2.4e-09 37.1 6.1 2.4e-09 37.1 6.1 3.0 2 1 0 2 2 2 1 Calcium-binding EGF domain cEGF PF12662.5 001305681.1_23523001_2 - 1.6e-06 27.8 13.0 4.4e-06 26.4 0.2 3.6 3 0 0 3 3 3 2 Complement Clr-like EGF-like EGF_2 PF07974.11 001305681.1_23523001_2 - 0.00051 20.2 12.4 0.00051 20.2 12.4 3.2 3 0 0 3 3 3 1 EGF-like domain EGF PF00008.25 001305681.1_23523001_2 - 0.0018 18.4 25.2 0.072 13.3 10.2 3.4 3 0 0 3 3 3 2 EGF-like domain EGF_3 PF12947.5 001305681.1_23523001_2 - 0.0031 17.5 3.2 0.0031 17.5 3.2 3.0 3 0 0 3 3 3 1 EGF domain hEGF PF12661.5 001305681.1_23523001_2 - 0.019 15.5 9.9 0.019 15.5 9.9 3.8 4 0 0 4 4 4 0 Human growth factor-like EGF bZIP_2 PF07716.13 001305681.1_23523001_2 - 0.55 10.2 3.7 10 6.1 1.5 2.3 2 0 0 2 2 2 0 Basic region leucine zipper Cnd1 PF12717.5 001080862.2_23529001_1 - 7.7e-52 175.4 9.4 6.9e-50 169.1 0.1 5.2 6 1 1 7 7 7 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.5 001080862.2_23529001_1 - 9.8e-37 126.2 0.1 3.2e-36 124.5 0.1 2.0 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.20 001080862.2_23529001_1 - 1.4e-06 27.9 8.9 1.1 9.6 0.1 7.9 8 0 0 8 8 8 1 HEAT repeat Adaptin_N PF01602.18 001080862.2_23529001_1 - 1.5e-06 26.9 8.9 0.00038 19.0 0.0 5.2 3 2 2 5 5 5 2 Adaptin N terminal region HEAT_2 PF13646.4 001080862.2_23529001_1 - 6.9e-05 23.0 4.1 0.073 13.3 0.0 6.2 6 1 1 7 7 7 1 HEAT repeats Cnd3 PF12719.5 001080862.2_23529001_1 - 0.0015 17.7 1.7 0.0069 15.5 0.0 2.7 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT_EZ PF13513.4 001080862.2_23529001_1 - 0.0057 17.0 0.2 27 5.2 0.0 4.6 3 0 0 3 3 3 0 HEAT-like repeat zf-RanBP PF00641.16 001039267.2_23525001_2 - 8.4e-13 47.3 7.4 1.3e-12 46.7 7.4 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_1 PF00076.20 001039267.2_23525001_2 - 3.3e-10 39.5 0.0 1.2e-09 37.7 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kazal_2 PF07648.13 204638.2_23529001_3 - 2.1e-12 46.9 4.9 6.4e-12 45.3 4.9 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain FOLN PF09289.8 204638.2_23529001_3 - 1.6e-06 28.0 1.9 5.9e-06 26.2 1.9 2.1 1 0 0 1 1 1 1 Follistatin/Osteonectin-like EGF domain Kazal_1 PF00050.19 204638.2_23529001_3 - 1.2e-05 25.0 9.6 3.1e-05 23.8 9.6 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain EF-hand_7 PF13499.4 204638.2_23529001_3 - 0.022 15.1 2.9 0.036 14.4 0.6 2.4 2 0 0 2 2 2 0 EF-hand domain pair Hormone_3 PF00159.16 204638.2_23529001_3 - 0.088 12.8 0.1 0.21 11.6 0.1 1.6 1 0 0 1 1 1 0 Pancreatic hormone peptide EF-hand_6 PF13405.4 204638.2_23529001_3 - 0.1 12.5 0.2 12 6.0 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain zf-4CXXC_R1 PF10497.7 001305283.1_23525001_2 - 1.2e-37 128.0 8.7 2.5e-37 127.0 8.7 1.6 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Endonuclease_7 PF02945.13 001305283.1_23525001_2 - 4.1 7.3 11.9 1.6 8.5 4.8 2.4 1 1 1 2 2 2 0 Recombination endonuclease VII LRR_4 PF12799.5 001199681.1_23529001_3 - 1.1e-10 41.4 8.3 0.00021 21.4 6.2 3.0 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001199681.1_23529001_3 - 3.5e-05 23.3 2.0 0.0037 16.6 0.1 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.4 001199681.1_23529001_3 - 9.2e-05 22.0 7.5 0.17 11.6 3.9 2.8 2 1 0 2 2 2 2 Leucine rich repeat Thioredoxin_6 PF13848.4 001321607.1_23529001_3 - 3.9e-26 92.0 0.1 3.1e-24 85.8 0.4 2.2 1 1 1 2 2 2 1 Thioredoxin-like domain Thioredoxin PF00085.18 001321607.1_23529001_3 - 3.6e-25 87.8 0.0 1.3e-24 86.0 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.4 001321607.1_23529001_3 - 0.0036 17.6 0.0 0.018 15.3 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.4 001321607.1_23529001_3 - 0.035 14.1 0.0 0.078 13.0 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like Tcp11 PF05794.11 001199407.1_23529001_2 - 5.9e-105 351.7 0.0 9e-105 351.1 0.0 1.3 1 0 0 1 1 1 1 T-complex protein 11 WD40 PF00400.30 001164395.1_23523001_3 - 7.9e-26 89.7 1.6 1.9e-06 28.4 2.0 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001164395.1_23523001_3 - 1.6e-12 47.4 0.0 0.006 16.7 0.0 5.1 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001164395.1_23523001_3 - 0.003 16.5 0.4 1 8.1 0.0 3.0 3 0 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ISN1 PF06437.9 001164395.1_23523001_3 - 0.0072 15.2 0.1 1.1 7.9 0.0 2.1 2 0 0 2 2 2 2 IMP-specific 5'-nucleotidase Nup160 PF11715.6 001164395.1_23523001_3 - 0.023 13.2 0.2 2 6.8 0.1 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Ank_2 PF12796.5 001293113.1_02227001_1 - 3.1e-82 271.1 16.4 8.3e-13 48.6 0.1 7.9 3 2 4 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001293113.1_02227001_1 - 8.9e-65 214.2 21.5 9.5e-09 35.5 0.1 11.4 5 3 8 14 14 14 11 Ankyrin repeats (many copies) Ank_3 PF13606.4 001293113.1_02227001_1 - 3e-61 196.0 14.8 9e-05 22.5 0.0 15.8 15 0 0 15 15 15 11 Ankyrin repeat Ank PF00023.28 001293113.1_02227001_1 - 5.5e-58 190.9 19.6 1.3e-06 28.5 0.0 15.4 15 0 0 15 15 15 12 Ankyrin repeat Ank_5 PF13857.4 001293113.1_02227001_1 - 3.2e-54 179.9 12.7 1.6e-07 31.4 0.0 11.7 5 4 6 11 11 11 10 Ankyrin repeats (many copies) Ion_trans PF00520.29 001293113.1_02227001_1 - 4.3e-14 52.2 22.9 7.6e-14 51.4 22.9 1.3 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.10 001293113.1_02227001_1 - 0.00028 19.5 22.6 0.00065 18.4 12.4 2.2 1 1 1 2 2 2 2 Polycystin cation channel DUF1843 PF08898.8 001293113.1_02227001_1 - 0.14 12.6 0.5 6.3 7.3 0.1 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) zf-4CXXC_R1 PF10497.7 001030982.2_23525001_3 - 1.4e-37 127.8 8.7 2.7e-37 126.8 8.7 1.5 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Endonuclease_7 PF02945.13 001030982.2_23525001_3 - 4.5 7.1 11.9 1.9 8.4 4.9 2.4 1 1 1 2 2 2 0 Recombination endonuclease VII DUF3585 PF12130.6 001201448.1_23529001_1 - 4.7e-46 156.2 16.5 6.9e-46 155.6 16.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3585) CH PF00307.29 001201448.1_23529001_1 - 3.8e-23 81.6 0.0 6.4e-23 80.9 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001201448.1_23529001_1 - 7.2e-09 35.2 0.0 1.3e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain LIM PF00412.20 001201448.1_23529001_1 - 2e-06 27.8 6.9 2e-06 27.8 6.9 2.1 2 0 0 2 2 2 1 LIM domain Roughex PF06020.9 001201448.1_23529001_1 - 0.009 15.0 5.8 0.018 14.0 5.8 1.4 1 0 0 1 1 1 1 Drosophila roughex protein CH_2 PF06294.9 001201448.1_23529001_1 - 0.18 11.8 0.0 0.42 10.6 0.0 1.5 1 0 0 1 1 1 0 CH-like domain in sperm protein G-patch PF01585.21 001277662.1_23523001_1 - 1.9e-14 53.1 1.2 3.5e-14 52.3 1.2 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 001277662.1_23523001_1 - 3.7e-06 26.8 0.4 3.7e-06 26.8 0.4 2.4 2 0 0 2 2 2 1 G-patch domain Rpp20 PF12328.6 001277662.1_23523001_1 - 3.6 7.4 9.3 0.13 12.1 0.7 2.2 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P DUF4187 PF13821.4 001277662.1_23523001_3 - 0.0096 15.5 0.3 0.03 13.9 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) RRM_1 PF00076.20 131063.1_23526120_1 - 2.7e-17 62.2 0.1 7e-17 60.9 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 131063.1_23526120_1 - 0.0044 17.0 0.0 0.0086 16.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif FA_desaturase PF00487.22 001160428.2_23525001_2 - 3.6e-34 118.6 26.5 3.7e-34 118.6 23.2 2.0 1 1 1 2 2 2 2 Fatty acid desaturase Cyt-b5 PF00173.26 001160428.2_23525001_2 - 6.7e-22 77.3 0.0 1.2e-21 76.5 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain CUB PF00431.18 001037837.2_23524001_1 - 9.1e-37 125.6 0.1 1.5e-36 124.9 0.1 1.4 1 0 0 1 1 1 1 CUB domain Xlink PF00193.15 001037837.2_23524001_1 - 1.9e-29 101.7 0.4 4.8e-29 100.5 0.3 1.7 2 0 0 2 2 2 1 Extracellular link domain Fez1 PF06818.13 001256151.1_23527001_1 - 0.0012 19.2 6.2 0.0029 17.9 6.2 1.6 1 0 0 1 1 1 1 Fez1 SPATA24 PF15175.4 001256151.1_23527001_1 - 0.13 12.0 12.2 0.31 10.8 12.2 1.5 1 0 0 1 1 1 0 Spermatogenesis-associated protein 24 HMMR_N PF15905.3 001256151.1_23527001_1 - 0.42 9.9 14.7 0.8 9.0 14.7 1.4 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal PKcGMP_CC PF16808.3 001256151.1_23527001_1 - 0.43 10.3 8.2 0.23 11.2 0.4 3.0 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF641 PF04859.10 001256151.1_23527001_1 - 1 9.6 11.4 3.7 7.8 4.3 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) ATG16 PF08614.9 001256151.1_23527001_1 - 1.7 8.6 16.2 0.31 11.1 11.7 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF342 PF03961.11 001256151.1_23527001_1 - 2.7 6.4 5.0 4.1 5.8 5.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Exonuc_VII_L PF02601.13 001256151.1_23527001_1 - 4.7 6.5 8.8 3.9 6.8 6.8 1.8 2 0 0 2 2 2 0 Exonuclease VII, large subunit ANF_receptor PF01094.26 001080610.1_16126001_1 - 2.8e-82 276.5 0.0 3.4e-82 276.2 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 001080610.1_16126001_1 - 1.1e-62 211.7 32.3 1.1e-62 211.7 32.3 1.7 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 001080610.1_16126001_1 - 7.6e-19 67.3 11.3 1.6e-18 66.2 11.3 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001080610.1_16126001_1 - 1e-16 61.5 0.0 1.7e-15 57.5 0.0 2.0 1 1 0 1 1 1 1 Periplasmic binding protein 7tm_2 PF00002.22 001037834.2_23524001_2 - 3.6e-83 278.5 18.2 4.9e-83 278.1 18.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001037834.2_23524001_2 - 2.4e-20 72.4 1.2 2.4e-20 72.4 1.2 2.1 2 0 0 2 2 2 1 Hormone receptor domain bZIP_1 PF00170.19 001278132.1_23524001_3 - 2.2e-20 72.4 11.0 4e-20 71.5 11.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor pKID PF02173.15 001278132.1_23524001_3 - 5.6e-18 64.0 4.3 1.2e-17 62.9 4.3 1.6 1 0 0 1 1 1 1 pKID domain bZIP_2 PF07716.13 001278132.1_23524001_3 - 8.8e-08 32.0 10.8 1.6e-07 31.2 10.8 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 001278132.1_23524001_3 - 0.0025 18.2 6.2 0.0059 17.0 6.2 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor pKID PF02173.15 001278134.1_23522001_3 - 2e-18 65.5 4.3 3.8e-18 64.5 4.3 1.5 1 0 0 1 1 1 1 pKID domain Ig_2 PF13895.4 001024590.1_23523001_2 - 5.5e-20 71.4 0.9 5.3e-07 29.8 0.2 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 001024590.1_23523001_2 - 1e-19 70.4 1.2 2.3e-08 33.9 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 001024590.1_23523001_2 - 1.3e-17 64.1 0.2 1e-05 25.9 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 001024590.1_23523001_2 - 4.7e-15 55.3 0.2 0.00018 21.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain V-set PF07686.15 001024590.1_23523001_2 - 5.4e-12 45.7 2.6 0.021 14.8 0.1 4.5 3 1 1 4 4 4 3 Immunoglobulin V-set domain Rib PF08428.8 001024590.1_23523001_2 - 0.024 14.5 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 Rib/alpha-like repeat bZIP_1 PF00170.19 001278135.1_23523001_3 - 1.6e-20 72.9 11.0 2.5e-20 72.2 11.0 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001278135.1_23523001_3 - 6.2e-08 32.5 10.8 9.8e-08 31.8 10.8 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 001278135.1_23523001_3 - 0.0023 18.3 6.2 0.0037 17.6 6.2 1.2 1 0 0 1 1 1 1 bZIP Maf transcription factor GAS PF13851.4 001277617.1_23524001_3 - 6.2e-73 244.3 33.2 6.2e-73 244.3 33.2 3.1 1 1 2 3 3 3 1 Growth-arrest specific micro-tubule binding Reo_sigmaC PF04582.10 001277617.1_23524001_3 - 1.2 8.3 8.0 1.2 8.3 0.1 3.2 1 1 2 3 3 3 0 Reovirus sigma C capsid protein TIR PF01582.18 001024591.2_23526001_2 - 1.5e-32 112.7 0.3 2.5e-32 111.9 0.3 1.3 1 0 0 1 1 1 1 TIR domain Ig_2 PF13895.4 001024591.2_23526001_2 - 7.4e-19 67.7 1.0 1.5e-06 28.4 0.2 3.9 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 001024591.2_23526001_2 - 3.8e-17 62.1 6.3 6.5e-08 32.5 0.0 4.1 4 0 0 4 4 4 3 Immunoglobulin domain Ig_3 PF13927.4 001024591.2_23526001_2 - 2e-16 60.2 0.2 3e-05 24.4 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 001024591.2_23526001_2 - 7.6e-14 51.4 0.1 0.00053 19.9 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin I-set domain V-set PF07686.15 001024591.2_23526001_2 - 1.4e-10 41.2 2.5 0.045 13.8 0.1 4.6 3 1 1 4 4 4 3 Immunoglobulin V-set domain TIR_2 PF13676.4 001024591.2_23526001_2 - 0.059 13.6 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 TIR domain Rib PF08428.8 001024591.2_23526001_2 - 0.06 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Rib/alpha-like repeat UPF0492 PF15744.3 001199412.1_23526001_2 - 2.7e-163 543.3 13.6 3.5e-163 543.0 13.6 1.1 1 0 0 1 1 1 1 Uncharacterized protein family UPF0492 ETF PF01012.19 001305470.1_23523001_3 - 1.6e-42 145.3 1.0 2.7e-42 144.6 1.0 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.17 001305470.1_23523001_3 - 1e-37 127.9 0.9 1.9e-37 127.0 0.2 1.9 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain Laminin_G_2 PF02210.22 001198976.1_23529001_1 - 3.1e-22 79.3 0.1 5.1e-22 78.7 0.1 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.21 001198976.1_23529001_1 - 4.2e-09 36.6 0.0 1e-08 35.3 0.0 1.6 1 0 0 1 1 1 1 Laminin G domain Syndecan PF01034.18 001198976.1_23529001_1 - 2.1e-07 30.6 0.0 5.4e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Syndecan domain DUF202 PF02656.13 001198976.1_23529001_1 - 0.064 13.6 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) PLAC9 PF15205.4 001302194.1_23522001_2 - 1.6e-14 53.9 0.1 2.7e-14 53.2 0.1 1.4 1 0 0 1 1 1 1 Placenta-specific protein 9 7tm_3 PF00003.20 001257299.1_23528001_1 - 5.6e-35 121.1 22.4 8e-35 120.6 22.4 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR EGF_3 PF12947.5 001257299.1_23528001_1 - 8.3 6.6 8.8 0.17 11.9 0.4 2.2 2 0 0 2 2 2 0 EGF domain PRIMA1 PF16101.3 001145492.1_23521001_1 - 5.3e-62 207.1 14.4 6.4e-62 206.8 14.4 1.1 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 Cadherin_C_2 PF16492.3 001145492.1_23521001_1 - 0.0075 16.9 0.1 0.015 15.9 0.1 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal S1FA PF04689.11 001145492.1_23521001_1 - 0.044 13.8 0.0 0.073 13.1 0.0 1.3 1 0 0 1 1 1 0 DNA binding protein S1FA TMEM154 PF15102.4 001145492.1_23521001_1 - 0.062 13.1 0.0 0.086 12.6 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family Rax2 PF12768.5 001145492.1_23521001_1 - 0.12 11.9 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity EphA2_TM PF14575.4 001145492.1_23521001_1 - 0.12 13.1 0.2 0.17 12.5 0.2 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain CAP_N PF01213.17 001145492.1_23521001_1 - 3.7 6.8 11.7 6 6.1 11.7 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Thyroglobulin_1 PF00086.16 001101034.1_23522001_1 - 2.1e-18 65.6 3.0 2.1e-18 65.6 3.0 2.2 2 1 0 2 2 2 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 001101034.1_23522001_1 - 5.1e-09 36.5 22.0 5.1e-09 36.5 22.0 2.2 2 0 0 2 2 2 1 Insulin-like growth factor binding protein DUF4829 PF16111.3 001101034.1_23522001_1 - 0.027 15.1 0.0 0.039 14.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4829) Peptidase_S41_N PF11918.6 001024575.1_23528001_1 - 4.5e-120 395.4 11.3 1.4e-39 135.1 0.3 4.5 4 0 0 4 4 4 4 N-terminal domain of Peptidase_S41 in eukaryotic IRBP Peptidase_S41 PF03572.16 001024575.1_23528001_1 - 1.6e-95 317.2 0.0 4.9e-26 91.1 0.0 4.2 4 0 0 4 4 4 4 Peptidase family S41 muHD PF10291.7 001024575.1_23528001_1 - 0.014 14.7 0.0 8.7 5.5 0.0 3.1 3 0 0 3 3 3 0 Muniscin C-terminal mu homology domain SPRY PF00622.26 001031431.1_23524001_2 - 3.3e-15 56.1 0.0 5.5e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 001031431.1_23524001_2 - 2.6e-09 36.9 0.5 5.1e-09 36.0 0.5 1.5 1 0 0 1 1 1 1 B-box zinc finger PRY PF13765.4 001031431.1_23524001_2 - 5.4e-09 35.4 0.2 1.3e-08 34.2 0.2 1.6 1 0 0 1 1 1 1 SPRY-associated domain DUF3793 PF12672.5 001031431.1_23524001_2 - 0.11 12.4 1.3 0.54 10.1 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3793) Mg_trans_NIPA PF05653.12 001030809.1_23523001_1 - 9.8e-148 490.9 15.4 1.1e-147 490.7 15.4 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.18 001030809.1_23523001_1 - 2.9e-09 37.1 4.0 2.9e-09 37.1 4.0 4.3 3 1 0 3 3 3 2 EamA-like transporter family Tissue_fac PF01108.15 001039597.1_23525001_2 - 1.3e-27 95.6 0.0 3.1e-27 94.3 0.0 1.6 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.8 001039597.1_23525001_2 - 4.9e-08 33.1 0.0 1.4e-07 31.6 0.1 1.8 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.19 001039597.1_23525001_2 - 0.005 17.0 1.0 0.84 9.9 0.1 2.6 2 0 0 2 2 2 2 Fibronectin type III domain SR-25 PF10500.7 001039597.1_23525001_2 - 7.6 5.9 9.9 13 5.2 9.9 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IGFBP PF00219.16 001024579.1_23523001_1 - 6.5e-11 42.6 20.7 6.5e-11 42.6 20.7 4.9 4 3 0 4 4 4 1 Insulin-like growth factor binding protein Cys_knot PF00007.20 001024579.1_23523001_1 - 2.2e-09 37.4 9.4 2.2e-09 37.4 9.4 3.6 4 1 0 4 4 4 1 Cystine-knot domain VWC PF00093.16 001024579.1_23523001_1 - 1.8e-08 34.4 12.2 1.8e-08 34.4 12.2 5.3 4 3 0 4 4 4 1 von Willebrand factor type C domain TSP_1 PF00090.17 001024579.1_23523001_1 - 5.1e-07 29.7 3.7 5.1e-07 29.7 3.7 3.6 4 0 0 4 4 4 1 Thrombospondin type 1 domain Amidohydro_1 PF01979.18 001345995.1_23526001_1 - 5.8e-18 65.2 0.5 7.9e-18 64.7 0.5 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 001345995.1_23526001_1 - 3.1e-08 33.4 0.2 2.2e-06 27.3 0.1 2.2 2 0 0 2 2 2 2 Amidohydrolase family DUF846 PF05832.10 001281876.1_02222001_2 - 4.8e-54 182.1 8.6 6.8e-54 181.6 8.6 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) DUF2079 PF09852.7 001281876.1_02222001_2 - 0.057 12.1 4.0 0.066 11.9 0.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2079) 7tm_1 PF00001.19 001007218.1_16123001_1 - 3.4e-48 164.1 20.6 4.6e-48 163.6 20.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001007218.1_16123001_1 - 7.4e-09 35.2 19.2 1.1e-08 34.7 19.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001007218.1_16123001_1 - 0.23 11.0 16.1 0.38 10.3 16.1 1.5 1 1 0 1 1 1 0 Olfactory receptor EVI2A PF05399.9 001080893.1_23524001_3 - 1.1e-93 312.9 0.8 1.4e-93 312.6 0.8 1.1 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) Baculo_11_kDa PF06143.9 001080893.1_23524001_3 - 1.8 8.0 5.1 0.93 9.0 0.3 2.3 2 0 0 2 2 2 0 Baculovirus 11 kDa family Homeobox PF00046.27 205198.1_23522001_2 - 2.4e-21 75.2 3.1 3.5e-21 74.6 3.1 1.3 1 0 0 1 1 1 1 Homeobox domain TPD52 PF04201.13 001079754.1_23524001_1 - 1.6e-72 242.3 11.7 2.6e-72 241.6 11.7 1.3 1 0 0 1 1 1 1 Tumour protein D52 family GAS PF13851.4 001079754.1_23524001_1 - 0.1 11.8 7.4 0.15 11.3 7.4 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding PEP-utilisers_N PF05524.11 001079754.1_23524001_1 - 0.11 12.6 2.6 0.19 11.8 2.6 1.3 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal Cob_adeno_trans PF01923.16 001079754.1_23524001_1 - 0.2 11.6 1.6 0.33 10.9 1.6 1.3 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Occludin_ELL PF07303.11 001079754.1_23524001_1 - 0.26 11.9 4.2 2.4 8.8 0.5 2.2 1 1 1 2 2 2 0 Occludin homology domain WXG100 PF06013.10 001079754.1_23524001_1 - 0.48 10.5 4.3 7.5 6.7 0.3 2.5 2 0 0 2 2 2 0 Proteins of 100 residues with WXG IncA PF04156.12 001079754.1_23524001_1 - 0.51 10.0 10.5 1.2 8.8 10.6 1.5 1 1 0 1 1 1 0 IncA protein OmpH PF03938.12 001079754.1_23524001_1 - 0.6 10.0 7.7 1.1 9.2 7.7 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Uds1 PF15456.4 001079754.1_23524001_1 - 0.69 10.0 9.9 1.4 9.0 9.9 1.5 1 1 0 1 1 1 0 Up-regulated During Septation HsbA PF12296.6 001079754.1_23524001_1 - 0.94 9.8 6.9 0.75 10.1 0.8 2.3 1 1 1 2 2 2 0 Hydrophobic surface binding protein A TBPIP PF07106.11 001079754.1_23524001_1 - 1.1 8.9 11.4 1.2 8.8 8.6 1.9 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) KxDL PF10241.7 001079754.1_23524001_1 - 1.6 8.9 6.5 6.6 7.0 0.2 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein Cnn_1N PF07989.9 001079754.1_23524001_1 - 1.8 8.6 7.9 0.6 10.2 4.8 1.8 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Wx5_PLAF3D7 PF09688.8 001079754.1_23524001_1 - 1.8 8.4 5.1 3.3 7.6 5.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (Wx5_PLAF3D7) Mnd1 PF03962.13 001079754.1_23524001_1 - 2.6 7.8 11.5 2 8.1 10.1 1.4 1 1 0 1 1 1 0 Mnd1 family AAA_13 PF13166.4 001079754.1_23524001_1 - 3.6 6.0 10.7 11 4.4 10.7 1.5 1 1 0 1 1 1 0 AAA domain CAP PF00188.24 001030743.2_23523001_2 - 4.9e-26 91.9 2.6 7.2e-26 91.4 2.6 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family BBL5 PF07289.9 001252031.1_23525001_1 - 1.9e-157 523.4 0.1 2.4e-157 523.1 0.1 1.1 1 0 0 1 1 1 1 Bardet-Biedl syndrome 5 protein Vps36_ESCRT-II PF11605.6 001252031.1_23525001_1 - 0.0022 18.0 0.0 0.57 10.3 0.0 2.4 2 0 0 2 2 2 2 Vacuolar protein sorting protein 36 Vps36 bPH_3 PF14470.4 001252031.1_23525001_1 - 0.0027 17.9 0.0 0.036 14.3 0.0 2.3 2 0 0 2 2 2 1 Bacterial PH domain PH_TFIIH PF08567.9 001252031.1_23525001_1 - 0.0047 17.1 0.0 0.31 11.3 0.0 2.4 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain Voldacs PF03517.11 001252031.1_23525001_1 - 0.08 12.9 0.2 5.2 7.0 0.1 2.5 2 0 0 2 2 2 0 Regulator of volume decrease after cellular swelling zf-C2H2 PF00096.24 001168709.1_23523001_1 - 6.5e-13 48.2 25.4 0.00017 21.7 4.5 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001168709.1_23523001_1 - 1.1e-11 44.5 26.0 3.4e-06 27.1 0.7 4.3 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001168709.1_23523001_1 - 3e-08 33.7 22.6 0.011 16.4 2.6 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001168709.1_23523001_1 - 6.2e-07 29.1 14.5 8.2e-05 22.3 1.3 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-AN1 PF01428.14 001168709.1_23523001_1 - 0.00075 19.5 10.9 0.045 13.8 1.2 3.5 3 0 0 3 3 3 2 AN1-like Zinc finger zf-C2H2_jaz PF12171.6 001168709.1_23523001_1 - 0.0018 18.4 14.4 0.11 12.7 1.4 3.6 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding C1_4 PF07975.10 001168709.1_23523001_1 - 0.0038 17.3 11.1 0.32 11.2 5.8 2.7 1 1 2 3 3 3 2 TFIIH C1-like domain Zn-ribbon_8 PF09723.8 001168709.1_23523001_1 - 0.0048 16.9 8.3 0.025 14.6 1.7 2.4 2 0 0 2 2 2 1 Zinc ribbon domain XPA_N PF01286.16 001168709.1_23523001_1 - 0.023 14.6 7.7 0.43 10.5 0.8 3.4 3 0 0 3 3 3 0 XPA protein N-terminal zf-met PF12874.5 001168709.1_23523001_1 - 0.031 14.5 0.9 0.031 14.5 0.9 3.3 4 0 0 4 4 3 0 Zinc-finger of C2H2 type GAGA PF09237.9 001168709.1_23523001_1 - 0.079 12.7 2.9 0.17 11.6 0.4 2.3 1 1 1 2 2 2 0 GAGA factor CpXC PF14353.4 001168709.1_23523001_1 - 0.37 10.7 7.1 0.41 10.5 0.1 2.7 1 1 2 3 3 3 0 CpXC protein FYVE PF01363.19 001168709.1_23523001_1 - 1.6 8.8 14.3 0.79 9.8 7.1 2.4 1 1 1 2 2 2 0 FYVE zinc finger LIM PF00412.20 001168709.1_23523001_1 - 3.6 7.8 12.2 16 5.7 0.2 2.8 1 1 0 2 2 2 0 LIM domain zf-trcl PF13451.4 001168709.1_23523001_1 - 6.7 6.5 11.3 7.5 6.4 0.2 3.1 3 0 0 3 3 3 0 Probable zinc-ribbon domain zf-Di19 PF05605.10 001168709.1_23523001_1 - 8.4 6.6 10.9 0.38 10.9 3.9 2.1 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding VKOR PF07884.12 001001328.2_23523001_3 - 4.1e-25 88.2 11.8 8.4e-25 87.2 11.8 1.5 1 0 0 1 1 1 1 Vitamin K epoxide reductase family SPC25 PF06703.9 001001328.2_23523001_3 - 2 8.1 6.8 3.7 7.2 6.8 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Filament PF00038.19 001001195.2_23526001_3 - 1.1e-114 383.2 34.7 1.2e-114 382.9 34.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001001195.2_23526001_3 - 2.8e-41 141.2 51.6 2.8e-41 141.2 51.6 2.9 2 1 0 2 2 1 1 Keratin type II head TPR_MLP1_2 PF07926.10 001001195.2_23526001_3 - 1.7e-07 31.2 27.3 0.00028 20.8 11.7 3.6 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein AAA_13 PF13166.4 001001195.2_23526001_3 - 4.7e-05 22.1 11.7 4.7e-05 22.1 11.7 1.7 1 1 0 1 1 1 1 AAA domain Spc7 PF08317.9 001001195.2_23526001_3 - 0.0014 17.4 31.7 0.048 12.4 15.4 3.0 1 1 2 3 3 3 3 Spc7 kinetochore protein CENP-F_leu_zip PF10473.7 001001195.2_23526001_3 - 0.0049 16.8 26.7 0.13 12.2 4.9 3.3 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MukF_M PF17192.2 001001195.2_23526001_3 - 0.0084 15.7 13.8 0.044 13.4 7.0 2.2 2 0 0 2 2 2 1 MukF middle domain ApoLp-III PF07464.9 001001195.2_23526001_3 - 0.012 15.5 2.3 0.012 15.5 2.3 2.8 1 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Alanine_zipper PF11839.6 001001195.2_23526001_3 - 0.017 15.3 6.2 0.054 13.6 6.2 1.8 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein Baculo_PEP_C PF04513.10 001001195.2_23526001_3 - 0.02 14.8 0.5 0.02 14.8 0.5 4.1 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.4 001001195.2_23526001_3 - 0.03 13.6 16.5 0.032 13.4 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF1451 PF07295.9 001001195.2_23526001_3 - 0.078 12.9 12.1 0.24 11.3 1.8 2.5 2 0 0 2 2 2 0 Zinc-ribbon containing domain Jnk-SapK_ap_N PF09744.7 001001195.2_23526001_3 - 0.13 12.3 27.0 0.026 14.6 1.7 3.3 1 1 1 3 3 3 0 JNK_SAPK-associated protein-1 DUF1664 PF07889.10 001001195.2_23526001_3 - 0.23 11.3 15.0 1.6 8.6 1.2 4.3 3 1 0 4 4 4 0 Protein of unknown function (DUF1664) IncA PF04156.12 001001195.2_23526001_3 - 0.38 10.4 27.6 0.15 11.7 8.4 3.6 2 1 0 2 2 2 0 IncA protein ADIP PF11559.6 001001195.2_23526001_3 - 0.43 10.5 25.2 0.77 9.7 2.6 3.6 2 2 0 3 3 3 0 Afadin- and alpha -actinin-Binding Reo_sigmaC PF04582.10 001001195.2_23526001_3 - 0.47 9.7 7.0 0.48 9.6 1.0 2.4 2 1 0 2 2 2 0 Reovirus sigma C capsid protein DUF3502 PF12010.6 001001195.2_23526001_3 - 0.49 10.9 2.3 1.3 9.5 2.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3502) DUF948 PF06103.9 001001195.2_23526001_3 - 0.64 10.2 4.5 4.3 7.5 0.7 3.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF5082 PF16888.3 001001195.2_23526001_3 - 1.5 9.1 19.9 0.16 12.1 3.5 3.7 2 1 2 4 4 4 0 Domain of unknown function (DUF5082) ACCA PF03255.12 001001195.2_23526001_3 - 1.8 8.3 17.1 1.3 8.7 0.7 3.6 2 1 0 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Golgin_A5 PF09787.7 001001195.2_23526001_3 - 1.8 7.8 29.6 0.16 11.3 10.0 3.5 1 1 3 4 4 4 0 Golgin subfamily A member 5 T3SS_needle_E PF08988.8 001001195.2_23526001_3 - 2.2 8.4 7.2 0.82 9.8 2.5 2.5 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle ABC_tran_CTD PF16326.3 001001195.2_23526001_3 - 4.4 7.5 18.3 2.4 8.3 9.8 3.2 2 1 1 3 3 3 0 ABC transporter C-terminal domain Sec34 PF04136.13 001001195.2_23526001_3 - 6 6.6 12.7 0.69 9.7 2.4 3.2 2 1 1 3 3 3 0 Sec34-like family TSC22 PF01166.16 001001195.2_23526001_3 - 6.8 6.9 12.7 8.7 6.6 0.2 4.3 3 2 1 4 4 4 0 TSC-22/dip/bun family Tox-ODYAM1 PF15642.4 001001195.2_23526001_3 - 7.2 5.3 14.1 1.2 7.9 6.8 2.4 1 1 2 3 3 3 0 Toxin in Odyssella and Amoebophilus DUF883 PF05957.11 001001195.2_23526001_3 - 7.6 7.1 19.2 0.97 9.9 5.9 4.4 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF883) Sdh5 PF03937.14 001277890.1_23522001_2 - 1.5e-23 82.4 0.5 2.1e-23 81.9 0.5 1.2 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase RTTN_N PF14726.4 001277890.1_23522001_2 - 0.016 15.9 0.3 3 8.6 0.0 2.1 2 0 0 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning DUF1689 PF07954.9 001277890.1_23522001_2 - 0.064 13.5 0.1 0.086 13.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1689) TFIIE_alpha PF02002.15 001277890.1_23522001_2 - 0.071 12.8 0.4 0.1 12.3 0.4 1.2 1 0 0 1 1 1 0 TFIIE alpha subunit PRMT5 PF05185.14 001320230.1_23524001_1 - 1.2e-161 538.7 0.0 1.5e-161 538.3 0.0 1.0 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase SAMBD PF16950.3 001320230.1_23524001_1 - 3.7e-95 318.8 0.0 1.1e-74 251.5 0.0 2.1 1 1 1 2 2 2 2 SAM-binding_domain Methyltransf_25 PF13649.4 001320230.1_23524001_1 - 0.00066 20.2 0.0 0.0011 19.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.14 001320230.1_23524001_1 - 0.01 15.5 0.0 0.016 14.9 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein EMG1 PF03587.12 103452.1_23522120_1 - 9e-45 152.6 0.0 1.2e-44 152.2 0.0 1.2 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase EMG1 PF03587.12 103452.1_23522120_2 - 2.3e-31 108.8 0.0 3e-31 108.4 0.0 1.1 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase zf-C2H2 PF00096.24 001318990.1_23522001_1 - 5.4e-14 51.6 31.4 4.4e-05 23.6 8.7 3.7 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001318990.1_23522001_1 - 2.3e-09 37.2 14.3 1.6e-05 25.0 0.8 4.4 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001318990.1_23522001_1 - 7.5e-07 29.3 26.7 0.0089 16.6 6.1 4.1 4 0 0 4 4 4 3 C2H2-type zinc finger DUF3850 PF12961.5 001318990.1_23522001_1 - 0.11 12.6 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3850) FOXP-CC PF16159.3 001318990.1_23522001_1 - 0.64 10.5 8.0 9.2 6.8 3.1 3.2 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_8 PF15909.3 001318990.1_23522001_1 - 0.9 9.8 10.8 0.16 12.1 6.1 2.2 2 1 1 3 3 3 0 C2H2-type zinc ribbon NDUFA12 PF05071.14 001199230.1_23522001_3 - 6.2e-12 46.1 5.6 9.5e-12 45.5 5.6 1.4 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Peptidase_M14 PF00246.22 001277445.1_23523001_3 - 1.2e-90 304.1 0.0 1.4e-90 303.9 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.14 001277445.1_23523001_3 - 1.1e-19 70.4 1.9 2.7e-19 69.2 1.9 1.7 1 0 0 1 1 1 1 Carboxypeptidase activation peptide DUF3514 PF12027.6 001277445.1_23523001_3 - 0.098 12.2 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3514) RRM_1 PF00076.20 001012592.1_23525001_2 - 1e-20 73.2 0.0 3.4e-10 39.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Synuclein PF01387.15 204672.1_23522001_2 - 1.5e-54 183.6 21.3 2e-54 183.3 21.3 1.1 1 0 0 1 1 1 1 Synuclein Chromo_shadow PF01393.17 204332.1_23523001_3 - 4e-33 113.1 0.2 4.6e-30 103.3 0.0 2.4 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.22 204332.1_23523001_3 - 4.6e-21 74.3 0.3 1.6e-17 62.9 0.4 2.7 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.4 204332.1_23523001_3 - 0.0065 16.5 0.2 0.03 14.3 0.2 2.0 2 0 0 2 2 2 1 Polycomb-like MTF2 factor 2 p450 PF00067.20 001001751.2_23524001_2 - 6.8e-124 414.0 0.1 7.8e-124 413.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Tctex-1 PF03645.11 001277734.1_23525001_3 - 5.1e-29 100.4 2.3 8.3e-29 99.7 2.3 1.3 1 0 0 1 1 1 1 Tctex-1 family 2OG-FeII_Oxy_2 PF13532.4 001277499.1_23523001_1 - 3.7e-19 69.6 0.1 5e-19 69.2 0.1 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_2 PF13532.4 001277501.1_23523001_3 - 5.5e-19 69.0 0.1 8e-19 68.5 0.1 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MACPF PF01823.17 001321543.1_23529001_3 - 1.2e-34 120.2 0.0 1.7e-34 119.6 0.0 1.2 1 0 0 1 1 1 1 MAC/Perforin domain Ldl_recept_a PF00057.16 001321543.1_23529001_3 - 3.5e-09 36.6 9.0 1.4e-08 34.7 9.0 2.1 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A TSP_1 PF00090.17 001321543.1_23529001_3 - 8.2e-06 25.8 25.1 1.4e-05 25.1 10.4 3.5 4 0 0 4 4 4 2 Thrombospondin type 1 domain Shugoshin_C PF07557.9 001199648.1_23525001_2 - 5.8e-08 32.2 2.5 5.8e-08 32.2 2.5 2.1 2 0 0 2 2 2 1 Shugoshin C terminus SMAP PF15477.4 001277809.1_23524001_2 - 6.8e-17 62.0 1.6 6.8e-17 62.0 1.6 3.9 2 1 0 2 2 2 1 Small acidic protein family HMG_box PF00505.17 001039326.1_23524001_2 - 8.8e-26 90.0 1.5 1.4e-25 89.4 1.5 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box Sox17_18_mid PF12067.6 001039326.1_23524001_2 - 5.1e-14 51.9 4.5 1.5e-13 50.4 4.4 1.9 2 0 0 2 2 2 1 Sox 17/18 central domain HMG_box_2 PF09011.8 001039326.1_23524001_2 - 1.3e-11 44.8 1.3 2.2e-11 44.0 1.3 1.4 1 0 0 1 1 1 1 HMG-box domain HTH_24 PF13412.4 001039326.1_23524001_2 - 0.13 11.7 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Sulfate_transp PF00916.18 001252254.1_23526001_2 - 3.9e-108 361.5 24.3 1.4e-107 359.6 24.3 1.8 1 1 0 1 1 1 1 Sulfate permease family STAS PF01740.19 001252254.1_23526001_2 - 7.2e-23 80.3 0.0 1.5e-22 79.3 0.0 1.5 1 0 0 1 1 1 1 STAS domain SR-25 PF10500.7 001252254.1_23526001_2 - 0.0011 18.5 3.7 0.0018 17.8 3.7 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein ETRAMP PF09716.8 001252254.1_23526001_2 - 2.4 8.1 7.1 7.4 6.6 5.4 2.5 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Apolipoprotein PF01442.16 204938.2_23523001_1 - 1.1e-71 240.7 44.8 3.9e-52 176.9 20.0 2.9 2 1 1 3 3 3 2 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.9 204938.2_23523001_1 - 2e-09 37.5 30.2 7.9e-06 25.9 2.6 4.6 1 1 3 4 4 4 4 Apolipophorin-III precursor (apoLp-III) YtxH PF12732.5 204938.2_23523001_1 - 3.8e-09 36.8 15.8 0.011 16.1 0.0 6.3 2 2 3 5 5 5 2 YtxH-like protein Baculo_PEP_C PF04513.10 204938.2_23523001_1 - 4.7e-09 36.3 23.6 0.045 13.7 1.2 5.7 1 1 5 6 6 6 4 Baculovirus polyhedron envelope protein, PEP, C terminus DUF883 PF05957.11 204938.2_23523001_1 - 2.4e-07 31.1 30.2 0.25 11.8 0.7 5.9 1 1 5 6 6 6 6 Bacterial protein of unknown function (DUF883) AAA_13 PF13166.4 204938.2_23523001_1 - 3.1e-05 22.7 4.2 3.1e-05 22.7 4.2 2.3 1 1 1 2 2 2 1 AAA domain Fzo_mitofusin PF04799.11 204938.2_23523001_1 - 4.2e-05 23.0 25.4 0.00074 18.9 1.7 5.1 1 1 5 6 6 6 1 fzo-like conserved region DUF4795 PF16043.3 204938.2_23523001_1 - 4.2e-05 23.1 24.0 0.0038 16.7 5.1 4.0 1 1 2 3 3 3 1 Domain of unknown function (DUF4795) Prominin PF05478.9 204938.2_23523001_1 - 7e-05 20.9 18.5 0.00024 19.1 4.2 2.2 1 1 1 2 2 2 2 Prominin SHE3 PF17078.3 204938.2_23523001_1 - 8.8e-05 22.2 14.5 0.12 11.9 0.9 3.6 1 1 2 3 3 3 2 SWI5-dependent HO expression protein 3 Exonuc_VII_L PF02601.13 204938.2_23523001_1 - 0.0001 21.9 32.2 0.31 10.4 13.1 3.0 1 1 1 2 2 2 1 Exonuclease VII, large subunit DUF1664 PF07889.10 204938.2_23523001_1 - 0.00011 22.0 17.4 0.37 10.6 1.9 4.6 1 1 3 4 4 4 3 Protein of unknown function (DUF1664) DUF4407 PF14362.4 204938.2_23523001_1 - 0.00031 20.1 28.9 0.00092 18.5 8.6 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF4407) ApoO PF09769.7 204938.2_23523001_1 - 0.00085 19.2 10.9 0.8 9.5 0.1 5.3 1 1 2 3 3 3 1 Apolipoprotein O BshC PF10079.7 204938.2_23523001_1 - 0.00099 17.8 25.8 0.052 12.2 6.7 3.5 1 1 2 3 3 3 2 Bacillithiol biosynthesis BshC F_actin_bind PF08919.8 204938.2_23523001_1 - 0.001 19.0 13.4 0.11 12.4 0.9 3.9 1 1 2 4 4 4 2 F-actin binding Dynamin_M PF01031.18 204938.2_23523001_1 - 0.0018 17.4 1.5 0.0018 17.4 1.5 2.7 1 1 1 2 2 2 1 Dynamin central region DUF948 PF06103.9 204938.2_23523001_1 - 0.0019 18.3 14.1 0.88 9.7 1.8 5.7 1 1 2 3 3 3 1 Bacterial protein of unknown function (DUF948) Gp58 PF07902.9 204938.2_23523001_1 - 0.0021 16.5 5.5 0.0021 16.5 5.5 2.0 1 1 1 2 2 2 1 gp58-like protein Tht1 PF04163.10 204938.2_23523001_1 - 0.0032 16.2 0.7 0.0054 15.4 0.7 1.3 1 0 0 1 1 1 1 Tht1-like nuclear fusion protein SF-assemblin PF06705.9 204938.2_23523001_1 - 0.004 16.4 13.9 1.7 7.8 3.5 3.3 1 1 1 2 2 2 2 SF-assemblin/beta giardin Lipoprotein_7 PF01540.14 204938.2_23523001_1 - 0.0053 16.0 0.4 0.016 14.4 0.2 1.9 1 1 1 2 2 2 1 Adhesin lipoprotein OmpH PF03938.12 204938.2_23523001_1 - 0.0076 16.1 48.4 0.04 13.8 12.2 4.6 1 1 3 4 4 4 2 Outer membrane protein (OmpH-like) ZYG-11_interact PF05884.10 204938.2_23523001_1 - 0.0086 15.4 9.4 0.33 10.2 2.9 3.6 1 1 2 3 3 3 1 Interactor of ZYG-11 DUF4455 PF14643.4 204938.2_23523001_1 - 0.0088 14.7 28.0 1.2 7.6 10.5 3.1 1 1 0 2 2 2 1 Domain of unknown function (DUF4455) Fib_alpha PF08702.8 204938.2_23523001_1 - 0.015 15.4 19.0 0.43 10.6 5.7 3.5 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family DUF4854 PF16146.3 204938.2_23523001_1 - 0.022 15.0 13.1 2 8.6 0.2 5.8 2 1 3 6 6 6 0 Domain of unknown function (DUF4854) Nnf1 PF03980.12 204938.2_23523001_1 - 0.033 14.4 40.8 0.95 9.7 0.5 5.9 3 3 2 5 5 5 0 Nnf1 WXG100 PF06013.10 204938.2_23523001_1 - 0.038 14.1 29.0 7.2 6.8 4.8 6.0 1 1 4 5 5 5 0 Proteins of 100 residues with WXG DUF4456 PF14644.4 204938.2_23523001_1 - 0.048 13.2 26.9 0.12 11.9 0.4 4.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4456) DUF1845 PF08900.9 204938.2_23523001_1 - 0.048 13.2 19.0 0.92 9.0 0.1 5.5 1 1 6 7 7 7 0 Domain of unknown function (DUF1845) Phage_Mu_Gam PF07352.10 204938.2_23523001_1 - 0.049 13.4 27.5 0.86 9.4 2.2 5.4 1 1 5 6 6 6 0 Bacteriophage Mu Gam like protein Phasin PF05597.9 204938.2_23523001_1 - 0.05 13.5 21.8 0.26 11.2 0.5 4.8 1 1 2 4 4 4 0 Poly(hydroxyalcanoate) granule associated protein (phasin) FUSC PF04632.10 204938.2_23523001_1 - 0.061 11.8 33.6 0.053 11.9 13.6 2.9 2 1 1 3 3 3 0 Fusaric acid resistance protein family Mst1_SARAH PF11629.6 204938.2_23523001_1 - 0.067 13.2 0.7 0.067 13.2 0.7 6.1 3 2 4 7 7 6 0 C terminal SARAH domain of Mst1 DUF885 PF05960.9 204938.2_23523001_1 - 0.1 12.1 26.1 0.25 10.8 25.7 1.9 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF885) DUF2884 PF11101.6 204938.2_23523001_1 - 0.2 11.0 25.1 1.5 8.1 3.1 4.0 1 1 3 4 4 4 0 Protein of unknown function (DUF2884) ZnuA PF01297.15 204938.2_23523001_1 - 0.56 9.4 17.5 5.9 6.1 0.0 5.2 1 1 3 5 5 5 0 Zinc-uptake complex component A periplasmic DUF1116 PF06545.9 204938.2_23523001_1 - 0.61 9.4 4.1 2.3 7.5 0.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1116) AI-2E_transport PF01594.14 204938.2_23523001_1 - 0.63 9.0 7.1 0.53 9.2 0.2 3.3 1 1 3 4 4 4 0 AI-2E family transporter T7SS_ESX_EspC PF10824.6 204938.2_23523001_1 - 0.84 10.0 14.4 8.1 6.9 4.9 4.4 1 1 3 5 5 5 0 Excreted virulence factor EspC, type VII ESX diderm Baculo_p24 PF05073.10 204938.2_23523001_1 - 0.94 9.1 7.6 12 5.5 0.1 3.2 2 1 1 3 3 3 0 Baculovirus P24 capsid protein Mit_KHE1 PF10173.7 204938.2_23523001_1 - 1 9.3 5.9 3.1e+02 1.2 5.8 3.5 1 1 0 1 1 1 0 Mitochondrial K+-H+ exchange-related FliT PF05400.11 204938.2_23523001_1 - 1.6 9.5 47.8 2.3 9.0 1.6 5.4 1 1 2 3 3 2 0 Flagellar protein FliT CorA PF01544.16 204938.2_23523001_1 - 3.1 6.9 24.1 1.1 8.4 6.7 2.7 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein DUF1043 PF06295.10 204938.2_23523001_1 - 4.6 7.1 34.7 2.6 7.9 7.0 4.6 1 1 3 4 4 4 0 Protein of unknown function (DUF1043) DUF3584 PF12128.6 204938.2_23523001_1 - 4.8 4.4 39.4 5 4.4 18.8 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Allexi_40kDa PF05549.9 204938.2_23523001_1 - 9.7 5.5 12.7 4.6 6.5 0.1 3.1 1 1 2 3 3 3 0 Allexivirus 40kDa protein Mito_carr PF00153.25 001006443.1_23524001_1 - 7.1e-67 221.3 3.8 2e-24 85.2 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein PDGF PF00341.15 204568.2_23525001_1 - 4.5e-23 81.2 9.5 2.7e-22 78.7 9.5 2.5 1 0 0 1 1 1 1 PDGF/VEGF domain ER_lumen_recept PF00810.16 001159715.1_23524001_3 - 2.7e-55 187.1 9.1 2.7e-55 187.1 9.1 2.0 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.12 001159715.1_23524001_3 - 0.29 10.8 12.5 0.23 11.1 1.3 3.3 3 1 0 3 3 3 0 PQ loop repeat wnt PF00110.17 001007594.2_23523001_2 - 2.1e-117 391.9 16.0 2.4e-117 391.7 16.0 1.0 1 0 0 1 1 1 1 wnt family zf-CCCH_3 PF15663.3 001163339.3_23529001_3 - 1.5e-05 25.0 7.8 0.0098 16.0 0.4 2.7 2 0 0 2 2 2 2 Zinc-finger containing family Torus PF16131.3 001163339.3_23529001_3 - 0.028 15.0 18.2 0.25 11.9 0.2 4.5 2 2 2 4 4 4 0 Torus domain zf-CCCH_2 PF14608.4 001163339.3_23529001_3 - 0.039 14.3 25.2 3.7 8.0 0.8 5.4 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger TPR_1 PF00515.26 001031379.2_23525001_1 - 4.2e-27 92.7 4.3 9.9e-10 37.7 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat SGTA_dimer PF16546.3 001031379.2_23525001_1 - 3.5e-21 74.6 0.5 8.4e-21 73.4 0.0 1.9 2 0 0 2 2 2 1 Homodimerisation domain of SGTA TPR_2 PF07719.15 001031379.2_23525001_1 - 1.7e-18 65.0 4.7 1.4e-05 24.7 0.0 3.7 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_8 PF13181.4 001031379.2_23525001_1 - 5.5e-18 63.5 3.9 5.2e-07 29.2 0.1 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.4 001031379.2_23525001_1 - 4.8e-15 54.8 7.3 1.5e-06 27.6 0.3 3.8 2 1 2 4 4 4 3 TPR repeat TPR_17 PF13431.4 001031379.2_23525001_1 - 3.3e-13 48.9 3.6 4.6e-06 26.5 0.3 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.4 001031379.2_23525001_1 - 1.2e-10 40.5 0.3 0.0051 16.6 0.0 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 001031379.2_23525001_1 - 9.5e-09 35.2 0.0 0.049 14.3 0.0 3.9 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 001031379.2_23525001_1 - 3.3e-08 33.8 0.2 5.9e-05 23.4 0.0 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.4 001031379.2_23525001_1 - 4.3e-08 33.6 1.4 3e-05 24.5 0.2 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.4 001031379.2_23525001_1 - 1.3e-07 31.6 2.0 1.6e-06 28.2 0.2 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.4 001031379.2_23525001_1 - 1.1e-06 28.2 3.2 0.021 14.6 0.1 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 001031379.2_23525001_1 - 0.00024 21.0 1.7 0.15 12.0 0.1 2.8 2 1 1 3 3 2 2 Fis1 C-terminal tetratricopeptide repeat TOM20_plant PF06552.10 001031379.2_23525001_1 - 0.00077 19.1 0.3 0.8 9.3 0.0 2.5 2 0 0 2 2 2 2 Plant specific mitochondrial import receptor subunit TOM20 TPR_9 PF13371.4 001031379.2_23525001_1 - 0.00085 19.3 0.0 0.0041 17.1 0.0 2.2 2 1 0 2 2 1 1 Tetratricopeptide repeat TPR_6 PF13174.4 001031379.2_23525001_1 - 0.0035 17.8 0.3 3.3 8.4 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat NARP1 PF12569.6 001031379.2_23525001_1 - 0.028 13.2 0.1 3.7 6.2 0.1 2.2 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 DUF627 PF04781.10 001031379.2_23525001_1 - 0.043 13.7 0.3 0.46 10.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF627) BTAD PF03704.15 001031379.2_23525001_1 - 0.048 14.0 0.4 1.3 9.3 0.1 2.3 1 1 1 2 2 2 0 Bacterial transcriptional activator domain TPR_15 PF13429.4 001031379.2_23525001_1 - 0.057 12.5 0.0 4.7 6.2 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat XPC-binding PF09280.9 001031379.2_23525001_1 - 0.68 9.6 9.1 3.6 7.3 4.2 2.5 2 0 0 2 2 2 0 XPC-binding domain MIT PF04212.16 001031379.2_23525001_1 - 6.9 6.7 8.8 22 5.1 0.2 3.9 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Pkinase PF00069.23 001006217.2_23523001_2 - 1.1e-77 260.9 0.0 1.4e-77 260.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001006217.2_23523001_2 - 7.9e-33 113.7 0.0 1e-32 113.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001006217.2_23523001_2 - 4.2e-10 39.3 0.0 1.2e-08 34.5 0.0 2.1 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.12 001006217.2_23523001_2 - 2.7e-07 30.0 0.4 5.8e-07 28.9 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 001006217.2_23523001_2 - 0.00016 21.2 0.2 0.00033 20.2 0.2 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 001006217.2_23523001_2 - 0.001 18.9 0.5 0.39 10.5 0.3 2.6 2 1 1 3 3 3 2 Phosphotransferase enzyme family FTA2 PF13095.4 001006217.2_23523001_2 - 0.012 15.1 0.1 1.4 8.3 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.18 001006217.2_23523001_2 - 0.024 14.1 0.3 0.046 13.2 0.3 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase ArfGap PF01412.16 001033871.2_23525001_3 - 2.4e-31 108.0 0.8 5.7e-31 106.8 0.8 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Terminase_4 PF05119.10 001033871.2_23525001_3 - 1.6 9.1 4.7 29 5.0 0.1 2.5 2 0 0 2 2 2 0 Phage terminase, small subunit WD40 PF00400.30 001030914.2_23528001_1 - 2.6e-09 37.4 15.5 0.00086 19.9 2.0 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001030914.2_23528001_1 - 5e-08 33.0 0.1 0.07 13.3 0.0 3.7 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain DUF2457 PF10446.7 001030914.2_23528001_1 - 0.19 10.7 5.3 0.28 10.2 5.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) BUD22 PF09073.8 001030914.2_23528001_1 - 5.4 6.1 11.9 7.8 5.6 11.9 1.1 1 0 0 1 1 1 0 BUD22 RRP7 PF12923.5 001277371.1_23523001_3 - 6.8e-38 129.6 10.9 8.8e-38 129.3 10.9 1.1 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) RRM_1 PF00076.20 001277371.1_23523001_3 - 1.1e-05 25.1 0.0 0.0011 18.6 0.0 2.5 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF5093 PF17011.3 001277371.1_23523001_3 - 0.021 15.0 1.5 0.041 14.0 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5093) Trans_reg_C PF00486.26 001277371.1_23523001_3 - 0.1 12.6 1.4 1.2 9.1 0.6 2.3 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal Clathrin_lg_ch PF01086.15 001030609.2_23526001_2 - 1.5e-57 195.1 12.5 1.9e-57 194.7 12.5 1.1 1 0 0 1 1 1 1 Clathrin light chain GED PF02212.16 001030609.2_23526001_2 - 0.32 11.0 1.1 0.65 10.0 1.1 1.4 1 0 0 1 1 1 0 Dynamin GTPase effector domain FKBP_N PF01346.16 001030609.2_23526001_2 - 5 7.4 6.4 9.4 6.5 6.4 1.4 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase TEA PF01285.16 001199405.1_23525001_1 - 1.1e-26 93.8 0.2 2.1e-26 93.0 0.1 1.4 2 0 0 2 2 2 1 TEA/ATTS domain family SPRY PF00622.26 001031395.1_23525001_1 - 1.8e-11 44.1 0.2 0.00026 21.0 0.0 2.4 2 0 0 2 2 2 2 SPRY domain Transglut_C PF00927.20 204685.1_23527001_1 - 1.1e-40 137.9 0.8 1.6e-23 82.7 0.2 2.7 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_N PF00868.18 204685.1_23527001_1 - 2e-34 118.4 0.0 2.2e-33 115.0 0.0 2.3 2 0 0 2 2 2 1 Transglutaminase family Transglut_core PF01841.17 204685.1_23527001_1 - 1.3e-16 60.9 0.1 2.4e-16 60.1 0.1 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily S-AdoMet_synt_C PF02773.14 001199519.1_23525001_3 - 4.8e-68 227.3 0.1 8.9e-68 226.5 0.1 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.14 001199519.1_23525001_3 - 6.1e-45 152.2 0.0 1.1e-44 151.3 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.18 001199519.1_23525001_3 - 1.6e-43 147.3 0.2 3.4e-43 146.2 0.2 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.17 001199519.1_23525001_3 - 0.076 11.7 0.2 0.16 10.6 0.2 1.4 1 1 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) fn3 PF00041.19 001079719.3_23529001_3 - 0.0012 19.0 0.0 0.002 18.3 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain AKAP7_RIRII_bdg PF10470.7 001145193.1_23523001_2 - 0.00049 20.0 3.6 0.0007 19.5 3.6 1.2 1 0 0 1 1 1 1 PKA-RI-RII subunit binding domain of A-kinase anchor protein zf-C2H2 PF00096.24 001173522.1_23522001_1 - 7e-27 92.2 28.7 2.9e-06 27.3 1.1 5.3 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001173522.1_23522001_1 - 3.8e-22 76.9 27.5 7.6e-05 23.1 0.8 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001173522.1_23522001_1 - 3.7e-21 74.4 25.3 2.3e-07 30.8 0.4 5.5 5 0 0 5 5 5 5 Zinc-finger double domain zf-C2H2_6 PF13912.4 001173522.1_23522001_1 - 7.2e-14 51.2 31.4 0.0021 17.8 1.8 5.7 5 1 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001173522.1_23522001_1 - 3.9e-10 39.6 18.1 0.037 14.2 0.1 5.7 5 1 1 6 6 5 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001173522.1_23522001_1 - 1.7e-06 28.1 23.4 0.0021 18.2 0.2 5.3 5 0 0 5 5 5 2 Zinc-finger of C2H2 type XPA_N PF01286.16 001173522.1_23522001_1 - 7.6e-05 22.5 16.1 0.74 9.8 2.2 5.2 5 0 0 5 5 5 2 XPA protein N-terminal zf-C2H2_11 PF16622.3 001173522.1_23522001_1 - 8.6e-05 22.1 24.2 0.45 10.2 2.6 5.3 5 0 0 5 5 5 2 zinc-finger C2H2-type ADK_lid PF05191.12 001173522.1_23522001_1 - 0.00012 21.9 7.4 0.048 13.6 0.7 3.8 2 2 1 3 3 3 2 Adenylate kinase, active site lid zf-Di19 PF05605.10 001173522.1_23522001_1 - 0.00056 20.0 21.6 0.0032 17.6 3.7 3.8 1 1 4 5 5 5 4 Drought induced 19 protein (Di19), zinc-binding DZR PF12773.5 001173522.1_23522001_1 - 0.00056 19.7 13.2 0.4 10.6 6.1 3.3 2 1 0 2 2 2 2 Double zinc ribbon Zn-ribbon_8 PF09723.8 001173522.1_23522001_1 - 0.00089 19.2 17.9 0.56 10.2 0.2 4.4 3 2 1 4 4 4 1 Zinc ribbon domain HypA PF01155.17 001173522.1_23522001_1 - 0.0075 16.1 13.2 0.22 11.4 1.0 3.3 1 1 2 3 3 3 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.3 001173522.1_23522001_1 - 0.0089 16.6 13.9 0.036 14.7 1.0 2.9 2 1 0 2 2 2 1 zinc-ribbon family zf-C2H2_2 PF12756.5 001173522.1_23522001_1 - 0.057 13.6 21.7 1.3 9.3 1.2 4.6 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) C1_4 PF07975.10 001173522.1_23522001_1 - 0.1 12.8 15.0 0.62 10.2 2.6 3.5 2 1 1 3 3 3 0 TFIIH C1-like domain DUF2256 PF10013.7 001173522.1_23522001_1 - 0.12 12.4 10.6 29 4.7 0.0 5.0 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2256) DUF2310 PF10071.7 001173522.1_23522001_1 - 0.34 10.0 9.6 0.3 10.2 0.1 3.1 2 1 1 3 3 3 0 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310) PyrI_C PF02748.13 001173522.1_23522001_1 - 0.37 10.6 5.2 6.5 6.6 0.2 3.5 4 0 0 4 4 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zinc-ribbons_6 PF07191.10 001173522.1_23522001_1 - 0.37 10.7 15.8 3.6 7.5 3.1 3.5 1 1 1 2 2 2 0 zinc-ribbons FYVE PF01363.19 001173522.1_23522001_1 - 0.38 10.8 25.4 0.47 10.5 3.4 3.8 1 1 1 2 2 2 0 FYVE zinc finger zf-C2HC_2 PF13913.4 001173522.1_23522001_1 - 0.44 10.4 22.3 6.1 6.7 0.4 5.4 5 0 0 5 5 5 0 zinc-finger of a C2HC-type zf-LYAR PF08790.9 001173522.1_23522001_1 - 0.5 10.2 9.6 10 6.0 0.2 4.3 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger CpXC PF14353.4 001173522.1_23522001_1 - 0.63 10.0 16.7 2 8.3 0.2 4.6 1 1 2 4 4 4 0 CpXC protein zf-C2H2_9 PF16293.3 001173522.1_23522001_1 - 0.69 9.7 7.2 3.6 7.4 0.5 3.5 2 1 1 3 3 3 0 C2H2 type zinc-finger (1 copy) Ogr_Delta PF04606.10 001173522.1_23522001_1 - 0.78 9.6 16.6 2.3 8.2 0.8 3.4 3 0 0 3 3 3 0 Ogr/Delta-like zinc finger YhfH PF14149.4 001173522.1_23522001_1 - 0.96 9.4 15.2 26 4.7 0.1 5.0 5 0 0 5 5 5 0 YhfH-like protein TerY_C PF15616.4 001173522.1_23522001_1 - 0.99 9.4 8.9 3.8 7.5 2.7 3.0 1 1 1 3 3 3 0 TerY-C metal binding domain zf-ribbon_3 PF13248.4 001173522.1_23522001_1 - 1.1 8.7 17.9 4.5 6.7 0.2 4.7 5 0 0 5 5 5 0 zinc-ribbon domain zinc_ribbon_4 PF13717.4 001173522.1_23522001_1 - 1.2 9.0 20.2 5.9 6.8 0.2 5.1 4 1 0 4 4 4 0 zinc-ribbon domain DUF3268 PF11672.6 001173522.1_23522001_1 - 1.5 9.0 10.0 3.6 7.8 0.9 2.4 2 1 0 2 2 2 0 zinc-finger-containing domain Zn_Tnp_IS1595 PF12760.5 001173522.1_23522001_1 - 1.8 8.5 26.0 3.7 7.5 7.9 4.1 1 1 3 4 4 4 0 Transposase zinc-ribbon domain DUF1610 PF07754.9 001173522.1_23522001_1 - 1.9 8.4 9.3 1.5 8.8 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1610) Cys_rich_CPXG PF14255.4 001173522.1_23522001_1 - 2.4 8.0 6.1 19 5.1 0.1 3.7 3 1 0 3 3 3 0 Cysteine-rich CPXCG SprT-like PF10263.7 001173522.1_23522001_1 - 2.6 7.7 20.5 1.6e+04 -4.9 20.4 2.9 1 1 0 1 1 0 0 SprT-like family zf-C2HE PF16278.3 001173522.1_23522001_1 - 3.7 8.0 19.2 1.1 9.7 0.6 4.2 2 1 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf-FPG_IleRS PF06827.12 001173522.1_23522001_1 - 4.5 7.1 12.6 20 5.0 0.2 4.7 5 0 0 5 5 5 0 Zinc finger found in FPG and IleRS FOXP-CC PF16159.3 001173522.1_23522001_1 - 8 7.0 8.9 8.1 7.0 0.2 2.7 2 1 1 3 3 3 0 FOXP coiled-coil domain G-gamma PF00631.20 001097528.1_23525001_1 - 2e-18 66.0 0.0 5.3e-18 64.6 0.0 1.8 1 0 0 1 1 1 1 GGL domain Transglut_N PF00868.18 001006368.1_23525001_1 - 1.6e-32 112.2 0.0 5.7e-32 110.4 0.0 2.0 2 0 0 2 2 2 1 Transglutaminase family Transglut_C PF00927.20 001006368.1_23525001_1 - 2.5e-20 72.4 0.5 8.6e-13 48.2 0.1 2.5 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.17 001006368.1_23525001_1 - 6e-16 58.8 0.1 1.1e-15 57.9 0.1 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily APS-reductase_C PF12139.6 001006368.1_23525001_1 - 0.044 13.9 0.3 0.7 10.0 0.1 2.8 2 1 0 2 2 2 0 Adenosine-5'-phosphosulfate reductase beta subunit HSP70 PF00012.18 001012576.1_23527001_1 - 6.4e-189 628.9 8.2 8.9e-180 598.7 0.1 2.7 2 1 1 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.11 001012576.1_23527001_1 - 4.8e-08 32.1 0.0 8.5e-08 31.2 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Roughex PF06020.9 001012576.1_23527001_1 - 0.4 9.6 4.8 0.69 8.8 4.8 1.3 1 0 0 1 1 1 0 Drosophila roughex protein PCNP PF15473.4 001012576.1_23527001_1 - 8.3 7.0 11.0 11 6.6 5.2 2.5 2 0 0 2 2 2 0 PEST, proteolytic signal-containing nuclear protein family V-SNARE_C PF12352.6 001030652.1_23529001_3 - 0.00028 21.0 0.9 0.00073 19.6 0.9 1.7 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus DUF5082 PF16888.3 001030652.1_23529001_3 - 0.0011 19.2 2.5 0.0011 19.2 2.5 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5082) KxDL PF10241.7 001030652.1_23529001_3 - 0.031 14.4 1.9 0.35 11.1 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein MAP70 PF07058.9 001030652.1_23529001_3 - 0.066 11.8 8.1 0.096 11.3 8.1 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 DUF745 PF05335.11 001030652.1_23529001_3 - 0.1 12.2 1.3 0.23 11.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF745) IncA PF04156.12 001030652.1_23529001_3 - 0.39 10.3 8.6 3.4 7.3 7.8 2.3 1 1 0 1 1 1 0 IncA protein TPT PF03151.14 001199651.1_23525001_1 - 1.9e-23 83.1 12.5 2.4e-23 82.8 12.5 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.18 001199651.1_23525001_1 - 2e-07 31.1 30.3 8.5e-05 22.6 10.0 2.4 2 0 0 2 2 2 2 EamA-like transporter family MOSC_N PF03476.14 001282381.1_23529001_1 - 2.2e-37 127.4 0.0 3.5e-37 126.8 0.0 1.3 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.15 001282381.1_23529001_1 - 5.1e-32 110.5 0.0 7.8e-32 109.9 0.0 1.3 1 0 0 1 1 1 1 MOSC domain SRP14 PF02290.13 001006478.2_23523001_2 - 2.8e-25 88.4 0.1 4.8e-25 87.6 0.1 1.4 1 0 0 1 1 1 1 Signal recognition particle 14kD protein EMP24_GP25L PF01105.22 001007956.1_23527001_2 - 1.6e-46 158.4 0.3 3e-46 157.5 0.3 1.5 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD F-box-like PF12937.5 001270995.1_23527001_1 - 5.7e-12 45.2 1.0 2.5e-11 43.1 1.0 2.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001270995.1_23527001_1 - 3e-09 36.4 1.3 3e-09 36.4 1.3 3.0 2 0 0 2 2 2 1 F-box domain Na_H_Exchanger PF00999.19 001031305.2_23526001_1 - 3e-85 286.2 28.7 6.3e-85 285.1 28.7 1.5 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family Ig_4 PF16680.3 205512.1_23522001_1 - 1.4e-24 86.1 0.8 2.7e-24 85.2 0.8 1.5 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.3 205512.1_23522001_1 - 2.4e-10 40.5 1.1 3.9e-10 39.9 1.1 1.3 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain ITAM PF02189.13 205512.1_23522001_1 - 1.5e-06 28.2 1.8 3e-06 27.2 1.8 1.6 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif DAP10 PF07213.9 205512.1_23522001_1 - 0.027 14.3 0.2 0.064 13.1 0.2 1.6 1 0 0 1 1 1 0 DAP10 membrane protein Ig_2 PF13895.4 205512.1_23522001_1 - 0.055 13.7 0.1 0.11 12.7 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Ifi-6-16 PF06140.11 001001296.5_23521001_3 - 4.5e-22 77.6 25.9 2.1e-11 43.4 8.9 2.1 1 1 1 2 2 2 2 Interferon-induced 6-16 family UbiA PF01040.16 001030700.1_23526001_1 - 2.1e-54 184.4 12.0 2.1e-54 184.4 12.0 1.4 2 0 0 2 2 2 1 UbiA prenyltransferase family Serpin PF00079.18 001083920.1_23525001_3 - 1.5e-109 366.6 0.0 1.8e-109 366.3 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RNA_pol_A_bac PF01000.24 001293302.1_23524001_3 - 6.5e-40 135.9 0.0 1.1e-39 135.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.22 001293302.1_23524001_3 - 8.2e-15 53.9 0.0 1.3e-14 53.3 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DNA_ligase_A_M PF01068.19 001006215.2_23527001_2 - 2.2e-61 206.9 0.0 3.7e-61 206.2 0.0 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.12 001006215.2_23527001_2 - 9.4e-33 113.8 0.2 9.4e-33 113.8 0.2 2.2 3 0 0 3 3 3 1 DNA ligase N terminus LIG3_BRCT PF16759.3 001006215.2_23527001_2 - 8.3e-28 96.4 0.0 1.9e-27 95.2 0.0 1.7 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain zf-PARP PF00645.16 001006215.2_23527001_2 - 8.9e-23 80.8 0.4 2.8e-22 79.2 0.4 1.9 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region DNA_ligase_A_C PF04679.13 001006215.2_23527001_2 - 6.9e-18 64.9 0.0 2e-17 63.5 0.0 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT_2 PF16589.3 001006215.2_23527001_2 - 2.8e-07 30.7 0.0 8.3e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.8 001006215.2_23527001_2 - 9.8e-05 22.6 0.0 0.00017 21.8 0.0 1.4 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.17 001006215.2_23527001_2 - 0.082 12.6 0.2 0.18 11.4 0.2 1.6 1 1 0 1 1 1 0 mRNA capping enzyme, catalytic domain Thioredoxin_7 PF13899.4 001282295.1_23523001_1 - 6e-17 61.5 0.0 1.1e-16 60.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.18 001282295.1_23523001_1 - 1.5e-05 24.8 0.0 2.6e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.4 001282295.1_23523001_1 - 0.0049 17.2 0.0 0.0078 16.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredox_DsbH PF03190.13 001282295.1_23523001_1 - 0.034 14.0 0.0 0.059 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Thioredoxin_9 PF14595.4 001282295.1_23523001_1 - 0.059 13.0 0.0 0.097 12.3 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin DP PF08781.8 001184713.1_23529001_1 - 2.9e-60 202.0 2.8 4.7e-60 201.3 2.8 1.3 1 0 0 1 1 1 1 Transcription factor DP E2F_TDP PF02319.18 001184713.1_23529001_1 - 4.5e-26 90.5 0.2 9e-26 89.6 0.2 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain Ig_3 PF13927.4 204502.2_23526001_2 - 8.9e-28 96.6 0.1 4.4e-17 62.3 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 204502.2_23526001_2 - 3.4e-25 87.8 0.0 1.3e-15 57.0 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.4 204502.2_23526001_2 - 1.9e-16 60.0 0.0 1.1e-08 35.1 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 204502.2_23526001_2 - 1.6e-14 53.7 0.0 1.4e-07 31.4 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain EF-hand_5 PF13202.4 204502.2_23526001_2 - 3.1e-09 35.8 0.1 0.00012 21.3 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.30 204502.2_23526001_2 - 6.3e-09 34.6 0.0 1.7e-05 23.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 204502.2_23526001_2 - 1.6e-08 33.7 0.8 9.1e-05 22.0 0.2 2.8 2 0 0 2 2 2 2 EF-hand domain Kazal_2 PF07648.13 204502.2_23526001_2 - 1.9e-07 31.0 2.5 5e-07 29.7 2.5 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain EF-hand_7 PF13499.4 204502.2_23526001_2 - 7e-07 29.5 2.1 1.5e-06 28.5 2.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair V-set PF07686.15 204502.2_23526001_2 - 4.4e-06 26.7 2.4 0.37 10.8 0.1 4.1 3 1 1 4 4 3 2 Immunoglobulin V-set domain Kazal_1 PF00050.19 204502.2_23526001_2 - 1.3e-05 25.0 7.7 4e-05 23.4 7.7 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain EF-hand_8 PF13833.4 204502.2_23526001_2 - 0.00025 20.6 0.0 0.017 14.7 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair C2-set_2 PF08205.10 204502.2_23526001_2 - 0.00053 19.9 0.0 0.05 13.6 0.0 3.1 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 204502.2_23526001_2 - 0.0019 18.5 0.0 0.15 12.4 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin C1-set domain SPARC_Ca_bdg PF10591.7 204502.2_23526001_2 - 0.0094 16.1 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Cytochrom_D1 PF02239.14 204502.2_23526001_2 - 0.021 13.3 0.2 0.15 10.4 0.1 2.2 2 1 1 3 3 3 0 Cytochrome D1 heme domain EF-hand_4 PF12763.5 204502.2_23526001_2 - 0.13 12.1 0.1 0.3 10.9 0.1 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Complex1_LYR PF05347.13 001302181.1_23522001_1 - 2.5e-14 52.9 0.1 4e-14 52.3 0.1 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 001302181.1_23522001_1 - 9.4e-07 29.4 1.4 1.4e-06 28.8 1.4 1.3 1 0 0 1 1 1 1 Complex1_LYR-like TFIIS_M PF07500.12 001006387.1_23524001_2 - 3.2e-39 133.6 2.9 7.3e-39 132.5 2.9 1.6 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.16 001006387.1_23524001_2 - 9e-19 66.9 8.0 1.9e-18 65.9 8.0 1.6 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.9 001006387.1_23524001_2 - 2.3e-15 56.2 2.3 5.4e-15 55.0 2.3 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Ku_C PF03730.12 001006387.1_23524001_2 - 0.48 11.0 4.4 0.27 11.8 1.4 2.1 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm Alpha_kinase PF02816.16 001177555.1_23529001_2 - 1.6e-40 139.2 0.0 5.7e-40 137.4 0.0 1.9 1 0 0 1 1 1 1 Alpha-kinase family TRPM_tetra PF16519.3 001177555.1_23529001_2 - 1.2e-26 92.4 1.2 2.3e-26 91.5 1.2 1.5 1 0 0 1 1 1 1 Tetramerisation domain of TRPM Crystall PF00030.17 001170527.2_23522001_3 - 9e-61 201.9 0.7 1.4e-29 102.0 0.1 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 001170527.2_23522001_3 - 0.00016 21.4 2.4 0.014 15.1 0.3 3.0 2 1 0 2 2 2 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 001170527.2_23522001_3 - 0.00023 21.1 0.3 2.9 8.0 0.1 3.2 2 1 1 3 3 3 3 Beta/Gamma crystallin PMR5N PF14416.4 001170527.2_23522001_3 - 0.035 14.3 0.1 4.7 7.4 0.0 2.7 2 0 0 2 2 2 0 PMR5 N terminal Domain SSF PF00474.15 001001763.1_23524001_1 - 4.2e-33 114.7 29.2 5.9e-33 114.2 29.2 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family Phage_holin_Dp1 PF16938.3 001001763.1_23524001_1 - 9 6.6 11.2 3 8.1 1.6 3.4 3 0 0 3 3 3 0 Putative phage holin Dp-1 Glyco_transf_29 PF00777.16 001277494.1_23525001_3 - 5.3e-36 124.2 0.1 7.3e-36 123.8 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) AIF_C PF14721.4 001007490.1_23524001_1 - 1.8e-58 196.4 0.0 3.2e-58 195.6 0.0 1.4 1 0 0 1 1 1 1 Apoptosis-inducing factor, mitochondrion-associated, C-term Pyr_redox_2 PF07992.12 001007490.1_23524001_1 - 4.1e-44 150.9 0.0 7.4e-44 150.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.25 001007490.1_23524001_1 - 1.8e-13 50.7 0.3 5.1e-12 46.0 0.0 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase AIF-MLS PF14962.4 001007490.1_23524001_1 - 2.3e-11 43.9 0.2 2.3e-11 43.9 0.2 1.8 2 0 0 2 2 2 1 Mitochondria Localisation Sequence Pyr_redox_3 PF13738.4 001007490.1_23524001_1 - 3.2e-07 29.7 0.0 5.9e-06 25.6 0.0 2.5 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.4 001007490.1_23524001_1 - 7.9e-06 25.8 1.6 0.41 10.5 0.0 4.4 3 1 1 4 4 4 2 FAD-NAD(P)-binding Amino_oxidase PF01593.22 001007490.1_23524001_1 - 4.7e-05 22.7 0.1 0.009 15.2 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase HI0933_like PF03486.12 001007490.1_23524001_1 - 0.00065 18.4 0.2 0.33 9.4 0.0 3.1 3 0 0 3 3 3 1 HI0933-like protein DAO PF01266.22 001007490.1_23524001_1 - 0.0022 17.5 1.1 7 6.0 0.0 4.1 4 0 0 4 4 4 1 FAD dependent oxidoreductase K_oxygenase PF13434.4 001007490.1_23524001_1 - 0.0061 15.6 0.1 0.033 13.2 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.4 001007490.1_23524001_1 - 0.012 15.7 0.3 8.8 6.5 0.1 3.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain PYNP_C PF07831.11 001007490.1_23524001_1 - 0.058 12.9 0.1 0.4 10.2 0.0 2.1 2 0 0 2 2 2 0 Pyrimidine nucleoside phosphorylase C-terminal domain FAD_oxidored PF12831.5 001007490.1_23524001_1 - 0.059 12.6 0.6 0.55 9.4 0.2 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase Trp_halogenase PF04820.12 001007490.1_23524001_1 - 0.081 11.6 0.1 19 3.8 0.0 3.1 3 0 0 3 3 3 0 Tryptophan halogenase Bromodomain PF00439.23 001130739.1_23529001_3 - 8.5e-21 73.7 0.2 1.5e-20 72.9 0.2 1.4 1 0 0 1 1 1 1 Bromodomain WSD PF15613.4 001130739.1_23529001_3 - 0.0059 17.0 0.4 0.0059 17.0 0.4 2.4 2 0 0 2 2 2 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.15 001130739.1_23529001_3 - 0.011 15.9 0.4 0.022 14.9 0.4 1.4 1 0 0 1 1 1 0 DDT domain Integrin_alpha2 PF08441.10 001012858.1_23529001_1 - 2.5e-89 300.2 0.0 3.9e-89 299.5 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 001012858.1_23529001_1 - 3.7e-23 81.2 19.8 1.4e-10 41.0 0.0 5.0 5 0 0 5 5 5 3 FG-GAP repeat VCBS PF13517.4 001012858.1_23529001_1 - 7e-11 42.4 15.4 1.8e-08 34.7 2.9 3.1 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.18 001012858.1_23529001_1 - 0.0017 18.1 0.2 0.0048 16.7 0.2 1.8 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region FG-GAP_2 PF14312.4 001012858.1_23529001_1 - 0.0084 16.2 1.2 0.0084 16.2 1.2 4.8 5 0 0 5 5 5 1 FG-GAP repeat DEAD PF00270.27 001030938.1_23526001_1 - 2.3e-47 160.9 0.0 4.6e-47 159.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001030938.1_23526001_1 - 7.9e-28 96.9 0.1 2.2e-27 95.5 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 001030938.1_23526001_1 - 3.5e-05 23.7 0.0 0.00012 22.0 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 001030938.1_23526001_1 - 0.059 13.6 0.0 1.3 9.2 0.0 2.3 1 1 0 2 2 2 0 AAA domain Ank_2 PF12796.5 001030851.1_23527001_2 - 1.6e-31 108.6 5.4 7.6e-17 61.6 2.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001030851.1_23527001_2 - 1.9e-29 101.5 6.6 1.3e-13 51.0 0.4 5.7 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.28 001030851.1_23527001_2 - 2.9e-25 87.4 16.9 2.9e-08 33.7 0.4 5.3 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.4 001030851.1_23527001_2 - 3.8e-25 87.4 12.8 2e-11 43.7 1.6 4.3 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 001030851.1_23527001_2 - 3.9e-19 66.6 8.1 0.00033 20.7 0.2 5.5 5 0 0 5 5 5 4 Ankyrin repeat DUF4770 PF15994.3 001030851.1_23527001_2 - 0.054 13.6 0.8 0.096 12.8 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) APG6 PF04111.10 001030851.1_23527001_2 - 0.16 11.2 4.7 0.28 10.4 4.7 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4337 PF14235.4 001030851.1_23527001_2 - 0.26 11.2 4.7 0.5 10.3 4.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) RRM_1 PF00076.20 205024.1_23523001_1 - 5.5e-33 112.5 0.0 3.3e-16 58.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.10 205024.1_23523001_1 - 0.0009 19.3 0.0 0.9 9.7 0.0 2.3 2 0 0 2 2 2 2 BRCA1-associated protein 2 PRELI PF04707.12 001030866.1_23526001_1 - 3.5e-54 182.8 0.1 5.3e-54 182.1 0.1 1.3 1 0 0 1 1 1 1 PRELI-like family WD40 PF00400.30 001012793.1_23526001_1 - 3.2e-15 56.1 8.8 0.062 14.1 0.0 6.9 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001012793.1_23526001_1 - 8.7e-06 25.8 0.2 0.27 11.4 0.0 3.6 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DSPn PF14671.4 001177736.1_23524001_1 - 1.2e-63 213.6 4.1 2.2e-63 212.7 2.6 2.2 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.18 001177736.1_23524001_1 - 5.6e-15 55.2 0.1 2.5e-14 53.1 0.0 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 001177736.1_23524001_1 - 6.6e-06 26.2 0.0 1.4e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.25 001177736.1_23524001_1 - 2.6e-05 23.8 0.0 4.3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.11 001177736.1_23524001_1 - 0.0085 15.6 0.0 0.021 14.3 0.0 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.4 001177736.1_23524001_1 - 0.011 15.6 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Patatin PF01734.20 001113291.1_23524001_1 - 1e-14 55.1 3.2 1.5e-13 51.3 3.2 2.2 1 1 0 1 1 1 1 Patatin-like phospholipase Peptidase_M14 PF00246.22 001277254.1_23524001_2 - 5e-79 266.0 0.0 6.3e-79 265.6 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.4 001277254.1_23524001_2 - 1.3e-15 57.3 0.7 2.4e-15 56.4 0.7 1.5 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.4 001277254.1_23524001_2 - 2e-10 40.4 0.1 3.3e-10 39.7 0.1 1.3 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.12 001277254.1_23524001_2 - 0.052 12.5 0.1 0.12 11.3 0.1 1.6 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family DUF2817 PF10994.6 001277254.1_23524001_2 - 0.11 11.6 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) Zona_pellucida PF00100.21 204339.1_23527001_2 - 7.7e-38 130.6 1.1 1.3e-37 129.8 1.1 1.4 1 0 0 1 1 1 1 Zona pellucida-like domain Nucleopor_Nup85 PF07575.11 001006426.2_23525001_1 - 2.7e-173 577.5 15.5 3.1e-173 577.3 15.5 1.0 1 0 0 1 1 1 1 Nup85 Nucleoporin MFS_1 PF07690.14 001031086.1_23527001_2 - 3.1e-57 194.0 32.4 1.7e-56 191.5 23.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TPD52 PF04201.13 001030858.1_23525001_2 - 2.1e-66 222.4 5.6 8.9e-36 122.8 0.3 2.2 1 1 1 2 2 2 2 Tumour protein D52 family Glyco_hydro_36 PF17167.2 001030858.1_23525001_2 - 0.078 11.5 0.1 0.11 11.0 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase 36 superfamily, catalytic domain DUF1192 PF06698.9 001030858.1_23525001_2 - 0.097 12.6 1.2 0.19 11.7 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) P2X_receptor PF00864.17 204291.1_23524001_3 - 6.5e-174 578.1 1.9 7.8e-174 577.8 1.9 1.0 1 0 0 1 1 1 1 ATP P2X receptor HLH PF00010.24 204797.1_23523001_2 - 4.3e-17 61.7 0.3 4.3e-17 61.7 0.3 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain PI3Ka PF00613.18 001031311.1_23529001_3 - 6.9e-62 208.0 1.2 1.3e-61 207.1 1.2 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.25 001031311.1_23529001_3 - 1e-59 202.2 0.0 2e-59 201.3 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_p85B PF02192.14 001031311.1_23529001_3 - 1e-32 111.6 0.1 2.6e-32 110.2 0.1 1.8 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain PI3K_rbd PF00794.16 001031311.1_23529001_3 - 1.4e-30 105.5 0.1 2.8e-30 104.5 0.1 1.6 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.22 001031311.1_23529001_3 - 1.7e-19 70.1 0.0 3.1e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 RWD PF05773.20 001031311.1_23529001_3 - 0.01 16.0 0.2 2.2 8.5 0.1 2.7 2 0 0 2 2 2 0 RWD domain DUF4135 PF13575.4 001031311.1_23529001_3 - 0.055 12.7 0.0 0.09 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Aldo_ket_red PF00248.19 001243590.1_23525001_1 - 2.5e-51 174.5 0.0 4.5e-51 173.6 0.0 1.4 2 0 0 2 2 2 1 Aldo/keto reductase family Kelch_1 PF01344.23 001031304.2_23529001_3 - 2.2e-37 126.2 16.9 1.5e-10 40.3 0.2 7.1 7 0 0 7 7 7 6 Kelch motif BACK PF07707.13 001031304.2_23529001_3 - 3.9e-32 110.3 0.7 7.3e-32 109.4 0.7 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 001031304.2_23529001_3 - 5.3e-28 97.3 0.8 1.2e-27 96.2 0.8 1.6 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.4 001031304.2_23529001_3 - 2.5e-24 84.6 7.9 0.00049 20.2 0.0 6.5 4 1 2 6 6 6 6 Kelch motif Kelch_3 PF13415.4 001031304.2_23529001_3 - 3.9e-24 84.2 2.3 0.00022 21.3 0.0 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.4 001031304.2_23529001_3 - 4e-16 58.6 1.8 0.0009 19.0 0.0 6.4 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.13 001031304.2_23529001_3 - 1.6e-13 49.9 8.6 0.018 14.9 0.0 6.2 7 0 0 7 7 7 4 Kelch motif Kelch_5 PF13854.4 001031304.2_23529001_3 - 0.00023 20.9 1.2 0.68 9.8 0.0 4.5 4 0 0 4 4 4 1 Kelch motif DUF3342 PF11822.6 001031304.2_23529001_3 - 0.023 14.7 0.2 0.07 13.2 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Trypsin PF00089.24 001277636.1_23522001_1 - 1.5e-70 237.4 0.9 1.7e-70 237.2 0.9 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001277636.1_23522001_1 - 1.1e-06 29.5 0.1 1.7e-06 28.8 0.1 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001277636.1_23522001_1 - 2.6e-05 24.4 0.0 5.6e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) DUF316 PF03761.13 001277636.1_23522001_1 - 0.005 16.3 0.0 0.094 12.1 0.0 2.3 2 1 0 2 2 2 1 Chymotrypsin family Peptidase-S1 VHS PF00790.17 001031108.1_23529001_1 - 9.4e-48 161.5 1.0 2.7e-47 160.0 0.0 2.0 2 0 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.18 001031108.1_23529001_1 - 6.1e-28 97.2 0.0 1.1e-27 96.4 0.0 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain GAT PF03127.12 001031108.1_23529001_1 - 6.5e-19 67.9 2.8 6.5e-19 67.9 2.8 2.3 2 0 0 2 2 2 1 GAT domain SesA PF17107.3 001031108.1_23529001_1 - 0.051 13.6 0.7 0.1 12.6 0.7 1.5 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases HBM PF16591.3 001031108.1_23529001_1 - 0.054 12.8 1.7 0.087 12.1 1.7 1.2 1 0 0 1 1 1 0 Helical bimodular sensor domain zf-C4H2 PF10146.7 001031108.1_23529001_1 - 0.17 12.0 3.9 1.6 8.8 0.6 2.3 2 0 0 2 2 2 0 Zinc finger-containing protein 7tm_1 PF00001.19 001045835.1_23523001_1 - 2.7e-50 171.0 26.9 8.7e-50 169.3 26.9 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001045835.1_23523001_1 - 2.4e-10 40.1 26.4 3.1e-10 39.7 26.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx PspC PF04024.10 001045835.1_23523001_1 - 0.21 11.3 0.1 0.21 11.3 0.1 2.6 2 1 0 2 2 2 0 PspC domain 7TM_GPCR_Srx PF10328.7 001045835.1_23523001_1 - 1.4 8.0 31.4 0.0063 15.7 18.2 2.2 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx PBC PF03792.11 001030678.1_23526001_1 - 9.3e-94 312.4 0.2 1.4e-93 311.8 0.2 1.3 1 0 0 1 1 1 1 PBC domain Homeobox PF00046.27 001030678.1_23526001_1 - 8.7e-19 67.0 1.2 2e-18 65.8 1.2 1.7 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001030678.1_23526001_1 - 2.7e-15 55.8 0.0 1.2e-14 53.7 0.0 2.1 2 0 0 2 2 2 1 Homeobox KN domain YdaS_antitoxin PF15943.3 001030678.1_23526001_1 - 0.064 13.0 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Bap31 PF05529.10 001097645.1_23524001_3 - 2.1e-68 229.7 5.6 2.9e-68 229.3 5.6 1.2 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like Sec34 PF04136.13 001097645.1_23524001_3 - 0.0021 17.8 5.4 0.0096 15.7 0.8 2.3 2 0 0 2 2 2 1 Sec34-like family MAD PF05557.11 001097645.1_23524001_3 - 0.0085 14.4 14.1 0.011 14.0 14.1 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein MscS_porin PF12795.5 001097645.1_23524001_3 - 0.012 15.0 11.0 0.017 14.5 11.0 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF4407 PF14362.4 001097645.1_23524001_3 - 0.026 13.8 4.8 0.039 13.2 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cluap1 PF10234.7 001097645.1_23524001_3 - 0.036 13.3 6.5 0.053 12.8 6.5 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 Spc7 PF08317.9 001097645.1_23524001_3 - 0.13 11.0 13.9 0.19 10.4 13.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein HOOK PF05622.10 001097645.1_23524001_3 - 0.19 9.7 11.5 0.27 9.2 11.5 1.1 1 0 0 1 1 1 0 HOOK protein MPS2 PF17060.3 001097645.1_23524001_3 - 0.24 10.5 5.6 0.4 9.8 5.6 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 APG6 PF04111.10 001097645.1_23524001_3 - 0.26 10.5 14.9 0.38 10.0 14.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Fzo_mitofusin PF04799.11 001097645.1_23524001_3 - 0.29 10.5 3.2 0.28 10.6 1.9 1.5 1 1 0 1 1 1 0 fzo-like conserved region Syntaxin_2 PF14523.4 001097645.1_23524001_3 - 0.35 11.1 4.3 0.73 10.1 4.3 1.5 1 1 0 1 1 1 0 Syntaxin-like protein DUF1664 PF07889.10 001097645.1_23524001_3 - 0.47 10.3 2.2 0.86 9.5 1.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) TBPIP PF07106.11 001097645.1_23524001_3 - 0.5 10.0 7.6 0.88 9.2 7.6 1.3 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF972 PF06156.11 001097645.1_23524001_3 - 0.51 10.9 12.7 3.9 8.0 2.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Fez1 PF06818.13 001097645.1_23524001_3 - 0.54 10.5 13.1 0.78 10.0 13.1 1.2 1 0 0 1 1 1 0 Fez1 FliJ PF02050.14 001097645.1_23524001_3 - 0.57 10.3 11.7 1 9.5 11.7 1.3 1 0 0 1 1 1 0 Flagellar FliJ protein Mod_r PF07200.11 001097645.1_23524001_3 - 0.77 9.7 11.1 1.6 8.7 11.1 1.5 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein End3 PF12761.5 001097645.1_23524001_3 - 1 9.4 11.3 1.6 8.7 11.3 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Cnn_1N PF07989.9 001097645.1_23524001_3 - 2.1 8.4 7.9 0.48 10.5 3.0 2.1 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 PspA_IM30 PF04012.10 001097645.1_23524001_3 - 2.2 7.7 17.0 4.5 6.6 17.0 1.5 1 1 0 1 1 1 0 PspA/IM30 family bZIP_1 PF00170.19 001097645.1_23524001_3 - 2.3 8.2 10.9 3.2 7.8 0.3 3.4 2 1 1 3 3 2 0 bZIP transcription factor TMF_TATA_bd PF12325.6 001097645.1_23524001_3 - 2.9 8.0 13.6 0.26 11.4 5.0 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding CREPT PF16566.3 001097645.1_23524001_3 - 3.1 7.8 7.3 5.7 7.0 7.3 1.4 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DUF3450 PF11932.6 001097645.1_23524001_3 - 4 6.5 10.0 7.2 5.7 9.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) ADIP PF11559.6 001097645.1_23524001_3 - 4.4 7.2 14.5 25 4.8 13.2 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding ABC_tran_CTD PF16326.3 001097645.1_23524001_3 - 4.7 7.4 14.6 0.27 11.4 3.2 2.3 1 1 1 2 2 2 0 ABC transporter C-terminal domain CENP-H PF05837.10 001097645.1_23524001_3 - 4.7 7.5 15.1 2.1 8.6 4.3 2.2 1 1 1 2 2 2 0 Centromere protein H (CENP-H) BRE1 PF08647.9 001097645.1_23524001_3 - 6.2 6.8 13.2 0.51 10.3 6.9 2.0 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Uso1_p115_C PF04871.11 001097645.1_23524001_3 - 9.2 6.5 20.1 0.73 10.1 9.8 2.2 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DivIC PF04977.13 001097645.1_23524001_3 - 9.9 5.9 11.9 2.7 7.7 2.1 3.3 1 1 2 3 3 3 0 Septum formation initiator 2-oxoacid_dh PF00198.21 001012901.1_23524001_2 - 3.9e-62 209.6 0.0 5.2e-62 209.2 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.20 001012901.1_23524001_2 - 3.2e-22 78.0 0.5 5.1e-22 77.3 0.5 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.4 001012901.1_23524001_2 - 0.0021 17.7 0.0 0.005 16.5 0.0 1.7 1 0 0 1 1 1 1 Biotin-lipoyl like GCV_H PF01597.17 001012901.1_23524001_2 - 0.025 14.4 0.2 0.045 13.5 0.2 1.4 1 0 0 1 1 1 0 Glycine cleavage H-protein HlyD_D23 PF16576.3 001012901.1_23524001_2 - 0.093 11.8 0.0 0.49 9.4 0.0 1.9 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion SNAP PF14938.4 001199430.1_23527001_3 - 9.4e-110 366.3 21.7 1.2e-109 366.0 21.7 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.4 001199430.1_23527001_3 - 5.3e-06 26.5 14.3 0.0048 17.0 0.5 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.4 001199430.1_23527001_3 - 0.0021 17.8 4.3 0.28 11.2 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat Spatacsin_C PF14649.4 001199430.1_23527001_3 - 0.011 14.7 9.8 0.12 11.4 2.8 2.3 1 1 1 2 2 2 0 Spatacsin C-terminus TPR_2 PF07719.15 001199430.1_23527001_3 - 0.026 14.5 11.5 9.5 6.5 0.9 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.4 001199430.1_23527001_3 - 0.087 13.4 8.7 12 6.6 0.3 4.9 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.4 001199430.1_23527001_3 - 0.14 12.8 1.9 1.9 9.1 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.26 001199430.1_23527001_3 - 3.1 7.7 12.5 16 5.4 0.8 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.5 001199430.1_23527001_3 - 9.2 6.4 9.7 3.7 7.7 3.3 2.9 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Hormone_recep PF00104.28 001030855.1_23524001_1 - 5e-41 140.4 0.0 9.3e-41 139.6 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001030855.1_23524001_1 - 7.7e-30 103.0 18.4 7.7e-30 103.0 18.4 1.8 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Peptidase_C12 PF01088.19 204825.1_23522001_2 - 1e-65 221.3 0.0 1.5e-65 220.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Nab1 PF04902.10 204268.2_23524001_1 - 4.3e-66 222.6 0.2 7.3e-66 221.9 0.2 1.4 1 0 0 1 1 1 1 Conserved region in Nab1 NCD2 PF04905.11 204268.2_23524001_1 - 6.7e-65 217.7 0.5 1.2e-64 216.9 0.5 1.4 1 0 0 1 1 1 1 NAB conserved region 2 (NCD2) NCD1 PF04904.11 204268.2_23524001_1 - 8e-41 137.8 0.0 1.3e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 NAB conserved region 1 (NCD1) Pkinase PF00069.23 001199857.1_23522001_1 - 3.8e-79 265.6 0.0 4.3e-79 265.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001199857.1_23522001_1 - 9.4e-36 123.3 0.0 1.6e-35 122.5 0.0 1.3 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.4 001199857.1_23522001_1 - 0.0026 17.0 0.1 0.078 12.1 0.0 2.5 2 1 0 2 2 2 1 Kinase-like APH PF01636.21 001199857.1_23522001_1 - 0.0059 16.4 0.1 0.02 14.7 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Rad51 PF08423.9 001006489.1_23524001_2 - 3.1e-39 134.6 0.0 4.1e-39 134.2 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.19 001006489.1_23524001_2 - 9.9e-06 25.1 0.0 0.043 13.1 0.0 2.1 2 0 0 2 2 2 2 recA bacterial DNA recombination protein AAA_25 PF13481.4 001006489.1_23524001_2 - 7.8e-05 22.2 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.11 001006489.1_23524001_2 - 0.0002 20.7 0.0 0.00036 19.8 0.0 1.4 1 1 0 1 1 1 1 KaiC RNA_pol_A_CTD PF03118.13 001006489.1_23524001_2 - 0.0015 18.1 0.0 0.0028 17.2 0.0 1.3 1 0 0 1 1 1 1 Bacterial RNA polymerase, alpha chain C terminal domain TNF PF00229.16 204327.2_23528001_3 - 2.1e-09 37.2 0.0 6.7e-09 35.6 0.0 1.8 2 0 0 2 2 2 1 TNF(Tumour Necrosis Factor) family Yip1 PF04893.15 001198637.1_23524001_2 - 3e-09 36.7 16.2 4.6e-09 36.1 16.2 1.3 1 0 0 1 1 1 1 Yip1 domain CNH PF00780.20 001199443.1_23529001_1 - 1.2e-76 257.8 0.2 2.3e-76 256.9 0.2 1.5 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.23 001199443.1_23529001_1 - 2.8e-55 187.4 0.0 8.8e-55 185.8 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain KELK PF15796.3 001199443.1_23529001_1 - 5.3e-32 110.0 21.1 5.3e-32 110.0 21.1 7.5 5 2 2 7 7 6 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase Pkinase_Tyr PF07714.15 001199443.1_23529001_1 - 4e-29 101.6 0.0 1.1e-28 100.2 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase DMPK_coil PF08826.8 001199443.1_23529001_1 - 1.8e-25 88.7 11.5 1.8e-25 88.7 11.5 9.1 8 3 1 9 9 7 1 DMPK coiled coil domain like C1_1 PF00130.20 001199443.1_23529001_1 - 2.2e-11 43.3 8.1 2.2e-11 43.3 8.1 2.0 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.4 001199443.1_23529001_1 - 5.6e-07 29.0 0.0 1.6e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 Kinase-like Pkinase_C PF00433.22 001199443.1_23529001_1 - 0.00013 22.4 1.6 0.00013 22.4 1.6 2.1 2 0 0 2 2 1 1 Protein kinase C terminal domain PBD PF00786.26 001199443.1_23529001_1 - 0.018 15.3 0.4 0.092 13.0 0.1 2.5 2 0 0 2 2 2 0 P21-Rho-binding domain Seadorna_VP7 PF07387.9 001199443.1_23529001_1 - 0.07 12.0 0.3 0.16 10.8 0.3 1.5 1 0 0 1 1 1 0 Seadornavirus VP7 Reo_sigmaC PF04582.10 001199443.1_23529001_1 - 0.55 9.4 16.4 1.9 7.6 0.1 3.6 2 2 1 3 3 3 0 Reovirus sigma C capsid protein Pkinase PF00069.23 001031353.1_23526001_2 - 5.2e-69 232.4 0.0 2.3e-68 230.3 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 001031353.1_23526001_2 - 2.5e-26 92.4 0.0 4.1e-26 91.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.17 001031353.1_23526001_2 - 9.5e-18 64.4 4.5 2e-17 63.4 4.5 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain PH PF00169.27 001031353.1_23526001_2 - 1.2e-10 41.7 0.1 2.1e-10 40.9 0.1 1.4 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.4 001031353.1_23526001_2 - 0.026 13.7 0.0 0.041 13.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like bcl-2I13 PF12201.6 001278058.1_23523001_1 - 9.3e-06 25.5 0.0 1.3e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Bcl2-interacting killer, BH3-domain containing Cys_knot PF00007.20 001278086.1_23524001_2 - 2.9e-05 24.2 12.9 5.7e-05 23.2 12.9 1.4 1 0 0 1 1 1 1 Cystine-knot domain DAN PF03045.13 001278086.1_23524001_2 - 0.00039 20.3 10.6 0.00039 20.3 10.6 1.7 2 0 0 2 2 2 1 DAN domain VPS13_mid_rpt PF16910.3 001277836.1_23529001_2 - 4.3e-84 281.5 30.7 1.4e-73 247.1 1.7 7.1 6 2 0 6 6 6 3 Repeating coiled region of VPS13 VPS13 PF16908.3 001277836.1_23529001_2 - 9e-69 231.7 14.3 2.7e-64 217.1 4.1 4.9 4 0 0 4 4 4 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.3 001277836.1_23529001_2 - 1.8e-65 219.9 7.1 2.6e-62 209.6 0.3 3.1 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.5 001277836.1_23529001_2 - 1.6e-39 134.5 0.7 1.5e-37 128.1 0.2 3.5 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 SHR-BD PF06650.10 001277836.1_23529001_2 - 1.8e-39 135.6 3.8 4.1e-38 131.2 0.2 3.3 3 0 0 3 3 3 1 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.9 001277836.1_23529001_2 - 1.5e-14 53.9 0.1 3.3e-13 49.7 0.0 3.0 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain zf-DHHC PF01529.18 001030745.1_23529001_1 - 6.9e-35 119.9 20.9 6.9e-35 119.9 20.9 2.4 3 0 0 3 3 3 1 DHHC palmitoyltransferase Ank_2 PF12796.5 001030745.1_23529001_1 - 2.1e-30 105.0 1.1 5.9e-16 58.7 0.2 2.8 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001030745.1_23529001_1 - 7.2e-27 93.3 6.4 2.3e-08 34.3 0.0 4.0 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 001030745.1_23529001_1 - 2.8e-25 85.5 2.5 0.00018 21.6 0.1 7.0 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.4 001030745.1_23529001_1 - 6e-24 83.6 2.5 3.4e-06 27.1 0.2 5.4 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.28 001030745.1_23529001_1 - 2.2e-20 72.0 6.0 1.7e-05 24.9 0.4 6.1 6 0 0 6 6 6 4 Ankyrin repeat WD40 PF00400.30 001079495.2_23524001_3 - 1.1e-11 44.9 15.1 0.00023 21.8 0.5 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001079495.2_23524001_3 - 8.9e-11 41.8 0.7 0.043 14.0 0.0 3.6 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Rax2 PF12768.5 001079495.2_23524001_3 - 0.0013 18.3 0.2 0.27 10.7 0.0 2.4 2 1 0 2 2 2 2 Cortical protein marker for cell polarity Aminotran_5 PF00266.17 001030847.1_23527001_3 - 1.6e-91 306.9 0.0 2e-91 306.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.19 001030847.1_23527001_3 - 5.2e-09 35.7 0.0 8.3e-09 35.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.15 001030847.1_23527001_3 - 0.0036 16.5 0.0 0.0059 15.8 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family UDG PF03167.17 204189.1_23522001_1 - 3.6e-23 82.1 0.0 6.8e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily p450 PF00067.20 001005571.1_23524001_3 - 9.5e-44 149.8 0.1 4.2e-43 147.6 0.1 1.9 1 1 0 1 1 1 1 Cytochrome P450 Imm26 PF15428.4 001005571.1_23524001_3 - 0.023 14.8 0.0 0.13 12.3 0.0 2.2 1 1 1 2 2 2 0 Immunity protein 26 zf-H2C2_2 PF13465.4 204820.1_23523001_1 - 1e-23 82.5 30.9 6.4e-07 29.4 3.8 6.1 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.24 204820.1_23523001_1 - 4.6e-16 58.1 38.7 8.8e-06 25.8 0.4 6.6 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 204820.1_23523001_1 - 3.2e-11 42.9 39.6 0.00025 21.5 0.3 6.8 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 204820.1_23523001_1 - 0.0003 20.5 34.6 0.49 10.3 2.6 6.5 6 0 0 6 6 6 3 C2H2-type zinc finger zf-H2C2_5 PF13909.4 204820.1_23523001_1 - 0.0032 17.1 0.1 0.0032 17.1 0.1 5.9 6 0 0 6 6 6 2 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.3 204820.1_23523001_1 - 0.005 16.4 0.2 0.005 16.4 0.2 4.8 5 1 0 5 5 4 1 zinc-finger C2H2-type zf-MYND PF01753.16 204820.1_23523001_1 - 0.059 13.4 0.4 0.059 13.4 0.4 3.7 3 1 1 4 4 4 0 MYND finger GAGA PF09237.9 204820.1_23523001_1 - 0.068 12.9 4.0 0.12 12.1 0.1 3.2 2 1 0 3 3 3 0 GAGA factor zf-C2H2_jaz PF12171.6 204820.1_23523001_1 - 0.3 11.3 19.5 2.5 8.4 0.3 5.3 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 204820.1_23523001_1 - 1.4 9.1 8.8 0.3 11.3 0.3 2.8 2 1 0 2 2 2 0 zinc-finger-containing domain AKAP95 PF04988.10 204820.1_23523001_1 - 2.5 8.2 7.5 1.4 9.0 0.3 2.6 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) zf-C2HE PF16278.3 204820.1_23523001_1 - 2.5 8.5 21.4 5.3 7.5 2.4 4.9 3 1 2 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger CX9C PF16860.3 001302182.1_23521001_3 - 0.031 14.1 0.1 0.078 12.9 0.1 1.7 1 1 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, RBB1NT PF08169.9 001012902.2_23529001_2 - 2e-38 130.4 0.3 1.2e-37 128.0 0.3 2.5 1 0 0 1 1 1 1 RBB1NT (NUC162) domain ARID PF01388.19 001012902.2_23529001_2 - 1.3e-20 73.7 0.1 2.7e-20 72.7 0.1 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Tudor-knot PF11717.6 001012902.2_23529001_2 - 1.5e-13 50.3 1.9 4.5e-13 48.7 1.9 1.9 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain PWWP PF00855.15 001012902.2_23529001_2 - 0.0064 16.8 0.1 0.0064 16.8 0.1 4.3 4 1 0 4 4 4 2 PWWP domain IPK PF03770.14 204881.1_23525001_1 - 5e-42 143.9 0.0 9e-42 143.0 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase Dynein_light PF01221.16 001302156.1_23522001_3 - 5.1e-43 145.2 2.1 8.3e-43 144.5 2.1 1.3 1 0 0 1 1 1 1 Dynein light chain type 1 Collagen PF01391.16 001162399.2_23529001_1 - 1.7e-197 639.3 767.5 1.1e-09 37.8 21.4 27.6 5 4 21 26 26 26 26 Collagen triple helix repeat (20 copies) C4 PF01413.17 001162399.2_23529001_1 - 1.5e-82 273.1 3.3 6.4e-44 148.7 0.3 2.3 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen ATP_synt_H PF05493.11 001277388.1_23522001_1 - 7.1e-22 77.5 4.2 1.6e-21 76.4 4.2 1.6 1 0 0 1 1 1 1 ATP synthase subunit H Bcl-2 PF00452.17 204866.1_23522001_1 - 1e-22 80.5 0.0 1.6e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family ECH_1 PF00378.18 001277395.1_23523001_1 - 1.7e-92 309.1 2.1 2.2e-92 308.8 2.1 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 001277395.1_23523001_1 - 2.2e-34 119.3 4.8 8e-33 114.2 1.0 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Cofilin_ADF PF00241.18 001031214.1_23525001_3 - 3.9e-33 114.2 0.3 5.2e-33 113.8 0.3 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein CASP_C PF08172.10 001290201.1_23526001_3 - 3.3e-58 196.9 0.1 3.3e-58 196.9 0.1 5.2 2 2 2 4 4 4 1 CASP C terminal NPV_P10 PF05531.10 001290201.1_23526001_3 - 0.015 15.6 1.3 0.015 15.6 1.3 6.3 5 1 1 6 6 6 0 Nucleopolyhedrovirus P10 protein KASH_CCD PF14662.4 001290201.1_23526001_3 - 0.078 12.7 0.3 0.078 12.7 0.3 5.0 4 1 1 5 5 5 0 Coiled-coil region of CCDC155 or KASH YgbB PF02542.14 001290201.1_23526001_3 - 0.2 11.8 1.1 0.6 10.3 0.6 2.0 1 1 0 1 1 1 0 YgbB family Reo_sigmaC PF04582.10 001290201.1_23526001_3 - 0.35 10.1 24.0 8.8 5.5 6.2 4.9 3 1 2 5 5 5 0 Reovirus sigma C capsid protein CALCOCO1 PF07888.9 001290201.1_23526001_3 - 2.2 6.6 68.3 2.3 6.6 0.3 3.0 2 1 1 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like Collagen PF01391.16 204790.2_23529001_1 - 1.4e-166 540.3 703.5 1.6e-08 34.0 21.5 22.2 3 1 14 17 17 17 13 Collagen triple helix repeat (20 copies) COLFI PF01410.16 204790.2_23529001_1 - 3.9e-96 320.7 0.0 5.6e-96 320.2 0.0 1.2 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Laminin_G_2 PF02210.22 204790.2_23529001_1 - 0.00011 22.7 0.0 0.00019 21.9 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.4 204790.2_23529001_1 - 0.0039 17.2 0.0 0.0067 16.5 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.21 204790.2_23529001_1 - 0.068 13.3 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain ETRAMP PF09716.8 204790.2_23529001_1 - 1.4 8.9 4.7 3.2 7.7 0.4 2.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) UQ_con PF00179.24 001031153.1_23524001_3 - 1.1e-51 174.0 0.0 1.5e-51 173.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.20 001031153.1_23524001_3 - 0.16 12.1 0.0 0.28 11.3 0.0 1.3 1 0 0 1 1 1 0 RWD domain DEAD PF00270.27 001006293.1_23526001_1 - 2.5e-45 154.3 0.2 1.9e-44 151.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001006293.1_23526001_1 - 5.7e-29 100.6 3.0 3.3e-28 98.2 0.2 3.4 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.13 001006293.1_23526001_1 - 3.3e-06 27.1 0.0 3.3e-06 27.1 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.4 001006293.1_23526001_1 - 0.0041 17.3 1.9 0.045 13.9 1.9 2.7 1 1 0 1 1 1 1 AAA domain PRK PF00485.16 001006293.1_23526001_1 - 0.025 14.2 0.1 0.31 10.6 0.0 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family 7tm_1 PF00001.19 001083365.1_23523001_3 - 6.8e-22 77.8 0.6 7.7e-22 77.7 0.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001083365.1_23523001_3 - 3.4e-05 23.2 0.2 3.4e-05 23.2 0.2 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx STE3 PF02076.13 001083365.1_23523001_3 - 0.011 14.8 0.4 0.023 13.8 0.4 1.5 1 0 0 1 1 1 0 Pheromone A receptor 7TM_GPCR_Srbc PF10316.7 001083365.1_23523001_3 - 0.016 14.6 1.3 0.016 14.6 1.3 1.9 3 0 0 3 3 3 0 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srsx PF10320.7 001083365.1_23523001_3 - 0.15 11.3 5.4 0.4 9.9 5.4 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx Ion_trans PF00520.29 001293281.1_23529001_1 - 2.4e-256 845.5 105.5 7.5e-81 270.8 18.4 4.3 4 0 0 4 4 4 4 Ion transport protein Na_trans_cytopl PF11933.6 001293281.1_23529001_1 - 4.3e-82 274.9 10.2 8.6e-82 274.0 10.2 1.5 1 0 0 1 1 1 1 Cytoplasmic domain of voltage-gated Na+ ion channel Na_trans_assoc PF06512.11 001293281.1_23529001_1 - 5.4e-62 209.3 1.6 5.4e-62 209.3 1.6 3.7 3 0 0 3 3 3 1 Sodium ion transport-associated PKD_channel PF08016.10 001293281.1_23529001_1 - 3e-06 26.1 80.0 0.00018 20.2 0.2 9.3 6 4 4 10 10 10 6 Polycystin cation channel GPHH PF16905.3 001293281.1_23529001_1 - 5e-06 26.1 0.0 1.2e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated ATP-synt_B PF00430.16 001293281.1_23529001_1 - 0.0016 18.4 4.8 0.0016 18.4 4.8 2.8 2 0 0 2 2 2 1 ATP synthase B/B' CF(0) IQ PF00612.25 001293281.1_23529001_1 - 0.0018 17.8 0.4 0.0048 16.4 0.4 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif SieB PF14163.4 001293281.1_23529001_1 - 0.1 11.9 3.7 0.68 9.3 0.6 3.4 2 0 0 2 2 2 0 Super-infection exclusion protein B FLO_LFY PF01698.14 001293281.1_23529001_1 - 5 6.1 7.8 11 5.0 7.8 1.4 1 0 0 1 1 1 0 Floricaula / Leafy protein DUF4527 PF15030.4 001293281.1_23529001_1 - 6.2 6.1 7.1 11 5.3 7.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) DUF525 PF04379.12 001317356.1_23527001_2 - 1.4e-26 92.4 0.1 2.5e-26 91.6 0.1 1.4 1 0 0 1 1 1 1 ApaG domain YccV-like PF08755.9 001317356.1_23527001_2 - 1.5e-11 44.5 0.6 2.7e-11 43.7 0.1 1.7 2 0 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like Abhydrolase_1 PF00561.18 001033645.1_23524001_3 - 3.1e-39 135.0 0.0 4.1e-39 134.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001033645.1_23524001_3 - 1.6e-14 54.9 0.3 3.6e-14 53.8 0.3 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 001033645.1_23524001_3 - 5.1e-12 45.4 0.0 3.7e-11 42.6 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 HAD_2 PF13419.4 001033645.1_23524001_3 - 1.5e-08 34.8 0.0 3.1e-08 33.8 0.0 1.5 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.24 001033645.1_23524001_3 - 3.2e-05 24.2 0.0 5.5e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.4 001033645.1_23524001_3 - 0.00018 21.4 0.0 0.00036 20.4 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Ndr PF03096.12 001033645.1_23524001_3 - 0.023 13.2 0.0 0.057 12.0 0.0 1.5 2 0 0 2 2 2 0 Ndr family LRR_8 PF13855.4 001011691.3_23526001_1 - 4.2e-78 256.9 171.0 6.6e-13 48.1 1.3 12.1 3 3 12 15 15 15 14 Leucine rich repeat LRR_4 PF12799.5 001011691.3_23526001_1 - 8.7e-33 111.6 117.5 0.00011 22.3 8.2 13.4 6 4 7 15 15 15 14 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001011691.3_23526001_1 - 3.4e-26 91.5 27.4 1.9e-09 37.4 6.4 6.1 2 1 4 6 6 6 5 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001011691.3_23526001_1 - 3.8e-14 52.4 42.9 0.00057 19.3 1.0 7.1 1 1 5 7 7 7 6 Leucine-rich repeat TIR PF01582.18 001011691.3_23526001_1 - 3.9e-13 49.4 1.0 6.4e-13 48.7 1.0 1.3 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.4 001011691.3_23526001_1 - 2.7e-05 24.3 0.2 7.6e-05 22.8 0.1 1.7 2 0 0 2 2 2 1 TIR domain LRR_1 PF00560.31 001011691.3_23526001_1 - 0.00096 19.2 89.7 0.7 10.5 0.2 19.7 19 2 1 20 20 20 3 Leucine Rich Repeat LRRNT PF01462.16 001011691.3_23526001_1 - 0.0056 16.2 0.2 0.0056 16.2 0.2 2.1 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain DUF4525 PF15027.4 001011691.3_23526001_1 - 0.022 14.4 0.2 0.071 12.7 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) LRR_3 PF07725.10 001011691.3_23526001_1 - 2 8.3 10.4 1.5 8.7 0.0 4.8 5 0 0 5 5 5 0 Leucine Rich Repeat UNC-50 PF05216.11 001277753.1_23523001_1 - 4.2e-90 301.0 22.0 5.1e-90 300.7 22.0 1.1 1 0 0 1 1 1 1 UNC-50 family NPIP PF06409.9 001277558.2_23529001_1 - 7.1e-11 41.7 21.0 4e-07 29.4 10.5 2.9 2 1 0 2 2 2 2 Nuclear pore complex interacting protein (NPIP) SH3_2 PF07653.15 001277558.2_23529001_1 - 1.8e-07 30.6 0.0 4e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain KELK PF15796.3 001277558.2_23529001_1 - 0.0014 19.0 10.4 0.0014 19.0 10.4 7.9 3 2 4 7 7 7 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase DASH_Dam1 PF08653.8 001277558.2_23529001_1 - 2.3 8.0 6.6 29 4.4 0.3 4.2 3 0 0 3 3 3 0 DASH complex subunit Dam1 Neural_ProG_Cyt PF06567.9 001277558.2_23529001_1 - 2.7 8.1 14.0 0.88 9.7 0.9 4.1 3 0 0 3 3 3 0 Neural chondroitin sulphate proteoglycan cytoplasmic domain ATP_synt_H PF05493.11 001277387.1_23523001_1 - 8.6e-22 77.2 4.2 1.9e-21 76.2 4.2 1.6 1 0 0 1 1 1 1 ATP synthase subunit H Sushi PF00084.18 001033643.1_23524001_2 - 4.3e-73 241.7 37.4 1.8e-12 47.5 1.1 7.2 7 0 0 7 7 7 7 Sushi repeat (SCR repeat) cEGF PF12662.5 001033643.1_23524001_2 - 0.022 14.5 15.7 8.7 6.3 0.1 6.2 6 0 0 6 6 6 0 Complement Clr-like EGF-like PhoLip_ATPase_C PF16212.3 001277775.1_23528001_1 - 1.1e-83 280.7 23.7 1.1e-83 280.7 23.7 2.5 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.3 001277775.1_23528001_1 - 1.1e-26 92.2 4.8 3.5e-26 90.6 4.8 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.4 001277775.1_23528001_1 - 6e-14 51.8 0.1 7.5e-13 48.3 0.0 2.7 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 001277775.1_23528001_1 - 9.8e-10 38.9 1.5 0.00025 21.3 0.0 3.3 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.18 001277775.1_23528001_1 - 2.8e-09 36.5 0.9 8.5e-09 34.9 0.0 2.3 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.10 001277775.1_23528001_1 - 0.0024 17.5 5.2 0.0041 16.8 2.1 2.9 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase FimH_man-bind PF09160.8 001277775.1_23528001_1 - 0.0048 16.5 0.1 0.044 13.3 0.1 2.3 2 0 0 2 2 2 1 FimH, mannose binding ATP-synt_8 PF00895.18 001277775.1_23528001_1 - 6 7.3 7.2 6.1 7.3 0.7 3.5 3 0 0 3 3 3 0 ATP synthase protein 8 Oxysterol_BP PF01237.16 001008448.1_23527001_1 - 2.1e-148 493.9 0.2 2.6e-148 493.7 0.2 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein UvrB PF12344.6 001197057.1_23523001_2 - 0.11 12.3 0.3 0.19 11.5 0.3 1.3 1 0 0 1 1 1 0 Ultra-violet resistance protein B COX16 PF14138.4 001197057.1_23523001_3 - 1.9e-21 76.3 0.0 3e-21 75.6 0.0 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 COX17 PF05051.11 001302169.1_23522001_2 - 3.7e-21 75.1 6.5 6.5e-21 74.3 6.5 1.4 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) 7tm_1 PF00001.19 204406.1_23523001_1 - 5.7e-55 186.3 16.5 7.6e-55 185.9 16.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 204406.1_23523001_1 - 2.8e-10 39.9 15.9 4.6e-10 39.2 15.9 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 204406.1_23523001_1 - 8e-09 35.1 16.3 1e-08 34.8 16.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 204406.1_23523001_1 - 0.00025 20.3 14.5 0.00037 19.8 14.5 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx TAS2R PF05296.11 204406.1_23523001_1 - 0.0013 17.8 4.6 0.0013 17.8 4.6 2.0 2 0 0 2 2 2 1 Taste receptor protein (TAS2R) LETM1 PF07766.11 204406.1_23523001_1 - 0.043 13.0 0.1 0.075 12.2 0.1 1.3 1 0 0 1 1 1 0 LETM1-like protein DUF3810 PF12725.5 204406.1_23523001_1 - 0.17 11.1 3.8 0.36 10.0 3.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) p450 PF00067.20 001195557.1_23526001_3 - 6.8e-137 456.8 0.4 8.6e-137 456.5 0.4 1.1 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.23 001199409.1_23525001_2 - 1.1e-68 231.3 0.0 1.5e-68 230.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001199409.1_23525001_2 - 3.7e-45 154.1 0.0 5.3e-45 153.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 001199409.1_23525001_2 - 3.2e-15 56.1 0.1 8.4e-15 54.8 0.1 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 001199409.1_23525001_2 - 1.9e-08 33.8 0.0 4.3e-08 32.7 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.21 001199409.1_23525001_2 - 0.15 11.8 0.2 3.6 7.3 0.0 2.7 1 1 2 3 3 3 0 Phosphotransferase enzyme family PB1 PF00564.22 001031319.1_23529001_2 - 2.5e-14 52.8 0.0 4.2e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 PB1 domain Pkinase PF00069.23 001031319.1_23529001_3 - 5.5e-67 225.8 0.0 7e-67 225.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001031319.1_23529001_3 - 8e-34 117.0 0.0 1.1e-33 116.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 001031319.1_23529001_3 - 9.6e-12 44.5 7.9 2.3e-11 43.2 7.9 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.22 001031319.1_23529001_3 - 5.6e-05 23.6 2.2 0.00012 22.6 2.2 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 001031319.1_23529001_3 - 0.00019 20.7 0.0 0.00027 20.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001031319.1_23529001_3 - 0.033 13.4 0.0 0.054 12.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ion_trans PF00520.29 204899.2_23528001_2 - 1.1e-49 168.8 9.1 1.7e-49 168.1 9.1 1.3 1 0 0 1 1 1 1 Ion transport protein K_channel_TID PF07941.9 204899.2_23528001_2 - 4.1e-33 113.5 17.9 7.3e-33 112.7 17.9 1.4 1 0 0 1 1 1 1 Potassium channel Kv1.4 tandem inactivation domain BTB_2 PF02214.20 204899.2_23528001_2 - 4.3e-27 94.2 0.0 8.2e-27 93.3 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 204899.2_23528001_2 - 6.4e-13 48.4 4.9 6.4e-13 48.4 4.9 2.2 2 0 0 2 2 2 1 Ion channel Sigma_reg_N PF13800.4 204899.2_23528001_2 - 0.75 10.0 3.2 15 5.8 0.0 3.2 3 0 0 3 3 3 0 Sigma factor regulator N-terminal RasGEF PF00617.17 001031271.1_23528001_3 - 3.2e-58 196.6 1.5 5.5e-58 195.8 1.5 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.18 001031271.1_23528001_3 - 1.6e-19 69.9 0.1 8.1e-19 67.7 0.0 2.3 2 0 0 2 2 2 1 RasGEF N-terminal motif RA PF00788.21 001031271.1_23528001_3 - 1.9e-13 50.7 0.1 1.1e-12 48.3 0.0 2.3 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Acyl-CoA_ox_N PF14749.4 001031271.1_23528001_3 - 0.23 11.9 4.4 17 5.8 0.1 3.3 3 1 0 3 3 3 0 Acyl-coenzyme A oxidase N-terminal VGCC_alpha2 PF08473.9 001177322.3_23529001_1 - 1.1e-206 686.6 2.2 1.7e-206 686.0 2.2 1.3 1 0 0 1 1 1 1 Neuronal voltage-dependent calcium channel alpha 2acd VWA_N PF08399.9 001177322.3_23529001_1 - 1.2e-39 135.5 0.2 2e-39 134.7 0.2 1.4 1 0 0 1 1 1 1 VWA N-terminal VWA PF00092.26 001177322.3_23529001_1 - 2.1e-22 80.1 0.6 3.4e-22 79.4 0.6 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 001177322.3_23529001_1 - 3.1e-14 53.0 0.0 4.5e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_1 PF02743.16 001177322.3_23529001_1 - 9.4e-11 41.8 3.8 6.7e-10 39.1 0.1 3.3 3 0 0 3 3 3 1 Cache domain vWA-TerF-like PF10138.7 001177322.3_23529001_1 - 0.0079 16.2 0.4 0.013 15.4 0.4 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus DUF3983 PF13137.4 001177322.3_23529001_1 - 0.015 15.0 0.2 0.032 13.9 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3983) Pkinase PF00069.23 001031326.1_23525001_2 - 5.6e-50 170.0 0.1 7.1e-50 169.7 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001031326.1_23525001_2 - 1.3e-20 73.6 0.0 3.2e-20 72.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase 7tm_1 PF00001.19 001024584.1_23524001_2 - 9.2e-58 195.5 22.8 1.2e-57 195.1 22.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Orexin_rec2 PF03827.11 001024584.1_23524001_2 - 2.5e-27 94.5 5.0 2.5e-27 94.5 5.0 1.7 2 0 0 2 2 2 1 Orexin receptor type 2 7tm_4 PF13853.4 001024584.1_23524001_2 - 0.00026 20.7 11.1 0.00026 20.7 11.1 1.8 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001024584.1_23524001_2 - 0.0014 17.9 22.6 0.0048 16.2 22.6 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx zf-CCCH PF00642.22 001024584.1_23524001_3 - 0.044 13.6 0.3 0.21 11.4 0.0 2.2 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PhzC-PhzF PF02567.14 001277337.1_23523001_3 - 1.7e-60 204.8 0.0 2e-60 204.5 0.0 1.1 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein LUC7 PF03194.13 001030755.1_23525001_1 - 1.1e-79 267.4 14.6 1.1e-79 267.4 14.6 2.1 1 1 1 2 2 2 1 LUC7 N_terminus Acyl-CoA_dh_1 PF00441.22 001006136.2_23525001_3 - 1.3e-42 145.4 0.1 3.3e-38 131.1 0.1 2.3 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.17 001006136.2_23525001_3 - 1.1e-25 89.5 0.0 1.9e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.14 001006136.2_23525001_3 - 5.7e-24 84.8 0.0 1.6e-23 83.3 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.9 001006136.2_23525001_3 - 1.3e-08 35.0 0.0 1.9e-07 31.3 0.0 2.8 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Neur_chan_LBD PF02931.21 001277696.1_23524001_1 - 1.1e-49 168.6 0.0 2.8e-49 167.3 0.0 1.6 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 001277696.1_23524001_1 - 1.5e-48 165.8 0.1 2e-48 165.4 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region EF-hand_1 PF00036.30 204376.2_23526001_3 - 3.5e-24 82.4 13.9 1.1e-05 24.4 0.4 4.7 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.4 204376.2_23526001_3 - 1.8e-23 82.6 2.2 7.3e-13 48.7 0.3 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 204376.2_23526001_3 - 1.2e-18 65.5 8.3 0.00015 21.0 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.4 204376.2_23526001_3 - 1.7e-18 64.8 7.5 0.00011 21.7 0.2 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.4 204376.2_23526001_3 - 2.6e-15 55.8 8.0 0.0069 16.0 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.7 204376.2_23526001_3 - 1.4e-06 28.5 0.1 0.026 14.7 0.0 2.4 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 204376.2_23526001_3 - 4.8e-05 23.1 3.0 0.043 13.6 0.1 3.1 2 2 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.4 204376.2_23526001_3 - 0.05 13.8 0.1 0.57 10.4 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain Ins145_P3_rec PF08709.9 001174059.1_23529001_1 - 2.4e-95 317.6 0.0 2.1e-94 314.5 0.0 2.4 3 0 0 3 3 3 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RYDR_ITPR PF01365.19 001174059.1_23529001_1 - 2.1e-71 239.5 24.5 1.9e-61 207.0 0.5 4.9 5 0 0 5 5 5 2 RIH domain MIR PF02815.17 001174059.1_23529001_1 - 5.7e-71 238.1 0.2 8.5e-68 227.7 0.0 2.6 2 0 0 2 2 2 2 MIR domain RIH_assoc PF08454.9 001174059.1_23529001_1 - 2.6e-31 107.3 6.9 2.6e-31 107.3 6.9 6.2 7 1 0 7 7 7 2 RyR and IP3R Homology associated Ion_trans PF00520.29 001174059.1_23529001_1 - 2.6e-19 69.3 8.6 6e-19 68.1 8.6 1.6 1 0 0 1 1 1 1 Ion transport protein CENP-Q PF13094.4 001174059.1_23529001_1 - 0.091 12.8 2.4 0.26 11.3 0.7 2.8 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit MscS_porin PF12795.5 001174059.1_23529001_1 - 0.24 10.8 5.5 0.058 12.8 1.4 2.0 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Clat_adaptor_s PF01217.18 001030008.1_23522001_2 - 2e-57 193.0 3.4 2e-57 193.0 3.4 1.6 2 0 0 2 2 2 1 Clathrin adaptor complex small chain Ig_3 PF13927.4 205084.2_23523001_3 - 1.3e-12 48.0 1.9 2.1e-05 24.9 0.4 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 205084.2_23523001_3 - 4.3e-10 39.6 2.6 4.7e-08 33.0 0.2 2.3 2 0 0 2 2 2 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 205084.2_23523001_3 - 6e-10 38.9 0.1 2.1e-09 37.2 0.1 1.9 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain I-set PF07679.14 205084.2_23523001_3 - 3.9e-09 36.3 0.2 0.00051 19.9 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 205084.2_23523001_3 - 3.8e-08 33.2 1.2 0.011 15.8 0.0 3.7 2 2 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.13 205084.2_23523001_3 - 1.1e-05 25.6 1.3 0.00038 20.7 0.0 3.0 2 1 1 3 3 3 1 Immunoglobulin C1-set domain Ig_2 PF13895.4 205084.2_23523001_3 - 0.0018 18.5 9.7 0.0051 17.0 0.4 3.4 3 1 0 3 3 3 2 Immunoglobulin domain Phage_holin_2_3 PF16080.3 205084.2_23523001_3 - 0.062 12.9 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Bacteriophage holin family HP1 MLANA PF14991.4 205084.2_23523001_3 - 0.085 13.0 0.0 0.24 11.6 0.0 1.8 1 0 0 1 1 1 0 Protein melan-A DnaJ PF00226.29 001277777.1_23522001_1 - 1e-06 28.7 0.0 1.8e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.11 001277777.1_23522001_1 - 0.0027 17.6 0.0 0.0033 17.3 0.0 1.3 1 0 0 1 1 1 1 Pam16 C2 PF00168.28 001080889.1_23525001_2 - 5.7e-33 113.2 0.0 7.7e-19 67.8 0.0 2.2 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.14 001080889.1_23525001_2 - 0.0045 17.1 0.0 0.0097 16.0 0.0 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger DUF3029 PF11230.6 001080889.1_23525001_2 - 0.22 9.7 0.0 0.31 9.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3029) zf-C4 PF00105.16 204728.1_23524001_2 - 3.1e-28 97.9 17.0 5.9e-28 97.0 17.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 204728.1_23524001_2 - 4.7e-16 58.9 0.0 1e-15 57.8 0.0 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Hormone_recep PF00104.28 001007081.1_23523001_1 - 3.8e-33 114.7 0.4 5.7e-33 114.1 0.4 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001007081.1_23523001_1 - 6.1e-31 106.6 12.3 1.3e-30 105.5 12.3 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) GAT PF03127.12 001007081.1_23523001_1 - 0.23 11.7 2.1 0.67 10.2 0.3 2.5 2 0 0 2 2 2 0 GAT domain GCM PF03615.13 001008480.2_23524001_1 - 6.9e-72 239.7 1.1 1.1e-71 239.1 1.1 1.3 1 0 0 1 1 1 1 GCM motif protein PAC1 PF16094.3 001012543.1_23525001_2 - 2.2e-133 443.7 0.5 2.8e-133 443.3 0.5 1.1 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 AdoHcyase PF05221.15 001030913.1_23527001_1 - 2.5e-98 328.7 0.0 6.3e-64 215.8 0.7 2.1 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.19 001030913.1_23527001_1 - 1.5e-80 268.8 2.1 2.2e-80 268.3 2.1 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.17 001030913.1_23527001_1 - 5.5e-09 35.5 0.1 9.9e-09 34.6 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.10 001030913.1_23527001_1 - 5.7e-05 22.6 0.0 0.0001 21.8 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain THF_DHG_CYH_C PF02882.17 001030913.1_23527001_1 - 0.004 16.3 0.8 0.01 15.0 0.8 1.6 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.18 001030913.1_23527001_1 - 0.009 15.9 0.1 0.02 14.8 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.4 001030913.1_23527001_1 - 0.016 15.5 0.8 0.04 14.2 0.8 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding AlaDh_PNT_C PF01262.19 001030913.1_23527001_1 - 0.025 13.7 0.8 0.061 12.5 0.8 1.5 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.16 001030913.1_23527001_1 - 0.038 14.1 0.1 0.088 12.9 0.1 1.6 1 1 0 1 1 1 0 TrkA-N domain Big_3_5 PF16640.3 001030913.1_23527001_1 - 0.08 13.0 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) SR-25 PF10500.7 001030913.1_23527001_1 - 0.7 9.3 9.9 1.1 8.7 9.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AdoHcyase PF05221.15 001030913.1_23527001_3 - 4.7e-13 48.8 0.0 6.3e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase zf-rbx1 PF12678.5 001199250.1_23522001_1 - 3.4e-25 88.0 12.9 6.9e-25 87.0 12.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.5 001199250.1_23522001_1 - 4.8e-17 61.7 9.9 7.5e-17 61.0 9.9 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.4 001199250.1_23522001_1 - 0.00013 21.6 3.3 0.00013 21.6 3.3 2.9 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001199250.1_23522001_1 - 0.00014 22.0 14.7 0.00014 22.0 14.7 3.2 3 1 0 3 3 3 1 Ring finger domain zf-RING_11 PF17123.3 001199250.1_23522001_1 - 0.0029 17.2 2.1 0.0029 17.2 2.1 3.6 4 0 0 4 4 4 1 RING-like zinc finger zf-C3HC4 PF00097.23 001199250.1_23522001_1 - 10 6.0 24.3 0.037 13.8 11.5 3.2 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) ATP-synt_C PF00137.19 001277856.1_23522001_1 - 3.6e-11 43.1 12.4 6.8e-11 42.2 12.4 1.5 1 0 0 1 1 1 1 ATP synthase subunit C TMC PF07810.11 001006580.1_23526001_1 - 8.1e-38 129.3 3.4 2.3e-37 127.8 3.4 1.9 1 0 0 1 1 1 1 TMC domain Exo_endo_phos PF03372.21 001031047.1_23525001_2 - 1.6e-13 50.7 0.0 2.3e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Imm8 PF15586.4 001031047.1_23525001_2 - 0.12 12.2 0.2 0.3 11.0 0.2 1.7 1 1 1 2 2 2 0 Immunity protein 8 Motile_Sperm PF00635.24 001080869.1_23525001_3 - 4.9e-33 113.1 0.2 8e-33 112.4 0.2 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ASH PF15780.3 001080869.1_23525001_3 - 0.033 14.3 0.0 0.063 13.4 0.0 1.4 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Mito_carr PF00153.25 001012883.1_23525001_2 - 9.8e-60 198.4 0.6 8.2e-20 70.4 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Ras PF00071.20 001031327.2_23527001_1 - 1e-50 171.4 0.0 1.4e-50 170.9 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001031327.2_23527001_1 - 2e-17 63.4 0.0 3.5e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001031327.2_23527001_1 - 1.5e-07 30.9 0.0 2.3e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001031327.2_23527001_1 - 0.019 14.4 0.0 0.03 13.7 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain PBP1_TM PF14812.4 001031327.2_23527001_3 - 1.2 9.5 4.5 2.6 8.4 4.5 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Zona_pellucida PF00100.21 001039098.1_23526001_3 - 6.7e-41 140.6 0.0 1.4e-40 139.5 0.0 1.6 1 0 0 1 1 1 1 Zona pellucida-like domain MFS_1 PF07690.14 001031562.1_23526001_1 - 1.3e-16 60.4 18.3 9.6e-16 57.5 18.1 2.1 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.14 001031562.1_23526001_3 - 2.6e-06 26.5 5.2 6.4e-06 25.2 5.2 1.6 1 0 0 1 1 1 1 Major Facilitator Superfamily IL6Ra-bind PF09240.8 001256152.1_23525001_1 - 4.1e-23 81.5 0.3 1.2e-22 80.0 0.1 1.9 2 0 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding fn3 PF00041.19 001256152.1_23525001_1 - 0.0085 16.3 0.8 1.8 8.8 0.1 2.9 3 0 0 3 3 3 2 Fibronectin type III domain Tissue_fac PF01108.15 001256152.1_23525001_1 - 0.021 14.5 9.4 1.4 8.7 0.4 3.5 3 1 0 3 3 3 0 Tissue factor EpoR_lig-bind PF09067.8 001256152.1_23525001_1 - 0.98 9.5 5.8 0.26 11.4 1.9 2.0 2 0 0 2 2 2 0 Erythropoietin receptor, ligand binding Integrin_beta PF00362.16 204315.1_23527001_2 - 3.8e-111 370.5 0.0 5.3e-111 370.1 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 204315.1_23527001_2 - 2e-22 78.4 0.5 2e-22 78.4 0.5 2.2 3 0 0 3 3 3 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 204315.1_23527001_2 - 5.7e-22 77.9 9.4 5.7e-22 77.9 9.4 4.4 3 1 1 4 4 4 1 Integrin beta tail domain EGF_2 PF07974.11 204315.1_23527001_2 - 4.8e-08 33.1 40.1 4.6e-06 26.8 15.5 7.9 8 1 1 9 9 9 4 EGF-like domain RNA_pol_A_CTD PF03118.13 204315.1_23527001_2 - 0.051 13.2 0.4 0.13 11.9 0.1 1.7 2 0 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain Arf PF00025.19 001277714.1_23524001_3 - 6.2e-38 129.9 0.0 9.4e-38 129.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 001277714.1_23524001_3 - 2e-08 34.4 0.0 3e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.10 001277714.1_23524001_3 - 4.2e-06 26.2 0.0 5.8e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.20 001277714.1_23524001_3 - 5.9e-06 25.8 0.0 8.5e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 001277714.1_23524001_3 - 0.00014 21.2 0.0 0.00022 20.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 001277714.1_23524001_3 - 0.00048 20.1 0.0 0.00074 19.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.18 001277714.1_23524001_3 - 0.0012 18.0 0.0 0.0063 15.6 0.0 1.8 1 1 1 2 2 2 1 G-protein alpha subunit AAA_16 PF13191.4 001277714.1_23524001_3 - 0.016 15.4 1.9 0.92 9.7 0.0 2.3 1 1 1 2 2 2 0 AAA ATPase domain GTP_EFTU PF00009.25 001277714.1_23524001_3 - 0.046 13.1 0.0 0.072 12.5 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain DnaGprimase_HBD PF16730.3 001277714.1_23524001_3 - 0.12 12.3 0.4 0.18 11.7 0.4 1.2 1 0 0 1 1 1 0 DnaG-primase C-terminal, helicase-binding domain Ras PF00071.20 001278152.1_23523001_1 - 4e-50 169.5 0.0 5.2e-50 169.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001278152.1_23523001_1 - 7.5e-21 74.5 0.0 1.4e-20 73.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001278152.1_23523001_1 - 2.8e-07 30.1 0.0 4.1e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.18 001278152.1_23523001_1 - 0.032 13.2 0.0 0.045 12.8 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit ABC_tran PF00005.25 001278152.1_23523001_1 - 0.1 13.0 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 ABC transporter DUF258 PF03193.14 001278152.1_23523001_1 - 0.11 12.2 0.2 17 5.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function, DUF258 RNA_pol_Rpb6 PF01192.20 204734.1_23522001_1 - 1e-15 57.2 0.2 1.6e-15 56.6 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 BDHCT_assoc PF16204.3 204734.1_23522001_1 - 2.2 7.8 5.2 3.1 7.3 5.2 1.2 1 0 0 1 1 1 0 BDHCT-box associated domain on Bloom syndrome protein G-alpha PF00503.18 204234.1_23523001_2 - 7.2e-116 387.1 3.5 8.7e-116 386.8 3.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 204234.1_23523001_2 - 3.5e-14 52.5 2.6 4e-11 42.5 0.2 2.8 2 2 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 204234.1_23523001_2 - 0.007 15.6 6.1 0.061 12.5 0.1 3.0 2 1 0 3 3 3 2 Gtr1/RagA G protein conserved region Roc PF08477.11 204234.1_23523001_2 - 0.045 13.9 1.1 4.4 7.4 0.2 2.6 1 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.21 204234.1_23523001_2 - 0.08 12.9 0.0 1.3 9.0 0.0 2.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF3142 PF11340.6 204234.1_23523001_2 - 0.15 11.7 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) IL8 PF00048.18 001293309.1_23522001_1 - 2.8e-16 59.3 0.5 4.3e-16 58.7 0.5 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Rcd1 PF04078.11 001006521.2_23525001_3 - 1.5e-135 450.3 0.9 1.9e-135 450.1 0.9 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Lipocalin PF00061.21 001030889.1_23521001_1 - 2.3e-31 108.8 1.8 2.6e-31 108.6 1.8 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001030889.1_23521001_1 - 1.9e-09 37.4 0.7 2.2e-09 37.2 0.7 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Myosin_N PF02736.17 001030889.1_23521001_1 - 0.054 13.2 3.6 0.47 10.2 0.3 2.9 2 1 1 3 3 3 0 Myosin N-terminal SH3-like domain DUF424 PF04242.11 001030889.1_23521001_1 - 0.09 12.9 0.0 3.1 8.0 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF424) FKBP_C PF00254.26 204847.2_23527001_2 - 1.9e-109 358.1 0.0 2.2e-26 91.9 0.0 5.1 5 0 0 5 5 5 4 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_1 PF00036.30 204847.2_23527001_2 - 7.4e-09 34.4 0.9 0.0011 18.2 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 204847.2_23527001_2 - 1.5e-05 25.2 0.7 4.6e-05 23.7 0.7 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 204847.2_23527001_2 - 8.8e-05 22.0 0.5 0.19 11.7 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 204847.2_23527001_2 - 0.00012 21.3 0.4 0.22 11.0 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 204847.2_23527001_2 - 0.00058 19.5 0.1 1.2 8.8 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair DUF2895 PF11444.6 204847.2_23527001_2 - 0.061 12.6 0.0 7.5 5.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2895) LRR_8 PF13855.4 001044667.1_23526001_1 - 1.6e-25 88.5 6.8 2.1e-13 49.7 0.1 2.6 2 0 0 2 2 2 2 Leucine rich repeat I-set PF07679.14 001044667.1_23526001_1 - 2e-12 46.9 0.0 5.9e-12 45.4 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_4 PF12799.5 001044667.1_23526001_1 - 8.2e-12 45.0 6.7 0.00015 21.9 0.6 3.8 3 1 0 3 3 3 3 Leucine Rich repeats (2 copies) Ig_3 PF13927.4 001044667.1_23526001_1 - 1.6e-11 44.5 0.0 4.1e-11 43.2 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001044667.1_23526001_1 - 2.5e-07 30.6 0.0 6e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain LRR_5 PF13306.4 001044667.1_23526001_1 - 6.7e-07 29.2 0.2 1.3e-05 25.1 0.0 2.5 2 1 0 2 2 2 1 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001044667.1_23526001_1 - 3.9e-06 26.3 1.1 0.047 13.1 0.1 2.2 1 1 1 2 2 2 2 Leucine-rich repeat V-set PF07686.15 001044667.1_23526001_1 - 4.4e-06 26.7 0.0 1.6e-05 24.9 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.4 001044667.1_23526001_1 - 1e-05 25.6 0.3 4.3e-05 23.7 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin domain LRR_1 PF00560.31 001044667.1_23526001_1 - 0.013 15.7 2.4 10 6.9 0.1 5.0 5 1 0 5 5 3 0 Leucine Rich Repeat fn3 PF00041.19 001044667.1_23526001_1 - 0.014 15.5 0.0 0.049 13.8 0.0 1.9 1 0 0 1 1 1 0 Fibronectin type III domain TPKR_C2 PF16920.3 001044667.1_23526001_1 - 0.02 14.9 1.9 0.052 13.5 1.9 1.7 1 0 0 1 1 1 0 Tyrosine-protein kinase receptor C2 Ig-like domain DUF1510 PF07423.9 001044667.1_23526001_1 - 0.02 14.2 0.7 0.036 13.4 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) MAP17 PF15807.3 001044667.1_23526001_1 - 0.067 13.3 1.5 0.2 11.8 0.5 2.1 1 1 1 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 LRR_6 PF13516.4 001044667.1_23526001_1 - 0.1 12.5 3.8 9.8 6.4 0.1 4.0 4 0 0 4 4 4 0 Leucine Rich repeat Nucleo_P87 PF07267.9 001044667.1_23526001_1 - 6.3 5.4 7.3 9.3 4.8 7.3 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Nop14 PF04147.10 001044667.1_23526001_1 - 9.3 4.2 12.9 14 3.6 12.9 1.1 1 0 0 1 1 1 0 Nop14-like family SNF PF00209.16 001031279.1_23528001_1 - 1.3e-229 763.1 43.4 1.5e-229 762.9 43.4 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Pkinase PF00069.23 204295.1_23524001_3 - 9.7e-75 251.2 0.0 2.3e-74 250.0 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain CaMKII_AD PF08332.8 204295.1_23524001_3 - 6.8e-64 213.6 0.0 1.1e-63 212.9 0.0 1.4 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain Pkinase_Tyr PF07714.15 204295.1_23524001_3 - 2.2e-32 112.2 0.0 3.6e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SnoaL_3 PF13474.4 204295.1_23524001_3 - 9.9e-09 35.4 0.0 1.9e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.4 204295.1_23524001_3 - 1.1e-07 32.0 0.0 2.2e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) APH PF01636.21 204295.1_23524001_3 - 0.0066 16.3 0.7 2.1 8.0 0.3 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.12 204295.1_23524001_3 - 0.017 14.4 0.2 0.033 13.4 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SnoaL_2 PF12680.5 204295.1_23524001_3 - 0.13 12.8 0.0 0.29 11.7 0.0 1.5 1 0 0 1 1 1 0 SnoaL-like domain Sugar_tr PF00083.22 001146131.1_23524001_1 - 4.2e-28 98.3 17.7 6e-28 97.8 17.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001146131.1_23524001_1 - 4.9e-26 91.4 49.5 4.9e-23 81.5 31.1 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily Gelsolin PF00626.20 001030635.1_23528001_3 - 1.4e-62 207.4 2.5 3.1e-15 55.7 0.0 6.8 6 0 0 6 6 6 6 Gelsolin repeat LRR_8 PF13855.4 001030635.1_23528001_3 - 1.4e-38 130.3 43.7 1.1e-09 37.8 7.8 7.1 5 2 2 7 7 7 7 Leucine rich repeat LRR_4 PF12799.5 001030635.1_23528001_3 - 7.5e-22 76.8 56.7 9.3e-06 25.7 4.7 9.4 4 2 5 10 10 10 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001030635.1_23528001_3 - 3.5e-05 23.3 20.7 0.0065 15.9 2.6 4.0 1 1 3 4 4 4 3 Leucine-rich repeat SRP-alpha_N PF04086.11 001030635.1_23528001_3 - 0.0095 15.7 1.4 0.0095 15.7 1.4 2.1 2 0 0 2 2 2 1 Signal recognition particle, alpha subunit, N-terminal LEDGF PF11467.6 001030635.1_23528001_3 - 0.089 12.3 0.6 1.1 8.7 0.0 2.7 1 1 1 2 2 2 0 Lens epithelium-derived growth factor (LEDGF) LRR_5 PF13306.4 001030635.1_23528001_3 - 0.15 11.9 2.3 7.8 6.3 0.3 3.0 2 1 1 3 3 3 0 Leucine rich repeats (6 copies) LRR_1 PF00560.31 001030635.1_23528001_3 - 0.18 12.3 48.5 4.3 8.1 0.3 12.1 13 1 0 13 13 13 0 Leucine Rich Repeat Arm PF00514.21 001012841.2_23527001_3 - 2.9e-87 284.2 22.0 1.6e-13 50.0 0.0 9.0 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat IBB PF01749.18 001012841.2_23527001_3 - 1.5e-24 86.0 1.5 3.1e-24 85.0 1.5 1.6 1 0 0 1 1 1 1 Importin beta binding domain Arm_3 PF16186.3 001012841.2_23527001_3 - 3.7e-23 80.7 2.0 9.1e-23 79.4 2.0 1.7 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_EZ PF13513.4 001012841.2_23527001_3 - 3.3e-21 75.2 3.3 3.2e-07 30.5 0.0 5.8 5 1 0 5 5 5 3 HEAT-like repeat HEAT_2 PF13646.4 001012841.2_23527001_3 - 1.2e-19 70.3 0.0 5.7e-07 29.7 0.0 4.7 2 2 2 4 4 4 4 HEAT repeats HEAT PF02985.20 001012841.2_23527001_3 - 5.5e-13 47.8 6.4 0.0047 16.9 0.0 7.2 8 0 0 8 8 7 2 HEAT repeat RICTOR_V PF14668.4 001012841.2_23527001_3 - 1.4e-05 25.1 0.6 0.93 9.6 0.0 4.5 3 1 1 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_C PF11698.6 001012841.2_23527001_3 - 4e-05 23.6 0.0 0.35 10.9 0.0 4.0 3 1 1 4 4 4 2 V-ATPase subunit H Arm_2 PF04826.11 001012841.2_23527001_3 - 0.00013 21.4 0.0 0.21 10.9 0.0 2.6 1 1 1 2 2 2 2 Armadillo-like HEAT_PBS PF03130.14 001012841.2_23527001_3 - 0.0079 16.7 0.2 17 6.3 0.0 4.4 4 0 0 4 4 3 0 PBS lyase HEAT-like repeat CTNNBL PF08216.9 001012841.2_23527001_3 - 0.15 12.1 0.0 6.5 6.8 0.0 3.3 4 0 0 4 4 4 0 Catenin-beta-like, Arm-motif containing nuclear NUSAP PF16006.3 001012841.2_23527001_3 - 1.1 8.9 3.8 1.5 8.3 3.8 1.1 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein PHO4 PF01384.18 001305398.1_23526001_2 - 4.9e-136 453.0 8.1 6.2e-136 452.7 8.1 1.1 1 0 0 1 1 1 1 Phosphate transporter family Vpu PF00558.17 001305398.1_23526001_2 - 0.044 13.4 0.2 0.044 13.4 0.2 2.1 2 0 0 2 2 2 0 Vpu protein Lep_receptor_Ig PF06328.9 204871.1_23526001_3 - 3.5e-29 100.5 0.3 9.3e-29 99.2 0.3 1.8 1 0 0 1 1 1 1 Ig-like C2-type domain fn3 PF00041.19 204871.1_23526001_3 - 9.7e-29 99.4 10.1 1.9e-09 37.6 0.4 5.3 6 0 0 6 6 6 4 Fibronectin type III domain fn3_2 PF16893.3 204871.1_23526001_3 - 8.9e-05 22.4 0.3 0.0023 17.9 0.1 2.7 3 0 0 3 3 3 1 Fibronectin type III domain EpoR_lig-bind PF09067.8 204871.1_23526001_3 - 0.00051 20.1 0.1 0.0013 18.8 0.1 1.7 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding IL6Ra-bind PF09240.8 204871.1_23526001_3 - 0.011 16.0 0.9 0.028 14.7 0.1 2.2 2 0 0 2 2 2 0 Interleukin-6 receptor alpha chain, binding Pur_ac_phosph_N PF16656.3 204871.1_23526001_3 - 0.026 15.0 10.2 0.84 10.1 0.0 4.2 4 1 0 4 4 4 0 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 204871.1_23526001_3 - 0.073 13.3 0.0 15 5.8 0.0 3.0 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III Pkinase PF00069.23 001162372.3_23527001_3 - 8.7e-73 244.8 0.0 1.3e-72 244.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001162372.3_23527001_3 - 1.3e-46 158.9 0.0 2.2e-46 158.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 001162372.3_23527001_3 - 4.9e-24 84.4 0.0 1.3e-23 83.0 0.0 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 001162372.3_23527001_3 - 1.5e-07 30.9 0.1 0.00059 19.1 0.0 2.3 1 1 1 2 2 2 2 Kinase-like Kdo PF06293.12 001162372.3_23527001_3 - 0.017 14.3 0.0 0.21 10.8 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001162372.3_23527001_3 - 0.022 14.6 0.0 0.22 11.2 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family DSHCT PF08148.10 001162372.3_23527001_3 - 0.041 13.4 0.0 0.078 12.5 0.0 1.4 1 0 0 1 1 1 0 DSHCT (NUC185) domain Nuc_sug_transp PF04142.13 204513.1_23523001_3 - 1.8e-120 401.8 26.3 2.1e-120 401.5 26.3 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.9 204513.1_23523001_3 - 1.2e-05 24.6 15.8 1.2e-05 24.6 15.8 1.8 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.18 204513.1_23523001_3 - 0.057 13.5 34.3 0.87 9.6 9.0 3.0 2 1 1 3 3 3 0 EamA-like transporter family ChaC PF04752.10 001199656.1_23524001_3 - 3.7e-62 209.4 0.0 7.7e-62 208.4 0.0 1.5 2 0 0 2 2 2 1 ChaC-like protein GGACT PF06094.10 001199656.1_23524001_3 - 0.004 17.6 0.0 0.0064 17.0 0.0 1.3 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like PTEN_C2 PF10409.7 001177415.1_23529001_1 - 9.2e-28 96.6 0.0 1.9e-27 95.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DnaJ PF00226.29 001177415.1_23529001_1 - 3.7e-06 26.8 0.0 7.8e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain Y_phosphatase PF00102.25 001177415.1_23529001_1 - 0.021 14.3 0.1 0.038 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase FA_desaturase PF00487.22 204890.1_23523001_1 - 2.3e-13 50.4 11.0 2.3e-13 50.4 11.0 1.8 2 0 0 2 2 2 1 Fatty acid desaturase TIR_2 PF13676.4 001024829.1_23523001_3 - 6.9e-15 55.1 0.0 1.1e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 TIR domain TIR PF01582.18 001024829.1_23523001_3 - 2.9e-09 36.8 0.0 4.2e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 TIR domain CCDC106 PF15794.3 001024829.1_23523001_3 - 2.2 7.8 4.8 3.2 7.3 4.8 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 7tm_1 PF00001.19 001318420.1_23524001_3 - 5.6e-68 228.9 13.4 8.1e-68 228.4 13.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001318420.1_23524001_3 - 4.9e-15 55.5 17.9 7.7e-15 54.8 17.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001318420.1_23524001_3 - 1.3e-06 28.2 8.8 1.3e-06 28.2 8.8 1.7 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001318420.1_23524001_3 - 5.3e-05 22.5 16.1 5.3e-05 22.5 16.1 2.9 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx Pkinase_Tyr PF07714.15 001044669.1_23529001_1 - 1.3e-77 260.5 0.0 1.7e-77 260.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 001044669.1_23529001_1 - 7.2e-62 206.3 1.5 1e-29 102.7 0.5 2.3 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.4 001044669.1_23529001_1 - 1.2e-53 180.3 76.4 4.7e-47 158.9 27.3 3.9 2 1 1 3 3 3 3 Growth factor receptor domain IV Furin-like PF00757.18 001044669.1_23529001_1 - 1.8e-36 125.1 84.6 1.2e-31 109.5 36.7 4.3 2 1 1 3 3 3 2 Furin-like cysteine rich region Pkinase PF00069.23 001044669.1_23529001_1 - 1e-31 110.1 0.0 1.7e-31 109.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.4 001044669.1_23529001_1 - 0.088 12.0 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Rap_GAP PF02145.13 001277451.1_23529001_1 - 5.8e-48 162.8 0.0 1.2e-47 161.7 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP DUF837 PF05769.9 001277451.1_23529001_1 - 0.17 11.7 2.2 0.49 10.2 2.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF837) HSBP1 PF06825.10 001136182.2_23522001_3 - 5e-18 64.6 0.6 7.5e-18 64.1 0.6 1.2 1 0 0 1 1 1 1 Heat shock factor binding protein 1 Apolipoprotein PF01442.16 001136182.2_23522001_3 - 0.054 13.3 0.2 0.075 12.8 0.2 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain PHR PF08005.10 001005819.1_23525001_2 - 5.4e-50 169.8 0.7 8e-50 169.3 0.7 1.3 1 0 0 1 1 1 1 PHR domain BTB PF00651.29 001005819.1_23525001_2 - 7.5e-25 87.2 0.1 1.2e-23 83.3 0.0 2.3 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.13 001005819.1_23525001_2 - 6.3e-09 35.7 0.2 4.5e-08 33.0 0.0 2.4 2 1 0 2 2 2 1 BTB And C-terminal Kelch ATP-synt_C PF00137.19 001278024.1_23523001_1 - 4.1e-36 123.0 37.1 6.4e-22 77.5 14.1 2.4 2 0 0 2 2 2 2 ATP synthase subunit C Pkinase PF00069.23 001135786.1_23522001_1 - 3e-76 256.1 0.0 3.4e-76 256.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001135786.1_23522001_1 - 9.7e-35 120.0 0.0 1.2e-34 119.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001135786.1_23522001_1 - 0.0011 18.2 0.0 0.031 13.5 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.9 001135786.1_23522001_1 - 0.0096 14.9 0.0 0.015 14.3 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.21 001135786.1_23522001_1 - 0.024 14.5 0.1 0.043 13.6 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family V-ATPase_G PF03179.13 001277677.1_23523001_3 - 8.7e-38 128.9 16.8 1.1e-37 128.6 16.8 1.1 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit OmpH PF03938.12 001277677.1_23523001_3 - 0.39 10.6 14.0 0.61 9.9 14.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Death PF00531.20 001012405.2_23527001_1 - 1.8e-08 34.3 0.0 3e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Death domain Chromo_shadow PF01393.17 204643.1_23527001_1 - 1.6e-31 108.0 0.1 4.3e-28 97.0 0.0 2.4 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.22 204643.1_23527001_1 - 1.2e-17 63.4 0.1 3.3e-15 55.6 0.1 2.5 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.4 204643.1_23527001_1 - 0.16 12.0 0.1 0.42 10.7 0.1 1.7 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 HLH PF00010.24 204282.1_23523001_2 - 2.4e-12 46.5 0.0 3.8e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain OATP PF03137.18 001039097.1_23525001_1 - 3.7e-180 599.7 14.7 5.1e-180 599.2 14.7 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 001039097.1_23525001_1 - 1.3e-23 83.3 17.4 1.4e-19 70.1 1.8 3.2 3 0 0 3 3 3 3 Major Facilitator Superfamily Kazal_2 PF07648.13 001039097.1_23525001_1 - 1.3e-10 41.1 4.4 1.3e-10 41.1 4.4 2.0 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 001039097.1_23525001_1 - 0.00018 21.3 2.9 0.0005 19.9 2.9 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Ion_trans PF00520.29 204279.1_23525001_3 - 9.7e-43 146.0 12.3 1.3e-42 145.6 12.3 1.2 1 0 0 1 1 1 1 Ion transport protein DUF3399 PF11879.6 204279.1_23525001_3 - 1.2e-41 141.2 9.3 2.6e-41 140.0 9.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3399) BTB_2 PF02214.20 204279.1_23525001_3 - 1.4e-27 95.7 0.2 6.6e-27 93.6 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain Ion_trans_2 PF07885.14 204279.1_23525001_3 - 1.8e-13 50.1 5.9 1.8e-13 50.1 5.9 2.5 2 0 0 2 2 2 1 Ion channel Shal-type PF11601.6 204279.1_23525001_3 - 1.5e-11 43.5 15.0 3.3e-11 42.4 15.0 1.6 1 0 0 1 1 1 1 Shal-type voltage-gated potassium channels, N-terminal PKD_channel PF08016.10 204279.1_23525001_3 - 0.00042 19.0 5.5 0.00077 18.1 5.5 1.3 1 0 0 1 1 1 1 Polycystin cation channel BTB_3 PF16017.3 204279.1_23525001_3 - 0.0016 18.4 0.0 0.01 15.8 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain RAMP PF04901.11 001144973.1_23521001_2 - 8.2e-43 144.8 3.6 1.1e-42 144.4 3.6 1.1 1 0 0 1 1 1 1 Receptor activity modifying family DUF761 PF05553.9 001144973.1_23521001_2 - 0.038 13.4 0.0 7.3 6.1 0.0 2.4 2 0 0 2 2 2 0 Cotton fibre expressed protein Trypsin PF00089.24 213586.1_23528001_1 - 7.9e-57 192.5 0.0 1.2e-56 191.9 0.0 1.2 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 213586.1_23528001_1 - 2e-48 163.2 0.8 2.2e-28 98.7 0.1 2.5 2 0 0 2 2 2 2 CUB domain Sushi PF00084.18 213586.1_23528001_1 - 3.4e-15 56.3 18.3 3.6e-09 37.0 0.3 4.2 5 0 0 5 5 5 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.4 213586.1_23528001_1 - 2.9e-08 33.7 10.8 8.7e-08 32.2 8.3 2.7 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 213586.1_23528001_1 - 3.8e-05 23.7 9.8 4.6e-05 23.4 7.9 2.2 2 0 0 2 2 2 1 Calcium-binding EGF domain CUB_2 PF02408.18 213586.1_23528001_1 - 7.6e-05 22.3 0.1 0.027 14.1 0.0 2.8 3 0 0 3 3 3 2 CUB-like domain Trypsin_2 PF13365.4 213586.1_23528001_1 - 9.4e-05 23.2 0.0 0.00018 22.3 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain cEGF PF12662.5 213586.1_23528001_1 - 0.0015 18.3 6.5 0.0066 16.2 3.9 2.8 2 0 0 2 2 2 1 Complement Clr-like EGF-like DUF1986 PF09342.9 213586.1_23528001_1 - 0.044 14.0 0.0 0.091 13.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Nucleoporin_FG2 PF15967.3 001030829.1_23528001_1 - 0 1031.1 66.3 0 1030.8 66.3 1.0 1 0 0 1 1 1 1 Nucleoporin FG repeated region Tox-ODYAM1 PF15642.4 001030829.1_23528001_1 - 0.028 13.3 6.5 0.04 12.7 6.5 1.1 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus DUF342 PF03961.11 001030829.1_23528001_1 - 0.029 12.9 5.2 0.14 10.6 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF342) PHM7_cyt PF14703.4 001030829.1_23528001_1 - 1.4 9.0 7.2 9.9 6.2 7.2 2.1 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter DUF1043 PF06295.10 001030829.1_23528001_1 - 1.5 8.7 9.2 7.6 6.4 1.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) DUF1664 PF07889.10 001030829.1_23528001_1 - 6.7 6.6 7.0 13 5.7 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Sec23_trunk PF04811.13 001031135.1_23529001_2 - 3.2e-85 285.5 0.1 5.6e-85 284.6 0.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.13 001031135.1_23529001_2 - 9.2e-27 92.7 2.6 2.5e-26 91.3 2.6 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.10 001031135.1_23529001_2 - 4.1e-21 75.4 0.0 9.5e-21 74.2 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.13 001031135.1_23529001_2 - 1.1e-14 54.0 5.2 2.7e-14 52.8 5.2 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.20 001031135.1_23529001_2 - 8.4e-11 41.5 0.0 1.7e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Sen15 PF09631.8 001031135.1_23529001_2 - 0.11 12.7 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 Sen15 protein Deltaretro_Tax PF05599.9 001031135.1_23529001_2 - 4.1 7.8 6.1 1.2 9.6 2.0 2.2 2 0 0 2 2 2 0 Deltaretrovirus Tax protein Sugar_tr PF00083.22 204375.1_23523001_1 - 1.6e-99 333.7 22.5 2.1e-99 333.3 22.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 204375.1_23523001_1 - 2.8e-28 98.7 33.1 3.4e-28 98.4 28.0 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.11 204375.1_23523001_1 - 3.7e-05 22.2 2.5 6.7e-05 21.4 2.5 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) ER_lumen_recept PF00810.16 001012996.1_23524001_2 - 2.8e-53 180.6 10.9 2.8e-53 180.6 10.9 1.7 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.12 001012996.1_23524001_2 - 0.0028 17.3 3.3 0.36 10.5 0.2 2.8 2 0 0 2 2 2 2 PQ loop repeat ING PF12998.5 001031312.1_23522001_3 - 2.6e-33 114.5 6.0 4.2e-33 113.8 6.0 1.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.27 001031312.1_23522001_3 - 0.0035 17.1 3.4 0.0076 16.0 3.4 1.6 1 0 0 1 1 1 1 PHD-finger Spc7 PF08317.9 001031312.1_23522001_3 - 0.0062 15.3 7.6 0.0076 15.0 7.6 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein zf-HC5HC2H PF13771.4 001031312.1_23522001_3 - 0.0092 16.1 0.2 0.027 14.6 0.0 1.8 2 0 0 2 2 2 1 PHD-like zinc-binding domain DUF2226 PF09987.7 001031312.1_23522001_3 - 0.037 13.2 0.2 0.049 12.8 0.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2226) RRF PF01765.17 001031312.1_23522001_3 - 0.061 13.1 1.4 0.089 12.6 1.4 1.2 1 0 0 1 1 1 0 Ribosome recycling factor DUF1192 PF06698.9 001031312.1_23522001_3 - 0.73 9.8 5.9 1.1 9.2 0.9 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) DEAD PF00270.27 001030725.2_23525001_1 - 3.2e-37 127.9 0.0 5.3e-37 127.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001030725.2_23525001_1 - 6.3e-30 103.7 0.1 5.4e-29 100.7 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 001030725.2_23525001_1 - 1.8e-05 24.7 0.8 3.5e-05 23.7 0.0 1.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HEM4 PF02602.13 001030725.2_23525001_1 - 0.016 14.5 0.1 0.027 13.7 0.1 1.3 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD Helicase_C_2 PF13307.4 001030725.2_23525001_1 - 0.027 14.5 0.0 0.059 13.4 0.0 1.5 1 0 0 1 1 1 0 Helicase C-terminal domain AAA_19 PF13245.4 001030725.2_23525001_1 - 0.07 13.3 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain EF-hand_4 PF12763.5 001031040.1_23527001_3 - 1.6e-18 66.4 0.1 4.7e-18 64.9 0.0 1.8 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EHD_N PF16880.3 001031040.1_23527001_3 - 4.4e-18 64.7 4.6 9.4e-18 63.7 4.6 1.6 1 0 0 1 1 1 1 N-terminal EH-domain containing protein Dynamin_N PF00350.21 001031040.1_23527001_3 - 6.9e-12 45.6 0.0 2.6e-11 43.7 0.0 1.9 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.21 001031040.1_23527001_3 - 1.4e-08 34.7 0.0 2.5e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase EF-hand_1 PF00036.30 001031040.1_23527001_3 - 0.0017 17.6 0.2 0.0055 16.0 0.2 1.9 1 0 0 1 1 1 1 EF hand AIG1 PF04548.14 001031040.1_23527001_3 - 0.046 12.9 0.0 0.14 11.3 0.0 1.7 2 0 0 2 2 2 0 AIG1 family Gtr1_RagA PF04670.10 001031040.1_23527001_3 - 0.056 12.7 0.0 0.24 10.6 0.0 1.8 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Roc PF08477.11 001031040.1_23527001_3 - 0.062 13.4 0.1 3.8 7.6 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.25 001031040.1_23527001_3 - 0.063 12.7 0.0 0.37 10.2 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_28 PF13521.4 001031040.1_23527001_3 - 0.13 12.4 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Xylo_C PF12529.6 001001785.1_23526001_1 - 1.1e-69 233.6 0.0 1.7e-69 233.0 0.0 1.3 1 0 0 1 1 1 1 Xylosyltransferase C terminal Branch PF02485.19 001001785.1_23526001_1 - 1.1e-54 185.4 1.9 1.5e-54 185.0 1.9 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme GAS2 PF02187.15 001199470.1_23525001_1 - 3.9e-27 94.0 0.1 6.7e-27 93.2 0.1 1.4 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain CH PF00307.29 001199470.1_23525001_1 - 1.9e-13 50.4 0.0 2.8e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain Ras PF00071.20 001044636.1_23524001_1 - 7.4e-37 126.3 0.0 1.1e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001044636.1_23524001_1 - 4e-12 46.3 0.0 6.2e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001044636.1_23524001_1 - 1.2e-06 28.0 0.0 2e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001044636.1_23524001_1 - 0.0013 18.2 0.0 0.0086 15.5 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.8 001044636.1_23524001_1 - 0.031 13.6 0.0 0.048 12.9 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.9 001044636.1_23524001_1 - 0.19 10.7 0.0 0.4 9.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Kelch_1 PF01344.23 001277820.1_23526001_1 - 1.2e-86 283.9 27.9 2.1e-16 59.1 1.9 6.6 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.4 001277820.1_23526001_1 - 9e-41 136.7 4.8 1.5e-07 31.3 0.0 6.4 4 2 2 6 6 6 6 Kelch motif BACK PF07707.13 001277820.1_23526001_1 - 6.6e-35 119.2 1.5 1.5e-34 118.1 1.5 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 001277820.1_23526001_1 - 8.4e-32 109.6 0.1 1.7e-31 108.5 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.4 001277820.1_23526001_1 - 7.7e-31 105.6 16.4 1.1e-05 25.5 0.3 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.13 001277820.1_23526001_1 - 1.1e-28 98.0 11.2 5.2e-05 22.9 0.2 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.4 001277820.1_23526001_1 - 4.2e-25 87.3 5.6 0.00061 19.6 0.1 6.4 4 1 2 6 6 6 5 Galactose oxidase, central domain PQQ_3 PF13570.4 001277820.1_23526001_1 - 0.0092 16.3 11.8 0.85 10.1 0.0 4.9 5 0 0 5 5 5 1 PQQ-like domain Kelch_5 PF13854.4 001277820.1_23526001_1 - 0.027 14.3 18.5 1.9 8.5 0.2 4.9 5 0 0 5 5 5 0 Kelch motif zf-RING_6 PF14835.4 001031246.1_23527001_1 - 4.4e-30 103.2 3.1 4.4e-30 103.2 3.1 2.7 3 0 0 3 3 3 1 zf-RING of BARD1-type protein Ank_4 PF13637.4 001031246.1_23527001_1 - 5.2e-24 84.2 2.9 3.6e-11 43.2 0.1 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 001031246.1_23527001_1 - 1.9e-23 82.0 2.0 7.4e-10 38.8 0.1 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 001031246.1_23527001_1 - 5e-23 81.4 2.0 2.9e-19 69.3 0.7 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 001031246.1_23527001_1 - 1e-18 66.7 5.1 6e-05 23.2 0.1 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.4 001031246.1_23527001_1 - 2.3e-16 58.1 0.4 0.00021 21.3 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat BRCT_2 PF16589.3 001031246.1_23527001_1 - 1.5e-11 44.4 0.2 3.4e-08 33.6 0.0 2.6 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.24 001031246.1_23527001_1 - 2.5e-10 40.5 0.1 4.3e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain zf-RING_5 PF14634.4 001031246.1_23527001_1 - 0.00011 22.0 6.5 0.00048 19.9 6.5 2.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.23 001031246.1_23527001_1 - 0.00023 20.8 3.3 0.0011 18.7 3.3 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001031246.1_23527001_1 - 0.00054 19.6 5.6 0.00054 19.6 5.6 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) NIBRIN_BRCT_II PF16508.3 001031246.1_23527001_1 - 0.0023 18.1 0.7 0.01 16.0 0.0 2.1 2 0 0 2 2 2 1 Second BRCT domain on Nijmegen syndrome breakage protein Prok-RING_4 PF14447.4 001031246.1_23527001_1 - 0.0024 17.6 8.3 0.012 15.3 8.3 2.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.4 001031246.1_23527001_1 - 0.0037 17.3 3.8 0.0037 17.3 3.8 3.2 2 1 0 2 2 1 1 zinc finger of C3HC4-type, RING PTCB-BRCT PF12738.5 001031246.1_23527001_1 - 0.0056 16.5 0.1 0.016 15.0 0.0 1.8 2 0 0 2 2 2 1 twin BRCT domain zf-RING_UBOX PF13445.4 001031246.1_23527001_1 - 0.0087 15.9 4.0 0.052 13.5 4.0 2.4 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 001031246.1_23527001_1 - 0.28 11.3 11.1 0.18 12.0 7.4 2.9 2 0 0 2 2 1 0 Ring finger domain Sulfotransfer_1 PF00685.25 001282522.1_23524001_2 - 2.1e-25 89.6 0.4 3e-25 89.1 0.4 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001282522.1_23524001_2 - 1.4e-16 61.4 1.6 8.7e-10 39.2 0.0 3.0 2 1 1 3 3 3 2 Sulfotransferase family PUF PF00806.17 001039292.1_23527001_1 - 2e-74 241.1 8.9 1e-09 37.4 0.0 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.9 001039292.1_23527001_1 - 0.013 15.7 1.1 4.2 7.6 0.1 3.9 1 1 3 4 4 4 0 CPL (NUC119) domain sCache_2 PF17200.2 001039292.1_23527001_1 - 0.038 13.7 0.1 30 4.3 0.0 4.0 4 0 0 4 4 4 0 Single Cache domain 2 Mt_ATP-synt_B PF05405.12 001039292.1_23527001_1 - 4.1 6.9 6.0 9.6 5.7 0.1 3.2 3 1 0 3 3 3 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) ANAPC4_WD40 PF12894.5 001030632.1_23524001_3 - 3.9e-12 46.2 0.3 0.0029 17.7 0.0 4.1 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 001030632.1_23524001_3 - 4.9e-10 39.7 24.4 4.8e-05 23.9 0.2 6.9 8 0 0 8 8 8 3 WD domain, G-beta repeat eIF2A PF08662.9 001030632.1_23524001_3 - 0.00017 21.4 0.6 0.16 11.7 0.1 3.2 3 1 2 5 5 5 2 Eukaryotic translation initiation factor eIF2A Rax2 PF12768.5 001030632.1_23524001_3 - 0.016 14.7 0.4 2.4 7.5 0.1 2.4 2 0 0 2 2 2 0 Cortical protein marker for cell polarity zf-CCCH_3 PF15663.3 001012573.4_23529001_3 - 0.00022 21.3 10.3 0.055 13.6 1.6 2.7 2 0 0 2 2 2 2 Zinc-finger containing family Torus PF16131.3 001012573.4_23529001_3 - 0.029 14.9 18.2 0.25 11.9 0.2 4.5 2 2 2 4 4 4 0 Torus domain zf-CCCH_2 PF14608.4 001012573.4_23529001_3 - 0.04 14.3 25.2 3.7 8.0 0.8 5.4 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger ELMO_CED12 PF04727.11 001277915.1_23524001_3 - 1e-50 172.2 0.7 1.8e-50 171.4 0.7 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family Pkinase PF00069.23 204246.1_23525001_3 - 9.1e-36 123.4 0.0 1.4e-35 122.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 204246.1_23525001_3 - 1.6e-34 119.2 0.0 2.2e-34 118.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TGF_beta_GS PF08515.10 204246.1_23525001_3 - 4.2e-17 61.2 0.4 8e-17 60.3 0.4 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.21 204246.1_23525001_3 - 8.7e-09 36.2 7.0 8.7e-09 36.2 7.0 1.9 2 0 0 2 2 2 1 Activin types I and II receptor domain APH PF01636.21 204246.1_23525001_3 - 0.018 14.8 0.0 0.033 14.0 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family NAD_binding_1 PF00175.19 001199638.1_23523001_1 - 1.1e-07 32.3 0.0 2.4e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Ski_Sno PF02437.15 205174.2_23527001_3 - 4.7e-44 148.5 2.0 1.1e-43 147.2 2.0 1.7 1 0 0 1 1 1 1 SKI/SNO/DAC family c-SKI_SMAD_bind PF08782.8 205174.2_23527001_3 - 5.6e-36 122.5 4.1 1.5e-35 121.1 4.1 1.8 1 0 0 1 1 1 1 c-SKI Smad4 binding domain DUF489 PF04356.10 205174.2_23527001_3 - 0.04 13.8 9.8 0.027 14.3 7.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF489) GCM PF03615.13 206980.1_23524001_3 - 6.1e-70 233.4 4.6 1.1e-69 232.5 4.6 1.5 1 0 0 1 1 1 1 GCM motif protein UPA PF17217.1 001031225.2_23527001_3 - 4.4e-72 240.6 0.0 7.4e-72 239.8 0.0 1.4 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.18 001031225.2_23527001_3 - 2.2e-31 108.0 0.0 5.1e-31 106.8 0.0 1.7 1 0 0 1 1 1 1 ZU5 domain Death PF00531.20 001031225.2_23527001_3 - 1.8e-14 53.5 0.7 4.2e-14 52.3 0.1 1.9 2 0 0 2 2 2 1 Death domain I-set PF07679.14 001031225.2_23527001_3 - 6.6e-12 45.2 0.1 2.1e-09 37.2 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 001031225.2_23527001_3 - 2.3e-11 44.0 0.0 8.8e-08 32.5 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain TSP_1 PF00090.17 001031225.2_23527001_3 - 1.6e-10 40.9 28.6 2.7e-07 30.5 10.5 2.9 2 0 0 2 2 2 2 Thrombospondin type 1 domain ig PF00047.23 001031225.2_23527001_3 - 1.5e-06 28.1 0.0 2.7e-05 24.1 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001031225.2_23527001_3 - 2.3e-05 24.5 0.0 0.00072 19.7 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Glycos_transf_2 PF00535.24 001031578.1_23527001_2 - 1.7e-34 119.0 0.0 2.6e-34 118.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 001031578.1_23527001_2 - 7.2e-24 84.3 0.0 1.7e-23 83.1 0.0 1.7 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.12 001031578.1_23527001_2 - 1.2e-07 31.1 0.0 3.7e-07 29.6 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase RicinB_lectin_2 PF14200.4 001031578.1_23527001_2 - 0.00014 22.4 0.1 0.95 10.1 0.0 2.5 2 0 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Glyco_tranf_2_2 PF10111.7 001031578.1_23527001_2 - 0.00043 19.7 0.0 0.001 18.4 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 COX6A PF02046.13 001277510.1_23522001_2 - 2.9e-15 56.6 0.0 5.8e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa 7tm_2 PF00002.22 001163650.1_23523001_1 - 1.6e-80 269.8 19.0 2.3e-80 269.3 19.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001163650.1_23523001_1 - 1.6e-18 66.6 8.1 2.9e-18 65.8 8.1 1.5 1 0 0 1 1 1 1 Hormone receptor domain DUF2070 PF09843.7 001163650.1_23523001_1 - 1.3 7.1 9.3 2.2 6.3 9.3 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) RNA_pol_Rbc25 PF08292.10 001277374.1_23524001_2 - 4e-43 146.6 0.1 6.5e-43 145.9 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.15 001277374.1_23524001_2 - 2.1e-19 69.5 0.0 4.2e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 LYRIC PF15686.3 001277374.1_23524001_3 - 0.065 12.6 2.5 0.095 12.1 2.5 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Clat_adaptor_s PF01217.18 001291736.1_23522001_3 - 8.6e-23 80.7 3.9 1.2e-17 64.0 2.1 2.1 1 1 1 2 2 2 2 Clathrin adaptor complex small chain Arm PF00514.21 001193575.1_23529001_1 - 1.3e-83 272.6 15.5 2.5e-12 46.2 0.3 9.2 8 1 1 9 9 9 8 Armadillo/beta-catenin-like repeat Arm_3 PF16186.3 001193575.1_23529001_1 - 5.5e-23 80.1 2.9 2.7e-22 77.9 3.4 1.9 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.4 001193575.1_23529001_1 - 8.4e-23 80.3 1.2 2.6e-08 34.0 0.3 6.3 5 1 1 6 6 6 5 HEAT-like repeat IBB PF01749.18 001193575.1_23529001_1 - 4.2e-22 78.2 4.0 8.1e-22 77.3 4.0 1.5 1 0 0 1 1 1 1 Importin beta binding domain HEAT_2 PF13646.4 001193575.1_23529001_1 - 4.7e-15 55.6 0.2 3e-06 27.4 0.0 5.5 2 2 2 5 5 5 3 HEAT repeats HEAT PF02985.20 001193575.1_23529001_1 - 5.1e-15 54.1 5.4 0.0074 16.3 0.0 6.1 6 0 0 6 6 6 3 HEAT repeat Atx10homo_assoc PF09759.7 001193575.1_23529001_1 - 0.00013 21.9 0.8 2 8.4 0.0 4.4 2 1 2 4 4 4 1 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_C PF11698.6 001193575.1_23529001_1 - 0.0017 18.3 0.9 2.8 7.9 0.1 3.8 4 0 0 4 4 4 1 V-ATPase subunit H Arm_2 PF04826.11 001193575.1_23529001_1 - 0.0025 17.2 0.8 4.8 6.4 0.2 3.8 2 1 2 4 4 4 1 Armadillo-like SecY PF00344.18 001321620.1_23525001_3 - 4e-77 259.3 13.0 5.4e-77 258.9 13.0 1.2 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.7 001321620.1_23525001_3 - 1e-18 66.7 0.2 3.7e-18 64.9 0.2 2.1 1 0 0 1 1 1 1 Plug domain of Sec61p DUF2975 PF11188.6 001321620.1_23525001_3 - 8.6 6.1 11.9 0.12 12.1 1.6 3.1 3 1 1 4 4 4 0 Protein of unknown function (DUF2975) zf-A20 PF01754.14 001277522.1_23524001_1 - 2.3e-12 46.5 8.8 9.2e-12 44.6 8.8 2.2 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.14 001277522.1_23524001_1 - 8.9e-09 35.3 7.6 8.9e-09 35.3 7.6 2.7 2 0 0 2 2 2 1 AN1-like Zinc finger Apt1 PF10351.7 001277522.1_23524001_2 - 0.13 10.9 0.1 0.17 10.6 0.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Lectin_C PF00059.19 001277527.1_23522001_2 - 2.4e-17 63.5 0.7 3.3e-17 63.1 0.7 1.2 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 001277527.1_23522001_2 - 0.00048 19.7 3.0 0.00089 18.8 2.2 2.0 1 1 1 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like EI24 PF07264.9 001277527.1_23522001_2 - 0.084 13.0 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) RasGEF PF00617.17 001277274.1_23525001_1 - 7.2e-52 175.9 0.2 1.3e-51 175.1 0.2 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.18 001277274.1_23525001_1 - 2.8e-14 53.1 0.1 7.2e-14 51.8 0.1 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif FYVE PF01363.19 001199686.1_23529001_3 - 3.5e-29 100.6 25.3 3.3e-16 59.0 11.3 6.2 5 1 1 6 6 6 2 FYVE zinc finger AIG1 PF04548.14 001199686.1_23529001_3 - 0.0066 15.7 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 AIG1 family GBP PF02263.17 001199686.1_23529001_3 - 0.0091 15.2 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain HSP70 PF00012.18 001159698.1_23527001_1 - 2.9e-186 620.1 7.2 2.4e-185 617.1 2.3 2.8 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.11 001159698.1_23527001_1 - 2.2e-05 23.3 0.0 5.6e-05 22.0 0.0 1.6 1 1 0 1 1 1 1 MreB/Mbl protein HSP20 PF00011.19 001010842.2_23522001_2 - 4.9e-16 58.6 0.0 8e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family NBP1 PF08537.8 001010842.2_23522001_2 - 0.027 13.8 0.2 0.039 13.2 0.2 1.1 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 DUF3540 PF12059.6 001010842.2_23522001_2 - 0.051 13.2 2.5 0.28 10.8 1.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3540) DUF755 PF05501.9 001010842.2_23522001_2 - 1.2 9.3 8.2 4.7 7.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF755) SSP160 PF06933.9 001010842.2_23522001_2 - 1.9 6.4 16.8 2.7 5.9 16.8 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FSA_C PF10479.7 001010842.2_23522001_2 - 8.4 4.2 9.7 11 3.8 9.7 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Zip PF02535.20 001010842.2_23522001_3 - 0.68 9.0 1.8 0.76 8.8 1.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.15 001010842.2_23522001_3 - 1.9 7.0 5.2 2.2 6.8 5.2 1.1 1 0 0 1 1 1 0 Presenilin Activator_LAG-3 PF11498.6 001010842.2_23522001_3 - 5.4 5.7 30.5 7.2 5.3 30.5 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TFIIA PF03153.11 001010842.2_23522001_3 - 8.9 6.1 24.2 14 5.4 24.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FtsJ PF01728.17 001277545.1_23523001_3 - 9e-53 178.9 0.0 1.1e-52 178.5 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.4 001277545.1_23523001_3 - 0.0039 16.9 0.0 0.13 11.9 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Lectin_C PF00059.19 001039166.1_23522001_3 - 1.1e-16 61.3 0.1 1.5e-16 60.9 0.1 1.2 1 0 0 1 1 1 1 Lectin C-type domain EMP24_GP25L PF01105.22 001319030.1_23526001_2 - 1.1e-48 165.4 0.3 1.6e-48 165.0 0.3 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD CSF-1 PF05337.9 001193295.1_23522001_1 - 1.6e-18 67.1 2.7 2.3e-18 66.5 2.7 1.2 1 0 0 1 1 1 1 Macrophage colony stimulating factor-1 (CSF-1) ETRAMP PF09716.8 001193295.1_23522001_1 - 0.35 10.8 2.0 3.2 7.8 0.2 2.5 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF4834 PF16118.3 001031031.1_23529001_2 - 0.27 12.1 1.8 1.1 10.1 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) OAD_gamma PF04277.11 001031031.1_23529001_2 - 0.72 10.4 8.7 3.8 8.0 0.9 4.0 4 0 0 4 4 4 0 Oxaloacetate decarboxylase, gamma chain DUF788 PF05620.9 001031031.1_23529001_2 - 0.97 9.2 4.8 2 8.2 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF788) zf-C2H2 PF00096.24 001031031.1_23529001_3 - 9.5e-25 85.5 55.3 1.1e-05 25.5 2.8 7.9 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001031031.1_23529001_3 - 4.5e-12 45.7 61.4 6.1e-07 29.5 1.2 9.9 10 0 0 10 10 10 4 Zinc-finger double domain zf-H2C2_5 PF13909.4 001031031.1_23529001_3 - 6.2e-08 32.1 22.8 0.00019 21.0 3.9 4.5 3 0 0 3 3 3 2 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.4 001031031.1_23529001_3 - 1.1e-07 32.0 70.9 0.0041 17.7 1.3 8.7 8 0 0 8 8 8 6 C2H2-type zinc finger DUF3268 PF11672.6 001031031.1_23529001_3 - 0.0024 18.1 15.2 0.023 14.9 1.3 2.5 2 0 0 2 2 2 2 zinc-finger-containing domain GAGA PF09237.9 001031031.1_23529001_3 - 0.2 11.4 6.0 5.5 6.8 0.3 2.9 2 0 0 2 2 2 0 GAGA factor DUF4834 PF16118.3 001031031.1_23529001_3 - 0.22 12.4 4.6 3.5 8.5 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) zf-C2H2_7 PF15269.4 001031031.1_23529001_3 - 0.25 11.3 16.9 0.51 10.3 2.0 3.9 2 1 1 3 3 3 0 Zinc-finger RNA_pol_3_Rpc31 PF11705.6 001031031.1_23529001_3 - 0.39 10.8 15.3 0.15 12.2 7.8 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Astro_capsid_p PF12226.6 001031031.1_23529001_3 - 1.1 8.2 6.0 1.7 7.5 6.0 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Sec2p PF06428.9 001199639.1_23524001_1 - 1.9e-08 34.0 9.6 1.9e-08 34.0 9.6 1.9 1 1 1 2 2 2 1 GDP/GTP exchange factor Sec2p IATP PF04568.10 001199639.1_23524001_1 - 0.028 14.7 2.2 0.091 13.1 1.6 2.1 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP HAUS-augmin3 PF14932.4 001199639.1_23524001_1 - 0.028 13.8 8.8 0.044 13.2 8.8 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF2408 PF10303.7 001199639.1_23524001_1 - 0.064 13.7 3.9 0.13 12.7 3.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) APG6 PF04111.10 001199639.1_23524001_1 - 0.41 9.8 12.2 0.59 9.3 12.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Spc7 PF08317.9 001199639.1_23524001_1 - 0.61 8.8 14.1 0.9 8.2 14.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2203 PF09969.7 001199639.1_23524001_1 - 1.2 9.8 6.7 2.8 8.6 6.7 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) IncA PF04156.12 001199639.1_23524001_1 - 1.6 8.3 10.4 2.7 7.6 10.4 1.3 1 0 0 1 1 1 0 IncA protein HSP70 PF00012.18 001199639.1_23524001_1 - 1.8 6.5 7.5 2.7 5.9 7.5 1.2 1 0 0 1 1 1 0 Hsp70 protein Exonuc_VII_L PF02601.13 001199639.1_23524001_1 - 1.9 7.9 5.3 2.6 7.4 5.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit OmpH PF03938.12 001199639.1_23524001_1 - 3.8 7.4 11.4 6.5 6.6 11.4 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Pyridoxal_deC PF00282.17 204913.1_23527001_1 - 3e-151 503.3 0.0 3.6e-151 503.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 204913.1_23527001_1 - 7.7e-05 21.7 0.0 0.00039 19.4 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.19 204913.1_23527001_1 - 9.1e-05 21.7 0.0 0.00015 21.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.11 204913.1_23527001_1 - 0.016 13.8 0.0 0.026 13.1 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS DegT_DnrJ_EryC1 PF01041.15 204913.1_23527001_1 - 0.035 13.3 0.0 0.05 12.8 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family OKR_DC_1 PF01276.18 204913.1_23527001_1 - 0.073 11.7 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain PRELI PF04707.12 001031011.1_23525001_2 - 1.3e-51 174.4 0.0 1.7e-51 174.0 0.0 1.1 1 0 0 1 1 1 1 PRELI-like family FKBP_C PF00254.26 001006250.1_23525001_3 - 6.1e-48 161.0 0.0 1.4e-30 105.4 0.0 2.3 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.26 001006250.1_23525001_3 - 3.1e-16 58.3 10.1 9.4e-09 34.6 1.1 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.15 001006250.1_23525001_3 - 9e-14 50.3 8.8 1.8e-05 24.4 0.8 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.4 001006250.1_23525001_3 - 3e-07 30.5 1.7 0.0098 16.3 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 001006250.1_23525001_3 - 2.1e-05 24.6 2.6 6.5e-05 23.0 1.2 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.4 001006250.1_23525001_3 - 2.2e-05 23.9 4.6 0.002 17.6 0.1 3.3 3 1 1 4 4 4 1 TPR repeat TPR_19 PF14559.4 001006250.1_23525001_3 - 2.7e-05 24.5 0.7 0.026 14.9 0.3 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 001006250.1_23525001_3 - 0.0001 22.1 12.0 0.0012 18.7 0.7 4.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.4 001006250.1_23525001_3 - 0.00019 21.9 0.4 0.01 16.4 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat PknG_TPR PF16918.3 001006250.1_23525001_3 - 0.0012 17.6 0.3 0.0018 16.9 0.3 1.2 1 0 0 1 1 1 1 Protein kinase G tetratricopeptide repeat Fis1_TPR_C PF14853.4 001006250.1_23525001_3 - 0.0038 17.1 0.2 0.0038 17.1 0.2 2.7 2 1 1 3 3 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.4 001006250.1_23525001_3 - 0.0042 16.9 4.1 0.13 12.2 0.3 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.4 001006250.1_23525001_3 - 0.0075 16.3 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.4 001006250.1_23525001_3 - 0.008 16.8 0.1 0.49 11.2 0.0 3.0 2 1 1 3 3 2 1 Tetratricopeptide repeat DUF3856 PF12968.5 001006250.1_23525001_3 - 0.018 15.0 0.4 0.037 14.0 0.4 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) TPR_17 PF13431.4 001006250.1_23525001_3 - 0.071 13.4 1.7 4.3 7.8 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat GDPD PF03009.15 001006250.1_23525001_3 - 0.097 12.2 0.1 0.2 11.2 0.1 1.4 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family ANAPC3 PF12895.5 001006250.1_23525001_3 - 0.35 11.0 7.6 3 8.0 3.7 2.9 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 RabGAP-TBC PF00566.16 001252314.1_23524001_2 - 6.2e-50 169.7 0.0 6.2e-50 169.7 0.0 1.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DUF5051 PF16473.3 001252314.1_23524001_3 - 0.24 11.2 2.1 0.37 10.6 2.1 1.2 1 0 0 1 1 1 0 3' exoribonuclease, RNase T-like Peptidase_M10 PF00413.22 001278089.1_23524001_3 - 1.1e-61 207.2 0.0 1.9e-61 206.4 0.0 1.4 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 001278089.1_23524001_3 - 1.4e-44 149.7 10.3 1.1e-13 50.8 0.0 4.5 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 001278089.1_23524001_3 - 2.2e-12 46.8 0.0 4.5e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 001278089.1_23524001_3 - 0.011 15.2 0.1 3.8 7.0 0.2 2.3 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.4 001278089.1_23524001_3 - 0.02 15.3 0.4 0.042 14.2 0.4 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.3 001278089.1_23524001_3 - 0.052 12.6 0.1 0.11 11.6 0.1 1.5 1 0 0 1 1 1 0 Met-zincin Reprolysin_5 PF13688.4 001278089.1_23524001_3 - 0.079 13.0 0.3 0.14 12.2 0.3 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_4 PF13583.4 001278089.1_23524001_3 - 0.17 11.4 0.0 0.37 10.3 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.6 001278089.1_23524001_3 - 0.2 11.1 0.1 0.42 10.0 0.1 1.5 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Troponin PF00992.18 205114.1_23522001_3 - 3.6e-39 134.0 42.7 3.9e-31 108.0 28.3 3.1 2 1 1 3 3 3 2 Troponin Aldedh PF00171.20 001006223.1_23526001_2 - 3.5e-88 296.0 0.0 4.4e-88 295.7 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Rap_GAP PF02145.13 001277453.1_23529001_1 - 5.7e-48 162.8 0.0 1.2e-47 161.8 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP DUF837 PF05769.9 001277453.1_23529001_1 - 0.17 11.7 2.2 0.48 10.2 2.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF837) RNA_pol_Rpb2_6 PF00562.26 001006448.1_23528001_3 - 5e-128 427.3 0.2 7.3e-128 426.8 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.13 001006448.1_23528001_3 - 3.3e-68 229.1 0.1 7.1e-68 228.0 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.12 001006448.1_23528001_3 - 3.2e-56 189.9 0.0 9.1e-56 188.4 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.18 001006448.1_23528001_3 - 4.1e-34 116.7 1.5 7.6e-34 115.8 0.2 2.2 3 0 0 3 3 3 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.11 001006448.1_23528001_3 - 2.3e-24 85.3 0.8 5.6e-24 84.1 0.8 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.14 001006448.1_23528001_3 - 7.1e-24 83.6 0.0 1.7e-23 82.4 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.15 001006448.1_23528001_3 - 7e-19 68.0 0.4 1.7e-18 66.7 0.4 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Amidoligase_2 PF12224.6 001006448.1_23528001_3 - 0.022 14.3 0.0 0.037 13.5 0.0 1.3 1 0 0 1 1 1 0 Putative amidoligase enzyme Torsin PF06309.9 001030687.1_23525001_2 - 2.1e-51 173.2 0.3 3.1e-51 172.6 0.3 1.3 1 0 0 1 1 1 1 Torsin AAA PF00004.27 001030687.1_23525001_2 - 0.014 15.7 0.0 0.025 14.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) 2OG-FeII_Oxy_2 PF13532.4 001277496.1_23523001_1 - 4.1e-26 92.3 0.0 5.6e-26 91.9 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-C2H2 PF00096.24 001080872.1_23529001_3 - 8.9e-29 98.2 48.6 7.9e-05 22.8 0.6 8.1 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001080872.1_23529001_3 - 2.8e-24 83.6 55.8 0.0016 19.0 0.1 9.3 8 0 0 8 8 8 7 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001080872.1_23529001_3 - 1.1e-23 82.4 42.7 8.6e-07 29.0 1.2 8.5 8 0 0 8 8 8 5 Zinc-finger double domain zf-met PF12874.5 001080872.1_23529001_3 - 5.1e-17 61.5 36.4 0.0078 16.4 0.3 8.2 7 0 0 7 7 7 6 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001080872.1_23529001_3 - 5.8e-16 58.2 29.9 0.0013 18.9 0.4 7.6 8 0 0 8 8 7 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001080872.1_23529001_3 - 0.00012 21.8 44.5 0.052 13.4 0.6 8.5 8 0 0 8 8 8 4 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001080872.1_23529001_3 - 0.0026 17.4 31.4 1.1 8.9 0.3 7.4 7 0 0 7 7 7 4 zinc-finger C2H2-type DUF3268 PF11672.6 001080872.1_23529001_3 - 0.011 16.0 11.1 0.27 11.4 0.2 3.3 3 0 0 3 3 3 0 zinc-finger-containing domain DUF2225 PF09986.7 001080872.1_23529001_3 - 0.13 11.8 1.2 0.56 9.8 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) BolA PF01722.16 001080872.1_23529001_3 - 0.15 12.2 3.5 12 6.2 0.0 3.4 3 0 0 3 3 3 0 BolA-like protein NinF PF05810.10 001080872.1_23529001_3 - 0.39 10.5 3.1 0.4 10.5 0.7 2.2 2 0 0 2 2 2 0 NinF protein zf-C2HC_2 PF13913.4 001080872.1_23529001_3 - 0.59 10.0 34.9 2.9 7.8 0.1 7.5 7 0 0 7 7 7 0 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.5 001080872.1_23529001_3 - 0.86 9.8 31.3 3.2 8.0 1.0 7.1 3 3 4 7 7 7 0 C2H2 type zinc-finger (2 copies) Desulfoferrod_N PF06397.10 001080872.1_23529001_3 - 2.8 7.5 13.4 1.2 8.7 0.5 4.4 4 0 0 4 4 4 0 Desulfoferrodoxin, N-terminal domain Jas PF16135.3 001080872.1_23529001_3 - 7.2 6.7 9.0 0.68 10.0 1.1 3.0 3 0 0 3 3 2 0 TPL-binding domain in jasmonate signalling Clathrin_lg_ch PF01086.15 001305576.1_23526001_2 - 1.4e-55 188.6 10.9 1.8e-55 188.3 10.9 1.1 1 0 0 1 1 1 1 Clathrin light chain GED PF02212.16 001305576.1_23526001_2 - 0.35 10.9 1.1 0.67 10.0 1.1 1.4 1 0 0 1 1 1 0 Dynamin GTPase effector domain Carb_anhydrase PF00194.19 001277411.1_23522001_3 - 8.2e-90 300.6 0.0 9.2e-90 300.5 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Mito_carr PF00153.25 204107.1_23524001_1 - 3.4e-64 212.7 0.3 6.3e-23 80.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Arrestin_N PF00339.27 001097533.1_23524001_3 - 6.1e-41 139.8 0.1 1.6e-37 128.7 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 001097533.1_23524001_3 - 7.7e-23 81.2 1.3 1.3e-22 80.5 1.3 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain BatD PF13584.4 001097533.1_23524001_3 - 0.0078 15.0 0.1 0.011 14.6 0.1 1.1 1 0 0 1 1 1 1 Oxygen tolerance CBM49 PF09478.8 001097533.1_23524001_3 - 0.16 12.1 0.9 0.29 11.3 0.9 1.3 1 0 0 1 1 1 0 Carbohydrate binding domain CBM49 Pkinase_Tyr PF07714.15 001030365.1_23529001_3 - 1.5e-91 306.1 0.0 2.6e-91 305.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 001030365.1_23529001_3 - 9.8e-59 196.2 3.8 7.3e-30 103.2 0.2 2.5 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.4 001030365.1_23529001_3 - 7.4e-53 177.7 82.0 5.4e-47 158.8 28.6 3.9 2 1 1 3 3 3 3 Growth factor receptor domain IV Pkinase PF00069.23 001030365.1_23529001_3 - 1.4e-39 135.9 0.0 2.2e-39 135.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.18 001030365.1_23529001_3 - 1.3e-34 119.1 88.5 1.1e-28 99.9 42.3 4.2 2 1 2 4 4 4 3 Furin-like cysteine rich region APH PF01636.21 001030365.1_23529001_3 - 0.014 15.2 0.1 0.023 14.5 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.4 001030365.1_23529001_3 - 0.024 13.8 0.0 0.051 12.7 0.0 1.5 1 0 0 1 1 1 0 Kinase-like DUF3951 PF13131.4 001030365.1_23529001_3 - 0.16 12.1 1.6 0.35 11.0 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3951) zf-CCCH_3 PF15663.3 001163338.3_23529001_3 - 0.00022 21.3 10.3 0.055 13.6 1.6 2.7 2 0 0 2 2 2 2 Zinc-finger containing family Torus PF16131.3 001163338.3_23529001_3 - 0.03 14.9 18.2 0.25 11.9 0.2 4.5 2 2 2 4 4 4 0 Torus domain zf-CCCH_2 PF14608.4 001163338.3_23529001_3 - 0.041 14.2 25.2 3.7 8.0 0.8 5.4 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger A_deamin PF02137.16 004440.1_23529120_2 - 7.5e-117 390.3 0.0 9.5e-117 389.9 0.0 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.24 004440.1_23529120_2 - 2.7e-26 91.9 0.2 5.6e-13 49.2 0.1 2.5 2 0 0 2 2 2 2 Double-stranded RNA binding motif VGCC_beta4Aa_N PF12052.6 131210.1_23527120_1 - 1.2e-21 76.4 6.1 2.4e-21 75.4 6.1 1.6 1 0 0 1 1 1 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal SH3_1 PF00018.26 131210.1_23527120_1 - 0.0068 15.8 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 131210.1_23527120_1 - 0.028 14.1 0.0 0.053 13.3 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain SH3_2 PF07653.15 131210.1_23527120_1 - 0.068 12.7 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain Guanylate_kin PF00625.19 131210.1_23527120_2 - 1.5e-34 119.2 0.6 2e-34 118.7 0.6 1.2 1 0 0 1 1 1 1 Guanylate kinase E1-E2_ATPase PF00122.18 073529.2_23529120_3 - 6.3e-64 215.2 1.3 6.3e-64 215.2 1.3 2.4 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 073529.2_23529120_3 - 1.3e-45 155.2 2.4 3.7e-45 153.7 2.4 1.9 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 073529.2_23529120_3 - 9e-21 73.6 0.3 1.6e-20 72.8 0.3 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 073529.2_23529120_3 - 2e-17 64.1 0.0 3.7e-16 59.9 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 073529.2_23529120_3 - 1e-16 60.2 1.2 3e-16 58.7 0.2 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 073529.2_23529120_3 - 1.6e-05 24.6 0.6 3.3e-05 23.6 0.6 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 073529.2_23529120_3 - 0.0067 16.7 0.1 0.021 15.1 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase ATP-synt_C PF00137.19 102686.1_23522120_3 - 5.2e-11 42.6 12.4 7.6e-11 42.1 12.4 1.2 1 0 0 1 1 1 1 ATP synthase subunit C Filamin PF00630.17 001030341.2_23529001_2 - 0 1245.6 57.2 1.6e-20 73.7 0.1 24.2 24 0 0 24 24 24 24 Filamin/ABP280 repeat CH PF00307.29 001030341.2_23529001_2 - 1.5e-37 127.9 0.2 5.9e-20 71.4 0.2 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain Y_Y_Y PF07495.11 001030341.2_23529001_2 - 3.1e-16 58.9 22.9 0.47 10.3 0.0 14.2 15 0 0 15 15 15 5 Y_Y_Y domain Big_3_5 PF16640.3 001030341.2_23529001_2 - 5.1e-14 52.1 32.5 0.13 12.3 0.0 13.2 14 0 0 14 14 14 5 Bacterial Ig-like domain (group 3) DUF5060 PF16586.3 001030341.2_23529001_2 - 2.1e-11 43.8 1.1 1.7 8.9 0.0 11.5 14 0 0 14 14 14 1 Domain of unknown function (DUF5060) Invasin_D3 PF09134.8 001030341.2_23529001_2 - 2.8e-09 36.5 3.7 0.37 10.4 0.1 8.4 10 0 0 10 10 10 2 Invasin, domain 3 YtkA PF13115.4 001030341.2_23529001_2 - 8.7e-08 32.5 14.8 2.4 8.7 0.1 12.2 15 0 0 15 15 13 1 YtkA-like DUF2141 PF09912.7 001030341.2_23529001_2 - 6.4e-05 22.7 1.5 47 3.8 0.0 7.2 8 0 0 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2141) BatD PF13584.4 001030341.2_23529001_2 - 0.00041 19.2 1.6 1.2 7.9 0.0 3.8 5 0 0 5 5 5 2 Oxygen tolerance EMP24_GP25L PF01105.22 001030341.2_23529001_2 - 0.0013 18.6 0.1 48 3.7 0.0 6.4 8 0 0 8 8 8 0 emp24/gp25L/p24 family/GOLD PapC_N PF13954.4 001030341.2_23529001_2 - 0.026 14.4 0.0 8.3 6.2 0.0 4.9 6 0 0 6 6 6 0 PapC N-terminal domain PEGA PF08308.9 001030341.2_23529001_2 - 0.97 9.2 6.4 1.8e+02 2.0 0.3 7.1 7 0 0 7 7 7 0 PEGA domain Sema PF01403.17 204258.1_23525001_1 - 1e-146 488.9 0.0 1.3e-146 488.5 0.0 1.1 1 0 0 1 1 1 1 Sema domain Ig_3 PF13927.4 204258.1_23525001_1 - 1.2e-06 28.9 0.0 3.5e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 204258.1_23525001_1 - 1.8e-06 27.9 0.0 4.9e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 204258.1_23525001_1 - 1.6e-05 24.8 0.0 3.4e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.15 204258.1_23525001_1 - 3.1e-05 24.0 0.3 0.00086 19.3 0.3 2.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 204258.1_23525001_1 - 6.5e-05 23.1 0.0 0.00031 20.9 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain PSI PF01437.23 204258.1_23525001_1 - 0.0014 18.9 8.8 0.0041 17.5 8.8 1.8 1 0 0 1 1 1 1 Plexin repeat C2-set PF05790.13 204258.1_23525001_1 - 0.0071 16.4 0.0 0.018 15.1 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin C2-set domain IL6Ra-bind PF09240.8 001312662.1_23525001_1 - 4.7e-22 78.1 0.7 9.8e-22 77.1 0.1 1.9 2 0 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.8 001312662.1_23525001_1 - 0.01 15.9 0.1 0.01 15.9 0.1 2.2 2 0 0 2 2 2 0 Erythropoietin receptor, ligand binding 2-Hacid_dh_C PF02826.17 001030624.1_23529001_3 - 2.1e-55 186.7 0.0 2.8e-55 186.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 001030624.1_23529001_3 - 8.4e-26 90.1 0.0 1.1e-25 89.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 001030624.1_23529001_3 - 0.00071 19.6 0.0 0.0011 19.0 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IMPDH PF00478.23 001030998.1_23525001_2 - 2.1e-79 266.9 2.0 4.8e-79 265.7 2.0 1.5 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.16 001030998.1_23525001_2 - 0.00089 18.2 1.5 0.0014 17.6 1.5 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cupin_8 PF13621.4 001114659.1_23523001_1 - 2.9e-85 286.0 0.3 3.5e-85 285.7 0.3 1.0 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.20 001114659.1_23523001_1 - 0.0025 18.1 0.0 0.0048 17.2 0.0 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase Plexin_cytopl PF08337.10 001257265.1_23529001_2 - 6.1e-233 774.4 0.0 8.3e-233 773.9 0.0 1.2 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.17 001257265.1_23529001_2 - 3.3e-60 203.9 0.0 4.9e-60 203.4 0.0 1.3 1 0 0 1 1 1 1 Sema domain TIG PF01833.22 001257265.1_23529001_2 - 2e-30 104.6 9.2 2.2e-11 43.5 0.7 6.7 7 1 0 7 7 7 4 IPT/TIG domain PSI PF01437.23 001257265.1_23529001_2 - 5.7e-16 58.7 52.8 2.1e-08 34.5 15.7 3.6 3 0 0 3 3 3 3 Plexin repeat Caldesmon PF02029.13 001303036.1_23525001_1 - 5.3e-49 167.2 45.7 3e-37 128.4 25.2 2.8 1 1 2 3 3 3 3 Caldesmon V_ATPase_I PF01496.17 001303036.1_23525001_1 - 0.087 10.6 10.8 0.11 10.2 10.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RNA_pol_Rpb2_6 PF00562.26 001303036.1_23525001_1 - 2.6 6.8 6.3 4.2 6.2 6.3 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 6 Securin PF04856.11 001277740.1_23522001_2 - 7.6e-09 35.7 0.4 1.9e-08 34.4 0.4 1.6 1 1 0 1 1 1 1 Securin sister-chromatid separation inhibitor TspO_MBR PF03073.13 001278057.1_23523001_2 - 1.3e-48 164.3 13.1 1.8e-48 163.9 13.1 1.2 1 0 0 1 1 1 1 TspO/MBR family FGF PF00167.16 204399.1_23522001_1 - 3.6e-47 159.4 0.3 4.4e-47 159.1 0.3 1.1 1 0 0 1 1 1 1 Fibroblast growth factor TSC22 PF01166.16 001077234.1_23523001_1 - 1.1e-27 96.0 4.8 1.6e-27 95.5 4.8 1.2 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF972 PF06156.11 001077234.1_23523001_1 - 0.0015 18.9 3.3 0.0023 18.4 3.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF972) ZapB PF06005.10 001077234.1_23523001_1 - 0.013 15.8 4.7 0.022 15.1 4.7 1.3 1 0 0 1 1 1 0 Cell division protein ZapB DivIC PF04977.13 001077234.1_23523001_1 - 0.015 14.9 2.5 0.026 14.1 2.5 1.3 1 0 0 1 1 1 0 Septum formation initiator K-box PF01486.15 001077234.1_23523001_1 - 0.028 14.5 2.4 0.046 13.8 2.4 1.3 1 0 0 1 1 1 0 K-box region Fzo_mitofusin PF04799.11 001077234.1_23523001_1 - 0.15 11.4 1.2 0.24 10.8 1.2 1.3 1 0 0 1 1 1 0 fzo-like conserved region bZIP_2 PF07716.13 001077234.1_23523001_1 - 0.48 10.4 5.4 0.84 9.6 5.4 1.3 1 0 0 1 1 1 0 Basic region leucine zipper PAP_central PF04928.15 001198601.2_23527001_2 - 9.7e-117 388.2 0.0 1.8e-116 387.3 0.0 1.5 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.13 001198601.2_23527001_2 - 8.1e-26 90.5 2.2 1e-18 67.5 0.0 2.6 1 1 1 2 2 2 2 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.21 001198601.2_23527001_2 - 9.5e-14 51.3 0.0 2.1e-13 50.3 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Spt5_N PF11942.6 001198601.2_23527001_3 - 0.57 11.1 4.2 0.86 10.5 4.2 1.2 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Phosphorylase PF00343.18 001031034.1_23528001_2 - 0 1150.2 0.0 0 1150.0 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase SynMuv_product PF06047.9 001006437.1_23524001_3 - 1.7e-49 166.0 2.0 1.7e-49 166.0 2.0 2.9 2 1 0 2 2 2 1 Ras-induced vulval development antagonist NKAP PF15692.3 001006437.1_23524001_3 - 2.7e-14 53.5 19.1 2.7e-14 53.5 19.1 4.7 4 1 1 5 5 5 1 NF-kappa-B-activating protein Macoilin PF09726.7 001006437.1_23524001_3 - 0.02 13.3 17.6 0.034 12.6 17.6 1.4 1 0 0 1 1 1 0 Transmembrane protein Ndc1_Nup PF09531.8 001006437.1_23524001_3 - 1.2 7.6 11.2 1.6 7.2 11.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FAM60A PF15396.4 001006437.1_23524001_3 - 5.1 6.9 29.9 0.78 9.6 25.2 2.1 2 0 0 2 2 2 0 Protein Family FAM60A GREB1 PF15782.3 001006437.1_23524001_3 - 7.4 3.4 17.5 9.6 3.0 17.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Peptidase_S64 PF08192.9 001006437.1_23524001_3 - 8.5 4.6 17.9 12 4.1 17.9 1.3 1 0 0 1 1 1 0 Peptidase family S64 Peptidase_M16 PF00675.18 001199472.1_23524001_1 - 3e-56 189.4 0.2 4.4e-56 188.9 0.2 1.2 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.19 001199472.1_23524001_1 - 5.5e-38 130.7 0.0 2.4e-37 128.6 0.0 1.9 2 0 0 2 2 2 1 Peptidase M16 inactive domain Pkinase PF00069.23 204150.1_23523001_1 - 9.9e-69 231.5 0.0 1.2e-68 231.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 204150.1_23523001_1 - 3.1e-35 121.6 0.0 4.7e-35 121.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 204150.1_23523001_1 - 0.00099 19.0 0.0 0.0017 18.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.4 204150.1_23523001_1 - 0.063 12.8 0.1 0.097 12.1 0.1 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.18 204150.1_23523001_1 - 0.064 12.7 0.2 0.097 12.1 0.2 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kinase-like PF14531.4 204150.1_23523001_1 - 0.074 12.2 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.12 204150.1_23523001_1 - 0.1 11.8 0.3 0.15 11.2 0.3 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RisS_PPD PF16524.3 204150.1_23523001_3 - 0.17 12.0 0.0 0.27 11.4 0.0 1.2 1 0 0 1 1 1 0 Periplasmic domain of Sensor histidine kinase RisS Pkinase PF00069.23 001030940.1_23525001_3 - 9.3e-67 225.0 0.0 1.2e-66 224.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001030940.1_23525001_3 - 1.4e-33 116.1 0.0 2.3e-33 115.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PX PF00787.22 001030940.1_23525001_3 - 1.5e-23 82.8 0.2 3.2e-23 81.7 0.2 1.6 1 0 0 1 1 1 1 PX domain Pkinase_C PF00433.22 001030940.1_23525001_3 - 5.7e-05 23.6 1.3 0.0019 18.7 0.1 2.5 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.4 001030940.1_23525001_3 - 0.00016 21.0 0.0 0.00045 19.5 0.0 1.6 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.4 001030940.1_23525001_3 - 0.0084 15.6 0.1 0.68 9.4 0.1 2.2 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 001030940.1_23525001_3 - 0.019 14.2 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CAP-ZIP_m PF15255.4 001012593.2_23529001_2 - 2.1e-60 202.9 3.9 2.1e-60 202.9 3.9 2.6 2 0 0 2 2 2 1 WASH complex subunit CAP-Z interacting, central region DSPc PF00782.18 001031069.1_23525001_1 - 4.2e-13 49.1 0.0 8.6e-13 48.1 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CBM_20 PF00686.17 001031069.1_23525001_1 - 3.5e-07 29.9 0.0 6.1e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Starch binding domain TFIIA PF03153.11 001204866.1_23524001_3 - 1e-111 374.8 9.1 1.3e-111 374.4 9.1 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF469 PF04320.12 001204866.1_23524001_3 - 0.11 13.3 0.6 0.27 12.0 0.6 1.7 1 0 0 1 1 1 0 Protein with unknown function (DUF469) TRAPP PF04051.14 001252160.1_23523001_1 - 5.5e-44 149.3 0.1 8.9e-44 148.6 0.1 1.3 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component RhoGEF PF00621.18 001252063.1_23529001_1 - 3.9e-38 131.4 6.0 3.9e-38 131.4 6.0 3.7 2 1 0 2 2 2 1 RhoGEF domain PH PF00169.27 001252063.1_23529001_1 - 4.8e-09 36.5 0.2 1.4e-08 35.0 0.2 1.9 1 0 0 1 1 1 1 PH domain CRAL_TRIO_2 PF13716.4 001252063.1_23529001_1 - 1.1e-06 28.6 0.0 2.4e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain SH3_1 PF00018.26 001252063.1_23529001_1 - 3.1e-05 23.4 0.1 9.7e-05 21.8 0.1 1.9 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001252063.1_23529001_1 - 4.4e-05 23.1 0.9 0.00014 21.5 0.1 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.15 001252063.1_23529001_1 - 0.0001 21.8 0.4 0.00027 20.4 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain Spectrin PF00435.19 001252063.1_23529001_1 - 0.00018 21.8 17.7 0.0012 19.1 0.0 4.5 3 1 1 4 4 4 2 Spectrin repeat PH_10 PF15411.4 001252063.1_23529001_1 - 0.0089 16.2 0.7 0.023 14.8 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain RhoGAP PF00620.25 001006479.2_23528001_3 - 7.4e-33 113.4 0.4 5.3e-32 110.6 0.1 2.3 2 0 0 2 2 2 1 RhoGAP domain Nramp PF01566.16 001128101.1_23524001_3 - 1.1e-118 396.1 12.8 1.8e-118 395.5 12.8 1.3 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein NAPRTase PF04095.14 001030728.1_23524001_3 - 2.6e-72 243.2 0.0 4.3e-72 242.5 0.0 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family ACBP PF00887.17 001277547.1_23523001_3 - 8.5e-24 83.5 0.3 1.4e-23 82.8 0.3 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein Ank_2 PF12796.5 001277547.1_23523001_3 - 6.1e-16 58.6 0.0 1.2e-15 57.7 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 001277547.1_23523001_3 - 5.6e-15 54.9 0.0 1.6e-06 28.1 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 001277547.1_23523001_3 - 5.6e-15 55.1 0.1 1.5e-10 41.0 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 001277547.1_23523001_3 - 1.3e-14 54.2 0.2 3.7e-13 49.6 0.1 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 001277547.1_23523001_3 - 4.1e-12 45.0 0.1 0.00017 21.6 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ras PF00071.20 001277606.1_23528001_2 - 1.2e-30 106.1 0.0 1.9e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001277606.1_23528001_2 - 5.6e-09 36.1 0.0 1e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001277606.1_23528001_2 - 0.011 15.0 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family FeoB_N PF02421.16 001277606.1_23528001_2 - 0.052 12.9 0.1 0.18 11.2 0.1 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B DUF258 PF03193.14 001277606.1_23528001_2 - 0.056 13.2 0.3 6.3 6.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 EF-hand_7 PF13499.4 001277649.1_23522001_2 - 1.1e-11 44.9 5.5 3.6e-10 40.1 0.9 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001277649.1_23522001_2 - 1.9e-10 39.7 4.9 0.00014 21.4 0.6 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.30 001277649.1_23522001_2 - 4e-10 38.4 8.1 0.00014 21.0 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 001277649.1_23522001_2 - 3.9e-06 26.4 6.3 0.011 15.3 2.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 001277649.1_23522001_2 - 0.0002 20.6 4.7 0.058 12.8 0.1 2.5 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.7 001277649.1_23522001_2 - 0.0011 19.1 0.2 0.0069 16.6 0.2 2.0 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region NuiA PF07924.9 001277649.1_23522001_2 - 0.09 13.0 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 Nuclease A inhibitor-like protein EF-hand_4 PF12763.5 001277649.1_23522001_2 - 0.27 11.1 4.6 0.76 9.6 0.1 2.6 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand Gal4_dimer PF03902.11 001277649.1_23522001_2 - 0.27 11.3 2.1 1 9.4 0.3 2.2 1 1 1 2 2 2 0 Gal4-like dimerisation domain HIG_1_N PF04588.11 001030957.1_23523001_3 - 3.2e-17 62.4 0.5 5.8e-17 61.6 0.5 1.5 1 0 0 1 1 1 1 Hypoxia induced protein conserved region MPC PF03650.11 001031524.1_23525001_1 - 1.9e-31 108.3 0.0 3.1e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) WCOR413 PF05562.9 001001312.2_23524001_2 - 0.11 12.2 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Cold acclimation protein WCOR413 Filament PF00038.19 001001312.2_23524001_3 - 1.3e-112 376.2 36.1 1.6e-112 376.0 36.1 1.0 1 0 0 1 1 1 1 Intermediate filament protein DUF4407 PF14362.4 001001312.2_23524001_3 - 0.0027 17.0 18.9 0.0096 15.2 10.1 2.9 1 1 2 3 3 3 2 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.10 001001312.2_23524001_3 - 0.0055 16.6 2.5 0.0055 16.6 2.5 3.7 3 1 0 4 4 4 2 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.8 001001312.2_23524001_3 - 0.11 12.6 24.0 2 8.5 1.6 4.1 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family SPATA1_C PF15743.3 001001312.2_23524001_3 - 0.11 12.4 0.2 0.11 12.4 0.2 3.9 3 1 0 3 3 3 0 Spermatogenesis-associated C-terminus Reo_sigmaC PF04582.10 001001312.2_23524001_3 - 0.13 11.5 7.6 0.51 9.5 2.7 2.7 1 1 1 2 2 2 0 Reovirus sigma C capsid protein WXG100 PF06013.10 001001312.2_23524001_3 - 0.39 10.8 9.0 0.2 11.7 0.8 3.6 3 2 0 3 3 3 0 Proteins of 100 residues with WXG RasGAP_C PF03836.13 001001312.2_23524001_3 - 0.65 10.0 21.0 0.37 10.8 0.2 3.6 3 1 1 4 4 3 0 RasGAP C-terminus Keratin_2_head PF16208.3 001001312.2_23524001_3 - 1.1 9.3 44.0 1.8 8.6 44.0 1.3 1 0 0 1 1 1 0 Keratin type II head PI3K_P85_iSH2 PF16454.3 001001312.2_23524001_3 - 1.5 8.2 25.0 0.7 9.3 3.5 3.6 3 1 0 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Baculo_PEP_C PF04513.10 001001312.2_23524001_3 - 1.7 8.6 17.7 0.49 10.3 1.5 3.8 2 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Golgin_A5 PF09787.7 001001312.2_23524001_3 - 1.7 7.9 28.0 8.6 5.6 17.7 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF2115 PF09888.7 001001312.2_23524001_3 - 2.8 8.3 11.9 0.18 12.2 1.5 3.1 1 1 2 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2115) Spc7 PF08317.9 001001312.2_23524001_3 - 2.9 6.6 28.7 0.05 12.3 12.1 2.6 2 1 1 3 3 3 0 Spc7 kinetochore protein ADIP PF11559.6 001001312.2_23524001_3 - 3.1 7.7 26.9 3.7 7.5 2.4 4.1 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding Tcp11 PF05794.11 001001897.1_23525001_3 - 1.1e-108 363.9 0.9 1.1e-108 363.9 0.9 1.4 2 0 0 2 2 2 1 T-complex protein 11 FTHFS PF01268.17 001039303.1_23528001_2 - 6.8e-262 869.5 0.0 8.9e-262 869.1 0.0 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.17 001039303.1_23528001_2 - 9.9e-67 223.1 1.4 9.9e-67 223.1 1.4 1.6 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.21 001039303.1_23528001_2 - 1.5e-35 121.8 0.1 3.5e-35 120.7 0.1 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain zf-C3HC4 PF00097.23 001039303.1_23528001_3 - 0.85 9.4 6.9 4.5 7.1 6.9 2.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) adh_short PF00106.23 001030795.2_23522001_1 - 1.3e-31 109.5 0.0 1.4e-24 86.5 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.4 001030795.2_23522001_1 - 3.5e-23 82.2 0.0 4.9e-16 58.9 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001030795.2_23522001_1 - 4.3e-06 26.6 0.0 6.4e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.10 001030795.2_23522001_1 - 0.0016 17.5 0.0 0.0024 17.0 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein HATPase_c PF02518.24 001030795.2_23522001_1 - 0.0068 16.8 0.0 0.13 12.7 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MRG PF05712.11 001037176.1_23524001_3 - 1.1e-54 184.6 0.6 1.9e-54 183.9 0.6 1.3 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.6 001037176.1_23524001_3 - 8.6e-16 57.5 0.4 1.8e-15 56.4 0.4 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Fmp27_WPPW PF10359.7 001037176.1_23524001_3 - 0.047 12.4 0.7 0.063 12.0 0.7 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain UCR_hinge PF02320.14 001277673.1_23522001_2 - 7.8e-24 83.5 8.8 1.5e-23 82.6 8.8 1.5 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein MBT PF02820.16 001006238.1_23526001_2 - 2.1e-97 319.4 6.0 1.5e-27 95.6 0.3 4.4 4 0 0 4 4 4 4 mbt repeat Ribosomal_60s PF00428.17 001006238.1_23526001_2 - 1.1 9.7 5.9 3.2 8.2 5.9 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Astro_capsid_p PF12226.6 001006238.1_23526001_2 - 1.5 7.7 5.3 2.5 7.0 5.3 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein EF-hand_7 PF13499.4 102414.1_23523120_1 - 5.9e-11 42.6 4.2 5.5e-10 39.5 0.9 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.4 102414.1_23523120_1 - 7.7e-10 37.8 5.2 0.00019 21.0 0.6 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.30 102414.1_23523120_1 - 1.4e-09 36.7 8.1 0.0002 20.5 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 102414.1_23523120_1 - 8e-06 25.4 6.3 0.016 14.8 2.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 102414.1_23523120_1 - 0.00043 19.6 4.7 0.08 12.4 0.1 2.4 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.7 102414.1_23523120_1 - 0.0022 18.2 0.2 0.012 15.8 0.2 1.9 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Gal4_dimer PF03902.11 102414.1_23523120_1 - 0.45 10.6 1.9 1.4 9.0 0.3 2.1 1 1 1 2 2 2 0 Gal4-like dimerisation domain EF-hand_4 PF12763.5 102414.1_23523120_1 - 1.1 9.1 4.8 1.1 9.1 0.1 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.4 102415.1_23522120_3 - 2.1e-06 27.9 0.7 3.2e-06 27.4 0.7 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 102415.1_23522120_3 - 2.9e-05 23.2 0.7 0.00016 20.8 0.0 2.1 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 102415.1_23522120_3 - 0.00046 19.8 0.5 0.076 12.9 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.4 102415.1_23522120_3 - 0.052 13.2 0.5 0.096 12.3 0.3 1.5 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.4 102415.1_23522120_3 - 0.067 12.6 0.1 0.067 12.6 0.1 2.0 2 0 0 2 2 2 0 EF hand SPARC_Ca_bdg PF10591.7 102415.1_23522120_3 - 0.12 12.6 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Gal4_dimer PF03902.11 102415.1_23522120_3 - 0.46 10.5 1.3 1.2 9.3 0.3 1.9 1 1 1 2 2 2 0 Gal4-like dimerisation domain EF-hand_7 PF13499.4 102413.1_23523120_3 - 6.6e-11 42.4 4.2 6e-10 39.3 0.9 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.4 102413.1_23523120_3 - 6.8e-10 38.0 4.8 0.00021 20.9 0.6 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.30 102413.1_23523120_3 - 1.7e-09 36.4 8.0 0.00021 20.5 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 102413.1_23523120_3 - 9.2e-06 25.2 6.3 0.017 14.7 2.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 102413.1_23523120_3 - 0.00048 19.4 4.7 0.086 12.3 0.1 2.4 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.7 102413.1_23523120_3 - 0.0023 18.1 0.2 0.014 15.6 0.2 1.9 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Gal4_dimer PF03902.11 102413.1_23523120_3 - 0.49 10.5 1.9 1.4 9.0 0.3 2.2 1 1 1 2 2 2 0 Gal4-like dimerisation domain EF-hand_4 PF12763.5 102413.1_23523120_3 - 0.76 9.6 4.4 1.2 9.0 0.1 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand DUF4693 PF15764.3 036657.2_23523120_2 - 6.5e-103 344.1 6.9 1.1e-102 343.3 6.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4693) BRAP2 PF07576.10 001079761.1_23526001_1 - 6.6e-36 122.4 0.8 1.2e-35 121.5 0.8 1.4 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.17 001079761.1_23526001_1 - 1.6e-20 73.0 7.1 1.6e-20 73.0 7.1 2.2 2 0 0 2 2 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.4 001079761.1_23526001_1 - 2.4e-08 33.9 7.0 2.4e-08 33.9 7.0 3.0 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001079761.1_23526001_1 - 1.5e-07 31.0 6.1 1.5e-07 31.0 6.1 2.5 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001079761.1_23526001_1 - 1.3e-05 25.2 4.7 1.3e-05 25.2 4.7 2.4 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.3 001079761.1_23526001_1 - 1.6e-05 24.4 1.8 1.6e-05 24.4 1.8 2.6 3 0 0 3 3 2 1 RING-like zinc finger zf-RING_UBOX PF13445.4 001079761.1_23526001_1 - 3.6e-05 23.5 0.4 3.6e-05 23.5 0.4 3.4 2 1 1 3 3 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 001079761.1_23526001_1 - 3.9e-05 23.4 5.6 3.9e-05 23.4 5.6 3.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.23 001079761.1_23526001_1 - 0.00012 21.8 6.2 0.00012 21.8 6.2 2.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.20 001079761.1_23526001_1 - 0.0018 17.9 0.0 0.0034 17.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KASH_CCD PF14662.4 001079761.1_23526001_1 - 0.0044 16.8 23.9 0.0078 16.0 23.9 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH zf-ANAPC11 PF12861.5 001079761.1_23526001_1 - 0.0089 15.9 3.1 0.032 14.2 3.1 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.4 001079761.1_23526001_1 - 0.012 15.4 18.4 0.051 13.3 7.7 2.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF3464 PF11947.6 001079761.1_23526001_1 - 0.16 11.6 0.2 0.38 10.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) DUF2935 PF11155.6 001079761.1_23526001_1 - 0.25 11.5 3.2 0.58 10.4 3.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) Baculo_PEP_C PF04513.10 001079761.1_23526001_1 - 0.31 10.9 7.6 0.25 11.3 5.3 1.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus V_ATPase_I PF01496.17 001079761.1_23526001_1 - 0.31 8.7 16.2 0.55 7.9 10.6 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Atg14 PF10186.7 001079761.1_23526001_1 - 0.4 9.6 16.0 0.72 8.7 16.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Vac_Fusion PF02346.14 001079761.1_23526001_1 - 0.49 9.9 2.9 1.4 8.5 0.7 2.5 1 1 1 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 Peptidase_S46 PF10459.7 001079761.1_23526001_1 - 0.62 8.5 7.1 0.98 7.9 7.1 1.2 1 0 0 1 1 1 0 Peptidase S46 DUF342 PF03961.11 001079761.1_23526001_1 - 0.64 8.4 14.6 0.95 7.9 14.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) GBP_C PF02841.12 001079761.1_23526001_1 - 0.69 9.1 22.2 0.31 10.3 17.1 2.1 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain Zn_ribbon_17 PF17120.3 001079761.1_23526001_1 - 1.1 8.8 16.9 0.39 10.2 5.8 3.1 3 0 0 3 3 2 0 Zinc-ribbon, C4HC2 type NPV_P10 PF05531.10 001079761.1_23526001_1 - 1.7 9.0 6.6 6.9 7.1 5.0 2.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Prok-RING_4 PF14447.4 001079761.1_23526001_1 - 1.8 8.4 18.1 0.39 10.5 7.4 2.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 KELK PF15796.3 001079761.1_23526001_1 - 2.5 8.5 18.3 1.6 9.1 6.8 2.9 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Spc7 PF08317.9 001079761.1_23526001_1 - 2.9 6.5 24.9 7.2 5.3 24.9 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.13 001079761.1_23526001_1 - 5.6 6.3 10.3 9.6 5.5 10.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit FlaC_arch PF05377.9 001079761.1_23526001_1 - 5.8 7.3 7.4 1.2 9.5 1.4 2.9 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) TMPIT PF07851.11 001079761.1_23526001_1 - 7.2 5.6 12.1 13 4.8 12.1 1.3 1 0 0 1 1 1 0 TMPIT-like protein APG6 PF04111.10 001079761.1_23526001_1 - 7.8 5.6 21.4 17 4.5 21.4 1.5 1 0 0 1 1 1 0 Autophagy protein Apg6 Ham1p_like PF01725.14 073522.2_23522120_2 - 2.7e-43 147.7 0.0 3.4e-43 147.4 0.0 1.1 1 0 0 1 1 1 1 Ham1 family Tropomodulin PF03250.12 204774.1_23523001_3 - 1.3e-60 203.4 6.1 2.3e-60 202.6 6.1 1.4 1 0 0 1 1 1 1 Tropomodulin LRR_6 PF13516.4 204774.1_23523001_3 - 0.62 10.1 0.0 0.62 10.1 0.0 3.2 4 0 0 4 4 4 0 Leucine Rich repeat zf-B_box PF00643.22 001319001.1_23526001_1 - 3.3e-11 43.0 26.4 1.3e-07 31.5 8.9 5.1 5 1 0 5 5 5 2 B-box zinc finger zf-RING_5 PF14634.4 001319001.1_23526001_1 - 1.4e-07 31.2 3.7 1.4e-07 31.2 3.7 4.5 4 1 0 4 4 4 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 001319001.1_23526001_1 - 0.00028 20.7 1.3 0.00028 20.7 1.3 3.6 4 0 0 4 4 4 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001319001.1_23526001_1 - 0.002 17.8 1.4 0.002 17.8 1.4 4.7 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001319001.1_23526001_1 - 0.004 17.3 4.9 0.004 17.3 4.9 4.5 4 0 0 4 4 4 1 Ring finger domain PHD PF00628.27 001319001.1_23526001_1 - 0.0055 16.5 18.5 0.0055 16.5 18.5 4.7 4 1 0 4 4 4 1 PHD-finger Bromodomain PF00439.23 001319001.1_23526001_1 - 0.092 12.7 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Bromodomain RbpA PF13397.4 001319001.1_23526001_1 - 0.65 10.5 3.5 9.6 6.8 0.4 2.6 2 0 0 2 2 2 0 RNA polymerase-binding protein Urotensin_II PF02083.13 206990.2_23522001_1 - 2.4e-06 26.7 1.0 4.2e-06 26.0 1.0 1.4 1 0 0 1 1 1 1 Urotensin II Pkinase PF00069.23 001126479.1_16123001_2 - 2.6e-43 148.1 0.0 3.8e-43 147.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001126479.1_16123001_2 - 4.4e-17 62.1 0.0 6.3e-17 61.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001126479.1_16123001_2 - 1.1e-06 28.1 0.0 1.7e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001126479.1_16123001_2 - 0.00039 19.7 0.0 0.00061 19.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001126479.1_16123001_2 - 0.00056 19.8 0.5 0.003 17.4 0.4 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family DUF4584 PF15223.4 001347635.1_23525001_1 - 5.3e-26 91.9 4.2 5.3e-26 91.9 4.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4584) Ski_Sno PF02437.15 001347635.1_23525001_1 - 5.5e-15 55.0 0.3 9.2e-15 54.2 0.3 1.3 1 0 0 1 1 1 1 SKI/SNO/DAC family SPT_ssu-like PF11779.6 001302113.1_23524001_1 - 5.6e-13 48.2 7.1 9.4e-13 47.4 7.1 1.4 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like BpuSI_N PF15516.4 001302113.1_23524001_1 - 0.093 12.7 0.1 0.14 12.1 0.1 1.2 1 0 0 1 1 1 0 BpuSI N-terminal domain Somatostatin PF03002.13 204455.1_23521001_1 - 6.6e-12 45.0 7.8 9.9e-12 44.5 7.8 1.3 1 0 0 1 1 1 1 Somatostatin/Cortistatin family SPT_ssu-like PF11779.6 001302112.1_23524001_3 - 6.1e-13 48.0 7.1 1e-12 47.3 7.1 1.4 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like BpuSI_N PF15516.4 001302112.1_23524001_3 - 0.1 12.6 0.1 0.15 12.0 0.1 1.2 1 0 0 1 1 1 0 BpuSI N-terminal domain SH2 PF00017.22 001318450.1_23522001_2 - 8.2e-06 25.7 0.0 1.4e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 SH2 domain Hormone_recep PF00104.28 001279699.1_37523001_1 - 7e-20 71.4 0.0 1.5e-19 70.3 0.0 1.5 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001311334.1_37523001_1 - 7.1e-31 106.4 15.5 1.3e-30 105.5 15.5 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001311334.1_37523001_1 - 3.7e-18 65.7 0.0 7.3e-18 64.8 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Rad51 PF08423.9 001279453.1_37524001_3 - 5.8e-110 366.4 0.0 7.5e-110 366.0 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.19 001279453.1_37524001_3 - 2.3e-11 43.5 0.1 3.3e-11 43.0 0.1 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.4 001279453.1_37524001_3 - 3.5e-06 27.4 0.8 8.6e-06 26.2 0.8 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain AAA_25 PF13481.4 001279453.1_37524001_3 - 7.7e-06 25.5 0.0 1.1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain ATPase PF06745.11 001279453.1_37524001_3 - 8.5e-06 25.2 0.1 1.5e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 KaiC DUF128 PF01995.14 001279453.1_37524001_3 - 0.0024 17.1 0.1 0.0041 16.3 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF128 HSP70 PF00012.18 001279671.1_37525001_2 - 3.1e-263 874.3 8.3 3.5e-263 874.1 8.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 001279671.1_37525001_2 - 2e-17 62.9 0.2 4e-16 58.6 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.4 001279671.1_37525001_2 - 0.0005 20.3 0.9 4.7 7.6 0.0 3.5 3 1 0 3 3 3 2 Cell division protein FtsA BcrAD_BadFG PF01869.18 001279671.1_37525001_2 - 0.01 15.2 0.1 1.6 8.1 0.0 2.3 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DDR PF08841.8 001279671.1_37525001_2 - 0.035 12.9 0.2 0.21 10.4 0.1 2.0 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain FGGY_C PF02782.14 001279671.1_37525001_2 - 0.066 12.8 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Radial_spoke_3 PF06098.9 001279671.1_37525001_2 - 0.39 9.8 6.8 0.82 8.8 6.8 1.5 1 0 0 1 1 1 0 Radial spoke protein 3 p450 PF00067.20 001279765.1_37528001_3 - 3.8e-137 457.7 0.0 4.7e-137 457.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FOXP-CC PF16159.3 001311335.1_37525001_1 - 2e-35 121.1 4.2 2e-35 121.1 4.2 3.6 2 1 1 3 3 3 1 FOXP coiled-coil domain Forkhead PF00250.16 001311335.1_37525001_1 - 1.5e-27 95.6 0.1 4.1e-27 94.2 0.1 1.7 1 0 0 1 1 1 1 Forkhead domain Bestrophin PF01062.19 001311335.1_37525001_1 - 0.18 11.0 0.0 0.18 11.0 0.0 2.5 3 0 0 3 3 3 0 Bestrophin, RFP-TM, chloride channel IRK PF01007.18 001279632.1_37523001_1 - 9.3e-86 287.6 0.0 1.1e-85 287.4 0.0 1.0 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 001279632.1_37523001_1 - 0.00017 21.4 3.8 0.00038 20.2 3.8 1.7 1 1 0 1 1 1 1 Ion channel DUF846 PF05832.10 001281851.1_37523001_1 - 1.5e-54 183.6 7.0 2.3e-54 183.1 7.0 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) zf-C4 PF00105.16 001282896.1_37524001_3 - 4e-24 84.7 14.3 4e-24 84.7 14.3 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001282896.1_37524001_3 - 7.9e-11 41.8 0.4 7.9e-11 41.8 0.4 2.3 2 1 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor Hormone_recep PF00104.28 001279472.1_37523001_1 - 2.9e-15 56.3 0.0 6.6e-15 55.1 0.0 1.5 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor PPARgamma_N PF12577.6 001290200.1_37524001_3 - 7.8e-33 112.8 0.7 2e-32 111.5 0.7 1.8 1 0 0 1 1 1 1 PPAR gamma N-terminal region zf-C4 PF00105.16 001290200.1_37524001_3 - 2.8e-27 94.8 15.4 4.6e-27 94.1 15.4 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001290200.1_37524001_3 - 1.1e-16 60.9 2.7 2.7e-16 59.6 2.7 1.6 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor LRR_8 PF13855.4 001279607.1_37525001_3 - 7e-38 128.1 15.4 1.1e-12 47.4 5.7 3.6 3 0 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 001279607.1_37525001_3 - 1.4e-14 53.8 24.4 0.00041 20.5 1.1 5.8 5 1 3 8 8 8 6 Leucine Rich repeats (2 copies) LRRNT PF01462.16 001279607.1_37525001_3 - 2.6e-10 39.6 3.1 2.6e-10 39.6 3.1 3.1 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.4 001279607.1_37525001_3 - 5.1e-10 39.3 0.1 9.4e-06 25.5 0.4 3.1 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001279607.1_37525001_3 - 2.4e-05 23.8 9.1 0.016 14.6 3.3 2.8 2 1 1 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.4 001279607.1_37525001_3 - 0.072 13.1 12.1 17 5.6 0.1 6.7 7 0 0 7 7 7 0 Leucine Rich repeat LRR_1 PF00560.31 001279607.1_37525001_3 - 0.28 11.6 10.4 1.3e+02 3.5 0.1 6.8 7 1 0 7 7 7 0 Leucine Rich Repeat C1-set PF07654.13 001282888.1_37522001_1 - 1.5e-24 86.2 0.1 2.7e-24 85.3 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_II_alpha PF00993.18 001282888.1_37522001_1 - 6.6e-20 70.5 0.0 9.5e-20 70.0 0.0 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001282888.1_37522001_1 - 1.8e-06 27.1 0.2 3.3e-06 26.3 0.2 1.5 1 0 0 1 1 1 1 C1-set C-terminal domain C2-set_2 PF08205.10 001282888.1_37522001_1 - 2.4e-06 27.4 0.1 4.2e-06 26.6 0.1 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 001282888.1_37522001_1 - 5.1e-06 26.9 0.1 8.1e-06 26.2 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001282888.1_37522001_1 - 4.8e-05 23.2 0.0 7.6e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 001282888.1_37522001_1 - 0.00014 22.0 0.1 0.00022 21.4 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001282888.1_37522001_1 - 0.00056 19.9 0.1 0.00094 19.2 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001282888.1_37522001_1 - 0.0078 15.9 0.1 0.012 15.3 0.1 1.3 1 0 0 1 1 1 1 Marek's disease glycoprotein A p450 PF00067.20 001279590.1_37524001_1 - 9.3e-86 288.3 0.1 1.1e-85 288.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF349 PF03993.10 001279590.1_37524001_1 - 3 8.1 6.1 0.96 9.7 2.4 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) ecTbetaR2 PF08917.8 001311323.1_37524001_1 - 1e-40 137.9 10.5 2.8e-40 136.5 10.5 1.8 1 0 0 1 1 1 1 Transforming growth factor beta receptor 2 ectodomain Pkinase_Tyr PF07714.15 001311323.1_37524001_1 - 4.5e-31 108.0 0.0 1e-30 106.8 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001311323.1_37524001_1 - 1.3e-30 106.5 0.0 2e-30 105.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Cpn60_TCP1 PF00118.22 001282890.1_37524001_2 - 8.6e-162 539.0 4.2 9.8e-162 538.9 4.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FGF PF00167.16 001279689.1_37524001_2 - 1e-45 154.7 0.1 1.5e-45 154.2 0.1 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Ald_Xan_dh_C2 PF02738.16 001282892.1_37529001_1 - 2.1e-185 617.2 0.0 3e-185 616.7 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001282892.1_37529001_1 - 1.4e-47 161.5 0.0 3.3e-47 160.3 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 001282892.1_37529001_1 - 4.8e-32 110.5 0.1 9.1e-32 109.6 0.1 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 001282892.1_37529001_1 - 4.2e-31 106.6 0.6 9.1e-31 105.5 0.6 1.6 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 001282892.1_37529001_1 - 3e-27 94.6 0.0 8.7e-27 93.2 0.0 1.8 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001282892.1_37529001_1 - 3.6e-09 36.3 0.1 3.6e-09 36.3 0.1 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DUF218 PF02698.15 001282892.1_37529001_1 - 0.028 14.3 0.0 0.093 12.6 0.0 1.8 2 0 0 2 2 2 0 DUF218 domain 7tm_1 PF00001.19 001279588.1_37525001_3 - 1.1e-28 100.2 21.0 2.3e-28 99.1 21.0 1.6 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.4 001279588.1_37525001_3 - 4.8e-27 93.4 6.6 3e-09 36.4 0.3 5.0 3 2 2 5 5 5 4 Leucine rich repeat LRR_5 PF13306.4 001279588.1_37525001_3 - 8.6e-17 61.2 0.3 5e-10 39.3 0.7 2.5 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001279588.1_37525001_3 - 4.1e-06 26.9 6.4 9.4 6.7 0.1 6.1 4 1 1 6 6 6 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001279588.1_37525001_3 - 0.088 12.2 0.4 0.53 9.6 0.2 2.3 1 1 1 2 2 2 0 Leucine-rich repeat LRR_8 PF13855.4 001311317.1_37527001_2 - 2.4e-74 244.9 127.7 2.6e-14 52.6 6.5 12.2 4 3 9 14 14 14 14 Leucine rich repeat LRR_5 PF13306.4 001311317.1_37527001_2 - 1.6e-26 92.6 18.1 6.2e-10 39.0 0.9 6.9 3 2 4 7 7 7 4 Leucine rich repeats (6 copies) TIR PF01582.18 001311317.1_37527001_2 - 6.9e-26 91.0 0.3 1.2e-25 90.2 0.3 1.3 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.5 001311317.1_37527001_2 - 3.8e-23 81.0 99.2 0.00024 21.2 2.8 13.4 5 3 9 16 16 16 13 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001311317.1_37527001_2 - 2.1e-15 56.5 36.9 1.2e-05 24.8 4.5 6.3 3 2 4 7 7 7 6 Leucine-rich repeat TIR_2 PF13676.4 001311317.1_37527001_2 - 8.7e-12 45.1 0.0 1.7e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 TIR domain DUF1863 PF08937.9 001311317.1_37527001_2 - 0.01 16.0 0.0 0.043 14.0 0.0 2.0 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) Hormone_1 PF00103.18 001279528.1_37522001_1 - 3.1e-39 134.8 2.0 4e-39 134.5 2.0 1.1 1 0 0 1 1 1 1 Somatotropin hormone family TGFb_propeptide PF00688.16 001311314.1_37523001_1 - 1.6e-32 113.1 0.0 2.1e-32 112.7 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001311314.1_37523001_1 - 4.7e-22 78.7 0.9 4.7e-22 78.7 0.9 2.1 3 0 0 3 3 3 1 Transforming growth factor beta like domain MH2 PF03166.12 204561.1_23524001_3 - 1.3e-79 266.6 0.1 2e-79 266.0 0.1 1.3 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 204561.1_23524001_3 - 2.5e-43 146.4 2.0 4.4e-43 145.5 2.0 1.4 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.7 204561.1_23524001_3 - 0.0047 16.6 0.0 0.0083 15.8 0.0 1.4 1 0 0 1 1 1 1 Interferon-regulatory factor 3 Peptidase_M20 PF01546.26 001279465.1_37524001_3 - 1.2e-34 119.7 0.0 1.6e-34 119.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.12 001279465.1_37524001_3 - 1e-14 54.2 0.0 1.9e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.15 001279465.1_37524001_3 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 Big_4 PF07532.9 001279465.1_37524001_3 - 0.12 12.0 0.1 1.3 8.6 0.0 2.4 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 4) ANTH PF07651.14 001079762.2_23527001_2 - 8.6e-77 257.7 1.1 1.3e-76 257.1 1.1 1.3 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.18 001079762.2_23527001_2 - 8.5e-14 51.5 0.2 1.6e-13 50.7 0.2 1.4 1 0 0 1 1 1 1 ENTH domain SDP_N PF12278.6 001079762.2_23527001_2 - 0.027 14.0 0.4 0.049 13.2 0.4 1.3 1 0 0 1 1 1 0 Sex determination protein N terminal DUF4355 PF14265.4 001079762.2_23527001_2 - 0.23 11.6 2.2 0.45 10.6 2.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) Sugar_tr PF00083.22 001347709.1_23527001_2 - 3.9e-95 319.2 19.1 5.9e-95 318.6 19.1 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001347709.1_23527001_2 - 1.9e-19 69.7 22.5 1.9e-19 69.7 22.5 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily p450 PF00067.20 001329480.1_23525001_2 - 1.2e-129 432.9 1.1 1.5e-129 432.7 1.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 TSP_C PF05735.10 001279735.1_37529001_2 - 2e-96 321.5 1.7 2.8e-96 321.0 1.7 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.16 001279735.1_37529001_2 - 2.1e-59 196.8 142.0 8.6e-12 44.4 13.4 9.8 7 2 2 9 9 9 9 Thrombospondin type 3 repeat TSP_1 PF00090.17 001279735.1_37529001_2 - 1e-42 144.0 46.2 2.2e-15 56.5 9.7 4.2 3 0 0 3 3 3 3 Thrombospondin type 1 domain VWC PF00093.16 001279735.1_37529001_2 - 1.2e-11 44.6 17.4 1.2e-11 44.6 17.4 5.9 5 2 1 6 6 6 1 von Willebrand factor type C domain EGF_3 PF12947.5 001279735.1_37529001_2 - 5.1e-06 26.4 8.6 5.1e-06 26.4 8.6 5.0 4 0 0 4 4 4 2 EGF domain EGF_CA PF07645.13 001279735.1_37529001_2 - 8.7e-06 25.7 1.7 8.7e-06 25.7 1.7 5.9 5 0 0 5 5 5 3 Calcium-binding EGF domain Laminin_G_3 PF13385.4 001279735.1_37529001_2 - 2.1e-05 24.6 1.7 0.00033 20.7 0.1 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily cEGF PF12662.5 001279735.1_37529001_2 - 0.00048 19.9 1.1 0.00048 19.9 1.1 4.9 4 0 0 4 4 4 2 Complement Clr-like EGF-like EGF PF00008.25 001279735.1_37529001_2 - 0.00076 19.6 7.9 0.00076 19.6 7.9 6.1 6 1 0 6 6 6 2 EGF-like domain Laminin_G_2 PF02210.22 001279735.1_37529001_2 - 0.0076 16.7 0.1 0.015 15.7 0.1 1.4 1 0 0 1 1 1 1 Laminin G domain GHBP PF12772.5 001279455.1_37524001_1 - 2.3e-31 109.3 6.0 2.8e-22 79.5 0.0 2.8 2 1 0 2 2 2 2 Growth hormone receptor binding EpoR_lig-bind PF09067.8 001279455.1_37524001_1 - 2.4e-07 30.8 0.2 6.3e-07 29.4 0.2 1.6 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 001279455.1_37524001_1 - 0.0046 17.1 0.4 0.013 15.7 0.0 1.9 2 0 0 2 2 2 1 Fibronectin type III domain IL6Ra-bind PF09240.8 001279455.1_37524001_1 - 0.042 14.1 0.3 0.13 12.5 0.2 1.8 2 0 0 2 2 2 0 Interleukin-6 receptor alpha chain, binding zf-C4 PF00105.16 001289636.1_37526001_1 - 4.3e-28 97.4 17.2 1e-27 96.2 17.2 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001289636.1_37526001_1 - 1.5e-14 53.9 0.2 6e-14 52.0 0.2 1.9 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor CDC45 PF02724.12 001289636.1_37526001_1 - 3.3 5.8 8.5 5.1 5.1 8.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Transferrin PF00405.15 001311321.1_37525001_1 - 3.1e-203 674.0 7.4 4.1e-110 367.9 0.5 2.0 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 001311321.1_37525001_1 - 8.6e-11 41.8 0.0 0.00015 21.4 0.0 3.2 3 1 0 3 3 3 2 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.18 001311321.1_37525001_1 - 0.023 14.0 0.0 7.3 5.8 0.0 3.3 3 0 0 3 3 3 0 Bacterial extracellular solute-binding proteins, family 3 Annexin PF00191.18 001279598.1_37523001_3 - 3.3e-97 318.4 10.1 9.9e-24 83.1 0.2 4.2 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.3 001279598.1_37523001_3 - 0.001 18.8 0.1 6.8 6.5 0.0 3.9 4 0 0 4 4 4 1 Myb DNA-binding like DUF2312 PF10073.7 001279598.1_37523001_3 - 0.026 14.0 0.1 0.87 9.1 0.0 3.0 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2312) DM PF00751.16 001279473.1_37525001_1 - 8.6e-20 70.2 15.8 2e-19 69.1 15.8 1.7 1 0 0 1 1 1 1 DM DNA binding domain ecTbetaR2 PF08917.8 001311319.1_37524001_1 - 8.6e-42 141.4 9.8 2.2e-41 140.1 9.8 1.7 1 0 0 1 1 1 1 Transforming growth factor beta receptor 2 ectodomain Pkinase_Tyr PF07714.15 001311319.1_37524001_1 - 1.6e-33 115.9 0.0 2.5e-33 115.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001311319.1_37524001_1 - 6.5e-32 110.8 0.0 9.8e-32 110.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Perilipin PF03036.14 001311340.1_37524001_2 - 2.6e-152 507.3 15.9 3.3e-152 507.0 15.9 1.0 1 0 0 1 1 1 1 Perilipin family HMA PF00403.24 001279651.1_37529001_3 - 1.1e-78 259.4 14.0 4.3e-13 49.4 0.2 7.5 7 0 0 7 7 7 6 Heavy-metal-associated domain E1-E2_ATPase PF00122.18 001279651.1_37529001_3 - 1.8e-60 203.9 1.6 4.1e-60 202.7 1.6 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.24 001279651.1_37529001_3 - 5.9e-58 196.5 0.2 1e-57 195.7 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 001279651.1_37529001_3 - 3.2e-05 23.7 1.4 0.00014 21.5 0.4 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3281 PF11685.6 001279651.1_37529001_3 - 0.061 12.5 0.0 0.16 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3281) RRM_3 PF08777.9 001279651.1_37529001_3 - 0.066 13.1 0.0 7.6 6.5 0.0 3.4 4 0 0 4 4 4 0 RNA binding motif Hydrolase_6 PF13344.4 001279651.1_37529001_3 - 0.13 12.3 0.2 0.78 9.8 0.1 2.4 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF2062 PF09835.7 001279651.1_37529001_3 - 0.16 11.7 9.4 2.7 7.7 0.1 3.5 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2062) HAD PF12710.5 001279651.1_37529001_3 - 0.19 12.0 0.0 0.38 11.0 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase 7tm_1 PF00001.19 001311324.1_37523001_1 - 2.6e-53 180.8 20.3 4.6e-53 180.1 20.3 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001311324.1_37523001_1 - 4.6e-06 26.1 15.6 9.5e-06 25.0 15.6 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001311324.1_37523001_1 - 0.00054 19.7 17.8 0.0012 18.6 17.8 1.6 1 1 0 1 1 1 1 Olfactory receptor Transglut_N PF00868.18 001279479.1_37525001_1 - 9.6e-25 87.1 0.0 2.8e-24 85.6 0.0 1.8 1 0 0 1 1 1 1 Transglutaminase family Transglut_C PF00927.20 001279479.1_37525001_1 - 3.2e-23 81.7 0.0 1.5e-15 57.1 0.0 2.5 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.17 001279479.1_37525001_1 - 4.4e-18 65.6 0.1 9.3e-18 64.6 0.1 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily DEAD PF00270.27 001279610.1_37525001_3 - 2.4e-49 167.4 0.0 4.3e-49 166.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001279610.1_37525001_3 - 8.7e-30 103.2 0.0 2.1e-29 102.0 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 001279610.1_37525001_3 - 0.054 13.4 0.0 0.16 11.9 0.0 1.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DM PF00751.16 001279481.1_37524001_3 - 1.4e-22 79.2 9.9 2.3e-22 78.5 9.9 1.4 1 0 0 1 1 1 1 DM DNA binding domain DMA PF03474.12 001279481.1_37524001_3 - 2.3e-15 55.7 0.0 4.8e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 DMRTA motif MACPF PF01823.17 001282898.1_37524001_2 - 4.5e-37 128.0 0.0 6.4e-37 127.6 0.0 1.2 1 0 0 1 1 1 1 MAC/Perforin domain TSP_1 PF00090.17 001282898.1_37524001_2 - 9.2e-10 38.5 21.5 0.00013 22.0 9.6 3.1 2 0 0 2 2 2 2 Thrombospondin type 1 domain Ldl_recept_a PF00057.16 001282898.1_37524001_2 - 3.4e-08 33.4 8.4 3.4e-08 33.4 8.4 2.9 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A Thyroglob_assoc PF16597.3 001282898.1_37524001_3 - 0.037 14.2 0.0 0.077 13.2 0.0 1.5 1 0 0 1 1 1 0 Thyroglobulin_1 repeat associated disordered domain Collagen PF01391.16 001282889.1_37529001_2 - 1.9e-158 514.2 718.9 3.3e-10 39.4 28.9 20.7 2 1 18 20 20 20 20 Collagen triple helix repeat (20 copies) COLFI PF01410.16 001282889.1_37529001_2 - 1.9e-109 364.3 0.4 2.4e-109 364.0 0.4 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain VWC PF00093.16 001282889.1_37529001_2 - 1.2e-12 47.8 14.4 1.9e-12 47.2 14.4 1.3 1 0 0 1 1 1 1 von Willebrand factor type C domain TILa PF12714.5 001282889.1_37529001_2 - 0.038 13.8 6.9 0.025 14.4 4.7 1.8 2 0 0 2 2 2 0 TILa domain Amnionless PF14828.4 001282889.1_37529001_2 - 1.3 7.7 11.5 1.9 7.1 11.5 1.1 1 0 0 1 1 1 0 Amnionless PIG-P PF08510.10 001282889.1_37529001_3 - 4.1 7.2 5.4 2.1 8.2 0.3 3.0 2 0 0 2 2 2 0 PIG-P Hormone_recep PF00104.28 001279615.1_37527001_2 - 3.3e-31 108.4 6.5 5.8e-31 107.6 6.5 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001279615.1_37527001_2 - 1.3e-26 92.7 14.0 1.3e-26 92.7 14.0 2.1 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Androgen_recep PF02166.14 001279615.1_37527001_2 - 1.6e-05 23.8 0.7 2.7e-05 23.1 0.7 1.3 1 0 0 1 1 1 1 Androgen receptor DUF2625 PF10946.6 001279615.1_37527001_2 - 0.15 10.9 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF2625 OAD_gamma PF04277.11 001279615.1_37527001_2 - 8.6 6.9 6.4 6.9 7.2 4.3 1.9 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain p450 PF00067.20 001279489.1_37526001_3 - 2.2e-108 362.9 0.0 2.6e-108 362.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 3Beta_HSD PF01073.17 001279509.1_37524001_2 - 3.2e-94 314.9 0.0 4.2e-94 314.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 001279509.1_37524001_2 - 4.6e-19 68.7 0.0 7e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 001279509.1_37524001_2 - 2.1e-14 53.5 0.1 6.4e-13 48.6 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.10 001279509.1_37524001_2 - 1.6e-13 50.3 0.0 3.4e-13 49.2 0.0 1.5 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.13 001279509.1_37524001_2 - 9.6e-12 44.5 0.0 1.4e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.4 001279509.1_37524001_2 - 4e-06 26.7 0.0 5.6e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 001279509.1_37524001_2 - 0.00013 21.1 0.0 0.00042 19.4 0.0 1.7 1 1 0 1 1 1 1 RmlD substrate binding domain KR PF08659.8 001279509.1_37524001_2 - 0.0062 16.3 0.0 0.016 15.0 0.0 1.6 1 1 0 1 1 1 1 KR domain NmrA PF05368.11 001279509.1_37524001_2 - 0.019 14.4 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family Basic PF01586.14 001279721.1_37523001_3 - 3.4e-21 76.1 1.1 3.4e-21 76.1 1.1 2.2 2 0 0 2 2 2 1 Myogenic Basic domain Myf5 PF12232.6 001279721.1_37523001_3 - 2.7e-20 72.8 17.9 6.2e-20 71.6 17.9 1.6 1 0 0 1 1 1 1 Myogenic determination factor 5 HLH PF00010.24 001279721.1_37523001_3 - 2.9e-15 55.8 2.1 5e-15 55.1 2.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain 7tm_1 PF00001.19 001279621.1_37527001_2 - 8.5e-29 100.5 20.0 8.5e-29 100.5 20.0 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.4 001279621.1_37527001_2 - 3.3e-12 45.8 0.0 1.2e-06 28.1 0.0 3.7 2 1 1 3 3 3 3 Leucine rich repeat LRR_5 PF13306.4 001279621.1_37527001_2 - 4.8e-10 39.4 0.0 1.4e-05 25.0 0.1 2.3 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001279621.1_37527001_2 - 0.0088 16.3 0.0 11 6.5 0.0 4.4 4 1 0 4 4 4 1 Leucine Rich repeats (2 copies) Comm PF15957.3 001279621.1_37527001_2 - 0.035 14.3 0.5 0.1 12.8 0.5 1.8 1 0 0 1 1 1 0 Commissureless TGFb_propeptide PF00688.16 001311325.1_37523001_3 - 2.7e-39 135.3 1.4 3.4e-39 134.9 1.4 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001311325.1_37523001_3 - 7.9e-24 84.4 3.7 1.7e-23 83.3 3.7 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain EpoR_lig-bind PF09067.8 001279622.1_37525001_2 - 1.1e-17 64.0 0.5 2.2e-17 63.0 0.1 1.7 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding IL6Ra-bind PF09240.8 001279622.1_37525001_2 - 4.3e-07 30.1 0.0 9.4e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding Pur_ac_phosph_N PF16656.3 001279622.1_37525001_2 - 0.0017 18.8 1.5 0.0017 18.8 1.5 2.0 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.15 001279622.1_37525001_2 - 0.018 14.7 1.2 0.094 12.4 0.0 2.3 2 0 0 2 2 2 0 Tissue factor ACOX PF01756.17 001290199.1_37526001_3 - 4.4e-64 215.2 0.9 7.4e-64 214.5 0.9 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.4 001290199.1_37526001_3 - 4.1e-35 120.9 0.2 1.2e-34 119.5 0.0 1.8 2 0 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.17 001290199.1_37526001_3 - 7.5e-11 42.0 0.0 1.4e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.22 001290199.1_37526001_3 - 0.0027 17.8 0.1 0.0059 16.7 0.1 1.6 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain FOXP-CC PF16159.3 001282893.1_37523001_3 - 7.9e-30 103.2 0.8 2.3e-29 101.7 0.8 1.9 1 0 0 1 1 1 1 FOXP coiled-coil domain Forkhead PF00250.16 001282893.1_37523001_3 - 1.6e-26 92.3 0.3 4.4e-26 90.9 0.3 1.8 1 0 0 1 1 1 1 Forkhead domain NSP2-B_epitope PF14757.4 001282893.1_37523001_3 - 0.043 13.4 0.3 0.077 12.5 0.3 1.3 1 0 0 1 1 1 0 Immunogenic region of nsp2 protein of arterivirus polyprotein Trypsin PF00089.24 001279677.1_37523001_1 - 1.9e-64 217.4 2.1 2.3e-64 217.1 2.1 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001279677.1_37523001_1 - 2.2e-09 38.2 0.2 3e-09 37.8 0.2 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001279677.1_37523001_1 - 0.004 17.4 0.0 0.0075 16.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Hormone_6 PF00236.16 001279751.1_37521001_3 - 6.7e-49 163.7 10.6 7.9e-49 163.5 10.6 1.1 1 0 0 1 1 1 1 Glycoprotein hormone Hormone_2 PF00123.18 001279522.1_37523001_2 - 6.7e-18 64.2 1.1 7.6e-12 44.9 0.2 2.6 2 0 0 2 2 2 2 Peptide hormone GST_N PF02798.18 001279635.1_37523001_1 - 1.7e-15 57.0 0.0 3.4e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001279635.1_37523001_1 - 8.2e-14 51.5 0.0 1.5e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 001279635.1_37523001_1 - 1.3e-12 47.6 0.0 2.4e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001279635.1_37523001_1 - 0.0084 16.3 0.0 0.016 15.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 001279635.1_37523001_1 - 0.18 11.6 0.0 0.43 10.4 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Ig_2 PF13895.4 001311343.1_37523001_1 - 3e-14 53.0 3.4 8.3e-09 35.6 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001311343.1_37523001_1 - 2.6e-13 50.2 9.3 1.2e-08 35.3 0.4 3.4 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 001311343.1_37523001_1 - 8.9e-09 35.3 9.9 0.0034 17.4 0.4 4.4 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 001311343.1_37523001_1 - 1.5e-06 28.2 11.4 0.045 13.8 0.1 4.6 2 1 2 4 4 4 4 Immunoglobulin V-set domain I-set PF07679.14 001311343.1_37523001_1 - 1.9e-06 27.7 3.9 5.6e-05 23.0 0.3 3.4 4 1 0 4 4 4 1 Immunoglobulin I-set domain C2-set_2 PF08205.10 001311343.1_37523001_1 - 4.7e-05 23.3 2.2 0.0066 16.4 0.6 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain DUF3876 PF12992.5 001311343.1_37523001_1 - 0.026 14.5 0.0 0.1 12.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3876) MFS_1 PF07690.14 001311343.1_37523001_1 - 0.085 11.6 0.1 0.21 10.3 0.0 1.6 2 0 0 2 2 2 0 Major Facilitator Superfamily Cpn60_TCP1 PF00118.22 001279708.1_37524001_1 - 9.5e-150 499.3 10.3 1.1e-149 499.1 10.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF2529 PF10740.7 001279708.1_37524001_1 - 0.016 14.7 0.2 0.041 13.4 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF2529) Zona_pellucida PF00100.21 001279646.1_37526001_2 - 1.9e-42 145.6 10.0 1.9e-42 145.6 10.0 2.9 3 1 0 4 4 4 1 Zona pellucida-like domain C8 PF08742.9 001279646.1_37526001_2 - 4.8e-14 52.4 3.7 4.8e-14 52.4 3.7 3.7 3 0 0 3 3 3 1 C8 domain ecTbetaR2 PF08917.8 001279646.1_37526001_2 - 0.0021 17.8 0.2 0.0021 17.8 0.2 4.2 4 1 1 5 5 5 1 Transforming growth factor beta receptor 2 ectodomain Metallophos PF00149.26 001279686.1_37524001_1 - 8.2e-33 114.5 0.3 1.3e-32 113.8 0.3 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 001279686.1_37524001_1 - 0.019 15.3 0.2 0.041 14.2 0.2 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain HGWP PF03578.13 001279686.1_37524001_1 - 0.16 11.6 2.2 0.28 10.7 0.1 2.6 2 0 0 2 2 2 0 HGWP repeat Trypsin PF00089.24 001279777.1_37522001_1 - 1.7e-79 266.6 3.5 1.9e-79 266.4 3.5 1.0 1 0 0 1 1 1 1 Trypsin GTP_EFTU PF00009.25 001279647.1_37524001_2 - 2.1e-53 180.6 0.0 3.2e-53 180.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 001279647.1_37524001_2 - 1.8e-41 140.8 0.0 4.9e-41 139.4 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.23 001279647.1_37524001_2 - 3.8e-14 52.7 0.4 1.3e-13 51.0 0.4 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 001279647.1_37524001_2 - 0.0015 18.5 0.2 0.035 14.1 0.2 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.4 001279647.1_37524001_2 - 0.017 15.0 0.9 0.053 13.4 0.1 2.1 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Semialdhyde_dhC PF02774.16 001279647.1_37524001_2 - 0.055 13.4 0.0 0.16 11.9 0.0 1.8 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, dimerisation domain Peptidase_C14 PF00656.20 001282894.1_37526001_2 - 2.9e-46 158.3 0.1 3.8e-46 157.9 0.1 1.2 1 0 0 1 1 1 1 Caspase domain Peptidase_S10 PF00450.20 001311320.1_37523001_1 - 2.4e-133 445.5 0.5 2.7e-133 445.3 0.5 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Rad51 PF08423.9 001279450.1_37524001_3 - 8.2e-129 428.2 0.0 1.1e-128 427.8 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.4 001279450.1_37524001_3 - 5e-10 39.1 0.0 7.2e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain RecA PF00154.19 001279450.1_37524001_3 - 2.6e-09 36.8 0.1 4e-09 36.2 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.4 001279450.1_37524001_3 - 1.6e-07 31.7 0.9 5.4e-07 30.0 1.2 1.7 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.11 001279450.1_37524001_3 - 0.00012 21.4 0.7 0.0004 19.7 0.7 1.9 1 1 0 1 1 1 1 KaiC HHH PF00633.21 001279450.1_37524001_3 - 0.046 13.5 0.1 0.1 12.3 0.1 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif PAXNEB PF05625.9 001279450.1_37524001_3 - 0.13 11.2 0.0 0.24 10.4 0.0 1.3 1 0 0 1 1 1 0 PAXNEB protein Gln-synt_C PF00120.22 001279668.1_37524001_1 - 6.8e-17 61.3 0.0 9.1e-12 44.5 0.0 2.3 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.17 001279668.1_37524001_1 - 1.2e-12 47.2 0.0 2.2e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain GYF PF02213.14 001311316.1_37523001_1 - 4.1e-19 67.9 5.0 1.1e-18 66.5 5.0 1.8 1 0 0 1 1 1 1 GYF domain DUF4339 PF14237.4 001311316.1_37523001_1 - 0.049 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4339) MAS20 PF02064.13 001311316.1_37523001_1 - 3.8 7.5 7.7 1.3 9.0 3.5 2.2 2 0 0 2 2 2 0 MAS20 protein import receptor PIEZO PF15917.3 001311316.1_37523001_2 - 0.19 11.0 6.6 0.34 10.2 6.6 1.4 1 0 0 1 1 1 0 Piezo Furin-like_2 PF15913.3 001319025.1_23522001_1 - 2.2e-45 153.1 23.7 2.2e-45 153.1 23.7 1.8 2 0 0 2 2 2 1 Furin-like repeat, cysteine-rich DUF1510 PF07423.9 001319025.1_23522001_1 - 3.3 6.9 13.4 4.3 6.6 13.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) RR_TM4-6 PF06459.10 001319025.1_23522001_1 - 4 7.1 13.9 5.6 6.6 13.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_C65 PF10275.7 001002411.1_16123001_1 - 2.5e-85 285.7 1.3 3.6e-85 285.2 1.3 1.2 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.17 001002411.1_16123001_1 - 2.7e-05 24.5 0.1 0.0018 18.6 0.1 2.4 1 1 0 1 1 1 1 OTU-like cysteine protease RE_XcyI PF09571.8 001002411.1_16123001_1 - 0.053 12.6 0.0 0.083 12.0 0.0 1.2 1 0 0 1 1 1 0 XcyI restriction endonuclease Keratin PF02422.14 001001310.4_23522001_2 - 5.1e-35 118.9 10.6 5.1e-35 118.9 10.6 1.9 2 0 0 2 2 2 1 Keratin TIL PF01826.15 001001310.4_23522001_2 - 3 8.0 17.6 0.079 13.1 8.7 2.6 3 0 0 3 3 3 0 Trypsin Inhibitor like cysteine rich domain PMP22_Claudin PF00822.18 204660.2_23524001_1 - 4.7e-55 185.8 0.6 7.7e-55 185.1 0.6 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 204660.2_23524001_1 - 3.7e-19 69.1 1.8 6.3e-19 68.3 0.4 1.9 2 0 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction ETC_C1_NDUFA5 PF04716.12 001097637.1_23523001_3 - 6.8e-26 89.7 0.5 1e-25 89.2 0.5 1.3 1 0 0 1 1 1 1 ETC complex I subunit conserved region Thioredoxin_7 PF13899.4 001293249.1_02221001_1 - 1e-24 86.4 0.5 2e-24 85.4 0.2 1.6 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.4 001293249.1_02221001_1 - 2.4e-06 27.8 0.7 7.9e-06 26.2 0.7 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredox_DsbH PF03190.13 001293249.1_02221001_1 - 4.2e-06 26.7 0.1 6e-06 26.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Peptidase_S24 PF00717.21 001005802.1_23523001_1 - 3.1e-09 36.5 0.1 4.9e-09 35.9 0.1 1.3 1 0 0 1 1 1 1 Peptidase S24-like Doppel PF11466.6 001079487.1_23524001_2 - 0.016 14.7 0.7 0.043 13.4 0.7 1.8 1 0 0 1 1 1 0 Prion-like protein Doppel C1q PF00386.19 001079487.1_23524001_3 - 5.3e-23 81.5 0.6 8.1e-23 80.9 0.6 1.3 1 0 0 1 1 1 1 C1q domain Myosin_head PF00063.19 204766.2_23529001_2 - 1.7e-288 958.4 0.0 1.7e-288 958.4 0.0 2.9 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 204766.2_23529001_2 - 4.4e-163 544.6 265.2 5.3e-163 544.3 265.2 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 204766.2_23529001_2 - 7.5e-17 60.7 5.0 2.2e-16 59.3 5.0 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Filament PF00038.19 204766.2_23529001_2 - 0.00066 19.2 48.7 0.00066 19.2 48.7 7.9 1 1 7 8 8 8 5 Intermediate filament protein DUF1664 PF07889.10 204766.2_23529001_2 - 0.0015 18.4 145.3 0.03 14.2 8.0 13.3 2 2 8 13 13 13 8 Protein of unknown function (DUF1664) Reo_sigmaC PF04582.10 204766.2_23529001_2 - 0.0088 15.3 77.3 0.25 10.6 5.4 8.9 2 2 8 10 10 10 6 Reovirus sigma C capsid protein AAA_22 PF13401.4 204766.2_23529001_2 - 0.088 13.0 0.0 0.088 13.0 0.0 6.0 3 2 2 5 5 5 0 AAA domain IQ PF00612.25 204766.2_23529001_2 - 0.13 12.0 3.5 4.6 7.2 0.6 2.9 2 0 0 2 2 2 0 IQ calmodulin-binding motif AAA_16 PF13191.4 204766.2_23529001_2 - 0.2 11.9 0.0 0.2 11.9 0.0 5.8 4 3 1 5 5 5 0 AAA ATPase domain Lectin_C PF00059.19 001044682.1_23522001_1 - 1.1e-13 51.7 7.3 1.1e-13 51.7 7.3 1.6 2 0 0 2 2 2 1 Lectin C-type domain CEBP_ZZ PF16366.3 001044682.1_23522001_1 - 0.028 14.5 0.8 0.092 12.9 0.8 1.9 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Ly49 PF08391.8 001044682.1_23522001_1 - 0.11 12.7 1.3 0.2 11.9 0.0 2.2 2 1 0 2 2 2 0 Ly49-like protein, N-terminal region tRNA_edit PF04073.13 001195561.1_23522001_1 - 2.8e-26 91.9 0.0 3.6e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain PRORP PF16953.3 001195561.1_23522001_1 - 0.06 12.7 0.2 0.084 12.2 0.2 1.1 1 0 0 1 1 1 0 Protein-only RNase P NDK PF00334.17 001257371.2_23525001_2 - 1.5e-34 118.7 0.0 2.3e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Dpy-30 PF05186.11 001257371.2_23525001_2 - 1.1e-17 63.3 0.4 1.9e-17 62.5 0.4 1.5 1 0 0 1 1 1 1 Dpy-30 motif NTPase_1 PF03266.13 001031523.1_23524001_1 - 1.2e-64 217.1 0.2 1.6e-64 216.7 0.2 1.1 1 0 0 1 1 1 1 NTPase AAA_16 PF13191.4 001031523.1_23524001_1 - 4.4e-05 23.8 0.0 6.9e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.10 001031523.1_23524001_1 - 7.2e-05 22.6 0.0 0.00017 21.4 0.0 1.6 2 0 0 2 2 1 1 NACHT domain AAA PF00004.27 001031523.1_23524001_1 - 0.00014 22.1 0.1 0.00039 20.7 0.1 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 001031523.1_23524001_1 - 0.00016 21.5 0.0 0.0021 17.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.4 001031523.1_23524001_1 - 0.00024 21.3 0.1 0.0011 19.2 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.4 001031523.1_23524001_1 - 0.00057 19.5 0.1 0.0019 17.8 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.4 001031523.1_23524001_1 - 0.0014 18.9 0.2 0.0068 16.6 0.2 1.9 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.10 001031523.1_23524001_1 - 0.0029 16.8 0.0 0.0048 16.1 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus TsaE PF02367.15 001031523.1_23524001_1 - 0.014 15.2 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.20 001031523.1_23524001_1 - 0.015 15.6 0.0 0.04 14.2 0.0 1.7 2 0 0 2 2 1 0 RNA helicase AAA_33 PF13671.4 001031523.1_23524001_1 - 0.022 14.8 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.4 001031523.1_23524001_1 - 0.022 15.1 0.0 0.042 14.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.4 001031523.1_23524001_1 - 0.028 14.3 0.0 0.83 9.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.4 001031523.1_23524001_1 - 0.032 13.8 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.20 001031523.1_23524001_1 - 0.035 13.0 0.0 0.057 12.3 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain ATPase_2 PF01637.16 001031523.1_23524001_1 - 0.039 13.7 0.0 0.072 12.9 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF2478 PF10649.7 001031523.1_23524001_1 - 0.044 13.3 0.1 0.57 9.6 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2478) Mg_chelatase PF01078.19 001031523.1_23524001_1 - 0.052 12.8 0.0 0.099 11.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI cobW PF02492.17 001031523.1_23524001_1 - 0.055 12.9 0.0 0.098 12.1 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.21 001031523.1_23524001_1 - 0.056 13.4 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_32 PF13654.4 001031523.1_23524001_1 - 0.059 12.0 0.0 0.085 11.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.4 001031523.1_23524001_1 - 0.066 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain ArgK PF03308.14 001031523.1_23524001_1 - 0.074 11.9 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 ArgK protein AAA_29 PF13555.4 001031523.1_23524001_1 - 0.16 11.6 0.0 0.37 10.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_11 PF13086.4 001031523.1_23524001_1 - 0.19 11.3 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Rad52_Rad22 PF04098.13 001167758.1_23525001_1 - 3.6e-49 166.5 0.0 7.9e-49 165.4 0.0 1.5 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein KRAB PF01352.25 001318982.1_23526001_3 - 3e-17 61.9 0.1 5.9e-17 60.9 0.1 1.5 1 0 0 1 1 1 1 KRAB box zf-AD PF07776.13 001318982.1_23526001_3 - 0.19 11.8 5.3 4.8 7.4 1.5 3.0 2 1 0 2 2 2 0 Zinc-finger associated domain (zf-AD) TPX2_importin PF12214.6 204437.1_23526001_1 - 7.2e-50 169.3 73.9 1.7e-38 132.4 10.6 8.0 5 3 2 7 7 7 5 Cell cycle regulated microtubule associated protein Aurora-A_bind PF09041.8 204437.1_23526001_1 - 3.1e-26 91.1 0.4 9.4e-26 89.5 0.4 1.8 1 0 0 1 1 1 1 Aurora-A binding TPX2 PF06886.9 204437.1_23526001_1 - 2.9e-13 49.7 20.2 2.9e-13 49.7 20.2 6.8 8 0 0 8 8 8 1 Targeting protein for Xklp2 (TPX2) Sec62 PF03839.14 001025530.1_16123001_3 - 3.5e-76 255.4 3.5 3.5e-76 255.4 3.5 2.7 2 1 1 3 3 2 1 Translocation protein Sec62 DUF1510 PF07423.9 001025530.1_16123001_3 - 4.6e-05 22.8 6.1 4.6e-05 22.8 6.1 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF1510) DEP PF00610.19 001025530.1_16123001_3 - 0.024 14.6 0.0 0.092 12.7 0.0 2.0 1 0 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Ctr PF04145.13 001025530.1_16123001_3 - 0.043 14.3 0.7 0.043 14.3 0.7 3.0 2 1 1 3 3 2 0 Ctr copper transporter family SET PF00856.26 001025530.1_16123001_3 - 0.1 12.9 5.2 0.42 10.8 1.3 2.3 2 0 0 2 2 2 0 SET domain BSP_II PF05432.9 001025530.1_16123001_3 - 0.19 11.2 39.7 0.95 9.0 9.8 2.2 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) CNDH2_C PF16858.3 001025530.1_16123001_3 - 0.89 9.3 31.4 1.1 9.0 11.7 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SID-1_RNA_chan PF13965.4 001025530.1_16123001_3 - 4.1 5.6 13.9 0.42 8.9 0.0 2.2 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 SpoIIIAH PF12685.5 001025530.1_16123001_3 - 5.1 6.7 34.7 0.15 11.7 8.1 2.4 2 0 0 2 2 2 0 SpoIIIAH-like protein Dsh_C PF12316.6 001025530.1_16123001_3 - 6 7.1 21.4 1.9 8.7 2.1 2.5 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal SAPS PF04499.13 001025530.1_16123001_3 - 7.8 5.0 29.9 0.1 11.2 6.4 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein VID27 PF08553.8 001025530.1_16123001_3 - 9.7 4.4 30.4 0.014 13.9 7.9 2.3 2 0 0 2 2 2 0 VID27 cytoplasmic protein Sp38 PF07354.10 001279552.1_37524001_1 - 0.057 12.2 0.3 0.085 11.6 0.3 1.1 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) Gp_dh_C PF02800.18 001279552.1_37524001_3 - 3.9e-70 234.4 0.0 6.5e-70 233.7 0.0 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.22 001279552.1_37524001_3 - 4.5e-36 123.1 0.0 8.8e-36 122.2 0.0 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.17 001279552.1_37524001_3 - 0.0054 16.0 0.0 0.0094 15.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Lectin_C PF00059.19 001080714.1_23522001_2 - 2.6e-14 53.8 1.4 4.3e-14 53.0 1.4 1.4 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 001080714.1_23522001_2 - 0.009 15.5 1.1 0.016 14.7 1.1 1.4 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like SLC3A2_N PF16028.3 001080714.1_23522001_2 - 2.5 7.6 5.7 0.38 10.2 1.2 1.9 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus MMR_HSR1 PF01926.21 001257373.1_23523001_1 - 2.9e-15 56.2 0.0 2.2e-13 50.2 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.14 001257373.1_23523001_1 - 3.2e-08 33.5 0.1 7.9e-07 29.0 0.1 2.2 1 1 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.16 001257373.1_23523001_1 - 4.6e-07 29.4 0.1 6.6e-05 22.4 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B IIGP PF05049.11 001257373.1_23523001_1 - 0.00085 18.3 0.0 0.0012 17.8 0.0 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) PduV-EutP PF10662.7 001257373.1_23523001_1 - 0.00086 18.9 0.0 1.3 8.6 0.0 2.4 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.25 001257373.1_23523001_1 - 0.0025 17.2 0.1 0.54 9.6 0.0 2.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.14 001257373.1_23523001_1 - 0.0034 16.6 0.0 0.0056 15.9 0.0 1.4 1 0 0 1 1 1 1 AIG1 family AAA_16 PF13191.4 001257373.1_23523001_1 - 0.0034 17.7 0.8 0.042 14.1 0.1 2.4 1 1 2 3 3 3 1 AAA ATPase domain Dynamin_N PF00350.21 001257373.1_23523001_1 - 0.0083 16.1 0.8 0.42 10.5 0.2 2.3 1 1 1 2 2 2 1 Dynamin family AAA_22 PF13401.4 001257373.1_23523001_1 - 0.016 15.3 0.1 0.19 11.9 0.0 2.3 1 1 1 2 2 2 0 AAA domain Roc PF08477.11 001257373.1_23523001_1 - 0.035 14.2 0.1 0.15 12.2 0.0 2.0 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.4 001257373.1_23523001_1 - 0.039 14.3 0.1 0.079 13.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain Ras PF00071.20 001257373.1_23523001_1 - 0.12 11.9 0.0 4.3 6.8 0.0 2.2 2 0 0 2 2 2 0 Ras family cobW PF02492.17 001257373.1_23523001_1 - 0.13 11.7 0.1 1.4 8.3 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.4 001257373.1_23523001_1 - 0.13 11.9 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Peripla_BP_2 PF01497.16 001257373.1_23523001_1 - 0.16 11.4 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein ATP_bind_1 PF03029.15 001257373.1_23523001_1 - 0.17 11.5 0.1 18 4.9 0.0 2.6 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein Septin PF00735.16 001257373.1_23523001_1 - 0.18 10.9 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 Septin Collagen PF01391.16 001282897.1_37529001_1 - 5.6e-160 519.1 692.4 8e-11 41.4 27.9 21.0 2 1 17 19 19 19 16 Collagen triple helix repeat (20 copies) COLFI PF01410.16 001282897.1_37529001_1 - 1.9e-108 361.0 0.1 2.4e-108 360.7 0.1 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain HlyIII PF03006.18 001008462.1_23526001_2 - 2.8e-49 167.7 16.1 5.9e-49 166.7 16.1 1.6 1 0 0 1 1 1 1 Haemolysin-III related Thioredoxin_7 PF13899.4 001293116.1_02222001_1 - 9.8e-26 89.6 0.1 2.1e-25 88.6 0.1 1.6 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.4 001293116.1_02222001_1 - 0.001 19.4 0.1 0.0057 17.0 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredox_DsbH PF03190.13 001293116.1_02222001_1 - 0.026 14.3 0.0 0.035 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF255 V-set PF07686.15 001080870.1_23523001_1 - 9.9e-24 83.5 5.5 2.6e-13 49.9 1.1 2.5 2 0 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.23 001080870.1_23523001_1 - 3.4e-09 36.6 5.1 0.00011 22.1 0.3 3.2 2 1 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001080870.1_23523001_1 - 9.5e-08 32.4 9.4 0.00034 21.0 0.4 3.0 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 001080870.1_23523001_1 - 1.8e-06 27.8 2.6 0.034 14.1 0.5 2.9 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 001080870.1_23523001_1 - 0.00024 21.3 3.5 0.015 15.5 1.0 2.7 2 1 0 2 2 2 1 Immunoglobulin domain Izumo-Ig PF16706.3 001080870.1_23523001_1 - 0.013 15.4 0.1 0.59 10.1 0.0 2.4 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain TMEM51 PF15345.4 001080870.1_23523001_1 - 0.015 15.0 0.4 0.05 13.3 0.1 2.0 2 0 0 2 2 2 0 Transmembrane protein 51 SIT PF15330.4 001080870.1_23523001_1 - 0.02 15.1 0.5 0.081 13.2 0.0 2.3 3 0 0 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT Internalin_N PF12354.6 001080870.1_23523001_1 - 0.14 12.2 1.3 6.1 6.9 0.0 2.8 2 1 0 2 2 2 0 Bacterial adhesion/invasion protein N terminal Peptidase_C12 PF01088.19 001279698.1_37524001_3 - 1.9e-57 194.3 0.1 2.3e-57 194.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Vitellogenin_N PF01347.20 001322804.1_23526001_3 - 4.3e-43 147.5 0.0 5.9e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 Lipoprotein amino terminal region DUF1943 PF09172.9 001322804.1_23526001_3 - 0.0004 19.6 0.2 0.0017 17.6 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1943) HEAT_2 PF13646.4 001322804.1_23526001_3 - 0.079 13.2 0.2 0.27 11.5 0.2 1.9 1 0 0 1 1 1 0 HEAT repeats Collagen PF01391.16 001279444.1_37529001_2 - 1.7e-168 546.4 718.3 1.3e-11 43.9 26.8 20.6 2 1 16 18 18 18 16 Collagen triple helix repeat (20 copies) COLFI PF01410.16 001279444.1_37529001_2 - 3.1e-114 379.9 0.5 4.2e-114 379.5 0.5 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain VWC PF00093.16 001279444.1_37529001_2 - 1.2e-11 44.6 14.7 1.2e-11 44.6 14.7 1.9 2 0 0 2 2 2 1 von Willebrand factor type C domain TILa PF12714.5 001279444.1_37529001_2 - 1.3 8.9 10.9 0.16 11.8 5.9 2.0 2 0 0 2 2 2 0 TILa domain WD40_4 PF16300.3 001006176.2_23527001_2 - 5.9e-37 125.2 1.5 1.8e-17 62.8 0.3 2.5 2 0 0 2 2 2 2 Type of WD40 repeat WD40 PF00400.30 001006176.2_23527001_2 - 9.8e-26 89.4 5.6 8.4e-05 23.1 0.0 7.8 8 0 0 8 8 8 5 WD domain, G-beta repeat DUF1899 PF08953.9 001006176.2_23527001_2 - 4e-23 81.0 0.0 3.3e-11 42.8 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.5 001006176.2_23527001_2 - 1.7e-13 50.5 0.0 0.00096 19.3 0.0 4.1 2 2 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001006176.2_23527001_2 - 0.035 12.9 0.0 0.24 10.2 0.0 2.3 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF974 PF06159.11 001006577.2_23524001_1 - 8.8e-85 284.3 0.4 1.2e-84 283.8 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF974) Trs65 PF12735.5 001006577.2_23524001_1 - 0.00056 19.3 0.0 2.1 7.5 0.0 3.2 2 1 1 3 3 3 2 TRAPP trafficking subunit Trs65 Transglut_C PF00927.20 001006577.2_23524001_1 - 0.0074 16.3 0.3 0.071 13.1 0.0 2.5 3 0 0 3 3 3 1 Transglutaminase family, C-terminal ig like domain ELP6 PF09807.7 001277490.1_23523001_3 - 1.4e-109 365.2 0.9 1.8e-109 364.9 0.9 1.1 1 0 0 1 1 1 1 Elongation complex protein 6 Arm PF00514.21 001031150.2_23526001_1 - 2.7e-33 112.8 18.2 9.7e-08 31.7 0.1 8.4 8 1 1 9 9 9 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 001031150.2_23526001_1 - 6.7e-05 23.1 8.0 0.037 14.4 0.0 4.8 5 0 0 5 5 5 2 HEAT-like repeat HEAT_2 PF13646.4 001031150.2_23526001_1 - 0.0013 18.9 5.6 6.7 7.0 0.5 4.7 2 1 3 5 5 5 2 HEAT repeats WAPL PF07814.11 001031150.2_23526001_1 - 0.0045 15.8 16.7 0.076 11.7 0.1 4.3 3 1 0 4 4 4 2 Wings apart-like protein regulation of heterochromatin HEAT PF02985.20 001031150.2_23526001_1 - 0.0082 16.2 1.2 11 6.5 0.1 4.3 3 0 0 3 3 3 2 HEAT repeat V-ATPase_H_C PF11698.6 001031150.2_23526001_1 - 0.027 14.5 8.5 1.5 8.8 0.7 4.5 3 2 2 5 5 5 0 V-ATPase subunit H Atx10homo_assoc PF09759.7 001031150.2_23526001_1 - 0.66 9.9 4.7 16 5.5 0.1 4.3 4 1 0 4 4 4 0 Spinocerebellar ataxia type 10 protein domain DUF498 PF04430.12 001278102.2_23523001_3 - 2.7e-19 69.1 0.0 7e-19 67.8 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF498/DUF598) Phospholip_A2_1 PF00068.17 001184757.1_23521001_1 - 9.9e-36 122.4 15.8 1.2e-35 122.2 15.8 1.1 1 0 0 1 1 1 1 Phospholipase A2 Spin-Ssty PF02513.15 001184757.1_23521001_2 - 0.15 11.7 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 Spin/Ssty Family PCMT PF01135.17 001277402.1_23523001_3 - 6.1e-82 274.3 0.0 1.1e-81 273.5 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.4 001277402.1_23523001_3 - 3e-06 27.7 0.0 7.1e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001277402.1_23523001_3 - 7.3e-06 25.7 0.0 1.5e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001277402.1_23523001_3 - 0.0002 21.8 0.0 0.00051 20.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain GCD14 PF08704.8 001277402.1_23523001_3 - 0.00029 20.5 0.0 0.00043 19.9 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Ubie_methyltran PF01209.16 001277402.1_23523001_3 - 0.00035 19.8 0.0 0.00062 19.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.12 001277402.1_23523001_3 - 0.049 13.0 0.0 0.092 12.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.4 001277402.1_23523001_3 - 0.12 12.2 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.4 001277402.1_23523001_3 - 0.14 11.9 0.0 0.33 10.7 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain ALG11_N PF15924.3 001199825.1_23524001_3 - 2.1e-93 312.0 0.1 2.9e-93 311.6 0.1 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.18 001199825.1_23524001_3 - 4.2e-28 97.9 0.0 7e-28 97.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.4 001199825.1_23524001_3 - 2.7e-13 50.4 0.0 6e-13 49.2 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.4 001199825.1_23524001_3 - 0.0041 17.4 0.0 0.0087 16.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.4 001199825.1_23524001_3 - 0.0061 16.4 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 DUF4999 PF16390.3 001199825.1_23524001_3 - 0.11 12.6 0.2 0.26 11.3 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function SIR2 PF02146.15 075081.1_23522120_2 - 2.7e-06 27.3 0.1 4.7e-06 26.5 0.1 1.4 1 0 0 1 1 1 1 Sir2 family SIR2 PF02146.15 075081.1_23522120_3 - 3.5e-11 43.2 0.0 4.5e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Sir2 family PNTB PF02233.14 075081.1_23522120_3 - 0.0027 16.6 0.0 0.0037 16.1 0.0 1.0 1 0 0 1 1 1 1 NAD(P) transhydrogenase beta subunit PAS_3 PF08447.10 001319008.1_23526001_1 - 6.2e-19 67.9 0.0 1.8e-11 44.0 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 001319008.1_23526001_1 - 4.2e-14 52.5 0.0 5e-10 39.4 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS PF00989.23 001319008.1_23526001_1 - 5.5e-09 35.9 0.0 2.1e-08 34.0 0.0 1.9 2 0 0 2 2 2 1 PAS fold HLH PF00010.24 001319008.1_23526001_1 - 7.7e-05 22.4 0.0 0.00017 21.4 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 001319008.1_23526001_1 - 0.00031 20.8 0.0 0.0048 17.0 0.0 2.4 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.8 001319008.1_23526001_1 - 0.01 15.9 0.0 0.063 13.4 0.0 2.3 3 0 0 3 3 3 0 PAS fold Reticulon PF02453.15 001277087.2_23529001_3 - 5.1e-45 153.1 7.2 5.1e-45 153.1 7.2 2.1 2 0 0 2 2 2 1 Reticulon Reticulon PF02453.15 001348287.1_23529001_1 - 9.8e-45 152.2 7.2 9.8e-45 152.2 7.2 1.9 2 0 0 2 2 2 1 Reticulon Lectin_C PF00059.19 001329217.1_23522001_3 - 9.7e-12 45.5 4.7 1.5e-11 44.9 4.7 1.3 1 0 0 1 1 1 1 Lectin C-type domain ERM PF00769.17 204497.2_23524001_1 - 1.1e-72 244.7 52.6 1.1e-72 244.7 52.6 2.2 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_M PF00373.16 204497.2_23524001_1 - 5.3e-27 94.4 0.9 5.3e-27 94.4 0.9 3.3 2 1 0 3 3 3 1 FERM central domain FERM_C PF09380.8 204497.2_23524001_1 - 7.5e-25 87.0 0.4 4.9e-24 84.4 0.0 2.7 3 0 0 3 3 3 1 FERM C-terminal PH-like domain FERM_N PF09379.8 204497.2_23524001_1 - 9.6e-12 44.5 2.8 4.1e-11 42.5 0.3 2.8 2 0 0 2 2 2 1 FERM N-terminal domain PINIT PF14324.4 001030626.1_23529001_3 - 5.4e-35 120.8 0.0 9.1e-35 120.0 0.0 1.4 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.18 001030626.1_23529001_3 - 1.4e-21 75.9 5.2 3.3e-21 74.6 5.2 1.7 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 001030626.1_23529001_3 - 0.00051 19.7 1.6 0.0014 18.3 1.6 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.25 001030626.1_23529001_3 - 0.06 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 SAP domain zf-C3HC4_2 PF13923.4 001012889.1_23527001_2 - 5.5e-10 38.8 5.1 5.5e-10 38.8 5.1 3.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001012889.1_23527001_2 - 1.3e-09 37.8 3.7 4.9e-09 35.9 3.7 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 001012889.1_23527001_2 - 2.6e-09 37.1 5.6 2.6e-09 37.1 5.6 3.5 5 0 0 5 5 3 1 Ring finger domain zf-C3HC4 PF00097.23 001012889.1_23527001_2 - 4.3e-08 32.8 5.3 4.3e-08 32.8 5.3 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001012889.1_23527001_2 - 8.5e-08 31.9 6.2 8.5e-08 31.9 6.2 3.1 4 0 0 4 4 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 001012889.1_23527001_2 - 6.4e-07 29.0 6.5 6.4e-07 29.0 6.5 4.5 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001012889.1_23527001_2 - 4.8e-06 26.2 3.8 4.8e-06 26.2 3.8 3.5 3 1 1 4 4 3 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.5 001012889.1_23527001_2 - 0.00038 20.5 5.3 0.0018 18.4 5.3 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain Rtf2 PF04641.10 001012889.1_23527001_2 - 0.019 14.2 0.2 0.032 13.5 0.2 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger zf-C3HC4_4 PF15227.4 001012889.1_23527001_2 - 0.052 13.6 11.7 0.037 14.1 7.2 3.2 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-UDP PF14569.4 001012889.1_23527001_2 - 0.1 12.6 5.8 0.051 13.6 2.4 2.3 2 0 0 2 2 2 0 Zinc-binding RING-finger DZR PF12773.5 001012889.1_23527001_2 - 0.2 11.6 6.4 0.14 12.1 3.7 2.3 2 0 0 2 2 1 0 Double zinc ribbon RINGv PF12906.5 001286369.1_23528001_3 - 4.8e-15 55.3 16.6 1.3e-14 53.9 16.6 1.8 1 0 0 1 1 1 1 RING-variant domain DctQ PF04290.10 001286369.1_23528001_3 - 0.021 14.6 1.1 0.045 13.5 1.1 1.5 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component zf-C3HC4_3 PF13920.4 001030711.1_23527001_1 - 1.9e-11 43.5 11.9 1.9e-11 43.5 11.9 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Armet PF10208.7 001030711.1_23527001_1 - 1.9e-05 24.5 0.9 0.12 12.1 0.1 2.3 2 0 0 2 2 2 2 Degradation arginine-rich protein for mis-folding FYVE_2 PF02318.14 001030711.1_23527001_1 - 0.00088 19.3 6.0 0.00088 19.3 6.0 2.4 2 0 0 2 2 2 1 FYVE-type zinc finger Prok-RING_4 PF14447.4 001030711.1_23527001_1 - 0.0074 16.0 11.9 0.0074 16.0 11.9 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 SAP PF02037.25 001030711.1_23527001_1 - 0.014 15.0 0.4 1.7 8.3 0.1 2.5 2 0 0 2 2 2 0 SAP domain zf-RING_5 PF14634.4 001030711.1_23527001_1 - 2.4 8.1 36.8 0.023 14.5 12.0 2.9 3 0 0 3 3 3 0 zinc-RING finger domain SAP PF02037.25 001030603.2_23524001_1 - 2.1e-10 40.0 0.2 5.3e-10 38.7 0.2 1.7 1 0 0 1 1 1 1 SAP domain zf-C3HC4_2 PF13923.4 001030603.2_23524001_1 - 8e-09 35.1 8.2 8e-09 35.1 8.2 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001030603.2_23524001_1 - 4.8e-07 29.4 9.7 4.8e-07 29.4 9.7 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 001030603.2_23524001_1 - 1.8e-06 27.5 5.4 1.8e-06 27.5 5.4 3.0 3 0 0 3 3 3 1 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.4 001030603.2_23524001_1 - 1.2e-05 24.9 12.3 4e-05 23.3 9.1 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001030603.2_23524001_1 - 7.7e-05 22.8 12.2 7.7e-05 22.8 12.2 3.2 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.4 001030603.2_23524001_1 - 0.0038 17.0 18.0 0.0039 17.0 13.1 3.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 001030603.2_23524001_1 - 0.0042 16.9 10.4 0.0042 16.9 10.4 2.5 3 0 0 3 3 2 1 RING-type zinc-finger PRP21_like_P PF12230.6 001030603.2_23524001_1 - 0.0071 16.1 0.1 0.0071 16.1 0.1 2.0 2 0 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein zf-RING_10 PF16685.3 001030603.2_23524001_1 - 0.019 15.0 5.7 0.074 13.1 5.7 2.1 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-rbx1 PF12678.5 001030603.2_23524001_1 - 0.021 14.9 8.1 0.021 14.9 8.1 3.1 3 0 0 3 3 3 0 RING-H2 zinc finger domain LEM PF03020.13 001030603.2_23524001_1 - 0.065 12.7 0.3 0.13 11.7 0.3 1.4 1 0 0 1 1 1 0 LEM domain GAT PF03127.12 001030603.2_23524001_1 - 0.25 11.5 3.2 1.3 9.2 0.1 3.1 2 1 2 4 4 4 0 GAT domain zf-UBR PF02207.18 212629.1_16125001_2 - 6e-13 48.6 9.0 6e-13 48.6 9.0 3.6 3 2 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) WD-3 PF09765.7 001033941.1_23524001_3 - 9.4e-116 386.0 0.3 1.1e-115 385.7 0.3 1.1 1 0 0 1 1 1 1 WD-repeat region FANCL_C PF11793.6 001033941.1_23524001_3 - 2.9e-33 113.7 3.0 5.1e-33 112.9 3.0 1.4 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.4 001033941.1_23524001_3 - 6.2e-06 26.2 3.8 1.4e-05 25.1 3.8 1.7 1 0 0 1 1 1 1 Ring finger domain zf-HC5HC2H PF13771.4 001033941.1_23524001_3 - 0.024 14.7 0.2 0.048 13.8 0.2 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-rbx1 PF12678.5 001033941.1_23524001_3 - 0.047 13.9 2.2 0.13 12.4 2.2 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.5 001033941.1_23524001_3 - 0.063 13.2 2.9 0.24 11.4 2.9 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.4 001033941.1_23524001_3 - 1.6 8.6 4.8 2.3 8.1 1.7 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PINIT PF14324.4 001031456.1_23524001_1 - 1.3e-39 135.7 0.2 3.8e-39 134.2 0.2 1.8 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.18 001031456.1_23524001_1 - 8.1e-21 73.4 5.0 1.6e-20 72.4 5.0 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 001031456.1_23524001_1 - 0.00023 20.8 1.5 0.00057 19.5 1.5 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Peptidase_M42 PF05343.12 001031456.1_23524001_1 - 0.12 11.2 0.1 0.19 10.6 0.1 1.1 1 0 0 1 1 1 0 M42 glutamyl aminopeptidase zf-C3HC4 PF00097.23 001031456.1_23524001_1 - 0.92 9.3 4.9 3.1 7.6 4.9 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) UPF0544 PF15749.3 001031456.1_23524001_1 - 3.5 8.2 8.7 67 4.1 8.7 2.3 1 1 0 1 1 1 0 Uncharacterised protein family UPF0544 LRV_FeS PF05484.9 001031456.1_23524001_3 - 0.031 14.2 0.8 0.066 13.1 0.8 1.5 1 0 0 1 1 1 0 LRV protein FeS4 cluster Ribosomal_L19e PF01280.18 001030929.1_23522001_3 - 5.9e-67 224.1 11.2 5.9e-67 224.1 11.2 1.9 1 1 1 2 2 2 1 Ribosomal protein L19e IL8 PF00048.18 001030712.1_23521001_1 - 2.4e-21 75.5 0.6 2.9e-21 75.3 0.6 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Ctr PF04145.13 001277685.1_23522001_2 - 2.7e-27 96.1 1.0 5.1e-27 95.2 1.0 1.5 1 1 0 1 1 1 1 Ctr copper transporter family Lectin_C PF00059.19 001100002.1_16123001_2 - 1.1e-43 148.2 26.4 3.3e-17 63.0 6.7 3.1 3 0 0 3 3 3 3 Lectin C-type domain Xlink PF00193.15 001100002.1_16123001_2 - 0.0034 17.6 4.8 10 6.4 0.0 4.0 3 1 0 3 3 3 2 Extracellular link domain UL45 PF05473.10 001100002.1_16123001_2 - 0.014 14.9 0.3 0.46 10.0 0.0 2.4 2 1 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like IF3_N PF05198.14 001100002.1_16123001_2 - 0.062 13.5 0.1 2.3 8.4 0.0 2.3 2 0 0 2 2 2 0 Translation initiation factor IF-3, N-terminal domain MORN PF02493.18 001122702.1_16125001_1 - 3.1e-35 117.8 64.6 2.9e-07 29.8 1.9 8.8 8 0 0 8 8 8 8 MORN repeat Alanine_zipper PF11839.6 001122702.1_16125001_1 - 0.16 12.1 15.4 0.39 10.9 15.4 1.6 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein BAMBI PF06211.10 001195401.2_23522001_1 - 5.4e-62 206.6 10.1 5.4e-62 206.6 10.1 1.5 2 0 0 2 2 2 1 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain DUF1049 PF06305.9 001195401.2_23522001_1 - 0.058 13.1 0.9 0.1 12.3 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) EphA2_TM PF14575.4 001195401.2_23522001_1 - 0.1 13.3 0.1 0.28 11.9 0.1 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain JIP_LZII PF16471.3 001195401.2_23522001_1 - 0.1 12.6 0.5 14 5.8 0.0 2.3 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II RhoGEF PF00621.18 001267535.1_23529001_1 - 5.6e-45 153.7 3.1 4.3e-44 150.8 3.4 2.5 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.27 001267535.1_23529001_1 - 1.9e-16 60.3 2.7 9.1e-15 54.9 0.2 3.0 3 0 0 3 3 3 1 PH domain PH_9 PF15410.4 001267535.1_23529001_1 - 3.4e-10 40.2 0.2 1.1e-09 38.5 0.2 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PDZ PF00595.22 001267535.1_23529001_1 - 1.5e-09 38.0 0.0 3.2e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001267535.1_23529001_1 - 0.0029 17.8 0.0 0.0089 16.2 0.0 1.8 1 0 0 1 1 1 1 PDZ domain RBD PF02196.13 001267535.1_23529001_1 - 0.003 17.5 0.0 0.0081 16.1 0.0 1.7 1 0 0 1 1 1 1 Raf-like Ras-binding domain PH_13 PF16652.3 001267535.1_23529001_1 - 0.035 13.9 0.3 0.36 10.6 0.0 2.8 3 0 0 3 3 3 0 Pleckstrin homology domain PH_11 PF15413.4 001267535.1_23529001_1 - 0.036 14.4 0.1 0.16 12.2 0.1 2.2 1 0 0 1 1 1 0 Pleckstrin homology domain eIF_4EBP PF05456.9 001321634.1_23523001_1 - 1.7e-38 131.0 0.6 2.6e-38 130.3 0.6 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Forkhead PF00250.16 001321535.1_23526001_1 - 1.5e-35 121.2 0.2 2.7e-35 120.4 0.2 1.4 1 0 0 1 1 1 1 Forkhead domain ECH_1 PF00378.18 001252606.1_23525001_3 - 8.8e-58 195.4 0.2 1.3e-57 194.9 0.2 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 001252606.1_23525001_3 - 1.8e-29 103.2 0.2 5.7e-29 101.5 0.2 1.6 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase Lectin_C PF00059.19 001025480.1_16122001_1 - 1.2e-25 90.1 12.5 4.2e-14 53.1 2.5 2.1 2 0 0 2 2 2 2 Lectin C-type domain UL45 PF05473.10 001025480.1_16122001_1 - 0.00022 20.8 0.1 0.0017 17.9 0.0 2.0 1 1 1 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like Xlink PF00193.15 001025480.1_16122001_1 - 0.003 17.8 0.2 2.4 8.5 0.0 2.8 2 1 1 3 3 3 2 Extracellular link domain Viral_cys_rich PF08008.10 001025480.1_16122001_1 - 0.0056 16.6 0.1 0.29 11.1 0.0 2.5 2 0 0 2 2 2 1 Viral cysteine rich Homeobox PF00046.27 001003563.1_16124001_3 - 5e-21 74.1 1.8 1.2e-20 73.0 1.8 1.7 1 0 0 1 1 1 1 Homeobox domain MAP17 PF15807.3 001003563.1_16124001_3 - 8.4 6.5 8.7 18 5.4 0.2 2.3 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 FIST_C PF10442.7 001030545.1_23527001_1 - 2.5e-11 43.5 0.1 5.7e-11 42.4 0.1 1.6 1 0 0 1 1 1 1 FIST C domain F-box PF00646.31 001030545.1_23527001_1 - 5.6e-06 26.0 0.7 1.4e-05 24.7 0.7 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.5 001030545.1_23527001_1 - 4.5e-05 23.1 1.3 9.9e-05 22.0 1.3 1.6 1 0 0 1 1 1 1 F-box-like BAP PF06639.9 001030545.1_23527001_2 - 0.11 12.7 1.0 0.28 11.3 1.0 1.6 1 0 0 1 1 1 0 Basal layer antifungal peptide (BAP) DUF1356 PF07092.10 001012558.1_23526001_2 - 1.2e-114 381.2 5.1 1.2e-114 381.2 5.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1356) DUF59 PF01883.17 001030555.1_23528001_3 - 1.2e-05 25.2 0.1 2.2e-05 24.4 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF59 Zw10 PF06248.11 001303453.1_23527001_2 - 3.2e-237 788.6 13.4 4.3e-237 788.2 13.4 1.1 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 COG5 PF10392.7 001303453.1_23527001_2 - 0.009 16.1 0.2 0.043 13.9 0.1 2.2 1 1 0 1 1 1 1 Golgi transport complex subunit 5 Reovirus_M2 PF05993.10 001303453.1_23527001_2 - 0.036 12.0 0.0 0.061 11.3 0.0 1.2 1 0 0 1 1 1 0 Reovirus major virion structural protein Mu-1/Mu-1C (M2) ALO PF04030.12 001303453.1_23527001_2 - 0.12 12.0 0.1 0.64 9.6 0.0 2.1 2 0 0 2 2 2 0 D-arabinono-1,4-lactone oxidase DUF4363 PF14276.4 001303453.1_23527001_2 - 0.19 11.7 9.3 2.2 8.2 0.6 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4363) Flagellin_C PF00700.19 001303453.1_23527001_2 - 0.58 10.4 0.0 0.58 10.4 0.0 2.6 3 0 0 3 3 3 0 Bacterial flagellin C-terminal helical region Sec8_exocyst PF04048.12 001303453.1_23527001_2 - 1.5 8.6 5.1 0.74 9.6 0.1 3.0 4 0 0 4 4 4 0 Sec8 exocyst complex component specific domain COX7a PF02238.13 001277587.1_23523001_1 - 9.1e-08 32.3 0.0 1.8e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII T-box_assoc PF16176.3 001321555.1_23527001_3 - 3.9e-109 363.9 3.4 5.8e-109 363.3 3.4 1.3 1 0 0 1 1 1 1 T-box transcription factor-associated T-box PF00907.20 001321555.1_23527001_3 - 2e-75 252.9 0.5 2.8e-75 252.4 0.5 1.2 1 0 0 1 1 1 1 T-box NqrM PF04400.11 001321555.1_23527001_3 - 0.024 14.3 1.0 0.05 13.2 1.0 1.5 1 0 0 1 1 1 0 (Na+)-NQR maturation NqrM UQ_con PF00179.24 001006180.1_23523001_1 - 1.3e-44 151.2 0.3 1.6e-44 150.8 0.3 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.20 001006180.1_23523001_1 - 0.00016 21.8 0.1 0.00035 20.7 0.1 1.6 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.4 001006180.1_23523001_1 - 0.00024 20.7 0.0 0.00034 20.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.11 001006180.1_23523001_1 - 0.00024 20.8 0.1 0.00041 20.1 0.1 1.4 1 0 0 1 1 1 1 UEV domain Ank_2 PF12796.5 001277405.1_23522001_1 - 5.9e-25 87.5 1.4 1.1e-11 45.0 0.2 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001277405.1_23522001_1 - 6.5e-24 83.9 3.6 2.7e-07 30.9 0.1 4.2 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.4 001277405.1_23522001_1 - 1.4e-21 76.1 4.7 5.7e-11 42.3 0.3 3.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.28 001277405.1_23522001_1 - 2.7e-19 68.6 4.4 0.00014 22.0 0.1 5.9 5 1 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.4 001277405.1_23522001_1 - 6.5e-16 56.7 4.0 0.00041 20.5 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat PDZ_2 PF13180.4 001006189.1_23523001_3 - 3e-10 40.1 0.0 4.6e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.22 001006189.1_23523001_3 - 9.9e-05 22.5 0.0 0.00018 21.7 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) GRASP55_65 PF04495.12 001006189.1_23523001_3 - 0.0068 16.6 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain UCR_14kD PF02271.14 001326494.1_23524001_3 - 9.9e-39 131.2 1.3 1.4e-38 130.7 1.3 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit NDUF_B8 PF05821.9 001006502.1_23522001_3 - 1.3e-82 275.8 5.9 1.6e-82 275.6 5.9 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) dNK PF01712.17 001006451.1_23525001_3 - 6.4e-75 251.4 1.2 7.9e-75 251.1 1.2 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_28 PF13521.4 001006451.1_23525001_3 - 0.0002 21.5 0.0 0.00038 20.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 001006451.1_23525001_3 - 0.006 17.0 0.0 0.12 12.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.15 001006451.1_23525001_3 - 0.034 13.7 0.2 0.15 11.6 0.0 2.0 2 0 0 2 2 2 0 Thymidylate kinase AAA_33 PF13671.4 001006451.1_23525001_3 - 0.099 12.7 0.0 0.28 11.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain Tim44 PF04280.13 001193585.1_23523001_1 - 9.3e-31 106.8 0.0 1.5e-30 106.2 0.0 1.3 1 0 0 1 1 1 1 Tim44-like domain MBA1 PF07961.9 001193585.1_23523001_1 - 7.4e-05 21.8 0.0 0.00012 21.2 0.0 1.2 1 0 0 1 1 1 1 MBA1-like protein ChaB PF06150.10 001193585.1_23523001_1 - 0.088 13.3 0.6 0.23 12.0 0.1 2.0 2 0 0 2 2 2 0 ChaB DUF3678 PF12435.6 001193585.1_23523001_3 - 0.042 13.0 2.7 3.8 6.7 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) Tmemb_55A PF09788.7 001277420.1_23525001_3 - 1.5e-99 331.9 11.5 2.3e-99 331.3 11.5 1.3 1 0 0 1 1 1 1 Transmembrane protein 55A zf-BED PF02892.13 001277420.1_23525001_3 - 0.068 13.1 6.0 3.4 7.7 0.0 4.1 4 0 0 4 4 4 0 BED zinc finger Complex1_LYR PF05347.13 001278108.1_23522001_1 - 7e-11 41.9 0.4 1.3e-10 41.0 0.1 1.7 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 001278108.1_23522001_1 - 0.00072 20.1 0.8 0.00096 19.7 0.1 1.6 2 1 0 2 2 2 1 Complex1_LYR-like Lipocalin PF00061.21 001277416.1_23522001_3 - 2e-19 70.1 1.0 2.6e-19 69.7 1.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001277416.1_23522001_3 - 7.1e-05 22.6 0.3 9e-05 22.3 0.3 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family TRAM_LAG1_CLN8 PF03798.14 001317736.1_23525001_3 - 2.6e-15 56.6 5.7 2.6e-15 56.6 5.7 1.8 2 0 0 2 2 2 1 TLC domain bZIP_2 PF07716.13 001278110.2_23524001_3 - 2.3e-07 30.7 7.8 3.2e-07 30.2 7.8 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.19 001278110.2_23524001_3 - 0.00097 19.1 6.6 0.0015 18.4 6.6 1.3 1 0 0 1 1 1 1 bZIP transcription factor Daxx PF03344.13 001044949.1_16126001_2 - 1.8e-47 159.3 1.7 4.4e-47 158.1 1.7 1.7 1 0 0 1 1 1 1 Daxx N-terminal Rassf1C-interacting domain NADH_B2 PF14813.4 001277896.1_23522001_1 - 4.7e-34 115.9 4.0 6.4e-34 115.4 4.0 1.2 1 0 0 1 1 1 1 NADH dehydrogenase 1 beta subcomplex subunit 2 MARVEL PF01284.21 001199458.1_23524001_3 - 9.6e-35 119.6 12.8 1.3e-34 119.1 12.8 1.2 1 0 0 1 1 1 1 Membrane-associating domain RRM_1 PF00076.20 206986.2_23529001_2 - 5e-31 106.2 1.5 8.5e-09 35.0 0.0 5.2 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-Sec23_Sec24 PF04810.13 206986.2_23529001_2 - 0.0091 15.9 0.0 0.033 14.1 0.0 2.0 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Furin-like_2 PF15913.3 001319024.1_23522001_1 - 1.6e-47 160.0 25.2 1.6e-47 160.0 25.2 2.2 2 0 0 2 2 2 1 Furin-like repeat, cysteine-rich LSM PF01423.20 001277862.1_23522001_3 - 1.6e-19 69.2 0.2 2.7e-19 68.5 0.2 1.4 1 0 0 1 1 1 1 LSM domain TMEM52 PF14979.4 001277695.1_23522001_3 - 1.3e-05 25.0 10.4 9.9e-05 22.1 10.4 2.0 1 1 0 1 1 1 1 Transmembrane 52 WBP-1 PF11669.6 001277695.1_23522001_3 - 0.24 11.9 6.9 1.2 9.6 6.9 2.0 1 1 0 1 1 1 0 WW domain-binding protein 1 Ank_2 PF12796.5 001025492.1_16125001_1 - 7.5e-84 276.3 35.9 2.3e-17 63.2 0.2 8.2 2 2 6 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001025492.1_16125001_1 - 3.3e-73 241.1 20.1 1.1e-12 48.0 0.3 10.4 7 2 4 11 11 11 10 Ankyrin repeats (many copies) Ank_3 PF13606.4 001025492.1_16125001_1 - 1.1e-64 206.5 19.2 0.0012 19.0 0.0 16.1 16 0 0 16 16 16 15 Ankyrin repeat Ank PF00023.28 001025492.1_16125001_1 - 2.4e-63 207.8 43.2 1.5e-06 28.3 0.1 15.4 14 1 1 15 15 15 14 Ankyrin repeat Ank_5 PF13857.4 001025492.1_16125001_1 - 6.2e-49 163.1 31.6 2.8e-07 30.6 0.1 11.7 3 3 8 12 12 12 12 Ankyrin repeats (many copies) CARD PF00619.19 001025492.1_16125001_1 - 8.8e-11 41.6 0.3 1.5e-09 37.6 0.0 3.0 3 0 0 3 3 3 1 Caspase recruitment domain MYEOV2 PF15004.4 102421.1_23523120_2 - 2.5e-32 111.0 6.9 3.5e-32 110.4 6.9 1.2 1 0 0 1 1 1 1 Myeloma-overexpressed-like Transmemb_17 PF09799.7 075086.1_23523120_3 - 5.6e-29 100.7 15.3 5.6e-29 100.7 15.3 1.8 2 0 0 2 2 2 1 Predicted membrane protein DUF3043 PF11241.6 075086.1_23523120_3 - 0.34 10.8 9.9 1.7 8.5 1.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3043) MYEOV2 PF15004.4 102420.1_23523120_2 - 2.9e-32 110.7 6.9 4.1e-32 110.3 6.9 1.2 1 0 0 1 1 1 1 Myeloma-overexpressed-like CLASP_N PF12348.6 001177385.1_23529001_2 - 2e-53 181.2 4.8 2.6e-38 131.8 0.1 4.3 4 0 0 4 4 4 3 CLASP N terminal HEAT PF02985.20 001177385.1_23529001_2 - 4.3e-13 48.1 14.9 0.0028 17.6 0.0 10.1 12 0 0 12 12 11 3 HEAT repeat HEAT_EZ PF13513.4 001177385.1_23529001_2 - 3.2e-10 40.1 1.1 0.055 13.8 0.0 6.1 6 0 0 6 6 6 2 HEAT-like repeat HEAT_2 PF13646.4 001177385.1_23529001_2 - 1.3e-08 34.9 2.5 1.3 9.4 0.1 7.8 5 3 4 9 9 9 2 HEAT repeats Cnd1 PF12717.5 001177385.1_23529001_2 - 1.8e-07 31.1 6.0 0.051 13.4 0.5 5.9 5 2 2 7 7 7 2 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.7 001177385.1_23529001_2 - 0.00014 22.0 0.5 0.0028 17.7 0.1 2.8 1 1 1 2 2 2 1 Parkin co-regulated protein Vac14_Fab1_bd PF12755.5 001177385.1_23529001_2 - 0.00026 21.4 2.5 28 5.2 0.0 6.0 6 1 1 7 7 6 0 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.7 001177385.1_23529001_2 - 0.0003 20.8 2.6 0.85 9.7 0.1 3.8 3 1 1 4 4 3 2 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.18 001177385.1_23529001_2 - 0.00062 18.3 7.0 0.6 8.5 0.1 5.6 5 2 1 7 7 7 1 Adaptin N terminal region Sec7_N PF12783.5 001177385.1_23529001_2 - 0.00083 19.2 4.6 3.5 7.5 0.8 4.6 5 0 0 5 5 5 2 Guanine nucleotide exchange factor in Golgi transport N-terminal MMS19_N PF14500.4 001177385.1_23529001_2 - 0.00086 18.8 3.6 5.2 6.4 0.0 3.6 3 0 0 3 3 3 2 Dos2-interacting transcription regulator of RNA-Pol-II TAN PF11640.6 001177385.1_23529001_2 - 0.0062 16.6 1.0 0.12 12.4 0.1 3.4 2 0 0 2 2 2 1 Telomere-length maintenance and DNA damage repair TFCD_C PF12612.6 001177385.1_23529001_2 - 0.0068 16.1 2.4 0.14 11.9 0.1 4.0 6 0 0 6 6 5 1 Tubulin folding cofactor D C terminal Ipi1_N PF12333.6 001177385.1_23529001_2 - 0.028 14.9 1.3 0.32 11.5 0.0 3.4 3 0 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation MMS19_C PF12460.6 001177385.1_23529001_2 - 0.049 12.6 5.2 0.85 8.5 0.0 3.8 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal RINGv PF12906.5 001012906.1_23527001_3 - 6.9e-14 51.6 10.9 1.4e-13 50.6 10.9 1.6 1 0 0 1 1 1 1 RING-variant domain DUF2517 PF10725.7 001012906.1_23527001_3 - 0.0063 16.1 0.1 0.02 14.5 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2517) FANCL_C PF11793.6 001012906.1_23527001_3 - 0.14 12.2 5.4 0.32 11.1 5.4 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain Asp PF00026.21 001318427.1_23523001_1 - 3.5e-115 384.6 0.0 4.2e-115 384.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001318427.1_23523001_1 - 9.3e-12 45.4 0.5 5.9e-10 39.6 0.5 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001318427.1_23523001_1 - 5.1e-08 32.5 0.2 9.6e-08 31.6 0.2 1.4 1 0 0 1 1 1 1 A1 Propeptide TAXi_C PF14541.4 001318427.1_23523001_1 - 3.1e-05 23.6 0.0 6.9e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal PMP22_Claudin PF00822.18 204132.1_23522001_1 - 4.7e-41 140.3 0.0 7.3e-41 139.7 0.0 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 204132.1_23522001_1 - 3.7e-20 72.4 0.0 6.5e-20 71.6 0.0 1.4 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction AA_permease_2 PF13520.4 204132.1_23522001_1 - 0.001 17.9 0.2 0.0013 17.6 0.2 1.1 1 0 0 1 1 1 1 Amino acid permease DUF2269 PF10027.7 204132.1_23522001_1 - 0.015 15.2 0.1 0.039 13.9 0.0 1.6 2 0 0 2 2 2 0 Predicted integral membrane protein (DUF2269) DUF4199 PF13858.4 204132.1_23522001_1 - 0.037 14.3 0.0 0.066 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Not1 PF04054.13 001277133.1_23529001_1 - 5.4e-154 512.4 6.6 1.1e-153 511.3 6.6 1.6 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.3 001277133.1_23529001_1 - 1.1e-96 322.5 11.8 1.2e-95 319.1 8.9 3.0 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind PF16417.3 001277133.1_23529001_1 - 4.8e-84 280.1 0.4 1.3e-83 278.7 0.4 1.7 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.5 001277133.1_23529001_1 - 4e-55 185.6 7.8 3.6e-54 182.5 8.2 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.3 001277133.1_23529001_1 - 5.2e-54 182.3 0.0 1.3e-53 181.0 0.0 1.7 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat EF-hand_8 PF13833.4 001277133.1_23529001_1 - 0.18 11.5 0.1 0.54 9.9 0.1 1.9 1 1 0 1 1 1 0 EF-hand domain pair 7tm_1 PF00001.19 001142671.1_23523001_3 - 2.9e-78 262.7 13.6 3.7e-78 262.3 13.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001142671.1_23523001_3 - 2e-13 50.2 9.1 2.6e-13 49.8 9.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001142671.1_23523001_3 - 0.00035 19.9 7.4 0.00035 19.9 7.4 2.4 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001142671.1_23523001_3 - 0.11 12.1 8.3 1.3 8.6 8.3 2.4 1 1 0 1 1 1 0 Olfactory receptor 7TM_GPCR_Srw PF10324.7 001142671.1_23523001_3 - 0.19 10.8 11.5 0.7 9.0 10.7 2.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw DUF2254 PF10011.7 001142671.1_23523001_3 - 0.2 10.3 2.3 0.27 9.9 0.7 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2254) zf-LITAF-like PF10601.7 001142671.1_23523001_3 - 5 7.3 14.3 0.99 9.6 0.7 3.9 3 1 1 4 4 4 0 LITAF-like zinc ribbon domain Pkinase PF00069.23 001285499.1_23529001_3 - 8.5e-44 149.8 0.0 1.3e-43 149.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ribonuc_2-5A PF06479.10 001285499.1_23529001_3 - 1.9e-41 141.1 0.1 3e-41 140.4 0.1 1.3 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.15 001285499.1_23529001_3 - 3.2e-25 88.8 0.0 4.8e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PQQ_2 PF13360.4 001285499.1_23529001_3 - 7.8e-08 32.1 0.0 0.0091 15.5 0.0 2.3 2 0 0 2 2 2 2 PQQ-like domain APH PF01636.21 001285499.1_23529001_3 - 1.4e-05 25.0 0.3 0.042 13.6 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family PQQ PF01011.19 001285499.1_23529001_3 - 3.1e-05 23.6 1.4 0.17 11.7 0.0 3.7 5 0 0 5 5 5 2 PQQ enzyme repeat Kdo PF06293.12 001285499.1_23529001_3 - 0.0012 18.1 0.1 0.0021 17.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PQQ_3 PF13570.4 001285499.1_23529001_3 - 0.062 13.7 0.7 1.2 9.6 0.0 3.5 4 1 1 5 5 5 0 PQQ-like domain Spin-Ssty PF02513.15 001017864.2_16123001_1 - 1.1e-64 213.8 5.2 4.7e-22 77.3 0.1 3.2 3 0 0 3 3 3 3 Spin/Ssty Family Ribosomal_L4 PF00573.20 001017864.2_16123001_1 - 0.12 11.9 1.2 0.21 11.1 1.2 1.3 1 0 0 1 1 1 0 Ribosomal protein L4/L1 family zf-Di19 PF05605.10 001001767.2_23526001_2 - 2.3e-17 62.9 2.1 2.3e-17 62.9 2.1 3.5 3 1 0 3 3 2 1 Drought induced 19 protein (Di19), zinc-binding zf-RING_UBOX PF13445.4 001001767.2_23526001_2 - 3.6e-08 33.1 10.9 3.6e-08 33.1 10.9 3.3 3 0 0 3 3 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 001001767.2_23526001_2 - 3.4e-07 29.9 9.2 3.4e-07 29.9 9.2 4.4 5 1 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001001767.2_23526001_2 - 7e-07 28.9 11.1 7e-07 28.9 11.1 4.7 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001001767.2_23526001_2 - 2.1e-06 27.3 13.0 2.1e-06 27.3 13.0 3.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001001767.2_23526001_2 - 2.9e-06 27.3 11.9 2.9e-06 27.3 11.9 4.0 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_4 PF15227.4 001001767.2_23526001_2 - 5.4e-06 26.3 14.3 5.4e-06 26.3 14.3 4.0 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 001001767.2_23526001_2 - 7.3e-05 22.5 10.3 7.3e-05 22.5 10.3 3.6 3 1 0 3 3 3 1 zinc-RING finger domain U-box PF04564.13 001001767.2_23526001_2 - 0.059 13.4 0.0 0.29 11.2 0.0 2.0 2 0 0 2 2 2 0 U-box domain zf-RING_11 PF17123.3 001001767.2_23526001_2 - 7.5 6.2 11.7 0.58 9.8 4.6 3.0 2 0 0 2 2 2 0 RING-like zinc finger Prok-RING_4 PF14447.4 001001767.2_23526001_2 - 7.6 6.4 21.8 0.15 11.8 10.5 3.3 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 PRY PF13765.4 001099354.1_23524001_1 - 1.2e-21 75.9 0.1 2.8e-21 74.7 0.1 1.7 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 001099354.1_23524001_1 - 4.8e-15 55.6 0.1 8.7e-15 54.8 0.1 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 001099354.1_23524001_1 - 2.7e-11 43.3 14.5 6.5e-11 42.1 14.5 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.22 001099354.1_23524001_1 - 5.5e-10 39.1 0.5 5.5e-10 39.1 0.5 3.4 3 1 1 4 4 2 1 B-box zinc finger zf-C3HC4 PF00097.23 001099354.1_23524001_1 - 1.3e-09 37.6 12.8 3e-09 36.5 12.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001099354.1_23524001_1 - 4e-09 36.2 12.8 1e-08 34.9 12.8 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001099354.1_23524001_1 - 1.7e-08 34.0 13.9 4e-08 32.8 13.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001099354.1_23524001_1 - 9.1e-07 28.5 11.8 9.1e-07 28.5 11.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001099354.1_23524001_1 - 4e-06 26.9 14.6 4e-06 26.9 14.6 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 001099354.1_23524001_1 - 4.2e-06 26.5 13.2 4.2e-06 26.5 13.2 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-Nse PF11789.6 001099354.1_23524001_1 - 0.0007 19.2 6.1 0.0014 18.3 6.1 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 001099354.1_23524001_1 - 0.00086 19.0 5.4 0.0019 17.9 5.4 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein U-box PF04564.13 001099354.1_23524001_1 - 0.0012 18.8 0.0 0.0024 17.9 0.0 1.5 1 0 0 1 1 1 1 U-box domain DUF2390 PF09523.8 001099354.1_23524001_1 - 0.021 15.0 2.6 0.055 13.7 2.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2390) zf-ANAPC11 PF12861.5 001099354.1_23524001_1 - 0.048 13.6 6.7 0.096 12.6 6.7 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.3 001099354.1_23524001_1 - 0.071 12.7 3.6 0.23 11.1 3.6 2.0 1 0 0 1 1 1 0 RING-like zinc finger RRF PF01765.17 001099354.1_23524001_1 - 0.1 12.4 0.6 0.16 11.7 0.6 1.3 1 0 0 1 1 1 0 Ribosome recycling factor zf-RING_10 PF16685.3 001099354.1_23524001_1 - 1.3 9.0 15.5 0.027 14.5 7.0 2.5 3 0 0 3 3 3 0 zinc RING finger of MSL2 Baculo_IE-1 PF05290.9 001099354.1_23524001_1 - 3.9 7.3 6.9 8.1 6.3 6.9 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_2 PF13639.4 001030586.1_23525001_3 - 5e-11 42.5 6.3 5e-11 42.5 6.3 3.1 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001030586.1_23525001_3 - 1.5e-08 34.2 5.7 4.8e-08 32.6 5.7 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001030586.1_23525001_3 - 2.6e-08 33.6 2.4 7.5e-08 32.1 2.4 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001030586.1_23525001_3 - 2.6e-07 30.3 2.7 2.6e-07 30.3 2.7 2.6 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001030586.1_23525001_3 - 8.4e-07 29.1 4.0 8.4e-07 29.1 4.0 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 001030586.1_23525001_3 - 4.7e-06 26.3 4.7 4.7e-06 26.3 4.7 2.5 3 1 0 3 3 1 1 zinc-RING finger domain zf-RING_11 PF17123.3 001030586.1_23525001_3 - 7.5e-06 25.4 3.5 2e-05 24.1 3.5 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-ANAPC11 PF12861.5 001030586.1_23525001_3 - 0.0014 18.5 3.2 0.0014 18.5 3.2 2.5 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger T3SSipB PF16535.3 001030586.1_23525001_3 - 0.0031 17.9 0.8 0.0031 17.9 0.8 2.8 2 1 1 3 3 3 1 Type III cell invasion protein SipB Reo_sigmaC PF04582.10 001030586.1_23525001_3 - 0.11 11.7 4.9 1.1 8.4 0.5 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein HIP1_clath_bdg PF16515.3 001030586.1_23525001_3 - 0.23 12.0 34.7 0.1 13.1 8.7 3.3 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Syntaxin-6_N PF09177.9 001030586.1_23525001_3 - 1.1 9.7 13.0 1.7 9.1 1.7 2.9 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Spc7 PF08317.9 001030586.1_23525001_3 - 2.7 6.7 35.4 0.31 9.7 14.0 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein HMMR_N PF15905.3 001030586.1_23525001_3 - 3 7.1 40.4 2.6 7.3 14.2 2.5 1 1 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Nsp1_C PF05064.11 001030586.1_23525001_3 - 4.8 6.9 16.2 5.9 6.6 4.9 3.3 3 0 0 3 3 3 0 Nsp1-like C-terminal region RWD PF05773.20 001031259.1_23524001_1 - 1.2e-17 64.1 0.1 2e-17 63.4 0.1 1.4 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.4 001031259.1_23524001_1 - 1.4e-06 28.3 7.0 1.1e-05 25.4 7.0 2.4 1 1 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.3 001031259.1_23524001_1 - 1.2e-05 24.8 5.0 1.2e-05 24.8 5.0 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.4 001031259.1_23524001_1 - 0.00011 22.0 8.1 0.00028 20.6 8.1 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.4 001031259.1_23524001_1 - 0.0064 16.2 7.5 0.0081 15.8 3.4 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001031259.1_23524001_1 - 0.012 15.4 5.0 0.098 12.4 5.4 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001031259.1_23524001_1 - 0.055 13.4 7.7 0.047 13.6 1.1 2.5 2 0 0 2 2 2 0 RING-type zinc-finger zf-ANAPC11 PF12861.5 001031259.1_23524001_1 - 0.33 10.9 5.1 4.3 7.3 5.1 2.4 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zf_RING PF16744.3 001031259.1_23524001_1 - 0.64 10.0 4.3 1.8 8.6 4.3 1.7 1 1 0 1 1 1 0 KIAA1045 RING finger zf-rbx1 PF12678.5 001031259.1_23524001_1 - 2.3 8.4 11.3 20 5.5 11.0 2.6 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-B_box PF00643.22 001006224.1_23528001_3 - 8.4e-09 35.3 8.7 8.4e-09 35.3 8.7 3.4 3 1 0 3 3 2 1 B-box zinc finger MATH PF00917.24 001006224.1_23528001_3 - 1.2e-07 31.7 0.0 3e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 MATH domain zf-C3HC4_3 PF13920.4 001006224.1_23528001_3 - 2.9e-05 23.7 15.2 2.9e-05 23.7 15.2 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001006224.1_23528001_3 - 0.0043 16.7 17.1 0.0043 16.7 17.1 2.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Dynein_heavy PF03028.13 001006224.1_23528001_3 - 0.051 11.7 2.5 0.075 11.1 2.5 1.1 1 0 0 1 1 1 0 Dynein heavy chain and region D6 of dynein motor Baculo_PEP_C PF04513.10 001006224.1_23528001_3 - 0.11 12.4 4.6 1.4 8.8 2.0 3.1 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus MRFAP1 PF15155.4 001006224.1_23528001_3 - 0.23 11.9 3.3 0.23 11.9 1.5 1.9 2 0 0 2 2 2 0 MORF4 family-associated protein1 FUSC PF04632.10 001006224.1_23528001_3 - 0.24 9.8 2.8 0.4 9.0 2.8 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Apolipoprotein PF01442.16 001006224.1_23528001_3 - 1.4 8.6 16.2 0.029 14.1 6.0 2.6 3 0 0 3 3 3 0 Apolipoprotein A1/A4/E domain DUF148 PF02520.15 001006224.1_23528001_3 - 1.7 8.7 9.3 0.93 9.5 2.3 2.8 3 0 0 3 3 3 0 Domain of unknown function DUF148 DUF5071 PF16804.3 001006224.1_23528001_3 - 2.9 8.1 4.6 3.1 7.9 1.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5071) Spc7 PF08317.9 001006224.1_23528001_3 - 7 5.3 14.1 48 2.5 11.3 2.5 2 1 0 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.10 001006224.1_23528001_3 - 9.9 6.0 9.5 15 5.5 4.7 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) LRR_8 PF13855.4 001097539.1_23526001_2 - 1.3e-38 130.5 40.3 3.4e-13 49.0 3.7 5.9 2 1 4 6 6 6 6 Leucine rich repeat LRR_5 PF13306.4 001097539.1_23526001_2 - 1.8e-23 82.8 0.2 8.1e-11 41.8 1.9 4.3 2 1 2 4 4 3 3 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001097539.1_23526001_2 - 7.8e-21 73.6 52.7 8.7e-06 25.8 4.7 9.0 5 1 5 11 11 11 8 Leucine Rich repeats (2 copies) I-set PF07679.14 001097539.1_23526001_2 - 1.5e-15 56.9 0.1 6e-15 54.9 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001097539.1_23526001_2 - 2.4e-12 47.2 0.1 7.2e-12 45.6 0.0 1.9 2 0 0 2 2 1 1 Immunoglobulin domain LRR_9 PF14580.4 001097539.1_23526001_2 - 2.4e-11 43.3 25.1 0.0028 17.1 3.6 4.4 1 1 3 4 4 4 4 Leucine-rich repeat ig PF00047.23 001097539.1_23526001_2 - 9.7e-07 28.7 0.3 7e-06 26.0 0.0 2.4 3 0 0 3 3 2 1 Immunoglobulin domain Ig_2 PF13895.4 001097539.1_23526001_2 - 4e-06 26.9 0.0 2e-05 24.7 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain LRRCT PF01463.22 001097539.1_23526001_2 - 6e-05 23.2 0.1 0.00021 21.4 0.1 2.1 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain LRRNT PF01462.16 001097539.1_23526001_2 - 0.00032 20.1 1.0 0.00032 20.1 1.0 2.2 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain V-set PF07686.15 001097539.1_23526001_2 - 0.00062 19.8 0.0 0.0037 17.3 0.0 2.3 1 1 0 1 1 1 1 Immunoglobulin V-set domain fn3 PF00041.19 001097539.1_23526001_2 - 0.0015 18.7 1.0 0.003 17.7 1.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 001097539.1_23526001_2 - 0.0035 17.7 1.2 0.0091 16.4 1.2 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain LRR_1 PF00560.31 001097539.1_23526001_2 - 0.19 12.2 0.2 0.19 12.2 0.2 9.1 11 0 0 11 11 9 0 Leucine Rich Repeat LRR_6 PF13516.4 001097539.1_23526001_2 - 0.39 10.8 15.3 19 5.5 0.1 6.5 4 1 1 5 5 5 0 Leucine Rich repeat IL6Ra-bind PF09240.8 001044675.1_23524001_3 - 2.6e-08 34.0 0.1 3.8e-08 33.5 0.1 1.3 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding Ig_3 PF13927.4 001044675.1_23524001_3 - 0.0015 18.9 0.0 0.014 15.9 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain fn3 PF00041.19 001044675.1_23524001_3 - 0.0049 17.1 0.3 0.012 15.8 0.3 1.7 1 0 0 1 1 1 1 Fibronectin type III domain ig PF00047.23 001044675.1_23524001_3 - 0.028 14.4 0.0 0.38 10.8 0.0 2.4 2 1 0 2 2 2 0 Immunoglobulin domain Ig_2 PF13895.4 001044675.1_23524001_3 - 0.14 12.4 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain Lectin_C PF00059.19 204606.1_23522001_1 - 2e-21 76.6 1.3 2e-21 76.6 1.3 1.4 2 0 0 2 2 2 1 Lectin C-type domain 7tm_1 PF00001.19 001081501.1_23525001_3 - 1e-58 198.6 16.6 1.5e-58 198.0 16.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CholecysA-Rec_N PF09193.8 001081501.1_23525001_3 - 2.4e-31 107.4 0.9 4.8e-31 106.4 0.9 1.6 1 0 0 1 1 1 1 Cholecystokinin A receptor, N-terminal 7tm_4 PF13853.4 001081501.1_23525001_3 - 5.3e-09 36.1 10.5 5.3e-09 36.1 10.5 1.6 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001081501.1_23525001_3 - 1.8e-07 30.7 23.1 9.2e-07 28.4 23.1 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Kringle PF00051.16 205213.1_23525001_1 - 9e-110 359.1 45.1 1.7e-28 98.6 7.4 4.4 4 0 0 4 4 4 4 Kringle domain Trypsin PF00089.24 205213.1_23525001_1 - 1.7e-39 135.8 0.0 3e-39 135.0 0.0 1.4 1 0 0 1 1 1 1 Trypsin PAN_1 PF00024.24 205213.1_23525001_1 - 2.6e-11 43.2 1.3 6.8e-11 41.8 0.1 2.3 2 0 0 2 2 2 1 PAN domain PAN_4 PF14295.4 205213.1_23525001_1 - 0.0029 17.4 6.8 0.023 14.4 0.5 4.5 4 0 0 4 4 4 1 PAN domain DUF1986 PF09342.9 205213.1_23525001_1 - 0.038 14.3 0.0 0.064 13.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) PAN_2 PF08276.9 205213.1_23525001_1 - 0.052 13.5 0.1 0.052 13.5 0.1 3.1 3 0 0 3 3 3 0 PAN-like domain PDZ PF00595.22 204918.1_23529001_1 - 1.4e-44 150.2 8.1 3.1e-16 59.4 0.3 3.4 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 204918.1_23529001_1 - 4.3e-16 58.8 2.0 0.00027 21.1 0.1 3.7 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.19 204918.1_23529001_1 - 1.9e-12 47.1 0.0 3.6e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.15 204918.1_23529001_1 - 2.3e-07 30.2 0.5 3.3e-06 26.5 0.0 3.0 4 0 0 4 4 4 1 Variant SH3 domain SH3_1 PF00018.26 204918.1_23529001_1 - 0.00019 20.8 0.0 0.0036 16.8 0.0 2.9 2 0 0 2 2 2 1 SH3 domain 7tm_1 PF00001.19 204362.1_23523001_3 - 6e-58 196.1 15.8 6e-58 196.1 15.8 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 204362.1_23523001_3 - 1.4e-09 37.6 11.9 2.4e-09 36.8 11.9 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 204362.1_23523001_3 - 1.2e-05 25.1 14.5 2.1e-05 24.3 14.5 1.4 1 1 0 1 1 1 1 Olfactory receptor TctB PF07331.9 204362.1_23523001_3 - 5.4 7.2 16.8 2.1 8.5 4.4 3.0 2 1 1 3 3 3 0 Tripartite tricarboxylate transporter TctB family Tissue_fac PF01108.15 001328224.1_02223001_2 - 4.8e-20 71.2 0.4 5.9e-19 67.7 0.1 2.5 2 0 0 2 2 2 1 Tissue factor Interfer-bind PF09294.8 001328224.1_02223001_2 - 1.5e-11 44.4 0.2 4.3e-11 42.9 0.0 1.8 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.19 001328224.1_02223001_2 - 5.2e-07 29.8 3.2 0.00015 21.9 0.1 2.9 3 0 0 3 3 3 2 Fibronectin type III domain CENP-C_C PF11699.6 205051.1_23526001_1 - 1.5e-29 101.9 0.1 4.3e-29 100.4 0.1 1.8 2 0 0 2 2 2 1 Mif2/CENP-C like CENP_C_N PF15622.4 205051.1_23526001_1 - 8.5e-13 48.3 0.1 8.5e-13 48.3 0.1 4.8 3 2 1 4 4 4 1 Kinetochore assembly subunit CENP-C N-terminal Cupin_2 PF07883.9 205051.1_23526001_1 - 1e-05 25.0 0.0 2.6e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Cupin domain Tropomodulin PF03250.12 205027.1_23525001_1 - 1.8e-59 199.7 4.7 3.3e-59 198.8 4.7 1.4 1 0 0 1 1 1 1 Tropomodulin LRR_6 PF13516.4 205027.1_23525001_1 - 0.038 13.9 0.3 0.11 12.4 0.3 1.9 1 0 0 1 1 1 0 Leucine Rich repeat DUF3007 PF11460.6 205027.1_23525001_1 - 0.2 11.8 0.6 0.35 11.0 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3007) Dynamin_N PF00350.21 205329.1_23524001_1 - 3.9e-14 52.9 0.0 9.9e-13 48.3 0.0 2.4 2 1 0 2 2 2 1 Dynamin family EHD_N PF16880.3 205329.1_23524001_1 - 5.2e-10 38.9 0.0 1.3e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 N-terminal EH-domain containing protein MMR_HSR1 PF01926.21 205329.1_23524001_1 - 1.7e-08 34.4 0.0 3.8e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 205329.1_23524001_1 - 0.0018 18.0 0.0 0.23 11.2 0.0 3.3 4 0 0 4 4 4 1 Protein of unknown function, DUF258 Peptidase_M20 PF01546.26 001279542.1_37524001_3 - 2.4e-35 122.0 0.0 3.2e-35 121.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.12 001279542.1_37524001_3 - 2.1e-15 56.4 0.0 3.6e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain WG_beta_rep PF14903.4 001279542.1_37524001_3 - 0.035 14.3 0.0 0.27 11.4 0.0 2.3 2 0 0 2 2 2 0 WG containing repeat MARVEL PF01284.21 001122699.1_16123001_2 - 3.6e-15 56.1 15.7 7.4e-15 55.1 15.7 1.5 1 0 0 1 1 1 1 Membrane-associating domain DUF4481 PF14800.4 001122699.1_16123001_2 - 0.12 11.7 3.5 0.18 11.1 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4481) DUF4131 PF13567.4 001122699.1_16123001_2 - 6.7 6.1 10.6 13 5.2 10.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) TNFR_c6 PF00020.16 001083360.1_23524001_2 - 2.1e-10 40.7 19.8 3.1e-07 30.5 5.6 3.9 4 0 0 4 4 4 2 TNFR/NGFR cysteine-rich region Ephrin_rec_like PF07699.11 001083360.1_23524001_2 - 0.52 10.0 20.3 0.46 10.1 3.0 3.4 2 1 1 3 3 3 0 Putative ephrin-receptor like zf-piccolo PF05715.11 001083360.1_23524001_2 - 6.8 6.8 14.0 0.31 11.1 7.9 1.9 2 0 0 2 2 2 0 Piccolo Zn-finger Aconitase PF00330.18 204188.2_23527001_2 - 6.7e-155 516.4 0.0 8.5e-155 516.1 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.17 204188.2_23527001_2 - 2.7e-45 153.8 0.0 5.2e-45 152.9 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain Hemopexin PF00045.17 205061.1_23524001_3 - 5.6e-50 166.9 15.8 6.1e-17 61.2 0.1 5.4 5 0 0 5 5 5 4 Hemopexin Somatomedin_B PF01033.15 205061.1_23524001_3 - 1.1e-09 38.4 19.9 1.1e-09 38.4 19.9 1.9 2 0 0 2 2 2 1 Somatomedin B domain Sushi PF00084.18 204664.2_23524001_2 - 1.6e-53 179.0 31.3 1.8e-12 47.6 0.7 6.4 6 1 0 6 6 6 6 Sushi repeat (SCR repeat) ICAM_N PF03921.12 204664.2_23524001_2 - 0.011 15.3 0.1 0.092 12.3 0.1 2.3 2 0 0 2 2 2 0 Intercellular adhesion molecule (ICAM), N-terminal domain Phosphorylase PF00343.18 204392.1_23527001_1 - 0 1159.6 0.0 0 1159.4 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase Hormone_1 PF00103.18 001279786.1_37523001_3 - 1.1e-28 100.3 0.1 1.6e-28 99.8 0.1 1.1 1 0 0 1 1 1 1 Somatotropin hormone family MbtH PF03621.11 001001756.1_23524001_1 - 0.35 10.2 2.9 0.52 9.7 1.6 2.0 2 0 0 2 2 2 0 MbtH-like protein p450 PF00067.20 001001756.1_23524001_3 - 6.5e-116 387.7 0.1 7.6e-116 387.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 PDE6_gamma PF04868.10 204445.2_23522001_3 - 7.1e-48 160.7 0.4 1e-47 160.2 0.4 1.2 1 0 0 1 1 1 1 Retinal cGMP phosphodiesterase, gamma subunit Rabaptin PF03528.13 205057.1_23527001_1 - 1.3e-278 924.3 55.3 1.3e-278 924.3 55.3 2.9 2 1 1 3 3 3 1 Rabaptin Rab5-bind PF09311.9 205057.1_23527001_1 - 5.6e-134 446.2 64.2 5.6e-134 446.2 64.2 4.1 2 1 1 3 3 3 1 Rabaptin-like protein Fez1 PF06818.13 205057.1_23527001_1 - 0.0058 17.0 26.3 0.0058 17.0 26.3 5.4 2 2 3 5 5 5 2 Fez1 TruB_C_2 PF16198.3 205057.1_23527001_1 - 5.5 7.1 9.5 0.87 9.6 0.5 4.1 3 0 0 3 3 3 0 tRNA pseudouridylate synthase B C-terminal domain LIM PF00412.20 204271.1_23523001_1 - 2.8e-27 94.6 20.8 5.2e-15 55.3 9.0 2.4 2 0 0 2 2 2 2 LIM domain VWA PF00092.26 001024580.1_23526001_3 - 1.7e-81 272.5 0.1 3.1e-43 147.9 0.5 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.4 001024580.1_23526001_3 - 3.8e-32 111.0 0.0 1.3e-14 54.6 0.0 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain LCCL PF03815.17 001024580.1_23526001_3 - 9.4e-23 80.0 0.3 9.4e-23 80.0 0.3 1.8 2 0 0 2 2 2 1 LCCL domain VWA_CoxE PF05762.12 001024580.1_23526001_3 - 0.0013 18.0 0.0 0.036 13.3 0.0 2.3 2 0 0 2 2 2 1 VWA domain containing CoxE-like protein DUF1194 PF06707.9 001024580.1_23526001_3 - 0.0063 15.6 0.0 2.3 7.2 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF1194) Rxt3 PF08642.8 001024580.1_23526001_3 - 0.05 14.2 0.0 0.15 12.7 0.0 1.9 1 1 0 1 1 1 0 Histone deacetylation protein Rxt3 BRI3BP PF14965.4 001040120.2_23523001_2 - 5.5e-73 244.2 0.3 5.5e-73 244.2 0.3 1.3 2 0 0 2 2 2 1 Negative regulator of p53/TP53 CLZ PF16526.3 001040120.2_23523001_2 - 0.035 14.3 0.1 0.17 12.1 0.1 1.9 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels MgtE PF01769.14 001040120.2_23523001_2 - 0.15 12.3 4.1 0.3 11.3 4.1 1.5 1 0 0 1 1 1 0 Divalent cation transporter RNase_H PF00075.22 204998.1_23523001_2 - 9.2e-47 158.7 0.0 1.6e-46 158.0 0.0 1.3 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.14 204998.1_23523001_2 - 6e-20 71.1 3.9 1.2e-19 70.2 3.9 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.4 204998.1_23523001_2 - 9.3e-05 22.0 0.0 0.00029 20.4 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase-like 7tm_2 PF00002.22 001163248.1_23529001_1 - 2e-79 266.2 17.2 3.2e-79 265.6 17.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001163248.1_23529001_1 - 5.7e-13 48.8 4.3 1.6e-12 47.4 4.3 1.8 1 0 0 1 1 1 1 Hormone receptor domain Topoisom_I PF01028.18 205110.1_23528001_2 - 2e-102 341.2 3.6 2e-102 341.2 3.6 2.5 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.13 205110.1_23528001_2 - 5.8e-101 336.3 7.8 5.8e-101 336.3 7.8 5.0 4 1 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.4 205110.1_23528001_2 - 2.8e-33 113.5 0.8 1.3e-32 111.3 0.8 2.3 1 0 0 1 1 1 1 C-terminal topoisomerase domain TCR_zetazeta PF11628.6 001098611.1_23521001_3 - 2.8e-16 58.7 3.9 4.3e-16 58.1 3.9 1.3 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 zeta chain MHC_I_3 PF16497.3 001017412.1_23524001_1 - 8.7e-27 93.8 0.0 3.7e-26 91.7 0.0 1.8 2 0 0 2 2 2 1 MHC-I family domain C1-set PF07654.13 001017412.1_23524001_1 - 1.4e-13 50.9 0.0 2.4e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001017412.1_23524001_1 - 1.3e-12 47.5 0.0 1.9e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_3 PF13927.4 001017412.1_23524001_1 - 3.5e-05 24.2 0.0 6.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001017412.1_23524001_1 - 0.015 15.5 0.0 0.03 14.5 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain wnt PF00110.17 204887.1_23524001_1 - 9.7e-120 399.6 24.1 1.2e-119 399.3 24.1 1.1 1 0 0 1 1 1 1 wnt family Alveol-reg_P311 PF11092.6 205391.1_23524001_3 - 8e-36 121.9 0.0 1.4e-35 121.0 0.0 1.4 1 0 0 1 1 1 1 Neuronal protein 3.1 (p311) Lig_chan PF00060.24 001279478.1_37527001_3 - 7.3e-58 194.5 0.1 1.2e-57 193.8 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel ANF_receptor PF01094.26 001279478.1_37527001_3 - 4.3e-54 183.8 0.0 6.9e-54 183.1 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan-Glu_bd PF10613.7 001279478.1_37527001_3 - 5.5e-42 142.4 0.0 1e-41 141.6 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001279478.1_37527001_3 - 3e-23 82.3 0.0 6.5e-23 81.2 0.0 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.4 001279478.1_37527001_3 - 0.0007 19.3 0.0 0.0029 17.2 0.0 1.9 2 0 0 2 2 2 1 Periplasmic binding protein TGF_beta PF00019.18 205211.1_23523001_2 - 1.1e-33 116.1 0.1 2e-33 115.3 0.1 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 205211.1_23523001_2 - 2.5e-06 27.3 0.0 5.4e-06 26.2 0.0 1.5 1 1 0 1 1 1 1 TGF-beta propeptide Glyco_transf_29 PF00777.16 204511.1_23523001_2 - 1.1e-35 123.2 0.0 1.9e-35 122.4 0.0 1.3 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) UDPGT PF00201.16 033479.1_16122120_1 - 4.3e-46 157.6 0.0 5.2e-46 157.3 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_4 PF13439.4 033479.1_16122120_1 - 0.026 14.4 0.0 0.21 11.5 0.0 1.9 1 1 0 1 1 1 0 Glycosyltransferase Family 4 UDPGT PF00201.16 033480.1_16123120_1 - 8e-05 21.5 0.0 0.00012 20.9 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase UDPGT PF00201.16 033480.1_16123120_2 - 6.7e-13 48.1 0.1 8.7e-13 47.7 0.1 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase UDPGT PF00201.16 033480.1_16123120_3 - 1.5e-08 33.8 0.0 1.8e-08 33.5 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Histone_H2A_C PF16211.3 001079475.1_23521001_1 - 1.2e-20 72.8 1.1 2e-20 72.1 1.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.22 001079475.1_23521001_1 - 5e-17 62.4 0.0 6.3e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 001079475.1_23521001_1 - 3.1e-05 24.0 0.0 4.2e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Myosin_head PF00063.19 001113709.1_23529001_1 - 1.8e-287 955.0 3.4 1.8e-287 955.0 3.4 3.3 5 0 0 5 5 5 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 001113709.1_23529001_1 - 3.7e-162 541.5 270.3 4.7e-162 541.2 270.3 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 001113709.1_23529001_1 - 3.2e-14 52.3 1.5 9.8e-14 50.8 1.5 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 001113709.1_23529001_1 - 2e-07 30.6 74.6 0.0021 17.4 2.9 9.1 1 1 11 13 13 13 10 Reovirus sigma C capsid protein DUF1664 PF07889.10 001113709.1_23529001_1 - 0.0042 16.9 9.3 0.0042 16.9 9.3 14.2 4 3 10 15 15 15 7 Protein of unknown function (DUF1664) AAA_22 PF13401.4 001113709.1_23529001_1 - 0.089 12.9 0.0 0.089 12.9 0.0 5.4 3 2 1 5 5 5 0 AAA domain AAA_16 PF13191.4 001113709.1_23529001_1 - 0.43 10.8 0.0 0.43 10.8 0.0 5.9 2 1 0 2 2 2 0 AAA ATPase domain TNF PF00229.16 001289423.1_37522001_1 - 1.3e-12 47.7 0.0 2e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family EGF PF00008.25 204973.2_23526001_1 - 2e-38 130.2 158.4 1.7e-08 34.5 6.0 10.8 10 1 0 10 10 10 7 EGF-like domain MNNL PF07657.11 204973.2_23526001_1 - 9.9e-26 89.5 1.0 9.9e-26 89.5 1.0 4.6 5 1 0 5 5 5 1 N terminus of Notch ligand hEGF PF12661.5 204973.2_23526001_1 - 3.7e-24 84.3 143.6 1.1e-06 28.9 10.9 11.8 12 0 0 12 12 12 6 Human growth factor-like EGF DSL PF01414.17 204973.2_23526001_1 - 7.2e-24 83.6 8.1 7.2e-24 83.6 8.1 7.7 4 2 3 7 7 7 2 Delta serrate ligand EGF_CA PF07645.13 204973.2_23526001_1 - 8.8e-05 22.5 27.6 0.00013 21.9 9.6 10.7 5 2 5 10 10 10 5 Calcium-binding EGF domain EGF_3 PF12947.5 204973.2_23526001_1 - 0.00023 21.1 21.4 0.00045 20.2 8.9 10.4 8 3 2 10 10 10 4 EGF domain EGF_2 PF07974.11 204973.2_23526001_1 - 0.0085 16.3 11.5 0.0085 16.3 11.5 12.8 12 0 0 12 12 12 6 EGF-like domain ECSCR PF15820.3 204973.2_23526001_1 - 0.044 13.5 0.2 0.1 12.3 0.2 1.6 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator SelK_SelG PF10961.6 001025441.2_23522001_2 - 3e-28 98.1 0.7 4.7e-28 97.5 0.7 1.3 1 0 0 1 1 1 1 Selenoprotein SelK_SelG ODC_AZ PF02100.15 001291895.1_02227001_1 - 3.3e-20 72.1 0.0 5.6e-20 71.3 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001291998.1_02222001_1 - 3.8e-13 49.3 0.0 5.8e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001142862.3_23523001_2 - 1.2e-20 73.5 0.0 2.8e-20 72.3 0.0 1.5 2 0 0 2 2 2 1 Ornithine decarboxylase antizyme Calreticulin PF00262.16 001348545.1_23524001_1 - 2.6e-83 279.8 9.5 5.3e-61 206.4 0.2 2.1 1 1 1 2 2 2 2 Calreticulin family Exo_endo_phos PF03372.21 200869.1_16127001_2 - 0.00024 21.2 0.1 0.00038 20.6 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family FTO_NTD PF12933.5 001185147.1_23526001_3 - 4.2e-119 396.9 0.0 6.2e-119 396.3 0.0 1.2 1 0 0 1 1 1 1 FTO catalytic domain FTO_CTD PF12934.5 001185147.1_23526001_3 - 5.2e-68 227.9 10.0 7.7e-68 227.3 10.0 1.3 1 0 0 1 1 1 1 FTO C-terminal domain Fibrinogen_C PF00147.16 001277819.1_23523001_1 - 2.5e-78 262.7 15.6 3.4e-78 262.3 15.6 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Forkhead PF00250.16 001012955.1_23527001_1 - 2.5e-29 101.3 0.4 4.9e-29 100.4 0.4 1.5 1 0 0 1 1 1 1 Forkhead domain G-gamma PF00631.20 001267819.1_23522001_2 - 1.1e-10 41.2 0.2 2.2e-10 40.2 0.2 1.5 1 0 0 1 1 1 1 GGL domain BIR PF00653.19 204588.2_23524001_1 - 1.5e-62 208.1 7.2 1.9e-21 76.4 0.2 3.7 3 0 0 3 3 3 3 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.4 204588.2_23524001_1 - 2.6e-11 43.1 12.9 2.6e-11 43.1 12.9 3.5 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 204588.2_23524001_1 - 3.2e-06 26.7 12.2 3.2e-06 26.7 12.2 2.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 SinI PF08671.8 204588.2_23524001_1 - 0.048 13.3 0.5 0.22 11.2 0.0 2.2 2 0 0 2 2 2 0 Anti-repressor SinI RRM_1 PF00076.20 001080861.1_23529001_1 - 2.7e-12 46.2 0.0 4.3e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF-4B PF06273.9 001080861.1_23529001_1 - 0.083 11.8 0.9 0.13 11.2 0.9 1.2 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B ALAD PF00490.19 001291406.2_23523001_1 - 6.3e-127 423.0 0.0 7.4e-127 422.7 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase TGF_beta PF00019.18 206988.2_23524001_3 - 4.4e-26 91.7 0.3 9.6e-26 90.6 0.3 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 206988.2_23524001_3 - 0.028 14.0 0.0 0.052 13.1 0.0 1.4 1 0 0 1 1 1 0 TGF-beta propeptide CAMSAP_CKK PF08683.9 206988.2_23524001_3 - 0.041 13.9 0.0 0.074 13.1 0.0 1.3 1 0 0 1 1 1 0 Microtubule-binding calmodulin-regulated spectrin-associated zf-H2C2_2 PF13465.4 001349738.1_23525001_2 - 1.1e-49 164.5 95.6 9e-09 35.3 0.6 13.7 14 0 0 14 14 14 10 Zinc-finger double domain zf-C2H2 PF00096.24 001349738.1_23525001_2 - 1.9e-34 116.0 101.8 4.6e-06 26.7 0.7 13.1 13 0 0 13 13 12 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001349738.1_23525001_2 - 1.5e-31 106.1 101.5 0.00069 20.1 0.5 13.5 13 0 0 13 13 13 12 C2H2-type zinc finger zf-met PF12874.5 001349738.1_23525001_2 - 6.1e-16 58.1 78.4 0.0053 17.0 0.8 11.0 12 0 0 12 12 11 9 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001349738.1_23525001_2 - 1.2e-13 50.9 58.9 0.085 13.1 0.0 12.2 12 0 0 12 12 12 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001349738.1_23525001_2 - 2.8e-09 36.6 86.1 6.9e-08 32.1 0.9 12.1 12 1 0 12 12 12 6 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001349738.1_23525001_2 - 9.6e-05 21.9 3.6 0.00086 18.9 0.5 9.3 11 0 0 11 11 9 4 zinc-finger C2H2-type BolA PF01722.16 001349738.1_23525001_2 - 0.00084 19.4 8.1 7.7 6.7 0.4 5.6 3 2 4 7 7 7 2 BolA-like protein Complex1_49kDa PF00346.17 001349738.1_23525001_2 - 0.011 14.7 0.4 1.8 7.5 0.0 2.8 3 0 0 3 3 3 0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Cwf_Cwc_15 PF04889.10 001349738.1_23525001_2 - 1.4 8.5 12.7 2.3 7.8 12.7 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.10 001349738.1_23525001_2 - 8.8 4.3 20.9 12 3.8 20.9 1.1 1 0 0 1 1 1 0 Nop14-like family zf-H2C2_2 PF13465.4 001349739.1_23528001_1 - 2.7e-49 163.3 72.4 2.7e-08 33.8 1.1 11.4 11 0 0 11 11 11 8 Zinc-finger double domain zf-C2H2 PF00096.24 001349739.1_23528001_1 - 4.8e-32 108.5 89.4 0.00028 21.0 1.3 10.6 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001349739.1_23528001_1 - 6.7e-23 79.3 97.3 0.00058 20.3 0.9 11.2 12 0 0 12 12 10 10 C2H2-type zinc finger BTB PF00651.29 001349739.1_23528001_1 - 1.1e-21 77.0 1.5 2.5e-21 75.9 1.5 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-met PF12874.5 001349739.1_23528001_1 - 2.2e-07 30.9 69.3 0.039 14.2 0.2 10.3 10 0 0 10 10 10 5 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 001349739.1_23528001_1 - 4.2e-06 26.3 54.6 0.081 12.6 0.2 9.8 9 0 0 9 9 9 6 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 001349739.1_23528001_1 - 1.3e-05 25.2 52.2 0.38 11.0 0.4 10.2 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001349739.1_23528001_1 - 9.3e-05 22.1 74.3 0.015 15.1 1.9 10.3 10 0 0 10 10 10 4 C2H2-type zinc finger zf-C2H2_8 PF15909.3 001349739.1_23528001_1 - 0.003 17.7 42.2 0.0038 17.4 4.1 5.5 1 1 3 5 5 5 2 C2H2-type zinc ribbon BolA PF01722.16 001349739.1_23528001_1 - 0.013 15.6 16.5 0.057 13.6 1.8 4.7 2 2 2 5 5 5 0 BolA-like protein HypA PF01155.17 001349739.1_23528001_1 - 0.24 11.3 33.7 0.62 10.0 3.0 5.1 2 2 1 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.3 001349739.1_23528001_1 - 3.5 8.3 39.0 4 8.1 1.1 6.0 2 2 4 6 6 6 0 zinc-ribbon family DUF3268 PF11672.6 001349739.1_23528001_1 - 3.9 7.7 22.4 1.1 9.5 0.2 4.3 4 0 0 4 4 4 0 zinc-finger-containing domain XPG_N PF00752.15 001034823.1_23527001_1 - 6.8e-34 116.2 0.0 2e-33 114.8 0.0 1.9 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.16 001034823.1_23527001_1 - 7e-25 87.1 0.0 7.3e-24 83.8 0.0 3.0 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.18 001034823.1_23527001_1 - 0.00068 20.1 2.5 0.022 15.2 0.0 3.3 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold CSTF2_hinge PF14327.4 001034823.1_23527001_1 - 0.064 13.6 0.2 0.2 12.0 0.2 1.9 1 0 0 1 1 1 0 Hinge domain of cleavage stimulation factor subunit 2 Abhydrolase_3 PF07859.11 001017677.1_16123001_1 - 2.1e-14 53.7 0.3 1.3e-13 51.2 0.3 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.26 001017677.1_16123001_1 - 0.00032 19.6 0.1 0.0075 15.1 0.0 2.1 2 0 0 2 2 2 1 Carboxylesterase family Lipase_3 PF01764.23 001017677.1_16123001_1 - 0.0023 17.7 0.0 0.0035 17.1 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.6 001017677.1_16123001_1 - 0.0028 16.8 0.0 0.004 16.3 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 FSH1 PF03959.11 001017677.1_16123001_1 - 0.038 13.5 0.0 0.071 12.6 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DUF2974 PF11187.6 001017677.1_16123001_1 - 0.15 11.5 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Ribosomal_L33 PF00471.18 130124.1_16122120_2 - 2.1e-06 27.9 0.6 1.5e-05 25.2 0.1 2.2 2 0 0 2 2 2 1 Ribosomal protein L33 Na_Pi_cotrans PF02690.13 204474.2_23529001_3 - 6.5e-39 133.1 20.0 7.9e-24 84.2 6.5 2.4 2 0 0 2 2 2 2 Na+/Pi-cotransporter MAM PF00629.21 001318981.1_23529001_3 - 1.8e-268 879.4 38.6 1.7e-42 144.9 0.0 9.4 9 0 0 9 9 9 9 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.16 001318981.1_23529001_3 - 3.5e-57 190.2 132.1 6e-09 35.9 1.3 10.5 9 0 0 9 9 9 9 Low-density lipoprotein receptor domain class A RCC1 PF00415.16 001006212.1_23526001_3 - 5.7e-56 186.8 13.4 2.4e-09 37.5 0.1 7.5 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 001006212.1_23526001_3 - 1e-26 92.0 33.7 1.1e-06 28.1 0.4 8.0 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat TF_AP-2 PF03299.12 001135785.1_23523001_1 - 2.4e-85 285.3 0.0 4.2e-85 284.5 0.0 1.4 1 0 0 1 1 1 1 Transcription factor AP-2 DUF367 PF04034.11 001277169.1_23523001_3 - 7.9e-54 180.6 0.0 1.1e-53 180.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF367) RLI PF04068.13 001277169.1_23523001_3 - 3.2e-13 49.1 0.9 7e-13 48.0 0.9 1.6 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI DUF4580 PF15162.4 001277653.1_23522001_1 - 8.8e-85 282.1 2.0 1.1e-84 281.8 2.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4580) DUF4749 PF15936.3 001277653.1_23522001_1 - 0.091 13.8 0.2 0.22 12.6 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4749) DUF563 PF04577.12 001031409.1_23524001_1 - 2.1e-28 99.7 0.4 3.3e-28 99.1 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) RLL PF10036.7 205369.1_23522001_3 - 4.5e-86 288.7 0.6 5.3e-86 288.5 0.6 1.0 1 0 0 1 1 1 1 Putative carnitine deficiency-associated protein Cactin_mid PF10312.7 205369.1_23522001_3 - 0.017 14.7 0.4 0.026 14.1 0.4 1.2 1 0 0 1 1 1 0 Conserved mid region of cactin DUF2465 PF10239.7 205369.1_23522001_3 - 0.035 13.2 0.1 0.3 10.1 0.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2465) LRR_4 PF12799.5 001006544.1_23524001_3 - 5.4e-08 32.8 10.8 0.00019 21.6 3.4 3.5 2 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001006544.1_23524001_3 - 3.8e-06 26.4 0.1 8.3e-06 25.3 0.1 1.5 1 0 0 1 1 1 1 Leucine-rich repeat SART-1 PF03343.11 001006544.1_23524001_3 - 0.00018 20.1 0.1 0.00018 20.1 0.1 1.8 2 0 0 2 2 2 1 SART-1 family LRR_8 PF13855.4 001006544.1_23524001_3 - 0.00073 19.1 4.9 0.022 14.4 3.0 2.8 1 1 1 2 2 2 2 Leucine rich repeat CEP19 PF14933.4 001277440.1_23523001_3 - 3e-53 180.4 2.3 3.9e-53 180.0 2.3 1.1 1 0 0 1 1 1 1 CEP19-like protein Radial_spoke PF04712.10 102410.1_23522120_1 - 8e-05 21.6 0.1 0.00018 20.5 0.0 1.6 1 1 1 2 2 2 1 Radial spokehead-like protein Calponin PF00402.16 001142256.1_23523001_1 - 5.9e-43 144.0 23.9 9.8e-17 60.1 0.8 4.2 3 0 0 3 3 3 3 Calponin family repeat CH PF00307.29 001142256.1_23523001_1 - 1.7e-21 76.3 0.1 2.7e-21 75.6 0.1 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001142256.1_23523001_1 - 0.015 15.0 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 CAMSAP CH domain CD36 PF01130.19 173259.1_16127001_2 - 1.2e-151 505.3 1.5 1.5e-151 505.0 1.5 1.1 1 0 0 1 1 1 1 CD36 family SIT PF15330.4 173259.1_16127001_2 - 0.063 13.6 0.2 0.31 11.3 0.0 2.2 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT DUF4245 PF14030.4 173259.1_16127001_2 - 0.093 12.6 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4245) EphA2_TM PF14575.4 173259.1_16127001_2 - 0.15 12.8 0.0 0.83 10.4 0.0 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.4 173259.1_16127001_2 - 1.3 8.7 4.5 1.8 8.3 3.2 1.7 1 1 0 1 1 1 0 TMEM154 protein family AMPK1_CBM PF16561.3 001039912.1_23525001_3 - 1.6e-34 117.8 0.4 2.5e-34 117.2 0.4 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.13 001039912.1_23525001_3 - 4.1e-27 94.1 1.8 7.2e-27 93.3 1.8 1.4 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM_48 PF02922.16 001039912.1_23525001_3 - 0.031 14.5 0.0 0.06 13.6 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) UCR_UQCRX_QCR9 PF05365.10 001302478.1_16122001_1 - 1e-25 89.3 0.7 1.7e-25 88.6 0.7 1.4 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Orn_Arg_deC_N PF02784.14 001291467.2_02229001_1 - 2.5e-53 181.0 0.0 3.2e-53 180.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001291467.2_02229001_1 - 1.9e-24 85.8 0.0 3.1e-24 85.1 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain UPF0061 PF02696.12 001115017.3_23529001_3 - 2.4e-122 408.9 0.0 3.4e-122 408.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family XPC-binding PF09280.9 001115017.3_23529001_3 - 0.078 12.6 0.3 0.47 10.1 0.4 2.1 2 0 0 2 2 2 0 XPC-binding domain DUF4187 PF13821.4 102417.2_23523120_2 - 1.5e-20 72.5 2.9 1.8e-20 72.3 0.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) MRP-S27 PF10037.7 001017612.1_16123001_1 - 1.7e-08 33.7 0.2 3.3e-08 32.7 0.2 1.4 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S27 PPR_2 PF13041.4 001017612.1_16123001_1 - 0.00012 22.1 0.7 0.00024 21.1 0.1 1.9 2 0 0 2 2 2 1 PPR repeat family CEP63 PF17045.3 001017612.1_16123001_1 - 0.0031 17.3 1.2 0.0053 16.6 1.2 1.3 1 0 0 1 1 1 1 Centrosomal protein of 63 kDa PPR_3 PF13812.4 001017612.1_16123001_1 - 0.079 12.9 0.1 0.33 10.9 0.0 2.1 2 0 0 2 2 2 0 Pentatricopeptide repeat domain PPR PF01535.18 001017612.1_16123001_1 - 0.091 12.9 0.1 0.65 10.3 0.0 2.5 2 0 0 2 2 2 0 PPR repeat Carn_acyltransf PF00755.18 204610.1_23525001_1 - 3.4e-192 640.0 0.0 3.9e-192 639.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Helicase_C_2 PF13307.4 001033058.1_23528001_1 - 7.5e-54 182.3 0.0 2.1e-53 180.9 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.13 001033058.1_23528001_1 - 4.4e-50 169.6 0.1 4.4e-50 169.6 0.1 3.2 4 0 0 4 4 4 1 DEAD_2 DEAD PF00270.27 001033058.1_23528001_1 - 1.3e-05 24.9 0.0 8.3e-05 22.3 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase HBB PF06777.9 001033058.1_23528001_1 - 0.00014 21.4 0.0 0.00035 20.2 0.0 1.6 1 0 0 1 1 1 1 Helical and beta-bridge domain ResIII PF04851.13 001033058.1_23528001_1 - 0.00034 20.5 0.1 0.15 11.9 0.0 3.0 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit F-box_4 PF15966.3 001033058.1_23528001_1 - 0.0047 16.7 1.4 0.73 9.6 0.1 2.8 2 0 0 2 2 2 2 F-box EF-hand_6 PF13405.4 205479.3_23522001_3 - 1.1e-08 34.2 0.0 0.00083 19.0 0.0 3.6 3 1 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.30 205479.3_23522001_3 - 0.00019 20.6 2.6 0.24 10.9 0.0 4.0 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.4 205479.3_23522001_3 - 0.00023 21.3 0.0 0.19 12.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain Ribosom_S30AE_C PF16321.3 205479.3_23522001_3 - 0.025 14.1 0.0 0.045 13.3 0.0 1.4 1 0 0 1 1 1 0 Sigma 54 modulation/S30EA ribosomal protein C terminus EF-hand_7 PF13499.4 205479.3_23522001_3 - 0.042 14.2 0.0 0.24 11.8 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.4 205159.1_23522001_3 - 4e-09 35.6 0.0 0.01 15.6 0.0 3.8 4 1 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.30 205159.1_23522001_3 - 2.7e-06 26.4 0.8 0.021 14.2 0.0 4.3 4 0 0 4 4 4 1 EF hand EF-hand_7 PF13499.4 205159.1_23522001_3 - 0.00082 19.7 0.1 0.0047 17.2 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.4 205159.1_23522001_3 - 0.0079 15.8 0.5 4 7.2 0.0 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.4 205159.1_23522001_3 - 0.022 14.9 0.0 3.1 8.1 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain DUF2267 PF10025.7 205159.1_23522001_3 - 0.043 14.0 0.2 0.14 12.3 0.1 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) DEC-1_N PF04625.11 205159.1_23522001_3 - 0.12 11.3 2.2 0.14 11.0 2.2 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Ins134_P3_kin PF05770.9 001012588.1_23529001_3 - 2.3e-132 440.8 0.1 3e-132 440.4 0.1 1.1 1 0 0 1 1 1 1 Inositol 1, 3, 4-trisphosphate 5/6-kinase PTPlike_phytase PF14566.4 198811.1_16127001_1 - 4.3e-79 264.0 0.2 2.8e-40 137.9 0.0 2.6 2 0 0 2 2 2 2 Inositol hexakisphosphate YjcZ PF13990.4 198811.1_16127001_1 - 0.0075 15.5 0.0 0.016 14.5 0.0 1.5 1 0 0 1 1 1 1 YjcZ-like protein Y_phosphatase3 PF13350.4 198811.1_16127001_1 - 0.009 15.9 0.0 0.058 13.2 0.0 2.2 2 0 0 2 2 2 1 Tyrosine phosphatase family Aminotran_1_2 PF00155.19 205523.1_23523001_2 - 4e-89 299.2 0.0 4.6e-89 299.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II BTK PF00779.17 205523.1_23523001_3 - 1 9.1 8.0 2 8.1 0.9 2.8 2 0 0 2 2 2 0 BTK motif COPIIcoated_ERV PF07970.10 200407.1_16124001_3 - 2.9e-50 171.0 0.4 4.5e-50 170.4 0.4 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.4 200407.1_16124001_3 - 8.1e-24 83.7 0.1 1.6e-23 82.7 0.1 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Med29 PF11568.6 173271.1_16122001_2 - 1.6e-51 174.0 0.4 1.6e-51 174.0 0.4 1.5 1 1 1 2 2 2 1 Mediator complex subunit 29 Metalloenzyme PF01676.16 173271.1_16122001_2 - 0.14 11.4 0.0 0.17 11.1 0.0 1.2 1 1 0 1 1 1 0 Metalloenzyme superfamily EF-hand_7 PF13499.4 200131.1_16124001_2 - 1.6e-08 34.8 5.8 1.9e-05 24.9 0.0 4.4 4 1 1 5 5 5 3 EF-hand domain pair EF-hand_6 PF13405.4 200131.1_16124001_2 - 5.1e-05 22.8 3.8 2 8.5 0.0 5.0 5 0 0 5 5 5 2 EF-hand domain EF-hand_1 PF00036.30 200131.1_16124001_2 - 0.00017 20.7 0.6 0.33 10.5 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.4 200131.1_16124001_2 - 0.011 15.4 0.0 1.3 8.8 0.0 2.9 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.4 200131.1_16124001_2 - 0.037 13.4 0.2 0.21 11.0 0.0 2.4 2 0 0 2 2 2 0 EF hand DUF61 PF01886.14 200131.1_16124001_2 - 0.083 12.8 0.1 0.31 11.0 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function DUF61 ABC_membrane PF00664.21 204894.1_23528001_3 - 5e-158 524.8 31.2 5.9e-88 294.9 10.5 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 204894.1_23528001_3 - 1.8e-75 251.8 0.3 4.6e-37 127.4 0.1 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 204894.1_23528001_3 - 4.4e-16 58.8 0.5 6e-07 29.0 0.2 3.4 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 204894.1_23528001_3 - 2.5e-09 37.6 0.7 0.0035 17.6 0.2 3.0 2 1 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.7 204894.1_23528001_3 - 2.4e-08 33.1 1.2 0.0022 16.7 0.1 3.1 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_22 PF13401.4 204894.1_23528001_3 - 1.4e-07 31.7 1.0 0.042 14.0 0.1 3.4 2 2 0 2 2 2 2 AAA domain Zeta_toxin PF06414.10 204894.1_23528001_3 - 3.5e-07 29.6 1.6 0.0021 17.2 0.0 3.8 4 0 0 4 4 4 1 Zeta toxin DUF258 PF03193.14 204894.1_23528001_3 - 3.1e-06 27.1 0.0 0.04 13.7 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function, DUF258 G-alpha PF00503.18 204894.1_23528001_3 - 5.4e-06 25.7 0.1 0.051 12.6 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit AAA_5 PF07728.12 204894.1_23528001_3 - 9e-06 25.6 0.3 0.24 11.3 0.1 3.6 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_29 PF13555.4 204894.1_23528001_3 - 1.3e-05 24.6 0.6 0.25 11.0 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.4 204894.1_23528001_3 - 4.6e-05 23.1 2.6 0.23 11.0 0.4 3.4 2 2 0 2 2 2 2 AAA domain AAA PF00004.27 204894.1_23528001_3 - 7.4e-05 23.0 6.9 0.33 11.3 0.6 4.9 3 2 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.4 204894.1_23528001_3 - 0.00011 21.8 6.8 0.051 13.1 0.1 3.2 3 1 0 3 3 2 2 AAA ATPase domain Rad17 PF03215.13 204894.1_23528001_3 - 0.00016 20.6 0.1 0.2 10.4 0.0 2.3 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_28 PF13521.4 204894.1_23528001_3 - 0.0002 21.5 0.8 1.1 9.3 0.1 4.1 4 1 1 5 5 5 1 AAA domain DUF87 PF01935.15 204894.1_23528001_3 - 0.00026 21.0 2.7 0.36 10.7 0.0 3.6 4 0 0 4 4 4 2 Domain of unknown function DUF87 SbcCD_C PF13558.4 204894.1_23528001_3 - 0.00027 21.0 3.5 1.4 9.1 0.2 4.1 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit tRNA_lig_kinase PF08303.9 204894.1_23528001_3 - 0.00059 19.8 0.0 0.24 11.4 0.0 2.9 2 0 0 2 2 2 1 tRNA ligase kinase domain PRK PF00485.16 204894.1_23528001_3 - 0.0011 18.7 0.1 1.1 8.8 0.0 2.6 2 1 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family AAA_21 PF13304.4 204894.1_23528001_3 - 0.0014 18.3 0.2 2.2 7.8 0.0 3.8 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system ATP-synt_ab PF00006.23 204894.1_23528001_3 - 0.0019 17.7 0.5 2.3 7.7 0.3 2.9 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_14 PF13173.4 204894.1_23528001_3 - 0.0021 18.0 0.1 2 8.3 0.0 3.8 3 1 1 4 4 4 1 AAA domain DUF815 PF05673.11 204894.1_23528001_3 - 0.0029 16.7 0.0 0.73 8.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.20 204894.1_23528001_3 - 0.0041 17.4 0.2 5.5 7.3 0.1 3.1 2 1 0 2 2 2 0 RNA helicase AAA_24 PF13479.4 204894.1_23528001_3 - 0.0062 16.2 0.0 2.2 7.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.15 204894.1_23528001_3 - 0.0076 15.9 2.3 8.4 6.0 0.0 4.1 4 0 0 4 4 4 0 IstB-like ATP binding protein DUF2207 PF09972.7 204894.1_23528001_3 - 0.014 14.1 0.0 0.014 14.1 0.0 3.3 4 0 0 4 4 4 0 Predicted membrane protein (DUF2207) AAA_18 PF13238.4 204894.1_23528001_3 - 0.023 15.1 0.0 3.2 8.1 0.0 3.0 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.4 204894.1_23528001_3 - 0.03 14.3 0.0 3.2 7.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain NACHT PF05729.10 204894.1_23528001_3 - 0.034 13.9 0.5 8.6 6.1 0.1 2.5 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.4 204894.1_23528001_3 - 0.04 13.3 0.4 1.9 7.9 0.0 2.9 3 0 0 3 3 2 0 AAA domain RepB-RCR_reg PF10723.7 204894.1_23528001_3 - 0.093 12.6 0.0 19 5.2 0.0 2.8 2 0 0 2 2 2 0 Replication regulatory protein RepB AAA_19 PF13245.4 204894.1_23528001_3 - 0.096 12.9 0.8 5.8 7.1 0.3 2.9 3 1 0 3 3 2 0 AAA domain Mg_chelatase PF01078.19 204894.1_23528001_3 - 0.099 11.9 0.0 3.1 7.0 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.20 204894.1_23528001_3 - 0.1 11.4 0.5 11 4.8 0.0 2.8 3 0 0 3 3 3 0 NB-ARC domain AAA_17 PF13207.4 204894.1_23528001_3 - 0.17 12.2 1.3 25 5.2 0.1 3.4 4 0 0 4 4 3 0 AAA domain RP-C_C PF11800.6 204894.1_23528001_3 - 1.3 8.9 3.9 2.2 8.2 0.3 2.6 2 0 0 2 2 2 0 Replication protein C C-terminal region DUF829 PF05705.12 001002637.1_16123001_1 - 2.7e-66 223.8 0.0 3.5e-66 223.4 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) zf-C4_Topoisom PF01396.17 001002637.1_16123001_1 - 0.036 13.7 0.2 0.08 12.6 0.2 1.6 1 0 0 1 1 1 0 Topoisomerase DNA binding C4 zinc finger HlyIII PF03006.18 001007854.1_23524001_1 - 1.5e-71 240.6 21.5 1.9e-71 240.2 21.5 1.1 1 0 0 1 1 1 1 Haemolysin-III related PDCD9 PF07147.10 001081505.1_23523001_1 - 5.2e-13 48.9 0.2 3.4e-09 36.3 0.1 2.2 2 0 0 2 2 2 2 Mitochondrial 28S ribosomal protein S30 (PDCD9) Ribophorin_II PF05817.12 001006288.1_23525001_2 - 2.2e-230 766.4 8.1 2.7e-230 766.1 8.1 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II IBN_N PF03810.17 001012942.1_23528001_3 - 3.1e-13 49.3 0.1 3.1e-13 49.3 0.1 2.9 3 0 0 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.10 001012942.1_23528001_3 - 0.007 16.3 0.6 0.007 16.3 0.6 3.6 4 0 0 4 4 4 1 Exportin 1-like protein Rep_fac_C PF08542.9 001012942.1_23528001_3 - 1.1 9.5 3.4 12 6.2 0.0 4.1 4 0 0 4 4 4 0 Replication factor C C-terminal domain CRM1_C PF08767.9 001012947.2_23529001_3 - 2.6e-05 23.4 0.9 2.6e-05 23.4 0.9 2.2 2 0 0 2 2 2 1 CRM1 C terminal 7tm_1 PF00001.19 001128665.1_23523001_2 - 1.6e-53 181.5 16.8 2.2e-53 181.1 16.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001128665.1_23523001_2 - 8.4e-14 51.5 13.6 1.4e-12 47.4 13.6 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.7 001128665.1_23523001_2 - 1.6e-07 30.9 15.7 1.6e-07 30.9 14.8 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001128665.1_23523001_2 - 2.1e-07 30.9 4.8 2.1e-07 30.9 4.8 2.1 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001128665.1_23523001_2 - 0.0014 17.9 11.7 0.0014 17.9 11.7 2.3 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Flavi_capsid PF01003.17 001128665.1_23523001_2 - 0.079 12.6 0.1 0.2 11.3 0.1 1.7 1 0 0 1 1 1 0 Flavivirus capsid protein C Sigma_reg_N PF13800.4 001128665.1_23523001_2 - 0.21 11.8 0.2 0.21 11.8 0.2 3.1 4 0 0 4 4 4 0 Sigma factor regulator N-terminal 7tm_1 PF00001.19 001319014.1_23523001_2 - 4e-21 75.3 11.7 4.5e-16 58.7 2.5 2.6 2 1 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001319014.1_23523001_2 - 0.0064 15.7 2.8 0.015 14.5 2.8 1.6 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.19 001318430.1_23523001_2 - 2.1e-21 76.2 12.3 5.3e-15 55.2 3.9 2.5 2 1 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001318430.1_23523001_2 - 0.0038 16.5 8.9 0.017 14.4 3.8 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 001318430.1_23523001_2 - 0.014 14.6 5.1 0.026 13.7 5.1 1.5 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx COPI_C PF06957.9 001031405.2_23529001_3 - 2.7e-187 622.4 0.0 3.5e-187 622.0 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus Coatomer_WDAD PF04053.12 001031405.2_23529001_3 - 3e-144 481.3 1.1 4.9e-144 480.6 1.1 1.3 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.30 001031405.2_23529001_3 - 1.5e-38 130.0 23.3 1.7e-07 31.7 0.2 8.1 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001031405.2_23529001_3 - 8.7e-09 35.4 1.6 4.2e-05 23.6 0.0 4.8 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain TPR_14 PF13428.4 001031405.2_23529001_3 - 0.0063 17.1 0.4 1.9 9.4 0.0 4.0 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.15 001031405.2_23529001_3 - 0.17 11.9 0.1 27 5.1 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Nup160 PF11715.6 001031405.2_23529001_3 - 0.22 10.0 5.2 1.9 6.8 0.0 3.2 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Ocnus PF05005.13 001277693.1_23522001_3 - 6.2e-24 84.1 0.1 8.7e-24 83.6 0.1 1.2 1 0 0 1 1 1 1 Janus/Ocnus family (Ocnus) bZIP_2 PF07716.13 001031459.1_23522001_1 - 3.8e-16 58.8 16.1 6.2e-16 58.1 16.1 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.19 001031459.1_23522001_1 - 1.3e-05 25.1 8.9 2.1e-05 24.4 8.9 1.3 1 0 0 1 1 1 1 bZIP transcription factor Lipoprotein_20 PF13942.4 001031459.1_23522001_1 - 0.0089 15.8 4.7 0.015 15.1 4.7 1.3 1 0 0 1 1 1 1 YfhG lipoprotein Taxilin PF09728.7 001031459.1_23522001_1 - 0.01 15.0 5.2 0.017 14.3 5.2 1.4 1 0 0 1 1 1 0 Myosin-like coiled-coil protein DUF2514 PF10721.7 001031459.1_23522001_1 - 0.013 15.4 1.1 0.22 11.4 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) Nup54 PF13874.4 001031459.1_23522001_1 - 0.015 15.2 5.0 0.03 14.3 5.0 1.4 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 TolA_bind_tri PF16331.3 001031459.1_23522001_1 - 0.028 14.3 2.1 0.06 13.3 2.1 1.5 1 0 0 1 1 1 0 TolA binding protein trimerisation bZIP_Maf PF03131.15 001031459.1_23522001_1 - 0.038 14.4 7.8 0.069 13.5 7.8 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor CENP-Q PF13094.4 001031459.1_23522001_1 - 0.047 13.7 3.2 0.1 12.6 3.2 1.5 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit SBE2 PF17076.3 001031459.1_23522001_1 - 0.097 10.7 0.9 0.13 10.4 0.9 1.0 1 0 0 1 1 1 0 SBE2, cell-wall formation DivIC PF04977.13 001031459.1_23522001_1 - 0.11 12.2 2.4 0.22 11.2 2.4 1.5 1 0 0 1 1 1 0 Septum formation initiator WD40_alt PF14077.4 001031459.1_23522001_1 - 0.16 11.7 0.4 0.36 10.6 0.4 1.5 1 0 0 1 1 1 0 Alternative WD40 repeat motif IncA PF04156.12 001031459.1_23522001_1 - 0.23 11.1 1.4 0.49 10.0 1.4 1.5 1 0 0 1 1 1 0 IncA protein IBB PF01749.18 001031459.1_23522001_1 - 1.1 9.5 11.1 2.2 8.6 11.1 1.4 1 0 0 1 1 1 0 Importin beta binding domain CENP-H PF05837.10 001031459.1_23522001_1 - 1.2 9.5 6.3 0.37 11.1 3.6 1.5 2 0 0 2 2 1 0 Centromere protein H (CENP-H) Ion_trans PF00520.29 204692.1_23527001_3 - 1e-14 54.2 17.4 1.8e-14 53.5 17.4 1.3 1 0 0 1 1 1 1 Ion transport protein Ank_2 PF12796.5 204692.1_23527001_3 - 5.3e-14 52.4 0.2 1.2e-05 25.7 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 204692.1_23527001_3 - 3.2e-10 39.9 0.1 0.00054 20.2 0.0 4.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.4 204692.1_23527001_3 - 5.3e-10 38.5 0.2 0.0025 18.0 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.4 204692.1_23527001_3 - 8.4e-09 35.4 0.4 0.061 13.6 0.0 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 204692.1_23527001_3 - 7.2e-08 32.7 0.3 0.014 15.8 0.2 3.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) DUF788 PF05620.9 204692.1_23527001_3 - 3.3 7.5 6.0 11 5.7 6.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF788) PDEase_I PF00233.17 001031291.2_23527001_3 - 1.5e-93 312.7 4.8 1.5e-93 312.7 4.8 1.8 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase Prominin PF05478.9 001291651.1_23529001_3 - 5.5e-256 851.3 11.1 6.7e-256 851.1 11.1 1.0 1 0 0 1 1 1 1 Prominin Ribonuc_L-PSP PF01042.19 001291651.1_23529001_3 - 0.078 12.9 0.0 0.24 11.3 0.0 1.8 1 0 0 1 1 1 0 Endoribonuclease L-PSP DUF1218 PF06749.10 001291651.1_23529001_3 - 0.35 11.3 11.7 2.6 8.5 2.2 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) ALIX_LYPXL_bnd PF13949.4 001291651.1_23529001_3 - 0.4 9.8 2.2 0.28 10.3 0.3 1.6 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV Lectin_C PF00059.19 001318433.1_23528001_1 - 1.5e-158 517.8 46.4 2e-21 76.6 0.2 8.2 8 0 0 8 8 8 8 Lectin C-type domain UL45 PF05473.10 001318433.1_23528001_1 - 4.5e-16 59.0 10.4 0.0012 18.4 0.1 7.2 4 2 3 7 7 7 5 UL45 protein, carbohydrate-binding C-type lectin-like Xlink PF00193.15 001318433.1_23528001_1 - 2.5e-09 37.3 14.2 0.45 10.8 0.1 8.4 7 2 0 7 7 7 4 Extracellular link domain Chordopox_A33R PF05966.10 001318433.1_23528001_1 - 4.6e-09 35.7 9.7 0.0082 15.3 0.2 6.5 7 0 0 7 7 7 3 Chordopoxvirus A33R protein Intimin_C PF07979.9 001318433.1_23528001_1 - 0.00021 21.5 5.6 27 5.1 0.1 7.6 8 1 1 9 9 9 0 Intimin C-type lectin domain DUF333 PF03891.13 001318433.1_23528001_1 - 0.029 14.4 0.5 39 4.4 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF333) Adeno_E3_CR1 PF02440.13 001318433.1_23528001_1 - 0.04 13.6 0.7 0.4 10.4 0.1 3.1 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 DUF4366 PF14283.4 001318433.1_23528001_1 - 0.057 12.8 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) SOAR PF16533.3 001030838.1_23526001_2 - 1.5e-43 146.8 3.0 1.5e-43 146.8 3.0 2.8 2 0 0 2 2 2 1 STIM1 Orai1-activating region SAM_2 PF07647.15 001030838.1_23526001_2 - 4.4e-08 33.0 0.3 1.3e-07 31.4 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001030838.1_23526001_2 - 2.3e-05 24.6 0.1 7.2e-05 23.0 0.1 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ste50p-SAM PF09235.8 001030838.1_23526001_2 - 0.12 12.5 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Ste50p, sterile alpha motif AAA_23 PF13476.4 001030838.1_23526001_2 - 0.13 12.6 11.3 0.65 10.3 5.1 3.2 2 1 0 2 2 2 0 AAA domain DUF4446 PF14584.4 001030838.1_23526001_2 - 0.21 11.4 2.5 0.22 11.3 0.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) APG6 PF04111.10 001030838.1_23526001_2 - 6.5 5.9 19.7 11 5.2 19.7 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Bromodomain PF00439.23 001006148.1_23527001_1 - 4.7e-21 74.5 0.1 1.3e-20 73.1 0.1 1.8 1 0 0 1 1 1 1 Bromodomain BBP1_C PF15272.4 001006148.1_23527001_1 - 0.032 13.9 2.3 0.086 12.5 2.3 1.7 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal DUF2209 PF09974.7 001006148.1_23527001_1 - 0.18 12.0 2.9 0.65 10.2 2.9 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) TSC22 PF01166.16 001006148.1_23527001_1 - 0.25 11.6 2.3 0.62 10.3 2.3 1.7 1 0 0 1 1 1 0 TSC-22/dip/bun family DUF106 PF01956.14 001006148.1_23527001_1 - 1.2 8.7 3.3 3.6 7.2 3.3 1.8 1 0 0 1 1 1 0 Integral membrane protein DUF106 CFTR_R PF14396.4 001105666.1_23529001_1 - 1.5e-102 341.5 5.1 1.5e-102 341.5 5.1 1.6 2 0 0 2 2 2 1 Cystic fibrosis TM conductance regulator (CFTR), regulator domain ABC_membrane PF00664.21 001105666.1_23529001_1 - 2.3e-95 319.2 42.9 2.9e-51 174.6 20.8 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001105666.1_23529001_1 - 2.5e-55 186.6 0.0 3.1e-31 108.6 0.0 2.9 3 0 0 3 3 2 2 ABC transporter T2SSE PF00437.18 001105666.1_23529001_1 - 3.3e-07 29.5 0.1 0.022 13.7 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_21 PF13304.4 001105666.1_23529001_1 - 7.5e-07 29.1 0.9 0.29 10.8 0.0 3.7 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001105666.1_23529001_1 - 2.4e-06 27.0 1.8 0.0019 17.7 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.14 001105666.1_23529001_1 - 3.3e-05 23.7 0.4 0.2 11.4 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function, DUF258 SMC_N PF02463.17 001105666.1_23529001_1 - 3.8e-05 23.1 0.0 0.76 9.0 0.0 3.6 2 2 1 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 001105666.1_23529001_1 - 4.9e-05 23.6 0.0 0.33 11.2 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain NACHT PF05729.10 001105666.1_23529001_1 - 0.00058 19.7 0.4 0.87 9.4 0.0 2.8 2 0 0 2 2 2 2 NACHT domain DUF87 PF01935.15 001105666.1_23529001_1 - 0.00064 19.7 1.5 0.82 9.5 0.2 2.7 2 0 0 2 2 2 2 Domain of unknown function DUF87 AAA_23 PF13476.4 001105666.1_23529001_1 - 0.0021 18.5 8.4 0.67 10.3 0.1 3.7 3 0 0 3 3 3 2 AAA domain NTPase_1 PF03266.13 001105666.1_23529001_1 - 0.0034 17.2 0.4 0.48 10.2 0.0 3.1 3 0 0 3 3 3 1 NTPase NB-ARC PF00931.20 001105666.1_23529001_1 - 0.014 14.3 0.5 0.5 9.2 0.1 2.5 2 0 0 2 2 2 0 NB-ARC domain AAA_22 PF13401.4 001105666.1_23529001_1 - 0.028 14.6 1.1 13 5.9 0.0 3.0 3 0 0 3 3 2 0 AAA domain ArgK PF03308.14 001105666.1_23529001_1 - 0.038 12.8 0.5 0.24 10.2 0.2 2.2 3 0 0 3 3 3 0 ArgK protein AAA_30 PF13604.4 001105666.1_23529001_1 - 0.039 13.5 0.0 1.5 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.4 001105666.1_23529001_1 - 0.041 14.1 0.1 9.3 6.4 0.0 2.9 3 1 0 3 3 2 0 AAA domain MMR_HSR1 PF01926.21 001105666.1_23529001_1 - 0.045 13.7 0.3 2.1 8.3 0.0 3.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase Zeta_toxin PF06414.10 001105666.1_23529001_1 - 0.048 12.8 0.2 2.2 7.4 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin FtsK_SpoIIIE PF01580.16 001105666.1_23529001_1 - 0.067 12.4 0.3 12 5.0 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.17 001105666.1_23529001_1 - 0.11 11.9 1.8 4.5 6.7 0.2 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.12 001105666.1_23529001_1 - 0.12 12.1 1.7 16 5.3 0.1 3.2 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B DEAD PF00270.27 001105666.1_23529001_1 - 0.14 11.8 0.3 11 5.5 0.0 2.8 2 1 0 2 2 2 0 DEAD/DEAH box helicase TsaE PF02367.15 001105666.1_23529001_1 - 0.15 11.9 0.3 25 4.8 0.1 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TrwB_AAD_bind PF10412.7 001105666.1_23529001_1 - 0.19 10.5 1.2 4.9 5.8 0.1 2.8 2 1 1 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain Prominin PF05478.9 001291653.1_23529001_3 - 5.3e-256 851.4 11.1 6.4e-256 851.1 11.1 1.0 1 0 0 1 1 1 1 Prominin Ribonuc_L-PSP PF01042.19 001291653.1_23529001_3 - 0.076 12.9 0.0 0.24 11.3 0.0 1.8 1 0 0 1 1 1 0 Endoribonuclease L-PSP DUF1218 PF06749.10 001291653.1_23529001_3 - 0.33 11.3 11.7 2.6 8.5 2.2 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) ALIX_LYPXL_bnd PF13949.4 001291653.1_23529001_3 - 0.39 9.9 2.2 0.27 10.4 0.3 1.6 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV Forkhead PF00250.16 001083359.1_23526001_3 - 3e-32 110.6 0.1 5.4e-32 109.8 0.1 1.4 1 0 0 1 1 1 1 Forkhead domain Ribosomal_L30_N PF08079.10 001083359.1_23526001_3 - 0.099 12.8 0.1 0.18 11.9 0.1 1.3 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain Serpin PF00079.18 001277493.1_23523001_2 - 3.3e-118 395.1 8.7 3.9e-118 394.9 8.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Xpo1 PF08389.10 194374.1_16129001_2 - 1.8e-23 83.1 10.1 4.1e-20 72.2 0.0 6.3 5 1 0 6 6 6 2 Exportin 1-like protein IBN_N PF03810.17 194374.1_16129001_2 - 3.5e-07 29.9 0.0 1.3e-06 28.0 0.0 2.1 1 0 0 1 1 1 1 Importin-beta N-terminal domain Phage_tail_APC PF16778.3 194374.1_16129001_2 - 0.15 11.9 1.4 0.64 9.8 1.0 2.3 2 0 0 2 2 2 0 Phage tail assembly chaperone protein EF-hand_7 PF13499.4 001114410.1_16126001_3 - 5e-26 90.8 2.7 1.9e-17 63.3 0.0 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.30 001114410.1_16126001_3 - 3.7e-23 79.2 4.1 1.7e-06 27.0 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.4 001114410.1_16126001_3 - 1.3e-20 71.7 3.5 1.2e-06 27.6 0.1 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 001114410.1_16126001_3 - 2.7e-20 70.4 0.9 1.4e-05 24.5 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 001114410.1_16126001_3 - 6.4e-17 60.9 1.6 2.1e-06 27.2 0.1 3.6 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001114410.1_16126001_3 - 8.4e-05 22.7 0.2 0.022 14.9 0.1 3.1 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 001114410.1_16126001_3 - 0.0013 18.5 0.3 1.5 8.7 0.0 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand UPF0020 PF01170.16 204368.1_23524001_3 - 1e-10 41.5 0.0 3.2e-10 39.9 0.0 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.14 204368.1_23524001_3 - 0.00061 19.0 0.0 0.0013 18.0 0.0 1.4 1 1 0 1 1 1 1 N-6 DNA Methylase N6_N4_Mtase PF01555.16 204368.1_23524001_3 - 0.016 14.8 0.2 1.4 8.5 0.0 2.4 2 0 0 2 2 2 0 DNA methylase Myb_DNA-bind_4 PF13837.4 001109786.1_23526001_2 - 2.6e-21 75.7 0.0 5.2e-21 74.7 0.0 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.7 001109786.1_23526001_2 - 0.1 12.8 0.1 0.1 12.8 0.1 2.1 3 0 0 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Mannosyl_trans PF05007.11 001031522.2_23524001_3 - 6.6e-99 330.8 17.6 8.4e-99 330.5 17.6 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.11 001031522.2_23524001_3 - 2.3e-17 63.0 6.2 2.3e-17 63.0 6.2 1.5 1 1 1 2 2 2 1 GPI transamidase subunit PIG-U DUF2029 PF09594.8 001031522.2_23524001_3 - 2.6e-05 23.9 25.2 2.6e-05 23.9 25.2 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF2029) MgtE PF01769.14 001031522.2_23524001_3 - 8.4 6.7 12.8 0.31 11.3 4.1 2.7 1 1 1 2 2 2 0 Divalent cation transporter Ribosomal_L7Ae PF01248.24 001279661.1_37521001_3 - 8.8e-29 99.0 1.1 1.1e-28 98.7 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.4 001279661.1_37521001_3 - 0.034 13.9 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 PELOTA RNA binding domain EF-hand_1 PF00036.30 001198744.1_23522001_1 - 1.4e-08 33.5 3.4 1.8e-05 23.8 0.9 4.1 5 0 0 5 5 5 1 EF hand EF-hand_7 PF13499.4 001198744.1_23522001_1 - 9.3e-08 32.3 0.0 0.00085 19.6 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001198744.1_23522001_1 - 1.3e-06 27.8 2.0 4.5e-05 22.9 0.4 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.4 001198744.1_23522001_1 - 6.8e-06 25.6 1.7 0.0023 17.6 0.4 3.8 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.4 001198744.1_23522001_1 - 0.00032 19.9 1.1 0.00032 19.9 1.1 2.3 3 0 0 3 3 3 1 EF hand Serpin PF00079.18 001279558.1_37525001_2 - 4.6e-76 256.4 0.6 4.6e-76 256.4 0.6 1.5 2 0 0 2 2 2 1 Serpin (serine protease inhibitor) Ig_3 PF13927.4 001279558.1_37525001_2 - 3.9e-10 40.1 0.0 0.00023 21.6 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001279558.1_37525001_2 - 1.2e-09 38.2 0.0 0.00077 19.5 0.0 2.8 2 1 1 3 3 3 2 Immunoglobulin V-set domain ig PF00047.23 001279558.1_37525001_2 - 1.6e-09 37.6 0.0 0.0019 18.2 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001279558.1_37525001_2 - 1.2e-07 31.9 0.0 0.00036 20.7 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001279558.1_37525001_2 - 0.00024 21.0 0.0 0.48 10.4 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Izumo-Ig PF16706.3 001279558.1_37525001_2 - 0.0026 17.6 0.0 0.44 10.5 0.0 2.5 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain Peptidase_M14 PF00246.22 001305107.1_23529001_2 - 1e-11 45.0 0.0 1.9e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase V-ATPase_H_N PF03224.12 001305107.1_23529001_2 - 9.5e-05 21.7 0.5 0.00054 19.2 0.5 2.1 1 1 0 1 1 1 1 V-ATPase subunit H AstE_AspA PF04952.12 001305107.1_23529001_2 - 0.015 14.2 0.0 0.024 13.6 0.0 1.3 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family Lectin_C PF00059.19 001319007.1_23529001_1 - 6.6e-157 512.5 43.9 7.6e-24 84.4 0.2 8.9 9 0 0 9 9 9 8 Lectin C-type domain fn2 PF00040.17 001319007.1_23529001_1 - 2.4e-15 56.4 9.2 2.4e-15 56.4 9.2 2.6 2 0 0 2 2 2 1 Fibronectin type II domain UL45 PF05473.10 001319007.1_23529001_1 - 2.9e-14 53.0 9.3 8.5e-06 25.4 0.0 5.5 6 1 0 6 6 6 4 UL45 protein, carbohydrate-binding C-type lectin-like Ricin_B_lectin PF00652.20 001319007.1_23529001_1 - 4.5e-08 33.3 0.4 1.2e-07 31.9 0.4 1.7 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Xlink PF00193.15 001319007.1_23529001_1 - 5.7e-08 32.9 11.0 0.28 11.5 0.2 8.1 7 1 1 8 8 8 2 Extracellular link domain Chordopox_A33R PF05966.10 001319007.1_23529001_1 - 3e-05 23.2 2.9 0.32 10.1 0.0 4.9 6 0 0 6 6 6 2 Chordopoxvirus A33R protein DUF4366 PF14283.4 001319007.1_23529001_1 - 0.0077 15.6 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) Intimin_C PF07979.9 001319007.1_23529001_1 - 0.49 10.7 5.6 1.5e+02 2.7 0.1 5.5 6 0 0 6 6 6 0 Intimin C-type lectin domain Integrin_alpha2 PF08441.10 204146.1_23529001_1 - 6.6e-94 315.3 0.0 8.3e-94 314.9 0.0 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 204146.1_23529001_1 - 1.8e-25 88.6 18.0 2.7e-10 40.1 1.2 5.1 5 0 0 5 5 5 3 FG-GAP repeat VCBS PF13517.4 204146.1_23529001_1 - 2.8e-16 59.7 6.7 1e-09 38.7 0.3 3.3 1 1 3 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.4 204146.1_23529001_1 - 1.8e-07 31.2 10.1 0.0087 16.2 0.0 4.1 4 0 0 4 4 4 2 FG-GAP repeat LYRIC PF15686.3 204146.1_23529001_1 - 0.071 12.5 0.1 0.071 12.5 0.1 2.0 2 0 0 2 2 2 0 Lysine-rich CEACAM1 co-isolated protein family TPR_1 PF00515.26 199769.2_16124001_1 - 1.6e-12 46.5 0.8 1.9e-05 24.1 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.15 199769.2_16124001_1 - 1.3e-10 40.5 7.2 0.0061 16.4 0.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.4 199769.2_16124001_1 - 8.2e-10 38.1 0.2 0.00065 19.2 0.0 2.8 1 1 1 2 2 2 2 TPR repeat TPR_9 PF13371.4 199769.2_16124001_1 - 1.9e-08 34.2 0.3 2e-05 24.5 0.1 3.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.4 199769.2_16124001_1 - 2.2e-06 27.5 0.1 0.064 13.5 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 199769.2_16124001_1 - 3.8e-06 26.6 0.0 0.0048 16.9 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.4 199769.2_16124001_1 - 6.3e-05 23.5 1.8 0.14 12.7 0.1 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 199769.2_16124001_1 - 0.00018 21.8 0.8 0.00072 19.9 0.2 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.4 199769.2_16124001_1 - 0.00051 20.5 6.2 0.099 13.4 0.0 4.3 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.4 199769.2_16124001_1 - 0.051 13.7 3.6 6.4 7.0 0.0 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat Rrn6 PF10214.7 199769.2_16124001_1 - 0.15 10.3 2.3 0.22 9.8 2.3 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor TPR_6 PF13174.4 199769.2_16124001_1 - 0.15 12.6 0.5 67 4.3 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat GRP PF07172.9 199769.2_16124001_1 - 0.94 10.1 7.1 1.9 9.1 7.1 1.4 1 0 0 1 1 1 0 Glycine rich protein family DUF2203 PF09969.7 199769.2_16124001_1 - 1.1 9.9 6.7 2.6 8.7 6.7 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) RhoGEF67_u2 PF16614.3 199769.2_16124001_1 - 2.2 8.3 6.3 1.1 9.2 3.8 1.7 2 0 0 2 2 1 0 Unstructured region two on RhoGEF 6 and 7 ATP-synt_E PF05680.10 199769.2_16124001_1 - 2.6 8.3 6.4 7.7 6.8 6.4 1.8 1 0 0 1 1 1 0 ATP synthase E chain PTRF_SDPR PF15237.4 001004584.1_16127001_2 - 6.3e-94 314.1 25.7 6.3e-94 314.1 25.7 1.5 2 0 0 2 2 2 1 PTRF/SDPR family PseudoU_synth_1 PF01416.18 001277884.1_23523001_1 - 5.6e-34 116.7 0.0 9.1e-29 100.0 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase PseudoU_synth_1 PF01416.18 001277883.1_23523001_1 - 4.2e-37 126.8 0.0 8.3e-29 100.1 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase CN_hydrolase PF00795.20 001039288.2_23527001_1 - 7.9e-21 74.4 0.0 1.3e-20 73.7 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Sprouty PF05210.11 001003842.2_16124001_2 - 1.1e-30 106.1 39.9 1.1e-30 106.1 39.9 1.6 2 0 0 2 2 2 1 Sprouty protein (Spry) Cupin_4 PF08007.10 001079723.1_23527001_3 - 1.5e-90 303.8 0.0 2e-90 303.4 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.4 001079723.1_23527001_3 - 4.3e-05 23.3 0.1 0.078 12.6 0.1 2.3 1 1 0 2 2 2 2 Cupin-like domain Cupin_2 PF07883.9 001079723.1_23527001_3 - 0.0022 17.5 0.2 0.034 13.7 0.2 2.3 1 1 0 1 1 1 1 Cupin domain Steroid_dh PF02544.14 001076653.1_16124001_3 - 1.4e-58 197.0 1.2 1.4e-58 197.0 1.2 1.8 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.10 001076653.1_16124001_3 - 1.4e-05 24.6 0.3 3.1e-05 23.5 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Mod_r PF07200.11 001077785.1_16127001_2 - 3.7e-36 124.3 8.5 3.7e-36 124.3 8.5 1.6 2 0 0 2 2 2 1 Modifier of rudimentary (Mod(r)) protein 7tm_1 PF00001.19 001020648.1_16124001_2 - 1.3e-43 149.0 17.4 1.8e-43 148.6 17.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001020648.1_16124001_2 - 1e-09 38.0 20.4 2e-08 33.8 20.4 2.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.7 001020648.1_16124001_2 - 4e-07 29.5 13.6 6.6e-07 28.8 13.6 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 001020648.1_16124001_2 - 0.00088 18.5 16.0 0.00088 18.5 16.0 2.3 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001020648.1_16124001_2 - 0.0011 18.7 13.4 0.0014 18.3 12.7 1.6 1 1 0 1 1 1 1 Olfactory receptor Dynamin_M PF01031.18 001030128.1_16126001_3 - 4.2e-109 364.0 1.5 4.2e-109 364.0 1.5 1.8 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.21 001030128.1_16126001_3 - 2.2e-54 183.9 0.0 5.1e-54 182.7 0.0 1.7 1 0 0 1 1 1 1 Dynamin family GED PF02212.16 001030128.1_16126001_3 - 4.2e-27 94.0 1.2 4.2e-27 94.0 1.2 2.5 3 0 0 3 3 3 1 Dynamin GTPase effector domain PH PF00169.27 001030128.1_16126001_3 - 3.7e-14 53.0 0.7 7.9e-14 51.9 0.7 1.6 1 0 0 1 1 1 1 PH domain MMR_HSR1 PF01926.21 001030128.1_16126001_3 - 0.00012 22.0 0.1 0.00089 19.2 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase DASH_Duo1 PF08651.8 001030128.1_16126001_3 - 0.089 12.4 0.0 22 4.8 0.0 2.9 2 0 0 2 2 2 0 DASH complex subunit Duo1 Turandot PF07240.9 001030128.1_16126001_3 - 0.12 12.2 0.4 0.45 10.4 0.1 2.1 2 0 0 2 2 2 0 Stress-inducible humoral factor Turandot PH_11 PF15413.4 001030128.1_16126001_3 - 0.13 12.6 2.9 0.6 10.4 1.8 2.7 2 1 0 2 2 2 0 Pleckstrin homology domain AAA_28 PF13521.4 001030128.1_16126001_3 - 0.31 11.2 1.3 3.1 7.9 0.0 2.8 2 1 1 3 3 3 0 AAA domain SapB_2 PF03489.15 001311792.1_16121001_1 - 1.4e-09 37.7 0.8 1.4e-09 37.7 0.8 2.2 2 0 0 2 2 2 1 Saposin-like type B, region 2 SapB_1 PF05184.13 001311792.1_16121001_1 - 2.5e-09 36.8 1.1 8.3e-09 35.2 1.1 2.0 1 0 0 1 1 1 1 Saposin-like type B, region 1 TBPIP PF07106.11 001311792.1_16121001_1 - 0.012 15.2 0.6 0.015 15.0 0.6 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) SCRL PF06876.10 001311792.1_16121001_1 - 0.37 10.9 5.3 1.7 8.7 0.7 2.3 1 1 1 2 2 2 0 Plant self-incompatibility response (SCRL) protein V-set PF07686.15 001319011.1_23522001_2 - 5.2e-14 52.2 0.1 1.2e-13 51.0 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain DUF1968 PF09291.8 001319011.1_23522001_2 - 1.1e-07 31.7 0.1 2.2e-07 30.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1968) C1-set PF07654.13 001319011.1_23522001_2 - 0.012 15.9 0.3 0.047 14.0 0.3 2.0 1 1 0 1 1 1 0 Immunoglobulin C1-set domain S_100 PF01023.17 001351396.1_23521001_1 - 0.0039 16.7 0.0 0.0072 15.9 0.0 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain DUF4735 PF15882.3 001351396.1_23521001_1 - 0.025 13.9 0.0 0.03 13.7 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4735) DUF4800 PF16057.3 001351396.1_23521001_1 - 0.029 13.5 0.4 0.035 13.2 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4800) Loricrin PF15847.3 001351422.1_23521001_1 - 0.38 9.7 62.3 0.83 8.5 62.3 1.6 1 1 0 1 1 1 0 Major keratinocyte cell envelope protein Lipase3_N PF03893.14 001351422.1_23521001_2 - 0.15 12.0 1.6 0.34 10.8 1.6 1.7 1 0 0 1 1 1 0 Lipase 3 N-terminal region Cyt_bd_oxida_II PF02322.13 001351422.1_23521001_2 - 4.4 6.5 15.9 5.3 6.2 15.9 1.0 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II Ribosomal_60s PF00428.17 001351422.1_23521001_3 - 0.57 10.6 4.7 0.76 10.2 4.7 1.1 1 0 0 1 1 1 0 60s Acidic ribosomal protein Stealth_CR2 PF11380.6 001319009.1_23522001_1 - 0.38 10.8 0.9 3.7 7.7 0.0 2.3 3 0 0 3 3 3 0 Stealth protein CR2, conserved region 2 Nipped-B_C PF12830.5 001319340.2_23523001_1 - 1.4 8.7 11.0 0.61 9.9 5.9 2.6 2 1 1 3 3 3 0 Sister chromatid cohesion C-terminus Keratin PF02422.14 001277770.2_23522001_3 - 1.8e-39 133.2 13.3 2.5e-39 132.7 13.3 1.2 1 0 0 1 1 1 1 Keratin FH2 PF02181.21 204423.1_23528001_1 - 1.9e-98 329.8 6.4 1.9e-98 329.8 6.4 1.6 2 0 0 2 2 2 1 Formin Homology 2 Domain MA3 PF02847.15 204304.1_23523001_1 - 1.1e-48 163.7 0.7 5.2e-25 87.5 0.8 2.1 2 0 0 2 2 2 2 MA3 domain HABP4_PAI-RBP1 PF04774.13 204304.1_23523001_1 - 0.009 16.7 3.7 0.049 14.3 0.0 2.3 2 0 0 2 2 2 1 Hyaluronan / mRNA binding family Glyco_transf_10 PF00852.17 204428.1_23524001_2 - 1.2e-35 122.7 0.1 1.8e-35 122.1 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 204428.1_23524001_2 - 6.7e-13 48.9 0.0 1.3e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Zona_pellucida PF00100.21 205363.1_23523001_2 - 1.4e-32 113.3 8.7 1.8e-32 113.0 8.7 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain Troponin PF00992.18 213570.1_23522001_1 - 3.8e-37 127.5 0.6 7.5e-37 126.5 0.6 1.5 1 0 0 1 1 1 1 Troponin Troponin-I_N PF11636.6 213570.1_23522001_1 - 3.8e-08 33.0 0.5 9.5e-08 31.7 0.5 1.7 1 0 0 1 1 1 1 Troponin I residues 1-32 RPN13_C PF16550.3 204651.1_23523001_1 - 2.4e-35 121.0 2.2 4e-35 120.2 2.2 1.4 1 0 0 1 1 1 1 UCH-binding domain Proteasom_Rpn13 PF04683.11 204651.1_23523001_1 - 2.4e-33 114.4 0.1 4.1e-33 113.6 0.1 1.4 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor ASXH PF13919.4 204651.1_23523001_1 - 0.0066 16.3 0.2 0.016 15.1 0.0 1.8 2 0 0 2 2 2 1 Asx homology domain SWI-SNF_Ssr4 PF08549.8 204651.1_23523001_1 - 1.2 7.6 6.1 1.5 7.2 6.1 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) ANF_receptor PF01094.26 001008731.1_16126001_1 - 2.1e-64 217.7 1.0 3.1e-64 217.2 1.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 001008731.1_16126001_1 - 5.7e-54 183.3 28.1 9.5e-54 182.5 28.1 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 001008731.1_16126001_1 - 9.4e-14 51.0 15.4 2.2e-13 49.8 15.4 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001008731.1_16126001_1 - 2.7e-05 23.9 0.0 4.8e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Periplasmic binding protein DUF4501 PF14946.4 001008731.1_16126001_1 - 0.027 14.4 1.5 0.055 13.4 1.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) Ephrin_rec_like PF07699.11 001008731.1_16126001_1 - 7.8 6.2 14.8 1.4 8.6 3.6 2.6 1 1 1 2 2 2 0 Putative ephrin-receptor like Sulfotransfer_2 PF03567.12 001030343.1_23525001_3 - 3.8e-51 174.3 0.1 5e-51 173.9 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase family Peptidase_C1 PF00112.21 001006043.1_16123001_2 - 4.5e-46 157.6 11.7 5.7e-46 157.2 11.7 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.13 001006043.1_16123001_2 - 0.011 14.4 0.5 0.017 13.8 0.5 1.2 1 0 0 1 1 1 0 Peptidase C1-like family Glyco_transf_6 PF03414.11 001030683.1_23527001_1 - 5.5e-138 459.0 0.0 7.4e-138 458.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 6 FYVE PF01363.19 001039304.1_23525001_3 - 3.7e-08 33.3 11.2 3.7e-08 33.3 11.2 2.2 2 0 0 2 2 2 1 FYVE zinc finger FYVE_2 PF02318.14 001039304.1_23525001_3 - 9e-06 25.8 12.1 0.00057 20.0 7.2 2.6 2 0 0 2 2 2 2 FYVE-type zinc finger Reticulon PF02453.15 001039304.1_23525001_3 - 0.0052 16.6 0.6 1.9 8.3 0.1 2.3 2 0 0 2 2 2 2 Reticulon ADK_lid PF05191.12 001039304.1_23525001_3 - 0.15 11.9 9.1 1.3 8.9 1.8 3.7 3 1 0 3 3 3 0 Adenylate kinase, active site lid Pex24p PF06398.9 001039304.1_23525001_3 - 0.17 10.7 0.4 0.54 9.0 0.0 1.8 1 1 1 2 2 2 0 Integral peroxisomal membrane peroxin IBR PF01485.19 001039304.1_23525001_3 - 5.4 7.2 16.8 0.099 12.7 7.9 2.8 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain Ints3 PF10189.7 001044932.1_16129001_1 - 1.5e-105 351.3 0.1 2.5e-105 350.6 0.1 1.4 1 0 0 1 1 1 1 Integrator complex subunit 3 HMG_box PF00505.17 131336.1_16127001_3 - 5.6e-26 90.6 3.3 3.1e-25 88.2 3.5 2.2 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.8 131336.1_16127001_3 - 4.6e-08 33.4 0.6 1.1e-07 32.2 0.6 1.6 1 0 0 1 1 1 1 HMG-box domain Peptidase_S30 PF01577.14 131336.1_16127001_3 - 0.62 9.5 4.2 1 8.8 4.2 1.3 1 0 0 1 1 1 0 Potyvirus P1 protease BSP_II PF05432.9 205162.1_23522001_1 - 9.3e-52 176.4 67.8 8.6e-30 104.3 56.2 2.2 1 1 1 2 2 2 2 Bone sialoprotein II (BSP-II) Spore_coat_CotO PF14153.4 205162.1_23522001_1 - 0.18 11.6 19.9 0.32 10.8 19.9 1.4 1 0 0 1 1 1 0 Spore coat protein CotO Mitofilin PF09731.7 205162.1_23522001_1 - 0.23 10.1 16.2 0.27 9.8 16.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein SAPS PF04499.13 205162.1_23522001_1 - 0.3 9.7 10.8 0.31 9.6 10.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Drc1-Sld2 PF11719.6 205162.1_23522001_1 - 0.42 10.0 13.2 0.53 9.6 13.2 1.3 1 0 0 1 1 1 0 DNA replication and checkpoint protein Hid1 PF12722.5 205162.1_23522001_1 - 0.83 7.5 10.0 0.92 7.4 10.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDK2AP PF09806.7 205162.1_23522001_1 - 1.9 8.3 8.8 3 7.7 8.8 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein WRNPLPNID PF15017.4 205162.1_23522001_1 - 4.2 8.2 27.0 3.5 8.4 6.1 3.8 3 0 0 3 3 3 0 Putative WW-binding domain and destruction box Membralin PF09746.7 205162.1_23522001_1 - 4.6 6.1 5.0 5.6 5.8 5.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein FAM60A PF15396.4 205162.1_23522001_1 - 5.7 6.8 5.8 9.2 6.1 5.8 1.3 1 0 0 1 1 1 0 Protein Family FAM60A DUF1387 PF07139.9 205162.1_23522001_1 - 9.1 5.7 15.0 12 5.3 15.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF1943 PF09172.9 001044633.1_23529001_1 - 4.9e-72 242.7 0.1 4.9e-72 242.7 0.1 3.6 3 0 0 3 3 3 1 Domain of unknown function (DUF1943) Vitellogenin_N PF01347.20 001044633.1_23529001_1 - 7.6e-68 229.3 1.4 7.6e-68 229.3 1.4 3.2 3 1 1 4 4 4 1 Lipoprotein amino terminal region DUF1081 PF06448.9 001044633.1_23529001_1 - 3.3e-37 127.2 5.4 4e-37 127.0 0.1 4.3 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1081) ApoB100_C PF12491.6 001044633.1_23529001_1 - 1.4e-25 88.8 2.4 1.4e-25 88.8 2.4 4.2 4 0 0 4 4 4 1 Apolipoprotein B100 C terminal Apolipoprotein PF01442.16 001044633.1_23529001_1 - 0.14 12.0 51.3 0.73 9.6 8.5 6.6 6 1 0 6 6 6 0 Apolipoprotein A1/A4/E domain Retrotrans_gag PF03732.15 001044633.1_23529001_1 - 2.9 8.1 11.6 8.4 6.6 2.8 4.2 2 1 1 3 3 3 0 Retrotransposon gag protein DUF2164 PF09932.7 001044633.1_23529001_1 - 7.1 6.6 8.9 0.48 10.4 0.5 3.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2164) Leader_CPA1 PF08252.9 001351662.1_16126001_1 - 0.14 11.4 0.3 0.36 10.1 0.3 1.7 1 0 0 1 1 1 0 arg-2/CPA1 leader peptide TSC22 PF01166.16 001351662.1_16126001_2 - 0.055 13.7 0.3 0.055 13.7 0.3 4.4 3 1 2 5 5 5 0 TSC-22/dip/bun family IncA PF04156.12 001351662.1_16126001_2 - 0.17 11.5 42.1 0.86 9.2 33.1 3.3 2 1 0 2 2 2 0 IncA protein Histidinol_dh PF00815.18 001351662.1_16126001_2 - 1.5 7.6 4.0 1.1 8.0 2.2 1.6 2 0 0 2 2 2 0 Histidinol dehydrogenase YtxH PF12732.5 001351662.1_16126001_2 - 3.3 8.2 10.4 0.24 11.8 2.4 2.7 2 0 0 2 2 2 0 YtxH-like protein Reo_sigmaC PF04582.10 001351662.1_16126001_2 - 6 6.0 5.3 3.1 7.0 2.3 1.9 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Baculo_PEP_C PF04513.10 001351662.1_16126001_2 - 8.5 6.3 7.5 2.5 8.0 0.0 2.7 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4922 PF16269.3 001077553.1_16124001_1 - 0.14 11.8 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4922) SCF PF02404.13 001105315.1_23522001_2 - 3.3e-105 351.2 6.8 4.4e-69 232.7 0.5 2.0 1 1 1 2 2 2 2 Stem cell factor C1q PF00386.19 001098738.1_16123001_2 - 3e-26 92.0 0.3 4.4e-26 91.4 0.3 1.3 1 0 0 1 1 1 1 C1q domain TPMT PF05724.9 001002569.2_16122001_2 - 2.3e-61 207.1 0.0 2.8e-61 206.8 0.0 1.1 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_11 PF08241.10 001002569.2_16122001_2 - 0.049 14.1 0.0 0.091 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MIG-14_Wnt-bd PF06664.10 001031294.1_23527001_2 - 2e-94 316.0 21.6 3e-94 315.4 21.6 1.3 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion tRNA_U5-meth_tr PF05958.9 001122943.1_16124001_2 - 1e-12 47.6 0.0 1.3e-11 44.0 0.0 2.1 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.4 001122943.1_16124001_2 - 5.2e-08 32.7 0.0 9.4e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 001122943.1_16124001_2 - 1.7e-06 28.5 0.0 4e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 001122943.1_16124001_2 - 0.00026 20.5 0.0 0.00044 19.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.16 001122943.1_16124001_2 - 0.0037 16.5 0.0 0.0063 15.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.11 001122943.1_16124001_2 - 0.0055 16.0 0.0 0.0099 15.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.13 001122943.1_16124001_2 - 0.011 15.2 0.0 0.019 14.5 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_4 PF02390.15 001122943.1_16124001_2 - 0.017 14.4 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase NodS PF05401.9 001122943.1_16124001_2 - 0.022 14.2 0.2 0.039 13.4 0.2 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_11 PF08241.10 001122943.1_16124001_2 - 0.027 15.0 0.0 0.056 14.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_15 PF09445.8 001122943.1_16124001_2 - 0.041 13.5 0.0 0.078 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_23 PF13489.4 001122943.1_16124001_2 - 0.059 13.1 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF3473 PF11959.6 001122943.1_16124001_2 - 0.086 12.7 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3473) MHC_I PF00129.16 194425.1_16123001_1 - 7.7e-43 146.0 3.3 1e-42 145.6 3.3 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 194425.1_16123001_1 - 3.3e-11 43.4 0.0 7.3e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 194425.1_16123001_1 - 0.00028 20.3 0.6 0.00039 19.8 0.6 1.2 1 0 0 1 1 1 1 MHC-I family domain DAP10 PF07213.9 194425.1_16123001_1 - 0.004 17.0 0.1 0.0082 15.9 0.1 1.4 1 0 0 1 1 1 1 DAP10 membrane protein CD99L2 PF12301.6 194425.1_16123001_1 - 0.089 12.9 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 CD99 antigen like protein 2 HTH_28 PF13518.4 194425.1_16123001_1 - 0.13 12.3 0.0 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Cadherin PF00028.15 001351717.1_16127001_3 - 8.8e-91 298.4 0.2 3.9e-20 72.0 0.2 7.2 7 0 0 7 7 7 6 Cadherin domain Cadherin_2 PF08266.10 001351717.1_16127001_3 - 6.1e-17 61.1 0.2 3.7e-10 39.3 0.0 5.1 5 0 0 5 5 5 3 Cadherin-like Cadherin_3 PF16184.3 001351717.1_16127001_3 - 2.9e-08 33.6 4.2 0.017 15.0 0.0 5.1 5 0 0 5 5 5 2 Cadherin-like FAM176 PF14851.4 001351717.1_16127001_3 - 0.0013 18.3 0.4 0.0027 17.2 0.4 1.4 1 0 0 1 1 1 1 FAM176 family PepSY PF03413.17 001351717.1_16127001_3 - 0.038 14.4 0.3 0.23 11.9 0.1 2.5 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Herpes_gE PF02480.14 001351717.1_16127001_3 - 0.052 12.1 0.0 0.088 11.4 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Calci_bind_CcbP PF11535.6 001351717.1_16127001_3 - 0.16 12.3 0.0 0.79 10.1 0.1 2.0 2 0 0 2 2 2 0 Calcium binding BTB PF00651.29 001020663.1_16123001_1 - 1.1e-24 86.7 0.1 1.8e-24 86.0 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain Proteasome PF00227.24 001007178.1_16123001_1 - 1.8e-31 109.0 0.0 6.8e-17 61.4 0.0 2.3 2 0 0 2 2 2 2 Proteasome subunit Sod_Fe_C PF02777.16 204211.1_23523001_2 - 1.2e-38 131.3 0.0 2.2e-38 130.4 0.0 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.20 204211.1_23523001_2 - 1.6e-33 114.9 2.6 2.4e-33 114.3 2.6 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Sushi PF00084.18 001277994.1_23523001_3 - 7.6e-44 148.0 23.4 2.7e-12 47.0 0.5 5.0 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) Sushi_2 PF09014.8 001277994.1_23523001_3 - 4.1e-31 106.7 1.6 4.1e-31 106.7 1.6 1.9 2 0 0 2 2 2 1 Beta-2-glycoprotein-1 fifth domain HRM PF02793.20 001277994.1_23523001_3 - 0.011 15.9 14.3 3.2 8.0 0.1 4.5 4 0 0 4 4 4 0 Hormone receptor domain cEGF PF12662.5 001277994.1_23523001_3 - 0.12 12.2 4.3 6.9 6.6 0.3 3.4 2 0 0 2 2 2 0 Complement Clr-like EGF-like DUF1962 PF09227.8 001277994.1_23523001_3 - 1.8 8.9 4.8 2.4 8.4 0.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1962) Abhydrolase_1 PF00561.18 103454.1_23527120_3 - 1.9e-14 53.8 0.0 2.6e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 103454.1_23527120_3 - 4e-10 40.6 0.3 6.9e-10 39.8 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 103454.1_23527120_3 - 5.7e-08 32.2 0.0 8.3e-08 31.6 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Pyr_redox_2 PF07992.12 001352023.1_23528001_1 - 6.5e-57 192.9 0.1 8e-57 192.6 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 001352023.1_23528001_1 - 1.3e-28 99.3 0.0 2.4e-28 98.4 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 001352023.1_23528001_1 - 1.5e-18 67.0 2.8 1e-15 57.9 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001352023.1_23528001_1 - 2.4e-15 56.4 0.1 6.3e-12 45.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 001352023.1_23528001_1 - 3.5e-05 22.9 0.2 6.5e-05 22.1 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.12 001352023.1_23528001_1 - 0.0002 20.1 0.1 0.001 17.7 0.1 1.9 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.19 001352023.1_23528001_1 - 0.00033 19.9 0.1 0.056 12.6 0.0 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.5 001352023.1_23528001_1 - 0.00071 18.9 0.1 0.001 18.4 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.15 001352023.1_23528001_1 - 0.0043 16.2 0.7 0.0094 15.1 0.1 1.7 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.20 001352023.1_23528001_1 - 0.0069 15.4 0.3 0.013 14.4 0.3 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.4 001352023.1_23528001_1 - 0.026 14.6 0.3 0.026 14.6 0.3 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001352023.1_23528001_1 - 0.06 12.8 0.0 0.099 12.1 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.4 001352023.1_23528001_1 - 0.19 12.1 0.2 7.5 6.9 0.0 2.3 2 0 0 2 2 2 0 Putative NAD(P)-binding 7tm_1 PF00001.19 001279779.1_37523001_2 - 2.8e-48 164.4 20.1 3.6e-48 164.0 20.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001279779.1_37523001_2 - 4.2e-06 26.2 18.8 5.6e-06 25.8 18.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001279779.1_37523001_2 - 0.00014 21.1 12.2 0.00014 21.1 12.2 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001279779.1_37523001_2 - 0.00016 21.4 12.7 0.0008 19.1 12.7 2.0 1 1 0 1 1 1 1 Olfactory receptor Piezo_RRas_bdg PF12166.6 001279779.1_37523001_2 - 0.031 13.4 0.4 0.051 12.7 0.4 1.3 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain TctB PF07331.9 001279779.1_37523001_2 - 6.6 6.9 9.6 0.22 11.7 0.9 2.5 2 1 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family Acetyltransf_1 PF00583.23 001285397.1_37524001_3 - 3.6e-06 27.1 0.0 6.1e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 001285397.1_37524001_3 - 0.0099 16.2 0.0 0.018 15.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.5 001285397.1_37524001_3 - 0.14 12.0 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Glyco_transf_10 PF00852.17 204430.2_23524001_1 - 1.4e-37 128.9 0.1 2.9e-37 127.9 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 204430.2_23524001_1 - 3.5e-11 43.4 0.1 1.2e-10 41.7 0.1 1.9 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal zf-C4 PF00105.16 001279560.2_37527001_1 - 5.9e-32 109.8 12.3 1.7e-31 108.3 12.3 1.9 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001279560.2_37527001_1 - 1.5e-30 106.2 3.6 2.3e-30 105.6 3.6 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor 7tm_2 PF00002.22 204454.1_23523001_1 - 4.4e-78 261.8 23.3 5.6e-78 261.5 23.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 204454.1_23523001_1 - 6.9e-19 67.8 2.2 1.5e-18 66.7 2.2 1.6 1 0 0 1 1 1 1 Hormone receptor domain Pkinase_Tyr PF07714.15 001204816.1_23526001_1 - 2.1e-57 194.2 0.0 3.5e-57 193.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.5 001204816.1_23526001_1 - 1.4e-55 185.7 16.2 3.1e-17 62.8 0.3 5.7 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001204816.1_23526001_1 - 4.9e-48 160.8 26.6 4.4e-10 39.8 0.5 7.8 3 3 6 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.28 001204816.1_23526001_1 - 9.7e-48 158.5 27.4 2.4e-07 30.8 0.0 11.1 12 0 0 12 12 10 8 Ankyrin repeat Pkinase PF00069.23 001204816.1_23526001_1 - 5.4e-46 156.9 0.0 1.2e-45 155.8 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Ank_3 PF13606.4 001204816.1_23526001_1 - 2.3e-40 131.8 19.3 0.00031 20.8 0.2 11.6 12 0 0 12 12 12 7 Ankyrin repeat Ank_5 PF13857.4 001204816.1_23526001_1 - 2.5e-32 110.3 11.9 8.6e-06 25.9 0.2 8.7 2 1 6 9 9 9 7 Ankyrin repeats (many copies) Kdo PF06293.12 001204816.1_23526001_1 - 0.031 13.5 0.0 0.054 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 001204816.1_23526001_1 - 0.034 13.6 1.0 0.11 11.9 0.1 2.0 2 0 0 2 2 2 0 RIO1 family APH PF01636.21 001204816.1_23526001_1 - 0.044 13.6 0.0 0.076 12.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.4 001204816.1_23526001_1 - 0.069 12.3 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like SPATA24 PF15175.4 001204816.1_23526001_1 - 0.091 12.5 0.2 0.14 11.9 0.2 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated protein 24 NTP_transf_7 PF07984.10 001031085.1_23527001_3 - 3.6e-160 532.3 0.1 4.4e-160 532.0 0.1 1.1 1 0 0 1 1 1 1 Nucleotidyltransferase DnaJ PF00226.29 001267575.1_23523001_1 - 3.1e-22 78.3 0.1 6.8e-22 77.2 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain RRM_1 PF00076.20 001267575.1_23523001_1 - 1.9e-05 24.2 0.0 4e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) COX16 PF14138.4 001267575.1_23523001_1 - 2 8.8 5.9 7.9 6.9 5.9 2.0 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 PWWP PF00855.15 001024828.3_23528001_1 - 1.8e-11 44.2 0.1 4.2e-11 43.0 0.1 1.7 1 0 0 1 1 1 1 PWWP domain DNA_methylase PF00145.15 001024828.3_23528001_1 - 1.8e-07 30.7 0.0 4.8e-06 26.0 0.0 2.5 3 0 0 3 3 3 1 C-5 cytosine-specific DNA methylase Tmemb_40 PF10160.7 001030599.2_23528001_1 - 1.2e-91 306.5 12.4 1.8e-91 305.9 12.4 1.3 1 0 0 1 1 1 1 Predicted membrane protein Catalase PF00199.17 001031215.2_23528001_2 - 2.9e-194 645.3 0.0 3.6e-194 645.0 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.10 001031215.2_23528001_2 - 1.4e-19 69.9 0.3 3.8e-19 68.5 0.3 1.8 1 0 0 1 1 1 1 Catalase-related immune-responsive Lamp PF01299.15 205283.2_23525001_2 - 4.7e-124 413.9 11.6 4.3e-117 391.0 7.5 2.1 1 1 1 2 2 2 2 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.10 205283.2_23525001_2 - 2e-07 30.8 1.7 9.8e-07 28.6 0.1 2.2 2 0 0 2 2 2 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Methyltransf_23 PF13489.4 001318432.1_23522001_1 - 5.9e-16 58.7 0.0 8.6e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001318432.1_23522001_1 - 0.00064 20.3 0.0 0.0012 19.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PSY3 PF16836.3 001318432.1_23522001_1 - 0.002 17.6 0.3 0.0051 16.2 0.2 1.6 2 0 0 2 2 2 1 Shu complex component Psy3, DNA-binding description Methyltransf_31 PF13847.4 001318432.1_23522001_1 - 0.0026 17.4 0.1 0.0082 15.8 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain DUF4214 PF13946.4 001318432.1_23522001_1 - 0.1 12.4 0.1 0.56 10.1 0.0 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4214) 7tm_4 PF13853.4 001305217.1_23523001_3 - 1.9e-55 188.5 17.3 2.3e-55 188.2 17.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001305217.1_23523001_3 - 1.1e-23 83.8 17.9 2.4e-23 82.6 17.9 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001305217.1_23523001_3 - 5.3e-06 25.9 18.2 8.7e-06 25.2 18.2 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Baculo_11_kDa PF06143.9 001305217.1_23523001_3 - 0.039 13.4 0.0 0.039 13.4 0.0 2.1 3 0 0 3 3 3 0 Baculovirus 11 kDa family W2 PF02020.16 001006358.2_23524001_1 - 3.5e-21 75.0 6.5 1.2e-20 73.3 4.4 2.6 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon EF-hand_1 PF00036.30 001081697.2_23522001_1 - 3.3e-39 129.4 6.9 1.1e-09 36.9 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 001081697.2_23522001_1 - 1.9e-33 114.6 1.5 1.4e-17 63.8 0.6 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 001081697.2_23522001_1 - 2.4e-31 107.1 8.7 3.7e-14 52.1 0.4 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.4 001081697.2_23522001_1 - 3.5e-30 101.2 1.2 4.3e-09 35.5 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.4 001081697.2_23522001_1 - 1.3e-22 78.1 2.9 2.1e-06 26.8 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.4 001081697.2_23522001_1 - 5.4e-14 52.1 0.1 2e-07 31.1 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 001081697.2_23522001_1 - 6.1e-07 29.2 0.1 0.0028 17.4 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 001081697.2_23522001_1 - 2.8e-06 27.5 0.2 0.0043 17.2 0.1 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.9 001081697.2_23522001_1 - 8.6e-05 23.2 0.0 0.0018 19.0 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.8 001081697.2_23522001_1 - 0.00019 21.3 0.2 0.00045 20.1 0.2 1.7 1 0 0 1 1 1 1 Ca2+ insensitive EF hand UPF0154 PF03672.11 001081697.2_23522001_1 - 0.0011 18.8 0.0 0.63 10.0 0.0 2.8 3 0 0 3 3 2 1 Uncharacterised protein family (UPF0154) Caleosin PF05042.11 001081697.2_23522001_1 - 0.0078 16.0 0.2 0.45 10.3 0.1 2.8 1 1 0 1 1 1 1 Caleosin related protein RNA_pol_Rpb4 PF03874.14 001081697.2_23522001_1 - 0.009 16.2 0.4 1.8 8.8 0.2 2.5 2 1 0 2 2 2 1 RNA polymerase Rpb4 DUF3349 PF11829.6 001081697.2_23522001_1 - 0.013 16.1 0.1 14 6.4 0.0 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) TerB PF05099.11 001081697.2_23522001_1 - 0.05 13.4 0.3 8.4 6.2 0.1 2.3 1 1 1 2 2 2 0 Tellurite resistance protein TerB DUF2267 PF10025.7 001081697.2_23522001_1 - 0.12 12.5 0.0 0.35 11.0 0.0 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) GPHH PF16905.3 001081697.2_23522001_1 - 0.14 11.9 0.0 1.2 8.8 0.0 2.5 3 0 0 3 3 3 0 Voltage-dependent L-type calcium channel, IQ-associated SurA_N_2 PF13623.4 001081697.2_23522001_1 - 0.14 11.9 0.2 0.85 9.3 0.2 2.0 1 1 1 2 2 2 0 SurA N-terminal domain CIAPIN1 PF05093.11 001005834.2_23525001_1 - 1.1e-21 77.1 18.1 1.4e-16 60.7 4.5 2.4 1 1 1 2 2 2 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Methyltransf_11 PF08241.10 001005834.2_23525001_1 - 1.2e-05 25.7 0.0 2.5e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001005834.2_23525001_1 - 3.9e-05 23.4 0.0 9.3e-05 22.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.4 001005834.2_23525001_1 - 0.0018 18.8 0.0 0.0034 17.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001005834.2_23525001_1 - 0.0059 16.4 0.0 0.0097 15.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001005834.2_23525001_1 - 0.096 13.3 0.0 0.17 12.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain adh_short PF00106.23 001279798.2_37524001_3 - 1.1e-45 155.4 0.1 1.6e-45 154.8 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001279798.2_37524001_3 - 5.6e-26 91.4 0.0 7.8e-26 90.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001279798.2_37524001_3 - 0.00062 19.6 0.0 0.0025 17.6 0.0 1.9 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.13 001279798.2_37524001_3 - 0.017 14.1 0.0 0.031 13.3 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.19 001279798.2_37524001_3 - 0.068 12.5 0.2 0.59 9.4 0.1 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Defensin_beta PF00711.17 001348511.1_23523001_1 - 1.7e-09 37.4 8.4 1.7e-09 37.4 8.4 3.7 4 0 0 4 4 4 1 Beta defensin GalKase_gal_bdg PF10509.7 001030557.1_23528001_1 - 5.3e-24 83.4 0.1 1e-23 82.5 0.1 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.24 001030557.1_23528001_1 - 1.5e-12 47.4 0.3 1.5e-12 47.4 0.3 1.9 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.11 001030557.1_23528001_1 - 1e-11 44.9 0.0 2.2e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal OAD_gamma PF04277.11 001030557.1_23528001_2 - 0.8 10.2 6.4 1.5 9.3 6.4 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain 3Beta_HSD PF01073.17 205118.1_23526001_2 - 9e-119 395.5 0.0 1.2e-118 395.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 205118.1_23526001_2 - 1.9e-21 76.5 0.0 2.6e-21 76.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 205118.1_23526001_2 - 9.5e-16 57.9 0.0 1.7e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.10 205118.1_23526001_2 - 2.7e-13 49.5 0.0 9.9e-13 47.7 0.0 1.8 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.13 205118.1_23526001_2 - 2.3e-11 43.2 0.0 3.6e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.4 205118.1_23526001_2 - 6.1e-09 35.9 0.0 9e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 205118.1_23526001_2 - 2.1e-07 30.2 0.0 3.1e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.11 205118.1_23526001_2 - 3.2e-05 23.5 0.0 4.8e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.16 205118.1_23526001_2 - 0.0047 17.0 0.0 0.0087 16.2 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.8 205118.1_23526001_2 - 0.008 16.0 0.1 0.016 15.0 0.1 1.4 1 0 0 1 1 1 1 KR domain IL8 PF00048.18 204712.2_23524001_2 - 0.027 14.5 2.3 0.061 13.3 2.3 1.6 1 0 0 1 1 1 0 Small cytokines (intecrine/chemokine), interleukin-8 like G-alpha PF00503.18 204691.1_23523001_3 - 8.9e-120 399.9 1.5 1.1e-119 399.6 1.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 204691.1_23523001_3 - 4.2e-14 52.2 1.9 1.8e-10 40.4 0.2 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 204691.1_23523001_3 - 0.0016 17.7 0.7 0.89 8.7 0.1 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 204691.1_23523001_3 - 0.0033 17.5 0.3 2.1 8.4 0.1 2.6 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.9 204691.1_23523001_3 - 0.11 11.5 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.4 204691.1_23523001_3 - 0.15 11.6 0.0 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DAP3 PF10236.7 204691.1_23523001_3 - 0.16 11.0 0.4 0.24 10.4 0.4 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 IL1 PF00340.17 001270535.1_23522001_1 - 2.4e-12 46.5 0.0 2.9e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 Interleukin-1 / 18 Filament_head PF04732.12 001270535.1_23522001_2 - 0.65 10.8 5.6 0.82 10.4 4.6 1.6 1 1 0 1 1 1 0 Intermediate filament head (DNA binding) region Ig_2 PF13895.4 001145226.2_23524001_2 - 8.2e-30 102.8 6.4 4e-10 39.8 0.0 4.3 4 0 0 4 4 4 4 Immunoglobulin domain Ig_3 PF13927.4 001145226.2_23524001_2 - 3.4e-21 75.5 0.5 0.00032 21.1 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 001145226.2_23524001_2 - 5.2e-12 45.6 6.6 0.00058 19.8 0.1 4.8 4 1 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 001145226.2_23524001_2 - 1.9e-08 34.1 0.2 0.092 12.7 0.0 4.7 4 1 0 4 4 4 2 Immunoglobulin I-set domain V-set PF07686.15 001145226.2_23524001_2 - 1.8e-05 24.7 9.0 0.33 11.0 0.0 5.8 4 3 1 6 6 6 2 Immunoglobulin V-set domain Pkinase PF00069.23 205580.1_16123001_1 - 5.7e-49 166.7 0.0 1e-48 165.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 205580.1_16123001_1 - 8.8e-42 143.0 0.0 1.2e-41 142.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 205580.1_16123001_1 - 0.0011 18.2 0.0 0.0011 18.2 0.0 1.9 3 0 0 3 3 3 1 Kinase-like Kdo PF06293.12 205580.1_16123001_1 - 0.0024 17.1 0.1 0.0037 16.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 205580.1_16123001_1 - 0.0037 16.8 0.0 0.0037 16.8 0.0 1.9 2 0 0 2 2 2 1 RIO1 family APH PF01636.21 205580.1_16123001_1 - 0.0062 16.4 0.0 0.0093 15.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Tubulin PF00091.23 198818.1_16125001_2 - 4.2e-68 229.3 0.0 6e-68 228.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 198818.1_16125001_2 - 6.7e-42 142.6 0.1 1e-41 141.9 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 198818.1_16125001_2 - 2.7e-05 24.3 0.0 5.6e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.4 198818.1_16125001_2 - 0.038 13.0 0.0 0.067 12.2 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Tubulin_3 PF14881.4 198818.1_16125001_2 - 0.047 13.2 0.0 0.087 12.4 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain Homeobox_KN PF05920.9 199567.1_16125001_2 - 3.6e-17 61.9 1.0 7.4e-17 60.8 1.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 199567.1_16125001_2 - 2.9e-07 30.1 1.2 6.5e-07 28.9 1.2 1.6 1 0 0 1 1 1 1 Homeobox domain Kazal_2 PF07648.13 001039621.1_16123001_3 - 3.5e-11 43.0 6.1 3.5e-11 43.0 6.1 2.6 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain FOLN PF09289.8 001039621.1_16123001_3 - 6.5e-09 35.7 2.6 2.9e-08 33.6 2.6 2.3 1 0 0 1 1 1 1 Follistatin/Osteonectin-like EGF domain EF-hand_6 PF13405.4 001039621.1_16123001_3 - 1.4e-06 27.6 0.1 0.21 11.5 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain Kazal_1 PF00050.19 001039621.1_16123001_3 - 7.1e-06 25.8 10.0 2.4e-05 24.1 10.0 2.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain EF-hand_1 PF00036.30 001039621.1_16123001_3 - 5.5e-05 22.3 0.7 3.8 7.2 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.4 001039621.1_16123001_3 - 0.00015 22.0 1.9 0.00066 20.0 0.9 2.1 2 0 0 2 2 2 1 EF-hand domain pair Pacifastin_I PF05375.11 001039621.1_16123001_3 - 0.00019 21.0 9.0 0.00019 21.0 9.0 2.7 2 0 0 2 2 2 1 Pacifastin inhibitor (LCMII) EF-hand_8 PF13833.4 001039621.1_16123001_3 - 0.14 11.8 0.1 0.39 10.4 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair Pkinase PF00069.23 001079726.1_23528001_2 - 3e-65 220.1 0.0 4.5e-65 219.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001079726.1_23528001_2 - 7.2e-39 133.5 0.0 1.1e-38 133.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.22 001079726.1_23528001_2 - 4.4e-12 45.6 0.0 9.4e-12 44.5 0.0 1.6 1 0 0 1 1 1 1 PB1 domain Kinase-like PF14531.4 001079726.1_23528001_2 - 0.00058 19.1 0.0 0.015 14.5 0.0 2.1 2 0 0 2 2 2 1 Kinase-like IBN_N PF03810.17 001159661.1_16126001_1 - 8.5e-19 67.1 1.0 2.8e-17 62.3 0.0 3.5 3 0 0 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.10 001159661.1_16126001_1 - 0.006 16.5 4.7 0.11 12.4 0.1 4.0 3 0 0 3 3 3 1 Exportin 1-like protein HEAT PF02985.20 001159661.1_16126001_1 - 0.027 14.6 0.1 9.1 6.7 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat HEAT_2 PF13646.4 001159661.1_16126001_1 - 0.059 13.6 0.0 0.41 10.9 0.0 2.5 2 0 0 2 2 2 0 HEAT repeats bZIP_1 PF00170.19 001277887.1_23522001_1 - 1.1e-10 41.3 21.5 1.8e-10 40.6 21.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001277887.1_23522001_1 - 6e-08 32.5 22.4 1.1e-07 31.7 22.4 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 001277887.1_23522001_1 - 4.2e-07 30.3 15.2 6.6e-07 29.6 15.2 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Macoilin PF09726.7 001277887.1_23522001_1 - 0.14 10.5 9.9 0.18 10.2 9.9 1.0 1 0 0 1 1 1 0 Transmembrane protein DUF342 PF03961.11 001277887.1_23522001_1 - 0.37 9.2 3.3 0.44 9.0 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) APG6 PF04111.10 001277887.1_23522001_1 - 1.2 8.3 8.9 1.5 8.0 8.9 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 RTTN_N PF14726.4 001256543.1_23529001_1 - 8.7e-31 106.5 14.0 3.6e-30 104.5 0.0 5.9 5 1 0 6 6 6 2 Rotatin, an armadillo repeat protein, centriole functioning zf-C2HE PF16278.3 001199547.1_23527001_1 - 0.0048 17.2 0.0 0.16 12.3 0.0 2.8 2 0 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger ERM PF00769.17 001199547.1_23527001_1 - 0.0064 16.2 12.8 0.0094 15.7 12.8 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family RBD-FIP PF09457.8 001199547.1_23527001_1 - 0.037 13.8 1.7 0.12 12.2 1.7 1.8 1 1 0 1 1 1 0 FIP domain Chal_sti_synt_N PF00195.17 001199547.1_23527001_1 - 0.17 11.1 0.4 0.29 10.4 0.4 1.3 1 0 0 1 1 1 0 Chalcone and stilbene synthases, N-terminal domain Exonuc_VII_L PF02601.13 001199547.1_23527001_1 - 0.19 11.1 7.0 0.33 10.3 7.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF342 PF03961.11 001199547.1_23527001_1 - 0.59 8.5 7.4 0.86 8.0 7.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) FUSC PF04632.10 001199547.1_23527001_1 - 0.65 8.3 7.8 0.91 7.9 7.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family GrpE PF01025.17 001199547.1_23527001_1 - 1.4 8.4 15.2 15 5.1 15.2 2.1 1 1 0 1 1 1 0 GrpE zf-C2H2 PF00096.24 001199547.1_23527001_1 - 5.8 7.5 7.5 0.64 10.5 0.3 3.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type dCache_2 PF08269.9 001199547.1_23527001_1 - 8.5 5.3 7.4 5.5 5.9 5.8 1.4 1 1 0 1 1 1 0 Cache domain Homeobox PF00046.27 001277718.1_23522001_1 - 1.5e-19 69.4 6.3 3e-19 68.4 6.3 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001277718.1_23522001_1 - 0.046 13.5 1.7 0.35 10.7 0.0 3.0 3 0 0 3 3 3 0 Homeobox KN domain MHC_I PF00129.16 001184719.1_23523001_1 - 4.5e-59 198.9 0.0 5.9e-59 198.5 0.0 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001184719.1_23523001_1 - 5.4e-14 52.3 0.0 1.2e-13 51.2 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001184719.1_23523001_1 - 1.2e-05 25.6 0.0 2.8e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001184719.1_23523001_1 - 3.2e-05 23.9 0.0 0.00011 22.1 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin domain MHC_I_3 PF16497.3 001184719.1_23523001_1 - 0.0022 17.3 0.0 0.0033 16.8 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain MHC_II_beta PF00969.17 001184719.1_23523001_1 - 0.015 15.3 0.0 0.028 14.4 0.0 1.5 1 0 0 1 1 1 0 Class II histocompatibility antigen, beta domain RAMP PF04901.11 001184719.1_23523001_1 - 0.12 12.3 0.6 0.24 11.3 0.6 1.4 1 0 0 1 1 1 0 Receptor activity modifying family Adeno_PX PF05829.10 001184719.1_23523001_1 - 8.3 6.3 8.6 18 5.2 8.6 1.5 1 0 0 1 1 1 0 Adenovirus late L2 mu core protein (Protein X) Aldo_ket_red PF00248.19 001278080.1_23523001_2 - 2.6e-52 177.7 0.0 3.9e-52 177.1 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family G-alpha PF00503.18 200828.1_16125001_1 - 1e-118 396.4 0.3 1.4e-118 396.0 0.3 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 200828.1_16125001_1 - 2.4e-15 56.3 0.3 1.8e-11 43.7 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 200828.1_16125001_1 - 0.00027 20.2 0.5 0.019 14.2 0.1 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 200828.1_16125001_1 - 0.009 16.1 0.8 4.1 7.5 0.0 2.6 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Cyto_heme_lyase PF01265.15 001031275.1_23527001_2 - 1.7e-70 237.8 15.6 7.3e-70 235.7 15.6 1.9 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase SGL PF08450.10 204729.1_23523001_3 - 4.1e-80 268.8 0.1 4.9e-80 268.5 0.1 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Reg_prop PF07494.9 204729.1_23523001_3 - 0.039 14.0 0.0 0.44 10.8 0.0 2.8 4 0 0 4 4 4 0 Two component regulator propeller NHL PF01436.19 204729.1_23523001_3 - 0.13 12.2 0.0 0.37 10.8 0.0 1.7 1 0 0 1 1 1 0 NHL repeat Frizzled PF01534.15 131140.1_16125001_3 - 2.9e-141 470.1 21.5 3.9e-141 469.7 21.5 1.2 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.20 131140.1_16125001_3 - 2.6e-32 111.7 3.1 2.6e-32 111.7 3.1 2.0 3 0 0 3 3 3 1 Fz domain Pkinase PF00069.23 199946.1_16125001_1 - 3.3e-75 252.7 0.0 4.3e-75 252.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 199946.1_16125001_1 - 2.1e-36 125.4 0.2 6.3e-36 123.8 0.2 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase CNPase PF05881.10 205050.1_23526001_2 - 2.6e-119 396.9 0.2 3.4e-119 396.5 0.2 1.2 1 0 0 1 1 1 1 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase) AAA_14 PF13173.4 205050.1_23526001_2 - 0.00062 19.7 0.1 0.035 14.0 0.0 2.2 1 1 1 2 2 2 1 AAA domain 6PF2K PF01591.16 205050.1_23526001_2 - 0.0017 17.6 0.0 1.2 8.3 0.0 2.1 2 0 0 2 2 2 2 6-phosphofructo-2-kinase AAA_16 PF13191.4 205050.1_23526001_2 - 0.0048 17.2 0.1 0.013 15.7 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 205050.1_23526001_2 - 0.0051 16.9 0.2 0.034 14.3 0.2 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.4 205050.1_23526001_2 - 0.0056 16.7 0.1 0.021 14.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.4 205050.1_23526001_2 - 0.0069 16.8 0.0 0.012 16.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.10 205050.1_23526001_2 - 0.0095 15.1 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin NB-ARC PF00931.20 205050.1_23526001_2 - 0.0096 14.8 0.3 0.57 9.0 0.3 2.1 1 1 0 1 1 1 1 NB-ARC domain AAA_30 PF13604.4 205050.1_23526001_2 - 0.013 15.0 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.4 205050.1_23526001_2 - 0.024 14.9 0.0 0.044 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.25 205050.1_23526001_2 - 0.03 14.7 0.0 0.057 13.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_5 PF07728.12 205050.1_23526001_2 - 0.071 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.4 205050.1_23526001_2 - 0.073 12.7 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.4 205050.1_23526001_2 - 0.09 12.9 0.2 0.9 9.6 0.0 2.1 1 1 0 2 2 2 0 AAA domain NACHT PF05729.10 205050.1_23526001_2 - 0.09 12.6 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA PF00004.27 205050.1_23526001_2 - 0.12 12.7 0.0 0.3 11.4 0.0 1.7 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.15 205050.1_23526001_2 - 0.18 11.4 0.0 0.38 10.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein T2SSE PF00437.18 205050.1_23526001_2 - 0.2 10.6 0.0 3.1 6.7 0.0 2.1 1 1 1 2 2 2 0 Type II/IV secretion system protein GDA1_CD39 PF01150.15 001004643.2_16129001_1 - 1.8e-99 333.1 0.2 2.7e-99 332.6 0.2 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Snf7 PF03357.19 001030792.2_23525001_3 - 5.6e-42 143.1 28.4 8.9e-42 142.5 28.4 1.3 1 0 0 1 1 1 1 Snf7 DnaJ-X PF14308.4 001030792.2_23525001_3 - 0.0035 16.7 10.5 0.0063 15.9 10.5 1.4 1 0 0 1 1 1 1 X-domain of DnaJ-containing Ig_3 PF13927.4 001037839.1_23523001_3 - 3.5e-06 27.4 0.4 0.0093 16.4 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001037839.1_23523001_3 - 6.9e-05 22.7 0.0 0.00012 21.9 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 001037839.1_23523001_3 - 0.0019 18.2 0.2 0.0058 16.7 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.23 001037839.1_23523001_3 - 0.0054 16.7 0.1 1.7 8.7 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001037839.1_23523001_3 - 0.029 14.3 0.1 0.081 12.9 0.1 1.6 2 0 0 2 2 2 0 Immunoglobulin I-set domain C1-set PF07654.13 001037839.1_23523001_3 - 0.096 13.0 0.6 2.4 8.6 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin C1-set domain Autophagy_act_C PF03987.13 001037124.1_16123001_1 - 1.8e-17 63.5 0.6 3.2e-17 62.7 0.6 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain FYTT PF07078.9 001031316.1_23526001_1 - 4.4e-128 426.9 16.7 5.6e-128 426.5 16.7 1.1 1 0 0 1 1 1 1 Forty-two-three protein LSM PF01423.20 001002081.1_16122001_3 - 4.2e-14 51.8 0.2 6.2e-14 51.3 0.2 1.3 1 0 0 1 1 1 1 LSM domain SNARE_assoc PF09335.9 001008469.1_23526001_2 - 2.4e-21 76.3 9.5 2.5e-21 76.2 5.9 2.4 2 0 0 2 2 2 1 SNARE associated Golgi protein US22 PF02393.14 001006423.1_23522001_3 - 2e-20 73.2 0.2 8.2e-20 71.2 0.1 1.9 2 0 0 2 2 2 1 US22 like Fasciclin PF02469.20 001030541.1_23526001_3 - 8.5e-106 349.2 0.0 2.6e-27 95.4 0.2 4.4 4 0 0 4 4 4 4 Fasciclin domain 7tm_4 PF13853.4 131748.2_16125001_2 - 2.9e-58 197.7 26.7 4.1e-58 197.2 26.7 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 131748.2_16125001_2 - 8.4e-19 67.7 28.5 3.5e-18 65.7 28.5 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CS PF04969.14 200919.1_16123001_2 - 3.1e-17 63.2 0.7 5.3e-17 62.5 0.1 1.7 2 0 0 2 2 2 1 CS domain Nudc_N PF14050.4 200919.1_16123001_2 - 5.1e-13 48.7 0.1 1.3e-12 47.3 0.1 1.7 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. NuDC PF16273.3 200919.1_16123001_2 - 9.2e-12 45.2 21.7 9.2e-12 45.2 21.7 2.7 1 1 1 2 2 2 1 Nuclear distribution C domain Presenilin PF01080.15 200919.1_16123001_2 - 1.1 7.8 11.0 1.6 7.2 11.0 1.2 1 0 0 1 1 1 0 Presenilin TRAPP PF04051.14 001008451.1_23525001_1 - 1.6e-35 121.8 0.0 2.1e-35 121.4 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Trypsin PF00089.24 204457.1_23523001_2 - 7e-69 231.9 0.0 8.2e-69 231.7 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 204457.1_23523001_2 - 4.3e-06 27.5 0.0 6.4e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 204457.1_23523001_2 - 0.0023 18.2 0.0 0.0046 17.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Arm PF00514.21 001030774.1_23529001_2 - 2.3e-84 275.0 16.9 3.2e-13 49.1 0.0 8.4 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.18 001030774.1_23529001_2 - 3.8e-26 91.1 6.6 6.2e-26 90.5 6.6 1.3 1 0 0 1 1 1 1 Importin beta binding domain Arm_3 PF16186.3 001030774.1_23529001_2 - 6e-23 80.0 1.9 1.4e-22 78.9 1.9 1.6 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_2 PF13646.4 001030774.1_23529001_2 - 4.3e-15 55.7 0.0 3.1e-06 27.3 0.0 4.2 1 1 4 5 5 5 4 HEAT repeats HEAT_EZ PF13513.4 001030774.1_23529001_2 - 2.7e-12 46.7 4.9 1.6e-05 25.1 0.0 5.3 4 2 1 5 5 5 3 HEAT-like repeat HEAT PF02985.20 001030774.1_23529001_2 - 2e-10 39.8 0.7 0.0055 16.7 0.0 6.2 6 1 0 6 6 6 2 HEAT repeat RICTOR_V PF14668.4 001030774.1_23529001_2 - 0.00068 19.7 0.5 1.3 9.2 0.0 4.3 3 1 1 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_C PF11698.6 001030774.1_23529001_2 - 0.0015 18.5 0.0 0.18 11.8 0.0 3.1 3 0 0 3 3 3 1 V-ATPase subunit H Forkhead PF00250.16 001012612.1_23523001_1 - 1.4e-38 131.0 0.0 2e-38 130.4 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain VPS28 PF03997.10 200590.1_16124001_2 - 1.4e-65 220.4 0.2 2e-65 219.9 0.2 1.2 1 0 0 1 1 1 1 VPS28 protein Somatostatin PF03002.13 205336.1_23522001_2 - 4.4e-12 45.6 8.4 1e-11 44.4 8.4 1.7 1 0 0 1 1 1 1 Somatostatin/Cortistatin family Snf7 PF03357.19 001006428.1_23523001_3 - 2.4e-15 56.4 16.7 3.8e-15 55.8 16.7 1.3 1 0 0 1 1 1 1 Snf7 Ist1 PF03398.12 001006428.1_23523001_3 - 0.00054 19.8 7.4 0.00079 19.2 7.4 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway FlxA PF14282.4 001006428.1_23523001_3 - 0.035 14.0 0.6 0.035 14.0 0.6 2.6 3 0 0 3 3 3 0 FlxA-like protein DUF948 PF06103.9 001006428.1_23523001_3 - 0.08 13.1 4.2 0.24 11.6 4.2 1.9 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Mu-like_Pro PF10123.7 001006428.1_23523001_3 - 0.36 10.2 9.8 0.49 9.7 9.8 1.1 1 0 0 1 1 1 0 Mu-like prophage I protein Mt_ATP-synt_D PF05873.10 001006428.1_23523001_3 - 0.78 9.4 8.3 1.3 8.8 0.4 2.3 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) 7tm_1 PF00001.19 131440.1_16123001_1 - 2.3e-51 174.5 19.0 2.3e-51 174.5 19.0 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 131440.1_16123001_1 - 2.8e-08 33.3 12.2 6.9e-08 32.0 12.2 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Aldedh PF00171.20 212649.1_16124001_3 - 1.1e-83 281.2 0.0 1.3e-83 280.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family AAA_14 PF13173.4 212649.1_16124001_3 - 0.08 12.8 0.2 1.4 8.9 0.2 2.4 1 1 0 1 1 1 0 AAA domain Shisa PF13908.4 001030591.2_23526001_1 - 1.3e-21 77.6 8.0 2.2e-21 76.8 8.0 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Ureide_permease PF07168.9 001030591.2_23526001_2 - 0.03 13.0 0.1 0.046 12.4 0.1 1.1 1 0 0 1 1 1 0 Ureide permease Abhydrolase_6 PF12697.5 199937.1_16124001_3 - 2.7e-25 90.1 0.0 4.4e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 199937.1_16124001_3 - 2e-16 60.3 0.0 4.2e-16 59.2 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 199937.1_16124001_3 - 8.6e-12 44.7 0.1 1.4e-11 44.0 0.1 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.18 199937.1_16124001_3 - 1.6e-05 25.0 0.0 2.7e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.11 199937.1_16124001_3 - 0.0012 18.5 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.23 199937.1_16124001_3 - 0.002 17.9 0.0 0.0053 16.5 0.0 1.7 1 0 0 1 1 1 1 Lipase (class 3) Esterase PF00756.18 199937.1_16124001_3 - 0.0032 17.0 0.1 0.0084 15.6 0.1 1.6 1 1 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.14 199937.1_16124001_3 - 0.0043 16.8 0.6 2 8.0 0.0 2.5 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.11 199937.1_16124001_3 - 0.0043 16.8 0.1 0.0075 16.0 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Rep_fac_C PF08542.9 214737.2_16123001_2 - 2e-21 76.0 0.8 3.2e-21 75.4 0.3 1.6 2 0 0 2 2 1 1 Replication factor C C-terminal domain AAA PF00004.27 214737.2_16123001_2 - 3.8e-17 62.8 0.0 9e-17 61.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.4 214737.2_16123001_2 - 1.2e-11 44.5 0.0 1.9e-09 37.4 0.1 2.3 1 1 1 2 2 2 1 DNA polymerase III, delta subunit Rad17 PF03215.13 214737.2_16123001_2 - 2.2e-10 39.9 0.0 3.5e-06 26.1 0.0 2.1 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_16 PF13191.4 214737.2_16123001_2 - 7.3e-06 26.3 0.1 0.0017 18.6 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_assoc_2 PF16193.3 214737.2_16123001_2 - 0.00011 22.3 0.2 0.0004 20.5 0.0 2.0 2 0 0 2 2 2 1 AAA C-terminal domain AAA_30 PF13604.4 214737.2_16123001_2 - 0.00018 21.2 0.0 0.00069 19.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.4 214737.2_16123001_2 - 0.00023 20.9 0.0 0.00055 19.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.4 214737.2_16123001_2 - 0.00042 20.5 0.0 0.01 16.0 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.4 214737.2_16123001_2 - 0.00085 19.0 0.0 0.0019 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.10 214737.2_16123001_2 - 0.0022 17.1 0.0 0.0044 16.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.19 214737.2_16123001_2 - 0.0024 17.1 0.0 0.037 13.3 0.0 2.3 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.12 214737.2_16123001_2 - 0.0031 17.4 0.0 0.012 15.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.4 214737.2_16123001_2 - 0.0042 17.0 0.1 0.016 15.1 0.0 2.1 3 0 0 3 3 2 1 AAA domain DUF815 PF05673.11 214737.2_16123001_2 - 0.0049 15.9 0.0 0.0093 15.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) DUF2075 PF09848.7 214737.2_16123001_2 - 0.015 14.4 0.0 0.04 13.0 0.0 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.4 214737.2_16123001_2 - 0.016 15.5 0.0 0.11 12.7 0.0 2.1 1 1 0 1 1 1 0 AAA domain DEAD PF00270.27 214737.2_16123001_2 - 0.048 13.3 0.1 0.74 9.4 0.0 2.4 2 1 1 3 3 3 0 DEAD/DEAH box helicase ResIII PF04851.13 214737.2_16123001_2 - 0.064 13.1 0.0 0.27 11.1 0.0 1.9 1 1 0 2 2 2 0 Type III restriction enzyme, res subunit PAM2 PF07145.13 001007832.1_23524001_2 - 1e-06 27.9 0.7 2.3e-06 26.8 0.7 1.5 1 0 0 1 1 1 1 Ataxin-2 C-terminal region 6PF2K PF01591.16 201008.1_16128001_2 - 3.1e-102 340.5 0.7 4.8e-102 339.8 0.7 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.20 201008.1_16128001_2 - 8.5e-40 136.4 0.0 1.2e-39 135.9 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.4 201008.1_16128001_2 - 5.4e-07 29.7 0.0 1e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.8 201008.1_16128001_2 - 0.0092 15.3 0.1 0.015 14.7 0.1 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 His_Phos_2 PF00328.20 204644.1_23524001_3 - 1.4e-34 120.0 0.6 3.8e-34 118.5 0.6 1.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) His_Phos_1 PF00300.20 204644.1_23524001_3 - 0.0015 18.1 0.0 0.012 15.2 0.0 2.0 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) IL8 PF00048.18 204510.1_23522001_2 - 2.4e-07 30.7 1.7 4.6e-07 29.7 1.7 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Alg6_Alg8 PF03155.13 204435.1_23524001_2 - 5.6e-147 490.4 26.6 7.3e-147 490.0 26.6 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family TGF_beta PF00019.18 001006589.2_23524001_1 - 3.9e-28 98.3 0.1 5.9e-28 97.7 0.1 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain ParA PF10609.7 001007833.2_23524001_1 - 4.4e-99 330.8 0.0 5.4e-99 330.5 0.0 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.21 001007833.2_23524001_1 - 5.8e-12 45.6 0.0 2.5e-11 43.6 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.9 001007833.2_23524001_1 - 1.6e-07 30.7 0.0 4.5e-07 29.3 0.0 1.6 1 1 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.4 001007833.2_23524001_1 - 1.8e-07 31.1 0.1 7.7e-07 29.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.13 001007833.2_23524001_1 - 1.4e-06 27.7 0.4 6.8e-06 25.4 0.1 2.1 2 1 1 3 3 3 1 Anion-transporting ATPase AAA_26 PF13500.4 001007833.2_23524001_1 - 3.6e-05 23.5 0.0 0.00023 20.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain ArgK PF03308.14 001007833.2_23524001_1 - 8.9e-05 21.5 0.2 0.00013 21.0 0.2 1.1 1 0 0 1 1 1 1 ArgK protein Fer4_NifH PF00142.16 001007833.2_23524001_1 - 0.00076 18.9 0.0 0.0098 15.2 0.0 2.1 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.10 001007833.2_23524001_1 - 0.011 15.1 0.0 0.02 14.3 0.0 1.4 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.4 001007833.2_23524001_1 - 0.013 14.9 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.18 001007833.2_23524001_1 - 0.022 14.5 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase KTI12 PF08433.8 001007833.2_23524001_1 - 0.085 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 SRP54 PF00448.20 001007833.2_23524001_1 - 0.1 12.1 0.0 0.26 10.8 0.0 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.10 001007833.2_23524001_1 - 0.11 11.7 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin CLP1_P PF16575.3 001007833.2_23524001_1 - 0.13 11.9 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop RMI1_N PF08585.10 001031612.2_23526001_3 - 9.5e-56 188.8 0.0 1.7e-55 188.0 0.0 1.4 1 0 0 1 1 1 1 RecQ mediated genome instability protein RMI1_C PF16099.3 001031612.2_23526001_3 - 5.7e-45 152.5 0.0 1.1e-44 151.6 0.0 1.5 1 0 0 1 1 1 1 Recq-mediated genome instability protein 1, C-terminal OB-fold BCNT PF07572.10 001001189.1_23524001_2 - 3.3e-30 103.8 0.2 3.3e-30 103.8 0.2 2.6 3 1 0 3 3 3 1 Bucentaur or craniofacial development BSP_II PF05432.9 001001189.1_23524001_2 - 0.59 9.7 23.4 0.99 8.9 23.4 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) FancD2 PF14631.4 001001189.1_23524001_2 - 6.4 3.9 7.4 8.8 3.4 7.4 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease FGF PF00167.16 001013264.1_16122001_1 - 4.2e-41 139.8 0.1 5.7e-41 139.4 0.1 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Reductase_C PF14759.4 001013264.1_16122001_1 - 0.027 14.9 0.1 0.079 13.4 0.0 1.9 1 1 1 2 2 2 0 Reductase C-terminal JmjC PF02373.20 001030703.1_23529001_1 - 1.9e-28 99.1 0.0 3.1e-28 98.4 0.0 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.4 001030703.1_23529001_1 - 7.6e-17 61.8 0.1 1.3e-16 61.0 0.1 1.3 1 0 0 1 1 1 1 Cupin-like domain IMUP PF15761.3 001030703.1_23529001_1 - 0.36 11.4 11.5 0.79 10.3 11.5 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein AF-4 PF05110.11 001030703.1_23529001_1 - 1.5 6.7 15.3 2.3 6.1 15.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SWIB PF02201.16 198358.1_16126001_1 - 2.5e-24 84.8 0.2 5.1e-24 83.8 0.2 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain UQ_con PF00179.24 001005838.1_23524001_2 - 2.8e-22 78.8 0.0 4.4e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme V-set PF07686.15 199130.3_16123001_2 - 3.7e-11 43.0 0.0 7.2e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 199130.3_16123001_2 - 0.00027 21.4 0.0 0.00074 19.9 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 199130.3_16123001_2 - 0.0048 16.9 0.1 0.02 15.0 0.1 2.0 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 199130.3_16123001_2 - 0.11 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin I-set domain MCM_bind PF09739.7 001012912.1_23527001_2 - 3.7e-238 791.6 0.0 4.4e-238 791.3 0.0 1.0 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor Med20 PF08612.9 001006327.2_23523001_1 - 3.1e-47 160.7 0.0 4.2e-47 160.3 0.0 1.2 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Prokineticin PF06607.9 001006327.2_23523001_3 - 0.065 13.4 1.3 0.23 11.6 0.1 2.2 2 0 0 2 2 2 0 Prokineticin GCV_H PF01597.17 001006383.1_23522001_1 - 3.1e-07 30.2 0.0 5.1e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Glycine cleavage H-protein DUF2678 PF10856.6 001017748.1_16123001_3 - 1.4e-59 199.0 2.4 2.3e-59 198.3 2.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2678) MgtE PF01769.14 001017748.1_16123001_3 - 0.019 15.2 2.7 0.032 14.5 2.7 1.4 1 0 0 1 1 1 0 Divalent cation transporter V-set PF07686.15 001048080.1_23522001_1 - 2.3e-09 37.3 0.1 3.8e-09 36.5 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001048080.1_23522001_1 - 5.4e-06 26.8 4.1 2.6e-05 24.6 0.7 2.9 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 001048080.1_23522001_1 - 1.6e-05 24.8 2.2 0.00029 20.7 0.2 3.0 1 1 2 3 3 3 1 Immunoglobulin I-set domain ig PF00047.23 001048080.1_23522001_1 - 0.0012 18.9 3.9 0.0025 17.8 0.2 3.0 2 1 1 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.4 001048080.1_23522001_1 - 0.0086 16.3 1.1 0.034 14.3 0.5 2.5 1 1 1 2 2 2 1 Immunoglobulin domain Self-incomp_S1 PF05938.9 001048080.1_23522001_1 - 0.096 13.1 0.1 0.21 12.0 0.1 1.6 1 0 0 1 1 1 0 Plant self-incompatibility protein S1 TMEM154 PF15102.4 001048080.1_23522001_1 - 0.14 11.9 0.1 0.25 11.1 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family MBOAT PF03062.17 001031090.1_23526001_2 - 4.7e-29 101.7 19.0 9.3e-28 97.4 19.0 2.4 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family 7tm_4 PF13853.4 131743.1_16122001_1 - 1.4e-44 152.8 19.5 1.7e-44 152.5 19.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 131743.1_16122001_1 - 1.7e-19 70.0 16.5 3.9e-19 68.8 16.5 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) UPF0197 PF05251.10 131743.1_16122001_1 - 0.018 14.9 3.0 0.4 10.6 0.1 3.5 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0197) MAPEG PF01124.16 001014828.2_16123001_3 - 3.2e-23 81.9 1.2 4.7e-23 81.4 1.2 1.2 1 0 0 1 1 1 1 MAPEG family Cript PF10235.7 001031054.1_23525001_3 - 5.7e-34 116.4 6.2 1.1e-33 115.5 6.2 1.5 1 0 0 1 1 1 1 Microtubule-associated protein CRIPT TPR_9 PF13371.4 200265.1_16123001_3 - 0.00025 21.0 1.6 0.00045 20.2 1.6 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 200265.1_16123001_3 - 0.0068 16.3 1.5 0.6 10.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 200265.1_16123001_3 - 0.021 15.4 6.1 0.36 11.4 1.2 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.4 200265.1_16123001_3 - 0.023 15.1 0.5 0.072 13.5 0.4 1.9 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.4 200265.1_16123001_3 - 0.19 12.3 3.0 0.32 11.6 0.4 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.26 200265.1_16123001_3 - 0.2 11.4 1.6 30 4.5 0.0 3.4 2 1 0 2 2 2 0 Tetratricopeptide repeat KOG2701 PF09762.7 001031262.1_23527001_2 - 1.1e-77 260.2 0.1 1.1e-77 260.2 0.1 4.0 2 1 0 2 2 2 1 Coiled-coil domain-containing protein (DUF2037) Baculo_PEP_C PF04513.10 001031262.1_23527001_2 - 2.2 8.2 11.3 5.3 6.9 6.7 2.9 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Reo_sigmaC PF04582.10 001031262.1_23527001_2 - 4.1 6.6 10.4 0.13 11.5 1.0 2.4 3 0 0 3 3 3 0 Reovirus sigma C capsid protein Nuf2 PF03800.12 204478.3_23525001_3 - 5.2e-34 117.2 0.2 5.2e-34 117.2 0.2 2.7 3 0 0 3 3 3 1 Nuf2 family Filament PF00038.19 204478.3_23525001_3 - 0.0015 18.1 52.5 0.013 15.0 14.5 3.8 1 1 3 4 4 4 3 Intermediate filament protein KASH_CCD PF14662.4 204478.3_23525001_3 - 0.0019 17.9 19.5 0.0019 17.9 19.5 3.2 1 1 2 3 3 3 1 Coiled-coil region of CCDC155 or KASH ATG16 PF08614.9 204478.3_23525001_3 - 0.0062 16.6 26.9 0.0062 16.6 26.9 3.1 1 1 2 3 3 3 1 Autophagy protein 16 (ATG16) HMMR_N PF15905.3 204478.3_23525001_3 - 0.021 14.2 62.3 0.022 14.1 24.0 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Spc7 PF08317.9 204478.3_23525001_3 - 0.93 8.2 59.0 0.44 9.2 26.5 3.1 1 1 2 3 3 3 0 Spc7 kinetochore protein Atg14 PF10186.7 204478.3_23525001_3 - 1.2 8.0 49.1 2.2 7.2 17.6 3.0 1 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Reo_sigmaC PF04582.10 204478.3_23525001_3 - 4 6.6 10.5 2.4 7.3 2.7 2.7 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Abhydrolase_1 PF00561.18 213395.1_16124001_3 - 3.8e-08 33.2 0.0 5.4e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 213395.1_16124001_3 - 0.0009 19.8 0.0 0.0012 19.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.12 213395.1_16124001_3 - 0.0073 14.9 0.0 0.012 14.3 0.0 1.2 1 0 0 1 1 1 1 Ndr family Hydrolase_4 PF12146.6 213395.1_16124001_3 - 0.018 14.2 0.0 0.027 13.6 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.5 213395.1_16124001_3 - 0.037 13.6 0.0 0.067 12.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.18 213395.1_16124001_3 - 0.071 13.1 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 Thioesterase domain A_deaminase PF00962.20 001006290.2_23526001_1 - 1.7e-98 329.9 0.0 2e-98 329.6 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase CTF_NFI PF00859.16 205270.1_23523001_1 - 1.6e-06 28.2 0.1 2.5e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region CTF_NFI PF00859.16 205270.1_23523001_2 - 5.7e-71 239.7 0.4 1.1e-70 238.8 0.4 1.4 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N PF10524.7 205270.1_23523001_2 - 1.2e-27 95.4 2.6 1.9e-27 94.7 2.6 1.4 1 0 0 1 1 1 1 Nuclear factor I protein pre-N-terminus MH1 PF03165.14 205270.1_23523001_2 - 4.2e-11 42.8 0.2 6.9e-11 42.1 0.2 1.3 1 0 0 1 1 1 1 MH1 domain 7tm_4 PF13853.4 131744.3_16124001_3 - 6.2e-54 183.5 27.5 8.5e-54 183.0 27.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 131744.3_16124001_3 - 4.4e-18 65.4 29.7 1.2e-17 63.9 29.2 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PRA1 PF03208.17 001002517.2_16123001_3 - 4e-39 133.4 1.8 5.6e-39 132.9 1.8 1.2 1 0 0 1 1 1 1 PRA1 family protein Halogen_Hydrol PF10112.7 001002517.2_16123001_3 - 0.5 10.2 2.1 8.7 6.2 2.1 2.1 1 1 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein EF-hand_1 PF00036.30 199570.1_16125001_3 - 2.8e-40 132.7 9.6 3.3e-09 35.5 0.4 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 199570.1_16125001_3 - 1e-34 118.6 2.7 6.8e-18 64.8 0.7 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 199570.1_16125001_3 - 3.9e-32 109.6 8.9 5.1e-15 54.9 0.4 4.2 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.4 199570.1_16125001_3 - 3.1e-28 95.1 5.1 8.6e-09 34.5 0.1 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.4 199570.1_16125001_3 - 8.9e-25 84.9 6.9 6.6e-06 25.3 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.4 199570.1_16125001_3 - 9.6e-14 51.3 0.2 2.9e-08 33.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 199570.1_16125001_3 - 3.3e-08 33.3 0.2 0.00068 19.4 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 199570.1_16125001_3 - 4.2e-06 26.9 0.0 0.049 13.8 0.0 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.9 199570.1_16125001_3 - 0.00028 21.6 0.0 0.012 16.3 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.8 199570.1_16125001_3 - 0.00055 19.8 0.5 0.0011 18.9 0.1 1.7 2 0 0 2 2 2 1 Ca2+ insensitive EF hand UPF0154 PF03672.11 199570.1_16125001_3 - 0.00099 19.0 0.0 0.32 10.9 0.0 3.1 3 1 0 3 3 3 1 Uncharacterised protein family (UPF0154) DUF1103 PF06513.9 199570.1_16125001_3 - 0.018 14.5 1.5 0.026 14.0 1.5 1.1 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) DUF4497 PF14924.4 199570.1_16125001_3 - 0.068 13.5 0.0 9.8 6.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4497) DUF3349 PF11829.6 199570.1_16125001_3 - 0.16 12.7 0.3 12 6.6 0.0 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) RNA_pol_Rpb4 PF03874.14 199570.1_16125001_3 - 0.18 12.0 0.2 12 6.1 0.1 2.3 2 0 0 2 2 2 0 RNA polymerase Rpb4 EF-hand_7 PF13499.4 201479.1_16125001_2 - 1e-11 45.0 2.8 1e-11 45.0 2.8 3.0 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.30 201479.1_16125001_2 - 6.3e-09 34.6 2.1 0.0012 18.1 0.3 3.3 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 201479.1_16125001_2 - 9.6e-07 28.1 1.6 0.00017 21.1 0.6 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 201479.1_16125001_2 - 0.0023 17.2 0.4 0.82 9.2 0.2 3.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 201479.1_16125001_2 - 0.0025 17.4 0.4 0.81 9.4 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair Med22 PF06179.10 001002144.1_16123001_2 - 1.1e-35 121.9 4.7 1.6e-35 121.3 4.7 1.2 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Bud13 PF09736.7 001039319.2_23525001_1 - 3.7e-48 163.5 12.9 3.7e-48 163.5 12.9 2.2 3 0 0 3 3 3 1 Pre-mRNA-splicing factor of RES complex Drf_FH1 PF06346.10 001039319.2_23525001_2 - 1.6 8.2 11.6 0.12 11.9 6.3 1.8 2 0 0 2 2 2 0 Formin Homology Region 1 XK-related PF09815.7 001012252.1_16125001_2 - 3.6e-118 394.2 31.5 4.2e-118 393.9 31.5 1.0 1 0 0 1 1 1 1 XK-related protein 4HBT PF03061.20 001037399.1_16124001_1 - 0.00029 21.0 0.1 0.49 10.6 0.1 2.9 2 1 1 3 3 3 2 Thioesterase superfamily Ank_4 PF13637.4 214814.1_16129001_3 - 2e-17 63.1 0.3 7.2e-14 51.8 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 214814.1_16129001_3 - 3e-17 62.8 0.0 6e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 214814.1_16129001_3 - 4.1e-14 52.2 0.1 6.8e-06 26.2 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.4 214814.1_16129001_3 - 1.4e-13 49.6 0.0 5.1e-05 23.2 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat SH3_1 PF00018.26 214814.1_16129001_3 - 4.9e-10 38.7 0.4 9.3e-10 37.8 0.4 1.4 1 0 0 1 1 1 1 SH3 domain Ank_5 PF13857.4 214814.1_16129001_3 - 4.9e-10 39.3 0.4 4.9e-08 33.0 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_9 PF14604.4 214814.1_16129001_3 - 1.8e-06 27.6 0.4 3.8e-06 26.5 0.4 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 214814.1_16129001_3 - 2e-05 24.0 0.1 4e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain RA PF00788.21 214814.1_16129001_3 - 0.039 14.5 1.0 0.056 13.9 0.0 1.8 2 0 0 2 2 2 0 Ras association (RalGDS/AF-6) domain Gtr1_RagA PF04670.10 199714.1_16123001_3 - 1.1e-107 358.5 0.9 1.4e-107 358.2 0.9 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.20 199714.1_16123001_3 - 9.6e-09 34.9 0.0 1.9e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Ras family Arf PF00025.19 199714.1_16123001_3 - 1.8e-08 33.9 0.1 4e-08 32.8 0.1 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 199714.1_16123001_3 - 3.8e-08 33.5 0.0 8.8e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.21 199714.1_16123001_3 - 3.5e-06 26.9 0.0 7.2e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 199714.1_16123001_3 - 0.0015 18.0 0.0 0.002 17.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.8 199714.1_16123001_3 - 0.0025 17.2 0.0 0.0039 16.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF258 PF03193.14 199714.1_16123001_3 - 0.011 15.6 0.4 0.67 9.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DLIC PF05783.9 199714.1_16123001_3 - 0.019 13.7 0.2 0.032 12.9 0.2 1.3 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) DUF815 PF05673.11 199714.1_16123001_3 - 0.026 13.6 2.0 0.15 11.1 0.8 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF815) ABC_tran PF00005.25 199714.1_16123001_3 - 0.042 14.2 0.0 0.074 13.4 0.0 1.5 1 0 0 1 1 1 0 ABC transporter PduV-EutP PF10662.7 199714.1_16123001_3 - 0.052 13.2 0.1 0.13 11.9 0.1 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation SecA_DEAD PF07517.12 199714.1_16123001_3 - 0.094 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 SecA DEAD-like domain AAA_29 PF13555.4 199714.1_16123001_3 - 0.18 11.4 0.4 0.33 10.6 0.4 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.18 199714.1_16123001_3 - 0.91 8.5 8.1 1.5 7.8 1.0 2.8 2 1 0 3 3 3 0 G-protein alpha subunit YEATS PF03366.14 001002752.2_16123001_1 - 3.7e-34 116.4 0.4 6.6e-34 115.6 0.4 1.4 1 0 0 1 1 1 1 YEATS family SOGA PF11365.6 001002752.2_16123001_1 - 0.009 17.0 3.4 0.019 16.0 3.4 1.5 1 0 0 1 1 1 1 Protein SOGA Glyco_transf_29 PF00777.16 001001604.1_23523001_1 - 8.6e-75 251.4 0.0 1.2e-74 251.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Defensin_beta_2 PF13841.4 001001607.2_23522001_3 - 0.0081 16.5 5.5 0.009 16.3 3.4 2.2 2 0 0 2 2 2 1 Beta defensin OTU PF02338.17 001006347.1_23527001_2 - 1.5e-32 112.7 0.6 3.3e-32 111.5 0.0 1.9 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.7 001006347.1_23527001_2 - 1.4e-07 31.1 0.9 0.00016 21.1 0.0 2.6 2 1 1 3 3 3 2 Peptidase C65 Otubain IFP_35_N PF07334.11 001006347.1_23527001_2 - 0.53 10.3 9.6 0.21 11.6 6.8 1.7 1 1 1 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF61 PF01886.14 001006347.1_23527001_2 - 0.6 10.0 4.7 1.4 8.8 4.7 1.6 1 0 0 1 1 1 0 Protein of unknown function DUF61 Synuclein PF01387.15 204673.1_23523001_2 - 1.1e-53 180.9 16.2 1.5e-53 180.5 16.2 1.1 1 0 0 1 1 1 1 Synuclein MAP65_ASE1 PF03999.10 001004494.1_16125001_3 - 2.3e-143 478.9 42.1 2.3e-143 478.9 42.1 1.6 1 1 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) VIT1 PF01988.17 001004494.1_16125001_3 - 0.024 14.4 0.4 0.024 14.4 0.4 3.1 3 2 0 3 3 3 0 VIT family TilS_C PF11734.6 001004494.1_16125001_3 - 3.2 7.1 5.8 0.87 8.9 0.1 2.9 3 0 0 3 3 3 0 TilS substrate C-terminal domain TauD PF02668.14 001012575.1_23529001_1 - 4e-37 128.3 0.1 6.2e-37 127.7 0.1 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.10 001012575.1_23529001_1 - 1.2e-12 48.1 0.1 2.2e-12 47.3 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.8 001012575.1_23529001_1 - 0.0074 15.3 0.0 0.018 14.1 0.0 1.5 2 0 0 2 2 2 1 CsiD bZIP_2 PF07716.13 131886.1_16125001_3 - 9.5e-16 57.5 17.4 9.5e-16 57.5 17.4 1.9 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.19 131886.1_16125001_3 - 0.00021 21.2 13.9 0.00055 19.9 13.9 1.6 1 0 0 1 1 1 1 bZIP transcription factor IncA PF04156.12 131886.1_16125001_3 - 0.016 14.9 1.4 0.025 14.2 1.4 1.3 1 0 0 1 1 1 0 IncA protein DivIC PF04977.13 131886.1_16125001_3 - 0.02 14.5 5.4 0.049 13.3 5.4 1.6 1 0 0 1 1 1 0 Septum formation initiator bZIP_Maf PF03131.15 131886.1_16125001_3 - 0.15 12.4 8.5 0.37 11.2 8.5 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor XhlA PF10779.7 131886.1_16125001_3 - 0.27 11.3 2.8 0.57 10.3 2.8 1.5 1 0 0 1 1 1 0 Haemolysin XhlA DUF3450 PF11932.6 131886.1_16125001_3 - 1.3 8.1 8.4 0.072 12.2 2.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) BTG PF07742.10 198363.1_16125001_2 - 2.5e-38 130.3 0.0 4.2e-38 129.6 0.0 1.3 1 0 0 1 1 1 1 BTG family PAM2 PF07145.13 198363.1_16125001_2 - 7.6e-05 22.0 5.5 0.016 14.7 1.4 2.8 2 0 0 2 2 2 2 Ataxin-2 C-terminal region Bromo_TP PF07524.11 001030923.1_23525001_3 - 7.6e-30 102.6 0.5 1.5e-29 101.7 0.2 1.6 2 0 0 2 2 2 1 Bromodomain associated TAF8_C PF10406.7 001030923.1_23525001_3 - 8.6e-22 77.3 1.2 1.9e-21 76.2 1.2 1.7 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term TFIID-31kDa PF02291.13 001030923.1_23525001_3 - 0.00013 21.9 0.1 0.00021 21.2 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP_like PF17027.3 001030923.1_23525001_3 - 0.0013 18.8 0.0 0.0022 18.0 0.0 1.3 1 0 0 1 1 1 1 Histone-fold protein DUF3090 PF11290.6 001030923.1_23525001_3 - 0.066 12.9 0.8 0.093 12.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3090) CENP-S PF15630.4 001030923.1_23525001_3 - 0.094 13.0 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 CENP-S protein CBFD_NFYB_HMF PF00808.21 001030923.1_23525001_3 - 0.17 12.1 0.0 0.34 11.1 0.0 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SepSecS PF05889.11 001031158.1_23529001_2 - 8.3e-178 590.9 0.0 1e-177 590.6 0.0 1.1 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.19 001031158.1_23529001_2 - 9e-05 21.8 0.0 0.00015 21.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase PGM_PMM_I PF02878.14 001031383.1_23525001_1 - 1.8e-36 124.7 0.0 3.3e-36 123.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.14 001031383.1_23525001_1 - 4.1e-24 85.0 0.0 1.2e-23 83.5 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.14 001031383.1_23525001_1 - 2.7e-12 46.7 0.2 1.5e-11 44.3 0.0 2.4 3 0 0 3 3 3 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.18 001031383.1_23525001_1 - 6.6e-06 26.1 0.0 2e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain EF-hand_1 PF00036.30 204422.1_23522001_1 - 2.3e-13 48.5 2.5 1.7e-06 27.0 0.7 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 204422.1_23522001_1 - 2.9e-13 49.9 0.4 5.3e-13 49.1 0.4 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 204422.1_23522001_1 - 1.5e-11 43.1 1.0 1.1e-05 24.8 0.2 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.4 204422.1_23522001_1 - 5.1e-10 38.3 2.5 6.2e-05 22.2 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 204422.1_23522001_1 - 8.3e-06 25.4 0.7 0.041 13.5 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair Toprim_2 PF13155.4 204422.1_23522001_1 - 0.16 12.3 0.1 18 5.8 0.0 2.2 1 1 1 2 2 2 0 Toprim-like MIP PF00230.18 204266.1_23523001_2 - 1.6e-70 237.2 6.4 1.9e-70 237.0 6.4 1.1 1 0 0 1 1 1 1 Major intrinsic protein UCH PF00443.27 199973.1_16125001_3 - 1.2e-49 169.0 0.5 1.5e-49 168.7 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 199973.1_16125001_3 - 4.5e-16 59.2 1.2 1.1e-15 57.9 1.2 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.21 199973.1_16125001_3 - 0.0019 17.8 0.0 0.0039 16.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Peptidase_C98 PF15499.4 199973.1_16125001_3 - 0.008 15.5 0.5 0.017 14.5 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase EssA PF10661.7 199973.1_16125001_3 - 0.22 11.2 0.0 0.22 11.2 0.0 2.0 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA Raftlin PF15250.4 204458.1_23528001_3 - 1.2e-223 743.0 0.4 1.5e-223 742.7 0.4 1.1 1 0 0 1 1 1 1 Raftlin ART PF01129.16 001034826.1_23523001_1 - 5.5e-93 310.2 0.4 6.7e-93 309.9 0.4 1.1 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.12 001034826.1_23523001_1 - 0.0053 16.0 0.0 0.0091 15.2 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Fe-ADH PF00465.17 207086.1_16125001_2 - 7.1e-104 347.4 0.1 8.6e-104 347.1 0.1 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.4 207086.1_16125001_2 - 3.7e-12 46.3 0.0 1.9e-08 34.1 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.4 207086.1_16125001_2 - 0.1 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding protein Lamp PF01299.15 001001749.1_23524001_1 - 4.6e-109 364.6 12.8 2.6e-105 352.3 7.0 2.0 1 1 1 2 2 2 2 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.10 001001749.1_23524001_1 - 4.5e-06 26.4 1.0 4.5e-06 26.4 1.0 1.8 2 0 0 2 2 2 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Adeno_E3_CR2 PF02439.13 001001749.1_23524001_1 - 0.068 12.8 0.3 0.15 11.7 0.3 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 HlyIII PF03006.18 213500.1_16124001_2 - 2.5e-71 239.8 17.2 3.4e-71 239.4 17.2 1.2 1 0 0 1 1 1 1 Haemolysin-III related DUF962 PF06127.9 213500.1_16124001_2 - 0.53 10.3 3.5 0.31 11.0 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF962) MGC-24 PF05283.9 001044791.2_16124001_3 - 4.4e-40 137.2 15.1 4.4e-40 137.2 15.1 1.9 3 0 0 3 3 3 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF4366 PF14283.4 001044791.2_16124001_3 - 0.0022 17.4 0.1 0.0034 16.8 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) bZIP_1 PF00170.19 001077720.1_16127001_3 - 2.2e-08 33.9 15.3 2.2e-08 33.9 15.3 2.0 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.13 001077720.1_16127001_3 - 0.00018 21.4 15.6 0.00018 21.4 15.6 2.2 3 0 0 3 3 3 1 Basic region leucine zipper CENP-H PF05837.10 001077720.1_16127001_3 - 0.035 14.4 3.0 0.11 12.7 3.0 1.8 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF3035 PF11233.6 001077720.1_16127001_3 - 0.069 13.3 6.4 0.31 11.1 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3035) bZIP_Maf PF03131.15 001077720.1_16127001_3 - 0.56 10.6 17.5 0.068 13.6 11.7 2.3 2 0 0 2 2 2 0 bZIP Maf transcription factor ATP-synt_B PF00430.16 001077720.1_16127001_3 - 1.1 9.2 5.9 2.4 8.1 5.9 1.5 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) DUF972 PF06156.11 001077720.1_16127001_3 - 1.2 9.7 8.3 0.12 12.9 3.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF972) 7tm_4 PF13853.4 001130799.1_16122001_1 - 8e-44 150.3 24.7 9.3e-44 150.1 24.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001130799.1_16122001_1 - 5.6e-22 78.1 22.6 1.1e-21 77.1 22.6 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001130799.1_16122001_1 - 0.0056 15.9 29.5 0.012 14.8 29.5 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv DUF1449 PF07290.9 001130799.1_16122001_1 - 3 7.3 6.9 1.3 8.5 0.9 2.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1449) DUF1774 PF08611.8 001130799.1_16122001_1 - 3.2 8.0 7.6 1.1 9.5 0.7 3.1 1 1 2 3 3 3 0 Fungal protein of unknown function (DUF1774) Cyclin_N PF00134.21 001105665.1_16124001_1 - 2.8e-07 30.3 0.5 5.1e-07 29.4 0.2 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cellulase-like PF12876.5 001105665.1_16124001_1 - 0.14 11.4 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Sugar-binding cellulase-like HLH PF00010.24 001110393.1_16126001_2 - 6.1e-11 42.0 5.8 6.4e-11 41.9 0.2 2.5 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Drf_FH1 PF06346.10 001110393.1_16126001_2 - 0.23 11.0 6.2 0.34 10.5 6.2 1.1 1 0 0 1 1 1 0 Formin Homology Region 1 7tm_4 PF13853.4 001128397.1_16122001_1 - 4.5e-42 144.6 24.1 5.4e-42 144.3 24.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001128397.1_16122001_1 - 2.3e-21 76.1 25.6 4.5e-21 75.1 25.6 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001128397.1_16122001_1 - 0.013 14.8 27.0 0.016 14.5 26.3 1.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.19 001130809.1_16122001_1 - 1.1e-09 37.8 26.9 1.1e-09 37.8 26.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001130809.1_16122001_1 - 1.5e-08 34.6 26.1 1.9e-08 34.2 26.1 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001130809.1_16122001_1 - 4.5e-06 26.1 28.4 6.4e-06 25.6 28.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.7 001130809.1_16122001_1 - 0.00023 20.5 29.6 0.00039 19.7 29.6 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 001130809.1_16122001_1 - 0.43 9.8 30.3 0.44 9.8 29.3 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx DUF2976 PF11190.6 001130809.1_16122001_1 - 7.5 6.3 9.7 0.6 9.8 4.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) Kelch_1 PF01344.23 001045136.2_16124001_3 - 4.6e-28 96.4 5.6 9.5e-10 37.8 0.1 5.0 4 1 0 4 4 4 4 Kelch motif Kelch_6 PF13964.4 001045136.2_16124001_3 - 2e-23 81.7 0.7 0.0002 21.4 0.0 5.5 4 1 1 5 5 5 4 Kelch motif Kelch_3 PF13415.4 001045136.2_16124001_3 - 4.8e-15 55.3 0.5 5.6e-05 23.2 0.0 4.7 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_2 PF07646.13 001045136.2_16124001_3 - 8.3e-13 47.6 1.6 0.00022 20.9 0.0 4.8 3 1 0 3 3 3 3 Kelch motif BTB PF00651.29 001045136.2_16124001_3 - 1e-12 48.1 0.9 4.5e-11 42.8 0.1 2.7 2 1 1 3 3 3 1 BTB/POZ domain Kelch_5 PF13854.4 001045136.2_16124001_3 - 2.4e-10 40.0 1.9 0.00017 21.4 0.0 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.4 001045136.2_16124001_3 - 3.7e-10 39.5 1.8 0.022 14.6 0.0 5.5 4 1 0 4 4 4 3 Galactose oxidase, central domain DUF1669 PF07894.10 001089355.1_16125001_2 - 8.4e-99 330.4 0.0 1.3e-98 329.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1669) PLDc_2 PF13091.4 001089355.1_16125001_2 - 2.1e-09 37.2 0.0 3.6e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 PLD-like domain WRNPLPNID PF15017.4 001080652.1_16124001_1 - 7.7 7.4 6.6 4.3 8.2 0.3 2.7 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box CSF-1 PF05337.9 001080076.1_16124001_2 - 1.5e-12 47.7 0.1 2.7e-12 46.9 0.1 1.4 1 0 0 1 1 1 1 Macrophage colony stimulating factor-1 (CSF-1) DUF4604 PF15377.4 001080076.1_16124001_2 - 5.8e-05 23.5 4.5 8.1e-05 23.0 4.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) SR-25 PF10500.7 001080076.1_16124001_3 - 0.1 12.1 23.8 0.16 11.4 23.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein O-ag_pol_Wzy PF14296.4 001080076.1_16124001_3 - 0.38 9.2 4.5 0.53 8.7 4.5 1.1 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy DUF4604 PF15377.4 001080076.1_16124001_3 - 1.1 9.6 18.7 1.5 9.1 18.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) OAD_gamma PF04277.11 001080076.1_16124001_3 - 7.4 7.1 9.9 12 6.4 9.9 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Meis_PKNOX_N PF16493.3 001139477.1_23523001_2 - 1.6e-45 153.2 0.2 2.5e-45 152.6 0.2 1.3 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.9 001139477.1_23523001_2 - 7.1e-21 73.7 1.0 1.4e-20 72.7 1.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 001139477.1_23523001_2 - 2.6e-08 33.4 1.2 4.2e-08 32.7 0.3 1.8 2 0 0 2 2 2 1 Homeobox domain MBD_C PF14048.4 001079751.2_23525001_2 - 3.3e-35 120.5 0.1 5.7e-35 119.8 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of methyl-CpG binding protein 2 and 3 MBDa PF16564.3 001079751.2_23525001_2 - 6.3e-30 103.1 0.8 1.2e-29 102.1 0.8 1.5 1 0 0 1 1 1 1 p55-binding region of Methyl-CpG-binding domain proteins MBD MBD PF01429.17 001079751.2_23525001_2 - 1.3e-07 31.0 0.1 0.00046 19.7 0.0 2.4 2 0 0 2 2 2 2 Methyl-CpG binding domain RasGAP PF00616.17 001079751.2_23525001_2 - 0.087 12.4 0.5 0.16 11.5 0.5 1.4 1 1 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase RNA_pol_3_Rpc31 PF11705.6 001079751.2_23525001_2 - 0.37 10.9 6.0 0.6 10.2 6.0 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 7tm_4 PF13853.4 001130810.1_16122001_1 - 2.7e-42 145.3 28.7 3.4e-42 145.0 28.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001130810.1_16122001_1 - 2.3e-20 72.8 31.3 1.1e-19 70.6 31.1 2.0 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001130810.1_16122001_1 - 7e-05 22.2 30.7 7e-05 22.2 30.7 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 001130810.1_16122001_1 - 0.0063 15.7 33.6 0.01 15.0 33.6 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Snf7 PF03357.19 001080892.1_23525001_3 - 1.2e-40 138.8 21.8 1.2e-40 138.8 21.8 1.7 2 0 0 2 2 2 1 Snf7 Connexin PF00029.17 001113502.1_16123001_1 - 5.1e-94 314.1 0.3 6.6e-94 313.8 0.3 1.1 1 0 0 1 1 1 1 Connexin RasGEF PF00617.17 001082993.1_16128001_2 - 5.4e-49 166.5 0.2 8e-49 166.0 0.2 1.3 1 0 0 1 1 1 1 RasGEF domain Histone PF00125.22 001082993.1_16128001_2 - 9.1e-13 48.6 0.0 1.8e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Sulfotransfer_1 PF00685.25 001139481.1_16122001_1 - 5.6e-72 242.3 0.0 6.8e-72 242.0 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001139481.1_16122001_1 - 9.8e-05 22.7 0.0 0.027 14.7 0.0 2.3 2 0 0 2 2 2 2 Sulfotransferase family 7tm_1 PF00001.19 001082937.1_16122001_1 - 1.6e-10 40.5 21.9 1.6e-10 40.5 21.9 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001082937.1_16122001_1 - 2.5e-09 37.1 16.0 3.8e-09 36.6 15.7 1.5 1 1 0 1 1 1 1 Olfactory receptor CcmD PF04995.12 001082937.1_16122001_1 - 5.6 7.0 7.8 48 4.0 0.0 3.6 3 0 0 3 3 3 0 Heme exporter protein D (CcmD) TRIC PF05197.11 001079758.1_23526001_2 - 9e-80 266.6 7.7 9e-80 266.6 7.7 1.7 2 0 0 2 2 2 1 TRIC channel FGF PF00167.16 001105278.1_16125001_2 - 5.1e-42 142.8 0.1 1e-41 141.8 0.1 1.5 1 0 0 1 1 1 1 Fibroblast growth factor 7tm_1 PF00001.19 001128561.1_16122001_1 - 1.2e-14 54.0 14.1 1.6e-14 53.7 14.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001128561.1_16122001_1 - 0.16 11.1 22.7 0.93 8.6 22.7 2.0 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF3671 PF12420.6 001128561.1_16122001_1 - 0.38 10.7 14.1 1.4e+02 2.4 12.2 2.9 2 1 0 2 2 2 0 Protein of unknown function CitMHS PF03600.14 001128561.1_16122001_1 - 1.1 8.3 8.7 1.5 7.9 8.7 1.1 1 0 0 1 1 1 0 Citrate transporter PP2C PF00481.19 001077600.1_16126001_2 - 2.9e-61 207.2 0.0 3.9e-61 206.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.4 001077600.1_16126001_2 - 2.4e-07 30.5 0.0 7e-07 29.0 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.10 001077600.1_16126001_2 - 0.01 15.7 0.0 0.22 11.3 0.0 2.1 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) CTC1 PF15489.4 001077745.1_16128001_1 - 9.5e-188 626.0 34.3 1.1e-187 625.8 34.3 1.0 1 0 0 1 1 1 1 CST, telomere maintenance, complex subunit CTC1 CTC1_2 PF15491.4 001077745.1_16128001_1 - 1.8e-05 24.1 0.4 0.062 12.4 0.0 4.1 2 1 2 4 4 4 3 CST, telomere maintenance, complex subunit CTC1 7tm_4 PF13853.4 001128388.1_16122001_1 - 1.5e-43 149.4 18.3 1.9e-43 149.1 18.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001128388.1_16122001_1 - 2e-17 63.2 17.9 6.5e-17 61.5 17.9 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001128388.1_16122001_1 - 0.00083 18.6 19.3 0.0031 16.8 19.3 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.19 001128579.1_16122001_1 - 5.2e-12 45.4 20.9 8.2e-12 44.8 20.9 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001128579.1_16122001_1 - 1.5e-05 24.8 19.1 2.2e-05 24.2 19.1 1.3 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001128579.1_16122001_1 - 0.0016 17.7 23.7 0.003 16.9 23.7 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001128579.1_16122001_1 - 0.015 14.5 25.1 0.026 13.7 25.0 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx FLILHELTA PF10306.7 001128579.1_16122001_1 - 0.066 13.5 0.0 0.18 12.1 0.0 1.8 1 0 0 1 1 1 0 Hypothetical protein FLILHELTA HgmA PF04209.11 152966.2_16124001_3 - 9.9e-224 742.6 0.2 1.1e-223 742.4 0.2 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase HIT PF01230.21 001083572.2_16122001_1 - 1e-28 99.8 0.1 1.4e-28 99.3 0.1 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.6 001083572.2_16122001_1 - 1.3e-21 77.1 0.0 1.8e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DUF3906 PF13046.4 001083572.2_16122001_1 - 0.12 12.3 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3906) Forkhead PF00250.16 212914.1_16125001_2 - 6.5e-39 132.0 0.1 1.3e-38 131.0 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain SPT2 PF08243.9 001199594.1_23525001_1 - 6e-22 78.1 24.6 6e-22 78.1 24.6 4.0 4 1 0 4 4 4 1 SPT2 chromatin protein 7tm_1 PF00001.19 001193588.1_23525001_2 - 9e-30 103.7 21.2 1.4e-29 103.1 21.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.4 001193588.1_23525001_2 - 1.2e-14 53.6 8.2 1e-05 25.1 0.7 4.5 2 2 3 5 5 5 3 Leucine rich repeat LRR_5 PF13306.4 001193588.1_23525001_2 - 2.5e-12 46.7 1.5 6.5e-07 29.2 0.2 2.6 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001193588.1_23525001_2 - 0.0087 16.3 10.1 4 7.8 0.3 4.8 3 1 1 4 4 4 1 Leucine Rich repeats (2 copies) UCH PF00443.27 001199582.1_23529001_3 - 5e-49 167.0 0.7 9e-49 166.1 0.7 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 001199582.1_23529001_3 - 5e-30 105.0 0.4 5e-30 105.0 0.4 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_2 PF14560.4 001199582.1_23529001_3 - 1.8e-07 31.4 0.1 0.086 13.2 0.0 4.1 3 0 0 3 3 3 3 Ubiquitin-like domain ubiquitin PF00240.21 001199582.1_23529001_3 - 1.4e-06 27.8 0.2 0.25 11.0 0.0 4.1 3 0 0 3 3 3 2 Ubiquitin family UN_NPL4 PF11543.6 001199582.1_23529001_3 - 0.11 12.8 0.5 18 5.8 0.0 3.2 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 Defensin_beta PF00711.17 001201399.1_23522001_2 - 1.1e-05 25.2 11.6 1.1e-05 25.2 11.6 2.3 2 0 0 2 2 2 1 Beta defensin Defensin_propep PF00879.16 001201399.1_23522001_2 - 0.038 14.2 0.1 0.051 13.8 0.1 1.2 1 0 0 1 1 1 0 Defensin propeptide RabGAP-TBC PF00566.16 001030840.2_23529001_3 - 2.5e-55 187.3 4.8 4.2e-55 186.6 4.8 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain RloB PF13707.4 001030840.2_23529001_3 - 0.81 9.7 5.2 0.3 11.2 0.3 2.3 2 1 0 2 2 2 0 RloB-like protein NRN1 PF15056.4 001198731.1_23523001_1 - 1.5e-39 133.8 0.5 2.4e-39 133.2 0.5 1.3 1 0 0 1 1 1 1 Neuritin protein family Lambda_CIII PF02061.14 001198731.1_23523001_2 - 5.1 7.1 5.9 0.42 10.6 0.3 2.1 2 1 0 2 2 2 0 Lambda Phage CIII 7tm_1 PF00001.19 001039813.2_16123001_3 - 2.6e-55 187.4 11.5 3.5e-55 187.0 11.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001039813.2_16123001_3 - 2.5e-16 59.7 13.1 6.4e-11 42.0 3.8 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001039813.2_16123001_3 - 8e-12 45.3 8.1 2.9e-11 43.5 3.5 2.2 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001039813.2_16123001_3 - 0.00012 21.4 10.5 0.00012 21.4 10.5 2.1 3 0 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx GPR_Gpa2_C PF11970.6 001039813.2_16123001_3 - 0.22 11.5 0.1 0.22 11.5 0.1 2.3 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term Rab3-GTPase_cat PF13890.4 001077788.2_16127001_2 - 4.7e-65 218.1 0.1 1e-64 217.0 0.1 1.6 1 0 0 1 1 1 1 Rab3 GTPase-activating protein catalytic subunit 7tm_4 PF13853.4 001161400.1_16122001_1 - 7.4e-49 166.8 19.0 9.3e-49 166.5 19.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001161400.1_16122001_1 - 3.3e-26 92.0 8.4 3.3e-26 92.0 8.4 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001161400.1_16122001_1 - 3.1e-07 29.9 10.0 3.1e-07 29.9 10.0 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx SPC12 PF06645.11 001161400.1_16122001_1 - 0.8 9.7 0.0 0.8 9.7 0.0 2.9 2 1 1 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) bZIP_2 PF07716.13 001197066.1_16122001_1 - 3.2e-14 52.6 11.8 5.4e-14 51.9 11.8 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.19 001197066.1_16122001_1 - 3.5e-05 23.7 7.3 7.1e-05 22.7 7.3 1.4 1 0 0 1 1 1 1 bZIP transcription factor Vert_IL3-reg_TF PF06529.9 001197066.1_16122001_1 - 0.0017 17.4 0.0 0.0028 16.7 0.0 1.3 1 0 0 1 1 1 1 Vertebrate interleukin-3 regulated transcription factor Tissue_fac PF01108.15 001171592.1_16123001_3 - 4.6e-10 39.1 0.2 1.1e-09 38.0 0.2 1.6 1 0 0 1 1 1 1 Tissue factor Chordopox_A35R PF05989.10 001171592.1_16123001_3 - 0.029 14.1 0.0 0.05 13.4 0.0 1.3 1 0 0 1 1 1 0 Chordopoxvirus A35R protein Condensation PF00668.18 001171592.1_16123001_3 - 0.12 10.9 0.6 0.16 10.4 0.6 1.1 1 0 0 1 1 1 0 Condensation domain Hormone_2 PF00123.18 001242770.1_16122001_3 - 5.3e-28 96.5 1.8 6.4e-14 51.5 0.1 2.4 2 0 0 2 2 2 2 Peptide hormone 7tm_1 PF00001.19 001177450.1_16123001_1 - 8.6e-51 172.6 16.2 1e-50 172.3 16.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001177450.1_16123001_1 - 1.3e-07 31.2 12.1 1.6e-07 30.9 12.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Git3 PF11710.6 001177450.1_16123001_1 - 0.33 10.6 8.8 0.98 9.0 8.8 1.8 1 1 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 TRAPP PF04051.14 001271159.1_23522001_2 - 2.3e-35 121.3 0.0 2.8e-35 121.1 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component V-set PF07686.15 001258319.1_16122001_1 - 1.3e-06 28.4 0.1 3e-06 27.2 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 001258319.1_16122001_1 - 3.1e-05 23.9 0.6 3.1e-05 23.9 0.6 2.2 1 1 1 2 2 2 1 Immunoglobulin domain G6B PF15096.4 001258319.1_16122001_1 - 0.00059 19.5 3.5 0.013 15.1 0.2 2.3 1 1 1 2 2 2 2 G6B family Ig_3 PF13927.4 001258319.1_16122001_1 - 0.00069 20.0 0.4 0.00069 20.0 0.4 2.4 2 1 0 2 2 2 1 Immunoglobulin domain IncA PF04156.12 001258319.1_16122001_1 - 0.003 17.2 0.1 0.0044 16.7 0.1 1.2 1 0 0 1 1 1 1 IncA protein I-set PF07679.14 001258319.1_16122001_1 - 0.007 16.3 0.0 0.021 14.8 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain CD34_antigen PF06365.10 001258319.1_16122001_1 - 0.016 14.6 0.1 0.028 13.9 0.1 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family Rifin_STEVOR PF02009.14 001258319.1_16122001_1 - 0.052 13.3 1.6 0.091 12.5 1.6 1.5 1 0 0 1 1 1 0 Rifin/stevor family Peptidase_M56 PF05569.9 001258319.1_16122001_1 - 0.15 11.1 2.1 0.18 10.8 1.3 1.4 1 1 0 1 1 1 0 BlaR1 peptidase M56 TMEM154 PF15102.4 001258319.1_16122001_1 - 4.9 6.9 19.1 5.5e+02 0.3 19.1 2.4 1 1 0 1 1 1 0 TMEM154 protein family Ion_trans PF00520.29 001289881.1_16126001_3 - 1.6e-33 115.8 14.5 2.4e-33 115.3 14.5 1.2 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.9 001289881.1_16126001_3 - 2.7e-28 97.9 0.8 5.5e-28 96.8 0.8 1.6 1 0 0 1 1 1 1 Transient receptor ion channel II Ank_4 PF13637.4 001289881.1_16126001_3 - 4.2e-11 43.0 0.0 4.2e-05 23.9 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 001289881.1_16126001_3 - 5.4e-11 42.8 0.3 3.2e-06 27.5 0.3 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 001289881.1_16126001_3 - 5.8e-07 29.2 2.9 0.059 13.8 0.1 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.28 001289881.1_16126001_3 - 2.7e-05 24.3 0.3 0.28 11.6 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 001289881.1_16126001_3 - 5.3e-05 23.3 0.0 1.5 9.1 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeats (many copies) PKD_channel PF08016.10 001289881.1_16126001_3 - 0.00042 19.0 17.2 0.01 14.4 17.2 2.6 1 1 0 1 1 1 1 Polycystin cation channel Gp-FAR-1 PF05823.10 001289881.1_16126001_3 - 0.22 11.7 3.3 11 6.1 0.1 3.1 3 0 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) GSHPx PF00255.17 001277854.1_23522001_2 - 3.1e-37 126.3 0.1 3.8e-37 126.0 0.1 1.1 1 0 0 1 1 1 1 Glutathione peroxidase Nbl1_Borealin_N PF10444.7 001276338.1_23523001_3 - 4.6e-16 58.1 5.3 8.6e-16 57.2 5.3 1.5 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal Borealin PF10512.7 001276338.1_23523001_3 - 7.4e-09 35.5 0.7 7.4e-09 35.5 0.7 2.3 2 0 0 2 2 2 1 Cell division cycle-associated protein 8 ALS2CR11 PF15729.3 001276338.1_23523001_3 - 0.064 12.3 4.6 0.093 11.7 4.6 1.2 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 candidate 11 Furin-like_2 PF15913.3 001279577.1_37523001_1 - 1.4e-46 156.9 24.4 3e-46 155.9 24.4 1.6 1 0 0 1 1 1 1 Furin-like repeat, cysteine-rich GRP PF07172.9 001279577.1_37523001_1 - 0.19 12.3 13.6 0.078 13.5 10.9 1.8 2 0 0 2 2 2 0 Glycine rich protein family GSHPx PF00255.17 001163232.2_23523001_2 - 1.2e-34 118.0 0.0 1.8e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase XPG_N PF00752.15 001318984.1_23525001_1 - 3.3e-21 75.5 0.0 7.9e-21 74.3 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.16 001318984.1_23525001_1 - 6.1e-18 64.8 0.5 6.2e-17 61.6 0.0 2.6 2 0 0 2 2 2 1 XPG I-region 7tm_1 PF00001.19 001083043.1_16123001_1 - 2.4e-63 213.7 12.0 3.4e-63 213.3 12.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001083043.1_16123001_1 - 3.1e-14 52.8 15.5 4.1e-14 52.5 15.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001083043.1_16123001_1 - 1.1e-05 24.8 9.1 1.1e-05 24.8 9.1 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001083043.1_16123001_1 - 0.00066 19.4 11.0 0.0011 18.6 7.6 2.1 2 0 0 2 2 2 1 Olfactory receptor FAM222A PF15258.4 001126398.1_16124001_3 - 3.4e-203 676.4 36.9 5.6e-203 675.7 36.9 1.3 1 1 0 1 1 1 1 Protein family of FAM222A TOM6p PF15184.4 001302134.1_23521001_1 - 9.2e-33 111.7 0.3 1.2e-32 111.4 0.3 1.2 1 0 0 1 1 1 1 Mitochondrial import receptor subunit TOM6 homolog Tom6 PF17112.3 001302134.1_23521001_1 - 0.033 13.6 1.0 0.088 12.2 1.0 1.6 1 1 0 1 1 1 0 Mitochondrial import receptor subunit Tom6, fungal 7tm_1 PF00001.19 001082904.1_16122001_2 - 3.7e-56 190.2 13.1 4.6e-56 189.9 13.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001082904.1_16122001_2 - 2.4e-05 23.7 15.4 2.4e-05 23.7 15.4 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Piezo_RRas_bdg PF12166.6 001082904.1_16122001_2 - 0.092 11.8 0.1 0.14 11.3 0.1 1.3 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain ANF_receptor PF01094.26 001045045.1_16126001_1 - 3.8e-86 289.2 0.0 4.7e-86 288.9 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 001045045.1_16126001_1 - 1e-62 211.8 27.6 1.6e-62 211.2 27.6 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 001045045.1_16126001_1 - 8.7e-20 70.3 11.2 1.9e-19 69.2 11.2 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001045045.1_16126001_1 - 8.4e-09 35.4 0.0 1.3e-06 28.3 0.0 2.3 2 0 0 2 2 2 2 Periplasmic binding protein Ephrin_rec_like PF07699.11 001045045.1_16126001_1 - 1.9 8.2 7.6 0.71 9.5 4.4 2.0 2 0 0 2 2 2 0 Putative ephrin-receptor like UPF0139 PF03669.11 001305092.1_23521001_3 - 3.4e-49 164.5 0.9 4e-49 164.3 0.9 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) DUF626 PF04776.10 001305092.1_23521001_3 - 0.048 13.6 0.0 0.064 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF626) DUF4078 PF13300.4 001006140.2_23525001_3 - 1.1e-26 92.8 11.1 1.1e-26 92.8 11.1 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4078) AIF_C PF14721.4 001006140.2_23525001_3 - 3 8.1 4.3 8.8 6.6 1.6 2.7 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Mei5 PF10376.7 001305101.1_23523001_1 - 2.9e-55 187.2 3.8 3.6e-55 186.9 3.8 1.1 1 0 0 1 1 1 1 Double-strand recombination repair protein Mei5_like PF17021.3 001305101.1_23523001_1 - 0.061 13.2 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Putative double-strand recombination repair-like Ig_3 PF13927.4 001311341.1_37523001_1 - 2.2e-13 50.5 5.2 3.4e-08 33.8 0.1 2.9 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001311341.1_37523001_1 - 3.6e-13 49.5 4.0 1.4e-08 34.9 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001311341.1_37523001_1 - 1.3e-07 31.6 11.3 0.0029 17.6 0.6 3.9 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 001311341.1_37523001_1 - 9.8e-06 25.4 2.2 0.00013 21.8 0.3 3.0 2 1 0 2 2 2 1 Immunoglobulin I-set domain V-set PF07686.15 001311341.1_37523001_1 - 1.3e-05 25.2 11.2 0.52 10.4 0.3 4.9 2 1 0 4 4 4 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 001311341.1_37523001_1 - 0.00014 21.7 2.2 0.021 14.8 0.8 2.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain SIT PF15330.4 001311341.1_37523001_1 - 0.00072 19.8 1.5 0.00072 19.8 1.5 2.0 2 1 1 3 3 2 1 SHP2-interacting transmembrane adaptor protein, SIT Tmemb_9 PF05434.9 001311341.1_37523001_1 - 0.0079 15.9 3.0 0.018 14.8 3.0 1.7 1 1 0 1 1 1 1 TMEM9 Sigma_reg_N PF13800.4 001311341.1_37523001_1 - 0.018 15.2 0.4 0.11 12.7 0.2 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Ly49 PF08391.8 001311341.1_37523001_1 - 0.018 15.2 1.8 0.045 14.0 1.8 1.6 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Shisa PF13908.4 001311341.1_37523001_1 - 0.025 14.7 1.9 0.028 14.5 0.0 1.9 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator O-antigen_lig PF13425.4 001311341.1_37523001_1 - 0.054 12.2 0.6 0.076 11.7 0.6 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein EphA2_TM PF14575.4 001311341.1_37523001_1 - 0.057 14.1 2.4 0.15 12.8 2.4 1.8 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF3377 PF11857.6 001311341.1_37523001_1 - 0.15 11.9 1.7 0.39 10.5 1.7 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Vpu PF00558.17 001311341.1_37523001_1 - 0.25 11.0 2.6 0.55 9.9 2.6 1.5 1 0 0 1 1 1 0 Vpu protein TMEM154 PF15102.4 001311341.1_37523001_1 - 0.26 11.1 5.3 0.68 9.7 4.9 2.0 1 1 0 1 1 1 0 TMEM154 protein family Baculo_11_kDa PF06143.9 001311341.1_37523001_1 - 0.65 9.5 4.9 1.6 8.3 4.9 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family IncA PF04156.12 001311341.1_37523001_1 - 1.3 8.6 10.8 4.4 6.9 10.8 1.8 1 1 0 1 1 1 0 IncA protein DUF4446 PF14584.4 001311341.1_37523001_1 - 1.5 8.7 4.6 0.94 9.3 2.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF4578 PF15147.4 001311341.1_37523001_1 - 3.1 8.5 7.0 0.43 11.3 2.5 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF4578) DUF2681 PF10883.6 001311341.1_37523001_1 - 6.6 7.1 7.8 0.37 11.1 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Conotoxin PF02950.15 001311341.1_37523001_1 - 9.8 7.1 6.4 4.3 8.3 0.1 3.0 3 0 0 3 3 2 0 Conotoxin UvrD_C PF13361.4 001030763.2_23529001_1 - 0.006 15.9 0.4 0.011 15.0 0.4 1.5 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain RVT_1 PF00078.25 001030763.2_23529001_1 - 0.013 14.9 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) SH2 PF00017.22 001319870.1_37522001_1 - 1.5e-11 44.1 0.5 3.6e-11 42.8 0.0 1.9 2 0 0 2 2 2 1 SH2 domain SOCS_box PF07525.14 001319870.1_37522001_1 - 3.8e-06 27.0 0.1 7e-06 26.2 0.1 1.4 1 0 0 1 1 1 1 SOCS box SH2_2 PF14633.4 001319870.1_37522001_1 - 0.035 13.4 0.0 0.071 12.4 0.0 1.5 1 0 0 1 1 1 0 SH2 domain NGF PF00243.16 001293109.1_23523001_3 - 3.4e-51 172.1 1.9 4.9e-51 171.6 1.9 1.2 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.3 001293109.1_23523001_3 - 0.0021 18.3 0.3 0.0036 17.6 0.3 1.3 1 0 0 1 1 1 1 Spaetzle Pkinase PF00069.23 001319868.1_37524001_1 - 3.8e-73 246.0 0.0 5.2e-73 245.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001319868.1_37524001_1 - 3.2e-42 144.5 0.0 5e-42 143.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.3 001319868.1_37524001_1 - 8.7e-12 45.4 0.0 4e-11 43.3 0.0 2.2 2 0 0 2 2 2 1 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.4 001319868.1_37524001_1 - 2.6e-07 30.1 0.0 4.4e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001319868.1_37524001_1 - 0.00033 19.9 0.2 0.0006 19.1 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 001319868.1_37524001_1 - 0.00041 19.9 0.3 0.00071 19.1 0.3 1.3 1 0 0 1 1 1 1 RIO1 family YukC PF10140.7 001319868.1_37524001_1 - 0.032 12.9 0.0 0.048 12.3 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC APH PF01636.21 001319868.1_37524001_1 - 0.032 14.0 0.0 0.22 11.3 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family SH2 PF00017.22 001310091.1_37522001_1 - 6.4e-10 38.8 0.0 1.3e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.14 001310091.1_37522001_1 - 0.001 19.3 0.0 0.0019 18.4 0.0 1.5 1 0 0 1 1 1 1 SOCS box SieB PF14163.4 001310091.1_37522001_1 - 0.04 13.3 0.0 0.063 12.6 0.0 1.2 1 0 0 1 1 1 0 Super-infection exclusion protein B SR-25 PF10500.7 001310091.1_37522001_1 - 0.14 11.6 9.1 0.21 11.1 9.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Syntaphilin PF15290.4 001310091.1_37522001_1 - 0.15 11.6 2.8 0.24 10.9 2.8 1.3 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp IMUP PF15761.3 001310091.1_37522001_1 - 0.46 11.1 5.4 0.7 10.5 5.4 1.2 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF4682 PF15733.3 001318425.1_23523001_1 - 2.8e-21 76.3 0.1 7.1e-21 75.0 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4682) Pkinase PF00069.23 001099990.2_16129001_1 - 2.2e-73 246.8 0.0 3.4e-73 246.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.5 001099990.2_16129001_1 - 7.3e-47 157.7 11.2 5.9e-15 55.5 0.1 5.1 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001099990.2_16129001_1 - 6.1e-43 144.5 4.8 1.8e-11 44.2 0.0 7.4 4 1 2 6 6 6 6 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.15 001099990.2_16129001_1 - 2.3e-36 125.3 0.0 5.5e-35 120.8 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Ank_5 PF13857.4 001099990.2_16129001_1 - 8.5e-36 121.3 13.3 8.2e-09 35.5 0.5 7.3 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.4 001099990.2_16129001_1 - 2.1e-34 113.5 11.9 6.3e-05 22.9 0.0 9.3 8 0 0 8 8 8 8 Ankyrin repeat Ank PF00023.28 001099990.2_16129001_1 - 7.8e-33 111.4 14.7 1.3e-05 25.2 0.1 9.2 9 0 0 9 9 9 7 Ankyrin repeat Death PF00531.20 001099990.2_16129001_1 - 3.5e-17 62.2 0.1 5.8e-16 58.3 0.0 2.9 2 1 0 2 2 2 1 Death domain Kdo PF06293.12 001099990.2_16129001_1 - 5.9e-06 25.6 0.0 1.5e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family COR PF16095.3 001099990.2_16129001_1 - 3.8e-05 23.4 0.2 0.00011 22.0 0.0 1.9 2 1 0 2 2 2 1 C-terminal of Roc, COR, domain Roc PF08477.11 001099990.2_16129001_1 - 0.00016 21.8 0.2 0.016 15.3 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase RIO1 PF01163.20 001099990.2_16129001_1 - 0.00019 20.9 0.2 0.00037 20.0 0.2 1.4 1 0 0 1 1 1 1 RIO1 family DUF258 PF03193.14 001099990.2_16129001_1 - 0.009 15.8 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.25 001099990.2_16129001_1 - 0.027 14.9 0.1 0.077 13.4 0.1 1.7 1 0 0 1 1 1 0 ABC transporter APH PF01636.21 001099990.2_16129001_1 - 0.045 13.5 0.1 0.14 11.9 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family AAA_29 PF13555.4 001099990.2_16129001_1 - 0.046 13.3 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Choline_kinase PF01633.18 001099990.2_16129001_1 - 0.088 12.2 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase AAA_23 PF13476.4 001099990.2_16129001_1 - 1 9.7 3.0 1.5 9.1 0.1 2.6 2 1 1 3 3 3 0 AAA domain Gliadin PF13016.4 001030587.2_23526001_1 - 0.039 14.2 0.2 0.074 13.3 0.2 1.4 1 0 0 1 1 1 0 Cys-rich Gliadin N-terminal Mon1 PF03164.12 001030587.2_23526001_2 - 1.1e-143 479.0 0.2 1.3e-143 478.8 0.2 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 CPSF_A PF03178.13 001114681.2_16129001_1 - 1.9e-92 309.9 0.0 1.1e-90 304.1 0.0 2.5 2 0 0 2 2 2 2 CPSF A subunit region MMS1_N PF10433.7 001114681.2_16129001_1 - 2.2e-41 141.8 0.0 2.7e-40 138.3 0.0 2.4 1 1 1 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term dbPDZ_assoc PF16610.3 001145603.1_16129001_1 - 1.5e-42 143.5 11.2 1.5e-42 143.5 11.2 3.5 4 0 0 4 4 4 1 Unstructured region between two PDZ domains on Dlg5 PDZ PF00595.22 001145603.1_16129001_1 - 2e-39 133.7 6.7 1.6e-10 41.1 0.4 4.6 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) Takusan PF04822.11 001145603.1_16129001_1 - 1.5e-30 104.7 0.0 1.5e-30 104.7 0.0 6.7 5 2 1 6 6 6 1 Takusan PDZ_2 PF13180.4 001145603.1_16129001_1 - 4.1e-21 75.0 2.6 0.00067 19.8 0.0 5.6 4 1 1 5 5 5 4 PDZ domain Guanylate_kin PF00625.19 001145603.1_16129001_1 - 1.9e-12 47.1 0.2 1.9e-12 47.1 0.2 5.3 6 1 0 6 6 6 1 Guanylate kinase CARD PF00619.19 001145603.1_16129001_1 - 7.5e-06 25.8 2.5 7.5e-06 25.8 2.5 3.3 3 0 0 3 3 3 1 Caspase recruitment domain Cep57_CLD_2 PF14197.4 001145603.1_16129001_1 - 0.0073 16.2 7.4 0.0073 16.2 7.4 9.1 4 2 1 8 8 8 1 Centrosome localisation domain of PPC89 SH3_1 PF00018.26 001145603.1_16129001_1 - 0.036 13.5 0.0 0.071 12.6 0.0 1.6 1 0 0 1 1 1 0 SH3 domain Lectin_C PF00059.19 001145603.1_16129001_1 - 0.83 10.3 4.7 1.4 9.6 1.8 2.9 3 0 0 3 3 3 0 Lectin C-type domain SOCS_box PF07525.14 001311318.1_37522001_1 - 1.9e-12 47.2 1.3 3.2e-12 46.4 1.3 1.4 1 0 0 1 1 1 1 SOCS box SH2 PF00017.22 001311318.1_37522001_1 - 4.1e-11 42.7 0.0 6.7e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 SH2 domain GRIN_C PF15235.4 204844.2_23526001_1 - 7.9e-41 139.3 0.2 2.9e-40 137.4 0.2 2.0 1 0 0 1 1 1 1 G protein-regulated inducer of neurite outgrowth C-terminus 7tm_1 PF00001.19 001083041.1_16123001_1 - 1.2e-61 208.2 17.0 1.7e-61 207.7 17.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001083041.1_16123001_1 - 5.7e-12 45.4 20.6 7.1e-12 45.1 20.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001083041.1_16123001_1 - 0.0014 17.9 16.3 0.0014 17.9 16.3 1.8 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001083041.1_16123001_1 - 0.026 14.1 13.4 0.24 11.0 13.4 2.0 1 1 0 1 1 1 0 Olfactory receptor Sep15_SelM PF08806.9 001277859.2_23523001_3 - 1.4e-20 73.2 0.0 2e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Sep15/SelM redox domain PDE6_gamma PF04868.10 200837.1_16122001_2 - 5.3e-46 154.7 1.3 8.5e-46 154.0 1.3 1.3 1 0 0 1 1 1 1 Retinal cGMP phosphodiesterase, gamma subunit YdfZ PF14001.4 023326.1_16122120_3 - 0.057 13.8 0.1 0.13 12.6 0.0 1.6 2 0 0 2 2 2 0 YdfZ protein FXa_inhibition PF14670.4 023340.1_16122120_3 - 8.5e-10 38.6 6.4 1.6e-09 37.7 6.4 1.4 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site PH PF00169.27 001100142.1_16124001_3 - 0.0015 18.9 0.0 0.0028 18.0 0.0 1.5 1 0 0 1 1 1 1 PH domain LRR_8 PF13855.4 001100142.1_16124001_3 - 0.024 14.3 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 Leucine rich repeat LisH PF08513.9 001100142.1_16124001_3 - 0.056 13.3 0.1 0.097 12.6 0.1 1.4 1 0 0 1 1 1 0 LisH 7tm_4 PF13853.4 001008754.2_23522001_1 - 2.3e-111 371.9 22.5 2.6e-111 371.7 22.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001008754.2_23522001_1 - 8.4e-22 77.5 23.7 1.8e-21 76.4 23.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001008754.2_23522001_1 - 8.6e-06 25.2 18.3 3.7e-05 23.1 18.3 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx COesterase PF00135.26 001171770.1_23526001_1 - 1.1e-199 664.5 0.0 1.4e-199 664.2 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001171770.1_23526001_1 - 4.3e-07 29.9 0.2 3.1e-06 27.1 0.2 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold SCF PF02404.13 001171770.1_23526001_1 - 0.14 11.3 0.0 2.7 7.1 0.0 2.2 2 0 0 2 2 2 0 Stem cell factor NDUF_C2 PF06374.9 213574.1_23523001_3 - 5.5e-33 113.3 0.0 4.9e-30 103.8 0.0 2.1 2 0 0 2 2 2 2 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) Phospholip_A2_1 PF00068.17 001277914.1_23522001_2 - 7.1e-36 122.9 4.7 9.4e-36 122.5 4.7 1.2 1 0 0 1 1 1 1 Phospholipase A2 Phospholip_A2_2 PF05826.10 001277914.1_23522001_2 - 7.5 6.7 13.9 2.8e+02 1.6 13.9 2.3 1 1 0 1 1 1 0 Phospholipase A2 zf-C2H2 PF00096.24 001083001.1_16125001_2 - 3e-11 43.0 54.5 0.00019 21.5 0.5 8.5 8 0 0 8 8 8 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001083001.1_16125001_2 - 3.9e-08 33.3 62.2 0.0048 17.5 2.0 8.8 8 0 0 8 8 8 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001083001.1_16125001_2 - 3.7e-07 30.2 38.1 0.0089 16.3 0.1 7.7 7 0 0 7 7 7 4 Zinc-finger double domain zf-AD PF07776.13 001083001.1_16125001_2 - 1e-06 28.7 2.5 1e-06 28.7 2.5 3.3 3 0 0 3 3 3 1 Zinc-finger associated domain (zf-AD) CpXC PF14353.4 001083001.1_16125001_2 - 0.026 14.4 11.3 0.19 11.6 0.2 4.3 2 1 2 4 4 4 0 CpXC protein zf-C2H2_6 PF13912.4 001083001.1_16125001_2 - 6.3 6.7 19.5 1.4 8.8 0.1 5.7 5 0 0 5 5 5 0 C2H2-type zinc finger DEAD PF00270.27 001006568.1_23527001_2 - 1.4e-28 99.7 0.0 2.2e-28 99.0 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001006568.1_23527001_2 - 1.8e-25 89.3 0.0 3.7e-25 88.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain BTB PF00651.29 001277641.2_23524001_1 - 3.5e-20 72.1 2.1 3.5e-20 72.1 2.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain zf-C2H2 PF00096.24 001277641.2_23524001_1 - 6.5e-14 51.4 32.1 2.6e-05 24.3 1.2 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001277641.2_23524001_1 - 1.2e-13 50.6 21.6 5.3e-08 32.8 0.1 5.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 001277641.2_23524001_1 - 5.4e-11 42.2 30.3 0.0012 19.3 0.7 4.8 4 0 0 4 4 4 4 C2H2-type zinc finger zf-met PF12874.5 001277641.2_23524001_1 - 0.00054 20.1 23.6 0.01 16.1 0.6 4.0 4 0 0 4 4 3 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 001277641.2_23524001_1 - 0.028 14.1 0.5 0.028 14.1 0.5 4.2 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.5 001277641.2_23524001_1 - 0.032 14.4 20.0 0.53 10.5 8.3 4.2 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-LYAR PF08790.9 001277641.2_23524001_1 - 0.18 11.6 0.1 0.18 11.6 0.1 3.3 3 0 0 3 3 2 0 LYAR-type C2HC zinc finger zf-C2H2_8 PF15909.3 001277641.2_23524001_1 - 0.3 11.3 15.5 0.34 11.1 2.4 3.6 1 1 2 3 3 3 0 C2H2-type zinc ribbon zf-UBP PF02148.17 001277641.2_23524001_1 - 0.47 10.7 10.2 5 7.4 10.2 2.6 1 1 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein ROS_MUCR PF05443.9 001277641.2_23524001_1 - 0.92 9.4 4.0 1.8 8.5 0.3 2.6 1 1 0 2 2 2 0 ROS/MUCR transcriptional regulator protein zf-C2H2_jaz PF12171.6 001277641.2_23524001_1 - 1.6 9.0 21.9 2.3 8.5 4.4 4.6 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 001277641.2_23524001_1 - 8 6.2 30.7 0.73 9.5 0.3 5.0 5 0 0 5 5 5 0 C2H2-type zinc-finger domain zf-C2HE PF16278.3 001277641.2_23524001_1 - 9.8 6.6 23.1 21 5.5 3.0 3.9 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Ribosomal_L7Ae PF01248.24 001252144.2_23522001_1 - 1.1e-22 79.4 0.1 1.5e-22 79.0 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_L31e PF01198.17 001252144.2_23522001_1 - 0.053 13.6 0.8 0.091 12.9 0.8 1.3 1 0 0 1 1 1 0 Ribosomal protein L31e UDP-g_GGTase PF06427.9 001252099.2_23529001_1 - 0 1218.6 5.5 0 1218.3 5.5 1.1 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.18 001252099.2_23529001_1 - 1.4e-06 27.9 0.9 1.4e-06 27.9 0.9 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 8 Rib_recp_KP_reg PF05104.10 001281515.2_23523001_2 - 0.021 15.8 6.5 0.021 15.8 6.5 2.3 2 0 0 2 2 2 0 Ribosome receptor lysine/proline rich region RAWUL PF16207.3 001281515.2_23523001_3 - 5.2e-22 78.1 0.3 1.1e-21 77.1 0.3 1.6 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.4 001281515.2_23523001_3 - 1.2e-10 40.9 6.8 2.5e-10 39.9 6.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001281515.2_23523001_3 - 6.9e-10 38.5 7.0 1.5e-09 37.4 7.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001281515.2_23523001_3 - 5.4e-07 29.6 5.6 1.5e-06 28.2 5.6 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 001281515.2_23523001_3 - 1.6e-06 27.8 6.7 3.2e-06 26.8 6.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001281515.2_23523001_3 - 1e-05 25.6 3.5 3.1e-05 24.0 3.5 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 001281515.2_23523001_3 - 7.9e-05 22.4 10.6 0.00031 20.5 10.6 2.1 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 001281515.2_23523001_3 - 0.0012 18.7 3.5 0.0012 18.7 3.5 1.9 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.4 001281515.2_23523001_3 - 0.0076 16.0 7.0 0.024 14.4 7.0 1.9 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.4 001281515.2_23523001_3 - 0.0079 16.2 8.7 0.02 14.9 8.7 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.5 001281515.2_23523001_3 - 0.031 14.2 2.0 0.062 13.2 2.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.6 001281515.2_23523001_3 - 0.053 13.2 3.2 0.14 11.9 3.2 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.3 001281515.2_23523001_3 - 0.067 13.2 4.4 0.18 11.8 4.4 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 DUF4695 PF15766.3 001145042.2_23522001_1 - 2.1e-47 159.7 2.1 4.3e-47 158.7 2.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4695) BTB PF00651.29 001012290.1_23523001_2 - 2.4e-26 92.0 0.2 3.8e-26 91.3 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.6 001012290.1_23523001_2 - 1.3e-05 25.1 0.1 3.4e-05 23.8 0.1 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3342) STAS PF01740.19 001012290.1_23523001_2 - 0.097 12.2 0.1 0.39 10.2 0.1 1.8 2 0 0 2 2 2 0 STAS domain Ras PF00071.20 001270662.1_23526001_2 - 4.4e-66 221.3 1.1 5.8e-66 220.9 1.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001270662.1_23526001_2 - 3.2e-36 124.1 0.2 6.2e-36 123.1 0.1 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001270662.1_23526001_2 - 2e-16 59.8 0.2 3e-16 59.2 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 001270662.1_23526001_2 - 3.7e-05 23.5 0.4 0.13 12.0 0.1 2.2 1 1 1 2 2 2 2 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 001270662.1_23526001_2 - 0.00012 21.4 0.1 0.00017 20.9 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001270662.1_23526001_2 - 0.00016 21.2 0.1 0.00026 20.5 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.8 001270662.1_23526001_2 - 0.00024 20.5 0.1 0.00037 19.8 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 001270662.1_23526001_2 - 0.00025 21.0 0.0 0.00044 20.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA PF00004.27 001270662.1_23526001_2 - 0.078 13.3 0.0 1.8 8.8 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 001270662.1_23526001_2 - 0.19 12.0 0.0 0.29 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Spc7 PF08317.9 001252309.2_23528001_3 - 0.001 17.9 18.8 0.001 17.9 18.8 5.2 1 1 4 5 5 5 3 Spc7 kinetochore protein DUF948 PF06103.9 001252309.2_23528001_3 - 0.37 11.0 13.1 0.35 11.0 0.3 4.5 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) Osmo_CC PF08946.8 001252309.2_23528001_3 - 2.4 8.4 17.9 3.5 7.8 0.3 5.0 4 0 0 4 4 4 0 Osmosensory transporter coiled coil Reo_sigmaC PF04582.10 001252309.2_23528001_3 - 7.2 5.8 7.6 1.8 7.8 0.4 2.9 2 1 0 3 3 3 0 Reovirus sigma C capsid protein dCMP_cyt_deam_1 PF00383.21 001146044.2_23524001_3 - 2.2e-15 56.2 0.3 3.8e-15 55.5 0.3 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.10 001146044.2_23524001_3 - 5.7e-10 39.4 1.2 1.8e-07 31.3 0.1 2.4 2 1 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region Dynactin_p62 PF05502.11 001146044.2_23524001_3 - 0.053 12.2 1.2 0.092 11.4 1.2 1.3 1 0 0 1 1 1 0 Dynactin p62 family RskA PF10099.7 001252278.2_23522001_1 - 0.09 12.9 1.0 0.14 12.3 1.0 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA MARVEL PF01284.21 001252278.2_23522001_2 - 7.1e-29 100.6 3.0 7.1e-29 100.6 3.0 1.5 2 0 0 2 2 2 1 Membrane-associating domain DUF4064 PF13273.4 001252278.2_23522001_2 - 0.0053 17.0 0.1 3.3 8.0 0.1 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF4064) HRG PF16954.3 001252278.2_23522001_2 - 0.078 13.3 0.7 0.078 13.3 0.7 2.9 2 1 1 3 3 3 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene Keratin PF02422.14 001277771.2_23522001_2 - 6.3e-39 131.4 16.0 9.1e-39 130.9 16.0 1.2 1 0 0 1 1 1 1 Keratin TRC8_N PF13705.4 001030955.1_23525001_3 - 1.1e-184 614.9 40.9 1.2e-184 614.7 40.9 1.0 1 0 0 1 1 1 1 TRC8 N-terminal domain zf-RING_2 PF13639.4 001030955.1_23525001_3 - 2.9e-09 36.9 8.8 2.9e-09 36.9 8.8 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 001030955.1_23525001_3 - 9.2e-09 34.9 7.6 9.2e-09 34.9 7.6 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001030955.1_23525001_3 - 4.2e-08 33.2 6.2 1.4e-07 31.6 6.2 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 001030955.1_23525001_3 - 2.1e-06 27.4 8.0 2.1e-06 27.4 8.0 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001030955.1_23525001_3 - 3.9e-05 23.4 7.9 9.3e-05 22.2 7.9 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.4 001030955.1_23525001_3 - 0.00012 21.7 4.9 0.00027 20.6 4.9 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.4 001030955.1_23525001_3 - 0.00012 21.7 5.3 0.00012 21.7 5.3 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 001030955.1_23525001_3 - 0.00014 21.7 5.7 0.0013 18.6 5.7 2.4 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.4 001030955.1_23525001_3 - 0.00076 19.3 7.1 0.0018 18.1 7.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.3 001030955.1_23525001_3 - 0.001 18.6 6.2 0.001 18.6 6.2 2.0 2 0 0 2 2 2 1 RING-like zinc finger FANCL_C PF11793.6 001030955.1_23525001_3 - 0.13 12.3 8.2 2.2 8.4 8.2 2.6 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_10 PF16685.3 001030955.1_23525001_3 - 0.34 11.0 3.5 0.77 9.8 3.5 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 RINGv PF12906.5 001030955.1_23525001_3 - 0.4 10.7 6.2 1.2 9.2 6.2 1.8 1 0 0 1 1 1 0 RING-variant domain zf-P11 PF03854.12 001030955.1_23525001_3 - 0.92 9.1 5.6 3.3 7.3 5.6 1.9 1 0 0 1 1 1 0 P-11 zinc finger Zf_RING PF16744.3 001030955.1_23525001_3 - 1.1 9.3 6.8 0.38 10.8 3.9 1.7 2 0 0 2 2 1 0 KIAA1045 RING finger FYDLN_acid PF09538.8 001030955.1_23525001_3 - 2.9 8.5 6.7 5.4 7.6 6.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Zn_ribbon_17 PF17120.3 001030955.1_23525001_3 - 3.3 7.3 11.7 0.31 10.6 6.7 1.9 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type 7tm_1 PF00001.19 204625.3_23524001_2 - 2.9e-52 177.4 17.2 3.8e-52 177.0 17.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 204625.3_23524001_2 - 2.3e-15 56.6 13.7 2.9e-15 56.2 13.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 204625.3_23524001_2 - 6.1e-09 35.4 16.4 9.8e-09 34.8 16.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.7 204625.3_23524001_2 - 4e-08 32.8 6.0 7.9e-08 31.9 6.0 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 204625.3_23524001_2 - 6e-06 26.1 6.4 6e-06 26.1 6.4 2.5 2 1 0 2 2 2 1 Olfactory receptor DUF4282 PF14110.4 204625.3_23524001_2 - 3 8.5 7.5 2 9.0 0.6 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4282) zf-BED PF02892.13 001199541.2_23529001_2 - 1.5e-61 204.1 29.5 2e-16 59.6 0.4 4.7 4 0 0 4 4 4 4 BED zinc finger Dimer_Tnp_hAT PF05699.12 001199541.2_23529001_2 - 3.2e-11 42.7 0.6 3.2e-11 42.7 0.6 2.3 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region PyrI_C PF02748.13 001199541.2_23529001_2 - 0.00018 21.2 5.0 2.7 7.8 0.1 4.5 4 0 0 4 4 4 3 Aspartate carbamoyltransferase regulatory chain, metal binding domain zinc_ribbon_9 PF14369.4 001199541.2_23529001_2 - 0.74 10.0 5.0 57 3.9 0.0 3.9 3 0 0 3 3 3 0 zinc-ribbon Ssu72 PF04722.11 001007875.1_23524001_1 - 3.9e-93 310.2 0.4 5e-93 309.8 0.4 1.1 1 0 0 1 1 1 1 Ssu72-like protein CNTF PF01110.15 205492.1_23523001_2 - 3.6e-98 326.6 0.5 4.4e-98 326.2 0.5 1.1 1 0 0 1 1 1 1 Ciliary neurotrophic factor PRF PF06875.9 205492.1_23523001_2 - 0.16 11.3 0.0 0.57 9.4 0.0 1.7 2 0 0 2 2 2 0 Plethodontid receptivity factor PRF Zip PF02535.20 001008471.1_23526001_1 - 1.7e-57 195.0 1.2 2.5e-57 194.5 1.2 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter GCV_H PF01597.17 001004372.1_23522001_2 - 2.7e-46 156.3 0.1 3.4e-46 156.0 0.1 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Myelin_MBP PF01669.15 205280.1_23525001_3 - 6.8e-72 240.9 10.6 9.4e-72 240.4 10.6 1.2 1 0 0 1 1 1 1 Myelin basic protein RELT PF12606.6 001012582.1_23528001_1 - 1.6e-23 81.7 0.8 6e-23 79.8 0.8 2.1 1 0 0 1 1 1 1 Tumour necrosis factor receptor superfamily member 19 SAPS PF04499.13 001031183.1_23529001_3 - 2.7e-104 349.5 11.9 4.7e-66 223.4 7.2 3.6 3 2 1 4 4 4 2 SIT4 phosphatase-associated protein FliC PF12445.6 001031183.1_23529001_3 - 0.02 15.1 1.4 0.048 13.9 1.4 1.6 1 0 0 1 1 1 0 Flagellin protein Glyco_transf_54 PF04666.11 001012824.1_23526001_2 - 8.1e-135 448.1 1.5 1.2e-134 447.6 1.5 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region DUF4750 PF15938.3 001012824.1_23526001_2 - 0.26 10.8 1.0 0.55 9.8 1.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4750) Solute_trans_a PF03619.14 001008468.1_23527001_1 - 1.2e-101 339.6 19.6 1.6e-101 339.2 19.6 1.2 1 0 0 1 1 1 1 Organic solute transporter Ostalpha W2 PF02020.16 001006516.1_23524001_3 - 6.5e-23 80.6 5.2 1.7e-20 72.8 3.6 2.8 2 0 0 2 2 2 2 eIF4-gamma/eIF5/eIF2-epsilon Ras PF00071.20 204525.1_23523001_2 - 8.3e-61 204.2 0.5 1e-60 203.8 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 204525.1_23523001_2 - 1.2e-34 119.0 0.0 2e-34 118.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 204525.1_23523001_2 - 1.8e-11 43.6 0.1 3.3e-11 42.8 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 204525.1_23523001_2 - 0.00047 19.5 0.0 0.00063 19.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 204525.1_23523001_2 - 0.00061 19.7 0.0 0.0011 19.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 204525.1_23523001_2 - 0.0082 15.9 0.7 0.86 9.4 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 204525.1_23523001_2 - 0.02 14.3 0.1 0.043 13.2 0.1 1.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.4 204525.1_23523001_2 - 0.091 13.0 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Bombesin PF02044.15 001277900.1_23522001_1 - 7.3e-07 28.7 4.3 1.6e-06 27.6 4.3 1.6 1 0 0 1 1 1 1 Bombesin-like peptide Ig_3 PF13927.4 212868.1_16129001_1 - 1.1e-47 160.4 9.8 6e-13 49.1 0.2 5.6 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.14 212868.1_16129001_1 - 3e-38 129.6 0.4 1.2e-10 41.2 0.1 5.6 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_2 PF13895.4 212868.1_16129001_1 - 9.4e-33 112.3 3.1 1e-10 41.6 0.1 5.6 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 212868.1_16129001_1 - 9.2e-23 80.1 0.6 2.4e-06 27.5 0.1 5.7 5 0 0 5 5 5 4 Immunoglobulin domain C2-set_2 PF08205.10 212868.1_16129001_1 - 3.5e-15 55.7 1.0 8e-11 41.7 0.0 4.4 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain V-set PF07686.15 212868.1_16129001_1 - 5.2e-12 45.7 3.9 0.023 14.7 0.0 6.2 4 2 1 5 5 5 3 Immunoglobulin V-set domain C1-set PF07654.13 212868.1_16129001_1 - 1.7e-07 31.5 0.3 0.045 14.1 0.0 5.3 5 0 0 5 5 5 1 Immunoglobulin C1-set domain Ig_5 PF16681.3 212868.1_16129001_1 - 1.6e-05 25.1 0.2 0.025 14.9 0.0 4.7 5 1 0 5 5 5 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DUF3188 PF11384.6 212868.1_16129001_1 - 0.0093 15.5 0.4 0.025 14.2 0.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3188) NCBP3 PF10309.7 200143.1_16125001_1 - 2.1e-20 72.2 0.1 3.7e-20 71.4 0.1 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 RNA_bind PF08675.9 200143.1_16125001_1 - 0.07 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 RNA binding domain PBP1_TM PF14812.4 200143.1_16125001_1 - 0.98 9.8 45.8 0.38 11.1 17.1 4.9 4 0 0 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Peptidase_M18 PF02127.13 200153.1_16124001_3 - 4.6e-183 608.8 0.0 5.3e-183 608.6 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.12 200153.1_16124001_3 - 1.5e-07 30.6 0.0 1.3e-05 24.2 0.0 2.7 3 0 0 3 3 3 2 M42 glutamyl aminopeptidase zf-MIZ PF02891.18 001113339.1_16129001_2 - 4.7e-23 80.5 4.5 4.7e-23 80.5 4.5 2.5 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 001113339.1_16129001_2 - 8.4e-06 25.4 1.2 8.4e-06 25.4 1.2 2.2 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-DNL PF05180.10 001080648.1_16123001_3 - 2.2e-30 104.2 1.1 3.9e-30 103.4 1.1 1.4 1 0 0 1 1 1 1 DNL zinc finger Ion_trans PF00520.29 001080672.1_16126001_1 - 1.3e-06 27.7 9.4 1.3e-06 27.7 9.4 1.8 2 0 0 2 2 2 1 Ion transport protein MAP65_ASE1 PF03999.10 200234.1_16125001_2 - 2.4e-159 531.7 33.5 3.1e-159 531.3 33.5 1.1 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) TilS_C PF11734.6 200234.1_16125001_2 - 0.062 12.6 0.4 2 7.8 0.0 2.8 2 0 0 2 2 2 0 TilS substrate C-terminal domain DUF4407 PF14362.4 200234.1_16125001_2 - 0.23 10.6 0.0 0.23 10.6 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) HLH PF00010.24 131080.1_16122001_3 - 1.7e-14 53.4 6.3 3.1e-14 52.6 6.3 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.11 131080.1_16122001_3 - 4.7e-05 23.4 0.2 0.00036 20.5 0.0 2.4 2 0 0 2 2 2 1 Hairy Orange Cytochrom_B562 PF07361.9 131080.1_16122001_3 - 0.078 13.5 0.4 0.4 11.2 0.6 1.9 1 1 1 2 2 2 0 Cytochrome b562 UNC-50 PF05216.11 200247.1_16123001_3 - 3.6e-88 294.7 20.8 4.4e-88 294.4 20.8 1.1 1 0 0 1 1 1 1 UNC-50 family MITF_TFEB_C_3_N PF15951.3 001257192.1_16123001_1 - 4.5e-67 225.3 16.1 4.5e-67 225.3 16.1 2.1 2 0 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus DUF3371 PF11851.6 001257192.1_16123001_1 - 1.5e-36 126.1 6.1 1.5e-36 126.1 6.1 3.6 2 1 0 2 2 2 1 Domain of unknown function (DUF3371) HLH PF00010.24 001257192.1_16123001_1 - 3.6e-16 58.7 0.6 6.9e-16 57.8 0.6 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Homeobox PF00046.27 001110759.1_16122001_3 - 3.2e-18 65.2 6.9 5.3e-18 64.5 6.9 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001110759.1_16122001_3 - 0.013 15.2 1.7 0.029 14.1 1.7 1.6 1 0 0 1 1 1 0 Homeobox KN domain Homez PF11569.6 001110759.1_16122001_3 - 0.067 12.5 2.1 0.11 11.9 0.2 2.1 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez I-set PF07679.14 200376.1_16126001_2 - 3.8e-45 151.8 0.0 1e-16 60.6 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 200376.1_16126001_2 - 4e-40 136.2 0.0 3.5e-14 53.0 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 200376.1_16126001_2 - 5.4e-28 97.0 0.0 8.8e-12 45.1 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 200376.1_16126001_2 - 6.1e-27 93.5 0.0 3.1e-10 39.9 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 200376.1_16126001_2 - 1.8e-16 60.1 0.1 0.0013 18.8 0.0 5.1 3 2 2 5 5 5 4 Immunoglobulin V-set domain Ig_5 PF16681.3 200376.1_16126001_2 - 2.6e-07 30.8 0.0 0.034 14.4 0.0 3.2 3 0 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 200376.1_16126001_2 - 1.6e-05 24.7 0.5 0.042 13.8 0.0 3.5 3 1 1 4 4 4 2 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.6 200376.1_16126001_2 - 0.00067 19.7 0.0 3.2 7.9 0.0 3.3 3 0 0 3 3 3 1 Natural killer cell receptor 2B4 A2M_comp PF07678.12 001113629.1_16129001_3 - 3.9e-67 226.2 0.1 6.9e-67 225.4 0.1 1.4 1 0 0 1 1 1 1 A-macroglobulin complement component A2M_N_2 PF07703.12 001113629.1_16129001_3 - 4.8e-32 111.1 4.1 1.1e-27 96.9 0.2 4.6 4 0 0 4 4 4 2 Alpha-2-macroglobulin family N-terminal region A2M PF00207.20 001113629.1_16129001_3 - 4.2e-27 93.7 0.6 2.1e-26 91.5 0.1 2.6 3 0 0 3 3 3 1 Alpha-2-macroglobulin family A2M_recep PF07677.12 001113629.1_16129001_3 - 8.8e-23 80.8 0.1 2.5e-22 79.3 0.1 1.9 1 0 0 1 1 1 1 A-macroglobulin receptor Thiol-ester_cl PF10569.7 001113629.1_16129001_3 - 1.9e-14 52.9 2.1 8.6e-14 50.8 2.1 2.3 1 0 0 1 1 1 1 Alpha-macro-globulin thiol-ester bond-forming region A2M_N PF01835.17 001113629.1_16129001_3 - 1.2e-13 51.2 0.1 5.8e-13 49.0 0.0 2.3 2 0 0 2 2 2 1 MG2 domain Big_1 PF02369.14 001113629.1_16129001_3 - 0.019 14.8 0.0 0.019 14.8 0.0 3.5 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 1) SVA PF05326.9 001113629.1_16129001_3 - 0.097 12.5 0.0 0.32 10.9 0.0 1.9 1 0 0 1 1 1 0 Seminal vesicle autoantigen (SVA) NAD_kinase PF01513.19 001080002.1_16125001_1 - 6.5e-65 219.1 0.0 9.1e-65 218.6 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase Globin PF00042.20 001103130.1_16122001_1 - 2.5e-26 92.3 0.0 5.4e-26 91.2 0.0 1.5 2 0 0 2 2 2 1 Globin 7tm_1 PF00001.19 001102391.1_16123001_1 - 1e-53 182.2 21.3 1.5e-53 181.6 21.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001102391.1_16123001_1 - 0.00049 19.4 21.1 0.0016 17.8 19.9 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx CcmD PF04995.12 001102391.1_16123001_1 - 0.034 14.1 1.0 0.17 11.8 0.5 2.5 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) IFNGR1 PF07140.9 001102391.1_16123001_1 - 0.039 13.9 0.1 0.084 12.8 0.1 1.5 1 0 0 1 1 1 0 Interferon gamma receptor (IFNGR1) Gal_Lectin PF02140.16 001110119.1_16122001_2 - 2.8e-25 88.4 4.7 2.8e-25 88.4 4.7 1.6 2 0 0 2 2 2 1 Galactose binding lectin domain ANTH PF07651.14 001166205.2_16128001_3 - 2.9e-78 262.5 10.5 3.9e-76 255.5 0.2 2.3 2 0 0 2 2 2 2 ANTH domain I_LWEQ PF01608.15 001166205.2_16128001_3 - 2.6e-54 183.5 8.5 2.6e-54 183.5 8.5 5.3 3 2 2 5 5 5 1 I/LWEQ domain HIP1_clath_bdg PF16515.3 001166205.2_16128001_3 - 1.3e-27 96.1 19.2 1.3e-27 96.1 19.2 6.9 5 2 2 7 7 7 2 Clathrin-binding domain of Huntingtin-interacting protein 1 Thiolase_N PF00108.21 131370.2_16124001_3 - 4.1e-98 327.7 2.3 5.9e-98 327.2 2.3 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 131370.2_16124001_3 - 1.4e-51 173.2 0.2 2.6e-51 172.3 0.2 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.24 131370.2_16124001_3 - 0.017 14.6 1.5 0.15 11.5 1.4 2.5 1 1 1 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.8 131370.2_16124001_3 - 0.021 14.8 0.0 0.35 10.9 0.0 2.5 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal IGFBP PF00219.16 001166231.1_16123001_1 - 7.5e-07 29.6 20.1 7.5e-07 29.6 20.1 4.6 4 1 2 6 6 6 1 Insulin-like growth factor binding protein Cys_knot PF00007.20 001166231.1_16123001_1 - 4.3e-06 26.8 14.9 4.3e-06 26.8 14.9 3.4 2 1 1 3 3 3 1 Cystine-knot domain FMO-like PF00743.17 198910.1_16125001_2 - 8.4e-253 839.5 0.0 1e-252 839.1 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 198910.1_16125001_2 - 1.6e-18 66.9 0.0 1.4e-14 53.9 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 198910.1_16125001_2 - 2e-13 50.1 0.1 7.9e-11 41.5 0.0 3.2 4 0 0 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.12 198910.1_16125001_2 - 2e-12 46.8 0.0 6.9e-11 41.8 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 198910.1_16125001_2 - 1.4e-05 25.1 0.0 3.1e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.25 198910.1_16125001_2 - 0.00021 21.6 0.2 0.07 13.6 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 198910.1_16125001_2 - 0.0014 18.2 0.6 0.19 11.2 0.0 2.7 2 1 1 3 3 3 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.4 198910.1_16125001_2 - 0.02 14.8 2.1 0.59 10.0 0.1 3.2 3 1 0 3 3 3 0 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.17 198910.1_16125001_2 - 0.096 11.9 0.1 0.58 9.3 0.0 2.0 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.10 198910.1_16125001_2 - 0.13 11.7 0.1 6.4 6.2 0.1 2.3 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain DUF3247 PF11607.6 198910.1_16125001_2 - 0.15 11.8 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3247) Pkinase_Tyr PF07714.15 131415.1_16128001_3 - 1.6e-95 319.2 0.0 2.2e-95 318.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.17 131415.1_16128001_3 - 8.3e-55 185.4 0.0 1.3e-54 184.8 0.0 1.3 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.23 131415.1_16128001_3 - 4.3e-46 157.3 0.0 6.9e-46 156.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 131415.1_16128001_3 - 4.8e-27 94.0 0.4 2.8e-12 46.7 0.0 2.8 3 0 0 3 3 3 2 Fibronectin type III domain SAM_1 PF00536.28 131415.1_16128001_3 - 1.6e-18 66.7 0.0 3.2e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EphA2_TM PF14575.4 131415.1_16128001_3 - 3.7e-18 66.0 0.5 2.5e-16 60.1 0.0 2.4 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain SAM_2 PF07647.15 131415.1_16128001_3 - 2.3e-12 46.7 0.0 4.3e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pur_ac_phosph_N PF16656.3 131415.1_16128001_3 - 9e-06 26.0 0.1 0.0011 19.3 0.1 2.6 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Ephrin_rec_like PF07699.11 131415.1_16128001_3 - 0.0001 21.8 2.6 0.0001 21.8 2.6 2.5 3 0 0 3 3 3 1 Putative ephrin-receptor like Kdo PF06293.12 131415.1_16128001_3 - 0.0028 16.9 0.0 0.0048 16.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.14 131415.1_16128001_3 - 0.025 14.6 0.0 0.052 13.6 0.0 1.4 1 0 0 1 1 1 0 ABC1 family Sushi PF00084.18 131415.1_16128001_3 - 0.035 14.6 2.7 1.9 9.1 0.0 2.9 1 1 1 2 2 2 0 Sushi repeat (SCR repeat) Interfer-bind PF09294.8 131415.1_16128001_3 - 0.07 13.3 3.7 5.3 7.3 0.0 3.3 4 0 0 4 4 4 0 Interferon-alpha/beta receptor, fibronectin type III PP2C PF00481.19 131429.1_16124001_3 - 4e-85 285.4 0.0 5.3e-85 285.0 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_C PF07830.11 131429.1_16124001_3 - 1e-32 112.2 0.1 2.7e-32 110.9 0.1 1.7 2 0 0 2 2 2 1 Protein serine/threonine phosphatase 2C, C-terminal domain PP2C_2 PF13672.4 131429.1_16124001_3 - 0.046 13.2 0.0 0.1 12.1 0.0 1.5 1 1 0 1 1 1 0 Protein phosphatase 2C XTBD PF11952.6 001006055.1_16122001_2 - 9.8e-33 111.6 0.1 9.8e-33 111.6 0.1 2.3 2 0 0 2 2 2 1 XRN-Two Binding Domain, XTBD ECH_1 PF00378.18 001006068.1_16124001_1 - 9e-48 162.6 0.0 1.5e-47 161.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 001006068.1_16124001_1 - 1.2e-27 97.2 0.0 2.3e-26 93.0 0.0 1.9 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase SAM_1 PF00536.28 001128716.1_16124001_2 - 4.8e-14 52.4 0.2 3.2e-13 49.8 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 001128716.1_16124001_2 - 4e-07 29.9 0.4 1e-06 28.6 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DUF1674 PF07896.10 001030184.1_16122001_2 - 8.2e-20 70.9 4.8 1.5e-19 70.1 4.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1674) DUF2576 PF10845.6 001030184.1_16122001_2 - 0.021 14.3 0.1 0.042 13.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) Tetraspannin PF00335.18 131518.2_16128001_1 - 6.1e-42 143.7 14.6 1.3e-41 142.6 14.6 1.6 1 0 0 1 1 1 1 Tetraspanin family PGM_PMM_I PF02878.14 001007053.1_16126001_1 - 2.3e-18 66.1 0.1 3.4e-08 33.2 0.0 2.5 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.18 001007053.1_16126001_1 - 2.7e-13 49.8 0.4 7.7e-13 48.3 0.4 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.14 001007053.1_16126001_1 - 0.0022 18.0 0.5 0.0079 16.3 0.5 2.0 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III HTH_psq PF05225.14 001007053.1_16126001_1 - 0.026 14.1 1.8 0.22 11.1 0.1 2.9 3 0 0 3 3 3 0 helix-turn-helix, Psq domain Aerolysin PF01117.18 001110406.1_16123001_1 - 8.9e-05 21.7 5.3 0.00013 21.2 5.3 1.1 1 0 0 1 1 1 1 Aerolysin toxin ETX_MTX2 PF03318.11 001110406.1_16123001_1 - 0.0091 15.7 16.9 0.014 15.0 16.9 1.2 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Syntaxin PF00804.23 131523.1_16122001_1 - 7e-65 218.3 18.9 7e-65 218.3 18.9 1.3 2 0 0 2 2 1 1 Syntaxin SNARE PF05739.17 131523.1_16122001_1 - 5.6e-22 77.4 1.5 5.6e-22 77.4 1.5 2.5 3 0 0 3 3 2 1 SNARE domain Syntaxin_2 PF14523.4 131523.1_16122001_1 - 6.3e-10 39.2 8.1 6.3e-10 39.2 8.1 2.6 1 1 1 2 2 2 1 Syntaxin-like protein AAA_13 PF13166.4 131523.1_16122001_1 - 7.8e-05 21.4 16.2 9.6e-05 21.1 16.2 1.1 1 0 0 1 1 1 1 AAA domain Lzipper-MIP1 PF14389.4 131523.1_16122001_1 - 0.013 15.6 0.5 0.013 15.6 0.5 2.5 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 FAD_binding_1 PF00667.18 131523.1_16122001_1 - 0.046 13.1 1.0 0.094 12.1 1.0 1.5 1 0 0 1 1 1 0 FAD binding domain RE_NgoFVII PF09565.8 131523.1_16122001_1 - 0.052 12.7 8.9 0.02 14.1 6.3 1.6 1 1 0 1 1 1 0 NgoFVII restriction endonuclease DUF1910 PF08928.8 131523.1_16122001_1 - 0.068 13.0 13.7 0.32 10.9 1.6 3.4 1 1 3 4 4 4 0 Domain of unknown function (DUF1910) GNVR PF13807.4 131523.1_16122001_1 - 0.089 12.6 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase WXG100 PF06013.10 131523.1_16122001_1 - 0.11 12.5 6.1 5.4 7.2 1.0 4.1 3 1 1 4 4 4 0 Proteins of 100 residues with WXG Baculo_PEP_C PF04513.10 131523.1_16122001_1 - 0.12 12.3 3.8 0.6 10.0 0.3 2.6 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus GlutR_dimer PF00745.18 131523.1_16122001_1 - 0.15 12.4 12.4 1.3 9.4 1.5 3.2 2 1 1 4 4 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain MCPsignal PF00015.19 131523.1_16122001_1 - 0.21 11.2 12.3 1.2 8.8 2.2 2.4 1 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF948 PF06103.9 131523.1_16122001_1 - 0.4 10.8 8.1 2.9 8.1 1.1 4.0 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) TolA_bind_tri PF16331.3 131523.1_16122001_1 - 0.41 10.6 0.0 0.41 10.6 0.0 3.6 5 2 0 5 5 4 0 TolA binding protein trimerisation Sec34 PF04136.13 131523.1_16122001_1 - 1 9.1 13.0 0.71 9.6 5.3 3.2 1 1 1 3 3 3 0 Sec34-like family YtxH PF12732.5 131523.1_16122001_1 - 1.3 9.5 11.6 3.3 8.2 2.2 3.8 1 1 1 2 2 2 0 YtxH-like protein Syntaxin-6_N PF09177.9 131523.1_16122001_1 - 2.5 8.6 16.2 0.18 12.3 4.5 3.4 1 1 2 3 3 3 0 Syntaxin 6, N-terminal Uso1_p115_C PF04871.11 131523.1_16122001_1 - 4.5 7.5 23.6 0.36 11.1 8.1 3.2 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF1515 PF07439.9 131523.1_16122001_1 - 4.6 7.1 15.8 0.26 11.2 1.3 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF1515) Herpes_UL25 PF01499.14 131523.1_16122001_1 - 4.9 5.4 8.9 0.8 8.0 3.2 2.0 1 1 1 2 2 2 0 Herpesvirus UL25 family Wtap PF17098.3 131523.1_16122001_1 - 5.4 6.8 15.0 0.61 9.9 1.0 3.6 3 2 0 3 3 3 0 WTAP/Mum2p family Med9 PF07544.11 131523.1_16122001_1 - 5.6 7.0 10.5 3.2 7.8 3.2 3.5 2 2 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 V_ATPase_I PF01496.17 131523.1_16122001_1 - 6.4 4.4 18.5 5.3 4.7 4.5 2.0 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Laminin_II PF06009.10 131523.1_16122001_1 - 6.9 6.5 13.8 1.3 8.9 4.0 2.7 2 1 0 2 2 2 0 Laminin Domain II DUF848 PF05852.9 131523.1_16122001_1 - 7.8 6.5 16.9 0.24 11.4 4.8 3.0 1 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) DUF4162 PF13732.4 131523.1_16122001_1 - 8.3 7.1 8.2 2.3 8.9 0.7 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4162) HeLo PF14479.4 131523.1_16122001_1 - 8.7 6.0 11.7 1.7e+02 1.8 11.2 2.4 1 1 0 1 1 1 0 Prion-inhibition and propagation UPF0004 PF00919.18 200627.1_16125001_2 - 1.7e-21 76.0 0.0 3.7e-21 74.9 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.19 200627.1_16125001_2 - 2.1e-18 67.1 0.1 5e-18 65.9 0.1 1.7 2 0 0 2 2 2 1 Radical SAM superfamily TRAM PF01938.18 200627.1_16125001_2 - 0.00066 19.5 0.0 0.0013 18.5 0.0 1.6 1 0 0 1 1 1 1 TRAM domain GNAT_acetyltr_2 PF13718.4 200644.1_16127001_3 - 3.4e-98 327.4 0.1 1.6e-97 325.2 0.0 2.2 3 0 0 3 3 3 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.4 200644.1_16127001_3 - 2.2e-78 263.1 4.5 4e-78 262.2 4.5 1.5 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.12 200644.1_16127001_3 - 2e-64 216.6 0.0 6.2e-64 215.0 0.0 1.9 1 0 0 1 1 1 1 Helicase DUF1726 PF08351.9 200644.1_16127001_3 - 3.3e-34 116.6 0.1 8.6e-34 115.2 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) Acetyltransf_7 PF13508.5 200644.1_16127001_3 - 0.00025 21.3 0.0 0.0021 18.3 0.0 2.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.23 200644.1_16127001_3 - 0.0016 18.5 0.0 0.0042 17.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family AAA_22 PF13401.4 200644.1_16127001_3 - 0.0053 16.9 0.0 1.5 9.0 0.0 3.1 2 0 0 2 2 2 1 AAA domain Fzo_mitofusin PF04799.11 200647.1_16126001_2 - 4.5e-75 250.4 9.3 4.5e-75 250.4 9.3 2.7 2 0 0 2 2 2 1 fzo-like conserved region Dynamin_N PF00350.21 200647.1_16126001_2 - 4.1e-25 88.6 0.0 4.1e-25 88.6 0.0 2.7 3 1 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.21 200647.1_16126001_2 - 1.2e-08 34.9 0.1 6.5e-08 32.5 0.0 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase Apolipoprotein PF01442.16 200647.1_16126001_2 - 0.007 16.2 6.9 0.067 13.0 0.1 2.8 2 1 0 2 2 2 1 Apolipoprotein A1/A4/E domain Synaptobrevin PF00957.19 200647.1_16126001_2 - 0.015 14.9 1.0 0.015 14.9 1.0 3.2 4 0 0 4 4 4 0 Synaptobrevin ABC_tran PF00005.25 200647.1_16126001_2 - 0.1 13.0 1.8 1.6 9.1 0.0 3.1 3 0 0 3 3 3 0 ABC transporter CorA PF01544.16 200647.1_16126001_2 - 0.2 10.8 7.8 0.026 13.7 1.6 2.3 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Baculo_PEP_C PF04513.10 200647.1_16126001_2 - 3.9 7.4 10.6 12 5.8 1.1 2.9 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CHDCT2 PF08074.9 200647.1_16126001_2 - 8 6.5 11.2 0.64 10.0 0.5 3.3 3 1 0 3 3 3 0 CHDCT2 (NUC038) domain Rab5-bind PF09311.9 001130782.1_16124001_3 - 0.0018 17.6 11.5 0.0018 17.6 11.5 2.2 2 0 0 2 2 2 1 Rabaptin-like protein dCache_2 PF08269.9 001130782.1_16124001_3 - 0.086 11.9 4.4 0.14 11.2 4.4 1.4 1 0 0 1 1 1 0 Cache domain ACCA PF03255.12 001130782.1_16124001_3 - 0.22 11.3 4.8 0.64 9.8 4.5 2.0 1 1 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Fmp27_WPPW PF10359.7 001130782.1_16124001_3 - 0.37 9.5 9.0 0.079 11.7 5.7 1.6 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain LMBR1 PF04791.14 001130782.1_16124001_3 - 0.59 8.8 4.4 0.92 8.2 4.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein FUSC PF04632.10 001130782.1_16124001_3 - 1 7.7 5.2 1.4 7.3 5.2 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family bZIP_1 PF00170.19 001130782.1_16124001_3 - 1.8 8.6 8.2 0.58 10.2 0.6 2.9 1 1 1 2 2 2 0 bZIP transcription factor Glyco_transf_8 PF01501.18 001007338.1_16123001_2 - 6.4e-54 183.1 0.0 8.2e-54 182.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 DicB PF05358.9 200682.2_16128001_1 - 0.2 11.7 2.1 0.43 10.6 2.1 1.5 1 0 0 1 1 1 0 DicB protein RRM_1 PF00076.20 200682.2_16128001_2 - 0.00038 20.1 0.1 1.3 8.7 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF_4EBP PF05456.9 001007354.2_16122001_2 - 2.5e-37 127.2 0.3 4.8e-37 126.3 0.3 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Peptidase_C1 PF00112.21 001105115.1_16123001_2 - 2.7e-84 282.5 1.0 4.6e-84 281.8 1.0 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 001105115.1_16123001_2 - 4.9e-18 65.2 4.6 9.1e-18 64.3 4.6 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 001105115.1_16123001_2 - 1.2e-06 27.5 2.4 0.00058 18.6 0.3 2.3 2 0 0 2 2 2 2 Peptidase C1-like family Cadherin PF00028.15 001008484.1_16127001_1 - 4.6e-86 283.3 9.5 1.9e-19 69.7 0.1 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001008484.1_16127001_1 - 2.6e-56 189.5 3.0 5.5e-56 188.4 3.0 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001008484.1_16127001_1 - 5.5e-35 118.9 1.1 8.9e-31 105.4 0.1 4.3 5 0 0 5 5 5 2 Cadherin-like Cadherin_C_2 PF16492.3 001008484.1_16127001_1 - 2.9e-12 47.1 2.2 6.1e-12 46.0 1.1 2.2 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001008484.1_16127001_1 - 2.6e-07 30.5 10.2 0.048 13.5 0.3 5.2 4 1 2 6 6 6 4 Cadherin-like TF_Otx PF03529.11 152940.1_16125001_3 - 2.4e-28 98.2 16.6 2.4e-28 98.2 16.6 2.9 2 1 1 3 3 3 1 Otx1 transcription factor Homeobox PF00046.27 152940.1_16125001_3 - 3e-21 74.8 2.8 5.2e-21 74.1 2.8 1.4 1 0 0 1 1 1 1 Homeobox domain FAD_binding_7 PF03441.12 131787.1_16124001_1 - 1e-67 227.3 0.6 1.8e-67 226.4 0.6 1.4 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.16 131787.1_16124001_1 - 1.6e-39 135.4 0.0 4.8e-39 133.8 0.0 1.7 2 0 0 2 2 2 1 DNA photolyase ETRAMP PF09716.8 001089409.1_16128001_1 - 0.041 13.8 5.7 0.081 12.9 5.7 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) E_Pc_C PF06752.10 001089409.1_16128001_2 - 1.3e-84 283.7 18.0 1.3e-84 283.7 18.0 1.7 2 0 0 2 2 2 1 Enhancer of Polycomb C-terminus EPL1 PF10513.7 001089409.1_16128001_2 - 2e-10 41.1 0.2 2e-10 41.1 0.2 3.4 4 0 0 4 4 4 1 Enhancer of polycomb-like C2 PF00168.28 001082929.1_16122001_2 - 1.6e-11 44.3 0.0 2.3e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 C2 domain Crystall PF00030.17 001007783.1_16122001_3 - 1.3e-53 179.0 10.3 2.6e-27 94.7 1.0 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 001007783.1_16122001_3 - 0.0038 17.0 6.0 0.26 11.1 1.1 3.3 1 1 2 3 3 3 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 001007783.1_16122001_3 - 0.0088 16.1 1.5 3.6 7.7 0.1 2.7 1 1 2 3 3 3 2 Beta/Gamma crystallin Ig_3 PF13927.4 001113794.1_16127001_1 - 1.9e-92 303.8 48.5 6.9e-11 42.5 0.3 11.7 11 0 0 11 11 11 11 Immunoglobulin domain Ig_2 PF13895.4 001113794.1_16127001_1 - 1.5e-76 252.6 47.6 1.2e-10 41.4 0.2 11.2 11 0 0 11 11 11 10 Immunoglobulin domain I-set PF07679.14 001113794.1_16127001_1 - 1.3e-73 242.9 20.6 7.9e-11 41.7 0.5 14.5 11 4 0 11 11 11 9 Immunoglobulin I-set domain ig PF00047.23 001113794.1_16127001_1 - 3e-45 152.2 55.0 1.6e-06 28.0 0.9 15.5 11 6 0 11 11 11 10 Immunoglobulin domain V-set PF07686.15 001113794.1_16127001_1 - 2.1e-26 92.1 46.7 0.0045 17.0 1.2 16.3 12 5 3 16 16 16 6 Immunoglobulin V-set domain Ig_5 PF16681.3 001113794.1_16127001_1 - 3.7e-21 75.2 2.8 0.04 14.2 0.0 9.5 9 0 0 9 9 9 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 001113794.1_16127001_1 - 6.1e-12 45.6 7.9 1.1 9.6 0.1 8.8 9 0 0 9 9 9 3 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 001113794.1_16127001_1 - 6.6e-11 42.0 0.1 0.44 10.5 0.0 6.8 9 0 0 9 9 9 3 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 001113794.1_16127001_1 - 2.3e-10 40.3 15.7 0.092 12.7 0.0 9.5 11 0 0 11 11 11 3 CD80-like C2-set immunoglobulin domain C2-set PF05790.13 001113794.1_16127001_1 - 3.7e-10 39.7 0.7 0.97 9.5 0.0 7.9 9 0 0 9 9 8 3 Immunoglobulin C2-set domain BiPBP_C PF06832.10 001113794.1_16127001_1 - 2.5e-09 36.9 0.0 4 7.4 0.0 8.0 9 1 1 10 10 10 1 Penicillin-Binding Protein C-terminus Family PKD_3 PF16820.3 001113794.1_16127001_1 - 1.5e-08 34.2 0.5 1.2 8.8 0.0 6.7 6 0 0 6 6 6 2 PKD-like domain Receptor_2B4 PF11465.6 001113794.1_16127001_1 - 0.00027 21.0 11.9 5.4 7.1 0.1 6.6 6 1 0 6 6 6 1 Natural killer cell receptor 2B4 3-alpha PF03475.12 001082939.2_16122001_2 - 0.026 14.2 0.2 0.053 13.3 0.2 1.5 1 0 0 1 1 1 0 3-alpha domain Crystall PF00030.17 001082939.2_16122001_3 - 1.5e-51 172.4 14.1 3.8e-26 91.0 4.3 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 001082939.2_16122001_3 - 0.00012 21.8 7.9 0.043 13.6 1.5 3.2 2 2 1 3 3 3 3 Peptidase inhibitor family I36 Crystall_3 PF08964.8 001082939.2_16122001_3 - 0.013 15.5 3.6 0.48 10.5 0.1 3.2 2 1 1 3 3 3 0 Beta/Gamma crystallin Cpn60_TCP1 PF00118.22 201290.1_16124001_2 - 7.3e-167 555.8 8.2 8.4e-167 555.6 8.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Crystall PF00030.17 001100442.1_16122001_1 - 1.6e-53 178.7 14.1 1.2e-27 95.7 4.2 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 001100442.1_16122001_1 - 0.00038 20.2 9.7 0.25 11.2 2.3 3.6 1 1 2 3 3 3 3 Peptidase inhibitor family I36 PMR5N PF14416.4 001100442.1_16122001_1 - 0.0078 16.3 3.5 0.35 11.1 0.2 3.5 3 0 0 3 3 3 1 PMR5 N terminal Domain Crystall_3 PF08964.8 001100442.1_16122001_1 - 0.091 12.8 4.8 1.1 9.4 0.1 3.0 1 1 1 3 3 3 0 Beta/Gamma crystallin PhzC-PhzF PF02567.14 001024411.1_16123001_3 - 6.5e-66 222.5 0.0 7.4e-66 222.4 0.0 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein RsmJ PF04378.11 001024411.1_16123001_3 - 0.036 13.2 0.0 0.061 12.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA large subunit methyltransferase D, RlmJ DAP_epimerase PF01678.17 001024411.1_16123001_3 - 0.068 13.2 0.0 11 6.1 0.0 2.3 2 1 0 2 2 2 0 Diaminopimelate epimerase CNH PF00780.20 001045125.2_16129001_2 - 9.4e-65 218.8 0.0 1.8e-64 217.9 0.0 1.5 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.23 001045125.2_16129001_2 - 6e-57 192.9 0.0 1.8e-56 191.3 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain KELK PF15796.3 001045125.2_16129001_2 - 2e-31 108.2 22.8 2e-31 108.2 22.8 7.5 6 1 1 7 7 5 2 KELK-motif containing domain of MRCK Ser/Thr protein kinase Pkinase_Tyr PF07714.15 001045125.2_16129001_2 - 2.5e-30 105.5 0.1 6.7e-30 104.1 0.1 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase DMPK_coil PF08826.8 001045125.2_16129001_2 - 1.4e-28 98.6 13.2 1.4e-28 98.6 13.2 8.8 6 2 5 11 11 10 1 DMPK coiled coil domain like C1_1 PF00130.20 001045125.2_16129001_2 - 2.2e-10 40.1 7.0 4.8e-10 39.0 7.0 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.4 001045125.2_16129001_2 - 4.1e-06 26.2 0.0 4.1e-06 26.2 0.0 2.2 2 1 0 2 2 1 1 Kinase-like PH PF00169.27 001045125.2_16129001_2 - 2.7e-05 24.5 0.4 0.00019 21.7 0.0 2.6 3 0 0 3 3 2 1 PH domain Pkinase_C PF00433.22 001045125.2_16129001_2 - 0.0027 18.2 1.2 0.012 16.2 1.2 2.2 1 0 0 1 1 1 1 Protein kinase C terminal domain C1_2 PF03107.14 001045125.2_16129001_2 - 0.0041 17.3 5.0 0.0097 16.1 5.0 1.6 1 0 0 1 1 1 1 C1 domain PBD PF00786.26 001045125.2_16129001_2 - 0.0079 16.5 1.7 0.02 15.1 0.1 2.7 3 0 0 3 3 2 1 P21-Rho-binding domain Myosin_tail_1 PF01576.17 001045125.2_16129001_2 - 0.011 13.4 106.5 0.011 13.4 78.3 2.7 1 1 1 2 2 2 0 Myosin tail Seadorna_VP7 PF07387.9 001045125.2_16129001_2 - 0.11 11.4 0.2 0.25 10.2 0.2 1.5 1 0 0 1 1 1 0 Seadornavirus VP7 HsbA PF12296.6 001045125.2_16129001_2 - 0.12 12.7 4.0 0.35 11.2 0.6 3.1 2 1 0 2 2 2 0 Hydrophobic surface binding protein A Reo_sigmaC PF04582.10 001045125.2_16129001_2 - 1 8.5 21.5 1.2 8.3 1.3 4.1 2 2 2 4 4 4 0 Reovirus sigma C capsid protein Tetraspannin PF00335.18 201014.1_16124001_2 - 2.7e-25 89.3 1.1 3.4e-25 89.0 1.1 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF1218 PF06749.10 201014.1_16124001_2 - 0.043 14.2 1.8 2.9 8.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) APP_E2 PF12925.5 152886.1_16129001_3 - 9.9e-69 230.7 15.1 1.5e-68 230.1 15.1 1.3 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.14 152886.1_16129001_3 - 2.3e-43 146.5 0.5 5.4e-43 145.3 0.5 1.7 1 0 0 1 1 1 1 Amyloid A4 N-terminal heparin-binding APP_Cu_bd PF12924.5 152886.1_16129001_3 - 7e-27 93.8 6.7 2.8e-26 91.9 3.9 2.9 2 0 0 2 2 2 1 Copper-binding of amyloid precursor, CuBD Beta-APP PF03494.11 152886.1_16129001_3 - 1e-25 89.2 1.4 1.7e-25 88.4 1.4 1.4 1 0 0 1 1 1 1 Beta-amyloid peptide (beta-APP) APP_amyloid PF10515.7 152886.1_16129001_3 - 1.1e-25 89.7 0.2 5.6e-25 87.5 0.2 2.3 1 0 0 1 1 1 1 beta-amyloid precursor protein C-terminus PilJ PF13675.4 152886.1_16129001_3 - 1.8 8.5 6.9 0.23 11.4 0.5 2.5 2 1 1 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Pkinase PF00069.23 001008646.1_16127001_1 - 3e-67 226.6 0.0 4.5e-67 226.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001008646.1_16127001_1 - 4.2e-29 101.5 0.0 6.9e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001008646.1_16127001_1 - 5.1e-05 22.6 0.5 0.0035 16.6 0.1 2.4 1 1 0 2 2 2 2 Kinase-like WD40 PF00400.30 201039.1_16125001_3 - 3.6e-39 131.9 22.2 7.2e-07 29.7 0.1 11.0 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 201039.1_16125001_3 - 5.7e-20 71.3 0.1 0.0084 16.3 0.0 7.7 3 3 4 8 8 8 7 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 201039.1_16125001_3 - 3.4e-08 33.5 0.1 0.88 9.3 0.0 5.2 2 1 3 5 5 5 4 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 201039.1_16125001_3 - 4.2e-05 22.5 4.5 2.9 6.6 0.0 5.6 4 3 3 7 7 7 2 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.10 201039.1_16125001_3 - 0.017 13.0 0.0 5.1 4.8 0.0 3.1 2 2 1 3 3 3 0 IKI3 family PD40 PF07676.10 201039.1_16125001_3 - 0.021 14.6 0.8 39 4.2 0.0 4.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat PQQ PF01011.19 201039.1_16125001_3 - 0.18 11.6 0.8 1 9.3 0.0 2.7 3 0 0 3 3 3 0 PQQ enzyme repeat PQQ_3 PF13570.4 201039.1_16125001_3 - 0.54 10.7 2.4 49 4.5 0.3 3.7 3 0 0 3 3 3 0 PQQ-like domain PI-PLC-X PF00388.17 001122773.1_16128001_1 - 9.5e-59 197.0 0.0 9.5e-59 197.0 0.0 2.8 3 0 0 3 3 3 1 Phosphatidylinositol-specific phospholipase C, X domain PLC-beta_C PF08703.8 001122773.1_16128001_1 - 3.1e-54 183.5 36.2 3.1e-54 183.5 36.2 2.8 3 0 0 3 3 3 2 PLC-beta C terminal PI-PLC-Y PF00387.17 001122773.1_16128001_1 - 4.5e-43 146.1 0.7 4.5e-43 146.1 0.7 2.8 3 1 0 3 3 3 1 Phosphatidylinositol-specific phospholipase C, Y domain DUF1154 PF06631.9 001122773.1_16128001_1 - 1.9e-06 27.6 8.5 1.9e-06 27.6 8.5 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF1154) EF-hand_like PF09279.9 001122773.1_16128001_1 - 2.3e-06 27.9 0.0 2.3e-06 27.9 0.0 3.2 3 0 0 3 3 3 1 Phosphoinositide-specific phospholipase C, efhand-like Rhodanese PF00581.18 001122773.1_16128001_1 - 0.084 13.3 0.3 0.31 11.4 0.3 2.0 1 0 0 1 1 1 0 Rhodanese-like domain Cpn60_TCP1 PF00118.22 201455.1_16124001_2 - 9.2e-146 486.2 12.1 1.1e-145 486.0 12.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF2529 PF10740.7 201455.1_16124001_2 - 0.013 15.0 0.2 0.039 13.4 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2529) Ribosomal_S13 PF00416.20 201455.1_16124001_2 - 0.11 12.7 0.8 0.6 10.4 0.2 2.4 2 0 0 2 2 2 0 Ribosomal protein S13/S18 FTCD_N PF07837.10 201077.2_16124001_1 - 2.8e-72 242.1 0.0 4.4e-72 241.4 0.0 1.3 1 0 0 1 1 1 1 Formiminotransferase domain, N-terminal subdomain FTCD PF02971.12 201077.2_16124001_1 - 7e-69 230.5 0.0 3.6e-68 228.1 0.0 2.0 2 0 0 2 2 2 1 Formiminotransferase domain FTCD_C PF04961.10 201077.2_16124001_1 - 2.3e-68 229.4 1.7 4.5e-68 228.4 1.7 1.5 1 0 0 1 1 1 1 Formiminotransferase-cyclodeaminase zf-SNAP50_C PF12251.6 201115.2_16123001_3 - 4.6e-72 241.8 7.9 7.7e-72 241.0 7.9 1.4 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal Ras PF00071.20 001013478.1_16123001_1 - 3.2e-51 173.0 0.0 5.1e-51 172.4 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001013478.1_16123001_1 - 2.6e-28 98.5 0.0 6.8e-28 97.2 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001013478.1_16123001_1 - 7.3e-07 28.7 0.0 1.3e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001013478.1_16123001_1 - 5.7e-05 23.0 0.0 0.00033 20.6 0.0 2.1 1 1 1 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.14 001013478.1_16123001_1 - 0.00015 21.6 0.0 0.063 13.0 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 001013478.1_16123001_1 - 0.0012 18.2 0.0 0.0018 17.5 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.15 001013478.1_16123001_1 - 0.01 15.4 0.1 2.5 7.7 0.0 2.3 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein BIR PF00653.19 145195.1_16121001_3 - 2.7e-23 82.3 5.1 4.5e-23 81.6 5.1 1.4 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain FAM53 PF15242.4 001111239.1_16126001_3 - 7.1e-57 193.4 34.4 1.3e-56 192.5 34.4 1.5 1 0 0 1 1 1 1 Family of FAM53 DNA_pol3_delta2 PF13177.4 201457.1_16123001_2 - 5.6e-13 48.8 0.4 1.1e-12 47.9 0.4 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.13 201457.1_16123001_2 - 1e-07 31.2 0.2 1.4e-07 30.7 0.2 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA PF00004.27 201457.1_16123001_2 - 3.7e-06 27.3 0.0 8.2e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 201457.1_16123001_2 - 0.001 19.2 0.2 0.0051 17.0 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.4 201457.1_16123001_2 - 0.0031 17.8 0.3 0.013 15.8 0.1 2.1 2 1 0 2 2 2 1 AAA ATPase domain DNA_pol3_delta PF06144.11 201457.1_16123001_2 - 0.012 15.3 0.0 0.029 14.0 0.0 1.6 1 1 0 1 1 1 0 DNA polymerase III, delta subunit ABC_tran PF00005.25 201457.1_16123001_2 - 0.052 13.9 0.0 0.093 13.1 0.0 1.4 1 0 0 1 1 1 0 ABC transporter DUF2247 PF10004.7 201457.1_16123001_2 - 0.053 13.2 0.1 0.097 12.3 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2247) Rep_fac_C PF08542.9 201457.1_16123001_2 - 0.055 13.7 0.6 0.11 12.8 0.1 1.8 2 0 0 2 2 2 0 Replication factor C C-terminal domain AAA_5 PF07728.12 201457.1_16123001_2 - 0.1 12.4 0.6 0.23 11.3 0.6 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_11 PF13086.4 201457.1_16123001_2 - 0.12 12.0 2.0 0.61 9.6 1.4 1.9 1 1 0 1 1 1 0 AAA domain FGF PF00167.16 001012380.1_16122001_1 - 1.6e-41 141.2 0.1 2.2e-41 140.7 0.1 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Joubert PF15392.4 001012380.1_16122001_3 - 0.011 15.3 0.8 0.014 15.0 0.8 1.1 1 0 0 1 1 1 0 Joubert syndrome-associated Methyltransf_2 PF00891.16 001110477.1_16124001_1 - 4.4e-70 235.3 0.0 6e-70 234.9 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Dimerisation2 PF16864.3 001110477.1_16124001_1 - 1.2e-29 101.9 0.1 2.1e-29 101.2 0.1 1.4 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_25 PF13649.4 001110477.1_16124001_1 - 1.5e-07 31.9 0.0 2.8e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001110477.1_16124001_1 - 2.3e-05 24.1 0.0 3.9e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001110477.1_16124001_1 - 4.6e-05 23.2 0.0 7.3e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001110477.1_16124001_1 - 0.00016 22.1 0.0 0.00028 21.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Dimerisation PF08100.9 001110477.1_16124001_1 - 0.00028 20.7 0.0 0.00064 19.6 0.0 1.6 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_12 PF08242.10 001110477.1_16124001_1 - 0.00049 20.6 0.0 0.0013 19.3 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.12 001110477.1_16124001_1 - 0.012 15.0 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain TrmB PF01978.17 001110477.1_16124001_1 - 0.021 14.5 0.0 0.045 13.5 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.5 001110477.1_16124001_1 - 0.084 12.8 0.0 0.45 10.5 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain FeoC PF09012.8 001110477.1_16124001_1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator HTH_11 PF08279.10 001110477.1_16124001_1 - 0.15 11.9 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 HTH domain Metallophos PF00149.26 001004527.3_16125001_3 - 2e-38 132.8 0.1 2.6e-38 132.4 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 001004527.3_16125001_3 - 4e-20 71.8 0.6 8.5e-20 70.8 0.6 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain TH1 PF04858.11 201190.1_16125001_2 - 1.2e-275 915.6 0.1 1.4e-275 915.3 0.1 1.0 1 0 0 1 1 1 1 TH1 protein Aconitase PF00330.18 001034983.1_16126001_1 - 5.5e-181 602.4 0.0 7e-181 602.1 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.17 001034983.1_16126001_1 - 6.9e-47 158.9 0.0 3.6e-46 156.6 0.0 2.0 2 0 0 2 2 2 1 Aconitase C-terminal domain 7tm_1 PF00001.19 001270478.1_16123001_1 - 3.3e-57 193.6 25.5 5.1e-57 193.0 25.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001270478.1_16123001_1 - 1e-07 31.5 25.1 1.3e-07 31.1 25.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001270478.1_16123001_1 - 0.00013 21.7 26.4 0.0021 17.7 26.4 2.4 1 1 0 1 1 1 1 Olfactory receptor DUF872 PF05915.10 001270478.1_16123001_1 - 0.59 10.3 4.1 2 8.5 0.1 2.9 3 1 0 3 3 3 0 Eukaryotic protein of unknown function (DUF872) Guanylin PF02058.13 001311211.1_16121001_1 - 2.2e-27 95.2 1.2 2.7e-27 94.9 1.2 1.1 1 0 0 1 1 1 1 Guanylin precursor LAT PF15234.4 001311211.1_16121001_1 - 0.004 16.8 0.3 0.0045 16.7 0.3 1.1 1 0 0 1 1 1 1 Linker for activation of T-cells Aa_trans PF01490.16 001144815.1_16123001_1 - 3.6e-52 177.3 35.6 4.2e-52 177.1 35.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.4 001144815.1_16123001_1 - 1.4e-09 37.2 38.5 1.9e-09 36.8 38.5 1.1 1 0 0 1 1 1 1 Amino acid permease Trp_Tyr_perm PF03222.11 001144815.1_16123001_1 - 0.00045 19.2 31.5 0.0073 15.2 31.5 2.4 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family MHC2-interact PF09307.8 001144815.1_16123001_1 - 0.075 12.9 1.5 6.8 6.6 0.0 3.1 3 0 0 3 3 3 0 CLIP, MHC2 interacting PNP_UDP_1 PF01048.18 001013301.1_16122001_2 - 1e-14 54.2 0.0 1.3e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Synaphin PF05835.10 001171591.1_16121001_1 - 8.8e-40 136.1 11.1 1.2e-39 135.7 11.1 1.2 1 0 0 1 1 1 1 Synaphin protein RSRP PF17069.3 001171591.1_16121001_1 - 0.14 11.6 1.0 0.14 11.5 1.0 1.1 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 LPP PF04728.11 001171591.1_16121001_1 - 0.52 10.6 4.1 18 5.7 0.5 2.6 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Cytidylate_kin2 PF13189.4 001171591.1_16121001_1 - 0.95 9.5 5.1 0.7 9.9 0.7 2.0 1 1 1 2 2 2 0 Cytidylate kinase-like family FeoB_C PF07664.10 001171591.1_16121001_2 - 0.47 10.0 2.2 0.8 9.3 2.2 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B C terminus MBD_C PF14048.4 212580.1_16124001_1 - 1.9e-33 114.9 0.0 3.6e-33 114.0 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of methyl-CpG binding protein 2 and 3 MBDa PF16564.3 212580.1_16124001_1 - 6.3e-29 99.8 1.5 1.1e-28 99.1 1.5 1.4 1 0 0 1 1 1 1 p55-binding region of Methyl-CpG-binding domain proteins MBD MBD PF01429.17 212580.1_16124001_1 - 4.6e-07 29.3 0.9 0.0002 20.9 0.0 2.4 1 1 0 2 2 2 2 Methyl-CpG binding domain Gpi1 PF05024.13 199429.1_16126001_2 - 4e-66 222.6 9.7 8.1e-66 221.6 9.7 1.5 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) OAD_gamma PF04277.11 199429.1_16126001_2 - 1.9 9.0 4.7 5 7.6 4.7 1.7 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain NAP PF00956.16 201468.1_16124001_2 - 6.4e-36 123.8 11.7 5.5e-33 114.2 2.8 2.8 2 1 1 3 3 3 2 Nucleosome assembly protein (NAP) Phage_Mu_Gam PF07352.10 201468.1_16124001_2 - 0.013 15.3 2.6 0.022 14.5 2.6 1.3 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Dynamin_N PF00350.21 201468.1_16124001_2 - 0.8 9.6 4.8 0.14 12.1 0.5 1.8 2 0 0 2 2 2 0 Dynamin family PNK3P PF08645.9 001077578.2_16125001_3 - 2.9e-54 182.9 0.0 4.5e-54 182.3 0.0 1.3 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.4 001077578.2_16125001_3 - 2.3e-12 47.1 0.1 1.3e-09 38.2 0.1 2.5 1 1 0 1 1 1 1 AAA domain Hydrolase_6 PF13344.4 001077578.2_16125001_3 - 0.018 15.0 0.0 0.096 12.7 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase TMEM151 PF14857.4 001103144.1_16126001_1 - 7e-209 693.9 14.2 8.5e-209 693.6 14.2 1.0 1 0 0 1 1 1 1 TMEM151 family Pkinase PF00069.23 205699.1_16127001_2 - 1.1e-68 231.3 0.0 1.1e-68 231.3 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain PH_3 PF14593.4 205699.1_16127001_2 - 3.4e-43 145.8 0.0 9.7e-43 144.4 0.0 1.8 1 0 0 1 1 1 1 PH domain Pkinase_Tyr PF07714.15 205699.1_16127001_2 - 3e-37 128.2 0.0 4.9e-37 127.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 205699.1_16127001_2 - 7e-07 28.7 0.0 5.9e-06 25.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.21 205699.1_16127001_2 - 0.0035 17.2 0.0 0.081 12.7 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.12 205699.1_16127001_2 - 0.0066 15.7 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family G0-G1_switch_2 PF15103.4 205699.1_16127001_3 - 0.026 14.8 3.8 0.047 14.0 3.8 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 Mito_carr PF00153.25 205715.1_16124001_2 - 3.5e-64 212.6 0.4 5.1e-21 74.3 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Sec3_C PF09763.7 199597.1_16127001_2 - 1.5e-196 654.9 27.4 1.9e-196 654.4 27.4 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.4 199597.1_16127001_2 - 6.3e-28 96.6 2.5 1.6e-27 95.3 2.5 1.8 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH FlaC_arch PF05377.9 199597.1_16127001_2 - 0.34 11.2 3.7 2.6 8.4 1.2 3.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF310 PF03750.11 199597.1_16127001_2 - 1.4 9.7 10.1 0.082 13.6 1.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF310) FlgN PF05130.10 199597.1_16127001_2 - 2 8.8 13.0 2 8.8 8.3 3.2 2 1 0 2 2 2 0 FlgN protein Actin PF00022.17 001002066.1_16123001_3 - 3.5e-150 500.0 0.0 1e-149 498.5 0.0 1.6 1 1 0 1 1 1 1 Actin Ldl_recept_a PF00057.16 001130607.1_16124001_2 - 6.6e-30 102.9 48.5 2.5e-11 43.5 9.7 3.9 4 0 0 4 4 4 3 Low-density lipoprotein receptor domain class A PspB PF06667.10 001130607.1_16124001_2 - 0.24 11.3 0.5 0.47 10.4 0.5 1.4 1 0 0 1 1 1 0 Phage shock protein B TRAM_LAG1_CLN8 PF03798.14 199637.1_16123001_2 - 4.4e-44 150.5 16.9 5.4e-44 150.2 16.9 1.1 1 0 0 1 1 1 1 TLC domain DC_STAMP PF07782.11 001014340.1_16124001_3 - 4.2e-34 117.9 0.4 4.2e-34 117.9 0.4 3.0 2 1 0 2 2 2 1 DC-STAMP-like protein P_C10 PF14974.4 212646.1_16123001_2 - 1.6e-38 130.8 0.3 2.3e-38 130.3 0.3 1.2 1 0 0 1 1 1 1 Protein C10 zf-H2C2_2 PF13465.4 001014362.1_16124001_1 - 1.5e-73 240.1 71.6 5.4e-09 36.0 1.4 12.0 12 0 0 12 12 12 9 Zinc-finger double domain zf-C2H2 PF00096.24 001014362.1_16124001_1 - 7.6e-53 174.0 85.2 1.7e-07 31.2 0.7 11.3 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001014362.1_16124001_1 - 2.4e-40 133.5 78.7 0.00035 21.0 0.4 11.4 11 0 0 11 11 11 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001014362.1_16124001_1 - 8e-19 67.0 68.9 0.0011 18.7 0.3 11.5 10 1 0 11 11 11 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001014362.1_16124001_1 - 2.6e-12 46.6 47.7 0.27 11.5 0.3 11.2 11 0 0 11 11 11 4 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 001014362.1_16124001_1 - 4.5e-12 45.4 63.9 0.054 13.1 0.4 11.0 11 0 0 11 11 11 7 zinc-finger C2H2-type zf-LYAR PF08790.9 001014362.1_16124001_1 - 5.8e-08 32.4 52.9 0.039 13.7 0.8 10.5 10 0 0 10 10 10 4 LYAR-type C2HC zinc finger Zn-ribbon_8 PF09723.8 001014362.1_16124001_1 - 1.4e-07 31.4 41.6 0.005 16.8 1.4 8.0 1 1 8 9 9 9 5 Zinc ribbon domain zf-C2HE PF16278.3 001014362.1_16124001_1 - 8.7e-07 29.2 57.9 0.87 10.0 0.3 10.2 3 3 6 9 9 9 5 C2HE / C2H2 / C2HC zinc-binding finger ADK_lid PF05191.12 001014362.1_16124001_1 - 5.8e-05 22.9 32.2 0.28 11.1 0.5 7.4 4 3 3 7 7 7 3 Adenylate kinase, active site lid HypA PF01155.17 001014362.1_16124001_1 - 0.00022 21.1 31.3 0.3 11.0 0.4 5.8 1 1 4 5 5 5 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-trcl PF13451.4 001014362.1_16124001_1 - 0.00035 20.3 34.6 1.9 8.3 0.1 9.4 9 1 0 9 9 9 1 Probable zinc-ribbon domain zinc_ribbon_15 PF17032.3 001014362.1_16124001_1 - 0.00065 20.3 39.0 0.52 11.0 1.8 6.3 1 1 9 10 10 10 6 zinc-ribbon family zf-AN1 PF01428.14 001014362.1_16124001_1 - 0.0033 17.4 44.7 12 6.1 0.1 10.7 11 0 0 11 11 11 0 AN1-like Zinc finger Zn_Tnp_IS1595 PF12760.5 001014362.1_16124001_1 - 0.006 16.4 48.3 0.23 11.3 1.1 7.4 5 1 1 7 7 7 3 Transposase zinc-ribbon domain zf-C2HC_2 PF13913.4 001014362.1_16124001_1 - 0.076 12.8 0.2 0.076 12.8 0.2 9.3 11 0 0 11 11 10 0 zinc-finger of a C2HC-type Siva PF05458.10 001014362.1_16124001_1 - 0.085 12.4 26.9 0.31 10.6 0.8 4.5 1 1 3 4 4 4 0 Cd27 binding protein (Siva) zf-met PF12874.5 001014362.1_16124001_1 - 0.11 12.7 74.2 0.19 12.0 0.9 11.1 11 0 0 11 11 11 0 Zinc-finger of C2H2 type LIM PF00412.20 001014362.1_16124001_1 - 0.17 12.0 45.3 1 9.5 0.7 8.5 2 2 4 8 8 8 0 LIM domain Rpr2 PF04032.14 001014362.1_16124001_1 - 0.83 9.9 36.9 4.6 7.5 0.1 6.2 4 1 1 5 5 5 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain GAGA PF09237.9 001014362.1_16124001_1 - 3.4 7.4 10.0 0.82 9.4 0.2 3.8 3 1 1 4 4 4 0 GAGA factor ROS_MUCR PF05443.9 001014362.1_16124001_1 - 3.6 7.5 8.4 4.2 7.3 0.2 4.1 2 1 2 4 4 4 0 ROS/MUCR transcriptional regulator protein XPA_N PF01286.16 001014362.1_16124001_1 - 3.6 7.6 39.0 12 5.9 0.3 9.8 10 0 0 10 10 10 0 XPA protein N-terminal BDHCT_assoc PF16204.3 001014362.1_16124001_1 - 6.7 6.2 12.0 32 4.0 0.3 4.1 2 1 2 4 4 4 0 BDHCT-box associated domain on Bloom syndrome protein ADK PF00406.20 001017540.2_16124001_1 - 2.5e-33 115.2 0.0 3.7e-33 114.6 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.4 001017540.2_16124001_1 - 1.3e-26 93.5 0.0 2.2e-26 92.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 001017540.2_16124001_1 - 9.2e-08 32.5 0.0 2.6e-07 31.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.4 001017540.2_16124001_1 - 1.7e-07 31.4 0.0 4.2e-07 30.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.15 001017540.2_16124001_1 - 0.00016 21.3 0.9 0.00039 20.0 0.9 1.7 1 1 0 1 1 1 1 Thymidylate kinase Zeta_toxin PF06414.10 001017540.2_16124001_1 - 0.0036 16.5 0.0 0.078 12.1 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin AAA_28 PF13521.4 001017540.2_16124001_1 - 0.015 15.4 0.0 0.039 14.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain Dpy-30 PF05186.11 001017540.2_16124001_1 - 0.016 14.8 0.0 0.026 14.1 0.0 1.4 1 0 0 1 1 1 0 Dpy-30 motif AAA_19 PF13245.4 001017540.2_16124001_1 - 0.1 12.8 0.0 0.24 11.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain TSGP1 PF07771.9 001114743.1_16127001_1 - 3.2 7.8 12.6 5.4 7.1 12.6 1.2 1 0 0 1 1 1 0 Tick salivary peptide group 1 Pkinase_Tyr PF07714.15 001114743.1_16127001_2 - 1.3e-81 273.6 0.1 2e-81 273.0 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001114743.1_16127001_2 - 8.9e-44 149.7 0.0 8.9e-44 149.7 0.0 1.6 2 0 0 2 2 1 1 Protein kinase domain SH2 PF00017.22 001114743.1_16127001_2 - 2.4e-17 62.6 0.1 8.4e-17 60.9 0.1 2.0 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001114743.1_16127001_2 - 2.4e-14 52.5 0.1 8.8e-14 50.7 0.0 2.0 2 0 0 2 2 2 1 SH3 domain PH PF00169.27 001114743.1_16127001_2 - 1.3e-13 51.2 0.7 1.3e-13 51.2 0.7 3.0 3 0 0 3 3 2 1 PH domain BTK PF00779.17 001114743.1_16127001_2 - 3e-11 42.8 2.8 6.8e-11 41.6 2.8 1.6 1 0 0 1 1 1 1 BTK motif SH3_9 PF14604.4 001114743.1_16127001_2 - 6.3e-07 29.0 0.1 1.3e-06 28.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001114743.1_16127001_2 - 2.8e-05 23.6 0.1 6.6e-05 22.4 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain hSH3 PF14603.4 001114743.1_16127001_2 - 0.0017 18.7 0.2 0.0086 16.5 0.0 2.2 2 0 0 2 2 2 1 Helically-extended SH3 domain SH3_3 PF08239.9 001114743.1_16127001_2 - 0.0046 17.1 0.4 0.011 15.9 0.4 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_4 PF06347.11 001114743.1_16127001_2 - 0.025 14.3 0.0 0.05 13.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain Pkinase_Tyr PF07714.15 001114743.1_16127001_3 - 5.1e-05 22.6 0.1 8.6e-05 21.8 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SID-1_RNA_chan PF13965.4 001089426.1_16123001_1 - 1.7 6.9 7.8 2.1 6.6 7.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Maf PF02545.12 213511.1_16125001_2 - 2.9e-53 180.0 0.0 5.6e-53 179.1 0.0 1.5 1 0 0 1 1 1 1 Maf-like protein Methyltransf_2 PF00891.16 213511.1_16125001_2 - 5.7e-53 179.3 0.0 1e-52 178.5 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Dimerisation2 PF16864.3 213511.1_16125001_2 - 7.1e-30 102.7 0.1 1.7e-29 101.5 0.1 1.7 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_25 PF13649.4 213511.1_16125001_2 - 0.00026 21.5 0.0 0.00088 19.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 213511.1_16125001_2 - 0.0064 17.1 0.0 0.015 15.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain TFIID-18kDa PF02269.14 001004665.1_16122001_2 - 1.6e-36 124.1 0.3 2.2e-36 123.6 0.3 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit I-set PF07679.14 001098769.2_16123001_3 - 3e-23 81.5 0.0 8.7e-16 57.6 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 001098769.2_16123001_3 - 1.5e-20 73.5 0.0 1.7e-12 47.6 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001098769.2_16123001_3 - 2.6e-11 43.6 0.0 4.8e-06 26.7 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001098769.2_16123001_3 - 1.3e-09 37.9 0.0 3.9e-05 23.6 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001098769.2_16123001_3 - 6.1e-06 26.2 0.0 0.13 12.3 0.0 3.2 2 1 1 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 001098769.2_16123001_3 - 6.7e-05 22.8 0.1 0.099 12.6 0.0 2.4 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Fcf1 PF04900.10 001017601.1_16123001_1 - 1.2e-39 134.6 1.9 2.9e-39 133.4 1.9 1.7 1 0 0 1 1 1 1 Fcf1 VCBS PF13517.4 207053.1_16128001_1 - 9e-05 22.9 0.7 2.7 8.5 0.0 3.8 3 1 1 4 4 4 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PQQ_2 PF13360.4 207053.1_16128001_1 - 0.00045 19.7 0.8 0.042 13.3 0.2 2.3 2 0 0 2 2 2 2 PQQ-like domain FG-GAP PF01839.21 207053.1_16128001_1 - 0.001 19.0 5.5 0.2 11.7 0.1 4.0 4 0 0 4 4 4 2 FG-GAP repeat AP3D1 PF06375.9 207053.1_16128001_1 - 3.6 7.7 16.0 6 7.0 16.0 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 BAR_3 PF16746.3 001102639.1_16123001_3 - 2e-95 318.9 12.9 2.5e-95 318.6 12.9 1.1 1 0 0 1 1 1 1 BAR domain of APPL family Fib_alpha PF08702.8 001102639.1_16123001_3 - 0.99 9.5 11.1 0.13 12.3 3.8 2.8 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family LIM PF00412.20 201198.1_16125001_2 - 3e-32 110.5 32.2 2.7e-13 49.8 5.4 3.3 3 0 0 3 3 3 3 LIM domain Mut7-C PF01927.14 201198.1_16125001_2 - 6.6 6.7 15.5 0.037 14.0 1.9 3.1 2 1 0 2 2 2 0 Mut7-C RNAse domain BTB PF00651.29 001079948.2_16126001_1 - 8.5e-27 93.5 0.4 1.4e-26 92.7 0.4 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_1 PF01344.23 001079948.2_16126001_1 - 1.3e-24 85.3 10.3 3e-05 23.4 0.0 6.6 6 0 0 6 6 6 5 Kelch motif BACK PF07707.13 001079948.2_16126001_1 - 9.9e-20 70.4 0.0 2.4e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.4 001079948.2_16126001_1 - 4.7e-15 55.3 4.2 0.00041 20.4 0.0 6.0 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.4 001079948.2_16126001_1 - 2.5e-13 49.6 6.8 0.26 11.5 0.0 6.3 5 1 1 6 6 6 5 Kelch motif Kelch_4 PF13418.4 001079948.2_16126001_1 - 9.2e-13 47.8 4.4 0.017 14.9 0.0 5.7 4 2 1 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.13 001079948.2_16126001_1 - 2.6e-07 30.2 7.3 0.017 14.9 0.1 5.9 6 0 0 6 6 6 2 Kelch motif Kelch_5 PF13854.4 001079948.2_16126001_1 - 0.01 15.6 0.1 9.6 6.2 0.0 3.3 3 0 0 3 3 3 0 Kelch motif BRCA2 PF00634.16 001079948.2_16126001_3 - 0.062 12.6 1.0 0.13 11.6 1.0 1.5 1 0 0 1 1 1 0 BRCA2 repeat polyprenyl_synt PF00348.15 001017656.1_16124001_3 - 1.1e-72 244.1 0.0 1.4e-72 243.7 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase KH_1 PF00013.27 001089428.1_16127001_2 - 1.7e-67 223.1 15.8 1e-17 63.5 0.3 4.2 4 0 0 4 4 4 4 KH domain KH_2 PF07650.15 001089428.1_16127001_2 - 3.9e-19 68.1 8.9 0.00012 21.7 1.2 4.5 4 0 0 4 4 4 4 KH domain DUF1897 PF09005.8 001089428.1_16127001_2 - 7.1e-08 31.7 29.9 5.6e-06 25.6 7.9 3.9 3 2 0 3 3 3 2 Domain of unknown function (DUF1897) KH_4 PF13083.4 001089428.1_16127001_2 - 1.6e-07 31.0 11.1 0.16 11.8 0.0 4.3 4 0 0 4 4 4 4 KH domain KH_5 PF13184.4 001089428.1_16127001_2 - 0.054 13.4 11.0 11 6.1 0.2 4.3 4 0 0 4 4 4 0 NusA-like KH domain Glyco_hydro_18 PF00704.26 213050.1_16124001_3 - 6.2e-74 249.4 0.0 7.4e-74 249.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_14 PF01607.22 213050.1_16124001_3 - 3.9e-11 42.8 6.2 6.6e-11 42.1 6.2 1.4 1 0 0 1 1 1 1 Chitin binding Peritrophin-A domain DCD PF06559.9 213050.1_16124001_3 - 0.14 10.8 0.0 0.2 10.3 0.0 1.1 1 0 0 1 1 1 0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) bZIP_1 PF00170.19 199723.1_16125001_1 - 7.5e-20 70.7 8.9 7.5e-20 70.7 8.9 2.3 3 0 0 3 3 3 1 bZIP transcription factor pKID PF02173.15 199723.1_16125001_1 - 2.5e-19 68.3 1.8 5.7e-19 67.2 1.8 1.6 1 0 0 1 1 1 1 pKID domain bZIP_2 PF07716.13 199723.1_16125001_1 - 6e-08 32.5 9.0 6e-08 32.5 9.0 2.0 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.15 199723.1_16125001_1 - 0.023 15.1 4.8 0.023 15.1 4.8 2.8 3 0 0 3 3 3 0 bZIP Maf transcription factor HrpB7 PF09486.8 199723.1_16125001_1 - 0.083 13.1 1.9 0.1 12.8 0.1 1.9 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) ASD2 PF08687.9 199723.1_16125001_1 - 0.75 9.2 8.1 0.031 13.8 1.7 1.8 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 ETF PF01012.19 198909.1_16124001_3 - 9.5e-42 142.8 0.9 1.3e-41 142.3 0.9 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.17 198909.1_16124001_3 - 1.9e-37 127.0 1.3 2.2e-37 126.8 0.2 1.7 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain 3-alpha PF03475.12 001109860.1_16122001_1 - 0.0046 16.7 0.6 0.012 15.3 0.4 1.8 2 0 0 2 2 2 1 3-alpha domain Crystall PF00030.17 001109860.1_16122001_2 - 2.7e-52 174.8 12.8 6.3e-27 93.5 3.2 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Crystall_3 PF08964.8 001109860.1_16122001_2 - 0.0078 16.2 3.4 0.96 9.5 0.1 3.2 2 1 1 3 3 3 2 Beta/Gamma crystallin Trypsin PF00089.24 001017724.2_16124001_1 - 1.7e-73 247.0 2.0 2.2e-73 246.6 2.0 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 001017724.2_16124001_1 - 3.9e-07 30.3 0.1 7.5e-07 29.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 001017724.2_16124001_1 - 1.1e-06 29.4 0.1 1.7e-06 28.9 0.1 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_M22 PF00814.23 001017751.2_16123001_2 - 1.6e-88 296.8 0.0 1.9e-88 296.6 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.13 001017751.2_16123001_2 - 0.0013 18.3 0.0 0.098 12.2 0.0 2.2 2 0 0 2 2 2 2 Carbamoyltransferase N-terminus BcrAD_BadFG PF01869.18 001017751.2_16123001_2 - 0.003 17.0 0.1 0.014 14.8 0.0 1.9 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family THAP PF05485.10 001037427.1_16126001_3 - 2.3e-10 41.2 1.3 1.2e-09 38.9 0.0 2.6 2 0 0 2 2 2 1 THAP domain ORC5_C PF14630.4 213198.1_16124001_3 - 3.4e-67 226.9 1.2 4.4e-67 226.5 1.2 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.4 213198.1_16124001_3 - 8.5e-14 52.1 0.0 1.7e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 213198.1_16124001_3 - 0.00016 21.8 0.0 0.00092 19.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain Lipocalin PF00061.21 001114899.1_16122001_2 - 1.1e-16 61.3 3.5 1.3e-16 61.0 3.5 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001114899.1_16122001_2 - 9.2e-05 22.2 1.2 0.00012 21.9 1.2 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.21 001114899.1_16122001_3 - 2.1e-13 50.5 3.6 3.1e-13 50.0 3.6 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001114899.1_16122001_3 - 0.00072 19.4 0.5 0.0011 18.8 0.5 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Arf PF00025.19 199824.1_16126001_1 - 5.8e-64 214.6 0.1 7.7e-64 214.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 199824.1_16126001_1 - 7.7e-15 55.0 0.1 1.2e-14 54.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 199824.1_16126001_1 - 1.5e-12 47.3 0.1 2.3e-12 46.7 0.1 1.2 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 199824.1_16126001_1 - 4.1e-11 42.5 0.1 5.7e-11 42.0 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 199824.1_16126001_1 - 1.2e-07 31.2 0.2 1.6e-05 24.1 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.21 199824.1_16126001_1 - 6.6e-06 26.1 0.1 9.6e-06 25.5 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 199824.1_16126001_1 - 8.2e-06 25.2 0.2 1.2e-05 24.7 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region BAR_3 PF16746.3 001039992.1_16124001_2 - 3.3e-14 53.0 6.9 5.7e-14 52.2 6.9 1.3 1 0 0 1 1 1 1 BAR domain of APPL family FlaC_arch PF05377.9 001039992.1_16124001_2 - 0.098 12.9 1.7 6.5 7.1 0.2 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) ApoLp-III PF07464.9 001039992.1_16124001_2 - 0.5 10.3 7.0 5.5 6.9 0.1 2.3 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) BST2 PF16716.3 001039992.1_16124001_2 - 6 7.4 10.7 3.5 8.1 2.9 2.8 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 Lectin_C PF00059.19 001040050.1_16123001_1 - 5e-20 72.1 1.6 5e-20 72.1 1.6 1.8 2 0 0 2 2 2 1 Lectin C-type domain DUF1616 PF07760.9 001040050.1_16123001_1 - 0.16 11.2 0.1 0.27 10.4 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1616) Amidohydro_1 PF01979.18 001123063.1_16126001_3 - 3.9e-33 115.1 2.7 3.9e-33 115.1 0.4 1.9 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_3 PF07969.9 001123063.1_16126001_3 - 1.5e-16 60.8 0.7 4.4e-08 32.9 0.0 3.1 2 1 1 3 3 3 2 Amidohydrolase family Amidohydro_2 PF04909.12 001123063.1_16126001_3 - 0.0064 16.2 0.0 0.0098 15.6 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase AP_endonuc_2 PF01261.22 001123063.1_16126001_3 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Usp PF00582.24 001123063.1_16126001_3 - 0.22 11.9 0.1 0.22 11.9 0.1 1.6 2 0 0 2 2 2 0 Universal stress protein family Peptidase_C2 PF00648.19 001040251.1_16125001_3 - 2.9e-110 367.8 0.0 4e-110 367.4 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 001040251.1_16125001_3 - 2.2e-41 141.3 0.1 3.8e-41 140.5 0.1 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_6 PF13405.4 001040251.1_16125001_3 - 8.3e-06 25.2 0.1 0.005 16.5 0.1 3.9 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.30 001040251.1_16125001_3 - 0.00045 19.4 0.0 0.068 12.6 0.0 3.4 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.4 001040251.1_16125001_3 - 0.0065 16.8 0.2 0.047 14.0 0.0 2.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.4 001040251.1_16125001_3 - 0.034 13.8 0.1 2.2 8.0 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain pair SPT_ssu-like PF11779.6 001159833.1_16126001_3 - 5.5e-17 61.0 8.0 1.3e-15 56.6 7.4 2.5 2 0 0 2 2 2 2 Small subunit of serine palmitoyltransferase-like Sec7 PF01369.18 001040307.1_16124001_1 - 9.1e-36 123.2 0.1 1.4e-35 122.6 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain F-box-like PF12937.5 001040307.1_16124001_1 - 1.5e-05 24.6 0.3 4e-05 23.3 0.3 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001040307.1_16124001_1 - 0.025 14.3 0.1 0.064 13.0 0.1 1.7 1 0 0 1 1 1 0 F-box domain Pkinase PF00069.23 001040358.1_16127001_3 - 1.8e-66 224.1 0.0 2.4e-66 223.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.20 001040358.1_16127001_3 - 6.5e-61 206.2 0.2 9.2e-61 205.7 0.2 1.2 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.15 001040358.1_16127001_3 - 4.9e-43 147.2 0.0 7.4e-43 146.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001040358.1_16127001_3 - 0.0012 18.1 0.0 0.0019 17.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like ELO PF01151.16 001040362.1_16123001_3 - 6.8e-60 202.5 28.3 8.8e-60 202.2 28.3 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family PLA2G12 PF06951.9 213430.1_16124001_2 - 3.3e-82 274.7 6.3 4.8e-82 274.1 6.3 1.2 1 0 0 1 1 1 1 Group XII secretory phospholipase A2 precursor (PLA2G12) Peptidase_M50 PF02163.20 001025461.1_16125001_2 - 4.3e-28 98.1 0.0 2.4e-27 95.7 0.0 1.9 1 1 0 1 1 1 1 Peptidase family M50 PDZ_2 PF13180.4 001025461.1_16125001_2 - 0.031 14.5 0.0 0.056 13.6 0.0 1.3 1 0 0 1 1 1 0 PDZ domain DUF2145 PF09916.7 001025461.1_16125001_2 - 0.033 13.7 0.0 0.077 12.5 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2145) PrmA PF06325.11 001130767.1_16126001_1 - 5.7e-08 32.4 0.0 9.6e-07 28.3 0.0 2.2 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.4 001130767.1_16126001_1 - 8e-05 23.1 0.0 0.00024 21.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.5 001130767.1_16126001_1 - 0.0018 18.1 0.1 0.0048 16.7 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.7 001130767.1_16126001_1 - 0.0023 17.5 0.1 0.0049 16.5 0.1 1.5 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.12 001130767.1_16126001_1 - 0.0029 17.0 0.2 0.013 14.9 0.1 2.0 2 0 0 2 2 2 1 Methyltransferase small domain TPR_14 PF13428.4 001130767.1_16126001_1 - 0.0073 16.9 0.0 0.23 12.2 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat CMAS PF02353.18 001130767.1_16126001_1 - 0.0079 15.4 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase TPR_2 PF07719.15 001130767.1_16126001_1 - 0.03 14.3 0.0 1.8 8.8 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.26 001130767.1_16126001_1 - 0.065 13.0 0.0 2 8.3 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat MAS20 PF02064.13 001130767.1_16126001_1 - 0.065 13.2 0.2 0.26 11.2 0.0 2.0 2 0 0 2 2 2 0 MAS20 protein import receptor Methyltransf_23 PF13489.4 001130767.1_16126001_1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MMR_HSR1 PF01926.21 001002140.1_16123001_3 - 6.5e-13 48.6 0.0 1.2e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001002140.1_16123001_3 - 2.7e-05 23.6 0.1 0.00013 21.3 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.14 001002140.1_16123001_3 - 0.00027 20.8 0.1 0.032 14.0 0.1 2.2 1 1 0 1 1 1 1 Protein of unknown function, DUF258 PPV_E1_C PF00519.15 001002140.1_16123001_3 - 0.007 15.1 0.0 0.0097 14.6 0.0 1.1 1 0 0 1 1 1 1 Papillomavirus helicase AAA_16 PF13191.4 001002140.1_16123001_3 - 0.015 15.6 0.1 0.034 14.4 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain Roc PF08477.11 001002140.1_16123001_3 - 0.019 15.1 0.0 0.042 14.0 0.0 1.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.21 001002140.1_16123001_3 - 0.023 14.6 0.3 0.88 9.5 0.1 2.4 1 1 1 2 2 2 0 Dynamin family AAA_22 PF13401.4 001002140.1_16123001_3 - 0.042 14.0 0.0 0.087 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AIG1 PF04548.14 001002140.1_16123001_3 - 0.047 12.9 0.0 0.073 12.2 0.0 1.3 1 0 0 1 1 1 0 AIG1 family Ras PF00071.20 001002140.1_16123001_3 - 0.069 12.6 0.0 0.73 9.3 0.0 2.2 2 0 0 2 2 2 0 Ras family ArgK PF03308.14 001002140.1_16123001_3 - 0.093 11.6 0.1 0.24 10.2 0.0 1.6 2 0 0 2 2 2 0 ArgK protein TniB PF05621.9 001002140.1_16123001_3 - 0.11 11.6 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein DUF815 PF05673.11 001002140.1_16123001_3 - 0.11 11.5 0.0 0.37 9.8 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF815) UQ_con PF00179.24 199952.1_16123001_3 - 1e-51 174.1 0.0 1.6e-51 173.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.20 199952.1_16123001_3 - 0.11 12.7 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 RWD domain Hydrolase_4 PF12146.6 001045343.1_16123001_1 - 1.3e-17 63.8 0.1 5.6e-11 42.0 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 001045343.1_16123001_1 - 3.6e-13 49.6 0.6 1.9e-10 40.7 0.2 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001045343.1_16123001_1 - 9.7e-07 29.5 0.0 9.2e-06 26.3 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.19 001045343.1_16123001_1 - 2.2e-05 23.9 0.0 8.7e-05 22.0 0.0 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family Thioesterase PF00975.18 001045343.1_16123001_1 - 0.00052 20.1 0.0 0.00092 19.3 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Peptidase_S15 PF02129.16 001045343.1_16123001_1 - 0.0024 17.4 0.2 0.024 14.1 0.1 2.1 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.14 001045343.1_16123001_1 - 0.0026 17.5 0.1 0.035 13.8 0.0 2.0 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase Gemini_mov PF01708.14 001045343.1_16123001_1 - 0.021 14.5 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 Geminivirus putative movement protein BAAT_C PF08840.9 001045343.1_16123001_1 - 0.023 14.5 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_5 PF12695.5 001045343.1_16123001_1 - 0.043 13.4 0.1 0.61 9.7 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase family DLH PF01738.16 001045343.1_16123001_1 - 0.058 12.8 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family RNase_PH PF01138.19 001045352.2_16122001_1 - 2.6e-23 82.8 0.1 1.2e-22 80.7 0.0 1.9 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.13 001045352.2_16122001_1 - 1.1e-09 38.1 0.0 1.8e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 AIG1 PF04548.14 001130619.1_16124001_2 - 1.1e-09 37.8 0.3 1.1e-09 37.8 0.3 2.5 2 1 0 3 3 3 1 AIG1 family Septin PF00735.16 001130619.1_16124001_2 - 2.4e-08 33.4 0.2 2.4e-08 33.4 0.2 1.8 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.21 001130619.1_16124001_2 - 9e-08 32.1 0.6 5.8e-07 29.5 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.4 001130619.1_16124001_2 - 0.00012 22.2 0.2 0.00077 19.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.14 001130619.1_16124001_2 - 0.00018 21.3 0.0 0.00057 19.7 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.4 001130619.1_16124001_2 - 0.0005 20.4 0.1 0.004 17.4 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain T2SSE PF00437.18 001130619.1_16124001_2 - 0.00082 18.4 0.7 0.0017 17.3 0.1 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_33 PF13671.4 001130619.1_16124001_2 - 0.00089 19.3 2.2 1.1 9.2 0.0 3.4 3 0 0 3 3 3 1 AAA domain GTP_EFTU PF00009.25 001130619.1_16124001_2 - 0.0012 18.3 0.1 0.0012 18.3 0.1 2.3 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA PF00004.27 001130619.1_16124001_2 - 0.0018 18.5 2.8 0.0066 16.7 0.0 2.8 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.4 001130619.1_16124001_2 - 0.003 17.1 0.0 0.0056 16.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.25 001130619.1_16124001_2 - 0.004 17.5 4.6 0.0049 17.2 0.0 2.7 3 0 0 3 3 3 1 ABC transporter KAP_NTPase PF07693.12 001130619.1_16124001_2 - 0.0081 15.3 4.7 0.091 11.8 4.7 2.4 1 1 0 1 1 1 1 KAP family P-loop domain RNA_helicase PF00910.20 001130619.1_16124001_2 - 0.0082 16.4 1.3 0.044 14.1 0.0 2.6 2 1 0 2 2 2 1 RNA helicase TsaE PF02367.15 001130619.1_16124001_2 - 0.0089 15.9 0.0 0.023 14.6 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.4 001130619.1_16124001_2 - 0.0099 16.0 0.1 0.0099 16.0 0.1 2.6 3 1 1 4 4 3 1 AAA domain AAA_11 PF13086.4 001130619.1_16124001_2 - 0.01 15.4 8.2 0.24 10.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.4 001130619.1_16124001_2 - 0.011 16.0 0.2 0.082 13.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.10 001130619.1_16124001_2 - 0.022 13.9 1.7 0.072 12.2 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin PduV-EutP PF10662.7 001130619.1_16124001_2 - 0.024 14.2 0.1 0.059 13.0 0.1 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.4 001130619.1_16124001_2 - 0.027 13.9 0.0 0.072 12.5 0.0 1.8 2 0 0 2 2 1 0 AAA domain SRP54 PF00448.20 001130619.1_16124001_2 - 0.035 13.6 0.2 0.035 13.6 0.2 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Roc PF08477.11 001130619.1_16124001_2 - 0.041 14.0 2.2 0.088 12.9 0.0 2.6 3 1 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase Sigma54_activat PF00158.24 001130619.1_16124001_2 - 0.048 13.2 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_30 PF13604.4 001130619.1_16124001_2 - 0.054 13.1 0.1 0.13 11.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.13 001130619.1_16124001_2 - 0.058 13.2 4.5 0.089 12.7 0.0 2.8 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_5 PF07728.12 001130619.1_16124001_2 - 0.059 13.2 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.4 001130619.1_16124001_2 - 0.099 13.0 7.4 0.22 11.9 0.1 3.7 3 1 1 4 4 4 0 AAA domain NACHT PF05729.10 001130619.1_16124001_2 - 0.1 12.4 2.8 0.25 11.1 0.3 2.6 3 0 0 3 3 3 0 NACHT domain AAA_14 PF13173.4 001130619.1_16124001_2 - 0.13 12.2 0.0 0.13 12.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.15 001130619.1_16124001_2 - 0.47 10.3 7.4 1.4 8.8 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function DUF87 SMC_N PF02463.17 001130619.1_16124001_2 - 0.54 9.5 0.0 0.54 9.5 0.0 2.4 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.4 001130619.1_16124001_2 - 4.1 7.7 23.3 28 5.0 23.2 2.5 1 1 0 1 1 1 0 AAA domain YhhN PF07947.12 001045368.1_16126001_2 - 2.7e-36 124.8 19.0 5.5e-36 123.8 19.0 1.5 1 0 0 1 1 1 1 YhhN family UDPGT PF00201.16 001045386.1_16124001_1 - 4.9e-159 530.2 0.2 5.7e-159 530.0 0.2 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001045386.1_16124001_1 - 8.2e-10 38.8 0.0 1.5e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain SR-25 PF10500.7 214776.1_16123001_1 - 0.55 9.7 20.4 0.76 9.2 20.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SPRY PF00622.26 214776.1_16123001_3 - 1.5e-17 63.7 0.0 2.9e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 SPRY domain BRICHOS PF04089.12 199980.1_16124001_3 - 1.2e-19 70.1 0.0 2.2e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 BRICHOS domain Myelin_PLP PF01275.17 214687.1_16127001_3 - 9.9e-90 300.4 18.0 1.7e-89 299.6 18.0 1.4 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) DUF1731 PF08338.9 001076578.1_16124001_1 - 7.6e-18 63.9 0.0 1.4e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1731) Epimerase PF01370.19 001076578.1_16124001_1 - 1.9e-07 30.6 0.0 0.00047 19.5 0.0 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.4 001076578.1_16124001_1 - 0.0049 16.7 0.0 0.0079 16.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.8 001076578.1_16124001_1 - 0.01 15.6 0.0 0.79 9.5 0.2 2.1 1 1 1 2 2 2 0 KR domain RmlD_sub_bind PF04321.15 001076578.1_16124001_1 - 0.046 12.7 0.0 0.069 12.1 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Pyr_redox PF00070.25 001076578.1_16124001_1 - 0.12 12.9 0.0 0.2 12.1 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GDP_Man_Dehyd PF16363.3 001076578.1_16124001_1 - 0.17 11.1 0.1 0.32 10.2 0.1 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Lipocalin_2 PF08212.10 001076582.2_16122001_2 - 3.5e-18 65.8 0.0 4.8e-18 65.4 0.0 1.2 1 0 0 1 1 1 1 Lipocalin-like domain Lipocalin PF00061.21 001076582.2_16122001_2 - 7.7e-17 61.7 0.0 1e-16 61.3 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Triabin PF03973.11 001076582.2_16122001_2 - 0.093 12.5 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Triabin CBFD_NFYB_HMF PF00808.21 001351798.1_16122001_2 - 2.7e-16 59.5 0.3 2.7e-16 59.5 0.3 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.22 001351798.1_16122001_2 - 3.8e-09 36.9 0.0 4.9e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.4 001351798.1_16122001_2 - 0.00031 20.7 0.1 0.00044 20.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.15 001351798.1_16122001_2 - 0.024 14.7 0.2 0.041 13.9 0.2 1.4 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) DUF2464 PF10240.7 001076606.1_16125001_1 - 1.8e-83 279.7 0.0 2.4e-83 279.3 0.0 1.2 1 0 0 1 1 1 1 Multivesicular body subunit 12 Proteasome PF00227.24 001281802.1_16124001_1 - 6.3e-30 103.9 0.0 1.6e-16 60.2 0.0 2.2 2 0 0 2 2 2 2 Proteasome subunit Mito_carr PF00153.25 001076632.1_16124001_2 - 1.1e-61 204.6 0.2 1.1e-25 89.3 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein 7tm_1 PF00001.19 001316949.1_16123001_1 - 1.8e-33 115.8 21.6 2.3e-33 115.5 21.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001316949.1_16123001_1 - 0.25 10.9 9.4 0.47 10.0 1.2 2.3 2 0 0 2 2 2 0 Olfactory receptor UDPGT PF00201.16 001177334.1_16124001_1 - 6.4e-183 609.0 0.1 7.7e-183 608.7 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001177334.1_16124001_1 - 2e-07 31.0 0.0 3.6e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.16 001177342.1_16124001_3 - 1.2e-182 608.1 0.1 1.4e-182 607.9 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001177342.1_16124001_3 - 3e-07 30.4 0.0 4.9e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 001177342.1_16124001_3 - 0.08 12.8 0.0 0.59 10.0 0.0 2.1 1 1 0 1 1 1 0 Glycosyltransferase Family 4 TMEM100 PF16311.3 001177342.1_16124001_3 - 0.22 11.0 1.5 0.49 9.9 1.5 1.5 1 0 0 1 1 1 0 Transmembrane protein 100 TMEM52 PF14979.4 001177342.1_16124001_3 - 0.64 9.8 5.2 1.4 8.7 5.2 1.5 1 0 0 1 1 1 0 Transmembrane 52 CTD_bind PF04818.11 200074.3_16127001_2 - 5.1e-18 65.5 0.7 1.7e-17 63.9 0.7 2.0 1 0 0 1 1 1 1 RNA polymerase II-binding domain. Surp PF01805.18 200074.3_16127001_2 - 4.1e-16 58.6 0.6 1.4e-15 56.9 0.6 2.0 1 0 0 1 1 1 1 Surp module G-patch PF01585.21 200074.3_16127001_2 - 2.4e-11 43.3 5.8 4.8e-11 42.3 5.8 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 200074.3_16127001_2 - 0.074 13.0 1.4 0.26 11.3 1.4 1.9 1 0 0 1 1 1 0 G-patch domain DUF936 PF06075.10 200074.3_16127001_2 - 0.57 8.9 19.7 1 8.1 19.7 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Presenilin PF01080.15 200074.3_16127001_2 - 1.2 7.6 11.1 2 6.9 11.1 1.2 1 0 0 1 1 1 0 Presenilin MIP-T3 PF10243.7 200074.3_16127001_2 - 2 6.9 19.0 4.3 5.8 19.0 1.4 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Frag1 PF10277.7 001002135.1_16124001_2 - 1.3e-50 171.9 17.9 1.3e-50 171.9 17.9 1.6 2 0 0 2 2 2 1 Frag1/DRAM/Sfk1 family NfeD PF01957.16 001002135.1_16124001_2 - 8.1 6.7 9.2 1.5 9.1 2.2 2.5 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding Crystall PF00030.17 001002138.1_16122001_1 - 1.7e-50 169.0 14.5 2.8e-25 88.2 4.8 2.2 2 0 0 2 2 2 2 Beta/Gamma crystallin Crystall_3 PF08964.8 001002138.1_16122001_1 - 0.00014 21.9 4.8 0.23 11.5 0.1 3.6 2 1 1 3 3 3 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 001002138.1_16122001_1 - 0.00017 21.3 11.4 0.023 14.5 3.0 3.1 2 1 1 3 3 3 2 Peptidase inhibitor family I36 Pkinase PF00069.23 001076751.1_16124001_2 - 2.6e-50 171.1 0.1 3.4e-50 170.7 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001076751.1_16124001_2 - 1.1e-22 80.4 0.1 1.9e-22 79.7 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase zf-RING_2 PF13639.4 001077256.1_16123001_2 - 8.7e-13 48.2 30.1 4.2e-07 30.0 9.8 3.0 3 0 0 3 3 2 2 Ring finger domain zf-RING_UBOX PF13445.4 001077256.1_16123001_2 - 2e-11 43.6 19.2 7.8e-07 28.9 3.4 3.2 2 2 2 4 4 4 2 RING-type zinc-finger zf-RING_5 PF14634.4 001077256.1_16123001_2 - 6.9e-11 41.8 26.2 2.5e-05 24.0 10.1 2.7 2 0 0 2 2 2 2 zinc-RING finger domain zf-RING_11 PF17123.3 001077256.1_16123001_2 - 2.9e-10 39.5 17.3 8.3e-06 25.3 1.5 3.6 2 2 0 2 2 2 2 RING-like zinc finger zf-C3HC4 PF00097.23 001077256.1_16123001_2 - 8.5e-09 35.0 27.5 3.2e-05 23.6 9.9 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001077256.1_16123001_2 - 1.4e-08 34.7 26.5 0.00037 20.6 7.2 3.8 3 1 0 3 3 3 2 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.4 001077256.1_16123001_2 - 6.2e-08 32.3 23.1 0.00071 19.3 8.1 3.1 2 1 1 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 001077256.1_16123001_2 - 2.6e-07 30.5 17.7 0.0031 17.4 5.8 3.3 2 2 0 2 2 2 2 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.4 001077256.1_16123001_2 - 8e-07 28.7 26.4 0.0027 17.4 4.7 3.7 2 1 1 3 3 3 2 Prokaryotic RING finger family 4 IQ PF00612.25 001077256.1_16123001_2 - 8.1e-06 25.1 0.4 2.9e-05 23.4 0.4 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif zf-C3HC4_2 PF13923.4 001077256.1_16123001_2 - 0.002 17.8 30.2 0.0066 16.1 10.5 3.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.4 001077256.1_16123001_2 - 0.0089 16.0 16.5 0.28 11.2 3.8 3.7 2 1 1 3 3 3 2 Zinc-binding RING-finger Pellino PF04710.12 001077256.1_16123001_2 - 0.036 12.6 7.8 0.29 9.6 0.9 2.2 2 0 0 2 2 2 0 Pellino zf-RING_4 PF14570.4 001077256.1_16123001_2 - 0.088 12.4 20.3 0.37 10.4 4.0 3.4 3 2 0 3 3 3 0 RING/Ubox like zinc-binding domain CD20 PF04103.13 001328009.1_16123001_2 - 1.1e-22 80.7 18.2 1.1e-21 77.4 18.2 2.1 1 1 0 1 1 1 1 CD20-like family Spp-24 PF07448.9 001327983.1_16123001_1 - 1.2e-12 47.6 0.0 2.4e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Cathelicidins PF00666.15 001327983.1_16123001_1 - 0.0014 18.8 0.0 0.0023 18.1 0.0 1.3 1 0 0 1 1 1 1 Cathelicidin RasGAP PF00616.17 001308967.1_16129001_1 - 7e-54 182.5 0.1 2.2e-53 180.9 0.0 1.9 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.13 001308967.1_16129001_1 - 8.8e-32 109.9 10.4 8.8e-32 109.9 10.4 3.1 3 0 0 3 3 3 1 RasGAP C-terminus CH PF00307.29 001308967.1_16129001_1 - 1.8e-16 60.1 0.1 7.7e-16 58.1 0.0 2.2 2 0 0 2 2 2 1 Calponin homology (CH) domain IQ PF00612.25 001308967.1_16129001_1 - 4.6e-07 28.9 38.3 0.00095 18.6 0.1 6.1 6 0 0 6 6 6 4 IQ calmodulin-binding motif CAMSAP_CH PF11971.6 001308967.1_16129001_1 - 0.053 13.2 0.0 0.2 11.4 0.0 1.9 1 0 0 1 1 1 0 CAMSAP CH domain DUF735 PF05246.9 001308967.1_16129001_1 - 0.084 12.7 0.5 1.3 8.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF735) CAMSAP_CC1 PF17095.3 001308967.1_16129001_1 - 1.6 8.5 6.6 0.37 10.5 2.1 2.3 2 0 0 2 2 2 0 Spectrin-binding region of Ca2+-Calmodulin 7tm_1 PF00001.19 001258224.1_16124001_1 - 5e-54 183.2 14.4 6.6e-54 182.8 14.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001258224.1_16124001_1 - 3.4e-12 46.2 12.9 4.7e-12 45.7 12.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001258224.1_16124001_1 - 1.5e-06 27.6 17.2 2.9e-06 26.7 17.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.7 001258224.1_16124001_1 - 8.7e-06 25.1 10.0 1.3e-05 24.6 10.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001258224.1_16124001_1 - 0.0032 17.1 4.3 0.0032 17.1 4.3 2.2 2 1 0 2 2 2 1 Olfactory receptor Git3 PF11710.6 001258224.1_16124001_1 - 0.011 15.4 14.2 0.019 14.6 14.2 1.4 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 PIH1 PF08190.10 001002309.1_16122001_1 - 1.1e-09 38.5 0.0 1.3e-09 38.2 0.0 1.1 1 0 0 1 1 1 1 pre-RNA processing PIH1/Nop17 Pkinase_Tyr PF07714.15 001020750.1_16125001_1 - 5.2e-61 206.1 0.0 8.4e-61 205.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001020750.1_16125001_1 - 1.5e-55 188.3 0.0 3.4e-55 187.1 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.21 001020750.1_16125001_1 - 0.0074 16.1 0.0 0.015 15.1 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family IncA PF04156.12 001020750.1_16125001_1 - 1.5 8.4 9.4 2.6 7.6 9.4 1.3 1 0 0 1 1 1 0 IncA protein Trm112p PF03966.14 001020752.1_16122001_1 - 2e-14 53.8 0.0 3.2e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 Trm112p-like protein OAD_gamma PF04277.11 001020752.1_16122001_1 - 2.6 8.6 4.1 4 7.9 4.1 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain FAM167 PF11652.6 001077335.1_16124001_3 - 4.7e-37 126.2 1.0 9.7e-37 125.2 1.0 1.6 1 0 0 1 1 1 1 FAM167 DUF2388 PF09498.8 001077335.1_16124001_3 - 0.028 14.2 0.2 0.052 13.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2388) Pkinase PF00069.23 001077344.1_16125001_3 - 1.5e-67 227.6 0.0 2.1e-67 227.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain PH_3 PF14593.4 001077344.1_16125001_3 - 7.5e-42 141.5 0.0 1.7e-41 140.4 0.0 1.5 1 0 0 1 1 1 1 PH domain Pkinase_Tyr PF07714.15 001077344.1_16125001_3 - 2e-34 118.9 0.0 2.8e-34 118.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001077344.1_16125001_3 - 6.1e-06 25.6 0.0 2.1e-05 23.8 0.0 1.7 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.4 001077344.1_16125001_3 - 0.0046 16.5 0.1 1.8 8.0 0.0 2.5 1 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 001077344.1_16125001_3 - 0.019 14.2 0.0 0.031 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001077344.1_16125001_3 - 0.032 14.0 0.0 0.41 10.4 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family PET PF06297.12 183342.2_16126001_2 - 2.8e-37 126.8 1.0 7.3e-37 125.4 0.6 2.0 2 0 0 2 2 2 1 PET Domain LIM PF00412.20 183342.2_16126001_2 - 2.1e-24 85.4 40.2 1e-09 38.3 8.7 4.3 3 1 0 3 3 3 3 LIM domain Vasculin PF15337.4 183342.2_16126001_2 - 0.025 15.2 0.2 0.13 12.9 0.0 2.4 2 0 0 2 2 2 0 Vascular protein family Vasculin-like 1 Ecl1 PF12855.5 183342.2_16126001_2 - 1.2 8.6 10.0 0.29 10.5 3.2 3.3 2 1 0 2 2 2 0 Life-span regulatory factor Crystall PF00030.17 001020783.1_16122001_2 - 1.4e-54 182.1 10.2 8.4e-28 96.3 1.2 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin Crystall_3 PF08964.8 001020783.1_16122001_2 - 0.0001 22.3 1.2 0.34 11.0 0.1 2.8 1 1 2 3 3 3 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 001020783.1_16122001_2 - 0.00045 20.0 6.1 0.11 12.3 0.9 3.3 1 1 2 3 3 3 3 Peptidase inhibitor family I36 HMG_box PF00505.17 001284432.1_16124001_1 - 2.4e-25 88.6 1.4 4.9e-25 87.6 1.4 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box Sox_N PF12444.6 001284432.1_16124001_1 - 5e-18 65.9 0.7 5e-18 65.9 0.7 3.0 3 0 0 3 3 3 1 Sox developmental protein N terminal HMG_box_2 PF09011.8 001284432.1_16124001_1 - 3.3e-10 40.3 0.6 6.9e-10 39.2 0.6 1.5 1 0 0 1 1 1 1 HMG-box domain DIL PF01843.17 001289880.1_16126001_1 - 7.1e-25 87.2 0.1 1.7e-24 86.0 0.1 1.7 1 0 0 1 1 1 1 DIL domain RA PF00788.21 001289880.1_16126001_1 - 2.4e-05 24.7 0.3 0.00086 19.8 0.1 3.0 2 1 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Cadherin PF00028.15 001024125.1_16129001_3 - 1e-78 259.7 2.5 2.3e-17 63.0 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001024125.1_16129001_3 - 2.9e-34 116.6 0.5 1.3e-30 104.9 0.0 4.7 6 0 0 6 6 6 1 Cadherin-like Cadherin_tail PF15974.3 001024125.1_16129001_3 - 5.3e-18 65.5 9.4 5.3e-18 65.5 9.4 2.6 2 1 0 2 2 2 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001024125.1_16129001_3 - 5.2e-11 43.0 0.4 3.7e-10 40.3 0.1 2.6 3 0 0 3 3 3 1 Cadherin cytoplasmic C-terminal He_PIG PF05345.10 001024125.1_16129001_3 - 0.052 13.6 2.9 0.91 9.6 0.0 3.4 3 0 0 3 3 3 0 Putative Ig domain DUF4394 PF14339.4 001024125.1_16129001_3 - 0.16 11.2 0.9 3.2 6.9 0.0 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4394) APS_kinase PF01583.18 001077767.1_16126001_2 - 2.9e-72 241.6 0.0 4.4e-72 241.0 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase ATP-sulfurylase PF01747.15 001077767.1_16126001_2 - 7.9e-70 234.5 0.0 1.1e-69 234.0 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.4 001077767.1_16126001_2 - 1.6e-49 167.5 0.0 3.1e-49 166.6 0.0 1.5 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.4 001077767.1_16126001_2 - 2.8e-05 24.2 0.0 6.5e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 001077767.1_16126001_2 - 0.0007 20.0 0.0 0.0018 18.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain FKBP_C PF00254.26 001012249.2_16122001_1 - 1.9e-24 85.7 0.0 2.6e-24 85.2 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Cadherin PF00028.15 001024179.1_16128001_2 - 8.6e-84 276.0 8.4 1.9e-17 63.3 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001024179.1_16128001_2 - 6.9e-36 123.4 7.3 1.2e-35 122.6 7.3 1.3 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001024179.1_16128001_2 - 1e-28 98.8 2.1 5.2e-26 90.1 0.2 4.0 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.3 001024179.1_16128001_2 - 9e-23 80.7 0.1 2.9e-22 79.1 0.1 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001024179.1_16128001_2 - 3.3e-05 23.7 13.4 0.37 10.7 0.1 5.3 4 1 1 5 5 5 4 Cadherin-like TMEM154 PF15102.4 001024179.1_16128001_2 - 0.031 14.1 0.1 0.074 12.8 0.1 1.6 1 0 0 1 1 1 0 TMEM154 protein family PRAP PF15314.4 001327763.1_16123001_2 - 1.4e-15 57.4 30.5 7.5e-09 35.8 6.0 3.1 3 0 0 3 3 3 2 Proline-rich acidic protein 1, pregnancy-specific uterine Cadherin PF00028.15 001024185.1_16128001_2 - 1.4e-81 268.9 4.5 8.4e-18 64.5 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001024185.1_16128001_2 - 4.2e-36 124.1 7.1 8.1e-36 123.2 7.1 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001024185.1_16128001_2 - 3.9e-30 103.4 0.9 1.1e-26 92.3 0.2 3.9 4 0 0 4 4 4 2 Cadherin-like Cadherin_C_2 PF16492.3 001024185.1_16128001_2 - 2e-24 86.0 0.2 4e-22 78.7 0.0 2.9 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001024185.1_16128001_2 - 0.005 16.7 7.1 0.65 9.9 0.1 4.6 4 1 1 5 5 5 2 Cadherin-like TMEM154 PF15102.4 001024185.1_16128001_2 - 0.026 14.3 0.1 0.074 12.8 0.1 1.7 1 0 0 1 1 1 0 TMEM154 protein family DUF4604 PF15377.4 001032728.1_16122001_1 - 0.00027 21.3 10.5 0.00033 21.0 10.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) COX7a PF02238.13 001032728.1_16122001_2 - 5e-08 33.1 0.0 8e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII Connexin PF00029.17 001032728.1_16122001_3 - 0.0045 16.6 2.2 0.0071 16.0 2.2 1.3 1 0 0 1 1 1 1 Connexin 7tm_1 PF00001.19 001032728.1_16122001_3 - 0.015 14.5 2.0 0.017 14.2 2.0 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF4604 PF15377.4 001032728.1_16122001_3 - 1.4 9.2 23.1 2.1 8.6 23.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Eapp_C PF10238.7 001032728.1_16122001_3 - 2.5 8.0 13.6 0.079 12.9 7.3 1.6 2 0 0 2 2 2 0 E2F-associated phosphoprotein AP3D1 PF06375.9 001032728.1_16122001_3 - 5.1 7.2 29.1 7.2 6.7 29.1 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Peptidase_M10 PF00413.22 194416.1_16128001_3 - 8.1e-57 191.4 0.0 1.3e-56 190.7 0.0 1.4 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 194416.1_16128001_3 - 8.6e-47 156.7 19.1 4e-12 45.8 0.2 4.5 4 0 0 4 4 4 4 Hemopexin DUF3377 PF11857.6 194416.1_16128001_3 - 7.8e-24 83.3 0.1 2.8e-23 81.5 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3377) PG_binding_1 PF01471.16 194416.1_16128001_3 - 1.3e-08 34.8 0.0 3.1e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 194416.1_16128001_3 - 0.0035 16.8 1.1 0.97 8.9 0.1 2.2 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Metallopep PF12044.6 194416.1_16128001_3 - 0.094 11.2 0.0 0.15 10.5 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_3 PF13582.4 194416.1_16128001_3 - 0.62 10.5 1.8 1.1 9.7 1.8 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like PIG-H PF10181.7 001002565.2_16123001_2 - 6.7e-20 70.6 0.1 1.4e-19 69.5 0.1 1.6 2 0 0 2 2 2 1 GPI-GlcNAc transferase complex, PIG-H component DUF2530 PF10745.7 001002565.2_16123001_2 - 0.31 11.1 0.9 0.57 10.3 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2530) O_anti_polymase PF01901.14 001024441.1_16122001_1 - 0.37 9.9 3.0 0.52 9.4 3.0 1.1 1 0 0 1 1 1 0 Putative O-antigen polymerase Folate_carrier PF01770.16 001024441.1_16122001_1 - 1.8 7.1 6.1 2.2 6.8 6.1 1.1 1 0 0 1 1 1 0 Reduced folate carrier Proteasome PF00227.24 001024441.1_16122001_3 - 2.5e-62 209.6 0.0 3.8e-62 209.0 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 001024441.1_16122001_3 - 5.7e-10 38.5 0.1 1.2e-09 37.5 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature EOS1 PF12326.6 001024441.1_16122001_3 - 0.17 11.7 0.1 0.14 11.9 0.1 1.2 1 0 0 1 1 1 0 N-glycosylation protein Conotoxin PF02950.15 001024441.1_16122001_3 - 0.19 12.6 2.8 0.34 11.8 2.8 1.4 1 0 0 1 1 1 0 Conotoxin YMF19 PF02326.13 001024441.1_16122001_3 - 5.1 7.8 8.4 12 6.7 8.4 1.6 1 0 0 1 1 1 0 Plant ATP synthase F0 VKG_Carbox PF05090.12 001024441.1_16122001_3 - 8.7 4.9 6.8 13 4.3 6.8 1.2 1 0 0 1 1 1 0 Vitamin K-dependent gamma-carboxylase Connexin PF00029.17 001024441.1_16122001_3 - 9.1 5.8 12.0 13 5.3 12.0 1.2 1 0 0 1 1 1 0 Connexin Rgp1 PF08737.8 001002608.1_16124001_1 - 1e-43 150.0 0.0 7.3e-22 78.0 0.0 2.2 2 0 0 2 2 2 2 Rgp1 EOS1 PF12326.6 200944.1_16123001_1 - 0.13 12.1 1.1 0.13 12.0 1.1 1.2 1 0 0 1 1 1 0 N-glycosylation protein Zip PF02535.20 200944.1_16123001_1 - 1 8.3 2.7 1.4 7.9 2.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.15 200944.1_16123001_1 - 8.5 4.9 7.1 10 4.6 7.1 1.1 1 0 0 1 1 1 0 Presenilin eIF-6 PF01912.16 200944.1_16123001_2 - 4.9e-80 267.4 0.1 7e-80 266.9 0.1 1.2 1 0 0 1 1 1 1 eIF-6 family EOS1 PF12326.6 200944.1_16123001_2 - 0.09 12.6 0.1 0.094 12.5 0.1 1.2 1 0 0 1 1 1 0 N-glycosylation protein Connexin PF00029.17 200944.1_16123001_2 - 2 8.0 11.3 2.9 7.5 11.3 1.3 1 0 0 1 1 1 0 Connexin AMP-binding PF00501.26 001031837.1_16127001_1 - 9.3e-109 363.7 0.0 1.7e-108 362.8 0.0 1.4 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.4 001031837.1_16127001_1 - 0.00055 20.7 0.0 0.0014 19.5 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Methyltransf_11 PF08241.10 001044784.1_16123001_3 - 5.5e-26 90.9 0.0 1.1e-25 90.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 001044784.1_16123001_3 - 4.1e-22 78.6 0.0 6.8e-22 77.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001044784.1_16123001_3 - 3.5e-14 52.7 0.0 5.2e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001044784.1_16123001_3 - 8e-12 45.6 0.0 1.3e-11 44.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 001044784.1_16123001_3 - 2.7e-11 43.1 0.0 4.1e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.4 001044784.1_16123001_3 - 2e-10 40.7 0.0 2.5e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.13 001044784.1_16123001_3 - 0.0007 19.4 0.0 0.0032 17.2 0.0 2.1 2 1 0 2 2 2 1 Hypothetical methyltransferase tRNA_U5-meth_tr PF05958.9 001044784.1_16123001_3 - 0.0032 16.4 0.0 0.0045 15.9 0.0 1.1 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase MTS PF05175.12 001044784.1_16123001_3 - 0.0038 16.7 0.0 0.0061 16.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain TPMT PF05724.9 001044784.1_16123001_3 - 0.067 12.7 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) DREV PF05219.10 001044784.1_16123001_3 - 0.073 12.0 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase NodS PF05401.9 001044784.1_16123001_3 - 0.19 11.2 0.0 0.32 10.4 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) SDF PF00375.16 001002666.1_16126001_1 - 7.7e-133 443.1 31.1 9.9e-133 442.8 31.1 1.1 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family Phage_holin_2_2 PF10746.7 001002666.1_16126001_1 - 0.017 14.7 0.1 0.054 13.0 0.1 1.8 1 0 0 1 1 1 0 Phage holin T7 family, holin superfamily II TRAM_LAG1_CLN8 PF03798.14 001002701.1_16123001_3 - 1.4e-14 54.2 6.0 2.2e-14 53.5 6.0 1.4 1 0 0 1 1 1 1 TLC domain Consortin_C PF15281.4 001002701.1_16123001_3 - 0.12 12.3 1.1 0.46 10.4 1.1 2.0 1 1 1 2 2 2 0 Consortin C-terminus CTP_transf_like PF01467.24 001037374.1_16124001_2 - 1.1e-31 109.9 0.1 1.9e-31 109.1 0.1 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like Pkinase_Tyr PF07714.15 001089574.1_16124001_3 - 9.9e-50 169.1 0.0 1.4e-49 168.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001089574.1_16124001_3 - 1.3e-48 165.5 0.0 2.3e-48 164.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.12 001089574.1_16124001_3 - 0.0001 21.6 0.1 0.00033 19.9 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MMR_HSR1 PF01926.21 001002875.1_16124001_3 - 1.6e-17 63.5 0.1 2.1e-14 53.4 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.16 001002875.1_16124001_3 - 1.5e-11 44.0 0.2 1.2e-08 34.6 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B DUF258 PF03193.14 001002875.1_16124001_3 - 1.2e-05 25.2 1.5 0.071 12.9 0.3 2.5 1 1 1 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001002875.1_16124001_3 - 2.4e-05 23.9 0.9 0.0011 18.4 0.2 3.1 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain GN3L_Grn1 PF08701.9 001002875.1_16124001_3 - 5.8e-05 23.0 8.5 5.8e-05 23.0 8.5 2.7 2 0 0 2 2 2 1 GNL3L/Grn1 putative GTPase Dynamin_N PF00350.21 001002875.1_16124001_3 - 0.046 13.6 0.1 0.046 13.6 0.1 3.3 2 2 1 3 3 3 0 Dynamin family cobW PF02492.17 001002875.1_16124001_3 - 0.083 12.3 0.1 4.9 6.6 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.11 001002875.1_16124001_3 - 0.13 12.4 0.1 7.4 6.7 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.4 001002875.1_16124001_3 - 0.58 10.5 0.0 0.58 10.5 0.0 2.4 2 1 0 2 2 2 0 AAA domain IBB PF01749.18 001002875.1_16124001_3 - 2.8 8.2 19.3 0.8 10.0 15.6 1.9 2 0 0 2 2 2 0 Importin beta binding domain UMP1 PF05348.9 001003424.2_16122001_1 - 5.4e-36 123.3 0.0 7.3e-36 122.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 RhoGEF PF00621.18 001177933.1_16127001_1 - 1.8e-44 152.0 0.3 1.8e-44 152.0 0.3 1.6 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.27 001177933.1_16127001_1 - 8.1e-22 77.6 0.1 4.8e-10 39.8 0.0 2.7 2 0 0 2 2 2 2 PH domain FYVE PF01363.19 001177933.1_16127001_1 - 2.7e-15 56.1 10.2 2.7e-15 56.1 10.2 2.0 2 0 0 2 2 2 1 FYVE zinc finger FYVE_2 PF02318.14 001177933.1_16127001_1 - 0.00021 21.4 3.9 0.00076 19.5 3.9 1.9 1 0 0 1 1 1 1 FYVE-type zinc finger IQ_SEC7_PH PF16453.3 001177933.1_16127001_1 - 0.0014 18.5 2.1 0.0017 18.2 0.1 2.1 2 0 0 2 2 2 1 PH domain DUF2884 PF11101.6 001177933.1_16127001_1 - 0.0032 16.9 0.0 0.012 15.0 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2884) DUF1411 PF07199.9 001177933.1_16127001_1 - 0.041 13.4 0.5 4.1 6.9 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1411) PH_13 PF16652.3 001177933.1_16127001_1 - 0.07 12.9 6.4 0.62 9.8 0.8 3.2 3 1 0 3 3 3 0 Pleckstrin homology domain PH_6 PF15406.4 001177933.1_16127001_1 - 0.084 13.0 0.0 13 6.0 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain DUF2181 PF10223.7 001003531.2_16123001_2 - 9e-78 260.9 0.0 1.2e-77 260.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2181) Ribosomal_L19 PF01245.18 001003544.2_16123001_3 - 2.9e-15 56.0 0.0 4.6e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L19 TFIID_30kDa PF03540.11 001044811.2_16122001_1 - 3.3e-26 90.9 0.0 5.1e-26 90.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Bromo_TP PF07524.11 001044811.2_16122001_1 - 0.028 14.3 0.0 0.31 11.0 0.0 2.2 1 1 0 1 1 1 0 Bromodomain associated WWE PF02825.18 001082810.1_16124001_1 - 3.3e-47 158.8 11.3 1.7e-15 57.2 0.8 4.3 4 0 0 4 4 4 3 WWE domain ARPC4 PF05856.10 001003762.1_16123001_1 - 2.2e-83 277.8 7.9 2.9e-83 277.4 7.9 1.2 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Sm_like PF16243.3 001003762.1_16123001_1 - 0.002 18.1 0.1 0.0046 16.9 0.1 1.6 1 0 0 1 1 1 1 Sm_like domain BTB PF00651.29 001002198.1_16125001_1 - 2.4e-24 85.6 0.1 6.1e-23 81.0 0.0 2.3 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.13 001002198.1_16125001_1 - 2.7e-22 78.7 0.1 7.1e-22 77.3 0.1 1.8 1 0 0 1 1 1 1 BTB And C-terminal Kelch F5_F8_type_C PF00754.23 001002198.1_16125001_1 - 1.6e-18 66.9 0.0 6e-08 32.7 0.0 2.2 2 0 0 2 2 2 2 F5/8 type C domain Arylesterase PF01731.18 001004542.1_16128001_1 - 9.6e-28 96.1 0.5 2.1e-27 95.0 0.5 1.6 1 0 0 1 1 1 1 Arylesterase SGL PF08450.10 001004542.1_16128001_1 - 6.4e-09 35.6 0.0 1.1e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Str_synth PF03088.14 001004542.1_16128001_1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Strictosidine synthase DUF485 PF04341.10 001110381.1_16123001_2 - 0.003 17.3 8.6 0.45 10.4 0.0 3.8 4 0 0 4 4 4 2 Protein of unknown function, DUF485 7tm_1 PF00001.19 001110381.1_16123001_2 - 0.015 14.4 16.6 0.66 9.0 16.6 2.8 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) YojJ PF10372.7 001270554.1_16125001_3 - 0.01 15.8 0.9 4.1 7.4 0.1 2.6 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus SseC PF04888.10 001270554.1_16125001_3 - 0.04 13.3 5.8 0.059 12.7 5.8 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Mem_trans PF03547.16 001270554.1_16125001_3 - 0.077 11.2 1.9 0.12 10.6 1.9 1.1 1 0 0 1 1 1 0 Membrane transport protein Nup88 PF10168.7 001270554.1_16125001_3 - 0.38 8.4 8.8 0.56 7.8 8.8 1.1 1 0 0 1 1 1 0 Nuclear pore component Spc7 PF08317.9 001270554.1_16125001_3 - 0.49 9.1 7.9 0.27 9.9 5.7 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein GlutR_dimer PF00745.18 001270554.1_16125001_3 - 6.4 7.1 6.6 32 4.9 1.9 3.4 2 1 1 3 3 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain Proteasome_A_N PF10584.7 023334.2_16122120_2 - 0.011 15.2 0.1 0.097 12.2 0.0 2.3 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature NHL PF01436.19 023334.2_16122120_2 - 0.072 13.0 0.5 9.3 6.4 0.0 3.7 4 0 0 4 4 4 0 NHL repeat Neugrin PF06413.9 120356.1_16122120_2 - 0.37 10.6 8.9 0.49 10.2 8.9 1.1 1 0 0 1 1 1 0 Neugrin DX PF01666.15 120356.1_16122120_3 - 0.072 13.4 1.9 0.23 11.8 0.5 2.4 2 1 0 2 2 2 0 DX module DCX PF03607.15 015625.1_16123120_3 - 4.7e-34 116.2 0.0 2.6e-19 69.0 0.0 2.5 2 0 0 2 2 2 2 Doublecortin Paf1 PF03985.11 015625.1_16123120_3 - 0.12 11.2 17.2 0.15 10.9 17.2 1.1 1 0 0 1 1 1 0 Paf1 PPP4R2 PF09184.9 015625.1_16123120_3 - 0.12 11.8 17.6 0.16 11.4 17.6 1.2 1 0 0 1 1 1 0 PPP4R2 NOA36 PF06524.10 015625.1_16123120_3 - 2.8 7.1 15.5 4.1 6.6 15.5 1.3 1 0 0 1 1 1 0 NOA36 protein RNA_polI_A34 PF08208.9 015625.1_16123120_3 - 3.3 7.6 22.9 5 7.1 22.9 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DDHD PF02862.15 015625.1_16123120_3 - 4.5 7.2 9.5 6.4 6.7 9.5 1.2 1 0 0 1 1 1 0 DDHD domain CD20 PF04103.13 001126474.1_16123001_2 - 3.8e-11 43.2 20.5 5.3e-09 36.2 20.5 2.4 1 1 0 1 1 1 1 CD20-like family XendoU PF09412.8 001044967.1_16124001_1 - 7.4e-105 349.8 0.1 9e-105 349.5 0.1 1.1 1 0 0 1 1 1 1 Endoribonuclease XendoU EndoU_bacteria PF14436.4 001044967.1_16124001_1 - 0.027 14.7 0.1 0.049 13.8 0.1 1.4 1 0 0 1 1 1 0 Bacterial EndoU nuclease PX PF00787.22 001082808.1_16129001_1 - 1.6e-18 66.6 0.0 3.9e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 PX domain Pkinase PF00069.23 001082808.1_16129001_1 - 7.9e-12 44.9 0.0 3.3e-11 42.9 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001082808.1_16129001_1 - 4.8e-11 42.3 0.0 1.5e-09 37.4 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase WH2 PF02205.18 001082808.1_16129001_1 - 9.3e-10 37.9 0.3 9.3e-10 37.9 0.3 2.1 2 0 0 2 2 2 1 WH2 motif V-set PF07686.15 001309818.1_16123001_3 - 7.1e-29 100.0 2.5 1.4e-13 50.8 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 001309818.1_16123001_3 - 3e-14 53.2 3.9 4.2e-06 27.1 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001309818.1_16123001_3 - 1.8e-11 43.8 0.8 0.00015 21.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 001309818.1_16123001_3 - 1.1e-09 38.2 5.4 4.9e-05 23.3 1.5 2.8 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001309818.1_16123001_3 - 7.3e-06 26.1 8.9 0.023 14.9 3.5 3.0 2 2 0 2 2 2 2 Immunoglobulin domain PRY PF13765.4 001044961.1_16124001_3 - 1.6e-22 78.7 0.1 4.3e-22 77.4 0.1 1.8 1 0 0 1 1 1 1 SPRY-associated domain zf-RING_UBOX PF13445.4 001044961.1_16124001_3 - 1.8e-09 37.3 9.4 1.8e-09 37.3 9.4 2.7 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001044961.1_16124001_3 - 3.7e-09 36.1 14.4 3.7e-09 36.1 14.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001044961.1_16124001_3 - 4.4e-09 36.2 3.2 4.4e-09 36.2 3.2 3.3 4 0 0 4 4 2 1 B-box zinc finger zf-C3HC4 PF00097.23 001044961.1_16124001_3 - 4.7e-09 35.8 14.8 1.5e-08 34.2 14.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001044961.1_16124001_3 - 6.6e-09 35.4 11.1 6.6e-09 35.4 11.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001044961.1_16124001_3 - 7.5e-08 32.3 14.6 7.5e-08 32.3 14.6 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 001044961.1_16124001_3 - 1.9e-07 30.8 13.9 1.9e-07 30.8 13.9 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 001044961.1_16124001_3 - 3.2e-07 30.4 14.3 3.2e-07 30.4 14.3 2.4 2 0 0 2 2 1 1 Ring finger domain zf-Nse PF11789.6 001044961.1_16124001_3 - 9e-06 25.3 7.5 9e-06 25.3 7.5 2.8 3 0 0 3 3 2 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.4 001044961.1_16124001_3 - 0.00016 21.3 13.0 0.00016 21.3 13.0 2.7 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 SPRY PF00622.26 001044961.1_16124001_3 - 0.00028 20.9 3.2 0.00077 19.4 3.2 1.8 1 1 0 1 1 1 1 SPRY domain U-box PF04564.13 001044961.1_16124001_3 - 0.00078 19.4 0.3 0.0029 17.6 0.0 2.1 2 0 0 2 2 1 1 U-box domain zf-RING_6 PF14835.4 001044961.1_16124001_3 - 0.0012 18.6 3.6 0.0045 16.7 3.6 2.0 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Apolipoprotein PF01442.16 001044961.1_16124001_3 - 0.0035 17.2 11.4 0.0057 16.5 11.4 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain zf-ANAPC11 PF12861.5 001044961.1_16124001_3 - 0.0052 16.7 3.2 0.022 14.7 3.2 2.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF812 PF05667.9 001044961.1_16124001_3 - 0.0063 15.3 11.1 0.008 15.0 11.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Histidinol_dh PF00815.18 001044961.1_16124001_3 - 0.015 14.2 1.4 0.021 13.7 1.4 1.2 1 0 0 1 1 1 0 Histidinol dehydrogenase zf-RING_10 PF16685.3 001044961.1_16124001_3 - 0.02 14.9 12.2 0.02 14.9 12.2 2.7 1 1 1 2 2 2 0 zinc RING finger of MSL2 Fib_alpha PF08702.8 001044961.1_16124001_3 - 0.025 14.6 13.1 0.064 13.3 13.1 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family ATP-synt_B PF00430.16 001044961.1_16124001_3 - 0.068 13.1 8.5 0.12 12.3 8.5 1.3 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Imm49 PF15575.4 001044961.1_16124001_3 - 0.097 12.3 0.7 0.15 11.6 0.7 1.2 1 0 0 1 1 1 0 Immunity protein 49 APG6 PF04111.10 001044961.1_16124001_3 - 0.14 11.3 13.6 0.25 10.6 13.6 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4200 PF13863.4 001044961.1_16124001_3 - 0.18 12.0 23.5 0.29 11.4 22.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) NPV_P10 PF05531.10 001044961.1_16124001_3 - 0.2 12.0 2.3 3.6 8.0 0.2 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.10 001044961.1_16124001_3 - 0.23 11.3 13.0 0.04 13.8 4.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF342 PF03961.11 001044961.1_16124001_3 - 0.41 9.1 10.5 0.59 8.5 10.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Baculo_PEP_C PF04513.10 001044961.1_16124001_3 - 0.45 10.4 1.7 2.4 8.1 1.9 1.9 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus CorA PF01544.16 001044961.1_16124001_3 - 0.61 9.2 4.9 0.94 8.6 4.9 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein ECH_2 PF16113.3 001044961.1_16124001_3 - 0.69 9.2 8.9 1.1 8.6 8.9 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase DUF3584 PF12128.6 001044961.1_16124001_3 - 0.72 7.2 15.2 1.1 6.5 15.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Phage_GP20 PF06810.9 001044961.1_16124001_3 - 0.74 9.5 16.0 0.72 9.5 5.2 2.2 1 1 1 2 2 2 0 Phage minor structural protein GP20 Exonuc_VII_L PF02601.13 001044961.1_16124001_3 - 0.8 9.1 9.2 1.2 8.5 9.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF489 PF04356.10 001044961.1_16124001_3 - 1.2 9.0 5.0 0.55 10.1 2.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF489) ALMT PF11744.6 001044961.1_16124001_3 - 2.1 7.0 10.0 3 6.4 10.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Syntaxin-6_N PF09177.9 001044961.1_16124001_3 - 2.2 8.7 10.6 3.8 8.0 2.7 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal ApoO PF09769.7 001044961.1_16124001_3 - 2.3 8.1 6.1 18 5.2 1.1 2.4 1 1 1 2 2 2 0 Apolipoprotein O End3 PF12761.5 001044961.1_16124001_3 - 2.5 8.1 15.6 4.1 7.4 15.6 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Bacillus_HBL PF05791.9 001044961.1_16124001_3 - 3.7 7.1 11.0 3.7 7.1 8.3 2.2 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Zn_ribbon_17 PF17120.3 001044961.1_16124001_3 - 3.7 7.1 11.4 4.1 7.0 9.0 2.4 2 0 0 2 2 1 0 Zinc-ribbon, C4HC2 type CLZ PF16526.3 001044961.1_16124001_3 - 4 7.7 12.4 16 5.8 5.4 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TMPIT PF07851.11 001044961.1_16124001_3 - 4.3 6.4 16.6 12 4.9 16.6 1.7 1 1 0 1 1 1 0 TMPIT-like protein Topoisom_I_N PF02919.13 001044961.1_16124001_3 - 5 6.4 11.1 10 5.5 11.1 1.5 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment DUF2203 PF09969.7 001044961.1_16124001_3 - 5.4 7.6 10.5 70 4.0 10.5 2.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) zf-rbx1 PF12678.5 001044961.1_16124001_3 - 7.8 6.7 20.8 0.36 11.0 12.7 2.8 2 1 0 2 2 2 0 RING-H2 zinc finger domain CENP-Q PF13094.4 001044961.1_16124001_3 - 8.2 6.5 17.3 15 5.6 17.3 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit zf-RING-like PF08746.9 001044961.1_16124001_3 - 9.2 6.5 16.2 3.8 7.8 11.8 2.7 2 1 0 2 2 2 0 RING-like domain Myc_target_1 PF15179.4 001082917.1_16122001_3 - 8.4e-88 293.2 3.8 1.3e-87 292.6 3.8 1.3 1 0 0 1 1 1 1 Myc target protein 1 DUF2613 PF11021.6 001082917.1_16122001_3 - 0.1 12.6 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) DUF1049 PF06305.9 001082917.1_16122001_3 - 0.52 10.0 2.7 1.1 9.0 2.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Pkinase PF00069.23 001328029.1_16124001_1 - 9.6e-40 136.5 0.0 2e-39 135.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001328029.1_16124001_1 - 2.6e-18 66.1 0.0 6.3e-18 64.9 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001328029.1_16124001_1 - 0.019 14.7 0.0 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Collagen PF01391.16 001127513.1_16124001_1 - 6.5e-61 201.8 231.7 1.7e-08 33.9 34.0 9.3 2 2 5 7 7 7 6 Collagen triple helix repeat (20 copies) PRY PF13765.4 001045270.2_16125001_2 - 2.2e-19 68.7 0.3 7.5e-19 67.0 0.3 2.0 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_4 PF15227.4 001045270.2_16125001_2 - 6.6e-12 45.2 11.9 6.6e-12 45.2 11.9 4.7 5 0 0 5 5 3 1 zinc finger of C3HC4-type, RING SPRY PF00622.26 001045270.2_16125001_2 - 2.3e-10 40.5 0.1 4.8e-10 39.5 0.1 1.5 1 0 0 1 1 1 1 SPRY domain zf-RING_UBOX PF13445.4 001045270.2_16125001_2 - 1.7e-09 37.4 5.7 1.7e-09 37.4 5.7 3.7 4 1 1 5 5 4 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001045270.2_16125001_2 - 1.9e-08 33.9 9.2 1.9e-08 33.9 9.2 4.0 4 1 1 5 5 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001045270.2_16125001_2 - 1e-07 31.6 10.4 1e-07 31.6 10.4 4.6 5 0 0 5 5 3 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001045270.2_16125001_2 - 1.4e-07 31.4 9.5 1.4e-07 31.4 9.5 5.4 5 1 1 6 6 5 1 B-box zinc finger zf-C3HC4_3 PF13920.4 001045270.2_16125001_2 - 1.6e-06 27.7 6.9 1.6e-06 27.7 6.9 4.6 5 0 0 5 5 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001045270.2_16125001_2 - 1.5e-05 25.0 10.0 1.5e-05 25.0 10.0 4.8 4 0 0 4 4 4 1 Ring finger domain zf-RING_5 PF14634.4 001045270.2_16125001_2 - 0.00016 21.5 8.2 0.00016 21.5 8.2 4.7 5 1 0 5 5 4 1 zinc-RING finger domain U-box PF04564.13 001045270.2_16125001_2 - 0.0033 17.4 0.0 0.011 15.7 0.0 1.9 1 0 0 1 1 1 1 U-box domain zf-RING_6 PF14835.4 001045270.2_16125001_2 - 0.0044 16.7 4.4 0.0044 16.7 4.4 2.5 3 0 0 3 3 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 001045270.2_16125001_2 - 0.0098 15.6 8.4 0.0098 15.6 8.4 3.8 4 0 0 4 4 3 1 Prokaryotic RING finger family 4 IncA PF04156.12 001045270.2_16125001_2 - 0.052 13.2 14.9 0.18 11.5 14.9 1.9 1 0 0 1 1 1 0 IncA protein AMP-binding_C_2 PF14535.4 001045270.2_16125001_2 - 0.052 13.7 0.3 0.26 11.5 0.4 2.1 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain Exonuc_VII_L PF02601.13 001045270.2_16125001_2 - 0.068 12.6 5.2 0.13 11.7 5.2 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.4 001045270.2_16125001_2 - 0.1 11.8 2.4 0.16 11.2 2.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF342 PF03961.11 001045270.2_16125001_2 - 2.1 6.7 5.7 26 3.1 3.8 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF342) KxDL PF10241.7 001045270.2_16125001_2 - 2.6 8.2 6.4 15 5.8 2.5 3.1 2 1 0 2 2 2 0 Uncharacterized conserved protein OmpH PF03938.12 001045270.2_16125001_2 - 2.9 7.7 7.3 6.8 6.5 7.3 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DBC1 PF14443.4 001145599.1_16129001_1 - 6.6e-51 171.3 0.0 2.5e-50 169.5 0.0 2.1 1 0 0 1 1 1 1 DBC1 S1-like PF14444.4 001145599.1_16129001_1 - 5.1e-31 106.4 0.8 8.9e-31 105.6 0.8 1.4 1 0 0 1 1 1 1 S1-like SAP PF02037.25 001145599.1_16129001_1 - 1.7e-10 40.2 1.7 4.5e-10 38.9 1.7 1.8 1 0 0 1 1 1 1 SAP domain ADIP PF11559.6 001145599.1_16129001_1 - 0.0024 17.8 8.9 0.0024 17.8 8.9 3.6 4 1 0 4 4 4 1 Afadin- and alpha -actinin-Binding Tautomerase_2 PF14552.4 001145599.1_16129001_1 - 0.04 13.9 0.1 0.13 12.2 0.0 1.8 2 0 0 2 2 2 0 Tautomerase enzyme Cytochrom_B558a PF05038.11 001145599.1_16129001_1 - 1.8 8.0 3.6 4.6 6.7 3.6 1.6 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit IL8 PF00048.18 001136248.2_16122001_3 - 2.8e-18 65.7 0.7 4.5e-18 65.0 0.7 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Trypsin PF00089.24 001126377.1_16124001_3 - 3.5e-68 229.6 0.1 5.7e-68 228.9 0.1 1.3 1 0 0 1 1 1 1 Trypsin SRCR_2 PF15494.4 001126377.1_16124001_3 - 3.3e-25 88.3 1.1 6.1e-25 87.5 1.1 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain DUF1986 PF09342.9 001126377.1_16124001_3 - 1.8e-07 31.4 0.5 3.7e-07 30.4 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) SRCR PF00530.16 001126377.1_16124001_3 - 4.9e-07 30.0 0.2 1.2e-06 28.8 0.2 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Trypsin_2 PF13365.4 001126377.1_16124001_3 - 1.1e-05 26.2 0.1 2.8e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 Trypsin-like peptidase domain Ldl_recept_a PF00057.16 001126377.1_16124001_3 - 0.001 19.1 0.9 0.001 19.1 0.9 1.8 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Hepsin-SRCR PF09272.8 001126377.1_16124001_3 - 0.008 16.3 0.2 0.016 15.4 0.2 1.4 1 0 0 1 1 1 1 Hepsin, SRCR HECT_2 PF09814.7 001126377.1_16124001_3 - 0.025 13.3 0.2 0.037 12.8 0.2 1.1 1 0 0 1 1 1 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding TF_Zn_Ribbon PF08271.10 001126377.1_16124001_3 - 0.041 13.3 1.5 0.09 12.2 1.5 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding TMEM223 PF14640.4 001126377.1_16124001_3 - 0.1 12.6 0.5 0.2 11.6 0.5 1.4 1 0 0 1 1 1 0 Transmembrane protein 223 LRR_8 PF13855.4 001145622.1_16123001_1 - 4.9e-30 102.9 32.2 5.3e-12 45.2 0.5 4.1 4 0 0 4 4 4 3 Leucine rich repeat LRR_4 PF12799.5 001145622.1_16123001_1 - 5.3e-24 83.7 25.4 6.3e-07 29.5 0.2 6.3 3 2 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001145622.1_16123001_1 - 6.4e-09 34.9 19.0 0.84 10.2 0.1 9.5 8 2 0 8 8 8 4 Leucine Rich Repeat LRR_9 PF14580.4 001145622.1_16123001_1 - 0.00086 18.7 12.5 0.2 11.0 1.8 3.2 1 1 2 3 3 3 3 Leucine-rich repeat Lectin_C PF00059.19 001100080.1_16123001_3 - 1.1e-48 164.3 28.4 6.1e-18 65.4 7.6 3.1 3 0 0 3 3 3 3 Lectin C-type domain Xlink PF00193.15 001100080.1_16123001_3 - 3.7e-05 23.9 0.5 1.5 9.1 0.0 3.6 3 0 0 3 3 3 3 Extracellular link domain DUF2726 PF10881.6 001100080.1_16123001_3 - 0.032 14.0 1.9 21 4.9 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2726) IF3_N PF05198.14 001100080.1_16123001_3 - 0.05 13.8 0.0 2.9 8.1 0.0 2.8 3 0 0 3 3 3 0 Translation initiation factor IF-3, N-terminal domain IQ PF00612.25 001123373.1_16129001_2 - 1.3e-130 412.9 556.7 3.4e-05 23.1 1.8 74.7 77 1 1 78 78 78 65 IQ calmodulin-binding motif ASH PF15780.3 001123373.1_16129001_2 - 3.6e-31 107.1 0.0 1.3e-30 105.3 0.0 2.1 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin CH PF00307.29 001123373.1_16129001_2 - 6.6e-15 55.1 1.5 8.8e-08 32.2 0.0 4.7 3 1 0 3 3 3 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001123373.1_16129001_2 - 0.00014 21.5 0.0 0.0012 18.5 0.0 2.6 2 0 0 2 2 2 1 CAMSAP CH domain DERM PF14704.4 001044836.1_16122001_1 - 4.2e-50 170.0 15.1 4.8e-50 169.8 15.1 1.0 1 0 0 1 1 1 1 Dermatopontin Acetate_kinase PF00871.15 001044836.1_16122001_1 - 0.0059 15.2 0.1 0.5 8.9 0.0 2.0 1 1 1 2 2 2 2 Acetokinase family ET PF01684.14 001044836.1_16122001_1 - 0.04 14.1 1.2 0.073 13.3 0.4 1.8 1 1 1 2 2 2 0 ET module Fer4_10 PF13237.4 001044836.1_16122001_1 - 0.77 9.8 6.5 0.096 12.7 1.6 1.9 3 0 0 3 3 3 0 4Fe-4S dicluster domain Sema PF01403.17 001045008.1_16125001_1 - 8.9e-142 472.7 0.0 1.2e-141 472.2 0.0 1.2 1 0 0 1 1 1 1 Sema domain PSI PF01437.23 001045008.1_16125001_1 - 1.6e-08 34.8 4.6 1.6e-08 34.8 4.6 1.9 2 0 0 2 2 2 1 Plexin repeat Ig_3 PF13927.4 001045008.1_16125001_1 - 8.8e-06 26.1 0.1 4.6e-05 23.8 0.0 2.3 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.4 001045008.1_16125001_1 - 9.6e-06 25.7 0.0 2.6e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001045008.1_16125001_1 - 9.6e-06 25.6 0.0 2.7e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001045008.1_16125001_1 - 0.00064 19.6 0.0 0.0015 18.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.15 001045008.1_16125001_1 - 0.11 12.5 4.3 0.6 10.2 0.1 3.3 3 1 1 4 4 4 0 Immunoglobulin V-set domain DUF2202 PF09968.7 001045008.1_16125001_1 - 0.15 11.7 0.1 0.37 10.5 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein domain (DUF2202) IBN_N PF03810.17 001128230.2_16129001_2 - 9.4e-13 47.8 0.1 5.3e-12 45.3 0.1 2.5 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.10 001128230.2_16129001_2 - 0.02 14.8 0.4 0.02 14.8 0.4 3.5 4 0 0 4 4 4 0 Exportin 1-like protein TSNAXIP1_N PF15739.3 001100100.1_16126001_1 - 3.9e-34 117.3 10.2 3.3e-32 111.1 5.7 3.2 2 0 0 2 2 2 2 Translin-associated factor X-interacting N-terminus HALZ PF02183.16 001100100.1_16126001_1 - 6.1e-05 23.0 2.6 0.024 14.7 0.4 3.3 2 0 0 2 2 2 2 Homeobox associated leucine zipper FlaC_arch PF05377.9 001100100.1_16126001_1 - 0.37 11.1 2.8 4.4 7.6 0.2 3.6 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF2205 PF10224.7 001100100.1_16126001_1 - 1.1 9.2 9.8 37 4.3 0.0 4.6 3 1 0 4 4 4 0 Predicted coiled-coil protein (DUF2205) Sema PF01403.17 001128352.1_16125001_1 - 7.7e-156 519.0 0.0 1.1e-155 518.5 0.0 1.2 1 0 0 1 1 1 1 Sema domain PSI PF01437.23 001128352.1_16125001_1 - 2.5e-06 27.8 10.7 2.5e-06 27.8 10.7 2.3 2 0 0 2 2 2 1 Plexin repeat zf-DHHC PF01529.18 001128352.1_16125001_1 - 0.51 10.3 3.1 3.7 7.5 1.7 2.6 2 0 0 2 2 2 0 DHHC palmitoyltransferase PSI_integrin PF17205.1 001128352.1_16125001_1 - 0.55 10.0 6.4 2 8.2 6.4 2.0 1 0 0 1 1 1 0 Integrin plexin domain UDPGT PF00201.16 001191050.1_16125001_3 - 2.5e-212 706.0 0.1 3.1e-212 705.7 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001191050.1_16125001_3 - 8.3e-07 29.0 0.0 1.4e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 001191050.1_16125001_3 - 0.059 13.2 0.0 0.3 10.9 0.0 2.0 1 1 0 1 1 1 0 Glycosyltransferase Family 4 DPM2 PF07297.10 001122846.2_16122001_2 - 9.4e-32 109.0 2.8 9.4e-32 109.0 2.8 1.7 2 0 0 2 2 2 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.10 001122846.2_16122001_2 - 0.035 13.9 1.3 0.035 13.9 1.3 1.8 2 0 0 2 2 2 0 PIG-P PC4 PF02229.14 001281998.1_16122001_1 - 0.0054 16.2 0.1 0.0086 15.6 0.1 1.3 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) QLQ PF08880.9 001281998.1_16122001_1 - 0.04 13.6 0.2 0.065 12.9 0.2 1.4 1 0 0 1 1 1 0 QLQ dCMP_cyt_deam_1 PF00383.21 001351715.1_16125001_2 - 5.2e-15 55.0 0.1 8.6e-15 54.3 0.1 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.10 001351715.1_16125001_2 - 1.6e-11 44.4 0.2 5.5e-09 36.2 0.1 2.2 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.4 001351715.1_16125001_2 - 0.008 15.7 1.3 0.087 12.3 0.2 2.1 1 1 1 2 2 2 1 A distinct subfamily of CDD/CDA-like deaminases Pkinase_Tyr PF07714.15 001030220.1_16124001_3 - 3.3e-96 321.4 0.0 4.3e-96 321.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001030220.1_16124001_3 - 7.4e-50 169.6 0.0 1.1e-49 169.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001030220.1_16124001_3 - 1e-24 86.3 0.0 2.2e-24 85.1 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001030220.1_16124001_3 - 9.2e-15 53.8 0.1 1.9e-14 52.9 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001030220.1_16124001_3 - 1.5e-09 37.5 0.0 3e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001030220.1_16124001_3 - 3.4e-09 36.1 0.0 8.2e-09 34.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Kdo PF06293.12 001030220.1_16124001_3 - 0.0096 15.2 0.3 0.018 14.2 0.3 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001030220.1_16124001_3 - 0.084 12.0 0.1 0.27 10.4 0.0 1.7 1 1 0 1 1 1 0 Kinase-like RIO1 PF01163.20 001030220.1_16124001_3 - 0.097 12.1 0.1 0.22 11.0 0.1 1.5 1 0 0 1 1 1 0 RIO1 family DUF4834 PF16118.3 001113656.1_16123001_1 - 0.13 13.1 0.7 0.28 12.0 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CCSMST1 PF15013.4 001113656.1_16123001_1 - 0.14 12.2 0.8 23 5.1 0.3 2.3 2 0 0 2 2 2 0 CCSMST1 family DAGK_acc PF00609.17 001172228.1_16124001_1 - 5.4e-50 169.7 0.0 7.6e-49 166.0 0.0 2.2 2 0 0 2 2 2 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 001172228.1_16124001_1 - 1.8e-21 76.0 0.0 3e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.20 001172228.1_16124001_1 - 6.2e-10 38.7 30.8 9.7e-07 28.4 8.2 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) HEAT PF02985.20 001145604.1_16127001_1 - 8.9e-22 75.1 8.9 6.1e-05 22.8 0.0 9.4 10 0 0 10 10 10 3 HEAT repeat HEAT_2 PF13646.4 001145604.1_16127001_1 - 1.7e-20 73.1 0.4 6.1e-09 36.0 0.0 7.8 5 3 2 7 7 7 3 HEAT repeats HEAT_EZ PF13513.4 001145604.1_16127001_1 - 2.2e-18 66.2 3.8 5.2e-08 33.1 0.0 8.2 8 2 1 9 9 9 3 HEAT-like repeat Vac14_Fab1_bd PF12755.5 001145604.1_16127001_1 - 1.4e-16 60.7 6.9 1.2e-06 28.9 0.0 8.3 6 2 3 9 9 9 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.5 001145604.1_16127001_1 - 2.9e-11 43.5 4.7 0.00014 21.8 0.1 4.9 3 2 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.6 001145604.1_16127001_1 - 9.8e-08 31.9 9.2 0.34 10.6 0.1 8.5 8 3 2 10 10 10 2 Domain of unknown function (DUF3385) IBN_N PF03810.17 001145604.1_16127001_1 - 0.00013 21.7 5.6 0.0013 18.4 0.1 4.6 5 0 0 5 5 5 1 Importin-beta N-terminal domain Cnd3 PF12719.5 001145604.1_16127001_1 - 0.00042 19.5 10.3 0.0049 16.0 0.0 3.8 4 1 1 5 5 5 2 Nuclear condensing complex subunits, C-term domain Tti2 PF10521.7 001145604.1_16127001_1 - 0.00086 18.8 0.2 8.5 5.7 0.0 4.8 3 2 1 4 4 4 1 Tti2 family Atx10homo_assoc PF09759.7 001145604.1_16127001_1 - 0.0017 18.3 0.6 4.3 7.3 0.1 4.0 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain Arm PF00514.21 001145604.1_16127001_1 - 0.011 15.6 5.3 24 5.0 0.0 6.6 8 0 0 8 8 7 0 Armadillo/beta-catenin-like repeat MMS19_C PF12460.6 001145604.1_16127001_1 - 0.014 14.4 7.0 5.1 6.0 0.1 4.7 3 2 1 4 4 4 0 RNAPII transcription regulator C-terminal RTP1_C1 PF10363.7 001145604.1_16127001_1 - 0.019 15.0 0.4 0.71 9.9 0.0 3.8 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Sec7_N PF12783.5 001145604.1_16127001_1 - 0.025 14.4 4.7 5.9 6.7 0.4 5.5 5 1 1 6 6 6 0 Guanine nucleotide exchange factor in Golgi transport N-terminal PBP1_TM PF14812.4 001145604.1_16127001_1 - 0.037 14.3 0.2 0.037 14.3 0.2 1.8 2 0 0 2 2 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RasGEF_N_2 PF14663.4 001145604.1_16127001_1 - 0.09 13.0 2.6 59 3.9 0.0 5.1 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF4042 PF13251.4 001145604.1_16127001_1 - 0.11 12.1 2.7 3.5 7.2 0.0 4.4 5 1 1 6 6 6 0 Domain of unknown function (DUF4042) HEAT_PBS PF03130.14 001145604.1_16127001_1 - 0.15 12.7 0.5 1e+02 3.9 0.0 4.5 5 0 0 5 5 3 0 PBS lyase HEAT-like repeat DUF445 PF04286.10 001145604.1_16127001_1 - 0.31 10.7 5.3 17 5.0 1.1 3.8 2 1 1 3 3 3 0 Protein of unknown function (DUF445) Phosducin PF02114.14 001291500.1_16126001_3 - 2.9e-100 334.5 0.3 4.2e-100 333.9 0.3 1.1 1 0 0 1 1 1 1 Phosducin Astacin PF01400.22 001077779.2_16123001_1 - 6e-56 188.9 0.2 9.3e-56 188.3 0.2 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.22 001077779.2_16123001_1 - 0.081 12.6 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Matrixin DUF809 PF05663.9 001077779.2_16123001_1 - 0.33 11.0 7.5 0.035 14.1 2.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF809) LIP1 PF15904.3 200288.2_16127001_2 - 5.8e-43 145.0 4.0 2.1e-42 143.2 3.0 2.5 2 0 0 2 2 2 1 LKB1 serine/threonine kinase interacting protein 1 LRR_8 PF13855.4 200288.2_16127001_2 - 7.3e-10 38.3 25.2 2.3e-05 23.9 2.7 4.6 3 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.5 200288.2_16127001_2 - 5.4e-08 32.8 26.0 0.0017 18.5 3.7 5.0 3 3 2 6 6 6 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 200288.2_16127001_2 - 0.00046 19.6 7.2 0.15 11.5 2.8 2.5 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.4 200288.2_16127001_2 - 0.38 10.8 14.2 18 5.5 0.1 6.0 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.31 200288.2_16127001_2 - 9.4 7.0 19.8 34 5.3 0.0 6.9 5 1 0 5 5 5 0 Leucine Rich Repeat SPRY PF00622.26 001122707.1_16123001_1 - 1.9e-14 53.7 1.4 1.9e-14 53.7 0.1 1.7 2 0 0 2 2 2 1 SPRY domain PRY PF13765.4 001122707.1_16123001_1 - 7.8e-10 38.1 0.1 4.5e-09 35.6 0.0 2.3 2 1 0 2 2 2 1 SPRY-associated domain DUF1754 PF08555.8 001122707.1_16123001_1 - 0.063 14.0 4.2 0.14 12.9 4.2 1.5 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) 7tm_1 PF00001.19 001083102.1_16123001_3 - 6.2e-63 212.4 17.8 8.7e-63 211.9 17.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001083102.1_16123001_3 - 2.5e-11 43.3 20.7 3.2e-11 43.0 20.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001083102.1_16123001_3 - 0.00018 20.8 14.6 0.00018 20.8 14.6 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001083102.1_16123001_3 - 0.0021 17.7 13.9 0.012 15.2 13.9 2.0 1 1 0 1 1 1 1 Olfactory receptor Ank_2 PF12796.5 001126376.1_16124001_2 - 6.9e-21 74.5 0.6 2e-08 34.6 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 001126376.1_16124001_2 - 1.5e-16 59.9 4.8 0.0002 21.6 0.2 5.9 5 1 1 6 6 6 4 Ankyrin repeat Ank_3 PF13606.4 001126376.1_16124001_2 - 3.4e-16 57.6 1.9 0.0093 16.3 0.0 6.3 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.4 001126376.1_16124001_2 - 2e-15 56.8 1.8 4.5e-07 30.2 0.2 5.2 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 001126376.1_16124001_2 - 7e-15 54.8 0.5 4.3e-05 23.6 0.1 4.3 3 1 0 4 4 4 3 Ankyrin repeats (many copies) SOCS_box PF07525.14 001126376.1_16124001_2 - 1e-08 35.2 2.7 3e-08 33.7 2.7 1.9 1 0 0 1 1 1 1 SOCS box Ion_trans_2 PF07885.14 001128549.1_16123001_1 - 1.7e-36 123.9 16.6 2.3e-18 65.8 0.4 2.9 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.29 001128549.1_16123001_1 - 3.3e-07 29.7 5.5 0.013 14.6 0.0 2.2 1 1 0 2 2 2 2 Ion transport protein DUF2101 PF09874.7 001128549.1_16123001_1 - 0.95 9.0 5.0 12 5.4 1.7 2.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2101) DUF4551 PF15087.4 001100059.1_16121001_1 - 0.19 10.4 4.8 0.21 10.3 4.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) TFIIF_alpha PF05793.10 001100059.1_16121001_1 - 3 6.2 13.3 3.8 5.9 13.3 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF1387 PF07139.9 001100059.1_16121001_1 - 4.3 6.8 11.0 5.1 6.6 11.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Apt1 PF10351.7 001100059.1_16121001_1 - 5 5.7 9.2 5.6 5.6 9.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Sulfotransfer_1 PF00685.25 001082875.1_16123001_1 - 8.2e-67 225.3 0.1 1e-66 225.0 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001082875.1_16123001_1 - 6.5e-08 33.1 0.0 4.4e-05 23.8 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family SpoVIF PF14069.4 001082875.1_16123001_1 - 0.14 11.8 0.3 0.31 10.7 0.3 1.5 1 0 0 1 1 1 0 Stage VI sporulation protein F Toxin_13 PF07822.9 001082875.1_16123001_2 - 0.053 13.5 0.1 0.12 12.4 0.0 1.6 2 0 0 2 2 2 0 Neurotoxin B-IV-like protein Glyco_hydro_1 PF00232.16 001100014.2_16124001_1 - 1.2e-161 538.1 9.3 1.4e-161 537.9 9.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 DUF3377 PF11857.6 001100014.2_16124001_1 - 0.04 13.7 0.2 0.1 12.4 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Glyco_hydro_10 PF00331.18 001100014.2_16124001_1 - 0.081 11.9 0.0 0.081 11.9 0.0 2.5 3 0 0 3 3 3 0 Glycosyl hydrolase family 10 Tetraspannin PF00335.18 001045135.1_16122001_1 - 4.1e-58 196.5 9.1 4.6e-58 196.3 9.1 1.0 1 0 0 1 1 1 1 Tetraspanin family ATP-synt_8 PF00895.18 001045135.1_16122001_1 - 4.2 7.8 7.0 29 5.1 0.7 2.8 2 0 0 2 2 2 0 ATP synthase protein 8 OATP PF03137.18 212917.3_16125001_2 - 5.7e-148 493.5 9.5 7e-148 493.2 9.5 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 212917.3_16125001_2 - 4.4e-22 78.4 21.8 4.7e-22 78.3 14.8 3.0 2 1 0 2 2 2 1 Major Facilitator Superfamily Kazal_2 PF07648.13 212917.3_16125001_2 - 8.7e-12 44.9 4.4 1.7e-11 43.9 4.4 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 212917.3_16125001_2 - 0.0011 18.8 7.2 0.0025 17.6 7.2 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain SMC_N PF02463.17 001128334.1_16128001_1 - 1.2e-23 83.6 0.2 3.2e-23 82.2 0.2 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.4 001128334.1_16128001_1 - 2.7e-17 63.8 1.9 2.7e-17 63.8 1.9 5.4 3 2 0 3 3 1 1 AAA domain Spc7 PF08317.9 001128334.1_16128001_1 - 6.1e-07 28.5 99.7 0.057 12.2 21.9 5.2 2 2 4 6 6 6 5 Spc7 kinetochore protein Laminin_II PF06009.10 001128334.1_16128001_1 - 5.5e-06 26.3 10.0 5.5e-06 26.3 10.0 6.6 3 2 3 6 6 6 3 Laminin Domain II AAA_21 PF13304.4 001128334.1_16128001_1 - 7.2e-06 25.9 8.7 0.0099 15.6 0.1 3.4 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system Syntaxin_2 PF14523.4 001128334.1_16128001_1 - 0.00039 20.6 0.7 0.00039 20.6 0.7 6.8 3 2 3 6 6 5 1 Syntaxin-like protein Reo_sigmaC PF04582.10 001128334.1_16128001_1 - 0.00064 19.1 19.3 0.002 17.5 3.3 4.2 2 2 1 4 4 4 2 Reovirus sigma C capsid protein TMF_TATA_bd PF12325.6 001128334.1_16128001_1 - 0.0011 19.0 5.3 0.0011 19.0 5.3 7.4 2 2 4 7 7 7 1 TATA element modulatory factor 1 TATA binding AAA_29 PF13555.4 001128334.1_16128001_1 - 0.0017 17.9 0.6 0.0033 17.0 0.6 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.4 001128334.1_16128001_1 - 0.002 16.8 76.9 0.021 13.4 26.4 4.5 3 1 1 4 4 4 3 AAA domain IncA PF04156.12 001128334.1_16128001_1 - 0.0023 17.6 21.5 0.0023 17.6 21.5 6.2 2 2 4 6 6 6 3 IncA protein AAA_15 PF13175.4 001128334.1_16128001_1 - 0.0025 17.3 23.7 0.0025 17.3 23.7 3.9 2 2 1 3 3 2 1 AAA ATPase domain DUF1664 PF07889.10 001128334.1_16128001_1 - 0.039 13.8 63.0 0.051 13.4 7.6 7.8 2 2 7 10 10 10 0 Protein of unknown function (DUF1664) ATG16 PF08614.9 001128334.1_16128001_1 - 0.23 11.5 99.1 0.11 12.6 20.6 6.0 2 2 4 6 6 6 0 Autophagy protein 16 (ATG16) DUF812 PF05667.9 001128334.1_16128001_1 - 0.29 9.9 99.5 2.9 6.6 41.5 3.9 2 2 2 4 4 4 0 Protein of unknown function (DUF812) APG6 PF04111.10 001128334.1_16128001_1 - 0.81 8.9 102.7 1.6 7.9 23.8 5.3 2 2 3 5 5 5 0 Autophagy protein Apg6 TPR_MLP1_2 PF07926.10 001128334.1_16128001_1 - 1.1 9.2 110.4 1.3 8.9 20.9 6.9 2 2 3 6 6 6 0 TPR/MLP1/MLP2-like protein Clr5 PF14420.4 001128334.1_16128001_1 - 1.3 9.2 4.5 0.68 10.1 0.4 2.8 2 0 0 2 2 2 0 Clr5 domain DUF3584 PF12128.6 001128334.1_16128001_1 - 3.5 4.9 91.8 0.022 12.2 40.9 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3584) DUF948 PF06103.9 001128334.1_16128001_1 - 3.6 7.8 28.0 2.1 8.5 0.0 6.7 3 3 3 7 7 7 0 Bacterial protein of unknown function (DUF948) IFT57 PF10498.7 001128334.1_16128001_1 - 4.1 6.2 88.2 0.0081 15.0 17.5 6.1 2 2 3 6 6 6 0 Intra-flagellar transport protein 57 Tannase PF07519.9 001128334.1_16128001_1 - 4.2 6.0 6.0 1.6 7.4 2.9 1.8 2 0 0 2 2 2 0 Tannase and feruloyl esterase GAS PF13851.4 001128334.1_16128001_1 - 5.1 6.3 106.8 0.16 11.2 10.4 6.4 2 2 5 7 7 7 0 Growth-arrest specific micro-tubule binding MCPsignal PF00015.19 001128334.1_16128001_1 - 7.6 6.1 38.6 0.029 14.0 6.1 5.0 2 2 3 5 5 5 0 Methyl-accepting chemotaxis protein (MCP) signalling domain FAM163 PF15069.4 001099429.1_16122001_3 - 2.2e-32 112.7 13.5 1.1e-25 90.9 6.9 2.2 1 1 1 2 2 2 2 FAM163 family DUF4006 PF13179.4 001099429.1_16122001_3 - 0.43 10.4 2.4 0.91 9.4 2.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF4006) HCV_NS4a PF01006.18 001099429.1_16122001_3 - 0.67 9.6 4.3 1.2 8.8 4.3 1.4 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS4a RasGEF PF00617.17 001044862.1_16127001_1 - 3.4e-43 147.7 0.1 7.3e-43 146.6 0.1 1.6 1 0 0 1 1 1 1 RasGEF domain C1_1 PF00130.20 001044862.1_16127001_1 - 9.8e-13 47.7 12.0 2.5e-12 46.4 12.0 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_7 PF13499.4 001044862.1_16127001_1 - 6.6e-05 23.2 0.0 0.0027 18.0 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.30 001044862.1_16127001_1 - 0.00019 20.6 0.3 0.00019 20.6 0.3 2.8 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.4 001044862.1_16127001_1 - 0.0009 18.5 3.1 0.0018 17.6 0.1 2.7 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.4 001044862.1_16127001_1 - 0.0053 16.5 0.0 0.091 12.6 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.4 001044862.1_16127001_1 - 0.12 12.1 0.7 0.32 10.7 0.2 2.0 2 0 0 2 2 2 0 EF-hand domain pair C1_2 PF03107.14 001044862.1_16127001_1 - 0.9 9.8 9.8 2.2 8.5 9.8 1.7 1 0 0 1 1 1 0 C1 domain OrfB_Zn_ribbon PF07282.9 001044862.1_16127001_1 - 4.7 7.1 9.1 1.9 8.3 0.1 2.8 2 0 0 2 2 2 0 Putative transposase DNA-binding domain CCDC71L PF15374.4 001044710.1_16126001_2 - 9.7e-60 202.7 2.3 2.6e-41 142.1 0.2 2.1 2 0 0 2 2 2 2 Coiled-coil domain-containing protein 71L Kinesin PF00225.21 001044976.1_16129001_2 - 8.4e-108 360.1 2.8 8.4e-108 360.1 2.8 2.1 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.3 001044976.1_16129001_2 - 1.9e-24 86.2 0.6 6.2e-24 84.5 0.6 2.0 1 0 0 1 1 1 1 Microtubule binding Kinesin_assoc PF16183.3 001044976.1_16129001_2 - 1.4e-14 54.5 23.6 8.4e-11 42.2 2.5 4.7 3 2 1 4 4 4 2 Kinesin-associated FHA PF00498.24 001044976.1_16129001_2 - 3e-07 30.5 1.3 1.5e-06 28.3 0.1 2.6 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.3 001044976.1_16129001_2 - 0.0076 16.4 0.3 0.033 14.4 0.0 2.2 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain SSrecog PF03531.12 212802.2_16126001_1 - 1.7e-89 298.7 0.0 9.9e-89 296.3 0.0 2.1 2 0 0 2 2 2 1 Structure-specific recognition protein (SSRP1) HMG_box PF00505.17 212802.2_16126001_1 - 1.1e-25 89.7 7.8 3.7e-25 88.0 7.8 2.0 1 0 0 1 1 1 1 HMG (high mobility group) box Rtt106 PF08512.10 212802.2_16126001_1 - 1.4e-25 89.4 0.7 3.4e-25 88.1 0.1 2.0 2 0 0 2 2 2 1 Histone chaperone Rttp106-like HMG_box_2 PF09011.8 212802.2_16126001_1 - 4.8e-12 46.2 7.0 1.4e-11 44.7 7.0 1.9 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.11 212802.2_16126001_1 - 1.1 9.6 9.9 0.068 13.6 3.6 2.1 1 1 1 2 2 2 0 YABBY protein Armet PF10208.7 001123281.1_16124001_3 - 4.1e-59 198.6 0.1 5.5e-59 198.2 0.1 1.1 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding FOP_dimer PF09398.8 001326495.1_16122001_1 - 3.1e-22 78.5 2.1 9.3e-22 77.0 0.1 2.1 2 0 0 2 2 2 1 FOP N terminal dimerisation domain LisH_2 PF16045.3 001326495.1_16122001_1 - 1.3e-06 27.2 0.0 2.5e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 LisH Phtf-FEM1B_bdg PF12129.6 001326495.1_16122001_3 - 0.072 12.8 2.9 0.11 12.2 2.9 1.2 1 0 0 1 1 1 0 Male germ-cell putative homeodomain transcription factor C1-set PF07654.13 001327913.1_16124001_1 - 1.1e-14 54.5 0.0 3.6e-14 52.9 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_2 PF13895.4 001328049.1_16122001_1 - 0.0089 16.2 1.6 0.032 14.4 1.6 2.0 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001328049.1_16122001_1 - 0.01 15.7 0.1 0.99 9.4 0.1 2.4 2 0 0 2 2 2 0 Immunoglobulin I-set domain V-set PF07686.15 001328049.1_16122001_1 - 0.013 15.5 1.7 0.041 13.9 1.7 1.8 1 1 0 1 1 1 0 Immunoglobulin V-set domain DUF2207 PF09972.7 001328049.1_16122001_1 - 0.065 11.9 0.0 0.096 11.3 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ig_3 PF13927.4 001328049.1_16122001_1 - 0.12 12.8 3.1 0.19 12.2 1.3 2.3 2 1 0 2 2 2 0 Immunoglobulin domain ig PF00047.23 001328049.1_16122001_1 - 0.14 12.2 4.3 0.18 11.9 2.4 2.2 2 0 0 2 2 2 0 Immunoglobulin domain Rad21_Rec8_N PF04825.11 001045120.2_16124001_1 - 1.5e-40 137.7 0.0 2.8e-40 136.8 0.0 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.14 001045120.2_16124001_1 - 2.3e-20 71.5 0.1 1e-19 69.4 0.1 2.2 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein SMC_ScpA PF02616.12 001045120.2_16124001_1 - 0.00033 20.5 0.0 0.00067 19.5 0.0 1.5 1 0 0 1 1 1 1 Segregation and condensation protein ScpA CobT PF06213.10 001045120.2_16124001_1 - 0.0057 15.9 4.4 0.01 15.1 4.4 1.3 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT Kunitz_BPTI PF00014.21 001044894.1_16123001_1 - 1.7e-19 69.6 3.9 2.5e-19 69.1 3.9 1.2 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Lectin_C PF00059.19 001328043.1_16123001_2 - 3.3e-40 137.0 24.8 7.5e-17 61.9 2.8 3.3 3 0 0 3 3 3 3 Lectin C-type domain Xlink PF00193.15 001328043.1_16123001_2 - 0.00018 21.7 0.3 3.7 7.9 0.0 3.5 3 0 0 3 3 3 3 Extracellular link domain IF3_N PF05198.14 001328043.1_16123001_2 - 0.0062 16.6 0.1 2.4 8.4 0.1 2.9 3 0 0 3 3 3 2 Translation initiation factor IF-3, N-terminal domain ESCRT-II PF05871.10 001328043.1_16123001_2 - 0.57 10.2 4.0 4.7 7.3 0.2 2.9 3 0 0 3 3 3 0 ESCRT-II complex subunit Peptidase_M17 PF00883.19 001114847.1_16125001_1 - 3.8e-124 413.9 0.1 4.8e-124 413.5 0.1 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.15 001114847.1_16125001_1 - 1.8e-18 66.4 0.0 3.7e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain DUF2358 PF10184.7 001082846.1_16124001_3 - 1.1e-31 109.3 0.4 1.6e-31 108.7 0.4 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) Spt20 PF12090.6 001034974.4_16125001_1 - 1 8.8 3.5 1.5 8.2 3.5 1.1 1 0 0 1 1 1 0 Spt20 family LRRFIP PF09738.7 001034974.4_16125001_2 - 4.6e-105 351.3 35.3 4.6e-105 351.3 35.3 2.6 2 1 0 2 2 2 1 LRRFIP family KASH_CCD PF14662.4 001034974.4_16125001_2 - 0.0083 15.9 16.1 0.0083 15.9 16.1 3.6 3 1 1 4 4 4 2 Coiled-coil region of CCDC155 or KASH Syntaxin-6_N PF09177.9 001034974.4_16125001_2 - 0.022 15.2 4.5 0.022 15.2 4.5 4.0 3 2 1 4 4 4 0 Syntaxin 6, N-terminal DUF1664 PF07889.10 001034974.4_16125001_2 - 0.031 14.1 31.3 0.3 11.0 0.5 4.5 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) BRE1 PF08647.9 001034974.4_16125001_2 - 0.25 11.3 48.2 0.039 13.9 15.7 4.3 3 1 1 4 4 4 0 BRE1 E3 ubiquitin ligase DUF3450 PF11932.6 001034974.4_16125001_2 - 0.38 9.9 44.1 0.032 13.4 9.4 4.1 3 1 1 4 4 4 0 Protein of unknown function (DUF3450) CALCOCO1 PF07888.9 001034974.4_16125001_2 - 0.53 8.7 52.4 0.066 11.7 14.8 3.0 3 0 0 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like Fez1 PF06818.13 001034974.4_16125001_2 - 0.77 10.0 48.6 0.027 14.8 18.4 3.3 2 1 0 3 3 3 0 Fez1 Reo_sigmaC PF04582.10 001034974.4_16125001_2 - 0.98 8.6 10.0 0.46 9.7 0.5 2.8 3 1 1 4 4 4 0 Reovirus sigma C capsid protein AAA_13 PF13166.4 001034974.4_16125001_2 - 1.4 7.4 38.8 0.084 11.4 9.7 2.9 2 1 0 3 3 3 0 AAA domain APG6 PF04111.10 001034974.4_16125001_2 - 2.3 7.4 53.5 1.5 8.0 15.5 3.4 3 1 0 3 3 3 0 Autophagy protein Apg6 MAD PF05557.11 001034974.4_16125001_2 - 2.4 6.3 55.5 0.18 10.0 16.0 2.9 3 0 0 3 3 3 0 Mitotic checkpoint protein DUF16 PF01519.14 001034974.4_16125001_2 - 2.9 8.3 33.4 1.2 9.5 8.8 4.2 3 1 0 4 4 4 0 Protein of unknown function DUF16 Spc7 PF08317.9 001034974.4_16125001_2 - 3.1 6.4 50.7 0.26 10.0 1.6 4.1 3 1 1 4 4 4 0 Spc7 kinetochore protein NPV_P10 PF05531.10 001034974.4_16125001_2 - 3.3 8.1 14.9 0.15 12.5 0.8 3.7 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF724 PF05266.12 001034974.4_16125001_2 - 3.4 7.3 48.9 0.14 11.9 11.3 4.2 3 1 1 4 4 4 0 Protein of unknown function (DUF724) Laminin_II PF06009.10 001034974.4_16125001_2 - 6.3 6.7 34.7 0.069 13.0 9.5 4.3 4 1 0 4 4 4 0 Laminin Domain II V_ATPase_I PF01496.17 001034974.4_16125001_2 - 7.9 4.1 28.7 0.13 10.0 5.9 2.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family EzrA PF06160.10 001034974.4_16125001_2 - 10 4.1 41.6 0.069 11.2 10.9 3.4 3 1 0 3 3 3 0 Septation ring formation regulator, EzrA EF-hand_1 PF00036.30 001030268.2_16124001_1 - 5.3e-29 97.4 14.4 1.9e-09 36.2 0.1 4.6 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 001030268.2_16124001_1 - 6.6e-23 78.5 6.0 6.4e-08 31.8 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.4 001030268.2_16124001_1 - 4.7e-22 78.1 9.0 2.6e-15 56.5 1.3 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 001030268.2_16124001_1 - 1e-19 69.9 12.2 2.2e-11 43.2 0.8 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 001030268.2_16124001_1 - 3.2e-18 64.2 11.8 3.3e-07 29.4 0.2 4.0 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.4 001030268.2_16124001_1 - 2e-06 27.9 0.1 0.072 13.3 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain OST-HTH PF12872.5 001030268.2_16124001_1 - 0.0038 17.0 0.0 0.014 15.2 0.0 1.9 2 0 0 2 2 2 1 OST-HTH/LOTUS domain EF-hand_4 PF12763.5 001030268.2_16124001_1 - 0.018 14.8 0.4 0.1 12.4 0.1 2.1 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 001030268.2_16124001_1 - 0.022 14.9 4.0 0.09 13.0 0.0 2.8 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.11 001030268.2_16124001_1 - 0.083 12.7 0.4 3.2 7.6 0.0 2.5 2 1 0 2 2 2 0 Tellurite resistance protein TerB DIMCO_N PF16844.3 001030268.2_16124001_1 - 0.13 12.4 0.2 0.4 10.9 0.0 1.8 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor, N-terminal zf-U11-48K PF05253.10 001115142.1_16123001_2 - 9.7e-10 38.0 1.1 2.6e-09 36.7 1.1 1.8 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger DUF1509 PF07420.9 001115142.1_16123001_2 - 2.2 7.0 11.9 3 6.6 11.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) NACHT PF05729.10 001144051.1_16125001_3 - 1.7e-32 112.5 0.5 1.4e-31 109.5 0.0 2.7 3 0 0 3 3 3 1 NACHT domain FISNA PF14484.4 001144051.1_16125001_3 - 1.1e-28 99.1 1.7 1.1e-28 99.1 1.7 2.8 2 0 0 2 2 2 1 Fish-specific NACHT associated domain PYRIN PF02758.14 001144051.1_16125001_3 - 0.016 15.2 10.1 5.5 7.1 0.0 4.8 3 2 2 5 5 5 0 PAAD/DAPIN/Pyrin domain Popeye PF04831.11 001144051.1_16125001_3 - 0.029 14.4 0.9 0.25 11.4 0.1 2.3 2 0 0 2 2 2 0 Popeye protein conserved region IL28A PF15177.4 001144051.1_16125001_3 - 0.075 12.7 2.6 0.083 12.6 0.2 2.2 2 0 0 2 2 2 0 Interleukin-28A RHSP PF07999.9 001144051.1_16125001_3 - 0.091 11.4 0.0 0.15 10.7 0.0 1.2 1 0 0 1 1 1 0 Retrotransposon hot spot protein AAA_16 PF13191.4 001144051.1_16125001_3 - 0.097 12.9 1.6 1 9.6 0.0 3.3 3 1 0 3 3 3 0 AAA ATPase domain p450 PF00067.20 001044309.2_16124001_2 - 1.9e-09 36.7 0.0 2.2e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.20 001044309.2_16124001_3 - 5.4e-95 318.7 0.0 6.6e-95 318.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FTO_CTD PF12934.5 001044309.2_16124001_3 - 0.05 13.2 0.2 1.6 8.3 0.0 2.3 2 0 0 2 2 2 0 FTO C-terminal domain RhoGEF PF00621.18 001099980.1_16128001_1 - 1e-38 133.2 3.4 2.1e-38 132.2 1.6 2.3 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.27 001099980.1_16128001_1 - 9.3e-20 71.0 0.2 7.5e-09 35.9 0.1 2.7 2 0 0 2 2 2 2 PH domain FYVE PF01363.19 001099980.1_16128001_1 - 6.3e-18 64.5 12.1 2.7e-17 62.5 11.7 2.3 2 0 0 2 2 2 1 FYVE zinc finger PH_13 PF16652.3 001099980.1_16128001_1 - 4e-07 29.9 1.5 0.00043 20.1 1.8 3.5 2 1 0 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.3 001099980.1_16128001_1 - 7.8e-05 22.6 0.1 0.00016 21.5 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 001099980.1_16128001_1 - 0.0022 18.3 6.2 0.34 11.2 1.8 4.2 3 1 0 3 3 3 1 Pleckstrin homology domain FYVE_2 PF02318.14 001099980.1_16128001_1 - 0.02 15.0 10.5 0.063 13.4 10.5 1.8 1 0 0 1 1 1 0 FYVE-type zinc finger PH_9 PF15410.4 001099980.1_16128001_1 - 0.08 13.2 2.2 8.5 6.6 0.6 3.4 2 1 0 2 2 2 0 Pleckstrin homology domain Glyco_tranf_2_3 PF13641.4 001164030.1_16124001_1 - 1.8e-17 63.9 0.0 2.6e-13 50.3 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.13 001164030.1_16124001_1 - 9.6e-14 50.8 1.4 1.3e-08 33.8 1.2 3.3 2 1 0 2 2 2 2 Chitin synthase Glycos_transf_2 PF00535.24 001164030.1_16124001_1 - 3.9e-07 29.9 0.0 0.00051 19.7 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.4 001164030.1_16124001_1 - 0.00041 20.2 19.3 0.00041 20.2 19.3 2.7 2 1 0 2 2 2 1 Glycosyl transferase family group 2 RNA_pol_3_Rpc31 PF11705.6 001126469.1_16122001_3 - 4.2e-30 105.6 21.6 5.8e-30 105.1 21.6 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Nucleo_P87 PF07267.9 001126469.1_16122001_3 - 0.17 10.6 5.4 0.17 10.5 5.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF4746 PF15928.3 001126469.1_16122001_3 - 0.28 10.4 12.9 0.35 10.1 12.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) APG6 PF04111.10 001126469.1_16122001_3 - 3.7 6.7 10.2 4.8 6.4 10.2 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Hid1 PF12722.5 001126469.1_16122001_3 - 3.9 5.3 5.7 4.6 5.1 5.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ras PF00071.20 001082804.1_16122001_3 - 2.8e-57 192.7 0.0 3.2e-57 192.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001082804.1_16122001_3 - 2.9e-23 82.2 0.0 4.3e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001082804.1_16122001_3 - 9.7e-12 44.6 0.0 1.3e-11 44.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DAP3 PF10236.7 001082804.1_16122001_3 - 0.03 13.4 0.0 0.038 13.0 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Gtr1_RagA PF04670.10 001082804.1_16122001_3 - 0.062 12.5 0.0 0.09 12.0 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF498 PF04430.12 001082804.1_16122001_3 - 0.1 12.5 0.0 0.22 11.5 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF498/DUF598) Lectin_C PF00059.19 001100071.1_16123001_3 - 1.1e-37 128.9 31.9 5.8e-14 52.6 9.6 3.0 3 0 0 3 3 3 3 Lectin C-type domain UL45 PF05473.10 001100071.1_16123001_3 - 0.00012 21.7 0.8 0.0025 17.3 0.3 2.3 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like Xlink PF00193.15 001100071.1_16123001_3 - 0.0056 16.9 4.8 2.1 8.6 0.0 4.0 3 1 0 3 3 3 1 Extracellular link domain DUF2726 PF10881.6 001100071.1_16123001_3 - 0.02 14.6 2.0 4.1 7.2 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2726) IF3_N PF05198.14 001100071.1_16123001_3 - 0.038 14.1 0.2 4.5 7.5 0.1 2.9 3 0 0 3 3 3 0 Translation initiation factor IF-3, N-terminal domain zf-C2H2 PF00096.24 001146014.1_16129001_3 - 7.9e-35 117.3 74.2 1.8e-05 24.8 0.2 10.4 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001146014.1_16129001_3 - 7.7e-33 110.2 72.7 0.00012 22.5 0.4 10.7 10 0 0 10 10 10 9 C2H2-type zinc finger zf-met PF12874.5 001146014.1_16129001_3 - 2e-27 94.6 52.7 0.00036 20.7 0.6 9.8 9 0 0 9 9 9 8 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 001146014.1_16129001_3 - 2.3e-24 84.6 66.8 2.4e-07 30.8 1.2 11.5 12 0 0 12 12 12 6 Zinc-finger double domain zf-C2H2_jaz PF12171.6 001146014.1_16129001_3 - 3.9e-24 84.3 36.7 0.00035 20.7 0.9 9.4 9 0 0 9 9 9 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001146014.1_16129001_3 - 3.1e-07 30.0 62.6 0.19 11.6 1.8 10.1 10 0 0 10 10 10 7 C2H2-type zinc finger DUF3268 PF11672.6 001146014.1_16129001_3 - 0.00015 22.0 15.2 0.61 10.3 0.5 4.3 4 0 0 4 4 4 3 zinc-finger-containing domain zf-Di19 PF05605.10 001146014.1_16129001_3 - 0.0013 18.8 34.9 0.071 13.3 2.5 5.5 5 0 0 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.3 001146014.1_16129001_3 - 0.03 13.9 50.1 0.65 9.7 0.2 8.8 9 0 0 9 9 8 0 zinc-finger C2H2-type BolA PF01722.16 001146014.1_16129001_3 - 0.071 13.3 7.2 3.1 8.0 0.1 4.4 4 0 0 4 4 4 0 BolA-like protein dsrm PF00035.24 001146014.1_16129001_3 - 0.11 13.1 0.6 0.48 11.0 0.0 2.4 3 0 0 3 3 1 0 Double-stranded RNA binding motif zf-C2H2_9 PF16293.3 001146014.1_16129001_3 - 0.13 12.0 5.6 9.4 6.0 0.2 4.5 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.5 001146014.1_16129001_3 - 0.55 10.5 49.5 0.36 11.1 0.8 9.2 5 4 5 10 10 9 0 C2H2 type zinc-finger (2 copies) DUF3449 PF11931.6 001146014.1_16129001_3 - 1.7 8.2 7.6 1.6 8.3 0.3 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF3449) zf-C2HC_2 PF13913.4 001146014.1_16129001_3 - 4.6 7.1 48.6 0.82 9.5 0.1 8.7 9 0 0 9 9 8 0 zinc-finger of a C2HC-type PRKCSH_1 PF13015.4 001002057.2_16123001_1 - 1.1e-09 38.0 0.1 2e-09 37.2 0.1 1.4 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.11 001002057.2_16123001_1 - 3.4e-07 31.0 2.5 8.9e-07 29.7 2.5 1.7 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein SurA_N PF09312.9 001002057.2_16123001_1 - 0.21 11.5 3.5 0.064 13.2 0.8 1.5 2 0 0 2 2 2 0 SurA N-terminal domain LRAT PF04970.11 001201411.1_16122001_1 - 1.6e-38 131.8 0.0 2.1e-38 131.4 0.0 1.1 1 0 0 1 1 1 1 Lecithin retinol acyltransferase NLPC_P60 PF00877.17 001201411.1_16122001_1 - 0.0051 16.7 0.0 0.0087 15.9 0.0 1.3 1 0 0 1 1 1 1 NlpC/P60 family G-patch PF01585.21 001328037.1_16129001_3 - 7.8e-13 48.0 1.3 7.8e-13 48.0 1.3 2.1 2 0 0 2 2 2 1 G-patch domain zf-C2H2_jaz PF12171.6 001328037.1_16129001_3 - 1.7e-06 28.0 8.8 1.7e-06 28.0 8.8 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding G-patch_2 PF12656.5 001328037.1_16129001_3 - 0.013 15.5 0.2 0.013 15.5 0.2 2.7 3 0 0 3 3 3 0 G-patch domain zf-met PF12874.5 001328037.1_16129001_3 - 0.014 15.6 1.6 0.043 14.1 1.6 1.9 1 0 0 1 1 1 0 Zinc-finger of C2H2 type rve PF00665.24 001327894.1_16125001_2 - 1.3e-08 35.0 0.0 2.1e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DUF601 PF04642.10 001327894.1_16125001_2 - 0.053 12.9 0.6 0.077 12.3 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF601 DHR-2 PF06920.11 001166228.1_16129001_1 - 1.6e-108 363.6 11.1 4.7e-108 362.0 7.7 2.7 2 1 0 2 2 2 1 Dock homology region 2 DOCK_N PF16172.3 001166228.1_16129001_1 - 1.5e-107 359.7 0.9 2.8e-107 358.8 0.2 1.9 2 0 0 2 2 2 1 DOCK N-terminus DOCK-C2 PF14429.4 001166228.1_16129001_1 - 1.5e-52 178.1 0.0 5e-52 176.4 0.0 2.0 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins GCIP PF13324.4 001166228.1_16129001_1 - 0.0028 17.2 0.0 0.0071 15.9 0.0 1.6 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting SH3_1 PF00018.26 001166228.1_16129001_1 - 0.005 16.3 0.0 0.0098 15.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain TNFR_c6 PF00020.16 001123303.1_16123001_1 - 4.8e-15 55.6 41.3 2.1e-08 34.3 8.3 4.8 4 0 0 4 4 4 3 TNFR/NGFR cysteine-rich region DUF4366 PF14283.4 001123303.1_16123001_1 - 0.11 11.9 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) FAM117 PF15388.4 001128362.1_16124001_1 - 2.5e-113 378.4 17.1 2.5e-113 378.4 17.1 3.2 2 1 0 2 2 2 1 Protein Family FAM117 Phosphorylase PF00343.18 001328031.1_16127001_1 - 0 1156.6 0.0 0 1156.4 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase COX_ARM PF06481.12 001328031.1_16127001_1 - 0.017 14.8 0.9 0.035 13.9 0.1 2.0 2 0 0 2 2 2 0 COX Aromatic Rich Motif Myotub-related PF06602.12 001045070.1_16124001_1 - 9.4e-133 442.2 0.0 1.2e-132 441.9 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain UPF0449 PF15136.4 001045070.1_16124001_1 - 0.0091 16.3 3.0 0.016 15.6 0.8 2.4 3 0 0 3 3 3 1 Uncharacterised protein family UPF0449 Hydrolase_6 PF13344.4 001045070.1_16124001_1 - 0.012 15.6 0.0 0.028 14.4 0.0 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase GRAM PF02893.18 001045070.1_16124001_1 - 0.067 12.9 0.0 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 GRAM domain TPR_14 PF13428.4 001044783.1_16126001_3 - 3.8e-18 64.5 18.5 0.014 16.0 0.3 12.4 9 5 5 14 14 11 4 Tetratricopeptide repeat TPR_19 PF14559.4 001044783.1_16126001_3 - 1e-10 41.8 4.7 0.34 11.3 0.0 8.5 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_2 PF07719.15 001044783.1_16126001_3 - 2.9e-10 39.3 18.3 0.002 17.9 0.1 8.6 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_15 PF13429.4 001044783.1_16126001_3 - 7.9e-09 35.0 7.4 0.018 14.2 0.1 4.7 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.4 001044783.1_16126001_3 - 2.5e-08 34.0 16.5 4.8e-05 23.4 0.0 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.4 001044783.1_16126001_3 - 1.1e-07 31.4 20.3 0.048 13.8 0.1 9.0 10 0 0 10 10 9 2 Tetratricopeptide repeat Suf PF05843.12 001044783.1_16126001_3 - 1.1e-06 28.7 14.5 0.82 9.4 1.2 6.3 5 1 1 6 6 6 2 Suppressor of forked protein (Suf) NRDE-2 PF08424.8 001044783.1_16126001_3 - 1.3e-06 27.6 9.6 6.8e-05 22.0 0.1 5.2 3 2 1 5 5 5 1 NRDE-2, necessary for RNA interference TPR_16 PF13432.4 001044783.1_16126001_3 - 2.1e-05 24.9 17.7 0.16 12.6 0.1 6.0 5 2 1 6 6 5 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.10 001044783.1_16126001_3 - 8.5e-05 22.4 16.5 2.7 7.9 1.3 6.6 6 1 1 7 7 7 2 Mad3/BUB1 homology region 1 TPR_7 PF13176.4 001044783.1_16126001_3 - 0.0024 17.7 7.7 0.12 12.3 0.0 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat PPR PF01535.18 001044783.1_16126001_3 - 0.052 13.7 1.6 0.68 10.2 0.1 3.7 5 0 0 5 5 2 0 PPR repeat ANAPC3 PF12895.5 001044783.1_16126001_3 - 0.071 13.2 0.5 1.9 8.6 0.1 3.4 3 1 1 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.4 001044783.1_16126001_3 - 0.077 13.3 9.7 55 4.4 0.1 7.8 10 0 0 10 10 7 0 Tetratricopeptide repeat TPR_6 PF13174.4 001044783.1_16126001_3 - 0.095 13.2 8.8 3e+02 2.2 0.0 7.7 7 1 0 7 7 6 0 Tetratricopeptide repeat SNAP PF14938.4 001044783.1_16126001_3 - 0.14 11.4 17.9 0.8 8.9 0.0 5.1 3 1 2 7 7 7 0 Soluble NSF attachment protein, SNAP DUF4515 PF14988.4 001044783.1_16126001_3 - 0.16 11.7 1.5 0.52 10.0 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4515) TPR_1 PF00515.26 001044783.1_16126001_3 - 0.2 11.4 16.8 0.44 10.3 0.1 7.0 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_21 PF09976.7 001044783.1_16126001_3 - 0.28 10.8 5.7 49 3.5 0.0 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat-like domain Usp PF00582.24 001044783.1_16126001_3 - 7.8 6.9 8.7 31 4.9 0.8 3.3 3 0 0 3 3 3 0 Universal stress protein family Crystall PF00030.17 001123311.1_16122001_1 - 8.7e-58 192.4 11.8 1.2e-29 102.2 1.6 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 001123311.1_16122001_1 - 1.8e-06 27.7 2.3 0.0064 16.3 0.1 2.6 2 1 0 2 2 2 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 001123311.1_16122001_1 - 0.016 15.2 5.9 0.045 13.8 0.8 2.5 2 1 0 2 2 2 0 Beta/Gamma crystallin LRR_8 PF13855.4 001328384.1_16127001_1 - 1.1e-39 133.8 25.6 1.9e-14 53.0 4.4 4.8 2 2 2 4 4 4 4 Leucine rich repeat 7tm_1 PF00001.19 001328384.1_16127001_1 - 2.6e-18 66.1 11.8 2.6e-18 66.1 11.8 2.0 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) LRR_5 PF13306.4 001328384.1_16127001_1 - 7.2e-18 64.6 1.6 1.1e-07 31.7 0.7 2.6 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001328384.1_16127001_1 - 4.4e-11 42.7 26.3 0.004 17.4 2.5 6.1 3 2 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001328384.1_16127001_1 - 3.4e-09 36.3 9.2 0.00042 19.7 0.1 3.3 1 1 2 3 3 3 3 Leucine-rich repeat Ldl_recept_a PF00057.16 001328384.1_16127001_1 - 7.1e-08 32.4 4.4 7.1e-08 32.4 4.4 2.5 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A LRR_1 PF00560.31 001328384.1_16127001_1 - 0.5 10.9 24.5 0.66 10.5 0.4 7.4 7 1 0 7 7 7 0 Leucine Rich Repeat zf-C2H2_4 PF13894.4 001105105.1_16126001_3 - 4.7e-08 33.1 19.5 0.0012 19.4 3.2 4.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.24 001105105.1_16126001_3 - 2.5e-06 27.5 21.3 0.0023 18.1 4.6 4.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type CpXC PF14353.4 001105105.1_16126001_3 - 7.5e-05 22.6 2.2 0.49 10.3 0.0 3.2 2 1 0 2 2 2 2 CpXC protein zf-H2C2_2 PF13465.4 001105105.1_16126001_3 - 0.0013 19.0 1.1 0.0013 19.0 1.1 4.0 4 0 0 4 4 3 1 Zinc-finger double domain SET PF00856.26 001105105.1_16126001_3 - 0.005 17.1 1.4 0.022 15.0 0.0 2.5 3 1 1 4 4 4 1 SET domain zf-C2H2_2 PF12756.5 001105105.1_16126001_3 - 0.045 14.0 10.3 6.9 6.9 9.3 2.8 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) PDCD2_C PF04194.11 001105105.1_16126001_3 - 0.11 12.5 0.0 0.11 12.5 0.0 2.3 2 1 0 2 2 1 0 Programmed cell death protein 2, C-terminal putative domain zf-C2H2_6 PF13912.4 001105105.1_16126001_3 - 0.2 11.5 16.0 0.063 13.1 2.4 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001105105.1_16126001_3 - 1.8 8.8 9.9 1.7 9.0 1.3 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_9 PF16293.3 001105105.1_16126001_3 - 5.2 6.9 12.9 0.38 10.5 0.6 3.9 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-BED PF02892.13 001105105.1_16126001_3 - 6.5 6.8 8.8 5.9 6.9 0.9 2.6 2 0 0 2 2 2 0 BED zinc finger NACHT PF05729.10 001128355.1_16125001_1 - 4.4e-32 111.1 0.2 1e-31 109.9 0.1 1.7 2 0 0 2 2 2 1 NACHT domain FISNA PF14484.4 001128355.1_16125001_1 - 1.9e-28 98.3 0.8 1.9e-28 98.3 0.8 2.5 2 0 0 2 2 2 1 Fish-specific NACHT associated domain Exonuc_VII_L PF02601.13 001128355.1_16125001_1 - 0.014 14.8 2.5 0.016 14.7 0.3 1.9 2 0 0 2 2 2 0 Exonuclease VII, large subunit IL28A PF15177.4 001128355.1_16125001_1 - 0.037 13.7 1.4 0.062 13.0 0.1 2.0 2 0 0 2 2 2 0 Interleukin-28A Popeye PF04831.11 001128355.1_16125001_1 - 0.088 12.8 0.5 0.28 11.2 0.1 2.0 2 0 0 2 2 2 0 Popeye protein conserved region RHSP PF07999.9 001128355.1_16125001_1 - 0.11 11.1 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 Retrotransposon hot spot protein AAA_16 PF13191.4 001128355.1_16125001_1 - 0.12 12.7 0.1 0.99 9.6 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain 7tm_1 PF00001.19 001082891.1_16123001_1 - 7.6e-42 143.3 22.4 2.3e-41 141.7 22.4 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Peptidase_C13 PF01650.16 001328007.1_16123001_3 - 2.4e-85 286.0 0.7 3e-85 285.7 0.7 1.0 1 0 0 1 1 1 1 Peptidase C13 family CLASP_N PF12348.6 001115139.1_16129001_1 - 6.1e-59 199.2 12.9 9.5e-41 139.7 0.5 4.8 5 0 0 5 5 5 4 CLASP N terminal HEAT PF02985.20 001115139.1_16129001_1 - 5.7e-16 57.1 9.5 3.4e-05 23.6 0.0 9.4 11 0 0 11 11 9 3 HEAT repeat HEAT_EZ PF13513.4 001115139.1_16129001_1 - 6.4e-09 36.0 4.4 0.1 12.9 0.0 5.6 5 0 0 5 5 5 2 HEAT-like repeat Adaptin_N PF01602.18 001115139.1_16129001_1 - 1.1e-08 34.0 2.4 1.9 6.8 0.0 6.0 5 2 0 6 6 6 4 Adaptin N terminal region HEAT_2 PF13646.4 001115139.1_16129001_1 - 1.5e-08 34.7 2.2 0.2 11.9 0.2 7.2 4 3 5 9 9 9 3 HEAT repeats Cnd1 PF12717.5 001115139.1_16129001_1 - 2.6e-07 30.7 8.4 0.00098 19.0 0.7 6.0 7 1 1 8 8 8 2 non-SMC mitotic condensation complex subunit 1 Sec7_N PF12783.5 001115139.1_16129001_1 - 6.6e-06 26.0 6.6 1.3 8.8 0.0 5.6 5 0 0 5 5 5 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Vac14_Fab1_bd PF12755.5 001115139.1_16129001_1 - 6.9e-06 26.4 0.7 0.73 10.3 0.0 5.5 5 1 0 6 6 6 1 Vacuolar 14 Fab1-binding region Tti2 PF10521.7 001115139.1_16129001_1 - 0.00023 20.7 1.7 5.9 6.2 0.0 4.7 4 0 0 4 4 4 1 Tti2 family ParcG PF10274.7 001115139.1_16129001_1 - 0.0012 18.9 0.4 0.021 14.8 0.1 2.7 2 0 0 2 2 2 1 Parkin co-regulated protein MMS19_N PF14500.4 001115139.1_16129001_1 - 0.0014 18.1 5.5 1 8.7 0.1 4.3 3 1 1 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II RTP1_C1 PF10363.7 001115139.1_16129001_1 - 0.0034 17.4 3.3 2.2 8.3 0.5 4.2 3 1 1 4 4 3 1 Required for nuclear transport of RNA pol II C-terminus 1 TFCD_C PF12612.6 001115139.1_16129001_1 - 0.0088 15.8 0.6 0.12 12.1 0.1 3.2 3 0 0 3 3 3 1 Tubulin folding cofactor D C terminal MMS19_C PF12460.6 001115139.1_16129001_1 - 0.024 13.6 2.5 3.2 6.6 0.3 3.1 3 0 0 3 3 3 0 RNAPII transcription regulator C-terminal Dopey_N PF04118.12 001115139.1_16129001_1 - 0.027 13.5 0.6 2 7.4 0.1 2.9 3 0 0 3 3 3 0 Dopey, N-terminal TAN PF11640.6 001115139.1_16129001_1 - 0.067 13.2 4.2 0.53 10.3 0.1 3.8 3 0 0 3 3 3 0 Telomere-length maintenance and DNA damage repair Ipi1_N PF12333.6 001115139.1_16129001_1 - 0.1 13.1 4.1 1.2 9.7 0.1 4.3 4 0 0 4 4 4 0 Rix1 complex component involved in 60S ribosome maturation RasGEF_N_2 PF14663.4 001115139.1_16129001_1 - 0.14 12.4 0.3 5.9 7.1 0.1 3.4 3 0 0 3 3 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Hemerythrin PF01814.21 001115139.1_16129001_1 - 0.38 11.3 5.3 0.33 11.4 0.2 3.2 2 1 1 3 3 3 0 Hemerythrin HHE cation binding domain TPR_20 PF14561.4 001115139.1_16129001_1 - 0.45 10.8 2.1 2.6 8.3 0.2 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat MaoC_dehydratas PF01575.17 144413.1_16123120_3 - 3.7e-20 71.6 0.0 5.9e-20 70.9 0.0 1.2 1 0 0 1 1 1 1 MaoC like domain RNase_P_Rpp14 PF01900.17 144413.1_16123120_3 - 1.4e-09 38.0 0.0 3e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Rpp14/Pop5 family MaoC_dehydrat_N PF13452.4 144413.1_16123120_3 - 3.1e-06 27.2 0.0 5.6e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase 4HBT PF03061.20 144413.1_16123120_3 - 0.01 16.0 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 0 Thioesterase superfamily DUF3585 PF12130.6 137174.1_16128120_1 - 4e-40 136.9 15.6 5.6e-40 136.5 15.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3585) CH PF00307.29 137174.1_16128120_2 - 2e-21 76.0 0.0 3.4e-21 75.3 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 137174.1_16128120_2 - 2.5e-09 36.7 0.1 4.3e-09 35.9 0.1 1.4 1 0 0 1 1 1 1 CAMSAP CH domain LIM PF00412.20 137174.1_16128120_2 - 3.8e-05 23.7 4.7 8.1e-05 22.6 4.7 1.5 1 0 0 1 1 1 1 LIM domain SHIPPO-rpt PF07004.10 137198.1_16122120_1 - 0.13 13.1 8.6 0.96 10.4 0.1 2.9 3 0 0 3 3 3 0 Sperm-tail PG-rich repeat Carb_anhydrase PF00194.19 137291.1_16123120_1 - 1e-75 254.5 0.2 1.2e-75 254.2 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase DUF2254 PF10011.7 137291.1_16123120_3 - 0.19 10.4 0.0 0.24 10.1 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) Nuc_sug_transp PF04142.13 045688.1_16127120_2 - 1.1e-37 129.8 17.3 1.1e-37 129.8 17.3 1.4 2 0 0 2 2 2 1 Nucleotide-sugar transporter DUF4535 PF15054.4 045688.1_16127120_2 - 5.2e-07 29.1 0.0 1.1e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4535) zf-A20 PF01754.14 137317.1_16124120_1 - 9.7e-12 44.5 9.2 2.8e-11 43.0 9.2 1.9 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.14 137317.1_16124120_3 - 1.8e-09 37.5 7.8 4.5e-09 36.2 7.8 1.7 1 0 0 1 1 1 1 AN1-like Zinc finger E2_bind PF08825.8 137317.1_16124120_3 - 0.036 14.1 1.2 5.5 7.1 0.2 2.2 2 0 0 2 2 2 0 E2 binding domain CP2 PF04516.13 135219.1_16124120_2 - 7.6e-59 198.7 0.0 1.1e-58 198.2 0.0 1.1 1 0 0 1 1 1 1 CP2 transcription factor UCR_14kD PF02271.14 135219.1_16124120_3 - 0.26 11.2 0.4 0.65 9.9 0.4 1.6 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex 14kD subunit Troponin PF00992.18 130146.1_16124120_3 - 1.7e-36 125.3 9.6 1.7e-36 125.3 9.6 1.5 2 0 0 2 2 2 1 Troponin Transposase_22 PF02994.12 130146.1_16124120_3 - 0.01 14.6 2.9 0.015 14.0 2.9 1.3 1 0 0 1 1 1 0 L1 transposable element Ten1_2 PF15490.4 136942.1_16122120_1 - 3.4e-20 71.8 0.0 4.6e-20 71.4 0.0 1.1 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit Ten1_2 PF15490.4 136942.1_16122120_2 - 0.1 12.2 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Telomere-capping, CST complex subunit DUF3585 PF12130.6 132439.1_16128120_3 - 5.9e-42 142.9 22.5 5.9e-42 142.9 22.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3585) CH PF00307.29 132439.1_16128120_3 - 2.3e-25 88.8 0.1 5.8e-25 87.5 0.0 1.8 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 132439.1_16128120_3 - 2.9e-08 33.3 0.0 5.7e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain LIM PF00412.20 132439.1_16128120_3 - 2e-06 27.8 5.8 2e-06 27.8 5.8 2.3 2 0 0 2 2 2 1 LIM domain CH_2 PF06294.9 132439.1_16128120_3 - 0.016 15.2 0.0 0.045 13.8 0.0 1.7 1 0 0 1 1 1 0 CH-like domain in sperm protein PRY PF13765.4 137203.1_16124120_1 - 1e-18 66.6 0.4 7.6e-18 63.7 0.3 2.4 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.26 137203.1_16124120_1 - 1.7e-08 34.5 0.5 3.9e-08 33.3 0.5 1.6 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 137203.1_16124120_1 - 4.5e-06 26.6 13.6 4.5e-06 26.6 13.6 2.9 2 0 0 2 2 2 1 B-box zinc finger Tweety PF04906.11 137203.1_16124120_1 - 0.0031 16.1 3.4 0.0037 15.8 1.9 1.9 1 1 1 2 2 2 1 Tweety DUF4407 PF14362.4 137203.1_16124120_1 - 0.0056 15.9 3.3 0.0078 15.5 3.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Apolipoprotein PF01442.16 137203.1_16124120_1 - 0.07 12.9 14.8 0.32 10.7 12.7 2.2 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain DivIC PF04977.13 137203.1_16124120_1 - 0.097 12.3 4.4 3 7.6 0.6 2.8 3 0 0 3 3 3 0 Septum formation initiator OmpH PF03938.12 137203.1_16124120_1 - 0.36 10.7 11.8 2.7 7.8 11.8 2.1 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF342 PF03961.11 137203.1_16124120_1 - 0.42 9.0 8.9 3.8 5.9 2.6 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF342) ABC_tran_CTD PF16326.3 137203.1_16124120_1 - 0.59 10.3 11.6 3.5 7.8 0.6 2.6 2 0 0 2 2 2 0 ABC transporter C-terminal domain Phage_GP20 PF06810.9 137203.1_16124120_1 - 0.79 9.4 6.2 1.2 8.7 1.4 2.3 1 1 1 2 2 2 0 Phage minor structural protein GP20 MbeD_MobD PF04899.10 137203.1_16124120_1 - 1.3 9.1 7.4 6.1 6.9 7.4 2.2 1 1 0 1 1 1 0 MbeD/MobD like PspA_IM30 PF04012.10 137203.1_16124120_1 - 3.1 7.2 13.0 4.9 6.5 10.9 2.3 2 1 0 2 2 2 0 PspA/IM30 family ApoLp-III PF07464.9 137203.1_16124120_1 - 3.8 7.5 11.5 2 8.4 4.4 3.2 3 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Exonuc_VII_L PF02601.13 137203.1_16124120_1 - 4.5 6.6 15.5 22 4.4 15.5 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit MscS_porin PF12795.5 137203.1_16124120_1 - 7.1 6.0 17.0 1.4 8.2 3.8 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain DUF1043 PF06295.10 137203.1_16124120_1 - 8.5 6.3 11.4 0.28 11.0 3.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1043) H-kinase_dim PF02895.12 137203.1_16124120_1 - 9 6.6 7.1 26 5.1 0.2 3.0 3 0 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain zf-C3HC4_4 PF15227.4 137203.1_16124120_3 - 2.9e-13 49.6 12.8 2.9e-13 49.6 12.8 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 137203.1_16124120_3 - 1.2e-08 34.7 11.3 1.2e-08 34.7 11.3 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 137203.1_16124120_3 - 1.2e-08 34.5 11.2 1.2e-08 34.5 11.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 137203.1_16124120_3 - 6.7e-08 32.1 11.3 6.7e-08 32.1 11.3 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 137203.1_16124120_3 - 2.3e-07 30.5 8.5 2.3e-07 30.5 8.5 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 137203.1_16124120_3 - 0.00015 21.5 9.7 0.00015 21.5 9.7 2.8 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_6 PF14835.4 137203.1_16124120_3 - 0.00042 20.0 7.2 0.0005 19.7 4.9 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein U-box PF04564.13 137203.1_16124120_3 - 0.0012 18.8 0.0 0.0019 18.2 0.0 1.3 1 0 0 1 1 1 1 U-box domain Prok-RING_4 PF14447.4 137203.1_16124120_3 - 0.0016 18.1 8.7 0.0016 18.1 8.7 2.7 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 137203.1_16124120_3 - 0.0018 18.2 12.1 0.01 15.8 6.4 2.5 2 0 0 2 2 2 1 zinc RING finger of MSL2 Ribosomal_S27 PF01599.17 137290.1_16121120_3 - 0.22 11.6 6.5 0.42 10.7 6.5 1.4 1 0 0 1 1 1 0 Ribosomal protein S27a Bromodomain PF00439.23 147500.1_16129120_3 - 2.3e-06 27.5 0.0 6.1e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 Bromodomain zf-C3HC4_4 PF15227.4 037706.1_16125120_3 - 1.1e-13 50.9 11.9 1.1e-13 50.9 11.9 3.2 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 037706.1_16125120_3 - 5.2e-11 42.2 9.0 5.2e-11 42.2 9.0 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 037706.1_16125120_3 - 3.9e-09 36.1 9.6 3.9e-09 36.1 9.6 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 037706.1_16125120_3 - 8.8e-09 34.9 10.1 8.8e-09 34.9 10.1 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 037706.1_16125120_3 - 2.7e-07 30.2 7.3 2.7e-07 30.2 7.3 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 037706.1_16125120_3 - 8.1e-07 29.1 10.3 8.1e-07 29.1 10.3 3.5 3 0 0 3 3 3 1 Ring finger domain zf-B_box PF00643.22 037706.1_16125120_3 - 3.1e-06 27.1 9.3 3.1e-06 27.1 9.3 3.9 4 0 0 4 4 4 1 B-box zinc finger zf-RING_5 PF14634.4 037706.1_16125120_3 - 9.6e-05 22.1 9.2 9.6e-05 22.1 9.2 3.2 2 1 0 2 2 1 1 zinc-RING finger domain U-box PF04564.13 037706.1_16125120_3 - 0.0003 20.8 0.0 0.00059 19.8 0.0 1.4 1 0 0 1 1 1 1 U-box domain Prok-RING_4 PF14447.4 037706.1_16125120_3 - 0.0053 16.5 8.5 0.0053 16.5 8.5 3.2 3 1 0 3 3 2 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.4 037706.1_16125120_3 - 0.017 14.8 4.1 0.05 13.3 4.1 1.8 1 0 0 1 1 1 0 zf-RING of BARD1-type protein EF-hand_6 PF13405.4 137289.1_16122120_3 - 0.0087 15.8 0.0 0.047 13.5 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.4 137289.1_16122120_3 - 0.13 11.7 0.5 0.26 10.8 0.0 1.7 2 0 0 2 2 2 0 EF hand TPD52 PF04201.13 204215.1_23523001_1 - 9.2e-74 246.3 10.6 1.2e-73 245.9 10.6 1.1 1 0 0 1 1 1 1 Tumour protein D52 family NUDE_C PF04880.11 204215.1_23523001_1 - 0.00016 22.1 3.4 0.00029 21.2 3.4 1.5 1 0 0 1 1 1 1 NUDE protein, C-terminal conserved region WEMBL PF05701.9 204215.1_23523001_1 - 0.0016 17.1 2.7 0.0018 16.8 2.7 1.2 1 0 0 1 1 1 1 Weak chloroplast movement under blue light OmpH PF03938.12 204215.1_23523001_1 - 0.006 16.5 2.0 0.051 13.4 2.5 1.9 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) DUF3458 PF11940.6 204215.1_23523001_1 - 0.0088 15.0 2.9 0.011 14.6 2.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Cnn_1N PF07989.9 204215.1_23523001_1 - 0.026 14.5 2.9 0.071 13.1 2.9 1.8 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 IncA PF04156.12 204215.1_23523001_1 - 0.028 14.1 3.2 0.047 13.4 3.2 1.3 1 0 0 1 1 1 0 IncA protein Uds1 PF15456.4 204215.1_23523001_1 - 0.029 14.4 5.3 0.07 13.2 5.3 1.6 1 0 0 1 1 1 0 Up-regulated During Septation Prefoldin_3 PF13758.4 204215.1_23523001_1 - 0.057 13.3 0.4 0.13 12.2 0.3 1.6 1 1 0 1 1 1 0 Prefoldin subunit TBPIP PF07106.11 204215.1_23523001_1 - 0.063 12.9 3.4 0.1 12.2 3.4 1.3 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Vfa1 PF08432.8 204215.1_23523001_1 - 0.39 10.9 3.2 0.55 10.4 3.2 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1192 PF06698.9 204215.1_23523001_1 - 0.65 10.0 4.1 1.4 8.9 4.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) 7tm_1 PF00001.19 001002443.2_16124001_3 - 5.8e-40 137.1 8.4 9.6e-40 136.4 8.4 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001002443.2_16124001_3 - 1.1e-05 24.8 6.5 6.9e-05 22.2 6.8 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv Cytochrom_B_N_2 PF13631.4 001002443.2_16124001_3 - 1.9e-05 24.6 0.5 0.00013 21.9 0.1 2.2 2 0 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB 7TM_GPCR_Srt PF10321.7 001002443.2_16124001_3 - 0.00025 20.0 16.4 0.041 12.7 4.7 2.3 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srt 7TM_GPCR_Srsx PF10320.7 001002443.2_16124001_3 - 0.014 14.6 8.5 0.36 10.0 2.7 2.4 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srsx DUF898 PF05987.11 001002443.2_16124001_3 - 0.41 9.5 7.7 0.042 12.8 2.6 1.9 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF898) DUF4190 PF13828.4 001002443.2_16124001_3 - 4 7.1 11.1 1.8 8.2 0.8 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4190) Sulfatase PF00884.21 001080068.1_16124001_2 - 3.3e-49 167.8 0.0 5.1e-49 167.2 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.20 001080068.1_16124001_2 - 1.1e-07 31.6 0.1 6.7e-05 22.5 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.15 001080068.1_16124001_2 - 0.00011 20.9 0.0 0.00035 19.2 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF229) Pribosyltran PF00156.25 204848.1_23524001_3 - 1.8e-22 79.4 0.0 2.4e-22 79.0 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.4 204848.1_23524001_3 - 0.099 11.9 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase TPD PF14811.4 001031200.1_23528001_2 - 1e-41 141.9 0.1 5.9e-41 139.4 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function TPD sequence-motif PRP9_N PF16958.3 001031200.1_23528001_2 - 0.12 12.3 1.2 0.21 11.5 1.2 1.3 1 0 0 1 1 1 0 Pre-mRNA-splicing factor PRP9 N-terminus Dickkopf_N PF04706.10 205125.1_23523001_3 - 5.2e-16 58.7 19.9 5.2e-16 58.7 19.9 3.1 3 0 0 3 3 3 2 Dickkopf N-terminal cysteine-rich region p450 PF00067.20 001089458.1_16125001_3 - 5e-102 341.9 0.0 5.9e-102 341.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Zip PF02535.20 001007933.1_23529001_3 - 7.8e-37 127.1 20.5 1.8e-27 96.3 11.7 2.2 1 1 1 2 2 2 2 ZIP Zinc transporter zf-C3HC4_3 PF13920.4 001007925.1_23527001_1 - 2.6e-09 36.7 10.6 2.6e-09 36.7 10.6 4.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001007925.1_23527001_1 - 2.1e-08 34.2 14.3 2.1e-08 34.2 14.3 3.4 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.4 001007925.1_23527001_1 - 3.7e-08 33.0 13.5 1.4e-07 31.1 13.5 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001007925.1_23527001_1 - 8.3e-06 25.4 10.5 8.3e-06 25.4 10.5 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.4 001007925.1_23527001_1 - 2.2e-05 24.2 10.1 7.2e-05 22.6 10.1 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001007925.1_23527001_1 - 2.3e-05 24.0 12.6 2.3e-05 24.0 12.6 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001007925.1_23527001_1 - 0.00061 19.9 8.9 0.00061 19.9 8.9 2.6 3 0 0 3 3 3 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.4 001007925.1_23527001_1 - 0.098 12.7 11.5 0.56 10.3 11.5 2.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING PPP4R2 PF09184.9 001006142.1_23526001_1 - 1.9e-78 263.9 2.2 1.9e-78 263.9 2.2 2.3 1 1 1 2 2 2 1 PPP4R2 zf-C3HC4_3 PF13920.4 001007848.1_23525001_2 - 4e-05 23.3 7.8 9.4e-05 22.1 7.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001007848.1_23525001_2 - 0.00086 19.0 7.7 0.0021 17.8 7.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001007848.1_23525001_2 - 0.002 17.8 9.3 0.0081 15.8 9.3 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001007848.1_23525001_2 - 0.0024 17.6 7.6 0.0066 16.3 7.6 1.8 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.4 001007848.1_23525001_2 - 0.027 14.2 6.5 0.064 13.0 6.5 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DZR PF12773.5 001007848.1_23525001_2 - 0.038 13.9 6.3 0.21 11.5 6.3 2.2 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_UBOX PF13445.4 001007848.1_23525001_2 - 0.046 13.6 4.8 0.16 11.9 4.8 2.0 1 0 0 1 1 1 0 RING-type zinc-finger C1_4 PF07975.10 001007848.1_23525001_2 - 0.055 13.6 2.5 0.18 11.9 2.5 1.9 1 0 0 1 1 1 0 TFIIH C1-like domain zinc-ribbons_6 PF07191.10 001007848.1_23525001_2 - 0.085 12.7 10.3 0.17 11.8 10.3 1.5 1 0 0 1 1 1 0 zinc-ribbons zf-RING_4 PF14570.4 001007848.1_23525001_2 - 2.7 7.7 8.9 0.21 11.2 3.7 1.8 2 0 0 2 2 1 0 RING/Ubox like zinc-binding domain zf-RING_2 PF13639.4 001007848.1_23525001_2 - 2.8 8.1 13.7 0.23 11.6 8.4 2.0 2 0 0 2 2 2 0 Ring finger domain 7tm_1 PF00001.19 001031216.1_23523001_1 - 1.2e-23 83.5 3.5 1.2e-23 83.5 3.5 2.0 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001031216.1_23523001_1 - 0.095 11.9 10.6 0.087 12.0 4.0 2.4 1 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx PrmA PF06325.11 001005831.1_23525001_1 - 7e-09 35.3 0.3 1.9e-05 24.1 0.2 2.3 2 0 0 2 2 2 2 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.4 001005831.1_23525001_1 - 5e-05 23.8 0.0 0.0024 18.4 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.5 001005831.1_23525001_1 - 0.00084 19.2 0.0 0.0026 17.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.13 001005831.1_23525001_1 - 0.0088 15.6 0.0 0.05 13.1 0.0 2.0 2 0 0 2 2 2 1 Conserved hypothetical protein 95 Methyltransf_4 PF02390.15 001005831.1_23525001_1 - 0.047 13.0 0.1 0.1 11.9 0.1 1.6 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_23 PF13489.4 001005831.1_23525001_1 - 0.07 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.12 001005831.1_23525001_1 - 0.091 12.2 0.1 0.36 10.2 0.1 1.8 2 0 0 2 2 2 0 Methyltransferase small domain LIM PF00412.20 205248.1_23523001_1 - 7.3e-29 99.7 24.6 2.1e-16 59.8 5.1 2.3 2 0 0 2 2 2 2 LIM domain Gastrin PF00918.15 001001741.1_23522001_3 - 4.7e-50 169.6 0.0 6.1e-50 169.3 0.0 1.1 1 0 0 1 1 1 1 Gastrin/cholecystokinin family HCO3_cotransp PF00955.19 001290554.1_23527001_2 - 7e-191 635.4 15.6 1.5e-111 373.7 6.6 2.1 1 1 1 2 2 2 2 HCO3- transporter family Band_3_cyto PF07565.11 001290554.1_23527001_2 - 3.9e-78 262.8 0.0 6.2e-78 262.1 0.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Anoctamin PF04547.10 001290554.1_23527001_2 - 0.016 13.9 0.5 0.04 12.6 0.5 1.6 1 0 0 1 1 1 0 Calcium-activated chloride channel MORN PF02493.18 001024413.2_16124001_3 - 6.7e-13 47.6 13.3 6.3e-07 28.8 0.3 4.1 4 1 0 4 4 4 3 MORN repeat zf-HC5HC2H_2 PF13832.4 201652.2_16127001_1 - 1.6e-29 102.1 7.3 1.6e-29 102.1 7.3 2.5 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 201652.2_16127001_1 - 9.6e-25 86.5 5.6 9.6e-25 86.5 5.6 3.2 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.4 201652.2_16127001_1 - 2.7e-12 45.8 7.4 2.7e-12 45.8 7.4 3.8 4 0 0 4 4 4 1 PHD-finger PHD PF00628.27 201652.2_16127001_1 - 8.9e-11 41.4 9.6 8.9e-11 41.4 9.6 3.2 3 0 0 3 3 3 2 PHD-finger EPL1 PF10513.7 201652.2_16127001_1 - 1.1e-07 32.3 1.7 1.2e-07 32.2 0.1 1.9 2 0 0 2 2 2 1 Enhancer of polycomb-like TMEM141 PF15110.4 001305669.2_23522001_2 - 8.1e-40 135.2 0.2 1.1e-39 134.7 0.2 1.2 1 0 0 1 1 1 1 TMEM141 protein family TMEM141 PF15110.4 131211.2_23522120_1 - 1.4e-20 73.5 0.1 2.1e-20 72.9 0.1 1.2 1 0 0 1 1 1 1 TMEM141 protein family TMEM141 PF15110.4 131211.2_23522120_2 - 9.5e-14 51.6 0.1 1.6e-13 50.9 0.1 1.3 1 0 0 1 1 1 1 TMEM141 protein family SelR PF01641.16 001346746.2_23522001_2 - 5.9e-18 64.9 0.5 8.5e-18 64.4 0.5 1.3 1 0 0 1 1 1 1 SelR domain Zn_ribbon_recom PF13408.4 001346746.2_23522001_2 - 0.084 13.3 0.5 16 5.9 0.0 2.3 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain TF_Zn_Ribbon PF08271.10 001346746.2_23522001_2 - 0.19 11.1 1.0 5.5 6.5 0.2 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding zinc_ribbon_2 PF13240.4 001346746.2_23522001_2 - 0.26 10.9 2.8 5.3 6.8 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain EF-hand_7 PF13499.4 001114972.2_23529001_1 - 0.024 15.0 0.0 0.053 13.9 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001114972.2_23529001_1 - 0.048 13.8 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region RRM_1 PF00076.20 199925.1_16123001_3 - 6.1e-17 61.1 0.1 9.6e-17 60.5 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 199925.1_16123001_3 - 5.8e-06 25.8 0.0 1.3e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Selenoprotein_S PF06936.9 001024734.3_23523001_3 - 6.1e-85 283.8 1.9 7.5e-85 283.5 1.9 1.1 1 0 0 1 1 1 1 Selenoprotein S (SelS) DUF788 PF05620.9 001024734.3_23523001_3 - 0.026 14.3 0.1 0.059 13.2 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF788) DUF1517 PF07466.9 001024734.3_23523001_3 - 0.097 11.7 0.6 0.13 11.3 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1517) Peptidase_S8 PF00082.20 199213.2_16129001_3 - 5.1e-39 134.2 0.0 7.3e-39 133.7 0.0 1.2 1 0 0 1 1 1 1 Subtilase family ABC_transp_aux PF09822.7 199213.2_16129001_3 - 0.04 13.3 0.0 0.063 12.6 0.0 1.2 1 0 0 1 1 1 0 ABC-type uncharacterized transport system MBT PF02820.16 001089484.1_16124001_3 - 4.8e-21 74.8 0.0 9e-21 73.9 0.0 1.4 1 0 0 1 1 1 1 mbt repeat DUF2781 PF10914.6 001080661.1_16123001_1 - 2.8e-17 63.3 20.8 1.6e-14 54.4 3.5 2.7 3 0 0 3 3 3 2 Protein of unknown function (DUF2781) Peptidase_C12 PF01088.19 001024405.1_16122001_1 - 6.8e-66 221.9 0.0 8.4e-66 221.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Rapsyn_N PF10579.7 178305.1_16123001_1 - 3.1e-46 155.2 0.4 1.1e-45 153.5 0.2 2.0 2 0 0 2 2 2 1 Rapsyn N-terminal myristoylation and linker region TPR_12 PF13424.4 178305.1_16123001_1 - 2.1e-18 66.2 0.4 2.2e-07 30.9 0.0 4.9 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.26 178305.1_16123001_1 - 1.7e-17 62.3 9.1 0.0059 16.3 0.1 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.15 178305.1_16123001_1 - 7.8e-15 53.6 3.4 0.14 12.2 0.1 7.4 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.4 178305.1_16123001_1 - 2.6e-10 39.4 0.9 1.1 9.3 0.0 7.1 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_8 PF13181.4 178305.1_16123001_1 - 1.5e-09 37.2 6.8 0.05 13.7 0.0 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat zf-RING_11 PF17123.3 178305.1_16123001_1 - 1e-06 28.2 1.9 1e-06 28.2 1.9 2.8 2 0 0 2 2 1 1 RING-like zinc finger zf-RING_2 PF13639.4 178305.1_16123001_1 - 4e-06 26.8 5.2 4e-06 26.8 5.2 3.2 3 0 0 3 3 3 1 Ring finger domain TPR_10 PF13374.4 178305.1_16123001_1 - 2e-05 24.2 0.2 0.69 9.7 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat zf-RING_5 PF14634.4 178305.1_16123001_1 - 9.3e-05 22.2 6.8 9.3e-05 22.2 6.8 3.6 4 0 0 4 4 3 1 zinc-RING finger domain SNAP PF14938.4 178305.1_16123001_1 - 0.00017 21.0 0.1 0.19 11.0 0.0 2.3 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP DUF3856 PF12968.5 178305.1_16123001_1 - 0.00036 20.5 0.9 0.94 9.4 0.1 3.9 3 1 1 4 4 3 1 Domain of Unknown Function (DUF3856) TPR_11 PF13414.4 178305.1_16123001_1 - 0.0004 19.9 3.8 1.1 8.8 0.1 4.4 4 0 0 4 4 4 1 TPR repeat Prok-RING_4 PF14447.4 178305.1_16123001_1 - 0.00091 18.9 6.2 0.00091 18.9 6.2 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 TPR_19 PF14559.4 178305.1_16123001_1 - 0.0019 18.5 0.5 1.6 9.2 0.0 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.5 178305.1_16123001_1 - 0.0081 16.2 7.4 7.9 6.6 0.1 4.5 4 2 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 zf-C3HC4 PF00097.23 178305.1_16123001_1 - 0.015 15.1 5.0 0.015 15.1 5.0 3.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) ANAPC5 PF12862.5 178305.1_16123001_1 - 0.015 15.2 0.1 30 4.7 0.0 4.0 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 5 TPR_6 PF13174.4 178305.1_16123001_1 - 0.019 15.5 2.8 10 6.9 0.0 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 178305.1_16123001_1 - 0.058 13.3 2.5 11 6.1 0.0 4.2 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat zf-rbx1 PF12678.5 178305.1_16123001_1 - 0.11 12.7 8.3 0.15 12.2 6.3 2.5 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 178305.1_16123001_1 - 0.15 12.0 12.0 0.24 11.3 7.0 3.0 2 0 0 2 2 2 0 RING-type zinc-finger AKNA PF12443.6 178305.1_16123001_1 - 0.17 12.4 0.3 0.17 12.4 0.3 1.8 2 0 0 2 2 1 0 AT-hook-containing transcription factor zf-C3H2C3 PF17122.3 178305.1_16123001_1 - 0.22 11.5 5.3 0.82 9.6 5.3 2.1 1 0 0 1 1 1 0 Zinc-finger Innexin PF00876.16 001100030.2_16126001_2 - 2.5e-16 59.8 0.6 2.5e-16 59.8 0.6 1.6 2 0 0 2 2 2 1 Innexin Gal_Lectin PF02140.16 001110111.3_16122001_1 - 6.2e-24 84.1 3.7 6.2e-24 84.1 3.7 1.5 2 0 0 2 2 2 1 Galactose binding lectin domain DUF1669 PF07894.10 001007320.3_16126001_2 - 8e-107 356.7 0.0 1.5e-106 355.9 0.0 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1669) PLDc_2 PF13091.4 001007320.3_16126001_2 - 2.3e-09 37.1 0.0 4.2e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 PLD-like domain PP_kinase_C PF13090.4 001007320.3_16126001_2 - 0.085 11.5 0.0 0.16 10.6 0.0 1.3 1 0 0 1 1 1 0 Polyphosphate kinase C-terminal domain PARP PF00644.18 001327797.2_16129001_1 - 9e-38 129.8 0.1 1.6e-37 129.0 0.1 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.18 001327797.2_16129001_1 - 3.8e-16 59.3 2.6 8.7e-15 54.9 2.1 2.6 2 0 0 2 2 2 1 WWE domain Torus PF16131.3 001327797.2_16129001_1 - 0.00013 22.5 0.3 0.00013 22.5 0.3 2.6 3 0 0 3 3 3 1 Torus domain zf-CCCH PF00642.22 001327797.2_16129001_1 - 0.0035 17.1 2.6 0.0035 17.1 2.6 4.3 3 2 1 4 4 4 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TPR_19 PF14559.4 001327797.2_16129001_1 - 0.078 13.4 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Hairy_orange PF07527.11 001005848.2_23523001_3 - 6.5e-19 67.7 0.3 1.1e-18 66.9 0.3 1.4 1 0 0 1 1 1 1 Hairy Orange HLH PF00010.24 001005848.2_23523001_3 - 1.1e-13 50.7 4.8 2.1e-13 49.9 4.5 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DnaJ_C PF01556.16 001017606.1_16123001_1 - 5.1e-38 130.4 0.0 6.8e-38 129.9 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.29 001017606.1_16123001_1 - 6.3e-21 74.1 2.1 1.5e-20 73.0 2.1 1.7 1 0 0 1 1 1 1 DnaJ domain PTH2 PF01981.14 001326568.1_16125001_3 - 1.1e-34 119.0 0.6 1.7e-34 118.4 0.6 1.3 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 UBA PF00627.29 001326568.1_16125001_3 - 0.038 13.8 0.1 0.076 12.8 0.1 1.4 1 0 0 1 1 1 0 UBA/TS-N domain Ins145_P3_rec PF08709.9 001313811.1_16129001_3 - 6e-91 303.3 0.0 6e-90 300.0 0.0 2.4 1 1 1 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RYDR_ITPR PF01365.19 001313811.1_16129001_3 - 3.7e-66 222.4 30.2 3.1e-59 199.7 4.9 4.7 4 0 0 4 4 4 2 RIH domain MIR PF02815.17 001313811.1_16129001_3 - 2.2e-65 219.9 3.4 2.4e-61 206.7 0.0 3.0 3 0 0 3 3 3 2 MIR domain RIH_assoc PF08454.9 001313811.1_16129001_3 - 1.9e-31 107.8 6.3 1.9e-31 107.8 6.3 6.9 5 3 0 5 5 5 2 RyR and IP3R Homology associated Ion_trans PF00520.29 001313811.1_16129001_3 - 1.9e-16 59.9 9.1 4.3e-16 58.7 9.1 1.6 1 0 0 1 1 1 1 Ion transport protein Caldesmon PF02029.13 001320459.1_16125001_2 - 1.2e-114 383.7 92.9 1.2e-114 383.7 92.9 1.9 1 1 1 2 2 2 1 Caldesmon I-set PF07679.14 001331200.1_16125001_1 - 3e-36 123.2 0.0 7.4e-19 67.5 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin I-set domain fn3 PF00041.19 001331200.1_16125001_1 - 8.1e-30 102.9 2.9 1.1e-14 54.4 0.0 3.4 2 1 1 3 3 3 2 Fibronectin type III domain Ig_3 PF13927.4 001331200.1_16125001_1 - 4.4e-24 84.8 0.0 8.6e-13 48.6 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001331200.1_16125001_1 - 8.7e-13 48.3 0.0 2.1e-05 24.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001331200.1_16125001_1 - 1.8e-10 40.7 0.1 2.4e-06 27.5 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 001331200.1_16125001_1 - 1.7e-07 31.2 0.3 0.055 13.5 0.1 3.8 2 2 1 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 001331200.1_16125001_1 - 3.5e-05 23.6 0.0 0.049 13.6 0.0 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.3 001331200.1_16125001_1 - 0.001 19.4 1.2 1.4 9.4 0.4 3.0 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Ig_3 PF13927.4 001278321.1_16125001_1 - 4.8e-17 62.2 0.0 2.2e-05 24.8 0.0 3.9 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.4 001278321.1_16125001_1 - 3.8e-12 46.3 0.0 0.0049 17.1 0.0 4.5 4 1 0 4 4 4 3 Immunoglobulin domain I-set PF07679.14 001278321.1_16125001_1 - 2.8e-08 33.6 0.0 0.0025 17.7 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.15 001278321.1_16125001_1 - 3.7e-08 33.4 0.0 2.4e-07 30.8 0.0 2.4 3 0 0 3 3 3 1 Immunoglobulin V-set domain ig PF00047.23 001278321.1_16125001_1 - 4.3e-08 33.1 0.0 0.25 11.4 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.10 001278321.1_16125001_1 - 4e-06 26.7 0.0 0.073 13.0 0.0 2.8 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain AAA PF00004.27 001004640.3_16123001_1 - 1.4e-35 122.4 0.1 4.1e-35 120.9 0.0 1.9 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 001004640.3_16123001_1 - 1.8e-06 27.8 0.0 7.2e-06 25.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 001004640.3_16123001_1 - 0.00024 21.4 2.0 0.0036 17.6 0.1 2.8 2 1 1 3 3 3 1 AAA ATPase domain AAA_14 PF13173.4 001004640.3_16123001_1 - 0.00046 20.1 0.0 0.0012 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.10 001004640.3_16123001_1 - 0.0012 18.0 0.0 0.0041 16.3 0.0 2.0 2 1 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.12 001004640.3_16123001_1 - 0.0021 18.1 0.0 0.0051 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.4 001004640.3_16123001_1 - 0.011 15.8 0.1 0.029 14.4 0.0 1.8 2 0 0 2 2 1 0 AAA domain Mg_chelatase PF01078.19 001004640.3_16123001_1 - 0.015 14.6 0.2 0.049 12.9 0.1 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TniB PF05621.9 001004640.3_16123001_1 - 0.015 14.4 0.1 5.8 5.9 0.0 3.1 2 1 1 3 3 3 0 Bacterial TniB protein AAA_22 PF13401.4 001004640.3_16123001_1 - 0.017 15.3 4.2 0.37 10.9 0.1 3.5 2 1 2 4 4 4 0 AAA domain AAA_18 PF13238.4 001004640.3_16123001_1 - 0.02 15.3 0.1 0.13 12.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.13 001004640.3_16123001_1 - 0.039 12.7 0.2 0.12 11.1 0.2 1.9 1 1 0 1 1 1 0 Rad17 cell cycle checkpoint protein RNA_helicase PF00910.20 001004640.3_16123001_1 - 0.039 14.2 0.0 0.12 12.6 0.0 1.8 1 1 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.15 001004640.3_16123001_1 - 0.043 13.5 0.0 0.12 12.0 0.0 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.11 001004640.3_16123001_1 - 0.058 12.2 0.0 0.091 11.5 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus AAA_24 PF13479.4 001004640.3_16123001_1 - 0.076 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain SKI PF01202.20 001004640.3_16123001_1 - 0.08 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Shikimate kinase Parvo_NS1 PF01057.15 001004640.3_16123001_1 - 0.1 11.5 0.0 0.23 10.4 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.24 001004640.3_16123001_1 - 0.12 11.9 0.0 0.49 9.9 0.0 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_25 PF13481.4 001004640.3_16123001_1 - 0.14 11.6 0.3 1.2 8.6 0.1 2.2 1 1 0 2 2 2 0 AAA domain TsaE PF02367.15 001004640.3_16123001_1 - 0.14 12.0 0.0 0.34 10.8 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PDZ PF00595.22 200709.1_16125001_2 - 6.4e-20 71.2 0.4 1e-19 70.5 0.4 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) L27 PF02828.14 200709.1_16125001_2 - 2.9e-14 52.4 0.0 5.5e-14 51.5 0.0 1.5 1 0 0 1 1 1 1 L27 domain PDZ_2 PF13180.4 200709.1_16125001_2 - 0.0042 17.2 0.0 0.008 16.3 0.0 1.3 1 0 0 1 1 1 1 PDZ domain zf-3CxxC PF13695.4 001128720.1_16122001_1 - 4.3e-24 84.7 1.0 6e-24 84.3 1.0 1.2 1 0 0 1 1 1 1 Zinc-binding domain YyzF PF14116.4 001128720.1_16122001_1 - 0.0084 16.0 0.1 0.66 9.9 0.0 2.9 3 0 0 3 3 3 1 YyzF-like protein zf-3CxxC_2 PF17180.2 001128720.1_16122001_1 - 2.8 8.6 16.2 0.5 11.0 1.3 3.7 3 1 0 3 3 3 0 Zinc-binding domain FKBP_C PF00254.26 001077770.1_16122001_2 - 1.3e-30 105.4 0.0 2.4e-30 104.6 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase NAD_binding_10 PF13460.4 131681.2_16123001_1 - 3.8e-09 36.6 0.0 5.3e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.22 131681.2_16123001_1 - 0.0026 18.0 0.0 0.0052 17.1 0.0 1.5 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.16 131681.2_16123001_1 - 0.018 15.2 0.0 0.031 14.4 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.18 131681.2_16123001_1 - 0.1 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sgf11 PF08209.9 001005396.1_16123001_2 - 4.4e-18 64.4 2.8 1e-17 63.3 2.8 1.6 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) zf-C2HC_2 PF13913.4 001005396.1_16123001_2 - 0.036 13.8 1.1 0.098 12.5 1.1 1.8 1 0 0 1 1 1 0 zinc-finger of a C2HC-type Carboxyl_trans PF01039.20 001113652.1_16125001_2 - 2.1e-96 323.5 0.0 3.3e-96 322.8 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain KH_1 PF00013.27 212991.3_16125001_2 - 6.2e-43 144.3 10.5 7.7e-20 70.4 1.9 3.3 3 0 0 3 3 3 3 KH domain ROKNT PF08067.9 212991.3_16125001_2 - 9.4e-22 76.9 8.6 1.7e-21 76.0 8.6 1.4 1 0 0 1 1 1 1 ROKNT (NUC014) domain KH_2 PF07650.15 212991.3_16125001_2 - 2e-12 46.6 9.4 0.001 18.7 0.5 3.4 2 1 1 3 3 3 3 KH domain KH_4 PF13083.4 212991.3_16125001_2 - 1.7e-08 34.1 4.1 1e-05 25.2 0.0 3.3 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 212991.3_16125001_2 - 8.3e-05 22.5 3.3 0.43 10.6 0.1 3.5 3 0 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.3 212991.3_16125001_2 - 0.037 13.9 0.0 2 8.3 0.0 2.4 2 0 0 2 2 2 0 KH-like RNA-binding domain DJ-1_PfpI PF01965.22 212991.3_16125001_2 - 0.042 13.5 0.0 0.087 12.5 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family VWC PF00093.16 001013486.1_16123001_3 - 1.2e-14 54.2 48.9 6e-09 36.0 15.4 3.3 3 0 0 3 3 3 3 von Willebrand factor type C domain Pacifastin_I PF05375.11 001013486.1_16123001_3 - 0.017 14.7 2.6 0.017 14.7 2.6 4.3 4 1 0 4 4 4 0 Pacifastin inhibitor (LCMII) zf-H2C2_2 PF13465.4 001309467.1_16126001_1 - 1.9e-44 148.0 74.9 1.7e-08 34.4 2.8 11.3 11 0 0 11 11 11 6 Zinc-finger double domain zf-H2C2_5 PF13909.4 001309467.1_16126001_1 - 7.6e-33 111.8 73.0 6.5e-09 35.3 3.0 8.5 8 0 0 8 8 8 8 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 001309467.1_16126001_1 - 1.2e-19 69.5 90.0 0.0013 18.9 3.3 10.7 10 0 0 10 10 10 8 Zinc finger, C2H2 type GAGA PF09237.9 001309467.1_16126001_1 - 6.5e-06 25.7 17.0 0.032 13.9 0.1 5.0 2 2 3 5 5 5 3 GAGA factor zf-C2H2_4 PF13894.4 001309467.1_16126001_1 - 0.018 15.7 90.4 0.13 13.0 2.4 11.1 11 0 0 11 11 11 0 C2H2-type zinc finger Pkinase_Tyr PF07714.15 001004543.1_16127001_2 - 6.2e-98 327.1 0.0 8e-98 326.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001004543.1_16127001_2 - 1.6e-49 168.5 0.0 2.2e-49 168.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001004543.1_16127001_2 - 8.2e-24 83.3 0.1 1.5e-23 82.5 0.1 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001004543.1_16127001_2 - 1.3e-16 59.8 0.0 4.9e-16 57.9 0.0 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 001004543.1_16127001_2 - 5.7e-08 32.4 0.0 1.1e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001004543.1_16127001_2 - 7.2e-08 31.9 0.0 1.4e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 001004543.1_16127001_2 - 0.0021 18.2 0.1 0.0038 17.3 0.1 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain DUF1241 PF06840.9 212933.1_16123001_3 - 7.4e-62 207.3 2.2 1e-61 206.8 2.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) CENP-L PF13092.4 212933.1_16123001_3 - 0.018 15.1 0.1 0.021 14.9 0.1 1.2 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 Claudin_2 PF13903.4 001128746.1_16123001_1 - 3.8e-20 72.3 0.5 1.8e-19 70.1 0.5 1.9 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.18 001128746.1_16123001_1 - 0.002 17.9 6.4 0.014 15.1 2.9 2.7 3 0 0 3 3 3 1 PMP-22/EMP/MP20/Claudin family GSG-1 PF07803.9 001128746.1_16123001_1 - 0.053 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 GSG1-like protein AP3D1 PF06375.9 001079961.2_16126001_2 - 0.36 11.0 15.6 0.057 13.6 4.2 2.5 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 zf-H2C2_2 PF13465.4 001128691.1_16123001_3 - 2.8e-54 179.1 70.1 4.9e-09 36.1 0.8 10.4 10 0 0 10 10 10 8 Zinc-finger double domain zf-C2H2 PF00096.24 001128691.1_16123001_3 - 4.2e-47 155.9 76.5 2.3e-07 30.7 2.9 9.4 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001128691.1_16123001_3 - 3.9e-37 123.6 70.4 0.00011 22.6 5.3 9.3 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001128691.1_16123001_3 - 1e-22 79.4 59.4 0.00066 19.4 4.5 9.4 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001128691.1_16123001_3 - 3.4e-14 52.6 35.7 0.0038 17.4 1.8 8.4 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 001128691.1_16123001_3 - 7.7e-07 29.0 29.0 0.078 13.0 1.3 6.5 5 1 2 7 7 7 3 Zinc ribbon domain C1_1 PF00130.20 001128691.1_16123001_3 - 1.1e-06 28.3 36.5 0.6 9.9 2.7 7.7 4 2 3 7 7 7 5 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_11 PF16622.3 001128691.1_16123001_3 - 4.5e-06 26.2 52.7 0.041 13.5 2.7 8.6 9 0 0 9 9 9 4 zinc-finger C2H2-type ADK_lid PF05191.12 001128691.1_16123001_3 - 0.00023 21.0 21.6 2.3 8.2 0.1 7.2 3 1 2 5 5 5 1 Adenylate kinase, active site lid zinc_ribbon_15 PF17032.3 001128691.1_16123001_3 - 0.00026 21.6 34.2 0.35 11.5 1.3 5.4 1 1 7 8 8 8 4 zinc-ribbon family zf-met PF12874.5 001128691.1_16123001_3 - 0.00059 20.0 4.4 0.00059 20.0 4.4 8.3 9 0 0 9 9 9 4 Zinc-finger of C2H2 type zf-AN1 PF01428.14 001128691.1_16123001_3 - 0.0028 17.6 41.5 3.1 7.9 0.2 9.2 8 1 1 9 9 9 2 AN1-like Zinc finger zf-H2C2_5 PF13909.4 001128691.1_16123001_3 - 0.0056 16.3 7.0 0.018 14.6 1.3 9.1 8 2 0 8 8 7 2 C2H2-type zinc-finger domain DZR PF12773.5 001128691.1_16123001_3 - 0.0062 16.4 35.0 1.6e+04 -17.7 34.9 5.4 1 1 0 1 1 0 0 Double zinc ribbon zf-C2HC_2 PF13913.4 001128691.1_16123001_3 - 0.0082 15.9 45.8 0.016 15.0 0.1 9.1 10 0 0 10 10 10 3 zinc-finger of a C2HC-type CpXC PF14353.4 001128691.1_16123001_3 - 0.011 15.6 30.4 4.3 7.3 0.1 8.0 1 1 5 8 8 8 0 CpXC protein zf-C2HE PF16278.3 001128691.1_16123001_3 - 0.051 13.9 60.4 0.16 12.3 2.0 8.9 1 1 6 7 7 7 0 C2HE / C2H2 / C2HC zinc-binding finger C1_4 PF07975.10 001128691.1_16123001_3 - 0.051 13.7 35.5 0.49 10.6 1.0 6.3 3 2 4 7 7 6 0 TFIIH C1-like domain zf-trcl PF13451.4 001128691.1_16123001_3 - 0.61 9.9 37.9 17 5.2 3.6 8.2 7 2 0 7 7 7 0 Probable zinc-ribbon domain LIM PF00412.20 001128691.1_16123001_3 - 0.63 10.2 38.9 2.9 8.1 1.0 7.6 3 3 4 7 7 7 0 LIM domain DUF3268 PF11672.6 001128691.1_16123001_3 - 1.1 9.5 23.8 1.1 9.4 0.3 4.7 2 2 1 5 5 5 0 zinc-finger-containing domain zf-LYAR PF08790.9 001128691.1_16123001_3 - 1.7 8.5 41.8 1.9 8.3 1.0 8.7 9 0 0 9 9 9 0 LYAR-type C2HC zinc finger zf-Sec23_Sec24 PF04810.13 001128691.1_16123001_3 - 2.4 8.1 0.0 2.4 8.1 0.0 5.7 8 0 0 8 8 8 0 Sec23/Sec24 zinc finger Zn_Tnp_IS1595 PF12760.5 001128691.1_16123001_3 - 7 6.6 46.4 2.8 7.9 5.2 6.7 3 2 2 7 7 7 0 Transposase zinc-ribbon domain Snapin_Pallidin PF14712.4 001080697.2_16122001_2 - 1.8e-22 79.5 3.7 3.7e-22 78.4 3.7 1.6 1 0 0 1 1 1 1 Snapin/Pallidin C2 PF00168.28 200875.2_16129001_1 - 8.1e-101 331.1 3.1 6e-20 71.3 0.0 8.5 7 1 0 7 7 7 7 C2 domain FerB PF08150.10 200875.2_16129001_1 - 4.7e-31 107.1 0.3 2e-30 105.1 0.2 2.2 2 0 0 2 2 2 1 FerB (NUC096) domain Ferlin_C PF16165.3 200875.2_16129001_1 - 1.7e-27 96.1 0.8 1.8e-24 86.3 0.0 2.5 1 1 1 2 2 2 2 Ferlin C-terminus FerA PF08165.9 200875.2_16129001_1 - 5.1e-21 74.2 0.6 2.3e-20 72.2 0.6 2.2 1 0 0 1 1 1 1 FerA (NUC095) domain FerI PF08151.10 200875.2_16129001_1 - 6.4e-21 74.1 1.0 1.4e-20 73.0 1.0 1.6 1 0 0 1 1 1 1 FerI (NUC094) domain PI3K_C2 PF00792.22 200875.2_16129001_1 - 0.0019 18.1 0.4 3.1 7.7 0.0 3.0 2 0 0 2 2 2 2 Phosphoinositide 3-kinase C2 B9-C2 PF07162.9 200875.2_16129001_1 - 0.013 15.6 0.2 10 6.1 0.0 3.6 3 0 0 3 3 3 0 Ciliary basal body-associated, B9 protein Pex24p PF06398.9 200875.2_16129001_1 - 0.1 11.4 32.0 0.047 12.5 0.2 3.2 2 1 1 3 3 3 0 Integral peroxisomal membrane peroxin BTB_3 PF16017.3 001347897.1_16127001_1 - 6e-51 170.8 0.0 1.2e-50 169.9 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.20 001347897.1_16127001_1 - 0.0024 18.1 0.0 0.005 17.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain NMD3 PF04981.11 001013569.2_16124001_1 - 3.9e-80 268.7 10.8 6.1e-80 268.0 10.8 1.3 1 0 0 1 1 1 1 NMD3 family ZFYVE21_C PF16696.3 001160346.1_16123001_1 - 8.7e-51 170.8 0.0 1.2e-50 170.3 0.0 1.2 1 0 0 1 1 1 1 Zinc finger FYVE domain-containing protein 21 C-terminus FYVE PF01363.19 001160346.1_16123001_1 - 1.8e-15 56.7 21.7 4.1e-15 55.5 21.7 1.7 1 0 0 1 1 1 1 FYVE zinc finger Nup153 PF08604.8 001326384.1_16129001_3 - 1.9e-214 713.1 48.3 1.9e-214 713.1 48.3 4.3 2 1 3 5 5 5 1 Nucleoporin Nup153-like zf-RanBP PF00641.16 001326384.1_16129001_3 - 3.2e-36 122.2 38.5 2e-10 39.7 2.8 4.6 4 0 0 4 4 4 4 Zn-finger in Ran binding protein and others Ig_3 PF13927.4 001083823.2_16124001_2 - 4e-32 110.5 4.5 5e-13 49.3 0.2 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001083823.2_16124001_2 - 2.6e-25 88.4 6.9 5.1e-11 42.6 0.1 4.0 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 001083823.2_16124001_2 - 7.6e-21 73.9 1.4 1.1e-07 31.7 0.1 4.1 3 2 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 001083823.2_16124001_2 - 1.1e-18 67.0 8.4 5.1e-09 36.1 0.5 3.9 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001083823.2_16124001_2 - 2.3e-17 63.0 10.3 2.7e-06 27.4 0.1 5.4 3 2 2 5 5 5 5 Immunoglobulin V-set domain Izumo-Ig PF16706.3 001083823.2_16124001_2 - 2.4e-08 33.8 0.0 0.013 15.4 0.0 3.4 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain Ig_5 PF16681.3 001083823.2_16124001_2 - 9.7e-08 32.2 4.0 0.00018 21.7 0.0 3.3 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 001083823.2_16124001_2 - 6.9e-06 26.2 0.5 0.32 11.3 0.0 3.4 3 0 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain MSC PF09402.8 001083823.2_16124001_2 - 0.00051 19.5 0.1 0.00068 19.1 0.1 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain C1-set PF07654.13 001083823.2_16124001_2 - 0.0038 17.5 0.1 0.34 11.3 0.0 3.2 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Receptor_2B4 PF11465.6 001083823.2_16124001_2 - 0.0048 17.0 0.6 0.49 10.5 0.1 3.3 2 1 1 3 3 3 1 Natural killer cell receptor 2B4 CDP-OH_P_transf PF01066.19 001195246.1_16123001_1 - 1e-11 45.3 2.7 1e-11 45.3 2.7 2.9 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF4267 PF14087.4 001195246.1_16123001_1 - 0.015 15.3 1.5 0.017 15.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4267) DUF2528 PF10800.6 001195246.1_16123001_1 - 0.083 13.3 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2528) DUF4211 PF13926.4 199822.1_16125001_1 - 1.4e-26 93.1 0.5 3.9e-26 91.7 0.5 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4211) MPP6 PF10175.7 001003618.1_16123001_2 - 3e-41 140.9 10.0 3e-41 140.9 10.0 2.0 2 0 0 2 2 2 1 M-phase phosphoprotein 6 Ku_C PF03730.12 001003618.1_16123001_2 - 4.1 8.0 9.1 0.12 13.0 2.2 2.0 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm COX5B PF01215.17 001002163.1_16122001_3 - 4.2e-28 97.5 0.0 6e-28 97.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb DUF35_N PF12172.6 001002163.1_16122001_3 - 0.17 11.6 0.2 0.17 11.6 0.2 2.4 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) BLOC1_2 PF10046.7 001033101.2_16123001_1 - 4.6e-36 122.9 7.4 6.8e-36 122.3 7.4 1.3 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF948 PF06103.9 001033101.2_16123001_1 - 0.065 13.4 0.2 0.12 12.5 0.2 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) XhlA PF10779.7 001033101.2_16123001_1 - 0.11 12.6 0.5 0.11 12.6 0.5 2.6 3 0 0 3 3 3 0 Haemolysin XhlA Homeobox PF00046.27 001009887.2_16123001_1 - 1.3e-21 76.1 7.0 1.3e-21 76.1 7.0 1.7 2 0 0 2 2 2 1 Homeobox domain QLQ PF08880.9 001009887.2_16123001_1 - 0.0027 17.3 0.4 0.005 16.4 0.4 1.4 1 0 0 1 1 1 1 QLQ NOA36 PF06524.10 001009887.2_16123001_1 - 0.0083 15.4 1.7 0.011 15.0 1.7 1.1 1 0 0 1 1 1 1 NOA36 protein Astro_capsid_p PF12226.6 001009887.2_16123001_1 - 0.075 12.0 3.2 0.11 11.5 3.2 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RNA_pol_3_Rpc31 PF11705.6 001009887.2_16123001_1 - 0.098 12.7 7.7 0.15 12.2 7.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF4746 PF15928.3 001009887.2_16123001_1 - 0.23 10.7 7.6 0.31 10.3 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Ycf1 PF05758.10 001009887.2_16123001_1 - 0.33 8.6 2.7 0.44 8.2 2.7 1.0 1 0 0 1 1 1 0 Ycf1 DFRP_C PF16543.3 001009887.2_16123001_1 - 0.34 11.3 7.9 0.59 10.5 7.9 1.4 1 0 0 1 1 1 0 DRG Family Regulatory Proteins, Tma46 Nucleo_P87 PF07267.9 001009887.2_16123001_1 - 1 8.0 4.0 1.4 7.6 4.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 VID27 PF08553.8 001009887.2_16123001_1 - 1.2 7.5 6.9 1.5 7.1 6.9 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein CENP-B_dimeris PF09026.8 001009887.2_16123001_1 - 1.9 8.8 9.5 3.3 8.0 9.5 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Ribosomal_60s PF00428.17 001009887.2_16123001_1 - 4.4 7.8 12.1 9.6 6.7 12.1 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein Ribosomal_L11_N PF03946.12 001009887.2_16123001_2 - 0.26 11.0 1.1 0.47 10.1 1.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L11, N-terminal domain Fmp27_WPPW PF10359.7 001328105.1_16122001_1 - 0.038 12.7 0.7 0.049 12.4 0.7 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Yippee-Mis18 PF03226.12 001128240.1_16122001_3 - 0.0098 15.9 0.0 0.045 13.8 0.0 2.1 1 1 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Glyco_hydro_81 PF03639.11 001128240.1_16122001_3 - 0.25 9.8 1.1 0.34 9.4 1.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 81 DUF737 PF05300.9 001089331.1_16125001_3 - 3.5e-57 193.9 45.2 2.4e-56 191.1 45.2 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF737) APOC4 PF15119.4 001135978.1_16121001_2 - 0.0029 17.7 0.1 0.0048 17.0 0.1 1.4 1 0 0 1 1 1 1 Apolipoprotein C4 UBA PF00627.29 001110283.2_16124001_2 - 6.7e-19 67.3 1.1 8.7e-10 38.2 0.0 2.4 2 0 0 2 2 2 2 UBA/TS-N domain Rad60-SLD_2 PF13881.4 001110283.2_16124001_2 - 0.0085 16.1 0.5 0.018 15.0 0.5 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.8 001110283.2_16124001_2 - 0.0092 15.6 0.1 2.3 7.9 0.0 2.7 2 0 0 2 2 2 2 Fungal ubiquitin-associated domain ubiquitin PF00240.21 001110283.2_16124001_2 - 0.025 14.2 0.7 0.096 12.3 0.7 2.1 1 1 1 2 2 2 0 Ubiquitin family UBA_2 PF08587.9 001110283.2_16124001_2 - 0.026 14.5 0.1 0.075 13.1 0.1 1.8 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) CENP-R PF06729.10 001328132.1_16122001_1 - 2.9e-08 33.6 0.3 5.6e-08 32.7 0.3 1.5 1 0 0 1 1 1 1 Kinetochore component, CENP-R SspO PF08175.10 001328132.1_16122001_1 - 0.0084 16.4 0.1 0.018 15.4 0.1 1.5 1 0 0 1 1 1 1 Small acid-soluble spore protein O family DltD_N PF04915.10 001328132.1_16122001_1 - 0.071 13.0 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 DltD N-terminal region Pkinase PF00069.23 001045089.2_16125001_3 - 3.4e-78 262.5 0.4 4.6e-78 262.1 0.4 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001045089.2_16125001_3 - 1.1e-46 159.1 0.4 1.5e-46 158.6 0.4 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001045089.2_16125001_3 - 2.9e-08 33.2 0.9 4.7e-08 32.5 0.9 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001045089.2_16125001_3 - 6.6e-05 22.2 0.0 0.00017 20.9 0.0 1.6 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.20 001045089.2_16125001_3 - 0.033 13.7 0.8 0.056 12.9 0.8 1.3 1 0 0 1 1 1 0 RIO1 family Tom37 PF10568.7 001007280.1_16123001_3 - 3e-44 150.3 0.0 5.6e-44 149.4 0.0 1.5 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.2 001007280.1_16123001_3 - 4.6e-21 75.3 0.0 8.5e-21 74.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.2 001007280.1_16123001_3 - 7.7e-21 73.5 0.2 1.5e-20 72.6 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 001007280.1_16123001_3 - 0.00017 21.3 0.0 0.00038 20.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain RabGAP-TBC PF00566.16 001007280.1_16123001_3 - 0.015 14.8 0.1 0.025 14.1 0.1 1.3 1 0 0 1 1 1 0 Rab-GTPase-TBC domain LIM PF00412.20 001099978.1_16126001_1 - 9.2e-42 141.0 69.4 1.1e-09 38.3 8.5 5.5 5 0 0 5 5 5 5 LIM domain TRIC PF05197.11 200176.1_16125001_1 - 1.4e-79 265.9 4.3 3.8e-79 264.5 4.3 1.8 1 0 0 1 1 1 1 TRIC channel Peptidase_C1 PF00112.21 214722.1_16127001_3 - 3.9e-63 213.3 1.8 5.6e-63 212.8 1.8 1.2 1 0 0 1 1 1 1 Papain family cysteine protease CathepsinC_exc PF08773.9 214722.1_16127001_3 - 4.2e-47 159.3 2.2 7.4e-47 158.4 2.2 1.4 1 0 0 1 1 1 1 Cathepsin C exclusion domain Propeptide_C1 PF08127.11 214722.1_16127001_3 - 0.0011 18.7 0.0 0.0024 17.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.13 214722.1_16127001_3 - 0.0023 16.6 3.4 0.013 14.2 0.1 2.3 3 0 0 3 3 3 2 Peptidase C1-like family Coilin_N PF15862.3 207075.1_16125001_1 - 1.2 8.7 19.5 2.1 8.0 19.5 1.3 1 0 0 1 1 1 0 Coilin N-terminus Reo_sigmaC PF04582.10 207075.1_16125001_2 - 0.0011 18.3 10.7 0.0043 16.4 10.3 1.9 1 1 0 1 1 1 1 Reovirus sigma C capsid protein NPV_P10 PF05531.10 207075.1_16125001_2 - 0.027 14.8 2.5 0.066 13.6 0.8 2.6 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.9 207075.1_16125001_2 - 0.38 10.9 1.5 22 5.3 0.1 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) COG2 PF06148.9 207075.1_16125001_2 - 0.53 10.2 7.3 2.8 7.9 0.6 3.1 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Baculo_PEP_C PF04513.10 207075.1_16125001_2 - 0.61 10.0 6.3 2.6 7.9 0.6 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus IncA PF04156.12 207075.1_16125001_2 - 5.1 6.7 19.6 0.055 13.1 6.6 3.1 2 2 1 3 3 3 0 IncA protein Glycos_transf_4 PF00953.19 001089411.1_16125001_2 - 1.2e-32 112.9 17.0 1.2e-32 112.9 17.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 4 Gal-bind_lectin PF00337.20 001001817.1_16126001_3 - 1.9e-78 260.3 1.2 1.3e-40 137.9 0.0 2.2 2 0 0 2 2 2 2 Galactoside-binding lectin DUF1080 PF06439.9 001001817.1_16126001_3 - 0.014 15.4 0.0 2.5 8.0 0.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1080) PID PF00640.21 001014343.2_16125001_1 - 8.6e-08 32.2 0.1 1.7e-07 31.2 0.1 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) ETRAMP PF09716.8 001014343.2_16125001_3 - 0.16 11.9 9.8 0.3 11.1 9.8 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) AhpC-TSA PF00578.19 001089425.1_16122001_2 - 3.9e-36 123.5 0.0 6.7e-36 122.8 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.7 001089425.1_16122001_2 - 3e-13 49.2 0.0 6.6e-13 48.1 0.0 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.8 001089425.1_16122001_2 - 9e-12 44.8 0.0 1.4e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Redoxin COX4 PF02936.12 214701.1_16122001_2 - 5.9e-58 194.7 0.6 7.2e-58 194.4 0.6 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV Molybdop_Fe4S4 PF04879.14 214701.1_16122001_2 - 0.17 11.8 1.7 1.6 8.6 0.7 2.2 2 0 0 2 2 2 0 Molybdopterin oxidoreductase Fe4S4 domain BTB PF00651.29 214797.1_16126001_1 - 7e-19 68.0 0.3 1.3e-18 67.1 0.3 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 214797.1_16126001_1 - 6.6e-11 41.9 48.6 0.13 12.7 1.0 9.1 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 214797.1_16126001_1 - 4e-06 27.0 62.9 0.16 12.8 0.6 10.4 10 0 0 10 10 10 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 214797.1_16126001_1 - 5.4e-05 23.3 7.1 0.00026 21.2 3.4 8.1 8 0 0 8 8 8 2 Zinc-finger double domain zf-C2H2_jaz PF12171.6 214797.1_16126001_1 - 0.00029 20.9 18.0 0.022 15.0 0.1 6.4 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 214797.1_16126001_1 - 0.0018 18.4 3.0 0.0018 18.4 3.0 6.4 4 2 4 8 8 8 2 Drought induced 19 protein (Di19), zinc-binding CpXC PF14353.4 214797.1_16126001_1 - 0.015 15.2 13.2 2.7 7.9 0.0 5.2 4 1 1 5 5 5 0 CpXC protein zf-met PF12874.5 214797.1_16126001_1 - 0.07 13.4 39.7 1.1 9.6 0.6 9.0 9 0 0 9 9 9 0 Zinc-finger of C2H2 type MACPF PF01823.17 001327926.1_16125001_1 - 2.7e-28 99.4 1.3 3.9e-28 98.8 0.1 1.7 2 0 0 2 2 2 1 MAC/Perforin domain Ldl_recept_a PF00057.16 001327926.1_16125001_1 - 2.2e-07 30.9 11.3 8.6e-07 28.9 11.3 2.2 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A TSP_1 PF00090.17 001327926.1_16125001_1 - 6.7e-06 26.1 27.3 0.00045 20.3 4.5 3.6 3 0 0 3 3 3 2 Thrombospondin type 1 domain EF-hand_7 PF13499.4 205693.1_16124001_2 - 1.1e-08 35.2 1.7 5.2e-05 23.5 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 205693.1_16124001_2 - 1.3e-07 30.5 1.8 5.9e-06 25.3 0.1 3.2 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.4 205693.1_16124001_2 - 6.9e-07 28.6 0.2 1.9e-05 24.1 0.0 3.1 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.4 205693.1_16124001_2 - 0.00013 21.5 1.2 0.00049 19.7 0.5 2.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.4 205693.1_16124001_2 - 0.0017 17.6 0.1 0.0062 15.9 0.0 1.9 2 0 0 2 2 2 1 EF hand FERM_M PF00373.16 001045356.2_16122001_1 - 1.5e-15 57.5 0.2 4.1e-15 56.1 0.1 1.7 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.8 001045356.2_16122001_1 - 1.5e-12 47.1 0.1 3.2e-12 46.1 0.1 1.6 1 0 0 1 1 1 1 FERM N-terminal domain 7tm_3 PF00003.20 001324456.1_16125001_2 - 6.3e-32 111.1 16.6 6.3e-32 111.1 16.6 2.3 2 0 0 2 2 2 2 7 transmembrane sweet-taste receptor of 3 GCPR AIG1 PF04548.14 001130660.1_16123001_1 - 4.5e-42 143.6 2.0 6.6e-42 143.1 2.0 1.2 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.21 001130660.1_16123001_1 - 3.6e-08 33.3 0.3 1.4e-07 31.5 0.1 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF2407_C PF13373.4 001130660.1_16123001_1 - 0.019 15.0 0.8 0.034 14.2 0.1 1.7 2 0 0 2 2 2 0 DUF2407 C-terminal domain DUF258 PF03193.14 001130660.1_16123001_1 - 0.031 14.1 0.8 0.031 14.1 0.8 2.8 2 1 0 3 3 3 0 Protein of unknown function, DUF258 ABC_tran PF00005.25 001130660.1_16123001_1 - 0.071 13.5 4.2 0.38 11.1 4.2 2.4 1 1 0 1 1 1 0 ABC transporter TMEM65 PF10507.7 001130660.1_16123001_1 - 0.73 9.7 3.8 3 7.7 0.0 2.4 2 0 0 2 2 2 0 Transmembrane protein 65 Dynamin_N PF00350.21 001130660.1_16123001_1 - 2.5 8.0 8.4 8.1 6.3 0.3 3.4 2 2 1 3 3 3 0 Dynamin family DUF883 PF05957.11 001130660.1_16123001_1 - 3.6 8.1 17.4 0.33 11.4 0.9 3.4 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) TB2_DP1_HVA22 PF03134.17 001037575.1_16124001_3 - 4.6e-26 90.4 10.4 7.3e-26 89.8 10.4 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF2304 PF10066.7 001037575.1_16124001_3 - 0.47 10.6 2.7 0.83 9.8 2.7 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) Peptidase_C78 PF07910.11 001089530.1_16123001_2 - 1.9e-49 167.9 0.0 2.3e-49 167.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C54 PF03416.17 001089530.1_16123001_2 - 0.033 13.5 1.8 2.2 7.5 0.3 2.3 2 1 0 2 2 2 0 Peptidase family C54 WAK_assoc PF14380.4 001089530.1_16123001_2 - 0.13 12.9 2.1 0.37 11.4 2.1 1.8 1 1 0 1 1 1 0 Wall-associated receptor kinase C-terminal ParA PF10609.7 001002442.1_16123001_3 - 2.2e-98 328.5 0.5 2.7e-98 328.2 0.5 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.21 001002442.1_16123001_3 - 2.9e-10 40.2 0.0 5e-10 39.4 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.4 001002442.1_16123001_3 - 1.7e-08 34.4 0.3 1.4e-06 28.2 0.1 2.2 2 0 0 2 2 2 1 AAA domain Fer4_NifH PF00142.16 001002442.1_16123001_3 - 9.5e-07 28.4 0.1 0.029 13.7 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MipZ PF09140.9 001002442.1_16123001_3 - 3.2e-05 23.2 0.0 4.9e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.13 001002442.1_16123001_3 - 0.00016 20.9 1.1 0.0078 15.3 0.4 2.8 2 1 0 3 3 3 1 Anion-transporting ATPase AAA_25 PF13481.4 001002442.1_16123001_3 - 0.072 12.5 0.9 0.21 11.0 0.1 2.0 3 0 0 3 3 3 0 AAA domain Pou PF00157.15 001199683.1_16125001_1 - 3.5e-38 129.3 0.2 7.1e-38 128.3 0.2 1.6 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 001199683.1_16125001_1 - 2.1e-16 59.3 3.1 4.2e-16 58.4 3.1 1.5 1 0 0 1 1 1 1 Homeobox domain DUF4201 PF13870.4 001006061.1_16123001_1 - 8.4e-38 129.6 29.2 8.4e-38 129.6 29.2 2.5 1 1 1 2 2 2 1 Domain of unknown function (DUF4201) DUF2097 PF09870.7 001006061.1_16123001_1 - 0.0081 16.2 0.6 0.025 14.7 0.6 1.9 1 1 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2097) VirE1 PF12189.6 001006061.1_16123001_1 - 0.17 11.9 0.6 0.78 9.8 0.0 2.4 3 0 0 3 3 3 0 Single-strand DNA-binding protein DUF1863 PF08937.9 001006061.1_16123001_1 - 0.6 10.3 7.5 8.3 6.6 2.0 2.7 2 0 0 2 2 2 0 MTH538 TIR-like domain (DUF1863) RNA_pol_Rpb2_6 PF00562.26 001006061.1_16123001_1 - 2.8 6.7 8.0 2.4 7.0 6.9 1.4 1 1 0 1 1 1 0 RNA polymerase Rpb2, domain 6 AIG1 PF04548.14 001079659.2_16124001_2 - 2e-19 69.6 0.0 5.1e-19 68.3 0.0 1.6 1 1 0 1 1 1 1 AIG1 family DUF4191 PF13829.4 001079659.2_16124001_2 - 0.03 13.5 1.7 1.4 8.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) LSM PF01423.20 001110123.1_16124001_1 - 9.4e-11 41.1 0.6 1.3e-10 40.6 0.6 1.2 1 0 0 1 1 1 1 LSM domain Oscp1 PF10188.7 001110123.1_16124001_2 - 3.1e-72 242.2 1.6 4.2e-72 241.8 1.6 1.2 1 0 0 1 1 1 1 Organic solute transport protein 1 dNK PF01712.17 001007056.1_16123001_1 - 1.4e-70 237.1 1.1 1.7e-70 236.9 1.1 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.4 001007056.1_16123001_1 - 9.8e-06 26.0 0.6 0.00053 20.4 0.2 2.7 1 1 1 2 2 2 1 AAA domain AAA_28 PF13521.4 001007056.1_16123001_1 - 0.0011 19.1 0.1 0.0019 18.3 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.4 001007056.1_16123001_1 - 0.0016 18.5 0.0 0.014 15.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.15 001007056.1_16123001_1 - 0.0086 15.6 0.0 0.082 12.4 0.0 2.1 2 0 0 2 2 2 1 Thymidylate kinase AAA_17 PF13207.4 001007056.1_16123001_1 - 0.13 12.6 0.0 0.34 11.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF5013 PF16405.3 001007056.1_16123001_2 - 0.17 12.0 0.0 0.26 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5013) Kelch_3 PF13415.4 212739.1_16125001_2 - 1.2e-25 89.1 9.0 4.6e-08 33.0 0.1 6.5 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.4 212739.1_16125001_2 - 3.4e-25 87.6 2.7 1.1e-07 31.6 0.0 5.6 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.4 212739.1_16125001_2 - 2.5e-19 68.7 2.8 2e-06 27.5 0.1 6.7 7 0 0 7 7 7 3 Kelch motif Kelch_6 PF13964.4 212739.1_16125001_2 - 1.4e-17 63.2 7.2 0.0002 21.4 0.2 5.5 4 1 1 5 5 5 4 Kelch motif Kelch_1 PF01344.23 212739.1_16125001_2 - 8.4e-16 57.2 1.9 0.00043 19.7 0.0 5.6 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.13 212739.1_16125001_2 - 1e-15 56.9 10.2 2.6e-05 23.9 0.2 6.3 6 0 0 6 6 6 3 Kelch motif F-box-like PF12937.5 212739.1_16125001_2 - 1.5e-09 37.4 0.0 5.4e-09 35.7 0.0 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 212739.1_16125001_2 - 2.6e-06 27.0 0.0 2.6e-06 27.0 0.0 2.5 3 0 0 3 3 3 1 F-box domain Herpes_pp85 PF04637.10 212739.1_16125001_2 - 8.2 4.6 6.3 12 4.0 6.3 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) PP2C PF00481.19 001320183.1_16126001_2 - 2e-59 201.2 0.0 2.7e-59 200.8 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.4 001320183.1_16126001_2 - 3.2e-09 36.6 0.0 1e-08 35.0 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.10 001320183.1_16126001_2 - 0.01 15.7 0.0 0.084 12.6 0.0 2.0 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) Ion_trans PF00520.29 199802.1_16127001_3 - 3.9e-43 147.3 15.0 5.6e-43 146.8 15.0 1.2 1 0 0 1 1 1 1 Ion transport protein DUF3399 PF11879.6 199802.1_16127001_3 - 5.9e-39 132.5 5.9 1.4e-38 131.3 5.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3399) BTB_2 PF02214.20 199802.1_16127001_3 - 2.7e-28 98.0 0.1 6.6e-28 96.8 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain Shal-type PF11601.6 199802.1_16127001_3 - 1.3e-13 50.1 13.3 2.6e-13 49.1 13.3 1.5 1 0 0 1 1 1 1 Shal-type voltage-gated potassium channels, N-terminal Ion_trans_2 PF07885.14 199802.1_16127001_3 - 5.4e-13 48.6 5.7 5.4e-13 48.6 5.7 2.3 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.3 199802.1_16127001_3 - 4e-05 23.5 0.0 0.0002 21.3 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain PKD_channel PF08016.10 199802.1_16127001_3 - 0.0081 14.7 8.6 0.014 14.0 8.6 1.3 1 0 0 1 1 1 1 Polycystin cation channel Cytochrom_B_C PF00032.15 199802.1_16127001_3 - 6.4 7.0 6.7 4.4 7.5 0.6 2.4 1 1 1 2 2 2 0 Cytochrome b(C-terminal)/b6/petD WD40 PF00400.30 001328559.1_16126001_2 - 4.3e-31 106.4 4.0 6.9e-06 26.6 0.0 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat CSTF1_dimer PF16699.3 001328559.1_16126001_2 - 7.6e-22 76.7 0.2 1.3e-21 76.0 0.2 1.4 1 0 0 1 1 1 1 Cleavage stimulation factor subunit 1, dimerisation domain ANAPC4_WD40 PF12894.5 001328559.1_16126001_2 - 5.7e-11 42.4 0.0 0.057 13.6 0.0 4.6 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain TMEM51 PF15345.4 001102617.1_16123001_2 - 4.9e-90 301.4 0.4 6.2e-90 301.1 0.4 1.1 1 0 0 1 1 1 1 Transmembrane protein 51 TMEM61 PF15105.4 001102617.1_16123001_2 - 0.00074 19.3 0.9 0.0016 18.1 0.1 2.0 2 1 0 2 2 2 1 TMEM61 protein family RCR PF12273.6 001102617.1_16123001_2 - 0.097 13.2 8.3 0.064 13.8 5.2 2.0 1 1 1 2 2 2 0 Chitin synthesis regulation, resistance to Congo red TMEM100 PF16311.3 001102617.1_16123001_2 - 0.28 10.6 3.8 0.69 9.4 2.3 2.0 1 1 1 2 2 2 0 Transmembrane protein 100 Trp_oprn_chp PF09534.8 001102617.1_16123001_2 - 0.3 10.7 2.8 0.48 10.0 2.8 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) SMK-1 PF04802.13 200001.2_16126001_2 - 6e-76 254.5 3.5 1.5e-75 253.2 3.5 1.7 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 WH1 PF00568.21 200001.2_16126001_2 - 0.015 15.1 0.0 0.03 14.1 0.0 1.5 1 0 0 1 1 1 0 WH1 domain Diphtheria_T PF02764.12 200001.2_16126001_2 - 0.029 14.3 0.0 0.068 13.0 0.0 1.5 1 0 0 1 1 1 0 Diphtheria toxin, T domain Clathrin_bdg PF15045.4 001145561.1_16126001_3 - 7.6e-19 67.3 0.0 1.9e-18 66.0 0.0 1.7 1 0 0 1 1 1 1 Clathrin-binding box of Aftiphilin, vesicle trafficking zf-C3H1 PF10650.7 212725.1_16125001_1 - 0.016 14.8 1.6 0.016 14.8 1.6 2.2 2 0 0 2 2 2 0 Putative zinc-finger domain ILEI PF15711.3 212725.1_16125001_2 - 2.9e-28 98.0 0.1 4.8e-28 97.3 0.1 1.4 1 0 0 1 1 1 1 Interleukin-like EMT inducer Clat_adaptor_s PF01217.18 205558.1_16124001_2 - 5.6e-58 194.8 2.7 5.6e-58 194.8 2.7 2.0 3 0 0 3 3 3 1 Clathrin adaptor complex small chain TNFR_c6 PF00020.16 001042688.2_16126001_3 - 2.3e-16 59.8 32.4 9.2e-07 29.0 10.7 4.7 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region Death PF00531.20 001042688.2_16126001_3 - 1.7e-09 37.6 0.3 3.1e-09 36.7 0.3 1.4 1 0 0 1 1 1 1 Death domain Ephrin_rec_like PF07699.11 001042688.2_16126001_3 - 0.0017 17.9 27.9 0.0081 15.8 0.8 3.8 3 1 0 3 3 3 2 Putative ephrin-receptor like NCD3G PF07562.12 001042688.2_16126001_3 - 0.96 9.4 23.5 0.63 9.9 9.9 3.3 2 2 1 3 3 3 0 Nine Cysteines Domain of family 3 GPCR DHR-2 PF06920.11 001202493.1_16129001_1 - 1.2e-203 677.4 14.9 2.1e-203 676.7 14.9 1.4 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.4 001202493.1_16129001_1 - 3.6e-51 173.6 0.3 1.3e-50 171.7 0.3 2.1 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.6 001202493.1_16129001_1 - 4e-34 116.7 0.1 9e-34 115.6 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PH PF00169.27 001202493.1_16129001_1 - 7.1e-13 48.8 0.2 2.1e-12 47.3 0.2 1.9 1 0 0 1 1 1 1 PH domain PPR_long PF17177.2 001202493.1_16129001_1 - 0.0051 16.1 2.8 0.11 11.7 0.2 2.8 2 1 0 2 2 2 1 Pentacotripeptide-repeat region of PROPR zf-H2C2_2 PF13465.4 001128282.1_16124001_2 - 9.6e-31 104.7 44.0 1.8e-09 37.5 0.1 7.1 6 0 0 6 6 6 6 Zinc-finger double domain zf-C2H2 PF00096.24 001128282.1_16124001_2 - 4.9e-20 70.7 46.5 0.00014 22.0 0.2 6.5 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001128282.1_16124001_2 - 1.8e-18 65.5 44.7 0.006 17.2 0.5 6.5 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001128282.1_16124001_2 - 2.2e-08 34.1 29.4 0.016 15.4 0.7 6.5 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 001128282.1_16124001_2 - 4.3e-06 26.6 18.0 0.0039 17.1 2.2 4.1 3 0 0 3 3 3 2 Zinc ribbon domain zf-met PF12874.5 001128282.1_16124001_2 - 0.00066 19.9 33.2 0.21 11.9 1.3 6.4 6 0 0 6 6 6 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 001128282.1_16124001_2 - 0.0011 18.6 12.9 0.0035 16.9 1.2 4.8 5 0 0 5 5 5 2 zinc-finger C2H2-type zf-Di19 PF05605.10 001128282.1_16124001_2 - 0.0017 18.4 30.4 0.022 14.9 8.5 4.7 3 2 1 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding CpXC PF14353.4 001128282.1_16124001_2 - 0.04 13.8 14.0 0.16 11.8 1.7 4.0 2 1 2 4 4 4 0 CpXC protein zinc_ribbon_15 PF17032.3 001128282.1_16124001_2 - 0.043 14.4 18.9 0.8 10.4 2.2 3.6 1 1 2 3 3 3 0 zinc-ribbon family zf-C2H2_2 PF12756.5 001128282.1_16124001_2 - 0.86 9.8 29.2 6.4 7.0 1.5 5.9 1 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) Elf1 PF05129.11 001128282.1_16124001_2 - 1.3 8.9 23.8 6.6 6.7 0.3 4.5 1 1 3 4 4 4 0 Transcription elongation factor Elf1 like zf-C2H2_6 PF13912.4 001128282.1_16124001_2 - 2.1 8.3 39.4 4.4 7.2 0.1 6.4 6 0 0 6 6 6 0 C2H2-type zinc finger zf-CCHC_2 PF13696.4 001128282.1_16124001_2 - 3.6 7.3 8.1 18 5.1 0.1 3.5 3 0 0 3 3 3 0 Zinc knuckle PyrI_C PF02748.13 001128282.1_16124001_2 - 3.9 7.3 23.0 2.2 8.1 0.2 5.7 3 2 2 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF2225 PF09986.7 001128282.1_16124001_2 - 7.3 6.1 13.9 6.3 6.3 2.2 3.4 2 2 2 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) PIG-X PF08320.10 001126436.1_16122001_2 - 4.6e-37 127.8 0.3 5.9e-37 127.5 0.3 1.1 1 0 0 1 1 1 1 PIG-X / PBN1 PWWP PF00855.15 001083030.1_16128001_1 - 5.7e-05 23.4 0.0 0.00011 22.5 0.0 1.4 1 0 0 1 1 1 1 PWWP domain zf-HC5HC2H_2 PF13832.4 001083030.1_16128001_3 - 1.4e-35 121.6 5.5 1.4e-35 121.6 5.5 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.7 001083030.1_16128001_3 - 5.3e-33 114.5 4.2 5.3e-33 114.5 4.2 2.8 3 0 0 3 3 3 1 Enhancer of polycomb-like Bromodomain PF00439.23 001083030.1_16128001_3 - 7.8e-25 86.6 0.2 1.6e-24 85.7 0.2 1.5 1 0 0 1 1 1 1 Bromodomain zf-HC5HC2H PF13771.4 001083030.1_16128001_3 - 4.6e-24 84.3 4.3 4.6e-24 84.3 4.3 3.1 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.4 001083030.1_16128001_3 - 7.6e-13 47.6 4.0 7.6e-13 47.6 4.0 2.8 2 0 0 2 2 2 1 PHD-finger PHD PF00628.27 001083030.1_16128001_3 - 2.1e-07 30.6 28.4 1.1e-06 28.3 13.6 3.0 2 0 0 2 2 2 2 PHD-finger PIP49_C PF12260.6 212751.1_16124001_2 - 2.2e-59 200.1 1.9 2.2e-59 200.1 1.9 2.2 2 0 0 2 2 2 1 Protein-kinase domain of FAM69 PIP49_N PF14875.4 212751.1_16124001_2 - 5.4e-22 78.2 0.9 5.4e-22 78.2 0.9 2.1 2 0 0 2 2 2 1 N-term cysteine-rich ER, FAM69 Ion_trans PF00520.29 001195197.1_16124001_1 - 4e-46 157.1 13.4 5.1e-46 156.8 13.4 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001195197.1_16124001_1 - 7.4e-27 93.4 0.0 1.7e-26 92.2 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 001195197.1_16124001_1 - 1.2e-11 44.3 10.1 6.4e-11 42.0 2.8 2.6 2 0 0 2 2 2 2 Ion channel BTB_3 PF16017.3 001195197.1_16124001_1 - 0.0015 18.4 0.0 0.0031 17.4 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain MARVEL PF01284.21 001195197.1_16124001_1 - 0.78 9.6 5.0 1.1 9.2 0.8 2.6 2 1 0 2 2 2 0 Membrane-associating domain PKD_channel PF08016.10 001195197.1_16124001_1 - 2.4 6.6 8.1 3.4 6.1 2.6 2.1 1 1 1 2 2 2 0 Polycystin cation channel Adap_comp_sub PF00928.19 001114441.1_16126001_1 - 5.1e-87 291.4 0.8 1.4e-86 290.1 0.4 1.7 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.18 001114441.1_16126001_1 - 2.2e-09 37.2 1.9 3.7e-09 36.5 1.9 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.7 001114441.1_16126001_1 - 0.0004 19.8 0.1 0.00063 19.1 0.1 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain C2-C2_1 PF11618.6 001246660.2_16129001_2 - 9.1e-62 207.2 0.0 9.2e-53 178.0 0.1 4.2 4 0 0 4 4 4 3 First C2 domain of RPGR-interacting protein 1 C2 PF00168.28 001246660.2_16129001_2 - 1.9e-09 37.6 0.0 1e-08 35.2 0.0 2.3 2 0 0 2 2 2 1 C2 domain Melibiase_2 PF16499.3 001037388.2_16124001_1 - 3.5e-181 601.8 0.1 4.1e-181 601.6 0.1 1.0 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase PF02065.16 001037388.2_16124001_1 - 0.00016 20.6 0.0 0.0003 19.7 0.0 1.3 1 0 0 1 1 1 1 Melibiase DUF3585 PF12130.6 001033738.1_16123001_1 - 7.1e-18 64.9 13.1 1e-17 64.4 13.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3585) PI3_PI4_kinase PF00454.25 001045485.2_16125001_2 - 7.3e-63 212.6 0.0 7.3e-63 212.6 0.0 1.9 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase ATP_synth_reg PF14960.4 001200033.1_16121001_2 - 3.9e-27 93.4 0.2 5.7e-27 92.9 0.2 1.3 1 0 0 1 1 1 1 ATP synthase regulation EF-hand_11 PF08976.9 001309483.1_16129001_3 - 3.3e-62 207.7 18.0 6.4e-20 71.8 0.0 12.3 10 2 2 12 12 12 11 EF-hand domain EF-hand_7 PF13499.4 001309483.1_16129001_3 - 6.4e-48 161.0 44.7 1.6e-08 34.7 1.8 12.4 12 0 0 12 12 12 11 EF-hand domain pair EF-hand_1 PF00036.30 001309483.1_16129001_3 - 1.1e-39 130.9 25.0 0.00032 19.9 0.0 16.0 16 0 0 16 16 16 9 EF hand EF-hand_6 PF13405.4 001309483.1_16129001_3 - 1.2e-37 124.5 40.1 1.8e-05 24.2 0.0 15.0 15 0 0 15 15 15 10 EF-hand domain EF-hand_8 PF13833.4 001309483.1_16129001_3 - 8.9e-33 111.7 22.6 1.8e-05 24.3 0.2 13.0 13 0 0 13 13 13 7 EF-hand domain pair EF-hand_5 PF13202.4 001309483.1_16129001_3 - 6.6e-21 72.7 17.6 0.00089 18.5 0.0 11.9 13 0 0 13 13 13 6 EF hand EF-hand_9 PF14658.4 001309483.1_16129001_3 - 1.2e-09 38.3 0.0 0.087 13.0 0.0 7.3 6 0 0 6 6 6 2 EF-hand domain GPHH PF16905.3 001309483.1_16129001_3 - 6e-05 22.6 0.0 38 4.0 0.0 7.0 8 1 1 9 9 9 0 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_4 PF12763.5 001309483.1_16129001_3 - 0.0034 17.2 3.1 1.4 8.8 0.1 4.6 5 0 0 5 5 5 1 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.11 001309483.1_16129001_3 - 0.029 14.1 6.4 14 5.4 0.0 6.0 7 1 1 8 8 8 0 Caleosin related protein Alpha-2-MRAP_N PF06400.9 001309483.1_16129001_3 - 0.19 11.6 4.2 0.93 9.4 0.4 3.3 3 0 0 3 3 2 0 Alpha-2-macroglobulin RAP, N-terminal domain SPARC_Ca_bdg PF10591.7 001309483.1_16129001_3 - 0.74 10.0 4.4 44 4.3 0.0 4.9 6 0 0 6 6 6 0 Secreted protein acidic and rich in cysteine Ca binding region RPN13_C PF16550.3 001309483.1_16129001_3 - 1.3 9.1 5.8 16 5.6 0.0 4.2 4 0 0 4 4 4 0 UCH-binding domain Vps4_C PF09336.8 001309483.1_16129001_3 - 2 8.3 4.1 43 4.1 0.1 4.1 3 0 0 3 3 3 0 Vps4 C terminal oligomerisation domain V-set PF07686.15 001080802.1_16123001_1 - 6.6e-15 55.1 0.1 1.1e-14 54.4 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 001080802.1_16123001_1 - 4.4e-06 26.6 0.2 8.3e-06 25.8 0.2 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001080802.1_16123001_1 - 3.7e-05 23.6 0.2 0.00012 21.9 0.2 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain DUF843 PF05814.9 001080802.1_16123001_1 - 0.00034 20.4 0.5 0.025 14.4 0.1 2.3 2 0 0 2 2 2 1 Baculovirus protein of unknown function (DUF843) Ig_3 PF13927.4 001080802.1_16123001_1 - 0.0004 20.8 0.3 0.00095 19.6 0.3 1.7 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001080802.1_16123001_1 - 0.097 12.9 0.3 0.3 11.3 0.3 1.9 1 1 0 1 1 1 0 Immunoglobulin domain COX2_TM PF02790.13 001080802.1_16123001_1 - 0.41 10.7 3.4 0.21 11.6 0.3 1.9 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain NTP_transf_7 PF07984.10 001103125.1_16125001_3 - 2.9e-156 519.5 0.6 3.5e-156 519.2 0.6 1.1 1 0 0 1 1 1 1 Nucleotidyltransferase V-set PF07686.15 001128565.1_16122001_1 - 4.1e-11 42.9 0.1 6.3e-11 42.3 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001128565.1_16122001_1 - 0.00012 22.5 0.1 0.00043 20.7 0.0 1.9 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 001128565.1_16122001_1 - 0.0067 16.3 0.0 0.015 15.2 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain Surp PF01805.18 001089532.2_16127001_3 - 1.2e-19 69.9 0.2 2.8e-19 68.7 0.2 1.7 1 0 0 1 1 1 1 Surp module RRM_1 PF00076.20 001089532.2_16127001_3 - 2.6e-12 46.2 0.0 5.2e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) cwf21 PF08312.10 001089532.2_16127001_3 - 1.7e-08 34.3 4.2 5.8e-08 32.6 4.2 2.0 1 0 0 1 1 1 1 cwf21 domain CTD_bind PF04818.11 001089532.2_16127001_3 - 2.3e-05 25.0 0.2 0.0001 22.9 0.1 2.3 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CTK3 PF12243.6 001089532.2_16127001_3 - 6e-05 22.9 0.1 0.00013 21.8 0.1 1.5 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 SET_assoc PF11767.6 001089532.2_16127001_3 - 0.036 13.6 0.0 0.33 10.5 0.0 2.5 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated RRM_7 PF16367.3 001089532.2_16127001_3 - 0.037 14.0 0.0 0.092 12.7 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif WD40 PF00400.30 213099.1_16126001_1 - 5.1e-57 188.4 29.5 1.6e-09 38.1 0.2 8.9 9 0 0 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 213099.1_16126001_1 - 5.6e-24 84.1 1.6 0.00021 21.4 0.1 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 213099.1_16126001_1 - 1.9e-12 46.4 4.7 0.0045 15.5 0.2 4.6 1 1 4 5 5 5 4 Nucleoporin Nup120/160 eIF2A PF08662.9 213099.1_16126001_1 - 1.1e-10 41.6 0.0 5.2e-06 26.3 0.0 3.4 1 1 4 5 5 5 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.3 213099.1_16126001_1 - 7.5e-05 22.1 1.6 0.012 14.8 0.0 3.2 2 1 2 4 4 4 2 WD40-like domain PALB2_WD40 PF16756.3 213099.1_16126001_1 - 0.00027 19.8 1.5 7 5.3 0.0 4.1 1 1 2 4 4 4 3 Partner and localizer of BRCA2 WD40 domain EGF_CA PF07645.13 001145580.1_16125001_3 - 5.1e-20 71.3 67.1 6.1e-10 39.0 5.0 5.6 4 1 1 5 5 5 3 Calcium-binding EGF domain MAM PF00629.21 001145580.1_16125001_3 - 1.1e-18 67.4 0.0 3.3e-18 65.9 0.0 1.8 1 1 0 1 1 1 1 MAM domain, meprin/A5/mu cEGF PF12662.5 001145580.1_16125001_3 - 1.2e-17 63.4 35.3 4.1e-08 32.9 0.3 5.7 5 0 0 5 5 5 4 Complement Clr-like EGF-like FXa_inhibition PF14670.4 001145580.1_16125001_3 - 3.7e-10 39.8 67.4 0.00067 19.7 5.0 5.7 3 1 2 5 5 5 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.5 001145580.1_16125001_3 - 7.9e-10 38.6 65.0 1.7e-08 34.4 11.3 6.4 5 2 0 5 5 5 3 EGF domain EGF PF00008.25 001145580.1_16125001_3 - 0.0024 18.0 77.8 0.058 13.6 2.7 6.7 7 1 0 7 7 7 5 EGF-like domain EGF_2 PF07974.11 001145580.1_16125001_3 - 0.022 15.0 15.8 0.022 15.0 15.8 6.3 5 1 0 5 5 5 0 EGF-like domain Carb_anhydrase PF00194.19 001166211.1_16124001_3 - 2.7e-89 299.0 0.1 3.3e-89 298.7 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Glypican PF01153.17 001305618.1_16126001_2 - 6.8e-103 345.3 0.0 9e-103 344.9 0.0 1.0 1 0 0 1 1 1 1 Glypican CALCOCO1 PF07888.9 200121.2_16126001_1 - 6.7e-216 718.4 52.5 2.4e-138 462.3 8.9 2.0 1 1 1 2 2 2 2 Calcium binding and coiled-coil domain (CALCOCO1) like DUF1515 PF07439.9 200121.2_16126001_1 - 1.6 8.6 13.1 1 9.3 5.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) DUF3584 PF12128.6 200121.2_16126001_1 - 2.2 5.6 54.1 3.6 4.8 54.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Reo_sigmaC PF04582.10 200121.2_16126001_1 - 2.9 7.1 15.0 0.61 9.3 3.9 2.6 1 1 2 3 3 3 0 Reovirus sigma C capsid protein TINF2_N PF14973.4 001114472.1_16126001_3 - 3.2e-52 176.7 2.0 3.2e-52 176.7 2.0 1.6 2 0 0 2 2 2 1 TERF1-interacting nuclear factor 2 N-terminus zf-H2C2_2 PF13465.4 001114472.1_16126001_3 - 1.6e-48 160.9 109.4 3.1e-08 33.6 0.7 14.1 14 0 0 14 14 14 10 Zinc-finger double domain zf-C2H2 PF00096.24 001114472.1_16126001_3 - 2.7e-40 134.5 120.5 2.3e-05 24.5 1.6 13.9 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001114472.1_16126001_3 - 3.3e-33 111.3 109.2 0.0011 19.5 4.3 13.9 13 0 0 13 13 13 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001114472.1_16126001_3 - 9.4e-12 44.5 96.1 9.1e-05 22.2 1.1 13.5 13 0 0 13 13 13 9 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001114472.1_16126001_3 - 0.0091 15.6 0.7 0.0091 15.6 0.7 12.5 13 0 0 13 13 13 3 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 001114472.1_16126001_3 - 0.072 13.3 0.0 0.072 13.3 0.0 12.9 13 0 0 13 13 13 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_9 PF14369.4 001114472.1_16126001_3 - 1.1 9.5 0.0 1.1 9.5 0.0 9.3 11 2 1 12 12 12 0 zinc-ribbon ADK_lid PF05191.12 001114472.1_16126001_3 - 1.5 8.8 27.1 0.67 9.9 0.1 6.5 4 3 3 7 7 7 0 Adenylate kinase, active site lid zf-met PF12874.5 001114472.1_16126001_3 - 7.3 7.0 67.1 0.071 13.4 0.6 10.8 11 0 0 11 11 11 0 Zinc-finger of C2H2 type EF-hand_1 PF00036.30 200950.1_16123001_1 - 4.1e-25 85.3 4.5 1e-07 30.8 0.1 5.4 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.4 200950.1_16123001_1 - 4.9e-23 81.3 2.5 6.1e-10 39.3 1.2 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.4 200950.1_16123001_1 - 6.4e-21 72.3 4.9 4e-07 29.3 0.2 5.6 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.4 200950.1_16123001_1 - 7.8e-17 60.7 2.1 7.4e-07 28.7 0.0 5.0 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.4 200950.1_16123001_1 - 1.8e-12 46.0 6.1 0.00047 19.4 0.0 3.8 4 0 0 4 4 4 3 EF hand EF-hand_10 PF14788.4 200950.1_16123001_1 - 0.028 14.2 0.1 8.4 6.2 0.0 3.0 3 0 0 3 3 3 0 EF hand Filament PF00038.19 152973.2_16125001_2 - 2.2e-78 263.9 58.1 2.2e-78 263.9 58.1 2.1 2 0 0 2 2 2 1 Intermediate filament protein LTD PF00932.17 152973.2_16125001_2 - 4.6e-10 39.7 0.0 9e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Lamin Tail Domain DUF572 PF04502.11 152973.2_16125001_2 - 0.0014 18.1 8.6 0.0014 18.1 8.6 4.1 2 1 1 3 3 3 1 Family of unknown function (DUF572) DDHD PF02862.15 152973.2_16125001_2 - 0.016 15.2 1.4 0.016 15.2 1.4 3.5 2 1 0 2 2 2 0 DDHD domain Reo_sigmaC PF04582.10 152973.2_16125001_2 - 0.068 12.4 13.5 0.018 14.3 2.9 2.9 2 2 0 2 2 2 0 Reovirus sigma C capsid protein NPV_P10 PF05531.10 152973.2_16125001_2 - 3.3 8.1 20.9 0.42 11.0 1.3 4.0 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Dsh_C PF12316.6 212648.1_16126001_2 - 9.6e-79 264.5 29.9 9.6e-79 264.5 29.9 2.7 2 1 1 3 3 3 1 Segment polarity protein dishevelled (Dsh) C terminal Dishevelled PF02377.13 212648.1_16126001_2 - 5.7e-59 199.0 14.9 5.7e-59 199.0 14.9 2.5 2 1 0 2 2 2 1 Dishevelled specific domain DIX PF00778.15 212648.1_16126001_2 - 1.2e-32 111.5 0.6 3.1e-32 110.1 0.4 1.8 2 0 0 2 2 2 1 DIX domain PDZ PF00595.22 212648.1_16126001_2 - 1.2e-18 67.1 0.3 2e-18 66.4 0.3 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) DEP PF00610.19 212648.1_16126001_2 - 1e-16 60.6 0.1 4.1e-16 58.7 0.1 2.0 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ_2 PF13180.4 212648.1_16126001_2 - 0.0065 16.6 0.1 0.017 15.3 0.1 1.7 1 0 0 1 1 1 1 PDZ domain Shufflon_N PF04917.10 212648.1_16126001_2 - 0.036 13.4 0.1 0.063 12.6 0.1 1.3 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region Auxin_canalis PF05703.9 212648.1_16126001_2 - 0.19 11.5 0.3 0.34 10.7 0.3 1.3 1 0 0 1 1 1 0 Auxin canalisation U-box PF04564.13 199674.2_16125001_3 - 8.8e-31 105.8 0.1 1.9e-30 104.7 0.0 1.6 2 0 0 2 2 1 1 U-box domain TPR_1 PF00515.26 199674.2_16125001_3 - 6.2e-17 60.5 10.1 3.4e-08 32.8 1.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 199674.2_16125001_3 - 5.6e-16 57.2 9.1 3.6e-05 23.4 0.7 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.5 199674.2_16125001_3 - 1e-12 47.9 5.5 2.1e-12 46.9 5.5 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.4 199674.2_16125001_3 - 2e-11 43.2 3.9 5.7e-05 22.6 0.0 3.3 1 1 2 3 3 3 2 TPR repeat TPR_8 PF13181.4 199674.2_16125001_3 - 4.6e-10 38.8 5.8 0.00044 20.1 0.7 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.4 199674.2_16125001_3 - 3.1e-09 36.8 12.3 8.3e-08 32.3 4.4 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.4 199674.2_16125001_3 - 5.8e-09 36.4 0.9 7.5e-06 26.4 0.2 2.6 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_17 PF13431.4 199674.2_16125001_3 - 6.6e-07 29.2 5.7 0.00092 19.3 0.6 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.4 199674.2_16125001_3 - 2.5e-06 27.0 5.8 0.31 11.0 0.5 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 199674.2_16125001_3 - 2.6e-06 27.7 1.4 4e-05 23.9 1.3 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.4 199674.2_16125001_3 - 8e-06 25.8 1.7 0.0012 18.9 0.6 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.4 199674.2_16125001_3 - 0.00022 21.5 2.5 6 7.6 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.4 199674.2_16125001_3 - 0.0011 19.4 0.1 2.2 9.2 0.0 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.4 199674.2_16125001_3 - 0.011 15.5 4.2 0.36 10.6 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3808 PF10300.7 199674.2_16125001_3 - 0.035 12.7 1.5 0.054 12.1 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) Paf67 PF10255.7 199674.2_16125001_3 - 0.043 12.7 2.0 0.052 12.4 1.1 1.5 1 1 0 1 1 1 0 RNA polymerase I-associated factor PAF67 SRP_TPR_like PF17004.3 199674.2_16125001_3 - 0.056 13.3 2.3 0.13 12.2 2.3 1.5 1 0 0 1 1 1 0 Putative TPR-like repeat MIT PF04212.16 199674.2_16125001_3 - 2.8 8.0 5.8 11 6.1 0.1 3.4 4 0 0 4 4 3 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.7 199674.2_16125001_3 - 3.2 7.2 5.9 1.1 8.6 0.3 2.6 3 0 0 3 3 3 0 SHNi-TPR zf-C3HC4_3 PF13920.4 212896.1_16124001_3 - 5.7e-12 45.2 12.3 5.7e-12 45.2 12.3 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) FYVE_2 PF02318.14 212896.1_16124001_3 - 3.4e-06 27.1 6.2 3.4e-06 27.1 6.2 2.7 2 0 0 2 2 2 1 FYVE-type zinc finger Armet PF10208.7 212896.1_16124001_3 - 2e-05 24.4 7.2 0.019 14.7 0.7 2.8 2 1 1 3 3 3 2 Degradation arginine-rich protein for mis-folding Prok-RING_4 PF14447.4 212896.1_16124001_3 - 0.00053 19.7 12.0 0.00053 19.7 12.0 2.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 SAP PF02037.25 212896.1_16124001_3 - 0.00074 19.1 0.1 0.16 11.6 0.0 2.7 2 0 0 2 2 2 1 SAP domain FYVE PF01363.19 212896.1_16124001_3 - 0.0041 17.1 13.4 0.0041 17.1 13.4 3.2 2 2 0 2 2 2 1 FYVE zinc finger HeH PF12949.5 212896.1_16124001_3 - 0.0058 16.2 0.3 0.5 10.0 0.1 2.6 2 0 0 2 2 2 1 HeH/LEM domain zf-RING_5 PF14634.4 212896.1_16124001_3 - 0.0073 16.1 12.2 0.0073 16.1 12.2 2.8 2 0 0 2 2 2 1 zinc-RING finger domain Ish1 PF10281.7 212896.1_16124001_3 - 0.047 13.9 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein DIM1 PF02966.14 001290146.1_16122001_1 - 5.5e-52 174.9 0.0 7.7e-52 174.4 0.0 1.2 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.18 001290146.1_16122001_1 - 0.00039 20.2 0.0 0.00061 19.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Frizzled PF01534.15 001305469.1_16129001_3 - 5.6e-122 406.7 23.5 1e-121 405.8 23.5 1.5 1 1 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.20 001305469.1_16129001_3 - 6.1e-28 97.6 1.7 1.4e-27 96.4 1.7 1.6 1 0 0 1 1 1 1 Fz domain ANF_receptor PF01094.26 001302228.1_16126001_2 - 9.2e-101 337.3 0.0 1.2e-100 336.9 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 001302228.1_16126001_2 - 5.4e-58 196.4 15.7 8.2e-58 195.8 15.7 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 001302228.1_16126001_2 - 4.1e-12 45.8 13.1 7.7e-12 44.9 13.1 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001302228.1_16126001_2 - 1.1e-05 25.1 0.0 2.9e-05 23.8 0.0 1.5 2 0 0 2 2 2 1 Periplasmic binding protein I-set PF07679.14 001039832.1_16123001_1 - 1e-40 137.5 2.8 3.9e-18 65.2 0.0 4.0 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 001039832.1_16123001_1 - 2.2e-37 127.4 3.1 8.1e-16 58.3 0.2 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001039832.1_16123001_1 - 3.8e-29 100.7 3.3 3.5e-12 46.4 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 001039832.1_16123001_1 - 1.2e-25 89.4 1.8 1.9e-12 47.1 0.1 4.0 3 2 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001039832.1_16123001_1 - 1e-13 51.3 5.2 0.00041 20.4 0.2 5.5 3 3 2 5 5 5 4 Immunoglobulin V-set domain Izumo-Ig PF16706.3 001039832.1_16123001_1 - 6.8e-08 32.3 0.1 0.022 14.6 0.0 3.8 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain Ig_5 PF16681.3 001039832.1_16123001_1 - 3e-07 30.6 0.0 0.52 10.6 0.1 3.9 2 2 1 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 001039832.1_16123001_1 - 1.7e-06 27.9 0.1 0.0098 15.8 0.0 2.8 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain V-set_CD47 PF08204.9 001039832.1_16123001_1 - 0.002 18.0 0.8 1.6 8.6 0.1 2.8 3 0 0 3 3 3 2 CD47 immunoglobulin-like domain Ig_4 PF16680.3 001039832.1_16123001_1 - 0.0034 17.6 0.2 21 5.4 0.0 3.8 4 1 0 4 4 4 0 T-cell surface glycoprotein CD3 delta chain Gp5_C PF06715.10 001039832.1_16123001_1 - 0.073 13.1 1.4 0.12 12.5 0.2 2.1 2 0 0 2 2 2 0 Gp5 C-terminal repeat (3 copies) Cu2_monoox_C PF03712.13 001039832.1_16123001_1 - 2.6 7.4 6.5 22 4.4 0.0 3.5 4 0 0 4 4 4 0 Copper type II ascorbate-dependent monooxygenase, C-terminal domain S_100 PF01023.17 213003.1_16122001_1 - 8.6e-22 76.5 0.3 1.6e-21 75.6 0.3 1.5 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.30 213003.1_16122001_1 - 1.9e-08 33.1 0.5 7.9e-07 28.1 0.2 2.7 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.4 213003.1_16122001_1 - 2.3e-07 31.0 0.1 4.2e-07 30.2 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 213003.1_16122001_1 - 5.8e-05 22.3 1.4 0.00042 19.6 0.3 2.3 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 213003.1_16122001_1 - 0.00018 21.1 0.1 0.00045 19.8 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 213003.1_16122001_1 - 0.00047 19.8 0.1 0.12 12.3 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain C1-set PF07654.13 213126.2_16128001_1 - 2e-19 69.7 0.0 3.4e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 213126.2_16128001_1 - 0.055 13.9 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain 7tm_1 PF00001.19 001166333.1_16123001_1 - 2.7e-25 89.0 7.5 3.3e-25 88.7 7.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001166333.1_16123001_1 - 3.2e-07 29.8 5.6 5.3e-07 29.1 5.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx TMEM65 PF10507.7 001166333.1_16123001_1 - 0.013 15.4 0.1 0.041 13.8 0.1 1.9 1 0 0 1 1 1 0 Transmembrane protein 65 Serpentine_r_xa PF03383.13 001166333.1_16123001_1 - 0.031 14.1 0.6 0.031 14.1 0.6 1.8 2 0 0 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa 7TM_GPCR_Srw PF10324.7 001166333.1_16123001_1 - 0.27 10.4 6.0 3.7 6.6 6.1 2.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw Reeler PF02014.14 001328267.1_16124001_3 - 3.2e-20 73.0 0.1 3.2e-20 73.0 0.1 2.2 2 0 0 2 2 2 1 Reeler domain DUF3332 PF11810.6 001328267.1_16124001_3 - 0.055 13.0 0.3 0.089 12.3 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) CD20 PF04103.13 001017670.1_16122001_3 - 1.6e-21 76.9 19.0 1.3e-19 70.7 19.0 2.2 1 1 0 1 1 1 1 CD20-like family FIST_C PF10442.7 001030106.1_16124001_1 - 6.6e-11 42.2 0.1 1.2e-10 41.3 0.1 1.4 1 0 0 1 1 1 1 FIST C domain F-box PF00646.31 001030106.1_16124001_1 - 2.4e-06 27.1 0.3 5.5e-06 26.0 0.3 1.5 1 0 0 1 1 1 1 F-box domain FIST PF08495.8 001030106.1_16124001_1 - 3.2e-06 27.1 0.0 0.00021 21.2 0.0 2.2 2 0 0 2 2 2 1 FIST N domain F-box-like PF12937.5 001030106.1_16124001_1 - 7.8e-05 22.3 0.4 0.00018 21.2 0.4 1.6 1 0 0 1 1 1 1 F-box-like WW_FCH_linker PF16623.3 001278819.1_16124001_2 - 1.6e-20 73.5 0.4 4.6e-20 72.0 0.4 1.9 1 0 0 1 1 1 1 Unstructured linker region between on GAS7 protein FCH PF00611.21 001278819.1_16124001_2 - 3.1e-14 52.8 1.8 3.1e-14 52.8 1.8 2.1 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Scaffolding_pro PF11418.6 001278819.1_16124001_2 - 0.27 11.7 5.6 0.11 12.9 1.1 2.5 3 0 0 3 3 3 0 Phi29 scaffolding protein DUF1664 PF07889.10 001278819.1_16124001_2 - 0.46 10.4 4.9 0.73 9.7 3.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4455 PF14643.4 001278819.1_16124001_2 - 0.51 8.9 22.6 0.026 13.1 2.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4455) TPR_MLP1_2 PF07926.10 001278819.1_16124001_2 - 0.56 10.1 17.7 0.26 11.2 3.9 3.0 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein DUF2680 PF10925.6 001278819.1_16124001_2 - 1 9.3 5.6 0.2 11.6 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) Metallophos PF00149.26 001328556.1_16125001_3 - 2.6e-15 57.3 1.6 3.8e-15 56.8 1.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TLD PF07534.14 001077169.2_16125001_1 - 2.3e-15 56.9 0.3 5e-15 55.8 0.3 1.6 1 0 0 1 1 1 1 TLD MMR_HSR1 PF01926.21 001077169.2_16125001_1 - 3e-05 23.9 0.0 7.3e-05 22.7 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001077169.2_16125001_1 - 0.00094 19.0 1.2 0.16 11.7 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_29 PF13555.4 001077169.2_16125001_1 - 0.0064 16.0 0.1 0.014 15.0 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Arf PF00025.19 001077169.2_16125001_1 - 0.017 14.4 0.2 0.59 9.4 0.3 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family ATP_bind_1 PF03029.15 001077169.2_16125001_1 - 0.022 14.4 0.7 3.7 7.1 0.1 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein IIGP PF05049.11 001077169.2_16125001_1 - 0.059 12.3 0.0 0.097 11.6 0.0 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Septin PF00735.16 001077169.2_16125001_1 - 0.061 12.4 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Septin AIG1 PF04548.14 001077169.2_16125001_1 - 0.12 11.6 0.1 0.26 10.5 0.1 1.5 1 0 0 1 1 1 0 AIG1 family Orai-1 PF07856.10 001166447.1_16122001_3 - 9.9e-70 233.7 7.2 1.3e-69 233.3 7.2 1.1 1 0 0 1 1 1 1 Mediator of CRAC channel activity Globin PF00042.20 001013461.1_16122001_2 - 2.8e-23 82.4 0.0 4.3e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 Globin Fibrinogen_C PF00147.16 131818.3_16125001_3 - 2.5e-63 213.7 1.0 3.5e-63 213.2 1.0 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain IncA PF04156.12 131818.3_16125001_3 - 0.0025 17.5 6.8 0.0047 16.6 6.8 1.5 1 0 0 1 1 1 1 IncA protein CALCOCO1 PF07888.9 131818.3_16125001_3 - 0.11 10.9 6.7 0.16 10.4 6.7 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF1664 PF07889.10 131818.3_16125001_3 - 0.4 10.5 11.3 0.13 12.1 3.0 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) LRRFIP PF09738.7 131818.3_16125001_3 - 0.52 9.6 14.5 0.86 8.9 2.8 2.1 1 1 1 2 2 2 0 LRRFIP family FliJ PF02050.14 131818.3_16125001_3 - 0.66 10.1 5.0 1.3 9.1 4.6 1.7 1 1 0 1 1 1 0 Flagellar FliJ protein USP8_interact PF08941.8 131818.3_16125001_3 - 0.7 9.5 5.1 7.1 6.3 0.4 2.2 2 0 0 2 2 2 0 USP8 interacting DUF342 PF03961.11 131818.3_16125001_3 - 1.6 7.1 9.1 2.7 6.4 9.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF16 PF01519.14 131818.3_16125001_3 - 1.7 9.1 18.7 11 6.4 6.2 3.0 2 1 1 3 3 3 0 Protein of unknown function DUF16 SlyX PF04102.10 131818.3_16125001_3 - 1.8 9.1 6.2 2.3 8.8 2.3 2.6 1 1 1 2 2 2 0 SlyX Nup54 PF13874.4 131818.3_16125001_3 - 4.7 7.2 8.1 15 5.5 7.8 2.0 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Baculo_PEP_C PF04513.10 131818.3_16125001_3 - 4.8 7.1 12.5 2.6 7.9 3.6 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.10 131818.3_16125001_3 - 5.2 7.5 10.2 4.5 7.7 5.0 2.9 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.8 131818.3_16125001_3 - 6 6.9 16.9 11 6.0 6.6 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.13 131818.3_16125001_3 - 7.3 5.9 7.6 18 4.7 7.6 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit Metallophos PF00149.26 001080043.1_16126001_3 - 1.1e-11 45.6 0.0 1.6e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.5 001080043.1_16126001_3 - 6.8e-06 26.3 0.0 1.2e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain GTP-bdg_N PF13167.4 001080043.1_16126001_3 - 0.04 14.4 0.0 0.082 13.4 0.0 1.4 1 0 0 1 1 1 0 GTP-binding GTPase N-terminal PsaL PF02605.13 001080043.1_16126001_3 - 0.086 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Photosystem I reaction centre subunit XI PIP49_C PF12260.6 001007436.1_16124001_2 - 1.1e-49 168.5 0.0 1.5e-49 168.0 0.0 1.2 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 IMD PF08397.9 001017830.1_16126001_2 - 3.2e-58 196.6 6.2 4.1e-58 196.2 6.2 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain SH3_9 PF14604.4 001017830.1_16126001_2 - 1.8e-11 43.6 0.0 3e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001017830.1_16126001_2 - 1.7e-08 33.9 0.0 3e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001017830.1_16126001_2 - 4.7e-08 32.4 0.1 8.4e-08 31.6 0.1 1.4 1 0 0 1 1 1 1 SH3 domain BAR_3 PF16746.3 001017830.1_16126001_2 - 0.025 14.1 8.8 0.052 13.1 8.8 1.4 1 0 0 1 1 1 0 BAR domain of APPL family Homez PF11569.6 001017830.1_16126001_2 - 0.14 11.5 0.2 0.28 10.5 0.2 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez OmpH PF03938.12 001017830.1_16126001_2 - 0.74 9.7 4.0 1.2 9.0 4.0 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DIM1 PF02966.14 001037123.3_16122001_1 - 4.5e-52 175.2 0.0 5.8e-52 174.8 0.0 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.18 001037123.3_16122001_1 - 0.00034 20.4 0.0 0.00048 19.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DUF2787 PF10980.6 001037123.3_16122001_2 - 0.1 12.7 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2787) Gln-synt_C PF00120.22 001075114.2_16124001_1 - 7.3e-17 61.2 0.0 5.1e-13 48.6 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.17 001075114.2_16124001_1 - 7.1e-14 51.2 0.0 1.2e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain TIG PF01833.22 001130399.1_16129001_1 - 3.4e-141 459.5 114.6 1.5e-15 56.9 4.2 16.0 14 1 1 15 15 15 14 IPT/TIG domain G8 PF10162.7 001130399.1_16129001_1 - 1.8e-68 228.1 0.6 8e-36 122.7 0.2 2.7 2 0 0 2 2 2 2 G8 domain Beta_helix PF13229.4 001130399.1_16129001_1 - 4.6e-15 55.7 24.4 5.5e-07 29.4 0.8 5.7 4 1 1 5 5 5 3 Right handed beta helix region PA14 PF07691.10 001130399.1_16129001_1 - 0.0015 18.2 0.1 0.0044 16.7 0.1 1.8 1 0 0 1 1 1 1 PA14 domain TcfC PF16967.3 001130399.1_16129001_1 - 0.0077 15.6 0.7 1.4 8.4 0.0 3.7 4 0 0 4 4 4 1 Fimbrial, FimD or usher-like NosD PF05048.11 001130399.1_16129001_1 - 0.045 12.9 14.0 0.6 9.2 0.0 4.3 4 1 1 5 5 5 0 Periplasmic copper-binding protein (NosD) polyprenyl_synt PF00348.15 001291761.1_16129001_1 - 1.6e-53 181.3 0.0 2.2e-53 180.8 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase AMP-binding PF00501.26 001045419.2_16126001_3 - 8e-99 330.9 0.0 9.8e-99 330.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001045419.2_16126001_3 - 9.8e-19 68.0 0.1 2.2e-18 66.9 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CKS PF01111.17 001003593.3_16122001_3 - 1.2e-37 127.9 1.1 1.8e-37 127.3 1.1 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit 2-oxoacid_dh PF00198.21 001013515.1_16125001_3 - 3.8e-77 258.7 0.0 5.5e-77 258.2 0.0 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.20 001013515.1_16125001_3 - 1.1e-18 66.7 0.3 1.8e-18 66.0 0.3 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.15 001013515.1_16125001_3 - 8.6e-16 57.9 0.1 2.2e-15 56.6 0.1 1.7 1 0 0 1 1 1 1 e3 binding domain Ribosomal_L16 PF00252.16 001007764.1_16123001_3 - 2.9e-29 101.6 0.0 2.9e-29 101.6 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L16p/L10e AP3D1 PF06375.9 001007764.1_16123001_3 - 0.26 11.4 10.4 0.57 10.3 10.4 1.6 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Ofd1_CTDD PF10637.7 199689.3_16124001_2 - 5.4e-42 143.8 0.4 9.1e-39 133.2 0.1 2.5 2 1 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.4 199689.3_16124001_2 - 5.7e-33 113.3 0.1 9.5e-29 99.8 0.0 2.4 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.4 199689.3_16124001_2 - 2.2e-14 54.0 0.0 3.8e-13 50.0 0.0 2.4 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Aldo_ket_red PF00248.19 001291346.1_16123001_2 - 4e-54 183.6 0.0 2.4e-52 177.8 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family 7tm_4 PF13853.4 001031543.1_23522001_1 - 1.3e-48 166.0 20.3 1.7e-48 165.7 20.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001031543.1_23522001_1 - 1.5e-18 66.9 22.0 3.9e-18 65.5 22.0 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CytB6-F_Fe-S PF08802.8 001031543.1_23522001_1 - 0.28 11.1 1.6 4.3 7.3 0.1 2.8 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit DEAD PF00270.27 199882.1_16127001_3 - 1.4e-53 181.1 0.0 7.5e-53 178.8 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 199882.1_16127001_3 - 5.6e-30 103.8 0.0 2.1e-29 102.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain GRAM PF02893.18 001020544.2_16128001_2 - 1.7e-11 43.8 0.0 2.9e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 GRAM domain zf-C2H2 PF00096.24 213637.1_16126001_1 - 1e-23 82.3 33.0 4.9e-06 26.6 0.5 6.0 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 213637.1_16126001_1 - 1.4e-16 60.0 24.6 2.7e-07 30.6 0.3 6.0 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_6 PF13912.4 213637.1_16126001_1 - 2.7e-10 39.8 30.3 0.041 13.7 3.2 5.8 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_4 PF13894.4 213637.1_16126001_1 - 4.7e-10 39.3 52.8 0.00042 20.8 0.5 7.0 7 0 0 7 7 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 213637.1_16126001_1 - 2.2e-08 34.1 18.4 0.045 14.0 0.1 5.6 4 1 1 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 213637.1_16126001_1 - 0.00013 22.1 28.7 0.1 12.9 1.4 5.7 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.3 213637.1_16126001_1 - 0.055 14.1 13.0 0.34 11.5 0.8 3.1 2 1 0 2 2 2 0 zinc-ribbon family HypA PF01155.17 213637.1_16126001_1 - 0.11 12.4 11.8 0.18 11.7 0.7 3.2 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.8 213637.1_16126001_1 - 0.61 10.1 11.9 7.7 6.6 0.6 3.9 2 2 0 3 3 3 0 Zinc ribbon domain Rpr2 PF04032.14 213637.1_16126001_1 - 0.63 10.3 10.8 6.6 7.0 0.5 3.0 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain C1_4 PF07975.10 213637.1_16126001_1 - 0.77 9.9 14.9 1.4 9.1 2.5 2.9 2 1 0 2 2 2 0 TFIIH C1-like domain zinc_ribbon_9 PF14369.4 213637.1_16126001_1 - 3.2 8.0 6.8 11 6.2 0.3 4.2 4 1 0 4 4 4 0 zinc-ribbon Zn_ribbon_recom PF13408.4 213637.1_16126001_1 - 3.4 8.1 11.1 3.5 8.1 1.8 2.8 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-C2H2_2 PF12756.5 213637.1_16126001_1 - 3.9 7.7 21.3 19 5.5 5.9 4.3 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-LYAR PF08790.9 213637.1_16126001_1 - 5.9 6.8 10.1 21 5.0 0.1 4.2 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger Ig_3 PF13927.4 001045246.1_16123001_1 - 1.9e-30 105.2 0.9 4.9e-09 36.5 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001045246.1_16123001_1 - 1.2e-24 86.3 0.0 9.1e-08 32.2 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 001045246.1_16123001_1 - 7e-21 74.0 0.0 3.8e-08 33.2 0.1 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain C2-set_2 PF08205.10 001045246.1_16123001_1 - 4e-18 65.1 0.1 4e-16 58.7 0.0 2.6 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 001045246.1_16123001_1 - 3.8e-17 62.3 1.1 8.4e-08 32.2 0.1 3.8 3 1 1 4 4 4 3 Immunoglobulin V-set domain ig PF00047.23 001045246.1_16123001_1 - 2.3e-14 53.2 1.3 7.8e-05 22.6 0.0 3.9 3 2 0 3 3 3 3 Immunoglobulin domain C1-set PF07654.13 001045246.1_16123001_1 - 7.6e-07 29.4 0.1 1.6e-05 25.1 0.0 2.8 3 1 0 3 3 3 1 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 001045246.1_16123001_1 - 0.0012 18.7 0.0 0.11 12.5 0.0 2.4 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain Uricase PF01014.16 001045246.1_16123001_1 - 0.0092 16.3 0.0 0.018 15.4 0.0 1.4 1 0 0 1 1 1 1 Uricase Ig_4 PF16680.3 001045246.1_16123001_1 - 0.024 14.9 0.1 38 4.6 0.0 3.6 3 1 1 4 4 4 0 T-cell surface glycoprotein CD3 delta chain Syndecan PF01034.18 001045246.1_16123001_1 - 0.048 13.5 0.1 0.14 11.9 0.1 1.7 1 0 0 1 1 1 0 Syndecan domain VWD PF00094.23 001281989.1_16129001_1 - 2.3e-99 330.1 26.3 1.5e-36 125.9 0.4 6.0 7 0 0 7 7 7 4 von Willebrand factor type D domain VWA PF00092.26 001281989.1_16129001_1 - 1.3e-56 191.5 3.3 3.8e-22 79.3 0.3 3.2 3 0 0 3 3 3 3 von Willebrand factor type A domain C8 PF08742.9 001281989.1_16129001_1 - 1.3e-49 166.4 66.5 2.4e-17 63.0 9.7 10.0 10 1 0 10 10 10 4 C8 domain TIL PF01826.15 001281989.1_16129001_1 - 1.7e-27 95.3 109.6 1e-11 44.8 14.3 21.6 16 5 6 22 22 22 5 Trypsin Inhibitor like cysteine rich domain VWA_2 PF13519.4 001281989.1_16129001_1 - 4.9e-15 56.0 6.4 1.7e-07 31.8 0.1 3.5 3 0 0 3 3 3 3 von Willebrand factor type A domain VWC PF00093.16 001281989.1_16129001_1 - 1.9e-05 24.7 52.9 0.00025 21.2 13.1 21.2 16 4 2 18 18 18 6 von Willebrand factor type C domain Pacifastin_I PF05375.11 001281989.1_16129001_1 - 5.1e-05 22.8 7.0 5.1e-05 22.8 7.0 13.7 14 0 0 14 14 14 3 Pacifastin inhibitor (LCMII) Vault PF01505.16 001281989.1_16129001_1 - 0.19 11.9 0.1 2 8.6 0.0 2.6 2 0 0 2 2 2 0 Major Vault Protein repeat HABP4_PAI-RBP1 PF04774.13 214714.1_16125001_2 - 6.1e-28 97.9 14.7 6.1e-28 97.9 14.7 3.3 3 1 0 3 3 3 1 Hyaluronan / mRNA binding family IHABP4_N PF16174.3 214714.1_16125001_2 - 1.3e-27 97.3 28.4 1.3e-27 97.3 28.4 4.5 3 2 0 3 3 3 1 Intracellular hyaluronan-binding protein 4 N-terminal Myosin_head PF00063.19 001324479.1_16129001_3 - 4e-288 957.1 0.8 4e-288 957.1 0.8 2.6 3 0 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 001324479.1_16129001_3 - 4.2e-158 528.1 265.9 6.1e-158 527.5 265.9 1.2 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 001324479.1_16129001_3 - 4.6e-13 48.6 4.6 1.1e-12 47.5 4.6 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Filament PF00038.19 001324479.1_16129001_3 - 0.002 17.6 17.2 0.002 17.6 17.2 7.8 1 1 5 6 6 6 3 Intermediate filament protein Reo_sigmaC PF04582.10 001324479.1_16129001_3 - 0.0023 17.2 86.7 0.019 14.2 3.6 9.4 1 1 10 11 11 11 7 Reovirus sigma C capsid protein AAA_22 PF13401.4 001324479.1_16129001_3 - 0.084 13.0 0.0 0.084 13.0 0.0 5.7 4 2 2 6 6 6 0 AAA domain AAA_16 PF13191.4 001324479.1_16129001_3 - 0.44 10.8 0.0 0.44 10.8 0.0 5.7 4 3 0 4 4 4 0 AAA ATPase domain Glyco_hydro_1 PF00232.16 001020693.1_16124001_2 - 9.6e-158 525.2 0.0 1.2e-157 524.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Cellulase PF00150.16 001020693.1_16124001_2 - 0.0032 16.8 0.0 0.0092 15.3 0.0 1.7 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Ifi-6-16 PF06140.11 001327855.1_16122001_2 - 5.9e-21 74.0 33.8 5.9e-21 74.0 33.8 2.2 1 1 1 2 2 2 1 Interferon-induced 6-16 family Reticulon PF02453.15 001328271.1_16128001_1 - 1.3e-45 155.1 8.8 2.4e-45 154.1 8.8 1.5 1 0 0 1 1 1 1 Reticulon Itfg2 PF15907.3 001017908.2_16124001_3 - 1e-160 534.3 0.1 5.2e-159 528.7 0.0 2.0 1 1 1 2 2 2 2 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_Mid PF14783.4 001017908.2_16124001_3 - 2.8e-14 53.0 0.1 0.0023 17.8 0.0 3.5 3 0 0 3 3 3 3 Ciliary BBSome complex subunit 2, middle region VCBS PF13517.4 001017908.2_16124001_3 - 1.9e-06 28.2 6.6 0.15 12.5 0.0 3.9 4 0 0 4 4 4 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.21 001017908.2_16124001_3 - 0.00025 21.0 1.8 2.4 8.3 0.1 3.8 3 0 0 3 3 3 2 FG-GAP repeat BBS1 PF14779.4 001017908.2_16124001_3 - 0.021 14.1 0.1 7.3 5.8 0.1 2.8 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 1 DUF2508 PF10704.7 001045140.1_16124001_1 - 0.05 13.7 1.1 8.5 6.5 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) MitMem_reg PF13012.4 001045140.1_16124001_1 - 0.071 13.4 0.2 1.6 9.1 0.2 2.4 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function GAS PF13851.4 001045140.1_16124001_1 - 0.073 12.3 1.5 0.11 11.8 1.0 1.5 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding PNRC PF15365.4 001104944.1_16123001_1 - 0.27 11.7 1.7 0.66 10.5 1.7 1.7 1 0 0 1 1 1 0 Proline-rich nuclear receptor coactivator Reo_sigmaC PF04582.10 001104944.1_16123001_3 - 0.14 11.4 1.8 0.22 10.8 1.0 1.4 1 1 0 1 1 1 0 Reovirus sigma C capsid protein TSGP1 PF07771.9 001104944.1_16123001_3 - 8 6.5 14.8 21 5.2 14.8 1.7 1 0 0 1 1 1 0 Tick salivary peptide group 1 Forkhead PF00250.16 001326388.1_16128001_1 - 3.6e-37 126.4 0.2 8e-37 125.3 0.2 1.6 1 0 0 1 1 1 1 Forkhead domain Ank_2 PF12796.5 001002528.1_16123001_2 - 3.5e-33 113.9 6.2 6e-15 55.5 1.2 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001002528.1_16123001_2 - 5.1e-32 109.7 15.8 1.6e-09 38.0 0.0 4.3 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 001002528.1_16123001_2 - 1.9e-27 92.1 8.2 3.6e-05 23.7 0.0 6.7 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.28 001002528.1_16123001_2 - 1e-25 88.8 15.8 0.00021 21.5 0.1 6.5 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.4 001002528.1_16123001_2 - 6.8e-24 83.4 11.7 4.7e-09 36.2 0.1 5.5 2 1 4 6 6 6 5 Ankyrin repeats (many copies) SOCS_box PF07525.14 001002528.1_16123001_2 - 2.6e-08 33.9 0.2 5.4e-08 32.9 0.2 1.5 1 0 0 1 1 1 1 SOCS box G-gamma PF00631.20 214721.2_16122001_3 - 2e-14 53.2 0.1 4.1e-14 52.2 0.0 1.5 2 0 0 2 2 2 1 GGL domain ABC_transp_aux PF09822.7 001001834.2_16125001_2 - 1e-10 41.4 0.1 1.8e-10 40.7 0.1 1.3 1 0 0 1 1 1 1 ABC-type uncharacterized transport system DDOST_48kD PF03345.12 001001834.2_16125001_2 - 0.043 12.5 0.0 0.41 9.3 0.0 2.0 1 1 0 1 1 1 0 Oligosaccharyltransferase 48 kDa subunit beta DUF4159 PF13709.4 001001834.2_16125001_2 - 0.12 11.6 0.0 0.29 10.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4159) OLF PF02191.14 001126472.1_16125001_3 - 1.5e-85 286.6 12.1 2.9e-85 285.7 12.1 1.5 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.6 001126472.1_16125001_3 - 0.00024 20.9 0.3 0.00024 20.9 0.3 2.3 1 1 1 2 2 2 1 Neurogenesis glycoprotein DUF2956 PF11169.6 001126472.1_16125001_3 - 0.0092 16.0 1.5 0.022 14.8 1.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2956) EntA_Immun PF08951.8 001126472.1_16125001_3 - 0.091 13.0 2.1 0.18 12.1 2.1 1.4 1 0 0 1 1 1 0 Enterocin A Immunity SWIM PF04434.15 001083540.1_16122001_2 - 0.00024 20.5 1.9 0.00024 20.5 1.9 2.0 3 0 0 3 3 3 1 SWIM zinc finger Peptidase_C14 PF00656.20 001136252.1_16123001_3 - 1.1e-47 163.0 0.0 1.5e-47 162.5 0.0 1.1 1 0 0 1 1 1 1 Caspase domain CARD PF00619.19 001136252.1_16123001_3 - 2.1e-06 27.5 1.7 6.2e-06 26.0 1.7 1.8 1 0 0 1 1 1 1 Caspase recruitment domain GIT1_C PF12205.6 001080188.1_16129001_3 - 5e-39 132.9 2.3 5e-39 132.9 2.3 1.8 2 0 0 2 2 2 1 G protein-coupled receptor kinase-interacting protein 1 C term ArfGap PF01412.16 001080188.1_16129001_3 - 1.8e-27 95.5 1.5 1.8e-27 95.5 1.5 2.4 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf GIT_CC PF16559.3 001080188.1_16129001_3 - 6.9e-27 93.2 6.9 1.4e-26 92.2 6.9 1.5 1 0 0 1 1 1 1 GIT coiled-coil Rho guanine nucleotide exchange factor GIT_SHD PF08518.9 001080188.1_16129001_3 - 1.7e-26 91.3 1.8 1.8e-14 52.9 0.1 2.4 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT Ank_2 PF12796.5 001080188.1_16129001_3 - 1.3e-08 35.2 0.0 2.8e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001080188.1_16129001_3 - 3.4e-07 30.3 0.0 1.2e-06 28.6 0.0 2.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.4 001080188.1_16129001_3 - 1.3e-05 25.5 0.0 0.0043 17.5 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.28 001080188.1_16129001_3 - 0.0007 19.8 0.0 0.0043 17.3 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat TTRAP PF14203.4 001080188.1_16129001_3 - 0.071 12.9 0.0 0.27 11.1 0.0 2.0 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein Ank_3 PF13606.4 001080188.1_16129001_3 - 0.13 12.8 0.0 0.99 10.1 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeat Ribosomal_S18 PF01084.18 001030114.1_16122001_1 - 4.5e-16 58.7 0.0 8.6e-16 57.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 PDZ PF00595.22 212940.2_16127001_1 - 4.3e-62 206.3 1.5 2.2e-15 56.6 0.0 4.2 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 212940.2_16127001_1 - 9.2e-17 61.0 3.3 0.0011 19.1 0.1 4.4 4 0 0 4 4 4 4 PDZ domain zf-RING_UBOX PF13445.4 212940.2_16127001_1 - 1.7e-06 27.8 8.9 6.5e-06 25.9 8.9 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 212940.2_16127001_1 - 4.2e-06 26.4 7.5 1.4e-05 24.7 7.5 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 212940.2_16127001_1 - 4.9e-06 26.1 9.8 4.9e-06 26.1 9.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 212940.2_16127001_1 - 5.7e-06 26.0 3.7 5.7e-06 26.0 3.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 212940.2_16127001_1 - 1.3e-05 25.1 8.6 3.6e-05 23.7 8.6 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 212940.2_16127001_1 - 2.1e-05 24.5 7.4 2.1e-05 24.5 7.4 2.5 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.4 212940.2_16127001_1 - 0.00015 21.5 6.3 0.00015 21.5 6.3 2.2 2 0 0 2 2 2 1 zinc-RING finger domain Tricorn_PDZ PF14685.4 212940.2_16127001_1 - 0.0022 17.8 0.4 0.95 9.4 0.1 3.3 3 0 0 3 3 3 1 Tricorn protease PDZ domain zf-rbx1 PF12678.5 212940.2_16127001_1 - 0.0028 17.8 7.5 0.0076 16.4 7.5 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain U-box PF04564.13 212940.2_16127001_1 - 0.037 14.1 0.1 0.08 13.0 0.1 1.6 1 0 0 1 1 1 0 U-box domain BNIP3 PF06553.10 205570.2_16125001_2 - 7.7e-59 198.5 0.9 1e-58 198.1 0.9 1.1 1 0 0 1 1 1 1 BNIP3 Ribosomal_L7Ae PF01248.24 213031.3_16123001_3 - 5.3e-13 48.4 0.1 1.1e-12 47.4 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Na_H_Exchanger PF00999.19 001030077.2_16129001_1 - 3.7e-92 308.9 35.8 1e-91 307.4 35.8 1.6 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family P2X_receptor PF00864.17 198984.2_16124001_1 - 4e-148 493.2 7.0 5.2e-148 492.9 7.0 1.1 1 0 0 1 1 1 1 ATP P2X receptor CDtoxinA PF03498.12 198984.2_16124001_1 - 0.0074 15.7 0.3 0.022 14.2 0.3 1.8 1 0 0 1 1 1 1 Cytolethal distending toxin A/C domain BAR PF03114.16 001123044.1_16129001_1 - 2.2e-22 79.7 16.0 2.2e-22 79.7 16.0 1.8 2 0 0 2 2 2 1 BAR domain Vps5 PF09325.8 001123044.1_16129001_1 - 8.7e-07 28.6 10.7 8.7e-07 28.6 10.7 1.7 2 0 0 2 2 2 1 Vps5 C terminal like BAR_3 PF16746.3 001123044.1_16129001_1 - 4.8e-05 23.0 15.9 7.1e-05 22.5 15.9 1.1 1 0 0 1 1 1 1 BAR domain of APPL family DUF4743 PF15916.3 001123044.1_16129001_1 - 0.096 12.5 0.2 0.17 11.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4743) LTXXQ PF07813.10 001123044.1_16129001_1 - 7.2 7.3 9.0 4.3 8.0 0.5 2.4 2 0 0 2 2 2 0 LTXXQ motif family protein ETRAMP PF09716.8 001123044.1_16129001_3 - 9.8 6.2 13.1 31 4.6 13.1 1.9 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) PTN_MK_N PF05196.11 131070.2_16124001_2 - 3.8e-27 94.1 14.0 3.8e-27 94.1 14.0 2.2 3 0 0 3 3 3 1 PTN/MK heparin-binding protein family, N-terminal domain PTN_MK_C PF01091.16 131070.2_16124001_2 - 1.6e-26 92.3 9.2 1.6e-26 92.3 9.2 2.5 2 0 0 2 2 2 1 PTN/MK heparin-binding protein family, C-terminal domain V-set PF07686.15 001013328.1_16123001_3 - 8.9e-07 28.9 0.0 2.5e-06 27.5 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 001013328.1_16123001_3 - 4.4e-06 26.5 2.5 1.5e-05 24.8 0.6 2.5 2 1 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.23 001013328.1_16123001_3 - 6.8e-06 26.0 0.5 4.5e-05 23.4 0.0 2.5 2 1 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.4 001013328.1_16123001_3 - 8e-06 26.2 0.6 3.2e-05 24.3 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001013328.1_16123001_3 - 0.0059 16.8 1.1 1.8 8.9 0.0 3.1 2 1 0 3 3 3 1 Immunoglobulin domain SOAR PF16533.3 001044799.1_16126001_3 - 1.5e-42 143.5 1.5 1.5e-42 143.5 1.5 2.9 2 1 0 2 2 2 1 STIM1 Orai1-activating region SAM_2 PF07647.15 001044799.1_16126001_3 - 0.00017 21.5 1.3 0.00032 20.6 0.1 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DUF4446 PF14584.4 001044799.1_16126001_3 - 0.69 9.7 5.3 0.24 11.2 1.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) APG6 PF04111.10 001044799.1_16126001_3 - 2.6 7.2 21.9 4.9 6.3 21.9 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Stathmin PF00836.17 001044799.1_16126001_3 - 5.2 6.9 23.8 0.099 12.5 13.9 2.7 2 1 1 3 3 3 0 Stathmin family AAA_23 PF13476.4 001044799.1_16126001_3 - 5.4 7.3 21.0 96 3.3 16.5 3.3 2 1 0 2 2 2 0 AAA domain TMPIT PF07851.11 001044799.1_16126001_3 - 7.3 5.6 10.9 12 4.8 10.9 1.4 1 0 0 1 1 1 0 TMPIT-like protein Phosphodiest PF01663.20 200603.1_16127001_2 - 1.3e-79 268.3 2.7 1.3e-77 261.7 2.7 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Somatomedin_B PF01033.15 200603.1_16127001_2 - 4.3e-16 58.9 42.9 4.5e-08 33.2 15.0 3.2 2 0 0 2 2 2 2 Somatomedin B domain Endonuclease_NS PF01223.21 200603.1_16127001_2 - 2.8e-09 37.0 0.1 4.4e-09 36.3 0.1 1.3 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Sulfatase PF00884.21 200603.1_16127001_2 - 5.8e-05 22.5 0.0 0.21 10.8 0.0 2.2 2 0 0 2 2 2 2 Sulfatase Isy1 PF06246.10 001145709.1_16122001_3 - 0.0004 19.9 0.0 0.0006 19.3 0.0 1.2 1 0 0 1 1 1 1 Isy1-like splicing family Pox_A_type_inc PF04508.10 001145709.1_16122001_3 - 0.038 13.7 0.1 0.11 12.3 0.1 1.8 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat DUF1075 PF06388.9 001089343.1_16122001_2 - 5.9e-57 191.5 0.2 8.1e-57 191.0 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1075) PTH2 PF01981.14 001326571.1_16125001_2 - 1.2e-25 89.9 0.5 1.9e-25 89.2 0.5 1.3 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 UBA PF00627.29 001326571.1_16125001_2 - 0.042 13.6 0.1 0.084 12.7 0.1 1.4 1 0 0 1 1 1 0 UBA/TS-N domain DAGK_cat PF00781.22 001105586.1_16124001_1 - 1.2e-16 60.3 0.1 2.3e-16 59.4 0.1 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DAGK_cat PF00781.22 001105586.1_16124001_2 - 0.043 13.3 0.0 0.069 12.6 0.0 1.3 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain EF-hand_1 PF00036.30 001005962.2_16122001_2 - 1.9e-27 92.6 14.8 5.9e-09 34.7 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.4 001005962.2_16122001_2 - 2.5e-24 82.9 6.1 3.4e-08 32.7 0.1 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.4 001005962.2_16122001_2 - 8.2e-24 83.7 6.8 5.2e-14 52.3 0.7 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 001005962.2_16122001_2 - 2.3e-19 67.8 13.3 2.3e-06 26.7 1.2 4.1 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.4 001005962.2_16122001_2 - 6.5e-19 67.3 11.0 4.9e-12 45.3 0.4 3.9 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.4 001005962.2_16122001_2 - 3.5e-07 30.3 0.1 0.006 16.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.7 001005962.2_16122001_2 - 0.0023 18.1 0.1 0.11 12.7 0.0 2.3 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DIMCO_N PF16844.3 001005962.2_16122001_2 - 0.036 14.3 0.1 0.084 13.1 0.1 1.6 1 0 0 1 1 1 0 Dinitrogenase iron-molybdenum cofactor, N-terminal TerB PF05099.11 001005962.2_16122001_2 - 0.054 13.3 0.0 6 6.7 0.0 2.4 2 0 0 2 2 2 0 Tellurite resistance protein TerB Caleosin PF05042.11 001005962.2_16122001_2 - 0.077 12.8 0.0 2.9 7.7 0.0 2.5 2 1 0 2 2 2 0 Caleosin related protein EF-hand_4 PF12763.5 001005962.2_16122001_2 - 0.078 12.8 1.8 0.44 10.4 0.1 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.9 001005962.2_16122001_2 - 0.1 13.4 0.0 5.7 7.7 0.0 2.2 1 1 1 2 2 2 0 EF-hand domain Dockerin_1 PF00404.16 001005962.2_16122001_2 - 0.46 10.3 5.9 4 7.4 1.4 2.7 2 0 0 2 2 2 0 Dockerin type I repeat adh_short PF00106.23 001100048.1_16124001_2 - 2e-44 151.3 0.2 2.8e-44 150.8 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001100048.1_16124001_2 - 7.6e-37 127.0 1.3 1e-36 126.6 1.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001100048.1_16124001_2 - 6.3e-08 32.6 0.3 1e-07 31.9 0.3 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 001100048.1_16124001_2 - 0.00052 19.4 0.2 0.0012 18.3 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.15 001100048.1_16124001_2 - 0.014 15.8 0.0 0.035 14.5 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_10 PF13460.4 001100048.1_16124001_2 - 0.014 15.2 0.1 0.023 14.5 0.1 1.4 1 1 0 1 1 1 0 NAD(P)H-binding Shikimate_DH PF01488.18 001100048.1_16124001_2 - 0.12 12.3 0.1 0.23 11.4 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NmrA PF05368.11 001100048.1_16124001_2 - 0.14 11.6 0.0 0.35 10.3 0.0 1.6 2 0 0 2 2 2 0 NmrA-like family FSH1 PF03959.11 001020555.1_16123001_2 - 1.4e-64 217.6 0.0 1.6e-64 217.3 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.14 001020555.1_16123001_2 - 6.5e-05 22.7 0.0 0.00016 21.5 0.0 1.6 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.18 001020555.1_16123001_2 - 0.0057 16.2 0.0 3.4 7.1 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Ripply PF14998.4 001039108.1_16122001_2 - 1.1e-34 118.7 0.2 1.9e-34 118.0 0.2 1.4 1 0 0 1 1 1 1 Transcription Regulator Adap_comp_sub PF00928.19 001327971.1_16126001_2 - 9.4e-36 123.4 0.0 1.4e-35 122.9 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family AAA PF00004.27 001020575.1_16127001_1 - 2.5e-22 79.6 0.0 4.1e-22 78.9 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.8 001020575.1_16127001_1 - 1.4e-06 28.1 0.0 4.4e-06 26.5 0.0 1.9 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_5 PF07728.12 001020575.1_16127001_1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Peptidase_C1 PF00112.21 001005999.1_16123001_2 - 1.6e-82 276.8 0.7 1.9e-82 276.5 0.7 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 001005999.1_16123001_2 - 2.7e-05 24.4 0.2 5.1e-05 23.5 0.2 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 001005999.1_16123001_2 - 0.00028 19.6 1.9 0.05 12.2 0.3 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Inhibitor_I29 PF08246.10 001005999.1_16123001_3 - 1 9.7 3.8 1.7 9.0 3.8 1.3 1 0 0 1 1 1 0 Cathepsin propeptide inhibitor domain (I29) DM PF00751.16 130952.1_16125001_3 - 1.7e-21 75.7 12.9 3.2e-21 74.8 12.9 1.5 1 0 0 1 1 1 1 DM DNA binding domain Astacin PF01400.22 001030281.2_16125001_2 - 1.4e-65 220.3 0.0 2.7e-65 219.4 0.0 1.4 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) MAM PF00629.21 001030281.2_16125001_2 - 1.3e-30 106.3 0.2 2.1e-30 105.6 0.2 1.4 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu Tubulin PF00091.23 001328501.1_16124001_1 - 6.2e-10 39.5 0.1 9.2e-10 38.9 0.1 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.7 001328501.1_16124001_1 - 0.013 15.6 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain Tubulin PF00091.23 001328501.1_16124001_3 - 9.5e-53 179.2 0.0 1.6e-52 178.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001328501.1_16124001_3 - 2.1e-40 137.7 0.0 3.4e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 001328501.1_16124001_3 - 0.023 14.2 0.0 0.052 13.1 0.0 1.6 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.4 001328501.1_16124001_3 - 0.034 13.2 0.0 0.061 12.4 0.0 1.3 1 0 0 1 1 1 0 Tubulin like DUF775 PF05603.10 001017577.1_16122001_2 - 1.7e-54 184.2 0.0 1.7e-54 184.2 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF775) PRY PF13765.4 001328162.1_16125001_3 - 1.3e-14 53.4 0.3 3e-14 52.2 0.3 1.7 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 001328162.1_16125001_3 - 4.6e-13 49.2 0.0 8.2e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 001328162.1_16125001_3 - 0.00039 20.4 10.1 0.00039 20.4 10.1 3.1 3 0 0 3 3 3 1 B-box zinc finger BshC PF10079.7 001328162.1_16125001_3 - 0.032 12.8 9.6 0.055 12.1 9.6 1.3 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC DUF883 PF05957.11 001328162.1_16125001_3 - 2.4 8.7 5.8 2.3 8.7 1.9 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) UBA PF00627.29 001080561.1_16124001_3 - 3e-12 46.1 1.0 5.6e-12 45.2 1.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain MgtC PF02308.14 001080561.1_16124001_3 - 0.1 12.8 0.1 0.23 11.7 0.1 1.5 1 0 0 1 1 1 0 MgtC family XRCC4 PF06632.10 200786.1_16123001_2 - 6.1e-139 462.4 8.1 7.4e-139 462.1 8.1 1.0 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 REV PF00424.16 200786.1_16123001_3 - 0.56 10.1 9.7 2.8 7.9 9.6 2.2 1 1 0 1 1 1 0 REV protein (anti-repression trans-activator protein) zf-C2H2 PF00096.24 001326592.1_16127001_3 - 2.3e-29 100.0 70.1 3.8e-05 23.8 0.3 11.1 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001326592.1_16127001_3 - 2.2e-20 72.0 55.6 2e-07 31.0 0.1 9.2 9 1 0 9 9 9 5 Zinc-finger double domain zf-C2H2_4 PF13894.4 001326592.1_16127001_3 - 3.5e-09 36.6 102.9 0.011 16.4 0.2 11.5 13 0 0 13 13 13 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001326592.1_16127001_3 - 3.4e-08 33.5 19.4 0.2 11.9 0.3 7.5 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 001326592.1_16127001_3 - 1.5 9.0 11.0 3.5 7.8 0.3 3.2 2 1 0 3 3 3 0 zinc-finger-containing domain zf-met PF12874.5 001326592.1_16127001_3 - 6.3 7.2 46.0 0.092 13.0 0.5 7.8 9 0 0 9 9 9 0 Zinc-finger of C2H2 type Galactosyl_T PF01762.19 001128726.1_16123001_1 - 6.5e-50 169.5 0.0 8.5e-50 169.2 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.14 001128726.1_16123001_1 - 0.026 13.8 0.1 0.045 13.0 0.1 1.4 1 1 0 1 1 1 0 Fringe-like IFP_35_N PF07334.11 001013514.2_16126001_2 - 0.12 12.4 0.0 0.12 12.4 0.0 2.4 3 0 0 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus zf-RING_2 PF13639.4 201021.1_16126001_1 - 1.4e-11 44.3 6.1 1.4e-11 44.3 6.1 2.8 3 0 0 3 3 3 1 Ring finger domain zf-RING_11 PF17123.3 201021.1_16126001_1 - 1.1e-10 40.9 4.7 1.1e-10 40.9 4.7 3.3 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_UBOX PF13445.4 201021.1_16126001_1 - 2.3e-06 27.4 5.5 4.5e-06 26.4 2.2 3.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 201021.1_16126001_1 - 7.9e-06 25.5 5.9 7.9e-06 25.5 5.9 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 201021.1_16126001_1 - 8.4e-06 25.9 3.4 8.4e-06 25.9 3.4 2.6 3 0 0 3 3 3 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 201021.1_16126001_1 - 8.8e-05 22.2 3.9 8.8e-05 22.2 3.9 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 201021.1_16126001_1 - 0.00021 20.9 2.5 0.00021 20.9 2.5 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 201021.1_16126001_1 - 0.00022 21.0 2.2 0.00022 21.0 2.2 2.6 2 0 0 2 2 2 1 zinc-RING finger domain Zn_ribbon_17 PF17120.3 201021.1_16126001_1 - 0.0019 17.6 3.3 0.0059 16.1 3.3 1.8 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.4 201021.1_16126001_1 - 0.0099 15.6 2.3 0.0099 15.6 2.3 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3H2C3 PF17122.3 201021.1_16126001_1 - 1.5 8.8 5.5 1.2 9.1 3.3 2.1 2 0 0 2 2 2 0 Zinc-finger PI-PLC-X PF00388.17 001105700.1_16123001_3 - 8.8e-06 25.2 0.1 1.6e-05 24.4 0.1 1.5 1 1 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain zf-HC5HC2H PF13771.4 001003822.1_16127001_2 - 2.6e-16 59.5 3.5 2.6e-16 59.5 3.5 4.7 4 1 0 4 4 4 1 PHD-like zinc-binding domain HECT PF00632.23 001003822.1_16127001_2 - 2.8e-09 36.8 0.3 4.6e-09 36.1 0.3 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) zf-RING_2 PF13639.4 001003822.1_16127001_2 - 0.0057 16.7 9.8 0.0057 16.7 9.8 3.9 4 1 0 4 4 4 1 Ring finger domain zf-TFIIB PF13453.4 001003822.1_16127001_2 - 0.052 12.8 1.6 0.2 10.9 1.6 2.0 1 0 0 1 1 1 0 Transcription factor zinc-finger zf-RING_11 PF17123.3 001003822.1_16127001_2 - 4.3 7.0 10.8 0.78 9.4 6.2 2.4 2 0 0 2 2 2 0 RING-like zinc finger Transthyretin PF00576.19 001200021.3_16123001_2 - 2.3e-33 115.0 0.0 4e-33 114.3 0.0 1.4 1 0 0 1 1 1 1 HIUase/Transthyretin family SRP9-21 PF05486.10 201096.3_16124001_3 - 7.7e-12 45.3 0.3 9.9e-11 41.8 0.3 2.1 1 1 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) zf-H2C2_2 PF13465.4 001045150.1_16128001_1 - 2.6e-26 90.7 43.5 1.8e-07 31.1 0.7 9.3 9 0 0 9 9 9 6 Zinc-finger double domain zf-C2H2 PF00096.24 001045150.1_16128001_1 - 2.4e-24 84.2 56.3 8.9e-05 22.6 0.2 8.4 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001045150.1_16128001_1 - 3.1e-22 77.2 58.1 0.0007 20.1 1.1 8.7 8 0 0 8 8 8 7 C2H2-type zinc finger zf-met PF12874.5 001045150.1_16128001_1 - 4.9e-16 58.4 45.0 0.0055 16.9 0.3 8.2 8 0 0 8 8 7 6 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001045150.1_16128001_1 - 1.7e-14 53.5 31.4 0.00098 19.2 0.8 7.7 8 0 0 8 8 7 4 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 001045150.1_16128001_1 - 0.0025 17.4 39.2 0.44 10.2 0.1 7.5 7 0 0 7 7 7 3 zinc-finger C2H2-type NinF PF05810.10 001045150.1_16128001_1 - 0.0057 16.4 0.5 0.034 13.9 0.5 2.4 1 0 0 1 1 1 1 NinF protein zf-Di19 PF05605.10 001045150.1_16128001_1 - 0.0082 16.3 23.6 0.066 13.4 1.7 4.2 4 0 0 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.3 001045150.1_16128001_1 - 0.039 14.1 17.7 0.16 12.1 1.0 4.4 5 0 0 5 5 4 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.4 001045150.1_16128001_1 - 0.059 13.2 51.0 0.23 11.3 1.0 7.9 8 0 0 8 8 7 0 C2H2-type zinc finger UBZ_FAAP20 PF15750.3 001045150.1_16128001_1 - 0.11 12.3 0.9 1.4 8.8 0.1 3.1 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger DUF2225 PF09986.7 001045150.1_16128001_1 - 0.32 10.5 0.0 0.32 10.5 0.0 2.8 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) Desulfoferrod_N PF06397.10 001045150.1_16128001_1 - 0.69 9.5 7.2 3.5 7.2 0.3 3.7 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain Rad50_zn_hook PF04423.12 001045150.1_16128001_1 - 0.74 9.6 4.5 7.5 6.4 0.0 4.3 4 0 0 4 4 4 0 Rad50 zinc hook motif Elf1 PF05129.11 001045150.1_16128001_1 - 0.98 9.4 18.9 4.5 7.2 0.3 5.0 3 1 1 4 4 4 0 Transcription elongation factor Elf1 like DUF3449 PF11931.6 001045150.1_16128001_1 - 1 9.0 7.0 5.3 6.7 0.7 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) DUF3268 PF11672.6 001045150.1_16128001_1 - 1.5 9.1 15.0 0.72 10.1 0.2 4.5 4 2 1 5 5 5 0 zinc-finger-containing domain BolA PF01722.16 001045150.1_16128001_1 - 2.8 8.2 5.6 51 4.1 0.1 3.9 3 0 0 3 3 3 0 BolA-like protein WH1 PF00568.21 001113215.2_16128001_2 - 1.3e-10 41.0 0.0 2.3e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 WH1 domain Sprouty PF05210.11 001113215.2_16128001_3 - 4.9e-23 81.5 24.2 1.3e-22 80.1 24.2 1.8 1 0 0 1 1 1 1 Sprouty protein (Spry) Neur_chan_LBD PF02931.21 001003587.1_16125001_1 - 4.4e-49 166.7 0.4 6.3e-49 166.2 0.4 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 001003587.1_16125001_1 - 8.5e-32 111.0 3.0 4.4e-31 108.6 3.0 2.0 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region adh_short PF00106.23 001256719.1_16126001_3 - 1.1e-29 103.1 0.0 3.5e-29 101.5 0.0 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001256719.1_16126001_3 - 2.3e-15 56.6 0.0 9.1e-15 54.7 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001256719.1_16126001_3 - 2.5e-05 24.2 0.1 4.5e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 001256719.1_16126001_3 - 0.001 18.4 0.1 0.0034 16.7 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family CLZ PF16526.3 001145590.1_16123001_1 - 0.015 15.5 0.7 0.023 14.9 0.7 1.3 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Pkinase PF00069.23 001177454.1_16126001_3 - 9e-69 231.6 0.0 1.4e-68 231.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001177454.1_16126001_3 - 5e-33 114.3 0.0 7.4e-33 113.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 001177454.1_16126001_3 - 1.2e-25 89.0 22.1 1e-12 47.6 3.6 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.4 001177454.1_16126001_3 - 5.5e-06 25.8 0.0 0.00038 19.7 0.0 2.5 2 1 1 3 3 3 1 Kinase-like PH PF00169.27 001177454.1_16126001_3 - 4.6e-05 23.7 0.0 0.00012 22.4 0.0 1.8 1 0 0 1 1 1 1 PH domain Kdo PF06293.12 001177454.1_16126001_3 - 0.00039 19.7 0.0 0.0008 18.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family C1_2 PF03107.14 001177454.1_16126001_3 - 0.0015 18.7 19.2 0.031 14.5 2.9 2.6 2 0 0 2 2 2 2 C1 domain ABC1 PF03109.14 001177454.1_16126001_3 - 0.034 14.2 0.0 0.065 13.3 0.0 1.5 1 0 0 1 1 1 0 ABC1 family Glt_symporter PF03616.12 001177454.1_16126001_3 - 0.17 10.4 0.0 0.25 9.9 0.0 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter OrfB_Zn_ribbon PF07282.9 001177454.1_16126001_3 - 0.2 11.5 9.2 0.44 10.4 0.4 2.5 2 0 0 2 2 2 0 Putative transposase DNA-binding domain FYVE_2 PF02318.14 001177454.1_16126001_3 - 0.81 9.8 12.1 6.1 6.9 0.6 2.4 2 0 0 2 2 2 0 FYVE-type zinc finger PHD_2 PF13831.4 001177454.1_16126001_3 - 0.83 9.1 9.6 0.79 9.2 0.0 2.9 3 0 0 3 3 3 0 PHD-finger RRM_5 PF13893.4 001100007.1_16126001_2 - 1.3e-50 170.0 1.6 1.2e-37 128.2 0.0 4.1 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 001100007.1_16126001_2 - 5.2e-32 109.3 0.5 8.5e-09 35.0 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001100007.1_16126001_2 - 2.1e-13 49.8 0.7 0.0014 18.3 0.0 4.5 4 1 1 5 5 5 4 Occluded RNA-recognition motif Limkain-b1 PF11608.6 001100007.1_16126001_2 - 1.8e-05 24.6 0.0 0.71 9.9 0.0 3.4 3 0 0 3 3 3 2 Limkain b1 BRAP2 PF07576.10 001100007.1_16126001_2 - 0.086 12.9 0.5 5.5 7.1 0.1 3.3 4 0 0 4 4 4 0 BRCA1-associated protein 2 Glycolytic PF00274.17 194377.2_16124001_2 - 3.1e-186 618.0 0.0 3.7e-186 617.8 0.0 1.1 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I ANAPC4_WD40 PF12894.5 001020759.1_16126001_3 - 4e-07 30.1 2.7 2 8.6 0.3 6.0 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 001020759.1_16126001_3 - 2.1e-05 25.1 13.5 0.23 12.3 0.2 6.6 7 0 0 7 7 7 2 WD domain, G-beta repeat RRM_1 PF00076.20 001114590.1_16126001_1 - 7.9e-32 108.8 0.0 3.8e-15 55.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 001114590.1_16126001_1 - 0.00022 21.1 0.0 0.0021 17.9 0.0 2.2 2 0 0 2 2 2 1 RNA binding motif RRM_7 PF16367.3 001114590.1_16126001_1 - 0.0013 18.6 0.0 1 9.4 0.0 3.3 3 0 0 3 3 3 1 RNA recognition motif Nup35_RRM_2 PF14605.4 001114590.1_16126001_1 - 0.0038 17.0 0.1 0.061 13.2 0.0 2.5 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.6 001114590.1_16126001_1 - 0.11 12.5 0.1 0.51 10.3 0.0 2.1 3 0 0 3 3 3 0 Limkain b1 Folate_rec PF03024.12 001020730.1_16124001_2 - 2e-48 164.4 17.0 2.9e-48 163.9 17.0 1.2 1 0 0 1 1 1 1 Folate receptor family IQ PF00612.25 001128780.1_16122001_1 - 1.6e-05 24.2 0.3 1.6e-05 24.2 0.3 1.8 2 0 0 2 2 2 1 IQ calmodulin-binding motif Dpy-30 PF05186.11 001128780.1_16122001_1 - 0.0018 17.8 0.1 0.53 9.9 0.0 2.4 2 0 0 2 2 2 2 Dpy-30 motif Peptidase_C2 PF00648.19 001004571.1_16127001_3 - 2.3e-140 466.6 2.3 3.5e-140 466.0 2.3 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 001004571.1_16127001_3 - 6.8e-56 188.3 0.0 1.9e-55 186.9 0.0 1.8 2 0 0 2 2 2 1 Calpain large subunit, domain III EF-hand_1 PF00036.30 001004571.1_16127001_3 - 7.8e-13 46.9 1.7 0.00015 20.9 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 001004571.1_16127001_3 - 5.1e-11 41.5 0.4 0.00087 18.9 0.1 4.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 001004571.1_16127001_3 - 2.7e-07 30.1 4.3 3.7e-06 26.5 0.1 4.2 4 1 0 4 4 4 1 EF-hand domain pair EF-hand_7 PF13499.4 001004571.1_16127001_3 - 1.3e-05 25.4 4.8 0.16 12.3 0.6 4.1 3 2 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.4 001004571.1_16127001_3 - 0.0013 18.0 0.4 0.066 12.6 0.0 2.9 2 0 0 2 2 2 1 EF hand Alpha_adaptin_C PF02296.14 001004571.1_16127001_3 - 0.3 11.2 2.1 0.25 11.4 0.1 1.9 2 0 0 2 2 2 0 Alpha adaptin AP2, C-terminal domain ACBP PF00887.17 199608.2_16123001_2 - 2.4e-29 101.2 2.9 3.6e-29 100.7 2.9 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein RRM_1 PF00076.20 001002382.1_16123001_2 - 8.6e-28 95.8 0.1 1.9e-16 59.5 0.0 3.5 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001002382.1_16123001_2 - 3.5e-09 36.5 0.1 0.0014 18.6 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif RRM_occluded PF16842.3 001002382.1_16123001_2 - 0.013 15.2 0.0 2.4 7.9 0.0 2.9 2 1 0 2 2 2 0 Occluded RNA-recognition motif TNFR_c6 PF00020.16 001045424.1_16124001_2 - 9.2e-22 77.1 87.4 3.5e-08 33.6 8.2 7.4 8 1 1 9 9 9 7 TNFR/NGFR cysteine-rich region Ribosomal_L7Ae PF01248.24 001282177.1_16122001_1 - 2.1e-29 100.9 1.4 2.7e-29 100.6 1.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF3504 PF12012.6 001044320.2_16128001_3 - 4.9e-58 195.5 0.0 1.5e-57 193.9 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3504) zf-FCS PF06467.12 001044320.2_16128001_3 - 4.8e-16 58.3 83.8 3.1e-05 23.7 4.9 10.8 9 2 1 10 10 10 8 MYM-type Zinc finger with FCS sequence motif 7tm_1 PF00001.19 001079657.1_16125001_1 - 3.1e-34 118.3 15.4 3.1e-34 118.3 15.4 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Methyltransf_23 PF13489.4 001040381.1_16123001_1 - 1.9e-13 50.5 0.0 3e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 001040381.1_16123001_1 - 1.2e-12 48.2 0.0 2.6e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001040381.1_16123001_1 - 6.7e-12 45.8 0.0 1.3e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001040381.1_16123001_1 - 7.8e-08 32.1 0.0 1.3e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001040381.1_16123001_1 - 2.5e-07 31.2 0.0 6.8e-07 29.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 001040381.1_16123001_1 - 1.3e-05 24.6 0.1 1.8e-05 24.1 0.1 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.12 001040381.1_16123001_1 - 0.00014 21.3 0.0 0.00024 20.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.9 001040381.1_16123001_1 - 0.00068 18.5 0.2 0.0015 17.4 0.1 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1698) TehB PF03848.12 001040381.1_16123001_1 - 0.0039 16.5 0.0 0.011 15.0 0.0 1.6 2 0 0 2 2 2 1 Tellurite resistance protein TehB PrmA PF06325.11 001040381.1_16123001_1 - 0.0093 15.3 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DREV PF05219.10 001040381.1_16123001_1 - 0.03 13.3 0.0 0.045 12.7 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_19 PF04672.10 001040381.1_16123001_1 - 0.091 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl methyltransferase MetW PF07021.10 001040381.1_16123001_1 - 0.11 11.9 0.1 0.25 10.8 0.0 1.6 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW Glyco_transf_29 PF00777.16 001004017.1_16123001_1 - 1.1e-80 270.7 0.1 1.4e-80 270.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) G_glu_transpept PF01019.19 001004017.1_16123001_1 - 0.073 11.7 0.0 0.1 11.2 0.0 1.1 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase HupH_C PF04809.11 001004017.1_16123001_1 - 0.075 12.6 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 HupH hydrogenase expression protein, C-terminal conserved region LRR_6 PF13516.4 001098191.1_16125001_1 - 6.9e-05 22.5 7.0 0.064 13.2 0.0 5.5 6 0 0 6 6 6 2 Leucine Rich repeat LRR_4 PF12799.5 001098191.1_16125001_1 - 0.021 15.1 24.9 0.52 10.7 0.1 7.7 5 2 4 9 9 9 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001098191.1_16125001_1 - 0.033 14.5 5.7 14 6.5 0.1 5.1 3 1 0 3 3 3 0 Leucine Rich Repeat Pkinase PF00069.23 001114476.1_16126001_3 - 2.5e-76 256.4 0.0 3.6e-76 255.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001114476.1_16126001_3 - 1.2e-44 152.4 0.0 1.7e-44 151.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.17 001114476.1_16126001_3 - 8.6e-21 73.3 0.0 1.6e-20 72.5 0.0 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.4 001114476.1_16126001_3 - 6e-07 28.9 0.0 1.5e-06 27.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like UBA PF00627.29 001114476.1_16126001_3 - 3.8e-06 26.6 0.0 7e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain RIO1 PF01163.20 001114476.1_16126001_3 - 0.00035 20.1 0.3 0.00064 19.2 0.3 1.3 1 0 0 1 1 1 1 RIO1 family UBA_2 PF08587.9 001114476.1_16126001_3 - 0.0029 17.6 0.1 0.0065 16.5 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kdo PF06293.12 001114476.1_16126001_3 - 0.0037 16.5 0.2 0.0069 15.6 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001114476.1_16126001_3 - 0.17 11.7 0.1 0.5 10.1 0.1 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF2970 PF11174.6 200543.1_16124001_1 - 1.8 8.4 7.7 2.9 7.7 7.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2970) Syntaxin PF00804.23 200543.1_16124001_2 - 1.9e-59 200.6 13.2 1.9e-59 200.6 13.2 1.5 2 0 0 2 2 1 1 Syntaxin SNARE PF05739.17 200543.1_16124001_2 - 2.8e-16 59.1 4.1 2.8e-16 59.1 4.1 3.0 3 0 0 3 3 3 1 SNARE domain Syntaxin_2 PF14523.4 200543.1_16124001_2 - 1.5e-09 38.0 5.5 1.5e-09 38.0 5.5 1.7 2 0 0 2 2 2 1 Syntaxin-like protein TRIQK PF15168.4 200543.1_16124001_2 - 0.0083 15.9 0.8 0.021 14.6 0.8 1.7 1 0 0 1 1 1 1 Triple QxxK/R motif-containing protein family FlaC_arch PF05377.9 200543.1_16124001_2 - 0.0099 16.1 0.8 0.0099 16.1 0.8 3.6 3 2 1 4 4 4 1 Flagella accessory protein C (FlaC) DUF5082 PF16888.3 200543.1_16124001_2 - 0.011 15.9 5.8 1.1 9.5 2.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) AAA_13 PF13166.4 200543.1_16124001_2 - 0.03 12.9 14.0 0.043 12.3 14.0 1.1 1 0 0 1 1 1 0 AAA domain Prominin PF05478.9 200543.1_16124001_2 - 0.041 11.7 13.7 0.2 9.4 0.6 2.1 2 0 0 2 2 2 0 Prominin ETRAMP PF09716.8 200543.1_16124001_2 - 0.083 12.8 0.3 0.083 12.8 0.3 3.5 3 1 0 3 3 2 0 Malarial early transcribed membrane protein (ETRAMP) Nup54 PF13874.4 200543.1_16124001_2 - 0.16 12.0 2.6 0.48 10.4 2.6 1.9 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Baculo_PEP_C PF04513.10 200543.1_16124001_2 - 0.28 11.1 4.0 0.36 10.7 1.9 2.0 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2207 PF09972.7 200543.1_16124001_2 - 0.28 9.8 2.4 0.56 8.8 0.0 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Fib_alpha PF08702.8 200543.1_16124001_2 - 0.54 10.3 9.0 0.21 11.6 3.5 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Alanine_zipper PF11839.6 200543.1_16124001_2 - 0.62 10.2 5.9 17 5.7 0.2 3.1 2 1 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein PBP_dimer PF03717.13 200543.1_16124001_2 - 4.1 7.6 6.8 7.8 6.7 3.8 2.1 1 1 1 2 2 2 0 Penicillin-binding Protein dimerisation domain Syntaxin-6_N PF09177.9 200543.1_16124001_2 - 5 7.6 7.5 0.74 10.3 2.6 2.2 2 1 1 3 3 3 0 Syntaxin 6, N-terminal COG2 PF06148.9 200543.1_16124001_2 - 9.3 6.2 10.6 3.2 7.7 0.3 3.1 2 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Cyt-b5 PF00173.26 212876.1_16124001_1 - 1.8e-24 85.5 0.1 2.8e-24 84.9 0.1 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain B3_4 PF03483.15 001007768.1_16125001_3 - 2.6e-26 92.2 0.1 4.5e-26 91.4 0.1 1.4 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.13 001007768.1_16125001_3 - 7e-16 58.1 0.0 7.1e-14 51.7 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetase B5 domain Not3 PF04065.13 001328118.1_16129001_3 - 6.6e-96 320.1 31.9 8.7e-96 319.7 31.9 1.1 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.16 001328118.1_16129001_3 - 4.1e-39 133.5 10.3 1.3e-38 132.0 10.3 1.9 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family ZnuA PF01297.15 001328118.1_16129001_3 - 0.19 11.0 2.4 0.34 10.2 2.4 1.4 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic Syntaxin_2 PF14523.4 001328118.1_16129001_3 - 0.67 10.2 12.2 0.57 10.4 1.6 2.6 2 0 0 2 2 2 0 Syntaxin-like protein DUF4407 PF14362.4 001328118.1_16129001_3 - 1.4 8.1 12.9 2.1 7.5 12.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Swi5 PF07061.9 001328118.1_16129001_3 - 4.5 7.3 9.4 3.1 7.8 1.0 2.5 2 0 0 2 2 2 0 Swi5 SUI1 PF01253.20 201162.1_16125001_1 - 5e-18 65.3 0.1 5e-18 65.3 0.1 1.9 2 0 0 2 2 2 1 Translation initiation factor SUI1 PUA PF01472.18 201162.1_16125001_1 - 1.3e-06 28.1 0.4 3.2e-06 26.9 0.1 1.8 2 0 0 2 2 2 1 PUA domain SWIB PF02201.16 201162.1_16125001_1 - 0.0029 17.3 0.2 0.0075 16.0 0.2 1.7 1 0 0 1 1 1 1 SWIB/MDM2 domain Ca_chan_IQ PF08763.9 201162.1_16125001_1 - 0.0092 16.1 2.0 0.052 13.7 0.0 2.8 3 0 0 3 3 3 1 Voltage gated calcium channel IQ domain Elf1 PF05129.11 200386.1_16123001_2 - 2.5e-30 104.2 1.7 2.5e-30 104.2 1.7 1.7 2 0 0 2 2 2 1 Transcription elongation factor Elf1 like zf-C3HC4_4 PF15227.4 001044914.1_16129001_1 - 1.5e-11 44.1 9.0 1.5e-11 44.1 9.0 3.3 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 001044914.1_16129001_1 - 4.1e-10 39.4 5.9 1.5e-09 37.6 5.9 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001044914.1_16129001_1 - 4.2e-10 39.2 8.5 4.2e-10 39.2 8.5 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001044914.1_16129001_1 - 2.7e-08 33.4 8.8 2.7e-08 33.4 8.8 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001044914.1_16129001_1 - 2.5e-05 24.3 8.8 2.5e-05 24.3 8.8 4.0 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.4 001044914.1_16129001_1 - 7e-05 22.5 6.9 7e-05 22.5 6.9 3.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001044914.1_16129001_1 - 0.00045 20.0 7.2 0.00045 20.0 7.2 3.6 2 1 0 2 2 2 1 zinc-RING finger domain DUF3287 PF11690.6 001044914.1_16129001_1 - 0.0036 16.9 1.1 0.0078 15.8 1.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3287) zf-Nse PF11789.6 001044914.1_16129001_1 - 0.022 14.4 5.4 0.057 13.1 5.4 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Exonuc_VII_L PF02601.13 001044914.1_16129001_1 - 1.2 8.5 3.7 1.9 7.8 3.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit PARP PF00644.18 001278831.1_16122001_2 - 3.1e-07 30.1 0.0 4.5e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Thymosin PF01290.18 001130697.1_16122001_1 - 1.4e-19 69.3 10.6 2.3e-19 68.6 10.6 1.4 1 0 0 1 1 1 1 Thymosin beta-4 family DUF4522 PF15022.4 001130697.1_16122001_1 - 0.11 12.6 1.2 0.13 12.4 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4522) BAR PF03114.16 200301.1_16123001_3 - 1.9e-79 266.5 7.2 2.7e-79 266.1 7.2 1.2 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.4 200301.1_16123001_3 - 1.5e-12 47.0 0.3 2.8e-12 46.1 0.3 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 200301.1_16123001_3 - 3.2e-12 45.7 0.2 7.4e-12 44.5 0.1 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 200301.1_16123001_3 - 2.9e-10 39.6 0.0 5.4e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR_2 PF10455.7 200301.1_16123001_3 - 1.9e-09 36.9 2.6 2.1e-07 30.3 0.6 2.1 2 0 0 2 2 2 2 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.3 200301.1_16123001_3 - 0.00044 19.9 4.1 0.0015 18.1 3.7 2.2 1 1 0 1 1 1 1 BAR domain of APPL family Arfaptin PF06456.11 200301.1_16123001_3 - 0.00083 18.9 1.0 0.0017 17.9 0.3 1.8 1 1 1 2 2 2 1 Arfaptin-like domain Herpes_ICP4_N PF03584.13 200301.1_16123001_3 - 0.06 13.1 0.1 0.097 12.4 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus ICP4-like protein N-terminal region F-box-like PF12937.5 001328023.1_16123001_3 - 6e-11 41.9 0.1 1.5e-10 40.7 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001328023.1_16123001_3 - 7.5e-05 22.4 0.1 0.00019 21.1 0.1 1.6 1 0 0 1 1 1 1 F-box domain Beta_helix PF13229.4 001135257.1_16127001_3 - 8.2e-45 152.4 33.3 7.8e-15 54.9 4.8 5.2 3 2 2 5 5 5 4 Right handed beta helix region NosD PF05048.11 001135257.1_16127001_3 - 3.8e-32 111.3 13.3 1.5e-09 37.4 0.2 4.3 2 2 2 4 4 4 4 Periplasmic copper-binding protein (NosD) F-box-like PF12937.5 001135257.1_16127001_3 - 4.7e-09 35.9 4.6 1.2e-08 34.5 4.6 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001135257.1_16127001_3 - 1.2e-08 34.4 5.8 2.6e-08 33.4 4.8 2.1 1 1 1 2 2 2 1 F-box domain F-box-like PF12937.5 001122628.1_16125001_3 - 1.9e-10 40.3 3.9 4.3e-10 39.2 3.9 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001122628.1_16125001_3 - 4.5e-05 23.1 1.2 4.5e-05 23.1 1.2 2.2 2 0 0 2 2 2 1 F-box domain WD40 PF00400.30 001122628.1_16125001_3 - 0.0015 19.2 8.5 1.6 9.6 2.6 5.4 4 1 0 4 4 4 2 WD domain, G-beta repeat PQQ_2 PF13360.4 001122628.1_16125001_3 - 0.088 12.2 0.1 0.21 11.0 0.1 1.5 1 0 0 1 1 1 0 PQQ-like domain TSP_1 PF00090.17 001122760.1_16129001_1 - 1.6e-42 143.3 209.6 3.2e-09 36.7 1.7 23.1 21 1 0 21 21 21 16 Thrombospondin type 1 domain CCDC71L PF15374.4 001122760.1_16129001_1 - 1.6 7.8 11.3 2.7 7.0 11.3 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L GDA1_CD39 PF01150.15 001003545.1_16125001_1 - 1.6e-127 425.6 0.1 2.1e-127 425.2 0.1 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Peptidase_S49_N PF08496.8 213120.1_16125001_1 - 0.71 9.8 7.3 1.1 9.2 7.3 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal zf-C2H2 PF00096.24 213120.1_16125001_2 - 1.8e-16 59.4 24.7 4.1e-05 23.7 0.4 5.2 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 213120.1_16125001_2 - 8.1e-15 54.4 22.4 5.2e-07 29.7 0.2 5.0 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 213120.1_16125001_2 - 5.4e-11 42.2 20.6 0.041 14.6 0.2 5.0 4 0 0 4 4 4 4 C2H2-type zinc finger Raffinose_syn PF05691.10 213120.1_16125001_2 - 0.058 11.1 0.0 0.086 10.5 0.0 1.1 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 AP3D1 PF06375.9 213120.1_16125001_2 - 0.2 11.8 14.1 0.078 13.1 11.2 1.8 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 CCAP PF11105.6 213120.1_16125001_2 - 0.44 10.4 4.5 2.3 8.1 0.8 2.5 1 1 1 2 2 2 0 Arthropod cardioacceleratory peptide 2a zf-C2H2_11 PF16622.3 213120.1_16125001_2 - 2.3 7.9 7.1 7.1 6.4 0.4 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type adh_short PF00106.23 001099999.1_16123001_3 - 1.3e-09 37.7 0.0 1.7e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001099999.1_16123001_3 - 9.1e-09 35.1 0.0 1.3e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 3HCDH_N PF02737.16 001099999.1_16123001_3 - 0.00039 20.2 0.2 0.0017 18.1 0.1 1.8 1 1 1 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NmrA PF05368.11 001099999.1_16123001_3 - 0.0068 15.8 0.1 0.019 14.4 0.2 1.7 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.4 001099999.1_16123001_3 - 0.011 15.5 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding F420_oxidored PF03807.15 001099999.1_16123001_3 - 0.03 14.8 0.2 0.1 13.1 0.1 1.9 1 1 1 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.19 001099999.1_16123001_3 - 0.037 13.3 0.1 0.054 12.8 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_2 PF03446.13 001099999.1_16123001_3 - 0.11 12.5 0.1 0.36 10.9 0.1 1.8 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.18 001099999.1_16123001_3 - 0.16 11.9 0.1 0.32 10.9 0.1 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase REV PF00424.16 001029967.3_16128001_1 - 0.14 12.1 11.1 0.56 10.1 4.1 2.9 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) Reticulon PF02453.15 001029967.3_16128001_3 - 5.1e-43 146.6 9.9 7.4e-43 146.1 9.9 1.2 1 0 0 1 1 1 1 Reticulon Ig_3 PF13927.4 001076627.1_16124001_3 - 6.7e-41 138.7 0.6 1.2e-08 35.3 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 001076627.1_16124001_3 - 7.3e-38 128.7 0.1 6.7e-10 39.1 0.0 5.9 5 2 0 5 5 5 5 Immunoglobulin domain I-set PF07679.14 001076627.1_16124001_3 - 6.8e-28 96.5 11.6 3.1e-05 23.8 0.2 6.9 4 2 0 5 5 5 5 Immunoglobulin I-set domain C2-set_2 PF08205.10 001076627.1_16124001_3 - 3e-25 88.0 0.0 6.4e-15 54.9 0.0 5.3 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain ig PF00047.23 001076627.1_16124001_3 - 8.5e-24 83.4 5.7 0.00012 22.1 0.0 7.0 5 2 0 5 5 5 5 Immunoglobulin domain V-set PF07686.15 001076627.1_16124001_3 - 7.8e-21 74.1 6.6 4.2e-10 39.6 0.0 6.2 4 2 1 6 6 6 3 Immunoglobulin V-set domain Ig_4 PF16680.3 001076627.1_16124001_3 - 5.3e-10 39.4 1.4 0.015 15.5 0.1 4.7 6 1 0 6 6 6 2 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.3 001076627.1_16124001_3 - 1.8e-08 34.6 1.7 0.018 15.3 0.0 4.7 5 0 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.13 001076627.1_16124001_3 - 1.5e-05 25.2 0.7 0.095 13.1 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin C1-set domain Cu2_monoox_C PF03712.13 001076627.1_16124001_3 - 0.00014 21.2 0.9 0.76 9.1 0.0 3.2 3 0 0 3 3 3 2 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Izumo-Ig PF16706.3 001076627.1_16124001_3 - 0.00025 20.9 0.4 0.045 13.7 0.1 3.8 3 1 0 3 3 3 1 Izumo-like Immunoglobulin domain Filament PF00038.19 001102641.1_16123001_2 - 1.2e-89 300.8 35.2 1.5e-89 300.6 35.2 1.0 1 0 0 1 1 1 1 Intermediate filament protein Reo_sigmaC PF04582.10 001102641.1_16123001_2 - 2.5e-05 23.7 11.2 0.0043 16.4 3.2 2.3 1 1 0 2 2 2 2 Reovirus sigma C capsid protein CENP-F_leu_zip PF10473.7 001102641.1_16123001_2 - 0.00029 20.8 34.9 0.13 12.2 5.5 4.8 2 1 1 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EzrA PF06160.10 001102641.1_16123001_2 - 0.00046 18.4 29.7 0.0013 16.9 11.5 3.0 2 1 1 3 3 3 2 Septation ring formation regulator, EzrA ATG16 PF08614.9 001102641.1_16123001_2 - 0.00049 20.2 36.5 0.019 15.0 4.2 3.8 1 1 3 4 4 4 3 Autophagy protein 16 (ATG16) Phage_Mu_Gam PF07352.10 001102641.1_16123001_2 - 0.00059 19.6 16.9 0.084 12.6 0.3 3.9 2 2 1 3 3 3 2 Bacteriophage Mu Gam like protein Spc7 PF08317.9 001102641.1_16123001_2 - 0.0021 16.9 10.5 0.0021 16.9 10.5 2.9 1 1 2 3 3 3 3 Spc7 kinetochore protein Aminopep PF10023.7 001102641.1_16123001_2 - 0.0031 16.8 12.9 0.006 15.8 3.5 2.1 2 0 0 2 2 2 2 Putative aminopeptidase DUF812 PF05667.9 001102641.1_16123001_2 - 0.0051 15.6 29.2 0.0055 15.5 5.5 2.7 1 1 1 2 2 2 1 Protein of unknown function (DUF812) APG6 PF04111.10 001102641.1_16123001_2 - 0.0083 15.4 13.7 0.0083 15.4 13.7 2.7 2 1 0 2 2 2 1 Autophagy protein Apg6 DUF4924 PF16271.3 001102641.1_16123001_2 - 0.017 15.0 3.4 0.017 15.0 3.4 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4924) TPR_MLP1_2 PF07926.10 001102641.1_16123001_2 - 0.035 14.0 38.4 0.11 12.4 2.2 4.7 2 2 1 4 4 4 0 TPR/MLP1/MLP2-like protein Fez1 PF06818.13 001102641.1_16123001_2 - 0.045 14.1 28.4 0.78 10.0 13.4 2.9 1 1 1 2 2 2 0 Fez1 HI0933_like PF03486.12 001102641.1_16123001_2 - 0.077 11.5 6.4 0.019 13.5 3.1 1.5 2 0 0 2 2 2 0 HI0933-like protein DUF148 PF02520.15 001102641.1_16123001_2 - 0.11 12.5 19.2 3.8 7.5 0.4 4.7 3 2 1 4 4 4 0 Domain of unknown function DUF148 DUF1664 PF07889.10 001102641.1_16123001_2 - 0.17 11.8 18.8 1.6 8.6 0.5 3.8 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.7 001102641.1_16123001_2 - 0.22 11.6 32.8 0.28 11.2 11.5 3.6 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 IncA PF04156.12 001102641.1_16123001_2 - 0.25 11.0 37.1 0.5 10.0 2.2 4.0 1 1 2 3 3 3 0 IncA protein DUF4047 PF13256.4 001102641.1_16123001_2 - 0.26 11.4 13.1 3.4 7.7 3.6 3.2 2 1 0 3 3 3 0 Domain of unknown function (DUF4047) Prominin PF05478.9 001102641.1_16123001_2 - 0.51 8.1 20.5 1.1 6.9 10.9 2.2 1 1 0 2 2 2 0 Prominin ERM PF00769.17 001102641.1_16123001_2 - 0.51 10.0 23.6 2.5 7.7 5.2 2.3 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF600 PF04634.10 001102641.1_16123001_2 - 0.6 10.0 7.1 0.38 10.7 0.3 3.2 1 1 2 3 3 3 0 Protein of unknown function, DUF600 Anillin_N PF16018.3 001102641.1_16123001_2 - 0.74 10.3 5.7 1.1 9.7 0.1 3.3 2 1 1 3 3 3 0 Anillin N-terminus Prefoldin PF02996.15 001102641.1_16123001_2 - 1.2 8.9 21.5 4 7.2 1.8 4.7 3 2 2 5 5 5 0 Prefoldin subunit ADIP PF11559.6 001102641.1_16123001_2 - 1.2 9.1 30.6 0.29 11.1 5.1 3.7 2 2 2 4 4 4 0 Afadin- and alpha -actinin-Binding FlaC_arch PF05377.9 001102641.1_16123001_2 - 1.8 8.9 17.5 21 5.4 0.2 5.3 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) Prefoldin_2 PF01920.18 001102641.1_16123001_2 - 2.6 7.9 26.4 0.6 10.0 0.1 5.0 3 2 0 4 4 4 0 Prefoldin subunit BRE1 PF08647.9 001102641.1_16123001_2 - 3.2 7.8 23.8 0.33 10.9 0.7 4.4 2 2 0 3 3 3 0 BRE1 E3 ubiquitin ligase Baculo_PEP_C PF04513.10 001102641.1_16123001_2 - 3.3 7.6 18.4 2.3 8.1 0.6 3.6 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF972 PF06156.11 001102641.1_16123001_2 - 6.2 7.4 36.4 0.076 13.5 1.8 5.3 1 1 4 5 5 5 0 Protein of unknown function (DUF972) TBPIP PF07106.11 001102641.1_16123001_2 - 6.7 6.3 28.8 0.21 11.2 9.7 3.9 1 1 3 4 4 4 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Atg14 PF10186.7 001102641.1_16123001_2 - 7.9 5.3 23.8 6.5 5.6 3.3 3.2 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Pex19 PF04614.10 001017399.1_16124001_2 - 1e-56 192.3 5.9 1e-56 192.3 5.9 1.6 2 0 0 2 2 2 1 Pex19 protein family EF-hand_6 PF13405.4 213638.1_16123001_2 - 8.1e-15 53.3 0.3 2.6e-07 29.9 0.1 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.30 213638.1_16123001_2 - 4.1e-14 50.9 2.8 1.2e-05 24.4 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 213638.1_16123001_2 - 1.3e-08 35.1 0.1 0.00052 20.3 0.0 2.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.4 213638.1_16123001_2 - 1.4e-05 24.6 2.0 0.053 13.2 0.0 3.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 213638.1_16123001_2 - 0.01 15.2 0.0 0.18 11.2 0.1 2.8 3 0 0 3 3 3 0 EF hand EF-hand_9 PF14658.4 213638.1_16123001_2 - 0.056 13.6 0.0 11 6.4 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain BAR PF03114.16 199796.1_16125001_1 - 5.6e-34 117.7 17.2 9.5e-34 117.0 17.2 1.3 1 0 0 1 1 1 1 BAR domain Flavi_NS1 PF00948.19 199796.1_16125001_1 - 1.7e-05 23.8 0.5 2.5e-05 23.2 0.5 1.2 1 0 0 1 1 1 1 Flavivirus non-structural Protein NS1 ENT PF03735.12 199796.1_16125001_1 - 0.12 12.4 2.1 1.4 9.0 0.3 2.6 2 0 0 2 2 2 0 ENT domain CK2S PF15011.4 199796.1_16125001_1 - 0.14 11.8 4.6 0.22 11.2 0.2 2.7 2 1 0 2 2 2 0 Casein Kinase 2 substrate GAS PF13851.4 199796.1_16125001_1 - 0.29 10.4 17.7 0.65 9.2 7.6 2.6 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding TMPIT PF07851.11 199796.1_16125001_1 - 2 7.5 13.5 0.57 9.2 3.5 2.6 2 1 0 2 2 2 0 TMPIT-like protein DUF948 PF06103.9 199796.1_16125001_1 - 2.6 8.2 4.5 12 6.1 0.1 3.2 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1043 PF06295.10 205564.2_16125001_3 - 0.0013 18.6 7.2 0.0041 17.0 7.2 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) BLOC1_2 PF10046.7 205564.2_16125001_3 - 0.16 12.1 12.6 0.1 12.8 7.3 2.9 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 BAR_3 PF16746.3 205564.2_16125001_3 - 0.89 9.0 13.4 0.025 14.1 5.6 2.3 3 0 0 3 3 3 0 BAR domain of APPL family Laminin_II PF06009.10 205564.2_16125001_3 - 1.3 8.9 12.4 15 5.4 5.6 3.6 4 0 0 4 4 4 0 Laminin Domain II UPF0240 PF06784.9 205564.2_16125001_3 - 2.3 8.1 6.8 0.48 10.3 1.7 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0240) Snapin_Pallidin PF14712.4 205564.2_16125001_3 - 3.5 8.0 18.5 0.47 10.8 3.4 4.6 3 2 2 5 5 5 0 Snapin/Pallidin CLZ PF16526.3 205564.2_16125001_3 - 6 7.2 24.5 0.35 11.1 1.3 4.4 3 1 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Pkinase PF00069.23 200045.1_16124001_2 - 1.5e-76 257.1 0.1 2e-76 256.7 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 200045.1_16124001_2 - 2.6e-33 115.3 0.0 3.6e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.24 200045.1_16124001_2 - 4.5e-13 49.2 0.0 8.7e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.4 200045.1_16124001_2 - 1.5e-08 34.2 0.0 2.2e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 200045.1_16124001_2 - 0.0003 20.3 0.2 0.00051 19.5 0.2 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.12 200045.1_16124001_2 - 0.013 14.8 0.1 0.02 14.1 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 200045.1_16124001_2 - 0.041 13.4 0.0 0.08 12.4 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Yop-YscD_cpl PF16697.3 200045.1_16124001_2 - 0.1 12.8 0.0 0.67 10.2 0.0 2.2 1 1 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Peroxin-13_N PF04088.11 200645.1_16126001_2 - 8.6e-45 152.4 0.1 1.7e-44 151.4 0.1 1.5 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_9 PF14604.4 200645.1_16126001_2 - 4.3e-10 39.2 0.0 7.3e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 200645.1_16126001_2 - 4.7e-06 26.0 0.0 8.6e-06 25.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 200645.1_16126001_2 - 6.3e-06 25.7 0.0 1.1e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Ifi-6-16 PF06140.11 001291934.1_16122001_2 - 1.6e-22 79.1 39.1 3e-22 78.2 39.1 1.4 1 0 0 1 1 1 1 Interferon-induced 6-16 family Glyco_transf_10 PF00852.17 001128773.1_16123001_3 - 7.3e-62 208.1 1.9 1.1e-61 207.5 1.9 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 001128773.1_16123001_3 - 2.6e-33 114.7 0.6 2.4e-32 111.5 0.1 2.4 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal Glyco_trans_1_2 PF13524.4 001128773.1_16123001_3 - 0.079 13.2 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_transf_29 PF00777.16 001003853.1_16123001_1 - 3.7e-38 131.3 0.0 5.8e-38 130.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) SNAP PF14938.4 001013480.2_16123001_2 - 2.8e-28 99.0 23.3 3.5e-28 98.7 23.3 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.4 001013480.2_16123001_2 - 0.0016 18.5 0.2 0.0016 18.5 0.2 3.9 2 1 2 4 4 4 3 Tetratricopeptide repeat RAG1_imp_bd PF12560.6 001013480.2_16123001_2 - 0.0034 16.8 1.3 0.081 12.3 0.2 2.2 1 1 1 2 2 2 1 RAG1 importin binding Sel1 PF08238.10 001013480.2_16123001_2 - 0.062 13.9 0.2 0.55 10.9 0.1 2.5 2 0 0 2 2 2 0 Sel1 repeat DHR-2 PF06920.11 001013480.2_16123001_2 - 0.078 11.5 7.5 0.11 11.0 7.5 1.2 1 0 0 1 1 1 0 Dock homology region 2 TPR_10 PF13374.4 001013480.2_16123001_2 - 0.23 11.3 2.4 5 7.0 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4810 PF16068.3 001013480.2_16123001_2 - 5.7 7.4 7.7 2.4 8.6 0.2 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4810) Glyco_transf_10 PF00852.17 001012374.1_16123001_1 - 3.2e-39 134.3 0.1 7.6e-39 133.1 0.1 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 001012374.1_16123001_1 - 5.9e-11 42.7 0.1 1.5e-10 41.3 0.1 1.7 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal FBP_C PF16571.3 001012374.1_16123001_1 - 0.073 12.5 0.1 0.17 11.2 0.1 1.6 1 0 0 1 1 1 0 FBP C-terminal treble-clef zinc-finger DUF3272 PF11676.6 001012374.1_16123001_2 - 0.093 12.9 0.4 0.17 12.0 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3272) ArfGap PF01412.16 001077778.1_16125001_3 - 1e-41 141.5 0.4 1e-41 141.5 0.4 1.6 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf p450 PF00067.20 200461.1_16124001_2 - 1.8e-89 300.5 0.0 2.4e-89 300.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 EF-hand_7 PF13499.4 001201489.1_16124001_1 - 1.3e-08 35.1 2.8 3.9e-08 33.5 1.7 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 001201489.1_16124001_1 - 4.2e-08 32.1 4.3 0.0012 18.1 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 001201489.1_16124001_1 - 4.2e-07 29.3 3.7 0.0029 17.3 0.1 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.4 001201489.1_16124001_1 - 0.00067 19.2 1.2 0.004 16.8 0.7 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.4 001201489.1_16124001_1 - 0.032 13.6 0.2 1 8.8 0.0 2.7 2 0 0 2 2 2 0 EF hand RRM_7 PF16367.3 001351713.1_16129001_2 - 4.4e-35 119.5 0.0 7.9e-34 115.5 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif CEBP_ZZ PF16366.3 001351713.1_16129001_2 - 8.7e-20 70.6 5.3 2e-19 69.4 5.3 1.7 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.20 001351713.1_16129001_2 - 2.5e-10 39.9 0.0 9.8e-06 25.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-B_box PF00643.22 001351713.1_16129001_2 - 1.8 8.7 5.6 6.8 6.8 5.6 2.0 1 0 0 1 1 1 0 B-box zinc finger Synuclein PF01387.15 001020652.1_16122001_1 - 3.1e-39 134.1 16.7 4.1e-39 133.7 16.7 1.1 1 0 0 1 1 1 1 Synuclein zf-H2C2_2 PF13465.4 001013547.1_16124001_1 - 3.5e-71 232.5 74.6 2e-10 40.5 0.6 11.3 11 0 0 11 11 11 10 Zinc-finger double domain zf-C2H2 PF00096.24 001013547.1_16124001_1 - 3.6e-46 153.0 84.8 9.6e-07 28.8 1.1 10.5 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001013547.1_16124001_1 - 1.4e-34 115.6 77.5 0.00023 21.6 0.7 10.7 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001013547.1_16124001_1 - 2.8e-14 52.4 63.8 0.00039 20.0 0.6 10.1 10 0 0 10 10 10 6 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 001013547.1_16124001_1 - 2.3e-10 40.4 33.5 0.0018 18.4 0.4 8.5 10 0 0 10 10 9 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001013547.1_16124001_1 - 2.8e-09 36.6 64.5 0.039 13.8 0.3 10.8 11 0 0 11 11 11 5 C2H2-type zinc finger zf-H2C2_5 PF13909.4 001013547.1_16124001_1 - 2.7e-07 30.1 83.4 0.0037 16.8 4.0 12.0 11 3 0 11 11 11 6 C2H2-type zinc-finger domain zf-C2HE PF16278.3 001013547.1_16124001_1 - 5.5e-07 29.8 64.2 0.001 19.3 2.4 9.8 2 2 8 10 10 10 3 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.5 001013547.1_16124001_1 - 5.5e-05 23.3 70.6 0.058 13.7 2.7 10.6 11 0 0 11 11 11 5 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.4 001013547.1_16124001_1 - 8.3e-05 22.2 38.5 0.55 10.1 2.0 9.5 10 0 0 10 10 9 3 zinc-finger of a C2HC-type GAGA PF09237.9 001013547.1_16124001_1 - 0.00012 21.6 16.4 2.7 7.7 0.0 7.1 3 1 5 8 8 8 2 GAGA factor zf-LYAR PF08790.9 001013547.1_16124001_1 - 0.00056 19.6 45.9 0.019 14.7 0.6 9.7 10 0 0 10 10 10 3 LYAR-type C2HC zinc finger Zn-ribbon_8 PF09723.8 001013547.1_16124001_1 - 0.00065 19.6 38.2 0.14 12.1 1.8 7.1 4 2 5 9 9 9 4 Zinc ribbon domain FYDLN_acid PF09538.8 001013547.1_16124001_1 - 0.002 18.6 20.1 5.8 7.5 0.7 7.5 4 1 3 7 7 7 1 Protein of unknown function (FYDLN_acid) zinc_ribbon_9 PF14369.4 001013547.1_16124001_1 - 0.0023 18.0 27.0 6.5 7.0 0.0 8.7 9 1 0 9 9 9 1 zinc-ribbon zinc_ribbon_15 PF17032.3 001013547.1_16124001_1 - 0.004 17.7 34.0 0.1 13.2 1.8 5.8 2 2 2 5 5 5 2 zinc-ribbon family zf-RING_7 PF02591.13 001013547.1_16124001_1 - 0.015 15.3 18.8 11 6.2 0.0 7.6 7 1 0 7 7 7 0 C4-type zinc ribbon domain zf-AN1 PF01428.14 001013547.1_16124001_1 - 0.018 15.1 40.4 11 6.1 0.2 9.5 9 0 0 9 9 9 0 AN1-like Zinc finger ADK_lid PF05191.12 001013547.1_16124001_1 - 0.04 13.8 25.4 0.42 10.6 0.5 5.5 4 3 1 5 5 5 0 Adenylate kinase, active site lid BolA PF01722.16 001013547.1_16124001_1 - 0.067 13.4 11.6 2 8.7 0.2 4.6 2 1 2 4 4 4 0 BolA-like protein zf-Di19 PF05605.10 001013547.1_16124001_1 - 0.33 11.1 47.6 0.25 11.5 2.9 6.7 2 2 3 7 7 7 0 Drought induced 19 protein (Di19), zinc-binding C1_4 PF07975.10 001013547.1_16124001_1 - 0.76 10.0 42.6 0.21 11.8 1.9 6.1 3 2 4 7 7 7 0 TFIIH C1-like domain zf-C2H2_2 PF12756.5 001013547.1_16124001_1 - 1.5 9.1 52.8 0.8 9.9 1.3 9.2 1 1 6 8 8 8 0 C2H2 type zinc-finger (2 copies) zf-trcl PF13451.4 001013547.1_16124001_1 - 1.7 8.5 36.4 3.7 7.4 0.2 8.6 8 1 0 8 8 8 0 Probable zinc-ribbon domain DUF3268 PF11672.6 001013547.1_16124001_1 - 2.3 8.5 24.9 0.73 10.0 0.6 5.4 3 1 5 8 8 8 0 zinc-finger-containing domain zf-H2C2_2 PF13465.4 001013547.1_16124001_2 - 0.039 14.3 1.5 0.077 13.4 1.5 1.5 1 0 0 1 1 1 0 Zinc-finger double domain zf-C2H2 PF00096.24 001013547.1_16124001_2 - 0.12 12.8 0.6 0.33 11.4 0.6 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type UPF0183 PF03676.12 001082813.1_16123001_1 - 7.1e-163 542.3 0.1 8e-163 542.1 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0183) Rot1 PF10681.7 001082813.1_16123001_1 - 0.07 12.5 0.1 1.8 7.9 0.0 2.3 1 1 1 2 2 2 0 Chaperone for protein-folding within the ER, fungal Nucleoside_tran PF01733.16 001030177.1_16124001_1 - 1.2e-113 379.4 10.5 2.4e-113 378.5 10.5 1.5 1 0 0 1 1 1 1 Nucleoside transporter Mito_carr PF00153.25 001030237.1_16124001_1 - 1.1e-63 211.0 4.0 3.3e-22 78.1 0.0 3.4 2 1 1 3 3 3 3 Mitochondrial carrier protein Abi_HHR PF07815.12 001076707.1_16125001_3 - 2.7e-34 117.0 0.2 5.6e-34 116.0 0.2 1.5 1 0 0 1 1 1 1 Abl-interactor HHR SH3_1 PF00018.26 001076707.1_16125001_3 - 9.2e-16 57.1 0.1 1.6e-15 56.3 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001076707.1_16125001_3 - 1.8e-15 56.4 0.1 3.3e-15 55.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001076707.1_16125001_3 - 2e-09 36.9 0.1 3.4e-09 36.1 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain RhoGEF PF00621.18 001003883.1_16127001_2 - 7.1e-40 137.0 0.2 1.3e-39 136.2 0.2 1.4 1 0 0 1 1 1 1 RhoGEF domain PTCB-BRCT PF12738.5 001003883.1_16127001_2 - 1.6e-24 85.5 1.3 9.2e-18 63.8 0.0 3.4 3 0 0 3 3 3 2 twin BRCT domain BRCT PF00533.24 001003883.1_16127001_2 - 6.1e-18 64.9 0.1 1.9e-09 37.7 0.0 3.0 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 001003883.1_16127001_2 - 9.3e-06 25.8 0.0 0.13 12.6 0.0 3.1 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.3 001003883.1_16127001_2 - 0.00097 19.3 0.0 1.6 8.9 0.0 2.6 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain AT_hook PF02178.17 001003883.1_16127001_3 - 5.3 7.1 6.8 49 4.2 0.0 3.8 3 0 0 3 3 3 0 AT hook motif Serinc PF03348.13 199727.1_16125001_3 - 2.2e-174 580.3 14.0 2.7e-174 580.0 14.0 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) RhoGEF PF00621.18 131556.2_16128001_2 - 1e-45 156.1 0.1 2.4e-45 154.9 0.1 1.7 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 131556.2_16128001_2 - 1.3e-11 44.8 0.0 4.7e-11 43.0 0.0 2.1 1 0 0 1 1 1 1 PH domain FYVE PF01363.19 131556.2_16128001_2 - 7.4e-09 35.5 13.6 7.4e-09 35.5 13.6 2.6 2 0 0 2 2 2 1 FYVE zinc finger FYVE_2 PF02318.14 131556.2_16128001_2 - 0.006 16.7 9.6 0.006 16.7 9.6 2.5 2 0 0 2 2 2 1 FYVE-type zinc finger PH_6 PF15406.4 131556.2_16128001_2 - 0.037 14.2 0.0 0.14 12.4 0.0 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain EF-hand_2 PF09068.9 001080581.1_16125001_1 - 1.4e-33 115.5 3.0 4e-33 114.0 3.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_3 PF09069.9 001080581.1_16125001_1 - 1.3e-30 105.5 0.5 2.1e-29 101.6 0.0 3.0 3 0 0 3 3 3 1 EF-hand ZZ PF00569.15 001080581.1_16125001_1 - 1.3e-10 40.7 8.9 4.9e-10 38.9 8.9 1.9 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.14 001080581.1_16125001_1 - 0.00071 19.7 6.9 0.0016 18.6 6.9 1.6 1 0 0 1 1 1 1 C1 domain DUF342 PF03961.11 001080581.1_16125001_1 - 0.024 13.1 5.7 0.038 12.5 5.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) CRISPR_Cse2 PF09485.8 001080581.1_16125001_1 - 0.036 14.5 1.7 0.087 13.2 1.7 1.7 1 0 0 1 1 1 0 CRISPR-associated protein Cse2 (CRISPR_cse2) Seryl_tRNA_N PF02403.20 001080581.1_16125001_1 - 0.066 13.3 11.4 0.078 13.1 8.9 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Spore_III_AE PF09546.8 001080581.1_16125001_1 - 0.067 12.3 0.3 0.098 11.7 0.3 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AE (spore_III_AE) RICH PF05062.10 001080581.1_16125001_1 - 0.22 11.8 4.1 6.2 7.1 1.6 2.9 2 1 0 2 2 2 0 RICH domain IncA PF04156.12 001080581.1_16125001_1 - 0.29 10.8 14.6 0.62 9.7 14.6 1.4 1 0 0 1 1 1 0 IncA protein FUSC PF04632.10 001080581.1_16125001_1 - 0.82 8.0 4.3 1.2 7.4 4.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family OmpH PF03938.12 001080581.1_16125001_1 - 1.3 8.9 11.3 36 4.2 13.4 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Shugoshin_N PF07558.9 001080581.1_16125001_1 - 1.9 8.3 9.5 0.5 10.2 4.9 2.3 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Tnp_zf-ribbon_2 PF13842.4 001080581.1_16125001_1 - 3.1 8.5 9.8 7.9 7.2 9.8 1.7 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon APG6 PF04111.10 001080581.1_16125001_1 - 4.3 6.5 11.9 11 5.1 11.9 1.7 1 0 0 1 1 1 0 Autophagy protein Apg6 MACPF PF01823.17 001003496.1_16124001_2 - 1.1e-48 166.0 1.8 1.7e-48 165.4 1.8 1.3 1 0 0 1 1 1 1 MAC/Perforin domain Ldl_recept_a PF00057.16 001003496.1_16124001_2 - 7.9e-07 29.1 7.5 7.9e-07 29.1 7.5 3.1 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A TSP_1 PF00090.17 001003496.1_16124001_2 - 0.0011 19.0 10.1 0.0011 19.0 10.1 3.7 3 0 0 3 3 3 2 Thrombospondin type 1 domain T2SSM PF04612.10 001002671.1_16123001_3 - 0.11 12.4 0.2 0.17 11.8 0.2 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M zf-RING_10 PF16685.3 001163313.1_16126001_3 - 1.3e-31 108.4 14.7 1.3e-31 108.4 14.7 3.6 3 0 0 3 3 3 1 zinc RING finger of MSL2 MSL2-CXC PF16682.3 001163313.1_16126001_3 - 1.8e-18 66.3 20.5 1.8e-18 66.3 20.5 3.2 3 0 0 3 3 3 1 CXC domain of E3 ubiquitin-protein ligase MSL2 MIR PF02815.17 200039.1_16125001_2 - 1.1e-10 41.6 1.4 5.7e-10 39.2 1.4 2.0 1 1 0 1 1 1 1 MIR domain PX PF00787.22 001145894.1_16128001_3 - 5.9e-24 84.1 0.0 1.2e-23 83.1 0.0 1.5 1 0 0 1 1 1 1 PX domain EPTP PF03736.15 001039642.1_16124001_3 - 2.7e-56 187.2 19.3 1.9e-08 34.0 0.2 7.3 7 0 0 7 7 7 7 EPTP domain LRR_8 PF13855.4 001039642.1_16124001_3 - 2.1e-23 81.7 7.3 1.4e-13 50.2 1.2 3.2 3 1 1 4 4 4 2 Leucine rich repeat LRR_4 PF12799.5 001039642.1_16124001_3 - 2.4e-09 37.1 10.0 3e-05 24.1 0.1 3.3 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001039642.1_16124001_3 - 1.6e-08 34.5 0.5 4.8e-08 32.9 0.2 1.9 1 1 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001039642.1_16124001_3 - 0.00057 19.3 0.2 0.0013 18.2 0.2 1.6 1 0 0 1 1 1 1 Leucine-rich repeat LRRCT PF01463.22 001039642.1_16124001_3 - 0.0016 18.7 0.1 0.021 15.2 0.0 2.9 3 0 0 3 3 3 1 Leucine rich repeat C-terminal domain TPKR_C2 PF16920.3 001039642.1_16124001_3 - 0.076 13.0 0.3 0.25 11.4 0.3 1.9 1 0 0 1 1 1 0 Tyrosine-protein kinase receptor C2 Ig-like domain LRRNT PF01462.16 001039642.1_16124001_3 - 0.53 9.9 9.3 0.051 13.1 2.5 2.7 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 001039642.1_16124001_3 - 4.7 8.0 12.3 49 4.8 0.2 5.6 6 0 0 6 6 6 0 Leucine Rich Repeat DUF2184 PF09950.7 153652.2_16126001_1 - 0.22 10.8 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2184) zf-H2C2_2 PF13465.4 153652.2_16126001_3 - 3.6e-17 61.8 55.4 0.00078 19.7 0.2 7.8 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 153652.2_16126001_3 - 4e-17 61.5 63.1 0.0039 17.4 5.1 7.9 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 153652.2_16126001_3 - 6.9e-10 38.8 91.5 0.004 17.7 1.8 8.6 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 153652.2_16126001_3 - 0.0023 17.7 53.2 0.019 14.8 0.8 7.6 7 0 0 7 7 7 4 C2H2-type zinc finger Acyltransf_C PF16076.3 153652.2_16126001_3 - 0.099 12.7 2.5 8.4 6.5 0.6 2.7 2 0 0 2 2 2 0 Acyltransferase C-terminus zf-C2H2_11 PF16622.3 153652.2_16126001_3 - 0.13 11.9 0.1 0.13 11.9 0.1 6.3 7 0 0 7 7 7 0 zinc-finger C2H2-type zf-met PF12874.5 153652.2_16126001_3 - 0.15 12.4 27.8 2.5 8.5 0.5 5.5 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 153652.2_16126001_3 - 1.1 9.6 36.8 0.43 10.8 0.6 6.7 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding ADK_lid PF05191.12 153652.2_16126001_3 - 1.1 9.2 12.4 10 6.1 1.1 4.1 4 1 0 4 4 4 0 Adenylate kinase, active site lid zf-LITAF-like PF10601.7 153652.2_16126001_3 - 2 8.6 11.1 0.087 13.0 1.0 3.3 3 1 0 3 3 3 0 LITAF-like zinc ribbon domain ELM2 PF01448.22 001326392.1_16129001_2 - 1.3e-09 38.5 0.0 2.9e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 ELM2 domain Myb_DNA-binding PF00249.29 001326392.1_16129001_2 - 8.4e-05 22.5 0.3 0.0002 21.3 0.3 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain PH PF00169.27 001327809.1_16125001_1 - 1.4e-13 51.1 0.3 4.1e-13 49.6 0.3 1.9 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 001327809.1_16125001_1 - 0.0092 16.3 5.5 0.011 15.9 1.2 3.1 2 1 0 2 2 2 1 Pleckstrin homology domain DUF722 PF05263.9 001327809.1_16125001_1 - 0.32 11.1 5.0 6.7 6.8 0.4 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF722) DUF2576 PF10845.6 001327809.1_16125001_1 - 0.34 10.4 4.9 0.86 9.1 0.2 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2576) HALZ PF02183.16 001327809.1_16125001_1 - 0.36 10.9 12.3 1.7 8.8 0.0 4.8 5 0 0 5 5 5 0 Homeobox associated leucine zipper ATG16 PF08614.9 001327809.1_16125001_1 - 7.3 6.6 53.6 0.8 9.7 28.5 3.4 3 1 0 3 3 3 0 Autophagy protein 16 (ATG16) Pkinase PF00069.23 001099985.4_16129001_2 - 7.4e-51 172.9 0.0 1.4e-50 172.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001099985.4_16129001_2 - 7.6e-24 84.3 0.0 1.2e-23 83.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001099985.4_16129001_2 - 2.2e-05 23.8 0.0 4e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001099985.4_16129001_2 - 0.015 15.1 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.9 001099985.4_16129001_2 - 0.022 13.6 0.1 0.034 13.0 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Ras PF00071.20 001045350.1_16122001_2 - 4.4e-57 192.1 0.0 5.4e-57 191.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001045350.1_16122001_2 - 3.4e-23 82.0 0.0 4.8e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001045350.1_16122001_2 - 8.1e-10 38.3 0.0 1.5e-09 37.5 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001045350.1_16122001_2 - 0.0058 16.1 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001045350.1_16122001_2 - 0.019 14.2 0.0 0.028 13.6 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001045350.1_16122001_2 - 0.042 13.1 0.0 0.069 12.4 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit RGS PF00615.17 001017846.1_16123001_1 - 7.7e-34 116.4 0.8 1.3e-33 115.6 0.8 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.9 001017846.1_16123001_1 - 0.011 15.3 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain UBX PF00789.18 001024412.1_16123001_2 - 1.5e-07 31.4 0.0 2.7e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 UBX domain SPRY PF00622.26 001003474.1_16123001_3 - 1.9e-16 60.1 0.0 3.1e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 SPRY domain SOCS_box PF07525.14 001003474.1_16123001_3 - 2.7e-10 40.3 4.5 2.7e-10 40.3 4.5 1.7 2 0 0 2 2 2 1 SOCS box BASP1 PF05466.10 001202454.1_16123001_2 - 5.1e-21 75.7 72.2 5.1e-21 75.7 72.2 2.4 2 1 1 3 3 3 2 Brain acid soluble protein 1 (BASP1 protein) zf-C3HC4_4 PF15227.4 001328104.1_16125001_2 - 4.2e-11 42.7 9.8 4.2e-11 42.7 9.8 3.6 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001328104.1_16125001_2 - 1.2e-07 31.3 9.7 1.2e-07 31.3 9.7 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001328104.1_16125001_2 - 5e-07 29.3 10.8 5e-07 29.3 10.8 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001328104.1_16125001_2 - 1.5e-06 28.0 6.3 1.5e-06 28.0 6.3 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 001328104.1_16125001_2 - 0.00051 19.7 8.7 0.00051 19.7 8.7 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001328104.1_16125001_2 - 0.0008 19.5 9.7 0.0008 19.5 9.7 3.1 3 0 0 3 3 2 1 Ring finger domain BUD22 PF09073.8 001328104.1_16125001_2 - 0.0035 16.6 28.9 0.0061 15.8 28.9 1.3 1 0 0 1 1 1 1 BUD22 zf-RING_5 PF14634.4 001328104.1_16125001_2 - 0.011 15.6 9.7 0.011 15.6 9.7 3.7 3 0 0 3 3 3 0 zinc-RING finger domain Mpp10 PF04006.10 001328104.1_16125001_2 - 0.085 11.2 28.6 0.13 10.5 28.6 1.3 1 0 0 1 1 1 0 Mpp10 protein DDHD PF02862.15 001328104.1_16125001_2 - 0.27 11.2 5.9 0.26 11.3 3.5 2.0 2 0 0 2 2 2 0 DDHD domain zf-RING_10 PF16685.3 001328104.1_16125001_2 - 0.85 9.7 19.6 0.061 13.3 4.7 3.3 3 0 0 3 3 3 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.4 001328104.1_16125001_2 - 6.7 6.5 20.8 0.027 14.2 8.7 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Pkinase_Tyr PF07714.15 001006660.1_16129001_1 - 8.6e-88 293.8 0.0 1.5e-87 293.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase MAM PF00629.21 001006660.1_16129001_1 - 9.6e-43 145.7 1.9 5.3e-26 91.3 0.0 2.5 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu Pkinase PF00069.23 001006660.1_16129001_1 - 2.7e-32 112.0 0.0 4.1e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Gly_rich PF12810.5 001006660.1_16129001_1 - 4.8e-18 65.8 27.4 8.8e-18 65.0 27.4 1.3 1 0 0 1 1 1 1 Glycine rich protein Ldl_recept_a PF00057.16 001006660.1_16129001_1 - 9.9e-06 25.5 9.5 3.2e-05 23.9 9.5 2.0 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A AdoHcyase PF05221.15 001080649.2_16124001_2 - 4.7e-119 396.8 0.0 1.1e-63 215.0 0.2 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.19 001080649.2_16124001_2 - 1.9e-73 245.8 3.3 2.9e-73 245.1 3.3 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.17 001080649.2_16124001_2 - 4.8e-08 32.4 0.1 8.7e-08 31.6 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.17 001080649.2_16124001_2 - 0.00022 20.4 2.2 0.00063 19.0 2.2 1.7 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain IlvN PF07991.10 001080649.2_16124001_2 - 0.00034 20.1 0.0 0.001 18.5 0.1 1.8 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain FSIP1 PF15554.4 001080649.2_16124001_2 - 0.0019 17.3 0.3 0.0027 16.7 0.3 1.1 1 0 0 1 1 1 1 FSIP1 family Shikimate_DH PF01488.18 001080649.2_16124001_2 - 0.0045 16.9 0.1 0.012 15.5 0.1 1.7 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.4 001080649.2_16124001_2 - 0.013 15.8 0.9 0.043 14.1 0.4 2.1 3 0 0 3 3 3 0 Putative NAD(P)-binding Glu_dehyd_C PF16912.3 001080649.2_16124001_2 - 0.035 13.5 0.1 0.063 12.6 0.1 1.4 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus TrkA_N PF02254.16 001080649.2_16124001_2 - 0.05 13.7 0.3 0.19 11.8 0.3 2.1 1 1 0 1 1 1 0 TrkA-N domain SR-25 PF10500.7 001080649.2_16124001_2 - 0.069 12.6 1.7 0.1 12.1 1.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NAD_binding_2 PF03446.13 001080649.2_16124001_2 - 0.092 12.8 0.5 0.21 11.6 0.5 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.19 001080649.2_16124001_2 - 0.42 9.7 3.1 1.3 8.2 3.1 1.7 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain PTN_MK_N PF05196.11 131716.1_16123001_1 - 1.1e-27 95.8 17.4 1.1e-27 95.8 17.4 2.2 2 1 0 2 2 2 1 PTN/MK heparin-binding protein family, N-terminal domain PTN_MK_C PF01091.16 131716.1_16123001_1 - 1.4e-25 89.3 9.2 1.4e-25 89.3 9.2 2.8 3 0 0 3 3 3 1 PTN/MK heparin-binding protein family, C-terminal domain PDZ PF00595.22 001004018.1_16123001_1 - 1.3e-08 35.0 0.1 2.6e-08 34.0 0.1 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Ub-Mut7C PF14451.4 001004018.1_16123001_1 - 0.012 15.2 0.0 0.05 13.3 0.0 1.9 2 0 0 2 2 2 0 Mut7-C ubiquitin CDC37_M PF08565.9 201038.1_16124001_3 - 5.9e-29 100.3 1.3 9.8e-29 99.6 0.7 1.7 1 1 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.8 201038.1_16124001_3 - 1.9e-18 66.3 0.7 1.9e-18 66.3 0.7 3.7 3 2 1 4 4 4 1 Cdc37 C terminal domain CDC37_N PF03234.12 201038.1_16124001_3 - 1.6e-11 45.1 18.2 1.6e-11 45.1 18.2 3.1 1 1 1 3 3 3 1 Cdc37 N terminal kinase binding Caldesmon PF02029.13 201038.1_16124001_3 - 0.022 13.4 31.6 0.12 11.0 4.0 2.1 2 0 0 2 2 2 0 Caldesmon DUF123 PF01986.14 201038.1_16124001_3 - 0.21 12.0 5.9 0.085 13.2 2.0 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF123 GIT_CC PF16559.3 201038.1_16124001_3 - 1.5 8.8 8.4 2.9 7.9 3.6 2.5 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4407 PF14362.4 201038.1_16124001_3 - 2.3 7.4 9.0 0.29 10.3 2.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) SET PF00856.26 201038.1_16124001_3 - 5.7 7.2 9.8 22 5.3 9.8 2.0 1 1 0 1 1 1 0 SET domain PMP22_Claudin PF00822.18 001256207.1_16127001_2 - 8.7e-13 48.3 12.4 2.3e-12 47.0 12.4 1.7 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family DUF2207 PF09972.7 001256207.1_16127001_2 - 0.51 8.9 4.5 0.88 8.1 4.5 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Integrin_alpha2 PF08441.10 001190309.1_16128001_1 - 4.3e-83 279.6 1.5 5.4e-83 279.3 1.5 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 001190309.1_16128001_1 - 1.3e-21 76.3 15.4 1.2e-08 34.8 1.4 3.8 3 0 0 3 3 3 3 FG-GAP repeat VCBS PF13517.4 001190309.1_16128001_1 - 1.7e-12 47.6 8.4 7.6e-09 35.9 1.2 3.9 2 1 2 4 4 4 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.4 001190309.1_16128001_1 - 4.3e-05 23.6 4.6 1.5 9.0 0.2 4.4 4 0 0 4 4 4 2 FG-GAP repeat Collectrin PF16959.3 001190309.1_16128001_1 - 0.00074 19.1 0.0 0.0017 18.0 0.0 1.5 1 0 0 1 1 1 1 Renal amino acid transporter Neisseria_PilC PF05567.9 001190309.1_16128001_1 - 0.002 17.1 0.9 0.0033 16.3 0.9 1.2 1 0 0 1 1 1 1 Neisseria PilC beta-propeller domain LYRIC PF15686.3 001190309.1_16128001_1 - 0.061 12.7 0.0 0.061 12.7 0.0 1.9 2 0 0 2 2 2 0 Lysine-rich CEACAM1 co-isolated protein family fn3 PF00041.19 001312916.1_16129001_2 - 1.4e-131 429.0 14.1 4.2e-16 58.9 0.1 10.4 10 0 0 10 10 10 10 Fibronectin type III domain Fibrinogen_C PF00147.16 001312916.1_16129001_2 - 3.9e-82 275.2 5.0 6.1e-82 274.6 5.0 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_2 PF07974.11 001312916.1_16129001_2 - 7e-55 182.9 344.3 0.00012 22.2 13.5 17.6 17 0 0 17 17 17 16 EGF-like domain EGF PF00008.25 001312916.1_16129001_2 - 1.1e-18 67.1 299.9 0.0023 18.1 11.4 17.7 17 0 0 17 17 17 15 EGF-like domain Pur_ac_phosph_N PF16656.3 001312916.1_16129001_2 - 5.5e-13 49.2 10.4 0.13 12.7 0.0 9.2 7 3 0 7 7 7 4 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 001312916.1_16129001_2 - 4e-10 39.9 0.1 1.7 9.1 0.0 7.9 8 0 0 8 8 8 1 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 001312916.1_16129001_2 - 4.6e-06 26.8 0.0 5.8 7.2 0.0 6.2 6 0 0 6 6 6 1 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.3 001312916.1_16129001_2 - 1.4e-05 25.0 0.6 0.14 12.2 0.0 6.1 7 2 0 7 7 7 1 Fibronectin type III domain Actin PF00022.17 001312916.1_16129001_2 - 0.00017 20.2 14.3 0.99 7.8 0.1 8.6 8 2 3 11 11 11 1 Actin hEGF PF12661.5 001312916.1_16129001_2 - 0.00046 20.6 234.4 0.11 13.1 4.0 18.0 17 0 0 17 17 17 10 Human growth factor-like EGF Big_5 PF13205.4 001312916.1_16129001_2 - 0.0023 18.5 10.1 0.13 12.8 1.1 5.1 5 0 0 5 5 5 1 Bacterial Ig-like domain DUF4945 PF16303.3 001312916.1_16129001_2 - 0.0054 16.5 1.2 15 5.4 0.0 4.4 5 0 0 5 5 5 0 Domain of unknown function (DUF4945) REJ PF02010.13 001312916.1_16129001_2 - 0.023 13.4 0.2 4.2 5.9 0.0 3.2 3 0 0 3 3 3 0 REJ domain Glyco_hydro_66 PF13199.4 001312916.1_16129001_2 - 0.032 12.8 0.0 1.8 7.0 0.0 2.9 3 0 0 3 3 3 0 Glycosyl hydrolase family 66 Cyt-b5 PF00173.26 001037704.2_16123001_1 - 3.2e-11 43.1 0.1 4.9e-11 42.5 0.1 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TPR_12 PF13424.4 001328155.1_16124001_1 - 9.9e-18 64.1 19.1 3e-07 30.5 0.3 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.4 001328155.1_16124001_1 - 2.9e-12 45.7 20.0 3.5e-05 23.5 0.1 6.2 5 1 2 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.15 001328155.1_16124001_1 - 5.3e-12 44.8 18.1 0.00023 20.9 0.3 6.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.26 001328155.1_16124001_1 - 5.2e-11 41.7 14.6 1.1e-05 25.0 0.2 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.5 001328155.1_16124001_1 - 1.4e-05 25.1 10.1 0.00063 19.8 1.1 4.3 2 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.4 001328155.1_16124001_1 - 5e-05 22.9 10.3 0.00032 20.4 0.1 5.1 4 1 2 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.4 001328155.1_16124001_1 - 6.2e-05 23.5 10.6 2.9 8.5 0.2 5.0 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.4 001328155.1_16124001_1 - 0.00044 20.7 15.1 8.9 7.3 0.0 6.9 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.4 001328155.1_16124001_1 - 0.0026 18.2 17.1 1.7 9.4 0.3 5.8 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_19 PF14559.4 001328155.1_16124001_1 - 0.025 14.9 13.2 2.9 8.3 2.1 4.8 3 1 2 5 5 5 0 Tetratricopeptide repeat TFR_dimer PF04253.13 001328155.1_16124001_1 - 0.058 13.4 0.0 0.2 11.6 0.0 2.0 2 1 0 2 2 2 0 Transferrin receptor-like dimerisation domain TPR_7 PF13176.4 001328155.1_16124001_1 - 0.16 11.9 11.4 3.8 7.6 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat RPN7 PF10602.7 001328155.1_16124001_1 - 0.24 10.9 7.2 0.11 12.0 0.2 3.3 2 2 2 4 4 4 0 26S proteasome subunit RPN7 TPR_17 PF13431.4 001328155.1_16124001_1 - 0.3 11.4 8.2 1.3 9.4 0.0 4.5 6 0 0 6 6 4 0 Tetratricopeptide repeat DUF2802 PF10975.6 001328155.1_16124001_1 - 0.7 9.9 4.3 0.45 10.5 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) TPR_11 PF13414.4 001328155.1_16124001_1 - 0.99 9.0 11.8 16 5.2 0.1 5.2 4 1 1 5 5 5 0 TPR repeat OAD_gamma PF04277.11 001004652.3_16122001_1 - 0.25 11.8 0.8 0.38 11.2 0.8 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain COX17 PF05051.11 001004652.3_16122001_2 - 5.1e-21 74.6 6.2 5.1e-21 74.6 6.2 2.2 2 0 0 2 2 2 1 Cytochrome C oxidase copper chaperone (COX17) Arf PF00025.19 200818.1_16124001_1 - 5.3e-34 117.1 0.0 8.4e-34 116.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 200818.1_16124001_1 - 5.2e-06 25.9 0.0 1.2e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 200818.1_16124001_1 - 3.2e-05 23.9 0.0 6.5e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.11 200818.1_16124001_1 - 0.0033 17.5 0.0 0.016 15.3 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 200818.1_16124001_1 - 0.016 14.6 0.0 0.048 13.1 0.0 1.8 1 1 0 1 1 1 0 Ras family EF-hand_7 PF13499.4 001044860.1_16122001_3 - 6.9e-22 77.6 8.3 1.3e-11 44.6 1.4 2.6 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.30 001044860.1_16122001_3 - 5.6e-19 66.1 4.0 7.7e-07 28.1 0.2 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.4 001044860.1_16122001_3 - 4e-17 60.5 0.6 2.2e-06 27.0 0.0 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.4 001044860.1_16122001_3 - 1.4e-16 59.0 0.1 2.2e-05 23.6 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 001044860.1_16122001_3 - 8.2e-10 38.2 10.1 0.05 13.3 0.2 4.5 4 1 0 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001044860.1_16122001_3 - 0.01 16.0 0.8 3 8.1 0.1 3.2 2 2 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region zf-CCCH_2 PF14608.4 001161671.1_16128001_1 - 0.031 14.6 10.3 0.83 10.1 1.4 3.5 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Mit_proteolip PF08039.9 001161671.1_16128001_2 - 0.23 11.6 15.1 0.081 13.1 5.8 2.6 2 0 0 2 2 2 0 Mitochondrial proteolipid Mit_proteolip PF08039.9 001161671.1_16128001_3 - 2.6 8.3 18.7 0.2 11.9 3.9 2.5 2 0 0 2 2 2 0 Mitochondrial proteolipid Ribosomal_S18 PF01084.18 001017759.2_16123001_1 - 4.6e-16 58.6 0.1 1.4e-15 57.1 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S18 TPR_10 PF13374.4 001077178.2_16124001_3 - 2e-52 173.6 10.3 3.1e-16 58.5 0.0 5.7 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_12 PF13424.4 001077178.2_16124001_3 - 7.5e-49 163.8 18.8 5.9e-20 71.2 1.3 3.8 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.4 001077178.2_16124001_3 - 4e-27 92.1 17.5 5.4e-06 25.9 0.5 6.1 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.26 001077178.2_16124001_3 - 1.3e-24 84.8 27.2 1.5e-07 30.7 0.5 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.15 001077178.2_16124001_3 - 2.4e-17 61.4 24.9 0.00077 19.3 0.4 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.4 001077178.2_16124001_3 - 9.4e-15 53.4 19.6 0.0017 18.3 0.1 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.4 001077178.2_16124001_3 - 1.1e-12 48.2 7.0 1.1e-05 25.7 0.5 3.7 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.4 001077178.2_16124001_3 - 4e-12 46.5 6.3 0.0013 19.2 0.1 4.8 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.4 001077178.2_16124001_3 - 6.6e-08 32.3 7.0 0.19 12.1 0.4 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.4 001077178.2_16124001_3 - 2.5e-07 30.8 12.9 2.7 8.9 0.3 6.1 3 1 3 6 6 5 1 Tetratricopeptide repeat ANAPC3 PF12895.5 001077178.2_16124001_3 - 7.4e-07 29.1 11.1 0.015 15.4 0.1 3.5 1 1 2 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.12 001077178.2_16124001_3 - 7.9e-05 22.8 0.8 24 5.8 0.0 6.1 7 0 0 7 7 5 0 Tetratricopeptide repeat PPR PF01535.18 001077178.2_16124001_3 - 0.0001 22.1 0.5 0.13 12.5 0.0 4.0 5 0 0 5 5 3 1 PPR repeat TMF_TATA_bd PF12325.6 001077178.2_16124001_3 - 0.012 15.7 9.6 0.012 15.7 9.6 3.1 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding SHNi-TPR PF10516.7 001077178.2_16124001_3 - 0.014 14.7 0.9 4.5 6.7 0.0 3.8 3 0 0 3 3 3 0 SHNi-TPR PPR_2 PF13041.4 001077178.2_16124001_3 - 0.02 15.0 0.8 2.3 8.3 0.0 3.3 3 0 0 3 3 3 0 PPR repeat family DUF627 PF04781.10 001077178.2_16124001_3 - 0.02 14.8 3.4 2.2 8.2 0.1 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF627) DUF4919 PF16266.3 001077178.2_16124001_3 - 0.089 12.6 1.0 0.81 9.5 0.1 2.9 1 1 1 3 3 3 0 Domain of unknown function (DUF4919) HALZ PF02183.16 001077178.2_16124001_3 - 0.092 12.8 5.9 0.17 12.0 1.0 3.5 2 1 1 3 3 3 0 Homeobox associated leucine zipper Wzy_C_2 PF11846.6 001077178.2_16124001_3 - 0.16 11.8 1.4 2.4 7.9 0.2 2.9 2 2 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal APG6 PF04111.10 001077178.2_16124001_3 - 0.21 10.8 11.9 0.4 9.9 11.9 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF2120 PF09893.7 001077178.2_16124001_3 - 0.26 11.2 1.9 0.81 9.7 0.4 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) JIP_LZII PF16471.3 001077178.2_16124001_3 - 0.65 10.1 10.4 0.35 11.0 3.6 2.6 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II RPN7 PF10602.7 001077178.2_16124001_3 - 1.3 8.5 8.8 2.6 7.5 0.6 3.9 2 1 2 4 4 4 0 26S proteasome subunit RPN7 TPR_6 PF13174.4 001077178.2_16124001_3 - 1.5 9.5 14.8 0.33 11.6 0.6 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_3 PF07720.10 001077178.2_16124001_3 - 1.9 8.4 13.6 0.44 10.5 1.5 4.2 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF972 PF06156.11 001077178.2_16124001_3 - 2.1 8.9 16.7 0.59 10.7 6.3 4.1 4 1 0 4 4 4 0 Protein of unknown function (DUF972) COG2 PF06148.9 001077178.2_16124001_3 - 2.3 8.2 12.8 0.2 11.6 5.6 2.7 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4404 PF14357.4 001077178.2_16124001_3 - 8.3 7.0 18.1 24 5.6 1.3 4.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4404) Lectin_C PF00059.19 001245035.1_16122001_1 - 6.3e-19 68.6 5.0 8.6e-19 68.1 5.0 1.2 1 0 0 1 1 1 1 Lectin C-type domain Fungus-induced PF10917.6 001245035.1_16122001_1 - 0.05 13.8 0.0 0.2 11.9 0.0 2.0 1 0 0 1 1 1 0 Fungus-induced protein Tubulin PF00091.23 001017762.2_16124001_3 - 3.9e-70 235.9 0.0 6e-70 235.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001017762.2_16124001_3 - 2e-40 137.8 0.0 3.3e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 001017762.2_16124001_3 - 2.1e-06 27.9 0.0 4.9e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.4 001017762.2_16124001_3 - 0.021 14.4 0.0 0.051 13.1 0.0 1.6 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.4 001017762.2_16124001_3 - 0.034 13.2 0.0 0.06 12.4 0.0 1.3 1 0 0 1 1 1 0 Tubulin like PDZ PF00595.22 001130659.1_16124001_3 - 4.7e-10 39.6 0.0 9.3e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PB1 PF00564.22 001130659.1_16124001_3 - 6.1e-10 38.7 0.0 1.1e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 PB1 domain PDZ_2 PF13180.4 001130659.1_16124001_3 - 0.029 14.6 0.0 0.064 13.4 0.0 1.5 1 0 0 1 1 1 0 PDZ domain TEA PF01285.16 212847.2_16124001_1 - 8.2e-25 87.7 0.0 1.3e-24 87.0 0.0 1.2 1 0 0 1 1 1 1 TEA/ATTS domain family zf-H2C2_2 PF13465.4 001082919.1_16124001_1 - 2.3e-41 138.3 65.9 7.4e-09 35.5 1.0 10.6 11 0 0 11 11 10 7 Zinc-finger double domain zf-C2H2 PF00096.24 001082919.1_16124001_1 - 3.8e-34 115.1 63.2 2e-05 24.6 1.8 9.4 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001082919.1_16124001_1 - 9.8e-23 78.7 66.0 0.00052 20.5 0.7 9.3 10 0 0 10 10 8 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001082919.1_16124001_1 - 1.6e-17 62.8 51.3 0.00029 20.6 0.8 8.4 8 0 0 8 8 8 7 C2H2-type zinc finger zf-met PF12874.5 001082919.1_16124001_1 - 2e-09 37.4 57.6 0.0034 17.6 0.8 8.6 10 0 0 10 10 8 6 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001082919.1_16124001_1 - 4e-09 36.4 40.7 0.0073 16.5 0.2 9.2 9 0 0 9 9 8 4 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 001082919.1_16124001_1 - 1.1e-07 31.3 47.7 0.00018 21.1 0.4 7.9 8 0 0 8 8 8 4 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 001082919.1_16124001_1 - 3e-05 24.6 27.3 0.093 13.4 1.3 4.5 3 1 1 4 4 4 3 zinc-ribbon family C1_1 PF00130.20 001082919.1_16124001_1 - 5e-05 23.0 34.0 0.25 11.1 0.7 6.6 3 1 3 6 6 6 3 Phorbol esters/diacylglycerol binding domain (C1 domain) BolA PF01722.16 001082919.1_16124001_1 - 0.022 14.9 4.7 4.3 7.5 0.1 4.5 3 1 2 5 5 5 0 BolA-like protein Zn-ribbon_8 PF09723.8 001082919.1_16124001_1 - 0.03 14.3 32.6 0.96 9.5 2.9 6.3 3 2 3 6 6 6 0 Zinc ribbon domain TerY_C PF15616.4 001082919.1_16124001_1 - 0.044 13.8 0.7 0.044 13.8 0.7 3.8 1 1 3 4 4 4 0 TerY-C metal binding domain zf-C2HE PF16278.3 001082919.1_16124001_1 - 0.057 13.8 39.4 0.23 11.8 0.3 7.5 3 3 3 6 6 5 0 C2HE / C2H2 / C2HC zinc-binding finger zf-trcl PF13451.4 001082919.1_16124001_1 - 0.15 11.9 33.3 13 5.7 0.1 7.9 7 1 0 7 7 7 0 Probable zinc-ribbon domain Ribosomal_L31 PF01197.16 001082919.1_16124001_1 - 0.2 11.8 9.0 5.3 7.2 1.2 4.3 2 2 2 4 4 4 0 Ribosomal protein L31 zf-C2HC_2 PF13913.4 001082919.1_16124001_1 - 0.61 9.9 35.7 1.4 8.8 0.4 7.8 7 0 0 7 7 7 0 zinc-finger of a C2HC-type ADK_lid PF05191.12 001082919.1_16124001_1 - 0.91 9.5 31.0 0.47 10.4 5.0 5.5 4 1 2 6 6 6 0 Adenylate kinase, active site lid DUF2256 PF10013.7 001082919.1_16124001_1 - 3.7 7.6 31.8 2.3 8.3 0.0 7.9 8 0 0 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2_2 PF12756.5 001082919.1_16124001_1 - 6.1 7.1 34.0 0.99 9.6 1.0 7.6 1 1 6 7 7 7 0 C2H2 type zinc-finger (2 copies) zf-AN1 PF01428.14 001082919.1_16124001_1 - 8.8 6.5 43.1 13 5.9 0.1 8.7 7 1 1 8 8 8 0 AN1-like Zinc finger ArfGap PF01412.16 001130663.1_16127001_1 - 2.9e-35 120.7 0.0 8.6e-35 119.1 0.0 1.9 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf BAR_3 PF16746.3 001130663.1_16127001_1 - 2.8e-28 99.1 12.3 4.7e-28 98.3 12.3 1.3 1 0 0 1 1 1 1 BAR domain of APPL family Ank_2 PF12796.5 001130663.1_16127001_1 - 8e-17 61.5 0.2 1.2e-08 35.3 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) BAR PF03114.16 001130663.1_16127001_1 - 4.6e-11 42.7 7.2 7.8e-11 41.9 7.2 1.3 1 0 0 1 1 1 1 BAR domain PH PF00169.27 001130663.1_16127001_1 - 6.4e-10 39.4 0.5 2.2e-09 37.7 0.5 2.0 1 0 0 1 1 1 1 PH domain SH3_9 PF14604.4 001130663.1_16127001_1 - 1.8e-09 37.2 0.1 3.7e-09 36.2 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001130663.1_16127001_1 - 1.8e-09 36.9 0.3 3.8e-09 35.9 0.3 1.6 1 0 0 1 1 1 1 SH3 domain Ank_4 PF13637.4 001130663.1_16127001_1 - 1.3e-08 35.0 0.8 6.4e-05 23.3 0.1 3.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_2 PF07653.15 001130663.1_16127001_1 - 1.4e-07 31.0 0.1 3e-07 29.9 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain Ank PF00023.28 001130663.1_16127001_1 - 3.8e-07 30.1 0.1 0.0022 18.2 0.0 3.9 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.4 001130663.1_16127001_1 - 3.7e-05 23.8 0.0 0.0021 18.2 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 001130663.1_16127001_1 - 9.1e-05 22.4 0.0 0.63 10.6 0.0 4.1 3 0 0 3 3 3 1 Ankyrin repeat PH_9 PF15410.4 001130663.1_16127001_1 - 0.054 13.7 1.4 5.1 7.4 0.1 3.1 3 1 0 3 3 3 0 Pleckstrin homology domain A2L_zn_ribbon PF08792.8 001130663.1_16127001_1 - 0.11 12.2 1.3 4 7.2 0.5 2.7 2 0 0 2 2 2 0 A2L zinc ribbon domain DUF305 PF03713.11 001130663.1_16127001_1 - 0.11 12.5 0.6 20 5.1 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF305) SKA1 PF07160.10 001130663.1_16127001_1 - 0.33 10.6 12.5 0.74 9.5 0.1 3.3 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 1 Fib_alpha PF08702.8 001130663.1_16127001_1 - 0.54 10.3 11.8 1.9 8.5 0.1 2.7 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4404 PF14357.4 001130663.1_16127001_1 - 1.4 9.5 14.7 0.54 10.8 5.7 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) BST2 PF16716.3 001130663.1_16127001_1 - 2 8.9 9.5 2.4 8.7 0.3 2.9 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 Sec1 PF00995.21 213471.1_16126001_2 - 1.2e-127 427.4 2.7 1.2e-127 427.4 2.7 1.3 2 0 0 2 2 2 1 Sec1 family TNF PF00229.16 131843.2_16126001_2 - 1.9e-37 127.9 0.9 3.9e-37 126.9 0.3 1.8 2 0 0 2 2 2 1 TNF(Tumour Necrosis Factor) family CBP_BcsF PF11120.6 001177453.2_16122001_1 - 0.78 9.7 4.6 0.79 9.7 1.8 2.4 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsF EF1_GNE PF00736.17 001177453.2_16122001_3 - 2e-37 127.1 1.7 5.2e-37 125.8 0.7 2.1 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.7 001177453.2_16122001_3 - 2.3e-09 37.4 5.3 2.3e-09 37.4 5.3 2.6 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region DUF3450 PF11932.6 001177453.2_16122001_3 - 0.015 14.5 1.8 0.027 13.6 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) LRR_9 PF14580.4 001177453.2_16122001_3 - 0.033 13.5 0.0 0.071 12.5 0.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeat SURF2 PF05477.9 001177453.2_16122001_3 - 0.045 13.1 4.2 0.095 12.1 4.2 1.3 1 1 0 1 1 1 0 Surfeit locus protein 2 (SURF2) CCD48 PF15799.3 001177453.2_16122001_3 - 0.053 11.8 3.7 0.088 11.1 3.8 1.3 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 48 MinC_N PF05209.11 001177453.2_16122001_3 - 0.065 13.1 0.2 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 Septum formation inhibitor MinC, N-terminal domain Ribosomal_60s PF00428.17 001177453.2_16122001_3 - 0.077 13.4 0.1 0.077 13.4 0.1 2.3 3 0 0 3 3 2 0 60s Acidic ribosomal protein ANAPC15 PF15243.4 001177453.2_16122001_3 - 0.078 13.3 4.2 1 9.7 2.1 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 Sigma70_ner PF04546.11 001177453.2_16122001_3 - 0.19 11.5 6.6 0.39 10.4 0.1 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region Striatin PF08232.10 001177453.2_16122001_3 - 2 8.9 6.6 3 8.3 6.6 1.2 1 0 0 1 1 1 0 Striatin family 2OG-FeII_Oxy_3 PF13640.4 001130772.1_16123001_1 - 2.6e-09 37.7 0.1 4.4e-09 37.0 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ammonium_transp PF00909.19 001126444.1_16124001_1 - 4.2e-63 213.3 14.8 5.7e-63 212.8 14.8 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family CPP1-like PF11833.6 001126444.1_16124001_1 - 5.8 6.4 5.6 2.1 7.8 0.2 2.9 2 1 1 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Peptidase_C1 PF00112.21 001002368.1_16123001_3 - 5.3e-87 291.4 4.1 5.7e-87 291.3 3.2 1.4 2 0 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 001002368.1_16123001_3 - 2.4e-12 46.9 0.3 5e-12 45.9 0.3 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 001002368.1_16123001_3 - 5.5e-06 25.3 0.7 0.011 14.4 0.2 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Voltage_CLC PF00654.18 001328709.1_16127001_1 - 4.4e-89 299.0 26.7 4.4e-89 299.0 26.7 2.0 1 1 1 2 2 2 1 Voltage gated chloride channel CBS PF00571.26 001328709.1_16127001_1 - 0.0042 17.4 0.2 0.2 12.0 0.0 2.6 2 0 0 2 2 2 1 CBS domain Pro-kuma_activ PF09286.9 001128798.1_16124001_2 - 1.1e-30 106.6 0.0 1.6e-29 102.9 0.0 2.4 3 0 0 3 3 3 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.20 001128798.1_16124001_2 - 4.6e-05 22.7 0.0 7.1e-05 22.1 0.0 1.4 1 1 0 1 1 1 1 Subtilase family Coiled-coil_56 PF09813.7 001204250.2_16122001_2 - 3.4e-17 62.2 0.2 4.8e-17 61.7 0.1 1.3 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 56 Nuc_recep-AF1 PF11825.6 001002481.2_16122001_1 - 0.0094 15.9 2.0 0.015 15.2 2.0 1.3 1 0 0 1 1 1 1 Nuclear/hormone receptor activator site AF-1 GST_N_3 PF13417.4 001002481.2_16122001_3 - 3.8e-15 55.9 0.0 6.9e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.18 001002481.2_16122001_3 - 4.5e-15 55.6 0.0 7.8e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 001002481.2_16122001_3 - 4.4e-11 42.8 0.0 7.4e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 001002481.2_16122001_3 - 1e-07 31.9 0.0 1.7e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 001002481.2_16122001_3 - 5.1e-07 29.7 0.0 7.7e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 001002481.2_16122001_3 - 0.0078 16.0 0.0 0.017 15.0 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Ank_4 PF13637.4 001037104.1_16122001_2 - 1.5e-13 50.8 0.0 3.9e-13 49.5 0.0 1.7 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.5 001037104.1_16122001_2 - 1.5e-11 44.6 0.0 5.1e-11 42.9 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001037104.1_16122001_2 - 2.6e-11 43.4 0.0 1.7e-06 28.1 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 001037104.1_16122001_2 - 5.4e-10 39.1 0.0 0.0023 18.2 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.4 001037104.1_16122001_2 - 1.5e-09 37.2 0.0 0.00047 20.3 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat V-SNARE_C PF12352.6 001017651.2_16123001_3 - 8.3e-20 70.7 2.8 8.3e-20 70.7 2.8 2.3 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.11 001017651.2_16123001_3 - 0.054 13.3 0.7 0.55 10.1 0.1 2.4 2 0 0 2 2 2 0 Sec20 Tfb4 PF03850.12 001128422.1_16123001_1 - 6.7e-101 337.2 1.7 8.3e-101 336.9 1.7 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 BolA PF01722.16 001243171.1_16122001_2 - 5.1e-19 68.2 0.1 7.8e-19 67.6 0.1 1.3 1 0 0 1 1 1 1 BolA-like protein MFS_1 PF07690.14 199584.1_16127001_1 - 3.6e-33 114.8 37.5 3.6e-33 114.8 37.5 2.8 3 1 0 3 3 3 1 Major Facilitator Superfamily Ribosomal_S6e PF01092.17 001003728.1_16122001_1 - 1.6e-68 228.3 1.3 2.4e-68 227.7 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S6e XK-related PF09815.7 001012257.2_16126001_3 - 2.7e-120 401.1 36.8 4.8e-120 400.3 36.8 1.4 1 0 0 1 1 1 1 XK-related protein ECF_trnsprt PF12822.5 001012257.2_16126001_3 - 0.81 9.6 5.1 2 8.3 5.1 1.6 1 0 0 1 1 1 0 ECF transporter, substrate-specific component Peptidase_M49 PF03571.13 001002683.1_16126001_1 - 2.9e-232 771.8 0.0 3.5e-232 771.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 DUF596 PF04591.10 001002683.1_16126001_1 - 0.13 12.3 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF596 DENN PF02141.19 001002327.1_16127001_1 - 2.5e-60 203.5 0.6 5.2e-60 202.5 0.6 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.16 001002327.1_16127001_1 - 4.1e-17 62.6 0.1 1.2e-16 61.1 0.1 1.9 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.17 001002327.1_16127001_1 - 5.6e-12 45.3 2.0 1.7e-11 43.8 2.0 1.9 1 0 0 1 1 1 1 dDENN domain SPA PF08616.8 001002327.1_16127001_1 - 0.087 12.6 0.3 0.17 11.7 0.3 1.4 1 0 0 1 1 1 0 Stabilization of polarity axis eIF_4EBP PF05456.9 199683.1_16123001_1 - 1.2e-45 154.0 0.1 1.2e-45 154.0 0.1 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) ETRAMP PF09716.8 199683.1_16123001_2 - 0.41 10.6 10.0 0.96 9.4 10.0 1.6 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Pkinase PF00069.23 001024379.1_16124001_1 - 2.8e-24 85.8 0.0 3.6e-24 85.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001024379.1_16124001_1 - 1.8e-13 50.2 0.0 2.2e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase CK1gamma_C PF12605.6 001024379.1_16124001_1 - 1.3e-12 48.6 7.3 3.6e-09 37.5 1.2 2.4 1 1 1 2 2 2 2 Casein kinase 1 gamma C terminal CD20 PF04103.13 001327805.1_16123001_3 - 2.4e-07 30.9 9.7 2.4e-07 30.9 9.7 1.9 2 0 0 2 2 2 1 CD20-like family COX7C PF02935.14 001327805.1_16123001_3 - 0.22 11.7 1.6 0.39 10.8 0.1 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIIc Ank_2 PF12796.5 001126433.2_16129001_2 - 8.4e-19 67.8 4.2 6.4e-10 39.4 0.4 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001126433.2_16129001_2 - 2.8e-17 62.4 1.1 4.2e-12 45.9 0.4 3.5 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 001126433.2_16129001_2 - 5.3e-15 55.4 0.4 1.2e-06 28.8 0.0 3.8 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Chromo PF00385.22 001126433.2_16129001_2 - 3.7e-14 52.2 2.4 1e-13 50.8 2.4 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Ank_3 PF13606.4 001126433.2_16129001_2 - 1.8e-11 43.0 1.0 4.3e-06 26.5 0.0 4.4 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.28 001126433.2_16129001_2 - 9.3e-09 35.2 4.4 2.3e-05 24.5 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Cadherin PF00028.15 212571.1_16128001_1 - 3.6e-87 286.8 3.5 4e-20 71.9 0.0 6.3 5 1 1 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 212571.1_16128001_1 - 2.3e-33 113.7 0.2 1e-30 105.2 0.1 4.2 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.3 212571.1_16128001_1 - 2.8e-24 85.6 0.7 9.4e-24 83.9 0.7 2.0 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal CTP_transf_like PF01467.24 001020735.1_16125001_3 - 5e-29 101.2 0.6 1e-28 100.2 0.0 1.7 2 0 0 2 2 2 1 Cytidylyltransferase-like Gp-FAR-1 PF05823.10 001020735.1_16125001_3 - 0.023 14.9 0.6 0.048 13.9 0.6 1.5 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Phtf-FEM1B_bdg PF12129.6 001002305.1_16123001_1 - 2e-68 228.9 0.3 3.5e-68 228.1 0.3 1.4 1 0 0 1 1 1 1 Male germ-cell putative homeodomain transcription factor C2 PF00168.28 001082842.1_16124001_1 - 8.5e-51 170.4 0.1 6e-25 87.4 0.0 2.6 2 0 0 2 2 2 2 C2 domain PI3K_C2 PF00792.22 001082842.1_16124001_1 - 4.9e-05 23.3 0.0 0.12 12.3 0.0 3.2 2 0 0 2 2 2 2 Phosphoinositide 3-kinase C2 CEP76-C2 PF15627.4 001082842.1_16124001_1 - 0.0015 17.9 0.1 0.07 12.6 0.2 2.8 3 1 0 3 3 3 1 CEP76 C2 domain DUF2975 PF11188.6 001082842.1_16124001_1 - 0.056 13.2 0.1 0.097 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) DUF1242 PF06842.10 001003761.2_16125001_2 - 6.8e-11 41.6 1.2 1.7e-10 40.4 1.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) Glycogen_syn PF05693.11 201180.2_16125001_1 - 0 1167.6 0.0 0 1167.3 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.18 201180.2_16125001_1 - 2e-05 24.1 0.1 0.00085 18.8 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.4 201180.2_16125001_1 - 2.1e-05 24.5 0.1 2.1e-05 24.5 0.1 1.8 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.4 201180.2_16125001_1 - 0.00013 22.3 0.1 0.016 15.5 0.0 2.7 3 0 0 3 3 3 1 Glycosyl transferases group 1 Ribosomal_L26 PF16906.3 213113.2_16122001_1 - 1.8e-44 150.0 6.3 2.9e-44 149.3 6.3 1.3 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.27 213113.2_16122001_1 - 1.2e-07 31.3 5.7 3e-07 30.0 5.7 1.8 1 1 0 1 1 1 1 KOW motif B56 PF01603.18 001044821.2_16126001_2 - 7.2e-200 664.1 10.7 8.7e-200 663.8 10.7 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Utp14 PF04615.11 001256628.1_16126001_2 - 1.5e-171 572.5 60.9 2.1e-171 572.0 60.9 1.2 1 0 0 1 1 1 1 Utp14 protein zf-3CxxC_2 PF17180.2 001098388.2_16129001_3 - 6.8e-25 87.4 10.3 1.9e-24 86.0 10.3 1.9 1 0 0 1 1 1 1 Zinc-binding domain zf-CCHC_2 PF13696.4 001098388.2_16129001_3 - 6.6e-11 41.7 6.4 2.9e-10 39.6 6.4 2.3 1 0 0 1 1 1 1 Zinc knuckle zf-3CxxC PF13695.4 001098388.2_16129001_3 - 0.0083 16.4 11.2 0.033 14.5 11.2 2.1 1 1 0 1 1 1 1 Zinc-binding domain RILP PF11461.6 001013285.1_16123001_1 - 0.02 15.0 0.0 18 5.5 0.0 3.3 3 0 0 3 3 3 0 Rab interacting lysosomal protein zf-H2C2_2 PF13465.4 001013285.1_16123001_2 - 8.3e-37 123.9 69.9 4.9e-08 32.9 3.7 8.6 9 1 0 9 9 8 5 Zinc-finger double domain zf-C2H2 PF00096.24 001013285.1_16123001_2 - 7.9e-34 114.1 71.7 3.7e-06 26.9 3.2 7.3 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001013285.1_16123001_2 - 3e-26 89.7 63.2 5.3e-05 23.6 0.3 7.6 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001013285.1_16123001_2 - 1.3e-12 47.6 34.3 0.011 15.9 1.9 7.3 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 001013285.1_16123001_2 - 1.7e-12 46.7 48.4 0.0043 16.6 0.7 7.2 7 0 0 7 7 7 5 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 001013285.1_16123001_2 - 3.2e-09 36.4 50.7 0.012 15.5 2.2 7.6 7 0 0 7 7 7 5 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001013285.1_16123001_2 - 3.4e-08 33.3 24.8 0.032 14.2 1.3 5.7 4 1 2 6 6 6 4 Zinc ribbon domain zf-C2HE PF16278.3 001013285.1_16123001_2 - 1.4e-07 31.7 52.0 0.004 17.4 0.3 7.2 2 2 5 7 7 7 4 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.5 001013285.1_16123001_2 - 2e-07 31.0 54.0 0.0068 16.6 3.0 7.4 7 0 0 7 7 7 3 Zinc-finger of C2H2 type XPA_N PF01286.16 001013285.1_16123001_2 - 7.2e-06 25.8 23.8 0.66 9.9 0.1 7.0 7 0 0 7 7 7 2 XPA protein N-terminal C1_1 PF00130.20 001013285.1_16123001_2 - 1e-05 25.2 26.4 0.032 14.0 4.2 5.8 3 2 2 6 6 6 3 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-AN1 PF01428.14 001013285.1_16123001_2 - 7.3e-05 22.7 24.7 6.5 6.9 0.2 7.2 7 0 0 7 7 7 0 AN1-like Zinc finger zinc_ribbon_15 PF17032.3 001013285.1_16123001_2 - 8.4e-05 23.1 26.2 0.14 12.8 2.5 4.4 2 2 2 5 5 5 3 zinc-ribbon family zf-LYAR PF08790.9 001013285.1_16123001_2 - 0.00042 20.0 38.1 0.077 12.8 3.1 7.4 7 0 0 7 7 7 3 LYAR-type C2HC zinc finger zf-H2C2_5 PF13909.4 001013285.1_16123001_2 - 0.0014 18.2 0.9 0.0014 18.2 0.9 8.7 7 4 0 7 7 6 3 C2H2-type zinc-finger domain zinc_ribbon_9 PF14369.4 001013285.1_16123001_2 - 0.0039 17.3 17.6 10 6.3 0.0 6.9 7 0 0 7 7 7 0 zinc-ribbon Zn_Tnp_IS1595 PF12760.5 001013285.1_16123001_2 - 0.004 17.0 30.8 0.26 11.2 2.2 5.3 4 1 1 5 5 5 3 Transposase zinc-ribbon domain zf-trcl PF13451.4 001013285.1_16123001_2 - 0.005 16.6 24.4 0.46 10.3 0.1 6.9 6 1 0 6 6 6 1 Probable zinc-ribbon domain Yippee-Mis18 PF03226.12 001013285.1_16123001_2 - 0.01 15.9 1.1 0.01 15.9 1.1 4.5 5 1 2 7 7 5 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-C2H2_2 PF12756.5 001013285.1_16123001_2 - 0.013 15.7 43.4 0.024 14.8 7.1 6.5 1 1 5 6 6 6 0 C2H2 type zinc-finger (2 copies) GAGA PF09237.9 001013285.1_16123001_2 - 0.014 15.0 8.1 10 5.9 0.2 4.2 3 1 1 4 4 4 0 GAGA factor zf-C2HC_2 PF13913.4 001013285.1_16123001_2 - 0.02 14.6 0.1 0.02 14.6 0.1 7.0 7 0 0 7 7 7 0 zinc-finger of a C2HC-type ROS_MUCR PF05443.9 001013285.1_16123001_2 - 0.029 14.3 10.6 0.062 13.2 0.2 3.8 2 1 1 3 3 3 0 ROS/MUCR transcriptional regulator protein Elf1 PF05129.11 001013285.1_16123001_2 - 0.033 14.1 0.8 0.033 14.1 0.8 4.4 2 2 2 4 4 4 0 Transcription elongation factor Elf1 like Trm112p PF03966.14 001013285.1_16123001_2 - 0.22 12.0 4.9 0.6 10.6 0.1 3.2 2 1 0 2 2 2 0 Trm112p-like protein FYDLN_acid PF09538.8 001013285.1_16123001_2 - 0.51 10.9 29.6 1.3 9.7 3.1 6.8 4 3 4 8 8 8 0 Protein of unknown function (FYDLN_acid) zinc-ribbons_6 PF07191.10 001013285.1_16123001_2 - 0.58 10.1 28.9 49 3.9 8.2 5.6 2 2 1 3 3 3 0 zinc-ribbons DUF2256 PF10013.7 001013285.1_16123001_2 - 0.62 10.1 18.7 12 6.0 0.1 6.7 6 1 1 7 7 7 0 Uncharacterized protein conserved in bacteria (DUF2256) FYVE PF01363.19 001013285.1_16123001_2 - 1.3 9.1 35.9 0.83 9.7 8.7 4.7 1 1 3 4 4 4 0 FYVE zinc finger TerY_C PF15616.4 001013285.1_16123001_2 - 1.4 8.9 13.3 0.29 11.1 0.2 3.5 1 1 3 4 4 4 0 TerY-C metal binding domain Baculo_IE-1 PF05290.9 001013285.1_16123001_2 - 3.8 7.3 9.0 20 5.0 1.9 3.8 2 2 1 3 3 3 0 Baculovirus immediate-early protein (IE-0) DNA_RNApol_7kD PF03604.11 001013285.1_16123001_2 - 4.8 6.8 22.2 15 5.2 0.1 6.4 7 0 0 7 7 7 0 DNA directed RNA polymerase, 7 kDa subunit ADK_lid PF05191.12 001013285.1_16123001_2 - 5 7.1 25.4 0.36 10.7 1.1 4.6 3 2 0 3 3 3 0 Adenylate kinase, active site lid Protocadherin PF08374.9 001005394.1_16123001_2 - 0.0045 16.9 0.0 0.0063 16.4 0.0 1.1 1 0 0 1 1 1 1 Protocadherin LRR19-TM PF15176.4 001005394.1_16123001_2 - 0.04 13.8 0.0 0.064 13.1 0.0 1.2 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain TT_ORF2 PF02957.13 001005394.1_16123001_3 - 0.18 12.6 0.9 0.28 12.0 0.9 1.2 1 0 0 1 1 1 0 TT viral ORF2 Reprolysin_2 PF13574.4 200420.1_16127001_3 - 7.3e-33 114.0 0.1 1.7e-32 112.8 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 200420.1_16127001_3 - 1e-32 113.8 0.1 3e-32 112.2 0.1 1.9 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 200420.1_16127001_3 - 3.2e-26 92.1 0.1 7.9e-26 90.9 0.1 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 200420.1_16127001_3 - 4.4e-17 62.3 0.1 1e-16 61.1 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.21 200420.1_16127001_3 - 1.8e-14 54.2 32.0 1.8e-14 54.2 32.0 3.5 2 1 0 2 2 2 1 Disintegrin Pep_M12B_propep PF01562.17 200420.1_16127001_3 - 3.7e-10 40.0 1.5 3.7e-10 40.0 1.5 2.5 3 0 0 3 3 3 1 Reprolysin family propeptide Reprolysin PF01421.17 200420.1_16127001_3 - 3.1e-06 27.1 0.5 3.1e-06 27.1 0.5 2.8 2 1 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Peptidase_M66 PF10462.7 200420.1_16127001_3 - 0.039 12.8 0.1 0.08 11.7 0.1 1.4 1 0 0 1 1 1 0 Peptidase M66 Orthopox_A5L PF06193.9 200420.1_16127001_3 - 0.08 12.2 0.1 0.08 12.2 0.1 1.8 2 0 0 2 2 2 0 Orthopoxvirus A5L protein-like CutA1 PF03091.13 001159928.1_16123001_1 - 0.0014 18.3 0.1 0.0027 17.4 0.1 1.3 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein PIH1 PF08190.10 001159928.1_16123001_3 - 1.8e-54 185.7 1.3 1.2e-40 140.2 0.6 2.1 1 1 1 2 2 2 2 pre-RNA processing PIH1/Nop17 MRI PF15325.4 001159928.1_16123001_3 - 0.16 13.1 0.0 0.27 12.3 0.0 1.4 1 0 0 1 1 1 0 Modulator of retrovirus infection IRF PF00605.15 207054.2_16125001_3 - 1.7e-40 137.4 0.5 2.7e-40 136.7 0.5 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor Sugar_tr PF00083.22 001025488.1_16124001_1 - 5.1e-32 111.2 20.9 9.1e-32 110.4 20.9 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001025488.1_16124001_1 - 1.4e-19 70.1 53.9 1.3e-16 60.3 28.7 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily pKID PF02173.15 001017818.1_16123001_2 - 1.6e-21 75.4 2.5 3e-21 74.5 2.5 1.5 1 0 0 1 1 1 1 pKID domain FlaC_arch PF05377.9 001245036.1_16123001_3 - 0.013 15.7 3.8 22 5.4 1.0 4.7 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) DUF1192 PF06698.9 001245036.1_16123001_3 - 0.072 13.0 2.7 0.23 11.4 1.4 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1192) DUF4446 PF14584.4 001245036.1_16123001_3 - 0.11 12.3 0.1 0.11 12.3 0.1 4.4 2 1 3 5 5 4 0 Protein of unknown function (DUF4446) DUF4303 PF14136.4 001245036.1_16123001_3 - 0.21 11.3 3.7 0.99 9.1 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4303) Spc7 PF08317.9 001245036.1_16123001_3 - 0.3 9.8 34.7 0.34 9.6 19.2 2.5 1 1 1 2 2 2 0 Spc7 kinetochore protein NPV_P10 PF05531.10 001245036.1_16123001_3 - 0.31 11.4 7.7 3.4 8.1 0.1 3.7 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF812 PF05667.9 001245036.1_16123001_3 - 0.61 8.8 35.9 1.1 7.9 35.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DUF148 PF02520.15 001245036.1_16123001_3 - 0.67 9.9 24.7 1.9 8.5 4.6 3.9 1 1 3 4 4 4 0 Domain of unknown function DUF148 AMP-binding_C_2 PF14535.4 001245036.1_16123001_3 - 0.72 10.1 6.9 0.6 10.3 0.9 3.0 2 1 1 3 3 3 0 AMP-binding enzyme C-terminal domain Erythro-docking PF09277.9 001245036.1_16123001_3 - 0.94 9.3 6.3 2.2 8.1 0.8 3.4 3 0 0 3 3 3 0 Erythronolide synthase, docking DUF3584 PF12128.6 001245036.1_16123001_3 - 1 6.7 43.3 1.7 5.9 15.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) PaaX_C PF08223.9 001245036.1_16123001_3 - 1.7 8.8 11.5 0.74 10.0 0.1 3.6 3 1 0 3 3 3 0 PaaX-like protein C-terminal domain DASH_Dam1 PF08653.8 001245036.1_16123001_3 - 1.9 8.2 4.0 4.9 6.9 0.2 3.2 3 0 0 3 3 3 0 DASH complex subunit Dam1 DUF5082 PF16888.3 001245036.1_16123001_3 - 2 8.7 22.7 1.6 9.0 2.5 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF5082) DUF948 PF06103.9 001245036.1_16123001_3 - 8.2 6.6 18.8 2.2 8.5 0.8 4.5 1 1 3 5 5 5 0 Bacterial protein of unknown function (DUF948) Prominin PF05478.9 001245036.1_16123001_3 - 8.7 4.0 17.8 2.5 5.8 11.8 2.1 1 1 1 2 2 2 0 Prominin WH2 PF02205.18 001328038.1_16126001_2 - 2.5e-07 30.2 1.0 3.6e-07 29.7 0.2 1.8 2 0 0 2 2 2 1 WH2 motif FERM_M PF00373.16 200904.2_16125001_3 - 4.6e-44 149.5 0.2 7.2e-44 148.8 0.2 1.3 1 0 0 1 1 1 1 FERM central domain PH PF00169.27 200904.2_16125001_3 - 3.8e-10 40.1 0.1 8.2e-10 39.0 0.1 1.5 1 0 0 1 1 1 1 PH domain FERM_N PF09379.8 200904.2_16125001_3 - 3.2e-05 23.6 0.0 7.1e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 FERM N-terminal domain PH_11 PF15413.4 200904.2_16125001_3 - 0.026 14.8 4.6 0.14 12.5 2.3 2.9 2 1 1 3 3 3 0 Pleckstrin homology domain DUF4806 PF16064.3 001100099.1_16123001_1 - 7.1e-12 45.3 0.1 7e-11 42.1 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4806) Retrotran_gag_2 PF14223.4 001100099.1_16123001_2 - 0.012 15.2 0.1 0.018 14.6 0.1 1.2 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Not3 PF04065.13 199840.1_16126001_2 - 2e-96 321.7 30.2 3.6e-96 320.9 30.2 1.4 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.16 199840.1_16126001_2 - 4.7e-20 71.8 1.8 4.7e-20 71.8 1.8 2.1 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family DUF4140 PF13600.4 199840.1_16126001_2 - 7.3 7.0 7.5 2.8 8.3 0.8 2.9 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) p450 PF00067.20 001006080.1_16124001_1 - 7.1e-120 400.7 0.1 8.5e-120 400.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Histone PF00125.22 212996.1_16122001_3 - 2.2e-53 180.0 0.8 3.1e-53 179.5 0.8 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.4 212996.1_16122001_3 - 0.00017 21.5 0.0 0.00035 20.5 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.4 212996.1_16122001_3 - 0.00087 19.5 0.0 0.0014 18.9 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein Ig_3 PF13927.4 001007428.1_16125001_2 - 4.7e-25 87.9 0.6 8.9e-13 48.5 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001007428.1_16125001_2 - 1.7e-22 79.4 0.3 2e-10 40.7 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 001007428.1_16125001_2 - 6e-21 74.3 0.6 1.4e-08 34.6 0.0 4.2 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 001007428.1_16125001_2 - 2.6e-15 56.1 0.0 4.9e-09 36.0 0.0 3.6 3 1 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.15 001007428.1_16125001_2 - 1.2e-14 54.3 3.2 3.8e-06 26.9 0.1 4.5 3 1 1 4 4 4 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 001007428.1_16125001_2 - 1.5e-10 40.9 0.4 4.2e-08 33.0 0.1 2.6 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 001007428.1_16125001_2 - 0.053 13.4 0.0 0.52 10.3 0.0 2.4 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.13 001007428.1_16125001_2 - 0.072 12.7 0.2 16 5.2 0.0 2.5 2 0 0 2 2 2 0 Adenovirus E3 region protein CR1 Internalin_N PF12354.6 001007428.1_16125001_2 - 0.21 11.5 0.5 18 5.4 0.0 2.5 2 0 0 2 2 2 0 Bacterial adhesion/invasion protein N terminal LRR_8 PF13855.4 001079979.1_16125001_2 - 6.9e-52 172.9 61.4 1.5e-12 46.9 1.9 7.1 3 2 4 7 7 7 7 Leucine rich repeat LRR_4 PF12799.5 001079979.1_16125001_2 - 8.7e-22 76.6 43.4 1.2e-06 28.6 1.0 6.9 6 0 0 6 6 6 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001079979.1_16125001_2 - 7.4e-20 71.1 0.4 1.1e-06 28.4 0.1 3.4 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001079979.1_16125001_2 - 3.6e-06 26.5 15.7 0.11 11.9 1.5 4.1 1 1 4 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.31 001079979.1_16125001_2 - 0.00028 20.8 43.0 1.6 9.4 0.6 11.1 10 2 0 10 10 10 4 Leucine Rich Repeat FNIP PF05725.10 001079979.1_16125001_2 - 0.1 12.6 1.2 0.58 10.2 1.2 2.4 1 0 0 1 1 1 0 FNIP Repeat Acetyltransf_CG PF14542.4 001013318.1_16123001_3 - 1e-21 76.7 0.1 2.1e-21 75.7 0.1 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase DUF4604 PF15377.4 001013318.1_16123001_3 - 0.51 10.6 19.7 0.86 9.9 19.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Guanylate_kin PF00625.19 001256189.1_16129001_2 - 2.9e-49 167.1 0.0 4.4e-49 166.5 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase L27 PF02828.14 001256189.1_16129001_2 - 1.5e-27 94.9 1.6 8.9e-16 57.3 0.3 2.7 2 0 0 2 2 2 2 L27 domain SH3_2 PF07653.15 001256189.1_16129001_2 - 1e-11 44.2 0.0 2.5e-11 43.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001256189.1_16129001_2 - 1.8e-10 40.1 0.1 3.3e-10 39.3 0.1 1.4 1 0 0 1 1 1 1 SH3 domain PDZ PF00595.22 001256189.1_16129001_2 - 4.6e-10 39.6 0.2 8.3e-10 38.8 0.2 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SH3_9 PF14604.4 001256189.1_16129001_2 - 3.6e-05 23.4 0.0 7.3e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PDZ_2 PF13180.4 001256189.1_16129001_2 - 0.00034 20.7 0.0 0.00078 19.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Pkinase PF00069.23 001037676.2_16129001_2 - 1.5e-64 217.8 0.0 3.4e-64 216.6 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.20 001037676.2_16129001_2 - 3.1e-60 204.0 0.0 4.7e-60 203.4 0.0 1.3 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.15 001037676.2_16129001_2 - 4.2e-48 163.8 0.0 6.9e-48 163.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase BING4CT PF08149.9 200623.1_16124001_3 - 2.5e-36 123.2 0.0 7.6e-33 112.0 0.0 3.8 3 0 0 3 3 3 2 BING4CT (NUC141) domain WD40 PF00400.30 200623.1_16124001_3 - 0.00046 20.8 0.4 0.023 15.4 0.0 3.7 5 0 0 5 5 5 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.12 200623.1_16124001_3 - 0.0029 16.6 0.0 0.0055 15.7 0.0 1.3 1 0 0 1 1 1 1 Coatomer WD associated region ANAPC4_WD40 PF12894.5 200623.1_16124001_3 - 0.024 14.8 0.0 19 5.5 0.1 3.9 2 1 4 6 6 6 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4604 PF15377.4 200623.1_16124001_3 - 3.7 7.8 26.6 6.1 7.1 8.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) SH3_2 PF07653.15 001128754.1_16121001_2 - 1.8e-09 37.0 0.0 2.7e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 001128754.1_16121001_2 - 0.0009 18.9 0.1 0.0024 17.6 0.1 1.7 1 1 0 1 1 1 1 Variant SH3 domain Clat_adaptor_s PF01217.18 001005964.1_16123001_3 - 1.9e-51 173.6 2.1 2.6e-51 173.2 2.1 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Homeobox PF00046.27 001328358.1_16123001_1 - 1.3e-21 76.0 7.0 1.3e-21 76.0 7.0 1.7 2 0 0 2 2 2 1 Homeobox domain QLQ PF08880.9 001328358.1_16123001_1 - 0.0027 17.3 0.4 0.0052 16.4 0.4 1.4 1 0 0 1 1 1 1 QLQ NOA36 PF06524.10 001328358.1_16123001_1 - 0.0097 15.2 1.8 0.013 14.8 1.8 1.1 1 0 0 1 1 1 1 NOA36 protein Astro_capsid_p PF12226.6 001328358.1_16123001_1 - 0.078 12.0 3.2 0.11 11.5 3.2 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RNA_pol_3_Rpc31 PF11705.6 001328358.1_16123001_1 - 0.1 12.7 7.7 0.15 12.1 7.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF4746 PF15928.3 001328358.1_16123001_1 - 0.22 10.8 7.5 0.3 10.3 7.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Ycf1 PF05758.10 001328358.1_16123001_1 - 0.34 8.6 2.7 0.46 8.2 2.7 1.1 1 0 0 1 1 1 0 Ycf1 DFRP_C PF16543.3 001328358.1_16123001_1 - 0.35 11.2 7.9 0.61 10.5 7.9 1.4 1 0 0 1 1 1 0 DRG Family Regulatory Proteins, Tma46 Nucleo_P87 PF07267.9 001328358.1_16123001_1 - 0.69 8.6 3.7 0.89 8.2 3.7 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 VID27 PF08553.8 001328358.1_16123001_1 - 1.6 7.0 7.3 2.1 6.6 7.3 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein CENP-B_dimeris PF09026.8 001328358.1_16123001_1 - 2 8.8 9.5 3.4 8.0 9.5 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Ribosomal_60s PF00428.17 001328358.1_16123001_1 - 4.6 7.7 12.1 9.8 6.7 12.1 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein Ribosomal_L11_N PF03946.12 001328358.1_16123001_2 - 0.26 10.9 1.1 0.48 10.1 1.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L11, N-terminal domain MRP-S31 PF15433.4 001128328.1_16123001_1 - 4.1e-111 371.5 3.2 4.1e-111 371.5 3.2 1.6 2 0 0 2 2 2 1 Mitochondrial 28S ribosomal protein S31 RGS PF00615.17 001002541.1_16125001_3 - 5.1e-34 116.9 0.8 1.6e-33 115.3 0.1 2.2 2 0 0 2 2 2 1 Regulator of G protein signaling domain DEP PF00610.19 001002541.1_16125001_3 - 3.1e-18 65.5 0.0 1.2e-17 63.6 0.0 2.0 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.20 001002541.1_16125001_3 - 3.7e-13 49.1 0.2 8.7e-13 48.0 0.2 1.7 1 0 0 1 1 1 1 GGL domain FlxA PF14282.4 001002541.1_16125001_3 - 0.11 12.4 0.3 0.29 11.0 0.3 1.6 1 0 0 1 1 1 0 FlxA-like protein Ank_4 PF13637.4 200150.1_16124001_2 - 2.6e-24 85.1 0.0 2.3e-09 37.4 0.0 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 200150.1_16124001_2 - 2.3e-20 71.9 0.1 5.2e-05 23.4 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.5 200150.1_16124001_2 - 1.2e-19 70.5 0.0 2.8e-12 46.9 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 200150.1_16124001_2 - 1.6e-19 69.5 0.1 1.3e-08 34.8 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 200150.1_16124001_2 - 5.8e-17 59.9 0.0 0.00018 21.6 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat TPR_1 PF00515.26 001080644.2_16126001_3 - 1.6e-13 49.7 0.0 5.1e-05 22.8 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.15 001080644.2_16126001_3 - 1.5e-12 46.5 0.0 4.3e-05 23.2 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.4 001080644.2_16126001_3 - 1.2e-09 38.1 0.3 0.00056 20.0 0.0 3.2 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 001080644.2_16126001_3 - 2.2e-08 34.3 0.0 1.4e-05 25.4 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.4 001080644.2_16126001_3 - 9.3e-08 32.5 0.0 3.6e-05 24.2 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.4 001080644.2_16126001_3 - 7.2e-06 25.9 0.2 0.26 11.6 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.4 001080644.2_16126001_3 - 1.4e-05 24.8 0.4 1.2 9.4 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.4 001080644.2_16126001_3 - 1.6e-05 25.1 0.0 1.2 9.7 0.0 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat ANAPC3 PF12895.5 001080644.2_16126001_3 - 9.6e-05 22.4 0.6 0.0088 16.1 0.2 2.8 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.4 001080644.2_16126001_3 - 0.00038 20.9 0.0 0.29 11.9 0.0 3.9 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.4 001080644.2_16126001_3 - 0.0017 17.9 0.1 0.0057 16.2 0.0 2.0 2 0 0 2 2 2 1 TPR repeat TPR_9 PF13371.4 001080644.2_16126001_3 - 0.0051 16.8 0.0 0.034 14.2 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat Paf67 PF10255.7 001080644.2_16126001_3 - 0.0093 14.9 0.9 0.15 10.9 0.0 2.2 1 1 1 2 2 2 1 RNA polymerase I-associated factor PAF67 Coatomer_E PF04733.12 001080644.2_16126001_3 - 0.0095 15.2 0.1 0.021 14.1 0.1 1.6 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_7 PF13176.4 001080644.2_16126001_3 - 0.06 13.3 0.0 21 5.3 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat RPN7 PF10602.7 001080644.2_16126001_3 - 0.092 12.2 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 26S proteasome subunit RPN7 zf-H2C2_2 PF13465.4 001037407.1_16126001_3 - 3.6e-105 340.0 152.8 3.1e-08 33.6 0.5 22.4 22 0 0 22 22 22 21 Zinc-finger double domain zf-C2H2 PF00096.24 001037407.1_16126001_3 - 2e-72 235.7 181.3 6.7e-06 26.1 3.8 20.9 21 0 0 21 21 20 19 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001037407.1_16126001_3 - 8.4e-63 203.4 166.9 6.6e-05 23.3 2.5 21.4 21 0 0 21 21 20 20 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001037407.1_16126001_3 - 1.6e-40 136.2 125.6 0.00074 19.3 2.2 20.7 20 0 0 20 20 20 17 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001037407.1_16126001_3 - 7.2e-20 70.7 114.7 0.018 15.2 0.5 19.9 19 1 1 20 20 20 13 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001037407.1_16126001_3 - 2.8e-07 30.6 126.9 0.012 15.9 1.9 19.6 20 0 0 20 20 20 9 Zinc-finger of C2H2 type ADK_lid PF05191.12 001037407.1_16126001_3 - 3.9e-06 26.6 74.3 0.77 9.7 1.9 12.0 10 2 2 12 12 11 8 Adenylate kinase, active site lid zf-H2C2_5 PF13909.4 001037407.1_16126001_3 - 5.1e-05 22.8 6.8 0.00079 19.0 0.5 17.4 18 2 0 18 18 18 6 C2H2-type zinc-finger domain zinc_ribbon_15 PF17032.3 001037407.1_16126001_3 - 0.00016 22.2 83.9 0.18 12.4 0.7 11.1 2 2 7 10 10 10 4 zinc-ribbon family C1_1 PF00130.20 001037407.1_16126001_3 - 0.0022 17.7 103.1 0.13 12.0 1.0 16.1 7 4 12 19 19 18 6 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_11 PF16622.3 001037407.1_16126001_3 - 0.0027 17.3 1.0 0.057 13.1 0.2 16.3 18 0 0 18 18 18 4 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 001037407.1_16126001_3 - 0.014 15.3 96.4 0.29 11.2 2.2 14.2 7 4 10 17 17 17 0 Zinc ribbon domain WAC_Acf1_DNA_bd PF10537.7 001037407.1_16126001_3 - 0.019 15.4 4.0 1.3 9.5 0.1 4.3 3 1 0 3 3 3 0 ATP-utilising chromatin assembly and remodelling N-terminal MBD PF01429.17 001037407.1_16126001_3 - 0.03 13.9 0.0 0.17 11.5 0.0 2.3 1 0 0 1 1 1 0 Methyl-CpG binding domain zf-C2HC_2 PF13913.4 001037407.1_16126001_3 - 0.58 10.0 93.5 0.45 10.3 0.2 17.6 19 0 0 19 19 18 0 zinc-finger of a C2HC-type DUF3268 PF11672.6 001037407.1_16126001_3 - 0.63 10.3 63.2 0.87 9.8 0.5 10.4 8 3 2 12 12 12 0 zinc-finger-containing domain GAGA PF09237.9 001037407.1_16126001_3 - 1.1 9.0 15.2 3.8 7.3 0.1 5.9 5 1 1 6 6 6 0 GAGA factor PID PF00640.21 198980.1_16123001_3 - 4.8e-16 58.9 0.3 1e-15 57.9 0.3 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID_2 PF14719.4 198980.1_16123001_3 - 1.1e-15 57.9 0.1 1.5e-15 57.4 0.1 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 198980.1_16123001_3 - 1.3e-08 34.9 0.1 2.3e-08 34.1 0.1 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain Gemin7 PF11095.6 001200037.1_16122001_2 - 1.2e-30 105.1 0.4 2.4e-30 104.1 0.3 1.6 2 0 0 2 2 2 1 Gem-associated protein 7 (Gemin7) SUZ-C PF12901.5 001200037.1_16122001_2 - 0.018 14.9 0.9 0.036 14.0 0.9 1.5 1 0 0 1 1 1 0 SUZ-C motif PID PF00640.21 001040386.1_16123001_1 - 6e-07 29.4 0.2 1.7e-06 27.9 0.1 1.8 1 1 1 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) Bac_globin PF01152.19 001040386.1_16123001_1 - 0.013 15.5 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial-like globin Glyco_hydro_79n PF03662.12 001045005.1_16124001_1 - 1.9e-28 99.2 0.1 4.4e-27 94.7 0.1 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 79, N-terminal domain Cu2_monooxygen PF01082.18 001045005.1_16124001_1 - 0.17 12.0 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 Copper type II ascorbate-dependent monooxygenase, N-terminal domain Myotub-related PF06602.12 001030126.1_16125001_3 - 3.8e-137 456.7 0.0 4.9e-137 456.3 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.18 001030126.1_16125001_3 - 0.016 14.9 0.0 0.033 13.9 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 001030126.1_16125001_3 - 0.058 13.2 0.0 0.093 12.5 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.25 001030126.1_16125001_3 - 0.075 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Arm PF00514.21 001114421.1_16127001_2 - 0.024 14.6 2.3 0.48 10.4 0.1 3.7 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Fez1 PF06818.13 001114421.1_16127001_2 - 1.4 9.2 38.9 0.039 14.3 18.7 3.2 1 1 1 2 2 2 0 Fez1 DUF641 PF04859.10 001114421.1_16127001_2 - 2.4 8.3 27.4 1.5 9.0 6.9 3.8 2 2 0 2 2 2 0 Plant protein of unknown function (DUF641) GAS PF13851.4 001114421.1_16127001_2 - 2.8 7.1 42.9 0.63 9.2 15.8 3.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Sec34 PF04136.13 001114421.1_16127001_2 - 6.2 6.6 25.0 1.2 8.9 1.0 4.2 2 1 1 3 3 3 0 Sec34-like family Reo_sigmaC PF04582.10 001114421.1_16127001_2 - 6.4 5.9 13.2 0.68 9.1 5.3 2.8 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Tropomyosin_1 PF12718.5 001114421.1_16127001_2 - 7.1 6.6 48.4 0.31 11.0 23.6 2.9 1 1 2 3 3 3 0 Tropomyosin like PRKG1_interact PF15898.3 001114421.1_16127001_2 - 7.8 7.3 42.4 0.41 11.5 12.3 3.6 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain adh_short PF00106.23 203511.1_16124001_1 - 2.1e-25 89.2 0.5 1.8e-24 86.1 0.5 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 203511.1_16124001_1 - 1.4e-18 67.2 0.2 6.4e-18 65.0 0.2 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 203511.1_16124001_1 - 2.4e-06 27.4 0.0 3.8e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 203511.1_16124001_1 - 0.0078 15.6 0.1 0.016 14.5 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.4 203511.1_16124001_1 - 0.038 13.8 0.6 0.099 12.4 0.3 1.9 2 1 0 2 2 2 0 NAD(P)H-binding GDP_Man_Dehyd PF16363.3 203511.1_16124001_1 - 0.039 13.2 0.0 0.059 12.6 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DUF1776 PF08643.8 203511.1_16124001_1 - 0.041 13.1 0.1 1.8 7.7 0.1 2.2 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) Porin_3 PF01459.20 001114438.1_16124001_3 - 4.6e-61 206.5 0.1 5.7e-61 206.2 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic porin PX PF00787.22 201123.2_16124001_3 - 6.3e-26 90.5 0.0 1.1e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 PX domain Pkinase PF00069.23 001326291.1_16129001_3 - 4.5e-32 111.3 0.0 6.4e-32 110.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001326291.1_16129001_3 - 1e-19 70.7 0.0 1.5e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase adh_short PF00106.23 200327.1_16124001_3 - 7.1e-49 165.8 0.4 9.3e-49 165.4 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 200327.1_16124001_3 - 2.2e-37 128.7 0.0 3e-37 128.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 200327.1_16124001_3 - 1.1e-05 25.3 0.0 1.7e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 200327.1_16124001_3 - 0.023 14.0 0.0 0.032 13.5 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Palm_thioest PF02089.13 200684.2_16124001_1 - 1.5e-15 57.0 0.0 2.4e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF676 PF05057.12 200684.2_16124001_1 - 2.1e-07 30.5 0.0 3e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.18 200684.2_16124001_1 - 0.00013 21.5 0.1 0.00075 19.1 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold PGAP1 PF07819.11 200684.2_16124001_1 - 0.00025 20.7 0.1 0.034 13.7 0.1 2.8 2 1 0 2 2 2 1 PGAP1-like protein Lipase_2 PF01674.16 200684.2_16124001_1 - 0.00035 20.1 0.0 0.0006 19.3 0.0 1.4 1 1 0 1 1 1 1 Lipase (class 2) Abhydrolase_6 PF12697.5 200684.2_16124001_1 - 0.18 12.3 0.0 0.25 11.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Glyco_transf_7N PF13733.4 001007401.1_16124001_3 - 5.3e-59 197.5 0.2 8.6e-59 196.9 0.2 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.12 001007401.1_16124001_3 - 8e-28 95.8 0.1 1.4e-27 95.0 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase C2 PF00168.28 001017652.1_16124001_1 - 8.7e-17 61.2 0.0 3.3e-11 43.3 0.0 2.2 2 0 0 2 2 2 2 C2 domain PI3K_C2 PF00792.22 001017652.1_16124001_1 - 0.015 15.3 0.0 0.032 14.2 0.0 1.6 1 0 0 1 1 1 0 Phosphoinositide 3-kinase C2 Cyclin_N PF00134.21 199951.2_16126001_1 - 2e-12 46.9 3.3 1.5e-11 44.0 0.8 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.3 199951.2_16126001_1 - 2.7e-06 27.6 0.1 5.9e-06 26.5 0.1 1.6 1 0 0 1 1 1 1 Cyclin C-terminal domain TFIIB PF00382.17 199951.2_16126001_1 - 0.11 12.4 0.1 0.61 10.0 0.0 2.1 2 0 0 2 2 2 0 Transcription factor TFIIB repeat Complex1_LYR PF05347.13 001098759.1_16122001_3 - 1.3e-05 25.0 1.2 2.1e-05 24.4 1.2 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 001098759.1_16122001_3 - 0.095 13.3 0.5 0.15 12.7 0.5 1.3 1 0 0 1 1 1 0 Complex1_LYR-like Tetraspannin PF00335.18 001130818.1_16126001_2 - 4.5e-42 144.1 11.3 4.5e-42 144.1 11.3 2.0 2 0 0 2 2 2 1 Tetraspanin family RRM_1 PF00076.20 198364.1_16124001_3 - 3.2e-26 90.8 0.1 1.4e-14 53.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 198364.1_16124001_3 - 4.4e-07 29.8 0.1 0.028 14.4 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.9 198364.1_16124001_3 - 0.028 14.3 0.0 1.6 8.7 0.0 2.4 2 0 0 2 2 2 0 RNA binding motif Nup35_RRM_2 PF14605.4 198364.1_16124001_3 - 0.068 13.0 0.1 1.2 9.0 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Ribosomal_L7Ae PF01248.24 200046.3_16122001_1 - 3.8e-29 100.1 1.4 4.8e-29 99.8 1.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family BTG PF07742.10 212974.1_16125001_1 - 5.6e-38 129.2 0.0 8.5e-38 128.6 0.0 1.3 1 0 0 1 1 1 1 BTG family PAM2 PF07145.13 212974.1_16125001_1 - 6.8e-05 22.1 4.5 0.016 14.7 1.4 2.7 2 0 0 2 2 2 2 Ataxin-2 C-terminal region DUF788 PF05620.9 212974.1_16125001_2 - 0.14 12.0 2.4 0.22 11.3 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF788) ETRAMP PF09716.8 212974.1_16125001_2 - 0.72 9.8 11.6 1.9 8.4 11.6 1.8 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) CCDC32 PF14989.4 001198753.1_16123001_1 - 1.4e-56 190.6 0.2 1.8e-56 190.2 0.2 1.1 1 0 0 1 1 1 1 Coiled-coil domain containing 32 MHC_I PF00129.16 001287098.1_16123001_1 - 2.6e-40 137.8 2.4 3.4e-40 137.4 2.4 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001287098.1_16123001_1 - 1.3e-09 38.2 2.0 1.9e-09 37.8 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 001287098.1_16123001_1 - 0.0023 17.3 0.6 0.0034 16.8 0.6 1.2 1 0 0 1 1 1 1 MHC-I family domain GCV_H PF01597.17 001013457.1_16123001_1 - 4.2e-43 146.0 0.0 5.4e-43 145.6 0.0 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Fis1_TPR_C PF14853.4 001001406.1_16124001_1 - 0.0073 16.2 0.5 3.6 7.6 0.1 2.6 2 0 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_18 PF13512.4 001001406.1_16124001_1 - 0.18 11.7 4.9 0.61 10.0 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Whi5 PF08528.9 001001406.1_16124001_1 - 0.97 9.0 4.2 9 5.9 1.4 2.5 2 0 0 2 2 2 0 Whi5 like Gln-synt_C PF00120.22 182866.3_16126001_3 - 6.2e-17 61.5 0.0 1.5e-11 43.8 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.17 182866.3_16126001_3 - 9.4e-14 50.8 0.0 1.9e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain FYVE PF01363.19 001002412.1_16124001_3 - 4.3e-08 33.1 10.5 4.3e-08 33.1 10.5 2.5 2 0 0 2 2 2 1 FYVE zinc finger DUF1993 PF09351.8 001002412.1_16124001_3 - 0.77 9.7 4.2 0.36 10.8 0.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) Glyco_transf_54 PF04666.11 001077724.1_16126001_2 - 5.4e-124 412.6 0.3 9.5e-124 411.8 0.3 1.3 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Pkinase_Tyr PF07714.15 001199755.1_16124001_1 - 9.6e-63 211.7 0.0 1.4e-62 211.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001199755.1_16124001_1 - 5.7e-60 202.8 0.0 8.4e-60 202.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RBD PF02196.13 001199755.1_16124001_1 - 2.1e-27 94.9 0.2 4.7e-27 93.8 0.2 1.6 1 0 0 1 1 1 1 Raf-like Ras-binding domain C1_1 PF00130.20 001199755.1_16124001_1 - 5.7e-12 45.2 13.5 6.2e-12 45.1 10.0 2.3 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.4 001199755.1_16124001_1 - 8.6e-07 28.4 0.0 1.3e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like zf-RING-like PF08746.9 001199755.1_16124001_1 - 0.00024 21.2 5.6 0.0008 19.5 5.6 1.9 1 0 0 1 1 1 1 RING-like domain C1_2 PF03107.14 001199755.1_16124001_1 - 0.052 13.7 4.2 0.11 12.7 4.2 1.5 1 0 0 1 1 1 0 C1 domain Kdo PF06293.12 001199755.1_16124001_1 - 0.12 11.5 0.2 0.22 10.7 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_2 PF13639.4 001199755.1_16124001_1 - 6.8 6.9 12.3 1.8 8.8 8.5 2.1 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.4 001199755.1_16124001_1 - 8.7 6.1 11.6 1.6 8.5 7.2 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Sec63 PF02889.14 001123257.1_16129001_1 - 1.8e-175 581.0 6.4 2.2e-92 308.7 1.2 2.4 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.27 001123257.1_16129001_1 - 6.8e-54 182.2 0.1 1.9e-25 89.5 0.1 2.8 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.13 001123257.1_16129001_1 - 3.9e-27 95.2 0.0 1.8e-12 47.5 0.0 2.9 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.29 001123257.1_16129001_1 - 5.9e-13 49.0 0.3 1.7e-06 28.2 0.0 4.3 3 2 0 3 3 3 2 Helicase conserved C-terminal domain AAA_22 PF13401.4 001123257.1_16129001_1 - 1e-08 35.4 0.0 0.0017 18.5 0.0 3.5 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.4 001123257.1_16129001_1 - 2.5e-07 30.5 0.0 0.016 14.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain PhoH PF02562.14 001123257.1_16129001_1 - 0.00046 19.6 0.0 0.11 11.8 0.0 2.7 2 0 0 2 2 2 1 PhoH-like protein T2SSE PF00437.18 001123257.1_16129001_1 - 0.00053 19.0 0.0 0.41 9.5 0.0 2.7 2 0 0 2 2 2 2 Type II/IV secretion system protein UvrD-helicase PF00580.19 001123257.1_16129001_1 - 0.0082 15.6 1.3 1.8 7.9 0.0 3.3 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain IstB_IS21 PF01695.15 001123257.1_16129001_1 - 0.058 13.0 0.1 2.4 7.8 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_11 PF13086.4 001123257.1_16129001_1 - 0.75 9.3 3.6 8.2 5.9 0.0 3.7 3 1 0 4 4 4 0 AAA domain Pkinase PF00069.23 001144053.1_16122001_1 - 8e-62 208.9 0.0 9.2e-62 208.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001144053.1_16122001_1 - 3e-36 124.9 0.0 3.8e-36 124.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001144053.1_16122001_1 - 3.3e-07 30.3 0.2 0.00072 19.4 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.12 001144053.1_16122001_1 - 3.6e-06 26.3 0.0 5.1e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 001144053.1_16122001_1 - 0.0058 16.1 0.0 0.018 14.5 0.0 1.8 1 1 0 1 1 1 1 RIO1 family FTA2 PF13095.4 001144053.1_16122001_1 - 0.053 13.0 0.0 0.12 11.9 0.0 1.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.4 001144053.1_16122001_1 - 0.083 12.1 0.1 0.17 11.1 0.0 1.5 2 0 0 2 2 2 0 Kinase-like Uricase PF01014.16 001144053.1_16122001_1 - 0.16 12.3 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 Uricase zf-LSD1 PF06943.10 001144053.1_16122001_3 - 0.036 13.8 3.0 0.11 12.3 3.0 1.9 1 0 0 1 1 1 0 LSD1 zinc finger COG6 PF06419.9 001320347.1_16126001_2 - 7.1e-207 688.3 6.8 8.3e-207 688.1 6.8 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Sec34 PF04136.13 001320347.1_16126001_2 - 0.0016 18.2 1.5 0.0069 16.1 1.5 2.1 1 0 0 1 1 1 1 Sec34-like family SOGA PF11365.6 001320347.1_16126001_2 - 0.015 16.2 2.0 0.058 14.4 2.0 2.0 1 0 0 1 1 1 0 Protein SOGA DUF1664 PF07889.10 001320347.1_16126001_2 - 0.24 11.3 3.2 1.2 9.1 1.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.7 001320347.1_16126001_2 - 1 9.6 5.0 0.48 10.6 1.3 2.4 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TSNAXIP1_N PF15739.3 001320347.1_16126001_2 - 2.4 8.5 8.7 0.9 9.8 2.3 3.2 3 0 0 3 3 3 0 Translin-associated factor X-interacting N-terminus DUF972 PF06156.11 001320347.1_16126001_2 - 4.6 7.8 9.8 0.12 12.9 1.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF972) DEAD PF00270.27 213451.2_16124001_2 - 3.4e-44 150.5 0.3 5.4e-44 149.9 0.3 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 213451.2_16124001_2 - 4.4e-32 110.6 0.7 2.3e-30 105.1 0.1 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 213451.2_16124001_2 - 7.6e-08 32.4 0.0 1.3e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 213451.2_16124001_2 - 0.00044 20.5 0.3 0.0013 19.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 213451.2_16124001_2 - 0.00066 19.3 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.12 213451.2_16124001_2 - 0.023 14.5 0.0 0.084 12.7 0.0 1.9 2 0 0 2 2 2 0 Flavivirus DEAD domain Helicase_RecD PF05127.12 213451.2_16124001_2 - 0.031 14.0 0.0 0.053 13.2 0.0 1.3 1 0 0 1 1 1 0 Helicase AAA_22 PF13401.4 213451.2_16124001_2 - 0.12 12.5 0.2 0.53 10.4 0.2 2.0 1 1 0 1 1 1 0 AAA domain SNF2_N PF00176.21 213451.2_16124001_2 - 0.12 10.9 0.0 0.2 10.2 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain UvrD-helicase PF00580.19 213451.2_16124001_2 - 0.16 11.3 0.1 0.22 10.9 0.1 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Sld5 PF05916.9 001024439.1_16122001_3 - 5.2e-25 87.9 1.2 7.3e-25 87.4 1.2 1.2 1 0 0 1 1 1 1 GINS complex protein 7tm_1 PF00001.19 001135134.1_16123001_1 - 8.5e-69 231.6 12.1 1.2e-68 231.2 12.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001135134.1_16123001_1 - 3.3e-12 46.2 12.8 5.3e-12 45.5 12.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001135134.1_16123001_1 - 2.8e-08 33.7 15.0 5.4e-08 32.8 9.8 2.2 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001135134.1_16123001_1 - 7.4e-06 25.3 12.8 7.4e-06 25.3 12.8 1.5 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.7 001135134.1_16123001_1 - 0.036 13.2 18.3 1.3 8.1 18.3 3.2 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw OAD_gamma PF04277.11 205668.1_16124001_1 - 1.3 9.5 4.1 2.7 8.5 4.1 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain IPP-2 PF04979.12 205668.1_16124001_2 - 5e-40 137.1 11.7 5e-40 137.1 11.7 2.1 2 0 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) CutC PF03932.12 001006046.1_16123001_3 - 1.8e-75 252.8 0.0 2.3e-75 252.4 0.0 1.1 1 0 0 1 1 1 1 CutC family TRAM_LAG1_CLN8 PF03798.14 213148.1_16123001_2 - 0.0024 17.5 2.7 0.0034 17.0 2.7 1.1 1 0 0 1 1 1 1 TLC domain AD PF09793.7 213148.1_16123001_3 - 8.8e-25 86.5 0.3 8.8e-25 86.5 0.3 2.3 2 0 0 2 2 2 1 Anticodon-binding domain Gemin6 PF06372.10 213148.1_16123001_3 - 0.022 14.2 0.0 0.041 13.3 0.0 1.4 1 0 0 1 1 1 0 Gemin6 protein Ion_trans PF00520.29 001110410.1_16125001_1 - 3.4e-37 127.9 7.4 4.7e-37 127.4 7.4 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001110410.1_16125001_1 - 6.3e-26 90.4 0.0 1.5e-25 89.2 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 001110410.1_16125001_1 - 1.7e-13 50.2 3.1 1.7e-13 50.2 3.1 1.9 2 0 0 2 2 2 1 Ion channel Glyco_hydro_35 PF01301.17 001017547.1_16125001_3 - 5.9e-120 400.5 0.0 7.5e-120 400.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.13 001017547.1_16125001_3 - 5.6e-14 52.1 0.0 7e-12 45.2 0.0 2.1 1 1 0 1 1 1 1 Beta-galactosidase BetaGal_dom4_5 PF13364.4 001017547.1_16125001_3 - 7.2e-07 29.6 0.7 1.1e-05 25.8 0.0 2.5 2 1 0 2 2 2 1 Beta-galactosidase jelly roll domain EF-hand_7 PF13499.4 001327942.1_16123001_3 - 4.8e-24 84.5 3.6 2e-15 56.8 0.6 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.30 001327942.1_16123001_3 - 4.1e-23 79.0 11.8 1.8e-06 27.0 0.1 4.9 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.4 001327942.1_16123001_3 - 1.3e-20 71.4 4.6 6.9e-06 25.5 0.1 4.8 4 1 1 5 5 5 3 EF-hand domain EF-hand_5 PF13202.4 001327942.1_16123001_3 - 8.3e-14 50.3 12.3 0.00019 20.7 0.2 5.0 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.4 001327942.1_16123001_3 - 1.2e-10 40.8 11.8 9.4e-06 25.2 1.6 4.5 3 2 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001327942.1_16123001_3 - 0.00014 22.0 2.4 0.2 11.8 0.4 3.4 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.11 001327942.1_16123001_3 - 0.0015 18.3 2.6 0.23 11.2 2.6 3.3 1 1 0 1 1 1 1 Caleosin related protein p25-alpha PF05517.10 001327942.1_16123001_3 - 0.0031 17.6 0.5 0.092 12.8 0.1 2.4 2 0 0 2 2 2 1 p25-alpha EF-hand_9 PF14658.4 001327942.1_16123001_3 - 0.01 16.0 0.1 3.7 7.8 0.0 3.1 3 0 0 3 3 3 1 EF-hand domain EF-hand_4 PF12763.5 001327942.1_16123001_3 - 0.043 13.6 7.2 11 5.9 0.1 4.0 2 1 2 4 4 4 0 Cytoskeletal-regulatory complex EF hand IL3 PF02059.13 001327942.1_16123001_3 - 0.072 13.1 0.1 0.24 11.4 0.0 1.8 2 0 0 2 2 2 0 Interleukin-3 Dus PF01207.15 001003490.2_16123001_1 - 7e-71 238.7 0.2 8.9e-71 238.4 0.2 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.19 001003490.2_16123001_1 - 1.4e-10 40.9 0.4 1.2e-05 24.7 0.0 1.5 1 1 1 2 2 2 2 Histidine biosynthesis protein TMP-TENI PF02581.15 001003490.2_16123001_1 - 0.0042 16.3 0.1 0.0068 15.6 0.1 1.3 1 0 0 1 1 1 1 Thiamine monophosphate synthase/TENI DUF561 PF04481.10 001003490.2_16123001_1 - 0.022 13.8 0.1 0.037 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF561) NMO PF03060.13 001003490.2_16123001_1 - 0.024 13.9 0.1 0.051 12.8 0.1 1.5 1 1 0 1 1 1 0 Nitronate monooxygenase G3P_antiterm PF04309.10 001003490.2_16123001_1 - 0.054 12.8 0.0 0.1 11.8 0.0 1.5 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator ThiG PF05690.12 001003490.2_16123001_1 - 0.096 11.9 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG EF-hand_5 PF13202.4 001128341.1_16125001_2 - 0.0024 17.2 0.0 0.0046 16.3 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.30 001128341.1_16125001_2 - 0.0032 16.8 0.0 0.0079 15.6 0.0 1.7 1 0 0 1 1 1 1 EF hand S_100 PF01023.17 001128341.1_16125001_2 - 0.0043 16.6 0.1 0.0083 15.7 0.1 1.5 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 001128341.1_16125001_2 - 0.093 13.1 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair HC2 PF07382.9 001128341.1_16125001_2 - 6.5 6.6 38.4 9.7 6.1 38.4 1.2 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 Asp-B-Hydro_N PF05279.9 001128341.1_16125001_2 - 6.5 6.6 50.6 10 6.0 50.6 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Mitofilin PF09731.7 001128341.1_16125001_2 - 9.7 4.7 49.2 14 4.2 49.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein CD20 PF04103.13 001017714.1_16123001_2 - 6.1e-15 55.5 23.2 3.3e-13 49.9 23.2 2.2 1 1 0 1 1 1 1 CD20-like family Myb_DNA-bind_4 PF13837.4 001123290.1_16123001_2 - 8.6e-07 29.1 0.1 1.8e-06 28.1 0.1 1.6 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.7 001123290.1_16123001_2 - 0.0047 17.1 0.1 0.013 15.7 0.1 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like APG6 PF04111.10 001123290.1_16123001_2 - 0.45 9.7 13.8 0.34 10.1 11.0 2.1 2 0 0 2 2 2 0 Autophagy protein Apg6 Spc7 PF08317.9 001123290.1_16123001_2 - 0.6 8.8 11.6 1.1 7.9 11.6 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Bcr-Abl_Oligo PF09036.8 001123290.1_16123001_2 - 6.9 6.6 9.3 2.2 8.2 1.7 2.5 1 1 1 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain DZF PF07528.12 213236.2_16124001_1 - 3.2e-95 318.3 0.0 4.3e-95 317.9 0.0 1.2 1 0 0 1 1 1 1 DZF domain SMC_N PF02463.17 199542.2_16129001_3 - 1e-52 178.7 48.4 1.2e-51 175.2 48.4 3.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.11 199542.2_16129001_3 - 4.8e-22 78.3 0.4 4.8e-22 78.3 0.4 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.4 199542.2_16129001_3 - 4.1e-09 36.5 9.3 0.00012 21.9 1.2 2.9 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 199542.2_16129001_3 - 0.00099 18.6 0.0 0.0024 17.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Spc7 PF08317.9 199542.2_16129001_3 - 0.88 8.3 142.2 0.12 11.1 33.6 7.2 3 2 3 6 6 6 0 Spc7 kinetochore protein FXMRP1_C_core PF12235.6 152963.1_16125001_3 - 1e-43 149.1 2.9 1e-43 149.1 2.9 2.8 2 1 1 3 3 3 1 Fragile X-related 1 protein core C terminal FXMR_C2 PF16098.3 152963.1_16125001_3 - 9.1e-40 134.9 9.2 2.3e-39 133.6 9.2 1.8 1 0 0 1 1 1 1 Fragile X-related mental retardation protein C-terminal region 2 KH_1 PF00013.27 152963.1_16125001_3 - 1.2e-16 60.2 2.6 8.7e-09 34.9 0.2 2.8 3 0 0 3 3 3 2 KH domain Agenet PF05641.10 152963.1_16125001_3 - 4.6e-14 52.5 2.7 6.9e-09 35.9 0.2 3.1 3 0 0 3 3 3 2 Agenet domain KH_2 PF07650.15 152963.1_16125001_3 - 0.006 16.2 1.8 0.23 11.2 0.0 3.2 3 0 0 3 3 3 1 KH domain KH_4 PF13083.4 152963.1_16125001_3 - 0.11 12.2 0.5 6.7 6.5 0.3 3.0 2 1 0 2 2 2 0 KH domain FXR_C3 PF16097.3 152963.1_16125001_3 - 0.13 12.9 3.0 0.21 12.2 0.3 2.4 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 3 ADK PF00406.20 212596.1_16123001_2 - 1.6e-59 200.2 0.0 2.1e-59 199.8 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.4 212596.1_16123001_2 - 4.5e-25 88.5 0.0 8.4e-25 87.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.12 212596.1_16123001_2 - 1.2e-14 53.8 0.0 5e-14 51.9 0.0 2.1 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.4 212596.1_16123001_2 - 4.1e-05 23.6 0.0 0.00024 21.2 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.4 212596.1_16123001_2 - 0.021 15.2 0.0 0.039 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.16 212596.1_16123001_2 - 0.025 14.2 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_25 PF13481.4 212596.1_16123001_2 - 0.11 11.9 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain CD20 PF04103.13 001083012.1_16123001_1 - 2e-16 60.3 24.2 1.7e-14 54.0 24.2 2.3 1 1 0 1 1 1 1 CD20-like family OAD_gamma PF04277.11 001083012.1_16123001_1 - 0.0025 18.2 4.0 0.0025 18.2 4.0 2.6 2 0 0 2 2 2 1 Oxaloacetate decarboxylase, gamma chain SIT PF15330.4 001083012.1_16123001_1 - 0.98 9.7 6.2 2.3 8.5 0.8 2.4 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT DUF788 PF05620.9 001083012.1_16123001_3 - 0.042 13.6 2.1 0.061 13.1 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF788) OAD_gamma PF04277.11 001083012.1_16123001_3 - 0.11 13.0 4.7 0.16 12.4 4.7 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain SAP PF02037.25 001024407.2_16122001_1 - 7.2e-13 47.8 2.7 2.7e-12 46.0 0.8 2.8 3 0 0 3 3 3 1 SAP domain LETM1 PF07766.11 001024407.2_16122001_1 - 0.07 12.3 0.2 0.15 11.2 0.2 1.5 1 0 0 1 1 1 0 LETM1-like protein Telomere_Sde2_2 PF13297.4 001024407.2_16122001_1 - 1.6 8.3 5.7 0.25 10.9 0.5 2.4 3 0 0 3 3 3 0 Telomere stability C-terminal Paralemmin PF03285.13 001204256.1_16123001_3 - 2.9e-100 335.8 13.1 2.9e-100 335.8 13.1 1.4 2 0 0 2 2 2 1 Paralemmin DUF4472 PF14739.4 001204256.1_16123001_3 - 0.084 13.5 17.3 1.5 9.5 1.8 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) Cob_adeno_trans PF01923.16 001204256.1_16123001_3 - 0.29 11.1 6.3 0.56 10.2 6.3 1.4 1 0 0 1 1 1 0 Cobalamin adenosyltransferase V_ATPase_I PF01496.17 001204256.1_16123001_3 - 0.38 8.5 6.3 0.59 7.8 6.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Jnk-SapK_ap_N PF09744.7 001204256.1_16123001_3 - 0.98 9.5 23.7 2.5 8.2 23.7 1.7 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Connexin PF00029.17 131811.2_16124001_3 - 7.4e-81 271.1 5.8 7.4e-81 271.1 5.8 2.2 2 0 0 2 2 2 2 Connexin TMEM52 PF14979.4 131811.2_16124001_3 - 0.83 9.4 7.3 1.7 8.4 6.4 1.9 2 0 0 2 2 2 0 Transmembrane 52 BTB_2 PF02214.20 199799.1_16124001_3 - 6.2e-18 64.8 0.0 1.1e-17 64.1 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.29 199799.1_16124001_3 - 4.4e-06 26.8 0.0 8.7e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Cofilin_ADF PF00241.18 213639.2_16123001_3 - 1.8e-24 86.2 1.4 2.6e-24 85.7 1.4 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF2175 PF09943.7 213639.2_16123001_3 - 0.025 14.7 0.4 0.056 13.6 0.4 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) LicD PF04991.11 001089490.1_16125001_1 - 1.6e-14 54.5 1.6 8.1e-12 45.6 0.3 2.2 2 0 0 2 2 2 2 LicD family Spectrin PF00435.19 131522.2_16127001_1 - 8.6e-65 215.7 28.6 3.7e-21 75.5 6.9 4.3 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.29 131522.2_16127001_1 - 7.5e-54 180.4 1.0 8.8e-27 93.3 0.0 3.0 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.8 131522.2_16127001_1 - 2.9e-26 91.2 0.0 8.5e-26 89.7 0.0 1.9 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_1 PF00036.30 131522.2_16127001_1 - 2.5e-09 35.9 1.1 0.0026 17.1 0.1 3.1 3 0 0 3 3 3 2 EF hand CAMSAP_CH PF11971.6 131522.2_16127001_1 - 1e-07 31.6 0.0 2.1e-06 27.3 0.0 2.7 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_6 PF13405.4 131522.2_16127001_1 - 2.7e-06 26.7 0.2 0.0041 16.8 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 131522.2_16127001_1 - 2.7e-06 27.6 0.1 1.7e-05 25.1 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.4 131522.2_16127001_1 - 3.4e-05 23.4 2.5 0.0011 18.5 0.2 3.8 3 1 1 4 4 4 1 EF-hand domain pair XisI PF08869.9 131522.2_16127001_1 - 0.29 11.4 3.6 0.22 11.7 0.6 2.3 2 0 0 2 2 2 0 XisI protein BLOC1_2 PF10046.7 131522.2_16127001_1 - 8.8 6.6 8.3 12 6.2 0.4 3.8 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PH_13 PF16652.3 001003547.2_16129001_1 - 6.5e-67 224.1 1.1 6.5e-67 224.1 1.1 4.4 5 3 1 6 6 3 1 Pleckstrin homology domain SH3_9 PF14604.4 001003547.2_16129001_1 - 1.2e-51 172.2 5.7 2.3e-15 56.0 0.0 4.5 4 0 0 4 4 4 4 Variant SH3 domain SH3_1 PF00018.26 001003547.2_16129001_1 - 3.6e-47 157.6 8.2 1.1e-15 56.8 0.1 4.5 4 0 0 4 4 4 4 SH3 domain SH3_2 PF07653.15 001003547.2_16129001_1 - 7.2e-44 147.2 0.1 1.8e-12 46.6 0.0 4.5 4 0 0 4 4 4 4 Variant SH3 domain RhoGEF PF00621.18 001003547.2_16129001_1 - 9.2e-42 143.2 2.2 9.2e-42 143.2 2.2 2.6 2 1 0 2 2 1 1 RhoGEF domain EF-hand_4 PF12763.5 001003547.2_16129001_1 - 9.2e-28 96.1 0.0 7.1e-13 48.3 0.0 2.7 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand C2 PF00168.28 001003547.2_16129001_1 - 3.2e-19 69.0 0.0 8.9e-19 67.6 0.0 1.8 1 0 0 1 1 1 1 C2 domain EF-hand_1 PF00036.30 001003547.2_16129001_1 - 6.1e-09 34.7 0.1 0.002 17.4 0.0 3.0 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 001003547.2_16129001_1 - 1.5e-06 27.6 0.1 0.12 12.3 0.1 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 001003547.2_16129001_1 - 3.6e-06 27.2 0.1 0.0067 16.7 0.0 3.6 3 0 0 3 3 3 1 EF-hand domain pair PH PF00169.27 001003547.2_16129001_1 - 0.001 19.4 0.2 0.0058 17.0 0.1 2.4 2 0 0 2 2 2 1 PH domain EF-hand_5 PF13202.4 001003547.2_16129001_1 - 0.005 16.2 0.5 2.6 7.6 0.0 2.6 2 0 0 2 2 2 2 EF hand SIX1_SD PF16878.3 131783.2_16124001_2 - 3.5e-49 165.8 0.1 7.5e-49 164.7 0.1 1.6 1 0 0 1 1 1 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeobox PF00046.27 131783.2_16124001_2 - 1.2e-13 50.6 0.5 1.2e-13 50.6 0.5 2.1 3 0 0 3 3 3 1 Homeobox domain Homeobox_KN PF05920.9 131783.2_16124001_2 - 1.1e-12 47.4 0.7 2.5e-12 46.3 0.7 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.6 131783.2_16124001_2 - 0.015 14.7 0.1 0.031 13.6 0.1 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez HTH_3 PF01381.20 131783.2_16124001_2 - 0.024 14.6 0.0 0.063 13.2 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix YdaS_antitoxin PF15943.3 131783.2_16124001_2 - 0.18 11.6 0.0 0.35 10.6 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Homeobox_KN PF05920.9 001045227.1_16124001_2 - 8.8e-16 57.4 0.4 1.8e-15 56.4 0.4 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 001045227.1_16124001_2 - 4.1e-07 29.6 0.4 7.2e-07 28.8 0.4 1.4 1 0 0 1 1 1 1 Homeobox domain PGA2 PF07543.10 001045227.1_16124001_2 - 0.046 13.6 0.8 0.15 11.9 0.8 1.8 1 0 0 1 1 1 0 Protein trafficking PGA2 MRP-S32 PF10210.7 001045227.1_16124001_2 - 0.084 13.3 1.3 0.62 10.5 0.2 2.6 3 0 0 3 3 3 0 Mitochondrial 28S ribosomal protein S32 7tm_1 PF00001.19 001007358.2_16124001_2 - 1.7e-80 270.0 5.3 2.1e-80 269.7 5.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001007358.2_16124001_2 - 1.6e-13 50.5 5.0 2.5e-13 49.9 5.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001007358.2_16124001_2 - 2.2e-05 24.2 2.8 2.2e-05 24.2 2.8 2.5 3 0 0 3 3 3 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001007358.2_16124001_2 - 3.9e-05 23.0 5.2 3.9e-05 23.0 5.2 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Trypsin PF00089.24 001320402.1_16122001_1 - 6e-65 219.0 1.1 7e-65 218.8 1.1 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001320402.1_16122001_1 - 1.1e-07 32.7 0.0 1.6e-07 32.1 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001320402.1_16122001_1 - 0.0077 16.5 0.2 0.018 15.3 0.2 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Sugar_tr PF00083.22 001082995.1_16125001_1 - 9.4e-37 126.8 20.9 1.6e-32 112.9 3.4 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.14 001082995.1_16125001_1 - 1.3e-31 109.6 35.6 2.5e-21 75.9 12.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Pentapeptide_4 PF13599.4 001082995.1_16125001_1 - 1.1e-08 34.9 6.9 2.4e-08 33.8 6.9 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.4 001082995.1_16125001_1 - 0.00085 19.3 4.2 0.026 14.5 1.5 2.5 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) Pentapeptide PF00805.20 001082995.1_16125001_1 - 0.0029 17.1 1.7 0.15 11.6 0.3 2.7 2 1 0 2 2 2 1 Pentapeptide repeats (8 copies) MFS_1_like PF12832.5 001082995.1_16125001_1 - 0.036 12.8 12.3 0.28 9.9 5.1 2.6 2 1 0 2 2 2 0 MFS_1 like family MFS_2 PF13347.4 001082995.1_16125001_1 - 2.7 6.3 24.4 0.0039 15.6 9.6 2.5 2 1 0 2 2 2 0 MFS/sugar transport protein TPR_2 PF07719.15 001044905.2_16123001_2 - 0.007 16.3 8.1 0.53 10.4 1.8 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.4 001044905.2_16123001_2 - 0.0086 16.5 2.2 0.042 14.4 0.8 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.4 001044905.2_16123001_2 - 0.019 15.6 0.1 0.12 13.1 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.4 001044905.2_16123001_2 - 0.048 14.2 0.2 0.7 10.5 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 001044905.2_16123001_2 - 0.23 11.2 6.8 0.91 9.3 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.4 001044905.2_16123001_2 - 0.36 11.0 3.9 0.22 11.7 0.4 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 001044905.2_16123001_2 - 0.79 9.7 5.3 0.29 11.1 0.2 2.8 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat UPF0239 PF06783.9 001303006.1_16124001_1 - 9.4e-35 118.6 0.0 9.4e-35 118.6 0.0 1.8 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0239) CH PF00307.29 001103114.1_16123001_3 - 5.6e-19 68.2 0.0 1.1e-18 67.2 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain Calponin PF00402.16 001103114.1_16123001_3 - 6.9e-12 44.7 6.4 1.8e-11 43.3 6.4 1.8 1 0 0 1 1 1 1 Calponin family repeat Globin PF00042.20 001033093.1_16122001_1 - 2.8e-27 95.3 0.0 3.7e-27 94.9 0.0 1.2 1 0 0 1 1 1 1 Globin Glycos_transf_2 PF00535.24 001076562.2_16125001_3 - 1.2e-34 119.5 0.0 1.7e-34 118.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 001076562.2_16125001_3 - 2.8e-20 72.7 0.5 4.4e-20 72.1 0.5 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.4 001076562.2_16125001_3 - 7.7e-11 42.2 0.0 2.5e-10 40.5 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.7 001076562.2_16125001_3 - 3.1e-05 23.5 0.0 7.3e-05 22.2 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.12 001076562.2_16125001_3 - 0.00048 19.6 0.0 0.001 18.5 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase RicinB_lectin_2 PF14200.4 001076562.2_16125001_3 - 0.0042 17.7 0.4 5.7 7.6 0.8 2.4 2 0 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like fn3 PF00041.19 001346203.1_16129001_2 - 1e-83 275.6 6.8 5.1e-17 61.9 0.0 6.1 5 0 0 5 5 5 5 Fibronectin type III domain I-set PF07679.14 001346203.1_16129001_2 - 1e-66 220.9 6.9 5.5e-21 74.3 0.1 8.5 8 0 0 8 8 8 7 Immunoglobulin I-set domain Ig_3 PF13927.4 001346203.1_16129001_2 - 2.2e-41 140.2 4.4 1e-11 45.1 0.0 8.1 7 0 0 7 7 7 5 Immunoglobulin domain Ig_2 PF13895.4 001346203.1_16129001_2 - 8.3e-28 96.4 11.4 6.8e-10 39.0 0.2 6.7 8 0 0 8 8 7 3 Immunoglobulin domain ig PF00047.23 001346203.1_16129001_2 - 2.7e-24 85.0 15.0 9.3e-08 32.0 0.1 7.1 7 0 0 7 7 7 4 Immunoglobulin domain V-set PF07686.15 001346203.1_16129001_2 - 5.6e-17 61.7 16.8 0.0025 17.8 1.1 9.5 7 3 0 7 7 7 4 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.3 001346203.1_16129001_2 - 2.1e-10 40.9 10.5 0.014 15.8 0.1 6.9 7 0 0 7 7 6 3 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.15 001346203.1_16129001_2 - 4.4e-09 36.0 0.2 0.5 10.1 0.0 4.8 4 0 0 4 4 4 3 Tissue factor Receptor_2B4 PF11465.6 001346203.1_16129001_2 - 1.2e-08 35.0 0.3 0.021 14.9 0.0 5.2 5 1 1 6 6 5 2 Natural killer cell receptor 2B4 PhoD_N PF16655.3 001346203.1_16129001_2 - 0.0037 17.6 0.2 48 4.4 0.0 4.8 4 0 0 4 4 4 0 PhoD-like phosphatase, N-terminal domain C2-set_2 PF08205.10 001346203.1_16129001_2 - 0.0046 16.9 0.4 1 9.3 0.0 3.2 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 001346203.1_16129001_2 - 0.019 15.3 9.0 1 9.8 0.0 4.9 5 0 0 5 5 5 0 Immunoglobulin C1-set domain Interfer-bind PF09294.8 001346203.1_16129001_2 - 0.048 13.8 0.0 18 5.6 0.0 3.3 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III DUF4757 PF15949.3 001145577.1_16127001_2 - 5.1e-58 196.2 11.8 5.1e-58 196.2 11.8 3.3 4 0 0 4 4 4 1 Domain of unknown function (DUF4757) CH PF00307.29 001145577.1_16127001_2 - 7e-11 42.2 0.0 1.4e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain LIM PF00412.20 001145577.1_16127001_2 - 3e-08 33.6 1.5 7.8e-08 32.3 1.5 1.8 1 0 0 1 1 1 1 LIM domain SapB_2 PF03489.15 131883.2_16125001_1 - 1.5e-44 149.7 24.1 5.5e-12 45.4 0.8 5.0 4 0 0 4 4 4 4 Saposin-like type B, region 2 SapB_1 PF05184.13 131883.2_16125001_1 - 2.1e-42 142.5 26.2 9.1e-14 51.0 0.1 4.9 4 0 0 4 4 4 4 Saposin-like type B, region 1 SapA PF02199.13 131883.2_16125001_1 - 8.6e-32 108.9 28.0 4.6e-16 58.5 7.5 3.6 3 0 0 3 3 3 2 Saposin A-type domain HD_3 PF13023.4 131883.2_16125001_1 - 0.084 12.7 0.0 6.3 6.6 0.0 2.4 2 0 0 2 2 2 0 HD domain DUF3456 PF11938.6 131883.2_16125001_1 - 6.4 7.1 20.6 11 6.3 0.1 5.4 4 3 3 7 7 7 0 TLR4 regulator and MIR-interacting MSAP DSPc PF00782.18 001002514.1_16123001_2 - 1.5e-29 102.3 0.1 2.3e-29 101.7 0.1 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 001002514.1_16123001_2 - 0.00093 18.7 0.9 0.0016 17.9 0.4 1.5 1 1 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.4 001002514.1_16123001_2 - 0.0028 17.7 0.1 0.005 16.8 0.1 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate V-set PF07686.15 001346412.1_16129001_3 - 7.5e-17 61.3 0.0 1.4e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 001346412.1_16129001_3 - 4.5e-05 23.4 0.0 8.4e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001346412.1_16129001_3 - 0.00014 22.2 0.1 0.00032 21.1 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001346412.1_16129001_3 - 0.014 15.3 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain DUF1191 PF06697.10 001346412.1_16129001_3 - 0.13 11.4 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) TMEM232 PF15877.3 001100053.1_16124001_1 - 1.7e-83 281.1 28.6 5.7e-79 266.1 12.8 3.8 2 1 1 3 3 3 2 Transmembrane protein family 232 HEAT_2 PF13646.4 001100053.1_16124001_1 - 0.0091 16.2 0.0 0.034 14.4 0.0 2.0 1 0 0 1 1 1 1 HEAT repeats RFXA_RFXANK_bdg PF15289.4 001326367.1_16123001_3 - 1e-54 184.0 6.4 1.4e-54 183.5 6.4 1.2 1 0 0 1 1 1 1 Regulatory factor X-associated C-terminal binding domain ELO PF01151.16 001204524.1_16123001_2 - 4.3e-66 222.9 24.9 5.7e-66 222.4 24.9 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family Pentaxin PF00354.15 001040297.1_16123001_3 - 3.4e-49 167.0 0.0 4.7e-49 166.6 0.0 1.1 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.4 001040297.1_16123001_3 - 2.3e-10 40.7 0.0 3.2e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Glyco_transf_29 PF00777.16 001204155.1_16123001_1 - 5.5e-76 255.3 0.0 7.4e-76 254.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) RPEL PF02755.13 001020537.1_16125001_1 - 1.4e-17 62.6 22.0 1.7e-06 27.4 1.0 4.0 4 0 0 4 4 4 3 RPEL repeat Sod_Ni PF09055.9 001020537.1_16125001_1 - 0.21 12.0 0.7 0.42 11.0 0.7 1.4 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase CNTF PF01110.15 001145632.1_16123001_3 - 0.055 12.7 0.2 0.091 12.0 0.2 1.3 1 1 0 1 1 1 0 Ciliary neurotrophic factor Spermine_synth PF01564.15 131756.1_16124001_1 - 8.2e-62 208.2 0.0 1.1e-61 207.8 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_12 PF08242.10 131756.1_16124001_1 - 0.015 15.9 0.0 0.039 14.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.4 131756.1_16124001_1 - 0.021 15.4 0.0 0.048 14.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DUF43 PF01861.14 131756.1_16124001_1 - 0.15 11.1 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF43 Citrate_bind PF16114.3 131756.1_16124001_1 - 0.16 11.3 0.0 0.35 10.2 0.0 1.4 1 0 0 1 1 1 0 ATP citrate lyase citrate-binding Carb_anhydrase PF00194.19 001114407.1_16126001_1 - 1.6e-91 306.3 0.0 2e-91 305.9 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase TAS2R PF05296.11 001100629.1_16122001_1 - 3.3e-14 52.6 26.3 4.1e-14 52.2 26.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001100629.1_16122001_1 - 0.00026 20.2 6.2 0.00026 20.2 6.2 2.2 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) RILP PF11461.6 001083850.1_16125001_1 - 1e-20 73.5 5.2 1.8e-20 72.8 5.2 1.4 1 0 0 1 1 1 1 Rab interacting lysosomal protein Jnk-SapK_ap_N PF09744.7 001083850.1_16125001_1 - 0.0016 18.6 4.1 0.0031 17.6 4.1 1.5 1 1 0 1 1 1 1 JNK_SAPK-associated protein-1 Mod_r PF07200.11 001083850.1_16125001_1 - 0.028 14.4 6.9 0.039 13.9 5.9 1.7 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF4140 PF13600.4 001083850.1_16125001_1 - 0.089 13.1 0.1 2.9 8.3 0.0 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) HIP1_clath_bdg PF16515.3 001083850.1_16125001_1 - 0.25 11.8 4.0 7.1 7.2 0.1 2.2 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF3523 PF12037.6 205703.1_16125001_3 - 4.8e-109 363.7 21.8 7.5e-109 363.0 21.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) AAA PF00004.27 205703.1_16125001_3 - 2.9e-20 72.9 0.0 6.4e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 205703.1_16125001_3 - 6.5e-05 23.2 4.3 0.0017 18.6 0.0 3.4 2 1 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.19 205703.1_16125001_3 - 0.0013 18.1 0.0 0.0059 15.9 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.4 205703.1_16125001_3 - 0.0026 17.4 0.0 0.0059 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.10 205703.1_16125001_3 - 0.0039 16.4 0.0 0.0091 15.1 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.4 205703.1_16125001_3 - 0.0047 17.1 5.8 0.49 10.5 0.1 3.1 3 1 0 3 3 3 2 AAA domain ATPase PF06745.11 205703.1_16125001_3 - 0.0048 16.1 0.3 0.013 14.8 0.0 1.8 2 0 0 2 2 2 1 KaiC AAA_5 PF07728.12 205703.1_16125001_3 - 0.015 15.2 1.6 0.061 13.2 0.0 2.7 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.4 205703.1_16125001_3 - 0.018 15.0 5.2 0.02 14.9 0.0 2.8 2 1 0 2 2 2 0 AAA domain Zot PF05707.10 205703.1_16125001_3 - 0.041 13.4 0.1 1.3 8.5 0.0 2.7 1 1 1 2 2 2 0 Zonular occludens toxin (Zot) RNA_helicase PF00910.20 205703.1_16125001_3 - 0.055 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Sigma54_activ_2 PF14532.4 205703.1_16125001_3 - 0.067 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Rhodanese PF00581.18 001326449.1_16122001_1 - 4.5e-16 59.2 0.0 6.4e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain TPR_1 PF00515.26 201156.1_16126001_1 - 1.5e-21 75.1 0.1 6.6e-05 22.4 0.1 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.15 201156.1_16126001_1 - 9e-20 69.0 2.6 0.0003 20.5 0.3 6.0 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_11 PF13414.4 201156.1_16126001_1 - 6e-17 60.9 0.1 6.6e-05 22.4 0.0 5.9 3 1 2 5 5 5 2 TPR repeat TPR_14 PF13428.4 201156.1_16126001_1 - 1.6e-16 59.4 10.6 0.0025 18.3 0.0 7.2 4 2 3 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.4 201156.1_16126001_1 - 1.9e-15 55.6 0.0 0.0011 18.8 0.0 5.3 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.4 201156.1_16126001_1 - 1.9e-13 50.7 10.4 6.9e-07 29.7 1.2 4.9 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_17 PF13431.4 201156.1_16126001_1 - 2.9e-12 45.9 2.4 0.1 12.9 0.0 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.4 201156.1_16126001_1 - 3e-11 43.5 2.6 0.00036 20.8 0.5 4.1 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 201156.1_16126001_1 - 9.4e-09 35.3 5.2 0.00065 19.8 0.2 4.0 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.4 201156.1_16126001_1 - 2.5e-08 33.2 2.2 0.38 10.8 0.0 5.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_10 PF13374.4 201156.1_16126001_1 - 1e-06 28.3 5.0 0.0097 15.6 0.2 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.4 201156.1_16126001_1 - 1.2e-06 28.6 4.6 6.8 7.4 0.1 6.6 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_9 PF13371.4 201156.1_16126001_1 - 5.2e-06 26.4 5.9 0.036 14.1 0.3 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.4 201156.1_16126001_1 - 6.1e-06 26.4 1.3 0.24 11.6 0.0 3.9 2 1 1 3 3 3 2 Tetratricopeptide repeat MAS20 PF02064.13 201156.1_16126001_1 - 6.4e-05 22.9 1.2 0.0081 16.1 0.0 3.2 3 1 1 4 4 4 1 MAS20 protein import receptor ANAPC3 PF12895.5 201156.1_16126001_1 - 0.00073 19.6 1.0 0.77 9.9 0.1 2.8 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TMEM189_B_dmain PF10520.7 001080164.1_16125001_3 - 1.7e-78 262.7 3.9 2.8e-78 262.0 3.9 1.4 1 0 0 1 1 1 1 B domain of TMEM189, localisation domain FA_hydroxylase PF04116.11 001080164.1_16125001_3 - 2.8 8.2 13.6 0.42 10.8 7.5 2.1 1 1 1 2 2 2 0 Fatty acid hydroxylase superfamily A2M_comp PF07678.12 001201405.2_16129001_3 - 4e-67 226.1 0.0 7e-67 225.4 0.0 1.4 1 0 0 1 1 1 1 A-macroglobulin complement component A2M_N_2 PF07703.12 001201405.2_16129001_3 - 2.4e-31 108.8 5.9 5.6e-28 97.9 0.3 4.1 3 0 0 3 3 3 2 Alpha-2-macroglobulin family N-terminal region A2M PF00207.20 001201405.2_16129001_3 - 3e-28 97.3 0.0 1e-27 95.7 0.0 2.0 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_recep PF07677.12 001201405.2_16129001_3 - 9.3e-23 80.7 0.2 3.4e-22 78.9 0.2 2.1 1 0 0 1 1 1 1 A-macroglobulin receptor Thiol-ester_cl PF10569.7 001201405.2_16129001_3 - 3.6e-17 61.6 1.2 8.9e-17 60.4 1.2 1.8 1 0 0 1 1 1 1 Alpha-macro-globulin thiol-ester bond-forming region A2M_N PF01835.17 001201405.2_16129001_3 - 8.9e-14 51.6 0.1 6e-13 48.9 0.0 2.5 3 0 0 3 3 3 1 MG2 domain SQHop_cyclase_C PF13243.4 001201405.2_16129001_3 - 0.00053 19.0 0.0 0.025 13.5 0.0 2.2 2 0 0 2 2 2 1 Squalene-hopene cyclase C-terminal domain Prenyltrans PF00432.19 001201405.2_16129001_3 - 0.001 18.7 0.0 1.4 8.6 0.0 2.9 2 0 0 2 2 2 2 Prenyltransferase and squalene oxidase repeat Big_1 PF02369.14 001201405.2_16129001_3 - 0.0015 18.4 1.1 0.01 15.7 0.0 3.0 2 0 0 2 2 2 1 Bacterial Ig-like domain (group 1) RIC3 PF15361.4 001002381.1_16123001_3 - 1.8e-33 115.9 0.0 5.2e-33 114.4 0.0 1.7 2 0 0 2 2 2 1 Resistance to inhibitors of cholinesterase homologue 3 RabGAP-TBC PF00566.16 001006076.2_16126001_1 - 2.8e-47 161.0 0.8 4.8e-47 160.3 0.8 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3548 PF12068.6 001006076.2_16126001_1 - 0.00014 21.4 0.1 0.086 12.3 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3548) CAF20 PF17052.3 001006076.2_16126001_1 - 1.9 8.5 4.2 12 5.9 0.3 2.3 2 0 0 2 2 2 0 Cap associated factor Ion_trans PF00520.29 001128725.1_16125001_3 - 1.9e-44 151.6 15.3 2.4e-44 151.3 15.3 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001128725.1_16125001_3 - 3.1e-27 94.6 0.0 7.5e-27 93.4 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain Ion_trans_2 PF07885.14 001128725.1_16125001_3 - 1.5e-11 44.0 9.6 4.5e-11 42.4 2.3 2.6 2 0 0 2 2 2 2 Ion channel BTB_3 PF16017.3 001128725.1_16125001_3 - 0.0078 16.2 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain PKD_channel PF08016.10 001128725.1_16125001_3 - 1.3 7.5 8.4 2.8 6.4 0.7 2.1 1 1 1 2 2 2 0 Polycystin cation channel TMEM144 PF07857.10 001005983.1_16123001_2 - 4.8e-101 338.0 11.2 5.6e-101 337.7 11.2 1.0 1 0 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.10 001005983.1_16123001_2 - 1.9e-09 37.1 7.2 2.8e-08 33.3 2.1 2.4 2 0 0 2 2 2 2 Sugar transport protein GST_N_3 PF13417.4 001007372.1_16122001_3 - 3.2e-21 75.4 0.3 9.9e-21 73.8 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 001007372.1_16122001_3 - 3.4e-17 62.4 0.0 6e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.18 001007372.1_16122001_3 - 1.4e-14 54.0 0.0 2.8e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001007372.1_16122001_3 - 1.9e-08 34.2 0.1 3.2e-08 33.6 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 001007372.1_16122001_3 - 4.2e-07 29.7 0.0 6.6e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 001007372.1_16122001_3 - 7.5e-07 29.1 0.1 1.3e-06 28.4 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.22 001007372.1_16122001_3 - 0.00054 20.0 0.0 0.0011 19.1 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin Pkinase PF00069.23 001045189.2_16128001_1 - 5.6e-25 88.1 1.3 8.8e-25 87.4 1.3 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001045189.2_16128001_1 - 2.2e-24 86.0 1.2 3.6e-24 85.3 1.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PRESAN PF09687.8 001045189.2_16128001_1 - 0.098 13.1 8.1 0.24 11.8 8.1 1.6 1 0 0 1 1 1 0 Plasmodium RESA N-terminal CUE PF02845.14 199690.2_16124001_1 - 4.6e-09 35.7 0.1 8.3e-09 34.9 0.1 1.4 1 0 0 1 1 1 1 CUE domain Acyltransferase PF01553.19 199690.2_16124001_1 - 0.049 13.1 0.2 0.45 10.0 0.1 2.5 2 1 0 2 2 2 0 Acyltransferase E3_UbLigase_EDD PF11547.6 199690.2_16124001_1 - 0.077 12.6 0.3 0.16 11.6 0.3 1.4 1 0 0 1 1 1 0 E3 ubiquitin ligase EDD ETRAMP PF09716.8 199690.2_16124001_2 - 0.041 13.8 0.2 0.13 12.3 0.2 1.8 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Myb_DNA-bind_5 PF13873.4 001126405.1_16122001_1 - 4.1e-27 93.9 6.6 8.9e-27 92.9 6.6 1.6 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.7 001126405.1_16122001_1 - 0.00012 22.1 1.0 0.00022 21.3 0.1 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Peptidase_S68 PF10461.7 001126405.1_16122001_1 - 0.043 13.9 0.0 0.13 12.4 0.0 1.8 1 0 0 1 1 1 0 Peptidase S68 Lipoprotein_7 PF01540.14 001126405.1_16122001_1 - 0.058 12.5 2.6 0.11 11.6 2.6 1.4 1 0 0 1 1 1 0 Adhesin lipoprotein Type_III_YscX PF09474.8 001126405.1_16122001_1 - 0.11 12.7 2.4 0.14 12.3 0.5 2.1 1 1 1 2 2 2 0 Type III secretion system YscX (type_III_YscX) Myb_DNA-bind_3 PF12776.5 001126405.1_16122001_1 - 0.26 12.0 3.7 0.2 12.4 0.5 2.3 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain TBCA PF02970.14 001126405.1_16122001_1 - 1.6 9.0 7.4 0.2 11.9 1.1 2.4 2 2 0 2 2 2 0 Tubulin binding cofactor A DUF2993 PF11209.6 001327856.1_16129001_1 - 0.0011 19.0 8.7 3.6 7.5 0.0 6.4 6 0 0 6 6 6 4 Protein of unknown function (DUF2993) OAD_gamma PF04277.11 200971.1_16125001_1 - 4.9 7.7 5.0 7.6 7.1 5.0 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain G-alpha PF00503.18 200971.1_16125001_3 - 4e-122 407.7 2.4 5.1e-122 407.3 2.4 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 200971.1_16125001_3 - 5.5e-17 61.6 0.3 1.2e-12 47.5 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 200971.1_16125001_3 - 8.1e-05 22.0 2.7 0.0077 15.5 0.9 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 200971.1_16125001_3 - 0.0015 18.6 0.3 2.4 8.3 0.1 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase DSPn PF14671.4 201149.1_16125001_2 - 1.1e-62 210.5 3.1 4e-62 208.7 2.3 2.1 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.18 201149.1_16125001_2 - 6.2e-14 51.8 0.0 1.3e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 201149.1_16125001_2 - 0.00035 20.1 0.0 0.00061 19.3 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.4 201149.1_16125001_2 - 0.005 16.8 0.0 0.01 15.8 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.4 201149.1_16125001_2 - 0.1 12.4 0.2 0.17 11.7 0.2 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF1925 PF09094.9 201149.1_16125001_2 - 0.1 12.8 0.3 0.26 11.5 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1925) SSF PF00474.15 001007300.1_16125001_2 - 4.2e-144 480.2 24.0 6.9e-144 479.5 24.0 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family Spore_permease PF03845.11 001007300.1_16125001_2 - 0.00023 19.9 12.0 0.00023 19.9 12.0 2.9 4 0 0 4 4 4 1 Spore germination protein TMCCDC2 PF15844.3 001007300.1_16125001_2 - 0.05 13.4 0.0 0.05 13.4 0.0 3.2 4 0 0 4 4 4 0 Transmembrane and coiled-coil domain-containing protein 2 DUF4231 PF14015.4 001007300.1_16125001_2 - 0.44 10.9 2.9 2 8.8 0.4 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) DUF4131 PF13567.4 001007300.1_16125001_2 - 2.3 7.7 0.0 2.3 7.7 0.0 4.5 3 1 1 5 5 5 0 Domain of unknown function (DUF4131) DUF2267 PF10025.7 001002545.2_16123001_1 - 0.032 14.4 1.0 0.053 13.7 1.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) EF-hand_1 PF00036.30 213212.1_16126001_3 - 1.3e-14 52.4 9.9 9.8e-07 27.8 1.6 3.8 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 213212.1_16126001_3 - 4.4e-13 49.4 5.8 6.9e-06 26.3 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 213212.1_16126001_3 - 1e-10 40.5 9.1 6.2e-07 28.7 0.9 3.1 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.4 213212.1_16126001_3 - 1.3e-06 27.9 7.9 0.0013 18.3 0.3 3.3 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 213212.1_16126001_3 - 5.6e-06 25.5 2.2 0.00012 21.3 1.5 2.6 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.9 213212.1_16126001_3 - 0.0046 17.7 0.0 0.0088 16.8 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain GPHH PF16905.3 213212.1_16126001_3 - 0.14 11.9 0.0 7.5 6.3 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated FAD_binding_1 PF00667.18 001320439.1_16127001_2 - 1.1e-80 270.3 0.0 1.5e-80 269.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 001320439.1_16127001_2 - 6.8e-36 123.5 0.7 1.4e-35 122.5 0.7 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.19 001320439.1_16127001_2 - 9e-19 68.0 0.2 4.6e-18 65.7 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Iso_dh PF00180.18 200951.2_16123001_3 - 1.2e-111 373.2 0.0 1.4e-111 372.9 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Pkinase PF00069.23 001135043.2_16124001_2 - 1.3e-78 263.8 0.0 1.7e-78 263.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001135043.2_16124001_2 - 8.5e-37 126.7 0.0 1.3e-36 126.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001135043.2_16124001_2 - 4.9e-09 35.8 0.0 8.8e-08 31.7 0.0 2.2 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.12 001135043.2_16124001_2 - 0.00093 18.5 0.0 0.0016 17.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001135043.2_16124001_2 - 0.011 15.5 0.0 0.28 10.9 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.4 001135043.2_16124001_2 - 0.023 14.2 0.1 1 8.8 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.20 001135043.2_16124001_2 - 0.051 13.0 0.1 0.1 12.0 0.1 1.4 1 0 0 1 1 1 0 RIO1 family Tyrosinase PF00264.18 001135043.2_16124001_2 - 0.081 13.1 0.1 0.13 12.3 0.1 1.3 1 0 0 1 1 1 0 Common central domain of tyrosinase 5_nucleotid PF05761.12 001135043.2_16124001_2 - 0.09 11.5 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 5' nucleotidase family PDZ PF00595.22 001126427.1_16124001_1 - 4.8e-14 52.3 0.7 8.6e-14 51.5 0.7 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001126427.1_16124001_1 - 0.002 18.3 0.1 0.0046 17.1 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PH PF00169.27 001126427.1_16124001_1 - 0.021 15.2 0.2 4.9 7.6 0.0 2.8 3 0 0 3 3 3 0 PH domain REV PF00424.16 001126427.1_16124001_1 - 0.036 13.9 0.5 0.085 12.8 0.5 1.5 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) Tricorn_PDZ PF14685.4 001126427.1_16124001_1 - 0.067 13.1 0.3 0.87 9.5 0.0 2.5 2 0 0 2 2 2 0 Tricorn protease PDZ domain Cystatin PF00031.19 001128706.1_16122001_2 - 4.2e-10 39.6 0.7 5.8e-10 39.2 0.7 1.1 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.3 001128706.1_16122001_2 - 0.0054 16.9 0.4 0.0079 16.4 0.4 1.3 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor COesterase PF00135.26 001166331.1_16125001_1 - 5.6e-195 649.0 0.0 7.1e-195 648.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001166331.1_16125001_1 - 2.3e-07 30.7 0.1 1.6e-06 28.0 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ras PF00071.20 001145705.1_16122001_1 - 5.8e-57 191.7 0.0 6.6e-57 191.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001145705.1_16122001_1 - 2.6e-20 72.7 0.0 3.6e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001145705.1_16122001_1 - 3.9e-10 39.3 0.0 4.2e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 001145705.1_16122001_1 - 2e-07 30.9 0.1 0.00036 20.3 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001145705.1_16122001_1 - 4.6e-06 26.2 0.2 3.3e-05 23.4 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001145705.1_16122001_1 - 0.00036 20.5 0.0 0.00052 20.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001145705.1_16122001_1 - 0.0021 17.5 0.1 0.0082 15.5 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.3 001145705.1_16122001_1 - 0.006 16.5 0.0 0.009 15.9 0.0 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TPP_enzyme_M PF00205.20 001145705.1_16122001_1 - 0.0073 15.9 0.0 0.018 14.7 0.0 1.6 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain AAA_25 PF13481.4 001145705.1_16122001_1 - 0.054 12.9 0.0 2.3 7.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain ArgK PF03308.14 001145705.1_16122001_1 - 0.089 11.6 0.1 1.6 7.5 0.0 2.2 2 0 0 2 2 2 0 ArgK protein DEAD PF00270.27 001128715.1_16124001_1 - 8.1e-27 94.0 0.0 1.6e-26 93.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001128715.1_16124001_1 - 4.3e-26 91.3 0.0 1.1e-25 90.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 001128715.1_16124001_1 - 0.011 15.6 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.4 001128715.1_16124001_1 - 0.083 12.9 0.0 0.2 11.7 0.0 1.6 1 1 1 2 2 2 0 Helicase C-terminal domain DUF846 PF05832.10 001024428.1_16123001_2 - 1.5e-54 183.7 8.0 2e-54 183.3 8.0 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) gpUL132 PF11359.6 001024428.1_16123001_2 - 0.19 11.1 0.4 0.37 10.2 0.1 1.4 1 1 0 1 1 1 0 Glycoprotein UL132 adh_short PF00106.23 001144042.1_16123001_1 - 5.4e-32 110.7 0.1 8.2e-32 110.1 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001144042.1_16123001_1 - 3.1e-23 82.4 0.0 4.6e-23 81.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001144042.1_16123001_1 - 4.6e-09 36.3 0.2 6.7e-09 35.8 0.2 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.4 001144042.1_16123001_1 - 0.0039 17.0 0.1 0.0061 16.4 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.10 001144042.1_16123001_1 - 0.08 12.0 0.0 0.18 10.8 0.0 1.6 1 1 1 2 2 2 0 Male sterility protein DAO PF01266.22 001287088.1_16123001_2 - 2.7e-37 129.0 0.0 3.3e-37 128.7 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.15 001287088.1_16123001_2 - 0.0022 17.1 0.0 0.0032 16.6 0.0 1.2 1 0 0 1 1 1 1 Thi4 family UDPG_MGDP_dh_N PF03721.12 001287088.1_16123001_2 - 0.084 12.3 0.6 0.12 11.8 0.6 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_2 PF07992.12 001287088.1_16123001_2 - 0.085 11.9 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.19 001287088.1_16123001_2 - 0.094 11.9 0.1 0.15 11.2 0.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.4 001287088.1_16123001_2 - 0.1 12.9 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF4954 PF16314.3 001287088.1_16123001_2 - 0.19 9.7 0.0 0.27 9.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) IER PF05760.10 199754.1_16125001_3 - 4.1e-125 418.2 5.9 5.2e-125 417.9 5.9 1.1 1 0 0 1 1 1 1 Immediate early response protein (IER) Clathrin PF00637.18 199754.1_16125001_3 - 0.034 13.9 0.7 0.061 13.0 0.7 1.3 1 0 0 1 1 1 0 Region in Clathrin and VPS Macro PF01661.19 001004573.2_16125001_1 - 3.6e-41 139.8 0.1 5.4e-41 139.2 0.1 1.3 1 0 0 1 1 1 1 Macro domain zf-C4 PF00105.16 001277094.2_16125001_1 - 1.1e-32 112.1 13.7 2.6e-32 110.9 13.7 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001277094.2_16125001_1 - 1.7e-27 96.3 5.9 3.1e-27 95.4 5.9 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor HSP70 PF00012.18 201326.2_16127001_1 - 1.2e-267 888.8 12.0 1.5e-267 888.6 12.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 201326.2_16127001_1 - 1.8e-14 53.1 1.1 4.4e-12 45.3 0.2 2.7 2 1 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.14 201326.2_16127001_1 - 1.7e-05 24.5 0.1 4.8e-05 23.0 0.0 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.4 201326.2_16127001_1 - 0.0066 16.7 2.8 4 7.8 0.1 3.8 3 2 0 3 3 3 2 Cell division protein FtsA Calponin PF00402.16 199753.1_16124001_3 - 6.4e-45 150.3 17.9 2.4e-16 58.9 1.8 3.5 3 0 0 3 3 3 3 Calponin family repeat CH PF00307.29 199753.1_16124001_3 - 2.6e-21 75.7 0.2 4.4e-21 75.0 0.2 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 199753.1_16124001_3 - 0.081 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 CAMSAP CH domain DSPc PF00782.18 199774.3_16127001_3 - 2.1e-42 143.9 0.0 3.1e-42 143.4 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.18 199774.3_16127001_3 - 5.1e-10 39.7 0.0 8.4e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain Y_phosphatase PF00102.25 199774.3_16127001_3 - 0.0014 18.1 0.0 0.0022 17.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.10 199774.3_16127001_3 - 0.026 14.7 0.0 0.055 13.6 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain PTPlike_phytase PF14566.4 199774.3_16127001_3 - 0.097 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate Sugar_tr PF00083.22 001083861.1_16125001_3 - 5.8e-37 127.5 16.9 7.9e-37 127.0 16.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001083861.1_16125001_3 - 4.6e-32 111.2 16.4 6.9e-32 110.6 16.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.11 001083861.1_16125001_3 - 0.00069 18.0 4.3 0.0012 17.3 4.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PDGF_N PF04692.11 001076757.1_16124001_2 - 1.2e-30 106.1 3.0 1.2e-30 106.1 3.0 2.4 3 0 0 3 3 3 1 Platelet-derived growth factor, N terminal region PDGF PF00341.15 001076757.1_16124001_2 - 1.3e-19 70.2 8.4 3.1e-19 68.9 8.4 1.7 1 0 0 1 1 1 1 PDGF/VEGF domain Troponin PF00992.18 001008613.1_16122001_2 - 2.4e-46 157.2 11.1 2.4e-46 157.2 11.1 1.8 3 0 0 3 3 3 1 Troponin BSMAP PF12280.6 001111188.1_16124001_2 - 8.5e-76 254.1 0.7 8.5e-76 254.1 0.7 2.7 3 0 0 3 3 3 1 Brain specific membrane anchored protein Peptidase_S49_N PF08496.8 001111188.1_16124001_3 - 0.89 9.5 6.3 1.2 9.0 6.3 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PCM1_C PF15717.3 001115123.1_16129001_2 - 2.4e-268 891.9 43.7 2.4e-268 891.9 43.7 4.6 5 0 0 5 5 5 1 Pericentriolar material 1 C terminus F-actin_cap_A PF01267.15 001006663.1_16125001_1 - 3.5e-106 354.4 0.3 4.3e-106 354.1 0.3 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit RRM_1 PF00076.20 001114686.2_16129001_3 - 2.8e-37 126.2 0.3 8.8e-15 54.2 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001114686.2_16129001_3 - 0.00024 21.0 0.1 0.26 11.3 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif RRM_5 PF13893.4 001114686.2_16129001_3 - 0.00027 20.4 0.0 0.017 14.6 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 001114686.2_16129001_3 - 0.02 14.8 0.1 0.096 12.6 0.0 2.1 3 0 0 3 3 3 0 Limkain b1 DUF4538 PF15061.4 001302624.1_16122001_1 - 2.2e-25 88.0 0.0 3.1e-25 87.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4538) Sulfotransfer_1 PF00685.25 001078168.2_16126001_2 - 3.3e-72 243.0 0.0 4.2e-72 242.7 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001078168.2_16126001_2 - 1.8e-09 38.2 0.0 1.9e-06 28.3 0.0 2.1 2 0 0 2 2 2 2 Sulfotransferase family CART PF06373.9 001327818.1_16122001_1 - 2.6e-36 123.5 2.5 5.2e-36 122.5 2.5 1.5 1 0 0 1 1 1 1 Cocaine and amphetamine regulated transcript protein (CART) NARG2_C PF10505.7 001327818.1_16122001_1 - 0.02 14.3 0.0 0.03 13.7 0.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated gene protein 2 C-terminus Epimerase PF01370.19 001003528.1_16129001_3 - 8.1e-52 175.9 0.1 1.1e-51 175.6 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 001003528.1_16129001_3 - 6.3e-11 42.1 0.3 9.9e-11 41.4 0.0 1.3 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.15 001003528.1_16129001_3 - 4.8e-06 25.7 0.0 6.8e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.13 001003528.1_16129001_3 - 0.003 16.6 0.7 0.028 13.4 0.0 2.0 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein Nebulin PF00880.16 001324547.1_16129001_2 - 2.9e-220 710.7 222.6 1.4e-10 40.7 0.3 47.1 47 0 0 47 47 47 45 Nebulin repeat LIM PF00412.20 001324547.1_16129001_2 - 8.6e-10 38.6 5.9 2.1e-09 37.4 5.9 1.6 1 0 0 1 1 1 1 LIM domain c-SKI_SMAD_bind PF08782.8 001324547.1_16129001_2 - 0.043 13.9 0.7 0.19 11.9 0.7 2.1 1 0 0 1 1 1 0 c-SKI Smad4 binding domain U-box PF04564.13 001328062.1_16124001_3 - 5.2e-19 68.1 0.1 1.5e-18 66.6 0.1 1.8 1 0 0 1 1 1 1 U-box domain zf-RING_5 PF14634.4 001328062.1_16124001_3 - 0.00037 20.3 9.2 0.0015 18.3 9.2 2.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.23 001328062.1_16124001_3 - 0.0033 17.1 10.7 0.012 15.3 10.7 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001328062.1_16124001_3 - 0.081 12.8 9.9 0.25 11.2 9.9 2.0 1 0 0 1 1 1 0 RING-type zinc-finger SIX1_SD PF16878.3 131718.2_16125001_1 - 2.2e-48 163.3 0.4 3.8e-47 159.2 0.0 2.2 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeobox PF00046.27 131718.2_16125001_1 - 1.7e-13 50.1 1.0 4.4e-13 48.7 1.0 1.7 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 131718.2_16125001_1 - 1.5e-09 37.5 0.7 3.4e-09 36.3 0.7 1.6 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.3 131718.2_16125001_1 - 0.06 13.1 0.2 7 6.5 0.0 2.5 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Homez PF11569.6 131718.2_16125001_1 - 0.096 12.0 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Adaptin_N PF01602.18 001002013.1_16127001_2 - 4.9e-121 404.7 8.7 7.7e-121 404.1 8.7 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.4 001002013.1_16127001_2 - 5.3e-61 204.1 0.4 6.2e-60 200.7 0.0 2.4 2 0 0 2 2 2 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.10 001002013.1_16127001_2 - 9.6e-61 203.7 0.5 2e-60 202.6 0.5 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region HEAT_2 PF13646.4 001002013.1_16127001_2 - 1.4e-07 31.7 3.4 0.12 12.7 0.0 6.1 4 2 3 7 7 7 2 HEAT repeats Cnd1 PF12717.5 001002013.1_16127001_2 - 3.9e-07 30.1 13.5 9.3e-06 25.6 0.2 4.4 3 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.20 001002013.1_16127001_2 - 1.9e-05 24.4 0.1 2 8.7 0.0 5.1 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.4 001002013.1_16127001_2 - 5.3e-05 23.4 0.5 7.7 7.0 0.0 5.0 5 0 0 5 5 5 2 HEAT-like repeat MMS19_N PF14500.4 001002013.1_16127001_2 - 0.00013 21.5 2.1 0.0013 18.2 0.0 3.2 3 1 1 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II Arm PF00514.21 001002013.1_16127001_2 - 0.011 15.6 0.0 2 8.5 0.0 3.3 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat PP1_inhibitor PF05361.10 001029963.1_16124001_3 - 6.5e-33 113.6 1.9 1.6e-32 112.3 2.2 1.4 2 0 0 2 2 2 1 PKC-activated protein phosphatase-1 inhibitor Zona_pellucida PF00100.21 001109833.1_16123001_1 - 4.3e-35 121.6 0.0 5.4e-35 121.2 0.0 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain RNA_pol_L PF01193.22 001109833.1_16123001_1 - 0.12 11.7 0.0 0.26 10.6 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain RRM_5 PF13893.4 001122654.1_16128001_1 - 7.4e-53 177.3 2.4 1.3e-38 131.3 0.0 4.2 3 1 1 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 001122654.1_16128001_1 - 2.2e-30 104.1 1.0 6.5e-09 35.4 0.1 4.7 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001122654.1_16128001_1 - 2.2e-07 30.5 0.1 5.1 6.9 0.0 4.2 4 0 0 4 4 4 4 Occluded RNA-recognition motif FAD_binding_4 PF01565.21 001347881.1_16129001_2 - 0.16 11.6 0.0 0.28 10.8 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Pkinase_Tyr PF07714.15 001347881.1_16129001_3 - 2.1e-85 286.0 0.0 3.1e-85 285.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase GTPase_binding PF09027.8 001347881.1_16129001_3 - 5e-43 144.8 1.0 1e-42 143.8 1.0 1.5 1 0 0 1 1 1 1 GTPase binding Pkinase PF00069.23 001347881.1_16129001_3 - 4.4e-42 144.1 0.0 9.3e-41 139.8 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Inhibitor_Mig-6 PF11555.6 001347881.1_16129001_3 - 4.2e-31 106.7 10.5 4.2e-31 106.7 10.5 3.1 3 0 0 3 3 3 1 EGFR receptor inhibitor Mig-6 SH3_9 PF14604.4 001347881.1_16129001_3 - 3.8e-09 36.1 0.0 6.8e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001347881.1_16129001_3 - 1.9e-06 27.2 0.1 3.4e-06 26.4 0.1 1.4 1 0 0 1 1 1 1 SH3 domain UBA_4 PF14555.4 001347881.1_16129001_3 - 2.2e-06 27.2 0.1 0.029 14.1 0.0 2.4 2 0 0 2 2 2 2 UBA-like domain Kinase-like PF14531.4 001347881.1_16129001_3 - 7.7e-06 25.3 0.0 1.2e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like SH3_2 PF07653.15 001347881.1_16129001_3 - 0.00066 19.2 0.0 0.0016 18.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain DUF1426 PF07234.9 001347881.1_16129001_3 - 5.4 7.1 5.2 14 5.7 5.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1426) Peptidase_C2 PF00648.19 001013501.2_16125001_2 - 5.3e-126 419.5 0.0 7.4e-126 419.0 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 001013501.2_16125001_2 - 1.1e-53 181.2 0.0 2.6e-53 180.0 0.0 1.7 2 0 0 2 2 2 1 Calpain large subunit, domain III EF-hand_8 PF13833.4 001013501.2_16125001_2 - 2.2e-09 36.8 7.1 4e-09 36.0 0.3 3.5 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.30 001013501.2_16125001_2 - 2.7e-09 35.8 6.1 0.079 12.4 0.0 5.4 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.4 001013501.2_16125001_2 - 7.2e-06 25.4 5.6 2.2 8.3 0.8 5.3 4 1 1 5 5 5 2 EF-hand domain EF-hand_7 PF13499.4 001013501.2_16125001_2 - 0.00023 21.4 3.5 0.54 10.6 0.1 4.3 4 1 0 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.4 001013501.2_16125001_2 - 6.2 6.4 9.5 1 8.9 0.2 3.6 4 0 0 4 4 4 0 EF hand Cystatin PF00031.19 001004512.2_16122001_3 - 1.1e-18 67.1 0.4 1.8e-18 66.5 0.4 1.3 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.3 001004512.2_16122001_3 - 0.001 19.3 0.1 0.0016 18.6 0.1 1.3 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor Cathelicidins PF00666.15 001004512.2_16122001_3 - 0.0084 16.3 0.9 0.014 15.6 0.9 1.3 1 0 0 1 1 1 1 Cathelicidin Collagen PF01391.16 001302249.1_16127001_1 - 8.6e-68 223.9 311.4 4.2e-09 35.9 27.2 11.8 1 1 9 10 10 10 8 Collagen triple helix repeat (20 copies) VWA PF00092.26 001302249.1_16127001_1 - 7.3e-64 215.1 1.6 4e-37 128.0 0.1 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.4 001302249.1_16127001_1 - 1.8e-25 89.5 0.3 8.1e-15 55.3 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain Kunitz_BPTI PF00014.21 001302249.1_16127001_1 - 4.6e-18 65.1 5.2 1e-17 64.0 5.2 1.6 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain VWA_3 PF13768.4 001302249.1_16127001_1 - 2.6e-08 33.8 0.2 0.00019 21.2 0.0 2.6 3 0 0 3 3 3 2 von Willebrand factor type A domain VWA_CoxE PF05762.12 001302249.1_16127001_1 - 0.0026 17.1 0.3 0.056 12.7 0.0 2.2 2 0 0 2 2 2 1 VWA domain containing CoxE-like protein HMMR_N PF15905.3 199580.2_16127001_3 - 1.7e-116 389.3 72.6 3.9e-116 388.1 35.9 6.0 1 1 5 6 6 6 2 Hyaluronan mediated motility receptor N-terminal HMMR_C PF15908.3 199580.2_16127001_3 - 1.3e-65 220.3 16.2 1.3e-65 220.3 16.2 7.1 2 2 4 7 7 7 1 Hyaluronan mediated motility receptor C-terminal Golgin_A5 PF09787.7 199580.2_16127001_3 - 1.1e-05 25.0 40.2 1.1e-05 25.0 40.2 7.2 1 1 7 8 8 8 1 Golgin subfamily A member 5 TPR_MLP1_2 PF07926.10 199580.2_16127001_3 - 0.0011 19.0 10.6 0.0011 19.0 10.6 9.2 2 1 6 9 9 9 3 TPR/MLP1/MLP2-like protein IncA PF04156.12 199580.2_16127001_3 - 0.0057 16.3 14.8 0.0057 16.3 14.8 8.3 1 1 6 7 7 7 3 IncA protein Reo_sigmaC PF04582.10 199580.2_16127001_3 - 0.014 14.7 46.6 0.074 12.3 5.6 6.3 1 1 3 6 6 6 0 Reovirus sigma C capsid protein Filament PF00038.19 199580.2_16127001_3 - 1.9 7.9 165.5 0.013 15.0 36.3 5.8 1 1 5 6 6 6 0 Intermediate filament protein 7tm_1 PF00001.19 131212.2_16124001_1 - 2.2e-45 154.9 12.4 3.5e-45 154.2 12.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Rhodopsin_N PF10413.7 131212.2_16124001_1 - 1.2e-23 82.4 1.7 2.9e-23 81.2 1.7 1.7 1 0 0 1 1 1 1 Amino terminal of the G-protein receptor rhodopsin 7TM_GPCR_Srv PF10323.7 131212.2_16124001_1 - 9e-10 38.2 13.6 1.6e-09 37.4 13.6 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 131212.2_16124001_1 - 2.2e-07 30.4 11.9 4.1e-07 29.5 11.9 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 131212.2_16124001_1 - 0.0032 17.1 12.0 0.012 15.2 12.0 1.8 1 1 0 1 1 1 1 Olfactory receptor TAS2R PF05296.11 131212.2_16124001_1 - 0.014 14.4 9.6 0.084 11.8 1.1 2.2 2 0 0 2 2 2 0 Taste receptor protein (TAS2R) DUF4407 PF14362.4 131212.2_16124001_1 - 0.29 10.3 1.9 0.69 9.1 1.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Rnf-Nqr PF02508.12 131212.2_16124001_1 - 0.61 9.9 9.9 0.29 11.0 3.4 2.9 1 1 2 3 3 3 0 Rnf-Nqr subunit, membrane protein DUF1003 PF06210.9 131212.2_16124001_1 - 6.4 6.8 10.5 1.3 9.1 3.7 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF1003) HEAT_2 PF13646.4 173267.1_16126001_3 - 0.031 14.5 3.5 30 5.0 0.0 4.4 3 1 2 5 5 5 0 HEAT repeats Gal_Lectin PF02140.16 001109720.1_16122001_1 - 1.1e-27 96.1 4.8 9.9e-24 83.5 0.8 2.3 2 0 0 2 2 2 2 Galactose binding lectin domain DUF3395 PF11875.6 001109720.1_16122001_1 - 0.1 12.4 0.0 0.25 11.1 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3395) T-box PF00907.20 001328433.1_16127001_2 - 6.7e-78 261.0 0.0 9.2e-78 260.5 0.0 1.2 1 0 0 1 1 1 1 T-box LRR_8 PF13855.4 131713.2_16124001_3 - 2.5e-35 119.9 14.0 1.1e-11 44.1 5.9 4.5 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 131713.2_16124001_3 - 1.1e-16 60.5 18.6 0.0044 17.2 0.1 5.6 4 1 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 131713.2_16124001_3 - 5e-09 36.1 0.0 1.8e-05 24.5 0.0 2.7 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRRNT PF01462.16 131713.2_16124001_3 - 1.1e-08 34.4 10.7 1.1e-07 31.1 4.0 3.3 3 0 0 3 3 3 2 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 131713.2_16124001_3 - 4.7e-07 29.3 8.7 0.0043 16.4 0.1 3.0 2 1 0 2 2 2 2 Leucine-rich repeat Osteopontin PF00865.16 131713.2_16124001_3 - 2.4 7.4 14.8 3.6 6.9 14.8 1.1 1 0 0 1 1 1 0 Osteopontin P2X_receptor PF00864.17 198982.1_16123001_1 - 9e-152 505.2 1.5 1e-151 505.0 1.5 1.0 1 0 0 1 1 1 1 ATP P2X receptor TRAPP PF04051.14 200661.1_16123001_1 - 5.4e-44 149.3 0.2 7.1e-44 148.9 0.2 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Helo_like_N PF17111.3 001045462.2_16124001_3 - 0.02 14.2 4.0 1.6 7.9 0.6 2.5 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins PspA_IM30 PF04012.10 001045462.2_16124001_3 - 0.032 13.7 0.8 0.032 13.7 0.8 3.3 3 1 1 4 4 4 0 PspA/IM30 family Laminin_II PF06009.10 001045462.2_16124001_3 - 0.069 13.0 3.3 7.2 6.5 0.3 2.7 3 0 0 3 3 3 0 Laminin Domain II DUF2730 PF10805.6 001045462.2_16124001_3 - 0.16 12.0 2.5 3.3 7.7 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) KxDL PF10241.7 001045462.2_16124001_3 - 9.5 6.4 8.1 3.6 7.8 0.4 3.2 2 1 1 3 3 3 0 Uncharacterized conserved protein Ion_trans PF00520.29 001126470.1_16124001_1 - 2.4e-43 148.0 12.4 3.2e-43 147.6 12.4 1.1 1 0 0 1 1 1 1 Ion transport protein DUF3399 PF11879.6 001126470.1_16124001_1 - 1.2e-39 134.6 7.1 2.9e-39 133.5 7.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3399) BTB_2 PF02214.20 001126470.1_16124001_1 - 1.3e-30 105.5 0.6 3.6e-30 104.0 0.1 2.0 2 0 0 2 2 2 1 BTB/POZ domain Shal-type PF11601.6 001126470.1_16124001_1 - 1.6e-14 53.0 7.6 3.2e-14 52.0 7.6 1.5 1 0 0 1 1 1 1 Shal-type voltage-gated potassium channels, N-terminal Ion_trans_2 PF07885.14 001126470.1_16124001_1 - 6.6e-13 48.3 7.0 6.6e-13 48.3 7.0 2.5 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.3 001126470.1_16124001_1 - 1.6e-05 24.8 0.0 0.00027 20.9 0.0 2.5 2 0 0 2 2 2 1 BTB/POZ domain PKD_channel PF08016.10 001126470.1_16124001_1 - 0.00045 18.9 3.4 0.00045 18.9 3.4 1.6 1 1 1 2 2 2 1 Polycystin cation channel HRCT1 PF15758.3 001126470.1_16124001_1 - 0.2 12.5 5.9 0.49 11.3 5.9 1.6 1 0 0 1 1 1 0 Histidine-rich carboxyl terminus protein 1 FSA_C PF10479.7 001145584.1_16129001_1 - 3.6e-162 540.9 7.6 3.5e-128 428.6 1.7 2.5 1 1 1 2 2 2 2 Fragile site-associated protein C-terminus Kinesin PF00225.21 001017849.2_16126001_1 - 1.2e-116 389.2 0.6 1.2e-116 389.2 0.6 1.6 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.3 001017849.2_16126001_1 - 1.5e-26 93.0 0.1 1.5e-26 93.0 0.1 2.0 2 0 0 2 2 2 1 Microtubule binding Kinesin_assoc PF16183.3 001017849.2_16126001_1 - 0.00014 21.9 5.4 0.00016 21.8 3.6 1.9 1 1 0 1 1 1 1 Kinesin-associated NUDIX PF00293.26 001017849.2_16126001_1 - 0.099 12.6 0.4 0.23 11.4 0.4 1.6 1 0 0 1 1 1 0 NUDIX domain Tup_N PF08581.8 001017849.2_16126001_1 - 0.35 11.1 18.7 0.25 11.5 4.7 3.3 3 1 0 3 3 3 0 Tup N-terminal S1 PF00575.21 200544.2_16123001_2 - 1.2e-12 47.8 0.3 2.6e-12 46.8 0.3 1.4 1 0 0 1 1 1 1 S1 RNA binding domain Rtf2 PF04641.10 200544.2_16123001_2 - 0.0036 16.6 17.6 0.0054 16.0 17.6 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger zf-CCHC PF00098.21 200544.2_16123001_2 - 0.015 15.2 6.1 0.036 14.0 6.1 1.6 1 0 0 1 1 1 0 Zinc knuckle DDHD PF02862.15 200544.2_16123001_2 - 0.039 13.9 3.4 0.052 13.6 3.4 1.2 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.10 200544.2_16123001_2 - 0.99 9.0 14.4 1.3 8.7 14.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.20 200544.2_16123001_2 - 1.8 7.6 8.0 2.4 7.2 8.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter zf-CCHC_5 PF14787.4 200544.2_16123001_2 - 2.3 7.9 9.8 0.22 11.2 4.2 2.2 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger DUF913 PF06025.10 200544.2_16123001_2 - 2.6 6.8 6.9 3.6 6.3 6.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) BPL_N PF09825.7 200544.2_16123001_2 - 2.9 6.8 6.3 3.8 6.3 6.3 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal CDC45 PF02724.12 200544.2_16123001_2 - 7.9 4.5 16.1 11 4.1 16.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.8 200544.2_16123001_2 - 8.5 6.5 23.3 13 5.9 23.3 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 G-alpha PF00503.18 001013277.2_16129001_1 - 4.7e-104 348.2 4.3 6e-104 347.9 4.3 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 001013277.2_16129001_1 - 6.5e-12 45.1 1.9 3.1e-09 36.4 0.4 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family adh_short PF00106.23 001017731.1_16122001_2 - 1.7e-27 96.0 0.0 3.1e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001017731.1_16122001_2 - 1.1e-22 80.7 0.0 1.6e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001017731.1_16122001_2 - 3.1e-10 40.1 0.0 4.3e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 KR domain NmrA PF05368.11 001017731.1_16122001_2 - 0.0071 15.8 0.0 0.0096 15.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family FSIP2 PF15783.3 001017731.1_16122001_2 - 0.028 12.2 0.0 0.036 11.9 0.0 1.1 1 0 0 1 1 1 0 Fibrous sheath-interacting protein 2 NAD_binding_10 PF13460.4 001017731.1_16122001_2 - 0.089 12.6 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H-binding GDP_Man_Dehyd PF16363.3 001017731.1_16122001_2 - 0.13 11.5 0.0 0.45 9.7 0.0 1.9 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase 7tm_1 PF00001.19 001285535.1_16123001_2 - 2.9e-20 72.5 13.1 4e-20 72.0 13.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001285535.1_16123001_2 - 0.0051 16.1 5.9 0.0065 15.7 5.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv DUF3099 PF11298.6 001285535.1_16123001_2 - 0.89 9.6 3.9 1.5 8.9 1.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3099) Serpentine_r_xa PF03383.13 001285535.1_16123001_2 - 3.6 7.4 7.6 0.75 9.6 0.1 2.6 2 1 1 3 3 3 0 Caenorhabditis serpentine receptor-like protein, class xa PAC2 PF09754.7 213032.1_16123001_3 - 5.4e-33 114.6 0.0 7e-33 114.3 0.0 1.1 1 0 0 1 1 1 1 PAC2 family T7SS_ESX_EspC PF10824.6 213032.1_16123001_3 - 0.12 12.8 0.1 19 5.7 0.0 2.1 2 0 0 2 2 2 0 Excreted virulence factor EspC, type VII ESX diderm IRK PF01007.18 201035.1_16124001_2 - 7.7e-129 429.2 0.2 1e-128 428.8 0.2 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 201035.1_16124001_2 - 2e-05 24.4 3.2 6.4e-05 22.7 3.2 1.9 1 0 0 1 1 1 1 Ion channel cNMP_binding PF00027.27 001076623.1_16123001_3 - 2.8e-42 142.5 0.1 4.4e-20 71.4 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.15 001076623.1_16123001_3 - 1.1e-13 50.4 0.1 2.2e-13 49.5 0.1 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Pmp3 PF01679.15 205639.1_16125001_1 - 0.45 10.6 3.0 16 5.6 0.1 2.4 2 0 0 2 2 2 0 Proteolipid membrane potential modulator TPR_2 PF07719.15 205639.1_16125001_2 - 3.6e-18 64.0 5.5 0.043 13.8 0.1 7.8 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.26 205639.1_16125001_2 - 3.2e-16 58.3 2.9 0.063 13.0 0.0 7.6 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.4 205639.1_16125001_2 - 8.4e-10 38.7 6.3 0.17 12.1 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.4 205639.1_16125001_2 - 8.9e-08 31.6 0.6 0.23 11.7 0.0 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.4 205639.1_16125001_2 - 8.6e-06 26.0 14.2 0.45 11.3 0.1 7.2 6 2 2 8 8 7 2 Tetratricopeptide repeat TPR_19 PF14559.4 205639.1_16125001_2 - 3.2e-05 24.2 4.4 0.018 15.4 0.0 5.1 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_16 PF13432.4 205639.1_16125001_2 - 0.00016 22.1 13.4 1.2 9.7 0.4 6.0 5 1 1 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.5 205639.1_16125001_2 - 0.0006 19.8 7.3 4.9 7.3 0.0 5.1 4 1 0 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.4 205639.1_16125001_2 - 0.002 17.8 4.2 0.24 11.2 0.1 5.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_4 PF07721.12 205639.1_16125001_2 - 0.0021 18.3 16.7 0.0088 16.4 2.8 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.4 205639.1_16125001_2 - 0.0071 16.3 1.3 1.5 8.9 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.4 205639.1_16125001_2 - 0.014 15.9 12.7 0.34 11.5 0.1 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.4 205639.1_16125001_2 - 0.032 14.1 5.2 0.65 10.0 0.0 5.2 5 1 1 6 6 6 0 Tetratricopeptide repeat SRP_TPR_like PF17004.3 205639.1_16125001_2 - 0.046 13.6 0.4 13 5.7 0.1 3.6 4 0 0 4 4 4 0 Putative TPR-like repeat TPR_1 PF00515.26 001077321.1_16125001_1 - 1.4e-21 75.2 6.7 1.1e-07 31.2 0.1 5.4 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.15 001077321.1_16125001_1 - 1.7e-19 68.2 9.1 4.2e-05 23.2 0.1 5.4 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_9 PF13371.4 001077321.1_16125001_1 - 3.3e-14 52.7 12.3 1.7e-08 34.4 1.6 4.5 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.4 001077321.1_16125001_1 - 1.2e-10 40.7 3.1 0.0045 17.0 0.0 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 001077321.1_16125001_1 - 2.3e-10 40.3 13.2 0.00043 20.1 0.0 5.3 3 2 2 5 5 5 3 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.4 001077321.1_16125001_1 - 7.7e-07 29.2 15.1 0.036 14.2 0.2 4.5 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_14 PF13428.4 001077321.1_16125001_1 - 8.6e-07 29.1 8.9 0.015 15.9 0.1 5.6 3 3 3 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.4 001077321.1_16125001_1 - 1.4e-05 25.4 8.6 0.077 13.4 0.1 4.2 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.4 001077321.1_16125001_1 - 4.1e-05 24.0 2.5 0.051 14.2 0.8 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.4 001077321.1_16125001_1 - 0.00023 21.2 4.4 17 5.9 0.0 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_10 PF13374.4 001077321.1_16125001_1 - 0.0043 16.8 8.5 0.18 11.6 0.2 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.4 001077321.1_16125001_1 - 0.0043 16.6 3.1 0.31 10.6 0.1 4.0 2 1 2 4 4 4 1 TPR repeat Alkyl_sulf_dimr PF14863.4 001077321.1_16125001_1 - 0.0083 16.5 0.1 0.31 11.4 0.1 2.6 1 1 1 2 2 2 1 Alkyl sulfatase dimerisation SRP_TPR_like PF17004.3 001077321.1_16125001_1 - 0.014 15.3 0.6 0.14 12.0 0.1 2.4 2 0 0 2 2 2 0 Putative TPR-like repeat TPR_7 PF13176.4 001077321.1_16125001_1 - 0.052 13.5 4.1 5 7.3 0.6 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_15 PF13429.4 001077321.1_16125001_1 - 0.067 12.3 6.5 3.7 6.5 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat ANAPC5 PF12862.5 001077321.1_16125001_1 - 0.21 11.6 1.4 0.7 9.9 1.4 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 5 TPR_6 PF13174.4 001077321.1_16125001_1 - 0.5 11.0 6.8 50 4.7 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat Nucleo_P87 PF07267.9 001077321.1_16125001_2 - 3.9 6.1 9.4 5.6 5.6 9.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF1011 PF06237.10 199656.1_16124001_3 - 2.7e-38 130.1 7.7 2.7e-38 130.1 7.7 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF1011) NIDO PF06119.12 001327869.1_16124001_2 - 2.3e-16 60.5 0.8 1.8e-15 57.6 0.1 2.5 3 0 0 3 3 3 1 Nidogen-like Dynamin_M PF01031.18 001128524.1_16125001_1 - 2.5e-106 354.9 2.7 2.5e-106 354.9 2.7 1.8 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.21 001128524.1_16125001_1 - 6.4e-56 188.9 0.0 1.6e-55 187.6 0.0 1.7 1 0 0 1 1 1 1 Dynamin family GED PF02212.16 001128524.1_16125001_1 - 7.8e-26 89.9 2.1 7.8e-26 89.9 2.1 2.0 2 0 0 2 2 2 1 Dynamin GTPase effector domain PH PF00169.27 001128524.1_16125001_1 - 1.1e-12 48.3 0.7 2.1e-12 47.4 0.7 1.5 1 0 0 1 1 1 1 PH domain MMR_HSR1 PF01926.21 001128524.1_16125001_1 - 0.0012 18.8 0.0 0.0047 16.9 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.4 001128524.1_16125001_1 - 0.07 13.4 0.1 4.6 7.4 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain COG2 PF06148.9 001128524.1_16125001_1 - 1.4 8.9 6.0 10 6.1 0.1 3.5 4 0 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4604 PF15377.4 212692.1_16125001_1 - 0.0096 16.3 12.3 0.014 15.7 12.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) FimP PF09766.7 212692.1_16125001_3 - 2.8e-126 421.5 7.1 2.8e-126 421.5 7.1 2.4 2 0 0 2 2 2 1 Fms-interacting protein DUF2542 PF10808.6 212692.1_16125001_3 - 0.074 13.4 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2542) Ras PF00071.20 200365.1_16123001_2 - 3.3e-27 94.9 0.0 4.8e-27 94.4 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 200365.1_16123001_2 - 2.7e-08 33.9 0.0 4.5e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 200365.1_16123001_2 - 3.8e-06 26.3 0.0 6.4e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 200365.1_16123001_2 - 0.15 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase EamA PF00892.18 001013563.2_16124001_1 - 5.6e-18 65.3 32.2 1.9e-09 37.7 9.0 2.2 2 0 0 2 2 2 2 EamA-like transporter family ATPase_gene1 PF09527.8 001013563.2_16124001_1 - 4.2 7.5 12.2 2.9 8.0 1.1 3.7 3 0 0 3 3 3 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Pho86 PF11124.6 001013563.2_16124001_1 - 5.8 6.2 6.3 2.1 7.6 1.0 2.1 2 0 0 2 2 2 0 Inorganic phosphate transporter Pho86 RNA_pol_3_Rpc31 PF11705.6 001005959.1_16123001_1 - 1.6e-33 116.7 13.9 2.3e-33 116.3 13.9 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Pox_Ag35 PF03286.12 001005959.1_16123001_1 - 0.42 10.2 14.2 0.63 9.7 14.2 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RINT1_TIP1 PF04437.11 001045003.2_16125001_2 - 1.5e-141 472.6 2.5 1.8e-140 469.1 0.1 2.2 2 0 0 2 2 2 2 RINT-1 / TIP-1 family Syntaxin_2 PF14523.4 001045003.2_16125001_2 - 1.5 9.1 8.5 15 5.9 3.3 3.2 2 1 0 2 2 2 0 Syntaxin-like protein Glyco_transf_21 PF13506.4 001024207.2_16126001_1 - 1.3e-58 197.2 0.0 2e-58 196.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.4 001024207.2_16126001_1 - 2.6e-22 79.8 0.0 3.8e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.4 001024207.2_16126001_1 - 1.6e-10 41.1 2.1 1.6e-10 41.1 2.1 1.7 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.24 001024207.2_16126001_1 - 0.036 13.7 0.0 0.064 12.9 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 2 V-set_2 PF15910.3 001024207.2_16126001_2 - 0.031 14.2 0.1 0.064 13.2 0.1 1.4 1 0 0 1 1 1 0 ICOS V-set domain FTHFS PF01268.17 001242996.1_16129001_3 - 3.5e-256 850.6 0.0 4.3e-256 850.3 0.0 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH PF00763.21 001242996.1_16129001_3 - 3.7e-18 65.8 0.0 6.7e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.17 001242996.1_16129001_3 - 4.2e-15 55.3 0.3 1.3e-14 53.7 0.0 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TatD_DNase PF01026.19 001002213.1_16123001_1 - 1.1e-54 185.4 0.0 1.4e-54 185.0 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase SR-25 PF10500.7 001002213.1_16123001_2 - 0.058 12.9 16.1 0.12 11.9 16.1 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Aldolase_II PF00596.19 001002213.1_16123001_2 - 0.61 9.9 3.9 0.99 9.2 3.9 1.3 1 0 0 1 1 1 0 Class II Aldolase and Adducin N-terminal domain PARP PF00644.18 001045019.3_16126001_1 - 1.8e-32 112.6 1.5 2.8e-31 108.7 0.5 2.8 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.18 001045019.3_16126001_1 - 5e-15 55.7 0.5 1.3e-09 38.3 0.2 2.6 2 0 0 2 2 2 2 WWE domain Torus PF16131.3 001045019.3_16126001_1 - 0.012 16.2 0.0 0.024 15.2 0.0 1.5 1 0 0 1 1 1 0 Torus domain p53-inducible11 PF14936.4 001013352.2_16125001_2 - 6.9e-80 267.2 1.9 9.3e-80 266.8 1.9 1.2 1 0 0 1 1 1 1 Tumour protein p53-inducible protein 11 DUF4345 PF14248.4 001013352.2_16125001_2 - 0.0086 15.8 9.2 0.021 14.6 9.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4345) CN_hydrolase PF00795.20 001004638.1_16123001_2 - 1.2e-65 221.4 0.0 1.4e-65 221.1 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase CH PF00307.29 001100101.1_16123001_2 - 8.2e-28 96.6 0.2 8.3e-16 58.0 0.0 2.9 3 0 0 3 3 3 2 Calponin homology (CH) domain F_actin_cap_B PF01115.15 001100101.1_16123001_2 - 0.03 13.9 0.2 0.05 13.1 0.2 1.3 1 0 0 1 1 1 0 F-actin capping protein, beta subunit CAMSAP_CH PF11971.6 001100101.1_16123001_2 - 0.1 12.3 0.0 3.5 7.4 0.0 2.3 2 0 0 2 2 2 0 CAMSAP CH domain CH PF00307.29 001100101.1_16123001_3 - 0.0023 18.0 0.1 1.3 9.1 0.0 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain DLEU7 PF15760.3 001278811.1_16122001_1 - 4.8e-10 39.1 0.0 6e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 Leukemia-associated protein 7 Mustang PF15682.3 001326444.1_16122001_2 - 2.6e-26 91.4 1.6 5.5e-26 90.3 1.6 1.5 1 0 0 1 1 1 1 Musculoskeletal, temporally activated-embryonic nuclear protein 1 Sel1 PF08238.10 001045164.1_16128001_2 - 8.3e-60 197.7 36.9 2.9e-09 37.2 0.5 12.1 12 0 0 12 12 12 10 Sel1 repeat fn2 PF00040.17 001045164.1_16128001_2 - 2.1e-18 66.2 6.0 4.1e-18 65.2 6.0 1.5 1 0 0 1 1 1 1 Fibronectin type II domain ELL PF10390.7 001083812.2_16129001_1 - 4.3e-102 341.2 0.1 4.3e-102 341.2 0.1 2.0 2 0 0 2 2 2 1 RNA polymerase II elongation factor ELL Occludin_ELL PF07303.11 001083812.2_16129001_1 - 2.2e-32 111.6 9.3 2.2e-32 111.6 9.3 2.3 2 0 0 2 2 2 1 Occludin homology domain MIP-T3 PF10243.7 001083812.2_16129001_1 - 0.2 10.2 22.8 0.38 9.3 22.8 1.5 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CDC45 PF02724.12 001083812.2_16129001_1 - 7.6 4.6 14.9 11 4.0 14.9 1.1 1 0 0 1 1 1 0 CDC45-like protein S-methyl_trans PF02574.14 001114888.1_16124001_3 - 3.9e-76 256.3 0.0 5e-76 255.9 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Flavokinase PF01687.15 001328083.1_16129001_3 - 3e-34 117.5 0.0 5.1e-34 116.8 0.0 1.3 1 0 0 1 1 1 1 Riboflavin kinase ApoB100_C PF12491.6 001114566.1_16123001_3 - 0.035 13.9 0.7 0.035 13.9 0.7 2.8 2 0 0 2 2 2 0 Apolipoprotein B100 C terminal Mod_r PF07200.11 001114566.1_16123001_3 - 1.9 8.5 62.7 0.24 11.4 13.8 4.1 1 1 3 4 4 4 0 Modifier of rudimentary (Mod(r)) protein DUF3037 PF11236.6 001114566.1_16123001_3 - 3.9 7.8 24.1 1.4 9.2 2.5 4.1 1 1 4 5 5 5 0 Protein of unknown function (DUF3037) ANAPC4_WD40 PF12894.5 001003758.1_16124001_2 - 2e-26 92.0 0.3 5.9e-05 23.2 0.0 6.7 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 001003758.1_16124001_2 - 4.6e-25 87.3 11.8 4.4e-05 24.0 0.2 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.9 001003758.1_16124001_2 - 7.8e-12 45.3 5.3 6.5e-06 26.0 0.2 2.8 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.10 001003758.1_16124001_2 - 1.2e-06 28.1 0.0 0.021 14.6 0.0 4.2 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Nup160 PF11715.6 001003758.1_16124001_2 - 0.004 15.7 0.1 0.011 14.2 0.0 1.7 2 0 0 2 2 2 1 Nucleoporin Nup120/160 Peptidase_S9_N PF02897.13 001003758.1_16124001_2 - 0.0043 15.8 3.2 1.6 7.3 0.2 3.2 2 1 1 3 3 3 2 Prolyl oligopeptidase, N-terminal beta-propeller domain Me-amine-dh_H PF06433.9 001003758.1_16124001_2 - 0.049 12.4 0.0 3.6 6.2 0.0 2.3 2 0 0 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) PQQ_2 PF13360.4 001003758.1_16124001_2 - 0.057 12.9 0.0 8.3 5.8 0.0 2.2 2 0 0 2 2 2 0 PQQ-like domain DUF4613 PF15390.4 001003758.1_16124001_2 - 0.095 10.9 1.5 0.1 10.8 0.3 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4613) Cytochrom_D1 PF02239.14 001003758.1_16124001_2 - 0.11 10.9 0.0 0.21 9.9 0.0 1.4 1 0 0 1 1 1 0 Cytochrome D1 heme domain Glycos_transf_2 PF00535.24 001003596.1_16123001_1 - 8.6e-37 126.4 0.0 1.1e-36 126.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.4 001003596.1_16123001_1 - 1.2e-10 41.6 0.0 2.2e-10 40.7 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.7 001003596.1_16123001_1 - 0.00021 20.7 0.0 0.0003 20.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.4 001003596.1_16123001_1 - 0.0012 18.2 0.0 0.0021 17.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.4 001003596.1_16123001_1 - 0.11 12.9 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 DAP3 PF10236.7 001098737.1_16124001_2 - 6.7e-96 321.0 0.0 9.4e-96 320.5 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 NTF2 PF02136.18 213374.1_16125001_1 - 2.5e-32 111.8 0.1 4.3e-32 111.0 0.1 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.20 213374.1_16125001_1 - 1e-12 47.5 0.0 1.8e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 213374.1_16125001_1 - 3.2e-05 23.8 0.0 0.00011 22.1 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif HLH PF00010.24 205669.1_16125001_2 - 9.3e-17 60.6 0.2 9.3e-17 60.6 0.2 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain WW PF00397.24 001110470.1_16129001_2 - 3.8e-21 74.6 1.9 3.3e-12 46.0 0.4 2.6 2 0 0 2 2 2 2 WW domain DUF1247 PF06851.9 001111176.1_16125001_1 - 0.76 9.6 8.1 19 5.1 0.0 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1247) C2 PF00168.28 001111176.1_16125001_2 - 0.011 15.9 15.8 10 6.3 0.1 6.4 5 1 1 7 7 7 0 C2 domain WD40 PF00400.30 001007402.1_16127001_3 - 2.2e-55 183.3 46.5 7.3e-08 32.8 0.5 12.3 13 0 0 13 13 11 9 WD domain, G-beta repeat Utp13 PF08625.9 001007402.1_16127001_3 - 8.8e-39 132.5 5.7 1.6e-38 131.6 5.7 1.5 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.5 001007402.1_16127001_3 - 2.8e-19 69.1 9.9 0.03 14.5 0.0 8.3 4 2 4 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 001007402.1_16127001_3 - 1.7e-05 23.5 12.6 0.57 8.6 0.0 6.7 5 2 2 7 7 7 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.3 001007402.1_16127001_3 - 0.00043 19.2 9.6 0.49 9.2 0.2 5.8 3 2 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.9 001007402.1_16127001_3 - 0.0035 16.0 5.1 2.3 6.7 0.1 5.2 1 1 4 5 5 5 1 Nup133 N terminal like Nbas_N PF15492.4 001007402.1_16127001_3 - 0.015 14.5 4.3 5.4 6.1 0.0 4.5 3 2 2 5 5 5 0 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.3 001007402.1_16127001_3 - 0.02 14.1 0.6 10 5.2 0.3 3.6 4 2 1 5 5 5 0 WD40-like domain Cytochrom_D1 PF02239.14 001007402.1_16127001_3 - 0.062 11.7 0.0 0.23 9.8 0.0 2.0 2 0 0 2 2 2 0 Cytochrome D1 heme domain Pox_TAP PF03355.12 001007402.1_16127001_3 - 0.11 11.9 1.1 0.27 10.6 0.1 2.1 2 0 0 2 2 2 0 Viral Trans-Activator Protein PTPRCAP PF15713.3 001007402.1_16127001_3 - 9.5 6.4 13.4 0.22 11.7 4.3 2.7 3 0 0 3 3 3 0 Protein tyrosine phosphatase receptor type C-associated Lectin_C PF00059.19 001328076.1_16123001_1 - 5.5e-20 72.0 0.5 7.9e-20 71.5 0.5 1.2 1 0 0 1 1 1 1 Lectin C-type domain C2 PF00168.28 001100009.2_16122001_1 - 4.6e-16 58.9 0.0 8e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 C2 domain F-box_4 PF15966.3 001113657.1_16125001_1 - 6.4e-48 161.3 0.8 6.4e-48 161.3 0.8 2.0 2 0 0 2 2 2 1 F-box zf-TRAF_2 PF15965.3 001113657.1_16125001_1 - 1.4e-38 131.1 19.5 1.4e-38 131.1 19.5 3.0 3 0 0 3 3 3 1 TRAF-like zinc-finger F-box-like PF12937.5 001113657.1_16125001_1 - 0.0014 18.3 0.2 0.0033 17.2 0.2 1.6 1 0 0 1 1 1 1 F-box-like Rsm1 PF08600.8 001113657.1_16125001_1 - 0.14 12.1 6.0 0.2 11.7 0.3 3.1 3 0 0 3 3 3 0 Rsm1-like fn3 PF00041.19 001079985.3_16129001_2 - 3.4e-11 43.2 0.7 3.9e-06 27.0 0.1 2.8 2 0 0 2 2 2 2 Fibronectin type III domain SPRY PF00622.26 001079985.3_16129001_2 - 7.9e-06 25.9 0.0 2e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 SPRY domain DUF2089 PF09862.7 001079985.3_16129001_2 - 0.43 10.5 5.4 0.37 10.7 2.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2089) Aldo_ket_red PF00248.19 001017779.2_16124001_2 - 1.1e-53 182.2 0.0 5.6e-52 176.6 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family CHCH PF06747.11 200784.1_16122001_1 - 4.1e-06 26.7 3.0 6.3e-06 26.1 3.0 1.3 1 0 0 1 1 1 1 CHCH domain DUF2076 PF09849.7 200784.1_16122001_1 - 0.00032 20.7 6.9 0.00042 20.3 6.9 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) FAM177 PF14774.4 001105707.1_16124001_1 - 1.1e-48 164.3 1.6 1.1e-48 164.3 1.6 1.5 2 0 0 2 2 2 1 FAM177 family AAR2 PF05282.9 001105707.1_16124001_1 - 0.2 10.9 4.8 0.27 10.4 4.8 1.1 1 0 0 1 1 1 0 AAR2 protein ZapB PF06005.10 001105707.1_16124001_1 - 3.1 8.2 11.9 0.078 13.3 5.3 1.7 2 0 0 2 2 2 0 Cell division protein ZapB DUF4561 PF15120.4 001045430.1_16123001_3 - 7.3e-74 246.9 0.6 9.4e-74 246.6 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4561) Ras PF00071.20 001017784.3_16129001_1 - 6.9e-46 155.7 0.0 1.1e-45 155.0 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001017784.3_16129001_1 - 1e-18 67.5 0.0 1.6e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001017784.3_16129001_1 - 0.013 14.8 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family NTP_transferase PF00483.21 001002196.1_16124001_3 - 5.4e-30 104.6 0.0 7.9e-30 104.1 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.5 001002196.1_16124001_3 - 1.6e-07 31.7 0.0 2.5e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.22 001002196.1_16124001_3 - 3.8e-07 29.4 1.5 3.8e-07 29.4 1.5 3.4 3 1 0 3 3 3 1 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.3 001002196.1_16124001_3 - 0.0039 15.3 0.2 0.0055 14.8 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Cwf_Cwc_15 PF04889.10 001002050.2_16123001_3 - 1.9e-77 260.2 21.8 2.3e-77 260.0 21.8 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein NRN1 PF15056.4 001002050.2_16123001_3 - 0.017 15.1 0.4 0.034 14.1 0.4 1.4 1 0 0 1 1 1 0 Neuritin protein family GET2 PF08690.8 001002050.2_16123001_3 - 2.2 7.8 10.6 2.9 7.4 10.6 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 CPSF100_C PF13299.4 001002050.2_16123001_3 - 6.2 6.8 12.1 6.2 6.8 5.6 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF4228 PF14009.4 001002050.2_16123001_3 - 8.2 6.7 9.7 8.2 6.7 2.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) MDFI PF15316.4 001328013.1_16123001_1 - 1.6e-67 227.2 37.4 1.6e-67 227.2 37.4 1.6 2 0 0 2 2 2 1 MyoD family inhibitor TPD52 PF04201.13 199582.2_16125001_2 - 1.8e-61 206.4 8.6 4.2e-31 107.6 1.1 2.2 1 1 1 2 2 2 2 Tumour protein D52 family Filament PF00038.19 001123280.1_16126001_2 - 6.5e-104 347.7 42.2 6.5e-104 347.7 42.2 2.8 3 0 0 3 3 3 1 Intermediate filament protein DUF1664 PF07889.10 001123280.1_16126001_2 - 0.0014 18.5 0.7 0.0014 18.5 0.7 5.2 2 1 3 6 6 6 2 Protein of unknown function (DUF1664) Spidroin_N PF16763.3 001123280.1_16126001_2 - 0.035 14.0 0.7 0.28 11.1 0.1 2.7 2 0 0 2 2 2 0 Major ampullate spidroin 1, spider silk protein 1, N-term Reo_sigmaC PF04582.10 001123280.1_16126001_2 - 0.22 10.7 10.4 0.043 13.1 0.5 2.6 2 1 0 3 3 3 0 Reovirus sigma C capsid protein Baculo_PEP_C PF04513.10 001123280.1_16126001_2 - 0.4 10.6 11.3 7.3 6.5 0.1 3.5 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus MARVEL PF01284.21 001320463.1_16128001_3 - 1.2e-20 73.9 13.7 2.5e-20 72.8 13.7 1.6 1 0 0 1 1 1 1 Membrane-associating domain zf-C2H2 PF00096.24 001077733.1_16129001_2 - 4.1e-23 80.4 50.7 0.00016 21.8 2.8 6.8 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001077733.1_16129001_2 - 1.1e-20 72.9 48.5 5.7e-06 26.4 1.3 7.6 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 001077733.1_16129001_2 - 5.3e-15 54.7 45.8 0.0061 17.2 2.0 7.0 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001077733.1_16129001_2 - 0.094 12.6 41.7 0.048 13.5 3.3 6.5 6 0 0 6 6 6 0 C2H2-type zinc finger zf-Di19 PF05605.10 001077733.1_16129001_2 - 0.57 10.4 29.2 0.13 12.5 4.8 3.8 2 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 001077733.1_16129001_2 - 2.8 8.3 48.2 0.33 11.3 1.3 6.1 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 001077733.1_16129001_2 - 3.5 7.3 23.1 0.09 12.4 1.5 4.7 5 0 0 5 5 5 0 zinc-finger C2H2-type Amidinotransf PF02274.15 213276.1_16127001_3 - 8.9e-15 54.5 0.0 1.3e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Amidinotransferase DOR PF14839.4 001080036.1_16124001_1 - 1.3e-61 208.6 4.5 5.3e-60 203.3 4.5 2.1 1 1 0 1 1 1 1 DOR family SR-25 PF10500.7 199916.1_16123001_1 - 0.00064 19.3 25.8 0.00064 19.3 25.8 2.4 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Med19 PF10278.7 199916.1_16123001_1 - 0.34 10.7 20.2 0.45 10.3 20.2 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF4604 PF15377.4 199916.1_16123001_1 - 0.37 11.1 17.3 0.55 10.5 17.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) STAG PF08514.9 199916.1_16123001_1 - 2.4 8.0 15.1 6.5 6.6 7.4 2.5 2 0 0 2 2 2 0 STAG domain AP3D1 PF06375.9 199916.1_16123001_1 - 3 8.0 21.7 4.3 7.5 21.7 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 OAD_gamma PF04277.11 199916.1_16123001_1 - 8.9 6.8 10.8 19 5.8 10.8 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF3899 PF13038.4 199916.1_16123001_1 - 9.6 6.7 7.7 15 6.1 7.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) DUF4604 PF15377.4 199916.1_16123001_2 - 0.027 14.8 13.9 0.049 14.0 13.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Peptidase_S49_N PF08496.8 199916.1_16123001_2 - 0.15 12.1 9.1 0.2 11.6 9.1 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Metallophos PF00149.26 199916.1_16123001_3 - 7.3e-26 91.8 0.0 1e-25 91.3 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 199916.1_16123001_3 - 1.1e-20 73.6 0.6 4e-20 71.8 0.6 2.0 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain RhoGAP PF00620.25 001030095.1_16128001_1 - 4.3e-46 156.4 0.0 4.3e-46 156.4 0.0 2.9 2 1 1 3 3 3 1 RhoGAP domain FCH PF00611.21 001030095.1_16128001_1 - 1.1e-17 64.0 4.8 3.1e-17 62.5 4.8 1.9 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.26 001030095.1_16128001_1 - 4.9e-11 41.9 0.0 8.7e-11 41.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001030095.1_16128001_1 - 2.6e-10 39.7 0.0 5.3e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 001030095.1_16128001_1 - 3.3e-09 36.3 0.0 6.6e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain GIT_CC PF16559.3 001030095.1_16128001_1 - 2 8.4 7.3 0.19 11.7 1.6 2.3 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor FlaC_arch PF05377.9 001030095.1_16128001_1 - 4.9 7.5 6.3 1.2 9.4 1.3 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Pentaxin PF00354.15 001044314.1_16126001_3 - 2e-27 96.0 0.0 3.4e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.4 001044314.1_16126001_3 - 1.2e-09 38.4 0.0 2.1e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily ABC_tran_CTD PF16326.3 001044314.1_16126001_3 - 0.087 12.9 16.5 0.22 11.7 3.5 3.4 3 0 0 3 3 3 0 ABC transporter C-terminal domain DUF5082 PF16888.3 001044314.1_16126001_3 - 0.09 13.0 6.5 2.1 8.6 0.1 2.7 2 2 0 2 2 2 0 Domain of unknown function (DUF5082) Pox_A_type_inc PF04508.10 001044314.1_16126001_3 - 0.33 10.8 0.1 0.33 10.8 0.1 4.1 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat CLZ PF16526.3 001044314.1_16126001_3 - 0.73 10.1 9.5 3.1 8.1 1.1 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Osmo_CC PF08946.8 001044314.1_16126001_3 - 0.8 9.9 3.7 1.3 9.2 2.2 2.1 1 1 1 2 2 2 0 Osmosensory transporter coiled coil CCDC-167 PF15188.4 001044314.1_16126001_3 - 1.3 9.3 8.6 0.14 12.4 2.1 2.5 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 167 SlyX PF04102.10 001044314.1_16126001_3 - 3.4 8.2 17.7 0.27 11.7 1.4 3.6 2 1 2 4 4 4 0 SlyX ACCA PF03255.12 001044314.1_16126001_3 - 5 6.9 6.8 0.33 10.7 0.6 2.0 3 0 0 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit BST2 PF16716.3 001044314.1_16126001_3 - 6.8 7.2 15.3 14 6.2 1.9 3.5 3 1 0 3 3 3 0 Bone marrow stromal antigen 2 MOZ_SAS PF01853.16 001002365.1_16124001_3 - 4.6e-85 283.6 0.7 7.3e-85 283.0 0.7 1.3 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.6 001002365.1_16124001_3 - 1e-18 66.9 0.1 2.4e-18 65.6 0.1 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.5 001002365.1_16124001_3 - 0.0013 19.0 0.0 0.0027 18.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.23 001002365.1_16124001_3 - 0.0035 17.4 0.0 0.0074 16.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Pkinase PF00069.23 001347831.1_16129001_3 - 2.3e-49 168.0 0.0 3.1e-49 167.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001347831.1_16129001_3 - 2.1e-21 76.2 0.0 3.1e-21 75.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase zf-DBF PF07535.10 001135135.1_16126001_1 - 8.2e-15 54.5 0.4 2.5e-14 52.9 0.4 1.9 1 0 0 1 1 1 1 DBF zinc finger BRCT PF00533.24 001135135.1_16126001_1 - 0.00028 21.1 0.0 0.00028 21.1 0.0 2.2 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain MgtE PF01769.14 001135135.1_16126001_2 - 1.8 8.8 7.4 3.5 7.9 7.4 1.4 1 0 0 1 1 1 0 Divalent cation transporter Nop PF01798.16 001309383.1_16124001_1 - 5e-65 219.1 0.0 5e-65 219.1 0.0 2.0 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.11 001309383.1_16124001_3 - 8.6e-20 70.7 0.5 1.5e-19 69.9 0.5 1.4 1 0 0 1 1 1 1 NOP5NT (NUC127) domain cNMP_binding PF00027.27 001114896.1_16125001_1 - 4.4e-23 81.0 0.0 6.6e-16 58.0 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain DEP PF00610.19 001114896.1_16125001_1 - 7.2e-21 73.9 0.9 2e-20 72.5 0.9 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF2012 PF09430.8 001128763.1_16122001_3 - 1.3e-32 112.3 0.0 2e-32 111.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.4 001128763.1_16122001_3 - 0.00036 20.6 0.0 0.0006 19.9 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.4 001128763.1_16122001_3 - 0.0091 15.8 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 CarboxypepD_reg-like domain LIM PF00412.20 001003732.1_16124001_3 - 7.4e-45 150.9 72.2 5.2e-13 48.9 9.7 5.4 5 0 0 5 5 5 5 LIM domain zf-ribbon_3 PF13248.4 001003732.1_16124001_3 - 0.075 12.3 0.2 0.075 12.3 0.2 6.6 10 0 0 10 10 10 0 zinc-ribbon domain TAFII28 PF04719.12 001002548.1_16122001_2 - 9.3e-40 134.6 0.0 1.6e-39 133.8 0.0 1.4 1 0 0 1 1 1 1 hTAFII28-like protein conserved region CBFD_NFYB_HMF PF00808.21 001002548.1_16122001_2 - 4.2e-06 26.8 0.2 9.7e-06 25.6 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone NAD_kinase PF01513.19 001017580.1_16124001_2 - 1.1e-65 221.5 0.0 1.4e-65 221.2 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.22 001017580.1_16124001_2 - 0.12 11.9 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain C2 PF00168.28 001326322.1_16125001_3 - 6.6e-21 74.4 0.1 6.6e-11 42.3 0.0 2.3 2 0 0 2 2 2 2 C2 domain AMMECR1 PF01871.15 200581.1_16123001_1 - 1.2e-49 168.0 0.0 1.5e-49 167.6 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 HLH PF00010.24 201339.3_16124001_2 - 2e-15 56.3 0.3 2e-15 56.3 0.3 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain SMC_N PF02463.17 214689.1_16129001_2 - 1.1e-58 198.1 38.4 2.6e-58 196.9 38.4 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.11 214689.1_16129001_2 - 4.9e-20 71.8 0.0 1.4e-19 70.4 0.0 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.4 214689.1_16129001_2 - 6.8e-18 65.8 4.8 6.8e-18 65.8 4.8 7.8 2 2 5 7 7 7 1 AAA domain AAA_15 PF13175.4 214689.1_16129001_2 - 7.6e-12 45.4 16.7 7.6e-12 45.4 16.7 4.3 2 2 2 4 4 4 2 AAA ATPase domain AAA_21 PF13304.4 214689.1_16129001_2 - 3.5e-10 40.1 16.6 3.8e-06 26.8 0.0 4.8 4 2 1 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 214689.1_16129001_2 - 0.0037 16.8 0.0 0.0081 15.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Reo_sigmaC PF04582.10 214689.1_16129001_2 - 0.47 9.7 23.3 2.1 7.5 4.7 4.2 3 1 0 4 4 4 0 Reovirus sigma C capsid protein ABC_tran PF00005.25 214689.1_16129001_2 - 1.1 9.6 0.0 1.1 9.6 0.0 6.8 2 2 1 3 3 3 0 ABC transporter Baculo_PEP_C PF04513.10 214689.1_16129001_2 - 3.2 7.7 32.2 0.085 12.8 0.4 6.0 4 2 2 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus Mitoc_L55 PF09776.7 001111179.1_16122001_2 - 1.3e-43 147.2 1.2 1.8e-43 146.9 1.2 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L55 T2SSK PF03934.11 001111179.1_16122001_2 - 0.14 11.4 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein K IQ PF00612.25 001166122.3_16122001_3 - 0.053 13.2 0.3 0.098 12.4 0.3 1.4 1 0 0 1 1 1 0 IQ calmodulin-binding motif FA_desaturase PF00487.22 212700.1_16124001_3 - 4.9e-25 88.7 14.7 8.6e-25 87.9 14.7 1.5 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.8 212700.1_16124001_3 - 3.9e-22 77.3 0.4 8.4e-22 76.2 0.4 1.6 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) NUDIX PF00293.26 001004648.1_16124001_3 - 5.9e-19 68.3 0.4 9e-19 67.7 0.4 1.2 1 0 0 1 1 1 1 NUDIX domain Thioredoxin PF00085.18 001113576.1_16125001_1 - 1e-70 234.1 1.0 3.5e-23 81.4 0.0 3.8 4 0 0 4 4 4 3 Thioredoxin Thioredoxin_2 PF13098.4 001113576.1_16125001_1 - 1.1e-20 73.9 2.6 1.2e-05 25.6 0.1 3.9 3 1 0 3 3 3 3 Thioredoxin-like domain Thioredoxin_7 PF13899.4 001113576.1_16125001_1 - 4.7e-13 49.0 0.1 0.002 18.1 0.0 3.5 3 0 0 3 3 3 3 Thioredoxin-like AhpC-TSA PF00578.19 001113576.1_16125001_1 - 1.3e-12 47.6 0.4 0.00011 21.9 0.1 3.5 3 0 0 3 3 3 3 AhpC/TSA family Thioredoxin_8 PF13905.4 001113576.1_16125001_1 - 1.4e-10 41.2 0.2 0.0076 16.4 0.1 4.0 3 1 0 3 3 3 3 Thioredoxin-like TraF PF13728.4 001113576.1_16125001_1 - 1.6e-10 41.1 0.2 0.0091 15.7 0.0 3.6 3 1 0 3 3 3 3 F plasmid transfer operon protein Redoxin PF08534.8 001113576.1_16125001_1 - 1.8e-08 34.1 0.2 0.016 14.7 0.0 3.3 3 0 0 3 3 3 2 Redoxin OST3_OST6 PF04756.11 001113576.1_16125001_1 - 4.2e-08 32.7 0.3 0.004 16.4 0.0 3.2 2 1 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_6 PF13848.4 001113576.1_16125001_1 - 5e-08 33.0 3.1 0.00041 20.2 0.0 4.4 5 0 0 5 5 5 1 Thioredoxin-like domain Thioredoxin_9 PF14595.4 001113576.1_16125001_1 - 3.7e-07 29.8 0.0 0.11 12.2 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin Glutaredoxin PF00462.22 001113576.1_16125001_1 - 0.0011 19.0 5.3 1.1 9.3 0.1 3.9 3 0 0 3 3 3 1 Glutaredoxin HyaE PF07449.9 001113576.1_16125001_1 - 0.016 15.1 0.0 15 5.5 0.0 3.4 3 0 0 3 3 3 0 Hydrogenase-1 expression protein HyaE SepSecS PF05889.11 200154.1_16124001_3 - 6.6e-164 545.1 0.0 7.8e-164 544.8 0.0 1.0 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.19 200154.1_16124001_3 - 8.9e-05 21.8 0.0 0.00013 21.2 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase zf-H2C2_2 PF13465.4 001114471.1_16123001_2 - 2.7e-92 299.3 89.3 3.4e-10 39.7 2.0 12.4 12 0 0 12 12 12 12 Zinc-finger double domain zf-C2H2 PF00096.24 001114471.1_16123001_2 - 2.8e-68 222.6 107.4 2.5e-07 30.7 1.2 13.0 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001114471.1_16123001_2 - 8e-46 150.6 96.5 0.00022 21.6 0.7 12.7 13 0 0 13 13 12 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001114471.1_16123001_2 - 7.7e-25 86.2 77.3 0.001 18.9 0.4 12.7 12 1 0 12 12 12 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001114471.1_16123001_2 - 2.5e-19 68.9 37.9 0.013 15.7 0.2 12.1 12 0 0 12 12 12 4 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 001114471.1_16123001_2 - 1e-15 57.0 76.9 0.0055 16.3 1.2 12.2 12 0 0 12 12 12 8 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 001114471.1_16123001_2 - 2.2e-14 53.2 42.6 0.057 13.4 0.3 9.3 4 3 8 12 12 12 10 Zinc ribbon domain zf-C2HE PF16278.3 001114471.1_16123001_2 - 8.7e-14 51.6 78.9 0.013 15.9 1.2 12.1 1 1 11 12 12 12 7 C2HE / C2H2 / C2HC zinc-binding finger zf-C2HC_2 PF13913.4 001114471.1_16123001_2 - 8.7e-13 47.7 50.1 0.13 12.1 0.1 12.1 12 0 0 12 12 12 5 zinc-finger of a C2HC-type DZR PF12773.5 001114471.1_16123001_2 - 1.3e-11 44.2 36.1 0.098 12.6 5.1 6.5 3 1 1 4 4 4 3 Double zinc ribbon zf-LYAR PF08790.9 001114471.1_16123001_2 - 8.1e-11 41.5 62.6 0.1 12.4 0.7 12.1 12 0 0 12 12 12 7 LYAR-type C2HC zinc finger ADK_lid PF05191.12 001114471.1_16123001_2 - 1.9e-07 30.9 27.7 0.48 10.4 1.7 8.6 5 4 3 8 8 8 2 Adenylate kinase, active site lid XPA_N PF01286.16 001114471.1_16123001_2 - 2.2e-07 30.7 37.9 3.9 7.5 0.0 11.7 12 0 0 12 12 12 1 XPA protein N-terminal C1_1 PF00130.20 001114471.1_16123001_2 - 1e-06 28.3 55.3 0.039 13.7 0.9 10.0 2 2 9 11 11 11 4 Phorbol esters/diacylglycerol binding domain (C1 domain) HypA PF01155.17 001114471.1_16123001_2 - 1.3e-06 28.2 34.5 0.35 10.8 0.2 7.0 1 1 9 10 10 10 7 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-met PF12874.5 001114471.1_16123001_2 - 9.5e-06 25.7 90.9 0.058 13.7 0.9 12.5 13 0 0 13 13 12 5 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.3 001114471.1_16123001_2 - 2.5e-05 24.8 42.7 0.51 11.0 1.2 7.4 2 1 6 8 8 8 5 zinc-ribbon family zf-C2H2_2 PF12756.5 001114471.1_16123001_2 - 5.9e-05 23.2 60.1 2.1 8.6 0.6 11.3 1 1 11 12 12 12 3 C2H2 type zinc-finger (2 copies) zf-AN1 PF01428.14 001114471.1_16123001_2 - 6.3e-05 22.9 47.5 8.1 6.6 0.1 11.9 12 0 0 12 12 12 0 AN1-like Zinc finger zf-trcl PF13451.4 001114471.1_16123001_2 - 0.00076 19.2 49.1 0.77 9.6 0.1 11.7 11 1 0 11 11 11 2 Probable zinc-ribbon domain zinc_ribbon_9 PF14369.4 001114471.1_16123001_2 - 0.0013 18.9 29.5 19 5.4 0.1 10.4 12 0 0 12 12 12 0 zinc-ribbon zf-H2C2_5 PF13909.4 001114471.1_16123001_2 - 0.01 15.5 1.3 0.01 15.5 1.3 15.2 14 3 0 14 14 13 0 C2H2-type zinc-finger domain DUF3268 PF11672.6 001114471.1_16123001_2 - 0.017 15.3 29.4 2.6 8.3 1.1 6.4 2 1 1 6 6 6 0 zinc-finger-containing domain zf-RING_7 PF02591.13 001114471.1_16123001_2 - 0.026 14.6 33.8 4.1 7.5 0.1 10.1 11 0 0 11 11 11 0 C4-type zinc ribbon domain zf-FCS PF06467.12 001114471.1_16123001_2 - 0.11 12.3 55.2 3.7 7.5 0.4 11.0 9 3 2 11 11 10 0 MYM-type Zinc finger with FCS sequence motif GAGA PF09237.9 001114471.1_16123001_2 - 0.12 12.1 18.4 0.98 9.1 0.0 6.9 3 2 6 9 9 9 0 GAGA factor PyrI_C PF02748.13 001114471.1_16123001_2 - 0.57 10.0 30.5 13 5.6 0.2 9.2 10 1 1 11 11 11 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain YhfH PF14149.4 001114471.1_16123001_2 - 0.71 9.8 45.5 11 5.9 0.1 10.8 12 0 0 12 12 11 0 YhfH-like protein zf-Sec23_Sec24 PF04810.13 001114471.1_16123001_2 - 2.5 8.1 39.9 0.55 10.2 0.2 9.6 7 2 5 12 12 11 0 Sec23/Sec24 zinc finger FYDLN_acid PF09538.8 001114471.1_16123001_2 - 9.3 6.9 29.2 55 4.4 0.9 9.2 2 2 7 9 9 9 0 Protein of unknown function (FYDLN_acid) DUF2256 PF10013.7 001114471.1_16123001_2 - 10 6.2 43.5 24 5.0 0.0 11.7 12 0 0 12 12 12 0 Uncharacterized protein conserved in bacteria (DUF2256) Pkinase PF00069.23 201029.1_16126001_3 - 1.8e-62 210.9 0.0 1.8e-62 210.9 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 201029.1_16126001_3 - 5.5e-37 127.3 0.0 1.1e-36 126.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 201029.1_16126001_3 - 4e-32 109.7 30.0 4.8e-16 58.2 6.4 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C2 PF00168.28 201029.1_16126001_3 - 3.7e-27 94.5 0.1 7.8e-27 93.4 0.1 1.6 1 0 0 1 1 1 1 C2 domain Pkinase_C PF00433.22 201029.1_16126001_3 - 2.1e-05 25.0 0.1 4.7e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.21 201029.1_16126001_3 - 0.17 11.6 0.0 0.36 10.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family C1_2 PF03107.14 201029.1_16126001_3 - 0.49 10.6 21.6 0.3 11.3 7.8 2.7 2 0 0 2 2 2 0 C1 domain LRR_8 PF13855.4 001145582.2_16126001_3 - 3.5e-61 202.7 69.4 3.6e-12 45.7 6.1 6.4 1 1 7 8 8 8 8 Leucine rich repeat LRR_4 PF12799.5 001145582.2_16126001_3 - 3.9e-20 71.4 27.7 0.00073 19.7 1.2 7.3 5 1 3 8 8 8 7 Leucine Rich repeats (2 copies) I-set PF07679.14 001145582.2_16126001_3 - 3.6e-15 55.7 0.0 6.7e-15 54.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001145582.2_16126001_3 - 1.1e-12 48.2 0.0 4.5e-12 46.3 0.0 2.2 1 0 0 1 1 1 1 Immunoglobulin domain LRR_5 PF13306.4 001145582.2_16126001_3 - 9.2e-12 44.9 0.0 9.3e-06 25.5 0.0 3.2 2 1 1 3 3 3 3 Leucine rich repeats (6 copies) ig PF00047.23 001145582.2_16126001_3 - 1.3e-10 41.1 0.0 3.6e-10 39.8 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.31 001145582.2_16126001_3 - 6.3e-09 34.9 24.5 0.4 11.2 0.3 11.0 12 0 0 12 12 12 1 Leucine Rich Repeat Ig_2 PF13895.4 001145582.2_16126001_3 - 1.3e-07 31.7 0.1 2.4e-06 27.7 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain LRRNT PF01462.16 001145582.2_16126001_3 - 0.00029 20.3 5.2 0.00029 20.3 5.2 2.9 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 001145582.2_16126001_3 - 0.0027 17.1 9.5 0.11 11.8 2.2 3.1 2 1 1 3 3 3 2 Leucine-rich repeat V-set PF07686.15 001145582.2_16126001_3 - 0.0033 17.4 0.0 0.016 15.2 0.0 2.2 1 1 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.10 001145582.2_16126001_3 - 0.033 14.1 0.0 0.081 12.9 0.0 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain LRRCT PF01463.22 001145582.2_16126001_3 - 0.71 10.4 7.2 0.36 11.3 0.2 4.2 4 0 0 4 4 4 0 Leucine rich repeat C-terminal domain Tropomodulin PF03250.12 001004616.2_16123001_3 - 2.9e-15 56.4 3.0 6.1e-15 55.4 1.3 2.1 1 1 0 2 2 2 1 Tropomodulin TEX19 PF15553.4 001004616.2_16123001_3 - 0.23 11.3 1.8 6 6.7 0.1 2.2 2 0 0 2 2 2 0 Testis-expressed protein 19 LRR_6 PF13516.4 001004616.2_16123001_3 - 0.72 9.9 0.1 0.72 9.9 0.1 3.8 4 0 0 4 4 4 0 Leucine Rich repeat SCAMP PF04144.11 205692.1_16125001_2 - 3.7e-72 242.1 16.0 6.5e-72 241.3 16.0 1.4 1 0 0 1 1 1 1 SCAMP family Lipocalin_2 PF08212.10 001201349.1_16123001_3 - 4.8e-22 78.3 0.0 9.5e-22 77.4 0.0 1.5 2 0 0 2 2 2 1 Lipocalin-like domain Lipocalin PF00061.21 001201349.1_16123001_3 - 6.7e-17 61.9 0.0 9.8e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Triabin PF03973.11 001201349.1_16123001_3 - 0.015 15.0 0.2 0.029 14.1 0.2 1.7 1 1 0 1 1 1 0 Triabin SWIRM-assoc_1 PF16495.3 001201349.1_16123001_3 - 0.036 14.0 0.1 0.061 13.3 0.1 1.2 1 0 0 1 1 1 0 SWIRM-associated region 1 DUF4745 PF15923.3 001201349.1_16123001_3 - 0.054 13.3 1.1 5.5 6.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4745) HMA PF00403.24 001008609.1_16124001_1 - 0.01 16.2 0.1 0.02 15.2 0.1 1.5 1 0 0 1 1 1 0 Heavy-metal-associated domain Arm PF00514.21 001008609.1_16124001_1 - 0.056 13.4 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat C2 PF00168.28 001039973.2_16127001_3 - 0.00065 19.8 0.0 0.0016 18.6 0.0 1.6 1 0 0 1 1 1 1 C2 domain NHR2 PF08788.9 001039973.2_16127001_3 - 0.1 12.2 1.8 3.4 7.4 0.2 3.0 3 0 0 3 3 3 0 NHR2 domain like Pkinase PF00069.23 200829.1_16125001_2 - 3.3e-78 262.6 0.0 5.4e-78 261.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 200829.1_16125001_2 - 1.3e-35 122.9 0.0 1.8e-35 122.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 200829.1_16125001_2 - 1.9e-09 37.1 0.0 1.6e-08 34.1 0.0 2.1 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.20 200829.1_16125001_2 - 0.0011 18.4 0.5 0.0011 18.4 0.5 1.7 2 0 0 2 2 2 1 RIO1 family APH PF01636.21 200829.1_16125001_2 - 0.002 17.9 0.0 0.96 9.2 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.12 200829.1_16125001_2 - 0.0045 16.2 0.3 0.0086 15.3 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 200829.1_16125001_2 - 0.037 13.5 3.0 2.1 7.8 0.0 2.6 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 zf-TRAF_2 PF15965.3 001037564.1_16124001_1 - 0.12 12.7 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 TRAF-like zinc-finger Complex1_51K PF01512.15 001037564.1_16124001_3 - 1.4e-50 171.0 0.0 2.3e-50 170.3 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.7 001037564.1_16124001_3 - 6.1e-30 103.0 0.0 1.1e-29 102.2 0.0 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.7 001037564.1_16124001_3 - 1.5e-05 24.6 0.0 3.1e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 SLBB domain DUF4748 PF15932.3 137168.1_16123120_2 - 2e-15 56.1 0.0 4.5e-15 55.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4748) Cytomega_UL84 PF06284.9 137168.1_16123120_3 - 0.13 10.6 1.4 0.17 10.1 1.4 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Ribosomal_60s PF00428.17 137168.1_16123120_3 - 6.4 7.3 7.9 11 6.6 7.9 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein DnaJ PF00226.29 136944.1_16123120_2 - 4.6e-19 68.2 1.1 4.6e-19 68.2 1.1 1.6 2 0 0 2 2 2 1 DnaJ domain Coiled-coil_56 PF09813.7 136944.1_16123120_2 - 0.0038 17.1 0.3 0.0069 16.3 0.3 1.3 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 56 SHOCT PF09851.7 136944.1_16123120_2 - 0.15 11.7 0.1 0.15 11.7 0.1 1.7 2 0 0 2 2 2 0 Short C-terminal domain PI3Ka PF00613.18 137316.1_16126120_1 - 1.5e-57 193.9 0.7 3.2e-57 192.8 0.7 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.22 137316.1_16126120_1 - 5.8e-47 159.0 0.0 1.1e-46 158.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3_PI4_kinase PF00454.25 137316.1_16126120_1 - 1.7e-14 54.1 0.0 3.2e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase HEAT_2 PF13646.4 137316.1_16126120_1 - 0.015 15.6 0.2 0.033 14.4 0.2 1.6 1 0 0 1 1 1 0 HEAT repeats Syntaxin PF00804.23 131945.1_16124120_1 - 2.4e-58 197.0 15.4 3.6e-58 196.4 15.4 1.2 1 0 0 1 1 1 1 Syntaxin Syntaxin_2 PF14523.4 131945.1_16124120_1 - 5.4e-11 42.6 7.7 5.4e-11 42.6 7.7 2.0 2 0 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.17 131945.1_16124120_1 - 1.6e-07 31.0 6.7 3.4e-07 30.0 0.0 3.2 3 0 0 3 3 3 1 SNARE domain MASE2 PF05230.9 131945.1_16124120_1 - 0.065 13.2 0.1 0.15 12.1 0.1 1.6 1 0 0 1 1 1 0 MASE2 domain DUF3540 PF12059.6 131945.1_16124120_1 - 0.067 12.8 4.1 1.5 8.4 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3540) Baculo_PEP_C PF04513.10 131945.1_16124120_1 - 0.14 12.1 3.7 0.23 11.4 2.0 2.0 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Exo5 PF09810.7 131945.1_16124120_1 - 0.61 9.3 5.6 1.1 8.6 5.6 1.3 1 0 0 1 1 1 0 Exonuclease V - a 5' deoxyribonuclease DUF948 PF06103.9 131945.1_16124120_1 - 1 9.5 6.2 14 5.9 0.9 3.3 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) MCPsignal PF00015.19 131945.1_16124120_1 - 2.6 7.6 15.2 3.2 7.3 0.7 2.5 1 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain ERp29 PF07749.10 131945.1_16124120_1 - 2.8 8.7 9.5 6.9 7.5 8.2 2.2 1 1 1 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain DUF1690 PF07956.9 131945.1_16124120_1 - 5.7 7.2 15.3 4.7 7.5 2.0 2.5 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) FlaC_arch PF05377.9 131945.1_16124120_1 - 6.9 7.0 14.2 0.051 13.8 1.4 3.4 3 2 0 3 3 3 0 Flagella accessory protein C (FlaC) CorA PF01544.16 131945.1_16124120_1 - 9.3 5.3 10.8 2.5 7.2 5.4 2.1 1 1 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF1126 PF06565.10 132140.1_16125120_1 - 2.2e-38 130.1 0.2 7.6e-30 102.7 0.0 2.6 2 0 0 2 2 2 2 DUF1126 PH-like domain DUF1126 PF06565.10 132140.1_16125120_3 - 3.3e-61 203.4 0.1 1.8e-31 107.8 0.2 2.2 2 0 0 2 2 2 2 DUF1126 PH-like domain Dynein_attach_N PF15867.3 131952.1_16125120_1 - 7e-27 93.0 0.2 1.1e-26 92.4 0.2 1.3 1 0 0 1 1 1 1 Dynein attachment factor N-terminus RPAP3_C PF13877.4 131952.1_16125120_1 - 3.3e-15 56.3 0.0 5.9e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 V-set PF07686.15 131952.1_16125120_3 - 7.3e-11 42.1 0.0 3.5e-07 30.2 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 131952.1_16125120_3 - 1.2e-08 35.3 0.3 0.0037 17.7 0.0 2.7 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 131952.1_16125120_3 - 2.6e-07 30.6 0.0 0.008 16.2 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 131952.1_16125120_3 - 1.3e-06 28.2 0.0 0.093 12.7 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 131952.1_16125120_3 - 0.00085 19.5 0.1 0.067 13.4 0.0 2.7 2 1 0 2 2 2 1 Immunoglobulin domain NAD_binding_10 PF13460.4 131978.1_16125120_2 - 0.039 13.7 0.0 0.059 13.1 0.0 1.1 1 0 0 1 1 1 0 NAD(P)H-binding BTB_3 PF16017.3 144779.1_16126120_1 - 5.3e-51 171.0 0.0 8.8e-51 170.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.20 144779.1_16126120_1 - 0.0019 18.3 0.0 0.0038 17.4 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain RRM_1 PF00076.20 132113.1_16124120_3 - 2.5e-26 91.2 0.0 3.8e-26 90.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 132113.1_16124120_3 - 0.00015 21.7 0.0 0.00028 20.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif RRM_3 PF08777.9 132113.1_16124120_3 - 0.0013 18.6 0.0 0.0025 17.7 0.0 1.4 1 0 0 1 1 1 1 RNA binding motif RRM_1 PF00076.20 132111.1_16123120_3 - 1.2e-26 92.2 0.0 1.7e-26 91.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 132111.1_16123120_3 - 7.1e-05 22.7 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif RRM_3 PF08777.9 132111.1_16123120_3 - 0.00069 19.5 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 RNA binding motif Dpy-30 PF05186.11 130111.1_16122120_1 - 5.7e-14 51.4 0.3 2.9e-07 29.9 0.0 2.4 2 0 0 2 2 2 2 Dpy-30 motif RRM_1 PF00076.20 132109.1_16122120_3 - 1.1e-26 92.2 0.0 1.7e-26 91.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 132109.1_16122120_3 - 6.8e-05 22.8 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif RRM_3 PF08777.9 132109.1_16122120_3 - 0.00068 19.5 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 RNA binding motif Aldo_ket_red PF00248.19 137311.1_16124120_1 - 4.5e-17 62.0 0.0 6.8e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.19 137311.1_16124120_2 - 9.3e-48 162.7 0.0 1.3e-47 162.3 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF525 PF04379.12 144396.1_16126120_1 - 3.7e-16 59.0 0.0 2.5e-15 56.4 0.0 2.4 3 0 0 3 3 3 1 ApaG domain SMI1_KNR4 PF09346.8 144396.1_16126120_1 - 1e-11 45.2 0.0 1.6e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) F-box-like PF12937.5 144396.1_16126120_1 - 9.4e-10 38.1 2.5 1.6e-09 37.3 0.9 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 144396.1_16126120_1 - 1.2e-08 34.5 4.3 2.8e-08 33.3 4.3 1.7 1 0 0 1 1 1 1 F-box domain SUKH_6 PF14568.4 144396.1_16126120_1 - 0.0015 18.8 0.0 0.0026 18.1 0.0 1.4 1 0 0 1 1 1 1 SMI1-KNR4 cell-wall SUKH_5 PF14567.4 144396.1_16126120_1 - 0.058 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall DUF525 PF04379.12 144396.1_16126120_3 - 1.9e-06 27.9 0.3 3.2e-06 27.1 0.3 1.3 1 0 0 1 1 1 1 ApaG domain WD40 PF00400.30 130148.1_16127120_3 - 9.7e-26 89.4 15.0 1.5e-05 25.5 0.1 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 130148.1_16127120_3 - 4.7e-10 39.5 0.0 0.0055 16.8 0.0 4.8 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain DEP PF00610.19 144689.1_16124120_1 - 4.4e-16 58.6 0.0 9.4e-16 57.5 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.20 144689.1_16124120_1 - 1.5e-11 44.0 0.7 3.1e-11 43.0 0.2 1.9 2 0 0 2 2 2 1 GGL domain RGS PF00615.17 144689.1_16124120_1 - 9.3e-09 35.5 0.1 9.3e-09 35.5 0.1 2.7 4 0 0 4 4 4 1 Regulator of G protein signaling domain RRM_1 PF00076.20 132112.1_16123120_3 - 1.2e-26 92.1 0.0 1.9e-26 91.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 132112.1_16123120_3 - 6.3e-05 22.9 0.0 0.00014 21.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif RRM_3 PF08777.9 132112.1_16123120_3 - 0.00074 19.4 0.0 0.0012 18.7 0.0 1.2 1 0 0 1 1 1 1 RNA binding motif V-set PF07686.15 144433.1_16129120_3 - 8e-17 61.2 0.0 1.4e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 144433.1_16129120_3 - 3.6e-05 23.7 0.0 8.5e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 144433.1_16129120_3 - 0.00015 22.1 0.1 0.00032 21.1 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 144433.1_16129120_3 - 0.013 15.4 0.0 0.028 14.4 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain DUF1191 PF06697.10 144433.1_16129120_3 - 0.13 11.3 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) UQ_con PF00179.24 135206.1_16125120_3 - 1.7e-23 82.7 0.0 2.6e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ATP-synt_F6 PF05511.9 137292.1_16122120_2 - 1.3e-14 54.2 0.0 2e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ATP synthase coupling factor 6 CCDC85 PF10226.7 135163.1_16126120_1 - 1.2e-98 328.4 8.7 1.9e-98 327.7 8.7 1.3 1 0 0 1 1 1 1 CCDC85 family Herpes_capsid PF06112.9 135163.1_16126120_1 - 0.0039 17.2 1.8 0.0057 16.6 0.6 1.9 2 0 0 2 2 2 1 Gammaherpesvirus capsid protein AMH_N PF04709.10 135163.1_16126120_1 - 0.0041 16.0 0.9 0.0041 16.0 0.9 1.4 1 1 0 1 1 1 1 Anti-Mullerian hormone, N terminal region Shugoshin_N PF07558.9 135163.1_16126120_1 - 0.24 11.2 3.1 0.48 10.2 3.1 1.5 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region Mod_r PF07200.11 135163.1_16126120_1 - 4 7.4 9.6 19 5.2 7.7 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF972 PF06156.11 135163.1_16126120_1 - 5.1 7.7 9.0 1.4 9.4 1.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Prenyltrans PF00432.19 003374.1_16122120_2 - 0.047 13.3 0.3 4 7.1 0.0 2.3 2 0 0 2 2 2 0 Prenyltransferase and squalene oxidase repeat Ig_3 PF13927.4 137296.1_16122120_1 - 0.0021 18.5 0.0 0.009 16.5 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 137296.1_16122120_1 - 0.065 13.3 0.0 0.29 11.2 0.0 2.0 1 1 0 1 1 1 0 Immunoglobulin domain SR-25 PF10500.7 134974.1_16122120_1 - 0.32 10.4 5.0 0.42 10.0 5.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Lum_binding PF00677.15 023325.1_16122120_1 - 0.13 12.1 0.5 1.5 8.7 0.2 2.3 2 0 0 2 2 2 0 Lumazine binding domain IKKbetaNEMObind PF12179.6 120315.1_16122120_3 - 0.041 13.8 0.6 0.076 12.9 0.6 1.4 1 0 0 1 1 1 0 I-kappa-kinase-beta NEMO binding domain Thymosin PF01290.18 015622.1_16121120_2 - 3.5e-20 71.3 6.7 1.1e-19 69.7 6.7 1.9 1 0 0 1 1 1 1 Thymosin beta-4 family zf-C2H2 PF00096.24 023328.1_16121120_1 - 2.4e-14 52.8 11.5 0.00017 21.7 0.9 3.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 023328.1_16121120_1 - 2.6e-13 49.4 10.7 0.00016 22.1 0.5 3.4 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.4 023328.1_16121120_1 - 2e-10 40.5 13.6 1.2e-05 25.4 0.1 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_6 PF13912.4 023328.1_16121120_1 - 1.5e-08 34.3 7.4 0.0024 17.6 0.1 3.2 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.5 023328.1_16121120_1 - 7.6e-08 32.4 9.4 0.00082 19.6 0.1 3.3 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 023328.1_16121120_1 - 1.2e-07 31.8 7.5 0.016 15.4 0.1 3.4 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding Rad50_zn_hook PF04423.12 023328.1_16121120_1 - 1.6e-05 24.5 1.3 0.037 13.7 0.0 2.4 2 0 0 2 2 2 2 Rad50 zinc hook motif zf-C2HE PF16278.3 023328.1_16121120_1 - 4.5e-05 23.7 12.6 0.0085 16.4 1.0 3.1 1 1 2 3 3 3 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.3 023328.1_16121120_1 - 0.00027 20.5 3.5 0.46 10.1 0.1 3.1 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-C2H2_2 PF12756.5 023328.1_16121120_1 - 0.00029 21.0 9.0 0.097 12.9 0.6 2.3 1 1 0 2 2 2 2 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.8 023328.1_16121120_1 - 0.0012 18.7 4.7 0.0017 18.3 1.2 2.3 2 0 0 2 2 2 1 Zinc ribbon domain zf-Di19 PF05605.10 023328.1_16121120_1 - 0.0024 18.0 10.5 0.082 13.1 0.9 2.4 1 1 2 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding C1_4 PF07975.10 023328.1_16121120_1 - 0.0025 17.9 7.3 0.027 14.6 2.4 2.5 1 1 1 2 2 2 2 TFIIH C1-like domain zf-C2H2_9 PF16293.3 023328.1_16121120_1 - 0.0031 17.2 4.2 0.023 14.4 0.1 2.6 2 1 1 3 3 3 1 C2H2 type zinc-finger (1 copy) zf-C2H2_8 PF15909.3 023328.1_16121120_1 - 0.007 16.5 5.1 0.019 15.2 1.6 2.1 1 1 1 2 2 2 1 C2H2-type zinc ribbon BolA PF01722.16 023328.1_16121120_1 - 0.0081 16.3 0.8 1.6 8.9 0.1 2.2 2 0 0 2 2 2 1 BolA-like protein Elf1 PF05129.11 023328.1_16121120_1 - 0.0084 16.0 7.3 0.03 14.2 1.6 2.2 1 1 1 2 2 2 1 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.4 023328.1_16121120_1 - 0.0093 15.7 8.3 0.012 15.4 2.6 3.0 2 1 0 2 2 2 1 zinc-ribbon domain CpXC PF14353.4 023328.1_16121120_1 - 0.023 14.6 5.7 0.76 9.7 1.1 2.6 1 1 1 2 2 2 0 CpXC protein Prok-RING_1 PF14446.4 023328.1_16121120_1 - 0.069 13.0 6.1 3 7.7 0.1 3.0 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-Sec23_Sec24 PF04810.13 023328.1_16121120_1 - 0.083 12.8 4.9 0.25 11.3 0.7 2.5 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger ADK_lid PF05191.12 023328.1_16121120_1 - 0.16 11.9 3.3 3.4 7.6 1.4 2.6 2 1 0 2 2 2 0 Adenylate kinase, active site lid zf-BED PF02892.13 023328.1_16121120_1 - 0.19 11.7 5.9 2.3 8.2 0.6 2.4 2 0 0 2 2 2 0 BED zinc finger zf-trcl PF13451.4 023328.1_16121120_1 - 0.2 11.5 6.2 0.18 11.6 1.8 2.3 2 0 0 2 2 2 0 Probable zinc-ribbon domain HypA PF01155.17 023328.1_16121120_1 - 0.27 11.1 6.5 7.2 6.5 6.3 2.1 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.10 023328.1_16121120_1 - 0.34 10.8 8.4 18 5.2 8.4 2.9 1 1 0 1 1 1 0 zinc-ribbons DUF2225 PF09986.7 023328.1_16121120_1 - 0.45 10.1 6.2 0.8 9.3 0.6 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) SprT-like PF10263.7 023328.1_16121120_1 - 0.61 9.8 8.1 0.54 10.0 2.9 2.1 1 1 1 2 2 2 0 SprT-like family zf-FPG_IleRS PF06827.12 023328.1_16121120_1 - 0.63 9.8 5.8 5.7 6.8 0.1 3.0 3 0 0 3 3 2 0 Zinc finger found in FPG and IleRS zinc_ribbon_15 PF17032.3 023328.1_16121120_1 - 0.68 10.6 9.4 0.25 12.0 2.4 2.2 1 1 1 2 2 2 0 zinc-ribbon family C1_2 PF03107.14 023328.1_16121120_1 - 1.2 9.4 15.0 5.9 7.2 0.8 3.3 2 1 1 3 3 2 0 C1 domain RNA_POL_M_15KD PF02150.14 023328.1_16121120_1 - 2 8.2 8.4 3.9 7.3 0.3 3.1 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit zf-RING_5 PF14634.4 023328.1_16121120_1 - 4 7.4 10.3 7.2 6.5 0.4 2.8 1 1 1 2 2 2 0 zinc-RING finger domain UDPGT PF00201.16 033478.1_16124120_1 - 4.9e-45 154.1 0.3 6.2e-45 153.8 0.3 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase UPF0560 PF10577.7 033478.1_16124120_1 - 0.035 12.5 0.6 0.047 12.1 0.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 UDPGT PF00201.16 033478.1_16124120_2 - 4.4e-45 154.3 0.0 1e-35 123.4 0.0 2.0 2 0 0 2 2 2 2 UDP-glucoronosyl and UDP-glucosyl transferase UDPGT PF00201.16 033478.1_16124120_3 - 5.8e-30 104.4 0.3 2.2e-29 102.5 0.1 1.8 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Pro_isomerase PF00160.19 137200.1_16125120_2 - 1.4e-40 139.0 0.3 2.9e-40 138.0 0.3 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ran_BP1 PF00638.16 137200.1_16125120_2 - 9.3e-35 119.4 0.0 2.7e-34 117.9 0.0 1.8 1 0 0 1 1 1 1 RanBP1 domain zf-C3HC4_4 PF15227.4 137200.1_16125120_2 - 1.2e-13 50.8 12.1 1.2e-13 50.8 12.1 3.1 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 137200.1_16125120_2 - 8.7e-10 38.3 7.7 8.7e-10 38.3 7.7 3.0 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.23 137200.1_16125120_2 - 1.3e-08 34.4 8.9 1.3e-08 34.4 8.9 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 137200.1_16125120_2 - 1.4e-08 34.6 7.9 1.4e-08 34.6 7.9 5.1 6 1 0 6 6 4 1 B-box zinc finger zf-C3HC4_2 PF13923.4 137200.1_16125120_2 - 7.7e-08 31.9 10.7 7.7e-08 31.9 10.7 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 137200.1_16125120_2 - 1.2e-07 31.3 7.4 1.2e-07 31.3 7.4 3.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 137200.1_16125120_2 - 2e-05 24.6 10.0 2e-05 24.6 10.0 3.3 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.4 137200.1_16125120_2 - 0.00018 21.2 7.7 0.00018 21.2 7.7 3.0 2 1 0 2 2 1 1 zinc-RING finger domain Prok-RING_4 PF14447.4 137200.1_16125120_2 - 0.00057 19.6 6.6 0.00057 19.6 6.6 3.2 3 1 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.4 137200.1_16125120_2 - 0.011 15.4 5.7 0.036 13.8 5.7 1.9 1 0 0 1 1 1 0 zf-RING of BARD1-type protein U-box PF04564.13 137200.1_16125120_2 - 0.017 15.1 0.0 0.047 13.7 0.0 1.8 1 0 0 1 1 1 0 U-box domain WH1 PF00568.21 137200.1_16125120_2 - 0.063 13.1 0.1 0.13 12.0 0.1 1.6 1 0 0 1 1 1 0 WH1 domain Cation_efflux PF01545.19 001128234.1_16125001_2 - 3.1e-46 157.5 0.4 5.1e-46 156.8 0.4 1.3 1 0 0 1 1 1 1 Cation efflux family FAM176 PF14851.4 001128234.1_16125001_2 - 0.11 12.0 0.1 0.36 10.4 0.1 1.8 1 0 0 1 1 1 0 FAM176 family DUF4389 PF14333.4 001128234.1_16125001_2 - 0.6 9.9 3.0 0.5 10.2 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) SNARE PF05739.17 001128234.1_16125001_2 - 0.9 9.5 3.0 6.5 6.7 0.2 3.0 2 0 0 2 2 2 0 SNARE domain LRR_8 PF13855.4 001328605.1_16126001_2 - 1.9e-40 136.3 43.7 2.3e-08 33.6 0.2 9.6 7 3 3 10 10 10 9 Leucine rich repeat LRR_4 PF12799.5 001328605.1_16126001_2 - 6e-26 89.9 46.5 1.9e-06 27.9 2.9 10.5 6 2 7 13 13 13 8 Leucine Rich repeats (2 copies) TIR PF01582.18 001328605.1_16126001_2 - 7.7e-25 87.6 0.6 1.2e-24 86.9 0.6 1.3 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.4 001328605.1_16126001_2 - 5.9e-10 39.3 0.0 1.1e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.31 001328605.1_16126001_2 - 1.9e-09 36.5 39.2 0.65 10.6 0.1 13.7 14 2 0 14 14 14 3 Leucine Rich Repeat LRR_5 PF13306.4 001328605.1_16126001_2 - 2.7e-09 36.9 14.3 0.0017 18.1 0.1 4.9 2 2 3 5 5 5 3 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001328605.1_16126001_2 - 8.8e-07 28.5 17.6 0.0012 18.3 1.1 4.9 3 2 2 5 5 5 4 Leucine-rich repeat LRR_6 PF13516.4 001328605.1_16126001_2 - 8.9e-07 28.3 26.4 8.7 6.6 0.0 11.6 12 0 0 12 12 12 4 Leucine Rich repeat DUF1863 PF08937.9 001328605.1_16126001_2 - 0.00035 20.7 0.1 0.00069 19.8 0.1 1.5 1 0 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) Amidase_2 PF01510.23 001045222.2_16124001_2 - 5.9e-12 46.0 0.1 1.1e-11 45.1 0.1 1.5 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase IRF-3 PF10401.7 001327817.1_16125001_1 - 6e-69 231.3 0.0 8.8e-69 230.8 0.0 1.3 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.15 001327817.1_16125001_1 - 1.8e-41 140.6 0.1 2.6e-41 140.0 0.1 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor Orn_Arg_deC_N PF02784.14 001017568.3_16126001_3 - 1.9e-53 181.3 0.0 2.5e-53 181.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001017568.3_16126001_3 - 8.8e-14 51.4 0.0 1.9e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain CUB PF00431.18 001040243.1_16123001_1 - 4.2e-33 113.9 0.0 6.3e-33 113.3 0.0 1.3 1 0 0 1 1 1 1 CUB domain Xlink PF00193.15 001040243.1_16123001_1 - 7.9e-30 103.0 0.1 1.2e-29 102.3 0.1 1.3 1 0 0 1 1 1 1 Extracellular link domain Filament PF00038.19 001319237.1_16125001_2 - 9.4e-105 350.5 48.7 1.1e-104 350.2 48.7 1.1 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.12 001319237.1_16125001_2 - 6.8e-13 49.2 6.6 7.3e-12 45.9 6.4 2.3 2 0 0 2 2 2 1 Intermediate filament head (DNA binding) region GAS PF13851.4 001319237.1_16125001_2 - 0.0029 16.9 12.6 0.0029 16.9 12.6 2.8 2 1 0 2 2 2 1 Growth-arrest specific micro-tubule binding Baculo_PEP_C PF04513.10 001319237.1_16125001_2 - 0.02 14.8 8.2 1.8 8.5 0.3 3.6 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Trimer_CC PF08954.9 001319237.1_16125001_2 - 0.037 13.4 0.1 0.037 13.4 0.1 3.3 3 0 0 3 3 3 0 Trimerisation motif Reo_sigmaC PF04582.10 001319237.1_16125001_2 - 0.072 12.3 6.5 2.3 7.4 2.2 2.6 1 1 1 2 2 2 0 Reovirus sigma C capsid protein BRE1 PF08647.9 001319237.1_16125001_2 - 0.21 11.6 38.7 0.24 11.4 0.6 4.8 2 1 1 4 4 4 0 BRE1 E3 ubiquitin ligase HMMR_N PF15905.3 001319237.1_16125001_2 - 1.6 8.0 40.6 0.23 10.7 11.0 2.2 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF4618 PF15397.4 001319237.1_16125001_2 - 2 7.6 38.2 0.034 13.5 16.6 3.4 1 1 3 4 4 4 0 Domain of unknown function (DUF4618) Jnk-SapK_ap_N PF09744.7 001319237.1_16125001_2 - 2.1 8.4 48.6 0.56 10.3 15.3 3.3 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Spc7 PF08317.9 001319237.1_16125001_2 - 4.2 6.0 41.7 1.7 7.3 18.2 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein KMP11 PF03037.14 001319237.1_16125001_2 - 5.3 7.8 20.6 4.4 8.0 0.1 4.3 3 1 1 4 4 4 0 Kinetoplastid membrane protein 11 CENP-F_leu_zip PF10473.7 001319237.1_16125001_2 - 9.6 6.1 48.1 0.35 10.7 9.5 4.2 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EF-hand_1 PF00036.30 200718.1_16123001_1 - 7.1e-32 106.4 10.5 1.6e-06 27.1 0.3 5.4 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.4 200718.1_16123001_1 - 1.2e-29 99.5 11.0 1.1e-06 28.0 0.4 5.6 5 0 0 5 5 5 5 EF-hand domain EF-hand_7 PF13499.4 200718.1_16123001_1 - 1.1e-27 96.2 7.3 1.3e-09 38.2 0.3 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 200718.1_16123001_1 - 3.6e-21 73.5 12.0 4.6e-05 22.6 0.1 5.4 5 0 0 5 5 5 5 EF hand EF-hand_8 PF13833.4 200718.1_16123001_1 - 2.9e-10 39.6 7.3 0.0053 16.4 0.1 5.0 4 1 1 5 5 5 3 EF-hand domain pair GPHH PF16905.3 200718.1_16123001_1 - 0.00016 21.3 0.2 3.1 7.5 0.0 4.1 4 1 1 5 5 5 2 Voltage-dependent L-type calcium channel, IQ-associated Caleosin PF05042.11 200718.1_16123001_1 - 0.0021 17.8 2.7 1.8 8.3 0.1 3.6 2 2 2 4 4 4 2 Caleosin related protein SPARC_Ca_bdg PF10591.7 200718.1_16123001_1 - 0.011 16.0 1.6 9.4 6.5 0.0 3.8 1 1 2 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.4 200718.1_16123001_1 - 0.11 12.2 7.5 14 5.5 0.1 4.7 4 1 1 5 5 5 0 EF hand FAM176 PF14851.4 001008630.1_16123001_1 - 0.3 10.6 1.9 0.49 9.9 1.9 1.3 1 0 0 1 1 1 0 FAM176 family Thioredoxin_8 PF13905.4 001008630.1_16123001_2 - 7.7e-30 103.0 0.0 7.7e-30 103.0 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.19 001008630.1_16123001_2 - 9.6e-05 22.2 0.0 0.00018 21.3 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin PF00085.18 001008630.1_16123001_2 - 0.00031 20.5 7.9 0.0018 18.0 0.0 2.7 3 0 0 3 3 3 2 Thioredoxin SR-25 PF10500.7 001008630.1_16123001_2 - 1.6 8.1 38.8 2.6 7.4 38.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Connexin PF00029.17 001008630.1_16123001_3 - 0.0008 19.1 4.0 0.0013 18.4 4.0 1.4 1 0 0 1 1 1 1 Connexin ABC_export PF16962.3 001008630.1_16123001_3 - 0.018 13.4 3.6 0.024 12.9 3.6 1.1 1 0 0 1 1 1 0 Putative ABC exporter FAM176 PF14851.4 001008630.1_16123001_3 - 0.061 12.9 0.8 0.12 11.9 0.8 1.5 1 0 0 1 1 1 0 FAM176 family 7tm_1 PF00001.19 001008630.1_16123001_3 - 0.062 12.4 2.9 0.11 11.6 2.9 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) RNA_pol_Rpc4 PF05132.12 001008630.1_16123001_3 - 0.1 12.9 8.2 0.16 12.3 8.2 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 V_ATPase_I PF01496.17 001008630.1_16123001_3 - 0.13 10.0 3.9 0.17 9.6 3.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EIIBC-GUT_N PF03612.12 001008630.1_16123001_3 - 0.31 10.6 5.5 0.45 10.1 5.5 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus zf-RING_2 PF13639.4 213163.1_16129001_3 - 6e-12 45.5 7.4 6e-12 45.5 7.4 2.4 2 0 0 2 2 1 1 Ring finger domain CUE PF02845.14 213163.1_16129001_3 - 1.7e-10 40.3 0.1 3.2e-10 39.4 0.1 1.4 1 0 0 1 1 1 1 CUE domain zf-C3HC4_2 PF13923.4 213163.1_16129001_3 - 1.4e-09 37.5 6.4 3.9e-09 36.1 6.4 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 213163.1_16129001_3 - 1.3e-08 34.6 2.6 3.2e-08 33.3 2.6 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 213163.1_16129001_3 - 4.7e-08 32.6 5.3 1.1e-07 31.4 5.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 213163.1_16129001_3 - 3.4e-07 29.9 3.1 1e-06 28.3 3.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 213163.1_16129001_3 - 3.5e-06 27.1 10.2 4.7e-06 26.7 7.5 2.6 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.3 213163.1_16129001_3 - 4.5e-06 26.1 1.3 4.5e-06 26.1 1.3 2.8 3 0 0 3 3 3 1 RING-like zinc finger Prok-RING_4 PF14447.4 213163.1_16129001_3 - 1.3e-05 24.8 4.6 3.1e-05 23.6 4.6 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 213163.1_16129001_3 - 0.00011 21.9 3.6 0.00027 20.7 3.6 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.5 213163.1_16129001_3 - 0.00015 21.6 1.1 0.00051 19.9 1.1 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.3 213163.1_16129001_3 - 0.00018 20.9 4.2 0.00018 20.9 4.2 2.5 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.4 213163.1_16129001_3 - 0.011 15.8 4.2 0.026 14.5 4.2 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.5 213163.1_16129001_3 - 0.64 10.1 7.2 1.8 8.6 7.2 1.9 1 0 0 1 1 1 0 RING-variant domain Methyltransf_23 PF13489.4 001017842.2_16123001_3 - 1.1e-05 25.2 0.0 2.6e-05 24.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.4 001017842.2_16123001_3 - 0.00017 22.1 0.0 0.00069 20.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.10 001017842.2_16123001_3 - 0.00068 20.2 0.4 0.0018 18.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.10 001017842.2_16123001_3 - 0.0057 17.1 0.0 0.02 15.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.4 001017842.2_16123001_3 - 0.15 11.7 2.5 0.29 10.8 0.0 2.7 3 1 0 3 3 3 0 Methyltransferase domain YEATS PF03366.14 001040384.1_16127001_3 - 5.1e-26 90.3 0.0 9.7e-26 89.5 0.0 1.5 1 0 0 1 1 1 1 YEATS family BET PF17035.3 001040384.1_16127001_3 - 0.026 14.6 0.2 0.047 13.7 0.2 1.4 1 0 0 1 1 1 0 Bromodomain extra-terminal - transcription regulation Phospho_p8 PF10195.7 138548.1_16122120_3 - 3.9e-23 81.5 2.1 3.9e-23 81.5 2.1 1.8 2 0 0 2 2 2 1 DNA-binding nuclear phosphoprotein p8 7tm_1 PF00001.19 001278049.1_23526001_3 - 3.3e-47 160.8 25.3 3.3e-47 160.8 25.3 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) tRNA-synt_1g PF09334.9 001257372.1_23526001_1 - 3.2e-145 483.7 0.0 4e-145 483.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) WHEP-TRS PF00458.18 001257372.1_23526001_1 - 6.6e-13 48.5 0.1 1.2e-12 47.6 0.1 1.4 1 0 0 1 1 1 1 WHEP-TRS domain tRNA-synt_1 PF00133.20 001257372.1_23526001_1 - 9.1e-07 27.4 0.2 0.0025 16.0 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.11 001257372.1_23526001_1 - 0.0039 17.0 0.0 0.0068 16.2 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA GST_N_3 PF13417.4 001257372.1_23526001_1 - 0.065 13.5 0.0 0.21 11.8 0.0 1.9 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 001257372.1_23526001_1 - 0.12 12.4 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 001257372.1_23526001_1 - 0.15 11.9 0.1 0.15 11.9 0.1 2.4 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain TTSSLRR PF12468.6 001257372.1_23526001_1 - 1.1 9.4 4.2 9.4 6.4 1.6 3.1 3 0 0 3 3 3 0 Type III secretion system leucine rich repeat protein Med27 PF11571.6 001257372.1_23526001_1 - 1.8 8.9 4.7 1.9 8.8 0.9 2.5 1 1 1 2 2 2 0 Mediator complex subunit 27 zinc-ribbons_6 PF07191.10 001257372.1_23526001_1 - 2 8.4 7.2 0.63 9.9 3.6 2.0 1 1 0 1 1 1 0 zinc-ribbons C1_1 PF00130.20 001257372.1_23526001_1 - 2.2 8.1 7.9 16 5.4 2.9 2.5 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RHD_dimer PF16179.3 001199000.2_23529001_3 - 1.9e-27 95.2 0.2 4.7e-27 93.9 0.2 1.8 1 0 0 1 1 1 1 Rel homology dimerisation domain RHD_DNA_bind PF00554.20 001199000.2_23529001_3 - 6.8e-21 74.8 0.2 3.5e-20 72.5 0.2 2.3 1 1 0 1 1 1 1 Rel homology DNA-binding domain Trypsin PF00089.24 001103202.2_23522001_1 - 4.5e-69 232.5 6.9 5.2e-69 232.3 6.9 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001103202.2_23522001_1 - 4.4e-08 34.0 0.4 8.6e-08 33.0 0.4 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001103202.2_23522001_1 - 0.065 13.5 0.1 0.15 12.3 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) GHL10 PF02638.13 001103202.2_23522001_1 - 0.081 11.9 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase-like 10 zf-C2H2 PF00096.24 001099356.2_23524001_2 - 7.4e-18 63.8 35.6 0.00025 21.2 0.6 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001099356.2_23524001_2 - 7.8e-10 38.6 33.6 0.021 15.5 0.4 5.6 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001099356.2_23524001_2 - 1.1e-09 38.2 36.4 5.2e-05 23.4 0.3 5.1 5 1 1 6 6 5 3 Zinc-finger double domain zf-C2H2_8 PF15909.3 001099356.2_23524001_2 - 4.4e-06 26.8 7.4 4.4e-06 26.8 7.4 2.5 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-C2H2_6 PF13912.4 001099356.2_23524001_2 - 0.03 14.2 0.6 0.03 14.2 0.6 6.0 6 1 0 6 6 6 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001099356.2_23524001_2 - 0.078 13.0 15.1 0.12 12.3 0.1 4.1 4 1 0 4 4 4 0 Zinc ribbon domain zf-C2H2_7 PF15269.4 001099356.2_23524001_2 - 0.09 12.7 0.2 0.09 12.7 0.2 3.3 3 1 0 3 3 2 0 Zinc-finger zf-met PF12874.5 001099356.2_23524001_2 - 0.23 11.8 22.2 3.8 7.9 0.2 5.4 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001099356.2_23524001_2 - 0.29 11.4 0.1 0.29 11.4 0.1 4.5 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 001099356.2_23524001_2 - 0.35 10.5 8.7 0.33 10.6 1.0 3.5 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-LYAR PF08790.9 001099356.2_23524001_2 - 2.7 7.8 11.8 1.7 8.5 0.7 3.5 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Calponin PF00402.16 001354671.1_23524001_1 - 2.4e-44 148.4 16.8 2.2e-16 59.0 1.8 3.5 3 0 0 3 3 3 3 Calponin family repeat CH PF00307.29 001354671.1_23524001_1 - 3.3e-22 78.6 0.1 4.9e-22 78.1 0.1 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain Fox-1_C PF12414.6 001354671.1_23524001_1 - 0.043 14.0 0.4 4.7 7.5 0.2 2.4 2 0 0 2 2 2 0 Calcitonin gene-related peptide regulator C terminal CMS1 PF14617.4 001006048.2_16123001_2 - 1e-30 106.8 17.2 4e-30 104.9 17.2 2.1 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.27 001006048.2_16123001_2 - 7.4e-07 29.0 2.2 2.6e-06 27.2 2.1 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase NAD_binding_6 PF08030.10 001006048.2_16123001_2 - 0.0088 16.0 1.2 0.017 15.1 1.2 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain MCM_bind PF09739.7 001006048.2_16123001_2 - 0.26 9.6 8.0 0.34 9.2 8.0 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor LYRIC PF15686.3 001006048.2_16123001_2 - 0.76 9.1 17.1 1.3 8.3 17.1 1.3 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family 7tm_1 PF00001.19 131436.1_16123001_1 - 1e-51 175.6 20.6 1e-51 175.6 20.6 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 131436.1_16123001_1 - 2.9e-10 39.9 15.7 2.6e-09 36.7 15.7 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 131436.1_16123001_1 - 0.0013 18.0 20.3 0.0023 17.2 20.3 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Peptidase_A22B PF04258.11 131436.1_16123001_1 - 0.32 10.3 9.6 0.08 12.3 5.5 1.9 1 1 1 2 2 2 0 Signal peptide peptidase Git3 PF11710.6 131436.1_16123001_1 - 1.7 8.2 11.4 4.5 6.9 11.4 1.8 1 1 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 Adipogenin PF15202.4 131436.1_16123001_1 - 9.4 6.2 10.9 10 6.1 0.1 3.1 3 0 0 3 3 3 0 Adipogenin 7tm_1 PF00001.19 001089430.2_16126001_1 - 1.2e-46 159.0 23.6 1.2e-46 159.0 23.6 2.5 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) MORN PF02493.18 001002456.1_16124001_1 - 2.1e-07 30.3 19.3 0.0023 17.6 1.6 5.4 6 0 0 6 6 6 3 MORN repeat SET PF00856.26 001002456.1_16124001_1 - 8e-07 29.5 0.2 2.5e-06 27.9 0.2 1.7 1 1 0 1 1 1 1 SET domain Peptidase_C14 PF00656.20 001005973.1_16123001_1 - 3.3e-43 148.3 0.0 3.9e-43 148.1 0.0 1.0 1 0 0 1 1 1 1 Caspase domain DSPc PF00782.18 201171.1_16124001_1 - 5.2e-46 155.6 0.1 1e-45 154.7 0.1 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.18 201171.1_16124001_1 - 2.3e-12 47.2 0.0 1.1e-10 41.9 0.0 2.2 2 0 0 2 2 2 1 Rhodanese-like domain Y_phosphatase PF00102.25 201171.1_16124001_1 - 3e-05 23.6 0.0 4.7e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Homeobox PF00046.27 130940.3_16126001_1 - 4.1e-20 71.2 1.9 8.8e-20 70.2 1.9 1.6 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 130940.3_16126001_1 - 3.5 7.5 7.0 0.41 10.4 0.1 2.9 3 0 0 3 3 3 0 Homeobox KN domain Peptidase_C14 PF00656.20 001098619.1_16122001_1 - 2.1e-43 149.0 0.3 2.1e-43 149.0 0.3 1.4 2 0 0 2 2 2 1 Caspase domain XRCC4 PF06632.10 001098619.1_16122001_1 - 2.2 6.9 9.6 1.1 7.9 7.6 1.5 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Hormone_recep PF00104.28 214779.2_16125001_2 - 7.1e-36 123.6 3.7 9.6e-36 123.2 3.7 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 214779.2_16125001_2 - 9.7e-30 102.7 11.9 2.3e-29 101.5 11.9 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) RseA_C PF03873.11 214779.2_16125001_2 - 0.037 14.1 0.5 0.18 12.0 0.5 2.2 1 0 0 1 1 1 0 Anti sigma-E protein RseA, C-terminal domain Ras PF00071.20 001005931.2_16125001_2 - 6.4e-57 191.5 0.2 8.9e-57 191.1 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001005931.2_16125001_2 - 1.1e-18 67.4 0.0 2e-18 66.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001005931.2_16125001_2 - 2.8e-08 33.3 0.0 4e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001005931.2_16125001_2 - 1.1e-05 24.9 0.0 1.8e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001005931.2_16125001_2 - 0.0022 17.9 0.0 0.0034 17.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.15 001005931.2_16125001_2 - 0.0041 16.8 1.8 0.016 14.8 0.1 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein DNA_primase_lrg PF04104.12 214782.2_16125001_1 - 1.3e-94 316.4 0.0 1.8e-94 316.0 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Topoisom_I PF01028.18 001044324.2_16128001_1 - 1.1e-101 338.7 3.9 1.1e-101 338.7 3.9 2.0 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.13 001044324.2_16128001_1 - 4.4e-99 330.1 5.4 4.4e-99 330.1 5.4 4.7 4 1 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.4 001044324.2_16128001_1 - 3.6e-34 116.4 0.1 2.7e-33 113.6 0.4 2.5 2 0 0 2 2 2 1 C-terminal topoisomerase domain MIP-T3 PF10243.7 001044324.2_16128001_1 - 8.3 4.9 67.8 0.0071 15.0 50.6 2.3 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 DNA_topoisoIV PF00521.18 001310015.1_16129001_1 - 3.7e-129 431.2 1.0 4.7e-129 430.9 0.1 1.6 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.3 001310015.1_16129001_1 - 2.9e-48 163.2 6.2 1e-47 161.4 6.2 2.1 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.23 001310015.1_16129001_1 - 7.9e-29 100.2 1.5 1.7e-28 99.2 1.5 1.5 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.24 001310015.1_16129001_1 - 1.2e-15 57.9 0.1 5.5e-14 52.6 0.0 2.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DTHCT PF08070.9 001310015.1_16129001_1 - 4e-11 43.5 17.5 4e-11 43.5 17.5 6.1 2 1 4 6 6 6 2 DTHCT (NUC029) region Toprim PF01751.20 001310015.1_16129001_1 - 9.8e-09 35.2 0.0 3.4e-08 33.5 0.0 2.0 1 0 0 1 1 1 1 Toprim domain Ras PF00071.20 001039818.1_16123001_2 - 2.7e-54 183.0 0.0 3.6e-54 182.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001039818.1_16123001_2 - 6.3e-22 77.9 0.0 9.7e-22 77.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001039818.1_16123001_2 - 9.3e-08 31.6 0.0 1.3e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RIG-I_C-RD PF11648.6 001318408.1_23525001_1 - 2.1e-39 134.3 1.3 4.7e-39 133.2 1.3 1.6 1 0 0 1 1 1 1 C-terminal domain of RIG-I Helicase_C PF00271.29 001318408.1_23525001_1 - 9.4e-19 67.7 0.1 2.8e-17 62.9 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 001318408.1_23525001_1 - 3.6e-18 66.0 0.0 6.9e-18 65.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.27 001318408.1_23525001_1 - 1.3e-15 57.5 0.0 3.2e-15 56.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.4 001318408.1_23525001_1 - 0.00063 20.0 0.5 0.16 12.2 0.1 3.0 3 1 0 3 3 3 1 AAA domain AAA_11 PF13086.4 001318408.1_23525001_1 - 0.00088 18.9 0.2 1.8 8.1 0.2 2.9 1 1 1 2 2 2 2 AAA domain SNF2_N PF00176.21 001318408.1_23525001_1 - 0.0032 16.1 0.9 0.0084 14.7 0.1 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain SRP_TPR_like PF17004.3 001318408.1_23525001_1 - 0.024 14.5 0.0 0.065 13.1 0.0 1.7 1 0 0 1 1 1 0 Putative TPR-like repeat AAA_22 PF13401.4 001318408.1_23525001_1 - 0.039 14.1 0.4 0.18 11.9 0.1 2.4 2 0 0 2 2 2 0 AAA domain PXA PF02194.13 001163293.1_16127001_1 - 4.5e-29 101.3 2.0 9.3e-29 100.3 0.7 2.2 2 1 0 2 2 2 1 PXA domain Nexin_C PF08628.10 001163293.1_16127001_1 - 1e-25 90.4 0.9 4.2e-25 88.4 0.2 2.5 2 0 0 2 2 2 1 Sorting nexin C terminal RGS PF00615.17 001163293.1_16127001_1 - 2.4e-22 79.3 1.7 6e-22 78.0 0.6 2.4 2 0 0 2 2 2 1 Regulator of G protein signaling domain PX PF00787.22 001163293.1_16127001_1 - 8.4e-18 64.3 0.6 2.6e-17 62.7 0.1 2.2 2 0 0 2 2 2 1 PX domain Isy1 PF06246.10 001163293.1_16127001_1 - 0.0049 16.3 0.2 0.0049 16.3 0.2 2.4 2 0 0 2 2 2 1 Isy1-like splicing family PAS_3 PF08447.10 204807.2_23526001_3 - 1.1e-27 96.0 0.0 7.9e-21 74.0 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 204807.2_23526001_3 - 2e-22 79.3 0.3 2.7e-19 69.2 0.1 2.5 2 0 0 2 2 2 2 PAS domain HIF-1a_CTAD PF08778.8 204807.2_23526001_3 - 2.7e-19 68.3 1.0 6.9e-19 67.0 1.0 1.7 1 0 0 1 1 1 1 HIF-1 alpha C terminal transactivation domain HIF-1 PF11413.6 204807.2_23526001_3 - 1e-17 63.0 3.1 1.9e-17 62.2 2.1 2.0 2 0 0 2 2 2 1 Hypoxia-inducible factor-1 PAS PF00989.23 204807.2_23526001_3 - 7.7e-14 51.5 0.0 3.4e-06 26.9 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.5 204807.2_23526001_3 - 7e-09 35.8 0.1 0.0043 17.2 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 204807.2_23526001_3 - 2.1e-07 31.0 0.0 0.034 14.3 0.0 2.5 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 204807.2_23526001_3 - 0.036 13.9 0.2 0.072 12.9 0.2 1.5 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Calc_CGRP_IAPP PF00214.17 001113708.1_23522001_3 - 4.3e-29 101.2 0.1 6e-29 100.7 0.1 1.2 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family SLD5_C PF16922.3 001354864.1_23522001_1 - 8.2e-19 67.4 0.0 1.3e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.9 001354864.1_23522001_1 - 2.7e-06 27.7 0.3 4.8e-06 26.9 0.3 1.5 1 0 0 1 1 1 1 GINS complex protein Calc_CGRP_IAPP PF00214.17 001271965.1_23523001_3 - 6.4e-43 145.8 0.2 9.4e-43 145.3 0.2 1.3 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family cobW PF02492.17 001031436.1_23524001_1 - 3.5e-50 169.9 0.1 5.3e-50 169.3 0.1 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.12 001031436.1_23524001_1 - 2.1e-18 65.9 0.0 3.5e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain GTP_EFTU PF00009.25 001031436.1_23524001_1 - 2.9e-06 26.8 0.8 0.00055 19.4 0.2 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001031436.1_23524001_1 - 2.7e-05 24.0 0.1 0.12 12.1 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.4 001031436.1_23524001_1 - 0.012 15.8 0.0 0.027 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.21 001031436.1_23524001_1 - 0.015 15.3 0.0 0.18 11.8 0.0 2.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_23 PF13476.4 001031436.1_23524001_1 - 0.015 15.7 1.5 0.024 15.0 0.1 1.9 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.4 001031436.1_23524001_1 - 0.048 13.8 0.1 0.29 11.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.10 001031436.1_23524001_1 - 0.074 12.2 0.0 0.24 10.5 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin ABC_tran PF00005.25 001031436.1_23524001_1 - 0.075 13.4 0.1 0.14 12.5 0.1 1.6 1 1 0 1 1 1 0 ABC transporter AAA_18 PF13238.4 001031436.1_23524001_1 - 0.09 13.2 0.2 0.24 11.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.4 001031436.1_23524001_1 - 0.13 11.9 0.1 0.27 10.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain TNFR_c6 PF00020.16 001354724.1_23526001_1 - 6.5e-17 61.5 36.4 7.3e-07 29.4 10.7 3.7 3 0 0 3 3 3 3 TNFR/NGFR cysteine-rich region DUF4366 PF14283.4 001354724.1_23526001_1 - 0.2 11.0 0.0 0.35 10.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) OB_NTP_bind PF07717.14 001128544.2_16127001_1 - 6.1e-20 71.3 0.0 4.6e-18 65.2 0.0 2.5 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 001128544.2_16127001_1 - 4.5e-19 68.6 0.0 1.2e-18 67.2 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.29 001128544.2_16127001_1 - 5.7e-14 52.3 0.0 1.6e-13 50.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 001128544.2_16127001_1 - 4.2e-12 46.0 0.0 1.1e-11 44.6 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.4 001128544.2_16127001_1 - 0.00012 22.2 0.2 0.0023 18.1 0.1 2.6 2 0 0 2 2 2 1 AAA domain ATPase PF06745.11 001128544.2_16127001_1 - 0.011 15.0 0.0 0.02 14.1 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_19 PF13245.4 001128544.2_16127001_1 - 0.014 15.6 0.1 0.045 13.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.18 001128544.2_16127001_1 - 0.051 12.5 0.0 0.095 11.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.4 001128544.2_16127001_1 - 0.07 13.0 1.6 0.8 9.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.20 001128544.2_16127001_1 - 0.083 11.8 0.6 0.24 10.3 0.0 2.0 3 0 0 3 3 3 0 NB-ARC domain DUF1285 PF06938.9 001128544.2_16127001_1 - 0.11 12.4 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1285) AAA_23 PF13476.4 001128544.2_16127001_1 - 0.14 12.5 3.0 1.7 9.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Connexin PF00029.17 194420.1_16122001_1 - 2.2e-94 315.3 4.6 2.9e-94 314.9 4.6 1.1 1 0 0 1 1 1 1 Connexin Connexin PF00029.17 001128766.1_16122001_3 - 1.3e-92 309.5 1.3 1.7e-92 309.2 1.3 1.1 1 0 0 1 1 1 1 Connexin Exo_endo_phos PF03372.21 001122750.1_16125001_1 - 2.1e-06 27.8 0.0 4.2e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RRM_1 PF00076.20 200495.1_16124001_1 - 1e-33 114.8 0.1 1.9e-16 59.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 200495.1_16124001_1 - 6.5e-11 42.1 0.0 8.4e-06 25.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 200495.1_16124001_1 - 6e-05 22.8 0.1 0.075 12.9 0.1 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif DNA_ligase_IV PF11411.6 200495.1_16124001_1 - 0.12 12.4 0.2 1 9.3 0.0 2.4 2 0 0 2 2 2 0 DNA ligase IV IpaC_SipC PF09599.8 200495.1_16124001_2 - 0.3 10.4 9.4 0.43 9.9 9.4 1.2 1 0 0 1 1 1 0 Salmonella-Shigella invasin protein C (IpaC_SipC) Hormone_recep PF00104.28 001331156.1_16124001_3 - 7.1e-40 136.7 0.1 1.5e-39 135.7 0.0 1.5 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001331156.1_16124001_3 - 3.9e-29 100.8 18.6 6.7e-29 100.0 18.6 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) PV-1 PF06637.9 001114577.1_16125001_1 - 1.1e-15 57.2 14.8 1.1e-15 57.2 14.8 3.2 2 1 0 2 2 2 1 PV-1 protein (PLVAP) EphA2_TM PF14575.4 001114577.1_16125001_3 - 1.4 9.7 4.4 3.3 8.4 4.4 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Snf7 PF03357.19 001031529.1_23526001_1 - 2.4e-37 128.0 18.4 3.3e-37 127.6 18.4 1.1 1 0 0 1 1 1 1 Snf7 zf-RING_UBOX PF13445.4 001031320.1_23527001_1 - 1.4e-10 40.8 6.2 1.4e-10 40.8 6.2 3.4 3 0 0 3 3 3 1 RING-type zinc-finger zf-B_box PF00643.22 001031320.1_23527001_1 - 1.3e-07 31.5 1.5 1.3e-07 31.5 1.5 3.3 3 0 0 3 3 2 1 B-box zinc finger zf-C3HC4_2 PF13923.4 001031320.1_23527001_1 - 3.1e-07 30.0 1.8 3.1e-07 30.0 1.8 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001031320.1_23527001_1 - 7.3e-07 28.8 5.5 7.3e-07 28.8 5.5 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001031320.1_23527001_1 - 1e-06 28.7 7.5 1e-06 28.7 7.5 3.0 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_4 PF15227.4 001031320.1_23527001_1 - 5.5e-06 26.3 6.7 5.5e-06 26.3 6.7 3.7 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 001031320.1_23527001_1 - 7.1e-06 25.7 4.0 7.1e-06 25.7 4.0 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001031320.1_23527001_1 - 1.5e-05 24.8 4.6 1.5e-05 24.8 4.6 2.7 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.4 001031320.1_23527001_1 - 0.003 17.2 6.3 0.003 17.2 6.3 2.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 001031320.1_23527001_1 - 0.0098 15.9 0.9 0.0098 15.9 0.9 2.9 2 0 0 2 2 2 1 zinc RING finger of MSL2 U-box PF04564.13 001031320.1_23527001_1 - 0.017 15.1 0.1 0.076 13.1 0.1 2.0 1 1 0 1 1 1 0 U-box domain zf-RING_11 PF17123.3 001031320.1_23527001_1 - 0.1 12.2 5.4 0.49 10.0 5.4 2.3 1 0 0 1 1 1 0 RING-like zinc finger Aa_trans PF01490.16 001017644.1_16124001_1 - 2.7e-61 207.4 33.4 3.3e-61 207.1 33.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.11 001017644.1_16124001_1 - 7.4e-06 25.1 16.0 7.4e-06 25.1 16.0 1.7 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family SR-25 PF10500.7 001017644.1_16124001_1 - 9.5 5.6 14.6 1.4 8.3 5.6 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Acyltransferase PF01553.19 213270.2_16126001_3 - 2.7e-23 81.9 0.0 5.8e-23 80.9 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.3 213270.2_16126001_3 - 3.8e-14 52.5 0.0 7.3e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus ParA PF10609.7 001037114.2_16123001_2 - 5.7e-97 323.9 0.0 6.6e-97 323.6 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.21 001037114.2_16123001_2 - 3e-11 43.3 0.0 5.2e-10 39.3 0.0 2.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.9 001037114.2_16123001_2 - 3.1e-06 26.5 0.1 1.4e-05 24.4 0.1 1.9 1 1 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.4 001037114.2_16123001_2 - 3.5e-06 26.9 0.4 1.1e-05 25.3 0.4 1.8 1 1 0 1 1 1 1 AAA domain ArgK PF03308.14 001037114.2_16123001_2 - 3.7e-05 22.7 0.1 5.6e-05 22.1 0.1 1.2 1 0 0 1 1 1 1 ArgK protein ArsA_ATPase PF02374.13 001037114.2_16123001_2 - 0.00016 20.9 1.5 0.00049 19.3 0.4 2.1 2 1 0 2 2 2 1 Anion-transporting ATPase CBP_BcsQ PF06564.10 001037114.2_16123001_2 - 0.0002 20.8 0.0 0.00036 20.0 0.0 1.4 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.16 001037114.2_16123001_2 - 0.0034 16.7 0.1 0.0067 15.8 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_26 PF13500.4 001037114.2_16123001_2 - 0.0037 17.0 0.1 1.3 8.7 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.4 001037114.2_16123001_2 - 0.007 15.8 0.1 0.013 15.0 0.1 1.3 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.20 001037114.2_16123001_2 - 0.021 14.3 0.1 0.09 12.3 0.1 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_16 PF13191.4 001037114.2_16123001_2 - 0.039 14.2 0.1 0.062 13.5 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain KTI12 PF08433.8 001037114.2_16123001_2 - 0.068 12.5 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 APS_kinase PF01583.18 001037114.2_16123001_2 - 0.092 12.5 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase DUF258 PF03193.14 001037114.2_16123001_2 - 0.13 12.0 1.0 0.26 11.1 0.4 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_30 PF13604.4 001037114.2_16123001_2 - 0.15 11.6 0.2 0.3 10.6 0.2 1.4 1 0 0 1 1 1 0 AAA domain Peptidase_C12 PF01088.19 213084.1_16123001_1 - 1.9e-69 233.4 0.0 4.2e-69 232.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 HLH PF00010.24 204412.1_23524001_3 - 1.4e-16 60.0 0.3 5.7e-16 58.1 0.3 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain zf-CCHC PF00098.21 001326405.1_16124001_3 - 1.9e-38 128.7 76.8 1.3e-07 31.2 4.2 8.2 8 0 0 8 8 8 7 Zinc knuckle zf-CCHC_4 PF14392.4 001326405.1_16124001_3 - 2.6e-11 42.9 55.1 0.0098 15.4 0.9 7.7 7 1 1 8 8 8 7 Zinc knuckle zf-CCHC_5 PF14787.4 001326405.1_16124001_3 - 2e-10 40.1 40.8 0.013 15.0 0.8 6.9 5 2 2 7 7 7 6 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.4 001326405.1_16124001_3 - 0.00017 21.3 44.1 0.78 9.6 0.6 7.1 2 1 5 7 7 7 6 Zinc knuckle zf-CCHC_2 PF13696.4 001326405.1_16124001_3 - 0.0015 18.2 4.0 0.0015 18.2 4.0 6.8 7 0 0 7 7 7 3 Zinc knuckle Ion_trans PF00520.29 001030282.1_16126001_2 - 1.7e-34 119.1 16.7 2.6e-34 118.4 16.7 1.4 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.9 001030282.1_16126001_2 - 2.7e-24 85.0 2.0 5.3e-24 84.1 2.0 1.5 1 0 0 1 1 1 1 Transient receptor ion channel II PKD_channel PF08016.10 001030282.1_16126001_2 - 9.2e-14 50.8 11.8 1.8e-13 49.8 11.8 1.4 1 1 0 1 1 1 1 Polycystin cation channel Ank_2 PF12796.5 001030282.1_16126001_2 - 1.7e-10 41.2 0.1 2.7e-07 30.9 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001030282.1_16126001_2 - 2.1e-06 28.1 0.1 0.00025 21.4 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.4 001030282.1_16126001_2 - 1e-05 25.6 0.2 0.01 16.1 0.0 3.8 2 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.28 001030282.1_16126001_2 - 0.0054 17.0 1.2 15 6.1 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.4 001030282.1_16126001_2 - 0.013 15.8 1.5 16 6.4 0.0 4.8 4 0 0 4 4 4 0 Ankyrin repeat ING PF12998.5 001030282.1_16126001_2 - 0.065 13.7 7.8 5.2 7.6 3.5 3.4 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding IRS PF02174.15 001199626.2_23526001_3 - 2e-24 85.3 0.1 3.7e-24 84.4 0.1 1.4 1 0 0 1 1 1 1 PTB domain (IRS-1 type) SNF2_N PF00176.21 001199657.1_23529001_1 - 1.4e-68 231.1 0.6 2.7e-68 230.1 0.6 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.4 001199657.1_23529001_1 - 5.9e-48 162.5 22.9 5.9e-48 162.5 22.9 3.6 3 0 0 3 3 3 1 DNA-binding domain Helicase_C PF00271.29 001199657.1_23529001_1 - 7.6e-18 64.8 0.5 2.6e-17 63.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 001199657.1_23529001_1 - 2.3e-07 30.8 6.0 7.6e-06 25.9 0.0 3.5 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit HDA2-3 PF11496.6 001199657.1_23529001_1 - 3.3e-06 26.3 0.1 3.3e-06 26.3 0.1 3.2 3 0 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 FGGY_N PF00370.19 001077803.3_16127001_1 - 1.7e-47 161.9 0.0 5.4e-46 157.0 0.0 2.1 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.14 001077803.3_16127001_1 - 1.9e-41 141.8 0.0 2.8e-41 141.3 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DUF4594 PF15266.4 001075106.2_16127001_3 - 2.4e-56 190.8 22.6 2.4e-56 190.8 22.6 4.9 4 2 1 5 5 5 1 Domain of unknown function (DUF4594) PROCN PF08083.9 200976.2_16129001_2 - 2.9e-236 783.6 8.0 2.9e-236 783.6 8.0 1.5 2 0 0 2 2 2 1 PROCN (NUC071) domain PRP8_domainIV PF12134.6 200976.2_16129001_2 - 2.4e-130 433.0 0.6 4e-130 432.2 0.6 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.7 200976.2_16129001_2 - 1.6e-93 310.7 4.3 5.1e-92 305.8 3.7 2.5 1 1 1 2 2 2 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.9 200976.2_16129001_2 - 3.3e-87 289.9 4.4 9.4e-87 288.5 4.4 1.8 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.7 200976.2_16129001_2 - 2.5e-74 247.6 0.0 5.1e-74 246.6 0.0 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.9 200976.2_16129001_2 - 1.8e-53 179.5 0.1 4.1e-53 178.4 0.1 1.7 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.7 200976.2_16129001_2 - 1.7e-48 162.8 0.6 4.3e-48 161.5 0.6 1.7 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.19 200976.2_16129001_2 - 3.3e-14 52.7 0.0 8.9e-14 51.4 0.0 1.8 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease HMA PF00403.24 001256633.3_16122001_2 - 1.5e-07 31.6 0.2 2.2e-07 31.1 0.2 1.3 1 0 0 1 1 1 1 Heavy-metal-associated domain T-box PF00907.20 130914.2_16125001_3 - 2.4e-80 269.0 0.2 3.4e-80 268.5 0.2 1.2 1 0 0 1 1 1 1 T-box MOZART2 PF12926.5 001316932.1_16124001_2 - 1.9e-45 152.3 0.7 3.3e-45 151.5 0.7 1.4 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated p31comet PF06581.10 001327828.1_16123001_1 - 3.7e-69 232.6 0.7 9.7e-69 231.3 0.1 1.8 2 0 0 2 2 2 1 Mad1 and Cdc20-bound-Mad2 binding zf-Sec23_Sec24 PF04810.13 001327828.1_16123001_1 - 0.4 10.6 3.1 0.89 9.5 3.1 1.6 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Pkinase PF00069.23 201175.3_16129001_1 - 3.4e-62 210.0 0.0 4.4e-62 209.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 201175.3_16129001_1 - 7.4e-48 163.0 0.1 1.1e-47 162.5 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.6 201175.3_16129001_1 - 2.7e-12 46.3 0.0 4.9e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C terminal Kinase-like PF14531.4 201175.3_16129001_1 - 0.00021 20.6 0.0 0.00032 20.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like YchF-GTPase_C PF06071.11 001281986.1_16124001_3 - 2.3e-40 136.5 0.6 2.3e-40 136.5 0.6 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.21 001281986.1_16124001_3 - 5.5e-06 26.3 3.6 0.00071 19.5 0.0 2.9 1 1 2 3 3 3 2 50S ribosome-binding GTPase TGS PF02824.19 001281986.1_16124001_3 - 0.0026 17.6 0.0 0.0075 16.2 0.0 1.7 2 0 0 2 2 2 1 TGS domain WD40 PF00400.30 213080.2_16125001_3 - 5.9e-28 96.4 19.5 9.8e-08 32.4 0.2 6.7 5 1 1 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 213080.2_16125001_3 - 1.3e-22 79.8 2.1 6.6e-08 32.6 0.3 4.8 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 213080.2_16125001_3 - 3.6e-07 29.3 0.4 0.04 12.8 0.0 3.7 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.4 213080.2_16125001_3 - 3.9e-05 23.0 0.4 0.0054 16.0 0.1 2.7 1 1 2 3 3 3 1 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.10 213080.2_16125001_3 - 0.00016 21.4 0.2 1.7 8.6 0.1 3.6 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat DPPIV_N PF00930.19 213080.2_16125001_3 - 0.083 11.5 0.0 3.7 6.1 0.0 2.5 3 0 0 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region IKI3 PF04762.10 213080.2_16125001_3 - 0.13 10.1 0.2 2.4 5.9 0.1 2.4 3 0 0 3 3 3 0 IKI3 family Bromodomain PF00439.23 001320131.1_16129001_1 - 2.2e-17 62.8 0.0 6.2e-17 61.3 0.0 1.8 1 0 0 1 1 1 1 Bromodomain MBD PF01429.17 001320131.1_16129001_1 - 5e-15 54.8 0.5 3.1e-14 52.3 0.2 2.3 2 0 0 2 2 2 1 Methyl-CpG binding domain PHD PF00628.27 001320131.1_16129001_1 - 5.4e-11 42.1 8.5 1.2e-10 41.0 8.5 1.6 1 0 0 1 1 1 1 PHD-finger WSD PF15613.4 001320131.1_16129001_1 - 2.1e-08 34.4 0.0 7.5e-06 26.2 0.0 4.2 5 0 0 5 5 5 2 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.15 001320131.1_16129001_1 - 2.4e-05 24.4 0.1 5.6e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 DDT domain TRAM_LAG1_CLN8 PF03798.14 001114723.2_16124001_2 - 2.8e-33 115.2 15.9 2.8e-33 115.2 15.9 2.3 3 0 0 3 3 3 1 TLC domain PC_rep PF01851.20 201184.2_16127001_1 - 8.4e-42 139.4 22.8 6.9e-09 35.6 0.0 8.0 8 0 0 8 8 7 7 Proteasome/cyclosome repeat HEAT_2 PF13646.4 201184.2_16127001_1 - 7e-21 74.3 0.6 4.1e-14 52.6 0.0 5.0 4 1 3 7 7 6 3 HEAT repeats HEAT PF02985.20 201184.2_16127001_1 - 2.2e-05 24.1 0.2 2.5 8.4 0.0 5.1 5 0 0 5 5 4 1 HEAT repeat XRCC4 PF06632.10 201184.2_16127001_1 - 0.0014 17.4 11.2 0.0041 15.9 0.0 2.3 2 0 0 2 2 2 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 HEAT_PBS PF03130.14 201184.2_16127001_1 - 0.0025 18.2 0.2 7.1 7.5 0.0 4.5 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat TAF4 PF05236.12 201184.2_16127001_1 - 0.0074 16.0 4.4 0.014 15.1 4.4 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family HEAT_EZ PF13513.4 201184.2_16127001_1 - 0.026 14.8 3.1 2.7 8.4 0.0 4.9 4 2 3 7 7 6 0 HEAT-like repeat Tim54 PF11711.6 201184.2_16127001_1 - 0.034 12.8 12.9 0.077 11.6 12.9 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.20 201184.2_16127001_1 - 0.084 11.9 0.2 0.19 10.8 0.2 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter DDHD PF02862.15 201184.2_16127001_1 - 0.085 12.8 0.5 0.21 11.6 0.2 1.8 2 0 0 2 2 2 0 DDHD domain PA26 PF04636.11 201184.2_16127001_1 - 0.13 11.0 1.1 0.22 10.3 1.1 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Cnd1 PF12717.5 201184.2_16127001_1 - 0.14 12.1 1.7 1.2 9.0 0.0 3.4 3 1 0 3 3 2 0 non-SMC mitotic condensation complex subunit 1 NARP1 PF12569.6 201184.2_16127001_1 - 0.49 9.1 17.4 0.98 8.1 17.4 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 GBP_C PF02841.12 201184.2_16127001_1 - 1.3 8.2 20.7 35 3.5 21.1 2.2 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain ATP-synt_E PF05680.10 201184.2_16127001_1 - 2 8.7 12.1 3.8e+02 1.4 15.4 2.7 2 0 0 2 2 2 0 ATP synthase E chain Presenilin PF01080.15 201184.2_16127001_1 - 2.1 6.9 5.7 3.8 6.0 5.7 1.3 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.10 201184.2_16127001_1 - 2.7 6.7 6.8 0.61 8.8 3.2 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Vfa1 PF08432.8 201184.2_16127001_1 - 2.7 8.1 22.9 0.46 10.7 15.9 2.6 2 1 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 PIEZO PF15917.3 201184.2_16127001_1 - 2.9 7.2 11.0 5.1 6.4 11.0 1.3 1 0 0 1 1 1 0 Piezo FAM176 PF14851.4 201184.2_16127001_1 - 3.5 7.2 7.7 6.3 6.3 6.6 1.9 2 0 0 2 2 2 0 FAM176 family Pox_Ag35 PF03286.12 201184.2_16127001_1 - 4.6 6.9 20.6 1.7 8.3 16.3 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein DUF2360 PF10152.7 201184.2_16127001_1 - 5.7 7.2 12.1 2.9 8.1 8.1 2.3 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) DUF1510 PF07423.9 201184.2_16127001_1 - 6 6.1 20.4 0.32 10.3 13.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) CDC27 PF09507.8 201184.2_16127001_1 - 7.1 5.8 24.0 0.23 10.7 16.9 1.9 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 RRM_1 PF00076.20 212645.2_16125001_2 - 1.6e-34 117.4 0.6 1e-17 63.6 0.4 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 212645.2_16125001_2 - 2e-10 40.5 0.2 3.8e-05 23.6 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 212645.2_16125001_2 - 3.9e-05 23.4 0.0 0.093 12.6 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.9 212645.2_16125001_2 - 0.041 13.8 0.7 1.2 9.1 0.6 2.2 2 0 0 2 2 2 0 RNA binding motif CCDC-167 PF15188.4 001328596.1_16122001_2 - 4.4e-28 97.3 5.0 6.3e-28 96.8 5.0 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 167 Complex1_49kDa PF00346.17 001020645.2_16124001_2 - 1e-127 424.8 0.0 1.3e-127 424.4 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.17 001020645.2_16124001_2 - 0.019 13.7 0.0 0.031 13.0 0.0 1.3 1 0 0 1 1 1 0 Nickel-dependent hydrogenase Complex1_LYR PF05347.13 001162376.2_23522001_3 - 2.9e-11 43.1 0.1 4.7e-11 42.4 0.1 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) DUF4462 PF14692.4 001278012.1_23521001_2 - 2.3 7.8 5.2 0.45 10.0 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4462) Ribosomal_L38e PF01781.16 001278012.1_23521001_3 - 2.4e-37 126.7 5.1 2.8e-37 126.5 5.1 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family OGFr_N PF04664.11 001311349.1_16129001_3 - 1.9e-103 344.4 4.4 2.7e-103 343.8 4.4 1.2 1 0 0 1 1 1 1 Opioid growth factor receptor (OGFr) conserved region Propep_M14 PF02244.14 001110021.2_16125001_2 - 2.6e-16 59.6 1.1 3.9e-16 59.1 1.1 1.3 1 0 0 1 1 1 1 Carboxypeptidase activation peptide Peptidase_M14 PF00246.22 001110021.2_16125001_3 - 5.6e-92 308.5 0.0 6.7e-92 308.2 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase RVT_1 PF00078.25 001110021.2_16125001_3 - 0.011 15.1 0.1 0.016 14.6 0.1 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Arf PF00025.19 199644.2_16124001_2 - 2.4e-57 193.1 0.0 3.2e-57 192.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 199644.2_16124001_2 - 1.1e-16 60.7 0.0 1.4e-16 60.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 199644.2_16124001_2 - 4.8e-16 58.9 0.0 6.7e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 199644.2_16124001_2 - 1.1e-11 44.3 0.0 1.7e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 199644.2_16124001_2 - 9.3e-06 25.6 0.1 1.4e-05 25.0 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.18 199644.2_16124001_2 - 0.00011 21.4 0.1 0.0012 17.9 0.0 2.0 1 1 1 2 2 2 1 G-protein alpha subunit Gtr1_RagA PF04670.10 199644.2_16124001_2 - 0.00048 19.4 0.0 0.00071 18.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 199644.2_16124001_2 - 0.0018 17.7 0.2 0.0043 16.5 0.1 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FAM195 PF14799.4 001045127.3_16123001_1 - 8.8e-33 112.6 0.2 1.3e-32 112.0 0.2 1.3 1 0 0 1 1 1 1 FAM195 family RIBIOP_C PF04950.10 001111150.2_16129001_2 - 6.2e-91 304.7 0.0 6.2e-91 304.7 0.0 2.8 4 0 0 4 4 4 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.10 001111150.2_16129001_2 - 4.8e-31 106.6 0.1 3.3e-30 103.9 0.0 2.6 2 0 0 2 2 2 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.25 001111150.2_16129001_2 - 0.0003 20.2 4.0 0.0044 16.4 0.0 3.6 4 0 0 4 4 4 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001111150.2_16129001_2 - 0.0029 17.6 0.0 0.011 15.7 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 001111150.2_16129001_2 - 0.0052 16.9 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 001111150.2_16129001_2 - 0.011 16.0 0.0 0.037 14.3 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.27 001111150.2_16129001_2 - 0.082 13.2 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.20 001111150.2_16129001_2 - 0.14 12.5 0.4 0.69 10.2 0.0 2.2 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.4 001111150.2_16129001_2 - 0.62 10.5 0.0 0.62 10.5 0.0 3.2 3 0 0 3 3 3 0 AAA domain PRP38 PF03371.13 001003483.2_16123001_2 - 6e-63 211.7 0.5 7.6e-63 211.4 0.5 1.1 1 0 0 1 1 1 1 PRP38 family PRP38_assoc PF12871.5 001003483.2_16123001_2 - 3.8e-08 33.6 42.5 3.8e-08 33.6 42.5 2.2 1 1 1 2 2 2 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term SRP-alpha_N PF04086.11 001003483.2_16123001_2 - 0.83 9.4 13.1 1 9.1 13.1 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal L6_membrane PF05805.10 001277831.1_23523001_3 - 1e-68 230.6 19.4 1.2e-68 230.3 19.4 1.1 1 0 0 1 1 1 1 L6 membrane protein EI24 PF07264.9 001277831.1_23523001_3 - 0.64 10.1 6.1 0.18 11.9 0.4 2.0 2 0 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) Leu_zip PF15294.4 001110284.2_16124001_3 - 0.0097 15.3 17.3 0.015 14.7 17.3 1.2 1 0 0 1 1 1 1 Leucine zipper CALCOCO1 PF07888.9 001110284.2_16124001_3 - 0.01 14.4 17.4 0.014 13.9 17.4 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like LNP1 PF15419.4 001110284.2_16124001_3 - 0.085 12.9 7.3 0.15 12.2 7.3 1.3 1 0 0 1 1 1 0 Leukemia NUP98 fusion partner 1 SPT16 PF08644.9 001110284.2_16124001_3 - 0.29 11.2 6.3 0.57 10.2 6.3 1.5 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) TMCO5 PF14992.4 001110284.2_16124001_3 - 0.43 10.0 18.8 0.69 9.3 18.8 1.2 1 0 0 1 1 1 0 TMCO5 family GidB PF02527.13 001110284.2_16124001_3 - 0.79 8.9 6.7 1 8.5 5.6 1.7 1 1 1 2 2 2 0 rRNA small subunit methyltransferase G CHDCT2 PF08074.9 001110284.2_16124001_3 - 2.3 8.2 8.9 3.7 7.6 8.9 1.3 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain Fib_alpha PF08702.8 001110284.2_16124001_3 - 2.6 8.1 13.2 5.3 7.1 13.2 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1501 PF07394.10 001110284.2_16124001_3 - 3.1 6.6 5.9 4.4 6.1 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) PRP1_N PF06424.10 001110284.2_16124001_3 - 3.1 8.1 6.9 6.1 7.2 6.9 1.5 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal TolA_bind_tri PF16331.3 001110284.2_16124001_3 - 3.9 7.5 18.3 0.073 13.0 6.9 2.3 2 0 0 2 2 2 0 TolA binding protein trimerisation Noelin-1 PF12308.6 001110284.2_16124001_3 - 5 7.0 9.8 0.51 10.2 3.6 2.1 1 1 1 2 2 2 0 Neurogenesis glycoprotein Spc7 PF08317.9 001110284.2_16124001_3 - 5.6 5.6 20.2 10 4.8 20.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF572 PF04502.11 205595.2_16123001_1 - 1.2e-96 324.0 2.3 1.9e-96 323.4 2.3 1.3 1 1 0 1 1 1 1 Family of unknown function (DUF572) ZZ PF00569.15 205595.2_16123001_1 - 0.56 9.9 3.9 4.4 7.1 0.3 2.4 2 0 0 2 2 2 0 Zinc finger, ZZ type zf-DHHC PF01529.18 200049.2_16123001_2 - 3.3e-35 121.0 12.0 3.3e-35 121.0 12.0 2.6 3 1 0 3 3 3 1 DHHC palmitoyltransferase bZIP_1 PF00170.19 001243038.1_16129001_1 - 1e-14 54.2 16.0 1.6e-14 53.6 16.0 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001243038.1_16129001_1 - 2.6e-07 30.5 14.2 6.1e-07 29.3 14.2 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 001243038.1_16129001_1 - 0.00015 22.0 10.4 0.00027 21.3 10.4 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor APG6 PF04111.10 001243038.1_16129001_1 - 0.22 10.7 4.4 0.34 10.1 4.4 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Jnk-SapK_ap_N PF09744.7 001243038.1_16129001_1 - 0.29 11.2 8.2 0.47 10.5 8.2 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 ADIP PF11559.6 001243038.1_16129001_1 - 0.52 10.2 10.8 0.84 9.6 10.8 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF724 PF05266.12 001243038.1_16129001_1 - 0.64 9.7 3.9 1 9.0 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TPR_MLP1_2 PF07926.10 001243038.1_16129001_1 - 0.85 9.6 10.0 1.2 9.0 10.0 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF3552 PF12072.6 001243038.1_16129001_1 - 6.3 6.0 9.1 9.3 5.5 9.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) zf-C2H2 PF00096.24 001347673.1_16129001_2 - 4.6e-20 70.7 96.1 0.0014 18.8 0.5 16.1 16 0 0 16 16 16 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001347673.1_16129001_2 - 4e-19 67.5 103.6 0.00084 19.8 0.5 16.7 17 0 0 17 17 17 11 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001347673.1_16129001_2 - 1e-16 60.2 10.5 3.8e-12 45.6 0.9 10.1 12 0 0 12 12 12 4 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 001347673.1_16129001_2 - 1.6e-06 28.2 42.0 0.033 14.4 0.0 9.7 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001347673.1_16129001_2 - 0.00056 20.1 47.4 0.0045 17.2 0.1 10.8 12 0 0 12 12 12 5 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 001347673.1_16129001_2 - 0.0039 17.4 1.4 0.0039 17.4 1.4 14.3 17 1 1 18 18 18 5 Zinc-finger double domain zf-Di19 PF05605.10 001347673.1_16129001_2 - 0.026 14.6 68.4 0.099 12.8 0.9 9.7 7 1 3 11 11 11 0 Drought induced 19 protein (Di19), zinc-binding WD40 PF00400.30 001256028.1_16125001_3 - 4.4e-16 58.9 16.7 0.04 14.7 0.0 7.4 6 1 1 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001256028.1_16125001_3 - 0.0047 17.1 0.0 5.4 7.3 0.0 4.3 2 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Lactonase PF10282.7 001256028.1_16125001_3 - 0.0067 15.6 0.0 0.014 14.6 0.0 1.4 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller F-box-like PF12937.5 001305546.1_16128001_3 - 5.8e-05 22.8 0.3 0.00013 21.6 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001305546.1_16128001_3 - 0.0043 16.8 0.1 0.011 15.5 0.1 1.6 1 0 0 1 1 1 1 F-box domain Prok-E2_B PF14461.4 001305546.1_16128001_3 - 0.051 13.1 0.2 0.1 12.2 0.2 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B Glyco_transf_29 PF00777.16 001291755.1_23529001_1 - 6.1e-69 232.3 0.0 7.8e-69 231.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) AIMP2_LysRS_bd PF16780.3 001291755.1_23529001_3 - 0.0022 17.5 0.0 0.023 14.3 0.0 2.4 2 0 0 2 2 2 1 AIMP2 lysyl-tRNA synthetase binding domain Homeobox PF00046.27 001305260.1_23524001_1 - 1.1e-20 73.1 5.8 2.1e-20 72.1 5.8 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001305260.1_23524001_1 - 0.088 12.6 0.4 0.088 12.6 0.4 2.1 2 0 0 2 2 2 0 Homeobox KN domain Mito_fiss_reg PF05308.9 001305260.1_23524001_1 - 0.19 11.6 10.3 0.42 10.5 10.3 1.6 1 0 0 1 1 1 0 Mitochondrial fission regulator PRIMA1 PF16101.3 001305260.1_23524001_1 - 0.32 10.9 8.3 0.74 9.7 8.3 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 RNase_H PF00075.22 001285912.1_37523001_2 - 3.7e-42 143.8 0.1 5.3e-42 143.3 0.1 1.2 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.14 001285912.1_37523001_2 - 8e-19 67.5 3.8 1.6e-18 66.5 3.8 1.6 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.4 001285912.1_37523001_2 - 4.6e-06 26.2 0.1 1e-05 25.1 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase-like HrpE PF06188.10 001285912.1_37523001_2 - 0.12 12.1 0.1 0.18 11.5 0.1 1.2 1 0 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E CTNNB1_binding PF08347.9 001206510.3_23528001_1 - 2.6e-100 334.6 2.7 2.6e-100 334.6 2.7 2.3 2 0 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.17 001206510.3_23528001_1 - 7.3e-22 77.4 1.0 1.6e-21 76.4 1.0 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001206510.3_23528001_1 - 6.7e-08 32.9 2.0 1.5e-07 31.7 2.0 1.6 1 0 0 1 1 1 1 HMG-box domain Ribonuclease_T2 PF00445.16 001030064.2_16123001_1 - 1.3e-57 194.9 4.2 1.7e-57 194.5 4.2 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family EF-hand_7 PF13499.4 001328504.1_16125001_2 - 2.5e-21 75.8 0.4 9.2e-16 58.0 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 001328504.1_16125001_2 - 5.2e-18 63.0 3.9 6.4e-06 25.2 0.1 3.7 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 001328504.1_16125001_2 - 4.7e-14 50.9 3.4 0.00036 20.1 0.1 3.8 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 001328504.1_16125001_2 - 1.6e-11 43.7 1.4 0.00013 21.5 0.0 3.1 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.4 001328504.1_16125001_2 - 6.5e-10 38.0 4.7 0.00013 21.2 0.1 3.2 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.7 001328504.1_16125001_2 - 0.00012 22.2 2.6 0.0033 17.6 0.4 3.2 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 001328504.1_16125001_2 - 0.0041 16.9 0.5 0.054 13.3 0.1 2.5 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand Frag1 PF10277.7 001076573.2_16123001_2 - 7.2e-27 94.2 4.0 9.1e-27 93.9 4.0 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family BAR PF03114.16 001114906.2_16124001_3 - 1.1e-52 179.0 9.1 4.3e-52 177.0 9.1 1.8 2 0 0 2 2 2 1 BAR domain RhoGAP PF00620.25 001114906.2_16124001_3 - 1e-42 145.4 0.1 3.8e-42 143.5 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain BAR_2 PF10455.7 001114906.2_16124001_3 - 0.0068 15.4 3.2 0.017 14.1 3.2 1.7 1 1 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking Atg14 PF10186.7 001114906.2_16124001_3 - 0.031 13.2 0.7 0.063 12.2 0.7 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Mod_r PF07200.11 001114906.2_16124001_3 - 6.2 6.8 9.4 19 5.2 0.0 2.9 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein T4_deiodinase PF00837.15 001279439.2_37524001_1 - 2e-90 302.1 0.4 3.4e-90 301.3 0.0 1.4 2 0 0 2 2 2 1 Iodothyronine deiodinase CENP-W PF15510.4 001326437.1_16123001_3 - 1.3e-16 60.5 3.0 2.1e-16 59.8 3.0 1.2 1 0 0 1 1 1 1 CENP-W protein TMA7 PF09072.8 001159834.3_16123001_1 - 1.8e-26 92.6 24.1 1.8e-26 92.6 24.1 2.1 2 0 0 2 2 2 1 Translation machinery associated TMA7 RrnaAD PF00398.18 001003556.3_16125001_2 - 5.5e-65 218.9 0.0 7.4e-65 218.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.4 001003556.3_16125001_2 - 4e-06 27.3 0.0 8.2e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001003556.3_16125001_2 - 0.00066 20.1 0.0 0.0012 19.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.17 001003556.3_16125001_2 - 0.0037 16.9 0.0 0.0059 16.2 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.18 001003556.3_16125001_2 - 0.026 13.7 0.0 0.041 13.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MTS PF05175.12 001003556.3_16125001_2 - 0.027 13.9 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_12 PF08242.10 001003556.3_16125001_2 - 0.032 14.8 0.0 0.062 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.4 001003556.3_16125001_2 - 0.048 13.4 0.0 0.085 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.4 001003556.3_16125001_2 - 0.05 13.3 0.0 0.08 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.5 001003556.3_16125001_2 - 0.094 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.16 001003556.3_16125001_2 - 0.099 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_4 PF02390.15 001003556.3_16125001_2 - 0.1 11.9 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Glyco_hydro_18 PF00704.26 001199634.1_23523001_3 - 7.4e-20 71.8 0.0 9.2e-20 71.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 COesterase PF00135.26 001044936.1_16124001_3 - 4.8e-157 523.8 0.0 5.6e-157 523.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001044936.1_16124001_3 - 2.9e-09 37.0 2.1 3e-08 33.6 2.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 001044936.1_16124001_3 - 4e-05 23.1 0.1 6.5e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.18 001044936.1_16124001_3 - 0.0035 16.9 0.8 0.022 14.3 0.4 2.3 2 1 0 2 2 2 1 Putative esterase LIM PF00412.20 001277723.1_23525001_3 - 8.1e-45 150.7 69.2 1.6e-12 47.3 6.9 5.6 5 0 0 5 5 5 5 LIM domain BC10 PF06726.10 131493.2_16123001_3 - 6.4e-26 90.2 10.0 1e-25 89.6 10.0 1.3 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 UDPGT PF00201.16 001172770.2_16124001_3 - 1.8e-186 620.7 0.0 2.2e-186 620.4 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001172770.2_16124001_3 - 2.3e-07 30.8 0.0 4.1e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain zf-H2C2_2 PF13465.4 001327863.1_16124001_1 - 3.2e-79 257.9 58.5 4.5e-11 42.6 0.4 11.1 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 001327863.1_16124001_1 - 9.8e-62 202.0 78.0 6.9e-08 32.4 3.0 10.9 11 0 0 11 11 11 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001327863.1_16124001_1 - 3.9e-41 136.0 65.1 8.1e-06 26.1 2.0 10.6 10 0 0 10 10 10 9 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001327863.1_16124001_1 - 2.4e-18 65.4 70.5 0.0018 17.8 0.3 10.5 11 0 0 11 11 10 7 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 001327863.1_16124001_1 - 2.1e-17 62.5 48.3 0.0037 17.0 0.6 9.8 10 0 0 10 10 9 7 C2H2-type zinc finger zf-H2C2_5 PF13909.4 001327863.1_16124001_1 - 1.2e-14 53.6 71.2 0.00076 19.1 0.1 11.4 10 3 0 10 10 10 7 C2H2-type zinc-finger domain zf-LYAR PF08790.9 001327863.1_16124001_1 - 1.1e-13 50.7 44.6 0.17 11.7 0.3 9.5 9 0 0 9 9 9 8 LYAR-type C2HC zinc finger zf-C2HE PF16278.3 001327863.1_16124001_1 - 1.9e-13 50.5 60.5 0.022 15.1 1.3 9.3 1 1 8 9 9 9 7 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.6 001327863.1_16124001_1 - 4.3e-13 49.1 23.1 0.064 13.5 0.0 9.4 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding GAGA PF09237.9 001327863.1_16124001_1 - 4.6e-12 45.4 20.9 0.043 13.5 0.1 7.8 1 1 7 8 8 8 5 GAGA factor ADK_lid PF05191.12 001327863.1_16124001_1 - 1.4e-08 34.5 22.1 0.39 10.7 0.7 7.8 3 2 5 8 8 8 4 Adenylate kinase, active site lid zf-trcl PF13451.4 001327863.1_16124001_1 - 1.1e-07 31.5 31.9 2.4 8.0 0.1 9.2 9 0 0 9 9 9 1 Probable zinc-ribbon domain HypA PF01155.17 001327863.1_16124001_1 - 1.5e-07 31.3 25.3 0.078 12.9 0.2 5.4 1 1 6 7 7 7 7 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.8 001327863.1_16124001_1 - 3.8e-07 30.0 33.1 0.11 12.5 0.5 6.7 1 1 8 9 9 9 6 Zinc ribbon domain zf-RING_7 PF02591.13 001327863.1_16124001_1 - 1.8e-06 27.9 25.3 1.4 9.0 0.0 9.1 8 1 1 9 9 9 1 C4-type zinc ribbon domain zinc_ribbon_15 PF17032.3 001327863.1_16124001_1 - 4.4e-06 27.2 30.3 0.43 11.2 2.0 5.6 1 1 4 6 6 6 5 zinc-ribbon family DUF3268 PF11672.6 001327863.1_16124001_1 - 3.6e-05 23.9 16.8 0.66 10.2 0.1 4.9 1 1 3 6 6 6 4 zinc-finger-containing domain zf-C2H2_9 PF16293.3 001327863.1_16124001_1 - 5e-05 22.9 25.0 0.61 9.8 0.1 7.9 8 0 0 8 8 8 2 C2H2 type zinc-finger (1 copy) zinc_ribbon_9 PF14369.4 001327863.1_16124001_1 - 0.0001 22.4 25.5 3.3 7.9 0.1 8.9 9 0 0 9 9 9 1 zinc-ribbon YhfH PF14149.4 001327863.1_16124001_1 - 0.00022 21.0 25.4 2.8 7.9 0.1 8.7 9 0 0 9 9 9 1 YhfH-like protein FYDLN_acid PF09538.8 001327863.1_16124001_1 - 0.00023 21.7 30.8 2.8 8.5 0.1 9.1 1 1 9 10 10 10 1 Protein of unknown function (FYDLN_acid) LIM PF00412.20 001327863.1_16124001_1 - 0.00028 20.9 41.0 3.1 8.0 0.1 8.7 2 1 6 8 8 8 1 LIM domain zf-C2H2_2 PF12756.5 001327863.1_16124001_1 - 0.00055 20.1 48.1 1.8 8.8 1.4 8.7 1 1 7 8 8 8 3 C2H2 type zinc-finger (2 copies) CpXC PF14353.4 001327863.1_16124001_1 - 0.00056 19.8 34.1 4.2 7.3 0.2 8.9 1 1 7 9 9 9 1 CpXC protein zf-Sec23_Sec24 PF04810.13 001327863.1_16124001_1 - 0.0015 18.4 40.6 0.87 9.6 0.1 9.2 4 3 6 10 10 10 2 Sec23/Sec24 zinc finger zf-AN1 PF01428.14 001327863.1_16124001_1 - 0.0082 16.2 50.1 3.5 7.7 0.3 9.4 7 2 2 9 9 9 1 AN1-like Zinc finger zf-met PF12874.5 001327863.1_16124001_1 - 0.023 15.0 66.3 0.026 14.8 1.6 9.6 9 0 0 9 9 9 0 Zinc-finger of C2H2 type HTH_18 PF12833.5 001327863.1_16124001_1 - 0.1 12.7 3.4 51 4.1 0.0 4.4 5 1 0 5 5 4 0 Helix-turn-helix domain zf-Di19 PF05605.10 001327863.1_16124001_1 - 0.13 12.4 36.7 0.048 13.8 2.9 6.1 1 1 7 8 8 8 0 Drought induced 19 protein (Di19), zinc-binding BolA PF01722.16 001327863.1_16124001_1 - 0.18 12.0 18.1 4.2 7.6 0.6 5.2 3 1 1 4 4 4 0 BolA-like protein TerY_C PF15616.4 001327863.1_16124001_1 - 0.18 11.8 20.7 0.77 9.7 1.4 4.1 1 1 4 5 5 5 0 TerY-C metal binding domain zf-C2H2_3 PF13878.4 001327863.1_16124001_1 - 0.39 10.5 52.0 0.23 11.2 1.1 9.7 2 1 8 10 10 10 0 zinc-finger of acetyl-transferase ESCO PknG_rubred PF16919.3 001327863.1_16124001_1 - 0.6 10.1 30.9 0.29 11.1 1.9 5.5 2 2 3 6 6 6 0 Protein kinase G rubredoxin domain Elf1 PF05129.11 001327863.1_16124001_1 - 2.2 8.3 37.8 2.3 8.2 3.2 6.5 1 1 7 8 8 8 0 Transcription elongation factor Elf1 like Prok-RING_1 PF14446.4 001327863.1_16124001_1 - 4.6 7.1 26.5 28 4.6 1.7 8.1 8 1 0 8 8 8 0 Prokaryotic RING finger family 1 zf-Mss51 PF13824.4 001327863.1_16124001_1 - 4.7 7.3 42.8 14 5.8 0.5 8.4 1 1 3 4 4 3 0 Zinc-finger of mitochondrial splicing suppressor 51 zinc_ribbon_4 PF13717.4 001327863.1_16124001_1 - 6.1 6.7 45.7 6.5 6.6 0.3 9.0 8 1 0 8 8 8 0 zinc-ribbon domain IBR PF01485.19 001327863.1_16124001_1 - 10 6.3 50.0 0.51 10.5 3.3 6.7 2 1 4 6 6 6 0 IBR domain, a half RING-finger domain C1-set PF07654.13 001327918.1_16123001_1 - 1.2e-14 54.4 0.0 6.2e-14 52.1 0.0 2.2 3 0 0 3 3 3 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001327918.1_16123001_1 - 0.0021 18.5 0.0 0.0094 16.4 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain TMEM154 PF15102.4 001327918.1_16123001_1 - 0.046 13.5 0.1 0.14 12.0 0.1 1.7 1 0 0 1 1 1 0 TMEM154 protein family C1-set PF07654.13 001327884.1_16124001_1 - 4.1e-12 46.3 0.0 1.2e-11 44.8 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain DUF2232 PF09991.7 001327884.1_16124001_1 - 0.074 12.1 0.1 0.26 10.3 0.0 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) MHC_I PF00129.16 001327884.1_16124001_1 - 0.12 11.8 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 Abhydrolase_6 PF12697.5 001328359.1_16123001_2 - 2.9e-18 67.2 0.0 5.2e-18 66.3 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 001328359.1_16123001_2 - 5e-18 65.5 0.0 1e-11 44.8 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 001328359.1_16123001_2 - 4.5e-14 52.2 0.1 8.4e-14 51.3 0.1 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF1057 PF06342.10 001328359.1_16123001_2 - 4.2e-05 22.6 0.0 6.2e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Ndr PF03096.12 001328359.1_16123001_2 - 0.0065 15.1 0.0 0.013 14.1 0.0 1.4 1 0 0 1 1 1 1 Ndr family Abhydrolase_5 PF12695.5 001328359.1_16123001_2 - 0.097 12.3 0.0 1.8 8.2 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family Thioesterase PF00975.18 001328359.1_16123001_2 - 0.14 12.1 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain UDPGT PF00201.16 001177340.2_16124001_2 - 5.2e-193 642.2 0.0 6.4e-193 642.0 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001177340.2_16124001_2 - 2.2e-07 30.9 0.0 4e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain SurE PF01975.15 001177340.2_16124001_2 - 0.002 17.8 0.0 0.0034 17.1 0.0 1.3 1 0 0 1 1 1 1 Survival protein SurE DUF4757 PF15949.3 001045444.2_16129001_1 - 2.8e-42 145.0 3.4 2.8e-42 145.0 3.4 4.4 4 0 0 4 4 4 2 Domain of unknown function (DUF4757) CH PF00307.29 001045444.2_16129001_1 - 1.2e-11 44.7 0.0 2.5e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain LIM PF00412.20 001045444.2_16129001_1 - 7.8e-07 29.1 6.3 2.4e-06 27.5 6.3 1.9 1 0 0 1 1 1 1 LIM domain PDZ_2 PF13180.4 001045444.2_16129001_1 - 1.7e-06 28.1 0.0 4.2e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.22 001045444.2_16129001_1 - 8.8e-06 25.9 0.0 1.9e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SDP_N PF12278.6 001045444.2_16129001_1 - 0.18 11.3 10.1 0.021 14.4 4.4 2.4 2 0 0 2 2 2 0 Sex determination protein N terminal 2-Hacid_dh_C PF02826.17 205685.2_16125001_2 - 2.7e-58 196.1 0.0 3.5e-58 195.7 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 205685.2_16125001_2 - 2.2e-21 75.8 0.0 3.9e-21 75.0 0.0 1.4 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 205685.2_16125001_2 - 0.0045 17.1 0.0 0.0066 16.5 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.15 205685.2_16125001_2 - 0.17 12.4 0.0 0.3 11.6 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent CRAL_TRIO PF00650.18 199731.2_16124001_3 - 4.3e-29 101.2 0.0 6.5e-29 100.6 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.13 199731.2_16124001_3 - 0.00096 19.2 0.4 0.00096 19.2 0.4 1.8 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain Forkhead PF00250.16 001039284.2_23526001_3 - 3.5e-33 113.7 0.0 9.6e-33 112.2 0.0 1.7 2 0 0 2 2 2 1 Forkhead domain Phosphodiest PF01663.20 001006422.2_23524001_1 - 4.4e-84 283.0 0.8 5.2e-84 282.7 0.8 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.21 001006422.2_23524001_1 - 9.6e-08 31.6 0.0 0.00032 20.1 0.0 2.3 1 1 1 2 2 2 2 Sulfatase Metalloenzyme PF01676.16 001006422.2_23524001_1 - 0.00098 18.4 0.0 0.0015 17.8 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF1501 PF07394.10 001006422.2_23524001_1 - 0.13 11.1 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Homeobox PF00046.27 001017712.2_16125001_3 - 6.4e-22 77.0 5.6 1.2e-21 76.2 5.6 1.4 1 0 0 1 1 1 1 Homeobox domain FMO-like PF00743.17 001197289.1_16124001_3 - 7.6e-66 222.5 0.0 3.6e-50 170.8 0.0 2.0 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 001197289.1_16124001_3 - 1.3e-14 54.0 0.1 7.4e-11 41.7 0.2 3.2 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.12 001197289.1_16124001_3 - 4.4e-11 42.4 0.0 2.1e-10 40.2 0.0 1.9 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 001197289.1_16124001_3 - 2.3e-10 40.0 0.0 3.8e-09 36.0 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.4 001197289.1_16124001_3 - 5e-06 26.5 0.2 0.0016 18.5 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001197289.1_16124001_3 - 0.00013 21.6 1.5 0.0058 16.2 0.4 2.9 2 1 1 3 3 3 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.19 001197289.1_16124001_3 - 0.00039 19.6 0.7 0.0049 16.1 0.1 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.15 001197289.1_16124001_3 - 0.00057 19.1 0.3 0.11 11.6 0.0 2.1 2 0 0 2 2 2 2 Thi4 family NAD_binding_9 PF13454.4 001197289.1_16124001_3 - 0.0016 18.4 1.3 0.022 14.6 0.2 3.0 2 1 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.12 001197289.1_16124001_3 - 0.0022 16.6 0.4 0.14 10.7 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.25 001197289.1_16124001_3 - 0.0035 17.7 0.1 0.14 12.6 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 001197289.1_16124001_3 - 0.0054 15.7 1.3 0.22 10.5 0.2 2.1 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.20 001197289.1_16124001_3 - 0.018 14.0 1.2 1.8 7.4 0.0 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A Lycopene_cycl PF05834.10 001197289.1_16124001_3 - 0.024 13.6 0.2 1.7 7.5 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein Shikimate_DH PF01488.18 001197289.1_16124001_3 - 0.026 14.5 0.1 4.9 7.1 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.17 001197289.1_16124001_3 - 0.32 10.1 1.3 1.5 7.9 0.1 2.0 2 0 0 2 2 2 0 FAD binding domain RIO1 PF01163.20 001006581.2_23525001_1 - 8e-54 182.0 1.1 1.8e-53 180.8 1.1 1.6 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.9 001006581.2_23525001_1 - 5.6e-32 109.7 0.3 1.5e-31 108.3 0.3 1.8 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.21 001006581.2_23525001_1 - 3.2e-09 36.9 1.7 1.2e-05 25.2 0.3 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.12 001006581.2_23525001_1 - 3.2e-07 29.8 2.3 3.1e-06 26.5 2.3 2.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.9 001006581.2_23525001_1 - 0.0056 16.2 0.0 0.01 15.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Glyoxalase_2 PF12681.5 001006581.2_23525001_1 - 0.56 10.0 4.0 0.45 10.3 0.1 2.5 2 1 0 2 2 2 0 Glyoxalase-like domain Tetrabrachion PF11401.6 001006581.2_23525001_2 - 0.11 12.4 0.1 0.26 11.2 0.1 1.5 1 0 0 1 1 1 0 Tetrabrachion TNFR_c6 PF00020.16 001326458.1_16124001_1 - 2.4e-13 50.1 43.5 1.9e-08 34.4 7.5 4.6 4 0 0 4 4 4 3 TNFR/NGFR cysteine-rich region Tmemb_185A PF10269.7 001199477.1_23522001_2 - 1.1e-12 48.1 2.8 1.6e-12 47.5 2.8 1.2 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein Phage_holin_3_6 PF07332.9 001199477.1_23522001_2 - 2.5 8.0 8.1 0.27 11.1 1.1 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III CoA_binding_3 PF13727.4 001199477.1_23522001_2 - 6.6 6.6 10.7 0.6 10.0 5.7 1.7 1 1 1 2 2 2 0 CoA-binding domain SGIII PF15467.4 001293278.2_23529001_2 - 5.7e-214 711.3 35.7 6.8e-214 711.1 35.7 1.0 1 0 0 1 1 1 1 Secretogranin-3 DUF2680 PF10925.6 001293278.2_23529001_2 - 0.00057 19.7 9.0 0.59 10.0 0.1 4.1 4 0 0 4 4 4 3 Protein of unknown function (DUF2680) Lge1 PF11488.6 001030737.2_23527001_1 - 2.8e-17 62.9 0.7 5.2e-17 62.0 0.7 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein LGE1 tRNA_edit PF04073.13 001030737.2_23527001_1 - 0.2 11.6 0.0 0.33 10.9 0.0 1.2 1 0 0 1 1 1 0 Aminoacyl-tRNA editing domain Homeobox PF00046.27 001080015.2_16128001_3 - 3.2e-06 26.7 0.1 9.1e-06 25.3 0.1 1.7 1 0 0 1 1 1 1 Homeobox domain PRP21_like_P PF12230.6 001080015.2_16128001_3 - 0.0011 18.8 2.7 0.15 11.8 0.1 3.7 3 1 1 4 4 4 1 Pre-mRNA splicing factor PRP21 like protein Homeobox_KN PF05920.9 001080015.2_16128001_3 - 0.015 15.0 0.0 0.045 13.5 0.0 1.8 1 0 0 1 1 1 0 Homeobox KN domain DUF2719 PF10891.6 001080015.2_16128001_3 - 0.33 10.7 4.2 2.2 8.1 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2719) DUF3364 PF11844.6 001080015.2_16128001_3 - 1.4 9.1 4.2 27 5.0 0.6 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3364) Rpr2 PF04032.14 001080015.2_16128001_3 - 3.2 8.0 15.2 0.45 10.8 1.3 3.8 4 0 0 4 4 4 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-C2H2_4 PF13894.4 001080015.2_16128001_3 - 7.1 7.6 60.9 4.7 8.2 0.7 10.4 10 0 0 10 10 10 0 C2H2-type zinc finger Nuc_sug_transp PF04142.13 001256043.2_16127001_1 - 1.2e-37 129.7 17.3 1.2e-37 129.7 17.3 1.4 2 0 0 2 2 2 1 Nucleotide-sugar transporter DUF4535 PF15054.4 001256043.2_16127001_1 - 5.6e-07 29.0 0.0 1.2e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4535) Ribosomal_L37e PF01907.17 001122763.1_23522001_2 - 1.5e-26 92.1 15.1 2.7e-26 91.4 15.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.5 001122763.1_23522001_2 - 0.014 15.3 2.1 0.022 14.7 2.1 1.3 1 0 0 1 1 1 0 Double zinc ribbon DWNN PF08783.9 001309641.1_16123001_2 - 1.2e-23 83.1 0.1 1.7e-23 82.6 0.1 1.2 1 0 0 1 1 1 1 DWNN domain DUF4516 PF14990.4 001135573.2_16122001_1 - 2.2e-25 87.9 1.6 3.2e-25 87.5 1.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4516) PDE6_gamma PF04868.10 001159826.2_16123001_2 - 3.6e-45 152.0 0.5 5e-45 151.5 0.5 1.2 1 0 0 1 1 1 1 Retinal cGMP phosphodiesterase, gamma subunit DUF4589 PF15252.4 001293207.1_23524001_2 - 4.5e-80 269.1 7.5 4.5e-80 269.1 7.5 3.2 3 1 0 3 3 3 1 Domain of unknown function (DUF4589) PDZ PF00595.22 212691.2_16126001_3 - 1.3e-18 66.9 1.0 4e-12 46.2 0.1 2.4 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 212691.2_16126001_3 - 4.2e-10 39.7 0.1 6.2e-07 29.5 0.0 2.3 1 1 1 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.4 212691.2_16126001_3 - 0.075 12.9 0.0 0.35 10.8 0.0 2.0 2 0 0 2 2 2 0 Tricorn protease PDZ domain Tim44 PF04280.13 001328585.1_16123001_2 - 1.2e-30 106.4 0.0 1.8e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 Tim44-like domain Med30 PF11315.6 001277436.1_23522001_3 - 6.1e-66 221.1 1.3 7.5e-66 220.8 1.3 1.1 1 0 0 1 1 1 1 Mediator complex subunit 30 Sigma70_ner PF04546.11 001277436.1_23522001_3 - 0.062 13.0 1.3 0.12 12.0 1.3 1.5 1 1 0 1 1 1 0 Sigma-70, non-essential region UPF0449 PF15136.4 001277436.1_23522001_3 - 0.7 10.3 2.5 1.8 8.9 2.5 1.9 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 NUDIX PF00293.26 001002107.2_16122001_3 - 3.6e-15 56.0 0.1 5.2e-15 55.5 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.4 001002107.2_16122001_3 - 0.0078 16.0 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain 5_nucleotid PF05761.12 001328500.1_16127001_3 - 1.3e-176 587.9 0.0 1.7e-176 587.5 0.0 1.2 1 0 0 1 1 1 1 5' nucleotidase family GDA1_CD39 PF01150.15 001305234.2_23525001_3 - 8.5e-62 209.0 0.0 1.9e-60 204.6 0.0 2.8 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family SSXT PF05030.10 199744.2_16125001_1 - 7.3e-30 102.3 1.9 1.2e-29 101.5 1.9 1.4 1 0 0 1 1 1 1 SSXT protein (N-terminal region) ZU5 PF00791.18 001199766.1_16128001_2 - 7e-09 35.8 0.1 1.6e-08 34.7 0.1 1.6 1 0 0 1 1 1 1 ZU5 domain Death PF00531.20 001199766.1_16128001_2 - 9.9e-06 25.5 0.2 0.31 11.1 0.0 3.2 2 1 1 3 3 3 2 Death domain SH3_2 PF07653.15 001199766.1_16128001_2 - 3.9e-05 23.1 0.0 6.9e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain C1-set PF07654.13 001327909.1_16124001_3 - 1.1e-12 48.1 0.0 3e-12 46.7 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001327909.1_16124001_3 - 0.00041 19.8 0.0 0.00063 19.2 0.0 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_3 PF13927.4 001327909.1_16124001_3 - 0.0049 17.3 0.0 0.01 16.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Peptidase_C28 PF05408.9 001327909.1_16124001_3 - 0.013 15.1 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Foot-and-mouth virus L-proteinase Pkinase PF00069.23 001008644.2_16129001_2 - 1.2e-44 152.6 0.0 1.2e-44 152.6 0.0 1.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 001008644.2_16129001_2 - 7.9e-26 90.8 0.0 7.9e-26 90.8 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.21 001008644.2_16129001_2 - 0.05 13.4 0.2 0.05 13.4 0.2 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family Activator_LAG-3 PF11498.6 001008644.2_16129001_2 - 0.19 10.5 74.3 0.27 10.0 74.3 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TFIIA PF03153.11 001008644.2_16129001_2 - 1.4 8.7 46.5 2.1 8.1 46.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NFRKB_winged PF14465.4 001243035.1_16129001_3 - 2.8e-35 120.5 0.5 8.9e-35 118.9 0.5 2.0 1 0 0 1 1 1 1 NFRKB Winged Helix-like NEAT PF05031.10 001243035.1_16129001_3 - 0.052 14.0 0.2 0.23 12.0 0.2 2.0 2 0 0 2 2 2 0 Iron Transport-associated domain ASXH PF13919.4 001243035.1_16129001_3 - 0.086 12.7 0.2 0.26 11.2 0.2 1.8 1 0 0 1 1 1 0 Asx homology domain Cadherin PF00028.15 001351716.1_16127001_3 - 4.4e-90 296.2 2.7 2.3e-21 75.9 0.1 7.2 7 0 0 7 7 7 7 Cadherin domain Cadherin_2 PF08266.10 001351716.1_16127001_3 - 6.9e-12 44.9 5.9 3.8e-06 26.5 0.2 6.8 7 1 0 7 7 7 2 Cadherin-like Cadherin_3 PF16184.3 001351716.1_16127001_3 - 0.0011 18.9 10.4 0.14 12.1 0.1 5.7 6 0 0 6 6 6 1 Cadherin-like He_PIG PF05345.10 001351716.1_16127001_3 - 0.036 14.1 1.2 5.8 7.1 0.0 3.8 4 0 0 4 4 4 0 Putative Ig domain PKD PF00801.18 001351716.1_16127001_3 - 0.045 13.5 0.0 37 4.1 0.0 4.1 4 0 0 4 4 4 0 PKD domain RIB43A PF05914.10 001243149.1_16123001_3 - 9.6e-113 376.6 57.0 1.1e-112 376.4 57.0 1.0 1 0 0 1 1 1 1 RIB43A Transcrip_reg PF01709.18 001082873.2_16123001_3 - 2.2e-61 207.2 0.0 2.7e-61 206.9 0.0 1.1 1 0 0 1 1 1 1 Transcriptional regulator ADH_zinc_N PF00107.24 001082873.2_16123001_3 - 0.085 12.6 0.0 0.29 10.9 0.0 1.7 2 0 0 2 2 2 0 Zinc-binding dehydrogenase CD99L2 PF12301.6 001328524.1_16129001_1 - 5.5e-59 199.1 9.4 8.9e-59 198.4 9.4 1.3 1 0 0 1 1 1 1 CD99 antigen like protein 2 XTBD PF11952.6 001012887.2_23527001_1 - 2.8e-26 90.9 0.1 1e-25 89.2 0.1 2.0 1 0 0 1 1 1 1 XRN-Two Binding Domain, XTBD R3H PF01424.20 001012887.2_23527001_1 - 4.2e-13 49.0 0.3 1e-12 47.7 0.3 1.7 1 0 0 1 1 1 1 R3H domain G-patch PF01585.21 001012887.2_23527001_1 - 6.5e-13 48.2 2.5 6.5e-13 48.2 2.5 2.1 2 0 0 2 2 2 1 G-patch domain dsrm PF00035.24 001012887.2_23527001_1 - 7.4e-08 32.8 2.2 0.017 15.7 0.0 3.4 4 0 0 4 4 4 2 Double-stranded RNA binding motif G-patch_2 PF12656.5 001012887.2_23527001_1 - 3.1e-05 23.8 0.9 0.00011 22.1 0.9 2.0 1 0 0 1 1 1 1 G-patch domain S8_pro-domain PF16470.3 001012887.2_23527001_1 - 0.046 14.4 0.3 0.17 12.6 0.3 2.0 1 0 0 1 1 1 0 Peptidase S8 pro-domain BRCT PF00533.24 001012887.2_23527001_1 - 0.088 13.1 0.3 0.79 10.0 0.0 2.7 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain DAP_epimerase PF01678.17 001012887.2_23527001_2 - 0.087 12.9 0.3 0.15 12.2 0.3 1.2 1 0 0 1 1 1 0 Diaminopimelate epimerase zf-C2H2 PF00096.24 001080607.2_16126001_1 - 8.4e-15 54.2 35.0 0.00051 20.2 0.3 6.2 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001080607.2_16126001_1 - 5.7e-12 45.4 22.2 4.6e-07 29.9 0.8 5.7 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 001080607.2_16126001_1 - 0.0019 18.7 40.1 0.0036 17.9 0.3 6.8 6 0 0 6 6 6 3 C2H2-type zinc finger EpoR_lig-bind PF09067.8 001080607.2_16126001_1 - 0.002 18.1 0.7 0.058 13.5 0.1 2.7 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding zf-met PF12874.5 001080607.2_16126001_1 - 0.0021 18.3 2.1 0.58 10.5 0.1 3.4 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.3 001080607.2_16126001_1 - 1.2 9.4 14.0 1 9.6 0.7 4.3 2 1 1 4 4 4 0 C2H2-type zinc ribbon Ndc1_Nup PF09531.8 001080607.2_16126001_3 - 2.5 6.5 5.7 4 5.9 5.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NNMT_PNMT_TEMT PF01234.15 001111246.2_16126001_1 - 5.6e-68 228.8 0.0 7.4e-68 228.4 0.0 1.1 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_12 PF08242.10 001111246.2_16126001_1 - 0.087 13.4 0.0 0.25 12.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain PI31_Prot_N PF11566.6 001012537.2_23527001_3 - 1.9e-11 43.9 0.0 3.4e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal F-box-like PF12937.5 001012537.2_23527001_3 - 2.6e-10 39.9 2.8 5.9e-10 38.7 2.8 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001012537.2_23527001_3 - 4.7e-05 23.0 1.3 0.00014 21.5 1.3 1.9 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.9 001012537.2_23527001_3 - 0.009 16.4 0.3 0.023 15.1 0.3 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box_4 PF15966.3 001012537.2_23527001_3 - 0.071 12.8 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 F-box tRNA-synt_1d PF00750.17 001278019.1_23525001_2 - 2.4e-94 316.0 3.3 3.2e-94 315.6 3.3 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.13 001278019.1_23525001_2 - 6.6e-21 74.6 1.2 9.1e-21 74.1 0.1 1.9 2 0 0 2 2 2 1 DALR anticodon binding domain tRNA-synt_1g PF09334.9 001278019.1_23525001_2 - 0.025 13.3 0.4 0.25 10.0 0.1 2.1 1 1 1 2 2 2 0 tRNA synthetases class I (M) DUF3631 PF12307.6 001278019.1_23525001_2 - 0.043 13.9 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3631) MULE PF10551.7 001326555.1_16123001_2 - 2.3e-05 24.7 0.1 4.6e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 MULE transposase domain Scm3 PF10384.7 001006255.2_23526001_2 - 0.041 13.5 0.0 0.15 11.7 0.0 2.0 1 0 0 1 1 1 0 Centromere protein Scm3 MARVEL PF01284.21 200667.2_16129001_1 - 5.8e-36 123.5 5.7 7.8e-36 123.1 1.6 2.6 2 0 0 2 2 2 1 Membrane-associating domain PDDEXK_1 PF12705.5 001277518.1_23525001_1 - 1.7e-06 28.0 0.1 1.2e-05 25.2 0.1 2.0 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily zf-C2H2_3 PF13878.4 001277518.1_23525001_2 - 0.23 11.2 1.8 0.51 10.1 1.8 1.6 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO RAI16-like PF10257.7 001328189.1_16129001_3 - 3.9e-139 463.4 2.1 3.9e-139 463.4 2.1 1.6 2 0 0 2 2 2 1 Retinoic acid induced 16-like protein C1q PF00386.19 001327749.1_16123001_1 - 1.5e-21 76.8 0.2 2.2e-21 76.3 0.2 1.3 1 0 0 1 1 1 1 C1q domain His_Phos_2 PF00328.20 001278077.1_23523001_2 - 5.7e-09 35.7 0.0 7.4e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) His_Phos_2 PF00328.20 001278077.1_23523001_3 - 1.7e-07 30.8 0.0 2e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) CD99L2 PF12301.6 001328523.1_16129001_1 - 7.2e-59 198.7 9.3 1.2e-58 198.0 9.3 1.3 1 0 0 1 1 1 1 CD99 antigen like protein 2 fn3 PF00041.19 204959.2_23529001_1 - 1.9e-77 255.6 0.9 1.1e-15 57.6 0.1 5.8 5 0 0 5 5 5 5 Fibronectin type III domain I-set PF07679.14 204959.2_23529001_1 - 1.2e-71 236.7 12.3 8.2e-20 70.5 0.1 8.0 8 0 0 8 8 8 7 Immunoglobulin I-set domain Ig_3 PF13927.4 204959.2_23529001_1 - 3.8e-45 152.3 8.0 4.1e-10 40.0 0.1 7.7 8 0 0 8 8 8 6 Immunoglobulin domain Ig_2 PF13895.4 204959.2_23529001_1 - 7.9e-35 118.9 2.4 1.1e-09 38.3 0.1 7.1 7 0 0 7 7 7 5 Immunoglobulin domain ig PF00047.23 204959.2_23529001_1 - 3.1e-19 68.8 12.7 0.0011 18.9 0.2 7.8 7 0 0 7 7 7 5 Immunoglobulin domain V-set PF07686.15 204959.2_23529001_1 - 5.6e-15 55.3 21.0 0.026 14.5 0.9 10.2 8 4 0 8 8 8 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 204959.2_23529001_1 - 8.1e-10 38.5 0.9 0.025 14.5 0.0 4.5 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain Tissue_fac PF01108.15 204959.2_23529001_1 - 7.8e-05 22.3 0.0 0.56 9.9 0.0 4.3 5 0 0 5 5 5 2 Tissue factor Receptor_2B4 PF11465.6 204959.2_23529001_1 - 0.001 19.1 1.8 2.5 8.2 0.0 5.5 5 0 0 5 5 5 1 Natural killer cell receptor 2B4 Tubulin PF00091.23 001326595.1_16124001_1 - 5e-67 225.8 0.0 7e-67 225.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001326595.1_16124001_1 - 3.6e-51 172.5 0.0 5.8e-51 171.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 001326595.1_16124001_1 - 0.0026 17.3 0.0 0.0053 16.3 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain ELMO_CED12 PF04727.11 001329874.1_16129001_2 - 5.8e-46 156.7 0.2 9.6e-46 156.0 0.2 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family Malic_M PF03949.13 001003627.2_16124001_2 - 1.4e-96 322.6 0.0 2.1e-96 322.0 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.17 001003627.2_16124001_2 - 1.5e-78 262.7 0.0 2.4e-78 262.0 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain TPX2_importin PF12214.6 001327745.1_16126001_1 - 2.5e-40 138.3 63.5 1.2e-34 119.8 16.2 6.3 3 3 2 5 5 5 3 Cell cycle regulated microtubule associated protein TPX2 PF06886.9 001327745.1_16126001_1 - 4.3e-12 46.0 21.4 4.3e-12 46.0 21.4 6.0 6 0 0 6 6 6 2 Targeting protein for Xklp2 (TPX2) Aurora-A_bind PF09041.8 001327745.1_16126001_1 - 0.07 13.1 0.0 0.2 11.6 0.0 1.8 1 0 0 1 1 1 0 Aurora-A binding V-SNARE PF05008.13 001327892.1_16122001_2 - 0.11 12.7 0.0 0.26 11.6 0.0 1.6 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus PWI PF01480.15 001199684.1_23529001_1 - 1.6e-13 50.6 0.2 2.8e-13 49.8 0.2 1.4 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.20 001199684.1_23529001_1 - 8.1e-09 35.0 0.0 1.4e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gla PF00594.18 001017637.2_16124001_2 - 3e-21 75.2 4.5 6.6e-21 74.1 4.5 1.6 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain WBP-1 PF11669.6 001017637.2_16124001_2 - 0.0077 16.7 0.2 0.63 10.6 0.0 2.5 2 0 0 2 2 2 1 WW domain-binding protein 1 I-set PF07679.14 001309824.1_16129001_3 - 1.3e-86 284.6 0.0 1.8e-19 69.5 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.4 001309824.1_16129001_3 - 9.8e-81 266.3 1.2 3.5e-16 59.4 0.0 5.8 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 001309824.1_16129001_3 - 3.1e-51 171.5 0.0 5.5e-11 42.5 0.0 5.8 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 001309824.1_16129001_3 - 3.4e-47 158.4 0.1 1e-09 38.3 0.0 5.8 5 0 0 5 5 5 5 Immunoglobulin domain fn3 PF00041.19 001309824.1_16129001_3 - 1.5e-34 118.1 3.6 2.4e-11 43.7 0.1 3.6 3 0 0 3 3 3 3 Fibronectin type III domain V-set PF07686.15 001309824.1_16129001_3 - 6.5e-27 93.7 8.0 5.4e-07 29.6 0.0 9.4 6 4 0 6 6 6 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 001309824.1_16129001_3 - 4.5e-17 61.8 4.5 0.018 15.0 0.0 6.2 6 0 0 6 6 6 5 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 001309824.1_16129001_3 - 1.7e-11 44.2 0.0 0.13 12.6 0.0 5.5 5 0 0 5 5 5 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Pur_ac_phosph_N PF16656.3 001309824.1_16129001_3 - 1.5e-09 38.2 0.4 0.037 14.5 0.0 4.0 3 1 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Ig_4 PF16680.3 001309824.1_16129001_3 - 7.9e-08 32.4 0.1 0.33 11.2 0.0 5.4 7 0 0 7 7 6 2 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 001309824.1_16129001_3 - 0.0016 18.3 0.2 0.63 10.0 0.0 3.8 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain IL6Ra-bind PF09240.8 001312661.1_23528001_1 - 1.7e-18 66.7 0.9 4.3e-18 65.4 0.9 1.7 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding fn3 PF00041.19 001312661.1_23528001_1 - 0.00025 21.2 0.0 0.00076 19.7 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III domain Fibrinogen_C PF00147.16 204989.2_23524001_1 - 4.3e-93 311.0 10.2 6.4e-93 310.5 10.2 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fib_alpha PF08702.8 204989.2_23524001_1 - 1.4e-40 138.7 9.7 1.9e-40 138.2 9.7 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family EzrA PF06160.10 204989.2_23524001_1 - 0.0003 19.0 8.3 0.00065 17.9 8.0 1.5 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA HAUS-augmin3 PF14932.4 204989.2_23524001_1 - 0.02 14.3 2.4 0.029 13.7 2.4 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 SlyX PF04102.10 204989.2_23524001_1 - 0.048 14.2 1.8 0.11 13.0 1.8 1.6 1 0 0 1 1 1 0 SlyX TMF_DNA_bd PF12329.6 204989.2_23524001_1 - 0.062 13.2 4.7 0.13 12.2 4.7 1.5 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding VGPC1_C PF16799.3 204989.2_23524001_1 - 0.088 12.7 1.1 0.27 11.1 1.1 1.8 1 0 0 1 1 1 0 C-terminal membrane-localisation domain of ion-channel, VCN1 IFT57 PF10498.7 204989.2_23524001_1 - 0.11 11.3 5.7 0.16 10.8 5.7 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF489 PF04356.10 204989.2_23524001_1 - 0.17 11.7 1.6 0.29 11.0 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF489) DUF2400 PF09674.8 204989.2_23524001_1 - 0.18 11.7 0.8 0.37 10.6 0.5 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2400) RsbU_N PF08673.8 204989.2_23524001_1 - 0.23 11.5 1.4 0.45 10.5 1.4 1.4 1 0 0 1 1 1 0 Phosphoserine phosphatase RsbU, N-terminal domain LPP PF04728.11 204989.2_23524001_1 - 0.3 11.3 0.9 0.7 10.2 0.1 1.8 2 0 0 2 2 2 0 Lipoprotein leucine-zipper GIT1_C PF12205.6 204989.2_23524001_1 - 0.31 11.1 8.1 1.5 8.8 0.6 2.2 1 1 1 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term Lzipper-MIP1 PF14389.4 204989.2_23524001_1 - 0.45 10.7 3.9 4.3 7.5 0.9 2.3 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 DUF2935 PF11155.6 204989.2_23524001_1 - 0.54 10.5 4.3 3.7 7.8 3.4 2.4 2 1 0 2 2 1 0 Domain of unknown function (DUF2935) DUF724 PF05266.12 204989.2_23524001_1 - 0.76 9.4 4.6 1.2 8.8 4.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) ABC_tran_CTD PF16326.3 204989.2_23524001_1 - 0.94 9.6 6.2 4 7.6 0.3 2.4 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF16 PF01519.14 204989.2_23524001_1 - 3 8.2 6.3 13 6.1 4.7 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 Lectin_C PF00059.19 001109844.2_16123001_3 - 2.6e-25 89.1 13.3 1.3e-12 48.2 4.9 2.1 2 0 0 2 2 2 2 Lectin C-type domain Xlink PF00193.15 001109844.2_16123001_3 - 0.024 14.9 2.9 3.1 8.1 0.0 2.9 2 1 0 2 2 2 0 Extracellular link domain SMC_N PF02463.17 204518.2_23529001_3 - 6.1e-72 241.5 27.0 1.6e-71 240.1 27.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.11 204518.2_23529001_3 - 8.9e-26 90.4 0.1 8.9e-26 90.4 0.1 2.1 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.4 204518.2_23529001_3 - 1.4e-12 47.9 7.3 2.1e-06 27.6 0.0 3.6 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.4 204518.2_23529001_3 - 1.6e-06 28.7 36.5 1.6e-06 28.7 36.5 7.2 2 2 2 4 4 4 1 AAA domain Spc7 PF08317.9 204518.2_23529001_3 - 6e-06 25.2 12.8 6e-06 25.2 12.8 6.5 3 2 3 7 7 7 4 Spc7 kinetochore protein AAA_29 PF13555.4 204518.2_23529001_3 - 2.6e-05 23.7 0.0 6e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain SHNi-TPR PF10516.7 204518.2_23529001_3 - 0.018 14.4 0.2 2.3 7.6 0.1 3.2 2 0 0 2 2 2 0 SHNi-TPR ABC_tran PF00005.25 204518.2_23529001_3 - 0.18 12.2 0.0 0.18 12.2 0.0 6.2 3 2 0 3 3 3 0 ABC transporter Vac_Fusion PF02346.14 204518.2_23529001_3 - 4 7.0 17.1 0.34 10.4 0.2 5.0 4 0 0 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 Lar_restr_allev PF14354.4 001320174.1_16124001_3 - 0.061 13.6 1.3 0.16 12.2 1.3 1.8 1 0 0 1 1 1 0 Restriction alleviation protein Lar Utp21 PF04192.10 001308831.1_16126001_3 - 5.9e-65 218.9 0.4 1e-64 218.1 0.4 1.4 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.30 001308831.1_16126001_3 - 2.4e-21 75.5 13.6 4.6e-09 36.6 0.1 8.7 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001308831.1_16126001_3 - 3.6e-13 49.5 0.1 0.0029 17.7 0.0 7.0 2 2 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.9 001308831.1_16126001_3 - 0.028 13.1 0.0 0.55 8.8 0.0 2.7 2 1 1 3 3 3 0 Nup133 N terminal like Cytochrom_D1 PF02239.14 001308831.1_16126001_3 - 0.061 11.7 0.0 0.11 10.9 0.0 1.3 1 0 0 1 1 1 0 Cytochrome D1 heme domain Ge1_WD40 PF16529.3 001308831.1_16126001_3 - 0.15 10.9 1.7 0.64 8.8 0.0 2.8 4 0 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Pkinase_Tyr PF07714.15 212843.2_16126001_2 - 1.3e-92 309.6 0.1 1.9e-92 309.1 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 212843.2_16126001_2 - 5.9e-52 176.5 0.1 9.7e-52 175.8 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 212843.2_16126001_2 - 1.2e-36 124.4 2.2 4.4e-19 68.2 0.1 2.6 2 0 0 2 2 2 2 SH2 domain Kdo PF06293.12 212843.2_16126001_2 - 0.0024 17.1 0.4 0.004 16.4 0.4 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Tim44 PF04280.13 200307.2_16123001_3 - 1.2e-30 106.4 0.0 1.6e-30 106.0 0.0 1.2 1 0 0 1 1 1 1 Tim44-like domain Septin PF00735.16 001327974.1_16125001_1 - 4.7e-111 370.4 3.4 6.1e-111 370.0 3.4 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 001327974.1_16125001_1 - 5.2e-08 32.8 0.0 9.1e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001327974.1_16125001_1 - 3.7e-06 26.8 0.7 1.8e-05 24.6 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001327974.1_16125001_1 - 8.5e-06 25.3 1.3 0.00033 20.1 0.2 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.14 001327974.1_16125001_1 - 3.4e-05 23.1 0.2 5.4e-05 22.5 0.2 1.3 1 0 0 1 1 1 1 AIG1 family Roc PF08477.11 001327974.1_16125001_1 - 0.00011 22.3 0.1 0.00023 21.3 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001327974.1_16125001_1 - 0.00021 20.8 0.1 0.00047 19.7 0.1 1.6 1 0 0 1 1 1 1 Ras family AAA_16 PF13191.4 001327974.1_16125001_1 - 0.0007 19.9 0.0 0.0014 18.9 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Dynamin_N PF00350.21 001327974.1_16125001_1 - 0.0011 19.0 1.9 0.077 12.9 0.5 2.5 1 1 0 2 2 2 1 Dynamin family AAA_22 PF13401.4 001327974.1_16125001_1 - 0.0035 17.5 0.0 0.0097 16.0 0.0 1.8 2 0 0 2 2 1 1 AAA domain ABC_tran PF00005.25 001327974.1_16125001_1 - 0.0074 16.7 0.2 0.023 15.1 0.0 1.8 2 0 0 2 2 1 1 ABC transporter AAA_24 PF13479.4 001327974.1_16125001_1 - 0.021 14.4 0.1 0.1 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain IIGP PF05049.11 001327974.1_16125001_1 - 0.04 12.9 0.3 0.11 11.4 0.0 1.8 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) FtsK_SpoIIIE PF01580.16 001327974.1_16125001_1 - 0.047 12.9 0.0 0.081 12.1 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family NB-ARC PF00931.20 001327974.1_16125001_1 - 0.05 12.5 0.1 0.098 11.5 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_29 PF13555.4 001327974.1_16125001_1 - 0.053 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.18 001327974.1_16125001_1 - 0.073 12.1 3.3 0.17 10.9 3.3 1.7 1 1 0 1 1 1 0 G-protein alpha subunit AAA_14 PF13173.4 001327974.1_16125001_1 - 0.092 12.7 0.1 0.19 11.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.24 001327974.1_16125001_1 - 0.097 12.2 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain MCM PF00493.21 001327974.1_16125001_1 - 0.16 10.9 0.4 0.35 9.8 0.0 1.6 2 0 0 2 2 2 0 MCM2/3/5 family Condensin2nSMC PF12422.6 001089492.3_16129001_3 - 2.9e-56 189.7 6.7 4.7e-56 189.0 1.8 3.6 4 1 0 4 4 4 1 Condensin II non structural maintenance of chromosomes subunit HEAT PF02985.20 001089492.3_16129001_3 - 2.3e-08 33.4 7.9 0.33 11.2 0.3 5.6 5 0 0 5 5 5 4 HEAT repeat HEAT_2 PF13646.4 001089492.3_16129001_3 - 3.7e-08 33.5 0.7 0.0014 18.8 0.1 3.7 2 1 0 2 2 2 2 HEAT repeats Cnd1 PF12717.5 001089492.3_16129001_3 - 0.0042 17.0 12.7 0.26 11.2 0.3 4.7 4 1 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 001089492.3_16129001_3 - 0.023 15.0 3.0 3 8.3 0.2 4.1 4 0 0 4 4 4 0 HEAT-like repeat TIP120 PF08623.8 001089492.3_16129001_3 - 0.056 13.1 0.3 0.19 11.4 0.0 2.0 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) AKAP2_C PF15304.4 001204200.1_16129001_3 - 5.2e-14 52.1 11.3 5.2e-14 52.1 11.3 3.3 2 1 1 3 3 3 1 A-kinase anchor protein 2 C-terminus FIIND PF13553.4 001302240.1_16127001_3 - 9.9e-30 103.6 0.6 2.1e-29 102.5 0.6 1.5 1 0 0 1 1 1 1 Function to find TPR_14 PF13428.4 001302240.1_16127001_3 - 3.9e-11 42.7 1.2 4.3e-05 23.9 0.0 5.1 4 1 1 5 5 4 1 Tetratricopeptide repeat CARD PF00619.19 001302240.1_16127001_3 - 1.7e-10 40.7 1.5 1.3e-09 37.8 0.5 2.6 2 0 0 2 2 2 1 Caspase recruitment domain TPR_1 PF00515.26 001302240.1_16127001_3 - 1.1e-09 37.6 11.5 0.03 14.0 0.1 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.15 001302240.1_16127001_3 - 3.5e-09 35.9 22.6 0.0018 18.1 0.1 8.4 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_17 PF13431.4 001302240.1_16127001_3 - 1.9e-08 34.0 6.1 0.69 10.3 0.0 6.0 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_19 PF14559.4 001302240.1_16127001_3 - 1.2e-07 32.0 8.9 0.0024 18.2 0.1 4.4 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.4 001302240.1_16127001_3 - 2.5e-07 30.8 13.1 6.3e-05 23.1 1.6 4.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.4 001302240.1_16127001_3 - 4.4e-06 26.2 17.9 0.0025 17.3 0.1 5.4 6 0 0 6 6 6 3 TPR repeat TPR_8 PF13181.4 001302240.1_16127001_3 - 4.4e-06 26.4 17.3 0.044 13.9 0.1 6.7 7 0 0 7 7 6 2 Tetratricopeptide repeat AIG1 PF04548.14 001302240.1_16127001_3 - 9.6e-06 24.9 0.6 2.5e-05 23.6 0.1 1.9 2 0 0 2 2 2 1 AIG1 family TPR_15 PF13429.4 001302240.1_16127001_3 - 8.3e-05 21.8 6.3 0.09 11.8 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.4 001302240.1_16127001_3 - 0.00033 20.4 0.3 0.024 14.5 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 001302240.1_16127001_3 - 0.00038 20.9 0.1 0.51 11.0 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat CARD_2 PF16739.3 001302240.1_16127001_3 - 0.00069 19.4 0.7 0.0028 17.5 0.7 2.2 1 0 0 1 1 1 1 Caspase recruitment domain TPR_10 PF13374.4 001302240.1_16127001_3 - 0.0018 18.0 7.5 0.31 10.8 0.3 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat GUCT PF08152.10 001302240.1_16127001_3 - 0.036 14.2 0.8 0.29 11.3 0.1 2.8 3 0 0 3 3 3 0 GUCT (NUC152) domain TPR_6 PF13174.4 001302240.1_16127001_3 - 0.046 14.2 6.3 0.5 11.0 0.1 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_20 PF14561.4 001302240.1_16127001_3 - 1 9.6 8.9 1.9 8.8 0.7 4.5 3 1 2 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.5 001302240.1_16127001_3 - 8.7 6.5 10.5 2.6 8.2 0.1 3.7 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Motile_Sperm PF00635.24 212647.2_16129001_3 - 3e-31 107.4 0.0 5.3e-31 106.6 0.0 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain DUF4515 PF14988.4 212647.2_16129001_3 - 0.031 14.0 3.0 0.049 13.4 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) GIT_CC PF16559.3 212647.2_16129001_3 - 0.033 14.1 0.9 0.064 13.2 0.9 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor ZapB PF06005.10 212647.2_16129001_3 - 0.035 14.4 0.4 0.076 13.3 0.4 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DUF972 PF06156.11 212647.2_16129001_3 - 0.075 13.5 0.5 0.15 12.5 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) bZIP_1 PF00170.19 212647.2_16129001_3 - 0.086 12.8 1.5 0.18 11.8 1.5 1.5 1 0 0 1 1 1 0 bZIP transcription factor Com_YlbF PF06133.9 212647.2_16129001_3 - 0.1 13.1 0.3 0.19 12.2 0.3 1.3 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA LcrG PF07216.10 212647.2_16129001_3 - 0.13 12.1 1.0 0.23 11.3 1.0 1.3 1 0 0 1 1 1 0 LcrG protein JAB PF01398.19 001031256.2_23523001_1 - 3.1e-32 110.9 0.1 6.5e-32 109.9 0.0 1.6 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.4 001031256.2_23523001_1 - 2.6e-15 56.7 1.3 4.2e-15 56.0 1.3 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.4 001031256.2_23523001_1 - 5.2e-06 26.1 0.0 8.6e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Phage_int_SAM_5 PF13102.4 001031256.2_23523001_1 - 0.0036 17.5 2.6 0.0057 16.8 2.6 1.2 1 0 0 1 1 1 1 Phage integrase SAM-like domain G-patch PF01585.21 001100138.3_16126001_1 - 1.5e-19 69.5 4.0 2.7e-19 68.6 4.0 1.5 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.20 001100138.3_16126001_1 - 2e-11 43.4 0.0 3.9e-05 23.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP PF00641.16 001100138.3_16126001_1 - 1.7e-10 39.9 1.1 3.2e-10 39.0 1.1 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others G-patch_2 PF12656.5 001100138.3_16126001_1 - 1.8e-09 37.4 2.8 1.8e-09 37.4 2.8 2.7 3 0 0 3 3 3 1 G-patch domain GSIII_N PF12437.6 001100138.3_16126001_1 - 0.027 14.0 0.6 0.054 13.0 0.6 1.4 1 0 0 1 1 1 0 Glutamine synthetase type III N terminal zf-C2H2_4 PF13894.4 001100138.3_16126001_1 - 0.073 13.8 0.1 0.25 12.1 0.1 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger RED_N PF07808.11 001100138.3_16126001_1 - 0.23 10.9 10.6 0.018 14.6 1.5 2.6 2 0 0 2 2 2 0 RED-like protein N-terminal region zf-C2H2 PF00096.24 001100138.3_16126001_1 - 1.3 9.5 3.3 0.63 10.5 0.2 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type NAD_kinase PF01513.19 001003465.2_16124001_3 - 2.3e-12 46.6 0.0 3.4e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.22 001003465.2_16124001_3 - 0.00068 19.1 0.0 0.0014 18.1 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain PHR PF08005.10 001145581.1_16125001_3 - 6.1e-45 153.4 1.9 6.1e-45 153.4 1.9 1.5 2 0 0 2 2 2 1 PHR domain BTB PF00651.29 001145581.1_16125001_3 - 1.1e-23 83.4 0.0 4.4e-23 81.5 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.13 001145581.1_16125001_3 - 3.6e-07 30.1 1.5 4.8e-07 29.7 0.4 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch Abhydrolase_1 PF00561.18 001198604.1_23523001_1 - 5.7e-08 32.6 0.0 9.2e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001198604.1_23523001_1 - 4.2e-05 24.1 0.0 6.2e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 001198604.1_23523001_1 - 0.0036 16.5 0.0 0.0051 16.0 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.12 001198604.1_23523001_1 - 0.0075 14.9 0.0 0.011 14.3 0.0 1.1 1 0 0 1 1 1 1 Ndr family Thioesterase PF00975.18 001198604.1_23523001_1 - 0.019 15.0 0.1 0.028 14.4 0.1 1.2 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_5 PF12695.5 001198604.1_23523001_1 - 0.14 11.8 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family SE PF08491.8 001194927.1_23526001_3 - 1.7e-111 371.6 0.1 2.1e-111 371.2 0.1 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.17 001194927.1_23526001_3 - 1.2e-19 70.7 0.0 1.9e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.22 001194927.1_23526001_3 - 1.5e-09 37.8 0.1 0.00017 21.2 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.25 001194927.1_23526001_3 - 0.00022 21.6 0.2 0.00044 20.6 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 001194927.1_23526001_3 - 0.00029 19.9 0.9 0.098 11.6 0.4 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.4 001194927.1_23526001_3 - 0.0003 20.8 0.3 0.00065 19.8 0.3 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.16 001194927.1_23526001_3 - 0.00061 19.6 0.1 0.00099 18.9 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.12 001194927.1_23526001_3 - 0.00086 18.5 0.0 0.0015 17.7 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.20 001194927.1_23526001_3 - 0.0037 16.3 0.0 0.0076 15.2 0.0 1.3 1 1 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.15 001194927.1_23526001_3 - 0.01 15.0 0.0 0.092 11.8 0.0 2.0 2 0 0 2 2 2 0 Thi4 family TrkA_N PF02254.16 001194927.1_23526001_3 - 0.012 15.8 0.2 0.02 15.0 0.2 1.4 1 0 0 1 1 1 0 TrkA-N domain GMC_oxred_N PF00732.17 001194927.1_23526001_3 - 0.014 14.7 0.0 1.8 7.8 0.0 2.2 2 0 0 2 2 2 0 GMC oxidoreductase NAD_Gly3P_dh_N PF01210.21 001194927.1_23526001_3 - 0.02 14.7 0.0 0.038 13.8 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.14 001194927.1_23526001_3 - 0.022 14.3 0.0 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.16 001194927.1_23526001_3 - 0.039 14.1 0.1 0.068 13.3 0.1 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.13 001194927.1_23526001_3 - 0.065 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Trp_halogenase PF04820.12 001194927.1_23526001_3 - 0.094 11.4 0.5 6.2 5.4 0.2 2.4 2 1 1 3 3 3 0 Tryptophan halogenase FAD_oxidored PF12831.5 001194927.1_23526001_3 - 0.12 11.5 0.1 0.19 10.9 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Shikimate_DH PF01488.18 001194927.1_23526001_3 - 0.17 11.8 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Lycopene_cycl PF05834.10 001194927.1_23526001_3 - 0.2 10.5 0.5 5.8 5.7 0.1 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein AAA PF00004.27 199750.2_16124001_1 - 2.8e-44 150.6 0.1 9.8e-44 148.8 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.12 199750.2_16124001_1 - 2.2e-08 34.3 0.0 6e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.12 199750.2_16124001_1 - 1.4e-07 31.4 0.1 4.4e-07 29.9 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 199750.2_16124001_1 - 5.7e-06 26.7 0.2 0.0011 19.3 0.0 2.6 2 1 0 3 3 2 1 AAA ATPase domain DUF815 PF05673.11 199750.2_16124001_1 - 0.00015 20.9 0.0 0.00062 18.9 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RuvB_N PF05496.10 199750.2_16124001_1 - 0.00016 20.9 0.0 0.0005 19.3 0.0 1.8 1 1 1 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus RNA_helicase PF00910.20 199750.2_16124001_1 - 0.00044 20.5 0.0 0.00098 19.4 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_22 PF13401.4 199750.2_16124001_1 - 0.00045 20.4 0.8 0.06 13.5 0.0 2.7 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.19 199750.2_16124001_1 - 0.0008 18.7 0.1 0.0017 17.7 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.4 199750.2_16124001_1 - 0.0012 18.7 0.1 0.0061 16.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.4 199750.2_16124001_1 - 0.0019 18.4 0.0 0.0038 17.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 199750.2_16124001_1 - 0.0026 17.8 0.0 0.0052 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.15 199750.2_16124001_1 - 0.0035 17.0 0.0 0.01 15.5 0.0 1.8 2 0 0 2 2 2 1 IstB-like ATP binding protein NTPase_1 PF03266.13 199750.2_16124001_1 - 0.0047 16.7 0.1 0.17 11.6 0.0 2.8 3 0 0 3 3 3 1 NTPase AAA_18 PF13238.4 199750.2_16124001_1 - 0.007 16.7 0.0 0.021 15.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain NACHT PF05729.10 199750.2_16124001_1 - 0.0075 16.1 0.1 0.052 13.3 0.0 2.2 2 0 0 2 2 2 1 NACHT domain Sigma54_activat PF00158.24 199750.2_16124001_1 - 0.0098 15.5 0.2 0.7 9.4 0.0 2.8 3 0 0 3 3 3 1 Sigma-54 interaction domain TIP49 PF06068.11 199750.2_16124001_1 - 0.0099 14.7 0.0 0.019 13.8 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_3 PF07726.9 199750.2_16124001_1 - 0.017 14.8 0.1 0.2 11.4 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.15 199750.2_16124001_1 - 0.02 14.8 0.0 0.05 13.5 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.16 199750.2_16124001_1 - 0.03 14.1 1.1 0.19 11.5 0.0 2.5 2 1 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_24 PF13479.4 199750.2_16124001_1 - 0.077 12.6 0.1 0.17 11.5 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.4 199750.2_16124001_1 - 0.08 12.4 1.9 0.15 11.4 0.1 2.1 2 1 1 3 3 3 0 AAA domain Zeta_toxin PF06414.10 199750.2_16124001_1 - 0.085 12.0 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin NB-ARC PF00931.20 199750.2_16124001_1 - 0.11 11.3 0.1 0.32 9.9 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain Parvo_NS1 PF01057.15 199750.2_16124001_1 - 0.12 11.3 0.0 0.21 10.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Rab15_effector PF15208.4 001326596.1_16122001_2 - 5.7e-36 123.9 0.0 7.3e-36 123.5 0.0 1.0 1 0 0 1 1 1 1 Rab15 effector QueF_N PF14819.4 001326596.1_16122001_2 - 0.13 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term PDZ PF00595.22 001256123.1_23529001_2 - 8.5e-191 618.8 66.0 1.3e-20 73.4 0.0 13.4 13 0 0 13 13 13 13 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001256123.1_23529001_2 - 7.7e-62 205.5 38.1 1.7e-05 24.9 0.0 13.8 13 0 0 13 13 13 12 PDZ domain L27_2 PF09045.8 001256123.1_23529001_2 - 4.5e-32 109.7 5.4 9.5e-32 108.6 5.4 1.6 1 0 0 1 1 1 1 L27_2 MPDZ_u10 PF16667.3 001256123.1_23529001_2 - 2.7e-23 82.5 13.7 2.7e-23 82.5 13.7 3.8 2 0 0 2 2 2 1 Unstructured region 10 on multiple PDZ protein L27_1 PF09058.8 001256123.1_23529001_2 - 0.00017 21.5 1.0 0.00017 21.5 1.0 2.1 2 0 0 2 2 2 1 L27_1 Chorion_2 PF03964.13 001256123.1_23529001_2 - 2 9.2 4.9 5.9 7.7 1.0 2.9 2 0 0 2 2 2 0 Chorion family 2 Kei1 PF08552.9 200431.2_16125001_3 - 0.17 11.4 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 HECT_2 PF09814.7 001326410.1_16124001_1 - 2.7e-69 233.7 0.3 3.2e-69 233.5 0.3 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding MIP PF00230.18 001293239.1_23529001_3 - 1e-44 152.8 13.7 1.5e-44 152.3 13.7 1.1 1 0 0 1 1 1 1 Major intrinsic protein Rad60-SLD_2 PF13881.4 212686.2_16125001_1 - 2.2e-30 104.9 0.0 4.1e-30 104.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.21 212686.2_16125001_1 - 0.018 14.6 0.0 0.04 13.5 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin family RRM_1 PF00076.20 001039268.2_23527001_3 - 2.4e-87 286.7 6.2 5.9e-19 67.5 0.0 6.4 6 0 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001039268.2_23527001_3 - 5.1e-10 39.2 0.2 0.33 11.0 0.0 5.7 6 0 0 6 6 6 4 RNA recognition motif RRM_occluded PF16842.3 001039268.2_23527001_3 - 5.5e-05 22.8 0.0 0.54 10.0 0.0 4.2 5 0 0 5 5 5 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.4 001039268.2_23527001_3 - 0.00038 20.2 0.5 31 4.5 0.0 5.0 5 0 0 5 5 5 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.6 001039268.2_23527001_3 - 0.0021 18.0 0.0 0.65 10.0 0.0 4.4 5 1 0 5 5 5 1 Limkain b1 MOZART2 PF12926.5 001316933.1_16124001_2 - 1.8e-45 152.3 0.7 3.3e-45 151.5 0.7 1.4 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated HD_3 PF13023.4 001277918.1_23522001_2 - 2.8e-48 163.8 0.8 3.4e-48 163.5 0.8 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.20 001277918.1_23522001_2 - 0.0006 19.9 0.4 0.0011 19.1 0.4 1.4 1 0 0 1 1 1 1 HD domain DUF4259 PF14078.4 001277918.1_23522001_2 - 0.34 11.5 2.4 0.5 11.0 2.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4259) GalKase_gal_bdg PF10509.7 001007432.2_16124001_2 - 8.7e-24 82.7 0.1 1.5e-23 81.9 0.1 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.24 001007432.2_16124001_2 - 3.9e-12 46.1 1.5 8.4e-12 45.0 1.5 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.11 001007432.2_16124001_2 - 1.9e-11 44.0 0.3 2.3e-10 40.6 0.0 2.4 2 0 0 2 2 2 1 GHMP kinases C terminal UQ_con PF00179.24 200921.3_16124001_1 - 6.9e-46 155.2 0.0 1e-45 154.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.4 200921.3_16124001_1 - 0.054 13.0 0.0 0.087 12.4 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B UDPGT PF00201.16 001037428.2_16124001_2 - 8e-202 671.3 0.0 9.7e-202 671.0 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001037428.2_16124001_2 - 2.1e-07 30.9 0.0 4.3e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Solute_trans_a PF03619.14 001017718.2_16128001_3 - 1.3e-92 310.0 20.5 2e-92 309.4 20.5 1.3 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DUF2207 PF09972.7 001077153.2_16128001_1 - 0.33 9.5 1.1 0.52 8.9 1.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) MMPL PF03176.13 001077153.2_16128001_1 - 6.6 5.4 5.0 9.5 4.9 5.0 1.1 1 0 0 1 1 1 0 MMPL family Tis11B_N PF04553.10 001077153.2_16128001_2 - 8.6e-37 126.1 0.1 1.7e-36 125.1 0.1 1.5 1 0 0 1 1 1 1 Tis11B like protein, N terminus zf-CCCH PF00642.22 001077153.2_16128001_2 - 1.1e-21 76.0 14.8 4.4e-11 42.3 2.0 2.8 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 001077153.2_16128001_2 - 0.17 12.2 21.6 0.31 11.5 1.4 4.2 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger Torus PF16131.3 001077153.2_16128001_2 - 0.2 12.2 9.2 2.8 8.5 0.9 2.6 1 1 1 2 2 2 0 Torus domain WSK PF03832.11 001098184.2_16129001_2 - 1.7e-23 81.8 25.8 2.8e-11 42.8 1.4 5.1 4 0 0 4 4 4 3 WSK motif Cmc1 PF08583.8 001164348.2_23522001_3 - 1.5e-15 56.8 5.2 1.6e-15 56.7 4.0 1.6 2 0 0 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like DUF755 PF05501.9 001164348.2_23522001_3 - 0.29 11.3 1.4 0.39 10.9 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Cystatin PF00031.19 133011.1_16122120_2 - 9.7e-17 60.9 0.7 1.5e-16 60.3 0.7 1.3 1 0 0 1 1 1 1 Cystatin domain Dynein_light PF01221.16 133011.1_16122120_2 - 0.00097 19.3 0.1 0.0016 18.5 0.1 1.4 1 0 0 1 1 1 1 Dynein light chain type 1 Peptidase_M14 PF00246.22 001002217.1_16123001_1 - 4.4e-91 305.6 0.1 5.6e-91 305.2 0.1 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.14 001002217.1_16123001_1 - 7.9e-20 70.9 0.2 1.5e-19 70.0 0.2 1.5 1 0 0 1 1 1 1 Carboxypeptidase activation peptide DUF4604 PF15377.4 001002217.1_16123001_2 - 0.00011 22.6 5.4 0.00013 22.4 5.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) GATase_6 PF13522.4 001004401.1_23526001_1 - 2e-14 53.8 0.0 3.7e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.4 001004401.1_23526001_1 - 1.6e-12 47.3 0.0 2.7e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.25 001004401.1_23526001_1 - 5e-08 32.5 0.0 7.9e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.4 001004401.1_23526001_1 - 2.9e-06 26.3 0.0 4.3e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_2 PF00310.19 001004401.1_23526001_1 - 0.014 14.0 0.0 0.023 13.3 0.0 1.3 1 0 0 1 1 1 0 Glutamine amidotransferases class-II GTP_EFTU PF00009.25 205368.1_23527001_1 - 7.1e-65 218.1 0.0 9.7e-65 217.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.16 205368.1_23527001_1 - 6.9e-35 119.3 0.0 2.6e-34 117.5 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.22 205368.1_23527001_1 - 1e-22 79.8 0.0 2.3e-22 78.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.4 205368.1_23527001_1 - 2.3e-13 49.9 0.0 5.2e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.23 205368.1_23527001_1 - 2.9e-13 49.9 0.2 1.6e-12 47.5 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 205368.1_23527001_1 - 1.4e-05 25.0 0.1 3.3e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Collagen PF01391.16 204426.1_23529001_3 - 1.8e-177 575.2 727.8 5.2e-10 38.8 29.8 22.2 2 2 18 20 20 20 17 Collagen triple helix repeat (20 copies) COLFI PF01410.16 204426.1_23529001_3 - 5.6e-112 372.6 0.3 7.6e-112 372.1 0.3 1.2 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain DUF4083 PF13314.4 204426.1_23529001_3 - 0.2 11.5 0.0 0.32 10.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Mre11_DNA_bind PF04152.12 204778.1_23525001_1 - 1.9e-45 155.1 2.1 1.9e-45 155.1 2.1 2.1 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.26 204778.1_23525001_1 - 7.1e-14 52.6 0.8 1.4e-13 51.7 0.8 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.5 204778.1_23525001_1 - 4.8e-05 23.5 0.0 0.00049 20.2 0.0 2.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain FAM25 PF15825.3 204778.1_23525001_1 - 0.4 10.9 2.2 1 9.6 1.8 2.0 1 1 0 1 1 1 0 FAM25 family APG6 PF04111.10 204778.1_23525001_1 - 0.71 9.1 10.3 1.4 8.1 10.3 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Histone_H2A_C PF16211.3 001281481.1_23521001_1 - 1.4e-20 72.6 1.1 2.6e-20 71.7 1.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.22 001281481.1_23521001_1 - 6.1e-17 62.1 0.0 8.2e-17 61.7 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 001281481.1_23521001_1 - 4.2e-05 23.6 0.0 5.8e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SH3_2 PF07653.15 001353939.1_23524001_3 - 1.3e-24 85.5 0.8 1.3e-11 43.8 0.0 3.3 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.26 001353939.1_23524001_3 - 1.5e-19 69.2 0.9 6.2e-16 57.6 0.4 2.6 2 0 0 2 2 2 2 SH3 domain SH2 PF00017.22 001353939.1_23524001_3 - 9.1e-17 60.8 0.0 1.8e-16 59.8 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_9 PF14604.4 001353939.1_23524001_3 - 6e-14 51.5 0.1 1.3e-09 37.6 0.1 2.8 3 0 0 3 3 3 2 Variant SH3 domain BLM10_mid PF16507.3 001191020.1_16129001_1 - 1.3e-112 377.1 0.1 4e-111 372.1 0.2 3.0 2 1 0 2 2 2 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.6 001191020.1_16129001_1 - 7e-36 121.9 0.0 7.7e-35 118.6 0.0 3.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) HEAT PF02985.20 001191020.1_16129001_1 - 5.6e-05 22.9 1.8 0.18 12.0 0.1 4.9 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.4 001191020.1_16129001_1 - 0.024 14.9 0.1 1.7 8.9 0.0 3.9 4 1 1 5 5 5 0 HEAT repeats UME PF08064.11 001191020.1_16129001_1 - 0.065 13.0 0.2 0.75 9.6 0.0 2.9 2 0 0 2 2 2 0 UME (NUC010) domain Ion_trans PF00520.29 001128239.1_16128001_1 - 3.7e-13 49.1 17.2 1.2e-12 47.5 17.2 1.8 1 1 0 1 1 1 1 Ion transport protein SesA PF17107.3 001128239.1_16128001_1 - 0.085 12.9 0.1 0.24 11.5 0.1 1.7 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Collagen PF01391.16 001122840.1_16129001_2 - 1.1e-20 73.0 87.3 1.4e-08 34.2 31.5 3.2 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) Lectin_C PF00059.19 001122840.1_16129001_2 - 1.7e-10 41.4 0.4 6.6e-10 39.6 0.4 2.1 1 0 0 1 1 1 1 Lectin C-type domain Filament PF00038.19 001122840.1_16129001_2 - 0.075 12.5 30.5 0.0046 16.4 23.6 2.1 1 1 1 2 2 2 0 Intermediate filament protein DUF3206 PF11472.6 001122840.1_16129001_2 - 0.079 12.8 0.3 0.19 11.6 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3206) DUF3584 PF12128.6 001122840.1_16129001_2 - 0.61 7.4 33.5 1.2 6.4 25.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) KASH_CCD PF14662.4 001122840.1_16129001_2 - 0.95 9.1 29.9 0.73 9.5 10.0 3.1 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.9 001122840.1_16129001_2 - 2 7.1 32.1 0.26 10.0 11.4 3.3 1 1 0 3 3 3 0 Spc7 kinetochore protein Alpha-2-MRAP_C PF06401.9 001122840.1_16129001_2 - 2.9 7.7 20.0 0.033 14.0 9.7 2.5 1 1 0 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain IncA PF04156.12 001122840.1_16129001_2 - 3.3 7.3 31.7 2.7e+03 -2.2 8.3 3.4 1 1 1 2 2 2 0 IncA protein Collagen_mid PF15984.3 001122840.1_16129001_2 - 9.4 5.8 7.4 1.8 8.2 1.8 2.3 2 1 1 3 3 3 0 Bacterial collagen, middle region DUF4665 PF15679.3 001122840.1_16129001_2 - 9.7 6.8 7.3 3 8.4 0.5 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4665) DDE_3 PF13358.4 001122840.1_16129001_3 - 0.00014 21.5 0.2 0.00022 20.9 0.2 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease adh_short PF00106.23 001031022.1_23526001_2 - 5.1e-47 159.7 0.2 6.7e-47 159.3 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001031022.1_23526001_2 - 1e-31 110.2 0.0 1.4e-31 109.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001031022.1_23526001_2 - 6.4e-09 35.8 0.3 9.4e-09 35.3 0.3 1.2 1 0 0 1 1 1 1 KR domain Methyltransf_10 PF05971.10 001003611.1_16124001_3 - 1.6e-124 415.0 0.0 2.1e-124 414.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF890) MTS PF05175.12 001003611.1_16124001_3 - 0.00095 18.6 0.0 0.0017 17.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.11 001003611.1_16124001_3 - 0.0023 17.2 0.0 0.0038 16.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PAD PF03068.13 205043.1_23525001_1 - 4.1e-170 565.8 0.0 5e-170 565.5 0.0 1.1 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) PAD_M PF08527.8 205043.1_23525001_1 - 2.3e-64 215.7 0.0 4.5e-64 214.8 0.0 1.5 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) middle domain PAD_N PF08526.8 205043.1_23525001_1 - 9.5e-38 128.9 0.1 1.6e-37 128.2 0.1 1.4 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) N-terminal domain Homeobox PF00046.27 001017625.2_16123001_2 - 3.1e-22 78.0 2.4 3.1e-22 78.0 2.4 2.3 1 1 1 2 2 2 1 Homeobox domain OAR PF03826.15 001017625.2_16123001_2 - 1.1e-05 24.9 1.2 2.5e-05 23.8 1.2 1.6 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 001017625.2_16123001_2 - 0.015 15.0 0.1 0.038 13.8 0.1 1.7 1 0 0 1 1 1 0 Homeobox KN domain HA PF03457.12 001017625.2_16123001_2 - 9.1 6.6 8.2 4.7 7.5 4.9 2.1 1 1 1 2 2 2 0 Helicase associated domain LIM PF00412.20 001040010.3_16128001_3 - 2.3e-30 104.5 21.5 4.5e-15 55.5 10.1 2.4 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 001040010.3_16128001_3 - 1.7e-18 66.0 3.4 3e-18 65.2 3.4 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001040010.3_16128001_3 - 5.1e-05 23.0 0.4 0.00018 21.2 0.2 2.0 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.6 001040010.3_16128001_3 - 0.026 13.9 0.0 0.059 12.7 0.0 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez HLH PF00010.24 131551.2_16122001_2 - 7.4e-14 51.3 0.2 1.1e-13 50.7 0.2 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hormone_1 PF00103.18 204359.2_23522001_1 - 3.7e-43 147.6 0.0 4.3e-43 147.4 0.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family Lipoxygenase PF00305.17 001020578.1_16126001_1 - 1.7e-84 284.4 0.8 5.7e-84 282.7 0.9 1.6 1 1 1 2 2 2 1 Lipoxygenase PLAT PF01477.21 001020578.1_16126001_1 - 1.8e-20 73.5 0.0 4.2e-20 72.3 0.0 1.7 1 0 0 1 1 1 1 PLAT/LH2 domain PQQ_2 PF13360.4 001020530.1_16123001_1 - 2.3e-07 30.5 0.1 0.013 15.0 0.0 2.2 2 0 0 2 2 2 2 PQQ-like domain PQQ PF01011.19 001020530.1_16123001_1 - 2.8e-05 23.7 0.7 0.21 11.4 0.0 3.7 4 0 0 4 4 4 2 PQQ enzyme repeat PQQ_3 PF13570.4 001020530.1_16123001_1 - 0.015 15.6 1.4 5.5 7.5 0.0 4.7 4 2 1 5 5 5 0 PQQ-like domain PIP5K PF01504.16 001128702.1_16123001_3 - 1.1e-75 254.3 1.4 1.5e-75 253.8 1.4 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Calcipressin PF04847.10 001003616.1_16124001_1 - 2.2e-52 177.4 0.0 3e-52 176.9 0.0 1.1 1 0 0 1 1 1 1 Calcipressin PAP2 PF01569.19 001079978.1_16124001_3 - 6.6e-26 90.6 3.3 1.2e-25 89.7 3.3 1.4 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.4 001079978.1_16124001_3 - 0.00033 21.0 2.0 0.0011 19.3 2.0 1.9 1 0 0 1 1 1 1 PAP2 superfamily C-terminal Plexin_cytopl PF08337.10 001110010.1_16129001_1 - 4.3e-257 854.1 4.7 5.4e-257 853.8 4.7 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.17 001110010.1_16129001_1 - 3.6e-75 253.2 0.0 5.5e-75 252.6 0.0 1.3 1 0 0 1 1 1 1 Sema domain TIG PF01833.22 001110010.1_16129001_1 - 5.3e-44 148.1 9.5 4.4e-11 42.6 0.2 5.6 5 0 0 5 5 5 4 IPT/TIG domain PSI PF01437.23 001110010.1_16129001_1 - 3.8e-21 75.2 56.8 1.3e-10 41.5 13.9 3.7 3 0 0 3 3 3 3 Plexin repeat LRR_9 PF14580.4 001020701.2_16124001_1 - 5.9e-12 45.3 2.8 1.4e-11 44.1 2.8 1.5 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.5 001020701.2_16124001_1 - 6.7e-07 29.4 12.7 0.00082 19.6 5.4 3.5 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) F1F0-ATPsyn_F PF10791.7 001020701.2_16124001_1 - 0.015 15.6 0.0 0.027 14.8 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial F1-F0 ATP synthase subunit F of fungi LRR_8 PF13855.4 001020701.2_16124001_1 - 0.018 14.7 8.3 1.1 9.0 0.8 2.8 2 0 0 2 2 2 0 Leucine rich repeat Cluap1 PF10234.7 213008.1_16124001_3 - 1.4e-116 388.4 11.5 2e-116 387.9 11.5 1.2 1 0 0 1 1 1 1 Clusterin-associated protein-1 TFIIA PF03153.11 213008.1_16124001_3 - 0.064 13.1 16.8 0.083 12.7 16.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Exonuc_VII_L PF02601.13 213008.1_16124001_3 - 0.27 10.6 9.3 0.43 10.0 9.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Nop14 PF04147.10 213008.1_16124001_3 - 2.1 6.3 34.3 1 7.3 0.7 2.1 2 0 0 2 2 2 0 Nop14-like family Alb1 PF09135.9 213008.1_16124001_3 - 6.4 7.7 11.0 1.1e+02 3.6 11.0 2.3 1 1 0 1 1 1 0 Alb1 Pkinase_Tyr PF07714.15 001256664.1_16127001_1 - 2e-95 318.9 0.0 2.7e-95 318.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001256664.1_16127001_1 - 3.4e-45 154.3 0.0 4.9e-45 153.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TPKR_C2 PF16920.3 001256664.1_16127001_1 - 2.4e-20 72.3 8.3 7e-20 70.8 7.4 2.4 2 0 0 2 2 2 1 Tyrosine-protein kinase receptor C2 Ig-like domain Ig_3 PF13927.4 001256664.1_16127001_1 - 4.6e-18 65.5 0.7 2.8e-11 43.7 0.2 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001256664.1_16127001_1 - 2.7e-16 59.3 0.0 8.8e-10 38.4 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 001256664.1_16127001_1 - 1.7e-13 50.4 0.1 1.8e-09 37.5 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001256664.1_16127001_1 - 6.3e-12 45.5 0.4 5.6e-07 29.7 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain LRR_8 PF13855.4 001256664.1_16127001_1 - 1.6e-10 40.5 3.4 3.9e-10 39.2 2.9 2.0 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.5 001256664.1_16127001_1 - 0.00012 22.2 2.9 0.00012 22.2 2.9 2.4 2 0 0 2 2 1 1 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001256664.1_16127001_1 - 0.00014 21.7 0.2 0.00043 20.1 0.2 1.8 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) C2-set_2 PF08205.10 001256664.1_16127001_1 - 0.0007 19.5 0.0 0.027 14.4 0.0 2.5 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain LRR_1 PF00560.31 001256664.1_16127001_1 - 0.0054 16.9 6.3 0.86 10.2 0.5 4.4 3 0 0 3 3 3 2 Leucine Rich Repeat LRRNT PF01462.16 001256664.1_16127001_1 - 0.59 9.7 4.0 1.7 8.2 4.0 1.9 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain LRR_6 PF13516.4 001256664.1_16127001_1 - 8.8 6.5 5.8 1.1 9.3 0.1 2.6 3 0 0 3 3 2 0 Leucine Rich repeat CARD_2 PF16739.3 001193638.1_23528001_2 - 2.4e-41 139.5 0.1 2.1e-19 69.2 0.0 2.7 2 0 0 2 2 2 2 Caspase recruitment domain RIG-I_C-RD PF11648.6 001193638.1_23528001_2 - 1.8e-38 131.3 3.5 6.4e-38 129.5 3.5 2.1 1 0 0 1 1 1 1 C-terminal domain of RIG-I ResIII PF04851.13 001193638.1_23528001_2 - 1.3e-20 73.9 0.2 5.3e-20 72.0 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.29 001193638.1_23528001_2 - 3e-19 69.3 2.0 2.9e-18 66.1 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.27 001193638.1_23528001_2 - 3.8e-18 65.7 2.0 6.8e-18 64.9 0.0 2.6 3 0 0 3 3 3 1 DEAD/DEAH box helicase CARD PF00619.19 001193638.1_23528001_2 - 1.6e-08 34.4 0.2 2.4e-05 24.1 0.3 2.7 2 0 0 2 2 2 2 Caspase recruitment domain SNF2_N PF00176.21 001193638.1_23528001_2 - 0.0012 17.5 1.0 0.0027 16.3 0.1 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain AAA_19 PF13245.4 001193638.1_23528001_2 - 0.0075 16.5 0.0 0.38 11.0 0.1 3.0 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.4 001193638.1_23528001_2 - 0.01 15.9 0.4 0.11 12.6 0.0 2.7 2 1 0 2 2 2 0 AAA domain DUF3638 PF12340.6 001193638.1_23528001_2 - 0.04 13.1 0.0 0.087 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) DUF2757 PF10955.6 001193638.1_23528001_2 - 0.046 13.9 3.0 0.21 11.8 3.0 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) Rpr2 PF04032.14 001193638.1_23528001_2 - 0.38 11.0 3.3 1.5 9.1 3.3 2.1 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain AAA_11 PF13086.4 001193638.1_23528001_2 - 2.7 7.5 19.7 0.19 11.3 0.2 4.5 3 1 0 4 4 4 0 AAA domain zf-H2C2_2 PF13465.4 001318466.1_23529001_1 - 4.7e-32 108.9 61.2 8.1e-08 32.3 5.1 8.7 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.24 001318466.1_23529001_1 - 2.2e-24 84.3 72.9 0.00013 22.1 5.0 8.7 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001318466.1_23529001_1 - 1.5e-15 56.4 69.7 0.0055 17.3 1.2 8.9 8 0 0 8 8 8 7 C2H2-type zinc finger zf-Di19 PF05605.10 001318466.1_23529001_1 - 2.6e-08 33.9 1.9 2.6e-08 33.9 1.9 4.3 4 0 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 001318466.1_23529001_1 - 3.9e-07 30.1 55.4 0.013 15.7 1.7 8.9 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001318466.1_23529001_1 - 9.9e-06 25.6 58.4 0.17 12.2 3.5 8.7 8 0 0 8 8 8 4 Zinc-finger of C2H2 type Homeobox PF00046.27 001318466.1_23529001_1 - 6.4e-05 22.6 0.0 0.00041 20.0 0.0 2.4 2 0 0 2 2 2 1 Homeobox domain zf-H2C2_5 PF13909.4 001318466.1_23529001_1 - 0.00066 19.2 0.5 0.00066 19.2 0.5 5.8 6 1 0 6 6 4 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.4 001318466.1_23529001_1 - 0.0015 18.3 65.9 0.028 14.2 1.4 8.6 8 0 0 8 8 8 5 C2H2-type zinc finger zf-C2H2_2 PF12756.5 001318466.1_23529001_1 - 0.019 15.2 0.6 0.019 15.2 0.6 7.0 4 3 3 7 7 7 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_15 PF17032.3 001318466.1_23529001_1 - 4.6 7.9 29.1 0.36 11.5 1.5 5.3 4 1 1 5 5 5 0 zinc-ribbon family zf-C2HC_2 PF13913.4 001318466.1_23529001_1 - 9.3 6.1 34.4 8.4 6.3 0.1 7.5 7 0 0 7 7 7 0 zinc-finger of a C2HC-type JmjC PF02373.20 001030178.2_16129001_1 - 4.7e-31 107.5 2.0 1.9e-30 105.5 2.0 2.2 1 0 0 1 1 1 1 JmjC domain, hydroxylase Pkinase PF00069.23 205055.1_23525001_1 - 3.1e-78 262.7 0.0 4.1e-78 262.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 205055.1_23525001_1 - 2.5e-35 121.9 0.0 3.6e-35 121.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.27 205055.1_23525001_1 - 1.5e-16 60.6 0.2 3.1e-16 59.7 0.2 1.5 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.22 205055.1_23525001_1 - 2.9e-10 40.5 3.3 7.8e-10 39.2 3.3 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 205055.1_23525001_1 - 3.1e-08 33.1 0.0 1.7e-07 30.7 0.0 1.9 2 0 0 2 2 2 1 Kinase-like PH_11 PF15413.4 205055.1_23525001_1 - 0.019 15.3 0.6 0.049 13.9 0.1 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain Seadorna_VP7 PF07387.9 205055.1_23525001_1 - 0.076 11.9 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Spot_14 PF07084.10 213439.1_16123001_2 - 1e-59 200.9 0.6 1.3e-59 200.5 0.6 1.1 1 0 0 1 1 1 1 Thyroid hormone-inducible hepatic protein Spot 14 PI3Ka PF00613.18 001004410.1_23527001_1 - 1e-69 233.5 1.9 1.9e-69 232.6 1.9 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.25 001004410.1_23527001_1 - 5.2e-58 196.7 1.4 2.9e-57 194.2 1.4 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_rbd PF00794.16 001004410.1_23527001_1 - 2.7e-39 133.5 1.0 1.8e-37 127.6 0.5 2.8 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.22 001004410.1_23527001_1 - 2.3e-32 111.7 0.0 5.5e-32 110.5 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_p85B PF02192.14 001004410.1_23527001_1 - 7.5e-31 105.5 0.4 1.9e-30 104.3 0.4 1.7 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain DUF2321 PF10083.7 001004410.1_23527001_1 - 0.019 14.5 0.0 0.043 13.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) DUF4135 PF13575.4 001004410.1_23527001_1 - 0.067 12.4 0.0 0.16 11.1 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4135) Lectin_C PF00059.19 131570.2_16123001_1 - 7.3e-17 61.9 0.0 1e-16 61.5 0.0 1.2 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 131570.2_16123001_1 - 8e-09 35.0 32.5 1.6e-07 30.9 32.5 2.1 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) SET PF00856.26 001045349.2_16124001_1 - 5.9e-19 68.9 0.5 5.2e-18 65.9 0.0 2.4 2 1 0 2 2 2 1 SET domain ASFV_L11L PF05293.9 001045349.2_16124001_3 - 0.14 12.3 3.7 0.23 11.7 3.7 1.2 1 0 0 1 1 1 0 African swine fever virus (ASFV) L11L protein PrmA PF06325.11 001161495.1_16122001_2 - 1.9e-11 43.8 0.1 2.5e-11 43.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.7 001161495.1_16122001_2 - 3.1e-09 36.7 0.0 8.2e-09 35.3 0.0 1.6 1 1 0 1 1 1 1 Lysine methyltransferase MTS PF05175.12 001161495.1_16122001_2 - 2.7e-06 26.9 0.0 6.3e-06 25.7 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain Met_10 PF02475.14 001161495.1_16122001_2 - 0.0004 20.0 0.0 0.00066 19.3 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_25 PF13649.4 001161495.1_16122001_2 - 0.005 17.4 0.1 0.01 16.4 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.17 001161495.1_16122001_2 - 0.0055 16.3 0.0 0.0083 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.4 001161495.1_16122001_2 - 0.023 14.5 0.0 0.035 13.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DNA_methylase PF00145.15 001161495.1_16122001_2 - 0.026 13.8 0.0 0.038 13.2 0.0 1.2 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase TehB PF03848.12 001161495.1_16122001_2 - 0.039 13.2 0.0 0.06 12.6 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Peptidase_M76 PF09768.7 001083580.1_16123001_3 - 1.3e-56 190.9 5.4 1.8e-56 190.4 5.4 1.2 1 0 0 1 1 1 1 Peptidase M76 family Peptidase_M90 PF06167.10 001083580.1_16123001_3 - 0.051 13.0 0.1 0.081 12.4 0.1 1.2 1 0 0 1 1 1 0 Glucose-regulated metallo-peptidase M90 RRM_1 PF00076.20 001308615.1_16125001_2 - 7.3e-60 198.6 0.0 2.6e-19 68.7 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001308615.1_16125001_2 - 6e-14 51.6 0.0 1.7e-05 24.3 0.0 3.2 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 001308615.1_16125001_2 - 0.00053 19.9 0.0 0.11 12.4 0.0 2.4 2 0 0 2 2 2 2 RNA binding motif RRM_occluded PF16842.3 001308615.1_16125001_2 - 0.0012 18.5 0.0 4.2 7.2 0.0 3.3 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_7 PF16367.3 001308615.1_16125001_2 - 0.055 13.5 0.0 2.2 8.4 0.0 2.9 3 0 0 3 3 3 0 RNA recognition motif PHM7_cyt PF14703.4 001308615.1_16125001_2 - 0.061 13.4 0.2 11 6.1 0.0 3.6 3 2 2 5 5 5 0 Cytosolic domain of 10TM putative phosphate transporter SET PF00856.26 001100089.1_16124001_2 - 3.5e-15 56.6 0.1 3.5e-15 56.6 0.1 2.5 2 2 0 2 2 2 1 SET domain DUF966 PF06136.11 001100089.1_16124001_2 - 0.14 11.7 12.4 0.2 11.2 12.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Methyltransf_31 PF13847.4 001013327.1_16122001_3 - 7e-18 64.7 0.0 9.2e-18 64.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 001013327.1_16122001_3 - 3.8e-12 46.6 0.0 8.5e-12 45.5 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001013327.1_16122001_3 - 2.7e-09 37.4 0.0 4.2e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001013327.1_16122001_3 - 5.1e-08 33.4 0.0 7.6e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001013327.1_16122001_3 - 1.8e-06 27.8 0.0 3.1e-06 27.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 001013327.1_16122001_3 - 6.5e-05 22.4 0.0 0.0001 21.7 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.18 001013327.1_16122001_3 - 0.00022 20.5 0.0 0.0003 20.1 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.15 001013327.1_16122001_3 - 0.00039 19.8 0.0 0.00061 19.2 0.0 1.4 1 1 0 1 1 1 1 Putative methyltransferase PrmA PF06325.11 001013327.1_16122001_3 - 0.0013 18.1 0.0 0.0018 17.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TehB PF03848.12 001013327.1_16122001_3 - 0.007 15.7 0.1 0.012 14.9 0.1 1.4 1 1 1 2 2 2 1 Tellurite resistance protein TehB MetW PF07021.10 001013327.1_16122001_3 - 0.012 15.1 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.5 001013327.1_16122001_3 - 0.014 15.2 0.0 0.03 14.1 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_24 PF13578.4 001013327.1_16122001_3 - 0.022 15.6 0.0 0.032 15.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.17 001013327.1_16122001_3 - 0.023 14.3 0.0 0.031 13.9 0.0 1.1 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Spermine_synth PF01564.15 001013327.1_16122001_3 - 0.036 12.9 0.0 0.054 12.3 0.0 1.2 1 0 0 1 1 1 0 Spermine/spermidine synthase RrnaAD PF00398.18 001013327.1_16122001_3 - 0.054 12.4 0.0 0.069 12.1 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase AdoMet_MTase PF07757.11 001013327.1_16122001_3 - 0.067 13.4 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Hep_core_N PF08290.9 001098488.1_16129001_1 - 0.28 11.1 5.4 0.49 10.3 2.4 3.2 2 0 0 2 2 2 0 Hepatitis core protein, putative zinc finger Spectrin PF00435.19 001098488.1_16129001_3 - 0 1533.5 246.2 3.6e-30 104.4 3.4 23.3 23 0 0 23 23 23 22 Spectrin repeat EFhand_Ca_insen PF08726.8 001098488.1_16129001_3 - 6e-28 96.6 1.2 2.8e-26 91.2 0.2 3.6 3 0 0 3 3 2 1 Ca2+ insensitive EF hand SH3_1 PF00018.26 001098488.1_16129001_3 - 4.2e-15 54.9 0.0 9.3e-15 53.8 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001098488.1_16129001_3 - 2.3e-12 46.4 0.0 1.3e-10 40.8 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain EF-hand_1 PF00036.30 001098488.1_16129001_3 - 1.3e-11 43.1 0.4 9.4e-06 24.7 0.1 3.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 001098488.1_16129001_3 - 3.2e-10 40.2 0.3 1.8e-08 34.6 0.1 4.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.4 001098488.1_16129001_3 - 1.9e-08 33.5 0.3 0.00057 19.5 0.1 4.9 4 0 0 4 4 4 1 EF-hand domain EF-hand_8 PF13833.4 001098488.1_16129001_3 - 1.6e-07 30.9 0.0 0.044 13.4 0.1 3.6 3 0 0 3 3 3 2 EF-hand domain pair SH3_2 PF07653.15 001098488.1_16129001_3 - 3.7e-07 29.6 0.0 1.7e-06 27.5 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain GvpG PF05120.10 001098488.1_16129001_3 - 5.2e-05 23.1 5.9 1.8 8.5 0.1 5.3 3 0 0 3 3 3 2 Gas vesicle protein G SH3_3 PF08239.9 001098488.1_16129001_3 - 0.00033 20.7 0.0 0.0014 18.8 0.0 2.2 1 0 0 1 1 1 1 Bacterial SH3 domain EF-hand_5 PF13202.4 001098488.1_16129001_3 - 0.0011 18.2 0.0 2.2 7.8 0.0 3.3 2 0 0 2 2 2 2 EF hand Peroxidase_2 PF01328.15 001098488.1_16129001_3 - 0.2 10.7 0.2 1.4 7.8 0.1 2.2 2 0 0 2 2 2 0 Peroxidase, family 2 DUF3477 PF11963.6 001098488.1_16129001_3 - 8.3 5.4 8.0 3.4 6.7 0.1 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3477) Raftlin PF15250.4 199552.1_16123001_2 - 1.6 7.2 11.9 2.4 6.7 11.9 1.1 1 0 0 1 1 1 0 Raftlin Zip PF02535.20 199552.1_16123001_2 - 1.6 7.7 4.9 2.6 7.1 4.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Linker_histone PF00538.17 199552.1_16123001_3 - 4.3e-25 87.7 0.5 4.3e-25 87.7 0.5 2.2 2 0 0 2 2 2 1 linker histone H1 and H5 family F-actin_cap_A PF01267.15 205515.1_23525001_3 - 2e-106 355.2 0.7 2.5e-106 354.9 0.7 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit CCP_MauG PF03150.12 205515.1_23525001_3 - 0.12 12.9 0.1 0.72 10.4 0.1 2.0 1 1 0 1 1 1 0 Di-haem cytochrome c peroxidase BORG_CEP PF14957.4 001004568.2_16124001_2 - 3.4e-25 89.3 2.8 9.4e-25 87.9 2.8 1.7 1 1 0 1 1 1 1 Cdc42 effector PBD PF00786.26 001004568.2_16124001_2 - 1.3e-06 28.6 0.0 2.9e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain PDZ PF00595.22 214728.1_16126001_2 - 1.5e-65 217.4 7.4 8e-21 74.1 0.5 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) Guanylate_kin PF00625.19 214728.1_16126001_2 - 1.1e-63 214.0 0.2 1.8e-63 213.4 0.2 1.3 1 0 0 1 1 1 1 Guanylate kinase L27_1 PF09058.8 214728.1_16126001_2 - 4.1e-21 74.7 1.2 1.2e-20 73.2 1.2 1.8 1 0 0 1 1 1 1 L27_1 PDZ_2 PF13180.4 214728.1_16126001_2 - 1.3e-16 60.6 0.6 7.4e-05 22.8 0.0 3.4 3 0 0 3 3 3 3 PDZ domain PDZ_assoc PF10600.7 214728.1_16126001_2 - 2.7e-15 56.8 6.7 1.1e-14 54.9 6.7 2.2 1 0 0 1 1 1 1 PDZ-associated domain of NMDA receptors MAGUK_N_PEST PF10608.7 214728.1_16126001_2 - 1.9e-08 34.7 0.8 2.5e-07 31.1 0.1 2.4 1 1 1 2 2 2 1 Polyubiquitination (PEST) N-terminal domain of MAGUK SH3_1 PF00018.26 214728.1_16126001_2 - 7.3e-06 25.4 0.1 1.9e-05 24.0 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 214728.1_16126001_2 - 0.013 15.2 0.1 0.034 13.9 0.1 1.8 1 0 0 1 1 1 0 Variant SH3 domain L27_2 PF09045.8 214728.1_16126001_2 - 0.16 11.8 1.0 0.45 10.4 0.1 2.3 2 0 0 2 2 2 0 L27_2 DUF2502 PF10697.7 214728.1_16126001_2 - 0.16 12.2 0.2 0.44 10.8 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2502) APG6 PF04111.10 001006332.1_23524001_1 - 9.1e-129 429.2 11.8 1.1e-128 428.9 11.8 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 BH3 PF15285.4 001006332.1_23524001_1 - 6.2e-17 60.8 0.2 1.1e-16 60.0 0.2 1.4 1 0 0 1 1 1 1 Beclin-1 BH3 domain, Bcl-2-interacting DUF342 PF03961.11 001006332.1_23524001_1 - 0.0058 15.2 10.9 0.0094 14.5 10.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF342) Exonuc_VII_L PF02601.13 001006332.1_23524001_1 - 0.43 10.0 6.0 0.64 9.4 6.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit MT PF12777.5 001006332.1_23524001_1 - 0.69 8.7 8.8 1.2 8.0 8.8 1.2 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor ERM PF00769.17 001006332.1_23524001_1 - 1.1 9.0 22.5 2 8.0 22.5 1.4 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Jnk-SapK_ap_N PF09744.7 001006332.1_23524001_1 - 3 7.9 22.4 5.5 7.1 22.4 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 NUDE_C PF04880.11 001006169.1_23524001_3 - 1.9e-43 148.9 4.7 1.9e-43 148.9 4.7 2.3 2 0 0 2 2 2 1 NUDE protein, C-terminal conserved region DMPK_coil PF08826.8 001006169.1_23524001_3 - 0.0035 17.3 6.5 0.0035 17.3 6.5 3.6 2 1 1 3 3 3 1 DMPK coiled coil domain like PRKG1_interact PF15898.3 001006169.1_23524001_3 - 0.025 15.4 10.9 0.025 15.4 10.9 3.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF972 PF06156.11 001006169.1_23524001_3 - 0.2 12.1 22.7 3.9 8.0 0.3 3.5 1 1 2 3 3 3 0 Protein of unknown function (DUF972) ATG16 PF08614.9 001006169.1_23524001_3 - 0.52 10.3 36.3 0.68 10.0 21.3 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Lectin_N PF03954.12 001006169.1_23524001_3 - 1.3 8.6 8.1 0.2 11.2 2.2 2.4 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain FPP PF05911.9 001006169.1_23524001_3 - 1.8 6.6 28.2 0.89 7.6 17.0 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil DUF1515 PF07439.9 001006169.1_23524001_3 - 1.8 8.5 7.9 1.9 8.4 2.5 3.1 2 1 2 4 4 4 0 Protein of unknown function (DUF1515) HIP1_clath_bdg PF16515.3 001006169.1_23524001_3 - 2.2 8.8 27.6 0.034 14.6 10.4 2.7 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF148 PF02520.15 001006169.1_23524001_3 - 2.5 8.1 14.1 0.1 12.6 4.2 2.5 1 1 2 3 3 3 0 Domain of unknown function DUF148 TPR_MLP1_2 PF07926.10 001006169.1_23524001_3 - 2.6 8.0 37.1 1.5 8.8 9.4 3.4 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Rootletin PF15035.4 001006169.1_23524001_3 - 7.2 6.5 35.8 2.9 7.8 14.6 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion ADIP PF11559.6 001006169.1_23524001_3 - 9.1 6.2 28.4 1 9.3 4.5 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Cyclin_N PF00134.21 199740.1_16124001_1 - 6.5e-15 54.9 0.1 1.1e-09 38.1 0.0 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.17 199740.1_16124001_1 - 2.6e-07 30.6 0.2 8.5e-07 28.9 0.1 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain TFIIB PF00382.17 199740.1_16124001_1 - 0.01 15.7 0.4 1.2 9.1 0.1 2.5 2 0 0 2 2 2 0 Transcription factor TFIIB repeat Cyclin_C_2 PF16899.3 199740.1_16124001_1 - 0.037 14.3 0.0 0.082 13.2 0.0 1.6 1 0 0 1 1 1 0 Cyclin C-terminal domain Ndc1_Nup PF09531.8 199740.1_16124001_1 - 1.1 7.8 7.2 1.4 7.3 7.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Ras PF00071.20 205048.1_23525001_2 - 2.8e-52 176.5 0.0 3.5e-52 176.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 205048.1_23525001_2 - 1.2e-18 67.4 0.0 1.7e-18 66.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 205048.1_23525001_2 - 4.8e-07 29.3 0.0 7e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PET117 PF15786.3 205048.1_23525001_2 - 0.0022 18.1 0.0 0.0036 17.4 0.0 1.3 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial GTP_EFTU PF00009.25 205048.1_23525001_2 - 0.2 11.0 0.0 0.57 9.5 0.0 1.6 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Pou PF00157.15 204319.1_23527001_1 - 1.7e-33 114.3 3.5 2.5e-33 113.8 0.5 2.6 3 0 0 3 3 3 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 204319.1_23527001_1 - 4e-17 61.6 3.3 4.6e-17 61.5 1.9 1.9 2 0 0 2 2 2 1 Homeobox domain Pkinase_Tyr PF07714.15 205169.1_23527001_1 - 2.1e-90 302.4 0.1 1.9e-53 181.2 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.23 205169.1_23527001_1 - 3.2e-43 147.9 0.0 7.1e-43 146.7 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain I-set PF07679.14 205169.1_23527001_1 - 5e-19 68.0 0.0 1.6e-09 37.6 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain TPKR_C2 PF16920.3 205169.1_23527001_1 - 8.2e-19 67.3 9.2 2.4e-18 65.8 9.2 1.9 1 0 0 1 1 1 1 Tyrosine-protein kinase receptor C2 Ig-like domain Ig_3 PF13927.4 205169.1_23527001_1 - 3.5e-17 62.7 0.5 4.8e-09 36.6 0.6 2.8 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 205169.1_23527001_1 - 1.6e-16 60.1 0.6 1.3e-12 47.6 0.2 2.5 2 0 0 2 2 2 2 Immunoglobulin domain LRR_8 PF13855.4 205169.1_23527001_1 - 2e-12 46.5 2.7 2.7e-12 46.1 0.6 2.2 2 0 0 2 2 2 1 Leucine rich repeat Ig_2 PF13895.4 205169.1_23527001_1 - 8.8e-12 45.1 0.7 1.1e-06 28.8 0.2 2.5 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 205169.1_23527001_1 - 6e-06 26.1 2.1 0.015 15.2 0.1 2.9 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain LRR_4 PF12799.5 205169.1_23527001_1 - 0.00018 21.7 2.8 0.001 19.3 0.4 2.9 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRRNT PF01462.16 205169.1_23527001_1 - 0.00051 19.5 1.9 0.00051 19.5 1.9 2.9 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.4 205169.1_23527001_1 - 0.013 15.3 0.0 0.045 13.6 0.0 1.8 1 1 0 1 1 1 0 Leucine rich repeats (6 copies) LRR_1 PF00560.31 205169.1_23527001_1 - 0.055 13.8 3.4 3.2 8.4 0.2 4.8 4 1 0 4 4 3 0 Leucine Rich Repeat LRR_6 PF13516.4 205169.1_23527001_1 - 0.062 13.3 0.1 0.2 11.7 0.1 1.9 1 0 0 1 1 1 0 Leucine Rich repeat ANF_receptor PF01094.26 001004123.1_16128001_1 - 8e-44 150.0 0.0 1.4e-43 149.3 0.0 1.4 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 001004123.1_16128001_1 - 6.5e-40 136.3 0.1 1.4e-39 135.1 0.1 1.6 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 001004123.1_16128001_1 - 2.7e-35 120.9 0.0 5.5e-35 119.9 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001004123.1_16128001_1 - 4.9e-22 78.3 0.0 7.9e-22 77.7 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Ni_hydr_CYTB PF01292.18 001004123.1_16128001_1 - 0.076 12.5 0.5 4.2 6.8 0.3 2.5 2 0 0 2 2 2 0 Prokaryotic cytochrome b561 Tubulin PF00091.23 205445.1_23527001_2 - 5.1e-70 235.6 0.0 7.5e-70 235.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 205445.1_23527001_2 - 9.1e-40 135.7 0.0 1.6e-39 134.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 205445.1_23527001_2 - 8.8e-05 22.7 0.0 0.00018 21.6 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.4 205445.1_23527001_2 - 0.013 14.5 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 Tubulin like Tubulin_3 PF14881.4 205445.1_23527001_2 - 0.016 14.7 0.0 0.029 13.9 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain Calponin PF00402.16 205516.1_23522001_1 - 3.9e-44 147.8 23.4 9.5e-16 57.0 2.4 3.6 3 0 0 3 3 3 3 Calponin family repeat CH PF00307.29 205516.1_23522001_1 - 5.9e-22 77.8 0.0 9.4e-22 77.1 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 205516.1_23522001_1 - 0.0037 16.9 0.0 0.0071 16.0 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain CDC24 PF06395.9 205516.1_23522001_1 - 0.011 15.9 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 CDC24 Calponin DUF1989 PF09347.8 205516.1_23522001_1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1989) Beta-APP PF03494.11 205516.1_23522001_1 - 0.61 9.9 2.0 12 5.7 0.1 3.0 3 0 0 3 3 3 0 Beta-amyloid peptide (beta-APP) Ribosomal_L5e PF17144.2 204581.4_23522001_1 - 1.3e-94 314.4 0.9 1.3e-94 314.4 0.9 2.1 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.4 204581.4_23522001_1 - 1.4e-38 131.5 11.7 1.4e-38 131.5 11.7 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region DUF1476 PF07345.9 204581.4_23522001_1 - 0.0099 16.1 0.4 0.023 14.9 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1476) Calc_CGRP_IAPP PF00214.17 001002471.1_16123001_1 - 1.6e-40 138.1 0.7 2.7e-40 137.4 0.7 1.4 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family Ribosomal_S17e PF00833.16 204217.1_23521001_2 - 4.2e-70 233.2 0.6 5e-70 233.0 0.6 1.0 1 0 0 1 1 1 1 Ribosomal S17 CK_II_beta PF01214.16 131187.1_16124001_1 - 1e-85 286.0 0.0 1.4e-85 285.7 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit CC2-LZ PF16516.3 001100066.2_16125001_2 - 8.4e-34 115.9 17.5 8.4e-34 115.9 17.5 5.8 2 2 4 6 6 6 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator NEMO PF11577.6 001100066.2_16125001_2 - 4e-28 97.1 14.9 4e-28 97.1 14.9 5.4 5 2 1 6 6 6 1 NF-kappa-B essential modulator NEMO TMF_DNA_bd PF12329.6 001100066.2_16125001_2 - 0.0053 16.6 7.1 0.0053 16.6 7.1 7.2 5 2 1 6 6 5 1 TATA element modulatory factor 1 DNA binding BST2 PF16716.3 001100066.2_16125001_2 - 0.014 15.8 3.2 0.014 15.8 3.2 7.2 3 2 5 8 8 8 0 Bone marrow stromal antigen 2 GM_CSF PF01109.15 001100066.2_16125001_2 - 0.072 13.1 1.8 0.64 10.1 0.0 2.9 2 1 0 2 2 2 0 Granulocyte-macrophage colony-stimulating factor zf-C2H2 PF00096.24 001100066.2_16125001_2 - 0.092 13.1 0.0 0.23 11.8 0.0 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type Pox_A_type_inc PF04508.10 001100066.2_16125001_2 - 0.23 11.2 9.1 9.9 6.1 0.1 5.1 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat GOLGA2L5 PF15070.4 001100066.2_16125001_2 - 0.24 9.9 57.0 0.22 10.0 6.5 2.4 2 0 0 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 ATG16 PF08614.9 001100066.2_16125001_2 - 0.97 9.4 74.1 1 9.4 11.5 4.6 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.7 001100066.2_16125001_2 - 1.1 8.6 72.5 0.54 9.5 15.6 3.9 1 1 3 4 4 4 0 Golgin subfamily A member 5 FlaC_arch PF05377.9 001100066.2_16125001_2 - 2.6 8.4 41.5 0.17 12.2 2.1 7.5 8 2 0 8 8 8 0 Flagella accessory protein C (FlaC) DUF4248 PF14053.4 001100066.2_16125001_2 - 3.7 7.6 6.6 0.71 9.8 0.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4248) IL22 PF14565.4 001020792.1_16122001_1 - 2.3e-05 24.6 0.1 3.1e-05 24.1 0.1 1.2 1 0 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor Rb_C PF08934.8 204419.1_23529001_2 - 4.1e-80 266.8 2.5 4.1e-80 266.8 2.5 2.0 3 0 0 3 3 3 1 Rb C-terminal domain RB_A PF01858.15 204419.1_23529001_2 - 4.2e-77 258.4 1.3 8.3e-77 257.4 0.1 2.1 2 0 0 2 2 2 1 Retinoblastoma-associated protein A domain RB_B PF01857.18 204419.1_23529001_2 - 1.9e-33 115.1 7.3 1.3e-31 109.2 3.5 2.8 2 0 0 2 2 2 2 Retinoblastoma-associated protein B domain DUF3452 PF11934.6 204419.1_23529001_2 - 3.1e-13 49.3 3.3 3.1e-13 49.3 3.3 4.0 5 0 0 5 5 5 1 Domain of unknown function (DUF3452) DUF413 PF04219.10 204419.1_23529001_2 - 0.098 12.6 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF CAF1C_H4-bd PF12265.6 204670.1_23524001_3 - 7.7e-27 93.2 0.5 3.2e-26 91.2 0.3 2.1 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.30 204670.1_23524001_3 - 7.6e-26 89.7 15.3 4.7e-07 30.3 0.0 6.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 204670.1_23524001_3 - 5.1e-05 23.4 0.9 0.0084 16.3 0.0 3.3 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Capsid_NCLDV PF04451.10 204670.1_23524001_3 - 0.026 14.2 0.0 0.047 13.3 0.0 1.4 1 0 0 1 1 1 0 Large eukaryotic DNA virus major capsid protein Na_Ca_ex PF01699.22 001001773.1_23525001_3 - 8.2e-57 191.3 48.9 4.2e-30 104.6 24.4 2.6 3 0 0 3 3 3 2 Sodium/calcium exchanger protein PBP1_TM PF14812.4 001001773.1_23525001_3 - 0.056 13.8 3.9 0.15 12.4 3.1 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.11 001001773.1_23525001_3 - 0.52 8.2 14.4 0.73 7.7 14.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF1510 PF07423.9 001001773.1_23525001_3 - 1.6 8.0 14.1 4.4 6.5 14.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) SURF2 PF05477.9 001001773.1_23525001_3 - 1.7 8.0 9.5 2.5 7.4 9.5 1.3 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) CDC45 PF02724.12 001001773.1_23525001_3 - 2.6 6.1 6.5 3.9 5.5 6.5 1.2 1 0 0 1 1 1 0 CDC45-like protein EAP30 PF04157.14 199977.1_16124001_1 - 3.9e-42 144.0 1.0 5.4e-42 143.6 1.0 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.6 199977.1_16124001_1 - 9.1e-15 54.5 0.0 1.7e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 Cpn60_TCP1 PF00118.22 001012916.2_23525001_2 - 9.3e-87 291.6 17.6 2.3e-86 290.3 17.6 1.5 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family 4HB_MCP_1 PF12729.5 001012916.2_23525001_2 - 2.3 7.6 6.1 4.6 6.6 1.8 2.3 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction STAT_bind PF02864.13 001004510.1_16125001_1 - 9.6e-76 254.8 2.0 9.6e-76 254.8 2.0 2.8 2 2 1 3 3 3 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 001004510.1_16125001_1 - 1.7e-47 161.5 6.5 1.7e-47 161.5 6.5 1.9 2 0 0 2 2 2 1 STAT protein, all-alpha domain STAT_int PF02865.15 001004510.1_16125001_1 - 2.8e-37 127.8 7.2 2.8e-37 127.8 7.2 2.4 2 0 0 2 2 2 1 STAT protein, protein interaction domain SH2 PF00017.22 001004510.1_16125001_1 - 1.3e-11 44.2 0.0 9.4e-11 41.5 0.0 2.3 2 0 0 2 2 2 1 SH2 domain NPV_P10 PF05531.10 001004510.1_16125001_1 - 0.32 11.4 2.1 0.99 9.8 2.1 1.9 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Ribosomal_S19 PF00203.19 205462.1_23521001_1 - 1.4e-40 136.9 0.4 2e-40 136.4 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Prok_Ub PF14454.4 205462.1_23521001_1 - 0.019 14.4 0.1 0.05 13.1 0.1 1.6 1 0 0 1 1 1 0 Prokaryotic Ubiquitin MAP65_ASE1 PF03999.10 205462.1_23521001_1 - 0.026 13.1 0.8 0.031 12.9 0.8 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) LCAT PF02450.13 205462.1_23521001_1 - 0.13 11.3 0.1 0.17 10.9 0.1 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase PDEase_I PF00233.17 204986.1_23529001_1 - 4.6e-81 271.9 2.7 4.6e-81 271.9 2.7 2.1 3 0 0 3 3 3 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.24 204986.1_23529001_1 - 1.6e-22 80.3 0.0 1.2e-11 45.1 0.0 2.3 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.4 204986.1_23529001_1 - 1.2e-09 38.5 0.0 0.00038 20.6 0.0 2.3 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.4 204986.1_23529001_1 - 4.5e-07 30.1 0.0 0.018 15.3 0.0 2.6 2 1 0 2 2 2 2 GAF domain SpoVT_C PF15714.3 204986.1_23529001_1 - 0.012 15.5 0.0 0.85 9.5 0.0 2.9 2 0 0 2 2 2 0 Stage V sporulation protein T C-terminal, transcription factor CAMSAP_CC1 PF17095.3 204986.1_23529001_1 - 0.05 13.3 1.0 0.092 12.5 0.2 1.8 2 0 0 2 2 2 0 Spectrin-binding region of Ca2+-Calmodulin TFCD_C PF12612.6 001012801.1_23529001_1 - 1.2e-37 129.5 0.0 8e-37 126.8 0.0 2.4 3 0 0 3 3 3 1 Tubulin folding cofactor D C terminal HEAT_EZ PF13513.4 001012801.1_23529001_1 - 1.4e-06 28.5 1.6 0.13 12.6 0.0 5.9 7 1 1 8 8 8 2 HEAT-like repeat HEAT_2 PF13646.4 001012801.1_23529001_1 - 0.0082 16.4 0.4 2.9 8.2 0.0 3.9 4 0 0 4 4 4 1 HEAT repeats HEAT PF02985.20 001012801.1_23529001_1 - 0.016 15.2 6.7 0.45 10.7 0.0 5.7 8 0 0 8 8 8 0 HEAT repeat STAG PF08514.9 001012801.1_23529001_1 - 0.033 14.0 0.4 5.9 6.7 0.0 2.8 2 0 0 2 2 2 0 STAG domain HEAT_PBS PF03130.14 001012801.1_23529001_1 - 0.63 10.8 3.8 41 5.1 0.0 5.3 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat TFCD_C PF12612.6 001012801.1_23529001_2 - 1.7e-09 37.7 0.0 2.5e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal MitoNEET_N PF10660.7 200383.1_16123001_2 - 1.2e-23 82.8 0.2 1.8e-23 82.2 0.2 1.3 1 0 0 1 1 1 1 Iron-containing outer mitochondrial membrane protein N-terminus zf-CDGSH PF09360.8 200383.1_16123001_2 - 2.2e-08 34.1 1.3 2.7e-08 33.8 0.2 1.7 2 0 0 2 2 2 1 Iron-binding zinc finger CDGSH type PGA2 PF07543.10 200383.1_16123001_2 - 0.16 11.8 0.0 0.16 11.8 0.0 2.2 3 0 0 3 3 3 0 Protein trafficking PGA2 Ferritin PF00210.22 205086.1_23522001_2 - 2e-38 131.4 5.4 2.6e-38 131.0 5.4 1.1 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.15 205086.1_23522001_2 - 0.012 15.8 0.6 0.017 15.4 0.6 1.3 1 0 0 1 1 1 0 Rubrerythrin Peptidase_C54 PF03416.17 213573.1_23523001_1 - 5.4e-100 334.0 0.0 6.5e-100 333.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 CH PF00307.29 205494.1_23523001_2 - 1.8e-17 63.3 0.0 2.8e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain Calponin PF00402.16 205494.1_23523001_2 - 1.3e-13 50.2 4.9 2.1e-13 49.5 3.4 2.1 2 0 0 2 2 2 1 Calponin family repeat 14-3-3 PF00244.18 001006219.1_23523001_3 - 5.9e-107 356.1 2.5 7.2e-107 355.8 2.5 1.1 1 0 0 1 1 1 1 14-3-3 protein Orbi_VP5 PF00901.15 001006219.1_23523001_3 - 0.084 11.1 3.7 0.13 10.5 3.7 1.2 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 MKRN1_C PF15815.3 152978.1_16124001_2 - 1.4e-39 134.2 6.7 2.6e-39 133.4 6.7 1.4 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase makorin-1, C-terminal Torus PF16131.3 152978.1_16124001_2 - 1.3e-19 70.7 20.1 4.4e-06 27.2 3.0 4.4 3 1 1 4 4 4 4 Torus domain zf-CCCH PF00642.22 152978.1_16124001_2 - 6.5e-16 57.7 36.5 0.00039 20.1 0.3 4.5 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 152978.1_16124001_2 - 6.5e-06 26.3 36.3 0.21 12.0 3.6 4.9 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.3 152978.1_16124001_2 - 0.00033 20.8 10.0 0.00033 20.8 10.0 2.8 3 0 0 3 3 3 1 Zinc-finger containing family zf-RING_2 PF13639.4 152978.1_16124001_2 - 0.00098 19.2 12.7 0.00098 19.2 12.7 3.5 3 1 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.23 152978.1_16124001_2 - 0.0033 17.1 13.4 0.0033 17.1 13.4 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 152978.1_16124001_2 - 0.014 15.2 8.6 0.05 13.5 8.6 2.0 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.4 152978.1_16124001_2 - 0.11 12.4 17.6 0.023 14.5 12.7 2.6 2 0 0 2 2 2 0 zinc-RING finger domain Pou PF00157.15 131278.1_16122001_1 - 2.6e-31 107.3 0.0 6e-31 106.2 0.0 1.7 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 131278.1_16122001_1 - 2.4e-17 62.3 1.7 5.6e-17 61.2 1.7 1.7 1 0 0 1 1 1 1 Homeobox domain HTH_31 PF13560.4 131278.1_16122001_1 - 0.00057 20.1 0.0 0.032 14.5 0.0 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain Homeobox_KN PF05920.9 131278.1_16122001_1 - 0.12 12.2 0.1 0.26 11.1 0.1 1.6 1 0 0 1 1 1 0 Homeobox KN domain Cyclin_N PF00134.21 205381.1_23523001_1 - 1.4e-37 128.2 3.6 1.4e-37 128.2 2.3 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 205381.1_23523001_1 - 8.2e-20 70.9 2.1 1.2e-19 70.4 0.3 2.1 2 1 0 2 2 2 1 Cyclin, C-terminal domain EOS1 PF12326.6 213128.1_16125001_2 - 0.99 9.2 6.9 0.72 9.6 5.5 1.4 2 0 0 2 2 2 0 N-glycosylation protein Presenilin PF01080.15 213128.1_16125001_2 - 2.9 6.4 4.2 3.6 6.1 4.2 1.1 1 0 0 1 1 1 0 Presenilin Paf67 PF10255.7 213128.1_16125001_3 - 1.6e-178 593.7 10.9 1.6e-178 593.7 10.9 1.7 2 0 0 2 2 2 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.15 213128.1_16125001_3 - 0.0055 16.6 0.5 0.08 13.0 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.26 213128.1_16125001_3 - 0.029 14.1 0.3 0.73 9.6 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat EOS1 PF12326.6 213128.1_16125001_3 - 0.13 12.0 0.5 0.24 11.2 0.5 1.6 1 0 0 1 1 1 0 N-glycosylation protein Connexin PF00029.17 213128.1_16125001_3 - 1.5 8.4 11.4 3.3 7.3 11.4 1.6 1 0 0 1 1 1 0 Connexin PDZ PF00595.22 204839.2_23523001_1 - 1.4e-17 63.7 0.0 2.3e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) DUF4749 PF15936.3 204839.2_23523001_1 - 1.4e-16 61.3 0.1 2.3e-16 60.6 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) LIM PF00412.20 204839.2_23523001_1 - 1.5e-14 53.9 3.7 2.5e-14 53.1 3.7 1.3 1 0 0 1 1 1 1 LIM domain PDZ_2 PF13180.4 204839.2_23523001_1 - 0.0012 18.9 0.0 0.0026 17.9 0.0 1.5 1 0 0 1 1 1 1 PDZ domain BNR_2 PF13088.4 204839.2_23523001_1 - 0.027 13.7 0.0 0.038 13.1 0.0 1.1 1 0 0 1 1 1 0 BNR repeat-like domain PEPCK PF00821.16 205470.1_23528001_1 - 2.7e-258 858.0 0.0 3.1e-258 857.7 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase DEAD PF00270.27 130941.2_16129001_1 - 3.8e-50 169.9 0.0 1.5e-49 168.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 130941.2_16129001_1 - 6e-31 107.0 0.0 1.1e-30 106.2 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ETRAMP PF09716.8 130941.2_16129001_3 - 0.0026 17.6 1.2 0.0054 16.6 1.2 1.5 1 0 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) S1 PF00575.21 199669.1_16123001_2 - 1.1e-19 70.4 0.2 1.8e-19 69.7 0.2 1.3 1 0 0 1 1 1 1 S1 RNA binding domain SHS2_Rpb7-N PF03876.15 199669.1_16123001_2 - 2.7e-14 53.1 0.0 4.2e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rbc25 PF08292.10 199669.1_16123001_2 - 0.00052 20.1 0.1 0.00085 19.4 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 Glyco_transf_29 PF00777.16 205217.1_23524001_3 - 1.2e-80 270.6 0.0 1.6e-80 270.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Lysis_col PF02402.14 205217.1_23524001_3 - 2.7 7.8 5.4 0.71 9.7 0.6 2.3 2 0 0 2 2 2 0 Lysis protein LIM PF00412.20 205426.1_23524001_1 - 1.2e-31 108.5 21.5 3.9e-16 58.9 4.0 2.3 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 205426.1_23524001_1 - 1.5e-17 63.0 2.8 3.3e-17 61.9 2.8 1.6 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 205426.1_23524001_1 - 0.00013 21.7 4.3 0.00075 19.2 4.3 2.2 1 1 0 1 1 1 1 Homeobox KN domain Homez PF11569.6 205426.1_23524001_1 - 0.01 15.2 0.0 0.023 14.0 0.0 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez TNFR_c6 PF00020.16 205426.1_23524001_1 - 9.6 6.6 15.8 9.5 6.6 0.6 3.7 3 0 0 3 3 3 0 TNFR/NGFR cysteine-rich region NdhL PF10716.7 001012930.1_23526001_2 - 0.19 11.6 2.5 0.4 10.5 2.5 1.4 1 0 0 1 1 1 0 NADH dehydrogenase transmembrane subunit BTB PF00651.29 001012930.1_23526001_3 - 4.5e-27 94.3 0.3 7.4e-27 93.6 0.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 001012930.1_23526001_3 - 5.6e-22 77.0 55.7 1.1e-06 28.6 0.5 6.9 8 0 0 8 8 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 001012930.1_23526001_3 - 4e-17 61.5 59.2 4.3e-05 23.6 0.3 7.5 7 0 0 7 7 6 6 Zinc finger, C2H2 type zf-met PF12874.5 001012930.1_23526001_3 - 8.4e-11 41.8 35.2 0.00032 20.8 0.1 7.1 6 0 0 6 6 6 3 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.4 001012930.1_23526001_3 - 7e-10 38.8 57.2 0.015 15.9 1.1 7.8 7 0 0 7 7 6 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001012930.1_23526001_3 - 0.0002 21.5 21.1 0.62 10.3 2.1 6.1 6 0 0 6 6 5 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 001012930.1_23526001_3 - 0.025 14.2 0.9 0.025 14.2 0.9 7.1 6 2 0 6 6 6 0 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.4 001012930.1_23526001_3 - 0.026 14.3 0.0 0.026 14.3 0.0 6.6 7 0 0 7 7 6 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001012930.1_23526001_3 - 0.028 14.4 0.9 0.028 14.4 0.9 5.5 4 3 3 7 7 7 0 Zinc ribbon domain DUF3342 PF11822.6 001012930.1_23526001_3 - 0.039 14.0 0.4 0.09 12.8 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) zf-C2HE PF16278.3 001012930.1_23526001_3 - 0.51 10.7 37.6 0.25 11.7 0.3 6.8 1 1 5 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger DUF3268 PF11672.6 001012930.1_23526001_3 - 2.3 8.4 14.2 1.5 9.1 0.3 3.9 3 1 1 4 4 4 0 zinc-finger-containing domain zinc_ribbon_15 PF17032.3 001012930.1_23526001_3 - 3.1 8.5 25.3 20 5.9 0.4 5.0 2 1 2 4 4 4 0 zinc-ribbon family GAGA PF09237.9 001012930.1_23526001_3 - 3.9 7.2 17.2 8.5 6.1 0.1 4.9 1 1 4 5 5 5 0 GAGA factor Ribosomal_L27e PF01777.16 205337.1_23521001_3 - 1.6e-39 134.0 8.9 2.3e-39 133.5 8.9 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.27 205337.1_23521001_3 - 5.2e-06 26.1 0.1 1.2e-05 24.9 0.1 1.6 1 0 0 1 1 1 1 KOW motif Spectrin PF00435.19 205323.1_23527001_1 - 4e-71 236.0 34.3 5.3e-23 81.4 8.4 4.4 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.29 205323.1_23527001_1 - 1.5e-53 179.5 0.4 5.2e-27 94.1 0.0 2.9 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.8 205323.1_23527001_1 - 1.1e-27 95.8 0.0 4.8e-27 93.7 0.0 2.3 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_1 PF00036.30 205323.1_23527001_1 - 1.2e-08 33.7 1.0 0.0045 16.3 0.0 2.8 2 0 0 2 2 2 2 EF hand CAMSAP_CH PF11971.6 205323.1_23527001_1 - 2.1e-08 33.8 0.0 3.6e-07 29.8 0.0 2.5 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_7 PF13499.4 205323.1_23527001_1 - 3.3e-06 27.3 1.5 8e-06 26.1 0.3 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.4 205323.1_23527001_1 - 4.9e-06 26.1 3.3 6e-06 25.8 0.4 2.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.4 205323.1_23527001_1 - 8.5e-05 22.1 3.1 0.02 14.6 0.5 3.1 3 0 0 3 3 3 2 EF-hand domain IATP PF04568.10 205323.1_23527001_1 - 0.043 14.1 5.1 0.31 11.4 0.5 3.2 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP EF-hand_11 PF08976.9 205323.1_23527001_1 - 0.063 14.0 0.2 0.24 12.2 0.1 2.1 2 0 0 2 2 1 0 EF-hand domain XisI PF08869.9 205323.1_23527001_1 - 0.22 11.8 6.8 0.054 13.7 1.3 2.6 2 0 0 2 2 2 0 XisI protein Ank_4 PF13637.4 205123.1_23529001_1 - 4.3e-36 122.7 1.4 9.7e-15 54.6 0.1 5.4 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.5 205123.1_23529001_1 - 6.8e-36 122.6 3.2 9.2e-18 64.5 0.2 3.6 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 205123.1_23529001_1 - 1.8e-31 107.6 8.1 2.7e-10 40.2 0.3 5.1 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.28 205123.1_23529001_1 - 3e-26 90.6 1.0 1.3e-05 25.3 0.1 6.9 7 0 0 7 7 7 4 Ankyrin repeat Ank_3 PF13606.4 205123.1_23529001_1 - 1.4e-23 80.2 2.5 4.2e-06 26.6 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat PRKG1_interact PF15898.3 205123.1_23529001_1 - 2.2e-08 34.8 5.3 2.2e-08 34.8 5.3 5.7 5 1 0 5 5 5 1 cGMP-dependent protein kinase interacting domain PRKG1_interact PF15898.3 205123.1_23529001_2 - 8.4e-19 68.3 0.2 8.4e-19 68.3 0.2 2.6 2 0 0 2 2 2 1 cGMP-dependent protein kinase interacting domain Protocadherin PF08374.9 205123.1_23529001_2 - 0.19 11.6 3.1 0.38 10.6 3.1 1.4 1 0 0 1 1 1 0 Protocadherin Homeobox PF00046.27 204193.1_23523001_3 - 7.4e-21 73.6 2.1 1.4e-20 72.7 2.1 1.5 1 0 0 1 1 1 1 Homeobox domain CK2S PF15011.4 173269.1_16122001_3 - 2.1e-47 160.8 3.2 3.2e-47 160.2 3.2 1.3 1 0 0 1 1 1 1 Casein Kinase 2 substrate YgaB PF14182.4 173269.1_16122001_3 - 0.041 14.2 0.7 0.64 10.4 0.1 2.5 2 0 0 2 2 2 0 YgaB-like protein Kelch_1 PF01344.23 001007328.1_16126001_2 - 1e-78 258.6 19.6 1.2e-14 53.4 0.3 6.9 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.4 001007328.1_16126001_2 - 3.6e-46 153.9 10.9 1.2e-09 37.9 0.1 6.4 2 2 4 6 6 6 6 Kelch motif BACK PF07707.13 001007328.1_16126001_2 - 9e-34 115.5 0.6 1.5e-33 114.8 0.6 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 001007328.1_16126001_2 - 2.8e-30 104.6 0.3 2.8e-30 104.6 0.3 1.7 2 0 0 2 2 2 1 BTB/POZ domain Kelch_4 PF13418.4 001007328.1_16126001_2 - 9.4e-29 99.0 7.3 0.00039 20.2 0.0 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.13 001007328.1_16126001_2 - 3.6e-27 93.1 3.5 6.7e-05 22.6 0.0 6.7 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.4 001007328.1_16126001_2 - 3.7e-27 93.9 10.6 1.8e-09 37.5 0.6 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.4 001007328.1_16126001_2 - 2.2e-13 49.7 9.4 0.01 15.7 0.1 5.9 6 0 0 6 6 6 4 Kelch motif Ion_trans PF00520.29 204293.1_23529001_2 - 7.8e-253 834.0 79.6 8.3e-68 228.1 2.1 4.2 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.3 204293.1_23529001_2 - 1e-35 121.2 0.0 3.5e-35 119.5 0.0 2.0 2 0 0 2 2 2 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 204293.1_23529001_2 - 2.6e-32 110.8 0.0 6.3e-32 109.6 0.0 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 204293.1_23529001_2 - 1.3e-06 27.2 35.2 3.8e-06 25.7 9.9 9.2 6 4 2 9 9 9 4 Polycystin cation channel Tmemb_9 PF05434.9 204293.1_23529001_2 - 0.21 11.3 1.8 10 5.9 0.0 3.1 2 0 0 2 2 2 0 TMEM9 Ferlin_C PF16165.3 204293.1_23529001_2 - 2.6 7.8 0.0 2.6 7.8 0.0 4.9 6 0 0 6 6 6 0 Ferlin C-terminus Forkhead PF00250.16 205193.1_23524001_1 - 5.6e-39 132.2 0.1 1e-38 131.4 0.1 1.4 1 0 0 1 1 1 1 Forkhead domain SelP_N PF04592.12 205193.1_23524001_1 - 0.33 10.2 18.7 0.81 8.9 17.4 2.1 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Mito_fiss_reg PF05308.9 205193.1_23524001_3 - 0.91 9.4 7.8 1.9 8.4 7.8 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator Lustrin_cystein PF14625.4 131208.1_16123001_2 - 3.7 7.9 7.4 1.5 9.2 4.2 2.0 2 0 0 2 2 2 0 Lustrin, cysteine-rich repeated domain LIM PF00412.20 131208.1_16123001_3 - 7.1e-32 109.3 20.7 7.1e-17 61.2 3.5 2.3 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 131208.1_16123001_3 - 6e-21 73.9 2.4 1e-20 73.2 2.4 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 131208.1_16123001_3 - 0.00021 21.0 0.1 0.00055 19.7 0.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain Furin-like_2 PF15913.3 131208.1_16123001_3 - 0.49 10.4 13.6 0.044 13.8 8.3 2.0 1 1 1 2 2 2 0 Furin-like repeat, cysteine-rich C1_1 PF00130.20 131208.1_16123001_3 - 6.7 6.6 18.9 5.3 6.9 7.2 2.6 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHF5 PF03660.12 131208.1_16123001_3 - 7.8 6.6 11.9 0.13 12.3 2.3 2.2 1 1 1 2 2 2 0 PHF5-like protein ASC PF00858.22 205145.2_23527001_2 - 8.6e-101 337.7 11.6 1.3e-100 337.1 11.6 1.3 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Pkinase PF00069.23 001002242.1_23524001_1 - 3.9e-72 242.7 0.3 4.6e-72 242.4 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001002242.1_23524001_1 - 2.4e-20 72.8 0.0 3.3e-20 72.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001002242.1_23524001_1 - 9.8e-08 32.1 0.1 1e-05 25.5 0.1 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.12 001002242.1_23524001_1 - 0.00054 19.3 0.1 0.00088 18.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.18 001002242.1_23524001_1 - 0.012 15.1 0.2 0.027 13.9 0.2 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kinase-like PF14531.4 001002242.1_23524001_1 - 0.017 14.3 0.1 0.069 12.3 0.0 1.9 2 0 0 2 2 2 0 Kinase-like ABC1 PF03109.14 001002242.1_23524001_1 - 0.093 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 ABC1 family FTA2 PF13095.4 001002242.1_23524001_1 - 0.15 11.5 0.3 1.7 8.1 0.0 2.5 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Sugar_tr PF00083.22 200538.1_16125001_2 - 6.8e-86 288.8 21.2 4.7e-62 210.2 9.8 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.14 200538.1_16125001_2 - 3.7e-23 81.9 35.9 2.3e-13 49.7 18.4 2.9 2 1 0 3 3 3 3 Major Facilitator Superfamily Phage_holin_3_2 PF04550.10 200538.1_16125001_2 - 4.3 7.7 7.2 1.6 9.1 2.4 2.8 2 1 1 3 3 3 0 Phage holin family 2 RNA_pol_Rpb1_1 PF04997.10 001006500.1_23529001_1 - 1e-96 323.8 1.9 1.7e-96 323.1 1.9 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.15 001006500.1_23529001_1 - 1.6e-88 296.5 0.1 2.4e-88 295.9 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.18 001006500.1_23529001_1 - 4.7e-75 251.2 0.1 8.5e-75 250.4 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.16 001006500.1_23529001_1 - 2.1e-42 144.6 0.0 5.8e-41 139.9 0.0 3.1 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.15 001006500.1_23529001_1 - 2.2e-32 111.1 0.0 8.5e-32 109.2 0.0 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 LIN52 PF10044.7 001007937.1_23527001_2 - 1.4e-37 128.1 0.1 2.6e-37 127.3 0.1 1.4 1 0 0 1 1 1 1 Retinal tissue protein Rad51 PF08423.9 205173.1_23523001_3 - 1.4e-129 430.7 0.0 1.8e-129 430.3 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.4 205173.1_23523001_3 - 3.7e-11 42.8 0.0 5.6e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.19 205173.1_23523001_3 - 4.6e-09 36.0 0.1 7.2e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.4 205173.1_23523001_3 - 7.8e-09 35.9 0.4 2.7e-08 34.2 0.4 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.11 205173.1_23523001_3 - 4.7e-05 22.7 1.2 0.00024 20.4 1.2 2.0 1 1 0 1 1 1 1 KaiC HHH PF00633.21 205173.1_23523001_3 - 0.019 14.7 0.1 0.041 13.6 0.1 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif AAA_22 PF13401.4 205173.1_23523001_3 - 0.032 14.4 0.0 0.076 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.13 205173.1_23523001_3 - 0.047 12.8 0.0 1.9 7.6 0.0 2.2 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA_24 PF13479.4 205173.1_23523001_3 - 0.097 12.2 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain GATA PF00320.25 001008444.1_23524001_1 - 6.7e-29 99.1 19.6 2.1e-14 52.7 5.3 2.5 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.10 001008444.1_23524001_1 - 3.6e-05 23.1 8.3 0.028 13.8 0.7 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding DUF2387 PF09526.8 001008444.1_23524001_1 - 0.023 14.7 5.2 3.5 7.7 0.5 3.5 1 1 2 3 3 3 0 Probable metal-binding protein (DUF2387) Zn-ribbon_8 PF09723.8 001008444.1_23524001_1 - 0.024 14.6 2.1 3.4 7.8 0.1 2.8 2 0 0 2 2 2 0 Zinc ribbon domain Auto_anti-p27 PF06677.10 001008444.1_23524001_1 - 0.14 12.2 5.2 1.6 8.8 0.4 2.5 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Prim_Zn_Ribbon PF08273.10 001008444.1_23524001_1 - 0.97 9.7 11.3 0.3 11.3 2.6 2.8 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DZR PF12773.5 001008444.1_23524001_1 - 1.9 8.5 11.8 6.5 6.7 2.0 2.9 1 1 2 3 3 3 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.9 001008444.1_23524001_1 - 3.2 7.6 11.0 3.4 7.5 1.2 3.1 3 0 0 3 3 3 0 Putative transposase DNA-binding domain Popeye PF04831.11 204697.2_23524001_1 - 7.6e-51 171.8 1.8 1.1e-50 171.3 1.8 1.2 1 0 0 1 1 1 1 Popeye protein conserved region WD40 PF00400.30 001006162.1_23525001_1 - 0.00014 22.4 0.0 6.9 7.6 0.0 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001006162.1_23525001_1 - 0.0052 16.9 0.0 0.33 11.1 0.0 3.3 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001006162.1_23525001_1 - 0.033 13.0 0.8 9.2 5.0 0.1 3.1 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein F-actin_cap_A PF01267.15 001004380.1_23526001_3 - 4.3e-107 357.4 2.4 5.5e-107 357.0 2.4 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit Homeobox PF00046.27 207177.1_23523001_1 - 7.3e-21 73.6 5.8 1.5e-20 72.6 5.8 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 207177.1_23523001_1 - 0.0091 15.8 0.1 0.023 14.5 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain RskA PF10099.7 207177.1_23523001_1 - 0.021 15.0 5.8 0.033 14.4 5.8 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DNA_topoisoIV PF00521.18 204791.1_23529001_1 - 1e-131 439.6 0.0 2.2e-131 438.5 0.0 1.6 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.3 204791.1_23529001_1 - 2.1e-49 166.9 4.9 6e-49 165.4 4.9 1.9 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.23 204791.1_23529001_1 - 2e-27 95.6 1.5 4.1e-27 94.7 1.5 1.5 1 0 0 1 1 1 1 DNA gyrase B DTHCT PF08070.9 204791.1_23529001_1 - 1.8e-23 83.1 13.6 1.8e-23 83.1 13.6 5.1 2 1 4 6 6 6 2 DTHCT (NUC029) region HATPase_c PF02518.24 204791.1_23529001_1 - 3.6e-16 59.6 0.0 1.7e-15 57.5 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.20 204791.1_23529001_1 - 2e-09 37.5 0.0 5.3e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 Toprim domain Ion_trans PF00520.29 205039.1_23524001_1 - 3e-38 131.3 3.2 4.2e-38 130.8 3.2 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 205039.1_23524001_1 - 6.3e-28 96.8 0.0 1.4e-27 95.7 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 205039.1_23524001_1 - 3.1e-14 52.5 4.5 7e-14 51.4 2.3 2.3 2 0 0 2 2 2 1 Ion channel Torus PF16131.3 205039.1_23524001_3 - 2.8 8.5 5.5 34 5.1 0.1 2.4 2 0 0 2 2 2 0 Torus domain ATP-synt_D PF01813.15 001013295.2_16122001_2 - 0.00069 19.4 7.1 0.021 14.6 6.2 2.7 1 1 0 1 1 1 1 ATP synthase subunit D RHD_DNA_bind PF00554.20 205134.1_23529001_2 - 2e-70 236.0 0.0 3.3e-70 235.3 0.0 1.4 1 0 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.3 205134.1_23529001_2 - 1.8e-41 140.3 0.0 3.8e-41 139.2 0.0 1.6 1 0 0 1 1 1 1 Rel homology dimerisation domain Ank_2 PF12796.5 205134.1_23529001_2 - 6.8e-27 93.8 20.2 6.9e-11 42.5 0.3 4.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.4 205134.1_23529001_2 - 6.8e-24 83.8 2.0 2.2e-09 37.5 0.0 6.0 3 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.28 205134.1_23529001_2 - 1.2e-20 72.8 13.9 1.3e-05 25.2 0.1 7.4 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.4 205134.1_23529001_2 - 2.1e-20 72.3 10.4 3.4e-07 30.3 0.3 5.4 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 205134.1_23529001_2 - 1.1e-17 62.2 7.1 0.053 14.0 0.0 6.9 7 0 0 7 7 7 5 Ankyrin repeat Death PF00531.20 205134.1_23529001_2 - 1.2e-12 47.7 0.0 2.3e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 Death domain zf-SAP30 PF13866.4 214703.1_16124001_1 - 2.4e-37 126.7 3.4 4.4e-37 125.8 3.4 1.5 1 0 0 1 1 1 1 SAP30 zinc-finger SAP30_Sin3_bdg PF13867.4 214703.1_16124001_1 - 9.1e-25 86.6 0.7 1.7e-24 85.8 0.7 1.4 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Tetraspannin PF00335.18 131567.1_16125001_1 - 4.6e-25 88.5 6.8 7.4e-25 87.9 6.8 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF4736 PF15883.3 131567.1_16125001_1 - 0.16 11.5 0.7 0.41 10.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4736) DUF3528 PF12045.6 131165.2_16124001_3 - 7.1e-61 204.8 3.2 1.2e-60 204.1 3.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3528) Homeobox PF00046.27 131165.2_16124001_3 - 2.7e-19 68.6 8.1 4.7e-19 67.8 8.1 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 131165.2_16124001_3 - 0.061 13.1 0.7 0.15 11.9 0.7 1.6 1 0 0 1 1 1 0 Homeobox KN domain DUF3528 PF12045.6 204619.1_23525001_1 - 1.5e-64 216.7 1.3 2.3e-64 216.1 1.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3528) Homeobox PF00046.27 204619.1_23525001_1 - 1.3e-19 69.7 7.4 2.3e-19 68.8 7.4 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 204619.1_23525001_1 - 0.13 12.1 0.8 0.28 11.0 0.8 1.5 1 0 0 1 1 1 0 Homeobox KN domain Ribosomal_L36e PF01158.16 204140.1_23521001_2 - 1e-50 169.8 7.4 1.4e-50 169.4 7.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L36e Ras PF00071.20 001012549.1_23529001_3 - 2.2e-56 189.8 0.1 3e-56 189.3 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001012549.1_23529001_3 - 2.1e-19 69.8 0.0 3.2e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001012549.1_23529001_3 - 2.2e-07 30.4 0.0 3.4e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001012549.1_23529001_3 - 0.0001 21.8 0.1 0.00021 20.8 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001012549.1_23529001_3 - 0.00059 19.6 0.0 0.39 10.5 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 001012549.1_23529001_3 - 0.004 17.1 0.0 0.0059 16.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001012549.1_23529001_3 - 0.1 12.0 0.0 0.23 10.8 0.0 1.6 1 1 0 1 1 1 0 Ferrous iron transport protein B JAB PF01398.19 001030951.1_23523001_1 - 4.8e-24 84.5 0.5 4.8e-24 84.5 0.5 1.9 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Cyclin_N PF00134.21 001031358.1_23525001_3 - 3.1e-43 146.5 1.8 5.1e-43 145.8 1.8 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001031358.1_23525001_3 - 7.3e-20 71.1 0.0 1.3e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain Acyltransferase PF01553.19 001044341.2_16125001_2 - 6.5e-17 61.3 0.0 1.1e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase EF-hand_8 PF13833.4 001044341.2_16125001_2 - 4.6e-08 32.6 0.8 2.1e-07 30.5 0.5 2.4 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.4 001044341.2_16125001_2 - 4.1e-05 23.8 0.3 0.00013 22.2 0.3 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 001044341.2_16125001_2 - 0.00017 21.1 0.1 0.011 15.5 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.30 001044341.2_16125001_2 - 0.00021 20.5 0.5 0.0036 16.6 0.2 2.6 2 0 0 2 2 2 1 EF hand Kelch_1 PF01344.23 001044853.3_16125001_2 - 1.6e-40 136.3 15.5 1.4e-09 37.2 0.0 5.9 5 1 0 5 5 5 5 Kelch motif Kelch_6 PF13964.4 001044853.3_16125001_2 - 9.5e-33 111.3 5.1 1.3e-05 25.1 0.0 5.6 2 1 3 5 5 5 5 Kelch motif BTB PF00651.29 001044853.3_16125001_2 - 9.6e-29 99.7 0.1 2e-28 98.7 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 001044853.3_16125001_2 - 7e-26 90.2 0.9 1.3e-25 89.3 0.9 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_2 PF07646.13 001044853.3_16125001_2 - 6.3e-20 70.2 10.7 9.8e-05 22.1 0.1 6.5 6 1 0 6 6 6 4 Kelch motif Kelch_4 PF13418.4 001044853.3_16125001_2 - 1.2e-18 66.6 1.5 0.0021 17.8 0.0 6.0 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.4 001044853.3_16125001_2 - 1.2e-13 50.9 0.7 0.026 14.7 0.0 5.4 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.4 001044853.3_16125001_2 - 4.8e-09 35.9 10.2 0.021 14.7 0.1 5.6 5 0 0 5 5 5 3 Kelch motif Skp1_POZ PF03931.13 001044853.3_16125001_2 - 0.079 13.0 0.0 0.45 10.6 0.0 2.2 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain Cofilin_ADF PF00241.18 001030589.1_23526001_1 - 1.4e-40 138.3 2.4 5.1e-22 78.2 0.7 2.6 3 0 0 3 3 3 2 Cofilin/tropomyosin-type actin-binding protein HoxA13_N PF12284.6 131546.2_16124001_3 - 5.3e-32 110.8 6.0 8.8e-32 110.1 6.0 1.4 1 0 0 1 1 1 1 Hox protein A13 N terminal Homeobox PF00046.27 131546.2_16124001_3 - 3.2e-17 62.0 6.8 9.8e-17 60.4 6.3 2.0 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.9 131546.2_16124001_3 - 0.0032 17.2 1.4 0.0065 16.2 1.4 1.5 1 0 0 1 1 1 1 Homeobox KN domain GCIP PF13324.4 001089365.1_16123001_1 - 1.9e-87 293.0 3.0 2.4e-87 292.7 3.0 1.1 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting GTP_EFTU PF00009.25 001031501.1_23527001_1 - 7.5e-46 156.0 0.0 1.2e-45 155.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.3 001031501.1_23527001_1 - 2.1e-39 134.7 9.6 3.5e-39 134.0 9.6 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.16 001031501.1_23527001_1 - 6e-24 84.0 0.0 1.2e-23 83.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.22 001031501.1_23527001_1 - 1.3e-22 79.5 0.0 2.7e-22 78.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.23 001031501.1_23527001_1 - 1.1e-12 48.0 0.0 2.7e-12 46.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.4 001031501.1_23527001_1 - 3.3e-08 33.4 0.0 8.4e-08 32.1 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II Septin PF00735.16 001031501.1_23527001_1 - 0.12 11.4 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Septin UCH PF00443.27 001098386.1_16128001_3 - 4.1e-48 164.0 0.0 5.9e-48 163.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.29 001098386.1_16128001_3 - 7.8e-26 89.4 0.0 1e-11 44.3 0.0 3.4 3 0 0 3 3 3 2 UBA/TS-N domain zf-UBP PF02148.17 001098386.1_16128001_3 - 2.6e-14 53.2 0.0 2.6e-14 53.2 0.0 3.2 4 0 0 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.4 001098386.1_16128001_3 - 4e-08 33.1 0.0 0.0052 16.3 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Myc_N PF01056.16 001030952.1_23523001_1 - 1.3e-116 390.0 12.9 3.2e-116 388.7 12.9 1.7 1 1 0 1 1 1 1 Myc amino-terminal region Myc-LZ PF02344.13 001030952.1_23523001_1 - 5.1e-16 58.3 13.2 5.1e-16 58.3 13.2 2.0 2 0 0 2 2 2 1 Myc leucine zipper domain HLH PF00010.24 001030952.1_23523001_1 - 2.2e-14 53.0 10.5 5.4e-14 51.8 0.8 2.9 3 0 0 3 3 3 2 Helix-loop-helix DNA-binding domain 7tm_1 PF00001.19 001098193.1_16124001_2 - 4.7e-48 163.6 23.4 6.5e-48 163.2 23.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Acyltransferase PF01553.19 001031145.1_23525001_1 - 2.1e-19 69.3 0.4 4.7e-19 68.2 0.1 1.7 2 0 0 2 2 2 1 Acyltransferase CDC73_N PF16050.3 001031265.1_23527001_1 - 5.5e-131 436.2 2.9 7.1e-131 435.8 2.9 1.1 1 0 0 1 1 1 1 Paf1 complex subunit CDC73 N-terminal CDC73_C PF05179.12 001031265.1_23527001_1 - 2.9e-51 173.2 0.0 5.4e-51 172.3 0.0 1.5 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal KH_1 PF00013.27 001031385.1_23524001_2 - 1.7e-43 146.2 13.1 6.1e-20 70.7 1.9 3.3 3 0 0 3 3 3 3 KH domain ROKNT PF08067.9 001031385.1_23524001_2 - 3.4e-24 84.7 9.0 1.1e-22 79.8 11.2 2.1 2 0 0 2 2 2 1 ROKNT (NUC014) domain KH_2 PF07650.15 001031385.1_23524001_2 - 1.3e-14 53.6 3.3 0.0009 18.9 0.5 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.4 001031385.1_23524001_2 - 1.5e-08 34.2 5.6 6.9e-06 25.7 0.0 3.3 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 001031385.1_23524001_2 - 4.2e-05 23.4 2.7 0.35 10.9 0.1 3.4 3 0 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.3 001031385.1_23524001_2 - 0.036 14.0 0.0 1.7 8.6 0.0 2.3 2 0 0 2 2 2 0 KH-like RNA-binding domain DJ-1_PfpI PF01965.22 001031385.1_23524001_2 - 0.091 12.4 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 DJ-1/PfpI family Homeobox PF00046.27 001031120.3_23526001_3 - 6.3e-11 41.8 2.0 8.9e-05 22.1 0.0 2.7 2 0 0 2 2 2 2 Homeobox domain CENP-N PF05238.11 001044670.1_23523001_1 - 1.6e-71 241.6 1.6 5.8e-70 236.5 1.6 2.0 1 1 0 1 1 1 1 Kinetochore protein CHL4 like KOW PF00467.27 001031384.1_23528001_2 - 2.1e-28 97.2 14.5 1.5e-07 31.0 0.2 7.3 8 0 0 8 8 8 6 KOW motif Spt5-NGN PF03439.11 001031384.1_23528001_2 - 3.7e-28 97.1 0.1 6.8e-28 96.3 0.1 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.6 001031384.1_23528001_2 - 5.1e-14 52.9 6.6 5.1e-14 52.9 6.6 3.2 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal DUF3912 PF13051.4 001031384.1_23528001_2 - 0.0057 16.6 0.2 0.72 9.9 0.0 3.3 3 0 0 3 3 3 1 Protein of unknown function (DUF3912) Ribonuc_P_40 PF08584.9 001031384.1_23528001_2 - 0.085 12.0 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit CDC45 PF02724.12 001031384.1_23528001_2 - 0.54 8.4 20.2 0.81 7.8 20.2 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_polI_A34 PF08208.9 001031384.1_23528001_2 - 1.9 8.4 12.4 4.3 7.3 12.4 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 zf-Tim10_DDP PF02953.13 001031093.1_23529001_1 - 0.013 15.0 0.0 0.031 13.8 0.0 1.6 1 0 0 1 1 1 0 Tim10/DDP family zinc finger LIDHydrolase PF10230.7 001031093.1_23529001_3 - 1e-82 277.6 0.1 1.8e-82 276.8 0.0 1.4 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase Abhydrolase_6 PF12697.5 001031093.1_23529001_3 - 0.01 16.3 0.0 0.016 15.7 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Ser_hydrolase PF06821.11 001031093.1_23529001_3 - 0.013 15.3 0.0 0.029 14.1 0.0 1.5 2 0 0 2 2 2 0 Serine hydrolase tRNA-synt_1d PF00750.17 001030607.1_23525001_1 - 2.7e-156 519.8 0.0 4.2e-156 519.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.13 001030607.1_23525001_1 - 9e-32 109.6 0.1 2.2e-31 108.4 0.1 1.7 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.14 001030607.1_23525001_1 - 3.2e-24 85.2 0.1 1.2e-23 83.4 0.1 2.1 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.17 001030607.1_23525001_1 - 0.0055 15.9 0.0 0.016 14.4 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Cnn_1N PF07989.9 001030607.1_23525001_1 - 0.0083 16.1 3.6 0.0095 15.9 1.0 2.3 2 0 0 2 2 2 1 Centrosomin N-terminal motif 1 Nup54 PF13874.4 001030607.1_23525001_1 - 0.075 13.0 0.6 0.17 11.9 0.6 1.6 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 tRNA-synt_1 PF00133.20 001030607.1_23525001_1 - 0.088 10.9 0.0 0.15 10.2 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) DivIC PF04977.13 001030607.1_23525001_1 - 3.2 7.5 5.7 1 9.1 0.1 2.8 3 0 0 3 3 3 0 Septum formation initiator Mto2_bdg PF12808.5 001030607.1_23525001_1 - 3.9 7.7 6.4 11 6.3 0.0 2.9 3 0 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region JAB PF01398.19 001076565.1_16124001_2 - 2.8e-10 40.1 0.0 2e-09 37.3 0.0 2.1 1 1 1 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.4 001076565.1_16124001_2 - 2.6e-08 33.5 0.0 5.1e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain PLU-1 PF08429.9 001031029.1_23529001_3 - 5.3e-94 315.0 9.4 1.4e-89 300.4 3.4 4.0 4 0 0 4 4 4 3 PLU-1-like protein JmjC PF02373.20 001031029.1_23529001_3 - 2.7e-44 150.1 0.7 6.5e-44 148.9 0.7 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.27 001031029.1_23529001_3 - 7.4e-26 89.7 37.4 1.4e-11 43.9 4.1 4.1 4 0 0 4 4 4 3 PHD-finger ARID PF01388.19 001031029.1_23529001_3 - 1e-17 64.4 0.0 2.7e-17 63.1 0.0 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.15 001031029.1_23529001_3 - 2.5e-14 52.8 0.8 5.5e-14 51.7 0.8 1.6 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.14 001031029.1_23529001_3 - 5.9e-13 48.8 12.3 5.9e-13 48.8 12.3 2.9 2 0 0 2 2 2 1 C5HC2 zinc finger PHD_2 PF13831.4 001031029.1_23529001_3 - 0.018 14.4 27.6 0.11 12.0 5.0 4.1 4 0 0 4 4 4 0 PHD-finger Pkinase_Tyr PF07714.15 001031430.1_23529001_2 - 3.8e-87 291.7 0.1 5.6e-87 291.2 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001031430.1_23529001_2 - 8.7e-46 156.3 0.0 1.4e-45 155.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001031430.1_23529001_2 - 6.3e-42 141.4 0.6 8.8e-21 73.6 0.1 2.4 2 0 0 2 2 2 2 SH2 domain Kdo PF06293.12 001031430.1_23529001_2 - 0.0006 19.1 0.1 0.001 18.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family CSD PF00313.20 001031774.2_23523001_2 - 2.2e-16 59.3 0.1 4.2e-16 58.4 0.1 1.5 1 1 0 1 1 1 1 'Cold-shock' DNA-binding domain zf-CCHC PF00098.21 001031774.2_23523001_2 - 4.1e-06 26.5 10.8 0.00012 21.8 3.0 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.4 001031774.2_23523001_2 - 0.23 11.0 9.5 1.2 8.8 1.6 2.5 2 0 0 2 2 2 0 Zinc knuckle DUF2205 PF10224.7 001077559.1_16124001_1 - 2.2e-28 97.9 3.7 3.4e-28 97.3 3.7 1.3 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) IncA PF04156.12 001077559.1_16124001_1 - 0.0019 17.9 1.3 0.0028 17.3 1.3 1.2 1 0 0 1 1 1 1 IncA protein bZIP_1 PF00170.19 001077559.1_16124001_1 - 0.054 13.5 0.8 0.096 12.7 0.8 1.4 1 0 0 1 1 1 0 bZIP transcription factor DASH_Dad4 PF08650.8 001077559.1_16124001_1 - 0.2 11.5 1.7 0.41 10.5 1.7 1.5 1 0 0 1 1 1 0 DASH complex subunit Dad4 DUF972 PF06156.11 001077559.1_16124001_1 - 0.25 11.8 4.3 0.42 11.1 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF972) HALZ PF02183.16 001077559.1_16124001_1 - 0.27 11.3 6.4 0.51 10.5 1.9 2.4 1 1 1 2 2 2 0 Homeobox associated leucine zipper IRF PF00605.15 001040352.1_16123001_1 - 1.2e-42 144.3 0.3 2.3e-42 143.4 0.3 1.5 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor Sec16_C PF12931.5 001031141.1_23529001_2 - 2.8e-05 23.8 0.4 0.00026 20.6 0.4 2.2 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 WD40 PF00400.30 001031141.1_23529001_2 - 0.00043 20.9 1.0 65 4.5 0.0 5.9 6 0 0 6 6 6 0 WD domain, G-beta repeat Prp18 PF02840.13 001031141.1_23529001_2 - 0.0011 19.0 0.2 0.0025 17.8 0.0 1.6 2 0 0 2 2 2 1 Prp18 domain SRA1 PF07304.9 001031141.1_23529001_2 - 0.0012 18.6 0.0 0.0038 16.9 0.0 1.8 1 0 0 1 1 1 1 Steroid receptor RNA activator (SRA1) bZIP_Maf PF03131.15 001079489.1_23524001_3 - 9.7e-33 112.4 11.7 1.7e-32 111.6 11.7 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor DivIC PF04977.13 001079489.1_23524001_3 - 0.00068 19.2 5.9 0.00068 19.2 5.9 2.4 1 1 1 2 2 2 1 Septum formation initiator Prominin PF05478.9 001079489.1_23524001_3 - 0.0019 16.1 1.4 0.0026 15.6 1.4 1.1 1 0 0 1 1 1 1 Prominin bZIP_1 PF00170.19 001079489.1_23524001_3 - 0.0021 18.0 15.4 0.0021 18.0 15.4 2.4 2 1 0 2 2 1 1 bZIP transcription factor DUF4164 PF13747.4 001079489.1_23524001_3 - 0.0072 16.5 2.9 0.013 15.6 2.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4164) DUF1192 PF06698.9 001079489.1_23524001_3 - 0.013 15.4 5.7 0.15 12.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Cnn_1N PF07989.9 001079489.1_23524001_3 - 0.029 14.4 7.9 0.055 13.5 7.9 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 ThrE_2 PF12821.5 001079489.1_23524001_3 - 0.057 13.4 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Threonine/Serine exporter, ThrE HAUS-augmin3 PF14932.4 001079489.1_23524001_3 - 0.062 12.7 5.5 0.089 12.2 5.5 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 GIT_CC PF16559.3 001079489.1_23524001_3 - 0.097 12.6 1.9 0.2 11.6 1.9 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF342 PF03961.11 001079489.1_23524001_3 - 0.11 11.0 4.0 0.15 10.5 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) JIP_LZII PF16471.3 001079489.1_23524001_3 - 0.18 11.8 6.6 0.04 13.9 2.5 1.9 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II APG6 PF04111.10 001079489.1_23524001_3 - 0.19 10.9 5.8 0.29 10.3 5.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Spc24 PF08286.9 001079489.1_23524001_3 - 0.2 11.8 2.3 0.49 10.5 2.3 1.5 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DASH_Spc19 PF08287.9 001079489.1_23524001_3 - 0.87 9.4 11.2 1.5 8.6 11.2 1.2 1 0 0 1 1 1 0 Spc19 Bap31 PF05529.10 001079489.1_23524001_3 - 0.96 8.9 6.2 1.5 8.2 6.2 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like DUF972 PF06156.11 001079489.1_23524001_3 - 1.2 9.6 7.6 0.49 10.9 3.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) IncA PF04156.12 001079489.1_23524001_3 - 2.1 8.0 10.3 5.9 6.5 10.3 1.7 1 1 0 1 1 1 0 IncA protein Mst1_SARAH PF11629.6 001079489.1_23524001_3 - 9.1 6.3 8.3 12 6.0 1.8 2.5 2 1 0 2 2 2 0 C terminal SARAH domain of Mst1 Piwi PF02171.15 001098852.1_23526001_2 - 2.5e-107 358.5 0.0 3.7e-107 357.9 0.0 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.20 001098852.1_23526001_2 - 8.1e-36 122.7 1.4 9.4e-36 122.5 0.2 1.7 2 0 0 2 2 2 1 PAZ domain GAGE PF05831.9 001098852.1_23526001_2 - 2e-10 41.0 2.8 3.7e-10 40.1 2.8 1.5 1 0 0 1 1 1 1 GAGE protein ArgoN PF16486.3 001098852.1_23526001_2 - 5.1e-06 27.1 0.0 1.5e-05 25.6 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.8 001098852.1_23526001_2 - 3.7e-05 23.1 0.0 9.1e-05 21.9 0.0 1.7 1 0 0 1 1 1 1 Argonaute linker 1 domain Calici_coat PF00915.18 001098852.1_23526001_2 - 0.17 10.6 0.0 0.29 9.9 0.0 1.2 1 0 0 1 1 1 0 Calicivirus coat protein CTP_synth_N PF06418.12 001030807.1_23526001_1 - 2.7e-130 433.3 0.2 3.4e-130 432.9 0.2 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.26 001030807.1_23526001_1 - 4.1e-56 189.6 0.0 6.3e-56 189.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.11 001030807.1_23526001_1 - 7.6e-09 35.5 0.0 1.6e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 CbiA PF01656.21 001030807.1_23526001_1 - 0.012 15.6 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Ribosomal_L30_N PF08079.10 001006345.2_23522001_3 - 2e-27 95.1 16.1 3.9e-27 94.2 16.1 1.5 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.18 001006345.2_23522001_3 - 3.1e-26 90.9 1.4 7.6e-26 89.7 1.4 1.7 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e ESCRT-II PF05871.10 001089362.2_16122001_3 - 6.4e-58 194.8 0.4 9e-58 194.3 0.4 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit DUF2555 PF10742.7 001089362.2_16122001_3 - 0.012 15.3 0.1 0.023 14.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2555) IL28A PF15177.4 001128496.1_23522001_1 - 9.9e-58 194.3 7.4 1.1e-57 194.1 7.4 1.0 1 0 0 1 1 1 1 Interleukin-28A EGF PF00008.25 001111226.1_16124001_3 - 0.00011 22.3 5.6 0.00029 20.9 5.6 1.8 1 0 0 1 1 1 1 EGF-like domain DUF3377 PF11857.6 001111226.1_16124001_3 - 0.0084 15.9 0.4 5.6 6.8 0.6 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3377) hEGF PF12661.5 001111226.1_16124001_3 - 0.31 11.6 2.8 1.4 9.6 2.8 2.2 1 1 0 1 1 1 0 Human growth factor-like EGF SNF2_N PF00176.21 001020774.2_16128001_2 - 7e-57 192.6 2.2 1.3e-55 188.4 0.7 2.2 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.29 001020774.2_16128001_2 - 6e-17 61.9 0.0 2.5e-16 59.9 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.3 001020774.2_16128001_2 - 2.2e-05 23.6 0.0 6.9e-05 22.0 0.0 1.8 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.13 001020774.2_16128001_2 - 2.9e-05 24.0 0.0 0.0001 22.2 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HHH_3 PF12836.5 001020774.2_16128001_2 - 0.019 15.1 0.1 0.059 13.5 0.0 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix motif CUE PF02845.14 001020774.2_16128001_2 - 0.022 14.3 0.0 0.29 10.8 0.0 2.5 2 0 0 2 2 2 0 CUE domain Ank_2 PF12796.5 001113615.1_16128001_1 - 5.2e-39 132.6 0.3 2.4e-12 47.1 0.0 3.7 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001113615.1_16128001_1 - 3e-30 104.1 2.7 2.7e-12 46.8 0.0 5.8 1 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.28 001113615.1_16128001_1 - 2.4e-29 100.3 7.1 3.7e-06 27.0 0.0 7.5 6 1 1 7 7 7 5 Ankyrin repeat Ank_5 PF13857.4 001113615.1_16128001_1 - 2.1e-26 91.4 7.4 3.4e-07 30.3 0.0 7.3 2 1 6 8 8 8 6 Ankyrin repeats (many copies) SET PF00856.26 001113615.1_16128001_1 - 1.3e-23 84.0 0.1 5e-23 82.2 0.1 2.1 1 0 0 1 1 1 1 SET domain Ank_3 PF13606.4 001113615.1_16128001_1 - 1.3e-21 74.2 4.5 0.0044 17.3 0.0 7.2 6 0 0 6 6 6 5 Ankyrin repeat Pre-SET PF05033.14 001113615.1_16128001_1 - 3.2e-15 56.6 16.3 3.2e-15 56.6 16.3 2.9 3 0 0 3 3 3 1 Pre-SET motif HARP PF07443.11 001127466.1_16127001_1 - 1.3e-50 168.7 0.1 1.2e-25 88.7 0.1 2.6 2 0 0 2 2 2 2 HepA-related protein (HARP) SNF2_N PF00176.21 001127466.1_16127001_1 - 7.9e-26 90.5 0.0 1.3e-25 89.8 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 001127466.1_16127001_1 - 2e-13 50.5 0.0 5.6e-13 49.1 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 001127466.1_16127001_1 - 1.9e-07 31.1 0.0 1.1e-06 28.6 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 001127466.1_16127001_1 - 0.00091 18.4 0.0 0.0017 17.5 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Flavi_DEAD PF07652.12 001127466.1_16127001_1 - 0.0037 17.1 0.0 0.042 13.7 0.0 2.3 2 0 0 2 2 2 1 Flavivirus DEAD domain SET PF00856.26 001031370.2_23529001_1 - 5.3e-21 75.6 0.0 1.1e-20 74.5 0.0 1.6 1 0 0 1 1 1 1 SET domain Pre-SET PF05033.14 001031370.2_23529001_1 - 6e-16 58.9 4.3 6e-16 58.9 4.3 2.7 3 0 0 3 3 3 1 Pre-SET motif Chromo PF00385.22 001031370.2_23529001_1 - 2.3e-12 46.4 2.7 4.2e-12 45.6 2.7 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Homeobox PF00046.27 131181.1_16123001_1 - 1.5e-20 72.6 6.7 2.8e-20 71.8 6.7 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 131181.1_16123001_1 - 0.061 13.1 1.2 0.095 12.5 0.2 1.9 2 0 0 2 2 2 0 Homeobox KN domain Hist_deacetyl PF00850.17 204156.1_23527001_1 - 7.4e-83 278.4 0.1 1.4e-82 277.5 0.1 1.4 1 0 0 1 1 1 1 Histone deacetylase domain RNA_polI_A34 PF08208.9 204156.1_23527001_1 - 5 7.1 19.6 7.4 6.5 19.6 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Homeobox PF00046.27 001146142.1_23522001_1 - 7.3e-21 73.6 4.8 1.3e-20 72.8 4.8 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001146142.1_23522001_1 - 0.0018 18.0 0.4 0.007 16.1 0.4 2.0 1 1 0 1 1 1 1 Homeobox KN domain Homez PF11569.6 001146142.1_23522001_1 - 0.0055 16.0 0.4 0.012 15.0 0.4 1.5 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez Pro-kuma_activ PF09286.9 001146142.1_23522001_1 - 0.0058 16.8 1.6 0.0058 16.8 0.2 1.7 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain YdaS_antitoxin PF15943.3 001146142.1_23522001_1 - 0.091 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_28 PF13518.4 001146142.1_23522001_2 - 0.038 14.0 1.3 0.72 9.9 0.3 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain F_actin_cap_B PF01115.15 205437.2_23523001_3 - 1.5e-110 368.4 0.0 1.9e-110 368.0 0.0 1.1 1 0 0 1 1 1 1 F-actin capping protein, beta subunit Peptidase_C14 PF00656.20 001167701.1_23527001_1 - 8.5e-43 147.0 0.2 2.9e-42 145.2 0.1 1.8 2 0 0 2 2 2 1 Caspase domain CARD PF00619.19 001167701.1_23527001_1 - 2.1e-19 69.2 0.7 4e-19 68.3 0.7 1.5 1 0 0 1 1 1 1 Caspase recruitment domain CARD_2 PF16739.3 001167701.1_23527001_1 - 6.6e-07 29.1 0.8 1.1e-06 28.4 0.8 1.4 1 0 0 1 1 1 1 Caspase recruitment domain Collagen PF01391.16 001163294.1_16129001_1 - 2.5e-151 491.4 537.3 1.5e-08 34.1 31.4 20.1 1 1 18 19 19 19 18 Collagen triple helix repeat (20 copies) COLFI PF01410.16 001163294.1_16129001_1 - 6.7e-39 133.4 0.0 1.2e-23 83.6 0.0 2.2 1 1 1 2 2 2 2 Fibrillar collagen C-terminal domain Laminin_G_3 PF13385.4 001163294.1_16129001_1 - 0.0005 20.1 0.0 0.00084 19.4 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.22 001163294.1_16129001_1 - 0.0012 19.3 0.0 0.0021 18.5 0.0 1.2 1 0 0 1 1 1 1 Laminin G domain YjcZ PF13990.4 001163294.1_16129001_1 - 0.18 11.0 0.1 0.28 10.4 0.1 1.1 1 0 0 1 1 1 0 YjcZ-like protein Cyclin_N PF00134.21 001167765.1_23525001_1 - 7.5e-13 48.3 5.2 8.2e-12 44.9 0.7 3.0 3 0 0 3 3 3 2 Cyclin, N-terminal domain Cyclin_C_2 PF16899.3 001167765.1_23525001_1 - 1.6e-06 28.3 0.3 4.3e-06 26.9 0.3 1.7 1 1 0 1 1 1 1 Cyclin C-terminal domain TFIIB PF00382.17 001167765.1_23525001_1 - 0.065 13.2 0.1 0.42 10.6 0.0 2.1 2 0 0 2 2 2 0 Transcription factor TFIIB repeat CAP_GLY PF01302.23 001039989.2_16125001_2 - 1.1e-23 82.9 0.9 1.9e-23 82.1 0.9 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.5 001039989.2_16125001_2 - 3.9e-17 61.9 23.6 3.5e-05 23.9 1.7 5.6 3 2 3 6 6 6 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001039989.2_16125001_2 - 1.4e-10 40.8 5.0 2.4e-09 36.8 1.5 2.8 1 1 2 3 3 3 3 Leucine-rich repeat LRR_8 PF13855.4 001039989.2_16125001_2 - 5.4e-09 35.6 22.8 5.4e-05 22.7 3.8 4.9 2 1 1 5 5 5 4 Leucine rich repeat Ubiquitin_2 PF14560.4 001039989.2_16125001_2 - 0.002 18.4 0.0 0.0046 17.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain LRR_1 PF00560.31 001039989.2_16125001_2 - 0.019 15.2 19.3 12 6.7 2.3 8.0 7 1 0 7 7 7 0 Leucine Rich Repeat LRR_6 PF13516.4 001039989.2_16125001_2 - 0.078 12.9 20.7 6.5 7.0 0.1 7.4 8 0 0 8 8 8 0 Leucine Rich repeat hDGE_amylase PF14701.4 001172653.1_16129001_1 - 4.3e-162 540.0 0.0 5.8e-162 539.6 0.0 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.12 001172653.1_16129001_1 - 4.6e-135 450.3 0.0 6.5e-135 449.8 0.0 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.4 001172653.1_16129001_1 - 9e-90 300.8 0.0 1.4e-89 300.1 0.0 1.3 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.4 001172653.1_16129001_1 - 3.2e-19 68.7 0.0 7.1e-19 67.6 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.22 001172653.1_16129001_1 - 0.00021 20.8 0.0 0.00038 20.0 0.0 1.4 1 0 0 1 1 1 1 Alpha amylase, catalytic domain LINES_C PF14695.4 001172653.1_16129001_1 - 0.09 12.1 0.0 0.22 10.8 0.0 1.6 1 0 0 1 1 1 0 Lines C-terminus zf-Tim10_DDP PF02953.13 001271155.1_23522001_3 - 5.1e-15 54.7 3.8 7.6e-15 54.2 3.8 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF2116 PF09889.7 001271155.1_23522001_3 - 0.067 13.1 0.4 0.12 12.2 0.4 1.3 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) CAS_CSE1 PF03378.13 001279695.1_37528001_2 - 1e-175 584.4 1.6 2e-175 583.4 0.6 2.0 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus Cse1 PF08506.8 001279695.1_37528001_2 - 1.4e-167 557.1 5.4 2.8e-167 556.0 5.4 1.6 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.17 001279695.1_37528001_2 - 8e-12 44.8 0.0 3.4e-11 42.7 0.0 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.10 001279695.1_37528001_2 - 0.042 13.8 4.1 0.083 12.8 0.0 3.3 3 1 1 4 4 4 0 Exportin 1-like protein DUF3385 PF11865.6 001279695.1_37528001_2 - 0.26 11.0 1.9 0.84 9.3 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3385) CK_II_beta PF01214.16 001257204.1_23522001_1 - 2.3e-86 288.2 0.0 2.7e-86 287.9 0.0 1.0 1 0 0 1 1 1 1 Casein kinase II regulatory subunit CCDC24 PF15669.3 001257204.1_23522001_1 - 0.13 12.0 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Actin PF00022.17 181601.4_16124001_2 - 8e-151 502.1 0.0 2.1e-150 500.8 0.0 1.6 1 1 0 1 1 1 1 Actin Globin PF00042.20 001167752.2_23522001_1 - 1.6e-22 80.0 0.3 2.6e-22 79.3 0.3 1.3 1 0 0 1 1 1 1 Globin Ras PF00071.20 131309.3_16123001_2 - 1e-48 164.9 0.0 1.3e-48 164.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 131309.3_16123001_2 - 4.7e-30 104.2 0.0 8.2e-30 103.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 131309.3_16123001_2 - 3.6e-10 39.4 0.0 5.2e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 131309.3_16123001_2 - 0.00067 19.6 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.20 131309.3_16123001_2 - 0.0016 18.7 0.1 0.0048 17.1 0.1 1.8 1 1 0 1 1 1 1 RNA helicase GTP_EFTU PF00009.25 131309.3_16123001_2 - 0.0051 16.2 0.2 0.018 14.4 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.4 131309.3_16123001_2 - 0.011 15.4 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.18 131309.3_16123001_2 - 0.011 14.8 0.6 0.38 9.7 0.0 2.6 2 1 1 3 3 3 0 G-protein alpha subunit Gtr1_RagA PF04670.10 131309.3_16123001_2 - 0.021 14.0 0.0 0.03 13.6 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.8 131309.3_16123001_2 - 0.06 12.6 0.0 0.094 12.0 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TsaE PF02367.15 131309.3_16123001_2 - 0.073 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ArgoMid PF16487.3 131309.3_16123001_2 - 0.089 12.9 0.1 0.17 12.0 0.1 1.4 1 0 0 1 1 1 0 Mid domain of argonaute AAA_16 PF13191.4 131309.3_16123001_2 - 0.18 12.0 0.0 0.31 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Guanylate_kin PF00625.19 001007917.2_23526001_3 - 1.9e-60 203.5 0.1 3.2e-60 202.8 0.1 1.3 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 001007917.2_23526001_3 - 1.7e-18 66.6 1.0 1.7e-18 66.6 1.0 1.7 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) SH3_2 PF07653.15 001007917.2_23526001_3 - 6.3e-11 41.7 0.0 1.3e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001007917.2_23526001_3 - 2e-08 33.6 1.0 5.9e-08 32.1 1.0 1.8 1 1 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001007917.2_23526001_3 - 4.6e-05 23.1 0.0 0.00011 21.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PDZ_2 PF13180.4 001007917.2_23526001_3 - 0.00034 20.7 0.3 0.0012 19.0 0.1 1.9 2 0 0 2 2 2 1 PDZ domain DUF258 PF03193.14 001007917.2_23526001_3 - 0.0039 17.0 0.0 0.016 15.0 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Tricorn_PDZ PF14685.4 001007917.2_23526001_3 - 0.01 15.7 0.5 0.5 10.3 0.2 3.0 3 1 0 3 3 3 0 Tricorn protease PDZ domain MMR_HSR1 PF01926.21 001007917.2_23526001_3 - 0.12 12.4 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase CTP_transf_3 PF02348.17 001040252.2_16124001_3 - 6.1e-47 160.2 0.0 9.3e-47 159.6 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.5 001040252.2_16124001_3 - 3.9e-05 23.9 0.0 0.00011 22.5 0.0 1.7 2 1 0 2 2 2 1 MobA-like NTP transferase domain Hydrolase_3 PF08282.10 001040252.2_16124001_3 - 0.12 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Homeobox PF00046.27 001276354.1_23525001_1 - 1.9e-20 72.3 5.3 3.7e-20 71.4 5.3 1.5 1 0 0 1 1 1 1 Homeobox domain DUF2986 PF11661.6 001276354.1_23525001_1 - 0.012 15.9 0.5 0.035 14.5 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2986) Homeobox_KN PF05920.9 001276354.1_23525001_1 - 0.15 11.9 1.9 0.21 11.4 0.3 2.1 2 0 0 2 2 2 0 Homeobox KN domain Cbl_N2 PF02761.12 001276354.1_23525001_2 - 0.023 15.3 0.8 0.048 14.2 0.2 1.8 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain Peptidase_C54 PF03416.17 001271986.1_23525001_2 - 5.3e-99 330.8 0.0 6.7e-99 330.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 CTP_transf_3 PF02348.17 001258409.1_16123001_1 - 2.3e-41 142.0 0.0 3.2e-41 141.5 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.5 001258409.1_16123001_1 - 1.6e-05 25.2 0.0 2.6e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Baculo_LEF-11 PF06385.10 001258409.1_16123001_1 - 0.1 13.0 0.1 0.23 11.8 0.1 1.6 1 0 0 1 1 1 0 Baculovirus LEF-11 protein IspD PF01128.17 001258409.1_16123001_1 - 0.14 11.7 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Longin PF13774.4 001031266.3_23526001_2 - 5.9e-25 87.0 0.2 9.7e-25 86.3 0.2 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.19 001031266.3_23526001_2 - 1.1e-14 53.9 0.5 1.1e-14 53.9 0.5 1.8 2 0 0 2 2 2 1 Synaptobrevin Sec20 PF03908.11 001031266.3_23526001_2 - 2.5 7.9 7.9 0.13 12.1 1.3 2.3 3 1 0 3 3 3 0 Sec20 Pkinase PF00069.23 001256634.1_16129001_3 - 1.2e-62 211.6 0.4 7.1e-62 209.0 0.0 2.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 001256634.1_16129001_3 - 1.1e-29 103.4 0.4 3.2e-29 101.9 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Rho_Binding PF08912.9 001256634.1_16129001_3 - 7.6e-22 77.8 10.8 7.6e-22 77.8 10.8 12.7 4 3 6 11 11 7 1 Rho Binding PH PF00169.27 001256634.1_16129001_3 - 1.7e-05 25.1 0.1 0.0012 19.1 0.0 2.9 2 0 0 2 2 2 1 PH domain C1_1 PF00130.20 001256634.1_16129001_3 - 6.5e-05 22.6 5.6 0.00017 21.3 5.6 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) GAS PF13851.4 001256634.1_16129001_3 - 0.0016 17.7 21.3 0.0016 17.7 21.3 6.6 1 1 5 7 7 5 1 Growth-arrest specific micro-tubule binding Filament PF00038.19 001256634.1_16129001_3 - 0.002 17.6 140.6 0.11 11.9 9.6 4.4 2 1 2 4 4 4 4 Intermediate filament protein APH PF01636.21 001256634.1_16129001_3 - 0.0022 17.8 0.2 0.041 13.7 0.1 2.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family HR1 PF02185.14 001256634.1_16129001_3 - 0.0064 16.4 14.4 0.0064 16.4 14.4 10.8 5 4 3 8 8 3 2 Hr1 repeat Pkinase_C PF00433.22 001256634.1_16129001_3 - 0.025 15.1 1.3 0.08 13.5 1.3 2.0 1 0 0 1 1 1 0 Protein kinase C terminal domain Spc7 PF08317.9 001256634.1_16129001_3 - 4.2 6.0 154.2 0.0035 16.1 23.6 6.7 1 1 3 6 6 6 0 Spc7 kinetochore protein DUF3584 PF12128.6 001256634.1_16129001_3 - 7.5 3.8 143.3 0.14 9.5 26.9 4.1 1 1 3 4 4 4 0 Protein of unknown function (DUF3584) Ribosomal_L7Ae PF01248.24 001277911.1_23522001_3 - 1.7e-29 101.3 1.8 2.4e-29 100.8 1.8 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Homeobox PF00046.27 204104.2_23523001_2 - 4e-24 84.1 4.5 6.9e-24 83.3 4.5 1.4 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 204104.2_23523001_2 - 3.6e-10 39.2 1.4 7.2e-10 38.2 1.4 1.5 1 0 0 1 1 1 1 OAR domain 3HCDH_N PF02737.16 001105276.1_16126001_2 - 1.1e-53 181.7 0.6 2.3e-53 180.6 0.6 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.18 001105276.1_16126001_2 - 1.7e-40 138.8 0.5 2.7e-40 138.1 0.5 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.20 001105276.1_16126001_2 - 5.1e-30 103.8 0.0 2.6e-23 82.3 0.1 2.7 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.3 001105276.1_16126001_2 - 2.1e-24 86.5 0.1 3.4e-24 85.8 0.1 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF766 PF05571.10 200482.2_16124001_1 - 2.8e-115 384.8 12.8 2.8e-115 384.8 12.8 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF766) Ammonium_transp PF00909.19 212845.1_16124001_1 - 1.6e-77 260.7 18.6 2.1e-77 260.3 18.6 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family AzlD PF05437.10 212845.1_16124001_1 - 0.0051 16.8 7.6 0.085 12.9 0.3 4.2 2 1 2 4 4 4 1 Branched-chain amino acid transport protein (AzlD) UPF0197 PF05251.10 212845.1_16124001_1 - 0.88 9.5 7.0 1 9.3 2.9 3.1 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0197) Astacin PF01400.22 001045174.2_16123001_1 - 1.3e-62 210.7 0.2 1.6e-62 210.4 0.2 1.1 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.22 001045174.2_16123001_1 - 0.086 12.6 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Matrixin Homeobox PF00046.27 001293098.1_23526001_1 - 4.4e-22 77.5 6.6 4.4e-22 77.5 6.6 2.0 3 0 0 3 3 3 1 Homeobox domain OAR PF03826.15 001293098.1_23526001_1 - 3e-07 29.9 0.1 7e-07 28.7 0.1 1.7 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 001293098.1_23526001_1 - 0.00098 18.8 0.1 0.0029 17.3 0.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain zf-C4 PF00105.16 001113484.1_16124001_1 - 5.5e-31 106.7 17.5 9.4e-31 106.0 17.5 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001113484.1_16124001_1 - 5.9e-29 101.0 0.0 1.1e-28 100.1 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor LIM PF00412.20 205358.1_23523001_1 - 7.6e-34 115.6 27.9 9.2e-17 60.9 8.6 2.4 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 205358.1_23523001_1 - 8.3e-18 63.8 2.3 1.9e-17 62.7 2.3 1.7 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 205358.1_23523001_1 - 0.00016 21.4 0.0 0.00034 20.3 0.0 1.5 1 0 0 1 1 1 1 Homeobox KN domain PNISR PF15996.3 205358.1_23523001_1 - 0.066 13.2 5.0 1.2 9.2 0.3 2.1 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Spectrin PF00435.19 205299.2_23529001_1 - 5.9e-186 605.1 293.7 4.7e-18 65.5 5.3 25.8 24 2 1 25 25 25 22 Spectrin repeat CH PF00307.29 205299.2_23529001_1 - 5.9e-46 155.0 6.8 3.1e-21 75.5 0.0 5.0 3 0 0 3 3 3 2 Calponin homology (CH) domain EF-hand_3 PF09069.9 205299.2_23529001_1 - 2.1e-39 133.7 1.8 1.6e-38 130.9 0.0 3.7 3 0 0 3 3 3 1 EF-hand EF-hand_2 PF09068.9 205299.2_23529001_1 - 2.4e-39 134.1 1.4 2.4e-39 134.1 1.4 3.5 2 0 0 2 2 2 1 EF hand ZZ PF00569.15 205299.2_23529001_1 - 7.7e-19 67.1 4.2 1.6e-18 66.1 4.2 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type WW PF00397.24 205299.2_23529001_1 - 6e-09 35.6 2.1 2.1e-08 33.8 2.1 2.1 1 0 0 1 1 1 1 WW domain CAMSAP_CH PF11971.6 205299.2_23529001_1 - 2e-06 27.4 0.0 0.0023 17.6 0.0 3.8 3 0 0 3 3 3 1 CAMSAP CH domain Katanin_con80 PF13925.4 001030559.2_23527001_1 - 4.2e-55 186.0 1.2 6.7e-55 185.3 1.2 1.3 1 0 0 1 1 1 1 con80 domain of Katanin WD40 PF00400.30 001030559.2_23527001_1 - 2e-44 148.6 14.2 9.2e-11 42.0 0.3 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001030559.2_23527001_1 - 6.9e-18 64.6 0.1 7e-05 22.9 0.0 5.0 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001030559.2_23527001_1 - 3.4e-06 26.9 0.0 0.00095 19.0 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 001030559.2_23527001_1 - 0.013 14.4 0.0 0.2 10.4 0.0 2.6 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.9 001030559.2_23527001_1 - 0.019 13.6 0.1 2.9 6.4 0.0 3.4 2 2 2 4 4 4 0 Nup133 N terminal like Ig_3 PF13927.4 001160320.3_23529001_1 - 8e-74 244.1 0.0 1.2e-13 51.3 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 001160320.3_23529001_1 - 1.1e-70 233.6 0.0 5.5e-13 48.7 0.0 6.4 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_2 PF13895.4 001160320.3_23529001_1 - 1.9e-49 165.8 0.0 2.8e-09 37.1 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 001160320.3_23529001_1 - 2.1e-42 143.0 0.0 7.3e-09 35.6 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin domain fn3 PF00041.19 001160320.3_23529001_1 - 6.1e-36 122.5 11.1 2.2e-11 43.8 0.1 4.6 4 0 0 4 4 4 4 Fibronectin type III domain Bravo_FIGEY PF13882.4 001160320.3_23529001_1 - 3.1e-26 92.4 5.9 6.9e-26 91.3 5.9 1.6 1 0 0 1 1 1 1 Bravo-like intracellular region V-set PF07686.15 001160320.3_23529001_1 - 2.3e-11 43.7 8.2 0.0044 17.0 0.0 8.0 8 3 1 9 9 9 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 001160320.3_23529001_1 - 1.9e-09 37.3 0.1 0.29 11.1 0.0 5.8 6 0 0 6 6 5 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 001160320.3_23529001_1 - 2.3e-07 31.0 0.0 0.047 14.0 0.0 4.7 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 001160320.3_23529001_1 - 0.004 17.0 0.2 20 5.2 0.0 3.7 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain BiPBP_C PF06832.10 001160320.3_23529001_1 - 0.017 15.0 0.0 0.48 10.4 0.0 3.2 4 0 0 4 4 4 0 Penicillin-Binding Protein C-terminus Family Pkinase PF00069.23 204377.3_23524001_3 - 3.3e-27 95.4 0.0 4.2e-27 95.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 204377.3_23524001_3 - 9.6e-17 61.0 0.0 1.2e-16 60.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 204377.3_23524001_3 - 0.00048 20.0 0.0 0.0019 18.1 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.9 204377.3_23524001_3 - 0.06 12.2 0.1 0.098 11.5 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.12 204377.3_23524001_3 - 0.14 11.4 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Roc PF08477.11 001030780.2_23527001_3 - 3.7e-14 52.8 0.0 9.2e-14 51.6 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001030780.2_23527001_3 - 9.9e-12 44.6 0.0 2.3e-11 43.4 0.0 1.5 1 1 0 1 1 1 1 Ras family MMR_HSR1 PF01926.21 001030780.2_23527001_3 - 0.00015 21.7 0.0 0.00023 21.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001030780.2_23527001_3 - 0.00065 19.0 0.0 0.001 18.3 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.19 001030780.2_23527001_3 - 0.0032 16.8 0.0 0.0061 15.9 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 001030780.2_23527001_3 - 0.012 15.4 0.1 0.026 14.3 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_16 PF13191.4 001030780.2_23527001_3 - 0.027 14.7 0.0 0.05 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain IIGP PF05049.11 001030780.2_23527001_3 - 0.1 11.5 0.1 0.17 10.8 0.1 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Ig_3 PF13927.4 001004709.4_23529001_1 - 6.9e-74 244.3 0.0 1.2e-13 51.4 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 001004709.4_23529001_1 - 1e-70 233.7 0.0 5.4e-13 48.7 0.0 6.5 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_2 PF13895.4 001004709.4_23529001_1 - 1.7e-49 166.0 0.0 2.8e-09 37.1 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 001004709.4_23529001_1 - 1.9e-42 143.2 0.0 7.2e-09 35.6 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin domain fn3 PF00041.19 001004709.4_23529001_1 - 1.6e-27 95.5 11.2 2.1e-11 43.8 0.1 3.8 4 0 0 4 4 3 3 Fibronectin type III domain Bravo_FIGEY PF13882.4 001004709.4_23529001_1 - 3.1e-26 92.4 5.9 6.8e-26 91.3 5.9 1.6 1 0 0 1 1 1 1 Bravo-like intracellular region V-set PF07686.15 001004709.4_23529001_1 - 2.2e-11 43.7 8.2 0.0044 17.0 0.0 8.0 8 3 1 9 9 9 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 001004709.4_23529001_1 - 1.3e-09 37.8 0.1 0.29 11.1 0.0 6.1 6 0 0 6 6 5 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 001004709.4_23529001_1 - 2.1e-07 31.1 0.0 0.047 14.0 0.0 4.7 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain TMEM154 PF15102.4 001004709.4_23529001_1 - 8.6e-05 22.3 3.8 0.00025 20.9 3.8 1.7 1 1 0 1 1 1 1 TMEM154 protein family Izumo-Ig PF16706.3 001004709.4_23529001_1 - 0.0025 17.7 0.1 19 5.2 0.0 3.7 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain BiPBP_C PF06832.10 001004709.4_23529001_1 - 0.0065 16.4 0.0 0.47 10.4 0.0 3.8 5 0 0 5 5 5 1 Penicillin-Binding Protein C-terminus Family MGC-24 PF05283.9 001004709.4_23529001_1 - 0.73 10.1 7.0 3.2 8.1 7.0 2.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Ribosomal_L37ae PF01780.17 001079493.2_23521001_3 - 3.2e-47 158.4 11.4 4e-47 158.1 11.4 1.1 1 0 0 1 1 1 1 Ribosomal L37ae protein family Rsm1 PF08600.8 001079493.2_23521001_3 - 0.018 15.0 0.3 0.024 14.7 0.3 1.3 1 0 0 1 1 1 0 Rsm1-like Zn_Tnp_IS1595 PF12760.5 001079493.2_23521001_3 - 0.075 12.9 1.5 0.12 12.2 1.5 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-C4_ClpX PF06689.11 001079493.2_23521001_3 - 0.19 11.5 4.0 0.59 9.9 4.0 1.9 1 1 0 1 1 1 0 ClpX C4-type zinc finger LRR_8 PF13855.4 001302224.1_16129001_1 - 6.3e-22 77.0 11.9 1.7e-14 53.1 3.7 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_5 PF13306.4 001302224.1_16129001_1 - 4.2e-08 33.1 0.3 1.5e-07 31.3 0.3 1.9 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001302224.1_16129001_1 - 5.3e-08 32.9 10.7 0.0014 18.8 3.0 3.0 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) I-set PF07679.14 001302224.1_16129001_1 - 6.1e-07 29.3 0.0 1.8e-06 27.8 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001302224.1_16129001_1 - 6.3e-07 29.8 0.0 2.7e-06 27.7 0.0 2.2 2 0 0 2 2 1 1 Immunoglobulin domain Ig_2 PF13895.4 001302224.1_16129001_1 - 4.6e-06 26.8 0.0 2e-05 24.7 0.0 2.2 1 1 0 1 1 1 1 Immunoglobulin domain GPS PF01825.19 001302224.1_16129001_1 - 5.7e-06 26.8 0.4 5.7e-06 26.8 0.4 2.9 3 0 0 3 3 2 1 GPCR proteolysis site, GPS, motif HRM PF02793.20 001302224.1_16129001_1 - 9.6e-05 22.5 0.7 0.00029 20.9 0.7 1.8 1 0 0 1 1 1 1 Hormone receptor domain ig PF00047.23 001302224.1_16129001_1 - 0.00026 21.0 0.0 0.00063 19.7 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Adaptin_N PF01602.18 001302224.1_16129001_1 - 0.025 13.0 0.2 0.038 12.4 0.2 1.2 1 0 0 1 1 1 0 Adaptin N terminal region LRR_1 PF00560.31 001302224.1_16129001_1 - 0.04 14.2 11.8 6.5 7.5 0.0 5.4 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_9 PF14580.4 001302224.1_16129001_1 - 0.043 13.2 0.3 0.098 12.0 0.3 1.6 1 0 0 1 1 1 0 Leucine-rich repeat Semialdhyde_dh PF01118.22 001302224.1_16129001_1 - 0.071 13.4 0.1 0.24 11.7 0.0 1.9 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain LRRCT PF01463.22 001302224.1_16129001_1 - 0.11 12.9 0.1 0.73 10.4 0.0 2.5 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain PalH PF08733.8 001302224.1_16129001_1 - 0.34 9.7 7.1 0.7 8.7 7.1 1.4 1 0 0 1 1 1 0 PalH/RIM21 Hyccin PF09790.7 001030983.2_23527001_2 - 1.1e-127 425.4 0.5 1.9e-127 424.7 0.5 1.4 1 0 0 1 1 1 1 Hyccin CEP63 PF17045.3 001168007.1_23526001_1 - 2.2e-110 368.7 56.8 2.2e-110 368.7 56.8 4.9 3 1 1 5 5 5 1 Centrosomal protein of 63 kDa Pkinase_Tyr PF07714.15 001301356.1_16127001_1 - 3.7e-92 308.2 0.0 5.1e-92 307.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001301356.1_16127001_1 - 1.8e-45 155.3 0.0 2.6e-45 154.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 001301356.1_16127001_1 - 1.2e-14 54.0 0.0 2e-08 34.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 001301356.1_16127001_1 - 2.3e-14 53.6 1.4 1.1e-09 38.6 0.3 2.5 2 0 0 2 2 2 2 Immunoglobulin domain TPKR_C2 PF16920.3 001301356.1_16127001_1 - 7.1e-14 51.5 6.6 2.8e-13 49.6 6.6 2.1 1 0 0 1 1 1 1 Tyrosine-protein kinase receptor C2 Ig-like domain ig PF00047.23 001301356.1_16127001_1 - 1.9e-10 40.6 0.4 1.3e-07 31.6 0.2 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001301356.1_16127001_1 - 8.3e-10 38.8 0.3 2.5e-05 24.4 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain LRR_8 PF13855.4 001301356.1_16127001_1 - 7.1e-08 32.0 2.5 1.6e-07 30.8 2.5 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_5 PF13306.4 001301356.1_16127001_1 - 2.4e-07 30.6 1.0 4.9e-07 29.6 1.0 1.4 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) C2-set_2 PF08205.10 001301356.1_16127001_1 - 2.8e-05 24.0 0.6 0.018 14.9 0.2 2.8 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain CFC PF09443.8 001301356.1_16127001_1 - 0.05 13.3 0.9 0.14 11.9 0.9 1.7 1 0 0 1 1 1 0 Cripto_Frl-1_Cryptic (CFC) ERG2_Sigma1R PF04622.10 001270557.3_23524001_3 - 4.7e-67 225.3 0.2 6.4e-67 224.8 0.2 1.1 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein WD40 PF00400.30 001039331.2_23524001_3 - 4.3e-34 115.8 12.2 5.3e-08 33.3 0.0 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat Prp19 PF08606.9 001039331.2_23524001_3 - 3.8e-33 113.1 2.6 3.8e-33 113.1 2.6 1.7 2 0 0 2 2 2 1 Prp19/Pso4-like ANAPC4_WD40 PF12894.5 001039331.2_23524001_3 - 7.8e-14 51.6 0.0 0.0035 17.5 0.0 5.0 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain U-box PF04564.13 001039331.2_23524001_3 - 4.3e-08 33.1 0.0 9.3e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 U-box domain Nup160 PF11715.6 001039331.2_23524001_3 - 0.00018 20.2 1.2 0.025 13.1 0.2 2.2 1 1 0 2 2 2 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.3 001039331.2_23524001_3 - 0.00022 20.2 1.2 0.63 8.8 0.1 3.5 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.14 001039331.2_23524001_3 - 0.0014 17.2 0.0 0.84 8.0 0.0 2.3 2 0 0 2 2 2 2 Cytochrome D1 heme domain zf-Nse PF11789.6 001039331.2_23524001_3 - 0.0015 18.2 0.0 0.0039 16.8 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit eIF2A PF08662.9 001039331.2_23524001_3 - 0.0027 17.5 0.0 1.9 8.2 0.0 2.6 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A DUF1830 PF08865.9 001039331.2_23524001_3 - 0.071 13.0 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1830) Nucleoporin_N PF08801.9 001039331.2_23524001_3 - 0.087 11.4 0.2 1.5 7.3 0.0 2.1 1 1 0 2 2 2 0 Nup133 N terminal like Peptidase_M10 PF00413.22 001317753.1_16124001_2 - 8.5e-36 123.0 0.0 1.7e-35 122.1 0.0 1.5 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 001317753.1_16124001_2 - 7.4e-20 70.5 15.8 3.9e-07 29.8 1.4 4.8 4 1 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 001317753.1_16124001_2 - 7e-08 32.4 0.3 7.9e-07 29.1 0.3 2.4 1 1 0 1 1 1 1 Putative peptidoglycan binding domain Metallopep PF12044.6 001317753.1_16124001_2 - 0.007 14.9 0.0 0.012 14.1 0.0 1.3 1 0 0 1 1 1 1 Putative peptidase family Peptidase_M54 PF07998.9 001317753.1_16124001_2 - 0.036 13.9 0.0 0.07 13.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M54 DUF4953 PF16313.3 001317753.1_16124001_2 - 0.04 13.0 0.0 0.073 12.1 0.0 1.4 1 0 0 1 1 1 0 Met-zincin Reprolysin_3 PF13582.4 001317753.1_16124001_2 - 0.13 12.7 0.6 0.28 11.6 0.6 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Histone PF00125.22 001101037.2_23521001_1 - 3e-39 134.3 0.0 3.3e-39 134.2 0.0 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.4 001101037.2_23521001_1 - 0.0013 18.7 0.0 0.002 18.1 0.0 1.3 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.21 001101037.2_23521001_1 - 0.013 15.7 0.0 0.021 15.0 0.0 1.3 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.13 001101037.2_23521001_1 - 0.11 12.4 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit GKAP PF03359.11 001202455.1_16126001_1 - 4.1e-138 460.5 0.1 4.1e-138 460.5 0.1 3.0 3 1 0 3 3 3 1 Guanylate-kinase-associated protein (GKAP) protein CLASP_N PF12348.6 207072.2_16129001_2 - 5.3e-41 140.5 6.1 2.6e-38 131.7 0.0 4.4 4 1 0 4 4 4 2 CLASP N terminal HEAT PF02985.20 207072.2_16129001_2 - 4.9e-06 26.2 11.7 0.033 14.3 0.0 7.4 8 0 0 8 8 7 1 HEAT repeat HEAT_2 PF13646.4 207072.2_16129001_2 - 1.3e-05 25.4 5.3 0.03 14.6 0.0 5.7 3 2 4 7 7 7 3 HEAT repeats MMS19_C PF12460.6 207072.2_16129001_2 - 2e-05 23.8 0.2 0.047 12.7 0.0 2.8 2 0 0 2 2 2 2 RNAPII transcription regulator C-terminal RTP1_C1 PF10363.7 207072.2_16129001_2 - 4.1e-05 23.6 0.2 0.12 12.4 0.0 3.8 2 1 1 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 IFRD PF05004.11 207072.2_16129001_2 - 0.00019 20.5 13.7 0.0035 16.4 0.6 5.5 5 1 1 6 6 6 2 Interferon-related developmental regulator (IFRD) ParcG PF10274.7 207072.2_16129001_2 - 0.0002 21.4 0.0 0.0011 19.0 0.0 2.2 2 0 0 2 2 2 1 Parkin co-regulated protein HEAT_EZ PF13513.4 207072.2_16129001_2 - 0.0003 21.0 0.2 0.1 12.9 0.0 4.4 4 0 0 4 4 4 1 HEAT-like repeat Cnd1 PF12717.5 207072.2_16129001_2 - 0.00073 19.4 1.1 0.026 14.4 0.8 3.1 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.18 207072.2_16129001_2 - 0.0054 15.2 1.6 2.4 6.4 0.1 4.0 4 1 0 5 5 5 1 Adaptin N terminal region MMS19_N PF14500.4 207072.2_16129001_2 - 0.014 14.8 0.5 5.7 6.3 0.0 3.6 3 2 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II TAN PF11640.6 207072.2_16129001_2 - 0.13 12.3 4.9 0.52 10.3 0.0 3.7 4 1 0 4 4 4 0 Telomere-length maintenance and DNA damage repair Homeobox PF00046.27 204595.2_23525001_3 - 6.6e-21 73.8 8.1 1.2e-20 72.9 8.1 1.4 1 0 0 1 1 1 1 Homeobox domain HLH PF00010.24 204966.2_23522001_1 - 2e-18 66.0 0.6 2e-18 66.0 0.6 1.6 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain WWE PF02825.18 199854.2_16125001_3 - 2.9e-15 56.4 1.9 4.9e-15 55.7 1.9 1.4 1 0 0 1 1 1 1 WWE domain zf-C3HC4_3 PF13920.4 199854.2_16125001_3 - 1.1e-05 25.0 12.6 2.6e-05 23.8 12.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 199854.2_16125001_3 - 0.00031 20.8 15.8 0.00031 20.8 15.8 1.9 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.4 199854.2_16125001_3 - 0.00067 19.5 13.3 0.0015 18.3 13.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 199854.2_16125001_3 - 0.0025 17.8 12.1 0.0067 16.4 12.1 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 199854.2_16125001_3 - 0.0095 15.7 13.6 0.024 14.4 13.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 199854.2_16125001_3 - 0.014 15.1 12.3 0.045 13.5 12.3 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Nop14 PF04147.10 199854.2_16125001_3 - 0.018 13.2 0.9 0.023 12.8 0.9 1.1 1 0 0 1 1 1 0 Nop14-like family zf-RING_5 PF14634.4 199854.2_16125001_3 - 0.14 12.0 13.0 0.38 10.6 13.0 1.8 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.4 199854.2_16125001_3 - 0.2 11.4 19.3 0.026 14.2 14.1 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) VEFS-Box PF09733.7 001082824.2_16126001_3 - 8e-51 171.3 0.7 1.4e-50 170.5 0.7 1.3 1 0 0 1 1 1 1 VEFS-Box of polycomb protein DUF4074 PF13293.4 001349760.1_23523001_1 - 9.1e-37 125.0 8.6 9.1e-37 125.0 8.6 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4074) Homeobox PF00046.27 001349760.1_23523001_1 - 2e-21 75.4 4.9 4e-21 74.5 4.9 1.5 1 0 0 1 1 1 1 Homeobox domain NAM-associated PF14303.4 001349760.1_23523001_1 - 0.026 15.1 4.8 0.05 14.1 4.8 1.6 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain CDC27 PF09507.8 001349760.1_23523001_1 - 1.5 8.0 11.3 2.3 7.4 11.3 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Vinculin PF01044.17 001159372.1_16126001_1 - 2.2e-296 986.0 35.6 3.5e-217 723.9 21.9 3.1 1 1 2 3 3 3 3 Vinculin family Rotamase PF00639.19 001159372.1_16126001_1 - 0.31 11.9 9.3 1.7 9.5 0.1 5.0 4 1 1 5 5 5 0 PPIC-type PPIASE domain DivIC PF04977.13 001159372.1_16126001_1 - 0.38 10.4 3.2 0.39 10.4 0.8 2.3 2 0 0 2 2 2 0 Septum formation initiator SAWADEE PF16719.3 001159372.1_16126001_1 - 0.5 10.2 2.8 0.89 9.4 0.1 2.7 3 0 0 3 3 3 0 SAWADEE domain NGF PF00243.16 001351718.1_16123001_3 - 3.4e-45 152.8 3.3 5e-45 152.2 3.3 1.3 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.3 001351718.1_16123001_3 - 0.029 14.7 0.2 0.06 13.7 0.2 1.5 1 0 0 1 1 1 0 Spaetzle ATP-gua_Ptrans PF00217.17 204182.2_23523001_1 - 1.4e-95 319.4 0.0 1.7e-95 319.1 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 204182.2_23523001_1 - 1.6e-30 105.2 0.0 2.4e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain V-set PF07686.15 001326470.1_16122001_2 - 1.7e-05 24.8 0.2 3.9e-05 23.6 0.2 1.6 1 1 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 001326470.1_16122001_2 - 8.6e-05 22.4 0.0 0.00018 21.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001326470.1_16122001_2 - 0.0001 22.7 0.1 0.00019 21.8 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001326470.1_16122001_2 - 0.00012 22.0 0.2 0.00051 20.0 0.2 1.9 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001326470.1_16122001_2 - 0.00067 19.8 0.3 0.0017 18.5 0.3 1.6 1 1 0 1 1 1 1 Immunoglobulin domain Met_10 PF02475.14 001145583.1_16124001_3 - 1.4e-65 220.6 0.0 2.1e-65 220.0 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.8 001145583.1_16124001_3 - 1.3e-05 24.9 0.0 3.1e-05 23.7 0.0 1.7 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.11 001145583.1_16124001_3 - 0.00061 19.1 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MethyltransfD12 PF02086.13 001145583.1_16124001_3 - 0.0012 18.5 0.0 0.0022 17.6 0.0 1.3 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase Cons_hypoth95 PF03602.13 001145583.1_16124001_3 - 0.0031 17.0 0.0 0.0074 15.8 0.0 1.6 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.12 001145583.1_16124001_3 - 0.014 14.8 0.0 0.059 12.8 0.0 1.9 1 1 1 2 2 2 0 Methyltransferase small domain TRM PF02005.14 001145583.1_16124001_3 - 0.017 14.2 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_25 PF13649.4 001145583.1_16124001_3 - 0.056 14.0 0.0 0.15 12.7 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.5 001145583.1_16124001_3 - 0.13 12.0 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Homeobox PF00046.27 001030987.2_23523001_1 - 4.2e-21 74.4 8.8 7.4e-21 73.6 8.8 1.4 1 0 0 1 1 1 1 Homeobox domain CLASP_N PF12348.6 001328259.1_16129001_3 - 1.1e-51 175.4 3.2 3.6e-38 131.3 0.0 5.2 5 1 0 5 5 5 2 CLASP N terminal HEAT PF02985.20 001328259.1_16129001_3 - 7.1e-13 47.5 13.6 0.00059 19.7 0.0 9.1 10 0 0 10 10 9 2 HEAT repeat HEAT_2 PF13646.4 001328259.1_16129001_3 - 3.1e-10 40.2 5.7 0.042 14.1 0.0 7.2 5 2 5 10 10 10 5 HEAT repeats Cnd1 PF12717.5 001328259.1_16129001_3 - 2.3e-09 37.3 0.8 0.035 14.0 0.8 5.0 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 001328259.1_16129001_3 - 4.6e-09 36.4 1.8 0.14 12.5 0.0 6.1 6 0 0 6 6 6 2 HEAT-like repeat MMS19_C PF12460.6 001328259.1_16129001_3 - 3.2e-05 23.1 0.2 0.062 12.3 0.0 2.8 2 0 0 2 2 2 2 RNAPII transcription regulator C-terminal Adaptin_N PF01602.18 001328259.1_16129001_3 - 6.5e-05 21.5 0.7 3.3 6.0 0.1 4.9 4 1 0 5 5 5 2 Adaptin N terminal region RTP1_C1 PF10363.7 001328259.1_16129001_3 - 7.1e-05 22.8 0.2 0.15 12.1 0.0 4.0 2 1 1 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 ParcG PF10274.7 001328259.1_16129001_3 - 0.0003 20.8 0.0 0.0014 18.6 0.0 2.2 2 0 0 2 2 2 1 Parkin co-regulated protein IFRD PF05004.11 001328259.1_16129001_3 - 0.00055 19.0 13.5 0.0046 16.0 0.6 5.5 5 1 0 6 6 6 1 Interferon-related developmental regulator (IFRD) TAN PF11640.6 001328259.1_16129001_3 - 0.015 15.3 0.7 0.67 10.0 0.0 3.5 2 1 0 2 2 2 0 Telomere-length maintenance and DNA damage repair Arm PF00514.21 001328259.1_16129001_3 - 0.021 14.8 0.2 0.94 9.5 0.0 3.6 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat MMS19_N PF14500.4 001328259.1_16129001_3 - 0.023 14.1 0.2 7.7 5.8 0.0 3.5 3 1 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II Dopey_N PF04118.12 001328259.1_16129001_3 - 0.056 12.5 1.4 0.91 8.5 0.1 3.0 4 0 0 4 4 4 0 Dopey, N-terminal Nipped-B_C PF12830.5 001328259.1_16129001_3 - 0.13 12.1 0.3 5.5 6.7 0.0 3.5 3 1 0 3 3 3 0 Sister chromatid cohesion C-terminus PLU-1 PF08429.9 001002166.2_16129001_1 - 1.4e-93 313.6 8.9 1.4e-89 300.5 6.6 3.1 4 0 0 4 4 4 2 PLU-1-like protein JmjC PF02373.20 001002166.2_16129001_1 - 1.9e-43 147.4 0.6 4.2e-43 146.3 0.6 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.27 001002166.2_16129001_1 - 1e-21 76.4 50.0 2.1e-12 46.6 3.8 4.5 5 0 0 5 5 5 3 PHD-finger ARID PF01388.19 001002166.2_16129001_1 - 6.3e-17 61.9 0.0 1.7e-16 60.5 0.0 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.15 001002166.2_16129001_1 - 4e-15 55.3 1.5 8e-15 54.4 1.5 1.5 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.14 001002166.2_16129001_1 - 4.9e-14 52.3 11.4 4.9e-14 52.3 11.4 3.2 3 0 0 3 3 3 1 C5HC2 zinc finger TIMP PF00965.15 205487.2_23522001_3 - 8.2e-64 214.6 8.4 1.1e-63 214.2 8.4 1.2 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase SelP_N PF04592.12 001031609.2_23525001_1 - 4.5e-97 323.9 12.7 6.4e-97 323.4 12.7 1.2 1 0 0 1 1 1 1 Selenoprotein P, N terminal region SelP_C PF04593.12 001031609.2_23525001_1 - 0.0015 18.4 0.5 0.0028 17.5 0.5 1.5 1 0 0 1 1 1 1 Selenoprotein P, C terminal region Zip PF02535.20 001031609.2_23525001_1 - 0.82 8.7 8.5 1.3 8.0 8.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Cbl_N PF02262.14 001007330.1_16129001_1 - 3.9e-56 188.3 0.6 6.6e-56 187.6 0.6 1.4 1 0 0 1 1 1 1 CBL proto-oncogene N-terminal domain 1 Cbl_N3 PF02762.12 001007330.1_16129001_1 - 1.7e-43 146.3 0.0 3.3e-43 145.3 0.0 1.5 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, SH2-like domain Cbl_N2 PF02761.12 001007330.1_16129001_1 - 9.7e-41 138.3 0.9 1.8e-40 137.4 0.9 1.5 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain Prok-RING_4 PF14447.4 001007330.1_16129001_1 - 7.3e-13 48.0 9.1 1.8e-12 46.8 9.1 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.4 001007330.1_16129001_1 - 6.9e-11 41.7 8.3 1.9e-10 40.3 8.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001007330.1_16129001_1 - 1e-08 34.7 7.9 2.9e-08 33.3 7.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001007330.1_16129001_1 - 4e-08 33.3 7.7 1e-07 32.0 7.7 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001007330.1_16129001_1 - 4.6e-05 23.0 8.1 0.00014 21.5 8.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) UBA PF00627.29 001007330.1_16129001_1 - 0.00027 20.6 0.0 0.00046 19.9 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain zf-RING_UBOX PF13445.4 001007330.1_16129001_1 - 0.00085 19.2 4.8 0.00093 19.0 3.2 2.0 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 001007330.1_16129001_1 - 0.0064 16.3 10.4 0.018 14.8 10.4 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.4 001007330.1_16129001_1 - 0.022 14.4 8.8 0.056 13.0 8.8 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.5 001007330.1_16129001_1 - 0.052 13.7 7.4 0.13 12.4 7.4 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.4 001007330.1_16129001_1 - 0.07 13.2 8.3 0.19 11.8 8.3 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-UDP PF14569.4 001007330.1_16129001_1 - 0.9 9.6 4.5 2.8 8.0 4.5 1.8 1 0 0 1 1 1 0 Zinc-binding RING-finger Trypsin PF00089.24 001139464.1_16122001_3 - 2.4e-72 243.2 0.6 2.8e-72 243.0 0.6 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 001139464.1_16122001_3 - 1.3e-08 35.1 0.0 2.4e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 001139464.1_16122001_3 - 2.4e-05 25.1 0.0 5e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain SR-25 PF10500.7 213394.1_16123001_1 - 0.19 11.2 20.2 0.35 10.3 20.2 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GST_N PF02798.18 213394.1_16123001_2 - 1.7e-18 66.6 0.0 4.5e-18 65.2 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 213394.1_16123001_2 - 5.2e-15 55.3 0.0 5.2e-15 55.3 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 213394.1_16123001_2 - 2e-12 47.1 0.1 2e-12 47.1 0.1 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 213394.1_16123001_2 - 0.00036 20.7 0.0 0.00083 19.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Peptidase_S49_N PF08496.8 213394.1_16123001_3 - 3.1 7.7 9.7 4.3 7.3 9.7 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal QueF_N PF14819.4 001015058.1_16121001_1 - 0.059 13.5 0.1 0.078 13.1 0.1 1.1 1 0 0 1 1 1 0 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term Globin PF00042.20 001015058.1_16121001_3 - 4.9e-26 91.3 0.0 7.6e-26 90.7 0.0 1.3 1 0 0 1 1 1 1 Globin TrbC_Ftype PF09673.8 001015058.1_16121001_3 - 0.057 13.3 0.0 0.087 12.7 0.0 1.2 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein Kelch_1 PF01344.23 001113477.1_16126001_2 - 1.3e-80 264.6 16.7 2.2e-16 59.0 0.7 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 001113477.1_16126001_2 - 3.8e-43 144.3 5.7 8e-09 35.4 0.0 6.4 2 2 4 6 6 6 5 Kelch motif BACK PF07707.13 001113477.1_16126001_2 - 1.1e-33 115.3 1.1 2.2e-33 114.3 1.1 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.4 001113477.1_16126001_2 - 3e-31 106.9 16.1 2e-06 27.8 0.1 7.1 7 0 0 7 7 7 6 Galactose oxidase, central domain BTB PF00651.29 001113477.1_16126001_2 - 1.6e-27 95.8 0.0 2.8e-27 95.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_2 PF07646.13 001113477.1_16126001_2 - 1.6e-24 84.8 9.7 7.1e-07 28.8 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.4 001113477.1_16126001_2 - 2.4e-23 81.7 3.4 0.00014 21.6 0.0 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.4 001113477.1_16126001_2 - 1.3e-07 31.2 9.9 0.00041 20.1 0.2 5.6 5 0 0 5 5 5 2 Kelch motif 7tm_1 PF00001.19 001308557.1_16123001_2 - 5.9e-25 87.9 15.2 8.4e-25 87.4 15.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Thioredoxin PF00085.18 001045561.1_16124001_3 - 1.3e-23 82.8 0.0 2.9e-23 81.7 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.4 001045561.1_16124001_3 - 2.2e-20 73.3 0.0 1.8e-18 67.0 0.2 2.1 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin_2 PF13098.4 001045561.1_16124001_3 - 5.3e-06 26.7 0.1 4.5e-05 23.7 0.0 2.5 2 1 0 2 2 2 1 Thioredoxin-like domain Acyl-CoA_dh_1 PF00441.22 001351649.2_16125001_2 - 4.8e-48 163.0 4.0 3.9e-47 160.1 0.6 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.14 001351649.2_16125001_2 - 1e-28 100.1 0.0 2.4e-28 98.9 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.17 001351649.2_16125001_2 - 2.2e-25 88.5 0.0 3.7e-25 87.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.9 001351649.2_16125001_2 - 2.5e-23 82.7 0.8 1.1e-22 80.7 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Chordopox_A15 PF05846.10 001256682.1_16124001_1 - 0.092 12.8 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Chordopoxvirus A15 protein CAF1 PF04857.18 001256682.1_16124001_3 - 2.2e-87 293.1 0.8 5.2e-44 150.6 0.2 2.2 1 1 1 2 2 2 2 CAF1 family ribonuclease zf-CCCH PF00642.22 001256682.1_16124001_3 - 0.0098 15.7 0.3 0.028 14.2 0.3 1.8 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Uso1_p115_head PF04869.12 200155.1_16127001_1 - 1.9e-64 217.6 1.6 2.4e-64 217.3 0.0 2.0 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.11 200155.1_16127001_1 - 3.9e-11 43.3 28.9 3.9e-11 43.3 28.9 5.1 3 1 1 5 5 5 1 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4407 PF14362.4 200155.1_16127001_1 - 1.6e-06 27.5 37.5 1.7e-05 24.2 16.1 2.6 1 1 1 2 2 2 2 Domain of unknown function (DUF4407) Reo_sigmaC PF04582.10 200155.1_16127001_1 - 0.0006 19.2 23.3 0.013 14.8 9.5 3.2 2 1 1 3 3 3 3 Reovirus sigma C capsid protein TSC22 PF01166.16 200155.1_16127001_1 - 0.025 14.7 25.2 0.043 14.0 0.5 5.2 3 1 1 4 4 4 0 TSC-22/dip/bun family Fib_alpha PF08702.8 200155.1_16127001_1 - 0.026 14.6 41.1 0.028 14.5 10.0 3.7 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Seryl_tRNA_N PF02403.20 200155.1_16127001_1 - 0.38 10.9 42.8 0.028 14.5 7.1 4.0 2 1 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Filament PF00038.19 200155.1_16127001_1 - 0.45 9.9 54.4 0.83 9.0 14.7 3.6 1 1 2 3 3 3 0 Intermediate filament protein Spc7 PF08317.9 200155.1_16127001_1 - 0.87 8.3 60.5 2.7 6.7 17.4 3.8 1 1 2 3 3 3 0 Spc7 kinetochore protein Cep57_CLD_2 PF14197.4 200155.1_16127001_1 - 3.3 7.7 44.2 0.27 11.2 12.7 4.6 3 2 0 3 3 3 0 Centrosome localisation domain of PPC89 Spond_N PF06468.11 131008.4_16123001_1 - 1.2e-74 250.5 0.2 1.5e-74 250.2 0.2 1.1 1 0 0 1 1 1 1 Spondin_N TSP_1 PF00090.17 131008.4_16123001_1 - 3.2e-05 23.9 2.5 6.8e-05 22.9 2.5 1.6 1 0 0 1 1 1 1 Thrombospondin type 1 domain GRASP55_65 PF04495.12 001007411.1_16125001_1 - 1.8e-63 212.8 0.0 5.9e-54 182.0 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.4 001007411.1_16125001_1 - 1e-08 35.2 0.0 6.8e-05 23.0 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.22 001007411.1_16125001_1 - 0.056 13.7 0.0 0.94 9.7 0.0 2.2 2 0 0 2 2 2 0 PDZ domain (Also known as DHR or GLGF) ATPase_gene1 PF09527.8 001007411.1_16125001_3 - 0.064 13.3 1.8 0.15 12.1 1.8 1.6 1 0 0 1 1 1 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter YccF PF03733.11 001025507.3_16126001_2 - 1.7e-17 63.7 15.0 1.7e-17 63.7 15.0 4.9 4 1 1 5 5 5 2 Inner membrane component domain Na_Ca_ex PF01699.22 001025507.3_16126001_2 - 3.5e-17 62.7 28.5 3.2e-12 46.5 15.6 3.7 4 0 0 4 4 4 2 Sodium/calcium exchanger protein DUF2556 PF10831.6 001025507.3_16126001_2 - 0.46 10.3 0.0 0.46 10.3 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2556) HLH PF00010.24 152967.1_16123001_1 - 1.4e-09 37.6 0.1 2.3e-09 36.9 0.1 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Methyltransf_13 PF08421.9 152967.1_16123001_1 - 0.29 11.3 1.8 12 6.1 0.0 3.6 4 0 0 4 4 4 0 Putative zinc binding domain GRASP55_65 PF04495.12 200703.2_16125001_2 - 2.2e-73 244.9 0.0 3e-54 182.9 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.4 200703.2_16125001_2 - 4.2e-09 36.5 0.0 5.4e-05 23.3 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.22 200703.2_16125001_2 - 0.0016 18.6 0.0 0.16 12.2 0.0 2.3 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) Filament PF00038.19 130963.2_16124001_2 - 1.3e-111 373.0 44.8 1.9e-111 372.5 44.8 1.2 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.12 130963.2_16124001_2 - 1.9e-22 79.8 11.6 1.9e-22 79.8 11.6 2.4 2 0 0 2 2 2 1 Intermediate filament head (DNA binding) region Reo_sigmaC PF04582.10 130963.2_16124001_2 - 0.00028 20.3 4.5 0.18 11.0 0.4 2.9 1 1 0 2 2 2 2 Reovirus sigma C capsid protein TolA_bind_tri PF16331.3 130963.2_16124001_2 - 0.00071 19.5 3.5 0.00071 19.5 3.5 6.5 4 1 1 6 6 6 1 TolA binding protein trimerisation AAA_13 PF13166.4 130963.2_16124001_2 - 0.029 12.9 27.7 0.25 9.8 17.6 2.3 1 1 1 2 2 2 0 AAA domain Spc7 PF08317.9 130963.2_16124001_2 - 0.054 12.2 36.0 0.84 8.3 16.0 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.10 130963.2_16124001_2 - 0.09 12.7 13.7 0.037 13.9 1.1 3.6 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus IncA PF04156.12 130963.2_16124001_2 - 0.24 11.1 45.5 0.041 13.5 9.7 4.1 1 1 4 5 5 5 0 IncA protein WD40_alt PF14077.4 130963.2_16124001_2 - 1.1 9.0 9.1 15 5.4 0.7 4.6 4 0 0 4 4 4 0 Alternative WD40 repeat motif CENP-F_leu_zip PF10473.7 130963.2_16124001_2 - 1.9 8.4 41.1 0.18 11.7 7.5 3.8 1 1 4 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KASH_CCD PF14662.4 130963.2_16124001_2 - 2.7 7.7 38.6 0.069 12.9 8.6 3.4 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH CENP-H PF05837.10 130963.2_16124001_2 - 3 8.1 30.4 2.9 8.2 6.0 4.1 2 2 1 4 4 4 0 Centromere protein H (CENP-H) DUF972 PF06156.11 130963.2_16124001_2 - 3.2 8.3 39.9 2 9.0 0.7 5.5 3 2 3 6 6 5 0 Protein of unknown function (DUF972) GAS PF13851.4 130963.2_16124001_2 - 3.3 6.9 40.6 0.014 14.6 11.4 3.7 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.10 130963.2_16124001_2 - 3.4 7.6 25.1 0.14 12.0 2.0 4.4 3 1 3 6 6 6 0 Protein of unknown function (DUF1664) DUF4407 PF14362.4 130963.2_16124001_2 - 3.8 6.6 28.3 7.5 5.7 14.3 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) GHMP_kinases_C PF08544.11 130963.2_16124001_2 - 4 7.7 5.3 17 5.7 0.1 3.7 4 0 0 4 4 3 0 GHMP kinases C terminal bZIP_1 PF00170.19 130963.2_16124001_2 - 5.7 7.0 24.8 1.4 9.0 2.8 6.0 4 1 3 7 7 7 0 bZIP transcription factor Homeobox PF00046.27 001045074.1_16122001_1 - 4.6e-25 87.1 6.1 1.2e-24 85.8 6.1 1.7 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 001045074.1_16122001_1 - 7.2e-10 38.2 2.1 1.7e-09 37.1 2.1 1.7 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 001045074.1_16122001_1 - 0.001 18.8 2.0 0.0013 18.4 0.1 2.2 2 0 0 2 2 2 1 Homeobox KN domain Filament PF00038.19 001328376.1_16124001_2 - 1.4e-111 372.9 44.8 2e-111 372.4 44.8 1.2 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.12 001328376.1_16124001_2 - 2e-22 79.7 11.6 2e-22 79.7 11.6 2.6 2 1 0 2 2 2 1 Intermediate filament head (DNA binding) region Reo_sigmaC PF04582.10 001328376.1_16124001_2 - 0.00033 20.0 4.7 0.22 10.7 0.3 2.9 1 1 1 3 3 3 3 Reovirus sigma C capsid protein TolA_bind_tri PF16331.3 001328376.1_16124001_2 - 0.00074 19.4 3.5 0.00074 19.4 3.5 6.5 4 1 1 6 6 6 1 TolA binding protein trimerisation GAS PF13851.4 001328376.1_16124001_2 - 0.0067 15.7 9.9 0.0067 15.7 9.9 3.8 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding Mis14 PF08641.10 001328376.1_16124001_2 - 0.0085 16.3 8.4 0.0085 16.3 8.4 3.7 1 1 1 3 3 1 1 Kinetochore protein Mis14 like AAA_13 PF13166.4 001328376.1_16124001_2 - 0.049 12.2 28.5 0.3 9.6 16.5 2.4 1 1 1 2 2 2 0 AAA domain Spc7 PF08317.9 001328376.1_16124001_2 - 0.062 12.0 36.1 0.083 11.6 10.2 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.10 001328376.1_16124001_2 - 0.068 13.1 13.1 0.04 13.8 0.8 3.6 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus IncA PF04156.12 001328376.1_16124001_2 - 0.33 10.6 46.7 0.025 14.2 8.8 4.2 1 1 1 4 4 4 0 IncA protein WD40_alt PF14077.4 001328376.1_16124001_2 - 1.2 8.9 9.1 15 5.4 0.7 4.6 4 0 0 4 4 4 0 Alternative WD40 repeat motif CENP-F_leu_zip PF10473.7 001328376.1_16124001_2 - 1.9 8.4 40.9 0.23 11.4 7.5 3.8 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.10 001328376.1_16124001_2 - 3.2 7.6 25.0 0.14 12.0 2.0 4.5 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) KASH_CCD PF14662.4 001328376.1_16124001_2 - 3.4 7.3 38.9 0.044 13.5 7.7 3.4 1 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH DUF972 PF06156.11 001328376.1_16124001_2 - 3.7 8.1 40.0 2 8.9 0.7 5.6 3 2 3 6 6 5 0 Protein of unknown function (DUF972) DUF4407 PF14362.4 001328376.1_16124001_2 - 4.4 6.4 28.8 6.1 6.0 14.0 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) GHMP_kinases_C PF08544.11 001328376.1_16124001_2 - 4.5 7.6 5.3 17 5.7 0.1 3.7 4 0 0 4 4 3 0 GHMP kinases C terminal bZIP_1 PF00170.19 001328376.1_16124001_2 - 6 6.9 24.6 1.4 8.9 2.8 6.0 4 1 2 6 6 6 0 bZIP transcription factor FXa_inhibition PF14670.4 001099228.3_16127001_2 - 4.3e-30 103.6 80.2 3.1e-09 36.8 9.3 6.7 7 0 0 7 7 7 5 Coagulation Factor Xa inhibitory site cEGF PF12662.5 001099228.3_16127001_2 - 4.4e-22 77.5 39.0 5.3e-09 35.7 0.7 5.9 5 0 0 5 5 5 5 Complement Clr-like EGF-like EGF_CA PF07645.13 001099228.3_16127001_2 - 1e-17 63.9 70.1 4.7e-07 29.8 8.9 5.9 5 0 0 5 5 5 4 Calcium-binding EGF domain EGF PF00008.25 001099228.3_16127001_2 - 1.1e-08 35.0 75.9 0.0018 18.4 6.6 6.4 5 0 0 5 5 5 4 EGF-like domain DUF3827 PF12877.5 001099228.3_16127001_2 - 0.13 10.5 0.0 0.18 10.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) EGF_3 PF12947.5 001099228.3_16127001_2 - 6.4 6.9 58.2 0.91 9.6 2.0 7.3 5 2 1 6 6 6 0 EGF domain TIMP PF00965.15 182874.1_16127001_2 - 1.2e-70 236.9 6.9 1.8e-70 236.3 6.9 1.3 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase Crystall PF00030.17 001017738.1_16122001_2 - 1.2e-54 182.3 7.4 5.7e-29 100.0 1.2 2.3 2 0 0 2 2 2 2 Beta/Gamma crystallin PNRC PF15365.4 001130192.1_16127001_1 - 2.8e-10 40.5 6.2 1.1e-09 38.6 6.2 2.0 1 1 0 1 1 1 1 Proline-rich nuclear receptor coactivator Tet_JBP PF12851.5 001327946.1_16129001_2 - 1.6e-106 356.3 0.0 3.3e-106 355.3 0.0 1.6 1 1 0 1 1 1 1 Oxygenase domain of the 2OGFeDO superfamily zf-C4 PF00105.16 205077.1_23527001_2 - 8.1e-31 106.2 14.4 2e-30 104.9 14.4 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 205077.1_23527001_2 - 2.6e-24 85.8 4.3 5.3e-24 84.8 4.3 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Laminin_N PF00055.15 205419.1_23525001_2 - 8.7e-88 293.7 0.4 8.7e-88 293.7 0.4 3.7 3 1 1 4 4 4 1 Laminin N-terminal (Domain VI) NTR PF01759.19 205419.1_23525001_2 - 3.5e-30 103.8 1.1 6.2e-30 103.0 1.1 1.4 1 0 0 1 1 1 1 UNC-6/NTR/C345C module Laminin_EGF PF00053.22 205419.1_23525001_2 - 2.2e-28 98.0 54.9 3.1e-10 39.9 14.6 4.3 3 0 0 3 3 3 3 Laminin EGF domain BNR_6 PF15899.3 205419.1_23525001_2 - 0.12 12.3 0.1 0.52 10.4 0.0 2.1 2 0 0 2 2 2 0 BNR-Asp box repeat FGF PF00167.16 182871.3_16123001_3 - 1.2e-39 135.1 1.6 1.9e-39 134.5 1.6 1.3 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 182871.3_16123001_3 - 4.2e-05 23.6 0.3 0.00019 21.5 0.0 2.0 2 0 0 2 2 2 1 Fascin domain Y_phosphatase PF00102.25 001007200.1_16126001_2 - 6.3e-73 245.1 0.1 1.1e-72 244.3 0.1 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase FERM_C PF09380.8 001007200.1_16126001_2 - 4.2e-26 91.0 0.1 1.1e-25 89.7 0.1 1.8 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.16 001007200.1_16126001_2 - 4.8e-21 75.2 1.2 7e-21 74.7 0.2 1.8 2 0 0 2 2 2 1 FERM central domain PDZ PF00595.22 001007200.1_16126001_2 - 4.3e-20 71.7 0.0 1.3e-19 70.2 0.1 1.8 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) FERM_N PF09379.8 001007200.1_16126001_2 - 3.8e-18 65.0 0.0 2e-17 62.7 0.0 2.1 2 0 0 2 2 2 1 FERM N-terminal domain FA PF08736.9 001007200.1_16126001_2 - 7.8e-11 41.8 0.3 1.8e-10 40.6 0.3 1.6 1 0 0 1 1 1 1 FERM adjacent (FA) DSPc PF00782.18 001007200.1_16126001_2 - 0.00017 21.2 0.0 0.00035 20.3 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 001007200.1_16126001_2 - 0.00057 19.9 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.4 001007200.1_16126001_2 - 0.00057 19.8 0.0 0.00098 19.0 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family 7tm_1 PF00001.19 001083832.1_16124001_2 - 2.6e-46 157.9 17.6 8.2e-46 156.3 17.6 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MFS_4 PF06779.12 001083832.1_16124001_2 - 0.087 12.0 5.0 0.075 12.2 2.2 1.9 2 0 0 2 2 2 0 Uncharacterised MFS-type transporter YbfB Zw10 PF06248.11 200141.2_16126001_2 - 1.2e-262 872.6 15.2 1.5e-262 872.2 15.2 1.1 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 COG5 PF10392.7 200141.2_16126001_2 - 0.0056 16.7 2.6 0.02 14.9 2.6 1.9 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Sec8_exocyst PF04048.12 200141.2_16126001_2 - 0.0059 16.4 5.5 0.0085 15.9 3.6 2.4 3 0 0 3 3 3 1 Sec8 exocyst complex component specific domain Vps53_N PF04100.10 200141.2_16126001_2 - 0.013 14.4 5.0 0.11 11.2 4.9 2.1 1 1 0 1 1 1 0 Vps53-like, N-terminal Vps51 PF08700.9 200141.2_16126001_2 - 0.53 10.3 5.2 0.11 12.5 0.6 2.3 2 0 0 2 2 2 0 Vps51/Vps67 Com_YlbF PF06133.9 200141.2_16126001_2 - 0.57 10.7 7.3 2.5 8.6 6.3 2.5 1 1 1 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA Med9 PF07544.11 200141.2_16126001_2 - 2 8.4 5.4 5.2 7.1 2.0 3.3 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DivIC PF04977.13 200141.2_16126001_2 - 2.7 7.7 6.0 14 5.4 0.1 2.9 2 0 0 2 2 2 0 Septum formation initiator DUF1664 PF07889.10 200141.2_16126001_2 - 5.9 6.8 6.2 37 4.2 4.3 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) zf-C2H2 PF00096.24 194371.2_16124001_2 - 3.4e-11 42.8 35.6 5.7e-06 26.4 0.7 4.9 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 194371.2_16124001_2 - 5.6e-09 35.9 5.8 3.8e-06 27.0 0.9 5.4 6 0 0 6 6 6 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 194371.2_16124001_2 - 1.3e-05 25.5 9.4 0.0013 19.3 2.4 5.9 6 0 0 6 6 6 3 C2H2-type zinc finger Connexin PF00029.17 131812.1_16123001_1 - 3.6e-93 311.4 0.4 3.6e-93 311.4 0.4 1.6 2 0 0 2 2 2 1 Connexin Homeobox PF00046.27 131227.1_16123001_2 - 7e-23 80.1 4.9 1.2e-22 79.3 4.9 1.4 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 131227.1_16123001_2 - 6.2e-10 38.4 1.4 7.7e-10 38.1 0.1 1.9 2 0 0 2 2 2 1 OAR domain Gtr1_RagA PF04670.10 001020635.1_16123001_2 - 2.4e-72 242.9 0.7 3e-72 242.6 0.7 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.19 001020635.1_16123001_2 - 2.1e-05 23.9 0.0 3.3e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001020635.1_16123001_2 - 2.4e-05 23.7 0.0 4e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 001020635.1_16123001_2 - 0.00013 22.0 0.0 0.00022 21.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001020635.1_16123001_2 - 0.036 13.5 0.0 0.054 13.0 0.0 1.3 1 0 0 1 1 1 0 Ras family AAA_16 PF13191.4 001020635.1_16123001_2 - 0.049 13.9 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.21 001020635.1_16123001_2 - 0.058 13.4 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_14 PF13173.4 001020635.1_16123001_2 - 0.11 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Y_phosphatase PF00102.25 001083814.1_16129001_2 - 3.3e-83 278.7 0.2 5e-83 278.1 0.2 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.19 001083814.1_16129001_2 - 2.2e-24 85.4 10.5 7.1e-07 29.4 0.1 5.9 5 0 0 5 5 5 4 Fibronectin type III domain DSPc PF00782.18 001083814.1_16129001_2 - 6.2e-05 22.7 0.0 0.00014 21.5 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 001083814.1_16129001_2 - 0.00072 19.5 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.4 001083814.1_16129001_2 - 0.001 19.1 0.0 0.0023 17.9 0.0 1.6 1 0 0 1 1 1 1 Inositol hexakisphosphate Myotub-related PF06602.12 001083814.1_16129001_2 - 0.0021 16.9 0.0 0.0035 16.2 0.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Pur_ac_phosph_N PF16656.3 001083814.1_16129001_2 - 0.013 15.9 9.9 5.4 7.5 0.7 4.5 2 1 1 3 3 3 0 Purple acid Phosphatase, N-terminal domain DUF4981 PF16353.3 001083814.1_16129001_2 - 0.11 12.8 0.0 0.42 11.0 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function(DUF4981) Ank_2 PF12796.5 213078.1_16128001_3 - 9.4e-62 205.5 11.8 9e-14 51.7 0.1 5.3 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.4 213078.1_16128001_3 - 4.5e-55 183.2 11.7 2.9e-11 43.5 0.1 8.3 3 2 5 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.28 213078.1_16128001_3 - 4.4e-52 172.2 23.1 1.3e-05 25.3 0.1 10.6 10 0 0 10 10 10 10 Ankyrin repeat Pkinase PF00069.23 213078.1_16128001_3 - 9e-46 156.2 0.0 1.4e-45 155.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ank_5 PF13857.4 213078.1_16128001_3 - 3.2e-44 148.1 21.5 2.8e-09 37.0 0.1 9.2 1 1 7 9 9 9 9 Ankyrin repeats (many copies) Ank_3 PF13606.4 213078.1_16128001_3 - 1.1e-43 142.1 7.9 0.0012 19.0 0.0 10.8 10 0 0 10 10 10 8 Ankyrin repeat Pkinase_Tyr PF07714.15 213078.1_16128001_3 - 1.5e-42 145.5 0.0 2.9e-42 144.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase SLBP_RNA_bind PF15247.4 001256194.1_16123001_2 - 1.4e-29 101.8 8.5 2.5e-29 101.1 5.4 2.5 2 0 0 2 2 2 1 Histone RNA hairpin-binding protein RNA-binding domain Ank_2 PF12796.5 213184.2_16123001_1 - 2.7e-24 85.4 4.3 2.2e-14 53.7 0.1 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 213184.2_16123001_1 - 3.8e-21 75.0 8.1 9.2e-08 32.4 0.0 4.9 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 213184.2_16123001_1 - 2.4e-20 70.3 6.1 0.001 19.2 0.1 6.0 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.4 213184.2_16123001_1 - 3.4e-19 68.5 8.7 4.6e-07 29.9 0.2 5.0 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.28 213184.2_16123001_1 - 4.9e-17 61.4 15.2 0.00051 20.3 0.1 6.0 7 0 0 7 7 7 4 Ankyrin repeat GSHPx PF00255.17 001004634.2_16122001_1 - 3.9e-38 129.2 0.2 5.5e-38 128.7 0.2 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.19 001004634.2_16122001_1 - 0.022 14.5 0.0 0.14 12.0 0.0 2.1 1 1 0 1 1 1 0 AhpC/TSA family zf-H2C2_2 PF13465.4 180973.3_16127001_1 - 2.8e-11 43.2 10.1 4.4e-07 29.9 3.3 5.3 6 0 0 6 6 6 2 Zinc-finger double domain zf-C2H2 PF00096.24 180973.3_16127001_1 - 1.1e-10 41.2 30.3 3.8e-06 26.9 0.8 4.6 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 180973.3_16127001_1 - 3.3e-07 30.4 26.9 0.0034 17.9 0.8 4.9 3 1 1 4 4 4 3 C2H2-type zinc finger Rdx PF10262.7 194417.3_16126001_2 - 4.1e-09 36.4 0.0 7.8e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 Rdx family fn3 PF00041.19 001316727.1_16129001_1 - 2.8e-124 405.6 39.1 5.5e-10 39.3 0.0 16.4 17 0 0 17 17 17 15 Fibronectin type III domain Y_phosphatase PF00102.25 001316727.1_16129001_1 - 2.6e-75 252.9 0.7 5e-75 251.9 0.7 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF4249 PF14054.4 001316727.1_16129001_1 - 3.7e-09 36.5 1.4 0.82 9.1 0.0 7.3 3 2 0 5 5 5 2 Domain of unknown function (DUF4249) Interfer-bind PF09294.8 001316727.1_16129001_1 - 0.00015 21.9 10.9 3.8 7.8 0.6 6.4 8 1 0 8 8 8 2 Interferon-alpha/beta receptor, fibronectin type III DSPc PF00782.18 001316727.1_16129001_1 - 0.0012 18.5 0.0 0.0028 17.3 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 001316727.1_16129001_1 - 0.066 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.4 001316727.1_16129001_1 - 0.085 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Glyco_hydro_66 PF13199.4 001316727.1_16129001_1 - 0.12 10.8 0.0 1.7 7.0 0.0 2.6 2 0 0 2 2 2 0 Glycosyl hydrolase family 66 DUF2369 PF10179.7 001316727.1_16129001_1 - 0.13 12.7 6.1 5 7.5 0.0 6.3 10 0 0 10 10 10 0 Uncharacterised conserved protein (DUF2369) Y_phosphatase PF00102.25 001044313.2_16127001_1 - 5.4e-73 245.3 0.0 8.3e-73 244.7 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase FERM_C PF09380.8 001044313.2_16127001_1 - 3.1e-26 91.5 0.1 6.9e-26 90.3 0.1 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.16 001044313.2_16127001_1 - 5.5e-23 81.5 0.2 1.5e-22 80.1 0.2 1.8 1 0 0 1 1 1 1 FERM central domain PDZ PF00595.22 001044313.2_16127001_1 - 1.9e-19 69.6 0.1 4.6e-19 68.4 0.1 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) FERM_N PF09379.8 001044313.2_16127001_1 - 2e-18 65.9 0.4 2.4e-17 62.5 0.2 2.3 2 0 0 2 2 2 1 FERM N-terminal domain FA PF08736.9 001044313.2_16127001_1 - 6.7e-15 54.8 2.0 1.8e-14 53.4 2.0 1.8 1 0 0 1 1 1 1 FERM adjacent (FA) Y_phosphatase3 PF13350.4 001044313.2_16127001_1 - 0.00014 21.8 0.0 0.00023 21.0 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 001044313.2_16127001_1 - 0.00029 20.5 0.0 0.0006 19.5 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 001044313.2_16127001_1 - 0.0064 16.5 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate PDZ_2 PF13180.4 001044313.2_16127001_1 - 0.12 12.6 0.1 0.27 11.5 0.1 1.5 1 0 0 1 1 1 0 PDZ domain WD40 PF00400.30 001082994.1_16129001_2 - 1.9e-45 151.8 28.2 6e-10 39.4 0.3 8.5 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001082994.1_16129001_2 - 3.5e-26 91.2 0.8 2.2e-08 34.1 0.0 5.6 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.9 001082994.1_16129001_2 - 2.9e-09 36.5 0.1 1.2e-08 34.5 0.1 2.1 2 0 0 2 2 2 1 LisH Frizzled PF01534.15 204222.1_23525001_1 - 1.1e-140 468.2 19.0 1.4e-140 467.9 19.0 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.20 204222.1_23525001_1 - 4e-33 114.3 3.8 8.9e-33 113.2 3.8 1.6 1 0 0 1 1 1 1 Fz domain HTH_psq PF05225.14 001031160.1_23526001_1 - 4.5e-24 83.8 0.0 8.2e-16 57.4 0.0 2.4 2 0 0 2 2 2 2 helix-turn-helix, Psq domain zf-C2H2 PF00096.24 204254.1_23525001_2 - 3.4e-20 71.2 31.9 1.4e-05 25.2 0.2 5.7 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 204254.1_23525001_2 - 6.8e-18 64.1 34.6 1.5e-07 31.4 0.3 6.0 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 204254.1_23525001_2 - 5.3e-12 45.3 26.5 0.013 16.2 2.5 6.1 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 204254.1_23525001_2 - 2.8e-06 27.3 11.7 0.25 11.6 0.2 5.1 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 204254.1_23525001_2 - 0.00013 21.6 8.6 0.27 11.1 1.8 4.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_8 PF15909.3 204254.1_23525001_2 - 0.0065 16.6 12.4 0.095 12.9 2.1 3.1 1 1 2 3 3 3 3 C2H2-type zinc ribbon zf-met PF12874.5 204254.1_23525001_2 - 0.0078 16.4 1.6 0.0078 16.4 1.6 4.6 4 0 0 4 4 4 1 Zinc-finger of C2H2 type Connexin PF00029.17 204931.1_23523001_1 - 6.1e-88 294.2 7.5 6.1e-88 294.2 7.5 1.6 2 0 0 2 2 2 1 Connexin NO_synthase PF02898.13 204961.1_23529001_3 - 5.5e-190 630.9 0.1 7.9e-190 630.4 0.1 1.2 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.18 204961.1_23529001_3 - 1.2e-68 230.8 0.0 1.9e-68 230.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 204961.1_23529001_3 - 4.7e-43 146.7 0.0 1e-42 145.6 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.19 204961.1_23529001_3 - 7.1e-22 78.0 0.0 1.8e-21 76.7 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.10 204961.1_23529001_3 - 0.014 15.4 0.0 0.22 11.5 0.0 3.0 2 1 0 2 2 2 0 Ferric reductase NAD binding domain DUF3793 PF12672.5 204961.1_23529001_3 - 0.048 13.6 0.3 0.13 12.2 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3793) DUF1400 PF07176.9 204961.1_23529001_3 - 0.1 12.7 0.1 0.43 10.7 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1400) Crystall PF00030.17 204180.1_23522001_2 - 9.6e-59 195.4 4.3 2.6e-29 101.1 0.3 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 204180.1_23522001_2 - 3.9e-07 29.8 0.0 0.035 13.9 0.0 2.4 2 0 0 2 2 2 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 204180.1_23522001_2 - 0.0011 19.0 0.2 1.3 9.1 0.0 2.5 2 1 0 2 2 2 2 Beta/Gamma crystallin MRI PF15325.4 204180.1_23522001_2 - 0.39 11.8 2.1 0.64 11.1 2.1 1.3 1 0 0 1 1 1 0 Modulator of retrovirus infection tRNA-synt_1 PF00133.20 001006397.1_23527001_3 - 1.2e-168 562.0 0.3 1.9e-168 561.3 0.3 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.11 001006397.1_23527001_3 - 8.8e-27 93.8 0.0 2.5e-26 92.3 0.0 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.9 001006397.1_23527001_3 - 2.8e-26 92.1 0.5 7.8e-18 64.3 0.0 3.4 3 0 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.4 001006397.1_23527001_3 - 3.3e-06 26.6 0.0 6.1e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.17 001006397.1_23527001_3 - 0.00018 20.8 0.0 0.062 12.5 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain VWA PF00092.26 205334.1_23529001_1 - 4.1e-112 372.2 0.5 2e-55 187.6 0.3 2.9 3 0 0 3 3 3 2 von Willebrand factor type A domain fn3 PF00041.19 205334.1_23529001_1 - 3.4e-97 318.8 7.4 2.8e-14 53.1 0.0 8.3 8 0 0 8 8 8 8 Fibronectin type III domain Collagen PF01391.16 205334.1_23529001_1 - 1.1e-36 124.2 165.7 2.8e-08 33.3 26.1 5.5 2 2 3 5 5 5 5 Collagen triple helix repeat (20 copies) VWA_2 PF13519.4 205334.1_23529001_1 - 4e-31 107.7 0.0 3.2e-17 63.0 0.0 2.9 3 0 0 3 3 3 2 von Willebrand factor type A domain DUF2369 PF10179.7 205334.1_23529001_1 - 1.1e-09 38.5 0.2 10 6.5 0.0 7.2 7 0 0 7 7 7 3 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 205334.1_23529001_1 - 5.9e-07 29.6 0.0 12 6.1 0.0 6.7 6 1 1 7 7 7 1 Interferon-alpha/beta receptor, fibronectin type III DUF4959 PF16323.3 205334.1_23529001_1 - 8.1e-05 22.8 0.1 0.038 14.2 0.0 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF4959) Nucleopor_Nup85 PF07575.11 001003625.1_16125001_1 - 6.7e-180 599.3 11.2 8.3e-180 599.0 11.2 1.1 1 0 0 1 1 1 1 Nup85 Nucleoporin Pkinase_Tyr PF07714.15 205319.2_23526001_2 - 3.7e-104 347.5 0.0 5e-104 347.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 205319.2_23526001_2 - 4.7e-45 153.9 0.0 8.3e-45 153.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 205319.2_23526001_2 - 9.7e-37 124.8 0.0 1.1e-14 54.1 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 205319.2_23526001_2 - 1.3e-35 121.8 0.0 4e-12 46.5 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 205319.2_23526001_2 - 5.7e-26 90.6 0.0 1.3e-10 41.3 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 205319.2_23526001_2 - 3.6e-24 84.6 0.0 6e-08 32.6 0.0 4.5 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 205319.2_23526001_2 - 3.1e-15 56.1 1.1 0.00064 19.7 0.0 5.5 4 2 0 4 4 4 3 Immunoglobulin V-set domain Ig_5 PF16681.3 205319.2_23526001_2 - 1.7e-06 28.3 0.0 0.35 11.2 0.0 3.9 3 2 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 205319.2_23526001_2 - 0.0067 16.3 0.1 0.78 9.7 0.1 3.7 3 1 1 4 4 4 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 205319.2_23526001_2 - 0.023 14.6 0.0 9.3 6.2 0.0 3.1 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Kinase-like PF14531.4 205319.2_23526001_2 - 0.069 12.3 0.0 0.26 10.4 0.0 1.8 2 0 0 2 2 2 0 Kinase-like Sec16_C PF12931.5 001031269.1_23526001_2 - 6.4e-45 154.0 0.4 1.3e-44 153.0 0.0 1.7 2 0 0 2 2 2 1 Sec23-binding domain of Sec16 Sec16 PF12932.5 001031269.1_23526001_2 - 4.3e-07 30.4 0.0 1e-06 29.2 0.0 1.7 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Neur_chan_memb PF02932.14 204814.1_23524001_1 - 4.4e-113 377.1 5.7 1.6e-112 375.2 5.7 1.8 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 204814.1_23524001_1 - 9.4e-76 253.9 4.2 1.3e-75 253.4 4.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF2417 PF10329.7 204814.1_23524001_1 - 0.23 10.7 8.2 0.54 9.5 8.2 1.6 1 0 0 1 1 1 0 Region of unknown function (DUF2417) Claudin_2 PF13903.4 204814.1_23524001_1 - 2.9 7.5 5.8 0.6 9.7 0.6 2.4 3 0 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction Yip1 PF04893.15 001012566.1_23524001_3 - 2.6e-07 30.4 13.0 4e-07 29.8 13.0 1.4 1 0 0 1 1 1 1 Yip1 domain YIF1 PF03878.13 001012566.1_23524001_3 - 0.0011 18.4 11.3 0.064 12.6 11.3 2.1 1 1 0 1 1 1 1 YIF1 Romo1 PF10247.7 001012566.1_23524001_3 - 0.02 15.1 0.6 0.053 13.7 0.6 1.7 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 PRP38 PF03371.13 213489.1_16125001_3 - 2.5e-52 177.1 0.0 3.6e-52 176.6 0.0 1.2 1 0 0 1 1 1 1 PRP38 family Ion_trans PF00520.29 205220.2_23526001_1 - 2.5e-33 115.2 11.7 3.6e-33 114.7 11.7 1.2 1 0 0 1 1 1 1 Ion transport protein CLZ PF16526.3 205220.2_23526001_1 - 2.6e-28 98.0 4.3 9.7e-28 96.2 4.3 2.1 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels cNMP_binding PF00027.27 205220.2_23526001_1 - 6.1e-18 64.5 0.0 9.8e-18 63.8 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Connexin PF00029.17 205220.2_23526001_1 - 0.00091 18.9 1.2 0.0018 18.0 1.2 1.4 1 0 0 1 1 1 1 Connexin CDC45 PF02724.12 205220.2_23526001_1 - 0.0021 16.4 0.6 0.003 15.8 0.6 1.2 1 0 0 1 1 1 1 CDC45-like protein FLO_LFY PF01698.14 205220.2_23526001_1 - 0.01 15.0 1.1 0.015 14.4 1.1 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein Ion_trans_2 PF07885.14 205220.2_23526001_1 - 0.029 14.2 4.0 0.093 12.6 4.0 2.0 1 0 0 1 1 1 0 Ion channel DDHD PF02862.15 205220.2_23526001_1 - 0.034 14.1 0.1 0.052 13.5 0.1 1.3 1 0 0 1 1 1 0 DDHD domain Tim54 PF11711.6 205220.2_23526001_1 - 0.044 12.4 5.5 0.074 11.7 5.5 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CPSF100_C PF13299.4 205220.2_23526001_1 - 0.049 13.7 4.5 0.096 12.7 4.5 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SlyX PF04102.10 205220.2_23526001_1 - 0.086 13.3 2.3 0.21 12.1 1.2 2.1 2 0 0 2 2 2 0 SlyX Eapp_C PF10238.7 205220.2_23526001_1 - 0.094 12.7 3.5 0.19 11.7 3.5 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein Menin PF05053.11 205220.2_23526001_1 - 0.1 10.8 2.3 0.16 10.1 2.3 1.2 1 0 0 1 1 1 0 Menin DUF1510 PF07423.9 205220.2_23526001_1 - 0.21 10.9 14.9 0.36 10.1 14.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) NPR3 PF03666.11 205220.2_23526001_1 - 0.26 9.9 7.1 0.4 9.3 7.1 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.20 205220.2_23526001_1 - 0.31 10.1 2.3 0.49 9.4 2.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Sec62 PF03839.14 205220.2_23526001_1 - 0.78 9.1 14.4 0.15 11.4 9.7 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 RNA_pol_Rpc4 PF05132.12 205220.2_23526001_1 - 0.84 9.9 8.6 1.4 9.2 8.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 RR_TM4-6 PF06459.10 205220.2_23526001_1 - 1.1 8.9 12.4 2.1 8.0 12.4 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NARP1 PF12569.6 205220.2_23526001_1 - 1.8 7.2 20.0 3.1 6.4 20.0 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF3464 PF11947.6 205220.2_23526001_1 - 1.9 8.1 7.3 3.9 7.1 7.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) SpoIIP PF07454.9 205220.2_23526001_1 - 2.7 7.2 13.9 5.1 6.3 13.9 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.15 205220.2_23526001_1 - 3.2 6.2 7.4 6.1 5.4 7.4 1.3 1 0 0 1 1 1 0 Presenilin EOS1 PF12326.6 205220.2_23526001_1 - 8 6.2 10.4 17 5.1 0.1 2.4 2 0 0 2 2 2 0 N-glycosylation protein DUF4834 PF16118.3 205220.2_23526001_2 - 0.28 12.1 7.1 0.61 11.0 7.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Rap_GAP PF02145.13 001030676.2_23528001_2 - 1.1e-68 230.3 0.1 2e-68 229.5 0.1 1.5 1 0 0 1 1 1 1 Rap/ran-GAP CNH PF00780.20 001030676.2_23528001_2 - 2.1e-67 227.5 0.3 3.8e-67 226.7 0.3 1.4 1 0 0 1 1 1 1 CNH domain Collagen PF01391.16 205305.1_23526001_2 - 2.3e-92 302.6 345.5 2.6e-09 36.6 29.1 12.2 3 3 8 11 11 11 10 Collagen triple helix repeat (20 copies) zf-C3HC4 PF00097.23 001014358.1_16124001_2 - 5.8e-06 26.0 13.8 1.1e-05 25.1 13.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001014358.1_16124001_2 - 8.3e-05 22.6 14.6 0.00018 21.6 14.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.4 001014358.1_16124001_2 - 0.00014 21.6 11.4 0.00031 20.5 11.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 001014358.1_16124001_2 - 0.00027 20.7 16.8 0.00027 20.7 16.8 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 001014358.1_16124001_2 - 0.0045 17.0 12.6 0.0095 15.9 12.6 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.3 001014358.1_16124001_2 - 0.039 13.5 8.0 0.83 9.3 0.5 2.5 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_10 PF16685.3 001014358.1_16124001_2 - 0.61 10.1 13.0 1.2 9.2 13.0 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 W2 PF02020.16 200918.1_16124001_2 - 9.3e-23 80.0 4.7 2.9e-22 78.5 3.5 2.4 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Xpo1 PF08389.10 200918.1_16124001_2 - 0.27 11.2 2.5 1 9.3 2.5 2.0 1 1 0 1 1 1 0 Exportin 1-like protein Ig_3 PF13927.4 205266.1_23528001_3 - 1.9e-77 255.7 2.1 2.7e-13 50.2 0.3 7.5 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 205266.1_23528001_3 - 2.8e-72 238.7 0.0 5.5e-12 45.5 0.0 7.0 7 0 0 7 7 6 6 Immunoglobulin I-set domain fn3 PF00041.19 205266.1_23528001_3 - 2.7e-63 210.2 16.4 2.9e-14 53.1 0.1 5.5 5 0 0 5 5 5 5 Fibronectin type III domain Ig_2 PF13895.4 205266.1_23528001_3 - 2.4e-50 168.6 1.5 4.2e-09 36.5 0.0 6.5 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 205266.1_23528001_3 - 2.3e-46 155.7 0.0 5e-08 32.9 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin domain Bravo_FIGEY PF13882.4 205266.1_23528001_3 - 6.2e-27 94.7 6.7 1.3e-26 93.6 6.7 1.6 1 0 0 1 1 1 1 Bravo-like intracellular region V-set PF07686.15 205266.1_23528001_3 - 3.7e-14 52.6 4.7 0.059 13.4 0.0 9.0 7 3 1 8 8 8 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 205266.1_23528001_3 - 1.8e-13 50.3 0.5 0.074 13.0 0.0 6.7 5 1 1 6 6 6 3 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 205266.1_23528001_3 - 4e-07 30.2 0.0 0.31 11.3 0.0 5.4 5 0 0 5 5 5 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Pur_ac_phosph_N PF16656.3 205266.1_23528001_3 - 7.5e-06 26.3 5.7 0.03 14.7 0.0 5.7 6 0 0 6 6 5 1 Purple acid Phosphatase, N-terminal domain Adeno_E3_CR1 PF02440.13 205266.1_23528001_3 - 6.8e-05 22.5 3.3 0.15 11.7 0.0 4.4 5 0 0 5 5 5 2 Adenovirus E3 region protein CR1 Izumo-Ig PF16706.3 205266.1_23528001_3 - 0.00014 21.7 0.2 1.1 9.2 0.0 3.7 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.9 205266.1_23528001_3 - 0.00026 20.9 1.6 4.4 7.2 0.0 3.8 4 0 0 4 4 4 2 CD47 immunoglobulin-like domain SIT PF15330.4 205266.1_23528001_3 - 0.017 15.4 0.0 0.28 11.5 0.0 2.6 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT INCA1 PF15142.4 205266.1_23528001_3 - 0.059 13.2 0.1 0.14 12.0 0.1 1.6 1 0 0 1 1 1 0 INCA1 Invasin_D3 PF09134.8 205266.1_23528001_3 - 0.15 11.7 0.0 21 4.8 0.0 2.8 2 0 0 2 2 2 0 Invasin, domain 3 R3H PF01424.20 201125.1_16124001_2 - 6e-12 45.2 0.1 1.1e-11 44.3 0.1 1.5 1 0 0 1 1 1 1 R3H domain DNA_ligase_A_M PF01068.19 001030816.1_23528001_1 - 2.8e-55 187.0 0.4 4.9e-55 186.2 0.4 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.12 001030816.1_23528001_1 - 1.3e-41 142.7 0.2 2.4e-41 141.8 0.2 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.13 001030816.1_23528001_1 - 1.5e-18 67.1 0.0 6.1e-18 65.1 0.0 2.1 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region DNA_ligase_IV PF11411.6 001030816.1_23528001_1 - 3.4e-18 65.3 0.9 7.9e-18 64.1 0.9 1.7 1 0 0 1 1 1 1 DNA ligase IV BRCT PF00533.24 001030816.1_23528001_1 - 4.8e-15 55.6 0.0 1.3e-09 38.2 0.0 3.4 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 001030816.1_23528001_1 - 1.3e-12 47.8 0.0 1.1e-09 38.4 0.0 2.8 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.8 001030816.1_23528001_1 - 4.2e-11 43.3 0.2 1.2e-10 41.8 0.1 1.9 2 0 0 2 2 2 1 RNA ligase mRNA_cap_enzyme PF01331.17 001030816.1_23528001_1 - 0.0075 16.0 1.0 0.073 12.7 1.0 2.2 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain SKA1 PF07160.10 001030816.1_23528001_1 - 0.13 11.9 2.4 0.11 12.2 0.6 1.7 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 APG17 PF04108.10 001030816.1_23528001_1 - 0.17 10.8 0.5 0.31 10.0 0.5 1.4 1 0 0 1 1 1 0 Autophagy protein Apg17 Actin PF00022.17 204637.1_23523001_2 - 6.6e-84 281.7 0.0 8.2e-83 278.1 0.0 1.9 1 1 0 1 1 1 1 Actin PAW PF04721.15 001020601.1_16125001_2 - 3.3e-73 245.6 3.1 3.3e-73 245.6 3.1 1.5 2 0 0 2 2 2 1 PNGase C-terminal domain, mannose-binding module PAW PUB PF09409.8 001020601.1_16125001_2 - 8.1e-23 80.0 0.0 1.9e-22 78.8 0.0 1.7 1 0 0 1 1 1 1 PUB domain Transglut_core PF01841.17 001020601.1_16125001_2 - 2.8e-16 59.8 0.9 8e-16 58.4 0.1 2.2 2 0 0 2 2 2 1 Transglutaminase-like superfamily Rad4 PF03835.13 001020601.1_16125001_2 - 1.2e-12 47.6 0.4 2.8e-12 46.4 0.4 1.6 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Totivirus_coat PF05518.9 001020601.1_16125001_2 - 1.5 6.6 4.2 2.3 6.0 4.2 1.2 1 0 0 1 1 1 0 Totivirus coat protein SH2 PF00017.22 204626.1_23523001_1 - 1.4e-12 47.3 0.0 2.3e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.14 204626.1_23523001_1 - 3.8e-11 43.0 2.3 1.1e-10 41.6 2.3 1.8 1 0 0 1 1 1 1 SOCS box Stathmin PF00836.17 001004393.1_23522001_3 - 2.7e-54 182.7 19.5 2.7e-54 182.7 19.5 1.3 2 0 0 2 2 2 1 Stathmin family Exonuc_VII_L PF02601.13 001004393.1_23522001_3 - 0.077 12.4 5.8 0.098 12.1 5.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit HrpF PF06266.10 001004393.1_23522001_3 - 0.083 13.1 0.4 0.18 12.0 0.4 1.5 1 0 0 1 1 1 0 HrpF protein Amidohydro_1 PF01979.18 001020512.1_16129001_3 - 2.3e-37 128.9 0.3 2.9e-37 128.6 0.3 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 001020512.1_16129001_3 - 2.1e-12 47.1 0.9 7.5e-06 25.5 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family Shugoshin_N PF07558.9 205376.1_23529001_1 - 0.012 15.4 0.2 0.012 15.4 0.2 9.6 11 0 0 11 11 11 0 Shugoshin N-terminal coiled-coil region ERM PF00769.17 204751.1_23525001_3 - 7.7e-75 251.7 50.7 7.7e-75 251.7 50.7 2.5 2 1 1 3 3 3 1 Ezrin/radixin/moesin family FERM_C PF09380.8 204751.1_23525001_3 - 5.6e-28 97.0 0.0 1.7e-27 95.5 0.0 1.9 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.16 204751.1_23525001_3 - 1.3e-27 96.4 1.6 1.3e-27 96.4 1.6 3.3 2 1 0 2 2 2 1 FERM central domain FERM_N PF09379.8 204751.1_23525001_3 - 5.4e-15 55.0 0.8 2e-14 53.1 0.1 2.3 2 0 0 2 2 2 1 FERM N-terminal domain Hamartin PF04388.10 204751.1_23525001_3 - 5 5.5 26.6 7.3 5.0 26.6 1.1 1 0 0 1 1 1 0 Hamartin protein LSM PF01423.20 204599.1_23522001_2 - 5.4e-20 70.7 0.1 7.1e-20 70.3 0.1 1.2 1 0 0 1 1 1 1 LSM domain Xlink PF00193.15 205482.1_23524001_1 - 7.2e-63 208.9 0.1 7.2e-34 115.9 0.0 2.3 2 0 0 2 2 2 2 Extracellular link domain V-set PF07686.15 205482.1_23524001_1 - 2.2e-10 40.5 0.0 4.1e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 205482.1_23524001_1 - 6.3e-05 23.4 0.0 0.00016 22.1 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 205482.1_23524001_1 - 6.7e-05 22.8 0.0 0.00015 21.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 205482.1_23524001_1 - 0.003 17.7 0.0 0.032 14.4 0.0 2.3 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 205482.1_23524001_1 - 0.0073 16.3 0.0 0.019 15.0 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain LSR PF05624.12 205482.1_23524001_1 - 0.047 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) LRR_8 PF13855.4 001030747.2_23524001_1 - 3.5e-36 122.6 21.7 1.3e-14 53.6 2.6 4.3 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 001030747.2_23524001_1 - 2.5e-21 75.2 24.7 5.2e-05 23.4 2.8 6.1 1 1 5 7 7 7 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001030747.2_23524001_1 - 2.9e-12 46.3 5.1 5.4e-05 22.6 2.2 3.0 1 1 2 3 3 3 3 Leucine-rich repeat LRR_5 PF13306.4 001030747.2_23524001_1 - 5.2e-11 42.5 1.6 2.1e-05 24.3 0.3 3.1 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRRNT PF01462.16 001030747.2_23524001_1 - 2e-09 36.7 5.5 2e-09 36.7 5.5 3.4 4 0 0 4 4 4 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 001030747.2_23524001_1 - 0.0068 16.6 14.7 17 6.2 0.2 7.4 6 2 0 6 6 6 1 Leucine Rich Repeat FNIP PF05725.10 001030747.2_23524001_1 - 0.26 11.4 4.2 15 5.7 0.7 3.2 2 1 0 2 2 2 0 FNIP Repeat LRR_6 PF13516.4 001030747.2_23524001_1 - 0.67 10.0 19.8 1.6 8.9 0.0 6.4 6 0 0 6 6 6 0 Leucine Rich repeat DUF3512 PF12024.6 001005839.1_23525001_2 - 8.1e-87 290.5 0.2 8.1e-87 290.5 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3512) Bromodomain PF00439.23 001005839.1_23525001_2 - 2.2e-22 78.8 1.4 5.8e-22 77.4 1.4 1.8 1 0 0 1 1 1 1 Bromodomain Motile_Sperm PF00635.24 001005839.1_23525001_2 - 0.03 14.0 1.9 0.17 11.6 0.2 2.4 2 0 0 2 2 2 0 MSP (Major sperm protein) domain GntR PF00392.19 001005839.1_23525001_2 - 0.074 12.6 0.1 0.28 10.7 0.0 2.0 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family Med24_N PF11277.6 001005839.1_23525001_2 - 0.12 10.2 1.1 0.18 9.6 1.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal DUF2796 PF10986.6 001005839.1_23525001_2 - 5.2 6.9 10.8 0.16 11.8 3.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) eIF3_subunit PF08597.8 001005839.1_23525001_2 - 6 6.6 25.3 24 4.6 25.2 2.0 1 1 1 2 2 2 0 Translation initiation factor eIF3 subunit adh_short PF00106.23 001001201.1_23523001_1 - 1.3e-42 145.3 0.0 1.8e-42 144.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001001201.1_23523001_1 - 1.3e-25 90.2 0.0 2.1e-25 89.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001001201.1_23523001_1 - 7.7e-06 25.8 0.0 2.9e-05 23.9 0.0 1.8 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.8 001001201.1_23523001_1 - 0.0017 17.7 0.0 0.0023 17.2 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) SE PF08491.8 001001201.1_23523001_1 - 0.0066 15.4 0.0 0.011 14.6 0.0 1.3 1 0 0 1 1 1 1 Squalene epoxidase FAM92 PF06730.9 001003604.2_16123001_3 - 2.7e-92 308.1 13.2 3.5e-92 307.7 13.2 1.1 1 0 0 1 1 1 1 FAM92 protein Vps5 PF09325.8 001003604.2_16123001_3 - 0.012 15.1 12.9 0.033 13.6 12.9 1.8 1 1 0 1 1 1 0 Vps5 C terminal like VSG_B PF13206.4 001003604.2_16123001_3 - 0.16 11.0 8.0 0.27 10.3 8.0 1.3 1 0 0 1 1 1 0 Trypanosomal VSG domain ORMDL PF04061.12 001031325.1_23522001_3 - 1.7e-51 173.5 1.9 2.3e-51 173.0 1.9 1.2 1 0 0 1 1 1 1 ORMDL family YlaC PF10777.7 001031325.1_23522001_3 - 1.1 9.0 3.7 0.6 9.8 1.0 1.7 2 0 0 2 2 2 0 Inner membrane protein YlaC RabGAP-TBC PF00566.16 001012923.1_23528001_3 - 2e-58 197.4 4.4 4.4e-58 196.3 4.4 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3694 PF12473.6 001012923.1_23528001_3 - 3.9e-39 134.6 0.0 8.9e-39 133.4 0.0 1.6 1 0 0 1 1 1 1 Kinesin protein PTB PF08416.11 001012923.1_23528001_3 - 0.031 14.3 0.0 0.061 13.3 0.0 1.5 1 0 0 1 1 1 0 Phosphotyrosine-binding domain IFN-gamma PF00714.15 205149.1_23523001_1 - 4.9e-27 94.3 1.0 7.2e-27 93.8 1.0 1.2 1 0 0 1 1 1 1 Interferon gamma tRNA_int_endo_N PF02778.12 001030594.2_23525001_2 - 2e-18 65.7 1.2 1.3e-14 53.5 0.7 2.3 2 0 0 2 2 2 2 tRNA intron endonuclease, N-terminal domain tRNA_int_endo PF01974.15 001030594.2_23525001_2 - 1.4e-15 57.0 0.0 2.9e-15 55.9 0.0 1.6 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain FGF PF00167.16 205180.1_23523001_1 - 4.3e-40 136.5 0.0 6.4e-40 136.0 0.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 205180.1_23523001_1 - 0.0046 17.0 0.0 0.0077 16.3 0.0 1.3 1 0 0 1 1 1 1 Fascin domain RnaseA PF00074.18 001007942.1_23522001_1 - 2.6e-23 82.7 0.8 2.6e-23 82.7 0.8 1.6 2 0 0 2 2 2 1 Pancreatic ribonuclease Spore_coat_CotO PF14153.4 001007942.1_23522001_3 - 0.019 14.8 6.6 0.028 14.2 6.6 1.2 1 0 0 1 1 1 0 Spore coat protein CotO PBP1_TM PF14812.4 001007942.1_23522001_3 - 0.036 14.4 7.8 0.059 13.7 7.8 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3824 PF12868.5 001007942.1_23522001_3 - 0.04 14.4 1.7 0.08 13.5 1.7 1.4 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) FAM176 PF14851.4 001007942.1_23522001_3 - 0.51 9.9 10.1 0.78 9.3 10.1 1.2 1 0 0 1 1 1 0 FAM176 family Pox_Ag35 PF03286.12 001007942.1_23522001_3 - 0.52 9.9 12.3 0.76 9.4 12.3 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF4611 PF15387.4 001007942.1_23522001_3 - 1.4 9.1 12.1 2.3 8.4 12.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) PI3K_1B_p101 PF10486.7 001007942.1_23522001_3 - 1.4 6.4 3.2 1.8 6.1 3.2 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit PTPRCAP PF15713.3 001007942.1_23522001_3 - 2.2 8.4 13.2 3.5 7.8 13.2 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Cnd2 PF05786.12 001007942.1_23522001_3 - 2.2 6.6 10.5 2.7 6.3 10.5 1.0 1 0 0 1 1 1 0 Condensin complex subunit 2 CENP-B_dimeris PF09026.8 001007942.1_23522001_3 - 6.5 7.1 15.1 10 6.4 15.1 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RXT2_N PF08595.9 001007942.1_23522001_3 - 7.7 6.4 10.7 13 5.6 10.7 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal AIM3 PF17096.3 001007942.1_23522001_3 - 7.8 7.4 7.6 15 6.5 7.6 1.5 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 Phosphodiest PF01663.20 001013527.1_16125001_2 - 3.8e-74 250.3 1.5 4.7e-74 250.0 1.5 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.16 001013527.1_16125001_2 - 0.0022 17.3 0.0 0.0034 16.6 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily PglZ PF08665.10 001013527.1_16125001_2 - 0.0049 16.8 0.0 0.023 14.7 0.0 1.9 2 0 0 2 2 2 1 PglZ domain KilA-N PF04383.11 001013527.1_16125001_2 - 0.13 12.0 0.3 0.25 11.0 0.3 1.4 1 0 0 1 1 1 0 KilA-N domain PQQ_2 PF13360.4 001012812.1_23528001_2 - 8.7e-06 25.3 0.1 0.045 13.2 0.0 2.2 2 0 0 2 2 2 2 PQQ-like domain VCBS PF13517.4 001012812.1_23528001_2 - 7.4e-05 23.1 0.1 0.5 10.9 0.0 2.7 2 0 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.21 001012812.1_23528001_2 - 0.00016 21.6 3.2 0.099 12.7 0.3 2.5 2 0 0 2 2 2 2 FG-GAP repeat ARID PF01388.19 001031220.1_23529001_1 - 1.4e-16 60.8 0.0 2.9e-16 59.7 0.0 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain TES PF08034.9 001031220.1_23529001_3 - 0.18 11.9 3.0 0.34 11.1 3.0 1.4 1 0 0 1 1 1 0 Trematode eggshell synthesis protein Vps51 PF08700.9 001031172.1_23526001_3 - 2.5e-23 81.8 0.0 6e-23 80.6 0.0 1.7 1 0 0 1 1 1 1 Vps51/Vps67 Sec5 PF15469.4 001031172.1_23526001_3 - 1.5e-09 37.8 0.0 2.9e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Exocyst complex component Sec5 Dor1 PF04124.10 001031172.1_23526001_3 - 2.3e-09 36.2 1.0 4.2e-09 35.4 1.0 1.3 1 0 0 1 1 1 1 Dor1-like family COG2 PF06148.9 001031172.1_23526001_3 - 1.2e-05 25.2 0.0 3.5e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps54_N PF10475.7 001031172.1_23526001_3 - 0.0012 18.1 0.0 0.0019 17.4 0.0 1.2 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Talin_middle PF09141.8 001031172.1_23526001_3 - 0.038 13.9 0.5 0.21 11.5 0.3 2.1 2 0 0 2 2 2 0 Talin, middle domain COG5 PF10392.7 001031172.1_23526001_3 - 0.045 13.8 0.3 0.15 12.1 0.1 2.0 2 0 0 2 2 2 0 Golgi transport complex subunit 5 ZapB PF06005.10 001031172.1_23526001_3 - 0.26 11.6 0.9 0.72 10.2 0.0 2.2 2 0 0 2 2 2 0 Cell division protein ZapB PAW PF04721.15 001030988.1_23526001_2 - 4.4e-74 248.4 0.8 8.2e-74 247.6 0.8 1.5 1 0 0 1 1 1 1 PNGase C-terminal domain, mannose-binding module PAW PUB PF09409.8 001030988.1_23526001_2 - 1.2e-21 76.3 0.0 3.4e-21 74.8 0.0 1.9 1 0 0 1 1 1 1 PUB domain Transglut_core PF01841.17 001030988.1_23526001_2 - 1.2e-14 54.6 1.1 2.5e-14 53.5 1.1 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Rad4 PF03835.13 001030988.1_23526001_2 - 5.2e-12 45.5 1.4 8.7e-12 44.8 1.4 1.3 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Ion_trans PF00520.29 205221.1_23526001_3 - 1.8e-31 109.1 10.1 2.6e-31 108.6 10.1 1.2 1 0 0 1 1 1 1 Ion transport protein CLZ PF16526.3 205221.1_23526001_3 - 2.6e-30 104.4 5.3 2.6e-30 104.4 5.3 2.5 2 1 0 2 2 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels cNMP_binding PF00027.27 205221.1_23526001_3 - 8.6e-18 64.0 0.0 1.4e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Adaptin_binding PF10199.7 205221.1_23526001_3 - 0.00019 21.9 1.7 0.0019 18.6 0.4 2.3 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 CDC45 PF02724.12 205221.1_23526001_3 - 0.00059 18.1 1.6 0.00059 18.1 1.6 2.1 2 0 0 2 2 2 1 CDC45-like protein CPSF100_C PF13299.4 205221.1_23526001_3 - 0.0018 18.3 2.5 0.0042 17.2 2.5 1.6 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal Med19 PF10278.7 205221.1_23526001_3 - 0.0078 16.0 10.6 0.015 15.1 10.6 1.4 1 0 0 1 1 1 1 Mediator of RNA pol II transcription subunit 19 XhlA PF10779.7 205221.1_23526001_3 - 0.0081 16.2 0.0 11 6.2 0.0 3.2 2 0 0 2 2 2 0 Haemolysin XhlA DDHD PF02862.15 205221.1_23526001_3 - 0.013 15.5 0.1 0.025 14.6 0.1 1.5 1 0 0 1 1 1 0 DDHD domain Tim54 PF11711.6 205221.1_23526001_3 - 0.017 13.8 7.3 0.028 13.1 7.3 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Presenilin PF01080.15 205221.1_23526001_3 - 0.028 13.1 0.7 0.044 12.4 0.7 1.2 1 0 0 1 1 1 0 Presenilin Ion_trans_2 PF07885.14 205221.1_23526001_3 - 0.029 14.2 3.2 0.086 12.7 3.2 1.9 1 0 0 1 1 1 0 Ion channel DUF1510 PF07423.9 205221.1_23526001_3 - 0.029 13.7 19.1 0.055 12.8 19.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) NPR3 PF03666.11 205221.1_23526001_3 - 0.038 12.6 7.9 0.059 12.0 7.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RNA_pol_Rpc4 PF05132.12 205221.1_23526001_3 - 0.075 13.3 8.9 0.15 12.4 8.9 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Coilin_N PF15862.3 205221.1_23526001_3 - 0.1 12.3 14.5 0.24 11.0 14.5 1.7 1 0 0 1 1 1 0 Coilin N-terminus Zip PF02535.20 205221.1_23526001_3 - 0.11 11.6 0.4 0.17 10.9 0.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF948 PF06103.9 205221.1_23526001_3 - 0.14 12.3 0.2 11 6.2 0.0 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF913 PF06025.10 205221.1_23526001_3 - 0.19 10.5 1.9 0.33 9.7 1.9 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM76 PF16046.3 205221.1_23526001_3 - 0.53 9.5 18.2 0.3 10.3 0.4 2.2 2 0 0 2 2 2 0 FAM76 protein AAA_23 PF13476.4 205221.1_23526001_3 - 0.6 10.5 18.9 2.8 8.3 12.5 2.4 2 0 0 2 2 2 0 AAA domain IncA PF04156.12 205221.1_23526001_3 - 0.62 9.7 10.4 0.074 12.7 1.2 2.4 2 0 0 2 2 2 0 IncA protein DUF106 PF01956.14 205221.1_23526001_3 - 0.79 9.3 5.6 15 5.1 0.0 2.8 2 0 0 2 2 2 0 Integral membrane protein DUF106 MIP-T3 PF10243.7 205221.1_23526001_3 - 0.85 8.1 23.5 1.7 7.2 23.5 1.4 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 TMEM214 PF10151.7 205221.1_23526001_3 - 1.2 7.3 11.8 2 6.6 11.8 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator SpoIIP PF07454.9 205221.1_23526001_3 - 1.6 8.0 13.7 3 7.1 13.7 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RR_TM4-6 PF06459.10 205221.1_23526001_3 - 1.6 8.3 15.8 0.052 13.3 9.6 1.5 2 0 0 2 2 1 0 Ryanodine Receptor TM 4-6 NARP1 PF12569.6 205221.1_23526001_3 - 4.2 6.0 24.1 0.023 13.4 14.3 1.9 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 DUF3464 PF11947.6 205221.1_23526001_3 - 8.5 6.0 11.4 17 5.1 11.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) Ig_3 PF13927.4 131361.1_16129001_3 - 2.2e-80 265.2 14.6 9.5e-15 54.8 0.1 7.2 7 0 0 7 7 6 6 Immunoglobulin domain I-set PF07679.14 131361.1_16129001_3 - 1.4e-71 236.4 1.9 1.1e-14 54.1 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_2 PF13895.4 131361.1_16129001_3 - 2.6e-59 197.4 6.3 2.1e-10 40.7 0.0 6.5 5 1 1 6 6 6 6 Immunoglobulin domain ig PF00047.23 131361.1_16129001_3 - 7.4e-53 176.6 9.9 2.1e-11 43.7 0.0 7.1 7 1 0 7 7 6 6 Immunoglobulin domain fn3 PF00041.19 131361.1_16129001_3 - 8.8e-47 157.3 9.6 1.7e-09 37.8 0.0 5.9 6 0 0 6 6 5 5 Fibronectin type III domain V-set PF07686.15 131361.1_16129001_3 - 2e-24 85.7 19.9 0.00029 20.8 0.2 11.0 8 4 2 10 10 9 5 Immunoglobulin V-set domain Ig_5 PF16681.3 131361.1_16129001_3 - 2.4e-15 56.6 1.1 0.0098 16.2 0.0 6.5 6 1 0 6 6 6 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Bravo_FIGEY PF13882.4 131361.1_16129001_3 - 7.7e-15 55.9 3.9 7.7e-15 55.9 3.9 2.1 2 0 0 2 2 1 1 Bravo-like intracellular region C2-set_2 PF08205.10 131361.1_16129001_3 - 1.6e-10 40.8 10.1 0.38 10.7 0.0 7.3 6 1 1 7 7 7 3 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 131361.1_16129001_3 - 3.5e-08 33.7 3.9 0.49 10.8 0.1 6.8 6 0 0 6 6 6 2 Immunoglobulin C1-set domain Herpes_gE PF02480.14 131361.1_16129001_3 - 1.1e-06 27.6 0.0 2.3 6.7 0.0 4.7 3 2 1 5 5 5 2 Alphaherpesvirus glycoprotein E Pur_ac_phosph_N PF16656.3 131361.1_16129001_3 - 2.6e-06 27.8 5.0 0.72 10.3 0.4 5.7 6 0 0 6 6 5 2 Purple acid Phosphatase, N-terminal domain Izumo-Ig PF16706.3 131361.1_16129001_3 - 4.5e-06 26.5 0.2 1 9.3 0.0 5.0 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.6 131361.1_16129001_3 - 0.001 19.1 0.9 3.2 7.9 0.1 3.5 2 1 1 3 3 3 2 Natural killer cell receptor 2B4 SusE PF14292.4 131361.1_16129001_3 - 0.0012 19.1 0.2 36 4.7 0.0 4.8 5 0 0 5 5 3 0 SusE outer membrane protein DUF2207 PF09972.7 131361.1_16129001_3 - 0.0082 14.8 0.0 0.016 13.8 0.0 1.4 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Sp38 PF07354.10 131361.1_16129001_3 - 0.013 14.3 0.1 1.1 7.9 0.0 3.3 4 0 0 4 4 4 0 Zona-pellucida-binding protein (Sp38) Interfer-bind PF09294.8 131361.1_16129001_3 - 0.037 14.2 4.0 0.079 13.1 0.0 3.4 4 0 0 4 4 3 0 Interferon-alpha/beta receptor, fibronectin type III DUF4998 PF16389.3 131361.1_16129001_3 - 0.11 12.0 0.4 1.4 8.3 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function Glyco_hydro_36C PF16874.3 131361.1_16129001_3 - 0.12 12.8 0.0 2.2 8.7 0.0 2.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 36 C-terminal domain SWM_repeat PF13753.4 131361.1_16129001_3 - 0.13 12.3 0.3 2.8 8.0 0.0 2.9 2 1 0 2 2 2 0 Putative flagellar system-associated repeat WD40 PF00400.30 199557.1_16124001_3 - 5.9e-32 109.1 32.8 1.3e-05 25.8 0.3 8.3 9 0 0 9 9 9 7 WD domain, G-beta repeat NLE PF08154.10 199557.1_16124001_3 - 5.1e-18 65.2 0.0 1e-17 64.3 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain ANAPC4_WD40 PF12894.5 199557.1_16124001_3 - 0.0035 17.5 5.3 0.19 11.9 0.1 3.7 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 199557.1_16124001_3 - 1.6 7.2 8.4 1.6 7.1 0.2 3.3 2 2 2 4 4 4 0 Nucleoporin Nup120/160 RRM_1 PF00076.20 001012521.1_23529001_3 - 7.3e-50 166.5 0.0 8.9e-18 63.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.9 001012521.1_23529001_3 - 4.9e-08 32.8 0.0 0.35 10.8 0.0 3.6 3 0 0 3 3 3 3 RNA binding domain RRM_5 PF13893.4 001012521.1_23529001_3 - 9.5e-05 21.9 0.2 0.07 12.6 0.0 2.9 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001012521.1_23529001_3 - 0.0014 18.6 0.0 1.3 9.1 0.0 3.2 3 0 0 3 3 3 1 RNA recognition motif PHM7_cyt PF14703.4 001012521.1_23529001_3 - 0.017 15.2 1.5 5.4 7.1 0.2 3.4 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM_2 PF14605.4 001012521.1_23529001_3 - 0.044 13.6 0.0 0.88 9.5 0.0 2.7 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif I-set PF07679.14 204687.2_23524001_2 - 4.1e-41 138.8 1.6 1.8e-14 53.4 0.0 3.5 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 204687.2_23524001_2 - 5.9e-40 135.6 2.3 1.3e-14 54.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 204687.2_23524001_2 - 8.2e-30 102.7 8.5 2.1e-13 50.1 0.0 4.6 4 2 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.4 204687.2_23524001_2 - 2.1e-28 98.3 4.2 3.9e-10 39.8 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 204687.2_23524001_2 - 1.5e-15 57.1 8.0 4.2e-08 33.2 0.4 5.3 3 2 1 4 4 4 3 Immunoglobulin V-set domain Izumo-Ig PF16706.3 204687.2_23524001_2 - 6.8e-08 32.3 0.4 0.0092 15.9 0.2 3.8 3 1 0 3 3 3 2 Izumo-like Immunoglobulin domain Ig_5 PF16681.3 204687.2_23524001_2 - 3e-07 30.6 0.0 0.47 10.8 0.0 3.7 3 1 0 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set_CD47 PF08204.9 204687.2_23524001_2 - 0.0024 17.7 1.5 0.79 9.6 0.1 2.8 3 0 0 3 3 3 2 CD47 immunoglobulin-like domain C2-set_2 PF08205.10 204687.2_23524001_2 - 0.023 14.6 0.3 0.97 9.4 0.0 2.8 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain 2OG-FeII_Oxy_3 PF13640.4 001001530.1_23525001_1 - 2.4e-11 44.2 0.0 9.1e-11 42.4 0.0 2.1 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.18 001001530.1_23525001_1 - 3.1e-09 37.1 0.0 1.6e-08 34.8 0.0 2.2 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily TPR_2 PF07719.15 001001530.1_23525001_1 - 6.1e-06 25.8 14.1 0.031 14.2 0.9 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.4 001001530.1_23525001_1 - 0.0036 17.1 11.4 7.7 6.7 0.1 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat YfiO PF13525.4 001001530.1_23525001_1 - 0.0052 16.4 8.3 0.44 10.1 0.2 3.9 4 0 0 4 4 4 1 Outer membrane lipoprotein Fis1_TPR_C PF14853.4 001001530.1_23525001_1 - 0.01 15.7 2.2 0.017 15.1 0.1 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Oxygenase-NA PF09859.7 001001530.1_23525001_1 - 0.032 13.7 0.0 0.32 10.4 0.0 2.2 1 1 0 1 1 1 0 Oxygenase, catalysing oxidative methylation of damaged DNA TPR_1 PF00515.26 001001530.1_23525001_1 - 0.067 12.9 12.1 2.6 7.9 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.4 001001530.1_23525001_1 - 0.069 13.2 4.7 1.9 8.6 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.4 001001530.1_23525001_1 - 0.078 13.7 11.0 0.63 10.9 0.2 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.4 001001530.1_23525001_1 - 0.14 12.7 15.3 0.67 10.6 1.5 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Mac PF12464.6 001001530.1_23525001_1 - 0.53 10.4 2.9 2.5 8.3 0.9 2.8 3 0 0 3 3 2 0 Maltose acetyltransferase TPR_11 PF13414.4 001001530.1_23525001_1 - 7.6 6.2 7.4 50 3.6 0.3 3.9 4 0 0 4 4 4 0 TPR repeat zf-CCCH PF00642.22 001030984.1_23523001_3 - 0.0008 19.1 2.0 0.0015 18.3 2.0 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) HOIP-UBA PF16678.3 001030984.1_23523001_3 - 0.048 13.5 0.1 0.076 12.9 0.1 1.3 1 0 0 1 1 1 0 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase Neur_chan_memb PF02932.14 204813.1_23524001_3 - 1.7e-90 303.1 0.0 2.3e-90 302.7 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 204813.1_23524001_3 - 4.3e-73 245.2 2.1 6.1e-73 244.7 2.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF2417 PF10329.7 204813.1_23524001_3 - 0.077 12.3 8.2 0.028 13.7 4.4 1.9 2 0 0 2 2 2 0 Region of unknown function (DUF2417) DUF3099 PF11298.6 204813.1_23524001_3 - 9.6 6.3 6.7 0.98 9.5 0.5 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3099) ThiF PF00899.19 001006129.2_23524001_1 - 1.7e-22 79.9 0.0 3.1e-22 79.0 0.0 1.4 1 1 0 1 1 1 1 ThiF family E1_4HB PF16191.3 001006129.2_23524001_1 - 8e-06 25.8 0.0 0.011 15.8 0.0 3.5 3 0 0 3 3 3 2 Ubiquitin-activating enzyme E1 four-helix bundle Transket_pyr PF02779.22 001006129.2_23524001_1 - 0.049 13.2 0.4 0.13 11.8 0.4 1.6 1 0 0 1 1 1 0 Transketolase, pyrimidine binding domain Qua1 PF16274.3 204230.1_23524001_1 - 1.3e-30 105.0 3.2 2.9e-30 103.9 3.2 1.6 1 0 0 1 1 1 1 Qua1 domain Sam68-YY PF16568.3 204230.1_23524001_1 - 1.4e-14 54.4 35.9 2.1e-14 53.8 35.9 1.3 1 0 0 1 1 1 1 Tyrosine-rich domain of Sam68 KH_1 PF00013.27 204230.1_23524001_1 - 7.1e-11 41.6 0.0 1.2e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 KH domain cNMP_binding PF00027.27 001007845.1_23528001_3 - 4.2e-40 135.5 0.1 1.1e-18 66.9 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.15 001007845.1_23528001_3 - 7.8e-14 50.9 0.1 1.6e-13 49.9 0.1 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Cupin_2 PF07883.9 001007845.1_23528001_3 - 0.22 11.2 2.1 5.1 6.8 0.1 2.3 2 0 0 2 2 2 0 Cupin domain EURL PF06937.9 001020552.1_16123001_2 - 6.9e-150 498.0 3.5 8e-150 497.8 3.5 1.0 1 0 0 1 1 1 1 EURL protein Cytochrom_B561 PF03188.14 001020500.1_16122001_2 - 2.8e-47 160.1 13.3 2.8e-47 160.1 13.3 1.9 3 0 0 3 3 3 1 Eukaryotic cytochrome b561 ETRAMP PF09716.8 001020500.1_16122001_2 - 0.0011 18.9 0.1 0.0011 18.9 0.1 2.0 2 1 0 2 2 2 1 Malarial early transcribed membrane protein (ETRAMP) Trp_oprn_chp PF09534.8 001020500.1_16122001_2 - 0.085 12.5 0.1 0.085 12.5 0.1 2.9 3 1 1 4 4 4 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Phage_holin_2_4 PF16082.3 001020500.1_16122001_2 - 0.14 11.9 0.0 0.14 11.9 0.0 2.6 3 0 0 3 3 3 0 Bacteriophage holin family, superfamily II-like DUF4307 PF14155.4 001020500.1_16122001_2 - 0.19 11.5 0.0 0.19 11.5 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4307) SUR7 PF06687.10 001020500.1_16122001_2 - 1.9 7.9 18.5 1.3 8.5 8.6 2.8 3 0 0 3 3 3 0 SUR7/PalI family Ldh_1_N PF00056.21 205284.1_23524001_3 - 1.9e-48 164.0 0.3 2.7e-48 163.5 0.3 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 205284.1_23524001_3 - 6.7e-21 74.8 0.0 1.9e-20 73.3 0.0 1.7 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.14 205284.1_23524001_3 - 0.024 14.1 0.2 0.062 12.7 0.0 1.7 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase Pyr_redox_2 PF07992.12 205284.1_23524001_3 - 0.1 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAM199X PF15814.3 001003766.2_16124001_3 - 1.8e-211 700.8 19.6 2.1e-211 700.6 19.6 1.0 1 0 0 1 1 1 1 Protein family FAM199X Connexin PF00029.17 204586.2_23524001_3 - 8e-93 310.2 2.8 1.2e-92 309.7 2.8 1.2 1 0 0 1 1 1 1 Connexin Connexin43 PF03508.11 204586.2_23524001_3 - 6.2e-11 41.5 15.4 1.3e-10 40.5 15.4 1.6 1 0 0 1 1 1 1 Gap junction alpha-1 protein (Cx43) Connexin40_C PF16791.3 204586.2_23524001_3 - 1e-05 26.6 1.4 1.8e-05 25.8 1.4 1.3 1 0 0 1 1 1 1 Connexin 40 C-terminal domain TEX29 PF15839.3 204586.2_23524001_3 - 5 7.7 5.8 2.1 8.9 0.2 2.5 2 1 0 2 2 2 0 Testis-expressed sequence 29 protein Syntaxin_2 PF14523.4 204505.1_23529001_3 - 0.024 14.9 0.2 0.043 14.1 0.2 1.3 1 0 0 1 1 1 0 Syntaxin-like protein MFS_1 PF07690.14 001031321.1_23524001_1 - 3.2e-23 82.1 39.9 1.2e-13 50.6 21.3 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.4 001031321.1_23524001_1 - 6.1e-05 21.6 27.5 0.00019 20.0 27.2 1.9 1 1 0 1 1 1 1 MFS/sugar transport protein DEAD PF00270.27 001003864.1_16125001_2 - 1.2e-43 148.7 0.2 3.7e-43 147.2 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001003864.1_16125001_2 - 2.1e-27 95.5 0.0 1.2e-25 90.0 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 001003864.1_16125001_2 - 7.5e-12 45.4 2.7 1.5e-10 41.3 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 001003864.1_16125001_2 - 0.0052 17.0 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain Ndc1_Nup PF09531.8 001003864.1_16125001_2 - 0.088 11.3 6.6 0.12 10.9 6.6 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AAA PF00004.27 001003864.1_16125001_2 - 0.11 12.8 0.5 4.5 7.6 0.5 2.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Helicase_RecD PF05127.12 001003864.1_16125001_2 - 1.1 9.0 6.0 0.59 9.8 0.1 2.9 3 0 0 3 3 3 0 Helicase DUF2052 PF09747.7 001003864.1_16125001_2 - 1.5 8.8 17.4 2.7 7.9 17.4 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Lectin_C PF00059.19 205484.1_23522001_2 - 6.5e-26 91.0 7.1 9.9e-26 90.5 7.1 1.3 1 0 0 1 1 1 1 Lectin C-type domain RRM_1 PF00076.20 001030831.1_23524001_1 - 1.3e-32 111.3 0.0 1.4e-15 56.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.9 001030831.1_23524001_1 - 1.7e-28 98.3 2.8 1.7e-28 98.3 2.8 2.1 2 0 0 2 2 2 1 NOPS (NUC059) domain RRM_7 PF16367.3 001030831.1_23524001_1 - 0.00064 19.7 0.0 0.0042 17.1 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif Aldedh PF00171.20 001030831.1_23524001_1 - 3.7 5.8 5.1 5.4 5.3 5.1 1.2 1 0 0 1 1 1 0 Aldehyde dehydrogenase family PWI PF01480.15 001031494.1_23528001_2 - 6.1e-30 103.2 0.2 1.1e-29 102.4 0.2 1.4 1 0 0 1 1 1 1 PWI domain ETRAMP PF09716.8 001031494.1_23528001_2 - 1.8 8.6 22.4 0.62 10.0 3.6 3.3 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) OAD_gamma PF04277.11 001031494.1_23528001_3 - 0.51 10.8 2.4 1.2 9.6 2.4 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain WD40 PF00400.30 001005805.1_23523001_1 - 4.9e-42 141.0 24.9 2.5e-09 37.5 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001005805.1_23523001_1 - 4.9e-24 84.3 1.7 1e-05 25.6 0.0 6.4 2 1 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001005805.1_23523001_1 - 7.2e-08 31.6 3.6 0.028 13.3 0.0 4.7 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.14 001005805.1_23523001_1 - 1.2e-05 23.9 1.1 0.096 11.1 0.0 3.6 1 1 3 4 4 4 4 Cytochrome D1 heme domain Nup160 PF11715.6 001005805.1_23523001_1 - 3.7e-05 22.4 1.4 0.012 14.2 0.0 2.7 3 1 1 4 4 4 2 Nucleoporin Nup120/160 HPS3_N PF14761.4 001005805.1_23523001_1 - 0.00011 21.7 0.0 0.18 11.3 0.0 2.9 3 0 0 3 3 3 2 Hermansky-Pudlak syndrome 3 PD40 PF07676.10 001005805.1_23523001_1 - 0.00097 18.9 0.2 1.7 8.5 0.0 3.3 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat WD40_like PF17005.3 001005805.1_23523001_1 - 0.0073 15.5 0.1 0.71 9.0 0.0 2.9 2 1 1 3 3 3 1 WD40-like domain GSDH PF07995.9 001005805.1_23523001_1 - 0.0081 15.4 0.0 0.48 9.5 0.0 2.3 2 0 0 2 2 2 1 Glucose / Sorbosone dehydrogenase Frtz PF11768.6 001005805.1_23523001_1 - 0.0086 14.3 0.0 0.025 12.8 0.0 1.6 1 1 1 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz DUF2415 PF10313.7 001005805.1_23523001_1 - 0.016 15.0 0.0 0.39 10.6 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) PQQ PF01011.19 001005805.1_23523001_1 - 0.084 12.7 2.8 9.4 6.2 0.0 3.8 4 0 0 4 4 4 0 PQQ enzyme repeat MBF1 PF08523.8 001006203.1_23523001_2 - 8.9e-25 86.8 5.5 1.7e-24 85.9 5.5 1.5 1 0 0 1 1 1 1 Multiprotein bridging factor 1 HTH_3 PF01381.20 001006203.1_23523001_2 - 6e-12 45.3 0.2 1e-11 44.5 0.2 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.4 001006203.1_23523001_2 - 0.0012 19.0 0.0 0.002 18.3 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.5 001006203.1_23523001_2 - 0.097 12.6 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain TGFb_propeptide PF00688.16 001001461.1_23523001_1 - 9.9e-34 117.0 0.0 1.3e-33 116.7 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001001461.1_23523001_1 - 2.2e-28 99.1 1.1 6e-28 97.7 1.1 1.8 1 0 0 1 1 1 1 Transforming growth factor beta like domain LydB PF16084.3 001001461.1_23523001_1 - 0.088 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 LydA-holin antagonist SEA PF01390.18 204241.1_23529001_2 - 1.1e-31 109.1 4.0 1.6e-17 63.6 0.4 2.6 2 0 0 2 2 2 2 SEA domain DUF4214 PF13946.4 204241.1_23529001_2 - 0.0045 16.8 0.0 0.0096 15.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4214) WD40 PF00400.30 001030752.1_23526001_3 - 4.9e-12 46.0 5.3 0.0042 17.8 0.0 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001030752.1_23526001_3 - 2.1e-08 34.2 0.0 0.00028 21.0 0.0 2.8 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001030752.1_23526001_3 - 0.00013 20.9 0.2 0.00049 19.0 0.0 1.9 3 0 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Sema PF01403.17 204243.1_23525001_3 - 1.1e-148 495.4 0.0 1.9e-148 494.6 0.0 1.4 1 0 0 1 1 1 1 Sema domain Ig_3 PF13927.4 204243.1_23525001_3 - 5.5e-06 26.8 0.2 3.3e-05 24.3 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 204243.1_23525001_3 - 1.2e-05 25.2 0.3 3e-05 23.9 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin I-set domain PSI PF01437.23 204243.1_23525001_3 - 0.00078 19.8 7.2 0.0025 18.2 7.2 1.9 1 0 0 1 1 1 1 Plexin repeat Ig_2 PF13895.4 204243.1_23525001_3 - 0.0072 16.5 0.0 0.019 15.1 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 204243.1_23525001_3 - 0.0082 16.2 0.1 0.028 14.4 0.1 1.9 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 204243.1_23525001_3 - 0.019 15.0 0.6 0.31 11.1 0.2 2.9 2 1 0 2 2 2 0 Immunoglobulin V-set domain DUF727 PF05303.10 001008473.1_23525001_1 - 2.4e-30 104.5 0.0 4.5e-30 103.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF727) Hydrolase_4 PF12146.6 001031423.1_23525001_1 - 4.6e-12 45.6 0.0 1.5e-06 27.5 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.19 001031423.1_23525001_1 - 3.4e-06 26.6 0.0 0.00018 21.0 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.18 001031423.1_23525001_1 - 4.9e-06 26.2 0.1 0.018 14.5 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001031423.1_23525001_1 - 7.5e-05 23.3 2.3 0.0017 18.9 0.0 2.5 2 1 1 3 3 3 1 Alpha/beta hydrolase family DLH PF01738.16 001031423.1_23525001_1 - 0.0097 15.3 0.0 0.015 14.7 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.11 001031423.1_23525001_1 - 0.017 14.7 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DUF818 PF05677.10 001031423.1_23525001_1 - 0.032 13.0 0.1 0.046 12.5 0.1 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) UPF0227 PF05728.10 001031423.1_23525001_1 - 0.034 14.0 0.0 0.27 11.0 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Asp2 PF16929.3 001031423.1_23525001_1 - 0.058 12.3 0.0 0.082 11.8 0.0 1.1 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter ACBP PF00887.17 001006356.1_23528001_1 - 2e-26 91.9 0.1 3.6e-26 91.1 0.1 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein Ammonium_transp PF00909.19 001004370.1_23524001_3 - 2.5e-78 263.4 17.9 2.8e-78 263.2 17.9 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family PDZ PF00595.22 001012697.1_23529001_3 - 5.3e-70 231.6 5.3 5.6e-15 55.3 0.0 6.4 6 0 0 6 6 6 6 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001012697.1_23529001_3 - 3.4e-26 91.3 0.1 0.00024 21.2 0.0 6.4 6 0 0 6 6 6 6 PDZ domain WW PF00397.24 001012697.1_23529001_3 - 7e-17 60.9 4.8 2.1e-08 33.8 0.1 2.7 2 0 0 2 2 2 2 WW domain Guanylate_kin PF00625.19 001012697.1_23529001_3 - 6e-10 39.0 0.0 1.2e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Guanylate kinase MAGI_u1 PF16663.3 001012697.1_23529001_3 - 1.6e-05 24.6 4.7 5.7e-05 22.9 4.7 1.9 1 0 0 1 1 1 1 Unstructured region on MAGI Tricorn_PDZ PF14685.4 001012697.1_23529001_3 - 4.6e-05 23.2 7.3 0.46 10.4 0.1 5.2 6 0 0 6 6 6 2 Tricorn protease PDZ domain PRP3 PF08572.8 001031390.1_23526001_1 - 3.6e-79 265.5 7.1 3.6e-79 265.5 7.1 2.9 3 1 0 3 3 3 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.10 001031390.1_23526001_1 - 1.7e-48 164.2 1.8 1.7e-48 164.2 1.8 2.1 3 0 0 3 3 3 1 Protein of unknown function (DUF1115) PWI PF01480.15 001031390.1_23526001_1 - 1.9e-13 50.4 0.0 4.5e-13 49.2 0.0 1.7 1 0 0 1 1 1 1 PWI domain TPX2 PF06886.9 001031390.1_23526001_1 - 0.082 13.0 0.4 0.082 13.0 0.4 5.5 5 0 0 5 5 5 0 Targeting protein for Xklp2 (TPX2) B PF02216.14 001031390.1_23526001_1 - 0.091 12.6 0.5 7.3 6.5 0.1 2.6 2 0 0 2 2 2 0 B domain Annexin PF00191.18 206906.1_23523001_1 - 1.3e-85 281.2 15.6 4.7e-22 77.7 0.4 4.1 4 0 0 4 4 4 4 Annexin DUF1792 PF08759.9 206906.1_23523001_1 - 0.0023 17.5 0.4 0.01 15.4 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1792) Myb_DNA-bind_7 PF15963.3 206906.1_23523001_1 - 0.012 15.3 0.7 3.7 7.3 0.0 3.3 2 1 1 3 3 3 0 Myb DNA-binding like TMEM132D_C PF15706.3 206906.1_23523001_2 - 0.067 12.9 0.2 0.12 12.1 0.2 1.3 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Kinesin PF00225.21 001030928.1_23527001_1 - 1.2e-110 369.4 0.0 1.5e-110 369.1 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 001030928.1_23527001_1 - 4.9e-25 88.1 0.0 9.4e-25 87.2 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding ADIP PF11559.6 001030928.1_23527001_1 - 0.096 12.6 0.7 0.34 10.9 0.1 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Avidin PF01382.15 205320.1_23522001_2 - 2.5e-41 140.6 5.5 3.1e-41 140.3 5.5 1.1 1 0 0 1 1 1 1 Avidin family HRM PF02793.20 205320.1_23522001_2 - 0.11 12.7 0.0 0.38 11.0 0.0 1.8 2 0 0 2 2 2 0 Hormone receptor domain Orexin PF02072.13 205320.1_23522001_2 - 0.56 10.0 3.4 0.5 10.2 1.5 1.8 2 0 0 2 2 2 0 Prepro-orexin Filament PF00038.19 205286.1_23524001_1 - 2e-101 339.6 55.1 2.7e-101 339.1 55.1 1.2 1 0 0 1 1 1 1 Intermediate filament protein LTD PF00932.17 205286.1_23524001_1 - 1.2e-18 67.3 0.7 2.4e-18 66.4 0.7 1.5 1 0 0 1 1 1 1 Lamin Tail Domain Jnk-SapK_ap_N PF09744.7 205286.1_23524001_1 - 0.01 15.9 13.3 0.01 15.9 13.3 4.5 2 1 2 4 4 4 0 JNK_SAPK-associated protein-1 Spc7 PF08317.9 205286.1_23524001_1 - 0.047 12.4 54.6 0.059 12.1 14.8 3.8 1 1 3 4 4 4 0 Spc7 kinetochore protein Reo_sigmaC PF04582.10 205286.1_23524001_1 - 0.16 11.2 17.0 0.4 9.9 2.9 3.3 2 2 2 4 4 4 0 Reovirus sigma C capsid protein ATG16 PF08614.9 205286.1_23524001_1 - 1.7 8.6 55.9 1.3 9.0 26.4 3.4 1 1 1 3 3 3 0 Autophagy protein 16 (ATG16) TSC22 PF01166.16 205286.1_23524001_1 - 3.2 8.0 18.8 14 6.0 0.6 4.6 3 2 1 4 4 4 0 TSC-22/dip/bun family GAS PF13851.4 205286.1_23524001_1 - 9.3 5.4 56.5 0.12 11.6 10.0 4.4 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding PUA PF01472.18 201071.1_16122001_3 - 2e-19 69.2 0.1 4.2e-19 68.1 0.1 1.6 1 0 0 1 1 1 1 PUA domain Methyltr_RsmF_N PF17125.3 201071.1_16122001_3 - 0.08 13.3 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of 16S rRNA methyltransferase RsmF KH_1 PF00013.27 131491.2_16126001_3 - 3.9e-57 189.8 8.0 2.5e-15 55.9 0.0 4.5 4 0 0 4 4 4 4 KH domain KH_4 PF13083.4 131491.2_16126001_3 - 4.6e-15 55.1 0.2 0.003 17.3 0.1 4.5 4 0 0 4 4 4 4 KH domain KH_2 PF07650.15 131491.2_16126001_3 - 5.5e-14 51.6 7.3 0.006 16.2 0.5 4.5 4 0 0 4 4 4 4 KH domain RRM_1 PF00076.20 131491.2_16126001_3 - 6.1e-13 48.3 0.0 1.1e-06 28.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_5 PF13184.4 131491.2_16126001_3 - 1.1e-06 28.5 3.9 1.1 9.3 0.1 4.1 4 0 0 4 4 4 3 NusA-like KH domain RRM_5 PF13893.4 131491.2_16126001_3 - 0.00079 18.9 0.0 1.1 8.8 0.0 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MOEP19 PF16005.3 131491.2_16126001_3 - 0.0055 16.6 0.0 6 6.8 0.0 3.6 4 0 0 4 4 4 1 KH-like RNA-binding domain zf-U11-48K PF05253.10 131491.2_16126001_3 - 0.6 10.0 2.2 0.62 9.9 0.5 1.9 2 0 0 2 2 2 0 U11-48K-like CHHC zinc finger PH PF00169.27 001134648.1_23526001_1 - 2.3e-26 92.2 1.6 1.2e-12 48.2 0.9 2.6 2 0 0 2 2 2 2 PH domain PH_11 PF15413.4 001134648.1_23526001_1 - 1.6e-05 25.2 2.6 0.027 14.8 0.0 4.0 3 1 0 3 3 3 2 Pleckstrin homology domain PH_9 PF15410.4 001134648.1_23526001_1 - 7.1e-05 23.0 1.0 1.4 9.1 0.4 4.0 2 2 0 2 2 2 2 Pleckstrin homology domain Sharpin_PH PF16764.3 001134648.1_23526001_1 - 0.044 13.5 0.3 0.15 11.7 0.0 1.9 2 0 0 2 2 2 0 Sharpin PH domain TelA PF05816.9 001134648.1_23526001_1 - 0.091 11.7 5.4 0.15 11.0 5.4 1.2 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) Prefoldin_2 PF01920.18 001134648.1_23526001_1 - 1.6 8.6 19.8 2.9 7.8 7.3 2.9 1 1 1 2 2 2 0 Prefoldin subunit APG6 PF04111.10 001134648.1_23526001_1 - 2.4 7.3 13.0 5.5 6.1 13.0 1.5 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.12 001134648.1_23526001_1 - 5.9 6.5 16.2 0.48 10.0 11.3 1.6 2 0 0 2 2 2 0 IncA protein SNF2_N PF00176.21 204941.1_23529001_3 - 3.1e-66 223.4 0.5 6e-66 222.4 0.5 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.22 204941.1_23529001_3 - 8.6e-28 95.9 7.6 2.7e-17 62.2 0.1 3.7 4 0 0 4 4 4 2 Chromo (CHRromatin Organisation MOdifier) domain DUF4208 PF13907.4 204941.1_23529001_3 - 9.1e-27 93.2 2.6 9.1e-27 93.2 2.6 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4208) Helicase_C PF00271.29 204941.1_23529001_3 - 5.2e-20 71.8 0.0 1.3e-19 70.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CHDCT2 PF08074.9 204941.1_23529001_3 - 0.00028 21.0 0.1 0.00028 21.0 0.1 2.7 2 0 0 2 2 2 1 CHDCT2 (NUC038) domain Bcl-2 PF00452.17 204522.1_23522001_1 - 3.8e-22 78.6 0.0 5e-22 78.2 0.0 1.1 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family IRF PF00605.15 205196.1_23525001_3 - 8.7e-42 141.5 1.1 1.7e-41 140.6 1.1 1.5 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor wnt PF00110.17 001037274.1_23523001_1 - 1.3e-123 412.3 26.1 1.5e-123 412.1 26.1 1.0 1 0 0 1 1 1 1 wnt family Amino_oxidase PF01593.22 001015061.2_16125001_1 - 4.5e-17 62.3 0.0 1.6e-16 60.5 0.0 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 001015061.2_16125001_1 - 4.5e-16 58.7 0.1 1e-15 57.6 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.22 001015061.2_16125001_1 - 6.6e-09 35.2 0.5 2.3e-06 26.8 0.7 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.22 001015061.2_16125001_1 - 6.9e-06 25.8 1.3 5.9e-05 22.7 0.8 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.5 001015061.2_16125001_1 - 0.00047 19.5 0.9 0.002 17.5 1.1 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.12 001015061.2_16125001_1 - 0.0025 17.0 0.0 0.004 16.3 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.17 001015061.2_16125001_1 - 0.003 16.8 1.9 0.0045 16.2 1.9 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.15 001015061.2_16125001_1 - 0.0052 15.9 0.1 0.009 15.1 0.1 1.2 1 0 0 1 1 1 1 Thi4 family GDI PF00996.16 001015061.2_16125001_1 - 0.0053 15.2 0.2 0.22 9.9 0.1 2.3 2 0 0 2 2 2 1 GDP dissociation inhibitor MCRA PF06100.9 001015061.2_16125001_1 - 0.0091 14.7 0.0 0.012 14.3 0.0 1.1 1 0 0 1 1 1 1 MCRA family Pyr_redox PF00070.25 001015061.2_16125001_1 - 0.035 14.5 0.7 0.072 13.5 0.7 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.12 001015061.2_16125001_1 - 0.11 11.0 1.1 0.33 9.4 1.4 1.6 2 0 0 2 2 2 0 HI0933-like protein zf-CCCH_2 PF14608.4 001012586.2_23526001_1 - 2.2e-17 62.7 57.8 0.00015 22.0 7.5 5.4 5 0 0 5 5 5 5 RNA-binding, Nab2-type zinc finger PWI PF01480.15 001012586.2_23526001_1 - 0.056 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 PWI domain JmjC PF02373.20 001012862.1_23529001_3 - 2.5e-32 111.6 0.5 9.6e-32 109.7 0.2 2.2 2 0 0 2 2 2 1 JmjC domain, hydroxylase ARID PF01388.19 001012862.1_23529001_3 - 1.1e-12 48.3 0.0 3.4e-12 46.7 0.0 1.9 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.15 001012862.1_23529001_3 - 1.4e-12 47.2 0.1 4.2e-12 45.7 0.1 1.9 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.14 001012862.1_23529001_3 - 3.1e-08 33.7 7.1 9.6e-08 32.1 7.1 1.9 1 0 0 1 1 1 1 C5HC2 zinc finger zf-C3HC4_2 PF13923.4 001012862.1_23529001_3 - 8.8 6.1 7.9 26 4.6 7.9 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PH PF00169.27 204205.1_23526001_1 - 2.9e-26 91.9 1.6 1.3e-12 48.0 0.9 2.6 2 0 0 2 2 2 2 PH domain PH_11 PF15413.4 204205.1_23526001_1 - 2.3e-05 24.6 2.6 0.03 14.6 0.0 3.9 3 1 0 3 3 3 2 Pleckstrin homology domain PH_9 PF15410.4 204205.1_23526001_1 - 9.3e-05 22.7 0.8 1.6 9.0 0.4 4.0 2 2 0 2 2 2 2 Pleckstrin homology domain IncA PF04156.12 204205.1_23526001_1 - 0.013 15.1 7.6 0.034 13.8 7.6 1.6 1 0 0 1 1 1 0 IncA protein Sharpin_PH PF16764.3 204205.1_23526001_1 - 0.052 13.2 0.3 0.17 11.6 0.0 1.9 2 0 0 2 2 2 0 Sharpin PH domain TelA PF05816.9 204205.1_23526001_1 - 0.1 11.5 5.4 0.17 10.8 5.4 1.2 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) APG6 PF04111.10 204205.1_23526001_1 - 1.4 8.1 12.0 3.1 7.0 12.0 1.5 1 0 0 1 1 1 0 Autophagy protein Apg6 Prefoldin_2 PF01920.18 204205.1_23526001_1 - 2.1 8.2 19.7 3.2 7.6 7.3 2.9 1 1 1 2 2 2 0 Prefoldin subunit Interferon PF00143.17 205427.1_23522001_1 - 1.5e-39 135.6 2.2 1.9e-39 135.3 2.2 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain Sgf11 PF08209.9 205427.1_23522001_1 - 0.098 12.1 0.0 0.24 10.9 0.0 1.6 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) PAS_11 PF14598.4 204133.1_23527001_3 - 4.4e-26 91.1 0.2 5.5e-23 81.1 0.1 2.3 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.10 204133.1_23527001_3 - 6.3e-23 80.7 0.0 8.1e-16 58.0 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 204133.1_23527001_3 - 2.7e-22 78.8 0.0 2.7e-10 40.1 0.0 2.7 2 1 0 2 2 2 2 PAS fold HLH PF00010.24 204133.1_23527001_3 - 3.7e-15 55.5 2.3 9.1e-15 54.2 2.3 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 204133.1_23527001_3 - 2.3e-12 47.0 0.0 1.1e-06 28.7 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 204133.1_23527001_3 - 9e-06 25.8 0.0 0.013 15.6 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_2 PF08446.9 204133.1_23527001_3 - 0.043 14.3 0.0 0.12 12.9 0.0 1.7 2 0 0 2 2 2 0 PAS fold ARL2_Bind_BART PF11527.6 001007970.1_23526001_1 - 1.4e-32 112.1 8.8 2e-32 111.6 8.8 1.2 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART PH PF00169.27 200628.1_16123001_2 - 2.9e-18 66.2 1.8 6.7e-18 65.0 1.8 1.7 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.26 200628.1_16123001_2 - 1.4e-11 43.7 0.2 3.5e-11 42.4 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 200628.1_16123001_2 - 5.9e-11 41.8 0.1 1.1e-10 40.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 200628.1_16123001_2 - 4e-09 36.1 0.2 9e-09 34.9 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.4 200628.1_16123001_2 - 3.8e-06 27.1 2.5 1.1e-05 25.6 2.5 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.4 200628.1_16123001_2 - 1.2e-05 25.5 0.4 3.1e-05 24.2 0.4 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain Kinesin PF00225.21 204975.1_23529001_1 - 3.1e-115 384.5 0.0 3.1e-115 384.5 0.0 2.6 2 1 1 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.3 204975.1_23529001_1 - 4.1e-23 81.9 0.0 4.1e-23 81.9 0.0 3.7 5 0 0 5 5 5 1 Microtubule binding Sulfotransfer_1 PF00685.25 204545.1_23523001_3 - 1e-87 293.9 0.0 1.2e-87 293.7 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 204545.1_23523001_3 - 0.0001 22.6 0.1 0.015 15.5 0.1 2.5 2 0 0 2 2 2 2 Sulfotransferase family DUF4060 PF13269.4 204545.1_23523001_3 - 0.079 13.0 0.1 19 5.4 0.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF4060) NIF PF03031.16 001012772.1_23528001_3 - 8.6e-55 184.7 1.0 1.5e-54 183.9 1.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase 7tm_1 PF00001.19 001030765.1_23523001_1 - 1.6e-74 250.4 7.0 2.2e-74 250.0 7.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001030765.1_23523001_1 - 1.2e-06 28.4 3.6 1.2e-06 28.4 3.6 2.5 3 0 0 3 3 3 1 Olfactory receptor CSN8_PSD8_EIF3K PF10075.7 001017583.1_16122001_1 - 1.1e-37 129.1 0.0 1.7e-37 128.4 0.0 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family BRO1 PF03097.16 201178.1_16125001_2 - 4.9e-89 298.7 0.4 7.3e-89 298.1 0.4 1.2 1 0 0 1 1 1 1 BRO1-like domain HR1 PF02185.14 201178.1_16125001_2 - 4.6e-15 55.3 5.3 4.6e-15 55.3 5.3 2.1 2 0 0 2 2 2 1 Hr1 repeat PDZ PF00595.22 201178.1_16125001_2 - 3.9e-06 27.0 0.0 9.1e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 201178.1_16125001_2 - 0.014 15.6 0.0 0.031 14.5 0.0 1.6 1 0 0 1 1 1 0 PDZ domain HTH_12 PF08461.8 201178.1_16125001_2 - 0.19 11.6 1.3 0.56 10.1 1.3 1.8 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain HMG_box PF00505.17 204731.1_23524001_1 - 5.7e-26 90.6 1.3 1.4e-25 89.4 1.3 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box Sox_N PF12444.6 204731.1_23524001_1 - 2e-24 86.4 0.2 2e-24 86.4 0.2 3.7 3 2 0 3 3 3 1 Sox developmental protein N terminal HMG_box_2 PF09011.8 204731.1_23524001_1 - 7.3e-11 42.4 1.5 1.3e-10 41.6 0.6 1.8 2 0 0 2 2 2 1 HMG-box domain Lactamase_B_6 PF16661.3 001031100.1_23527001_1 - 2.6e-15 56.2 0.4 1e-13 51.0 0.1 2.9 3 0 0 3 3 3 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.6 001031100.1_23527001_1 - 7.1e-07 29.4 0.0 1.4e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Beta-Casp domain Beta_lactamase3 PF17030.3 001031100.1_23527001_1 - 0.019 14.0 0.0 0.034 13.2 0.0 1.3 1 0 0 1 1 1 0 Putative beta-lactamase-like family SH2 PF00017.22 204908.1_23525001_1 - 5.2e-11 42.3 0.1 1.9e-10 40.5 0.0 2.0 2 0 0 2 2 2 1 SH2 domain Caldesmon PF02029.13 204158.1_23529001_1 - 2e-147 491.8 211.3 1.1e-119 400.3 139.5 3.9 2 1 1 3 3 3 2 Caldesmon zf-RanBP PF00641.16 001031297.1_23525001_3 - 3.5e-10 38.9 21.1 1.2e-06 27.6 3.7 3.0 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others DUF35_N PF12172.6 001031297.1_23525001_3 - 0.012 15.3 5.8 0.57 10.0 0.2 2.6 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Mem_trans PF03547.16 001031297.1_23525001_3 - 3.8 5.7 5.5 8.2 4.6 5.5 1.6 1 1 0 1 1 1 0 Membrane transport protein Slu7 PF11708.6 001007367.1_16124001_1 - 2.6e-108 361.7 14.4 2.6e-108 361.7 14.4 2.6 3 0 0 3 3 3 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.4 001007367.1_16124001_1 - 0.028 14.0 0.1 0.069 12.7 0.1 1.7 1 0 0 1 1 1 0 Zinc knuckle DUF2744 PF10910.6 001007367.1_16124001_1 - 7.1 6.5 8.2 6 6.7 0.5 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2744) DUF719 PF05334.11 001007367.1_16124001_1 - 9.6 6.2 15.5 0.029 14.4 3.5 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF719) ADK PF00406.20 001020644.1_16126001_1 - 2.4e-45 154.2 0.0 8.5e-26 90.7 0.0 2.2 2 0 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.4 001020644.1_16126001_1 - 1.9e-22 80.0 0.0 7.3e-10 39.3 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.4 001020644.1_16126001_1 - 3.6e-08 33.8 0.0 0.00015 22.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA PF00004.27 001020644.1_16126001_1 - 5.3e-07 30.0 0.0 0.00099 19.4 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) KTI12 PF08433.8 001020644.1_16126001_1 - 0.00014 21.2 0.0 0.00072 18.9 0.0 2.0 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_33 PF13671.4 001020644.1_16126001_1 - 0.00031 20.8 0.0 0.0021 18.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain Hydin_ADK PF17213.1 001020644.1_16126001_1 - 0.0033 17.6 0.1 9.5 6.3 0.0 3.9 4 0 0 4 4 4 1 Hydin Adenylate kinase-like domain RuvB_N PF05496.10 001020644.1_16126001_1 - 0.0053 15.9 0.0 2.8 7.0 0.0 2.2 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus Thymidylate_kin PF02223.15 001020644.1_16126001_1 - 0.024 14.2 0.1 6.3 6.3 0.0 4.0 5 0 0 5 5 5 0 Thymidylate kinase Dpy-30 PF05186.11 001020644.1_16126001_1 - 0.026 14.1 0.0 0.062 12.9 0.0 1.6 1 0 0 1 1 1 0 Dpy-30 motif AAA_5 PF07728.12 001020644.1_16126001_1 - 0.036 13.9 0.1 4.8 7.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Neur_chan_memb PF02932.14 204819.1_23524001_1 - 1.3e-91 306.8 2.2 1.7e-91 306.4 2.2 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 204819.1_23524001_1 - 2.5e-71 239.4 2.2 4.1e-71 238.7 2.2 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF2417 PF10329.7 204819.1_23524001_1 - 0.027 13.8 6.0 0.04 13.2 3.9 2.0 2 0 0 2 2 2 0 Region of unknown function (DUF2417) Phage_HK97_TLTM PF06120.9 204819.1_23524001_1 - 0.17 10.9 0.1 0.25 10.4 0.1 1.1 1 0 0 1 1 1 0 Tail length tape measure protein SMAP PF15477.4 204758.1_23522001_1 - 3.9e-12 46.8 3.8 3.9e-12 46.8 3.8 2.3 2 0 0 2 2 2 1 Small acidic protein family CAP_GLY PF01302.23 204942.1_23529001_1 - 3.7e-47 158.1 3.3 1.1e-23 82.9 0.4 2.3 2 0 0 2 2 2 2 CAP-Gly domain CLIP1_ZNF PF16641.3 204942.1_23529001_1 - 6.6e-15 54.4 20.6 6.8e-09 35.2 4.1 2.5 2 0 0 2 2 2 2 CLIP1 zinc knuckle Kinetocho_Slk19 PF12709.5 204942.1_23529001_1 - 0.0084 16.4 5.4 0.0084 16.4 5.4 15.7 6 3 11 18 18 18 3 Central kinetochore-associated Fringe PF02434.14 204947.1_23528001_1 - 1.3e-118 394.9 0.0 1.6e-118 394.5 0.0 1.1 1 0 0 1 1 1 1 Fringe-like HSP90 PF00183.16 206959.1_23526001_1 - 5.2e-242 804.1 31.6 6.7e-242 803.8 31.6 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.24 206959.1_23526001_1 - 1.9e-12 47.6 0.0 4.1e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.4 206959.1_23526001_1 - 1.1e-09 38.2 0.0 3.2e-09 36.6 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CDC45 PF02724.12 206959.1_23526001_1 - 9.2 4.3 14.4 16 3.5 14.4 1.3 1 0 0 1 1 1 0 CDC45-like protein TYW3 PF02676.12 001002611.1_16123001_1 - 7e-59 198.6 1.0 1.3e-58 197.8 1.0 1.4 1 0 0 1 1 1 1 Methyltransferase TYW3 HMG_box PF00505.17 001037680.1_16124001_3 - 2e-28 98.5 4.9 5e-28 97.2 4.9 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001037680.1_16124001_3 - 7.8e-12 45.5 2.9 1.7e-11 44.4 2.9 1.6 1 0 0 1 1 1 1 HMG-box domain SOXp PF12336.6 001037680.1_16124001_3 - 1.5e-05 25.8 1.0 7.9e-05 23.5 1.0 2.0 1 1 0 1 1 1 1 SOX transcription factor 7tm_2 PF00002.22 001004010.1_16124001_3 - 8.8e-79 264.1 22.0 1.4e-78 263.4 22.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001004010.1_16124001_3 - 6.6e-19 67.8 7.3 1.5e-18 66.7 7.3 1.6 1 0 0 1 1 1 1 Hormone receptor domain DEP PF00610.19 001006576.1_23526001_1 - 1.8e-15 56.6 0.5 8.8e-15 54.4 0.0 2.4 3 0 0 3 3 3 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RhoGAP PF00620.25 001006576.1_23526001_1 - 1.3e-06 28.2 0.1 3.9e-06 26.6 0.1 1.8 1 0 0 1 1 1 1 RhoGAP domain Syndecan PF01034.18 001007869.1_23522001_1 - 8.5e-25 86.3 0.2 1.4e-24 85.7 0.2 1.3 1 0 0 1 1 1 1 Syndecan domain Protocadherin PF08374.9 001007869.1_23522001_1 - 0.13 12.1 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Protocadherin DUF2407_C PF13373.4 001007869.1_23522001_1 - 0.13 12.3 0.0 0.65 10.0 0.0 1.9 2 0 0 2 2 2 0 DUF2407 C-terminal domain Sp38 PF07354.10 206987.1_23523001_1 - 1.5e-135 450.2 0.3 1.8e-135 449.9 0.3 1.1 1 0 0 1 1 1 1 Zona-pellucida-binding protein (Sp38) ig PF00047.23 206987.1_23523001_1 - 0.035 14.1 0.0 0.078 13.0 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain NCD3G PF07562.12 206987.1_23523001_1 - 0.14 12.0 5.9 0.39 10.6 5.9 1.7 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR Toxin_5 PF05294.11 206987.1_23523001_1 - 6.3 7.2 11.5 4.1 7.8 1.0 2.7 2 0 0 2 2 2 0 Scorpion short toxin Piwi PF02171.15 001030900.1_23529001_1 - 1.6e-111 372.2 0.0 2.2e-111 371.8 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.3 001030900.1_23529001_1 - 1.1e-31 108.7 0.3 3.5e-31 107.2 0.1 2.0 2 0 0 2 2 2 1 Mid domain of argonaute PAZ PF02170.20 001030900.1_23529001_1 - 9.8e-30 103.0 0.9 1.7e-29 102.3 0.9 1.4 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.3 001030900.1_23529001_1 - 6.4e-25 88.2 0.0 1.4e-24 87.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.8 001030900.1_23529001_1 - 6.7e-23 79.9 0.0 2e-22 78.4 0.0 1.9 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.3 001030900.1_23529001_1 - 7.1e-13 48.6 0.0 1.9e-12 47.2 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 2 domain ATP_bind_3 PF01171.18 200130.1_16124001_1 - 5e-17 62.1 0.0 8.3e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.3 200130.1_16124001_1 - 6.2e-16 57.4 4.3 6.2e-16 57.4 4.3 3.0 3 0 0 3 3 3 1 Zinc-ribbon zf-RING_UBOX PF13445.4 200130.1_16124001_1 - 0.33 10.9 2.9 0.8 9.6 0.7 2.7 3 0 0 3 3 3 0 RING-type zinc-finger AP3D1 PF06375.9 200130.1_16124001_1 - 4 7.6 16.9 6.4 6.9 16.9 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 OAD_gamma PF04277.11 200130.1_16124001_2 - 0.82 10.2 6.8 1.5 9.3 6.8 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain NUDE_C PF04880.11 201344.1_16125001_3 - 1.5e-43 149.2 3.3 1.5e-43 149.2 3.3 2.4 2 0 0 2 2 2 1 NUDE protein, C-terminal conserved region TPR_MLP1_2 PF07926.10 201344.1_16125001_3 - 0.0046 16.9 5.1 0.0046 16.9 5.1 3.2 3 1 1 4 4 3 2 TPR/MLP1/MLP2-like protein Golgin_A5 PF09787.7 201344.1_16125001_3 - 0.011 15.1 20.9 0.018 14.4 20.9 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 PRKG1_interact PF15898.3 201344.1_16125001_3 - 0.012 16.4 8.1 0.012 16.4 8.1 2.9 3 0 0 3 3 2 0 cGMP-dependent protein kinase interacting domain DUF1664 PF07889.10 201344.1_16125001_3 - 0.15 11.9 7.4 0.044 13.6 2.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) KxDL PF10241.7 201344.1_16125001_3 - 0.19 11.9 12.0 0.046 13.8 4.5 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein IncA PF04156.12 201344.1_16125001_3 - 0.21 11.2 33.2 1.1 8.9 15.4 2.7 1 1 0 2 2 2 0 IncA protein DUF4085 PF13315.4 201344.1_16125001_3 - 0.68 9.4 11.2 0.8 9.2 8.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4085) FlaC_arch PF05377.9 201344.1_16125001_3 - 1 9.7 7.3 0.4 11.0 0.3 3.2 3 1 0 4 4 3 0 Flagella accessory protein C (FlaC) DUF3450 PF11932.6 201344.1_16125001_3 - 1.5 7.9 18.1 0.32 10.1 13.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Snapin_Pallidin PF14712.4 201344.1_16125001_3 - 2.3 8.6 15.1 0.3 11.4 7.2 2.7 1 1 1 2 2 2 0 Snapin/Pallidin DUF1640 PF07798.9 201344.1_16125001_3 - 2.7 7.9 14.6 8.5 6.3 14.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) DUF4407 PF14362.4 201344.1_16125001_3 - 2.8 7.1 15.8 1 8.5 13.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Lectin_N PF03954.12 201344.1_16125001_3 - 3.7 7.2 6.5 6.8 6.3 5.0 2.3 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain DUF4164 PF13747.4 201344.1_16125001_3 - 4.9 7.4 21.8 0.28 11.4 3.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) TolA_bind_tri PF16331.3 201344.1_16125001_3 - 5.5 7.0 25.8 0.05 13.5 11.2 3.4 1 1 3 4 4 4 0 TolA binding protein trimerisation GIT_CC PF16559.3 201344.1_16125001_3 - 6.4 6.8 12.4 0.23 11.4 1.1 2.9 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor UDPG_MGDP_dh_N PF03721.12 001012581.1_23528001_3 - 1e-61 207.7 0.0 1.7e-61 206.9 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.13 001012581.1_23528001_3 - 1.7e-35 121.5 0.0 1.3e-34 118.6 0.0 2.2 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.17 001012581.1_23528001_3 - 9e-33 112.2 0.0 2.1e-32 111.0 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain 3HCDH_N PF02737.16 001012581.1_23528001_3 - 0.031 14.0 0.0 0.69 9.6 0.0 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.16 001012581.1_23528001_3 - 0.089 12.9 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain TSP_C PF05735.10 001001755.1_23528001_1 - 1.1e-96 322.4 1.6 1.6e-96 321.8 1.6 1.3 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.16 001001755.1_23528001_1 - 1.6e-55 184.3 140.2 7.3e-12 44.6 15.4 10.3 8 2 2 10 10 10 8 Thrombospondin type 3 repeat TSP_1 PF00090.17 001001755.1_23528001_1 - 5.7e-46 154.4 56.6 5e-17 61.7 8.6 4.8 4 0 0 4 4 4 3 Thrombospondin type 1 domain VWC PF00093.16 001001755.1_23528001_1 - 3.3e-13 49.6 17.0 3.3e-13 49.6 17.0 5.8 5 1 2 7 7 7 1 von Willebrand factor type C domain EGF_3 PF12947.5 001001755.1_23528001_1 - 2.4e-07 30.7 7.2 2.4e-07 30.7 7.2 5.8 6 0 0 6 6 6 2 EGF domain EGF_CA PF07645.13 001001755.1_23528001_1 - 5e-06 26.5 1.9 5e-06 26.5 1.9 5.4 4 0 0 4 4 4 2 Calcium-binding EGF domain Laminin_G_3 PF13385.4 001001755.1_23528001_1 - 0.0019 18.2 1.2 0.34 10.9 0.0 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 001001755.1_23528001_1 - 0.0031 17.7 8.3 0.0031 17.7 8.3 4.8 4 0 0 4 4 4 1 EGF-like domain cEGF PF12662.5 001001755.1_23528001_1 - 0.02 14.7 0.3 0.02 14.7 0.3 5.0 5 0 0 5 5 5 0 Complement Clr-like EGF-like Calsequestrin PF01216.15 204526.1_23525001_3 - 2.8e-217 721.1 22.9 2.8e-217 721.1 22.9 1.7 1 1 1 2 2 2 1 Calsequestrin Thioredoxin_6 PF13848.4 204526.1_23525001_3 - 2.8e-21 76.2 4.2 3e-19 69.6 3.3 2.2 2 0 0 2 2 2 2 Thioredoxin-like domain SDA1 PF05285.10 204526.1_23525001_3 - 0.12 11.6 16.8 0.19 11.0 16.8 1.2 1 0 0 1 1 1 0 SDA1 Aldolase_II PF00596.19 001031547.1_23528001_2 - 1.3e-45 155.5 0.0 1.7e-45 155.1 0.0 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain 14-3-3 PF00244.18 001006289.1_23526001_1 - 2.1e-108 360.8 10.4 2.8e-108 360.4 10.4 1.2 1 0 0 1 1 1 1 14-3-3 protein Virulence_fact PF13769.4 001006289.1_23526001_1 - 1.5 8.9 5.7 0.55 10.3 1.0 2.3 1 1 1 2 2 2 0 Virulence factor TPR_2 PF07719.15 001008437.1_23529001_3 - 1.5e-25 87.1 22.3 0.0012 18.6 0.0 9.6 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.26 001008437.1_23529001_3 - 1.7e-25 87.6 22.5 4.7e-06 26.1 0.0 9.3 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.4 001008437.1_23529001_3 - 5.9e-24 84.2 17.2 6.7e-07 29.6 0.3 6.5 4 2 2 6 6 6 6 Tetratricopeptide repeat DnaJ PF00226.29 001008437.1_23529001_3 - 8.8e-21 73.7 4.9 1.2e-20 73.2 2.2 2.5 2 0 0 2 2 2 1 DnaJ domain TPR_16 PF13432.4 001008437.1_23529001_3 - 3e-19 69.3 17.6 0.00011 22.7 0.4 7.1 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.4 001008437.1_23529001_3 - 2.1e-16 58.5 23.0 0.00052 19.9 0.1 8.3 8 1 1 9 9 8 4 Tetratricopeptide repeat TPR_11 PF13414.4 001008437.1_23529001_3 - 9.3e-15 53.9 18.9 0.0011 18.5 0.2 7.5 7 1 1 8 8 8 4 TPR repeat TPR_9 PF13371.4 001008437.1_23529001_3 - 3.1e-14 52.8 7.8 5.2e-05 23.2 0.4 5.0 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.4 001008437.1_23529001_3 - 4.3e-12 45.6 23.2 0.19 12.5 0.0 9.5 6 3 5 11 11 9 3 Tetratricopeptide repeat TPR_17 PF13431.4 001008437.1_23529001_3 - 1e-11 44.2 2.3 0.0044 17.2 0.0 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.4 001008437.1_23529001_3 - 3e-10 40.1 19.1 0.079 13.1 0.1 6.6 3 2 4 7 7 7 6 Tetratricopeptide repeat TPR_21 PF09976.7 001008437.1_23529001_3 - 5.1e-10 39.3 16.6 7.5e-07 29.0 3.1 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat-like domain ANAPC3 PF12895.5 001008437.1_23529001_3 - 4.7e-09 36.2 19.5 0.00054 20.0 0.3 5.0 2 1 5 7 7 7 6 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.4 001008437.1_23529001_3 - 1.8e-07 31.2 16.3 1.9 9.2 0.2 9.0 8 1 0 8 8 8 2 Tetratricopeptide repeat TPR_20 PF14561.4 001008437.1_23529001_3 - 2.8e-05 24.2 18.9 0.11 12.7 0.2 6.6 4 1 3 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.4 001008437.1_23529001_3 - 0.00018 21.2 13.9 39 4.5 0.0 8.0 7 2 1 8 8 8 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 001008437.1_23529001_3 - 0.0035 17.3 9.3 1.6 8.7 0.5 5.4 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.4 001008437.1_23529001_3 - 1.2 9.0 7.8 14 5.6 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.4 001008437.1_23529001_3 - 3.1 8.1 8.5 15 5.9 0.1 3.8 2 2 3 5 5 5 0 Alkyl sulfatase dimerisation CAF1 PF04857.18 001006454.1_23526001_3 - 9.5e-21 74.2 0.2 1.8e-10 40.4 0.1 2.4 1 1 1 2 2 2 2 CAF1 family ribonuclease Proteasome PF00227.24 205020.1_23522001_2 - 1.2e-52 178.0 0.0 1.5e-52 177.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 205020.1_23522001_2 - 6.8e-11 41.5 0.0 1.2e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature SH3_9 PF14604.4 001003505.1_16124001_2 - 6.4e-16 57.8 0.1 1.8e-12 46.8 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.26 001003505.1_16124001_2 - 7.5e-14 50.9 0.3 2e-13 49.6 0.1 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 001003505.1_16124001_2 - 2.3e-11 43.1 0.1 0.00026 20.5 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain C1_1 PF00130.20 001003505.1_16124001_2 - 4.2e-07 29.6 14.3 1.3e-06 28.1 14.3 1.9 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) STAC2_u1 PF16664.3 001003505.1_16124001_2 - 9.5e-06 26.0 0.3 2.8e-05 24.5 0.3 1.8 1 0 0 1 1 1 1 Unstructured on SH3 and cysteine-rich domain-containing protein 2 PHD PF00628.27 001003505.1_16124001_2 - 0.011 15.4 4.3 0.034 13.9 4.3 1.8 1 0 0 1 1 1 0 PHD-finger Ets PF00178.20 205312.1_23524001_2 - 2.4e-36 123.9 1.1 2.4e-36 123.9 1.1 2.8 4 0 0 4 4 4 1 Ets-domain SAM_PNT PF02198.14 205312.1_23524001_2 - 7.3e-34 115.5 1.0 1.5e-33 114.4 1.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain ADH_zinc_N PF00107.24 001017852.1_16124001_1 - 3.4e-15 56.0 0.0 5.8e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001017852.1_16124001_1 - 6.2e-09 35.6 0.0 1.4e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.4 001017852.1_16124001_1 - 2.7e-06 28.3 0.0 6.7e-06 27.0 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Enolase_C PF00113.20 205120.1_23524001_2 - 3.4e-158 525.4 0.0 4.3e-158 525.1 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.14 205120.1_23524001_2 - 1.6e-61 206.1 0.1 2.5e-61 205.5 0.1 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.4 205120.1_23524001_2 - 2e-07 30.7 0.0 3.2e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.9 205120.1_23524001_2 - 0.0011 18.0 0.3 0.0024 16.9 0.3 1.5 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus ODC_AZ PF02100.15 204916.1_23523001_3 - 1.9e-21 76.0 0.0 3.2e-21 75.3 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Sulfotransfer_2 PF03567.12 204481.1_23525001_3 - 5.3e-40 137.8 0.4 7.5e-40 137.3 0.4 1.2 1 0 0 1 1 1 1 Sulfotransferase family Gal-3-0_sulfotr PF06990.9 204481.1_23525001_3 - 0.00088 18.1 0.0 0.0012 17.6 0.0 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_1 PF00685.25 204481.1_23525001_3 - 0.022 14.1 0.0 0.034 13.5 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase domain OAD_gamma PF04277.11 001017699.1_16122001_2 - 5.4 7.5 6.6 2.7 8.5 3.1 2.0 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Med10 PF09748.7 001017699.1_16122001_3 - 8.5e-36 122.4 0.2 1.1e-35 122.1 0.2 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex LIM_bind PF01803.14 205070.1_23523001_1 - 1.1e-53 182.1 9.3 5.6e-42 143.8 1.5 2.7 2 1 1 3 3 3 2 LIM-domain binding protein Sof1 PF04158.12 001030948.1_23524001_1 - 2.9e-36 123.5 12.1 4.7e-36 122.8 12.1 1.3 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.30 001030948.1_23524001_1 - 4.8e-20 71.4 12.8 0.0004 21.0 0.1 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.9 001030948.1_23524001_1 - 7.1e-06 25.9 0.6 0.00083 19.1 0.0 3.2 2 1 2 4 4 4 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.5 001030948.1_23524001_1 - 3.3e-05 24.0 0.0 0.045 13.9 0.0 3.7 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Cadherin PF00028.15 001004371.1_23529001_1 - 4.2e-81 267.4 4.8 1.3e-18 67.0 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.15 001004371.1_23529001_1 - 6.3e-55 184.9 0.1 9.9e-55 184.3 0.1 1.3 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.3 001004371.1_23529001_1 - 2.6e-05 24.1 3.9 2.5 8.0 0.1 5.2 5 0 0 5 5 5 2 Cadherin-like Cadherin_2 PF08266.10 001004371.1_23529001_1 - 0.00037 20.1 0.0 0.11 12.1 0.0 3.2 3 0 0 3 3 3 1 Cadherin-like ASFV_J13L PF05568.9 001004371.1_23529001_1 - 0.05 13.2 0.0 0.091 12.4 0.0 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF4286 PF14114.4 001004371.1_23529001_1 - 0.12 12.7 0.0 0.33 11.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4286) Serinc PF03348.13 213514.1_16125001_2 - 1.1e-152 508.8 34.7 1.3e-152 508.6 34.7 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) CAF1C_H4-bd PF12265.6 212595.1_16125001_3 - 3.1e-28 97.7 0.3 1.4e-27 95.5 0.1 2.2 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.30 212595.1_16125001_3 - 1.8e-24 85.4 16.8 2.1e-06 28.2 0.0 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 212595.1_16125001_3 - 0.00028 21.0 0.5 0.027 14.6 0.0 3.2 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain BLM_N PF16202.3 001007087.1_23529001_1 - 4.5e-30 104.9 0.9 1.4e-11 44.0 0.0 3.9 3 0 0 3 3 3 3 N-terminal region of Bloom syndrome protein BDHCT PF08072.9 001007087.1_23529001_1 - 2.7e-21 75.2 1.8 8.9e-21 73.6 1.8 2.0 1 0 0 1 1 1 1 BDHCT (NUC031) domain DEAD PF00270.27 001007087.1_23529001_1 - 8.1e-20 71.2 0.0 1.6e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.3 001007087.1_23529001_1 - 2.8e-18 66.2 1.8 9.9e-18 64.5 1.8 2.0 1 0 0 1 1 1 1 RecQ zinc-binding Helicase_C PF00271.29 001007087.1_23529001_1 - 6.1e-16 58.7 0.0 2.1e-15 56.9 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RQC PF09382.8 001007087.1_23529001_1 - 1.3e-13 50.6 0.1 2.5e-13 49.7 0.1 1.5 1 0 0 1 1 1 1 RQC domain HRDC PF00570.21 001007087.1_23529001_1 - 1.2e-12 47.5 0.0 2.5e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 HRDC domain BDHCT_assoc PF16204.3 001007087.1_23529001_1 - 0.00042 19.9 0.0 0.00097 18.7 0.0 1.7 1 0 0 1 1 1 1 BDHCT-box associated domain on Bloom syndrome protein ResIII PF04851.13 001007087.1_23529001_1 - 0.014 15.2 0.0 0.029 14.2 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit SNF2_N PF00176.21 001007087.1_23529001_1 - 0.019 13.6 0.0 0.14 10.7 0.0 2.0 2 0 0 2 2 2 0 SNF2 family N-terminal domain SMC_N PF02463.17 205230.1_23529001_1 - 4.8e-56 189.5 54.3 3.6e-55 186.6 54.3 2.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.11 205230.1_23529001_1 - 2.3e-22 79.4 0.1 2.3e-22 79.4 0.1 2.7 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.4 205230.1_23529001_1 - 8e-09 35.6 16.6 3.9e-05 23.5 1.0 3.0 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.4 205230.1_23529001_1 - 1.1e-05 25.1 41.7 1.1e-05 25.1 41.7 4.5 2 2 1 3 3 3 1 AAA ATPase domain AAA_29 PF13555.4 205230.1_23529001_1 - 0.00041 19.9 0.0 0.001 18.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF4200 PF13863.4 205230.1_23529001_1 - 0.0029 17.8 21.6 0.0029 17.8 21.6 8.5 4 2 2 7 7 7 3 Domain of unknown function (DUF4200) Reo_sigmaC PF04582.10 205230.1_23529001_1 - 2.6 7.2 31.3 0.44 9.8 1.6 4.6 2 2 2 4 4 4 0 Reovirus sigma C capsid protein VWA PF00092.26 204937.1_23524001_3 - 3.5e-82 274.8 0.1 5.3e-41 140.6 0.1 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.4 204937.1_23524001_3 - 7.5e-27 94.0 0.0 2e-12 47.6 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain LCCL PF03815.17 204937.1_23524001_3 - 3.4e-22 78.2 0.0 9.1e-22 76.9 0.0 1.7 1 0 0 1 1 1 1 LCCL domain VWA_3 PF13768.4 204937.1_23524001_3 - 7.3e-05 22.6 0.0 0.17 11.7 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain Rxt3 PF08642.8 204937.1_23524001_3 - 0.18 12.5 0.0 0.47 11.1 0.0 1.7 1 1 0 1 1 1 0 Histone deacetylation protein Rxt3 Neur_chan_memb PF02932.14 204815.2_23524001_2 - 1.7e-100 335.8 0.0 2.3e-100 335.5 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 204815.2_23524001_2 - 1.6e-80 269.5 4.6 2.2e-80 269.0 4.6 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain PTPRCAP PF15713.3 204815.2_23524001_2 - 0.07 13.3 6.8 0.12 12.5 6.8 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated eIF3_subunit PF08597.8 204815.2_23524001_2 - 0.21 11.4 5.5 0.38 10.5 5.5 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit CENP-B_dimeris PF09026.8 204815.2_23524001_2 - 2.3 8.6 5.5 4.9 7.5 5.5 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2417 PF10329.7 204815.2_23524001_2 - 7 5.9 13.2 2.2 7.5 9.9 1.8 2 0 0 2 2 2 0 Region of unknown function (DUF2417) OST3_OST6 PF04756.11 001006435.1_23526001_2 - 6.5e-105 350.5 0.0 8.6e-105 350.1 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.18 001006435.1_23526001_2 - 3.5e-05 23.6 0.0 6.2e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Hydrolase_4 PF12146.6 001007826.1_23525001_1 - 1.8e-12 47.0 0.0 1.1e-06 28.0 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.5 001007826.1_23525001_1 - 3.9e-06 27.5 0.0 0.0011 19.5 0.0 2.3 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 001007826.1_23525001_1 - 5.5e-06 26.1 0.1 0.064 12.8 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 001007826.1_23525001_1 - 8.6e-06 25.2 0.0 0.00014 21.3 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.16 001007826.1_23525001_1 - 0.0046 16.4 0.0 0.0072 15.8 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family DUF818 PF05677.10 001007826.1_23525001_1 - 0.005 15.7 0.1 0.0077 15.1 0.1 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) UPF0227 PF05728.10 001007826.1_23525001_1 - 0.0076 16.1 0.0 0.05 13.4 0.0 1.9 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0227) Abhydrolase_5 PF12695.5 001007826.1_23525001_1 - 0.012 15.2 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family FSH1 PF03959.11 001007826.1_23525001_1 - 0.021 14.3 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Asp2 PF16929.3 001007826.1_23525001_1 - 0.069 12.1 0.0 0.099 11.6 0.0 1.1 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter Abhydrolase_2 PF02230.14 001007826.1_23525001_1 - 0.076 12.7 0.0 0.27 10.9 0.0 1.8 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase V-set_2 PF15910.3 205311.1_23522001_1 - 1.3e-09 38.1 0.1 1.9e-09 37.5 0.1 1.3 1 0 0 1 1 1 1 ICOS V-set domain V-set PF07686.15 205311.1_23522001_1 - 1.9e-05 24.6 0.1 3.5e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain TMEM119 PF15724.3 205311.1_23522001_1 - 0.15 11.9 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 TMEM119 family OLF PF02191.14 204767.1_23525001_3 - 1.2e-88 296.7 7.7 1.7e-88 296.2 7.7 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.6 204767.1_23525001_3 - 2.7e-48 161.9 9.6 2.7e-47 158.7 5.2 2.7 3 0 0 3 3 3 1 Neurogenesis glycoprotein APG17 PF04108.10 204767.1_23525001_3 - 0.00059 18.9 3.3 0.001 18.2 3.3 1.3 1 0 0 1 1 1 1 Autophagy protein Apg17 IncA PF04156.12 204767.1_23525001_3 - 0.0016 18.1 12.9 0.0029 17.3 12.9 1.4 1 0 0 1 1 1 1 IncA protein Helo_like_N PF17111.3 204767.1_23525001_3 - 0.0023 17.2 0.7 0.0023 17.2 0.7 2.4 1 1 1 2 2 2 1 Fungal N-terminal domain of STAND proteins zf-C4H2 PF10146.7 204767.1_23525001_3 - 0.008 16.4 1.2 0.012 15.8 1.2 1.2 1 0 0 1 1 1 1 Zinc finger-containing protein Baculo_PEP_C PF04513.10 204767.1_23525001_3 - 0.022 14.6 1.7 0.12 12.3 0.6 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Lipoprotein_7 PF01540.14 204767.1_23525001_3 - 0.023 13.9 2.0 0.034 13.3 2.0 1.1 1 0 0 1 1 1 0 Adhesin lipoprotein DUF4795 PF16043.3 204767.1_23525001_3 - 0.069 12.6 10.6 0.27 10.7 10.6 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) Reo_sigmaC PF04582.10 204767.1_23525001_3 - 0.074 12.3 0.2 0.11 11.7 0.2 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Xpo1 PF08389.10 204767.1_23525001_3 - 0.095 12.6 1.2 0.17 11.8 0.4 1.7 1 1 0 1 1 1 0 Exportin 1-like protein NPV_P10 PF05531.10 204767.1_23525001_3 - 0.26 11.7 3.2 9.2 6.7 3.2 3.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein TBCC_N PF16752.3 204767.1_23525001_3 - 0.28 11.5 11.8 0.21 11.9 8.2 2.3 1 1 2 3 3 3 0 Tubulin-specific chaperone C N-terminal domain BLOC1_2 PF10046.7 204767.1_23525001_3 - 0.3 11.3 11.3 14 6.0 0.5 3.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Exonuc_VII_L PF02601.13 204767.1_23525001_3 - 0.38 10.1 6.7 0.62 9.4 6.7 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.10 204767.1_23525001_3 - 0.51 10.2 9.3 3.7 7.4 4.5 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.7 204767.1_23525001_3 - 0.53 9.2 10.2 0.88 8.5 10.2 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CENP-Q PF13094.4 204767.1_23525001_3 - 0.55 10.3 13.3 1.6 8.8 13.5 1.5 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Syntaxin_2 PF14523.4 204767.1_23525001_3 - 0.66 10.3 10.3 16 5.8 9.5 2.5 1 1 0 1 1 1 0 Syntaxin-like protein FUSC PF04632.10 204767.1_23525001_3 - 1.9 6.8 3.7 2.8 6.2 3.7 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family CLZ PF16526.3 204767.1_23525001_3 - 1.9 8.7 14.0 3 8.1 4.3 3.2 2 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF310 PF03750.11 204767.1_23525001_3 - 2.1 9.1 8.3 8.3 7.1 4.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF310) PriC PF07445.10 204767.1_23525001_3 - 2.3 8.0 13.4 0.97 9.2 7.2 2.2 2 0 0 2 2 2 0 Primosomal replication protein priC Laminin_II PF06009.10 204767.1_23525001_3 - 2.4 8.1 8.3 1.2 9.0 3.5 2.3 1 1 1 2 2 2 0 Laminin Domain II ABC_tran_CTD PF16326.3 204767.1_23525001_3 - 4.3 7.5 14.5 1 9.5 2.8 3.6 1 1 3 4 4 4 0 ABC transporter C-terminal domain H-kinase_dim PF02895.12 204767.1_23525001_3 - 5.5 7.3 7.6 84 3.5 7.6 2.5 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain Nup54 PF13874.4 204767.1_23525001_3 - 9 6.3 11.6 23 4.9 11.1 2.0 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 MIP-T3 PF10243.7 200600.1_16125001_1 - 9.8e-184 611.9 80.4 1.1e-183 611.7 80.4 1.0 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 RRM_3 PF08777.9 199930.2_16124001_2 - 1.4e-31 108.4 0.0 1.4e-31 108.4 0.0 3.9 4 1 1 5 5 5 2 RNA binding motif RRM_1 PF00076.20 199930.2_16124001_2 - 7.8e-21 73.5 0.0 4.3e-17 61.6 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) La PF05383.15 199930.2_16124001_2 - 2.5e-20 72.1 0.2 7.7e-20 70.6 0.2 1.9 1 0 0 1 1 1 1 La domain Nup35_RRM_2 PF14605.4 199930.2_16124001_2 - 0.0039 17.0 0.0 0.013 15.4 0.0 1.8 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif GUCT PF08152.10 199930.2_16124001_2 - 0.24 11.5 2.6 0.34 11.1 0.8 2.2 2 0 0 2 2 2 0 GUCT (NUC152) domain CN_hydrolase PF00795.20 001006465.1_23526001_1 - 8e-49 166.2 0.0 1.1e-48 165.8 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.15 001006465.1_23526001_1 - 1.1e-26 93.3 0.0 2.5e-26 92.1 0.0 1.6 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.19 001006465.1_23526001_1 - 0.018 14.5 0.0 0.031 13.8 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase Sugar_tr PF00083.22 205209.1_23527001_2 - 9.2e-156 519.1 23.6 1.3e-155 518.6 23.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 205209.1_23527001_2 - 5.6e-19 68.2 32.9 2.7e-17 62.6 27.2 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Pox_EPC_I2-L1 PF12575.6 205209.1_23527001_2 - 3.6 7.7 5.9 2.8 8.1 3.2 2.3 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 RNase_T PF00929.22 001020640.1_16125001_3 - 9.2e-26 91.2 0.0 2.1e-25 90.0 0.0 1.6 1 0 0 1 1 1 1 Exonuclease zf-GRF PF06839.10 001020640.1_16125001_3 - 2.3e-14 53.1 4.3 2.3e-14 53.1 4.3 2.1 2 0 0 2 2 2 1 GRF zinc finger Tnp_DNA_bind PF14706.4 001020640.1_16125001_3 - 0.024 14.3 0.0 0.056 13.2 0.0 1.6 1 0 0 1 1 1 0 Transposase DNA-binding RRM_1 PF00076.20 001013345.1_16122001_2 - 1e-18 66.7 0.0 2.2e-18 65.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 001013345.1_16122001_2 - 0.00016 21.5 0.1 0.00039 20.3 0.0 1.6 2 0 0 2 2 2 1 RNA binding motif RRM_5 PF13893.4 001013345.1_16122001_2 - 0.0028 17.1 0.0 0.0046 16.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 001013345.1_16122001_2 - 0.092 12.6 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif ADH_zinc_N_2 PF13602.4 001007051.3_16129001_1 - 1.7e-19 71.0 0.0 2.9e-19 70.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.24 001007051.3_16129001_1 - 4.2e-16 58.9 0.0 7.9e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001007051.3_16129001_1 - 1.5e-10 40.8 0.6 2.8e-10 39.9 0.1 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain CAF1 PF04857.18 001007051.3_16129001_1 - 0.0018 17.4 3.0 0.022 13.8 0.3 2.4 3 0 0 3 3 3 1 CAF1 family ribonuclease DDHD PF02862.15 001007051.3_16129001_1 - 0.025 14.6 9.0 0.012 15.7 2.4 2.1 2 0 0 2 2 2 0 DDHD domain RNA_pol_Rpc4 PF05132.12 001007051.3_16129001_1 - 0.13 12.6 24.9 1.6 9.0 1.6 2.6 2 0 0 2 2 2 0 RNA polymerase III RPC4 GCSF PF16647.3 205279.1_23523001_1 - 3.3e-30 104.8 0.6 3.3e-30 104.8 0.6 2.0 3 0 0 3 3 3 1 Granulocyte colony-stimulating factor IL6 PF00489.15 205279.1_23523001_1 - 4.2e-09 36.1 0.0 8.4e-09 35.1 0.0 1.4 1 1 0 1 1 1 1 Interleukin-6/G-CSF/MGF family Period_C PF12114.6 204262.1_23529001_1 - 1.6e-93 311.6 5.6 1.6e-93 311.6 5.6 3.7 3 0 0 3 3 3 1 Period protein 2/3C-terminal region PAS_3 PF08447.10 204262.1_23529001_1 - 1.1e-12 47.9 0.0 4.5e-12 45.9 0.0 2.0 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.4 204262.1_23529001_1 - 1.1e-08 35.1 0.0 4.8e-08 33.0 0.0 2.2 1 0 0 1 1 1 1 PAS domain PAS PF00989.23 204262.1_23529001_1 - 5.2e-06 26.3 0.0 0.00035 20.4 0.0 2.6 2 0 0 2 2 2 1 PAS fold Sema PF01403.17 204242.1_23526001_1 - 4.4e-147 490.1 0.0 6e-147 489.7 0.0 1.2 1 0 0 1 1 1 1 Sema domain V-set PF07686.15 204242.1_23526001_1 - 0.00086 19.3 0.0 0.003 17.5 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.23 204242.1_23526001_1 - 0.0027 17.7 0.0 0.0063 16.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain PSI PF01437.23 204242.1_23526001_1 - 0.0059 17.0 6.4 0.0059 17.0 6.4 2.0 2 0 0 2 2 2 1 Plexin repeat OTCace PF00185.22 204910.1_23523001_1 - 2.1e-51 174.0 0.0 3.1e-51 173.4 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.19 204910.1_23523001_1 - 8e-43 145.7 0.0 1.4e-42 144.9 0.0 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain SEP PF08059.11 001030859.1_23523001_1 - 1.3e-26 92.8 0.3 3.2e-26 91.6 0.1 1.8 2 0 0 2 2 2 1 SEP domain UBX PF00789.18 001030859.1_23523001_1 - 3e-20 72.1 0.1 8e-20 70.7 0.1 1.8 2 0 0 2 2 2 1 UBX domain UBA_4 PF14555.4 001030859.1_23523001_1 - 8.4e-17 60.6 0.4 1.7e-16 59.6 0.4 1.5 1 0 0 1 1 1 1 UBA-like domain Sec1 PF00995.21 001025182.1_16124001_2 - 9.9e-136 454.1 0.3 1.1e-135 453.9 0.3 1.0 1 0 0 1 1 1 1 Sec1 family YlbD_coat PF14071.4 001025182.1_16124001_2 - 0.016 15.3 1.1 0.053 13.6 0.8 2.0 2 0 0 2 2 2 0 Putative coat protein ELO PF01151.16 001031539.1_23527001_2 - 6.1e-68 228.9 25.4 8.8e-68 228.4 25.4 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family Rad52_Rad22 PF04098.13 204546.2_23523001_3 - 4.8e-10 39.4 0.0 8e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein RRM_1 PF00076.20 204546.2_23523001_3 - 7e-06 25.6 0.0 1.3e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 204546.2_23523001_3 - 0.0018 17.7 0.0 0.0032 16.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) vATP-synt_AC39 PF01992.14 001008455.1_23524001_3 - 8.9e-113 377.0 1.2 1e-112 376.8 1.2 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit DUF4749 PF15936.3 001001764.1_23523001_2 - 7.5e-24 84.6 0.7 1.4e-23 83.8 0.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ PF00595.22 001001764.1_23523001_2 - 1.4e-16 60.5 0.0 2.5e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) LIM PF00412.20 001001764.1_23523001_2 - 1.4e-13 50.7 3.1 2.4e-13 50.0 3.1 1.4 1 0 0 1 1 1 1 LIM domain PDZ_2 PF13180.4 001001764.1_23523001_2 - 0.0013 18.8 0.0 0.0025 18.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Lar_restr_allev PF14354.4 001001764.1_23523001_2 - 0.15 12.4 2.2 0.35 11.2 2.2 1.6 1 0 0 1 1 1 0 Restriction alleviation protein Lar UEV PF05743.11 001003619.2_16125001_2 - 4.6e-41 139.3 0.0 7.3e-41 138.7 0.0 1.3 1 0 0 1 1 1 1 UEV domain Ldh_1_N PF00056.21 001003619.2_16125001_2 - 1.4e-19 70.5 0.3 2.2e-19 69.8 0.3 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 001003619.2_16125001_2 - 3.9e-07 30.0 0.0 2.7e-06 27.3 0.0 2.1 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain adh_short PF00106.23 001005837.1_23524001_3 - 4.1e-41 140.5 0.1 5.7e-41 140.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001005837.1_23524001_3 - 3.2e-25 88.9 0.0 4.5e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001005837.1_23524001_3 - 2.6e-07 30.6 0.0 4.2e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.13 001005837.1_23524001_3 - 0.0015 17.6 0.1 0.0047 16.0 0.1 1.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.16 001005837.1_23524001_3 - 0.0019 18.3 0.0 0.0036 17.4 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.19 001005837.1_23524001_3 - 0.039 13.3 0.6 0.13 11.6 0.5 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family ApbA PF02558.14 001005837.1_23524001_3 - 0.14 11.7 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ADP_ribosyl_GH PF03747.12 001006312.1_23526001_3 - 1.1e-61 209.0 0.0 1.5e-61 208.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Requiem_N PF14051.4 204640.1_23523001_1 - 5.4e-35 119.3 0.2 1e-34 118.4 0.2 1.5 1 0 0 1 1 1 1 N-terminal domain of DPF2/REQ. PHD PF00628.27 204640.1_23523001_1 - 2e-21 75.5 21.4 2.1e-12 46.6 4.7 3.7 3 1 1 4 4 4 2 PHD-finger Lar_restr_allev PF14354.4 204640.1_23523001_1 - 0.01 16.0 2.8 0.01 16.0 2.8 4.2 2 1 1 3 3 3 0 Restriction alleviation protein Lar zf-C2H2_4 PF13894.4 204640.1_23523001_1 - 0.07 13.9 1.1 0.07 13.9 1.1 4.8 5 0 0 5 5 5 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 204640.1_23523001_1 - 0.27 11.6 0.2 0.27 11.6 0.2 5.0 6 2 0 6 6 6 0 Zinc-finger double domain Prok-RING_1 PF14446.4 204640.1_23523001_1 - 2.1 8.2 18.4 1.4 8.8 4.4 4.3 4 0 0 4 4 4 0 Prokaryotic RING finger family 1 zf-PHD-like PF15446.4 204640.1_23523001_1 - 2.9 7.3 12.8 0.19 11.2 1.7 2.9 2 1 0 3 3 3 0 PHD/FYVE-zinc-finger like domain PHD_2 PF13831.4 204640.1_23523001_1 - 7.1 6.1 19.5 0.064 12.7 1.4 3.7 3 1 1 4 4 4 0 PHD-finger Kazal_2 PF07648.13 205200.1_23523001_1 - 7.3e-35 118.8 32.2 2e-13 50.2 1.6 4.9 4 1 0 4 4 4 3 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 205200.1_23523001_1 - 2.5e-17 62.5 35.6 1.1e-06 28.4 7.9 4.0 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain FOLN PF09289.8 205200.1_23523001_1 - 1.8e-07 31.1 13.6 1.8e-07 31.1 13.6 4.4 4 0 0 4 4 4 2 Follistatin/Osteonectin-like EGF domain LRR_8 PF13855.4 001020638.1_16126001_3 - 7.5e-12 44.7 9.4 2.7e-10 39.7 7.1 2.7 1 1 1 2 2 2 2 Leucine rich repeat Exo_endo_phos PF03372.21 001020638.1_16126001_3 - 1.5e-09 37.9 0.0 2.3e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.5 001020638.1_16126001_3 - 5.6e-09 36.0 13.7 3e-07 30.5 1.3 3.2 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001020638.1_16126001_3 - 0.067 12.6 2.6 0.23 10.8 2.2 1.8 1 1 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.31 001020638.1_16126001_3 - 5.1 7.8 22.0 18 6.2 0.1 6.0 6 0 0 6 6 6 0 Leucine Rich Repeat fn3 PF00041.19 001012826.2_23528001_3 - 4.6e-88 289.6 0.0 8.7e-11 41.9 0.0 9.8 9 1 0 9 9 9 9 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 001012826.2_23528001_3 - 2.8e-17 63.0 9.3 0.014 15.9 0.1 8.9 9 1 0 9 9 9 6 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 001012826.2_23528001_3 - 2.5e-11 43.8 0.0 0.081 13.3 0.0 6.9 7 0 0 7 7 7 3 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 001012826.2_23528001_3 - 1.1e-05 25.6 3.1 0.064 13.4 0.1 5.5 6 0 0 6 6 6 1 Interferon-alpha/beta receptor, fibronectin type III DUF912 PF06024.10 001012826.2_23528001_3 - 0.058 13.6 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) IL6Ra-bind PF09240.8 001012826.2_23528001_3 - 0.13 12.6 3.4 8.6 6.7 0.3 2.6 2 0 0 2 2 2 0 Interleukin-6 receptor alpha chain, binding WD40 PF00400.30 001007979.1_23527001_3 - 3.2e-39 132.1 7.1 1.6e-07 31.8 0.1 6.9 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001007979.1_23527001_3 - 3.3e-16 59.2 0.1 2.7e-05 24.3 0.0 5.0 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001007979.1_23527001_3 - 2e-12 46.6 0.6 0.0049 15.8 0.1 3.5 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 001007979.1_23527001_3 - 5.2e-08 31.8 0.4 0.0019 16.8 0.1 3.6 2 1 2 4 4 4 2 Nucleoporin Nup120/160 LisH PF08513.9 001007979.1_23527001_3 - 0.043 13.7 0.0 0.087 12.7 0.0 1.5 1 0 0 1 1 1 0 LisH PD40 PF07676.10 001007979.1_23527001_3 - 0.12 12.2 0.0 1.4 8.8 0.0 2.7 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Hira PF07569.9 001007979.1_23527001_3 - 0.29 10.7 4.1 4.1 6.9 0.0 3.8 5 0 0 5 5 5 0 TUP1-like enhancer of split zf-HC5HC2H PF13771.4 001012900.1_23528001_2 - 2.7e-18 65.8 3.5 2.7e-18 65.8 3.5 4.1 3 0 0 3 3 3 1 PHD-like zinc-binding domain HECT PF00632.23 001012900.1_23528001_2 - 2e-08 34.0 0.0 3.4e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) zf-HC5HC2H_2 PF13832.4 001012900.1_23528001_2 - 5.2e-06 26.5 5.4 5.2e-06 26.5 5.4 3.8 2 1 1 3 3 3 1 PHD-zinc-finger like domain CLTH PF10607.7 001012604.1_23525001_1 - 2.9e-31 108.2 0.4 5e-31 107.4 0.4 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Mic1 PF07035.10 001012604.1_23525001_1 - 0.0009 18.9 0.5 0.0024 17.5 0.1 1.9 2 0 0 2 2 2 1 Colon cancer-associated protein Mic1-like LisH PF08513.9 001012604.1_23525001_1 - 0.12 12.3 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 LisH Anoctamin PF04547.10 001030206.1_16126001_3 - 2.8e-119 398.6 19.8 3.3e-119 398.4 19.8 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Translin PF01997.14 205073.1_23522001_2 - 2.7e-57 193.9 0.1 3.2e-57 193.7 0.1 1.1 1 0 0 1 1 1 1 Translin family FlaC_arch PF05377.9 205073.1_23522001_2 - 0.0097 16.1 0.2 8.7 6.7 0.0 3.1 3 0 0 3 3 3 2 Flagella accessory protein C (FlaC) CbbQ_C PF08406.8 205073.1_23522001_2 - 0.099 12.8 0.3 0.6 10.3 0.1 2.2 2 0 0 2 2 2 0 CbbQ/NirQ/NorQ C-terminal eIF2_C PF09173.9 001006260.2_23524001_3 - 5.5e-37 125.8 1.9 7.9e-37 125.3 0.5 2.1 2 0 0 2 2 2 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.25 001006260.2_23524001_3 - 1.9e-22 79.7 0.8 1.4e-21 76.8 0.8 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.23 001006260.2_23524001_3 - 8.2e-13 48.4 0.3 2.5e-12 46.9 0.3 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 001006260.2_23524001_3 - 0.0048 16.8 0.0 0.01 15.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001006260.2_23524001_3 - 0.0055 16.5 0.4 0.04 13.7 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 MMR_HSR1_Xtn PF16897.3 001006260.2_23524001_3 - 0.12 12.3 0.1 0.26 11.2 0.1 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Enolase_C PF00113.20 205119.1_23524001_3 - 7.3e-147 488.2 0.0 9.4e-147 487.8 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.14 205119.1_23524001_3 - 5.8e-60 201.1 0.0 1e-59 200.3 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.4 205119.1_23524001_3 - 1.1e-07 31.6 0.0 2.3e-07 30.6 0.0 1.5 1 1 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.9 205119.1_23524001_3 - 0.0006 18.9 1.9 0.0007 18.7 0.2 1.8 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus I-set PF07679.14 204711.1_23523001_1 - 3.3e-40 135.9 0.9 1.2e-13 50.7 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 204711.1_23523001_1 - 2.2e-39 133.8 2.7 1.5e-14 54.2 0.2 3.3 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 204711.1_23523001_1 - 3e-33 113.7 2.3 1.8e-14 53.5 0.0 4.3 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.4 204711.1_23523001_1 - 5.6e-32 109.8 2.1 4.8e-13 49.1 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 204711.1_23523001_1 - 2.4e-16 59.7 7.5 1.3e-07 31.6 0.6 5.5 3 3 1 4 4 4 4 Immunoglobulin V-set domain Ig_5 PF16681.3 204711.1_23523001_1 - 3.1e-09 37.0 1.0 0.017 15.4 0.0 4.0 3 2 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 204711.1_23523001_1 - 3.1e-07 30.2 0.6 0.015 15.2 0.2 4.0 3 1 0 3 3 3 2 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 204711.1_23523001_1 - 1.2e-05 25.2 0.1 0.057 13.4 0.0 3.2 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.3 204711.1_23523001_1 - 0.0005 20.2 0.5 2 8.7 0.0 3.9 3 2 1 4 4 4 1 T-cell surface glycoprotein CD3 delta chain V-set_CD47 PF08204.9 204711.1_23523001_1 - 0.0078 16.1 0.6 1.4 8.8 0.1 2.9 3 0 0 3 3 3 1 CD47 immunoglobulin-like domain LysM PF01476.18 001002104.1_16124001_1 - 0.00028 20.8 0.0 0.00051 20.0 0.0 1.4 1 0 0 1 1 1 1 LysM domain Dynamitin PF04912.12 201166.1_16125001_3 - 5e-122 407.8 15.2 5.9e-122 407.6 15.2 1.0 1 0 0 1 1 1 1 Dynamitin ZapB PF06005.10 201166.1_16125001_3 - 0.0032 17.7 19.0 0.059 13.7 0.9 4.2 3 2 0 3 3 3 2 Cell division protein ZapB PRD PF00874.18 201166.1_16125001_3 - 0.055 13.6 0.5 0.055 13.6 0.5 2.3 3 0 0 3 3 3 0 PRD domain TRPM_tetra PF16519.3 201166.1_16125001_3 - 0.32 11.0 4.2 1.8 8.6 0.1 3.3 3 1 0 3 3 3 0 Tetramerisation domain of TRPM Sec34 PF04136.13 201166.1_16125001_3 - 1.6 8.5 10.7 0.52 10.1 5.1 2.6 2 0 0 2 2 2 0 Sec34-like family EzrA PF06160.10 201166.1_16125001_3 - 1.8 6.5 10.5 0.4 8.7 5.8 2.1 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA Fib_alpha PF08702.8 201166.1_16125001_3 - 4.4 7.4 14.5 1.4 9.0 0.4 3.0 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family IncA PF04156.12 201166.1_16125001_3 - 7.8 6.1 20.4 2 8.0 8.9 3.6 2 1 1 3 3 3 0 IncA protein UQ_con PF00179.24 131351.2_16123001_3 - 2.8e-48 163.0 0.0 4e-48 162.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.4 131351.2_16123001_3 - 0.00029 20.4 0.0 0.00047 19.7 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B p450 PF00067.20 001001616.1_23526001_1 - 2.2e-152 507.9 0.0 2.6e-152 507.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 GARS_A PF01071.17 001001469.1_23528001_2 - 2.6e-90 301.3 0.0 4.7e-90 300.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Formyl_trans_N PF00551.17 001001469.1_23528001_2 - 9.4e-68 227.4 0.0 1.9e-67 226.4 0.0 1.5 1 0 0 1 1 1 1 Formyl transferase AIRS_C PF02769.20 001001469.1_23528001_2 - 5.3e-40 137.0 0.2 1.9e-39 135.2 0.0 2.1 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain GARS_N PF02844.13 001001469.1_23528001_2 - 5.4e-37 126.3 0.3 3.1e-35 120.7 0.1 3.2 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.14 001001469.1_23528001_2 - 2.1e-28 98.3 0.8 7.4e-28 96.5 0.2 2.3 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.22 001001469.1_23528001_2 - 3.1e-17 62.9 0.7 1.2e-16 61.0 0.7 2.1 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain ATPgrasp_Ter PF15632.4 001001469.1_23528001_2 - 2.5e-07 29.6 0.0 5.7e-07 28.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.12 001001469.1_23528001_2 - 0.00052 20.0 0.0 0.0011 18.9 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.20 001001469.1_23528001_2 - 0.00067 19.1 0.0 0.0024 17.3 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_4 PF13535.4 001001469.1_23528001_2 - 0.0025 17.3 0.0 0.0077 15.7 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.15 001001469.1_23528001_2 - 0.0056 16.1 0.1 0.019 14.3 0.1 1.9 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_2 PF08442.8 001001469.1_23528001_2 - 0.018 14.5 0.0 0.042 13.3 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain Dala_Dala_lig_C PF07478.11 001001469.1_23528001_2 - 0.019 14.3 0.0 0.036 13.5 0.0 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus Hydrolase_4 PF12146.6 001012871.1_23527001_1 - 2.1e-16 59.8 0.0 2.7e-13 49.6 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 001012871.1_23527001_1 - 4.1e-13 49.4 0.7 9.4e-12 45.0 0.9 2.1 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001012871.1_23527001_1 - 3.8e-08 34.1 0.1 3.8e-08 34.1 0.1 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.11 001012871.1_23527001_1 - 0.0024 17.6 0.0 0.0041 16.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.18 001012871.1_23527001_1 - 0.027 14.4 0.0 0.042 13.8 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain Peptidase_S15 PF02129.16 001012871.1_23527001_1 - 0.11 11.9 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) L27 PF02828.14 001031067.1_23528001_1 - 5.5e-22 77.1 0.2 1e-21 76.3 0.2 1.5 1 0 0 1 1 1 1 L27 domain PDZ PF00595.22 001031067.1_23528001_1 - 9.9e-20 70.6 0.6 1.5e-19 70.0 0.6 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001031067.1_23528001_1 - 0.055 13.6 0.0 0.094 12.9 0.0 1.2 1 0 0 1 1 1 0 PDZ domain MFS_1 PF07690.14 001030828.1_23529001_3 - 4.1e-15 55.4 24.9 4.1e-15 55.4 24.9 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily HS1_rep PF02218.13 205468.1_23525001_2 - 4.6e-131 426.8 78.3 7.9e-21 74.1 3.7 8.4 8 0 0 8 8 8 7 Repeat in HS1/Cortactin SH3_9 PF14604.4 205468.1_23525001_2 - 5.1e-17 61.3 0.2 1e-16 60.4 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 205468.1_23525001_2 - 3.3e-16 58.5 0.2 7.5e-16 57.3 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 205468.1_23525001_2 - 1.9e-09 36.9 0.0 4.5e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain TMEM210 PF15195.4 205468.1_23525001_2 - 4.6e-08 33.4 6.8 4.6 7.6 0.0 7.0 1 1 5 7 7 7 2 TMEM210 family Tho2 PF11262.6 205468.1_23525001_2 - 0.36 9.8 7.1 0.67 9.0 7.1 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Mnd1 PF03962.13 205468.1_23525001_2 - 1 9.0 10.3 2.7 7.7 10.3 1.6 1 0 0 1 1 1 0 Mnd1 family DUF3602 PF12223.6 205468.1_23525001_2 - 5.4 7.5 26.8 0.42 11.1 3.8 4.9 1 1 3 5 5 5 0 Protein of unknown function (DUF3602) Filament PF00038.19 205285.1_23525001_1 - 3.1e-104 348.8 55.9 4.4e-104 348.3 55.9 1.2 1 0 0 1 1 1 1 Intermediate filament protein LTD PF00932.17 205285.1_23525001_1 - 1.7e-18 66.8 0.4 3.8e-18 65.7 0.4 1.6 1 0 0 1 1 1 1 Lamin Tail Domain BRE1 PF08647.9 205285.1_23525001_1 - 0.0014 18.5 6.9 0.0014 18.5 6.9 4.5 2 1 3 5 5 4 1 BRE1 E3 ubiquitin ligase ADIP PF11559.6 205285.1_23525001_1 - 0.017 15.0 1.4 0.017 15.0 1.4 4.5 2 1 2 4 4 3 0 Afadin- and alpha -actinin-Binding DUF1326 PF07040.9 205285.1_23525001_1 - 0.084 12.7 0.3 0.3 11.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1326) FlaC_arch PF05377.9 205285.1_23525001_1 - 0.62 10.4 10.9 4.3 7.7 0.0 4.5 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) Reo_sigmaC PF04582.10 205285.1_23525001_1 - 0.91 8.7 7.0 2.4 7.3 0.7 2.6 2 1 0 2 2 2 0 Reovirus sigma C capsid protein DUF1844 PF08899.9 205285.1_23525001_1 - 1.4 9.1 9.2 0.62 10.3 0.7 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1844) Atg14 PF10186.7 205285.1_23525001_1 - 1.5 7.7 42.3 0.21 10.5 6.8 3.2 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 M PF02370.14 205285.1_23525001_1 - 1.9 9.2 9.0 10 7.0 1.5 5.0 2 0 0 2 2 2 0 M protein repeat DUF948 PF06103.9 205285.1_23525001_1 - 3.5 7.8 5.2 14 5.9 0.1 3.6 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) FPP PF05911.9 205285.1_23525001_1 - 4.7 5.2 51.2 0.068 11.3 19.1 3.2 1 1 2 3 3 3 0 Filament-like plant protein, long coiled-coil Spc7 PF08317.9 205285.1_23525001_1 - 7.6 5.2 50.8 1.3 7.7 7.8 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein IncA PF04156.12 205285.1_23525001_1 - 9.7 5.8 61.7 3.5 7.2 18.8 3.9 1 1 2 3 3 2 0 IncA protein LysM PF01476.18 001031414.1_23525001_1 - 0.00022 21.1 0.1 0.00044 20.2 0.1 1.5 1 0 0 1 1 1 1 LysM domain UMPH-1 PF05822.10 199560.1_16124001_1 - 1.6e-119 397.8 0.8 2.1e-119 397.4 0.8 1.1 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD PF12710.5 199560.1_16124001_1 - 0.00012 22.4 0.1 0.00021 21.6 0.1 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HLH PF00010.24 205375.4_23529001_3 - 4.1e-10 39.4 2.4 8.8e-10 38.3 1.3 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.12 205375.4_23529001_3 - 7.5 4.6 9.6 8.5 4.4 8.7 1.4 2 0 0 2 2 2 0 CDC45-like protein SAC3_GANP PF03399.14 001089519.1_16129001_2 - 5.1e-25 88.3 0.4 6.9e-24 84.6 0.4 2.1 1 1 0 1 1 1 1 SAC3/GANP family Rpr2 PF04032.14 001089519.1_16129001_2 - 1.1 9.5 5.6 2.8 8.2 5.6 1.6 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain RasGEF PF00617.17 001100146.1_16126001_2 - 2e-49 167.9 1.7 5.4e-49 166.6 1.0 1.8 1 1 1 2 2 2 1 RasGEF domain PH PF00169.27 001100146.1_16126001_2 - 3.4e-13 49.9 0.0 6.4e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 PH domain Pkinase PF00069.23 001040308.1_16125001_2 - 4.5e-64 216.2 0.0 5.8e-64 215.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001040308.1_16125001_2 - 1.5e-29 103.0 0.0 2.2e-29 102.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase BOP1NT PF08145.10 001077735.1_16126001_2 - 1.6e-111 372.3 5.2 2.9e-111 371.4 5.2 1.4 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.30 001077735.1_16126001_2 - 2e-28 97.9 12.6 5.8e-10 39.5 0.6 7.5 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001077735.1_16126001_2 - 1.1e-06 28.7 0.2 0.02 15.1 0.1 4.0 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain CDC45 PF02724.12 001077735.1_16126001_2 - 5.3 5.1 25.2 8.1 4.5 25.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Paf1 PF03985.11 001024453.1_16125001_1 - 1.4e-147 492.0 27.5 1.4e-147 492.0 27.5 2.1 1 1 1 2 2 2 1 Paf1 BUD22 PF09073.8 001024453.1_16125001_1 - 7.4 5.7 48.3 15 4.6 48.3 1.5 1 0 0 1 1 1 0 BUD22 Connexin PF00029.17 001040644.1_23524001_1 - 4.5e-101 337.2 0.0 5.7e-101 336.9 0.0 1.1 1 0 0 1 1 1 1 Connexin Connexin40_C PF16791.3 001040644.1_23524001_1 - 1.4e-10 42.2 0.8 1e-06 29.8 0.1 2.5 2 0 0 2 2 2 2 Connexin 40 C-terminal domain Ski_Sno PF02437.15 001039318.1_23525001_1 - 3e-46 155.5 0.3 6e-46 154.6 0.3 1.5 1 0 0 1 1 1 1 SKI/SNO/DAC family c-SKI_SMAD_bind PF08782.8 001039318.1_23525001_1 - 3.3e-40 136.1 1.1 1.2e-39 134.3 1.1 2.0 1 0 0 1 1 1 1 c-SKI Smad4 binding domain AAA_13 PF13166.4 001039318.1_23525001_1 - 0.17 10.4 14.3 0.28 9.7 14.3 1.3 1 0 0 1 1 1 0 AAA domain Linker_histone PF00538.17 001081703.1_23522001_1 - 5.1e-22 77.9 0.7 5.1e-22 77.9 0.7 2.2 2 1 0 2 2 2 1 linker histone H1 and H5 family dsrm PF00035.24 001089361.1_16124001_3 - 3.9e-27 94.6 0.0 9.6e-12 45.3 0.0 3.5 3 0 0 3 3 3 3 Double-stranded RNA binding motif Staufen_C PF16482.3 001089361.1_16124001_3 - 3e-12 46.5 0.1 2.7e-09 37.1 0.0 2.4 2 0 0 2 2 2 2 Staufen C-terminal domain DND1_DSRM PF14709.5 001089361.1_16124001_3 - 2e-10 40.7 2.6 3.9e-06 26.9 0.0 4.0 3 2 0 3 3 3 2 double strand RNA binding domain from DEAD END PROTEIN 1 Collagen PF01391.16 001100911.1_23528001_1 - 1.7e-92 303.0 357.7 2.2e-09 36.8 32.7 12.3 3 3 9 12 12 12 12 Collagen triple helix repeat (20 copies) Laminin_G_2 PF02210.22 001100911.1_23528001_1 - 0.064 13.7 0.0 0.11 13.0 0.0 1.2 1 0 0 1 1 1 0 Laminin G domain DUF3456 PF11938.6 001039497.2_16123001_3 - 1.4e-40 139.2 0.0 2.2e-40 138.6 0.0 1.3 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP EF-hand_1 PF00036.30 001044632.1_23522001_2 - 2.9e-10 38.8 4.2 0.02 14.3 0.1 4.9 5 1 0 5 5 5 2 EF hand EF-hand_6 PF13405.4 001044632.1_23522001_2 - 5.9e-10 38.2 0.6 0.0013 18.4 0.2 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.4 001044632.1_23522001_2 - 1.2e-09 38.3 0.0 0.00051 20.3 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 001044632.1_23522001_2 - 6.2e-05 22.5 1.8 0.21 11.3 0.1 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.4 001044632.1_23522001_2 - 0.0012 18.9 0.0 2 8.6 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain Cas9_REC PF16592.3 001044632.1_23522001_2 - 0.039 12.6 0.1 0.05 12.2 0.1 1.1 1 0 0 1 1 1 0 REC lobe of CRISPR-associated endonuclease Cas9 SapB_1 PF05184.13 001044632.1_23522001_2 - 0.11 12.4 0.1 16 5.5 0.0 2.5 2 0 0 2 2 2 0 Saposin-like type B, region 1 LMWPc PF01451.19 001039291.1_23522001_3 - 4.8e-50 169.5 0.1 5.8e-50 169.2 0.1 1.1 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Filament PF00038.19 001001311.2_23524001_2 - 4.6e-120 400.8 26.5 5.6e-120 400.5 26.5 1.1 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001001311.2_23524001_2 - 0.001 19.1 42.4 0.002 18.2 42.4 1.3 1 0 0 1 1 1 1 Keratin type II head DUF4407 PF14362.4 001001311.2_23524001_2 - 0.0058 15.9 17.1 0.16 11.1 8.1 2.8 1 1 0 2 2 2 2 Domain of unknown function (DUF4407) SlyX PF04102.10 001001311.2_23524001_2 - 0.0094 16.4 21.5 4.7 7.8 2.9 5.6 4 1 1 5 5 5 1 SlyX Bacillus_HBL PF05791.9 001001311.2_23524001_2 - 0.23 11.1 8.0 0.069 12.8 2.6 2.7 1 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Atg14 PF10186.7 001001311.2_23524001_2 - 0.27 10.1 19.4 1 8.2 6.9 3.0 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.10 001001311.2_23524001_2 - 0.46 10.4 12.8 10 6.0 1.1 4.2 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) DUF3373 PF11853.6 001001311.2_23524001_2 - 0.53 8.8 8.1 47 2.4 8.1 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) DUF342 PF03961.11 001001311.2_23524001_2 - 0.8 8.1 14.5 1.1 7.6 2.7 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF342) Reo_sigmaC PF04582.10 001001311.2_23524001_2 - 0.89 8.8 6.9 1.4 8.1 2.5 2.3 1 1 0 2 2 2 0 Reovirus sigma C capsid protein TPR_MLP1_2 PF07926.10 001001311.2_23524001_2 - 1.4 8.9 28.7 0.39 10.6 2.0 3.6 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.7 001001311.2_23524001_2 - 1.7 8.7 25.8 0.43 10.7 1.6 3.8 3 1 1 4 4 4 0 JNK_SAPK-associated protein-1 Prefoldin_2 PF01920.18 001001311.2_23524001_2 - 1.8 8.4 17.7 8.7 6.2 0.5 4.1 3 1 0 3 3 3 0 Prefoldin subunit DUF4618 PF15397.4 001001311.2_23524001_2 - 2 7.7 16.3 0.061 12.6 6.9 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4618) Cob_adeno_trans PF01923.16 001001311.2_23524001_2 - 2.1 8.4 8.0 2.7 8.0 2.5 2.9 2 1 0 2 2 2 0 Cobalamin adenosyltransferase Golgin_A5 PF09787.7 001001311.2_23524001_2 - 3.3 7.0 23.6 2.8 7.2 2.7 2.5 1 1 0 2 2 2 0 Golgin subfamily A member 5 DUF4446 PF14584.4 001001311.2_23524001_2 - 3.7 7.4 10.2 4.8 7.0 0.1 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) Baculo_PEP_C PF04513.10 001001311.2_23524001_2 - 5.5 6.9 15.9 5.5 6.9 4.6 3.9 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus TolA_bind_tri PF16331.3 001001311.2_23524001_2 - 5.7 7.0 26.6 0.46 10.5 3.1 4.8 3 2 2 5 5 5 0 TolA binding protein trimerisation Lzipper-MIP1 PF14389.4 001001311.2_23524001_2 - 6.1 7.0 17.7 0.17 12.0 1.6 4.3 4 1 0 4 4 3 0 Leucine-zipper of ternary complex factor MIP1 TBPIP PF07106.11 001001311.2_23524001_2 - 6.1 6.5 19.1 0.81 9.3 5.4 3.7 2 1 2 5 5 5 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Lectin_N PF03954.12 001001311.2_23524001_2 - 7.9 6.1 9.3 8.7 6.0 0.1 3.1 2 1 0 3 3 2 0 Hepatic lectin, N-terminal domain RasGAP_C PF03836.13 001001311.2_23524001_2 - 9 6.3 16.9 1.2 9.2 1.2 3.3 2 1 2 4 4 3 0 RasGAP C-terminus FlxA PF14282.4 001001311.2_23524001_2 - 9.4 6.2 18.8 4.7 7.1 6.7 3.4 3 1 1 4 4 3 0 FlxA-like protein Piwi PF02171.15 001039276.1_23528001_1 - 7.6e-104 347.0 0.0 1.2e-103 346.4 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.3 001039276.1_23528001_1 - 7.2e-33 112.6 0.4 2e-32 111.2 0.1 2.0 2 0 0 2 2 2 1 Mid domain of argonaute PAZ PF02170.20 001039276.1_23528001_1 - 1.2e-28 99.5 2.0 1.2e-28 99.5 2.0 1.6 2 0 0 2 2 2 1 PAZ domain ArgoN PF16486.3 001039276.1_23528001_1 - 2e-28 99.5 0.0 5.3e-28 98.2 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.8 001039276.1_23528001_1 - 6.5e-23 80.0 0.1 1.4e-22 78.9 0.1 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.3 001039276.1_23528001_1 - 3.1e-15 56.1 0.0 6.5e-15 55.1 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 2 domain 4F5 PF04419.12 001097531.1_23526001_3 - 2.6e-09 37.7 17.3 4.6e-09 36.9 17.3 1.4 1 0 0 1 1 1 1 4F5 protein family zf-met PF12874.5 001097531.1_23526001_3 - 0.0018 18.5 0.4 0.0018 18.5 0.4 2.0 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001097531.1_23526001_3 - 0.043 14.0 0.1 0.14 12.4 0.1 1.9 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.4 001097531.1_23526001_3 - 8.2 7.4 12.7 0.56 11.0 1.3 3.3 2 0 0 2 2 2 0 C2H2-type zinc finger Sprouty PF05210.11 001097524.1_23522001_1 - 3.3e-32 111.0 33.5 5.7e-32 110.2 33.5 1.4 1 0 0 1 1 1 1 Sprouty protein (Spry) Kelch_1 PF01344.23 001003727.2_16129001_1 - 5.4e-40 134.6 14.0 3.8e-09 35.8 0.0 6.8 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.4 001003727.2_16129001_1 - 7.8e-33 111.5 4.8 5.7e-07 29.5 0.4 6.2 3 1 3 6 6 6 5 Kelch motif BACK PF07707.13 001003727.2_16129001_1 - 1.4e-26 92.5 0.4 2.4e-26 91.7 0.4 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.4 001003727.2_16129001_1 - 3.4e-20 71.7 2.0 3.6e-05 23.8 0.0 5.0 5 0 0 5 5 5 4 Galactose oxidase, central domain BTB PF00651.29 001003727.2_16129001_1 - 1.9e-18 66.6 0.4 1.9e-18 66.6 0.4 2.7 2 1 2 4 4 4 1 BTB/POZ domain Kelch_2 PF07646.13 001003727.2_16129001_1 - 2e-18 65.4 5.5 4.4e-08 32.7 0.2 6.6 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.4 001003727.2_16129001_1 - 2e-13 49.9 1.1 0.0011 18.8 0.0 5.6 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.4 001003727.2_16129001_1 - 3.6e-11 42.7 6.0 0.11 12.4 0.1 5.5 5 0 0 5 5 5 4 Kelch motif DnaJ PF00226.29 001039330.1_23529001_2 - 1.1e-24 86.1 0.2 2.1e-24 85.3 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.18 001039330.1_23529001_2 - 8.6e-09 35.1 0.0 1.2e-06 28.3 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_3 PF13192.4 001039330.1_23529001_2 - 0.046 13.6 0.0 0.082 12.8 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin domain RRM_1 PF00076.20 001045258.1_16125001_2 - 1.5e-31 107.9 0.1 1.2e-14 53.7 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.9 001045258.1_16125001_2 - 2e-26 91.7 1.5 6.9e-26 90.0 0.8 2.2 2 0 0 2 2 2 1 NOPS (NUC059) domain RRM_7 PF16367.3 001045258.1_16125001_2 - 0.073 13.1 0.0 0.45 10.5 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif Aldedh PF00171.20 001045258.1_16125001_2 - 4 5.7 5.0 5.8 5.2 5.0 1.1 1 0 0 1 1 1 0 Aldehyde dehydrogenase family GGACT PF06094.10 001089560.1_16124001_3 - 2.2e-19 70.1 0.0 3.1e-19 69.6 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like Vps51 PF08700.9 001042735.1_16125001_1 - 4e-25 87.6 1.7 6e-25 87.0 0.3 2.1 2 0 0 2 2 2 1 Vps51/Vps67 Sec5 PF15469.4 001042735.1_16125001_1 - 9.4e-18 64.6 0.3 1.8e-17 63.6 0.3 1.5 1 0 0 1 1 1 1 Exocyst complex component Sec5 Dor1 PF04124.10 001042735.1_16125001_1 - 1.6e-12 46.7 3.8 3.7e-12 45.4 3.8 1.6 1 0 0 1 1 1 1 Dor1-like family Vps54_N PF10475.7 001042735.1_16125001_1 - 2.1e-07 30.4 2.1 4.5e-07 29.3 2.1 1.5 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex COG2 PF06148.9 001042735.1_16125001_1 - 1.9e-06 27.9 3.5 1.9e-06 27.8 0.3 2.7 3 1 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 COG5 PF10392.7 001042735.1_16125001_1 - 0.0011 19.0 0.6 0.0032 17.5 0.1 2.1 2 0 0 2 2 2 1 Golgi transport complex subunit 5 Vps53_N PF04100.10 001042735.1_16125001_1 - 0.0037 16.1 1.7 0.0064 15.4 1.7 1.3 1 0 0 1 1 1 1 Vps53-like, N-terminal YxiJ PF14176.4 001042735.1_16125001_1 - 0.013 15.9 0.1 0.031 14.6 0.1 1.7 1 0 0 1 1 1 0 YxiJ-like protein Sec8_exocyst PF04048.12 001042735.1_16125001_1 - 0.065 13.0 1.3 0.15 11.9 0.4 2.1 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain IFT57 PF10498.7 001042735.1_16125001_1 - 0.077 11.8 1.4 0.13 11.0 0.6 1.7 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 DUF2115 PF09888.7 001042735.1_16125001_1 - 0.081 13.3 0.9 0.24 11.7 0.9 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) DUF1736 PF08409.9 001042735.1_16125001_1 - 0.11 12.4 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1736) Apolipoprotein PF01442.16 001042735.1_16125001_1 - 0.31 10.8 5.1 11 5.7 0.0 2.9 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF4164 PF13747.4 001042735.1_16125001_1 - 1.3 9.3 3.3 20 5.4 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) Sigma54_CBD PF04963.11 001042735.1_16125001_1 - 1.5 8.5 3.8 2.1 8.0 0.5 2.5 2 1 0 2 2 2 0 Sigma-54 factor, core binding domain CENP-F_leu_zip PF10473.7 001042735.1_16125001_1 - 3.1 7.7 5.6 0.79 9.6 1.5 2.0 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BAR PF03114.16 001080896.2_23524001_3 - 7.8e-35 120.5 11.2 1.1e-34 120.0 11.2 1.1 1 0 0 1 1 1 1 BAR domain Clusterin PF01093.15 001080896.2_23524001_3 - 0.061 12.2 2.7 0.1 11.5 2.7 1.3 1 0 0 1 1 1 0 Clusterin FliS PF02561.12 001080896.2_23524001_3 - 0.13 12.4 1.8 0.35 11.0 0.2 2.4 2 1 1 3 3 3 0 Flagellar protein FliS BLOC1_2 PF10046.7 001080896.2_23524001_3 - 7.4 6.8 10.3 3.8 7.8 2.2 2.7 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Collagen PF01391.16 001039599.1_23526001_2 - 2.2e-23 81.6 98.7 2.3e-09 36.7 32.5 3.2 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) Lectin_C PF00059.19 001039599.1_23526001_2 - 5.5e-21 75.2 1.4 2.1e-20 73.4 1.4 2.1 1 0 0 1 1 1 1 Lectin C-type domain Filament PF00038.19 001039599.1_23526001_2 - 0.0011 18.5 29.8 0.0011 18.5 29.8 2.1 1 1 1 2 2 2 1 Intermediate filament protein Reo_sigmaC PF04582.10 001039599.1_23526001_2 - 0.0044 16.3 35.9 0.085 12.1 6.3 4.0 1 1 3 4 4 4 3 Reovirus sigma C capsid protein Spc7 PF08317.9 001039599.1_23526001_2 - 0.0064 15.3 34.2 0.04 12.7 15.0 2.8 1 1 0 2 2 2 2 Spc7 kinetochore protein IncA PF04156.12 001039599.1_23526001_2 - 0.019 14.6 29.5 0.25 11.0 7.4 3.7 2 1 1 3 3 3 0 IncA protein Fib_alpha PF08702.8 001039599.1_23526001_2 - 0.022 14.8 37.9 0.016 15.3 7.7 4.1 1 1 2 4 4 4 0 Fibrinogen alpha/beta chain family DUF948 PF06103.9 001039599.1_23526001_2 - 1.4 9.1 25.8 1.9 8.7 0.9 4.8 3 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.10 001039599.1_23526001_2 - 2.3 8.1 30.1 2.3 8.1 7.8 4.3 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) DUF4795 PF16043.3 001039599.1_23526001_2 - 5.2 6.5 35.9 0.1 12.1 3.7 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) DUF4208 PF13907.4 001039599.1_23526001_2 - 5.4 7.4 8.7 1.8 8.9 1.6 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4208) Jnk-SapK_ap_N PF09744.7 001039599.1_23526001_2 - 5.7 7.0 27.8 0.55 10.3 3.8 3.6 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 KapB PF08810.8 001039599.1_23526001_2 - 6.5 6.9 7.6 2.8 8.1 2.6 2.7 2 2 0 2 2 2 0 Kinase associated protein B NPV_P10 PF05531.10 001039599.1_23526001_2 - 7.5 7.0 27.3 0.78 10.1 4.7 5.3 2 2 3 5 5 5 0 Nucleopolyhedrovirus P10 protein Kinesin PF00225.21 001113591.1_16125001_3 - 1.5e-99 333.0 0.0 2.5e-99 332.2 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 001113591.1_16125001_3 - 1.8e-26 92.7 0.0 4.1e-26 91.6 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding HHH_3 PF12836.5 001113591.1_16125001_3 - 4.3e-10 39.6 0.1 2e-09 37.4 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_6 PF14579.4 001113591.1_16125001_3 - 0.00083 19.4 0.0 0.0022 18.1 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH PF00633.21 001113591.1_16125001_3 - 0.072 12.8 0.0 12 5.8 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix motif DivIC PF04977.13 001113591.1_16125001_3 - 3.8 7.2 6.4 8.7 6.1 6.4 1.6 1 0 0 1 1 1 0 Septum formation initiator BTB_2 PF02214.20 001039269.1_23528001_1 - 2.4e-18 66.1 0.0 5.5e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.3 001039269.1_23528001_1 - 0.059 13.4 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain PUA PF01472.18 001105675.1_23525001_1 - 9.2e-20 70.3 0.1 1.4e-19 69.6 0.1 1.3 1 0 0 1 1 1 1 PUA domain Pkinase_Tyr PF07714.15 001109787.1_23524001_1 - 3.3e-93 311.6 0.0 4.1e-93 311.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001109787.1_23524001_1 - 8.1e-45 153.1 0.0 1.1e-44 152.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001109787.1_23524001_1 - 4.2e-27 93.9 0.2 9e-27 92.8 0.2 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001109787.1_23524001_1 - 2.6e-19 68.4 0.3 9e-19 66.7 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 001109787.1_23524001_1 - 1.9e-13 49.9 0.0 4.6e-13 48.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001109787.1_23524001_1 - 5.3e-11 41.9 0.0 1.4e-10 40.5 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain APH PF01636.21 001109787.1_23524001_1 - 0.057 13.2 0.0 0.55 10.0 0.0 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family FrhB_FdhB_C PF04432.11 001109787.1_23524001_1 - 0.085 12.6 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus Exo_endo_phos PF03372.21 001077615.1_16125001_2 - 1.9e-08 34.4 0.0 2.9e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Cyclin PF08613.9 001039307.1_23525001_1 - 2.2e-06 28.0 0.0 3.3e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.21 001039307.1_23525001_1 - 0.00057 19.5 0.1 0.0011 18.6 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain I-set PF07679.14 001044659.1_23527001_1 - 6.1e-91 298.5 0.0 4.1e-16 58.7 0.0 7.4 7 0 0 7 7 7 7 Immunoglobulin I-set domain Ig_3 PF13927.4 001044659.1_23527001_1 - 1.2e-60 201.9 0.0 1.2e-10 41.7 0.0 7.7 8 0 0 8 8 7 7 Immunoglobulin domain fn3 PF00041.19 001044659.1_23527001_1 - 3.3e-48 161.8 1.0 3.4e-16 59.2 0.1 4.3 4 0 0 4 4 4 3 Fibronectin type III domain Ig_2 PF13895.4 001044659.1_23527001_1 - 9.4e-34 115.5 0.0 8.1e-08 32.4 0.0 7.4 6 1 1 7 7 7 7 Immunoglobulin domain ig PF00047.23 001044659.1_23527001_1 - 2.9e-31 107.3 0.0 2e-05 24.6 0.0 7.5 7 0 0 7 7 7 5 Immunoglobulin domain V-set PF07686.15 001044659.1_23527001_1 - 4e-18 65.4 3.5 0.0032 17.5 0.1 10.7 7 5 0 7 7 7 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 001044659.1_23527001_1 - 8.1e-11 41.7 0.1 0.15 12.1 0.0 5.8 5 1 1 6 6 6 3 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 001044659.1_23527001_1 - 1.2e-06 28.7 0.8 2.9 8.3 0.0 6.6 5 1 2 7 7 7 1 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 001044659.1_23527001_1 - 2.1e-05 24.3 0.3 0.23 11.4 0.0 4.6 6 0 0 6 6 5 1 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.6 001044659.1_23527001_1 - 0.0012 18.9 0.0 0.97 9.5 0.0 3.8 3 0 0 3 3 3 1 Natural killer cell receptor 2B4 DUF11 PF01345.16 001044659.1_23527001_1 - 0.068 13.4 0.0 0.59 10.3 0.0 2.6 3 0 0 3 3 2 0 Domain of unknown function DUF11 DUF3016 PF11454.6 001044659.1_23527001_1 - 0.099 12.3 0.1 0.71 9.5 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3016) Abhydrolase_1 PF00561.18 001004290.2_16123001_3 - 5.3e-21 75.3 0.0 8e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001004290.2_16123001_3 - 2.6e-19 70.6 0.0 3.4e-19 70.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 001004290.2_16123001_3 - 7.6e-13 48.1 0.2 1.4e-12 47.3 0.2 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.18 001004290.2_16123001_3 - 3.1e-10 40.5 0.0 4.6e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.11 001004290.2_16123001_3 - 1e-07 31.8 1.3 0.00015 21.4 0.5 2.2 1 1 1 2 2 2 2 PGAP1-like protein DUF915 PF06028.9 001004290.2_16123001_3 - 0.00013 21.3 0.0 0.17 11.0 0.0 2.5 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) Ndr PF03096.12 001004290.2_16123001_3 - 0.00023 19.8 0.0 0.00037 19.2 0.0 1.4 1 1 0 1 1 1 1 Ndr family Esterase PF00756.18 001004290.2_16123001_3 - 0.00085 18.9 0.0 0.0014 18.2 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Lipase_3 PF01764.23 001004290.2_16123001_3 - 0.029 14.1 0.3 0.059 13.1 0.2 1.5 1 1 0 1 1 1 0 Lipase (class 3) Abhydrolase_3 PF07859.11 001004290.2_16123001_3 - 0.032 13.9 0.0 0.045 13.4 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2974 PF11187.6 001004290.2_16123001_3 - 0.059 12.8 0.0 0.088 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) PAF-AH_p_II PF03403.11 001004290.2_16123001_3 - 0.06 11.7 0.5 2.1 6.7 0.1 2.1 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II CRAL_TRIO_2 PF13716.4 182881.2_16127001_3 - 1e-05 25.5 0.0 2.1e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Spectrin PF00435.19 182881.2_16127001_3 - 0.00026 21.3 0.4 0.00026 21.3 0.4 4.2 5 0 0 5 5 5 3 Spectrin repeat RasGAP_C PF03836.13 182881.2_16127001_3 - 0.25 11.3 4.1 0.43 10.6 0.7 2.7 2 0 0 2 2 2 0 RasGAP C-terminus Isochorismatase PF00857.18 001079953.2_16122001_3 - 1.3e-26 93.7 0.5 1.8e-26 93.2 0.0 1.5 2 0 0 2 2 2 1 Isochorismatase family YojJ PF10372.7 001079953.2_16122001_3 - 0.058 13.4 0.0 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus HSP90 PF00183.16 001109785.1_23525001_1 - 1.4e-243 809.3 33.8 1.8e-243 809.0 33.8 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.24 001109785.1_23525001_1 - 1.5e-13 51.1 0.1 4.1e-13 49.7 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.4 001109785.1_23525001_1 - 1.8e-11 43.9 0.2 5.7e-11 42.3 0.2 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.7 001109785.1_23525001_1 - 0.098 12.6 1.3 0.32 10.9 0.2 2.2 2 0 0 2 2 2 0 Tumour suppressor protein DUF1198 PF06711.9 001109785.1_23525001_1 - 0.17 11.9 0.7 0.5 10.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1198) CDC45 PF02724.12 001109785.1_23525001_1 - 1.2 7.2 12.7 2.4 6.2 12.7 1.4 1 0 0 1 1 1 0 CDC45-like protein LRR_6 PF13516.4 001080042.1_16125001_2 - 3.5e-22 76.4 2.7 0.087 12.8 0.1 10.7 11 0 0 11 11 11 6 Leucine Rich repeat F-box-like PF12937.5 001080042.1_16125001_2 - 1.6e-14 53.3 4.4 1.6e-14 53.3 4.4 2.0 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.5 001080042.1_16125001_2 - 1.3e-12 47.5 0.0 0.055 13.8 0.0 6.0 3 2 4 7 7 7 5 Leucine Rich repeats (2 copies) F-box PF00646.31 001080042.1_16125001_2 - 9.2e-11 41.2 6.1 2.4e-10 39.9 1.2 3.0 2 0 0 2 2 2 1 F-box domain LRR_1 PF00560.31 001080042.1_16125001_2 - 5.9e-08 32.0 9.7 4.3 8.1 0.0 9.3 10 0 0 10 10 10 2 Leucine Rich Repeat MSA-2c PF12238.6 001080042.1_16125001_2 - 6.4 6.6 9.8 9.4 6.0 9.8 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c SAICAR_synt PF01259.16 205524.2_23525001_1 - 5.3e-54 183.3 0.1 7.3e-54 182.9 0.1 1.1 1 0 0 1 1 1 1 SAICAR synthetase AIRC PF00731.18 205524.2_23525001_1 - 6.7e-39 132.7 0.0 1.3e-38 131.8 0.0 1.4 1 0 0 1 1 1 1 AIR carboxylase XPG_I PF00867.16 001017611.2_16123001_3 - 4.1e-28 97.4 0.0 8.1e-28 96.5 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.15 001017611.2_16123001_3 - 2e-13 50.5 0.0 5.9e-13 49.0 0.0 1.8 2 0 0 2 2 2 1 XPG N-terminal domain 5_3_exonuc PF01367.18 001017611.2_16123001_3 - 0.0022 18.4 0.2 0.0081 16.6 0.0 2.0 2 1 1 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold XPG_I_2 PF12813.5 001017611.2_16123001_3 - 0.13 11.6 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 XPG domain containing Peptidase_M2 PF01401.16 001167732.1_23529001_1 - 0 1788.1 14.7 9.4e-273 905.9 3.3 2.0 2 0 0 2 2 2 2 Angiotensin-converting enzyme Ku_PK_bind PF08785.9 001167732.1_23529001_1 - 0.11 12.5 0.1 2.4 8.2 0.1 2.5 2 0 0 2 2 2 0 Ku C terminal domain like DDR PF08841.8 001167732.1_23529001_1 - 0.19 10.6 0.2 8.5 5.1 0.0 2.1 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Zip PF02535.20 001130777.1_16122001_2 - 2.3e-41 142.0 6.6 2.6e-41 141.8 6.6 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Neur_chan_memb PF02932.14 001167703.1_23524001_2 - 6.2e-54 183.4 0.0 8e-54 183.1 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 001167703.1_23524001_2 - 4.7e-51 173.2 0.0 6.7e-51 172.7 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain MMR_HSR1 PF01926.21 001128747.1_16124001_3 - 2.1e-21 76.0 0.2 3.4e-21 75.3 0.2 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001128747.1_16124001_3 - 4.7e-11 42.3 0.5 7.5e-11 41.7 0.5 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.21 001128747.1_16124001_3 - 2.5e-09 37.3 2.1 0.00011 22.2 0.2 2.4 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.25 001128747.1_16124001_3 - 2.9e-08 33.4 0.5 0.0007 19.1 0.2 2.9 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain KH_2 PF07650.15 001128747.1_16124001_3 - 1.1e-07 31.5 0.3 2.2e-07 30.5 0.3 1.6 1 0 0 1 1 1 1 KH domain AIG1 PF04548.14 001128747.1_16124001_3 - 1.4e-07 30.9 0.7 5.1e-07 29.1 0.5 1.9 1 1 1 2 2 2 1 AIG1 family ATP_bind_1 PF03029.15 001128747.1_16124001_3 - 8e-07 28.9 0.1 1.1e-05 25.2 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein DUF258 PF03193.14 001128747.1_16124001_3 - 9.2e-07 28.8 3.3 0.00022 21.0 0.2 2.6 3 0 0 3 3 3 2 Protein of unknown function, DUF258 G-alpha PF00503.18 001128747.1_16124001_3 - 0.00024 20.3 0.2 0.14 11.2 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Arf PF00025.19 001128747.1_16124001_3 - 0.00025 20.4 0.7 0.002 17.5 0.7 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 001128747.1_16124001_3 - 0.0052 16.9 0.2 0.068 13.3 0.2 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001128747.1_16124001_3 - 0.0087 15.5 0.1 0.035 13.6 0.1 1.8 1 1 0 1 1 1 1 Ras family AAA_28 PF13521.4 001128747.1_16124001_3 - 0.021 15.0 0.1 0.5 10.5 0.1 2.2 1 1 1 2 2 2 0 AAA domain SRPRB PF09439.8 001128747.1_16124001_3 - 0.026 13.8 0.3 0.056 12.7 0.3 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.7 001128747.1_16124001_3 - 0.066 12.8 0.1 2.2 7.9 0.0 3.0 3 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation GBP PF02263.17 001128747.1_16124001_3 - 0.068 12.3 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain Myc_N PF01056.16 001126109.1_16124001_1 - 2.7e-13 50.4 21.6 6.1e-10 39.3 2.7 3.1 1 1 2 3 3 3 2 Myc amino-terminal region HLH PF00010.24 001126109.1_16124001_1 - 1.4e-12 47.2 4.4 1.4e-12 47.2 4.4 2.6 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain Myc-LZ PF02344.13 001126109.1_16124001_1 - 5.2e-05 23.1 12.9 5.2e-05 23.1 12.9 2.0 2 0 0 2 2 2 1 Myc leucine zipper domain PRIMA1 PF16101.3 001126109.1_16124001_1 - 0.79 9.6 4.6 3.7 7.5 1.4 2.3 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 OAD_gamma PF04277.11 001126109.1_16124001_1 - 0.92 10.0 4.2 2.4 8.6 4.2 1.8 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF4061 PF13270.4 001126109.1_16124001_1 - 3.5 7.9 8.3 0.68 10.2 0.1 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4061) Fibrinogen_C PF00147.16 001167683.1_23524001_3 - 2.3e-104 347.9 14.6 3.1e-104 347.5 14.6 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fib_alpha PF08702.8 001167683.1_23524001_3 - 1.1e-40 139.0 3.9 1.5e-40 138.5 3.9 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family DUF1465 PF07323.10 001167683.1_23524001_3 - 0.12 12.0 1.0 2.6 7.7 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) DUF5082 PF16888.3 001167683.1_23524001_3 - 0.3 11.3 5.8 0.48 10.6 3.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) ERp29_N PF07912.11 001276324.1_23524001_3 - 3.3e-51 172.6 0.2 4.9e-51 172.0 0.2 1.3 1 0 0 1 1 1 1 ERp29, N-terminal domain ERp29 PF07749.10 001276324.1_23524001_3 - 1.1e-23 83.7 6.5 1.7e-23 83.2 6.5 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain PRTase_1 PF11202.6 001276324.1_23524001_3 - 0.077 12.1 1.4 0.12 11.5 1.4 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase (PRTase) Laminin_G_2 PF02210.22 001271923.1_23529001_1 - 7.4e-149 488.6 10.1 3.4e-28 98.6 0.0 6.3 6 0 0 6 6 6 6 Laminin G domain Laminin_G_1 PF00054.21 001271923.1_23529001_1 - 1.9e-106 351.5 5.3 5.2e-25 88.0 0.0 7.7 7 1 0 7 7 7 6 Laminin G domain Laminin_G_3 PF13385.4 001271923.1_23529001_1 - 1.9e-22 79.9 4.5 5.2e-05 23.3 0.1 6.5 6 0 0 6 6 6 6 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 001271923.1_23529001_1 - 4.8e-14 52.2 35.6 1.2e-06 28.6 7.6 3.6 3 0 0 3 3 3 3 EGF-like domain Syndecan PF01034.18 001271923.1_23529001_1 - 2.6e-07 30.3 0.0 5.4e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Syndecan domain hEGF PF12661.5 001271923.1_23529001_1 - 1e-05 25.9 24.9 0.069 13.7 3.4 4.2 3 0 0 3 3 3 3 Human growth factor-like EGF DUF1080 PF06439.9 001271923.1_23529001_1 - 9e-05 22.5 2.6 1.9 8.4 0.0 4.2 4 0 0 4 4 4 2 Domain of Unknown Function (DUF1080) CD34_antigen PF06365.10 001271923.1_23529001_1 - 0.043 13.3 0.1 0.076 12.5 0.1 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF202 PF02656.13 001271923.1_23529001_1 - 0.09 13.1 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Laminin_G_2 PF02210.22 001271924.1_23526001_1 - 7.6e-23 81.3 0.9 1.1e-22 80.8 0.1 1.7 2 0 0 2 2 2 1 Laminin G domain Laminin_G_1 PF00054.21 001271924.1_23526001_1 - 3.5e-10 40.1 0.4 1.7e-09 37.9 0.0 2.3 2 0 0 2 2 2 1 Laminin G domain Syndecan PF01034.18 001271924.1_23526001_1 - 9.6e-08 31.7 0.0 2e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Syndecan domain CD34_antigen PF06365.10 001271924.1_23526001_1 - 0.018 14.5 0.1 0.028 13.9 0.1 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF202 PF02656.13 001271924.1_23526001_1 - 0.036 14.4 0.0 0.071 13.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Kinesin PF00225.21 001039312.2_23529001_3 - 9.7e-93 310.6 0.1 1.8e-92 309.7 0.1 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 001039312.2_23529001_3 - 2.3e-14 53.5 0.1 8.4e-14 51.6 0.0 1.9 2 0 0 2 2 2 1 Microtubule binding HMGL-like PF00682.17 001198714.1_23523001_3 - 3.7e-69 233.1 0.0 4.5e-69 232.8 0.0 1.1 1 0 0 1 1 1 1 HMGL-like ODC_AZ PF02100.15 194432.3_16125001_2 - 8e-19 67.6 0.0 1.2e-18 67.0 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme HMGL-like PF00682.17 001198716.1_23523001_3 - 1.4e-22 80.4 0.0 1.9e-22 80.0 0.0 1.1 1 0 0 1 1 1 1 HMGL-like zf-CCCH_3 PF15663.3 001031322.3_23528001_3 - 8.8e-08 32.3 6.8 0.00016 21.7 0.2 2.5 2 0 0 2 2 2 2 Zinc-finger containing family zf-CCCH PF00642.22 001031322.3_23528001_3 - 5.5e-07 29.2 28.0 0.00091 18.9 1.1 5.4 5 1 0 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 001031322.3_23528001_3 - 0.0027 18.0 27.4 0.92 10.0 1.6 5.7 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger Torus PF16131.3 001031322.3_23528001_3 - 0.22 12.1 18.7 5.7 7.5 0.3 4.3 2 2 2 4 4 4 0 Torus domain DUF1936 PF09151.8 001031322.3_23528001_3 - 1.3 8.9 4.2 20 5.0 0.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) PTN_MK_C PF01091.16 001276362.1_23529001_3 - 4.1e-26 91.0 9.3 4.1e-26 91.0 9.3 2.9 3 0 0 3 3 3 1 PTN/MK heparin-binding protein family, C-terminal domain PTN_MK_N PF05196.11 001276362.1_23529001_3 - 8.2e-25 86.7 17.2 2.5e-24 85.1 17.2 1.9 1 0 0 1 1 1 1 PTN/MK heparin-binding protein family, N-terminal domain HECT PF00632.23 001278155.1_23528001_3 - 1.6e-91 306.9 0.1 6.7e-91 304.8 0.0 1.9 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Ank_2 PF12796.5 001278155.1_23528001_3 - 1.1e-34 118.8 1.5 6.3e-12 45.8 0.2 4.0 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001278155.1_23528001_3 - 1.5e-32 111.4 4.0 4.9e-11 42.8 0.1 5.9 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 001278155.1_23528001_3 - 4.3e-27 91.0 2.4 1.8e-05 24.6 0.0 7.3 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.28 001278155.1_23528001_3 - 1.8e-26 91.2 11.1 1.5e-06 28.2 0.1 7.6 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.4 001278155.1_23528001_3 - 1.7e-23 82.2 4.1 1.6e-08 34.5 0.1 4.5 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Fe-S_biosyn PF01521.18 001271936.1_23526001_2 - 7.5e-19 67.8 0.0 1.1e-18 67.3 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Thioredoxin PF00085.18 204110.3_23524001_2 - 6.5e-67 221.9 0.0 1.3e-32 111.7 0.0 2.9 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.4 204110.3_23524001_2 - 7.1e-39 133.5 0.4 8.3e-32 110.5 1.5 2.8 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.4 204110.3_23524001_2 - 7.9e-09 35.6 0.0 0.0052 17.0 0.0 3.8 3 1 1 4 4 4 2 Thioredoxin-like Thioredoxin_2 PF13098.4 204110.3_23524001_2 - 1.8e-08 34.7 0.5 0.0041 17.4 0.1 3.5 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.4 204110.3_23524001_2 - 6.6e-07 29.3 0.0 0.027 14.5 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_4 PF13462.4 204110.3_23524001_2 - 3.9e-05 23.7 0.1 0.069 13.2 0.0 3.5 2 1 1 3 3 3 1 Thioredoxin AhpC-TSA PF00578.19 204110.3_23524001_2 - 8.3e-05 22.4 0.2 0.2 11.4 0.0 2.9 3 0 0 3 3 3 2 AhpC/TSA family Calsequestrin PF01216.15 204110.3_23524001_2 - 0.00017 20.7 0.0 0.00033 19.7 0.0 1.4 1 1 0 1 1 1 1 Calsequestrin OST3_OST6 PF04756.11 204110.3_23524001_2 - 0.00021 20.6 0.0 0.51 9.5 0.0 2.4 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.4 204110.3_23524001_2 - 0.028 14.3 0.2 0.81 9.6 0.0 2.8 3 0 0 3 3 3 0 Thioredoxin domain zf-RING_UBOX PF13445.4 001045025.2_16124001_2 - 2.5e-10 40.0 4.1 6.3e-10 38.8 4.1 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001045025.2_16124001_2 - 9.9e-08 31.6 2.3 9.9e-08 31.6 2.3 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001045025.2_16124001_2 - 4.1e-07 29.6 4.3 4.1e-07 29.6 4.3 2.7 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001045025.2_16124001_2 - 1.2e-06 28.4 7.4 1.2e-06 28.4 7.4 3.6 4 0 0 4 4 4 1 B-box zinc finger zf-RING_5 PF14634.4 001045025.2_16124001_2 - 2.6e-06 27.2 5.5 2.6e-06 27.2 5.5 2.7 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 001045025.2_16124001_2 - 9.8e-06 25.6 7.2 9.8e-06 25.6 7.2 2.6 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.4 001045025.2_16124001_2 - 1.3e-05 25.1 6.4 1.3e-05 25.1 6.4 2.8 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 001045025.2_16124001_2 - 3.8e-05 23.3 7.9 3.8e-05 23.3 7.9 3.1 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 001045025.2_16124001_2 - 0.0001 22.0 0.3 0.0001 22.0 0.3 2.3 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_11 PF17123.3 001045025.2_16124001_2 - 6.2 6.5 10.2 4.7 6.9 6.4 2.5 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_10 PF16685.3 001045025.2_16124001_2 - 8.7 6.4 13.4 0.4 10.7 3.4 3.0 3 1 0 3 3 3 0 zinc RING finger of MSL2 Fib_alpha PF08702.8 205356.2_23527001_1 - 3.5e-41 140.6 4.2 5.6e-41 139.9 4.2 1.3 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Fibrinogen_aC PF12160.6 205356.2_23527001_1 - 4.2e-22 77.7 2.9 1.1e-21 76.3 2.9 1.7 1 0 0 1 1 1 1 Fibrinogen alpha C domain DUF4407 PF14362.4 205356.2_23527001_1 - 0.33 10.1 2.8 0.57 9.3 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fibrinogen_C PF00147.16 205356.2_23527001_3 - 1.4e-70 237.4 3.1 1.8e-70 237.0 3.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain HH_signal PF01085.16 204821.1_23524001_1 - 5.4e-89 295.8 0.0 7.7e-89 295.3 0.0 1.2 1 0 0 1 1 1 1 Hedgehog amino-terminal signalling domain Hint PF01079.18 204821.1_23524001_1 - 1.1e-78 263.5 0.0 1.4e-78 263.2 0.0 1.1 1 0 0 1 1 1 1 Hint module Peptidase_M15_3 PF08291.9 204821.1_23524001_1 - 0.00048 20.0 0.0 0.00079 19.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase M15 Ribosomal_S6e PF01092.17 204821.1_23524001_1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S6e Histone_H2A_C PF16211.3 001005967.1_16122001_1 - 1.1e-20 72.9 2.0 1.1e-20 72.9 2.0 2.0 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.22 001005967.1_16122001_1 - 2.6e-16 60.1 0.0 3.6e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 001005967.1_16122001_1 - 9.9e-05 22.4 0.0 0.00015 21.8 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF4535 PF15054.4 001302634.1_16123001_2 - 3e-16 58.7 0.3 5e-16 58.0 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4535) Rdx PF10262.7 001006557.4_23524001_2 - 2.9e-10 40.0 0.0 6e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Rdx family Cupin_4 PF08007.10 001031196.1_23524001_3 - 1.6e-67 228.2 0.0 2.1e-67 227.8 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.4 001031196.1_23524001_3 - 1.3e-06 28.3 0.0 6.6e-05 22.7 0.0 2.2 1 1 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.9 001031196.1_23524001_3 - 0.0057 16.2 0.0 0.73 9.5 0.0 2.4 2 0 0 2 2 2 2 Cupin domain 7tm_1 PF00001.19 205195.1_23523001_3 - 1.1e-40 139.4 19.5 2.5e-40 138.3 19.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 205195.1_23523001_3 - 0.02 14.1 12.8 0.028 13.7 12.4 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv Pox_P21 PF05313.10 205195.1_23523001_3 - 1.5 8.3 6.0 3 7.3 4.6 2.2 1 1 1 2 2 2 0 Poxvirus P21 membrane protein Tfb5 PF06331.10 001097535.1_23523001_1 - 4.2e-27 93.9 0.2 5.9e-27 93.4 0.2 1.2 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Exo84_C PF16528.3 001006404.1_23526001_1 - 1.6e-57 194.6 1.2 2.1e-57 194.1 0.0 1.8 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.9 001006404.1_23526001_1 - 1.9e-17 63.0 2.5 5.5e-17 61.5 2.5 1.9 1 0 0 1 1 1 1 Vps51/Vps67 PH PF00169.27 001006404.1_23526001_1 - 0.00019 21.8 0.0 0.00053 20.3 0.0 1.8 2 0 0 2 2 2 1 PH domain Dor1 PF04124.10 001006404.1_23526001_1 - 0.011 14.3 8.4 0.082 11.4 0.1 3.1 3 0 0 3 3 3 0 Dor1-like family Syntaxin_2 PF14523.4 001006404.1_23526001_1 - 0.033 14.4 3.8 1 9.6 0.4 2.9 3 0 0 3 3 3 0 Syntaxin-like protein COG2 PF06148.9 001006404.1_23526001_1 - 0.4 10.6 5.5 0.13 12.2 0.8 2.6 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Adeno_terminal PF02459.13 001006404.1_23526001_1 - 0.45 8.7 5.2 0.82 7.8 5.2 1.3 1 0 0 1 1 1 0 Adenoviral DNA terminal protein SNF2_N PF00176.21 204710.1_23527001_2 - 7.8e-58 195.7 0.0 1.5e-57 194.8 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 204710.1_23527001_2 - 2.8e-17 62.9 0.0 1.4e-16 60.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 204710.1_23527001_2 - 3.5e-11 43.3 0.0 1.2e-10 41.6 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Ribonuclease_3 PF00636.24 001040465.1_23529001_1 - 8.1e-70 232.0 0.7 7.1e-44 148.6 0.0 3.3 3 1 0 3 3 3 2 Ribonuclease III domain PAZ PF02170.20 001040465.1_23529001_1 - 2.6e-39 134.0 0.6 1.3e-38 131.7 0.2 2.3 2 0 0 2 2 2 1 PAZ domain Dicer_dimer PF03368.12 001040465.1_23529001_1 - 6e-25 87.1 0.1 2.6e-24 85.1 0.0 2.2 2 0 0 2 2 2 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.4 001040465.1_23529001_1 - 1.5e-24 86.4 0.0 1.9e-16 60.3 0.0 3.7 3 1 0 3 3 3 2 Ribonuclease-III-like Helicase_C PF00271.29 001040465.1_23529001_1 - 7.5e-18 64.8 0.1 3e-17 62.9 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.27 001040465.1_23529001_1 - 5.5e-14 52.2 0.0 1.4e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.13 001040465.1_23529001_1 - 7.7e-14 51.9 0.0 2.3e-13 50.4 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.7 001040465.1_23529001_1 - 0.015 14.4 0.0 0.027 13.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) dsrm PF00035.24 001040465.1_23529001_1 - 0.059 13.9 0.0 0.26 11.9 0.0 2.2 1 0 0 1 1 1 0 Double-stranded RNA binding motif Flavi_DEAD PF07652.12 001040465.1_23529001_1 - 0.15 11.9 0.0 0.99 9.2 0.0 2.2 2 0 0 2 2 2 0 Flavivirus DEAD domain ART PF01129.16 001033646.1_23522001_1 - 8.1e-98 326.0 0.6 9.6e-98 325.8 0.6 1.0 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.12 001033646.1_23522001_1 - 0.00056 19.2 0.0 0.00096 18.4 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Guanylate_kin PF00625.19 130976.1_16129001_1 - 8.6e-47 159.0 0.7 3.1e-46 157.2 0.7 1.9 1 1 0 1 1 1 1 Guanylate kinase L27 PF02828.14 130976.1_16129001_1 - 3.1e-24 84.3 4.9 5.1e-13 48.4 0.6 2.4 2 0 0 2 2 2 2 L27 domain PDZ PF00595.22 130976.1_16129001_1 - 3.4e-09 36.8 1.1 6.3e-09 35.9 1.1 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SH3_2 PF07653.15 130976.1_16129001_1 - 3e-08 33.1 0.0 6e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 130976.1_16129001_1 - 2.9e-07 29.9 0.3 9e-07 28.3 0.3 1.9 1 1 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 130976.1_16129001_1 - 0.0055 16.4 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PDZ_2 PF13180.4 130976.1_16129001_1 - 0.0085 16.2 0.2 0.022 14.9 0.2 1.6 1 0 0 1 1 1 1 PDZ domain Trp_dioxygenase PF03301.11 001102616.2_16124001_1 - 8.3e-159 528.4 4.8 1e-158 528.1 4.8 1.1 1 0 0 1 1 1 1 Tryptophan 2,3-dioxygenase Ipi1_N PF12333.6 001031008.2_23527001_2 - 2.5e-21 76.0 1.1 2.5e-21 76.0 1.1 4.0 4 0 0 4 4 4 1 Rix1 complex component involved in 60S ribosome maturation HEAT_EZ PF13513.4 001031008.2_23527001_2 - 0.019 15.3 0.7 0.32 11.4 0.0 3.3 3 0 0 3 3 3 0 HEAT-like repeat Vac14_Fab1_bd PF12755.5 001031008.2_23527001_2 - 0.027 14.9 0.0 0.12 12.8 0.0 2.2 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region DUF2474 PF10617.7 001031008.2_23527001_2 - 1.7 8.4 5.6 2.8 7.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2474) Cytochrom_C PF00034.19 001079478.1_23521001_1 - 4.6e-13 50.0 0.0 6e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.4 001079478.1_23521001_1 - 4.2e-06 26.9 2.8 2e-05 24.7 2.8 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.4 001079478.1_23521001_1 - 0.00019 21.0 3.4 0.0021 17.6 3.4 2.3 1 1 0 1 1 1 1 Cytochrome c-550 domain Cmyb_C PF09316.8 205306.1_23525001_1 - 9.1e-74 246.5 2.5 1.7e-73 245.6 2.5 1.4 1 0 0 1 1 1 1 C-myb, C-terminal Myb_DNA-binding PF00249.29 205306.1_23525001_1 - 3.6e-54 180.6 19.9 7.6e-19 67.5 1.8 4.3 4 0 0 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 205306.1_23525001_1 - 9.1e-41 137.8 16.6 2.7e-17 62.6 1.2 3.5 1 1 2 3 3 3 3 Myb-like DNA-binding domain LMSTEN PF07988.10 205306.1_23525001_1 - 2e-26 91.0 0.5 3.8e-26 90.1 0.5 1.5 1 0 0 1 1 1 1 LMSTEN motif Myb_DNA-bind_7 PF15963.3 205306.1_23525001_1 - 6.5e-10 38.6 7.8 0.00022 20.9 0.1 4.0 2 1 2 4 4 4 2 Myb DNA-binding like SLIDE PF09111.8 205306.1_23525001_1 - 1.2e-06 28.3 0.2 1.1 9.2 0.0 4.1 2 1 2 4 4 4 3 SLIDE SANT_DAMP1_like PF16282.3 205306.1_23525001_1 - 0.00015 21.8 3.8 0.34 11.0 0.0 3.5 1 1 1 3 3 3 2 SANT/Myb-like domain of DAMP1 Rap1_C PF11626.6 205306.1_23525001_1 - 0.091 12.7 8.0 1.5 8.8 0.2 3.4 1 1 2 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Spore_III_AB PF09548.8 205306.1_23525001_1 - 0.3 11.0 3.2 0.61 10.1 0.1 2.9 3 0 0 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) 7tm_1 PF00001.19 204936.1_23525001_1 - 4.4e-29 101.4 25.1 7.8e-29 100.6 25.1 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.4 204936.1_23525001_1 - 5.7e-16 57.9 5.7 0.00077 19.1 1.0 4.7 2 2 3 5 5 5 5 Leucine rich repeat LRR_5 PF13306.4 204936.1_23525001_1 - 7.3e-12 45.2 0.2 6.8e-05 22.7 0.0 2.4 1 1 0 2 2 2 2 Leucine rich repeats (6 copies) GnHR_trans PF12369.6 204936.1_23525001_1 - 0.039 14.6 0.2 0.084 13.6 0.2 1.6 1 0 0 1 1 1 0 Gonadotropin hormone receptor transmembrane region LRR_4 PF12799.5 204936.1_23525001_1 - 0.15 12.4 10.0 0.81 10.0 0.5 3.6 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) DUF2800 PF10926.6 204936.1_23525001_2 - 0.19 10.8 2.3 0.28 10.2 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2800) LMBR1 PF04791.14 204172.1_23524001_2 - 8.9e-90 301.8 27.6 3.8e-55 187.6 14.7 2.0 1 1 1 2 2 2 2 LMBR1-like membrane protein FtsK_4TM PF13491.4 204172.1_23524001_2 - 0.0057 16.3 1.0 0.0057 16.3 1.0 3.1 3 1 0 3 3 3 1 4TM region of DNA translocase FtsK/SpoIIIE DUF912 PF06024.10 204172.1_23524001_2 - 0.0077 16.4 0.1 0.0077 16.4 0.1 3.6 4 0 0 4 4 4 2 Nucleopolyhedrovirus protein of unknown function (DUF912) Sigma_reg_N PF13800.4 204172.1_23524001_2 - 0.11 12.7 0.0 0.11 12.7 0.0 4.5 5 1 0 5 5 5 0 Sigma factor regulator N-terminal UPF0233 PF06781.10 204172.1_23524001_2 - 2.8 7.9 6.8 3 7.8 0.6 3.6 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0233) DUF3262 PF11660.6 204172.1_23524001_2 - 7.4 6.9 8.3 6.4 7.1 0.8 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF3262) DUF953 PF06110.9 001003456.1_16122001_1 - 7.5e-43 144.8 0.0 1.6e-42 143.7 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Methyltransf_2 PF00891.16 205343.1_23523001_3 - 1.1e-94 315.7 0.0 1.5e-94 315.3 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Dimerisation2 PF16864.3 205343.1_23523001_3 - 1.1e-33 114.9 0.0 2.1e-33 114.0 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_25 PF13649.4 205343.1_23523001_3 - 1.4e-07 32.0 0.0 2.5e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 205343.1_23523001_3 - 1.8e-06 28.4 0.0 3.6e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 205343.1_23523001_3 - 3.4e-06 27.6 0.0 6.2e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 205343.1_23523001_3 - 0.00016 21.4 0.0 0.00026 20.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Dimerisation PF08100.9 205343.1_23523001_3 - 0.0056 16.5 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain MTS PF05175.12 205343.1_23523001_3 - 0.081 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Ank_2 PF12796.5 181496.5_16127001_2 - 2.8e-14 53.3 0.0 5.8e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 181496.5_16127001_2 - 5.7e-11 42.6 0.2 2.1e-10 40.8 0.1 2.1 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.4 181496.5_16127001_2 - 4.3e-10 39.5 0.1 6.2e-09 35.8 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 181496.5_16127001_2 - 4e-07 29.7 0.0 0.01 16.2 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.28 181496.5_16127001_2 - 9.2e-07 28.9 0.0 0.051 13.9 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat DNA_pol_B_thumb PF14791.4 205389.1_23526001_2 - 3.4e-19 68.6 0.4 8.9e-19 67.2 0.4 1.8 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.7 205389.1_23526001_2 - 2.1e-16 59.4 0.0 3.6e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.4 205389.1_23526001_2 - 3.4e-13 49.6 0.0 9.8e-13 48.1 0.0 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_B_palm PF14792.4 205389.1_23526001_2 - 5.5e-08 32.9 0.0 1.2e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm BRCT PF00533.24 205389.1_23526001_2 - 1.8e-06 28.1 0.0 4.1e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain NTP_transf_2 PF01909.21 205389.1_23526001_2 - 6.1e-05 23.1 0.0 0.00013 22.1 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain BRCT_2 PF16589.3 205389.1_23526001_2 - 0.0031 17.8 0.0 0.0078 16.5 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Cdd1 PF11731.6 205389.1_23526001_2 - 0.0098 16.0 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 1 Pathogenicity locus CYSTM PF12734.5 001098766.1_16122001_1 - 2.2 8.6 65.3 4.2e+02 1.3 55.6 4.8 2 1 0 2 2 2 0 Cysteine-rich TM module stress tolerance Pentapeptide PF00805.20 001098766.1_16122001_2 - 0.029 13.9 0.1 0.044 13.3 0.1 1.2 1 0 0 1 1 1 0 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.4 001098766.1_16122001_2 - 0.035 14.1 0.0 0.057 13.4 0.0 1.2 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) GLTT PF01744.18 001098766.1_16122001_3 - 0.079 12.6 1.1 0.23 11.1 0.6 1.7 1 1 0 1 1 1 0 GLTT repeat (6 copies) ARL2_Bind_BART PF11527.6 001040322.1_16123001_2 - 6.7e-39 132.4 0.7 6.7e-39 132.4 0.7 1.7 2 0 0 2 2 2 1 The ARF-like 2 binding protein BART Biopterin_H PF00351.19 204956.1_23524001_2 - 7.3e-177 587.2 0.1 9.3e-177 586.9 0.1 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.23 204956.1_23524001_2 - 1.5e-06 27.7 0.1 4.1e-06 26.3 0.0 1.8 2 0 0 2 2 2 1 ACT domain DUF5031 PF16434.3 204956.1_23524001_2 - 0.031 13.2 0.0 0.047 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5031) AICARFT_IMPCHas PF01808.16 205178.1_23525001_2 - 9e-95 317.4 0.1 1.2e-94 316.9 0.1 1.2 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.20 205178.1_23525001_2 - 2.6e-24 85.1 0.0 5e-24 84.2 0.0 1.5 1 0 0 1 1 1 1 MGS-like domain Ribosomal_L12_N PF16320.3 205178.1_23525001_2 - 0.013 15.1 0.4 0.038 13.6 0.4 1.8 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain PucR PF07905.9 205178.1_23525001_2 - 0.12 12.5 0.0 8.2 6.6 0.0 3.1 3 0 0 3 3 3 0 Purine catabolism regulatory protein-like family Pkinase PF00069.23 001008635.1_16124001_2 - 5.4e-26 91.4 0.0 7.5e-26 90.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CK1gamma_C PF12605.6 001008635.1_16124001_2 - 1.9e-15 57.7 5.0 8.1e-09 36.4 0.4 2.7 1 1 1 2 2 2 2 Casein kinase 1 gamma C terminal Pkinase_Tyr PF07714.15 001008635.1_16124001_2 - 1.1e-13 51.0 0.0 1.5e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PIP49_C PF12260.6 001008635.1_16124001_2 - 0.094 12.2 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 Trp_dioxygenase PF03301.11 199856.1_16124001_3 - 6.2e-159 528.8 6.9 7.5e-159 528.5 6.9 1.1 1 0 0 1 1 1 1 Tryptophan 2,3-dioxygenase THF_DHG_CYH_C PF02882.17 001031360.1_23524001_2 - 8.6e-63 210.3 2.4 1.4e-62 209.6 2.4 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.21 001031360.1_23524001_2 - 1.2e-39 135.1 0.2 1.7e-39 134.6 0.2 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain AlaDh_PNT_C PF01262.19 001031360.1_23524001_2 - 0.055 12.6 0.2 0.083 12.0 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain LRR_8 PF13855.4 204209.1_23525001_1 - 1e-17 63.5 6.0 7.4e-07 28.7 0.0 3.6 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 204209.1_23525001_1 - 4.9e-11 42.5 9.8 0.0017 18.5 0.1 4.2 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 204209.1_23525001_1 - 0.095 13.1 8.5 23 5.9 0.8 5.6 5 1 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.4 204209.1_23525001_1 - 0.23 11.5 3.3 3.2 7.9 0.1 3.8 4 0 0 4 4 4 0 Leucine Rich repeat I-set PF07679.14 204874.1_23525001_3 - 2.8e-42 142.5 1.0 2.5e-15 56.2 0.0 3.5 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 204874.1_23525001_3 - 3.1e-41 139.7 2.5 2.5e-16 59.9 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 204874.1_23525001_3 - 1.4e-29 102.1 1.4 3.3e-12 46.4 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 204874.1_23525001_3 - 2.9e-27 94.5 1.6 2.1e-10 40.5 0.0 4.2 3 2 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 204874.1_23525001_3 - 1.1e-13 51.1 10.7 3e-06 27.2 0.1 5.8 4 3 1 5 5 5 3 Immunoglobulin V-set domain Ig_5 PF16681.3 204874.1_23525001_3 - 7.9e-10 38.9 0.7 0.068 13.5 0.0 4.1 4 1 0 4 4 4 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 204874.1_23525001_3 - 3.5e-07 30.0 1.1 0.016 15.1 0.1 3.6 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain Ig_4 PF16680.3 204874.1_23525001_3 - 1.8e-05 24.9 1.2 0.12 12.6 0.0 3.9 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.10 204874.1_23525001_3 - 1.9e-05 24.5 0.4 0.13 12.2 0.0 3.0 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain V-set_CD47 PF08204.9 204874.1_23525001_3 - 0.0011 18.9 0.2 1.1 9.1 0.0 2.9 3 0 0 3 3 3 2 CD47 immunoglobulin-like domain GSHPx PF00255.17 200222.1_16124001_3 - 1.3e-30 105.0 0.6 2.5e-30 104.1 0.0 1.7 2 0 0 2 2 2 1 Glutathione peroxidase AhpC-TSA PF00578.19 200222.1_16124001_3 - 0.0015 18.3 0.0 0.0029 17.4 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Serpin PF00079.18 205291.1_23527001_1 - 7.5e-100 334.7 0.7 9.3e-100 334.4 0.7 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) MAS20 PF02064.13 001002698.1_16123001_2 - 3.6e-46 156.3 0.1 6.3e-46 155.5 0.1 1.4 1 0 0 1 1 1 1 MAS20 protein import receptor GHBP PF12772.5 001001293.1_23525001_3 - 5.5e-135 449.6 13.7 6.8e-135 449.2 13.7 1.1 1 0 0 1 1 1 1 Growth hormone receptor binding EpoR_lig-bind PF09067.8 001001293.1_23525001_3 - 3e-13 49.7 3.1 3e-13 49.7 3.1 2.6 4 0 0 4 4 4 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 001001293.1_23525001_3 - 8.1e-07 29.2 0.2 1.9e-06 28.0 0.2 1.6 1 0 0 1 1 1 1 Fibronectin type III domain IL6Ra-bind PF09240.8 001001293.1_23525001_3 - 0.0027 18.0 1.7 0.0027 18.0 1.7 2.0 2 0 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding Nab6_mRNP_bdg PF10567.7 001001293.1_23525001_3 - 0.049 13.0 0.2 0.12 11.7 0.2 1.6 1 0 0 1 1 1 0 RNA-recognition motif Kazal_1 PF00050.19 001112662.1_23522001_1 - 9.6e-54 179.1 29.9 1.1e-19 70.0 4.1 3.2 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 001112662.1_23522001_1 - 7.5e-30 102.7 28.0 1e-10 41.5 4.2 3.4 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain DUF393 PF04134.10 001112662.1_23522001_1 - 4.9 8.4 7.9 10 7.3 0.7 3.1 3 0 0 3 3 3 0 Protein of unknown function, DUF393 Tubulin PF00091.23 001031598.1_23523001_1 - 1.2e-69 234.3 0.0 1.9e-69 233.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001031598.1_23523001_1 - 3.9e-42 143.3 0.1 6.1e-42 142.7 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 001031598.1_23523001_1 - 1.9e-06 28.0 0.1 5.6e-06 26.5 0.0 1.8 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.4 001031598.1_23523001_1 - 0.013 15.0 0.0 0.025 14.1 0.0 1.5 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.4 001031598.1_23523001_1 - 0.041 12.9 0.0 0.077 12.0 0.0 1.4 1 0 0 1 1 1 0 Tubulin like SR-25 PF10500.7 001080028.1_16125001_1 - 2.6 7.5 17.8 4.5 6.7 17.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MFS_1 PF07690.14 001080028.1_16125001_2 - 5.9e-27 94.4 36.5 3.4e-19 68.9 31.5 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Trypan_PARP PF05887.9 001080028.1_16125001_2 - 0.063 13.2 31.2 0.13 12.2 31.2 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF2868 PF11067.6 001080028.1_16125001_2 - 0.3 10.4 0.6 0.75 9.1 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2868) RabGAP-TBC PF00566.16 200487.1_16127001_1 - 6.6e-16 58.5 0.3 1.2e-15 57.6 0.3 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Rhodanese PF00581.18 200487.1_16127001_1 - 1.4e-06 28.6 0.0 2.6e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain BPL_LplA_LipB PF03099.17 001039993.1_16122001_1 - 1.3e-06 28.2 0.0 2.5e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family zf-H2C2_2 PF13465.4 001031595.1_23529001_3 - 2.5e-09 37.0 12.3 2e-06 27.9 4.0 6.9 7 0 0 7 7 7 2 Zinc-finger double domain zf-H2C2_5 PF13909.4 001031595.1_23529001_3 - 3.8e-08 32.8 34.2 0.0001 21.9 0.1 4.6 4 0 0 4 4 4 3 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 001031595.1_23529001_3 - 0.0052 17.0 54.9 0.31 11.4 7.9 7.2 6 0 0 6 6 6 4 Zinc finger, C2H2 type RGS PF00615.17 001002531.1_16123001_3 - 1.5e-38 131.5 1.3 2.6e-38 130.8 1.3 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain Histone PF00125.22 001017599.1_16123001_2 - 1.3e-53 180.8 1.7 1.7e-53 180.4 1.7 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.4 001017599.1_16123001_2 - 0.00035 20.5 0.0 0.00065 19.7 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.4 001017599.1_16123001_2 - 0.0015 18.7 0.0 0.0026 18.0 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.3 001017599.1_16123001_2 - 0.039 14.4 2.1 0.074 13.5 2.1 1.3 1 0 0 1 1 1 0 PCNA-associated factor Ank_2 PF12796.5 001089415.2_16128001_2 - 7.5e-109 356.4 38.2 7.5e-16 58.4 0.4 10.6 5 5 6 11 11 11 11 Ankyrin repeats (3 copies) Ank PF00023.28 001089415.2_16128001_2 - 3.8e-106 343.2 45.4 8e-08 32.3 0.1 17.6 17 0 0 17 17 17 15 Ankyrin repeat Ank_5 PF13857.4 001089415.2_16128001_2 - 1.7e-104 339.9 42.8 2e-12 47.0 0.3 15.1 5 5 10 15 15 15 14 Ankyrin repeats (many copies) Ank_4 PF13637.4 001089415.2_16128001_2 - 1.7e-101 331.3 26.6 3.6e-13 49.6 0.2 14.3 8 3 7 15 15 15 15 Ankyrin repeats (many copies) Ank_3 PF13606.4 001089415.2_16128001_2 - 6.9e-95 299.3 30.7 9.4e-07 28.6 0.1 18.7 18 0 0 18 18 18 16 Ankyrin repeat PARP PF00644.18 001089415.2_16128001_2 - 5.9e-27 94.5 3.5 1.1e-24 87.1 3.5 2.4 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain SAM_2 PF07647.15 001089415.2_16128001_2 - 3.5e-15 55.7 0.6 7.3e-15 54.7 0.6 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001089415.2_16128001_2 - 3.5e-13 49.7 0.7 7.6e-13 48.6 0.7 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Vps39_1 PF10366.7 001089415.2_16128001_2 - 0.045 13.9 0.1 13 6.0 0.1 3.1 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 ELM2 PF01448.22 001031292.1_23525001_3 - 4.7e-11 43.2 3.7 1.2e-10 41.8 0.0 2.8 2 0 0 2 2 2 1 ELM2 domain Myb_DNA-binding PF00249.29 001031292.1_23525001_3 - 1.9e-05 24.6 0.1 4.2e-05 23.5 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.3 001031292.1_23525001_3 - 0.012 15.3 0.6 0.036 13.8 0.0 2.1 2 0 0 2 2 2 0 Myb DNA-binding like Thioredoxin PF00085.18 001110387.1_16123001_2 - 2.7e-10 40.0 0.0 4.8e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Glypican PF01153.17 001037373.1_16127001_3 - 3.7e-221 735.6 0.0 4.8e-221 735.3 0.0 1.0 1 0 0 1 1 1 1 Glypican p450 PF00067.20 001001730.2_16125001_2 - 1.8e-75 254.4 0.0 2.3e-75 254.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 TIM PF00121.16 205451.1_23523001_1 - 1.2e-86 290.0 0.1 1.4e-86 289.7 0.1 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase HLH PF00010.24 204668.1_23522001_3 - 2.7e-18 65.5 0.1 3.9e-18 65.0 0.1 1.2 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DERM PF14704.4 204668.1_23522001_3 - 0.045 14.1 2.5 0.35 11.2 0.6 2.2 1 1 0 2 2 2 0 Dermatopontin DUF1295 PF06966.10 204668.1_23522001_3 - 0.13 11.6 0.1 0.19 11.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) Ipi1_N PF12333.6 212705.1_16126001_3 - 2.2e-22 79.4 0.1 2.2e-22 79.4 0.1 3.8 4 1 1 5 5 5 1 Rix1 complex component involved in 60S ribosome maturation HEAT_EZ PF13513.4 212705.1_16126001_3 - 0.0046 17.3 5.1 0.02 15.2 0.4 3.9 3 0 0 3 3 3 1 HEAT-like repeat HEAT_2 PF13646.4 212705.1_16126001_3 - 0.042 14.1 0.1 0.19 12.0 0.1 2.2 1 0 0 1 1 1 0 HEAT repeats Thoc2 PF11732.6 212705.1_16126001_3 - 0.11 12.4 0.1 0.44 10.5 0.1 2.1 1 0 0 1 1 1 0 Transcription- and export-related complex subunit Vac14_Fab1_bd PF12755.5 212705.1_16126001_3 - 0.12 12.9 0.0 0.47 10.9 0.0 2.1 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region HEAT PF02985.20 212705.1_16126001_3 - 0.14 12.4 1.6 1.7 9.0 0.2 3.5 3 0 0 3 3 3 0 HEAT repeat FGF PF00167.16 214808.1_16125001_1 - 1.8e-39 134.5 0.2 3e-39 133.8 0.2 1.3 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 214808.1_16125001_1 - 0.0025 17.9 0.0 0.0044 17.1 0.0 1.3 1 0 0 1 1 1 1 Fascin domain FRG1 PF06229.10 214808.1_16125001_1 - 0.028 14.0 0.0 0.042 13.4 0.0 1.2 1 0 0 1 1 1 0 FRG1-like domain DOG1 PF14144.4 001006402.1_23525001_1 - 0.045 13.8 0.3 0.091 12.8 0.3 1.4 1 0 0 1 1 1 0 Seed dormancy control Cation_efflux PF01545.19 001006402.1_23525001_3 - 2.5e-32 112.1 14.4 4.3e-32 111.3 14.4 1.4 1 0 0 1 1 1 1 Cation efflux family Thioredoxin PF00085.18 001002113.1_16125001_1 - 4.2e-10 39.4 0.0 7.5e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin CAP PF00188.24 001159977.1_16123001_2 - 1.8e-23 83.6 2.0 2.6e-23 83.1 2.0 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family dsrm PF00035.24 199997.1_16124001_1 - 2.6e-36 124.0 0.1 3.9e-15 56.2 0.0 3.5 3 0 0 3 3 3 3 Double-stranded RNA binding motif DND1_DSRM PF14709.5 199997.1_16124001_1 - 4.3e-14 52.4 0.5 9.1e-06 25.7 0.1 4.1 3 1 0 3 3 3 3 double strand RNA binding domain from DEAD END PROTEIN 1 Staufen_C PF16482.3 199997.1_16124001_1 - 4.2e-08 33.2 0.1 7.4e-07 29.2 0.0 2.3 2 0 0 2 2 2 1 Staufen C-terminal domain LPP20 PF02169.14 199997.1_16124001_1 - 0.29 11.4 0.8 1.8 8.8 0.0 2.5 3 0 0 3 3 3 0 LPP20 lipoprotein Cu2_monooxygen PF01082.18 204624.1_23525001_2 - 1.6e-48 164.1 1.6 3.6e-48 163.0 1.6 1.6 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain Cu2_monoox_C PF03712.13 204624.1_23525001_2 - 2e-43 147.5 0.0 3.6e-43 146.7 0.0 1.4 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain DOMON PF03351.15 204624.1_23525001_2 - 1.9e-28 99.0 0.0 3.5e-28 98.2 0.0 1.4 1 0 0 1 1 1 1 DOMON domain T-box PF00907.20 204144.1_23523001_1 - 4e-83 278.0 0.0 5.3e-83 277.6 0.0 1.2 1 0 0 1 1 1 1 T-box RmlD_sub_bind PF04321.15 001013474.2_16123001_2 - 7.9e-72 241.6 0.0 9.3e-72 241.4 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.19 001013474.2_16123001_2 - 5.2e-20 71.8 0.0 7.1e-20 71.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.13 001013474.2_16123001_2 - 8.2e-09 34.9 0.0 1.6e-06 27.3 0.0 2.7 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.3 001013474.2_16123001_2 - 8.9e-08 31.7 0.0 1.7e-07 30.8 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.10 001013474.2_16123001_2 - 2.3e-05 23.6 0.0 0.0016 17.5 0.0 2.6 2 1 0 2 2 2 1 Male sterility protein 3Beta_HSD PF01073.17 001013474.2_16123001_2 - 0.0043 15.9 0.0 0.046 12.6 0.0 2.2 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family EpoR_lig-bind PF09067.8 001279548.1_37525001_1 - 1.1e-27 96.2 0.0 2.4e-27 95.0 0.0 1.5 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding IL6Ra-bind PF09240.8 001279548.1_37525001_1 - 1.5e-09 38.0 0.1 3.3e-09 36.9 0.1 1.6 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding fn3 PF00041.19 001279548.1_37525001_1 - 1.5e-07 31.5 0.7 0.0002 21.5 0.0 2.7 2 1 0 2 2 2 2 Fibronectin type III domain zf-BED PF02892.13 001279548.1_37525001_3 - 0.079 12.9 1.6 0.17 11.8 1.6 1.5 1 0 0 1 1 1 0 BED zinc finger T4_deiodinase PF00837.15 204114.3_23529001_3 - 7.6e-103 342.7 0.0 1e-102 342.3 0.0 1.2 1 0 0 1 1 1 1 Iodothyronine deiodinase fn3 PF00041.19 001198712.1_23529001_1 - 1.7e-261 845.4 74.8 1.2e-19 70.3 0.4 17.3 17 0 0 17 17 17 17 Fibronectin type III domain fn1 PF00039.16 001198712.1_23529001_1 - 1e-146 476.7 167.7 5.1e-15 55.2 5.2 12.7 12 0 0 12 12 12 12 Fibronectin type I domain DUF2369 PF10179.7 001198712.1_23529001_1 - 1.7e-32 111.6 10.8 0.1 12.9 0.0 14.4 16 1 1 17 17 15 8 Uncharacterised conserved protein (DUF2369) fn2 PF00040.17 001198712.1_23529001_1 - 2.5e-31 107.5 29.4 1.3e-16 60.5 7.1 3.6 3 0 0 3 3 2 2 Fibronectin type II domain Pur_ac_phosph_N PF16656.3 001198712.1_23529001_1 - 3.7e-28 97.8 54.4 0.00045 20.6 0.0 19.8 16 6 1 17 17 17 8 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 001198712.1_23529001_1 - 1.3e-17 63.9 0.0 0.74 10.0 0.0 11.9 13 0 0 13 13 13 2 Interferon-alpha/beta receptor, fibronectin type III DUF4959 PF16323.3 001198712.1_23529001_1 - 4.7e-09 36.4 5.5 2.1 8.6 0.0 8.3 9 0 0 9 9 9 2 Domain of unknown function (DUF4959) DUF4912 PF16258.3 001198712.1_23529001_1 - 5e-07 29.8 0.0 4.3 7.5 0.0 7.0 9 0 0 9 9 9 2 Domain of unknown function (DUF4912) DUF1410 PF07198.9 001198712.1_23529001_1 - 0.00026 21.3 2.7 15 6.1 0.0 6.7 8 0 0 8 8 8 0 Protein of unknown function (DUF1410) Glyco_hydro_66 PF13199.4 001198712.1_23529001_1 - 0.0073 14.9 2.3 38 2.6 0.0 5.6 3 2 3 6 6 6 0 Glycosyl hydrolase family 66 fn3_2 PF16893.3 001198712.1_23529001_1 - 0.024 14.6 9.1 0.79 9.8 0.0 6.7 6 1 0 6 6 6 0 Fibronectin type III domain DUF2012 PF09430.8 001198712.1_23529001_1 - 0.062 13.3 0.0 28 4.7 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2012) C1-set PF07654.13 001206611.2_23523001_1 - 2.7e-10 40.4 0.0 7.3e-10 39.1 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001206611.2_23523001_1 - 9.5e-09 35.6 0.1 2e-08 34.6 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001206611.2_23523001_1 - 7.9e-08 32.2 0.0 1.4e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001206611.2_23523001_1 - 0.00032 20.6 0.0 0.00058 19.7 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 001206611.2_23523001_1 - 0.0089 16.2 0.0 0.038 14.2 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 001206611.2_23523001_1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.6 1 1 0 1 1 1 0 Immunoglobulin V-set domain Band_7 PF01145.23 001177735.1_23523001_2 - 1.1e-25 90.5 1.3 1.5e-25 90.1 1.3 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Med2 PF11214.6 001177735.1_23523001_2 - 0.008 16.2 0.4 0.016 15.2 0.4 1.5 1 0 0 1 1 1 1 Mediator complex subunit 2 WD40 PF00400.30 001279516.1_37523001_3 - 5.8e-50 166.1 23.9 1.4e-08 35.1 0.6 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001279516.1_37523001_3 - 2.3e-10 40.5 0.8 0.0041 17.2 0.0 4.5 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001279516.1_37523001_3 - 2.1e-05 24.4 0.2 0.0012 18.6 0.1 2.5 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 001279516.1_37523001_3 - 0.00049 19.0 0.1 2 7.2 0.0 4.0 2 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 001279516.1_37523001_3 - 0.0091 14.5 5.8 1.8 7.0 0.1 4.0 1 1 2 4 4 4 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.14 001279516.1_37523001_3 - 0.032 12.6 0.0 0.19 10.1 0.1 2.0 1 1 1 2 2 2 0 Cytochrome D1 heme domain WD40_like PF17005.3 001279516.1_37523001_3 - 0.057 12.6 0.0 3.4 6.8 0.0 2.3 2 0 0 2 2 2 0 WD40-like domain PD40 PF07676.10 001279516.1_37523001_3 - 0.098 12.5 0.1 18 5.3 0.0 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat LETM1 PF07766.11 001006461.2_23526001_2 - 7.6e-112 372.8 8.5 7.6e-112 372.8 8.5 3.8 2 1 1 4 4 4 1 LETM1-like protein SAP PF02037.25 001006461.2_23526001_2 - 0.00039 20.0 0.2 0.018 14.7 0.0 3.1 2 0 0 2 2 2 1 SAP domain EF-hand_6 PF13405.4 001006461.2_23526001_2 - 0.004 16.9 0.6 1.1 9.3 0.2 3.7 2 1 1 3 3 3 1 EF-hand domain EF-hand_1 PF00036.30 001006461.2_23526001_2 - 0.013 14.9 0.2 0.24 10.9 0.1 2.9 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.4 001006461.2_23526001_2 - 0.026 14.2 0.9 1.1 8.9 0.0 3.2 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_5 PF13202.4 001006461.2_23526001_2 - 0.052 13.0 0.3 0.27 10.7 0.3 2.3 1 0 0 1 1 1 0 EF hand Acetyltransf_11 PF13720.4 001006461.2_23526001_2 - 0.15 12.5 3.0 0.29 11.5 0.3 3.0 3 0 0 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 TolA_bind_tri PF16331.3 001006461.2_23526001_2 - 0.2 11.6 6.8 0.86 9.6 3.8 3.2 1 1 1 2 2 2 0 TolA binding protein trimerisation EF-hand_7 PF13499.4 001006461.2_23526001_2 - 0.21 11.9 0.1 0.21 11.9 0.1 3.2 3 1 0 3 3 3 0 EF-hand domain pair zf-C4 PF00105.16 001252221.2_23524001_2 - 8e-30 103.0 15.9 8e-30 103.0 15.9 2.4 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001252221.2_23524001_2 - 5.3e-17 62.0 0.1 1.4e-16 60.6 0.0 1.7 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor Ribosomal_L18 PF17135.2 001279463.1_37522001_3 - 6e-94 312.6 2.5 6.8e-94 312.4 2.5 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.17 001279463.1_37522001_3 - 0.11 13.0 0.0 0.2 12.3 0.0 1.5 1 1 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ribonuclease_3 PF00636.24 001161453.2_16129001_1 - 1.5e-70 234.4 0.0 7.1e-45 151.8 0.0 2.8 2 0 0 2 2 2 2 Ribonuclease III domain PAZ PF02170.20 001161453.2_16129001_1 - 5.2e-39 133.1 0.4 2.2e-38 131.0 0.3 2.1 2 0 0 2 2 2 1 PAZ domain Ribonucleas_3_3 PF14622.4 001161453.2_16129001_1 - 6.5e-24 84.4 0.0 2.7e-16 59.8 0.0 3.4 3 1 0 3 3 3 2 Ribonuclease-III-like Dicer_dimer PF03368.12 001161453.2_16129001_1 - 6.7e-24 83.8 0.0 2e-23 82.2 0.0 1.9 1 0 0 1 1 1 1 Dicer dimerisation domain Helicase_C PF00271.29 001161453.2_16129001_1 - 2e-17 63.4 0.0 5.3e-17 62.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 001161453.2_16129001_1 - 2e-11 44.1 0.0 4.4e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.27 001161453.2_16129001_1 - 2.6e-11 43.4 0.0 4.5e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase dsrm PF00035.24 001161453.2_16129001_1 - 0.098 13.2 0.1 0.41 11.2 0.0 2.1 2 0 0 2 2 2 0 Double-stranded RNA binding motif p450 PF00067.20 001279586.1_37524001_1 - 2.2e-81 273.8 0.4 2.8e-81 273.5 0.4 1.1 1 0 0 1 1 1 1 Cytochrome P450 zf-CCCH_3 PF15663.3 001163325.2_23528001_3 - 3.1e-07 30.5 9.3 0.00017 21.7 1.0 2.5 2 0 0 2 2 2 2 Zinc-finger containing family zf-CCCH PF00642.22 001163325.2_23528001_3 - 6e-07 29.1 28.0 0.00092 18.9 1.1 5.4 5 1 0 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 001163325.2_23528001_3 - 0.0029 17.9 27.4 0.93 9.9 1.6 5.7 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger Torus PF16131.3 001163325.2_23528001_3 - 0.21 12.1 18.6 5.4 7.6 0.3 4.3 2 2 2 4 4 4 0 Torus domain DUF1936 PF09151.8 001163325.2_23528001_3 - 1.3 8.8 4.2 21 5.0 0.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) DSPc PF00782.18 001281713.1_02223001_1 - 3e-29 101.4 0.0 3.9e-29 101.0 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.10 001281713.1_02223001_1 - 0.0048 17.1 0.0 0.0089 16.2 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.25 001281713.1_02223001_1 - 0.015 14.7 0.0 0.022 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DSPn PF14671.4 001281713.1_02223001_1 - 0.018 15.4 0.1 0.027 14.8 0.1 1.2 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half Xlink PF00193.15 204955.2_23529001_1 - 5.7e-122 398.3 15.8 1.8e-32 111.4 0.5 5.5 5 1 0 5 5 5 4 Extracellular link domain Lectin_C PF00059.19 204955.2_23529001_1 - 1e-21 77.5 16.5 1.4e-19 70.6 2.3 5.0 5 0 0 5 5 5 2 Lectin C-type domain V-set PF07686.15 204955.2_23529001_1 - 3.6e-09 36.6 0.0 7.7e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain Sushi PF00084.18 204955.2_23529001_1 - 7.8e-09 35.9 1.0 2e-08 34.6 1.0 1.8 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) EGF PF00008.25 204955.2_23529001_1 - 1.1e-05 25.4 4.0 1.1e-05 25.4 4.0 2.1 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.5 204955.2_23529001_1 - 2.7e-05 24.5 1.4 2.7e-05 24.5 1.4 2.7 3 0 0 3 3 3 1 Human growth factor-like EGF Pentapeptide_4 PF13599.4 204955.2_23529001_1 - 0.055 13.5 0.0 11 6.0 0.0 3.1 2 1 1 3 3 3 0 Pentapeptide repeats (9 copies) UL45 PF05473.10 204955.2_23529001_1 - 0.065 12.7 2.0 0.094 12.2 0.7 1.8 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like Chordopox_A33R PF05966.10 204955.2_23529001_1 - 0.071 12.2 3.1 1.8 7.7 0.1 3.9 5 0 0 5 5 5 0 Chordopoxvirus A33R protein EGF_CA PF07645.13 204955.2_23529001_1 - 0.079 13.0 9.3 0.13 12.4 7.7 2.3 2 0 0 2 2 2 0 Calcium-binding EGF domain Ntox14 PF15522.4 204955.2_23529001_1 - 0.088 12.1 0.2 4.6 6.5 0.0 3.2 1 1 1 3 3 3 0 Novel toxin 14 CTD PF12815.5 204955.2_23529001_1 - 0.1 13.0 27.3 4.7 7.7 3.0 6.6 2 1 5 7 7 6 0 Spt5 C-terminal nonapeptide repeat binding Spt4 T-box PF00907.20 001270878.1_23525001_1 - 4.3e-85 284.4 0.7 1.5e-84 282.7 0.4 1.8 2 0 0 2 2 2 1 T-box TBX PF12598.6 001270878.1_23525001_1 - 2.7e-23 82.4 5.2 2.7e-23 82.4 5.2 2.6 1 1 0 2 2 2 1 T-box transcription factor Transthyretin PF00576.19 205335.3_23522001_3 - 3.2e-20 72.7 0.1 4.5e-20 72.3 0.1 1.1 1 0 0 1 1 1 1 HIUase/Transthyretin family Insulin PF00049.16 205222.3_23522001_2 - 5.3e-24 84.9 2.1 7.5e-24 84.4 2.1 1.2 1 0 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 205222.3_23522001_2 - 0.082 12.8 5.6 0.83 9.6 0.2 2.3 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type MCM PF00493.21 001293169.1_23527001_2 - 8.8e-125 416.0 0.0 1.1e-124 415.7 0.0 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM_OB PF17207.1 001293169.1_23527001_2 - 2.7e-23 82.1 1.3 5e-23 81.2 1.3 1.4 1 0 0 1 1 1 1 MCM OB domain AAA_5 PF07728.12 001293169.1_23527001_2 - 5.2e-08 32.8 0.0 1.2e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.19 001293169.1_23527001_2 - 6e-08 32.2 0.0 9.8e-05 21.7 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.9 001293169.1_23527001_2 - 0.00021 21.1 0.0 0.00048 19.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.27 001293169.1_23527001_2 - 0.017 15.4 0.0 0.049 13.9 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 001293169.1_23527001_2 - 0.022 15.0 0.6 0.098 12.9 0.0 2.3 3 0 0 3 3 3 0 AAA ATPase domain Sigma54_activat PF00158.24 001293169.1_23527001_2 - 0.04 13.5 0.0 0.14 11.7 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain NTPase_1 PF03266.13 001293169.1_23527001_2 - 0.052 13.3 0.0 1.1 9.0 0.0 2.3 2 0 0 2 2 2 0 NTPase FtsK_SpoIIIE PF01580.16 001293169.1_23527001_2 - 0.053 12.7 0.0 0.16 11.2 0.0 1.7 1 0 0 1 1 1 0 FtsK/SpoIIIE family I-set PF07679.14 205116.2_23529001_3 - 1.8e-102 335.5 14.8 2.4e-16 59.4 0.0 8.8 8 1 0 8 8 8 8 Immunoglobulin I-set domain Ig_3 PF13927.4 205116.2_23529001_3 - 2.8e-71 236.0 0.6 4.9e-13 49.4 0.0 8.5 8 0 0 8 8 8 8 Immunoglobulin domain ig PF00047.23 205116.2_23529001_3 - 2.8e-41 139.4 3.3 1.8e-07 31.1 0.0 8.5 8 0 0 8 8 8 8 Immunoglobulin domain fn3 PF00041.19 205116.2_23529001_3 - 4.6e-39 132.5 0.6 1.3e-11 44.5 0.0 4.3 5 0 0 5 5 5 3 Fibronectin type III domain Ig_2 PF13895.4 205116.2_23529001_3 - 1.3e-33 115.1 0.0 5.3e-07 29.8 0.0 9.1 7 2 1 8 8 8 7 Immunoglobulin domain V-set PF07686.15 205116.2_23529001_3 - 9.9e-20 70.6 6.0 0.011 15.8 0.0 10.5 7 4 1 8 8 8 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 205116.2_23529001_3 - 9.8e-09 35.0 0.5 0.13 12.2 0.0 6.2 5 1 0 5 5 5 1 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.3 205116.2_23529001_3 - 0.0087 16.5 4.3 0.65 10.5 0.1 4.6 5 0 0 5 5 5 1 Purple acid Phosphatase, N-terminal domain PKD_3 PF16820.3 205116.2_23529001_3 - 0.028 14.0 7.1 0.31 10.7 0.1 4.6 5 0 0 5 5 5 0 PKD-like domain Myb_DNA-binding PF00249.29 001012807.2_23526001_3 - 4.5e-11 42.6 0.1 1.1e-10 41.4 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.15 001012807.2_23526001_3 - 1.3e-07 31.8 0.0 3.9e-07 30.2 0.0 1.8 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-bind_6 PF13921.4 001012807.2_23526001_3 - 2e-05 24.6 0.5 8.9e-05 22.5 0.1 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain MYO10_CC PF16735.3 001012807.2_23526001_3 - 0.68 9.9 3.9 0.25 11.3 0.9 1.9 2 0 0 2 2 2 0 Unconventional myosin-X coiled coil domain TGFb_propeptide PF00688.16 001031045.3_23529001_1 - 2.9e-35 122.1 0.1 4e-35 121.6 0.1 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001031045.3_23529001_1 - 2.7e-23 82.7 1.4 8.1e-23 81.2 1.4 1.9 1 0 0 1 1 1 1 Transforming growth factor beta like domain CLTH PF10607.7 199549.2_16126001_2 - 2.5e-31 108.4 0.2 3.9e-31 107.8 0.2 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Mic1 PF07035.10 199549.2_16126001_2 - 0.0058 16.3 0.3 0.013 15.2 0.1 1.6 2 0 0 2 2 2 1 Colon cancer-associated protein Mic1-like LisH PF08513.9 199549.2_16126001_2 - 0.097 12.6 0.0 0.31 11.0 0.0 2.0 1 0 0 1 1 1 0 LisH Kelch_1 PF01344.23 001320407.1_16128001_2 - 2.4e-34 116.5 28.8 1.9e-10 40.0 1.8 8.3 7 2 0 7 7 7 7 Kelch motif Kelch_6 PF13964.4 001320407.1_16128001_2 - 4.2e-33 112.4 11.4 6.8e-09 35.6 0.1 6.7 3 2 3 6 6 6 6 Kelch motif BACK PF07707.13 001320407.1_16128001_2 - 3.3e-29 100.9 1.5 3.3e-29 100.9 1.5 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.29 001320407.1_16128001_2 - 9.1e-28 96.6 0.5 1.6e-27 95.8 0.5 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_2 PF07646.13 001320407.1_16128001_2 - 4.9e-21 73.7 7.2 2e-06 27.4 0.2 6.8 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.4 001320407.1_16128001_2 - 8.9e-18 64.0 16.1 3.3e-05 23.9 0.4 5.9 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.4 001320407.1_16128001_2 - 3e-14 52.5 8.4 0.00066 19.5 0.3 6.8 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.4 001320407.1_16128001_2 - 0.0056 16.5 12.1 0.72 9.8 0.5 4.0 4 0 0 4 4 4 2 Kelch motif Frizzled PF01534.15 001271931.2_23529001_2 - 2.7e-118 394.6 17.7 3.9e-118 394.1 17.7 1.2 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.20 001271931.2_23529001_2 - 1.5e-25 89.9 7.7 1.5e-25 89.9 7.7 2.1 2 0 0 2 2 2 1 Fz domain PSRT PF07636.9 001271931.2_23529001_3 - 0.012 15.2 1.2 0.031 13.8 1.2 1.7 1 0 0 1 1 1 0 PSRT Pkinase PF00069.23 001305192.1_23526001_2 - 7.1e-34 117.2 0.0 9.3e-34 116.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001305192.1_23526001_2 - 3.5e-22 78.8 0.0 1.5e-21 76.8 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase fn3 PF00041.19 205276.3_23529001_1 - 2.8e-122 399.2 20.1 9.7e-16 57.8 0.1 9.3 9 0 0 9 9 9 9 Fibronectin type III domain Fibrinogen_C PF00147.16 205276.3_23529001_1 - 1.7e-80 269.8 7.7 2.7e-80 269.2 7.7 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Pur_ac_phosph_N PF16656.3 205276.3_23529001_1 - 9.3e-17 61.3 20.8 0.14 12.6 0.0 10.9 8 6 0 8 8 8 6 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 205276.3_23529001_1 - 5.8e-11 42.5 0.0 2.1 8.6 0.0 8.1 9 0 0 9 9 9 1 Interferon-alpha/beta receptor, fibronectin type III EGF_2 PF07974.11 205276.3_23529001_1 - 6.6e-11 42.3 89.7 0.0032 17.7 13.7 5.8 5 0 0 5 5 5 5 EGF-like domain DUF2369 PF10179.7 205276.3_23529001_1 - 1e-07 32.2 7.0 0.95 9.8 0.0 7.3 9 1 0 9 9 8 1 Uncharacterised conserved protein (DUF2369) fn3_2 PF16893.3 205276.3_23529001_1 - 7.8e-06 25.8 0.3 20 5.3 0.0 6.3 8 0 0 8 8 8 0 Fibronectin type III domain CBM_4_9 PF02018.15 205276.3_23529001_1 - 2e-05 24.7 0.5 11 6.1 0.1 5.7 4 1 1 5 5 5 0 Carbohydrate binding domain DUF4998 PF16389.3 205276.3_23529001_1 - 0.0019 17.7 0.0 3.4 7.1 0.0 4.5 5 0 0 5 5 5 1 Domain of unknown function DUF4959 PF16323.3 205276.3_23529001_1 - 0.025 14.8 0.2 8.8 6.6 0.0 4.4 4 1 1 5 5 5 0 Domain of unknown function (DUF4959) Uroplakin_II PF07353.10 205276.3_23529001_1 - 0.041 13.3 0.2 16 4.8 0.1 3.8 3 0 0 3 3 3 0 Uroplakin II Big_5 PF13205.4 205276.3_23529001_1 - 0.088 13.4 20.9 2.5 8.7 0.1 6.5 6 2 1 7 7 6 0 Bacterial Ig-like domain Lzipper-MIP1 PF14389.4 205276.3_23529001_1 - 0.12 12.5 0.1 0.32 11.2 0.1 1.6 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 DUF1192 PF06698.9 205276.3_23529001_1 - 0.45 10.5 1.7 0.61 10.1 0.0 2.0 2 0 0 2 2 1 0 Protein of unknown function (DUF1192) EGF PF00008.25 205276.3_23529001_1 - 1.8 8.8 75.7 1.6 8.9 11.8 5.8 5 0 0 5 5 5 0 EGF-like domain Pkinase PF00069.23 001305194.1_23526001_3 - 7.1e-34 117.2 0.0 9.3e-34 116.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001305194.1_23526001_3 - 3.5e-22 78.8 0.0 1.5e-21 76.8 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase GDA1_CD39 PF01150.15 204247.2_23525001_3 - 7e-109 364.2 0.0 9.7e-109 363.7 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family ADH_zinc_N PF00107.24 001305183.1_23525001_3 - 8.1e-27 93.6 0.2 1.5e-26 92.6 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001305183.1_23525001_3 - 2.6e-25 88.3 0.9 6.6e-25 87.0 0.9 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain UDPG_MGDP_dh_N PF03721.12 001305183.1_23525001_3 - 0.011 15.2 0.1 0.019 14.4 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ADH_zinc_N_2 PF13602.4 001305183.1_23525001_3 - 0.015 16.2 0.0 0.029 15.3 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.17 001305183.1_23525001_3 - 0.07 12.3 0.1 0.11 11.7 0.1 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.16 001305183.1_23525001_3 - 0.11 12.6 0.1 0.18 11.9 0.1 1.3 1 0 0 1 1 1 0 TrkA-N domain Cupin_8 PF13621.4 001305131.1_23523001_2 - 1.7e-43 149.1 0.1 2.3e-43 148.7 0.1 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.10 001305131.1_23523001_2 - 2.3e-10 40.3 0.0 3.3e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.20 001305131.1_23523001_2 - 0.01 16.1 0.0 0.02 15.2 0.0 1.5 1 0 0 1 1 1 0 JmjC domain, hydroxylase Amidase PF01425.19 204976.2_23525001_1 - 1.4e-118 396.7 0.0 1.7e-118 396.3 0.0 1.1 1 0 0 1 1 1 1 Amidase TPR_1 PF00515.26 001012818.2_23526001_1 - 3.8e-23 80.2 1.3 5.3e-06 25.9 0.0 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.15 001012818.2_23526001_1 - 2e-18 64.8 5.7 0.00026 20.7 0.4 5.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.4 001012818.2_23526001_1 - 6.6e-17 60.8 0.4 5.8e-05 22.6 0.1 4.8 3 1 2 5 5 5 3 TPR repeat TPR_8 PF13181.4 001012818.2_23526001_1 - 1.7e-15 55.7 0.1 0.0013 18.7 0.0 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.4 001012818.2_23526001_1 - 5.2e-15 55.7 2.5 5.5e-06 26.8 0.4 4.6 2 2 3 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.4 001012818.2_23526001_1 - 2.3e-14 52.7 6.7 0.017 15.8 0.2 6.5 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.4 001012818.2_23526001_1 - 1.6e-13 49.8 0.6 0.074 13.3 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.4 001012818.2_23526001_1 - 4.2e-11 43.1 1.9 0.0084 16.5 0.0 4.4 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.4 001012818.2_23526001_1 - 1.8e-09 37.6 5.5 0.00016 21.8 0.1 3.8 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.4 001012818.2_23526001_1 - 3.1e-08 33.0 0.2 0.63 10.1 0.0 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.4 001012818.2_23526001_1 - 1.4e-06 28.2 6.0 0.11 12.6 0.2 3.4 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.4 001012818.2_23526001_1 - 8.1e-06 26.0 1.0 0.96 9.7 0.0 4.4 3 2 2 5 5 4 2 Tetratricopeptide repeat TPR_10 PF13374.4 001012818.2_23526001_1 - 1.6e-05 24.5 2.8 0.094 12.5 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.4 001012818.2_23526001_1 - 5e-05 23.5 1.3 6.4 7.5 0.1 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.5 001012818.2_23526001_1 - 9e-05 22.5 2.9 0.088 12.9 0.1 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 Secretin_N_2 PF07655.11 001012818.2_23526001_1 - 0.092 13.2 0.1 0.22 12.0 0.1 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain DUF1641 PF07849.9 001012818.2_23526001_1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) MAS20 PF02064.13 001012818.2_23526001_1 - 0.13 12.2 0.0 15 5.6 0.0 3.0 1 1 1 2 2 2 0 MAS20 protein import receptor Pkinase_Tyr PF07714.15 205212.2_23529001_2 - 5.6e-93 310.8 0.0 8.2e-93 310.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Sema PF01403.17 205212.2_23529001_2 - 1.5e-58 198.4 3.0 1.5e-58 198.4 3.0 1.5 2 0 0 2 2 2 1 Sema domain Pkinase PF00069.23 205212.2_23529001_2 - 1.4e-38 132.6 0.0 2.5e-38 131.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain TIG PF01833.22 205212.2_23529001_2 - 2.7e-35 120.2 10.2 7.7e-15 54.6 0.1 4.8 4 0 0 4 4 4 4 IPT/TIG domain PSI PF01437.23 205212.2_23529001_2 - 2.9e-05 24.4 15.2 0.00022 21.5 15.2 2.7 1 0 0 1 1 1 1 Plexin repeat Kinase-like PF14531.4 205212.2_23529001_2 - 0.00021 20.6 0.0 0.00045 19.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Laminin_G_1 PF00054.21 205527.3_23529001_3 - 4.5e-110 363.2 0.0 4.6e-37 127.0 0.0 3.3 3 0 0 3 3 3 3 Laminin G domain Laminin_G_2 PF02210.22 205527.3_23529001_3 - 1.1e-69 232.7 0.0 2e-24 86.4 0.1 3.3 3 0 0 3 3 3 3 Laminin G domain Kazal_2 PF07648.13 205527.3_23529001_3 - 3.1e-69 228.8 87.5 3.6e-11 42.9 2.5 10.4 10 0 0 10 10 10 9 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 205527.3_23529001_3 - 3.2e-58 193.4 121.6 1.3e-11 44.1 0.1 10.6 10 0 0 10 10 10 9 Kazal-type serine protease inhibitor domain NtA PF03146.13 205527.3_23529001_3 - 8.7e-43 144.5 0.0 1.8e-42 143.5 0.0 1.6 1 0 0 1 1 1 1 Agrin NtA domain Laminin_EGF PF00053.22 205527.3_23529001_3 - 1.5e-18 66.5 32.0 7.4e-13 48.3 11.6 16.6 12 4 6 18 18 18 3 Laminin EGF domain SEA PF01390.18 205527.3_23529001_3 - 5.6e-17 61.8 0.1 1.1e-16 60.9 0.1 1.5 1 0 0 1 1 1 1 SEA domain EGF PF00008.25 205527.3_23529001_3 - 7.1e-14 51.7 51.3 3.6e-06 27.0 8.4 14.6 13 0 0 13 13 13 4 EGF-like domain Laminin_G_3 PF13385.4 205527.3_23529001_3 - 3e-09 37.1 0.0 0.00052 20.0 0.0 3.3 3 0 0 3 3 3 3 Concanavalin A-like lectin/glucanases superfamily hEGF PF12661.5 205527.3_23529001_3 - 0.0074 16.8 3.8 0.0074 16.8 3.8 16.1 17 0 0 17 17 17 4 Human growth factor-like EGF Homeobox PF00046.27 001308640.1_16124001_3 - 4.4e-19 67.9 6.3 7.7e-19 67.1 6.3 1.4 1 0 0 1 1 1 1 Homeobox domain Myc_N PF01056.16 001031091.2_23523001_1 - 4.6e-140 467.1 0.4 4.6e-140 467.1 0.4 1.4 2 0 0 2 2 2 1 Myc amino-terminal region HLH PF00010.24 001031091.2_23523001_1 - 1.3e-15 57.0 2.1 3.6e-15 55.5 2.1 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CENP-B_dimeris PF09026.8 001031091.2_23523001_1 - 0.0049 17.1 1.2 0.0049 17.1 1.2 1.7 2 0 0 2 2 2 1 Centromere protein B dimerisation domain ERCC4 PF02732.13 001031091.2_23523001_1 - 0.09 12.8 1.7 0.18 11.8 1.7 1.4 1 0 0 1 1 1 0 ERCC4 domain Myc-LZ PF02344.13 001031091.2_23523001_1 - 0.26 11.3 9.5 0.67 10.0 9.5 1.7 1 0 0 1 1 1 0 Myc leucine zipper domain PBP1_TM PF14812.4 001031091.2_23523001_1 - 2.3 8.5 6.4 0.31 11.4 1.2 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.4 001031091.2_23523001_1 - 2.7 7.5 5.8 1.2 8.7 1.1 2.2 2 0 0 2 2 2 0 FAM176 family Forkhead PF00250.16 205192.2_23525001_3 - 5.6e-37 125.8 0.0 9.3e-37 125.1 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain 7tm_1 PF00001.19 001291394.1_02228001_1 - 2.3e-44 151.5 11.1 2.3e-44 151.5 11.1 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Rhodopsin_N PF10413.7 001291394.1_02228001_1 - 6.6e-24 83.3 1.8 1.4e-23 82.2 1.8 1.6 1 0 0 1 1 1 1 Amino terminal of the G-protein receptor rhodopsin 7TM_GPCR_Srw PF10324.7 001291394.1_02228001_1 - 6.1e-12 45.3 12.2 1.8e-11 43.8 12.2 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.7 001291394.1_02228001_1 - 2.2e-06 27.1 15.6 3.8e-06 26.3 15.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv TAS2R PF05296.11 001291394.1_02228001_1 - 0.0011 18.1 1.0 0.0011 18.1 1.0 2.3 2 0 0 2 2 2 2 Taste receptor protein (TAS2R) 7tm_4 PF13853.4 001291394.1_02228001_1 - 0.1 12.2 13.0 0.61 9.6 13.0 2.0 1 1 0 1 1 1 0 Olfactory receptor DUF4407 PF14362.4 001291394.1_02228001_1 - 2.7 7.1 3.5 4.4 6.4 3.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) T4_deiodinase PF00837.15 001279513.2_37525001_1 - 6e-71 238.3 0.0 9.9e-71 237.6 0.0 1.3 1 0 0 1 1 1 1 Iodothyronine deiodinase Linker_histone PF00538.17 001277368.1_23522001_1 - 7.5e-22 77.4 0.7 7.5e-22 77.4 0.7 1.9 2 0 0 2 2 2 1 linker histone H1 and H5 family PRK PF00485.16 199764.2_16124001_3 - 1.2e-48 165.3 0.0 1.6e-48 165.0 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.4 199764.2_16124001_3 - 6.8e-06 26.5 0.0 1.2e-05 25.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain CoaE PF01121.18 199764.2_16124001_3 - 8.3e-06 25.4 0.1 2e-05 24.2 0.1 1.6 1 1 0 1 1 1 1 Dephospho-CoA kinase Zeta_toxin PF06414.10 199764.2_16124001_3 - 0.00037 19.7 0.0 0.00053 19.2 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.4 199764.2_16124001_3 - 0.045 14.0 1.2 0.13 12.6 1.2 1.7 1 1 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.16 199764.2_16124001_3 - 0.1 12.2 0.1 3.1 7.3 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase LTXXQ PF07813.10 199764.2_16124001_3 - 0.15 12.6 0.1 0.26 11.9 0.1 1.3 1 0 0 1 1 1 0 LTXXQ motif family protein Hira PF07569.9 204232.2_23528001_1 - 2e-57 194.4 0.3 4.5e-57 193.2 0.3 1.7 1 0 0 1 1 1 1 TUP1-like enhancer of split WD40 PF00400.30 204232.2_23528001_1 - 4.3e-28 96.9 34.9 3e-08 34.0 4.0 8.9 8 1 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 204232.2_23528001_1 - 6.3e-10 39.1 4.2 0.016 15.3 0.0 5.7 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.8 204232.2_23528001_1 - 6e-08 32.2 0.0 1.4e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 HIRA B motif Ribonuc_red_lgC PF02867.13 204232.2_23528001_1 - 0.018 13.4 0.7 0.027 12.9 0.7 1.1 1 0 0 1 1 1 0 Ribonucleotide reductase, barrel domain WD40_like PF17005.3 204232.2_23528001_1 - 0.12 11.6 0.0 0.69 9.0 0.0 2.0 2 0 0 2 2 2 0 WD40-like domain TFIIIC_delta PF12657.5 204232.2_23528001_1 - 0.14 12.0 3.1 0.61 9.8 0.0 3.3 3 1 0 3 3 3 0 Transcription factor IIIC subunit delta N-term RGM_C PF06534.11 204537.1_23523001_2 - 2e-71 238.9 0.0 2.7e-71 238.5 0.0 1.2 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus RGM_N PF06535.10 204537.1_23523001_2 - 2.7e-70 235.8 1.4 3.9e-70 235.2 1.4 1.2 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) N-terminus C8 PF08742.9 204537.1_23523001_2 - 1.8 8.9 5.8 2.7 8.4 0.0 2.9 3 0 0 3 3 3 0 C8 domain Ank_4 PF13637.4 204886.2_23528001_2 - 3.6e-15 56.0 0.1 2.7e-10 40.4 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 204886.2_23528001_2 - 4.1e-14 52.8 0.0 7.9e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 204886.2_23528001_2 - 1.5e-13 50.5 0.0 9.9e-09 35.2 0.0 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.28 204886.2_23528001_2 - 3.5e-11 42.9 0.2 2.1e-05 24.6 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.4 204886.2_23528001_2 - 3.7e-10 39.0 0.0 3e-05 24.0 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Gelsolin PF00626.20 001244593.1_23529001_3 - 5.2e-92 301.7 0.0 4.2e-18 64.9 0.0 6.3 6 0 0 6 6 6 6 Gelsolin repeat Neuro_bHLH PF12533.6 001309844.1_16124001_2 - 6.5e-40 137.1 0.9 1.2e-39 136.2 0.9 1.5 1 0 0 1 1 1 1 Neuronal helix-loop-helix transcription factor HLH PF00010.24 001309844.1_16124001_2 - 4.4e-15 55.3 0.6 7.2e-15 54.6 0.6 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.12 001309844.1_16124001_2 - 0.87 7.7 7.7 1.2 7.3 7.7 1.1 1 0 0 1 1 1 0 CDC45-like protein wnt PF00110.17 204336.2_23525001_2 - 5.3e-123 410.3 27.2 6.5e-123 410.0 27.2 1.1 1 0 0 1 1 1 1 wnt family Pkinase_Tyr PF07714.15 204749.2_23528001_2 - 1.1e-107 359.1 0.0 1.7e-107 358.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 204749.2_23528001_2 - 5.7e-44 150.3 0.0 7.5e-29 100.8 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 204749.2_23528001_2 - 5.8e-25 87.6 6.2 7.8e-07 29.5 0.1 5.6 5 0 0 5 5 5 4 Immunoglobulin domain I-set PF07679.14 204749.2_23528001_2 - 1.2e-20 73.2 6.6 5.6e-08 32.6 0.3 5.0 4 1 0 4 4 4 4 Immunoglobulin I-set domain ig PF00047.23 204749.2_23528001_2 - 7.5e-20 70.8 6.0 0.0001 22.3 0.0 5.8 5 0 0 5 5 5 4 Immunoglobulin domain Ig_2 PF13895.4 204749.2_23528001_2 - 8.5e-12 45.1 8.0 0.00016 21.8 0.1 5.8 5 2 0 5 5 5 3 Immunoglobulin domain V-set PF07686.15 204749.2_23528001_2 - 4.8e-05 23.4 4.6 0.038 14.0 0.2 4.9 4 2 0 4 4 4 1 Immunoglobulin V-set domain Herpes_gE PF02480.14 204749.2_23528001_2 - 0.0034 16.1 0.8 0.5 8.9 0.1 2.9 3 0 0 3 3 3 2 Alphaherpesvirus glycoprotein E Gypsy PF07253.9 204749.2_23528001_2 - 0.013 14.0 0.1 3.2 6.1 0.0 2.3 2 0 0 2 2 2 0 Gypsy protein Adeno_E3_CR1 PF02440.13 204749.2_23528001_2 - 0.087 12.5 2.4 1 9.0 0.2 3.2 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 C2-set_2 PF08205.10 204749.2_23528001_2 - 0.11 12.5 1.4 7.8 6.5 0.0 4.1 5 0 0 5 5 5 0 CD80-like C2-set immunoglobulin domain Acylphosphatase PF00708.16 001168005.2_23522001_1 - 2.7e-25 88.5 0.2 3.7e-25 88.0 0.2 1.2 1 0 0 1 1 1 1 Acylphosphatase Sushi PF00084.18 001319133.1_16124001_3 - 1.6e-31 108.5 23.3 3.7e-08 33.8 0.4 4.8 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) HRM PF02793.20 001319133.1_16124001_3 - 0.6 10.3 9.6 0.25 11.6 1.7 3.5 3 1 0 3 3 3 0 Hormone receptor domain cEGF PF12662.5 001319133.1_16124001_3 - 1.2 9.0 12.7 42 4.1 1.7 5.3 4 0 0 4 4 4 0 Complement Clr-like EGF-like FAM199X PF15814.3 201317.2_16125001_1 - 3.3 6.6 9.5 5 6.0 9.5 1.1 1 0 0 1 1 1 0 Protein family FAM199X YAF2_RYBP PF17219.1 201317.2_16125001_2 - 5.1e-19 67.3 0.5 1e-18 66.3 0.5 1.5 1 0 0 1 1 1 1 Yaf2/RYBP C-terminal binding motif zf-RanBP PF00641.16 201317.2_16125001_2 - 6.2e-07 28.5 3.8 6.2e-07 28.5 3.8 2.8 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others Androgen_recep PF02166.14 201317.2_16125001_2 - 0.22 10.2 12.9 0.4 9.3 12.9 1.5 1 0 0 1 1 1 0 Androgen receptor Sortilin-Vps10 PF15902.3 001305160.2_23529001_1 - 1.8e-113 379.6 0.0 2.6e-113 379.0 0.0 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.16 001305160.2_23529001_1 - 1.8e-110 360.7 207.3 5.6e-14 51.9 6.9 12.6 11 1 1 12 12 12 11 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.3 001305160.2_23529001_1 - 6.4e-40 137.1 0.1 6.4e-40 137.1 0.1 5.0 3 1 2 5 5 5 1 Sortilin, neurotensin receptor 3, C-terminal fn3 PF00041.19 001305160.2_23529001_1 - 4.3e-32 110.2 12.3 4.9e-09 36.3 0.1 6.5 6 0 0 6 6 6 5 Fibronectin type III domain Ldl_recept_b PF00058.15 001305160.2_23529001_1 - 3.4e-21 75.3 5.9 1.7e-05 25.1 0.1 5.7 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B Pur_ac_phosph_N PF16656.3 001305160.2_23529001_1 - 0.00015 22.2 11.8 0.11 12.9 0.0 5.3 6 0 0 6 6 6 2 Purple acid Phosphatase, N-terminal domain BNR_6 PF15899.3 001305160.2_23529001_1 - 0.00088 19.0 4.8 0.87 9.7 0.7 3.6 3 0 0 3 3 3 2 BNR-Asp box repeat Interfer-bind PF09294.8 001305160.2_23529001_1 - 0.0017 18.5 10.9 4.2 7.6 1.7 5.1 5 0 0 5 5 5 2 Interferon-alpha/beta receptor, fibronectin type III BNR PF02012.18 001305160.2_23529001_1 - 0.0032 17.1 15.2 3.5 7.9 0.2 5.7 5 0 0 5 5 5 1 BNR/Asp-box repeat Tissue_fac PF01108.15 001305160.2_23529001_1 - 0.35 10.6 8.8 2 8.1 1.9 4.4 3 1 1 4 4 4 0 Tissue factor Glypican PF01153.17 001305060.2_23528001_1 - 9.9e-236 783.7 0.8 1.5e-235 783.2 0.8 1.2 1 0 0 1 1 1 1 Glypican Homeobox PF00046.27 131422.3_16124001_2 - 3.8e-19 68.1 6.3 6.7e-19 67.3 6.3 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 131422.3_16124001_2 - 0.21 11.4 1.4 0.69 9.7 0.0 2.4 2 0 0 2 2 2 0 Homeobox KN domain Hydrolase PF00702.24 001305177.1_23526001_2 - 0.00025 21.3 0.0 0.00034 20.8 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Glyco_tranf_2_3 PF13641.4 204806.2_23526001_1 - 7.8e-19 68.4 0.1 2.6e-17 63.4 0.1 2.1 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.13 204806.2_23526001_1 - 2.8e-17 62.4 3.6 3.4e-14 52.2 0.6 3.3 2 1 0 2 2 2 2 Chitin synthase Glycos_transf_2 PF00535.24 204806.2_23526001_1 - 2.6e-08 33.7 0.0 0.00037 20.2 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.4 204806.2_23526001_1 - 4.2e-06 26.7 16.7 2.7e-05 24.0 16.7 2.3 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.4 204806.2_23526001_1 - 0.0055 16.1 0.0 0.012 15.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 21 MoCF_biosynth PF00994.22 001031549.2_23527001_2 - 1e-68 229.4 0.0 5.6e-41 139.4 0.0 2.3 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.15 001031549.2_23527001_2 - 8.2e-33 112.8 0.1 1.9e-32 111.6 0.1 1.6 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.13 001031549.2_23527001_2 - 2.9e-23 81.7 0.0 6.2e-23 80.6 0.0 1.6 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) Vert_HS_TF PF06546.9 001305256.1_23524001_1 - 1.5e-102 342.6 30.8 8.3e-84 281.2 12.0 2.9 2 1 1 3 3 3 2 Vertebrate heat shock transcription factor HSF_DNA-bind PF00447.15 001305256.1_23524001_1 - 1.4e-33 115.2 0.1 3e-33 114.1 0.1 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding ZapB PF06005.10 001305256.1_23524001_1 - 0.016 15.5 4.1 0.038 14.3 4.1 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DUF2813 PF11398.6 001305256.1_23524001_1 - 0.1 11.7 4.1 0.06 12.5 2.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2813) HMMR_C PF15908.3 001305256.1_23524001_1 - 0.9 9.7 9.8 2.2 8.4 1.2 2.3 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor C-terminal DUF972 PF06156.11 001305256.1_23524001_1 - 1.9 9.1 5.9 3.5 8.2 3.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF972) DUF724 PF05266.12 001305256.1_23524001_1 - 4.7 6.9 8.8 3.9 7.1 3.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF724) zf-RING_5 PF14634.4 001305034.1_23525001_3 - 7.6e-07 28.9 11.6 7.6e-07 28.9 11.6 3.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.23 001305034.1_23525001_3 - 4.8e-06 26.2 12.7 4.8e-06 26.2 12.7 3.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001305034.1_23525001_3 - 1.3e-05 25.2 13.0 1.3e-05 25.2 13.0 3.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.4 001305034.1_23525001_3 - 0.0003 20.6 10.7 0.0003 20.6 10.7 2.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_11 PF17123.3 001305034.1_23525001_3 - 0.00078 19.0 3.9 0.31 10.7 0.1 2.9 2 0 0 2 2 2 2 RING-like zinc finger zf-C3HC4_2 PF13923.4 001305034.1_23525001_3 - 0.0072 16.0 12.9 0.0072 16.0 12.9 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001305034.1_23525001_3 - 0.013 15.5 11.7 0.013 15.5 11.7 3.3 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING Myosin_head PF00063.19 001319304.1_23529001_1 - 1.1e-285 949.0 2.5 1.1e-285 949.0 2.5 3.4 5 0 0 5 5 5 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 001319304.1_23529001_1 - 6e-163 544.1 271.1 7.5e-163 543.8 271.1 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 001319304.1_23529001_1 - 5.5e-12 45.2 2.9 2e-11 43.4 2.9 2.1 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 001319304.1_23529001_1 - 1e-05 25.0 79.0 0.0099 15.2 4.4 9.2 1 1 11 12 12 12 9 Reovirus sigma C capsid protein BBP1_C PF15272.4 001319304.1_23529001_1 - 0.0023 17.7 16.4 0.0023 17.7 16.4 9.7 1 1 8 9 9 6 1 Spindle pole body component BBP1, C-terminal TSNAXIP1_N PF15739.3 001319304.1_23529001_1 - 0.0029 17.8 8.6 0.0029 17.8 8.6 15.1 2 2 13 15 15 10 2 Translin-associated factor X-interacting N-terminus IQ PF00612.25 001319304.1_23529001_1 - 0.015 14.9 1.3 0.077 12.7 0.2 2.5 2 0 0 2 2 2 0 IQ calmodulin-binding motif DUF1664 PF07889.10 001319304.1_23529001_1 - 0.058 13.2 162.4 0.079 12.8 9.1 14.1 2 2 9 14 14 14 0 Protein of unknown function (DUF1664) AAA_22 PF13401.4 001319304.1_23529001_1 - 0.09 12.9 0.0 0.09 12.9 0.0 5.0 3 2 2 5 5 5 0 AAA domain AAA_16 PF13191.4 001319304.1_23529001_1 - 0.39 10.9 0.0 0.39 10.9 0.0 5.8 3 2 0 3 3 1 0 AAA ATPase domain IncA PF04156.12 001319304.1_23529001_1 - 8 6.1 266.0 0.32 10.6 21.0 13.0 1 1 11 12 12 12 0 IncA protein Sec1 PF00995.21 001305648.1_23524001_3 - 6.9e-133 444.7 1.0 7.8e-133 444.5 1.0 1.0 1 0 0 1 1 1 1 Sec1 family YlbD_coat PF14071.4 001305648.1_23524001_3 - 0.051 13.7 0.9 0.15 12.1 0.9 1.8 1 0 0 1 1 1 0 Putative coat protein Globin PF00042.20 131020.2_16122001_3 - 2.6e-27 95.4 0.0 5.1e-27 94.5 0.0 1.5 2 0 0 2 2 2 1 Globin RRM_1 PF00076.20 001002562.2_16125001_2 - 1.2e-51 172.2 0.0 3.6e-16 58.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 001002562.2_16125001_2 - 5.2e-05 23.0 0.0 0.11 12.3 0.0 3.8 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.3 001002562.2_16125001_2 - 6.4e-05 22.9 0.0 0.13 12.3 0.0 3.5 3 0 0 3 3 3 1 RNA recognition motif TF_Otx PF03529.11 001002562.2_16125001_2 - 2.1 8.7 13.0 8.1 6.8 2.4 2.8 2 0 0 2 2 2 0 Otx1 transcription factor Kelch_1 PF01344.23 001143670.1_23525001_2 - 3.2e-40 135.3 7.0 3.7e-11 42.3 0.0 5.5 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.4 001143670.1_23525001_2 - 6.5e-34 115.0 4.2 1.8e-08 34.2 0.2 6.1 3 2 2 5 5 5 5 Kelch motif BTB PF00651.29 001143670.1_23525001_2 - 1.7e-23 82.8 1.9 1.7e-23 82.8 1.9 2.0 3 0 0 3 3 3 1 BTB/POZ domain Kelch_4 PF13418.4 001143670.1_23525001_2 - 1.5e-20 72.8 0.9 0.004 17.0 0.0 6.1 5 1 0 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.4 001143670.1_23525001_2 - 5.8e-18 64.6 0.5 8.1e-05 22.7 0.0 5.7 5 0 0 5 5 5 4 Galactose oxidase, central domain BACK PF07707.13 001143670.1_23525001_2 - 4.4e-16 58.7 0.1 1.1e-15 57.4 0.1 1.7 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_2 PF07646.13 001143670.1_23525001_2 - 4.7e-14 51.6 10.0 0.0015 18.3 0.0 6.1 6 1 0 6 6 6 4 Kelch motif Kelch_5 PF13854.4 001143670.1_23525001_2 - 3.7e-08 33.0 8.1 0.17 11.8 0.0 5.3 5 0 0 5 5 5 4 Kelch motif S_100 PF01023.17 205166.2_23522001_3 - 7.2e-18 63.9 0.2 7.2e-18 63.9 0.2 1.5 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.30 205166.2_23522001_3 - 2.1e-07 29.8 1.8 5.9e-06 25.3 0.3 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.4 205166.2_23522001_3 - 9.1e-06 25.9 0.3 1.5e-05 25.2 0.3 1.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 205166.2_23522001_3 - 2.1e-05 23.7 2.3 0.0013 18.1 0.3 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 205166.2_23522001_3 - 0.00038 20.1 0.8 0.16 11.9 0.2 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.4 205166.2_23522001_3 - 0.00039 20.0 0.7 0.00095 18.8 0.7 1.6 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_11 PF08976.9 205166.2_23522001_3 - 0.011 16.5 0.0 0.015 16.0 0.0 1.2 1 0 0 1 1 1 0 EF-hand domain EF-hand_4 PF12763.5 205166.2_23522001_3 - 0.039 13.8 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Basic PF01586.14 204214.2_23524001_2 - 3.1e-29 101.8 1.4 9.7e-29 100.2 1.4 1.9 1 0 0 1 1 1 1 Myogenic Basic domain Myf5 PF12232.6 204214.2_23524001_2 - 2.6e-24 85.6 11.7 2.6e-24 85.6 11.7 2.3 2 0 0 2 2 2 1 Myogenic determination factor 5 HLH PF00010.24 204214.2_23524001_2 - 1.2e-14 53.9 3.4 2.3e-14 52.9 3.4 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Oest_recep PF02159.13 001290517.1_02225001_2 - 8.9e-65 217.2 7.7 8.9e-65 217.2 7.7 2.0 2 0 0 2 2 2 1 Oestrogen receptor Hormone_recep PF00104.28 001290517.1_02225001_2 - 9.8e-33 113.4 2.1 1.6e-32 112.7 2.1 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001290517.1_02225001_2 - 1.6e-31 108.4 13.9 3.2e-31 107.5 13.9 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) ESR1_C PF12743.5 001290517.1_02225001_2 - 4.1e-16 58.3 0.5 4.1e-16 58.3 0.5 2.2 2 0 0 2 2 2 1 Oestrogen-type nuclear receptor final C-terminal DSPc PF00782.18 001168006.1_23522001_2 - 6e-31 106.9 0.0 7.9e-31 106.5 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 001168006.1_23522001_2 - 0.0016 18.0 0.0 0.0023 17.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.10 001168006.1_23522001_2 - 0.003 17.7 0.0 0.0063 16.7 0.0 1.5 1 1 0 1 1 1 1 Rit1 DUSP-like domain DSPn PF14671.4 001168006.1_23522001_2 - 0.0042 17.4 0.0 0.0061 16.9 0.0 1.2 1 0 0 1 1 1 1 Dual specificity protein phosphatase, N-terminal half PTPlike_phytase PF14566.4 001168006.1_23522001_2 - 0.06 13.4 0.0 0.089 12.8 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate Neur_chan_memb PF02932.14 001031568.2_23524001_1 - 2.9e-72 243.5 0.4 3.7e-72 243.1 0.4 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 001031568.2_23524001_1 - 3.8e-71 238.8 3.6 5.7e-71 238.2 3.6 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain zf-H2C2_2 PF13465.4 001353866.1_16129001_1 - 3.2e-23 80.9 70.4 3.9e-07 30.1 0.9 11.6 12 0 0 12 12 12 6 Zinc-finger double domain zf-H2C2_5 PF13909.4 001353866.1_16129001_1 - 2.6e-14 52.5 76.6 1.6e-06 27.6 4.3 10.7 12 0 0 12 12 12 5 C2H2-type zinc-finger domain Nrf1_DNA-bind PF10491.7 131680.2_16126001_3 - 1.2e-114 381.1 0.0 1.7e-114 380.7 0.0 1.2 1 0 0 1 1 1 1 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Nrf1_activ_bdg PF10492.7 131680.2_16126001_3 - 0.0012 19.3 5.3 0.0012 19.3 5.3 4.2 3 2 0 3 3 3 1 Nrf1 activator activation site binding domain DUF1341 PF07071.9 131680.2_16126001_3 - 3.5 7.2 12.6 0.58 9.8 3.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1341) PGAP1 PF07819.11 001030286.1_16125001_1 - 0.0005 19.7 0.0 0.0013 18.4 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.5 001030286.1_16125001_1 - 0.001 19.6 0.0 0.0033 17.9 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Arm PF00514.21 001030286.1_16125001_1 - 0.0083 16.0 0.1 1.1 9.3 0.1 2.8 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat Hydrolase_4 PF12146.6 001030286.1_16125001_1 - 0.015 14.4 0.0 0.083 12.0 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 HEAT_2 PF13646.4 001030286.1_16125001_1 - 0.037 14.3 1.3 0.89 9.8 0.1 2.6 2 0 0 2 2 2 0 HEAT repeats DnaJ PF00226.29 001079993.1_16125001_1 - 5.2e-29 100.0 4.0 9.7e-29 99.2 4.0 1.5 1 0 0 1 1 1 1 DnaJ domain UIM PF02809.18 001079993.1_16125001_1 - 0.0013 18.4 16.6 0.0039 16.9 5.0 2.6 2 0 0 2 2 2 2 Ubiquitin interaction motif DEAD PF00270.27 001123323.1_16126001_2 - 1.2e-33 116.2 0.1 2.6e-33 115.1 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001123323.1_16126001_2 - 1.6e-23 83.0 0.0 1e-22 80.5 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 001123323.1_16126001_2 - 2.9e-06 27.3 0.2 2.8e-05 24.1 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.4 001123323.1_16126001_2 - 0.0076 15.8 0.0 0.017 14.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain CMS1 PF14617.4 001123323.1_16126001_2 - 0.015 14.5 1.6 0.02 14.1 0.0 1.9 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit AAA_19 PF13245.4 001123323.1_16126001_2 - 0.041 14.1 0.0 0.097 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF2399 PF09664.8 001123323.1_16126001_2 - 0.12 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2399) T4_deiodinase PF00837.15 001122648.2_23524001_1 - 1.3e-94 315.7 0.0 1.7e-94 315.4 0.0 1.1 1 0 0 1 1 1 1 Iodothyronine deiodinase PAP2 PF01569.19 001328338.1_16124001_3 - 1e-16 60.8 5.6 1.9e-16 60.0 5.6 1.4 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.4 001328338.1_16124001_3 - 2.9e-06 27.0 6.3 5.5e-06 26.1 6.3 1.5 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.4 001328338.1_16124001_3 - 0.03 14.7 0.6 0.089 13.2 0.6 1.8 1 0 0 1 1 1 0 PAP2 superfamily C-terminal FAM176 PF14851.4 001076587.2_16125001_3 - 3.4e-59 198.5 0.1 4.9e-59 198.0 0.1 1.2 1 0 0 1 1 1 1 FAM176 family MFS_1 PF07690.14 001045229.1_16125001_2 - 1.2e-25 90.1 45.0 4.9e-17 61.8 23.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 001045229.1_16125001_2 - 2e-22 79.6 35.1 2.2e-19 69.6 9.4 2.5 2 1 0 2 2 2 2 Sugar (and other) transporter SWIRM PF04433.15 001164029.1_16128001_1 - 9.2e-23 80.3 0.0 2e-22 79.2 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.29 001164029.1_16128001_1 - 1.6e-11 44.1 0.3 6.1e-11 42.2 0.3 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain JAB PF01398.19 001164029.1_16128001_1 - 4.6e-10 39.4 0.0 9.6e-10 38.3 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.4 001164029.1_16128001_1 - 3.1e-07 30.0 0.0 6.9e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Myb_DNA-bind_7 PF15963.3 001164029.1_16128001_1 - 0.001 18.7 0.5 0.0036 17.0 0.0 2.2 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.4 001164029.1_16128001_1 - 0.0037 17.4 1.2 0.011 15.8 0.1 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain eIF3_N PF09440.8 001044951.1_16124001_1 - 4.3e-47 159.7 4.7 4.3e-47 159.7 4.7 1.9 2 0 0 2 2 2 1 eIF3 subunit 6 N terminal domain PCI PF01399.25 001044951.1_16124001_1 - 7.9e-18 64.8 0.1 2.4e-17 63.2 0.1 1.8 1 0 0 1 1 1 1 PCI domain TPR_3 PF07720.10 001044951.1_16124001_1 - 5.7 6.9 7.8 2.7 7.9 2.9 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_12 PF13087.4 001044342.2_16127001_3 - 2.8e-52 177.1 0.1 5e-52 176.3 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.4 001044342.2_16127001_3 - 1.5e-29 103.4 0.8 3.3e-16 59.7 0.1 3.1 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.4 001044342.2_16127001_3 - 9.4e-15 54.7 0.0 3.1e-14 53.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.4 001044342.2_16127001_3 - 8.7e-12 45.5 0.0 1.5e-10 41.5 0.0 2.6 2 1 0 2 2 2 1 AAA domain ResIII PF04851.13 001044342.2_16127001_3 - 3.6e-07 30.2 0.0 1.3e-06 28.4 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UvrD_C PF13361.4 001044342.2_16127001_3 - 0.00048 19.5 0.6 0.038 13.2 0.0 2.6 1 1 0 2 2 2 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.19 001044342.2_16127001_3 - 0.0013 18.2 0.1 0.03 13.7 0.0 2.9 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.4 001044342.2_16127001_3 - 0.0087 16.3 0.0 0.031 14.5 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.27 001044342.2_16127001_3 - 0.022 15.1 0.0 0.069 13.4 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 001044342.2_16127001_3 - 0.023 14.9 0.0 0.09 12.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain PhoH PF02562.14 001044342.2_16127001_3 - 0.045 13.1 0.0 0.12 11.6 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein T2SSE PF00437.18 001044342.2_16127001_3 - 0.1 11.5 0.0 0.19 10.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein UvrD_C_2 PF13538.4 001044342.2_16127001_3 - 0.1 12.3 0.1 0.39 10.4 0.1 2.0 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain CwfJ_C_1 PF04677.13 001044758.1_16124001_2 - 6.1e-33 113.1 0.1 1.2e-32 112.2 0.1 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.12 001044758.1_16124001_2 - 1.5e-15 57.8 1.1 2.5e-15 57.0 0.1 1.9 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 Metallophos_3 PF14582.4 001044758.1_16124001_2 - 0.014 14.6 0.0 0.028 13.6 0.0 1.5 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily SH3_9 PF14604.4 001045216.1_16123001_1 - 3.3e-17 61.9 0.7 7.8e-17 60.7 0.3 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 001045216.1_16123001_1 - 2.1e-15 55.9 0.1 4.7e-15 54.8 0.1 1.7 1 0 0 1 1 1 1 SH3 domain FCH PF00611.21 001045216.1_16123001_1 - 3.6e-12 46.2 3.4 4.2e-12 46.0 0.0 2.8 3 1 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.15 001045216.1_16123001_1 - 4.2e-12 45.4 0.1 7.5e-12 44.6 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 001045216.1_16123001_1 - 0.021 15.0 1.3 0.041 14.0 1.3 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain Tir_receptor_N PF07490.9 001045216.1_16123001_1 - 0.037 13.7 1.1 0.044 13.5 0.0 1.6 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) N-terminus ArAE_2 PF10334.7 001045216.1_16123001_1 - 0.043 13.5 0.1 0.086 12.5 0.1 1.4 1 0 0 1 1 1 0 Aromatic acid exporter family member 2 Alanine_zipper PF11839.6 001045216.1_16123001_1 - 0.98 9.6 11.4 0.42 10.8 7.4 2.3 1 1 2 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein Mt_ATP-synt_D PF05873.10 001045216.1_16123001_1 - 1.4 8.7 13.4 1.8 8.3 12.6 1.6 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) DUF2894 PF11445.6 001045216.1_16123001_1 - 2.1 8.6 8.4 3.6 7.9 8.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) Bombesin PF02044.15 001082922.1_16122001_1 - 1.6e-08 33.9 3.1 3e-08 33.0 3.1 1.5 1 0 0 1 1 1 1 Bombesin-like peptide UPF0688 PF15772.3 001044837.1_16122001_3 - 1.8e-22 80.6 0.7 2.2e-22 80.3 0.7 1.1 1 0 0 1 1 1 1 UPF0688 family Dynamitin PF04912.12 001347945.1_23523001_1 - 7e-131 437.0 14.9 7.9e-131 436.8 14.9 1.0 1 0 0 1 1 1 1 Dynamitin Pou PF00157.15 001347945.1_23523001_1 - 0.064 13.1 0.6 0.33 10.9 0.2 2.5 2 0 0 2 2 2 0 Pou domain - N-terminal to homeobox domain LPP PF04728.11 001347945.1_23523001_1 - 0.66 10.3 4.2 1.3 9.3 0.3 3.0 2 0 0 2 2 2 0 Lipoprotein leucine-zipper KxDL PF10241.7 001347945.1_23523001_1 - 2.4 8.4 8.9 3.4 7.9 1.0 3.5 3 0 0 3 3 3 0 Uncharacterized conserved protein TRPM_tetra PF16519.3 001347945.1_23523001_1 - 3.3 7.8 11.0 3.6 7.6 0.2 4.3 5 0 0 5 5 5 0 Tetramerisation domain of TRPM BIR PF00653.19 194397.3_16123001_1 - 3.9e-23 81.8 0.6 8.8e-23 80.7 0.6 1.6 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain BROMI PF14961.4 001100023.1_16128001_1 - 0 2329.0 12.1 0 2328.8 12.1 1.0 1 0 0 1 1 1 1 Broad-minded protein RD3 PF14473.4 001100023.1_16128001_1 - 0.22 11.3 2.3 0.56 9.9 2.3 1.7 1 0 0 1 1 1 0 RD3 protein UBN_AB PF14075.4 001100023.1_16128001_1 - 0.72 9.4 5.5 0.88 9.2 2.6 2.4 2 0 0 2 2 2 0 Ubinuclein conserved middle domain Filament PF00038.19 001048076.2_23525001_2 - 2.2e-113 378.9 50.9 2.6e-113 378.6 50.9 1.1 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.12 001048076.2_23525001_2 - 1.3e-18 67.5 11.1 2.3e-18 66.7 11.1 1.4 1 0 0 1 1 1 1 Intermediate filament head (DNA binding) region DUF1664 PF07889.10 001048076.2_23525001_2 - 0.00022 21.1 18.7 0.0037 17.1 1.2 3.5 2 1 0 3 3 3 2 Protein of unknown function (DUF1664) Reo_sigmaC PF04582.10 001048076.2_23525001_2 - 0.00061 19.2 6.4 0.035 13.4 0.3 2.5 1 1 2 3 3 3 2 Reovirus sigma C capsid protein DUF4515 PF14988.4 001048076.2_23525001_2 - 0.0079 16.0 43.5 0.036 13.8 11.9 2.9 1 1 2 3 3 3 2 Domain of unknown function (DUF4515) DUF4200 PF13863.4 001048076.2_23525001_2 - 0.014 15.7 15.7 0.014 15.7 15.7 3.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) FPP PF05911.9 001048076.2_23525001_2 - 0.02 13.0 34.1 0.019 13.1 16.5 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil TPR_MLP1_2 PF07926.10 001048076.2_23525001_2 - 0.049 13.6 52.7 0.14 12.1 14.1 4.1 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein Golgin_A5 PF09787.7 001048076.2_23525001_2 - 0.16 11.3 42.6 0.89 8.8 22.2 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 Jnk-SapK_ap_N PF09744.7 001048076.2_23525001_2 - 0.38 10.8 45.6 0.39 10.8 16.6 3.8 1 1 0 3 3 3 0 JNK_SAPK-associated protein-1 Laminin_II PF06009.10 001048076.2_23525001_2 - 0.41 10.5 26.9 2.6 7.9 1.4 3.5 1 1 1 3 3 3 0 Laminin Domain II Atg14 PF10186.7 001048076.2_23525001_2 - 0.51 9.2 28.3 3.7 6.4 12.9 2.2 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 HGTP_anticodon PF03129.18 001048076.2_23525001_2 - 0.57 10.3 7.2 3.8 7.6 0.1 3.3 3 0 0 3 3 3 0 Anticodon binding domain DUF4266 PF14086.4 001048076.2_23525001_2 - 1 10.2 2.4 1.4 9.8 0.3 2.4 2 0 0 2 2 1 0 Domain of unknown function (DUF4266) Baculo_PEP_C PF04513.10 001048076.2_23525001_2 - 1.1 9.2 16.7 1.3 8.9 2.0 4.0 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus bZIP_1 PF00170.19 001048076.2_23525001_2 - 1.2 9.2 28.1 6.1 6.9 1.4 5.7 4 1 1 5 5 5 0 bZIP transcription factor Trimer_CC PF08954.9 001048076.2_23525001_2 - 1.2 8.6 8.5 17 4.9 1.3 3.6 3 0 0 3 3 3 0 Trimerisation motif HALZ PF02183.16 001048076.2_23525001_2 - 1.3 9.1 30.6 0.17 12.0 2.2 6.1 6 1 0 6 6 5 0 Homeobox associated leucine zipper DUF3584 PF12128.6 001048076.2_23525001_2 - 1.5 6.1 40.4 3.8 4.8 40.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DUF573 PF04504.12 001048076.2_23525001_2 - 1.6 9.3 9.8 3.1 8.4 0.7 3.4 2 2 1 3 3 3 0 Protein of unknown function, DUF573 GAS PF13851.4 001048076.2_23525001_2 - 2.3 7.4 46.6 0.17 11.1 14.0 3.6 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding HOOK PF05622.10 001048076.2_23525001_2 - 2.4 6.0 44.7 3.6 5.5 42.5 1.7 1 1 1 2 2 2 0 HOOK protein DUF1759 PF03564.13 001048076.2_23525001_2 - 2.5 7.9 14.2 1.6 8.5 0.6 3.4 1 1 0 3 3 3 0 Protein of unknown function (DUF1759) APG6 PF04111.10 001048076.2_23525001_2 - 3.4 6.8 42.6 1.7 7.8 15.5 2.7 1 1 0 2 2 2 0 Autophagy protein Apg6 DUF5082 PF16888.3 001048076.2_23525001_2 - 5.1 7.3 26.6 1.1 9.4 9.4 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) DegT_DnrJ_EryC1 PF01041.15 001048076.2_23525001_2 - 5.8 6.0 7.0 0.91 8.6 2.8 1.8 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family HMMR_N PF15905.3 001048076.2_23525001_2 - 6 6.1 40.2 3.1 7.0 20.4 2.7 1 1 2 3 3 2 0 Hyaluronan mediated motility receptor N-terminal Spc7 PF08317.9 001048076.2_23525001_2 - 6.2 5.5 43.5 2.2 6.9 18.7 2.6 1 1 2 3 3 3 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.7 001048076.2_23525001_2 - 7.5 6.4 43.3 0.15 12.0 8.8 3.4 1 1 0 2 2 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3585 PF12130.6 001316730.1_16129001_2 - 2.8e-38 131.0 18.6 8.2e-38 129.5 18.6 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3585) CH PF00307.29 001316730.1_16129001_2 - 3.1e-21 75.5 0.2 1.4e-20 73.4 0.0 2.2 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001316730.1_16129001_2 - 1.1e-09 37.9 0.0 3e-09 36.4 0.0 1.9 1 0 0 1 1 1 1 CAMSAP CH domain LIM PF00412.20 001316730.1_16129001_2 - 2.3e-08 34.0 6.8 5e-08 32.9 6.8 1.6 1 0 0 1 1 1 1 LIM domain FAD_binding_3 PF01494.17 001316730.1_16129001_2 - 6.3e-05 22.3 0.0 0.00011 21.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.12 001316730.1_16129001_2 - 0.00027 20.1 0.0 0.00053 19.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001316730.1_16129001_2 - 0.00031 19.9 0.0 0.00075 18.7 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase CH_2 PF06294.9 001316730.1_16129001_2 - 0.0026 17.7 0.2 0.77 9.8 0.0 3.3 3 0 0 3 3 3 1 CH-like domain in sperm protein FAD_binding_2 PF00890.22 001316730.1_16129001_2 - 0.004 16.2 0.1 0.0071 15.3 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.12 001316730.1_16129001_2 - 0.0041 15.7 0.0 0.0075 14.9 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.22 001316730.1_16129001_2 - 0.0049 16.4 0.1 0.026 14.0 0.0 2.1 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.4 001316730.1_16129001_2 - 0.011 15.8 0.1 0.023 14.8 0.1 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.4 001316730.1_16129001_2 - 0.053 13.8 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox PF00070.25 001316730.1_16129001_2 - 0.076 13.5 0.0 0.26 11.7 0.0 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.19 001316730.1_16129001_2 - 0.083 12.0 0.0 0.17 11.0 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.15 001316730.1_16129001_2 - 0.14 11.3 0.0 0.27 10.3 0.0 1.4 1 0 0 1 1 1 0 Thi4 family DUF1967 PF09269.9 001316730.1_16129001_2 - 0.15 11.9 0.8 0.39 10.6 0.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1967) zf-RRN7 PF11781.6 001316730.1_16129001_2 - 0.21 11.2 3.1 0.57 9.8 3.1 1.8 1 0 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DASH_Hsk3 PF08227.9 001144803.1_16126001_1 - 1.8e-11 44.1 0.1 3.7e-11 43.1 0.1 1.5 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like CC2-LZ PF16516.3 001144803.1_16126001_1 - 0.2 11.9 7.5 0.086 13.0 0.6 2.6 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Peptidase_M14 PF00246.22 001024445.2_16128001_1 - 1.5e-12 47.8 0.0 3.1e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.12 001024445.2_16128001_1 - 0.00099 18.1 0.0 0.0015 17.5 0.0 1.2 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family p450 PF00067.20 001077548.1_16125001_2 - 3.5e-109 365.5 0.1 4.4e-109 365.2 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 Med15 PF09606.8 213073.2_16126001_1 - 2.9e-248 826.5 247.9 1.3e-173 579.6 74.2 2.1 1 1 1 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal Pkinase_Tyr PF07714.15 194424.1_16129001_3 - 7.6e-92 307.1 0.0 1.6e-91 306.1 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Recep_L_domain PF01030.22 194424.1_16129001_3 - 2.7e-54 181.9 1.4 2.4e-26 91.9 0.0 2.4 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.4 194424.1_16129001_3 - 7.3e-51 171.3 82.1 1.3e-46 157.5 33.4 4.2 2 1 2 4 4 4 3 Growth factor receptor domain IV Pkinase PF00069.23 194424.1_16129001_3 - 1.5e-41 142.3 0.0 2.3e-41 141.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.18 194424.1_16129001_3 - 3.5e-34 117.7 89.9 2.2e-29 102.1 37.4 4.3 2 1 2 4 4 4 3 Furin-like cysteine rich region Kinase-like PF14531.4 194424.1_16129001_3 - 0.025 13.7 0.0 0.048 12.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.21 194424.1_16129001_3 - 0.067 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3945 PF13101.4 194424.1_16129001_3 - 0.16 11.6 0.1 0.96 9.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3945) SH3_2 PF07653.15 213538.1_16126001_3 - 5.8e-21 73.8 0.0 2.6e-10 39.7 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH2 PF00017.22 213538.1_16126001_3 - 8.7e-21 73.7 0.0 1.4e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 213538.1_16126001_3 - 4.7e-20 70.8 0.1 2.6e-15 55.6 0.1 2.4 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.4 213538.1_16126001_3 - 2.6e-15 55.9 0.0 1.8e-09 37.2 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain Pkinase_Tyr PF07714.15 001005320.1_16128001_1 - 6.7e-81 271.2 0.0 9.5e-81 270.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 001005320.1_16128001_1 - 3.5e-54 181.6 1.2 3.5e-27 94.6 0.1 2.4 2 0 0 2 2 2 2 Receptor L domain Pkinase PF00069.23 001005320.1_16128001_1 - 7.1e-34 117.2 0.0 1.1e-33 116.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.18 001005320.1_16128001_1 - 5.2e-31 107.4 50.0 2.6e-30 105.1 35.0 2.5 2 1 0 2 2 2 2 Furin-like cysteine rich region GF_recep_IV PF14843.4 001005320.1_16128001_1 - 6.3e-23 80.9 52.1 1e-16 60.8 2.6 3.7 2 1 1 3 3 3 3 Growth factor receptor domain IV Kinase-like PF14531.4 001005320.1_16128001_1 - 0.032 13.4 0.0 0.069 12.3 0.0 1.5 1 0 0 1 1 1 0 Kinase-like GF_recep_IV PF14843.4 001005320.1_16128001_2 - 5.8e-12 45.4 1.4 5.8e-12 45.4 1.4 2.1 2 0 0 2 2 2 1 Growth factor receptor domain IV TGF_beta PF00019.18 001171589.1_16123001_1 - 1.6e-27 96.3 1.0 6.3e-27 94.4 0.1 2.2 2 0 0 2 2 2 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 001171589.1_16123001_1 - 0.0014 18.3 0.6 0.0025 17.5 0.1 1.7 2 0 0 2 2 2 1 TGF-beta propeptide FLYWCH PF04500.14 001171589.1_16123001_1 - 0.11 12.5 0.9 15 5.6 0.2 3.0 3 0 0 3 3 3 0 FLYWCH zinc finger domain MARCKS PF02063.15 001015060.2_16126001_2 - 1.2e-32 114.0 89.4 1.6e-32 113.5 89.4 1.1 1 0 0 1 1 1 1 MARCKS family SelR PF01641.16 212921.2_16126001_3 - 2.1e-47 160.0 0.1 3e-47 159.5 0.1 1.3 1 0 0 1 1 1 1 SelR domain TF_AP-2 PF03299.12 205094.1_23524001_2 - 2.3e-86 288.7 0.0 3.2e-86 288.2 0.0 1.2 1 0 0 1 1 1 1 Transcription factor AP-2 Myosin_head PF00063.19 001112733.1_16129001_1 - 2.2e-290 964.6 2.8 2.2e-290 964.6 2.8 3.4 3 0 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 001112733.1_16129001_1 - 7.8e-167 557.0 273.7 9.6e-167 556.7 273.7 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 001112733.1_16129001_1 - 1.5e-16 59.8 5.3 3.7e-16 58.5 5.3 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 001112733.1_16129001_1 - 0.00031 20.1 78.5 0.088 12.1 3.6 9.3 1 1 8 11 11 11 8 Reovirus sigma C capsid protein Filament PF00038.19 001112733.1_16129001_1 - 0.0034 16.9 16.8 0.0034 16.9 16.8 9.3 1 1 7 8 8 8 4 Intermediate filament protein HET-s_218-289 PF11558.6 001112733.1_16129001_1 - 0.058 13.3 0.0 0.26 11.2 0.0 2.2 1 0 0 1 1 1 0 Het-s 218-289 AAA_22 PF13401.4 001112733.1_16129001_1 - 0.1 12.7 0.1 0.1 12.7 0.1 6.6 5 3 2 7 7 7 0 AAA domain DUF1664 PF07889.10 001112733.1_16129001_1 - 0.29 11.0 156.0 0.25 11.2 6.6 13.9 1 1 15 16 16 16 0 Protein of unknown function (DUF1664) YqjK PF13997.4 001112733.1_16129001_1 - 2.5 8.2 4.9 8.7 6.5 0.1 3.9 3 0 0 3 3 3 0 YqjK-like protein ERM PF00769.17 001112733.1_16129001_1 - 5.1 6.7 289.3 0.041 13.6 34.7 9.4 1 1 6 8 8 8 0 Ezrin/radixin/moesin family zf-U1 PF06220.10 001112733.1_16129001_3 - 0.028 14.0 0.1 0.059 13.0 0.1 1.5 1 0 0 1 1 1 0 U1 zinc finger TSC22 PF01166.16 200569.2_16124001_1 - 4.9e-27 93.9 4.7 7.7e-27 93.2 4.7 1.3 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF972 PF06156.11 200569.2_16124001_1 - 0.0029 18.1 2.3 0.0049 17.3 2.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF972) ZapB PF06005.10 200569.2_16124001_1 - 0.0065 16.8 5.5 0.011 16.0 5.5 1.3 1 0 0 1 1 1 1 Cell division protein ZapB DivIC PF04977.13 200569.2_16124001_1 - 0.0072 15.9 3.8 0.015 14.9 3.8 1.5 1 0 0 1 1 1 1 Septum formation initiator K-box PF01486.15 200569.2_16124001_1 - 0.017 15.2 1.9 0.03 14.4 1.9 1.3 1 0 0 1 1 1 0 K-box region Fzo_mitofusin PF04799.11 200569.2_16124001_1 - 0.2 11.0 1.1 0.35 10.2 1.1 1.3 1 0 0 1 1 1 0 fzo-like conserved region bZIP_2 PF07716.13 200569.2_16124001_1 - 2.3 8.2 6.4 4.4 7.3 6.4 1.4 1 0 0 1 1 1 0 Basic region leucine zipper zf-C4 PF00105.16 201067.1_16129001_2 - 2.1e-30 104.8 12.0 2.1e-30 104.8 12.0 2.7 3 0 0 3 3 3 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 201067.1_16129001_2 - 1.6e-22 80.0 3.6 3.6e-22 78.8 3.6 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor PAS_3 PF08447.10 001308559.1_16125001_1 - 4.9e-21 74.7 0.0 4.2e-16 58.9 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 001308559.1_16125001_1 - 1.2e-20 73.6 1.9 2e-15 56.8 0.2 3.0 3 0 0 3 3 3 2 PAS domain HIF-1a_CTAD PF08778.8 001308559.1_16125001_1 - 4.3e-17 61.3 0.9 2.3e-16 59.0 1.1 2.1 2 0 0 2 2 2 1 HIF-1 alpha C terminal transactivation domain PAS PF00989.23 001308559.1_16125001_1 - 3.2e-15 56.0 0.0 2.9e-06 27.1 0.0 2.6 2 0 0 2 2 2 2 PAS fold HIF-1 PF11413.6 001308559.1_16125001_1 - 5.3e-15 54.4 0.1 1.6e-14 52.8 0.1 1.8 1 0 0 1 1 1 1 Hypoxia-inducible factor-1 PAS_9 PF13426.5 001308559.1_16125001_1 - 7.3e-08 32.5 0.1 0.016 15.3 0.0 3.1 2 1 1 3 3 3 2 PAS domain PAS_4 PF08448.8 001308559.1_16125001_1 - 2.4e-07 30.9 0.0 0.00076 19.6 0.0 2.6 2 0 0 2 2 2 2 PAS fold WASH-7_C PF14746.4 001308559.1_16125001_1 - 0.081 12.5 0.8 0.16 11.5 0.8 1.4 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal p450 PF00067.20 212673.1_16124001_2 - 1.4e-104 350.3 0.0 1.6e-104 350.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Kelch_6 PF13964.4 212673.1_16124001_2 - 0.023 14.9 0.1 0.63 10.3 0.0 2.4 2 0 0 2 2 2 0 Kelch motif Homeobox PF00046.27 131349.1_16122001_3 - 3.9e-23 80.9 0.6 7e-23 80.1 0.6 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 131349.1_16122001_3 - 0.00079 19.1 0.4 0.0046 16.7 0.1 2.1 2 0 0 2 2 2 1 Homeobox KN domain SIX1_SD PF16878.3 131363.1_16124001_1 - 7.5e-46 155.1 0.1 2.3e-45 153.5 0.0 1.8 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeobox PF00046.27 131363.1_16124001_1 - 5.8e-12 45.1 1.7 8e-12 44.7 0.5 1.9 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.9 131363.1_16124001_1 - 3.7e-10 39.4 0.8 7.5e-10 38.4 0.8 1.5 1 0 0 1 1 1 1 Homeobox KN domain HTH_3 PF01381.20 131363.1_16124001_1 - 0.078 12.9 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix zf-C2H2 PF00096.24 001008581.1_16127001_1 - 3.5e-24 83.7 32.9 2.3e-05 24.5 1.4 6.1 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001008581.1_16127001_1 - 1e-16 60.0 37.0 0.0003 21.2 1.3 6.7 6 0 0 6 6 6 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001008581.1_16127001_1 - 5.6e-15 54.9 31.4 4.2e-07 30.0 0.5 5.8 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_6 PF13912.4 001008581.1_16127001_1 - 8.4e-09 35.0 27.8 0.0048 16.7 4.0 5.7 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001008581.1_16127001_1 - 5.2e-08 32.9 26.6 0.008 16.3 0.1 6.2 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 001008581.1_16127001_1 - 0.00039 20.5 20.2 0.031 14.4 3.0 4.0 4 0 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 001008581.1_16127001_1 - 0.03 14.6 36.1 0.32 11.3 0.7 7.0 8 0 0 8 8 8 0 Zinc-finger of C2H2 type zf-BED PF02892.13 001008581.1_16127001_1 - 0.23 11.4 27.1 2.2 8.3 0.3 5.9 2 1 2 5 5 5 0 BED zinc finger Ogr_Delta PF04606.10 001008581.1_16127001_1 - 0.38 10.6 6.4 0.29 11.0 3.7 2.3 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Zn-ribbon_8 PF09723.8 001008581.1_16127001_1 - 9.9 6.2 18.8 1.2 9.2 0.5 3.7 3 1 1 4 4 4 0 Zinc ribbon domain p450 PF00067.20 001077458.1_16124001_2 - 5.4e-121 404.4 0.0 6.3e-121 404.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PH PF00169.27 001031180.1_23528001_2 - 2.1e-17 63.4 1.1 4.5e-17 62.3 1.1 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 001031180.1_23528001_2 - 0.00037 20.7 4.7 0.009 16.3 4.7 2.8 1 1 0 1 1 1 1 Pleckstrin homology domain EF-hand_6 PF13405.4 001031180.1_23528001_2 - 0.018 14.8 0.0 0.061 13.2 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.4 001031180.1_23528001_2 - 0.06 12.8 0.0 0.16 11.4 0.0 1.8 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.4 001031180.1_23528001_2 - 0.094 13.1 0.5 0.51 10.7 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.30 001031180.1_23528001_2 - 0.16 11.5 0.0 0.43 10.1 0.0 1.8 1 0 0 1 1 1 0 EF hand Myb_DNA-bind_2 PF08914.9 204468.1_23525001_2 - 2.2e-27 94.9 0.0 3.8e-27 94.1 0.0 1.4 1 0 0 1 1 1 1 Rap1 Myb domain Rap1_C PF11626.6 204468.1_23525001_2 - 1.9e-10 40.5 0.2 6.7e-10 38.8 0.0 2.0 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain BRCT_2 PF16589.3 204468.1_23525001_2 - 7.1e-10 39.0 0.0 1.5e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain LRR_8 PF13855.4 001031295.1_23525001_1 - 9.8e-49 162.8 59.7 3.5e-12 45.8 8.9 8.5 5 2 2 8 8 8 7 Leucine rich repeat LRR_4 PF12799.5 001031295.1_23525001_1 - 1.8e-43 145.5 65.7 2.8e-08 33.8 1.8 11.7 6 4 7 13 13 13 12 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001031295.1_23525001_1 - 1.9e-07 30.6 30.2 0.011 15.1 2.6 5.6 2 2 4 6 6 6 6 Leucine-rich repeat LRR_1 PF00560.31 001031295.1_23525001_1 - 7.9e-07 28.5 49.9 0.38 11.3 0.2 15.0 16 2 0 16 16 16 4 Leucine Rich Repeat LRR_6 PF13516.4 001031295.1_23525001_1 - 0.14 12.1 53.8 0.94 9.6 0.5 13.0 15 0 0 15 15 15 0 Leucine Rich repeat Churchill PF06573.9 204709.1_23521001_2 - 7.9e-54 180.6 0.4 9.3e-54 180.4 0.4 1.1 1 0 0 1 1 1 1 Churchill protein Nic96 PF04097.12 130981.2_16126001_1 - 1.8e-195 650.9 0.2 2.4e-195 650.5 0.2 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Nup84_Nup100 PF04121.11 130981.2_16126001_1 - 0.057 11.5 0.1 0.1 10.6 0.1 1.3 1 0 0 1 1 1 0 Nuclear pore protein 84 / 107 TPR_14 PF13428.4 130981.2_16126001_1 - 0.095 13.4 0.6 29 5.7 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat 7TMR-HDED PF07697.9 130981.2_16126001_1 - 0.38 10.7 3.9 0.2 11.6 0.4 2.2 2 1 0 2 2 2 0 7TM-HD extracellular ANAPC3 PF12895.5 130981.2_16126001_1 - 0.43 10.7 2.2 4.8 7.3 0.3 3.4 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 bZIP_1 PF00170.19 001020673.1_16124001_3 - 1.4e-11 44.2 11.5 2.9e-11 43.2 11.5 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001020673.1_16124001_3 - 1e-08 35.0 5.7 2.6e-08 33.7 5.7 1.7 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 001020673.1_16124001_3 - 0.0012 19.2 7.5 0.0026 18.1 7.5 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor GIT_CC PF16559.3 001020673.1_16124001_3 - 0.1 12.6 1.6 0.29 11.1 1.6 1.7 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Polyketide_cyc2 PF10604.7 001020673.1_16124001_3 - 0.16 12.1 0.0 0.95 9.6 0.0 2.0 2 0 0 2 2 2 0 Polyketide cyclase / dehydrase and lipid transport CTU2 PF10288.7 001003560.1_16124001_2 - 2.1e-19 69.6 7.0 2.1e-19 69.6 7.0 1.9 2 0 0 2 2 2 1 Cytoplasmic tRNA 2-thiolation protein 2 ATP_bind_3 PF01171.18 001003560.1_16124001_2 - 0.057 13.0 0.2 11 5.6 0.1 2.3 2 0 0 2 2 2 0 PP-loop family Pkinase PF00069.23 204506.2_23526001_3 - 8.7e-37 126.8 0.0 2.2e-36 125.4 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 204506.2_23526001_3 - 6.2e-36 123.9 0.0 1.1e-35 123.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 204506.2_23526001_3 - 0.00011 21.5 0.0 0.00022 20.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 204506.2_23526001_3 - 0.0015 17.8 0.4 0.0039 16.4 0.1 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 204506.2_23526001_3 - 0.16 11.7 2.6 0.32 10.7 0.0 2.5 3 0 0 3 3 3 0 Phosphotransferase enzyme family Pkinase PF00069.23 131407.1_16124001_3 - 3.8e-68 229.6 0.0 4.8e-68 229.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 131407.1_16124001_3 - 9.1e-29 100.4 0.1 1.4e-28 99.8 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 131407.1_16124001_3 - 0.0013 17.9 0.0 0.0022 17.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 131407.1_16124001_3 - 0.0025 17.6 0.0 0.0096 15.7 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.12 131407.1_16124001_3 - 0.0045 16.2 0.1 0.0074 15.5 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family HSP70 PF00012.18 001006147.1_23527001_3 - 2.9e-268 890.9 10.4 3.4e-268 890.7 10.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 001006147.1_23527001_3 - 3.8e-16 58.7 1.1 8.6e-14 50.9 0.2 2.5 2 1 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.14 001006147.1_23527001_3 - 2.3e-05 24.1 0.1 5.9e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.4 001006147.1_23527001_3 - 0.04 14.2 3.1 15 6.0 0.0 3.7 3 1 0 3 3 3 0 Cell division protein FtsA LSM PF01423.20 201004.1_16122001_2 - 1.8e-16 59.4 0.3 2.7e-16 58.9 0.3 1.3 1 0 0 1 1 1 1 LSM domain Hfq PF17209.1 201004.1_16122001_2 - 0.039 13.4 0.0 0.078 12.5 0.0 1.5 1 0 0 1 1 1 0 Hfq protein UQ_con PF00179.24 001031018.1_23529001_1 - 2.1e-16 59.7 0.0 3.2e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme eIF3_subunit PF08597.8 201214.1_16124001_2 - 6.7e-66 222.5 31.9 9.9e-66 222.0 31.9 1.2 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit CDC45 PF02724.12 201214.1_16124001_2 - 5.2 5.1 19.5 7.5 4.6 19.5 1.1 1 0 0 1 1 1 0 CDC45-like protein ABA_GPCR PF12430.6 001030791.1_23529001_3 - 5.5e-41 140.2 12.5 5.5e-41 140.2 12.5 2.0 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.6 001030791.1_23529001_3 - 3.5e-28 97.4 0.1 8.1e-28 96.2 0.1 1.7 1 0 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal LIP1 PF15904.3 001012918.1_23529001_2 - 1.1e-41 141.0 2.7 2.5e-41 139.8 2.7 1.7 1 0 0 1 1 1 1 LKB1 serine/threonine kinase interacting protein 1 LRR_8 PF13855.4 001012918.1_23529001_2 - 1.1e-09 37.8 21.4 4.1e-05 23.1 6.9 4.1 3 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.5 001012918.1_23529001_2 - 1.5e-09 37.8 21.7 2.6e-05 24.3 0.9 5.5 2 2 5 7 7 7 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001012918.1_23529001_2 - 2.4e-06 27.1 1.9 5.7e-06 25.8 1.9 1.6 1 0 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.31 001012918.1_23529001_2 - 0.49 10.9 15.7 73 4.3 0.5 6.9 6 1 0 6 6 6 0 Leucine Rich Repeat Pkinase PF00069.23 205095.1_23524001_2 - 9.9e-64 215.1 0.0 1.2e-63 214.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 205095.1_23524001_2 - 3.7e-29 101.7 0.1 5.2e-29 101.2 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 205095.1_23524001_2 - 2.4e-06 26.9 0.3 3.9e-06 26.2 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 205095.1_23524001_2 - 0.00057 19.7 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.20 205095.1_23524001_2 - 0.00071 19.1 0.2 0.0012 18.3 0.2 1.3 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.4 205095.1_23524001_2 - 0.00092 18.5 0.0 0.0014 17.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like TCTP PF00838.15 198140.1_16123001_2 - 2.4e-73 245.7 1.7 2.9e-73 245.5 1.7 1.1 1 0 0 1 1 1 1 Translationally controlled tumour protein Tetraspannin PF00335.18 001002186.1_16124001_2 - 7.3e-53 179.4 12.1 1.2e-52 178.7 12.1 1.3 1 0 0 1 1 1 1 Tetraspanin family DUF4834 PF16118.3 001002186.1_16124001_2 - 0.2 12.5 0.7 29 5.6 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF4613 PF15390.4 001006419.1_23526001_2 - 0 1053.8 0.6 0 1053.6 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4613) zf-LITAF-like PF10601.7 204267.1_23522001_1 - 7.6e-26 90.1 9.3 7.6e-26 90.1 9.3 2.1 2 0 0 2 2 2 1 LITAF-like zinc ribbon domain MT-A70 PF05063.12 207071.1_16124001_3 - 3.9e-61 205.8 0.0 5.3e-61 205.4 0.0 1.2 1 0 0 1 1 1 1 MT-A70 Asp PF00026.21 204878.1_23523001_2 - 2.7e-116 388.3 4.9 3.1e-116 388.1 4.9 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 204878.1_23523001_2 - 1e-16 61.6 6.8 3.1e-10 40.5 0.4 2.8 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 204878.1_23523001_2 - 3.2e-13 49.1 1.3 4.8e-13 48.5 1.3 1.3 1 0 0 1 1 1 1 A1 Propeptide TAXi_C PF14541.4 204878.1_23523001_2 - 3.1e-07 30.1 0.0 0.00029 20.5 0.0 3.0 2 1 1 3 3 3 2 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.4 204878.1_23523001_2 - 0.0031 18.0 0.0 2.9 8.5 0.0 2.9 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.4 204878.1_23523001_2 - 0.047 14.1 0.0 16 6.0 0.0 2.9 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease YchF-GTPase_C PF06071.11 001031254.2_23524001_1 - 1.1e-41 140.8 0.4 3.1e-41 139.3 0.4 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.21 001031254.2_23524001_1 - 2.9e-23 82.0 0.0 1.1e-22 80.2 0.0 2.0 3 0 0 3 3 3 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001031254.2_23524001_1 - 3.3e-07 29.8 0.0 6.2e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.19 001031254.2_23524001_1 - 0.0045 16.9 0.0 0.0095 15.8 0.0 1.5 1 0 0 1 1 1 1 TGS domain ArgK PF03308.14 001031254.2_23524001_1 - 0.0094 14.8 0.0 0.021 13.7 0.0 1.5 2 0 0 2 2 2 1 ArgK protein Roc PF08477.11 001031254.2_23524001_1 - 0.018 15.1 0.0 1.4 9.0 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase LOH1CR12 PF10158.7 001031357.1_23529001_2 - 6.9e-54 181.3 1.7 9.6e-54 180.8 1.7 1.2 1 0 0 1 1 1 1 Tumour suppressor protein RE_Bpu10I PF09549.8 001031357.1_23529001_2 - 0.12 11.8 0.2 0.19 11.1 0.2 1.1 1 0 0 1 1 1 0 Bpu10I restriction endonuclease DUF1664 PF07889.10 001031357.1_23529001_2 - 0.23 11.3 0.9 0.4 10.5 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) BBL5 PF07289.9 200299.1_16124001_3 - 2.3e-157 523.1 0.0 2.9e-157 522.8 0.0 1.1 1 0 0 1 1 1 1 Bardet-Biedl syndrome 5 protein bPH_3 PF14470.4 200299.1_16124001_3 - 0.00043 20.5 0.0 0.012 15.8 0.0 2.6 2 0 0 2 2 2 1 Bacterial PH domain Vps36_ESCRT-II PF11605.6 200299.1_16124001_3 - 0.0011 19.0 0.0 1.1 9.4 0.0 2.4 2 0 0 2 2 2 2 Vacuolar protein sorting protein 36 Vps36 Voldacs PF03517.11 200299.1_16124001_3 - 0.005 16.8 0.2 1.5 8.8 0.0 2.5 2 0 0 2 2 2 2 Regulator of volume decrease after cellular swelling P4Ha_N PF08336.9 001006155.1_23525001_1 - 2.1e-40 137.7 0.2 4.1e-40 136.8 0.2 1.5 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2OG-FeII_Oxy_3 PF13640.4 001006155.1_23525001_1 - 7.8e-16 58.6 0.1 4.7e-15 56.1 0.0 2.3 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.18 001006155.1_23525001_1 - 7.1e-06 26.3 0.0 1.6e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily AAA PF00004.27 200582.1_16124001_1 - 1.7e-30 106.0 0.0 3.3e-30 105.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 200582.1_16124001_1 - 9.8e-07 29.0 2.4 3.3e-06 27.3 0.2 2.9 3 1 1 4 4 3 1 AAA domain AAA_18 PF13238.4 200582.1_16124001_1 - 4.1e-06 27.2 0.0 9.1e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 200582.1_16124001_1 - 8.2e-06 26.2 0.0 1.6e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.4 200582.1_16124001_1 - 3.8e-05 23.6 0.0 9e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 200582.1_16124001_1 - 9.6e-05 22.4 0.0 0.00025 21.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.4 200582.1_16124001_1 - 0.00023 20.8 0.0 0.00054 19.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.4 200582.1_16124001_1 - 0.00028 20.4 0.9 0.17 11.3 0.0 2.3 1 1 1 2 2 2 2 AAA domain TsaE PF02367.15 200582.1_16124001_1 - 0.0013 18.6 0.0 0.0028 17.5 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE TIP49 PF06068.11 200582.1_16124001_1 - 0.0014 17.5 0.0 0.0029 16.5 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus RNA_helicase PF00910.20 200582.1_16124001_1 - 0.0019 18.5 0.1 0.0049 17.1 0.1 1.9 1 1 0 1 1 1 1 RNA helicase NACHT PF05729.10 200582.1_16124001_1 - 0.002 17.9 0.4 0.0073 16.1 0.4 1.9 1 1 0 1 1 1 1 NACHT domain ATPase_2 PF01637.16 200582.1_16124001_1 - 0.003 17.4 0.7 0.99 9.1 0.3 2.6 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea KAP_NTPase PF07693.12 200582.1_16124001_1 - 0.0035 16.5 0.3 1.1 8.3 0.2 2.6 1 1 1 2 2 2 1 KAP family P-loop domain Cytidylate_kin PF02224.16 200582.1_16124001_1 - 0.0042 16.7 0.1 0.011 15.4 0.1 1.8 1 1 0 1 1 1 1 Cytidylate kinase Viral_helicase1 PF01443.16 200582.1_16124001_1 - 0.0049 16.5 0.0 0.0095 15.6 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.4 200582.1_16124001_1 - 0.0058 16.8 0.0 0.024 14.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.4 200582.1_16124001_1 - 0.0084 15.7 0.0 0.0084 15.7 0.0 2.1 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.4 200582.1_16124001_1 - 0.0092 15.6 0.0 0.034 13.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.12 200582.1_16124001_1 - 0.01 15.7 0.1 0.025 14.4 0.1 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.10 200582.1_16124001_1 - 0.013 14.7 0.0 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus ATPase PF06745.11 200582.1_16124001_1 - 0.013 14.7 0.3 1.1 8.5 0.0 2.4 1 1 1 2 2 2 0 KaiC FtsK_SpoIIIE PF01580.16 200582.1_16124001_1 - 0.022 14.0 0.1 0.59 9.3 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_2 PF07724.12 200582.1_16124001_1 - 0.039 13.9 0.0 0.039 13.9 0.0 1.9 2 0 0 2 2 1 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.15 200582.1_16124001_1 - 0.046 13.3 0.0 0.16 11.6 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_19 PF13245.4 200582.1_16124001_1 - 0.054 13.7 0.0 0.2 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.19 200582.1_16124001_1 - 0.075 12.3 0.0 0.24 10.6 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI OAD_gamma PF04277.11 200582.1_16124001_2 - 0.33 11.4 3.5 0.51 10.8 3.5 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain N_BRCA1_IG PF16158.3 001030919.1_23529001_1 - 1.1e-32 112.7 0.2 1.9e-32 111.9 0.2 1.4 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene UBA_4 PF14555.4 001030919.1_23529001_1 - 8.8e-09 34.9 0.0 1.6e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain SOSSC PF15925.3 001006585.1_23523001_1 - 3.6e-22 79.5 0.9 1.8e-21 77.2 0.9 2.1 1 1 0 1 1 1 1 SOSS complex subunit C Ufm1 PF03671.12 001030827.1_23522001_2 - 4.4e-42 141.9 0.1 6e-42 141.5 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein CABIT PF12736.5 200169.2_16127001_1 - 3.7e-77 259.2 0.3 4.9e-77 258.9 0.3 1.2 1 0 0 1 1 1 1 Cell-cycle sustaining, positive selection, SAM_1 PF00536.28 200169.2_16127001_1 - 0.0022 18.3 0.2 0.0042 17.3 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-C4H2 PF10146.7 199642.1_16124001_2 - 2.7e-77 259.5 19.9 2.7e-77 259.5 19.9 2.1 2 0 0 2 2 2 1 Zinc finger-containing protein DZR PF12773.5 199642.1_16124001_2 - 0.025 14.5 1.5 0.064 13.2 1.5 1.6 1 0 0 1 1 1 0 Double zinc ribbon Sec20 PF03908.11 199642.1_16124001_2 - 0.071 12.9 4.2 0.096 12.5 0.3 2.4 1 1 1 2 2 2 0 Sec20 DUF4630 PF15443.4 199642.1_16124001_2 - 0.18 11.9 2.2 0.3 11.1 2.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4630) zf-RING_4 PF14570.4 199642.1_16124001_2 - 0.2 11.3 2.8 0.57 9.8 2.8 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Exonuc_VII_L PF02601.13 199642.1_16124001_2 - 3.9 6.8 7.9 6.7 6.1 7.9 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-C3HC4_3 PF13920.4 199642.1_16124001_2 - 9.3 6.1 14.4 0.4 10.5 4.1 3.1 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) PTPLA PF04387.12 001007828.1_23527001_1 - 7.1e-48 162.3 5.5 1.1e-47 161.8 5.5 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA TPR_19 PF14559.4 213544.1_16123001_3 - 6.3e-11 42.5 2.7 2.2e-06 28.0 0.3 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.15 213544.1_16123001_3 - 4.6e-10 38.7 10.7 0.0012 18.7 0.2 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.4 213544.1_16123001_3 - 7.5e-10 38.7 9.2 0.0038 17.8 0.1 5.2 3 2 3 6 6 6 4 Tetratricopeptide repeat NARP1 PF12569.6 213544.1_16123001_3 - 2.1e-06 26.8 4.2 0.00063 18.6 1.9 2.2 1 1 1 2 2 2 2 NMDA receptor-regulated protein 1 TPR_16 PF13432.4 213544.1_16123001_3 - 8.7e-06 26.2 5.2 0.7 10.5 0.1 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.4 213544.1_16123001_3 - 2.6e-05 24.0 3.8 0.29 11.3 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat Wzy_C_2 PF11846.6 213544.1_16123001_3 - 0.022 14.6 0.1 0.21 11.3 0.0 2.4 1 1 1 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal Alkyl_sulf_dimr PF14863.4 213544.1_16123001_3 - 0.022 15.1 4.9 0.8 10.0 0.0 2.6 2 1 1 3 3 3 0 Alkyl sulfatase dimerisation TPR_9 PF13371.4 213544.1_16123001_3 - 0.031 14.3 2.2 2.2 8.4 0.1 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.4 213544.1_16123001_3 - 0.054 14.0 3.9 82 4.0 0.1 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 213544.1_16123001_3 - 0.083 12.8 3.6 6.2 6.8 0.1 3.4 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.4 213544.1_16123001_3 - 0.14 12.4 0.9 1.5 9.1 0.1 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 213544.1_16123001_3 - 0.2 11.7 6.0 1.5 8.9 3.1 2.7 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.4 213544.1_16123001_3 - 0.32 11.3 2.0 65 4.1 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.26 213544.1_16123001_3 - 0.68 9.7 7.6 1.4 8.8 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat RMI1_N PF08585.10 001030822.1_23526001_2 - 2e-29 102.8 2.6 3.4e-26 92.2 0.0 3.4 2 1 0 2 2 2 1 RecQ mediated genome instability protein SMN PF06003.10 001030822.1_23526001_2 - 4.9e-11 42.3 0.7 3.8e-10 39.3 0.0 2.6 2 0 0 2 2 2 1 Survival motor neuron protein (SMN) TUDOR PF00567.22 001030822.1_23526001_2 - 2.2e-09 37.3 0.0 4.5e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Tudor domain UBA PF00627.29 001030822.1_23526001_2 - 9.7e-09 34.8 0.2 2.2e-08 33.7 0.2 1.7 1 0 0 1 1 1 1 UBA/TS-N domain DUF1325 PF07039.9 001030822.1_23526001_2 - 0.064 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 SGF29 tudor-like domain UBA_4 PF14555.4 001030822.1_23526001_2 - 0.15 11.8 0.7 0.31 10.7 0.1 1.8 2 0 0 2 2 2 0 UBA-like domain TMEM18 PF14770.4 001012698.1_23523001_2 - 2.3e-46 156.4 6.0 3.3e-46 155.9 6.0 1.2 1 0 0 1 1 1 1 Transmembrane protein 18 G-patch_2 PF12656.5 001007207.1_16125001_2 - 7e-21 74.0 0.2 7e-21 74.0 0.2 2.4 2 1 0 2 2 2 1 G-patch domain KOW PF00467.27 001007207.1_16125001_2 - 1.6e-12 46.8 2.5 1.3e-05 24.8 0.6 2.7 2 0 0 2 2 2 2 KOW motif G-patch PF01585.21 001007207.1_16125001_2 - 3.3e-06 26.8 1.2 7.6e-06 25.6 1.2 1.6 1 0 0 1 1 1 1 G-patch domain DUF1510 PF07423.9 001007207.1_16125001_2 - 0.044 13.1 12.7 0.012 15.0 3.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) DDHD PF02862.15 001007207.1_16125001_2 - 2.3 8.1 6.1 0.94 9.4 1.2 2.0 2 0 0 2 2 2 0 DDHD domain MIP-T3 PF10243.7 001007207.1_16125001_2 - 4 5.9 28.6 0.019 13.6 14.5 2.1 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 ANAPC5 PF12862.5 001006187.1_23525001_1 - 8.4e-29 99.4 2.6 8.4e-29 99.4 2.6 3.6 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 5 TPR_12 PF13424.4 001006187.1_23525001_1 - 1.4e-09 37.9 8.9 0.00026 21.1 0.1 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.4 001006187.1_23525001_1 - 6.8e-05 22.5 3.4 0.095 12.6 0.7 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.4 001006187.1_23525001_1 - 0.0013 18.4 6.7 0.022 14.5 2.2 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.4 001006187.1_23525001_1 - 0.0042 17.4 11.3 0.27 11.6 0.2 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.15 001006187.1_23525001_1 - 0.0086 16.0 12.8 0.77 9.9 2.2 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.4 001006187.1_23525001_1 - 0.82 9.9 5.9 25 5.3 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.12 001006187.1_23525001_1 - 2.8 8.7 7.8 1.3 9.8 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.26 001006187.1_23525001_1 - 7.6 6.4 7.9 2.3 8.0 1.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat LOH1CR12 PF10158.7 001007052.2_16123001_1 - 1.6e-47 160.7 2.0 3.2e-47 159.7 2.0 1.4 1 0 0 1 1 1 1 Tumour suppressor protein POX PF07526.9 001007052.2_16123001_1 - 0.019 15.4 12.1 0.098 13.1 0.5 2.4 2 0 0 2 2 2 0 Associated with HOX HA2 PF04408.21 001007052.2_16123001_1 - 0.76 10.0 4.8 2.1 8.6 4.8 1.7 1 0 0 1 1 1 0 Helicase associated domain (HA2) V_ATPase_I PF01496.17 001007052.2_16123001_1 - 1.2 6.8 12.4 1 7.0 0.0 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Proton_antipo_N PF00662.18 001007052.2_16123001_3 - 0.16 11.9 0.1 0.28 11.2 0.1 1.3 1 0 0 1 1 1 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus PH PF00169.27 001031302.1_23529001_3 - 1.3e-09 38.4 0.3 2.9e-09 37.2 0.3 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 001031302.1_23529001_3 - 0.036 14.3 0.1 0.077 13.3 0.1 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain TPR_1 PF00515.26 001006364.2_23526001_3 - 1.2e-14 53.2 15.4 2.3e-05 23.9 0.1 7.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.15 001006364.2_23526001_3 - 5.1e-13 47.9 25.6 0.0011 18.8 0.0 8.9 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_12 PF13424.4 001006364.2_23526001_3 - 8.3e-08 32.3 16.4 0.026 14.7 0.3 7.5 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.4 001006364.2_23526001_3 - 8.3e-06 25.5 12.4 0.00093 19.1 0.0 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.4 001006364.2_23526001_3 - 3e-05 24.3 17.4 1.9 9.0 0.0 8.5 8 2 2 10 10 10 1 Tetratricopeptide repeat TPR_14 PF13428.4 001006364.2_23526001_3 - 4.3e-05 23.8 5.2 11 7.0 0.0 7.4 7 1 1 8 8 7 0 Tetratricopeptide repeat TPR_7 PF13176.4 001006364.2_23526001_3 - 4.7e-05 23.0 3.0 0.032 14.1 0.0 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat SRP_TPR_like PF17004.3 001006364.2_23526001_3 - 5.1e-05 23.1 4.4 0.065 13.1 0.3 3.6 3 1 0 3 3 3 2 Putative TPR-like repeat TPR_10 PF13374.4 001006364.2_23526001_3 - 0.00087 19.0 3.2 0.48 10.2 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.4 001006364.2_23526001_3 - 0.00093 19.3 10.9 4.7 7.7 0.1 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat ANAPC3 PF12895.5 001006364.2_23526001_3 - 0.0062 16.6 27.3 2.8 8.1 0.5 7.5 7 2 0 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.4 001006364.2_23526001_3 - 0.023 15.3 0.0 7.4 7.2 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat BLOC1_2 PF10046.7 001006364.2_23526001_3 - 0.096 12.9 2.8 0.58 10.4 2.8 2.3 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_6 PF13174.4 001006364.2_23526001_3 - 0.099 13.2 4.8 30 5.4 0.0 5.8 8 0 0 8 8 6 0 Tetratricopeptide repeat DUF948 PF06103.9 001006364.2_23526001_3 - 0.32 11.1 1.3 1 9.5 0.6 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) TPR_11 PF13414.4 001006364.2_23526001_3 - 0.67 9.6 4.6 9.3 5.9 0.0 4.7 5 0 0 5 5 5 0 TPR repeat NUDIX PF00293.26 001031458.1_23525001_1 - 1.3e-05 25.2 0.1 0.014 15.3 0.0 3.2 3 0 0 3 3 3 2 NUDIX domain NTF2 PF02136.18 001006436.1_23523001_1 - 4.5e-30 104.5 0.6 6.7e-30 104.0 0.6 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Tetraspannin PF00335.18 205038.1_23525001_2 - 7.5e-26 91.1 4.1 1.1e-25 90.6 4.1 1.1 1 0 0 1 1 1 1 Tetraspanin family 2OG-FeII_Oxy_3 PF13640.4 001001529.1_23525001_1 - 6.1e-11 42.9 0.0 1.4e-10 41.7 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.18 001001529.1_23525001_1 - 6.1e-09 36.2 0.0 1.2e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TPR_2 PF07719.15 001001529.1_23525001_1 - 4.7e-05 23.0 13.0 0.0074 16.2 0.4 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.26 001001529.1_23525001_1 - 0.0019 17.8 5.7 0.021 14.5 0.8 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat YfiO PF13525.4 001001529.1_23525001_1 - 0.0034 17.0 6.6 0.54 9.8 0.4 3.0 3 1 0 3 3 3 2 Outer membrane lipoprotein TPR_19 PF14559.4 001001529.1_23525001_1 - 0.013 15.8 0.3 2.6 8.5 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.4 001001529.1_23525001_1 - 0.17 12.7 6.5 0.29 11.9 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.4 001001529.1_23525001_1 - 0.24 11.6 1.7 0.56 10.4 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.4 001001529.1_23525001_1 - 1.8 9.2 4.7 21 5.9 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Crystall PF00030.17 001007784.1_16122001_1 - 2e-63 210.4 3.6 6.5e-33 112.6 0.2 2.3 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 001007784.1_16122001_1 - 7.5e-06 25.7 3.4 0.00099 18.9 0.1 3.3 3 1 1 4 4 4 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 001007784.1_16122001_1 - 0.0079 16.2 2.5 0.064 13.3 0.3 2.9 3 1 0 3 3 3 1 Beta/Gamma crystallin LRR_9 PF14580.4 001030934.1_23526001_1 - 1.3e-15 57.2 3.3 1.3e-15 57.2 0.9 2.0 2 0 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.5 001030934.1_23526001_1 - 2.2e-12 46.8 17.0 2.3e-07 30.9 3.4 4.2 2 1 4 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001030934.1_23526001_1 - 1.8e-05 24.3 5.8 1.8e-05 24.3 5.8 3.5 3 1 1 4 4 4 2 Leucine rich repeat SDA1 PF05285.10 001030934.1_23526001_1 - 4.2e-05 23.0 21.7 6.1e-05 22.5 21.7 1.2 1 0 0 1 1 1 1 SDA1 LRR_6 PF13516.4 001030934.1_23526001_1 - 7.1e-05 22.4 5.9 0.066 13.2 0.2 3.9 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.31 001030934.1_23526001_1 - 0.93 10.1 16.4 3.5 8.3 0.5 6.1 7 0 0 7 7 7 0 Leucine Rich Repeat BTB PF00651.29 001013447.1_16126001_2 - 1.4e-33 115.2 0.3 3.3e-33 114.1 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain MATH PF00917.24 001013447.1_16126001_2 - 2.9e-05 24.0 0.0 2.9e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 MATH domain Mito_carr PF00153.25 001002367.1_16124001_2 - 8.5e-62 205.0 0.8 5.7e-21 74.1 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Cofilin_ADF PF00241.18 001004406.1_23523001_3 - 2.5e-29 101.9 0.9 3.7e-29 101.3 0.9 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Cadherin PF00028.15 204134.1_23527001_3 - 6e-81 266.9 1.7 2.4e-18 66.2 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.15 204134.1_23527001_3 - 1.5e-50 170.8 0.3 2.8e-50 169.9 0.3 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.3 204134.1_23527001_3 - 5.1e-07 29.6 1.2 0.61 10.0 0.0 4.7 4 0 0 4 4 4 2 Cadherin-like Cadherin_2 PF08266.10 204134.1_23527001_3 - 2.9e-05 23.7 0.0 0.84 9.4 0.0 4.3 4 0 0 4 4 4 2 Cadherin-like NCU-G1 PF15065.4 001004580.1_16124001_3 - 1.3e-119 399.3 0.2 1.6e-119 399.0 0.2 1.1 1 0 0 1 1 1 1 Lysosomal transcription factor, NCU-G1 CD34_antigen PF06365.10 001004580.1_16124001_3 - 0.0018 17.8 0.0 0.0035 16.9 0.0 1.3 1 0 0 1 1 1 1 CD34/Podocalyxin family RMI2 PF16100.3 001006174.1_23524001_3 - 4.2e-42 142.9 0.0 5.5e-42 142.5 0.0 1.2 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 eIF3_subunit PF08597.8 213502.1_16124001_2 - 2.9e-64 217.2 31.0 3.9e-64 216.7 31.0 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit SAP130_C PF16014.3 001031301.1_23528001_1 - 3.2e-227 754.5 17.8 3.2e-227 754.5 17.8 4.2 2 1 2 4 4 4 1 Histone deacetylase complex subunit SAP130 C-terminus DNA_pol3_delta PF06144.11 001031301.1_23528001_1 - 0.089 12.4 1.7 0.15 11.7 1.7 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit HSP70 PF00012.18 205003.2_23525001_1 - 6.2e-263 873.3 9.4 7.1e-263 873.1 9.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 205003.2_23525001_1 - 4.4e-17 61.8 0.3 1.2e-15 57.0 0.1 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.4 205003.2_23525001_1 - 0.00012 22.3 0.3 1.1 9.6 0.0 3.5 3 0 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.14 205003.2_23525001_1 - 0.0019 17.9 0.0 0.0053 16.4 0.0 1.7 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.18 205003.2_23525001_1 - 0.025 14.0 0.1 6.3 6.1 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DDR PF08841.8 205003.2_23525001_1 - 0.031 13.1 0.2 0.15 10.9 0.1 2.0 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Radial_spoke_3 PF06098.9 205003.2_23525001_1 - 0.21 10.7 5.6 0.42 9.7 5.6 1.4 1 0 0 1 1 1 0 Radial spoke protein 3 Ashwin PF15323.4 001030813.1_23529001_2 - 2e-83 279.7 9.4 3.7e-83 278.8 9.4 1.4 1 0 0 1 1 1 1 Developmental protein API5 PF05918.9 001006474.1_23526001_1 - 2.3e-202 673.3 0.0 2.8e-202 673.0 0.0 1.0 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) HEAT_2 PF13646.4 001006474.1_23526001_1 - 0.00027 21.1 0.2 0.0009 19.5 0.1 1.8 2 0 0 2 2 2 1 HEAT repeats MMS19_N PF14500.4 001006474.1_23526001_1 - 0.035 13.5 1.2 0.11 11.8 1.2 1.9 1 1 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II Dak2 PF02734.15 001006474.1_23526001_1 - 0.058 13.1 0.0 0.14 11.9 0.0 1.5 1 1 0 1 1 1 0 DAK2 domain Ribosomal_L27e PF01777.16 199724.1_16122001_1 - 2.4e-38 130.2 9.4 2.4e-38 130.2 9.4 2.0 3 0 0 3 3 3 1 Ribosomal L27e protein family KOW PF00467.27 199724.1_16122001_1 - 1.8e-07 30.7 0.2 4.5e-07 29.5 0.2 1.7 1 0 0 1 1 1 1 KOW motif OTU PF02338.17 001031499.1_23527001_2 - 0.00017 21.9 0.0 0.00031 21.1 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease WD40 PF00400.30 001004402.1_23527001_3 - 3.6e-41 138.3 28.2 1.6e-05 25.4 0.0 11.0 10 0 0 10 10 10 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001004402.1_23527001_3 - 2e-20 72.7 0.3 2.2e-06 27.7 0.0 7.0 5 3 3 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001004402.1_23527001_3 - 3.4e-10 40.0 0.3 0.026 14.3 0.0 5.1 2 1 3 5 5 5 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.10 001004402.1_23527001_3 - 0.0025 17.6 0.6 14 5.6 0.0 4.2 4 1 1 5 5 5 2 WD40-like Beta Propeller Repeat PQQ PF01011.19 001004402.1_23527001_3 - 0.0056 16.4 0.4 0.062 13.1 0.0 2.7 2 0 0 2 2 2 1 PQQ enzyme repeat IKI3 PF04762.10 001004402.1_23527001_3 - 0.011 13.6 0.0 0.7 7.7 0.0 2.7 2 1 1 3 3 3 0 IKI3 family BBS2_Mid PF14783.4 001004402.1_23527001_3 - 0.029 14.3 0.1 1.2 9.1 0.0 3.4 5 0 0 5 5 5 0 Ciliary BBSome complex subunit 2, middle region TCTP PF00838.15 205398.1_23522001_3 - 3.1e-80 268.2 0.6 3.6e-80 267.9 0.6 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Endotoxin_N PF03945.12 205398.1_23522001_3 - 0.037 13.6 0.0 0.059 12.9 0.0 1.2 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain HVSL PF09749.7 001003460.1_16124001_3 - 2.2e-62 210.5 0.2 3.1e-62 210.0 0.2 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein Tetraspannin PF00335.18 205037.1_23524001_1 - 1.3e-25 90.4 10.4 1.7e-25 89.9 10.4 1.1 1 0 0 1 1 1 1 Tetraspanin family Pkinase PF00069.23 204345.1_23524001_1 - 6.7e-68 228.8 0.0 8.3e-68 228.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 204345.1_23524001_1 - 6.5e-37 127.1 0.0 8.4e-37 126.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 204345.1_23524001_1 - 5.7e-06 25.7 0.0 1e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 204345.1_23524001_1 - 0.0025 17.6 0.0 0.0055 16.5 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.12 204345.1_23524001_1 - 0.017 14.4 0.0 0.041 13.1 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Baculo_VP1054 PF05789.9 204345.1_23524001_1 - 0.08 12.0 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Baculovirus VP1054 protein Paramyxo_PNT PF13825.4 204345.1_23524001_1 - 0.22 10.8 0.1 0.39 10.0 0.1 1.4 1 0 0 1 1 1 0 Paramyxovirus structural protein V/P N-terminus Pro_isomerase PF00160.19 001008475.1_23522001_2 - 5.5e-52 176.1 0.0 7.1e-52 175.7 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD CENP-P PF13096.4 001044635.1_23522001_1 - 2.8e-97 323.4 0.1 4e-97 322.9 0.1 1.2 1 0 0 1 1 1 1 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P Glyco_hydro_85 PF03644.11 001080578.2_16125001_1 - 8.3e-96 320.8 4.2 1.1e-95 320.4 4.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 Dzip-like_N PF13815.4 001037227.1_16127001_1 - 3.9e-41 139.6 0.1 3.9e-41 139.6 0.1 5.1 3 2 1 5 5 5 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal zf-C2H2 PF00096.24 001037227.1_16127001_1 - 0.045 14.1 6.9 0.02 15.2 3.2 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001037227.1_16127001_1 - 0.056 14.2 6.6 0.046 14.4 3.3 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_2 PF12756.5 001037227.1_16127001_1 - 0.99 9.6 6.4 0.3 11.3 2.3 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) IF-2B PF01008.15 001111238.1_16124001_2 - 4.8e-80 268.6 0.0 6e-80 268.3 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family LRR_6 PF13516.4 001045454.1_16123001_2 - 4.9e-13 47.9 6.2 0.015 15.2 0.0 7.1 7 0 0 7 7 7 4 Leucine Rich repeat LRR_4 PF12799.5 001045454.1_16123001_2 - 1.2e-05 25.3 0.0 15 6.1 0.3 4.6 2 2 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001045454.1_16123001_2 - 7.1 7.4 8.9 99 3.9 0.1 5.1 5 2 0 5 5 5 0 Leucine Rich Repeat DUF1180 PF06679.10 001103135.1_16123001_3 - 5e-27 95.2 0.1 7.1e-27 94.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) Mito_carr PF00153.25 001076602.1_16124001_1 - 1.3e-59 198.0 6.5 3.5e-21 74.8 0.1 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein TRAPP PF04051.14 001076602.1_16124001_1 - 0.0085 15.7 0.0 1.1 8.8 0.0 2.2 2 0 0 2 2 2 2 Transport protein particle (TRAPP) component Mito_carr PF00153.25 001045453.1_16124001_1 - 1.6e-69 229.8 3.9 9.8e-26 89.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Laps PF10169.7 001079501.1_23522001_3 - 3.2e-35 121.4 19.9 3.2e-35 121.4 19.9 2.7 2 1 0 2 2 2 1 Learning-associated protein DUF2423 PF10338.7 001079501.1_23522001_3 - 0.00038 20.5 7.7 0.00038 20.5 7.7 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF2423) Vps39_2 PF10367.7 001083554.1_16126001_2 - 2.4e-25 88.9 0.0 8.6e-25 87.2 0.0 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.7 001083554.1_16126001_2 - 2.8e-22 78.9 0.4 2.8e-22 78.9 0.4 4.2 4 1 0 4 4 4 1 Vacuolar sorting protein 39 domain 1 CNH PF00780.20 001083554.1_16126001_2 - 1.6e-16 60.6 0.2 3.7e-16 59.4 0.0 1.7 2 0 0 2 2 2 1 CNH domain Clathrin PF00637.18 001083554.1_16126001_2 - 1.5e-15 57.2 9.6 5.2e-08 32.7 4.1 2.5 2 0 0 2 2 2 2 Region in Clathrin and VPS DcpS PF05652.10 001083554.1_16126001_2 - 0.087 13.5 0.1 0.26 12.0 0.1 1.7 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme (DcpS) N-terminal TPR_1 PF00515.26 001083554.1_16126001_2 - 8.7 6.2 9.0 36 4.3 1.3 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat ST7 PF04184.10 001105672.1_23524001_1 - 0 1065.3 2.8 0 1065.1 2.8 1.0 1 0 0 1 1 1 1 ST7 protein TPR_6 PF13174.4 001105672.1_23524001_1 - 0.00056 20.2 0.0 0.0025 18.2 0.0 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 001105672.1_23524001_1 - 0.017 15.1 1.5 4.1 7.6 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Clathrin PF00637.18 001105672.1_23524001_1 - 0.049 13.4 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_19 PF14559.4 001105672.1_23524001_1 - 0.093 13.1 3.7 0.34 11.3 0.2 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 001105672.1_23524001_1 - 0.32 10.8 2.8 28 4.6 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.4 001105672.1_23524001_1 - 6.8 7.7 7.4 59 4.7 0.1 4.8 3 2 2 5 5 5 0 Tetratricopeptide repeat Transmemb_17 PF09799.7 001098391.1_16126001_3 - 2.7e-30 105.0 12.4 6.4e-30 103.8 12.4 1.7 1 0 0 1 1 1 1 Predicted membrane protein FAM167 PF11652.6 001025550.2_16126001_3 - 2.6e-39 133.4 0.2 4.2e-39 132.8 0.2 1.3 1 0 0 1 1 1 1 FAM167 DUF4530 PF15039.4 001025550.2_16126001_3 - 0.0071 16.3 0.2 0.014 15.4 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4530) LRR_8 PF13855.4 001089516.1_16123001_2 - 1.1e-16 60.2 0.3 1.6e-09 37.3 0.1 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 001089516.1_16123001_2 - 5.4e-05 23.3 0.0 0.00025 21.2 0.0 2.2 1 1 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 001089516.1_16123001_2 - 0.00052 19.7 0.4 1.4 9.1 0.0 2.9 2 0 0 2 2 2 2 Leucine Rich repeat LRR_1 PF00560.31 001089516.1_16123001_2 - 0.0014 18.6 0.4 0.9 10.1 0.0 3.6 3 0 0 3 3 3 1 Leucine Rich Repeat MARVEL PF01284.21 001089516.1_16123001_2 - 0.0028 17.6 0.1 0.14 12.0 0.0 2.1 2 0 0 2 2 2 1 Membrane-associating domain LRRNT PF01462.16 001089516.1_16123001_2 - 0.012 15.1 6.5 0.012 15.1 6.5 2.6 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain ELM2 PF01448.22 001079727.1_23527001_1 - 2.5e-13 50.4 0.0 6e-13 49.2 0.0 1.7 1 0 0 1 1 1 1 ELM2 domain Myb_DNA-binding PF00249.29 001079727.1_23527001_1 - 1.9e-06 27.8 0.1 3.6e-05 23.7 0.0 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.3 001079727.1_23527001_1 - 0.077 12.8 2.3 0.12 12.1 0.2 2.2 2 0 0 2 2 2 0 Myb DNA-binding like Laps PF10169.7 001037107.1_16122001_1 - 1.1e-41 142.2 15.7 1.8e-41 141.6 15.7 1.3 1 0 0 1 1 1 1 Learning-associated protein DUF2423 PF10338.7 001037107.1_16122001_1 - 0.00064 19.8 8.3 0.00064 19.8 8.3 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF2423) ABC1 PF03109.14 001079731.1_23526001_3 - 4.8e-39 133.1 0.2 7.8e-39 132.4 0.2 1.3 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.23 001079731.1_23526001_3 - 2.6e-06 26.8 0.0 0.00029 20.1 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.21 001079731.1_23526001_3 - 0.00057 19.7 0.1 0.098 12.4 0.1 2.5 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kazal_1 PF00050.19 001079731.1_23526001_3 - 0.058 13.3 1.4 0.11 12.3 1.4 1.5 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain TMEM251 PF15190.4 001079732.1_23522001_1 - 3.3e-69 230.7 2.7 4.5e-69 230.2 2.7 1.2 1 0 0 1 1 1 1 Transmembrane protein 251 DUF4064 PF13273.4 001079732.1_23522001_1 - 0.0035 17.5 0.0 0.0055 16.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) AA_permease PF00324.19 001079732.1_23522001_1 - 0.059 11.8 0.2 0.084 11.3 0.2 1.1 1 0 0 1 1 1 0 Amino acid permease DUF4131 PF13567.4 001079732.1_23522001_1 - 1.2 8.6 7.1 1.2 8.6 2.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) PPTA PF01239.20 001079732.1_23522001_2 - 0.1 12.2 0.2 0.24 11.1 0.2 1.6 1 0 0 1 1 1 0 Protein prenyltransferase alpha subunit repeat Lectin_C PF00059.19 001039598.1_23522001_1 - 1.3e-18 67.6 0.0 1.9e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 001039598.1_23522001_1 - 5.5e-13 48.3 49.8 1.4e-07 31.0 23.0 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Chordopox_A33R PF05966.10 001039598.1_23522001_1 - 0.029 13.5 0.0 0.042 13.0 0.0 1.2 1 0 0 1 1 1 0 Chordopoxvirus A33R protein Draxin PF15550.4 001142848.2_23524001_1 - 2.3e-137 458.0 10.4 2.9e-137 457.7 10.4 1.1 1 0 0 1 1 1 1 Draxin AAA_29 PF13555.4 001142848.2_23524001_3 - 0.13 11.9 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad60-SLD PF11976.6 001002677.2_16123001_2 - 1.5e-24 85.5 0.1 2.4e-24 84.8 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.21 001002677.2_16123001_2 - 3.5e-10 39.3 0.1 5.3e-10 38.8 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family OCC1 PF15506.4 001161493.1_16121001_2 - 7.3e-36 122.0 3.3 9.5e-36 121.6 3.3 1.1 1 0 0 1 1 1 1 OCC1 family Rdx PF10262.7 178290.6_16123001_1 - 1.2e-11 44.5 0.0 2.2e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 Rdx family P4Ha_N PF08336.9 001198738.1_23529001_1 - 6.8e-40 136.1 0.1 1.2e-39 135.3 0.1 1.4 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2OG-FeII_Oxy_3 PF13640.4 001198738.1_23529001_1 - 1.8e-15 57.4 0.0 3.3e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Fis1_TPR_C PF14853.4 001198738.1_23529001_1 - 0.0019 18.1 0.4 0.007 16.3 0.4 1.9 1 1 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat YfiO PF13525.4 001198738.1_23529001_1 - 0.24 11.0 3.0 0.42 10.2 3.0 1.3 1 0 0 1 1 1 0 Outer membrane lipoprotein Transmemb_17 PF09799.7 001276388.1_23523001_2 - 4.4e-29 101.1 15.3 4.4e-29 101.1 15.3 1.9 2 0 0 2 2 2 1 Predicted membrane protein DUF3043 PF11241.6 001276388.1_23523001_2 - 0.24 11.3 9.9 1.4 8.8 1.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3043) Keratin PF02422.14 001277801.1_23522001_3 - 3.2e-42 142.0 8.9 4.4e-42 141.5 8.9 1.2 1 0 0 1 1 1 1 Keratin CALCOCO1 PF07888.9 001277801.1_23522001_3 - 0.25 9.7 0.1 0.33 9.3 0.1 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Ribosomal_L26 PF16906.3 001277099.1_23522001_2 - 6.2e-44 148.3 5.7 8.4e-44 147.9 5.7 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.27 001277099.1_23522001_2 - 1e-07 31.5 5.7 2.9e-07 30.1 5.7 1.9 1 1 0 1 1 1 1 KOW motif Laminin_EGF PF00053.22 204166.2_23529001_3 - 2.7e-115 376.3 268.9 7.7e-11 41.8 13.8 13.8 13 0 0 13 13 13 13 Laminin EGF domain Laminin_N PF00055.15 204166.2_23529001_3 - 7.4e-77 258.0 0.0 7.4e-77 258.0 0.0 2.9 3 0 0 3 3 3 1 Laminin N-terminal (Domain VI) F5_F8_type_C PF00754.23 204166.2_23529001_3 - 0.026 14.5 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 F5/8 type C domain Laminin_II PF06009.10 204166.2_23529001_3 - 0.056 13.3 0.2 0.056 13.3 0.2 4.9 3 1 2 5 5 5 0 Laminin Domain II APG6 PF04111.10 204166.2_23529001_3 - 0.18 11.0 0.0 0.18 11.0 0.0 4.1 3 1 0 4 4 4 0 Autophagy protein Apg6 DUF948 PF06103.9 204166.2_23529001_3 - 0.41 10.8 11.4 11 6.2 0.2 4.7 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) IpaD PF06511.9 204166.2_23529001_3 - 0.85 8.8 7.8 0.36 10.0 4.8 1.9 1 1 1 2 2 2 0 Invasion plasmid antigen IpaD DUF1635 PF07795.9 204166.2_23529001_3 - 2.4 8.0 5.0 9 6.1 4.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1635) BRE1 PF08647.9 204166.2_23529001_3 - 3 7.8 19.7 1.2 9.1 0.7 4.5 4 0 0 4 4 4 0 BRE1 E3 ubiquitin ligase LRR_9 PF14580.4 001319131.1_16124001_3 - 2.9e-16 59.3 8.0 1.6e-12 47.1 0.8 3.2 2 1 1 3 3 3 2 Leucine-rich repeat LRR_4 PF12799.5 001319131.1_16124001_3 - 8.3e-11 41.8 25.2 1.5e-05 25.1 0.1 4.3 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001319131.1_16124001_3 - 1.2e-10 40.9 12.3 5.2e-07 29.2 3.8 3.8 1 1 3 4 4 4 4 Leucine rich repeat LRR_6 PF13516.4 001319131.1_16124001_3 - 0.056 13.4 11.1 0.1 12.5 0.1 4.5 5 0 0 5 5 5 0 Leucine Rich repeat MGC-24 PF05283.9 001319131.1_16124001_3 - 4.1 7.7 5.2 2 8.8 0.1 2.5 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin CCDC23 PF15674.3 001202432.2_16123001_3 - 8e-26 89.7 15.5 1.5e-25 88.8 15.5 1.5 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 23 Sep15_SelM PF08806.9 178286.4_16122001_3 - 1.7e-20 72.8 0.0 2.7e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Sep15/SelM redox domain GTP_EFTU PF00009.25 001321516.1_23524001_2 - 2.7e-54 183.6 0.0 3.7e-54 183.1 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 001321516.1_23524001_2 - 1.1e-39 135.1 0.0 2.3e-39 134.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.23 001321516.1_23524001_2 - 8.2e-15 54.8 0.7 8.2e-15 54.8 0.7 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 001321516.1_23524001_2 - 0.00042 20.2 0.2 0.0097 15.8 0.2 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.4 001321516.1_23524001_2 - 0.0096 15.8 1.7 0.016 15.0 0.3 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 4 Dynamin_N PF00350.21 001321516.1_23524001_2 - 0.11 12.4 0.1 19 5.1 0.1 2.4 2 0 0 2 2 2 0 Dynamin family G-alpha PF00503.18 001321516.1_23524001_2 - 0.15 11.0 0.1 0.44 9.5 0.0 1.7 2 0 0 2 2 2 0 G-protein alpha subunit Globin PF00042.20 001004376.3_23522001_3 - 7e-29 100.5 0.1 9.5e-29 100.0 0.1 1.2 1 0 0 1 1 1 1 Globin Tetraspannin PF00335.18 001328582.1_16124001_3 - 6e-59 199.2 13.1 1e-58 198.5 13.1 1.3 1 0 0 1 1 1 1 Tetraspanin family UBD PF16455.3 001002718.2_16125001_3 - 1.2e-38 131.3 0.0 2e-38 130.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-binding domain ubiquitin PF00240.21 001002718.2_16125001_3 - 2.5e-13 49.4 0.0 4e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 001002718.2_16125001_3 - 5.9e-07 29.1 0.0 8.8e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UPF0061 PF02696.12 001044871.3_16127001_2 - 1.3e-124 416.5 0.0 1.8e-124 416.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Hormone_6 PF00236.16 001044871.3_16127001_2 - 0.055 13.3 0.0 0.19 11.6 0.0 1.8 2 0 0 2 2 2 0 Glycoprotein hormone RBP_receptor PF14752.4 001045312.1_16126001_3 - 8.4e-259 860.1 18.2 9.8e-259 859.9 18.2 1.0 1 0 0 1 1 1 1 Retinol binding protein receptor MIF PF01187.16 001043321.1_16122001_3 - 9.9e-47 157.8 0.0 1.2e-46 157.5 0.0 1.1 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Tautomerase PF01361.19 001043321.1_16122001_3 - 0.0017 18.1 0.0 0.079 12.8 0.0 2.2 2 0 0 2 2 2 1 Tautomerase enzyme TUDOR PF00567.22 001305104.1_23528001_3 - 8.1e-77 255.0 1.0 1e-24 86.7 0.1 3.4 3 0 0 3 3 3 3 Tudor domain OST-HTH PF12872.5 001305104.1_23528001_3 - 5.9e-19 67.6 0.1 7.1e-13 48.1 0.0 4.1 4 0 0 4 4 4 3 OST-HTH/LOTUS domain LRRFIP PF09738.7 001305104.1_23528001_3 - 0.054 12.9 0.1 0.77 9.1 0.0 2.2 2 0 0 2 2 2 0 LRRFIP family Agenet PF05641.10 001305104.1_23528001_3 - 1.1 9.7 4.2 2.5 8.5 0.1 3.4 4 0 0 4 4 4 0 Agenet domain APG12 PF04110.11 001246200.1_16121001_1 - 1.4e-36 124.6 0.0 1.7e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.14 001246200.1_16121001_1 - 6.3e-06 26.2 0.0 7.4e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like MPP6 PF10175.7 001246200.1_16121001_1 - 0.028 14.8 0.1 0.03 14.7 0.1 1.1 1 0 0 1 1 1 0 M-phase phosphoprotein 6 UQ_con PF00179.24 001002330.5_16127001_3 - 4.6e-29 100.7 0.1 7.2e-29 100.1 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.11 001002330.5_16127001_3 - 0.01 15.5 0.1 0.038 13.7 0.0 1.9 1 1 0 1 1 1 0 UEV domain RWD PF05773.20 001002330.5_16127001_3 - 0.16 12.1 0.0 2.9 8.1 0.0 2.5 2 1 0 3 3 3 0 RWD domain Acyl-CoA_dh_1 PF00441.22 201181.2_16124001_1 - 8e-43 146.1 0.6 1.7e-42 145.0 0.1 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.14 201181.2_16124001_1 - 2.1e-33 115.2 0.1 3.9e-33 114.3 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.17 201181.2_16124001_1 - 5.6e-26 90.4 0.1 1.3e-25 89.3 0.1 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.9 201181.2_16124001_1 - 2.3e-08 34.3 0.0 1.1e-07 32.0 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.4 201181.2_16124001_1 - 0.043 14.2 0.0 0.69 10.3 0.0 2.5 2 0 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal Globin PF00042.20 001004390.2_23522001_1 - 6.9e-31 106.9 0.0 1.1e-30 106.2 0.0 1.3 1 0 0 1 1 1 1 Globin Globin PF00042.20 001004375.2_23522001_1 - 3.3e-32 111.2 0.2 6.6e-32 110.2 0.1 1.5 2 0 0 2 2 2 1 Globin Med24_N PF11277.6 001004375.2_23522001_1 - 0.089 10.6 0.0 0.11 10.3 0.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal Pkinase PF00069.23 001044902.1_16124001_3 - 2.4e-50 171.2 0.0 3.2e-50 170.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001044902.1_16124001_3 - 4e-23 81.9 0.0 6.3e-23 81.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Fringe PF02434.14 001302248.1_16124001_1 - 3.4e-63 213.3 0.0 2e-55 187.9 0.0 2.4 3 0 0 3 3 3 2 Fringe-like Galactosyl_T PF01762.19 001302248.1_16124001_1 - 0.00015 21.5 0.0 5.6 6.6 0.0 3.2 2 1 1 3 3 3 3 Galactosyltransferase Glyco_transf_21 PF13506.4 001302248.1_16124001_1 - 0.0021 17.4 0.0 0.25 10.7 0.0 2.2 1 1 1 2 2 2 2 Glycosyl transferase family 21 DUF604 PF04646.10 001302248.1_16124001_1 - 0.0064 15.7 0.0 0.077 12.2 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF604 Glycos_transf_2 PF00535.24 001302248.1_16124001_1 - 0.063 13.0 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 DUF4604 PF15377.4 205725.2_16123001_1 - 0.012 15.9 13.4 0.018 15.4 13.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Lectin_leg-like PF03388.11 205725.2_16123001_2 - 2.5e-77 259.2 0.0 4.2e-77 258.4 0.0 1.3 1 1 0 1 1 1 1 Legume-like lectin family DUF4604 PF15377.4 205725.2_16123001_2 - 0.011 16.1 13.8 0.018 15.4 13.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) DUF4604 PF15377.4 205725.2_16123001_3 - 0.0011 19.4 10.3 0.0015 18.9 10.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Ribosomal_L26 PF16906.3 001277098.2_23522001_2 - 1.5e-43 147.1 5.7 2e-43 146.6 5.7 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.27 001277098.2_23522001_2 - 7.2e-08 32.0 4.4 2.1e-07 30.6 4.4 1.8 1 0 0 1 1 1 1 KOW motif GTP_EFTU PF00009.25 001017795.2_16125001_1 - 9.8e-54 181.7 0.0 1.5e-53 181.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 001017795.2_16125001_1 - 1.1e-39 135.1 0.0 2.1e-39 134.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.23 001017795.2_16125001_1 - 1.1e-13 51.2 0.5 3.1e-13 49.8 0.5 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 001017795.2_16125001_1 - 0.00079 19.4 0.2 0.014 15.3 0.2 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.4 001017795.2_16125001_1 - 0.02 14.7 1.2 0.037 13.9 0.2 1.9 2 0 0 2 2 2 0 Elongation factor Tu domain 4 PMI_typeI PF01238.19 001033110.1_16124001_2 - 6.5e-126 420.4 0.0 8.3e-126 420.0 0.0 1.1 1 0 0 1 1 1 1 Phosphomannose isomerase type I GTP_EFTU PF00009.25 001002371.1_16125001_2 - 4.1e-55 186.2 0.0 5.8e-55 185.7 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 001002371.1_16125001_2 - 4.3e-39 133.2 0.0 9.6e-39 132.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.23 001002371.1_16125001_2 - 1.6e-13 50.7 0.2 4.7e-13 49.2 0.2 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 001002371.1_16125001_2 - 0.00043 20.2 0.3 0.008 16.1 0.3 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.4 001002371.1_16125001_2 - 0.065 13.1 0.9 0.14 12.1 0.1 1.9 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Dynamin_N PF00350.21 001002371.1_16125001_2 - 0.082 12.8 0.1 16 5.4 0.0 2.5 2 0 0 2 2 2 0 Dynamin family PTPLA PF04387.12 001044984.1_16124001_2 - 5.3e-45 153.0 8.1 8.9e-45 152.3 8.1 1.4 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Cylicin_N PF15241.4 001044984.1_16124001_2 - 0.0009 19.3 0.5 0.0016 18.5 0.5 1.3 1 0 0 1 1 1 1 Cylicin N-terminus CS PF04969.14 001044984.1_16124001_2 - 0.04 14.8 0.1 0.17 12.8 0.0 2.0 2 0 0 2 2 2 0 CS domain COX4 PF02936.12 001044984.1_16124001_2 - 0.15 12.0 1.6 0.38 10.6 1.6 1.7 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV TF_AP-2 PF03299.12 001008576.2_16129001_1 - 1.2e-87 292.9 0.0 1.8e-87 292.3 0.0 1.3 1 0 0 1 1 1 1 Transcription factor AP-2 Uricase PF01014.16 001002332.1_16123001_2 - 5e-57 191.7 0.1 7.8e-33 113.5 0.0 2.3 2 0 0 2 2 2 2 Uricase FolB PF02152.16 001002332.1_16123001_2 - 0.00012 22.4 0.1 0.00022 21.6 0.1 1.4 1 0 0 1 1 1 1 Dihydroneopterin aldolase OST-HTH PF12872.5 001044850.1_16127001_1 - 2e-36 123.6 0.4 2.5e-11 43.2 0.0 3.4 3 0 0 3 3 3 3 OST-HTH/LOTUS domain TUDOR PF00567.22 001044850.1_16127001_1 - 1.5e-19 70.1 0.3 3.7e-19 68.8 0.3 1.7 1 0 0 1 1 1 1 Tudor domain ECH_1 PF00378.18 001305110.1_23523001_1 - 4e-34 117.9 0.0 5.6e-34 117.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 001305110.1_23523001_1 - 1.4e-18 67.3 0.1 1.8e-18 67.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.18 001305112.1_23522001_1 - 4.5e-21 75.2 0.0 6.2e-21 74.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 001305112.1_23522001_1 - 2.6e-06 27.0 0.1 3.3e-06 26.7 0.1 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Serpin PF00079.18 001110374.2_16128001_1 - 1.3e-90 304.2 3.5 1.6e-90 304.0 3.5 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) 7tm_1 PF00001.19 137277.1_16126120_1 - 2.1e-16 59.8 7.3 3.7e-16 59.0 7.3 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.4 137277.1_16126120_3 - 1.7e-42 142.9 25.6 3.9e-13 48.8 3.1 5.1 2 2 3 5 5 5 5 Leucine rich repeat LRR_5 PF13306.4 137277.1_16126120_3 - 1.5e-16 60.4 2.9 1e-07 31.8 0.7 2.5 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 137277.1_16126120_3 - 1.7e-15 56.7 27.3 6.4e-05 23.1 2.6 5.9 4 2 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 137277.1_16126120_3 - 6.6e-08 32.1 5.8 0.00016 21.1 0.1 3.0 1 1 3 4 4 4 3 Leucine-rich repeat Ldl_recept_a PF00057.16 137277.1_16126120_3 - 1.7e-06 28.0 5.9 1.7e-06 28.0 5.9 2.3 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A LRR_1 PF00560.31 137277.1_16126120_3 - 0.028 14.7 25.5 1.3 9.7 1.2 8.6 8 0 0 8 8 8 0 Leucine Rich Repeat LRR_6 PF13516.4 137277.1_16126120_3 - 1.4 9.0 19.3 42 4.4 0.1 7.4 8 0 0 8 8 8 0 Leucine Rich repeat DnaB_C PF03796.13 212622.2_16124001_1 - 0.11 11.7 3.5 0.16 11.1 3.5 1.2 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Cystatin PF00031.19 212622.2_16124001_3 - 2.5e-12 46.8 2.9 1.8e-11 44.0 0.0 2.4 2 0 0 2 2 2 1 Cystatin domain Cathelicidins PF00666.15 212622.2_16124001_3 - 5.2e-09 36.2 3.6 0.0018 18.4 1.3 2.4 2 0 0 2 2 2 2 Cathelicidin Spp-24 PF07448.9 212622.2_16124001_3 - 1.1 9.4 4.6 0.34 11.0 0.5 2.0 2 0 0 2 2 2 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Hist_deacetyl PF00850.17 204831.2_23524001_2 - 1.6e-83 280.6 0.1 2.4e-83 280.0 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Homeobox PF00046.27 131249.2_16125001_2 - 1.1e-20 73.1 4.6 1.9e-20 72.3 4.6 1.4 1 0 0 1 1 1 1 Homeobox domain 7tm_1 PF00001.19 131707.2_16123001_1 - 2.8e-58 197.1 25.2 4.6e-58 196.4 25.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 131707.2_16123001_1 - 2.9e-09 36.6 23.4 4.1e-09 36.1 23.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 131707.2_16123001_1 - 8.1e-06 25.6 20.2 1.6e-05 24.6 20.2 1.4 1 1 0 1 1 1 1 Olfactory receptor LRR_8 PF13855.4 001100024.1_16124001_1 - 1.4e-45 152.7 14.9 1.2e-15 56.9 2.1 5.4 3 2 3 6 6 6 5 Leucine rich repeat LRR_5 PF13306.4 001100024.1_16124001_1 - 1.7e-21 76.3 0.0 9.2e-14 51.4 0.0 2.5 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001100024.1_16124001_1 - 5.3e-21 74.2 12.1 1.2e-05 25.4 0.1 5.9 3 2 3 6 6 6 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001100024.1_16124001_1 - 1.4e-09 37.6 2.0 0.0014 18.0 0.0 3.3 1 1 2 3 3 3 2 Leucine-rich repeat I-set PF07679.14 001100024.1_16124001_1 - 2.2e-09 37.1 0.0 4.1e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_1 PF00560.31 001100024.1_16124001_1 - 7.2e-08 31.7 12.7 3.5 8.3 0.0 8.5 9 0 0 9 9 9 1 Leucine Rich Repeat Ig_3 PF13927.4 001100024.1_16124001_1 - 1.2e-07 32.1 0.0 3e-07 30.8 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 001100024.1_16124001_1 - 0.00019 21.4 0.1 0.00046 20.2 0.1 1.7 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 001100024.1_16124001_1 - 0.0011 18.9 0.0 0.0023 17.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRRNT PF01462.16 001100024.1_16124001_1 - 0.019 14.4 6.5 0.059 12.9 6.5 1.9 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain Ig_2 PF13895.4 001100024.1_16124001_1 - 0.029 14.6 0.0 0.085 13.1 0.0 1.9 1 0 0 1 1 1 0 Immunoglobulin domain LRR_6 PF13516.4 001100024.1_16124001_1 - 2.1 8.5 20.7 36 4.7 0.4 7.1 7 0 0 7 7 7 0 Leucine Rich repeat CUB PF00431.18 131010.1_16129001_1 - 5.7e-187 609.1 8.8 8.4e-41 138.6 0.1 5.3 5 0 0 5 5 5 5 CUB domain Astacin PF01400.22 131010.1_16129001_1 - 8.9e-73 243.8 0.6 1.8e-72 242.9 0.0 1.8 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) FXa_inhibition PF14670.4 131010.1_16129001_1 - 1.2e-19 70.2 25.3 5.3e-10 39.3 7.6 3.4 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 131010.1_16129001_1 - 9.5e-12 44.8 28.0 1.6e-06 28.1 6.6 3.5 2 0 0 2 2 2 2 Calcium-binding EGF domain cEGF PF12662.5 131010.1_16129001_1 - 1.9e-10 40.3 4.9 1.6e-05 24.5 0.8 3.6 2 0 0 2 2 2 2 Complement Clr-like EGF-like CUB_2 PF02408.18 131010.1_16129001_1 - 4.9e-05 23.0 3.6 0.34 10.6 0.1 4.6 5 0 0 5 5 5 2 CUB-like domain EGF_3 PF12947.5 131010.1_16129001_1 - 0.00047 20.2 13.8 0.0007 19.6 4.5 3.9 3 1 1 4 4 3 2 EGF domain Peptidase_M10 PF00413.22 131010.1_16129001_1 - 0.0064 16.2 0.1 0.95 9.2 0.0 2.4 2 0 0 2 2 2 1 Matrixin Reprolysin_4 PF13583.4 131010.1_16129001_1 - 0.034 13.6 0.0 0.071 12.6 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like hEGF PF12661.5 131010.1_16129001_1 - 0.057 14.0 25.5 0.061 13.9 3.3 4.2 3 0 0 3 3 3 0 Human growth factor-like EGF DUF3558 PF12079.6 131010.1_16129001_1 - 0.11 12.3 5.1 11 5.9 0.1 4.3 4 1 1 5 5 5 0 Protein of unknown function (DUF3558) zf-C2H2 PF00096.24 131723.1_16124001_1 - 5e-14 51.7 32.7 5e-05 23.4 4.1 5.1 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 131723.1_16124001_1 - 5.3e-10 39.1 13.6 4.2e-06 26.8 4.9 5.4 5 1 1 6 6 6 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 131723.1_16124001_1 - 3.7e-08 33.4 24.3 0.01 16.4 3.5 5.2 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.5 131723.1_16124001_1 - 0.014 15.7 9.5 0.43 10.9 1.3 3.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.3 131723.1_16124001_1 - 0.33 11.1 5.6 0.81 9.9 5.6 1.7 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.4 131723.1_16124001_1 - 0.92 9.4 9.5 0.69 9.8 2.2 3.1 2 0 0 2 2 2 0 C2H2-type zinc finger Calreticulin PF00262.16 213448.1_16129001_1 - 7.9e-166 551.3 9.8 1.1e-165 550.8 9.8 1.2 1 0 0 1 1 1 1 Calreticulin family DUF1510 PF07423.9 213448.1_16129001_1 - 3.2e-06 26.6 3.1 3.4e-05 23.3 2.7 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1510) SpoIIIAH PF12685.5 213448.1_16129001_1 - 0.00038 20.2 1.0 0.00098 18.9 0.4 1.8 2 0 0 2 2 2 1 SpoIIIAH-like protein TRAP_alpha PF03896.14 213448.1_16129001_1 - 0.0077 15.3 5.7 0.072 12.2 1.1 2.4 2 0 0 2 2 2 2 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.4 213448.1_16129001_1 - 0.052 13.1 6.0 0.6 9.6 3.3 2.8 2 1 0 2 2 2 0 FAM176 family zf-C2H2 PF00096.24 212863.2_16129001_3 - 7.8e-14 51.1 21.8 4.7e-05 23.5 0.6 4.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 212863.2_16129001_3 - 5e-10 39.2 10.3 2.1e-06 27.8 0.8 4.8 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 212863.2_16129001_3 - 5.5e-07 29.8 20.7 0.018 15.7 4.0 5.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-LYAR PF08790.9 212863.2_16129001_3 - 0.15 11.9 2.9 0.68 9.8 0.9 2.6 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-met PF12874.5 212863.2_16129001_3 - 0.2 12.0 8.7 0.34 11.2 2.6 3.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 212863.2_16129001_3 - 0.61 10.3 11.8 0.69 10.2 3.0 4.4 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding wnt PF00110.17 001079834.1_16123001_1 - 1.9e-120 401.9 21.8 2.3e-120 401.7 21.8 1.0 1 0 0 1 1 1 1 wnt family ATP-synt_ab PF00006.23 001024429.2_16124001_2 - 3.3e-64 216.3 0.0 4.6e-64 215.9 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.21 001024429.2_16124001_2 - 1.2e-23 83.2 2.1 2.3e-23 82.3 2.1 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase_2 PF01637.16 001024429.2_16124001_2 - 0.0097 15.7 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea DUF258 PF03193.14 001024429.2_16124001_2 - 0.032 14.0 0.0 0.065 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ATPase PF06745.11 001024429.2_16124001_2 - 0.039 13.2 0.1 0.063 12.5 0.1 1.3 1 0 0 1 1 1 0 KaiC NB-ARC PF00931.20 001024429.2_16124001_2 - 0.082 11.8 0.8 0.11 11.3 0.1 1.5 2 0 0 2 2 2 0 NB-ARC domain AAA PF00004.27 001024429.2_16124001_2 - 0.14 12.4 0.0 1.4 9.2 0.0 2.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.4 001024429.2_16124001_2 - 0.17 12.1 1.2 0.35 11.1 0.3 1.8 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.25 001024429.2_16124001_2 - 0.18 12.2 0.0 0.39 11.1 0.0 1.5 1 0 0 1 1 1 0 ABC transporter E1-E2_ATPase PF00122.18 200965.1_16128001_3 - 9.9e-66 221.1 1.3 9.9e-66 221.1 1.3 2.3 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 200965.1_16128001_3 - 3.9e-45 153.7 4.2 9.1e-45 152.4 4.2 1.7 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 200965.1_16128001_3 - 6.1e-20 71.0 0.7 1.1e-19 70.1 0.7 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.24 200965.1_16128001_3 - 1.4e-19 69.3 0.3 8.9e-19 66.8 0.0 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.24 200965.1_16128001_3 - 3.1e-17 63.4 0.2 7.7e-16 58.9 0.2 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 200965.1_16128001_3 - 1.6e-05 24.7 0.6 3.4e-05 23.6 0.6 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 200965.1_16128001_3 - 0.00032 21.0 0.1 0.0013 19.0 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase V-ATPase_H_N PF03224.12 001291708.1_16124001_3 - 1.5e-107 359.5 5.0 1.5e-107 359.5 5.0 1.8 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.6 001291708.1_16124001_3 - 2.1e-45 153.4 0.2 2.1e-45 153.4 0.2 2.3 3 0 0 3 3 3 1 V-ATPase subunit H Arm PF00514.21 001291708.1_16124001_3 - 1.4e-06 28.0 1.4 0.00074 19.3 0.0 4.3 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Arm_2 PF04826.11 001291708.1_16124001_3 - 0.0033 16.8 0.2 0.014 14.7 0.0 2.0 2 0 0 2 2 2 1 Armadillo-like DUF2326 PF10088.7 001291708.1_16124001_3 - 0.0039 16.8 0.1 0.012 15.2 0.1 1.8 1 0 0 1 1 1 1 Uncharacterised protein conserved in bacteria (DUF2326) SPOB_ab PF14682.4 001291708.1_16124001_3 - 0.04 13.9 2.9 0.043 13.8 0.6 2.2 2 0 0 2 2 2 0 Sporulation initiation phospho-transferase B, C-terminal IATP PF04568.10 001044859.1_16122001_1 - 8.1e-23 80.6 6.6 1.1e-22 80.2 6.6 1.2 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP DUF812 PF05667.9 001044859.1_16122001_1 - 0.0032 16.3 0.9 0.0035 16.2 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Phage_lysis PF03245.11 001044859.1_16122001_1 - 0.0066 16.4 1.8 0.01 15.8 1.8 1.2 1 0 0 1 1 1 1 Bacteriophage Rz lysis protein Cep57_MT_bd PF06657.11 001044859.1_16122001_1 - 0.027 14.8 5.8 0.04 14.2 4.7 1.7 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DivIC PF04977.13 001044859.1_16122001_1 - 0.068 12.8 3.3 0.091 12.4 2.6 1.6 1 1 0 1 1 1 0 Septum formation initiator DUF4407 PF14362.4 001044859.1_16122001_1 - 0.18 11.0 1.0 0.2 10.9 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3450 PF11932.6 001044859.1_16122001_1 - 0.2 10.8 2.3 0.27 10.3 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) XhlA PF10779.7 001044859.1_16122001_1 - 0.36 10.9 4.1 0.63 10.1 4.1 1.3 1 0 0 1 1 1 0 Haemolysin XhlA SWI-SNF_Ssr4 PF08549.8 001044859.1_16122001_1 - 3.6 6.0 6.6 4.4 5.7 6.6 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) ATP-synt_E PF05680.10 001172637.1_16121001_2 - 1.9e-17 63.3 0.1 2.5e-17 62.8 0.1 1.1 1 0 0 1 1 1 1 ATP synthase E chain Cation_ATPase_C PF00689.19 001128242.1_16129001_1 - 1.4e-45 155.1 2.8 1.4e-45 155.1 2.8 3.0 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.18 001128242.1_16129001_1 - 3e-36 124.7 14.1 7.4e-26 90.7 0.6 2.7 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase PF13246.4 001128242.1_16129001_1 - 3.2e-17 62.3 0.0 6.8e-17 61.2 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.24 001128242.1_16129001_1 - 3.1e-15 55.5 0.0 7.3e-15 54.3 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.24 001128242.1_16129001_1 - 6e-15 56.0 0.2 5.1e-11 43.1 0.1 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase ATP_Ca_trans_C PF12424.6 001128242.1_16129001_1 - 1e-12 48.2 0.8 3.4e-12 46.5 0.8 1.9 1 0 0 1 1 1 1 Plasma membrane calcium transporter ATPase C terminal Hydrolase_3 PF08282.10 001128242.1_16129001_1 - 7.1e-07 29.1 1.5 6.9e-05 22.6 0.5 2.6 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase ATP_Ca_trans_C PF12424.6 001128242.1_16129001_2 - 1.2e-09 38.4 0.1 3e-09 37.1 0.1 1.7 1 0 0 1 1 1 1 Plasma membrane calcium transporter ATPase C terminal PAM2 PF07145.13 001128242.1_16129001_2 - 0.04 13.5 0.2 0.15 11.7 0.2 2.1 1 0 0 1 1 1 0 Ataxin-2 C-terminal region SET PF00856.26 001039636.1_16123001_1 - 2.6e-13 50.5 0.1 8.4e-13 48.9 0.0 1.9 2 0 0 2 2 2 1 SET domain zf-MYND PF01753.16 001039636.1_16123001_1 - 4.2e-09 36.2 17.1 4.2e-09 36.2 17.1 2.2 3 0 0 3 3 3 1 MYND finger Hormone_2 PF00123.18 001190165.3_23523001_3 - 1.3e-44 149.7 4.1 2.4e-14 52.9 0.4 3.4 3 0 0 3 3 3 3 Peptide hormone Lipoprotein_10 PF03202.11 001190165.3_23523001_3 - 0.0012 19.1 2.2 5.7 7.3 0.0 3.5 3 1 1 4 4 4 2 Putative mycoplasma lipoprotein, C-terminal region zf-H2C2_2 PF13465.4 001128729.1_16123001_2 - 2.3e-12 46.6 13.0 2.9e-07 30.5 4.1 4.9 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.24 001128729.1_16123001_2 - 2.4e-11 43.3 27.6 0.00023 21.3 5.8 4.1 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001128729.1_16123001_2 - 3.2e-07 30.5 22.7 0.016 15.9 3.8 4.1 3 0 0 3 3 3 3 C2H2-type zinc finger FOXP-CC PF16159.3 001128729.1_16123001_2 - 0.0029 18.1 0.5 0.0029 18.1 0.5 3.3 2 1 1 3 3 3 1 FOXP coiled-coil domain IBR PF01485.19 001128729.1_16123001_2 - 0.24 11.5 7.8 2.4 8.3 7.8 2.5 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain YliH PF10799.6 001128729.1_16123001_3 - 0.034 13.9 0.0 0.06 13.1 0.0 1.3 1 0 0 1 1 1 0 Biofilm formation protein (YliH/bssR) Bradykinin PF06753.10 001128729.1_16123001_3 - 0.4 10.3 2.5 0.92 9.2 2.5 1.6 1 0 0 1 1 1 0 Bradykinin p450 PF00067.20 001311791.1_16124001_2 - 3.8e-102 342.3 0.0 4.3e-102 342.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Hormone_2 PF00123.18 205260.4_23524001_3 - 4e-29 100.1 0.3 3.4e-14 52.4 0.4 3.2 3 0 0 3 3 3 2 Peptide hormone ATP-synt_C PF00137.19 173255.2_16124001_2 - 8e-36 122.1 36.2 8.4e-22 77.2 14.1 2.3 2 0 0 2 2 2 2 ATP synthase subunit C Ribosomal_L22e PF01776.15 027625.1_16122120_1 - 6.6e-37 126.1 7.9 1.1e-36 125.3 7.9 1.3 1 0 0 1 1 1 1 Ribosomal L22e protein family Ribosomal_L22e PF01776.15 027625.1_16122120_2 - 0.0014 18.9 0.0 0.0022 18.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal L22e protein family Hormone_2 PF00123.18 073182.2_23523120_1 - 1.2e-44 149.7 4.1 2.3e-14 52.9 0.4 3.4 3 0 0 3 3 3 3 Peptide hormone Lipoprotein_10 PF03202.11 073182.2_23523120_1 - 0.0012 19.2 2.1 5.7 7.3 0.0 3.5 3 1 0 3 3 3 2 Putative mycoplasma lipoprotein, C-terminal region HMG_box PF00505.17 001318451.1_23525001_1 - 1.4e-22 79.8 4.5 5e-22 78.0 4.5 2.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001318451.1_23525001_1 - 1.8e-09 37.9 1.1 1.8e-09 37.9 1.1 3.4 3 0 0 3 3 3 1 HMG-box domain MPS2 PF17060.3 001318451.1_23525001_1 - 2.5 7.1 17.4 0.12 11.5 11.6 1.6 2 0 0 2 2 2 0 Monopolar spindle protein 2 DivIVA PF05103.11 001318451.1_23525001_1 - 8.8 6.3 18.7 10 6.1 13.6 2.5 2 0 0 2 2 2 0 DivIVA protein Ric8 PF10165.7 001031174.1_23526001_2 - 5e-138 460.8 2.5 8.2e-138 460.1 0.9 1.8 2 0 0 2 2 2 1 Guanine nucleotide exchange factor synembryn DUF1232 PF06803.10 001177737.1_23523001_1 - 1.2e-08 34.5 9.3 1.2e-08 34.5 9.3 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1232) zf-RING_UBOX PF13445.4 001177737.1_23523001_1 - 1.7e-08 34.2 6.0 2.9e-08 33.4 3.1 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 001177737.1_23523001_1 - 2.5e-08 33.5 2.8 5.2e-08 32.5 2.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001177737.1_23523001_1 - 2.5e-08 33.5 4.1 5.3e-08 32.5 4.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001177737.1_23523001_1 - 1.5e-07 31.3 4.3 1.5e-07 31.3 4.3 2.2 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 001177737.1_23523001_1 - 1.7e-06 28.0 7.0 3.4e-06 27.1 7.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001177737.1_23523001_1 - 1.7e-06 27.6 4.4 4.3e-06 26.3 4.4 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001177737.1_23523001_1 - 1.3e-05 24.9 4.7 3.3e-05 23.6 4.7 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.4 001177737.1_23523001_1 - 1.9e-05 24.3 4.0 5.2e-05 22.9 4.0 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 Cys_rich_CPXG PF14255.4 001177737.1_23523001_1 - 0.024 14.4 0.8 6.4 6.6 0.2 2.4 2 0 0 2 2 2 0 Cysteine-rich CPXCG zf-rbx1 PF12678.5 001177737.1_23523001_1 - 0.36 11.0 4.6 0.99 9.6 4.6 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain DpnI PF06044.10 001177737.1_23523001_1 - 0.47 9.7 4.5 0.43 9.8 0.1 2.1 2 0 0 2 2 2 0 Dam-replacing family zf-ANAPC11 PF12861.5 001177737.1_23523001_1 - 2.9 7.9 7.7 0.16 11.9 2.3 1.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Ribosomal_L2_C PF03947.16 001277728.1_23522001_3 - 1.3e-48 164.2 3.0 2.2e-48 163.5 3.0 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.21 001277728.1_23522001_3 - 4.5e-19 68.0 0.1 1.4e-18 66.5 0.1 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain PRK PF00485.16 001160071.3_23523001_3 - 3.3e-52 176.9 0.2 4.1e-52 176.7 0.2 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CoaE PF01121.18 001160071.3_23523001_3 - 5.6e-06 26.0 0.3 1.2e-05 25.0 0.3 1.4 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.4 001160071.3_23523001_3 - 0.00014 22.2 0.1 0.00036 20.9 0.1 1.6 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.10 001160071.3_23523001_3 - 0.0023 17.1 0.0 0.0037 16.5 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Cytidylate_kin PF02224.16 001160071.3_23523001_3 - 0.061 12.9 0.1 1.5 8.4 0.0 2.2 2 0 0 2 2 2 0 Cytidylate kinase AAA_17 PF13207.4 001160071.3_23523001_3 - 0.32 11.3 4.4 2.5 8.4 4.4 2.1 1 1 0 1 1 1 0 AAA domain TPR_2 PF07719.15 199610.2_16124001_2 - 9.1e-28 94.0 3.6 0.00088 19.1 0.0 9.1 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_19 PF14559.4 199610.2_16124001_2 - 1.2e-25 89.6 4.8 1.9e-05 25.0 0.0 5.9 3 2 2 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.26 199610.2_16124001_2 - 1.9e-25 87.4 7.8 2e-05 24.1 0.0 8.5 8 1 0 8 8 8 4 Tetratricopeptide repeat DnaJ PF00226.29 199610.2_16124001_2 - 1.2e-20 73.2 2.9 1.2e-20 73.2 2.9 3.1 4 0 0 4 4 3 1 DnaJ domain TPR_8 PF13181.4 199610.2_16124001_2 - 1.1e-19 68.8 9.5 0.00062 19.6 0.0 7.1 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.4 199610.2_16124001_2 - 7.3e-17 61.6 0.2 0.0085 16.6 0.4 6.2 6 1 0 7 7 6 3 Tetratricopeptide repeat TPR_11 PF13414.4 199610.2_16124001_2 - 9.3e-17 60.3 8.1 4.9e-05 22.8 0.1 7.1 4 3 4 8 8 8 4 TPR repeat TPR_9 PF13371.4 199610.2_16124001_2 - 7.1e-15 54.8 0.1 2e-05 24.5 0.2 5.0 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.4 199610.2_16124001_2 - 1.1e-14 53.5 4.6 0.041 14.2 0.0 6.9 8 0 0 8 8 6 4 Tetratricopeptide repeat TPR_14 PF13428.4 199610.2_16124001_2 - 4.3e-14 51.9 4.5 0.36 11.6 0.0 8.4 5 3 5 10 10 8 4 Tetratricopeptide repeat TPR_12 PF13424.4 199610.2_16124001_2 - 9.2e-11 41.8 5.7 0.1 12.7 0.1 6.1 3 2 2 5 5 5 4 Tetratricopeptide repeat ANAPC3 PF12895.5 199610.2_16124001_2 - 3e-09 36.8 13.3 0.012 15.7 0.4 4.9 2 1 4 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.4 199610.2_16124001_2 - 1.5e-08 34.7 15.5 0.38 11.0 0.0 6.3 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.4 199610.2_16124001_2 - 2.4e-07 30.8 11.2 1.2 9.8 0.0 8.8 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_10 PF13374.4 199610.2_16124001_2 - 0.00025 20.7 1.2 9.2 6.2 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat Rep_3 PF01051.19 199610.2_16124001_2 - 0.00075 19.3 0.8 0.00075 19.3 0.8 2.1 2 1 0 2 2 2 1 Initiator Replication protein Alkyl_sulf_dimr PF14863.4 199610.2_16124001_2 - 0.00076 19.8 6.1 2.2 8.6 0.1 4.1 2 1 2 4 4 4 2 Alkyl sulfatase dimerisation TPR_15 PF13429.4 199610.2_16124001_2 - 0.00082 18.5 9.7 0.83 8.7 0.0 4.9 2 2 2 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.4 199610.2_16124001_2 - 0.0026 17.6 3.1 75 3.6 0.7 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat ICAT PF06384.9 199610.2_16124001_2 - 0.031 14.4 3.2 3.4 7.9 0.3 2.9 2 0 0 2 2 2 0 Beta-catenin-interacting protein ICAT ATP13 PF12921.5 199610.2_16124001_2 - 0.048 13.4 0.1 0.13 12.0 0.1 1.7 1 0 0 1 1 1 0 Mitochondrial ATPase expression TPR_4 PF07721.12 199610.2_16124001_2 - 0.082 13.5 1.7 1.1e+02 3.7 0.1 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat BTAD PF03704.15 199610.2_16124001_2 - 0.35 11.2 6.9 11 6.3 0.2 4.4 3 2 1 4 4 3 0 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.4 199610.2_16124001_2 - 0.42 10.6 7.3 3.1 7.8 0.8 4.8 4 1 1 5 5 3 0 Fis1 C-terminal tetratricopeptide repeat DUF4363 PF14276.4 199610.2_16124001_2 - 5.3 7.0 14.3 1.4 8.9 1.6 4.1 3 2 0 3 3 3 0 Domain of unknown function (DUF4363) 7tm_1 PF00001.19 001003578.2_16124001_1 - 1e-32 113.3 25.9 1.6e-32 112.7 25.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001003578.2_16124001_1 - 0.0027 17.4 13.0 0.13 11.8 13.0 2.3 1 1 0 1 1 1 1 Olfactory receptor DUF2839 PF10999.6 001003578.2_16124001_1 - 0.81 10.0 4.6 4.4 7.6 4.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2839) Pkinase PF00069.23 001017607.1_16125001_3 - 9e-80 267.7 0.0 1.2e-79 267.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001017607.1_16125001_3 - 5.5e-32 110.9 0.0 7.8e-32 110.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001017607.1_16125001_3 - 6.9e-05 22.2 0.0 0.00013 21.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001017607.1_16125001_3 - 0.0023 17.2 0.1 0.012 14.9 0.1 1.9 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 001017607.1_16125001_3 - 0.0092 15.5 0.0 3.6 7.0 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 CCT_2 PF09425.8 001017607.1_16125001_3 - 0.11 12.3 0.5 0.27 11.0 0.5 1.5 1 0 0 1 1 1 0 Divergent CCT motif Laminin_G_1 PF00054.21 001007151.3_16124001_1 - 4.6e-20 72.0 0.0 6.6e-17 61.8 0.0 2.4 2 1 0 2 2 2 2 Laminin G domain Laminin_G_2 PF02210.22 001007151.3_16124001_1 - 8.1e-14 52.2 0.0 1.1e-10 42.0 0.0 2.2 2 0 0 2 2 2 2 Laminin G domain PMP22_Claudin PF00822.18 001017736.1_16123001_2 - 7.7e-40 136.4 10.1 1.1e-39 135.8 10.1 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001017736.1_16123001_2 - 1.5e-10 41.0 10.2 4.5e-10 39.5 9.9 1.9 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Amastin PF07344.9 001017736.1_16123001_2 - 0.014 15.1 4.7 0.029 14.1 4.7 1.6 1 0 0 1 1 1 0 Amastin surface glycoprotein DUF4064 PF13273.4 001017736.1_16123001_2 - 1.3 9.3 8.0 2.1e+02 2.2 9.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF4064) Sulfotransfer_1 PF00685.25 183347.2_16124001_3 - 3.5e-75 252.8 0.1 5.7e-75 252.1 0.1 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 183347.2_16124001_3 - 5.3e-07 30.1 0.0 3.9e-05 24.0 0.0 2.2 2 0 0 2 2 2 2 Sulfotransferase family DUF4604 PF15377.4 001023580.1_16125001_1 - 9e-05 22.9 5.7 0.00015 22.2 5.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) 7tm_1 PF00001.19 001023580.1_16125001_1 - 0.015 14.4 0.2 0.021 13.9 0.2 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Fer4_18 PF13746.4 001023580.1_16125001_1 - 0.053 13.6 2.5 0.11 12.5 2.5 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain ABC_export PF16962.3 001023580.1_16125001_1 - 0.46 8.7 2.4 0.81 7.9 2.4 1.4 1 0 0 1 1 1 0 Putative ABC exporter FAM176 PF14851.4 001023580.1_16125001_1 - 0.93 9.0 4.2 11 5.6 0.3 2.3 2 0 0 2 2 2 0 FAM176 family AP3D1 PF06375.9 001023580.1_16125001_1 - 8 6.6 23.8 14 5.8 23.8 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Ets PF00178.20 001023580.1_16125001_2 - 1.1e-36 125.0 0.8 1.1e-36 125.0 0.8 2.5 4 0 0 4 4 4 1 Ets-domain SAM_PNT PF02198.14 001023580.1_16125001_2 - 9.7e-28 95.9 0.1 2e-27 94.9 0.1 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain OAD_gamma PF04277.11 001023580.1_16125001_2 - 0.57 10.7 4.0 1.3 9.5 4.0 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain FAM176 PF14851.4 001023580.1_16125001_2 - 3.7 7.1 5.3 0.57 9.7 0.8 1.8 2 0 0 2 2 2 0 FAM176 family Actin PF00022.17 213372.1_16126001_3 - 2.3e-132 441.4 0.0 5.6e-132 440.1 0.0 1.5 1 1 0 1 1 1 1 Actin rRNA_proc-arch PF13234.4 214768.1_16127001_3 - 1.6e-91 306.8 0.2 3.1e-91 305.8 0.2 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.10 214768.1_16127001_3 - 3.2e-57 192.6 0.4 6e-57 191.7 0.4 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.27 214768.1_16127001_3 - 2.4e-17 63.1 0.0 6.9e-17 61.6 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 214768.1_16127001_3 - 5.4e-07 29.8 0.0 6.3e-06 26.4 0.0 2.6 1 1 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.4 214768.1_16127001_3 - 0.02 15.0 0.0 0.13 12.4 0.0 2.4 2 1 1 3 3 3 0 AAA domain AAA_19 PF13245.4 214768.1_16127001_3 - 0.089 13.0 0.0 0.28 11.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain Stealth_CR1 PF17101.3 214768.1_16127001_3 - 0.21 11.2 0.4 0.53 9.9 0.4 1.7 1 0 0 1 1 1 0 Stealth protein CR1, conserved region 1 Guanylate_cyc PF00211.18 001309529.1_16126001_1 - 1.5e-61 207.1 0.0 2.3e-61 206.5 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.12 001309529.1_16126001_1 - 4.2e-45 153.7 0.1 1.3e-44 152.1 0.1 1.7 1 1 0 1 1 1 1 Heme NO binding associated HNOB PF07700.13 001309529.1_16126001_1 - 0.0014 18.5 0.0 0.0028 17.5 0.0 1.5 1 0 0 1 1 1 1 Haem-NO-binding DUF1298 PF06974.11 001309529.1_16126001_1 - 0.03 14.2 0.0 1.4 8.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1298) TMEM126 PF07114.9 001309529.1_16126001_1 - 0.038 13.2 0.0 0.073 12.3 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 126 Apo-CII PF05355.9 136943.1_16122120_3 - 1.1e-09 38.1 0.6 1.5e-09 37.6 0.6 1.2 1 0 0 1 1 1 1 Apolipoprotein C-II EGF_CA PF07645.13 204165.1_23527001_1 - 7.9e-67 221.1 137.1 5.1e-11 42.5 5.1 11.0 11 0 0 11 11 11 9 Calcium-binding EGF domain cEGF PF12662.5 204165.1_23527001_1 - 6.1e-55 182.6 67.9 6.2e-09 35.5 0.7 9.9 9 0 0 9 9 9 8 Complement Clr-like EGF-like FXa_inhibition PF14670.4 204165.1_23527001_1 - 5.9e-22 77.5 140.0 2.3e-06 27.7 9.0 11.1 11 0 0 11 11 11 6 Coagulation Factor Xa inhibitory site EGF_3 PF12947.5 204165.1_23527001_1 - 1.6e-09 37.6 115.3 0.0053 16.8 5.5 10.7 10 0 0 10 10 10 9 EGF domain ANATO PF01821.16 204165.1_23527001_1 - 4.5e-05 24.1 18.9 0.00047 20.8 5.5 8.7 9 1 1 10 10 10 2 Anaphylotoxin-like domain EGF PF00008.25 204165.1_23527001_1 - 0.0011 19.1 117.1 0.0054 16.9 8.9 11.0 9 0 0 9 9 9 6 EGF-like domain hEGF PF12661.5 204165.1_23527001_1 - 0.016 15.7 8.8 0.016 15.7 8.8 12.3 10 1 0 10 10 10 0 Human growth factor-like EGF KASH PF10541.7 204165.1_23527001_1 - 2.5 8.3 6.7 0.9 9.7 0.4 3.3 3 0 0 3 3 3 0 Nuclear envelope localisation domain Ldh_1_C PF02866.16 001316925.1_16123001_1 - 1.7e-41 141.8 0.0 3.2e-41 140.9 0.0 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.21 001316925.1_16123001_1 - 1.6e-38 131.8 0.1 4.1e-38 130.5 0.1 1.7 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Neuregulin PF02158.13 001277086.1_16127001_1 - 7.9e-148 493.0 15.8 1.2e-147 492.4 15.8 1.2 1 0 0 1 1 1 1 Neuregulin family I-set PF07679.14 001277086.1_16127001_1 - 2.9e-17 62.4 0.1 8.6e-17 60.9 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001277086.1_16127001_1 - 1.4e-14 54.3 0.1 3.7e-14 53.0 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001277086.1_16127001_1 - 6e-12 45.4 0.1 1.1e-11 44.5 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001277086.1_16127001_1 - 8.4e-11 41.9 0.8 2.7e-10 40.3 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 001277086.1_16127001_1 - 4.3e-06 26.6 0.0 1.1e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 001277086.1_16127001_1 - 3.5e-05 23.8 0.1 0.00018 21.5 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain C1-set PF07654.13 001277086.1_16127001_1 - 0.0093 16.3 0.0 0.024 14.9 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin C1-set domain V-set_CD47 PF08204.9 001277086.1_16127001_1 - 0.012 15.5 0.5 0.027 14.3 0.5 1.6 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain EGF_2 PF07974.11 001277086.1_16127001_1 - 0.015 15.6 5.7 0.015 15.6 5.7 2.8 3 0 0 3 3 3 0 EGF-like domain TMEM132D_C PF15706.3 001277086.1_16127001_1 - 0.13 11.9 0.7 0.92 9.2 0.0 2.6 3 0 0 3 3 3 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term BCDHK_Adom3 PF10436.7 213060.2_16126001_3 - 7.8e-39 133.0 0.0 1.2e-38 132.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.24 213060.2_16126001_3 - 5.3e-13 49.4 0.0 1.3e-12 48.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.4 213060.2_16126001_3 - 4.5e-06 26.4 0.0 0.00058 19.6 0.0 2.2 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF737 PF05300.9 001309796.1_16124001_3 - 6.1e-55 186.6 36.4 4.4e-53 180.5 36.4 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF737) DUF3292 PF11696.6 001309796.1_16124001_3 - 0.0011 17.3 4.7 0.0017 16.7 4.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3292) CHCH PF06747.11 001309796.1_16124001_3 - 0.017 15.1 1.8 0.027 14.5 0.6 1.9 2 0 0 2 2 2 0 CHCH domain DUF1829 PF08862.8 001309796.1_16124001_3 - 0.072 13.4 0.2 0.18 12.2 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF1829 PepSY_TM_like_2 PF16357.3 001309796.1_16124001_3 - 3.1 7.6 4.6 2.7 7.8 3.3 1.5 1 1 0 1 1 1 0 Putative PepSY_TM-like Cu-oxidase_2 PF07731.12 131802.1_16127001_2 - 5.7e-31 106.9 20.0 2e-14 53.4 2.4 6.6 6 1 0 6 6 6 5 Multicopper oxidase Cu-oxidase_3 PF07732.13 131802.1_16127001_2 - 5e-28 97.4 2.9 1.1e-09 38.2 0.0 6.2 5 1 0 5 5 5 3 Multicopper oxidase Antimicrobial17 PF08129.9 131802.1_16127001_2 - 0.03 14.2 0.2 0.89 9.5 0.1 2.9 3 0 0 3 3 3 0 Alpha/beta enterocin family SoxE PF06525.9 131802.1_16127001_2 - 0.095 12.0 0.0 13 5.1 0.0 3.2 3 0 0 3 3 3 0 Sulfocyanin (SoxE) domain Glutaredoxin PF00462.22 213021.1_16122001_2 - 2.6e-19 69.1 0.0 4.4e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Cyclin_N PF00134.21 001089445.1_16123001_1 - 7.3e-37 125.9 1.1 1.8e-36 124.6 1.1 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001089445.1_16123001_1 - 4.4e-20 71.8 0.0 3e-19 69.1 0.0 2.2 2 0 0 2 2 2 1 Cyclin, C-terminal domain K-cyclin_vir_C PF09080.8 001089445.1_16123001_1 - 0.0026 18.0 0.0 0.0041 17.4 0.0 1.2 1 0 0 1 1 1 1 K cyclin, C terminal Herp-Cyclin PF09241.8 001089445.1_16123001_1 - 0.013 16.0 0.1 0.036 14.6 0.1 1.7 1 0 0 1 1 1 0 Herpesviridae viral cyclin Myc_N PF01056.16 131412.1_16124001_2 - 1.7e-109 366.6 16.4 3e-109 365.8 16.4 1.4 1 0 0 1 1 1 1 Myc amino-terminal region Myc-LZ PF02344.13 131412.1_16124001_2 - 3.4e-13 49.3 14.8 1.3e-12 47.5 14.8 2.0 1 0 0 1 1 1 1 Myc leucine zipper domain HLH PF00010.24 131412.1_16124001_2 - 5.8e-13 48.4 7.4 7.9e-13 48.0 1.1 3.0 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain Ribosomal_60s PF00428.17 131412.1_16124001_2 - 0.24 11.9 12.9 0.55 10.7 12.9 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein TRAP_alpha PF03896.14 131412.1_16124001_2 - 2.2 7.3 7.2 4.7 6.2 7.2 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Usp PF00582.24 131412.1_16124001_2 - 2.7 8.4 8.4 3.7 7.9 6.6 1.9 2 0 0 2 2 2 0 Universal stress protein family DUF3439 PF11921.6 131412.1_16124001_3 - 0.52 10.2 9.5 0.12 12.2 5.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Sugar_tr PF00083.22 001111163.1_16124001_2 - 5.3e-83 279.2 29.2 1.7e-62 211.7 17.7 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.14 001111163.1_16124001_2 - 1.9e-34 119.0 35.3 2.6e-26 92.2 24.2 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.11 001111163.1_16124001_2 - 1.1e-08 33.8 3.8 1.1e-08 33.8 3.8 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) CGI-121 PF08617.8 001007373.1_16123001_1 - 5e-42 143.6 3.0 5e-42 143.6 3.0 1.4 2 0 0 2 2 2 1 Kinase binding protein CGI-121 OAD_gamma PF04277.11 001007373.1_16123001_2 - 2.2 8.8 5.5 4.3 7.9 5.5 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain PAX PF00292.16 131332.2_16125001_1 - 4e-71 236.7 0.9 6e-71 236.1 0.9 1.3 1 0 0 1 1 1 1 'Paired box' domain Homeobox PF00046.27 131332.2_16125001_1 - 2.6e-23 81.4 6.8 4.8e-23 80.6 6.8 1.5 1 0 0 1 1 1 1 Homeobox domain Pax7 PF12360.6 131332.2_16125001_1 - 3.2e-22 78.3 9.9 3.2e-22 78.3 9.9 1.9 2 0 0 2 2 2 1 Paired box protein 7 Homeobox_KN PF05920.9 131332.2_16125001_1 - 6.1e-05 22.7 0.8 0.00015 21.4 0.8 1.7 1 0 0 1 1 1 1 Homeobox KN domain HTH_23 PF13384.4 131332.2_16125001_1 - 0.00022 20.8 2.2 0.0043 16.7 0.1 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.4 131332.2_16125001_1 - 0.0046 17.4 5.5 0.11 13.0 0.0 3.2 2 1 1 3 3 3 1 Homeodomain-like domain Peptidase_C2 PF00648.19 200445.1_16126001_2 - 4e-129 429.7 0.0 5.6e-129 429.3 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 200445.1_16126001_2 - 4e-55 185.8 0.0 7e-55 185.1 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_8 PF13833.4 200445.1_16126001_2 - 7.9e-08 31.8 0.6 2.4e-05 23.9 0.2 3.3 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.30 200445.1_16126001_2 - 8.4e-07 28.0 0.5 0.0029 16.9 0.0 4.1 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.4 200445.1_16126001_2 - 0.0001 21.8 0.2 0.11 12.3 0.0 4.2 3 1 1 4 4 4 1 EF-hand domain EF-hand_7 PF13499.4 200445.1_16126001_2 - 0.00096 19.4 2.8 3.4 8.1 0.5 3.9 3 1 1 4 4 4 2 EF-hand domain pair Thiolase_N PF00108.21 001002207.1_16124001_3 - 3e-82 275.7 0.0 3.9e-82 275.4 0.0 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 001002207.1_16124001_3 - 1.1e-48 163.8 0.2 2e-48 162.9 0.2 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.8 001002207.1_16124001_3 - 0.00024 21.1 0.0 0.0008 19.4 0.0 1.9 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.8 001002207.1_16124001_3 - 0.0044 16.7 0.6 0.72 9.6 0.0 2.7 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.24 001002207.1_16124001_3 - 0.017 14.6 0.1 0.042 13.3 0.1 1.6 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain zf-C4 PF00105.16 001130592.2_16128001_1 - 1.2e-30 105.6 15.0 4.9e-30 103.7 15.0 2.1 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001130592.2_16128001_1 - 2.6e-23 82.6 1.4 5.5e-23 81.5 1.4 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Orn_Arg_deC_N PF02784.14 131801.2_16125001_1 - 1.3e-86 289.9 0.0 1.7e-86 289.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 131801.2_16125001_1 - 2.6e-36 123.9 0.0 4.8e-36 123.1 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain DUF5032 PF16435.3 131801.2_16125001_1 - 0.039 13.3 0.1 0.06 12.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5032) CUE PF02845.14 001328590.1_16123001_2 - 4.8e-15 54.8 0.2 9.5e-15 53.8 0.2 1.5 1 0 0 1 1 1 1 CUE domain C2 PF00168.28 001328590.1_16123001_2 - 9.5e-13 48.2 0.0 1.4e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 C2 domain HTH_8 PF02954.17 001328590.1_16123001_2 - 0.12 12.1 0.1 0.33 10.7 0.0 1.8 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family DeoC PF01791.7 001006097.2_16123001_3 - 2.9e-28 99.0 0.1 3.7e-28 98.6 0.1 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase Neuregulin PF02158.13 001044911.2_16126001_3 - 5.8e-148 493.4 15.8 8.7e-148 492.9 15.8 1.3 1 0 0 1 1 1 1 Neuregulin family I-set PF07679.14 001044911.2_16126001_3 - 3.1e-17 62.3 0.1 7.2e-17 61.1 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001044911.2_16126001_3 - 1.1e-14 54.6 0.1 3.1e-14 53.2 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001044911.2_16126001_3 - 4.9e-12 45.7 0.1 9.6e-12 44.8 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001044911.2_16126001_3 - 5.4e-11 42.6 0.7 2.2e-10 40.6 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 001044911.2_16126001_3 - 3.2e-06 27.0 0.0 7.9e-06 25.7 0.0 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 001044911.2_16126001_3 - 2.6e-05 24.2 0.1 0.00015 21.8 0.1 2.2 1 1 0 1 1 1 1 Immunoglobulin V-set domain EGF_2 PF07974.11 001044911.2_16126001_3 - 0.0018 18.5 6.1 0.0018 18.5 6.1 2.8 3 0 0 3 3 3 1 EGF-like domain EGF PF00008.25 001044911.2_16126001_3 - 0.0034 17.5 5.9 0.0034 17.5 5.9 2.8 3 0 0 3 3 3 1 EGF-like domain C1-set PF07654.13 001044911.2_16126001_3 - 0.0076 16.6 0.0 0.021 15.2 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin C1-set domain V-set_CD47 PF08204.9 001044911.2_16126001_3 - 0.011 15.6 0.4 0.025 14.5 0.4 1.5 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain hEGF PF12661.5 001044911.2_16126001_3 - 0.071 13.7 7.5 0.056 14.0 2.5 3.2 2 0 0 2 2 2 0 Human growth factor-like EGF TMEM132D_C PF15706.3 001044911.2_16126001_3 - 0.087 12.5 0.2 0.79 9.4 0.0 2.4 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Pribosyltran PF00156.25 199518.3_16125001_2 - 1.8e-21 76.2 0.1 2.5e-21 75.7 0.1 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.4 199518.3_16125001_2 - 0.047 13.0 0.0 0.073 12.4 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase DUF1640 PF07798.9 001351801.1_16123001_2 - 7.6e-55 185.5 12.4 1.4e-54 184.7 12.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Protein_K PF12283.6 001351801.1_16123001_2 - 0.06 13.4 0.7 0.24 11.5 0.3 2.2 2 0 0 2 2 2 0 Bacteriophage protein K GSHPx PF00255.17 144467.1_16122120_2 - 4.1e-31 106.6 0.0 6e-31 106.1 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase EF-hand_5 PF13202.4 144467.1_16122120_2 - 0.48 9.9 1.4 2.4 7.7 0.5 2.1 2 0 0 2 2 2 0 EF hand GSHPx PF00255.17 001279711.1_37522001_3 - 2.4e-36 123.5 0.0 3.8e-36 122.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione peroxidase NdhM PF10664.7 001279711.1_37522001_3 - 0.077 13.1 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Cyanobacterial and plastid NDH-1 subunit M zf-B_box PF00643.22 205563.1_16128001_1 - 1.5e-08 34.5 6.7 1.5e-08 34.5 6.7 4.4 4 0 0 4 4 4 2 B-box zinc finger fn3 PF00041.19 205563.1_16128001_1 - 1.8e-07 31.3 0.0 3.1e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain SPRY PF00622.26 205563.1_16128001_1 - 1.7e-06 28.0 0.0 9.2e-05 22.4 0.0 2.3 1 1 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 205563.1_16128001_1 - 2.4e-06 27.4 3.7 2.4e-06 27.4 3.7 4.6 4 1 1 5 5 4 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 205563.1_16128001_1 - 3.7e-06 26.7 4.4 5.4e-06 26.2 1.9 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 205563.1_16128001_1 - 5.7e-06 26.0 1.4 5.7e-06 26.0 1.4 4.6 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) PRY PF13765.4 205563.1_16128001_1 - 5.5e-05 22.6 0.1 0.00014 21.2 0.1 1.8 1 0 0 1 1 1 1 SPRY-associated domain zf-RING_5 PF14634.4 205563.1_16128001_1 - 0.00086 19.1 0.7 0.00086 19.1 0.7 4.8 4 0 0 4 4 4 1 zinc-RING finger domain CEBP_ZZ PF16366.3 205563.1_16128001_1 - 0.0042 17.1 3.8 0.0042 17.1 3.8 3.0 3 0 0 3 3 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-RING_2 PF13639.4 205563.1_16128001_1 - 0.014 15.6 2.0 0.014 15.6 2.0 4.8 5 0 0 5 5 4 0 Ring finger domain Rad50_zn_hook PF04423.12 205563.1_16128001_1 - 0.34 10.6 4.8 0.81 9.5 0.1 2.7 2 0 0 2 2 2 0 Rad50 zinc hook motif Trm112p PF03966.14 205563.1_16128001_1 - 0.42 11.1 8.4 15 6.1 0.1 3.8 3 1 0 3 3 3 0 Trm112p-like protein 7tm_1 PF00001.19 001318772.1_23525001_1 - 4.2e-60 203.1 21.1 6.1e-60 202.6 21.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001318772.1_23525001_1 - 1.6e-09 37.4 21.6 2.3e-09 36.9 21.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.19 001318780.1_16123001_2 - 3.6e-62 209.9 22.6 3.6e-62 209.9 22.6 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001318780.1_16123001_2 - 1.1e-10 41.2 20.5 1.9e-10 40.4 20.5 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001318780.1_16123001_2 - 1.9e-06 27.3 20.3 3.9e-06 26.3 20.3 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001318780.1_16123001_2 - 1.4e-05 24.8 19.8 0.00013 21.6 19.8 2.0 1 1 0 1 1 1 1 Olfactory receptor MotA_ExbB PF01618.14 001318780.1_16123001_2 - 0.064 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 MotA/TolQ/ExbB proton channel family 7tm_1 PF00001.19 182886.2_16123001_2 - 3.6e-62 209.9 22.6 3.6e-62 209.9 22.6 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 182886.2_16123001_2 - 1.1e-10 41.2 20.5 1.9e-10 40.4 20.5 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 182886.2_16123001_2 - 1.9e-06 27.3 20.3 3.9e-06 26.3 20.3 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 182886.2_16123001_2 - 1.4e-05 24.8 19.8 0.00013 21.6 19.8 2.0 1 1 0 1 1 1 1 Olfactory receptor MotA_ExbB PF01618.14 182886.2_16123001_2 - 0.064 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 MotA/TolQ/ExbB proton channel family 7tm_1 PF00001.19 001319057.1_16126001_3 - 5.5e-60 202.7 17.2 1.1e-59 201.7 17.2 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001319057.1_16126001_3 - 1.5e-11 44.0 15.5 2.5e-11 43.3 15.5 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Pkinase PF00069.23 001318225.2_23529001_3 - 1.4e-62 211.3 0.0 1.8e-62 211.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001318225.2_23529001_3 - 4.2e-28 98.2 0.0 6.1e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001318225.2_23529001_3 - 2.8e-06 26.7 0.2 4.5e-06 26.0 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001318225.2_23529001_3 - 0.0012 18.1 0.0 0.0019 17.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 001318225.2_23529001_3 - 0.0042 16.6 0.3 0.0073 15.8 0.3 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 001318225.2_23529001_3 - 0.0063 16.3 0.0 0.01 15.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Ldh_1_C PF02866.16 001316891.1_23524001_3 - 6.5e-44 149.7 0.0 1.2e-43 148.8 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.21 001316891.1_23524001_3 - 1.5e-39 135.2 0.1 2.4e-39 134.5 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain zf-C4 PF00105.16 204536.1_23524001_1 - 1.4e-32 111.8 16.2 1.4e-32 111.8 16.2 2.0 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 204536.1_23524001_1 - 2.7e-24 85.8 0.0 5e-24 84.9 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor ELP6 PF09807.7 001103142.1_16123001_1 - 3e-110 367.4 0.0 3.6e-110 367.2 0.0 1.1 1 0 0 1 1 1 1 Elongation complex protein 6 ERbeta_N PF12497.6 204794.2_23528001_3 - 9.4e-54 179.9 7.5 1.7e-53 179.1 7.5 1.4 1 0 0 1 1 1 1 Estrogen receptor beta Hormone_recep PF00104.28 204794.2_23528001_3 - 6e-35 120.6 1.2 8.7e-35 120.1 1.2 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 204794.2_23528001_3 - 8.6e-31 106.1 13.4 8.6e-31 106.1 13.4 2.2 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Sds3 PF08598.9 001007935.1_23525001_1 - 7.7e-24 84.8 8.6 4.7e-23 82.2 9.9 1.4 1 1 1 2 2 2 1 Sds3-like HSP70 PF00012.18 001007935.1_23525001_1 - 5 5.0 5.5 8.1 4.3 5.5 1.2 1 0 0 1 1 1 0 Hsp70 protein SET PF00856.26 001007337.2_16126001_1 - 4.1e-11 43.4 1.5 9.4e-11 42.3 0.1 2.3 2 0 0 2 2 2 1 SET domain DUF2303 PF10065.7 001007337.2_16126001_1 - 0.055 12.5 0.1 3.8 6.5 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2303) PEPCK PF00821.16 205471.1_23526001_1 - 2.9e-275 914.0 0.0 3.4e-275 913.7 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase TPK_catalytic PF04263.14 205471.1_23526001_1 - 0.053 13.4 0.0 0.097 12.6 0.0 1.3 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, catalytic domain Orai-1 PF07856.10 001030658.1_23522001_2 - 3.1e-70 235.3 4.3 3.7e-70 235.1 4.3 1.1 1 0 0 1 1 1 1 Mediator of CRAC channel activity 7TM_GPCR_Str PF10326.7 001030658.1_23522001_2 - 0.042 13.1 0.9 3.4 6.8 0.1 2.1 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Str DUF1772 PF08592.9 001030658.1_23522001_2 - 0.1 12.8 6.3 0.91 9.7 3.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) Gmx_para_CXXCG PF09535.8 001030658.1_23522001_2 - 0.12 11.5 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (Gmx_para_CXXCG) SPA PF08616.8 001012781.1_23528001_3 - 2.9e-15 56.1 0.1 1.7e-14 53.6 0.0 2.1 2 0 0 2 2 2 1 Stabilization of polarity axis Avl9 PF09794.7 001012781.1_23528001_3 - 2.7e-08 32.8 0.0 4.4e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Transport protein Avl9 DENN PF02141.19 001012781.1_23528001_3 - 4.9e-05 23.2 3.3 4.9e-05 23.2 3.3 1.9 2 0 0 2 2 2 1 DENN (AEX-3) domain zf-C4 PF00105.16 205326.1_23525001_3 - 2e-32 111.3 16.3 2e-32 111.3 16.3 2.1 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 205326.1_23525001_3 - 4.1e-24 85.2 0.9 7.3e-24 84.4 0.0 1.8 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor Ig_3 PF13927.4 001004395.1_23528001_1 - 2.4e-78 258.6 0.4 1.6e-13 50.9 0.0 7.3 7 0 0 7 7 7 6 Immunoglobulin domain I-set PF07679.14 001004395.1_23528001_1 - 3.4e-71 235.2 0.0 2.4e-15 56.2 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_2 PF13895.4 001004395.1_23528001_1 - 9.5e-59 195.6 0.1 3.8e-11 43.1 0.0 6.9 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 001004395.1_23528001_1 - 1e-52 176.1 0.1 4.1e-09 36.3 0.0 6.6 6 0 0 6 6 6 6 Immunoglobulin domain fn3 PF00041.19 001004395.1_23528001_1 - 4.3e-48 161.4 3.2 7.2e-18 64.6 0.0 4.7 4 0 0 4 4 4 4 Fibronectin type III domain V-set PF07686.15 001004395.1_23528001_1 - 2.9e-21 75.5 8.8 0.0099 15.9 0.0 9.2 6 4 2 9 9 9 4 Immunoglobulin V-set domain Ig_5 PF16681.3 001004395.1_23528001_1 - 2.4e-14 53.4 0.0 0.014 15.6 0.0 6.4 6 0 0 6 6 6 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 001004395.1_23528001_1 - 6.7e-08 32.3 0.1 0.23 11.4 0.0 5.6 6 0 0 6 6 5 2 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 001004395.1_23528001_1 - 9.2e-08 31.9 1.0 0.049 13.6 0.0 5.4 5 0 0 5 5 5 1 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.3 001004395.1_23528001_1 - 1.8e-07 31.5 1.4 0.00025 21.4 0.1 3.5 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Sp38 PF07354.10 001004395.1_23528001_1 - 3e-05 22.9 0.0 0.0067 15.2 0.0 3.2 3 0 0 3 3 3 1 Zona-pellucida-binding protein (Sp38) Adeno_E3_CR1 PF02440.13 001004395.1_23528001_1 - 0.0015 18.1 0.2 3.9 7.2 0.0 3.8 3 0 0 3 3 3 1 Adenovirus E3 region protein CR1 Interfer-bind PF09294.8 001004395.1_23528001_1 - 0.02 15.1 0.0 0.092 12.9 0.0 2.1 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III C2-set PF05790.13 001004395.1_23528001_1 - 0.052 13.6 1.4 13 5.9 0.0 4.2 6 0 0 6 6 5 0 Immunoglobulin C2-set domain DUF3584 PF12128.6 001030785.2_23529001_1 - 0.85 6.9 47.8 1.2 6.4 47.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) GAS PF13851.4 001030785.2_23529001_1 - 0.97 8.6 57.7 0.11 11.8 32.9 3.3 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding ADIP PF11559.6 001030785.2_23529001_1 - 3.3 7.6 66.3 0.021 14.8 14.9 5.1 2 1 3 5 5 5 0 Afadin- and alpha -actinin-Binding zf-C4 PF00105.16 130919.1_16124001_1 - 1.2e-29 102.5 13.8 2.1e-29 101.6 13.8 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 130919.1_16124001_1 - 2.5e-22 79.4 0.1 5.8e-22 78.2 0.1 1.6 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor AROS PF15684.3 001006239.3_23522001_2 - 3.4e-34 118.0 1.5 4.6e-34 117.6 1.5 1.1 1 0 0 1 1 1 1 Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1 OTT_1508_deam PF14441.4 001006239.3_23522001_3 - 0.081 12.7 1.9 0.29 11.0 1.9 1.9 1 0 0 1 1 1 0 OTT_1508-like deaminase Oest_recep PF02159.13 205183.2_23525001_1 - 1.8e-67 226.0 7.3 1.8e-67 226.0 7.3 1.9 2 0 0 2 2 2 1 Oestrogen receptor Hormone_recep PF00104.28 205183.2_23525001_1 - 1.5e-34 119.3 3.8 2.7e-34 118.5 3.8 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 205183.2_23525001_1 - 1.7e-31 108.4 13.9 2.9e-31 107.6 13.9 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) ESR1_C PF12743.5 205183.2_23525001_1 - 1.1e-19 69.8 3.6 1.1e-19 69.8 3.6 2.1 2 0 0 2 2 2 1 Oestrogen-type nuclear receptor final C-terminal Thyroglob_assoc PF16597.3 205183.2_23525001_1 - 0.045 13.9 0.1 0.089 13.0 0.1 1.5 1 0 0 1 1 1 0 Thyroglobulin_1 repeat associated disordered domain zf-C3HC4_3 PF13920.4 001031434.1_23527001_2 - 1.3e-06 28.1 11.6 2.6e-06 27.0 11.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001031434.1_23527001_2 - 7e-05 22.5 14.6 0.00014 21.5 14.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001031434.1_23527001_2 - 0.00023 20.8 14.6 0.00042 20.0 14.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001031434.1_23527001_2 - 0.00053 19.8 13.7 0.0027 17.5 14.3 1.9 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 001031434.1_23527001_2 - 0.0016 18.5 13.0 0.0033 17.5 13.0 1.5 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.4 001031434.1_23527001_2 - 0.0082 15.8 9.2 0.016 14.9 9.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF4407 PF14362.4 001031434.1_23527001_2 - 0.0089 15.3 1.6 0.0089 15.3 1.6 6.2 3 1 3 6 6 4 2 Domain of unknown function (DUF4407) zf-rbx1 PF12678.5 001031434.1_23527001_2 - 0.014 15.6 8.0 0.03 14.5 8.0 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 001031434.1_23527001_2 - 0.016 15.1 10.3 0.032 14.1 10.3 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001031434.1_23527001_2 - 0.58 10.2 8.5 1.6 8.8 8.5 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.5 001031434.1_23527001_2 - 0.64 10.0 4.8 1.2 9.1 4.8 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Bromodomain PF00439.23 205165.1_23529001_1 - 2e-112 367.3 31.9 3.2e-23 81.5 0.1 6.9 7 0 0 7 7 7 6 Bromodomain BAH PF01426.16 205165.1_23529001_1 - 1.2e-52 176.7 4.1 4.4e-28 97.4 1.4 2.9 2 0 0 2 2 2 2 BAH domain HMG_box PF00505.17 205165.1_23529001_1 - 7.5e-13 48.6 2.7 3.4e-12 46.5 0.0 2.8 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.8 205165.1_23529001_1 - 3.5e-08 33.8 0.0 1.1e-07 32.1 0.0 1.9 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.10 205165.1_23529001_1 - 0.0031 17.3 0.1 0.044 13.6 0.0 2.6 2 0 0 2 2 2 1 CHDNT (NUC034) domain NTP_transferase PF00483.21 001003491.2_16124001_1 - 5.5e-52 176.7 0.0 8.6e-52 176.0 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.22 001003491.2_16124001_1 - 4.7e-13 48.2 11.1 9.9e-08 31.3 1.5 3.3 2 1 2 4 4 4 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.5 001003491.2_16124001_1 - 5.4e-09 36.4 0.0 7.5e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.4 001003491.2_16124001_1 - 4e-05 23.1 4.6 5.2e-05 22.8 1.7 2.4 2 0 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase zf-C4 PF00105.16 205447.2_23523001_2 - 6.1e-30 103.4 15.9 6.1e-30 103.4 15.9 2.3 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 205447.2_23523001_2 - 3.8e-17 62.4 0.1 9.7e-17 61.1 0.0 1.7 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor Oest_recep PF02159.13 001279770.1_37529001_2 - 1.3e-39 135.8 7.3 6.1e-39 133.5 3.3 2.3 2 0 0 2 2 2 1 Oestrogen receptor Hormone_recep PF00104.28 001279770.1_37529001_2 - 3e-34 118.3 3.7 5.3e-34 117.5 3.7 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001279770.1_37529001_2 - 1.2e-30 105.6 13.9 1.2e-30 105.6 13.9 3.3 2 1 1 3 3 3 1 Zinc finger, C4 type (two domains) AP3D1 PF06375.9 001279770.1_37529001_2 - 6.8 6.8 9.0 11 6.1 9.0 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 ERbeta_N PF12497.6 001279774.1_37529001_3 - 2.8e-34 117.2 4.3 5e-34 116.4 4.3 1.4 1 0 0 1 1 1 1 Estrogen receptor beta Hormone_recep PF00104.28 001279774.1_37529001_3 - 1.3e-33 116.2 4.2 2.1e-33 115.5 4.2 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001279774.1_37529001_3 - 1.6e-30 105.2 13.5 1.6e-30 105.2 13.5 2.1 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Sep15_SelM PF08806.9 178294.5_16122001_1 - 3.3e-22 78.4 0.0 5.4e-22 77.7 0.0 1.3 1 0 0 1 1 1 1 Sep15/SelM redox domain Rdx PF10262.7 001351374.1_23522001_1 - 4.1e-08 33.2 0.0 7.8e-08 32.3 0.0 1.5 1 1 0 1 1 1 1 Rdx family DsbC_N PF10411.7 001351374.1_23522001_1 - 0.023 14.0 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 Disulfide bond isomerase protein N-terminus Rdx PF10262.7 001166327.2_23522001_1 - 4.3e-08 33.1 0.0 8.1e-08 32.2 0.0 1.5 1 1 0 1 1 1 1 Rdx family DsbC_N PF10411.7 001166327.2_23522001_1 - 0.024 14.0 0.0 0.035 13.4 0.0 1.3 1 0 0 1 1 1 0 Disulfide bond isomerase protein N-terminus zf-NF-X1 PF01422.15 001166327.2_23522001_2 - 7.8 6.5 12.1 0.1 12.6 3.4 2.2 2 0 0 2 2 2 0 NF-X1 type zinc finger Hormone_recep PF00104.28 131217.4_16124001_2 - 3.9e-40 137.5 0.0 7.2e-40 136.6 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 131217.4_16124001_2 - 6e-32 109.8 17.0 6e-32 109.8 17.0 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Nuc_recep-AF1 PF11825.6 131217.4_16124001_2 - 4.4e-27 94.3 16.3 9.6e-27 93.2 16.3 1.6 1 0 0 1 1 1 1 Nuclear/hormone receptor activator site AF-1 PHBC_N PF12551.6 131217.4_16124001_3 - 0.049 13.3 1.1 0.11 12.2 1.1 1.5 1 0 0 1 1 1 0 Poly-beta-hydroxybutyrate polymerase N terminal DALR_1 PF05746.13 001123326.1_16126001_1 - 7.4e-16 58.3 0.0 1.3e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 DALR anticodon binding domain Calcyon PF06387.9 204565.1_23524001_2 - 8.1e-87 289.8 0.1 1.1e-86 289.3 0.1 1.2 1 0 0 1 1 1 1 D1 dopamine receptor-interacting protein (calcyon) zf-C2H2 PF00096.24 001290417.1_16129001_1 - 3.5e-26 90.0 62.8 3.5e-05 23.9 3.0 9.6 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001290417.1_16129001_1 - 3.8e-18 64.5 64.9 0.0062 17.1 2.8 10.1 9 0 0 9 9 9 8 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001290417.1_16129001_1 - 5.5e-08 32.8 65.4 1.2e-07 31.8 2.3 11.5 12 1 0 12 12 11 5 Zinc-finger double domain zf-H2C2_5 PF13909.4 001290417.1_16129001_1 - 6.4e-08 32.1 32.1 7e-06 25.6 3.3 7.7 7 0 0 7 7 7 2 C2H2-type zinc-finger domain zf-Di19 PF05605.10 001290417.1_16129001_1 - 0.00021 21.3 38.9 0.018 15.2 0.8 7.5 6 2 1 7 7 7 3 Drought induced 19 protein (Di19), zinc-binding DUF3268 PF11672.6 001290417.1_16129001_1 - 0.0069 16.6 0.9 0.033 14.4 0.9 2.2 1 0 0 1 1 1 1 zinc-finger-containing domain CpXC PF14353.4 001290417.1_16129001_1 - 0.019 14.9 13.0 15 5.5 0.0 6.2 5 1 0 5 5 5 0 CpXC protein Actin_micro PF17003.3 001290417.1_16129001_1 - 0.2 10.7 10.3 33 3.4 0.0 5.4 5 1 1 6 6 6 0 Putative actin-like family zf-C2H2_11 PF16622.3 001290417.1_16129001_1 - 0.23 11.1 32.1 0.064 12.9 0.3 6.4 6 0 0 6 6 6 0 zinc-finger C2H2-type PGA2 PF07543.10 001290417.1_16129001_1 - 1.2 9.0 3.4 4.4 7.1 3.4 2.0 1 0 0 1 1 1 0 Protein trafficking PGA2 zf-C2H2_jaz PF12171.6 001290417.1_16129001_1 - 2 8.7 34.5 0.59 10.4 0.2 7.6 8 0 0 8 8 8 0 Zinc-finger double-stranded RNA-binding IBR PF01485.19 001326695.1_16129001_2 - 3.5e-18 65.5 28.0 1.5e-13 50.7 11.2 5.5 5 1 0 5 5 5 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.23 001326695.1_16129001_2 - 0.0025 17.5 7.5 0.0025 17.5 7.5 5.7 5 2 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) RWD PF05773.20 001030623.2_23526001_2 - 1.2e-24 86.7 0.0 2.3e-24 85.8 0.0 1.5 1 0 0 1 1 1 1 RWD domain IBR PF01485.19 001030623.2_23526001_2 - 2.3e-16 59.7 22.8 1.1e-12 47.8 5.3 5.4 4 1 1 5 5 5 2 IBR domain, a half RING-finger domain zf-RING_5 PF14634.4 001030623.2_23526001_2 - 0.00042 20.1 16.9 0.00042 20.1 16.9 4.7 5 1 0 5 5 5 1 zinc-RING finger domain DFF-C PF09033.8 001002631.1_16124001_2 - 2.6e-59 199.7 5.8 2.6e-59 199.7 5.8 1.5 2 0 0 2 2 2 1 DNA Fragmentation factor 45kDa, C terminal domain CIDE-N PF02017.13 001002631.1_16124001_2 - 1.4e-26 92.2 0.0 5.5e-26 90.3 0.0 2.0 2 0 0 2 2 2 1 CIDE-N domain HR1 PF02185.14 001002631.1_16124001_2 - 0.014 15.4 9.7 0.11 12.5 1.3 2.7 2 0 0 2 2 2 0 Hr1 repeat HisKA PF00512.23 001002631.1_16124001_2 - 2.5 8.1 6.1 0.74 9.8 2.3 2.1 2 1 0 2 2 2 0 His Kinase A (phospho-acceptor) domain Pkinase PF00069.23 001039807.1_16129001_1 - 3.3e-32 111.8 0.0 5.1e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001039807.1_16129001_1 - 8.4e-30 103.8 0.0 1.8e-29 102.7 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Activin_recp PF01064.21 001039807.1_16129001_1 - 2.6e-10 41.1 12.7 2.6e-10 41.1 12.7 2.1 2 0 0 2 2 2 1 Activin types I and II receptor domain APH PF01636.21 001039807.1_16129001_1 - 0.02 14.7 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family eIF-3c_N PF05470.10 213463.1_16127001_2 - 3e-252 838.1 28.9 2.7e-250 831.7 28.9 2.1 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.25 213463.1_16127001_2 - 3.2e-17 62.8 0.5 1.3e-16 60.9 0.1 2.3 2 0 0 2 2 2 1 PCI domain DUF2779 PF11074.6 213463.1_16127001_2 - 0.01 16.2 0.5 0.29 11.5 0.0 3.3 2 1 0 2 2 2 0 Domain of unknown function(DUF2779) GRP PF07172.9 213463.1_16127001_2 - 0.43 11.2 8.5 0.36 11.4 2.9 2.7 2 0 0 2 2 2 0 Glycine rich protein family EAF PF09816.7 001002162.1_16124001_1 - 3.1e-21 75.5 0.0 5.8e-21 74.6 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor AF-4 PF05110.11 001002162.1_16124001_1 - 0.83 7.5 33.1 1.2 7.0 33.1 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Cwf_Cwc_15 PF04889.10 001002162.1_16124001_1 - 0.95 9.0 8.7 1.5 8.3 8.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SOG2 PF10428.7 001002162.1_16124001_1 - 1.3 8.1 16.9 1.7 7.7 16.9 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Macoilin PF09726.7 001002162.1_16124001_1 - 4.5 5.6 10.0 6.2 5.1 10.0 1.1 1 0 0 1 1 1 0 Transmembrane protein PHO4 PF01384.18 213179.1_16126001_1 - 3.1e-136 453.7 4.0 3.1e-136 453.7 4.0 1.6 2 0 0 2 2 2 1 Phosphate transporter family TGFb_propeptide PF00688.16 131342.2_16126001_1 - 4.5e-54 183.7 1.5 6.7e-54 183.1 1.5 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 131342.2_16126001_1 - 5.2e-34 117.1 0.6 1e-33 116.2 0.6 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain DFF40 PF09230.8 194404.1_16123001_1 - 2.2e-97 325.0 4.0 3e-97 324.5 4.0 1.2 1 0 0 1 1 1 1 DNA fragmentation factor 40 kDa CIDE-N PF02017.13 194404.1_16123001_1 - 2e-27 94.9 0.0 5.8e-27 93.4 0.0 1.8 1 0 0 1 1 1 1 CIDE-N domain Ribosomal_L18p PF00861.20 194404.1_16123001_1 - 0.12 12.6 1.2 0.2 11.9 0.2 1.8 2 0 0 2 2 2 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast DED PF01335.19 001313772.1_16125001_3 - 1.4e-32 111.7 8.8 2.3e-23 82.1 4.0 2.7 2 0 0 2 2 2 2 Death effector domain Peptidase_C14 PF00656.20 001313772.1_16125001_3 - 1.1e-08 35.2 0.1 1.8e-08 34.5 0.1 1.3 1 0 0 1 1 1 1 Caspase domain Hist_deacetyl PF00850.17 200990.1_16125001_3 - 1.1e-77 261.5 0.0 1.5e-77 261.0 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Homeobox PF00046.27 001009885.2_16123001_1 - 1.3e-21 76.0 6.6 2.3e-21 75.2 6.6 1.4 1 0 0 1 1 1 1 Homeobox domain QLQ PF08880.9 001009885.2_16123001_1 - 0.0014 18.2 0.4 0.0029 17.2 0.4 1.5 1 0 0 1 1 1 1 QLQ Frizzled PF01534.15 001042761.2_16126001_2 - 4.4e-120 400.5 15.6 7.6e-120 399.7 15.6 1.4 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.20 001042761.2_16126001_2 - 1e-27 96.9 8.6 3e-27 95.4 8.6 1.9 1 0 0 1 1 1 1 Fz domain Pkinase_Tyr PF07714.15 001145996.1_16124001_3 - 9.5e-36 123.3 0.0 1.3e-35 122.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001145996.1_16124001_3 - 6.9e-34 117.3 0.0 1.1e-33 116.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.10 001145996.1_16124001_3 - 1.4e-15 56.3 0.9 3.1e-15 55.2 0.9 1.6 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.21 001145996.1_16124001_3 - 1.5e-12 48.2 11.0 4.7e-12 46.7 11.0 1.9 1 0 0 1 1 1 1 Activin types I and II receptor domain FTA2 PF13095.4 001145996.1_16124001_3 - 0.023 14.2 0.0 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Serpin PF00079.18 001309823.1_16124001_1 - 3.3e-96 322.7 1.4 3.9e-96 322.5 1.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) PBP1_TM PF14812.4 001309823.1_16124001_1 - 0.032 14.5 0.5 0.064 13.6 0.5 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nop14 PF04147.10 001309823.1_16124001_1 - 0.18 9.8 5.2 0.25 9.4 5.2 1.2 1 0 0 1 1 1 0 Nop14-like family DUF4637 PF15470.4 001309823.1_16124001_1 - 0.96 9.1 6.4 1.5 8.5 6.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF2457 PF10446.7 001309823.1_16124001_1 - 4.8 6.1 10.3 7.3 5.5 10.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF3464 PF11947.6 001309823.1_16124001_2 - 0.64 9.6 6.7 0.98 9.0 6.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) GTP_cyclohydroI PF01227.20 131667.1_16124001_2 - 1.8e-74 248.9 0.2 2.5e-74 248.4 0.2 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.4 131667.1_16124001_2 - 9.5e-05 22.4 0.0 0.00019 21.4 0.0 1.5 1 0 0 1 1 1 1 QueF-like protein MCU PF04678.11 001077325.1_16124001_2 - 1.7e-71 239.9 0.3 2.3e-71 239.5 0.3 1.2 1 0 0 1 1 1 1 Mitochondrial calcium uniporter SIM_C PF06621.10 178222.3_16126001_3 - 2.4e-119 398.6 9.6 3.9e-119 397.9 9.6 1.3 1 0 0 1 1 1 1 Single-minded protein C-terminus PAS_3 PF08447.10 178222.3_16126001_3 - 9.3e-26 89.8 0.8 1e-18 67.2 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 178222.3_16126001_3 - 8.3e-21 74.1 1.7 3.6e-15 55.9 0.2 2.6 3 0 0 3 3 3 2 PAS domain PAS PF00989.23 178222.3_16126001_3 - 1e-17 64.0 0.0 8.7e-12 44.9 0.0 2.4 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 178222.3_16126001_3 - 1.9e-06 27.6 0.6 3.5e-05 23.6 0.8 2.3 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 178222.3_16126001_3 - 2.6e-06 27.5 0.0 0.002 18.3 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 178222.3_16126001_3 - 0.00022 21.3 0.0 0.011 15.8 0.0 2.4 2 0 0 2 2 2 1 PAS fold Sds3 PF08598.9 001030102.2_16125001_3 - 8.1e-25 88.0 10.4 8.8e-23 81.3 14.0 1.9 1 1 1 2 2 2 1 Sds3-like Myb_DNA-bind_4 PF13837.4 001030102.2_16125001_3 - 0.011 15.9 2.8 2.1 8.7 0.0 2.8 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain RCC1 PF00415.16 213176.1_16126001_1 - 9e-58 192.6 4.5 4.7e-15 55.8 0.0 6.7 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 213176.1_16126001_1 - 1.8e-31 107.1 10.5 6.5e-09 35.2 0.0 6.3 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat Arm PF00514.21 001001889.1_16128001_3 - 1.9e-40 135.5 20.0 1.4e-07 31.2 0.1 11.8 13 0 0 13 13 13 7 Armadillo/beta-catenin-like repeat Cnd1 PF12717.5 001001889.1_16128001_3 - 2e-08 34.3 2.5 0.0056 16.6 0.3 4.3 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.18 001001889.1_16128001_3 - 2.8e-06 26.1 2.8 0.0015 17.1 1.0 3.2 3 0 0 3 3 3 1 Adaptin N terminal region HEAT_2 PF13646.4 001001889.1_16128001_3 - 7.4e-06 26.1 5.6 0.042 14.1 0.2 5.0 5 0 0 5 5 5 1 HEAT repeats HEAT PF02985.20 001001889.1_16128001_3 - 2.8e-05 23.9 2.6 25 5.3 0.0 5.9 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.4 001001889.1_16128001_3 - 7.5e-05 23.0 10.4 1.7 9.0 0.1 6.4 6 1 1 7 7 6 2 HEAT-like repeat KAP PF05804.10 001001889.1_16128001_3 - 0.00073 17.7 1.8 0.022 12.8 1.5 2.9 1 1 2 3 3 3 2 Kinesin-associated protein (KAP) DUF3361 PF11841.6 001001889.1_16128001_3 - 0.0014 18.5 1.6 2.9 7.7 0.0 4.3 2 1 1 4 4 4 1 Domain of unknown function (DUF3361) RasGEF_N_2 PF14663.4 001001889.1_16128001_3 - 0.0027 17.9 3.7 8.2 6.7 0.0 4.6 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Atx10homo_assoc PF09759.7 001001889.1_16128001_3 - 0.01 15.7 0.7 0.12 12.3 0.1 3.0 3 1 1 4 4 4 0 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.11 001001889.1_16128001_3 - 0.04 13.2 4.6 0.41 9.9 0.1 3.3 2 1 1 3 3 3 0 Armadillo-like Queuosine_synth PF02547.13 001001889.1_16128001_3 - 0.04 12.9 0.7 0.061 12.3 0.1 1.5 2 0 0 2 2 2 0 Queuosine biosynthesis protein EGF PF00008.25 131549.2_16129001_3 - 1.1e-215 696.8 548.3 3.6e-09 36.6 5.8 36.0 35 0 0 35 35 35 35 EGF-like domain hEGF PF12661.5 131549.2_16129001_3 - 4.5e-129 417.1 487.8 2.5e-06 27.8 10.3 37.8 37 1 1 38 38 36 35 Human growth factor-like EGF EGF_CA PF07645.13 131549.2_16129001_3 - 9.2e-54 179.3 552.4 5.6e-09 35.9 8.9 36.6 20 10 16 36 36 33 22 Calcium-binding EGF domain EGF_2 PF07974.11 131549.2_16129001_3 - 3.3e-34 116.8 621.0 0.00097 19.3 9.5 36.6 37 0 0 37 37 34 28 EGF-like domain Ank_2 PF12796.5 131549.2_16129001_3 - 9.4e-33 112.5 27.4 2.8e-11 43.7 1.3 4.3 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank PF00023.28 131549.2_16129001_3 - 2e-26 91.1 7.5 4.7e-06 26.7 0.0 6.9 6 0 0 6 6 6 6 Ankyrin repeat DUF3454 PF11936.6 131549.2_16129001_3 - 3.3e-26 91.3 26.0 3.3e-26 91.3 26.0 2.6 2 0 0 2 2 1 1 Domain of unknown function (DUF3454) Notch PF00066.15 131549.2_16129001_3 - 6e-25 87.3 50.8 6.5e-11 42.4 10.7 17.2 18 3 2 20 20 4 3 LNR domain NODP PF07684.10 131549.2_16129001_3 - 1.8e-24 85.5 0.0 2.1e-23 82.0 0.0 3.2 1 0 0 1 1 1 1 NOTCH protein Ank_5 PF13857.4 131549.2_16129001_3 - 2.1e-21 75.5 12.8 3.7e-08 33.4 0.6 5.7 3 2 2 5 5 5 4 Ankyrin repeats (many copies) NOD PF06816.11 131549.2_16129001_3 - 8.2e-21 73.2 0.0 1.4e-20 72.5 0.0 1.4 1 0 0 1 1 1 1 NOTCH protein Ank_3 PF13606.4 131549.2_16129001_3 - 2.8e-18 64.0 3.1 0.00065 19.8 0.0 6.6 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.4 131549.2_16129001_3 - 3.1e-15 56.2 1.4 1.9e-05 24.9 0.2 4.9 3 2 2 5 5 4 4 Ankyrin repeats (many copies) cEGF PF12662.5 131549.2_16129001_3 - 1.7e-05 24.5 12.6 6.7e-05 22.6 3.6 34.5 35 0 0 35 35 33 15 Complement Clr-like EGF-like FXa_inhibition PF14670.4 131549.2_16129001_3 - 0.078 13.1 481.2 0.023 14.8 4.5 36.7 16 9 20 36 36 33 0 Coagulation Factor Xa inhibitory site Tropomyosin PF00261.18 001352039.1_23524001_3 - 1.8e-87 292.5 62.7 2.2e-87 292.2 62.7 1.1 1 0 0 1 1 1 1 Tropomyosin Tropomyosin_1 PF12718.5 001352039.1_23524001_3 - 1.1e-22 80.6 59.0 3.8e-19 69.1 29.1 3.1 1 1 0 2 2 2 2 Tropomyosin like Laminin_II PF06009.10 001352039.1_23524001_3 - 1.9e-05 24.6 28.5 0.0001 22.2 6.4 3.3 1 1 1 3 3 3 2 Laminin Domain II TMF_DNA_bd PF12329.6 001352039.1_23524001_3 - 0.0022 17.8 11.6 0.0022 17.8 11.6 4.7 1 1 1 3 3 3 1 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.7 001352039.1_23524001_3 - 0.15 12.0 53.0 0.12 12.3 31.3 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.10 001352039.1_23524001_3 - 0.18 11.0 3.1 0.35 10.1 0.3 2.0 2 0 0 2 2 2 0 Reovirus sigma C capsid protein CALCOCO1 PF07888.9 001352039.1_23524001_3 - 0.21 10.0 43.5 0.27 9.6 43.5 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like SNARE PF05739.17 001352039.1_23524001_3 - 0.37 10.7 3.5 3.9 7.4 0.1 3.4 3 0 0 3 3 3 0 SNARE domain CLZ PF16526.3 001352039.1_23524001_3 - 0.5 10.6 37.5 0.05 13.8 4.5 4.7 2 2 2 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels UPF0693 PF16088.3 001352039.1_23524001_3 - 0.68 10.1 8.2 0.56 10.4 0.2 3.3 2 1 1 3 3 3 0 UPF0693 family DUF1664 PF07889.10 001352039.1_23524001_3 - 1.3 8.9 24.9 1.3 8.9 5.2 3.4 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF3508 PF12018.6 001352039.1_23524001_3 - 2 7.7 20.8 0.95 8.8 5.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3508) DUF4407 PF14362.4 001352039.1_23524001_3 - 4.3 6.5 37.2 3 7.0 18.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF745 PF05335.11 001352039.1_23524001_3 - 4.6 6.8 36.8 17 4.9 26.4 2.9 1 1 0 2 2 2 0 Protein of unknown function (DUF745) TraF_2 PF13729.4 001352039.1_23524001_3 - 5.4 6.2 6.3 3.7 6.7 0.9 2.3 2 0 0 2 2 2 0 F plasmid transfer operon, TraF, protein XhlA PF10779.7 001352039.1_23524001_3 - 5.8 7.0 35.5 1.1 9.4 1.3 4.9 2 1 3 5 5 5 0 Haemolysin XhlA HOOK PF05622.10 001352039.1_23524001_3 - 7.1 4.5 44.3 9.1 4.2 44.3 1.1 1 0 0 1 1 1 0 HOOK protein Lebercilin PF15619.4 001352039.1_23524001_3 - 7.4 6.0 53.5 0.44 10.0 16.7 3.4 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Fib_alpha PF08702.8 001352039.1_23524001_3 - 7.7 6.6 26.7 0.82 9.7 9.1 2.4 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Golgin_A5 PF09787.7 001352039.1_23524001_3 - 9.9 5.4 48.6 0.097 12.0 15.1 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 BCL9 PF11502.6 001005575.1_16129001_3 - 9.4e-17 60.4 1.1 9.4e-17 60.4 1.1 3.5 3 0 0 3 3 3 1 B-cell lymphoma 9 protein V-set PF07686.15 001122617.1_16123001_1 - 6.1e-09 35.9 0.1 1.4e-08 34.7 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 001122617.1_16123001_1 - 0.00029 21.0 0.1 0.0011 19.2 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001122617.1_16123001_1 - 0.00058 19.7 0.0 0.0015 18.4 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001122617.1_16123001_1 - 0.0082 16.6 0.5 0.03 14.8 0.1 2.2 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001122617.1_16123001_1 - 0.0082 16.2 0.5 0.039 14.0 0.1 2.4 2 1 0 2 2 2 1 Immunoglobulin domain RhoGAP PF00620.25 001004548.1_16127001_1 - 3.3e-34 117.8 0.1 7.3e-34 116.6 0.1 1.6 1 0 0 1 1 1 1 RhoGAP domain BNIP2 PF12496.6 001128394.1_16123001_1 - 3.1e-41 140.9 0.4 6e-41 139.9 0.4 1.5 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.4 001128394.1_16123001_1 - 4.6e-31 107.6 0.2 6.8e-31 107.1 0.2 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.18 001128394.1_16123001_1 - 5.1e-08 32.7 0.3 1.1e-07 31.6 0.3 1.5 1 1 0 1 1 1 1 CRAL/TRIO domain Pkinase_Tyr PF07714.15 131104.1_16126001_2 - 3.5e-92 308.2 0.0 5.6e-92 307.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 131104.1_16126001_2 - 1.7e-46 158.6 0.0 2.8e-46 157.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 131104.1_16126001_2 - 2e-18 66.1 0.1 4.7e-18 64.9 0.1 1.7 1 0 0 1 1 1 1 SH2 domain BTK PF00779.17 131104.1_16126001_2 - 2.9e-13 49.2 5.0 6.3e-13 48.2 5.0 1.6 1 0 0 1 1 1 1 BTK motif PH PF00169.27 131104.1_16126001_2 - 3.5e-11 43.4 0.1 3.5e-11 43.4 0.1 2.3 2 0 0 2 2 2 1 PH domain SH3_9 PF14604.4 131104.1_16126001_2 - 1.6e-07 30.9 0.1 3.3e-07 29.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 131104.1_16126001_2 - 2.6e-07 30.0 0.0 5.3e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain APH PF01636.21 131104.1_16126001_2 - 0.024 14.4 0.0 6.2 6.5 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Det1 PF09737.7 199670.1_16125001_3 - 6.2e-194 644.6 3.1 7.5e-194 644.3 3.1 1.1 1 0 0 1 1 1 1 De-etiolated protein 1 Det1 V_ATPase_I PF01496.17 213069.1_16126001_2 - 1.1e-299 995.8 0.0 1.4e-299 995.6 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Takusan PF04822.11 213069.1_16126001_2 - 0.16 11.8 0.4 0.35 10.6 0.4 1.5 1 0 0 1 1 1 0 Takusan MARVEL PF01284.21 001135977.2_16123001_3 - 2.2e-13 50.4 16.8 2.2e-13 50.4 16.8 1.8 2 0 0 2 2 2 1 Membrane-associating domain DUF4231 PF14015.4 001135977.2_16123001_3 - 6.2 7.2 8.1 43 4.5 3.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) BNIP3 PF06553.10 205571.2_16126001_3 - 1.2e-84 282.8 0.1 1.6e-84 282.3 0.1 1.1 1 0 0 1 1 1 1 BNIP3 wnt PF00110.17 130946.3_16127001_1 - 7.4e-92 308.0 25.2 1.1e-91 307.5 25.2 1.2 1 0 0 1 1 1 1 wnt family wnt PF00110.17 130946.3_16127001_2 - 3.4e-91 305.8 24.9 5.1e-91 305.3 24.9 1.2 1 0 0 1 1 1 1 wnt family Serpin PF00079.18 205152.2_23524001_2 - 1.1e-115 386.7 0.3 1.3e-115 386.5 0.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Mago_nashi PF02792.12 001308098.1_23522001_1 - 8.7e-80 265.6 0.2 1e-79 265.4 0.2 1.1 1 0 0 1 1 1 1 Mago nashi protein DUF3729 PF12526.6 181735.1_16124001_2 - 0.46 11.9 6.9 0.86 11.1 6.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3729) Forkhead PF00250.16 181735.1_16124001_3 - 1.5e-38 130.8 3.4 1.9e-38 130.5 0.1 2.6 3 0 0 3 3 3 1 Forkhead domain 7tm_1 PF00001.19 001310056.2_23526001_2 - 3.4e-36 124.7 15.0 5.7e-36 124.0 15.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001310056.2_23526001_2 - 1.1 8.1 21.5 0.037 13.0 13.8 2.2 2 1 0 2 2 2 0 Taste receptor protein (TAS2R) GHBP PF12772.5 001083578.1_16125001_2 - 2.7e-58 197.8 10.4 6.7e-32 111.1 2.6 2.1 1 1 1 2 2 2 2 Growth hormone receptor binding EpoR_lig-bind PF09067.8 001083578.1_16125001_2 - 2.3e-10 40.5 4.1 2.3e-10 40.5 4.1 1.9 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 001083578.1_16125001_2 - 0.0011 19.2 0.3 0.003 17.7 0.3 1.7 1 0 0 1 1 1 1 Fibronectin type III domain Phage_tail_APC PF16778.3 001083578.1_16125001_2 - 0.0056 16.4 0.0 0.016 14.9 0.0 1.8 1 0 0 1 1 1 1 Phage tail assembly chaperone protein GST_C_3 PF14497.4 131734.3_16122001_1 - 3.7e-21 75.0 0.1 1e-20 73.6 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 131734.3_16122001_1 - 1e-15 57.6 0.1 6.6e-13 48.6 0.0 2.3 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 131734.3_16122001_1 - 6.7e-07 29.4 0.0 1.4e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 131734.3_16122001_1 - 0.0025 17.6 0.0 0.0055 16.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin2_C PF04399.11 131734.3_16122001_1 - 0.068 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain SM-ATX PF14438.4 001128349.1_16127001_1 - 2.3e-20 72.4 1.4 2.9e-20 72.1 0.1 1.9 2 0 0 2 2 2 1 Ataxin 2 SM domain LsmAD PF06741.11 001128349.1_16127001_1 - 3.6e-16 59.4 4.2 3.6e-16 59.4 4.2 2.2 2 0 0 2 2 2 1 LsmAD domain PAM2 PF07145.13 001128349.1_16127001_1 - 8.6e-07 28.1 0.9 3.1e-06 26.4 0.9 2.1 1 0 0 1 1 1 1 Ataxin-2 C-terminal region zf-H2C2_2 PF13465.4 001278140.1_23526001_2 - 1.4e-08 34.6 29.0 2.5e-06 27.5 2.4 5.2 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001278140.1_23526001_2 - 1.7e-08 34.5 23.7 0.0044 17.6 2.9 4.4 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.24 001278140.1_23526001_2 - 4.6e-08 33.0 35.9 6.5e-05 23.0 4.4 4.8 5 0 0 5 5 5 3 Zinc finger, C2H2 type KRAB PF01352.25 001278140.1_23526001_2 - 3e-07 29.9 1.8 7.5e-07 28.6 1.8 1.7 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 001278140.1_23526001_2 - 0.0019 18.0 15.5 0.032 14.1 2.2 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_8 PF15909.3 001278140.1_23526001_2 - 0.018 15.2 10.5 0.027 14.7 2.0 2.9 1 1 1 2 2 2 0 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.8 001278140.1_23526001_2 - 1.4 9.0 8.8 0.54 10.3 3.1 3.3 3 0 0 3 3 3 0 Zinc ribbon domain Med3 PF11593.6 001044897.3_16129001_1 - 1.1 8.2 3.0 1.7 7.6 3.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Vitellogenin_N PF01347.20 001044897.3_16129001_3 - 5.2e-172 573.4 1.3 1.2e-170 568.8 0.0 2.2 2 0 0 2 2 2 1 Lipoprotein amino terminal region DUF1943 PF09172.9 001044897.3_16129001_3 - 2.1e-62 211.1 0.0 4.9e-62 209.8 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1943) DUF1944 PF09175.8 001044897.3_16129001_3 - 8.1e-57 191.6 0.0 1.4e-56 190.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1944) Macoilin PF09726.7 001044897.3_16129001_3 - 0.045 12.2 7.2 0.07 11.5 7.2 1.2 1 0 0 1 1 1 0 Transmembrane protein FAM117 PF15388.4 001044897.3_16129001_3 - 0.1 11.9 9.4 0.19 10.9 9.4 1.4 1 0 0 1 1 1 0 Protein Family FAM117 DLIC PF05783.9 001044897.3_16129001_3 - 0.2 10.3 4.1 0.31 9.7 4.1 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Apt1 PF10351.7 001044897.3_16129001_3 - 0.4 9.4 11.5 0.61 8.8 11.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain FAM199X PF15814.3 001044897.3_16129001_3 - 0.59 9.0 14.7 1 8.2 14.7 1.3 1 0 0 1 1 1 0 Protein family FAM199X SOBP PF15279.4 001044897.3_16129001_3 - 1.7 9.0 6.6 3.1 8.2 6.6 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein PAP1 PF08601.8 001044897.3_16129001_3 - 2.9 7.4 16.1 4.7 6.7 16.1 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 AF-4 PF05110.11 001044897.3_16129001_3 - 3 5.7 24.2 4.3 5.2 24.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CCDC106 PF15794.3 001044897.3_16129001_3 - 3.3 7.2 10.8 6.5 6.3 10.8 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 CCDC24 PF15669.3 001044897.3_16129001_3 - 3.7 7.2 9.2 8.8 6.0 9.2 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family RAP1 PF07218.9 001044897.3_16129001_3 - 6 4.9 16.1 9.4 4.2 16.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RSRP PF17069.3 001044897.3_16129001_3 - 6.2 6.2 35.5 11 5.4 35.5 1.3 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 LIM PF00412.20 201588.1_16126001_3 - 1.3e-66 220.6 36.2 6.5e-18 64.6 1.2 4.3 4 0 0 4 4 4 4 LIM domain Paxillin PF03535.11 201588.1_16126001_3 - 2.3e-58 197.3 20.9 5.6e-58 196.1 20.9 1.6 1 0 0 1 1 1 1 Paxillin family V-set PF07686.15 001135096.1_16124001_1 - 1e-08 35.2 6.3 0.0013 18.7 0.2 4.9 5 0 0 5 5 5 2 Immunoglobulin V-set domain Ig_2 PF13895.4 001135096.1_16124001_1 - 9.2e-07 29.0 13.6 0.029 14.6 0.1 4.5 2 1 1 3 3 3 2 Immunoglobulin domain C2-set PF05790.13 001135096.1_16124001_1 - 0.00013 21.9 2.3 0.15 12.1 0.2 3.5 3 0 0 3 3 3 2 Immunoglobulin C2-set domain ig PF00047.23 001135096.1_16124001_1 - 0.0003 20.8 11.8 1.1 9.3 0.1 4.9 4 2 0 4 4 4 2 Immunoglobulin domain Izumo-Ig PF16706.3 001135096.1_16124001_1 - 0.019 14.9 0.2 11 6.0 0.0 3.6 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain ATG27 PF09451.8 001135096.1_16124001_1 - 0.029 14.1 0.4 0.11 12.2 0.1 2.0 2 1 0 2 2 2 0 Autophagy-related protein 27 I-set PF07679.14 001135096.1_16124001_1 - 0.12 12.3 4.5 21 5.1 0.4 4.0 4 1 0 4 4 4 0 Immunoglobulin I-set domain DUF1049 PF06305.9 001135096.1_16124001_1 - 3.8 7.3 5.3 0.79 9.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) Sid-5 PF17204.1 001135096.1_16124001_1 - 7.2 6.7 11.1 1.5 8.9 0.8 3.4 3 1 0 3 3 3 0 Sid-5 family Caveolin PF01146.15 001024162.1_16124001_3 - 1.9e-59 199.2 2.0 2.8e-59 198.7 2.0 1.2 1 0 0 1 1 1 1 Caveolin Vitellogenin_N PF01347.20 001025189.2_16129001_2 - 1.8e-168 561.7 0.4 1.3e-166 555.5 0.0 2.3 2 0 0 2 2 2 2 Lipoprotein amino terminal region DUF1943 PF09172.9 001025189.2_16129001_2 - 1.9e-62 211.2 0.0 5.7e-62 209.6 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1943) DUF1944 PF09175.8 001025189.2_16129001_2 - 1.1e-57 194.4 0.0 1.9e-57 193.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1944) Macoilin PF09726.7 001025189.2_16129001_2 - 0.077 11.4 7.3 0.11 10.8 7.3 1.1 1 0 0 1 1 1 0 Transmembrane protein DLIC PF05783.9 001025189.2_16129001_2 - 0.15 10.8 3.4 0.22 10.2 3.4 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) FAM199X PF15814.3 001025189.2_16129001_2 - 0.33 9.8 14.9 0.55 9.1 14.9 1.2 1 0 0 1 1 1 0 Protein family FAM199X SOBP PF15279.4 001025189.2_16129001_2 - 0.58 10.5 6.2 1.1 9.6 6.2 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein RSRP PF17069.3 001025189.2_16129001_2 - 0.8 9.1 34.8 1.3 8.4 34.8 1.2 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Apt1 PF10351.7 001025189.2_16129001_2 - 2.1 7.0 13.7 3.2 6.4 13.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain CCDC24 PF15669.3 001025189.2_16129001_2 - 3.5 7.3 8.8 7.8 6.2 8.8 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family RAP1 PF07218.9 001025189.2_16129001_2 - 4 5.5 15.5 6.2 4.8 15.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PAP1 PF08601.8 001025189.2_16129001_2 - 5.6 6.5 15.7 10 5.6 15.7 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 Sec10 PF07393.9 001113796.1_16125001_2 - 8.3e-160 533.4 22.3 1.2e-157 526.4 16.0 3.3 2 1 0 2 2 2 1 Exocyst complex component Sec10 Jnk-SapK_ap_N PF09744.7 001113796.1_16125001_2 - 0.00097 19.2 5.7 0.0013 18.9 3.1 2.6 2 0 0 2 2 2 1 JNK_SAPK-associated protein-1 TMPIT PF07851.11 001113796.1_16125001_2 - 0.12 11.5 4.9 0.86 8.6 0.2 2.6 2 0 0 2 2 2 0 TMPIT-like protein MbeD_MobD PF04899.10 001113796.1_16125001_2 - 0.58 10.2 4.8 19 5.3 0.0 3.3 3 0 0 3 3 3 0 MbeD/MobD like V_ATPase_I PF01496.17 001113796.1_16125001_2 - 0.76 7.5 10.8 0.12 10.2 6.9 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Phasin PF05597.9 001113796.1_16125001_2 - 1.2 9.1 9.0 7.7 6.4 0.6 4.3 4 0 0 4 4 4 0 Poly(hydroxyalcanoate) granule associated protein (phasin) OmpH PF03938.12 001113796.1_16125001_2 - 1.3 8.8 7.7 1.4 8.7 5.4 2.3 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF1664 PF07889.10 001113796.1_16125001_2 - 2.1 8.2 7.8 0.85 9.5 1.2 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) TelA PF05816.9 001113796.1_16125001_2 - 2.5 7.0 11.2 0.33 9.8 0.5 3.2 4 0 0 4 4 4 0 Toxic anion resistance protein (TelA) Crystall PF00030.17 001018125.1_16122001_2 - 1.3e-53 179.0 8.7 7.1e-29 99.7 1.3 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin wnt PF00110.17 130980.1_16124001_3 - 2.3e-120 401.7 24.8 3e-120 401.3 24.8 1.1 1 0 0 1 1 1 1 wnt family DUF3915 PF13054.4 198146.2_16127001_2 - 0.3 11.0 5.2 0.51 10.2 5.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Pkinase PF00069.23 198146.2_16127001_3 - 6.4e-77 258.3 0.0 8.8e-77 257.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 198146.2_16127001_3 - 2.1e-37 128.7 0.0 2.9e-37 128.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.27 198146.2_16127001_3 - 1.3e-17 64.1 0.1 2.8e-17 63.0 0.1 1.6 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.4 198146.2_16127001_3 - 9.5e-10 38.1 0.0 2.1e-09 37.0 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.22 198146.2_16127001_3 - 2.3e-08 34.5 7.6 4.3e-08 33.6 7.6 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain PH_11 PF15413.4 198146.2_16127001_3 - 0.0049 17.1 0.0 0.012 15.9 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Crystall PF00030.17 001002586.1_16123001_3 - 2.4e-52 174.9 8.7 4.3e-26 90.8 0.6 2.3 2 0 0 2 2 2 2 Beta/Gamma crystallin ANF_receptor PF01094.26 001328156.1_16128001_3 - 9.9e-51 172.7 0.0 1.4e-50 172.2 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 001328156.1_16128001_3 - 8.7e-49 165.0 0.1 1.5e-48 164.2 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 001328156.1_16128001_3 - 8.1e-44 148.4 0.0 1.4e-43 147.6 0.0 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001328156.1_16128001_3 - 3.5e-17 62.5 0.0 6.2e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 NOD PF06816.11 001328156.1_16128001_3 - 0.092 12.2 0.1 1.3 8.5 0.0 2.5 2 0 0 2 2 2 0 NOTCH protein Noggin PF05806.10 130982.1_16122001_1 - 1.1e-101 339.1 4.6 1.3e-101 338.9 4.6 1.0 1 0 0 1 1 1 1 Noggin Lig_chan PF00060.24 131894.1_16126001_1 - 1.3e-58 196.9 0.1 2.1e-58 196.3 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel ANF_receptor PF01094.26 131894.1_16126001_1 - 6.6e-55 186.5 0.0 1.1e-54 185.8 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan-Glu_bd PF10613.7 131894.1_16126001_1 - 3.6e-45 152.7 0.0 6.8e-45 151.8 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 131894.1_16126001_1 - 6.5e-25 87.7 0.0 1.4e-24 86.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.4 131894.1_16126001_1 - 0.001 18.7 0.0 0.0037 16.9 0.0 1.9 2 0 0 2 2 2 1 Periplasmic binding protein Lipocalin PF00061.21 152961.3_16122001_1 - 8.8e-28 97.2 2.3 1.1e-27 96.9 2.3 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 152961.3_16122001_1 - 9.5e-09 35.1 0.8 1.3e-08 34.7 0.8 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Caveolin PF01146.15 212651.1_16124001_3 - 2.3e-59 199.0 2.0 3.3e-59 198.5 2.0 1.2 1 0 0 1 1 1 1 Caveolin SCF PF02404.13 001018123.1_16122001_1 - 1.8e-22 79.9 1.0 2.5e-22 79.4 1.0 1.3 1 1 0 1 1 1 1 Stem cell factor BatD PF13584.4 001018123.1_16122001_1 - 0.015 14.0 0.0 0.029 13.2 0.0 1.4 1 0 0 1 1 1 0 Oxygen tolerance TMEM154 PF15102.4 001018123.1_16122001_1 - 0.063 13.0 0.0 0.095 12.5 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family DUF3439 PF11921.6 001018123.1_16122001_1 - 0.096 12.5 4.0 0.17 11.8 4.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) ANF_receptor PF01094.26 198339.1_16126001_2 - 3e-63 213.9 0.0 4.5e-63 213.3 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 198339.1_16126001_2 - 1.4e-59 200.1 0.0 2.3e-59 199.4 0.0 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 198339.1_16126001_2 - 7.2e-46 155.0 0.0 1.4e-45 154.0 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 198339.1_16126001_2 - 1.7e-24 86.4 0.0 2.9e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DUF2061 PF09834.7 198339.1_16126001_2 - 0.08 13.3 0.2 0.26 11.7 0.2 1.9 1 0 0 1 1 1 0 Predicted membrane protein (DUF2061) ANF_receptor PF01094.26 214806.1_16127001_1 - 5.2e-64 216.4 0.0 6.9e-64 216.0 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 214806.1_16127001_1 - 1.6e-59 199.9 0.0 2.6e-59 199.2 0.0 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 214806.1_16127001_1 - 2.6e-42 143.5 0.1 5.8e-42 142.4 0.1 1.6 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 214806.1_16127001_1 - 2.4e-22 79.4 0.0 4.6e-22 78.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.4 214806.1_16127001_1 - 0.018 14.6 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding protein DUF2061 PF09834.7 214806.1_16127001_1 - 0.067 13.6 0.0 0.21 12.0 0.0 1.9 1 0 0 1 1 1 0 Predicted membrane protein (DUF2061) SGS PF05002.13 001007361.1_16124001_3 - 3.3e-33 113.5 1.3 9.6e-33 112.0 1.3 1.8 1 0 0 1 1 1 1 SGS domain CS PF04969.14 001007361.1_16124001_3 - 4.5e-18 65.9 1.4 4.5e-18 65.9 1.4 1.7 2 0 0 2 2 2 1 CS domain TPR_1 PF00515.26 001007361.1_16124001_3 - 1.2e-05 24.7 1.9 4.5e-05 23.0 1.2 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.15 001007361.1_16124001_3 - 1.4e-05 24.7 4.3 0.00018 21.2 1.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.4 001007361.1_16124001_3 - 0.0086 16.4 2.7 0.015 15.7 2.2 1.7 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.4 001007361.1_16124001_3 - 0.0089 16.0 0.5 0.028 14.5 0.5 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat P4Ha_N PF08336.9 001007361.1_16124001_3 - 0.047 13.5 1.3 0.27 11.1 0.0 2.2 1 1 1 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region YusW PF14039.4 001007361.1_16124001_3 - 0.2 12.1 2.0 1.3 9.4 0.2 2.4 1 1 1 2 2 2 0 YusW-like protein TPR_16 PF13432.4 001007361.1_16124001_3 - 0.31 11.6 2.9 0.7 10.5 2.9 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat SIR2 PF02146.15 001044708.1_16123001_1 - 1.7e-54 184.3 0.0 2.6e-54 183.7 0.0 1.2 1 0 0 1 1 1 1 Sir2 family Troponin PF00992.18 001017587.2_16123001_3 - 1.3e-47 161.3 11.4 2.4e-47 160.5 11.4 1.4 1 0 0 1 1 1 1 Troponin Tup_N PF08581.8 001017587.2_16123001_3 - 0.023 14.9 1.8 0.023 14.9 1.8 2.0 2 0 0 2 2 2 0 Tup N-terminal Lipoprotein_20 PF13942.4 001017587.2_16123001_3 - 0.025 14.4 3.9 0.025 14.4 2.6 1.6 1 1 0 1 1 1 0 YfhG lipoprotein DUF2730 PF10805.6 001017587.2_16123001_3 - 0.18 11.8 3.7 0.2 11.6 2.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) DUF2408 PF10303.7 001017587.2_16123001_3 - 1.1 9.7 9.8 3.8 7.9 9.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) DivIC PF04977.13 001017587.2_16123001_3 - 2 8.1 5.4 0.93 9.2 0.7 2.3 2 0 0 2 2 2 0 Septum formation initiator DUF1664 PF07889.10 001017587.2_16123001_3 - 2 8.3 6.3 0.75 9.7 2.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TMPIT PF07851.11 001017587.2_16123001_3 - 7.9 5.5 11.3 0.96 8.5 2.2 2.3 1 1 1 2 2 2 0 TMPIT-like protein IncA PF04156.12 001017587.2_16123001_3 - 8.8 5.9 11.2 19 4.9 10.6 1.9 1 1 0 1 1 1 0 IncA protein Sushi PF00084.18 001136253.2_16122001_1 - 0.00012 22.5 0.1 0.0002 21.8 0.1 1.4 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) ERGIC_N PF13850.4 001136253.2_16122001_1 - 0.03 14.5 0.0 0.057 13.6 0.0 1.4 1 0 0 1 1 1 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) LIM PF00412.20 001305559.2_16122001_1 - 1.8e-12 47.1 6.5 2.9e-12 46.5 6.5 1.3 1 0 0 1 1 1 1 LIM domain zinc_ribbon_9 PF14369.4 001305559.2_16122001_1 - 0.066 13.4 6.9 0.13 12.4 2.6 2.3 2 0 0 2 2 2 0 zinc-ribbon Lar_restr_allev PF14354.4 001305559.2_16122001_1 - 0.08 13.2 5.0 0.39 11.0 5.0 2.1 1 1 0 1 1 1 0 Restriction alleviation protein Lar DUF329 PF03884.12 001305559.2_16122001_1 - 0.082 12.5 7.1 3.8 7.2 2.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF329) DZR PF12773.5 001305559.2_16122001_1 - 1.3 9.0 8.0 7.1 6.6 8.1 2.1 1 1 0 1 1 1 0 Double zinc ribbon GFA PF04828.12 001305559.2_16122001_1 - 1.5 9.1 0.1 1.5 9.1 0.1 2.9 2 1 1 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme zinc_ribbon_2 PF13240.4 001305559.2_16122001_1 - 1.8 8.3 11.6 2.7 7.7 0.2 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Zn-ribbon_8 PF09723.8 001305559.2_16122001_1 - 4.3 7.4 8.6 27 4.9 5.2 2.4 2 0 0 2 2 2 0 Zinc ribbon domain zf-ribbon_3 PF13248.4 001305559.2_16122001_1 - 5 6.5 7.6 1.4 8.3 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain Sushi PF00084.18 001359933.1_16122001_1 - 0.00011 22.6 0.1 0.00017 22.0 0.1 1.3 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) DEAD PF00270.27 001282047.3_23527001_3 - 5.9e-42 143.3 0.4 5.9e-42 143.3 0.4 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001282047.3_23527001_3 - 2.1e-27 95.6 0.8 1.2e-26 93.1 0.5 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.4 001282047.3_23527001_3 - 0.0022 17.3 0.2 0.004 16.4 0.2 1.3 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit ERGIC_N PF13850.4 153373.1_16122120_1 - 0.015 15.5 0.1 0.036 14.3 0.1 1.5 1 1 1 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) 7tm_1 PF00001.19 180972.2_16123001_1 - 1.6e-34 119.2 37.1 3.9e-34 118.0 37.1 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 180972.2_16123001_1 - 3e-09 36.9 23.5 4.6e-09 36.3 17.0 2.5 2 2 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 180972.2_16123001_1 - 6.9e-08 32.1 25.9 2.3e-07 30.4 25.9 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 180972.2_16123001_1 - 0.0058 15.8 18.5 0.0058 15.8 18.5 2.5 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.19 180970.1_16122001_1 - 8.6e-32 110.3 34.6 3.1e-31 108.5 34.6 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 180970.1_16122001_1 - 1.3e-11 44.7 15.1 1.3e-11 44.7 15.1 2.6 1 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 180970.1_16122001_1 - 3.3e-10 39.6 31.5 1.1e-09 37.9 31.5 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 180970.1_16122001_1 - 0.0022 17.3 21.3 0.0022 17.3 21.3 2.5 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx NMU PF02070.13 001277922.1_23522001_2 - 2.9e-12 46.1 2.7 6.5e-12 45.0 2.7 1.6 1 0 0 1 1 1 1 Neuromedin U MCM PF00493.21 212569.1_16126001_1 - 6.8e-134 446.0 0.0 1e-133 445.4 0.0 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_OB PF17207.1 212569.1_16126001_1 - 3.2e-33 114.1 0.2 7.3e-33 113.0 0.2 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.4 212569.1_16126001_1 - 8.4e-21 74.4 0.7 2.4e-20 72.9 0.7 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.19 212569.1_16126001_1 - 5e-08 32.5 0.1 3.7e-05 23.1 0.0 2.8 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.12 212569.1_16126001_1 - 9.1e-06 25.6 0.0 2.3e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) MCM_bind PF09739.7 212569.1_16126001_1 - 0.0013 17.2 0.2 0.0022 16.4 0.2 1.3 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor AAA_3 PF07726.9 212569.1_16126001_1 - 0.019 14.7 0.0 0.042 13.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Runt PF00853.17 212858.2_16124001_1 - 8.5e-74 245.2 0.1 1.5e-73 244.3 0.1 1.4 1 0 0 1 1 1 1 Runt domain RunxI PF08504.9 212858.2_16124001_1 - 6.4e-41 139.0 5.0 2e-40 137.4 5.0 1.9 1 0 0 1 1 1 1 Runx inhibition domain Septin PF00735.16 001024418.1_16123001_2 - 7.3e-115 382.9 0.7 9.8e-115 382.5 0.7 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 001024418.1_16123001_2 - 4.3e-08 33.1 0.0 9e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001024418.1_16123001_2 - 1.7e-07 31.2 1.0 2.9e-06 27.1 0.3 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AIG1 PF04548.14 001024418.1_16123001_2 - 6.2e-06 25.6 0.1 1e-05 24.9 0.1 1.3 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.21 001024418.1_16123001_2 - 3.9e-05 23.6 2.4 0.074 13.0 0.5 3.2 2 1 1 3 3 3 2 Dynamin family GTP_EFTU PF00009.25 001024418.1_16123001_2 - 0.0004 19.8 0.3 0.025 14.0 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Roc PF08477.11 001024418.1_16123001_2 - 0.00046 20.3 0.2 0.00091 19.3 0.2 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.25 001024418.1_16123001_2 - 0.0014 19.0 0.0 0.0031 17.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.4 001024418.1_16123001_2 - 0.0022 18.2 0.0 0.0042 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 001024418.1_16123001_2 - 0.0023 18.1 0.0 0.0052 16.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Ras PF00071.20 001024418.1_16123001_2 - 0.0038 16.7 0.1 0.012 15.1 0.1 1.8 1 0 0 1 1 1 1 Ras family FtsK_SpoIIIE PF01580.16 001024418.1_16123001_2 - 0.0047 16.2 0.1 0.008 15.4 0.1 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family DUF1542 PF07564.9 001024418.1_16123001_2 - 0.016 15.3 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) G-alpha PF00503.18 001024418.1_16123001_2 - 0.018 14.1 1.6 0.038 13.0 1.6 1.6 1 1 0 1 1 1 0 G-protein alpha subunit NB-ARC PF00931.20 001024418.1_16123001_2 - 0.018 14.0 0.0 0.038 12.9 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_29 PF13555.4 001024418.1_16123001_2 - 0.027 14.0 0.1 0.059 13.0 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.16 001024418.1_16123001_2 - 0.033 13.6 0.1 0.06 12.7 0.1 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_32 PF13654.4 001024418.1_16123001_2 - 0.036 12.7 0.1 0.084 11.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.24 001024418.1_16123001_2 - 0.039 13.5 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.4 001024418.1_16123001_2 - 0.054 13.1 0.1 0.3 10.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain IIGP PF05049.11 001024418.1_16123001_2 - 0.086 11.8 0.7 0.14 11.1 0.1 1.5 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) PduV-EutP PF10662.7 001024418.1_16123001_2 - 0.092 12.3 0.1 0.87 9.2 0.0 2.5 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation TEA PF01285.16 001001340.2_23523001_3 - 3.2e-13 49.4 0.9 7.4e-13 48.2 0.9 1.7 1 1 0 1 1 1 1 TEA/ATTS domain family MCM PF00493.21 001025533.1_16126001_3 - 4.9e-136 453.0 0.3 6.8e-136 452.6 0.3 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_OB PF17207.1 001025533.1_16126001_3 - 1e-33 115.8 0.8 2.1e-33 114.8 0.8 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.4 001025533.1_16126001_3 - 1.2e-16 61.0 0.8 3.4e-16 59.6 0.8 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.19 001025533.1_16126001_3 - 2e-07 30.4 0.0 7e-07 28.7 0.0 1.9 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.9 001025533.1_16126001_3 - 2.4e-05 24.1 0.0 7.5e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.24 001025533.1_16126001_3 - 0.00074 19.1 0.5 0.0064 16.1 0.0 2.5 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_5 PF07728.12 001025533.1_16126001_3 - 0.0016 18.3 0.0 0.0046 16.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase_C PF13335.4 001025533.1_16126001_3 - 0.035 14.6 0.3 0.26 11.8 0.0 2.6 2 1 1 3 3 3 0 Magnesium chelatase, subunit ChlI C-terminal HABP4_PAI-RBP1 PF04774.13 001025533.1_16126001_3 - 1.7 9.4 5.3 24 5.6 0.2 2.5 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family Ribonuc_L-PSP PF01042.19 001012315.2_16123001_3 - 3.2e-38 130.3 0.6 4.1e-38 130.0 0.6 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP RRM_1 PF00076.20 137312.1_16123120_3 - 1.2e-33 114.6 0.0 3e-16 58.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 137312.1_16123120_3 - 1.8e-18 66.3 0.0 1.7e-10 40.7 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 137312.1_16123120_3 - 0.0012 18.7 0.0 0.072 12.9 0.0 2.6 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif CBFNT PF08143.9 137312.1_16123120_3 - 0.0017 19.6 2.1 0.0017 19.6 0.3 2.0 2 0 0 2 2 2 1 CBFNT (NUC161) domain B12-binding PF02310.17 137312.1_16123120_3 - 0.085 12.8 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 B12 binding domain RRM_3 PF08777.9 137312.1_16123120_3 - 0.13 12.2 0.0 6.1 6.8 0.0 2.5 2 0 0 2 2 2 0 RNA binding motif Fer4_3 PF12798.5 137312.1_16123120_3 - 0.99 10.4 5.4 1 10.3 0.8 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain TGF_beta PF00019.18 001279581.1_37525001_3 - 6.6e-09 36.5 8.3 6.6e-09 36.5 8.3 1.9 2 0 0 2 2 2 1 Transforming growth factor beta like domain IRK PF01007.18 205370.1_23525001_2 - 2.1e-156 519.9 1.7 2.7e-156 519.5 1.7 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel IRK_N PF08466.8 205370.1_23525001_2 - 6.2e-26 90.1 1.3 6.2e-26 90.1 1.3 1.9 2 0 0 2 2 2 1 Inward rectifier potassium channel N-terminal Ion_trans_2 PF07885.14 205370.1_23525001_2 - 0.00087 19.1 4.6 0.00087 19.1 4.6 2.5 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.29 205370.1_23525001_2 - 0.0029 16.8 4.6 0.0053 15.9 4.6 1.4 1 0 0 1 1 1 1 Ion transport protein p450 PF00067.20 205147.1_23525001_3 - 1.7e-104 350.1 0.0 2.1e-104 349.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Hormone_2 PF00123.18 001177309.1_23522001_3 - 2.6e-11 43.1 0.2 4.7e-11 42.3 0.2 1.4 1 0 0 1 1 1 1 Peptide hormone 7tm_1 PF00001.19 001271141.1_23523001_3 - 9.6e-48 162.6 21.7 1.8e-47 161.7 21.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001271141.1_23523001_3 - 5e-09 35.8 22.5 7e-09 35.3 22.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Arf PF00025.19 001017827.2_16123001_1 - 1.1e-69 233.2 0.0 1.4e-69 232.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001017827.2_16123001_1 - 7.1e-14 51.5 0.0 9.4e-14 51.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 001017827.2_16123001_1 - 1.2e-13 50.8 0.4 4.3e-08 32.6 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.11 001017827.2_16123001_1 - 5e-13 49.2 0.0 7.3e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001017827.2_16123001_1 - 1.5e-12 47.3 0.0 1.9e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.10 001017827.2_16123001_1 - 1.4e-11 44.1 0.0 1.9e-11 43.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001017827.2_16123001_1 - 7e-07 29.2 0.0 1e-06 28.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001017827.2_16123001_1 - 0.00064 19.2 0.0 0.0055 16.1 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA PF00004.27 001017827.2_16123001_1 - 0.0034 17.7 0.0 0.0056 17.0 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.7 001017827.2_16123001_1 - 0.051 13.2 0.0 0.092 12.4 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.4 001017827.2_16123001_1 - 0.052 13.9 0.0 0.09 13.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain Hormone_1 PF00103.18 001279792.2_37523001_1 - 3.5e-24 85.6 2.6 8.4e-24 84.4 2.6 1.5 1 1 0 1 1 1 1 Somatotropin hormone family DUF3741 PF12552.6 001279792.2_37523001_1 - 0.029 14.2 2.2 2.2 8.2 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3741) Transthyretin PF00576.19 001005598.2_16122001_3 - 3e-21 76.1 0.1 4.5e-21 75.5 0.1 1.2 1 0 0 1 1 1 1 HIUase/Transthyretin family Ras PF00071.20 201495.1_16125001_3 - 1.4e-59 200.2 0.1 2e-59 199.7 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 201495.1_16125001_3 - 4.6e-31 107.4 0.0 7.3e-31 106.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 201495.1_16125001_3 - 2.1e-11 43.5 0.0 3.3e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 201495.1_16125001_3 - 0.00057 19.8 0.0 0.00091 19.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 201495.1_16125001_3 - 0.0012 18.3 0.0 0.013 14.9 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 201495.1_16125001_3 - 0.01 15.7 0.0 5 6.9 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 201495.1_16125001_3 - 0.022 14.0 0.0 0.032 13.5 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Bcl-2 PF00452.17 001030253.2_16123001_2 - 1.5e-32 112.0 0.2 3.6e-32 110.8 0.2 1.6 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family BH4 PF02180.15 001030253.2_16123001_2 - 8.8e-10 38.0 1.1 1.7e-09 37.1 1.1 1.4 1 0 0 1 1 1 1 Bcl-2 homology region 4 Bcl-2_3 PF15286.4 001030253.2_16123001_2 - 0.016 15.8 0.0 0.029 14.9 0.0 1.4 1 0 0 1 1 1 0 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like Laminin_G_3 PF13385.4 001278805.1_16129001_1 - 5.9e-21 75.1 0.0 1.1e-20 74.2 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Sushi PF00084.18 001278805.1_16129001_1 - 1.2e-11 44.9 54.9 9.7e-07 29.2 3.0 9.0 7 2 1 8 8 8 4 Sushi repeat (SCR repeat) Peptidase_M43 PF05572.11 001278805.1_16129001_1 - 6.5e-09 35.7 0.4 6.5e-09 35.7 0.4 2.5 2 1 0 2 2 2 1 Pregnancy-associated plasma protein-A DUF4215 PF13948.4 001278805.1_16129001_1 - 6.1e-06 26.4 2.3 6.1e-06 26.4 2.3 7.2 9 1 1 10 10 10 1 Domain of unknown function (DUF4215) Notch PF00066.15 001278805.1_16129001_1 - 2.8e-05 24.4 54.3 0.0013 19.1 11.1 6.3 4 1 0 4 4 4 3 LNR domain Reprolysin_3 PF13582.4 001278805.1_16129001_1 - 0.00085 19.7 0.2 0.0017 18.7 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001278805.1_16129001_1 - 0.059 12.9 0.1 0.18 11.3 0.1 1.8 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.22 001278805.1_16129001_1 - 0.14 11.9 0.1 0.4 10.4 0.1 1.8 1 0 0 1 1 1 0 Matrixin Laminin_G_1 PF00054.21 001278805.1_16129001_1 - 0.17 11.9 0.0 0.35 11.0 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain fn3 PF00041.19 001278805.1_16129001_1 - 0.19 12.0 0.4 4.6 7.5 0.0 2.8 3 0 0 3 3 3 0 Fibronectin type III domain RHD_DNA_bind PF00554.20 001353873.1_16124001_3 - 6e-68 227.9 0.0 9.3e-68 227.3 0.0 1.3 1 0 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.3 001353873.1_16124001_3 - 1.7e-41 140.3 0.3 3.6e-41 139.2 0.0 1.7 2 0 0 2 2 2 1 Rel homology dimerisation domain Ist1 PF03398.12 001353873.1_16124001_3 - 0.016 15.0 0.1 0.026 14.3 0.1 1.2 1 0 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway BAF1_ABF1 PF04684.11 001353873.1_16124001_3 - 0.59 8.9 3.2 0.88 8.3 3.2 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Carb_anhydrase PF00194.19 001037121.1_16123001_2 - 1.5e-63 214.6 0.1 1.7e-63 214.4 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Somatostatin PF03002.13 183070.1_16122001_3 - 1.1e-11 44.4 8.4 1.1e-11 44.4 8.4 1.8 2 0 0 2 2 2 1 Somatostatin/Cortistatin family PKD_channel PF08016.10 001002310.1_16127001_3 - 1.2e-152 508.4 10.4 1.2e-152 508.4 10.4 1.9 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.29 001002310.1_16127001_3 - 1e-22 80.5 21.8 1e-22 80.5 21.8 2.1 2 0 0 2 2 2 1 Ion transport protein EF-hand_1 PF00036.30 001002310.1_16127001_3 - 1.7e-05 23.9 0.6 0.023 14.1 0.3 3.5 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.4 001002310.1_16127001_3 - 0.0088 15.8 0.2 0.2 11.6 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.4 001002310.1_16127001_3 - 0.022 15.1 0.5 0.26 11.7 0.1 2.5 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_8 PF13833.4 001002310.1_16127001_3 - 0.04 13.5 0.1 0.66 9.7 0.1 2.4 2 0 0 2 2 2 0 EF-hand domain pair DUF21 PF01595.18 001002310.1_16127001_3 - 0.044 13.4 0.9 0.26 10.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF21 SWIRM-assoc_1 PF16495.3 001002310.1_16127001_3 - 2.8 8.0 8.7 0.75 9.8 0.4 3.1 3 0 0 3 3 3 0 SWIRM-associated region 1 Pkinase PF00069.23 001031841.3_16127001_2 - 3.2e-61 206.9 0.3 4.9e-61 206.3 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001031841.3_16127001_2 - 2.2e-34 118.8 0.2 3.7e-34 118.1 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.17 001031841.3_16127001_2 - 4.6e-18 65.5 0.2 1.1e-17 64.2 0.2 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain Kinase-like PF14531.4 001031841.3_16127001_2 - 5.7e-05 22.4 0.0 0.00012 21.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Ras PF00071.20 001030257.1_16123001_2 - 5.3e-55 185.3 0.1 1.2e-54 184.2 0.0 1.6 2 0 0 2 2 2 1 Ras family Roc PF08477.11 001030257.1_16123001_2 - 4.1e-30 104.4 0.1 1.1e-29 103.0 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001030257.1_16123001_2 - 2.2e-10 40.1 0.0 3.2e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001030257.1_16123001_2 - 0.0015 18.5 0.0 0.0027 17.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001030257.1_16123001_2 - 0.0022 17.8 0.2 0.65 9.7 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001030257.1_16123001_2 - 0.0022 17.4 0.0 0.0041 16.6 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain COMM_domain PF07258.12 001008734.2_16122001_2 - 2.6e-18 65.8 0.1 9.7e-18 63.9 0.0 1.9 2 0 0 2 2 2 1 COMM domain TBCC_N PF16752.3 001008734.2_16122001_2 - 0.026 14.8 0.1 0.074 13.3 0.0 1.8 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain SIX1_SD PF16878.3 131720.1_16126001_3 - 2.7e-42 143.7 0.0 5.8e-42 142.6 0.0 1.6 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeobox PF00046.27 131720.1_16126001_3 - 2.4e-13 49.5 0.5 4.9e-13 48.5 0.5 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 131720.1_16126001_3 - 3e-09 36.5 0.4 7e-09 35.3 0.4 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.6 131720.1_16126001_3 - 0.1 11.9 0.1 0.25 10.7 0.1 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Ras PF00071.20 213365.1_16125001_3 - 1e-56 190.9 0.2 1.5e-56 190.3 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 213365.1_16125001_3 - 6.7e-35 119.8 0.1 1e-34 119.2 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 213365.1_16125001_3 - 2.4e-13 49.8 0.1 3.4e-13 49.3 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 213365.1_16125001_3 - 0.00039 19.8 0.0 0.00068 19.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF258 PF03193.14 213365.1_16125001_3 - 0.00044 20.0 0.1 0.24 11.1 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 213365.1_16125001_3 - 0.0013 18.7 0.1 0.0021 18.0 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 213365.1_16125001_3 - 0.0015 17.9 0.1 0.0037 16.7 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 213365.1_16125001_3 - 0.0099 15.1 0.1 0.014 14.6 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.16 213365.1_16125001_3 - 0.11 11.9 0.1 0.98 8.8 0.1 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B 7tm_1 PF00001.19 001099445.2_16126001_1 - 6.1e-32 110.8 15.7 6.1e-32 110.8 15.7 2.2 2 0 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) Pkinase_Tyr PF07714.15 181662.2_16129001_2 - 7e-103 343.3 0.0 9.9e-103 342.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 181662.2_16129001_2 - 7.4e-44 149.9 0.0 1.5e-43 148.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Cadherin PF00028.15 181662.2_16129001_2 - 8.7e-12 45.2 1.9 2.8e-06 27.5 0.0 4.4 4 0 0 4 4 4 1 Cadherin domain RIO1 PF01163.20 181662.2_16129001_2 - 0.13 11.8 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 RIO1 family PsbL PF02419.15 181662.2_16129001_2 - 4.8 7.1 5.5 1.6 8.6 0.5 2.5 2 0 0 2 2 2 0 PsbL protein Sulfotransfer_1 PF00685.25 001076656.1_16124001_3 - 1.1e-72 244.6 0.2 1.4e-72 244.2 0.2 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001076656.1_16124001_3 - 9.9e-08 32.5 0.0 0.00049 20.4 0.0 2.1 1 1 1 2 2 2 2 Sulfotransferase family Ank_2 PF12796.5 001126399.1_16125001_1 - 2e-16 60.2 1.5 1.3e-08 35.2 0.2 3.4 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ion_trans PF00520.29 001126399.1_16125001_1 - 1.7e-12 47.0 8.4 2e-12 46.7 7.7 1.5 1 1 0 1 1 1 1 Ion transport protein Ank_5 PF13857.4 001126399.1_16125001_1 - 1.7e-09 37.6 0.0 0.0057 16.9 0.0 4.2 3 1 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 001126399.1_16125001_1 - 1.9e-08 33.8 0.0 0.0022 18.2 0.0 5.4 6 0 0 6 6 6 1 Ankyrin repeat Ank PF00023.28 001126399.1_16125001_1 - 1.3e-07 31.6 0.2 0.002 18.4 0.0 4.7 5 0 0 5 5 5 1 Ankyrin repeat Ank_4 PF13637.4 001126399.1_16125001_1 - 9.1e-05 22.8 0.0 0.36 11.3 0.0 4.4 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Orai-1 PF07856.10 001126399.1_16125001_1 - 0.26 10.8 0.0 0.26 10.8 0.0 2.9 3 1 0 3 3 3 0 Mediator of CRAC channel activity Peptidase_M14 PF00246.22 214810.2_16129001_1 - 1.8e-82 277.3 0.0 2.3e-82 277.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.4 214810.2_16129001_1 - 1.1e-16 60.7 0.0 1.9e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.4 214810.2_16129001_1 - 9.9e-07 28.5 0.0 2e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 CarboxypepD_reg-like domain Dimer_Tnp_hAT PF05699.12 214810.2_16129001_1 - 0.06 13.0 4.6 0.069 12.8 0.2 2.5 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region PEGA PF08308.9 214810.2_16129001_1 - 0.065 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 PEGA domain AstE_AspA PF04952.12 214810.2_16129001_1 - 0.14 11.0 0.2 0.24 10.3 0.2 1.2 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family Ras PF00071.20 001020630.1_16123001_2 - 4.4e-58 195.3 0.2 5.8e-58 194.9 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001020630.1_16123001_2 - 3e-34 117.7 0.1 4.4e-34 117.2 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001020630.1_16123001_2 - 3.5e-15 55.7 0.0 4.7e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001020630.1_16123001_2 - 9e-07 28.9 0.0 1.3e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001020630.1_16123001_2 - 1.2e-05 24.8 0.0 0.00071 19.0 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001020630.1_16123001_2 - 1.3e-05 24.5 0.1 1.7e-05 24.1 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001020630.1_16123001_2 - 0.0001 21.7 0.0 0.00013 21.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.4 001020630.1_16123001_2 - 0.0017 18.6 0.0 0.0027 18.0 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.14 001020630.1_16123001_2 - 0.0021 17.9 0.0 0.7 9.6 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_14 PF13173.4 001020630.1_16123001_2 - 0.012 15.5 0.1 0.021 14.7 0.1 1.4 1 1 0 1 1 1 0 AAA domain Septin PF00735.16 001020630.1_16123001_2 - 0.043 12.9 0.0 0.064 12.4 0.0 1.2 1 0 0 1 1 1 0 Septin TniB PF05621.9 001020630.1_16123001_2 - 0.073 12.1 0.1 1.8 7.5 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein AAA_24 PF13479.4 001020630.1_16123001_2 - 0.074 12.6 0.0 0.11 12.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.4 001020630.1_16123001_2 - 0.092 12.9 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.10 001020630.1_16123001_2 - 0.11 12.2 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA PF00004.27 001020630.1_16123001_2 - 0.13 12.5 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.7 001020630.1_16123001_2 - 0.17 11.5 0.0 0.3 10.7 0.0 1.4 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Nodulin_late PF07127.9 001020630.1_16123001_3 - 0.14 12.4 0.2 0.31 11.3 0.2 1.6 1 0 0 1 1 1 0 Late nodulin protein Bcl-2 PF00452.17 131562.2_16124001_3 - 2.8e-27 95.1 0.2 4.8e-27 94.3 0.2 1.4 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family Peptidase_C14 PF00656.20 131505.2_16124001_1 - 3.4e-44 151.5 0.0 6.8e-44 150.5 0.0 1.5 1 0 0 1 1 1 1 Caspase domain PYRIN PF02758.14 131505.2_16124001_1 - 2.7e-13 49.8 0.0 2.7e-13 49.8 0.0 3.2 3 0 0 3 3 3 1 PAAD/DAPIN/Pyrin domain Suc_Fer-like PF06999.10 131505.2_16124001_1 - 0.0067 16.2 0.3 0.018 14.8 0.1 1.7 2 0 0 2 2 2 1 Sucrase/ferredoxin-like PAP2 PF01569.19 001163806.1_16125001_2 - 2.4e-15 56.4 4.6 2.4e-15 56.4 4.6 1.7 2 0 0 2 2 2 1 PAP2 superfamily zf-C2H2 PF00096.24 131856.3_16125001_2 - 5.3e-13 48.5 27.9 6.9e-05 22.9 4.1 4.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 131856.3_16125001_2 - 1e-07 31.9 15.8 2e-06 27.9 4.9 4.8 6 0 0 6 6 6 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 131856.3_16125001_2 - 0.0029 18.2 33.5 0.015 16.0 3.5 4.2 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.5 131856.3_16125001_2 - 1.5 9.2 9.6 0.59 10.5 1.3 3.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type EF-hand_7 PF13499.4 199964.1_16124001_1 - 2.1e-17 63.2 3.0 4.2e-08 33.4 0.1 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.30 199964.1_16124001_1 - 1.2e-14 52.6 0.4 7.4e-06 25.0 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.4 199964.1_16124001_1 - 2.1e-14 52.0 0.1 0.0002 20.9 0.1 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.4 199964.1_16124001_1 - 7.9e-11 41.4 0.2 1.3e-06 27.9 0.1 2.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 199964.1_16124001_1 - 1.2e-10 40.2 0.3 0.003 16.9 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.5 199964.1_16124001_1 - 0.00062 19.6 0.4 0.28 11.0 0.0 2.5 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 199964.1_16124001_1 - 0.0041 17.3 1.2 0.54 10.5 0.0 2.4 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Ras PF00071.20 001029970.2_16125001_1 - 1.9e-46 157.5 0.2 2.7e-46 157.0 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001029970.2_16125001_1 - 2.9e-27 95.2 0.0 4.9e-27 94.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001029970.2_16125001_1 - 4.9e-10 39.0 0.0 7.3e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 001029970.2_16125001_1 - 0.0083 15.9 0.0 0.83 9.4 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 001029970.2_16125001_1 - 0.0098 15.8 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001029970.2_16125001_1 - 0.14 11.6 0.0 0.24 10.8 0.0 1.4 1 1 0 1 1 1 0 Ferrous iron transport protein B Cullin PF00888.20 213495.1_16126001_2 - 2.1e-200 667.3 16.3 2.1e-200 667.3 16.3 1.5 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.7 213495.1_16126001_2 - 7.7e-28 96.2 4.8 8.5e-28 96.1 3.0 2.1 2 0 0 2 2 2 1 Cullin protein neddylation domain Laminin_G_2 PF02210.22 001281991.1_16129001_3 - 1.2e-92 306.9 5.3 2.7e-24 86.0 1.3 4.3 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.21 001281991.1_16129001_3 - 1.6e-64 215.8 0.1 4.4e-19 68.9 0.1 4.5 4 0 0 4 4 4 4 Laminin G domain F5_F8_type_C PF00754.23 001281991.1_16129001_3 - 2.9e-30 104.8 1.2 1.1e-29 103.0 0.6 2.4 2 0 0 2 2 2 1 F5/8 type C domain Laminin_G_3 PF13385.4 001281991.1_16129001_3 - 8.9e-08 32.3 4.8 0.043 13.8 0.0 4.3 5 0 0 5 5 5 2 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 001281991.1_16129001_3 - 0.00018 21.6 25.6 0.00049 20.2 9.6 3.4 3 0 0 3 3 3 2 EGF-like domain COLFI PF01410.16 001281991.1_16129001_3 - 0.0019 17.4 0.2 0.0064 15.7 0.1 1.9 2 0 0 2 2 2 1 Fibrillar collagen C-terminal domain Syndecan PF01034.18 001281991.1_16129001_3 - 0.092 12.5 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain hEGF PF12661.5 001281991.1_16129001_3 - 0.26 11.9 32.6 0.046 14.3 4.0 3.8 4 0 0 4 4 4 0 Human growth factor-like EGF zf-C4 PF00105.16 001161333.1_16128001_2 - 7.3e-28 96.7 16.2 2e-27 95.3 16.2 1.8 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001161333.1_16128001_2 - 1.7e-14 53.8 0.0 4.8e-14 52.3 0.0 1.6 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor FAM60A PF15396.4 198825.4_16125001_1 - 2.5e-74 249.7 10.9 1.8e-72 243.7 10.9 2.1 1 1 0 1 1 1 1 Protein Family FAM60A Ras PF00071.20 001002178.1_16123001_3 - 1.8e-58 196.6 0.2 2.3e-58 196.2 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001002178.1_16123001_3 - 2.4e-32 111.5 0.0 3.9e-32 110.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001002178.1_16123001_3 - 4.7e-13 48.8 0.1 8e-13 48.1 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001002178.1_16123001_3 - 1.9e-06 27.8 0.0 3e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001002178.1_16123001_3 - 3.8e-05 23.5 0.0 0.0058 16.4 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001002178.1_16123001_3 - 6.4e-05 22.4 0.1 0.0014 18.1 0.1 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001002178.1_16123001_3 - 8.6e-05 21.9 0.0 0.00012 21.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.15 001002178.1_16123001_3 - 0.005 16.5 0.4 0.098 12.3 0.1 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein cobW PF02492.17 001002178.1_16123001_3 - 0.0061 16.0 0.1 0.021 14.3 0.0 1.7 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.4 001002178.1_16123001_3 - 0.014 15.5 0.0 0.033 14.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.7 001002178.1_16123001_3 - 0.02 14.5 0.1 0.32 10.6 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Septin PF00735.16 001002178.1_16123001_3 - 0.022 13.8 0.2 0.054 12.6 0.1 1.7 2 0 0 2 2 2 0 Septin AAA_16 PF13191.4 001002178.1_16123001_3 - 0.053 13.8 0.0 0.1 12.8 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain Glyco_hydro_75 PF07335.9 001002178.1_16123001_3 - 0.056 13.6 0.0 0.094 12.9 0.0 1.3 1 0 0 1 1 1 0 Fungal chitosanase of glycosyl hydrolase group 75 ATPase_2 PF01637.16 001002178.1_16123001_3 - 0.058 13.2 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_24 PF13479.4 001002178.1_16123001_3 - 0.059 12.9 0.0 0.098 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.8 001002178.1_16123001_3 - 0.059 12.7 0.0 0.09 12.1 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit NTPase_1 PF03266.13 001002178.1_16123001_3 - 0.1 12.4 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 NTPase FAM60A PF15396.4 001353917.1_16125001_1 - 1.7e-78 263.3 11.4 2.3e-78 262.9 11.4 1.2 1 0 0 1 1 1 1 Protein Family FAM60A LRR_8 PF13855.4 212812.1_16125001_1 - 3e-31 106.8 55.3 3.7e-14 52.1 11.6 8.8 7 2 1 8 8 8 6 Leucine rich repeat TIR PF01582.18 212812.1_16125001_1 - 6.9e-24 84.5 0.6 1.1e-23 83.8 0.6 1.3 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.5 212812.1_16125001_1 - 1.8e-15 56.6 55.4 0.00036 20.7 6.7 8.6 7 1 1 8 8 8 6 Leucine Rich repeats (2 copies) TIR_2 PF13676.4 212812.1_16125001_1 - 8.3e-12 45.2 0.1 1.6e-11 44.3 0.1 1.5 1 0 0 1 1 1 1 TIR domain LRR_9 PF14580.4 212812.1_16125001_1 - 3.2e-05 23.4 18.5 0.0014 18.0 0.3 3.7 2 2 1 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.31 212812.1_16125001_1 - 0.015 15.6 39.9 3 8.5 3.2 11.2 9 1 1 10 10 10 0 Leucine Rich Repeat DUF1863 PF08937.9 212812.1_16125001_1 - 0.18 12.0 0.3 0.61 10.3 0.3 1.9 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) LRR_6 PF13516.4 212812.1_16125001_1 - 2 8.6 38.6 3.8 7.7 0.1 9.3 10 0 0 10 10 10 0 Leucine Rich repeat Arm PF00514.21 001002210.1_16124001_1 - 5.8e-38 127.7 17.9 7.3e-10 38.4 0.0 8.6 9 0 0 9 9 9 6 Armadillo/beta-catenin-like repeat HEAT PF02985.20 001002210.1_16124001_1 - 1.2e-17 62.3 6.6 0.026 14.6 0.0 7.7 7 0 0 7 7 7 6 HEAT repeat HEAT_2 PF13646.4 001002210.1_16124001_1 - 1.5e-15 57.2 10.6 0.00064 19.9 0.1 5.3 2 2 4 6 6 6 5 HEAT repeats Cnd1 PF12717.5 001002210.1_16124001_1 - 3.9e-15 56.1 0.1 0.0046 16.8 0.0 4.9 1 1 3 4 4 4 4 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 001002210.1_16124001_1 - 1.3e-12 47.7 13.6 0.0012 19.2 0.9 6.5 5 1 1 6 6 6 4 HEAT-like repeat CHASE6_C PF17150.2 001002210.1_16124001_1 - 1.8e-07 31.6 0.2 7.1 7.2 0.0 6.8 7 0 0 7 7 6 1 C-terminal domain of two-partite extracellular sensor domain Adaptin_N PF01602.18 001002210.1_16124001_1 - 1.1e-06 27.4 3.9 0.0017 16.9 0.5 4.1 1 1 2 4 4 4 3 Adaptin N terminal region Proteasom_PSMB PF10508.7 001002210.1_16124001_1 - 1e-05 24.2 2.0 0.0014 17.1 0.3 2.8 1 1 1 2 2 2 2 Proteasome non-ATPase 26S subunit DNA_alkylation PF08713.9 001002210.1_16124001_1 - 1.2e-05 25.0 0.1 1.7 8.2 0.0 4.1 2 1 0 3 3 3 2 DNA alkylation repair enzyme RICTOR_V PF14668.4 001002210.1_16124001_1 - 0.00056 20.0 0.1 1.2 9.3 0.0 4.1 3 1 1 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_C PF11698.6 001002210.1_16124001_1 - 0.0028 17.6 0.4 6.3 6.8 0.0 4.1 4 0 0 4 4 4 1 V-ATPase subunit H HEAT_PBS PF03130.14 001002210.1_16124001_1 - 0.0064 16.9 2.8 12 6.8 0.1 4.8 5 0 0 5 5 4 0 PBS lyase HEAT-like repeat RTP1_C1 PF10363.7 001002210.1_16124001_1 - 0.11 12.6 0.4 3.3 7.8 0.1 3.3 4 0 0 4 4 3 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF3731 PF12531.6 001002210.1_16124001_1 - 0.79 9.3 3.6 15 5.2 0.1 3.5 2 1 1 4 4 4 0 DNA-K related protein LRR_8 PF13855.4 001130594.1_16127001_2 - 2.4e-63 209.6 92.8 1.3e-08 34.3 0.2 15.2 10 4 5 15 15 15 13 Leucine rich repeat LRR_4 PF12799.5 001130594.1_16127001_2 - 1.1e-29 101.7 97.2 7e-05 23.0 0.6 15.2 8 3 11 20 20 20 15 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001130594.1_16127001_2 - 5.8e-09 35.8 15.1 0.047 13.5 0.0 7.8 6 2 1 7 7 7 3 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001130594.1_16127001_2 - 1.5e-07 31.0 26.3 0.047 13.1 0.1 7.5 3 2 3 7 7 7 3 Leucine-rich repeat TIR PF01582.18 001130594.1_16127001_2 - 3.2e-07 30.2 0.1 9.7e-07 28.6 0.1 1.8 1 1 0 1 1 1 1 TIR domain LRR_1 PF00560.31 001130594.1_16127001_2 - 0.0002 21.2 85.2 1.6 9.4 0.9 21.0 22 2 1 23 23 23 4 Leucine Rich Repeat LRR_6 PF13516.4 001130594.1_16127001_2 - 0.31 11.1 0.0 0.31 11.1 0.0 18.8 21 0 0 21 21 21 0 Leucine Rich repeat PTEN_C2 PF10409.7 001025458.1_16125001_3 - 1.1e-25 89.9 0.0 1.9e-25 89.1 0.0 1.4 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Ion_trans PF00520.29 001025458.1_16125001_3 - 1.1e-09 37.8 8.4 1.6e-09 37.3 8.4 1.2 1 0 0 1 1 1 1 Ion transport protein DSPc PF00782.18 001025458.1_16125001_3 - 3.9e-08 33.0 0.0 8.2e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PKD_channel PF08016.10 001025458.1_16125001_3 - 0.0001 21.0 1.1 0.00015 20.4 1.1 1.3 1 0 0 1 1 1 1 Polycystin cation channel PTPlike_phytase PF14566.4 001025458.1_16125001_3 - 0.0012 18.9 0.0 0.0024 17.9 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.25 001025458.1_16125001_3 - 0.0043 16.5 0.0 0.0091 15.4 0.0 1.6 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 001025458.1_16125001_3 - 0.073 12.9 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Pox_A14 PF05767.10 001025458.1_16125001_3 - 1.3 9.1 9.4 3.1 7.9 1.6 2.4 1 1 1 2 2 2 0 Poxvirus virion envelope protein A14 SOCS_box PF07525.14 001252630.1_16122001_3 - 3.7e-06 27.0 0.0 6.7e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 SOCS box SH2 PF00017.22 001252630.1_16122001_3 - 6.6e-05 22.8 0.0 0.00011 22.1 0.0 1.3 1 0 0 1 1 1 1 SH2 domain Gelsolin PF00626.20 213090.2_16126001_1 - 3.4e-89 292.7 0.0 1.6e-15 56.6 0.0 6.5 6 0 0 6 6 6 6 Gelsolin repeat RelB PF04221.10 213090.2_16126001_1 - 0.084 12.7 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 RelB antitoxin Ras PF00071.20 001002555.1_16123001_1 - 2.8e-63 212.2 0.1 3.5e-63 211.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001002555.1_16123001_1 - 5.7e-35 120.0 0.1 9.1e-35 119.4 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001002555.1_16123001_1 - 1.1e-12 47.6 0.1 1.5e-12 47.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001002555.1_16123001_1 - 7.9e-07 29.0 0.1 1.2e-06 28.4 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 001002555.1_16123001_1 - 0.00023 21.3 0.0 0.002 18.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.14 001002555.1_16123001_1 - 0.00034 20.4 0.5 0.042 13.6 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001002555.1_16123001_1 - 0.00038 19.9 0.1 0.0013 18.2 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.4 001002555.1_16123001_1 - 0.0072 16.6 0.1 0.026 14.8 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain Gtr1_RagA PF04670.10 001002555.1_16123001_1 - 0.0091 15.2 0.1 0.016 14.5 0.1 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region ABC_tran PF00005.25 001002555.1_16123001_1 - 0.047 14.1 0.1 0.087 13.2 0.1 1.5 1 1 0 1 1 1 0 ABC transporter SRPRB PF09439.8 001002555.1_16123001_1 - 0.054 12.8 0.0 0.12 11.7 0.0 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.7 001002555.1_16123001_1 - 0.067 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.16 001002555.1_16123001_1 - 0.084 12.3 0.1 0.21 11.0 0.1 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_14 PF13173.4 001002555.1_16123001_1 - 0.098 12.6 0.1 0.25 11.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain MNSV_P7B PF06692.9 001002555.1_16123001_1 - 0.25 11.2 5.1 6.3 6.7 0.2 2.5 2 0 0 2 2 2 0 Melon necrotic spot virus P7B protein EGF PF00008.25 130944.1_16128001_2 - 3.9e-41 138.8 145.7 2.9e-09 36.9 9.1 9.8 9 1 0 9 9 9 7 EGF-like domain hEGF PF12661.5 130944.1_16128001_2 - 5.6e-27 93.3 115.6 6.9e-05 23.2 8.2 10.2 9 0 0 9 9 9 7 Human growth factor-like EGF DSL PF01414.17 130944.1_16128001_2 - 2e-24 85.4 4.8 2e-24 85.4 4.8 7.6 4 2 4 8 8 8 1 Delta serrate ligand EGF_2 PF07974.11 130944.1_16128001_2 - 4.2e-11 42.9 164.7 0.013 15.8 15.3 10.0 10 0 0 10 10 10 8 EGF-like domain EGF_3 PF12947.5 130944.1_16128001_2 - 0.00014 21.8 10.1 0.00014 21.8 10.1 8.7 7 2 0 7 7 7 3 EGF domain EGF_CA PF07645.13 130944.1_16128001_2 - 0.00024 21.1 9.4 0.00024 21.1 9.4 10.2 3 3 7 10 10 10 4 Calcium-binding EGF domain RRM_1 PF00076.20 200259.1_16124001_3 - 4.2e-12 45.6 0.0 1.3e-11 44.0 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_S9 PF00326.19 001145616.1_16125001_3 - 7.1e-33 113.7 0.0 9.7e-33 113.3 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.13 001145616.1_16125001_3 - 6.8e-18 64.5 0.2 9.3e-18 64.1 0.2 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Hydrolase_4 PF12146.6 001145616.1_16125001_3 - 0.00038 19.6 0.0 0.00069 18.8 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ras PF00071.20 001328529.1_16129001_1 - 2.4e-57 192.9 0.5 3.6e-57 192.4 0.5 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001328529.1_16129001_1 - 1.4e-34 118.8 0.2 2.1e-34 118.2 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001328529.1_16129001_1 - 6.4e-14 51.7 0.1 9.1e-14 51.1 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001328529.1_16129001_1 - 0.00013 21.4 0.1 0.00026 20.4 0.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.8 001328529.1_16129001_1 - 0.00019 20.8 0.1 0.00031 20.1 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 001328529.1_16129001_1 - 0.0011 19.0 0.1 0.0017 18.3 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001328529.1_16129001_1 - 0.0052 16.0 0.2 0.0076 15.5 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.14 001328529.1_16129001_1 - 0.014 15.2 0.1 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 FeoB_N PF02421.16 001328529.1_16129001_1 - 0.024 14.0 0.2 0.12 11.8 0.2 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B SQHop_cyclase_C PF13243.4 001083567.1_16126001_2 - 2.1e-58 197.8 0.0 7.7e-52 176.2 0.0 2.3 2 0 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.4 001083567.1_16126001_2 - 1.5e-48 165.3 0.0 7.2e-43 146.6 0.0 3.6 4 0 0 4 4 4 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.19 001083567.1_16126001_2 - 5e-40 134.8 9.9 1.1e-10 41.0 0.1 5.7 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.8 001083567.1_16126001_2 - 0.00015 21.0 0.1 6 6.0 0.0 4.1 4 0 0 4 4 4 3 Pectic acid lyase A2M_comp PF07678.12 001083567.1_16126001_2 - 0.025 13.9 0.0 1.6 8.0 0.0 3.1 2 1 0 2 2 2 0 A-macroglobulin complement component FF PF01846.17 198356.1_16127001_3 - 2.2e-48 162.1 18.3 4.3e-17 61.9 0.1 6.0 5 0 0 5 5 5 5 FF domain WW PF00397.24 198356.1_16127001_3 - 1e-19 70.0 15.6 4.8e-10 39.1 2.8 2.6 2 0 0 2 2 2 2 WW domain LUD_dom PF02589.13 198356.1_16127001_3 - 8.7 5.9 6.9 0.65 9.6 0.7 2.2 3 0 0 3 3 3 0 LUD domain Actin PF00022.17 001079481.1_23523001_1 - 4.9e-150 499.5 0.0 1.5e-149 498.0 0.0 1.6 1 1 0 1 1 1 1 Actin BK_channel_a PF03493.16 204224.1_23528001_1 - 3.9e-32 110.3 0.1 9.9e-32 109.0 0.1 1.8 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.29 204224.1_23528001_1 - 5.9e-18 64.8 19.6 1.4e-17 63.6 19.6 1.5 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.14 204224.1_23528001_1 - 3e-14 52.6 3.6 3e-14 52.6 3.6 2.6 2 0 0 2 2 2 1 Ion channel TrkA_N PF02254.16 204224.1_23528001_1 - 2.6e-05 24.3 0.1 0.00017 21.7 0.0 2.2 2 0 0 2 2 2 1 TrkA-N domain Lig_chan PF00060.24 204224.1_23528001_1 - 0.05 13.3 3.7 0.27 10.9 1.0 2.7 2 0 0 2 2 2 0 Ligand-gated ion channel SR-25 PF10500.7 204224.1_23528001_1 - 6.4 6.2 13.0 12 5.3 13.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CENP-O PF09496.8 001031099.1_23526001_1 - 1.3e-08 35.0 0.1 1.3e-08 35.0 0.1 1.8 2 0 0 2 2 2 1 Cenp-O kinetochore centromere component DASH_Spc19 PF08287.9 001031099.1_23526001_1 - 0.0046 16.8 6.5 0.0099 15.7 6.5 1.5 1 0 0 1 1 1 1 Spc19 Takusan PF04822.11 001031099.1_23526001_1 - 0.018 14.8 3.4 0.042 13.6 3.4 1.6 1 0 0 1 1 1 0 Takusan Spc7 PF08317.9 001031099.1_23526001_1 - 0.28 9.9 4.5 0.42 9.3 4.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DivIC PF04977.13 001031099.1_23526001_1 - 0.49 10.1 7.8 1.3 8.8 7.8 1.6 1 0 0 1 1 1 0 Septum formation initiator IncA PF04156.12 001031099.1_23526001_1 - 1.6 8.3 5.9 3.4 7.3 5.9 1.4 1 0 0 1 1 1 0 IncA protein DUF4140 PF13600.4 001031099.1_23526001_1 - 7.1 7.0 6.9 13 6.2 6.9 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Cornichon PF03311.12 001033501.1_23522001_1 - 2.1e-34 118.3 6.9 3.4e-33 114.4 6.9 2.0 1 1 0 1 1 1 1 Cornichon protein YqfQ PF14181.4 001033501.1_23522001_3 - 0.82 9.7 13.0 1.8 8.6 1.6 3.1 1 1 2 3 3 3 0 YqfQ-like protein LIM PF00412.20 205413.1_23524001_2 - 3.1e-32 110.4 24.9 1e-17 63.9 2.1 2.3 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 205413.1_23524001_2 - 9.6e-20 70.0 1.9 1.7e-19 69.2 1.9 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 205413.1_23524001_2 - 2e-05 24.2 0.1 5.9e-05 22.7 0.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain SpoIIIAH PF12685.5 205413.1_23524001_2 - 1.9 8.1 5.8 2.6 7.7 5.8 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein KH_1 PF00013.27 201192.1_16125001_3 - 4.1e-49 164.1 15.2 2.8e-18 65.4 0.5 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 201192.1_16125001_3 - 1.5e-13 50.2 8.0 7e-05 22.4 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.4 201192.1_16125001_3 - 3.3e-06 26.8 4.0 0.29 10.9 0.6 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.4 201192.1_16125001_3 - 0.00046 20.1 7.9 0.68 9.9 0.1 3.3 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.3 201192.1_16125001_3 - 0.038 13.9 0.1 0.21 11.5 0.0 2.2 3 0 0 3 3 3 0 KH-like RNA-binding domain 7tm_1 PF00001.19 001044743.1_16123001_1 - 6.7e-67 225.4 8.9 9.5e-67 224.9 8.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001044743.1_16123001_1 - 4.2e-09 36.0 12.8 2.1e-08 33.7 12.8 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001044743.1_16123001_1 - 1.3e-07 31.6 7.8 1.3e-07 31.6 7.8 1.7 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001044743.1_16123001_1 - 2.1e-06 27.1 6.8 2.1e-06 27.1 6.8 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.7 001044743.1_16123001_1 - 3.6e-06 26.4 11.5 5.6e-05 22.5 11.5 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Pkinase PF00069.23 131722.1_16125001_1 - 1.1e-65 221.5 0.0 1.5e-65 221.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 131722.1_16125001_1 - 3.2e-30 105.1 0.0 4.7e-30 104.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 131722.1_16125001_1 - 0.0002 20.6 0.3 0.00031 20.0 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 131722.1_16125001_1 - 0.031 14.0 0.1 0.088 12.6 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF1011 PF06237.10 001002182.1_16125001_3 - 7.1e-44 148.0 6.7 2.6e-43 146.2 6.7 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1011) Myosin_tail_1 PF01576.17 205477.1_23529001_1 - 0 1660.4 311.0 0 1660.1 311.0 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 205477.1_23529001_1 - 0 1019.1 1.5 0 1019.1 1.5 3.9 4 1 1 5 5 5 1 Myosin head (motor domain) Myosin_N PF02736.17 205477.1_23529001_1 - 1.4e-11 43.9 1.7 3.2e-11 42.7 1.7 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.25 205477.1_23529001_1 - 0.00042 19.7 0.1 0.0014 18.1 0.1 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif CC2-LZ PF16516.3 205477.1_23529001_1 - 0.0015 18.7 20.8 0.0015 18.7 20.8 17.1 3 2 9 14 14 14 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator AAA_22 PF13401.4 205477.1_23529001_1 - 0.11 12.6 0.0 0.11 12.6 0.0 6.5 5 2 0 6 6 6 0 AAA domain Reo_sigmaC PF04582.10 205477.1_23529001_1 - 1.9 7.7 70.6 0.27 10.5 2.0 8.3 3 2 5 9 9 9 0 Reovirus sigma C capsid protein 7tm_1 PF00001.19 131084.1_16124001_1 - 9.9e-46 156.0 10.1 1.4e-45 155.5 10.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Rhodopsin_N PF10413.7 131084.1_16124001_1 - 2.6e-24 84.6 4.6 5.9e-24 83.5 4.6 1.7 1 0 0 1 1 1 1 Amino terminal of the G-protein receptor rhodopsin 7TM_GPCR_Srv PF10323.7 131084.1_16124001_1 - 1.2e-09 37.8 15.0 3e-09 36.5 15.0 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 131084.1_16124001_1 - 3e-09 36.5 13.4 4.1e-09 36.1 13.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.7 131084.1_16124001_1 - 1.8e-08 33.9 11.0 4.4e-08 32.7 4.3 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw TAS2R PF05296.11 131084.1_16124001_1 - 0.00013 21.0 4.2 0.0034 16.4 0.7 2.2 2 0 0 2 2 2 2 Taste receptor protein (TAS2R) 7TM_GPCR_Srh PF10318.7 131084.1_16124001_1 - 0.00034 19.6 6.8 0.00034 19.6 6.8 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srh 7TM_GPCR_Srx PF10328.7 131084.1_16124001_1 - 0.0016 17.7 16.3 0.0027 16.9 16.3 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 131084.1_16124001_1 - 0.0021 17.7 11.5 0.0076 15.9 11.5 1.7 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Sru PF10322.7 131084.1_16124001_1 - 0.0026 17.0 4.5 0.0026 17.0 4.5 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Sru DUF92 PF01940.14 131084.1_16124001_1 - 0.041 13.2 0.2 0.041 13.2 0.2 1.9 2 1 0 2 2 2 0 Integral membrane protein DUF92 FA_desaturase PF00487.22 131084.1_16124001_1 - 0.95 9.1 7.0 0.33 10.6 0.5 2.2 2 0 0 2 2 2 0 Fatty acid desaturase Paxillin PF03535.11 204984.1_23525001_3 - 3.3e-91 304.6 23.7 6.6e-91 303.6 23.7 1.5 1 0 0 1 1 1 1 Paxillin family LIM PF00412.20 204984.1_23525001_3 - 9.9e-67 220.9 37.0 4e-18 65.3 2.1 4.2 4 0 0 4 4 4 4 LIM domain Ribosomal_L37e PF01907.17 204984.1_23525001_3 - 0.94 9.6 8.0 21 5.2 0.1 3.9 3 0 0 3 3 3 0 Ribosomal protein L37e HLH PF00010.24 001037681.1_16123001_3 - 3.2e-16 58.9 0.2 6e-16 58.0 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF2856 PF11043.6 001037681.1_16123001_3 - 0.069 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2856) Pkinase PF00069.23 205314.1_23523001_3 - 1.2e-76 257.4 0.0 1.4e-76 257.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 205314.1_23523001_3 - 1.1e-35 123.1 0.0 1.4e-35 122.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 205314.1_23523001_3 - 0.0036 17.1 0.0 0.006 16.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.4 205314.1_23523001_3 - 0.0061 15.8 0.0 0.011 14.9 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.12 205314.1_23523001_3 - 0.049 12.8 0.1 0.16 11.2 0.0 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.9 205314.1_23523001_3 - 0.087 11.7 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Vinculin PF01044.17 205441.1_23527001_3 - 0 1656.3 39.7 4.5e-298 991.6 17.5 2.0 1 1 1 2 2 2 2 Vinculin family CARD PF00619.19 205441.1_23527001_3 - 0.1 12.5 0.7 0.95 9.4 0.1 3.0 3 0 0 3 3 3 0 Caspase recruitment domain Dynactin_p22 PF07426.9 205441.1_23527001_3 - 0.27 10.9 13.0 1.4 8.6 0.0 5.1 5 0 0 5 5 5 0 Dynactin subunit p22 Flavodoxin_1 PF00258.23 205441.1_23527001_3 - 0.27 11.3 2.1 0.47 10.5 0.3 2.5 2 0 0 2 2 2 0 Flavodoxin Hemerythrin PF01814.21 205441.1_23527001_3 - 2.3 8.7 5.2 1.7e+02 2.6 0.2 4.8 3 1 0 3 3 3 0 Hemerythrin HHE cation binding domain SKA2 PF16740.3 205441.1_23527001_3 - 4.9 6.8 26.0 6.9 6.4 2.2 6.5 6 0 0 6 6 6 0 Spindle and kinetochore-associated protein 2 Homeobox PF00046.27 204556.1_23522001_3 - 3.7e-09 36.1 0.1 6.4e-09 35.4 0.1 1.3 1 0 0 1 1 1 1 Homeobox domain Sulfotransfer_2 PF03567.12 001020508.2_16124001_1 - 1.6e-78 264.0 1.1 2.1e-78 263.6 1.1 1.2 1 0 0 1 1 1 1 Sulfotransferase family Vitellogenin_N PF01347.20 001031276.1_23529001_1 - 2.1e-155 518.5 0.0 2.1e-155 518.5 0.0 2.3 2 0 0 2 2 2 1 Lipoprotein amino terminal region DUF1943 PF09172.9 001031276.1_23529001_1 - 5.6e-62 209.7 0.0 5.6e-62 209.7 0.0 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF1943) DUF1944 PF09175.8 001031276.1_23529001_1 - 2.4e-60 203.0 0.0 4.6e-60 202.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1944) VWD PF00094.23 001031276.1_23529001_1 - 8.6e-27 94.2 0.0 2.7e-26 92.6 0.0 2.0 1 0 0 1 1 1 1 von Willebrand factor type D domain HEAT_2 PF13646.4 001031276.1_23529001_1 - 0.00073 19.7 0.0 1.4 9.2 0.0 3.2 2 1 0 2 2 2 2 HEAT repeats Biopterin_H PF00351.19 001001829.1_16124001_3 - 1.3e-169 563.4 0.0 1.5e-169 563.1 0.0 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase Integrin_alpha2 PF08441.10 001013448.1_16129001_2 - 1.1e-123 413.4 3.5 1.5e-123 413.0 3.5 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 001013448.1_16129001_2 - 7e-17 61.1 21.4 3.3e-09 36.6 6.1 3.6 3 0 0 3 3 3 3 FG-GAP repeat VCBS PF13517.4 001013448.1_16129001_2 - 2.6e-09 37.4 7.5 1.5e-08 35.0 4.0 2.7 2 0 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.18 001013448.1_16129001_2 - 0.027 14.3 1.0 0.083 12.8 1.0 1.9 1 0 0 1 1 1 0 Integrin alpha cytoplasmic region LYRIC PF15686.3 001013448.1_16129001_2 - 0.18 11.2 0.0 0.18 11.2 0.0 1.8 2 0 0 2 2 2 0 Lysine-rich CEACAM1 co-isolated protein family DUF4381 PF14316.4 001013448.1_16129001_2 - 0.22 11.6 0.3 0.74 9.9 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Trypsin PF00089.24 205385.1_23522001_2 - 3.2e-79 265.7 6.9 3.7e-79 265.5 6.9 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 205385.1_23522001_2 - 0.00044 21.0 0.1 0.0007 20.4 0.1 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain 7tm_1 PF00001.19 001030606.1_23523001_1 - 1.1e-43 149.3 15.8 1.4e-43 149.0 15.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Rhodopsin_N PF10413.7 001030606.1_23523001_1 - 2.1e-26 91.3 1.7 2.1e-26 91.3 1.7 2.1 2 0 0 2 2 2 1 Amino terminal of the G-protein receptor rhodopsin 7TM_GPCR_Srv PF10323.7 001030606.1_23523001_1 - 1.3e-09 37.7 21.3 1.7e-09 37.3 21.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.7 001030606.1_23523001_1 - 2.3e-09 36.9 18.5 6e-09 35.5 18.5 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.7 001030606.1_23523001_1 - 3.4e-08 33.1 19.0 4.5e-08 32.7 19.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001030606.1_23523001_1 - 0.0055 16.4 17.8 0.037 13.6 17.8 1.9 1 1 0 1 1 1 1 Olfactory receptor TAS2R PF05296.11 001030606.1_23523001_1 - 0.0072 15.3 2.0 0.0072 15.3 2.0 2.1 2 0 0 2 2 2 1 Taste receptor protein (TAS2R) 7TM_GPCR_Srh PF10318.7 001030606.1_23523001_1 - 1.9 7.3 30.7 17 4.2 30.7 2.0 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srh DUF4407 PF14362.4 001030606.1_23523001_1 - 2.3 7.4 3.8 3.9 6.6 2.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) zf-C2H2_7 PF15269.4 001017786.1_16125001_3 - 8.6e-38 128.1 11.8 2.2e-37 126.8 11.8 1.7 1 0 0 1 1 1 1 Zinc-finger zf-C2H2 PF00096.24 001017786.1_16125001_3 - 1 9.8 5.3 3 8.3 5.3 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type 7tm_4 PF13853.4 001031545.1_23522001_1 - 9.7e-45 153.3 25.8 1.1e-44 153.1 25.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001031545.1_23522001_1 - 2.9e-22 79.1 26.4 6.4e-22 77.9 26.4 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Piwi PF02171.15 183338.1_16127001_1 - 4.1e-103 344.6 0.1 5.6e-103 344.2 0.1 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.20 183338.1_16127001_1 - 8.4e-32 109.7 0.0 1.4e-31 109.0 0.0 1.4 1 0 0 1 1 1 1 PAZ domain GAGE PF05831.9 183338.1_16127001_1 - 3.1e-06 27.5 4.9 5e-06 26.8 4.9 1.3 1 0 0 1 1 1 1 GAGE protein ArgoN PF16486.3 183338.1_16127001_1 - 0.0016 19.0 0.0 0.0035 17.9 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.8 183338.1_16127001_1 - 0.0019 17.7 0.0 0.0046 16.4 0.0 1.7 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.3 183338.1_16127001_1 - 0.0099 16.1 0.2 0.036 14.3 0.1 2.1 2 0 0 2 2 2 1 Argonaute linker 2 domain CDO_I PF05995.10 200741.1_16123001_1 - 3.9e-72 240.9 0.0 7.5e-72 240.0 0.0 1.4 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.10 200741.1_16123001_1 - 2.3e-05 23.8 0.2 0.00013 21.4 0.3 2.0 1 1 0 1 1 1 1 PCO_ADO LMBR1 PF04791.14 001006413.1_23524001_2 - 3.2e-25 88.9 19.1 5.4e-24 84.8 19.1 2.1 1 1 0 1 1 1 1 LMBR1-like membrane protein Pribosyltran PF00156.25 212986.1_16124001_2 - 2.8e-24 85.3 0.0 3.9e-24 84.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.4 212986.1_16124001_2 - 0.076 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase HLH PF00010.24 131231.1_16123001_3 - 6.3e-18 64.4 0.4 1e-17 63.7 0.4 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Dmrt1 PF12374.6 001101831.1_23521001_2 - 4.3e-16 59.0 5.9 8.5e-16 58.0 5.9 1.4 1 0 0 1 1 1 1 Double-sex mab3 related transcription factor 1 DM PF00751.16 001101831.1_23521001_2 - 1.3e-07 31.3 6.7 1.3e-07 31.3 6.7 1.9 2 0 0 2 2 2 1 DM DNA binding domain Ilar_coat PF01787.14 001101831.1_23521001_2 - 0.14 11.8 0.4 0.18 11.5 0.4 1.1 1 0 0 1 1 1 0 Ilarvirus coat protein Ldh_1_N PF00056.21 131246.1_16125001_2 - 2.6e-49 166.8 1.4 3.7e-49 166.3 1.4 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 131246.1_16125001_2 - 4.3e-23 81.9 0.0 7.5e-23 81.1 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.14 131246.1_16125001_2 - 0.083 12.3 1.1 0.16 11.3 0.2 1.8 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase Nipped-B_C PF12830.5 001246284.1_16129001_3 - 3e-65 219.6 13.5 3.8e-65 219.2 3.7 4.1 4 0 0 4 4 4 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.5 001246284.1_16129001_3 - 5e-15 55.2 1.8 6.1e-13 48.5 0.3 3.5 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion HEAT_2 PF13646.4 001246284.1_16129001_3 - 1.2e-05 25.5 0.2 4.4 7.6 0.0 5.3 5 1 1 6 6 6 2 HEAT repeats Cnd1 PF12717.5 001246284.1_16129001_3 - 1.6e-05 24.8 8.0 0.13 12.1 0.0 5.0 3 2 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.20 001246284.1_16129001_3 - 2.3e-05 24.1 6.4 0.16 12.2 0.0 7.5 9 0 0 9 9 8 1 HEAT repeat HEAT_EZ PF13513.4 001246284.1_16129001_3 - 2.5e-05 24.5 0.2 0.96 9.9 0.1 5.6 4 1 1 5 5 5 1 HEAT-like repeat Cnd3 PF12719.5 001246284.1_16129001_3 - 0.029 13.5 9.6 0.068 12.3 1.0 4.2 4 1 0 4 4 4 0 Nuclear condensing complex subunits, C-term domain RIX1 PF08167.10 001246284.1_16129001_3 - 0.05 13.2 0.2 0.76 9.4 0.1 3.1 4 0 0 4 4 4 0 rRNA processing/ribosome biogenesis Nexin_C PF08628.10 001246284.1_16129001_3 - 0.11 13.0 1.3 1.3 9.6 0.1 3.2 3 0 0 3 3 3 0 Sorting nexin C terminal MnmE_helical PF12631.5 001246284.1_16129001_3 - 0.12 12.4 1.5 5.4 7.0 1.5 2.7 1 1 0 1 1 1 0 MnmE helical domain GRP PF07172.9 001246284.1_16129001_3 - 2.8 8.5 5.8 0.61 10.7 1.1 2.4 2 0 0 2 2 1 0 Glycine rich protein family Homeobox PF00046.27 205488.2_23523001_2 - 6.2e-21 73.8 4.6 9.1e-21 73.3 4.6 1.3 1 0 0 1 1 1 1 Homeobox domain HLH PF00010.24 131245.2_16123001_2 - 1.4e-11 44.0 0.1 2.5e-11 43.2 0.1 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Popeye PF04831.11 001001299.2_23524001_3 - 3.4e-47 160.0 1.6 4.3e-47 159.7 1.6 1.1 1 0 0 1 1 1 1 Popeye protein conserved region cNMP_binding PF00027.27 001001299.2_23524001_3 - 0.025 14.5 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain DUF4070 PF13282.4 001001299.2_23524001_3 - 0.074 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4070) Cu2_monoox_C PF03712.13 001109694.2_16124001_1 - 3.6e-64 214.9 0.3 7.2e-64 213.9 0.3 1.5 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Cu2_monooxygen PF01082.18 001109694.2_16124001_1 - 5.4e-46 155.9 0.1 9.8e-46 155.1 0.1 1.5 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain DOMON PF03351.15 001109694.2_16124001_1 - 4.6e-21 75.2 0.0 1.4e-20 73.6 0.0 1.8 2 0 0 2 2 2 1 DOMON domain Peptidase_S41 PF03572.16 131451.2_16125001_2 - 2.5e-43 147.4 0.0 8.8e-24 83.8 0.0 2.2 2 0 0 2 2 2 2 Peptidase family S41 Peptidase_S41_N PF11918.6 131451.2_16125001_2 - 2.3e-41 140.9 0.3 3.3e-34 117.8 0.1 2.6 2 0 0 2 2 2 2 N-terminal domain of Peptidase_S41 in eukaryotic IRBP SDF PF00375.16 001190305.1_16124001_1 - 1.2e-134 449.1 28.6 1.3e-134 448.9 28.6 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family Antimicrobial_6 PF08036.9 001190305.1_16124001_3 - 0.026 14.5 1.1 0.098 12.6 1.1 2.0 1 0 0 1 1 1 0 Diapausin family of antimicrobial peptide Actin PF00022.17 212620.2_16124001_1 - 1.7e-149 497.8 0.0 4.6e-149 496.3 0.0 1.6 1 1 0 1 1 1 1 Actin Homeobox PF00046.27 204911.2_23522001_3 - 1.1e-21 76.3 5.5 1.9e-21 75.5 5.5 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 204911.2_23522001_3 - 0.0049 16.6 0.1 0.013 15.3 0.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain MRP-63 PF14978.4 204911.2_23522001_3 - 0.063 13.8 3.2 0.11 13.0 3.2 1.4 1 0 0 1 1 1 0 Mitochondrial ribosome protein 63 Biopterin_H PF00351.19 214795.2_16125001_3 - 7.2e-174 577.4 0.1 7.2e-174 577.4 0.1 1.4 2 0 0 2 2 2 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.23 214795.2_16125001_3 - 2e-05 24.1 0.0 6e-05 22.6 0.0 1.7 2 0 0 2 2 2 1 ACT domain zf-C2HE PF16278.3 214795.2_16125001_3 - 0.038 14.3 1.1 5 7.5 0.0 2.6 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger DUF4574 PF15141.4 001202436.2_16122001_3 - 4.6e-23 80.8 0.0 7.1e-23 80.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4574) SOXp PF12336.6 205188.2_23523001_2 - 3.4e-38 130.4 5.5 3.4e-38 130.4 5.5 2.3 3 0 0 3 3 3 1 SOX transcription factor HMG_box PF00505.17 205188.2_23523001_2 - 7.3e-28 96.7 3.4 1.2e-27 95.9 3.4 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 205188.2_23523001_2 - 8.5e-12 45.4 1.9 1.5e-11 44.6 1.9 1.4 1 0 0 1 1 1 1 HMG-box domain Tropomyosin PF00261.18 200934.3_16124001_3 - 1.3e-89 299.6 63.4 1.3e-89 299.6 63.4 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.5 200934.3_16124001_3 - 1.7e-33 115.6 71.5 1.6e-29 102.7 37.6 3.0 1 1 1 2 2 2 2 Tropomyosin like Laminin_II PF06009.10 200934.3_16124001_3 - 2.2e-05 24.4 10.4 2.2e-05 24.4 10.4 4.0 1 1 3 4 4 4 2 Laminin Domain II TMF_DNA_bd PF12329.6 200934.3_16124001_3 - 0.0008 19.2 11.2 0.0008 19.2 11.2 5.7 1 1 4 6 6 6 2 TATA element modulatory factor 1 DNA binding CLZ PF16526.3 200934.3_16124001_3 - 0.0026 17.9 47.7 0.041 14.1 8.8 4.7 2 2 2 4 4 4 3 C-terminal leucine zipper domain of cyclic nucleotide-gated channels IncA PF04156.12 200934.3_16124001_3 - 0.082 12.6 60.9 0.11 12.2 22.9 3.1 1 1 2 3 3 3 0 IncA protein Reo_sigmaC PF04582.10 200934.3_16124001_3 - 1.5 8.0 7.5 0.28 10.4 1.8 2.0 2 0 0 2 2 2 0 Reovirus sigma C capsid protein AAA_13 PF13166.4 200934.3_16124001_3 - 4.9 5.6 46.8 0.46 9.0 31.8 2.1 1 1 1 2 2 2 0 AAA domain Alanine_zipper PF11839.6 200934.3_16124001_3 - 6.2 7.0 41.2 1.2 9.3 6.6 4.2 2 1 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein 7tm_1 PF00001.19 001291387.1_02223001_1 - 3.9e-45 154.0 14.8 4.9e-45 153.7 14.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Rhodopsin_N PF10413.7 001291387.1_02223001_1 - 6.5e-25 86.5 3.0 6.5e-25 86.5 3.0 2.1 2 0 0 2 2 2 1 Amino terminal of the G-protein receptor rhodopsin 7TM_GPCR_Srw PF10324.7 001291387.1_02223001_1 - 1.6e-08 34.1 18.5 5.6e-08 32.3 18.5 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.7 001291387.1_02223001_1 - 1.3e-07 31.2 17.7 2.1e-07 30.5 17.7 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 001291387.1_02223001_1 - 5.5e-06 25.8 16.9 8.3e-06 25.2 16.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TAS2R PF05296.11 001291387.1_02223001_1 - 0.0008 18.5 14.3 0.0045 16.0 2.4 2.1 2 0 0 2 2 2 2 Taste receptor protein (TAS2R) 7tm_4 PF13853.4 001291387.1_02223001_1 - 0.14 11.7 18.8 2.9 7.4 18.8 2.1 1 1 0 1 1 1 0 Olfactory receptor TctB PF07331.9 001291387.1_02223001_1 - 6.7 6.8 17.7 7.9 6.6 5.4 2.6 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family NACHT PF05729.10 001328044.1_16129001_2 - 3.6e-35 121.2 0.1 1.5e-34 119.2 0.0 2.1 2 0 0 2 2 2 1 NACHT domain CARD PF00619.19 001328044.1_16129001_2 - 1.6e-20 72.7 0.4 3.7e-09 36.4 0.0 2.7 2 0 0 2 2 2 2 Caspase recruitment domain LRR_6 PF13516.4 001328044.1_16129001_2 - 5.6e-11 41.4 14.9 0.5 10.4 0.1 8.2 8 0 0 8 8 8 3 Leucine Rich repeat LRR_4 PF12799.5 001328044.1_16129001_2 - 7.8e-05 22.8 9.3 1.7 9.0 0.1 5.0 5 0 0 5 5 5 3 Leucine Rich repeats (2 copies) AAA_16 PF13191.4 001328044.1_16129001_2 - 0.00065 20.0 0.0 0.0026 18.0 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.4 001328044.1_16129001_2 - 0.0085 15.7 0.0 0.018 14.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.4 001328044.1_16129001_2 - 0.032 14.4 0.0 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.4 001328044.1_16129001_2 - 0.1 12.2 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.24 001328044.1_16129001_2 - 0.16 11.6 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain zf-B_box PF00643.22 001326489.1_16125001_1 - 1.7e-10 40.7 5.1 1.7e-10 40.7 5.1 4.4 4 1 1 5 5 5 1 B-box zinc finger zf-C3HC4_4 PF15227.4 001326489.1_16125001_1 - 5.5e-10 39.1 9.0 5.5e-10 39.1 9.0 3.3 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 001326489.1_16125001_1 - 1.2e-08 34.7 6.3 4.8e-08 32.7 6.3 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001326489.1_16125001_1 - 1.5e-08 34.2 6.7 1.5e-08 34.2 6.7 3.2 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001326489.1_16125001_1 - 4e-08 32.9 5.0 4e-08 32.9 5.0 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001326489.1_16125001_1 - 7e-07 28.9 8.1 7e-07 28.9 8.1 3.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001326489.1_16125001_1 - 5.3e-05 23.0 6.7 5.3e-05 23.0 6.7 3.1 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 001326489.1_16125001_1 - 5.5e-05 23.2 7.7 5.5e-05 23.2 7.7 3.3 3 0 0 3 3 2 1 Ring finger domain Prok-RING_4 PF14447.4 001326489.1_16125001_1 - 0.00013 21.7 5.7 0.00013 21.7 5.7 3.1 4 0 0 4 4 3 1 Prokaryotic RING finger family 4 IncA PF04156.12 001326489.1_16125001_1 - 0.00079 19.1 9.8 0.00079 19.1 9.8 1.7 2 0 0 2 2 2 1 IncA protein Uteroglobin PF01099.15 001326489.1_16125001_1 - 0.0016 18.4 0.6 0.13 12.3 0.0 2.5 2 0 0 2 2 2 1 Uteroglobin family ALS2CR8 PF15299.4 001326489.1_16125001_1 - 0.0021 17.9 5.4 0.057 13.2 0.9 2.4 2 0 0 2 2 2 2 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 zf-RING_6 PF14835.4 001326489.1_16125001_1 - 0.13 12.0 2.9 0.4 10.5 2.9 1.8 1 0 0 1 1 1 0 zf-RING of BARD1-type protein DUF4407 PF14362.4 001326489.1_16125001_1 - 0.15 11.3 4.7 0.31 10.2 4.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_13 PF13166.4 001326489.1_16125001_1 - 0.15 10.6 9.9 0.067 11.7 7.6 1.4 1 1 0 1 1 1 0 AAA domain zf-UDP PF14569.4 001326489.1_16125001_1 - 2.1 8.4 8.4 0.26 11.3 2.6 2.4 2 0 0 2 2 2 0 Zinc-binding RING-finger Syntaxin-6_N PF09177.9 001326489.1_16125001_1 - 5 7.6 7.2 4.5 7.8 3.4 2.6 2 1 0 2 2 2 0 Syntaxin 6, N-terminal DUF4200 PF13863.4 001326489.1_16125001_1 - 6.1 7.1 24.0 0.051 13.8 14.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) TBCA PF02970.14 001326489.1_16125001_1 - 7 6.9 14.9 0.34 11.1 7.8 2.5 2 0 0 2 2 2 0 Tubulin binding cofactor A PRY PF13765.4 001326489.1_16125001_3 - 3e-15 55.4 1.1 4.9e-15 54.7 0.1 2.0 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.26 001326489.1_16125001_3 - 7.7e-12 45.3 0.2 1.3e-11 44.6 0.2 1.4 1 0 0 1 1 1 1 SPRY domain TLE_N PF03920.13 001313694.1_16126001_2 - 2.5e-70 234.5 6.1 3.6e-70 234.0 6.1 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.30 001313694.1_16126001_2 - 6.6e-16 58.3 19.0 0.02 15.6 1.3 7.8 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001313694.1_16126001_2 - 3.4e-07 30.3 0.0 0.69 10.1 0.0 4.2 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 001313694.1_16126001_2 - 0.0017 17.6 0.0 0.53 9.4 0.0 2.4 2 0 0 2 2 2 2 WD40-like domain HALZ PF02183.16 001313694.1_16126001_2 - 0.014 15.5 0.7 0.034 14.2 0.7 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper Cytochrom_D1 PF02239.14 001313694.1_16126001_2 - 0.065 11.6 0.0 2.1 6.6 0.0 2.3 2 0 0 2 2 2 0 Cytochrome D1 heme domain T-box PF00907.20 153666.2_16127001_2 - 3.1e-74 249.0 0.0 5e-74 248.4 0.0 1.3 1 0 0 1 1 1 1 T-box Trypsin PF00089.24 001089446.1_16124001_2 - 3.7e-70 236.1 2.2 3.7e-70 236.1 2.2 1.4 2 0 0 2 2 2 1 Trypsin DUF1986 PF09342.9 001089446.1_16124001_2 - 2e-08 34.4 0.0 4.6e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Somatomedin_B PF01033.15 001089446.1_16124001_2 - 2.1e-05 24.7 20.2 5.8e-05 23.3 20.2 1.8 1 0 0 1 1 1 1 Somatomedin B domain Trypsin_2 PF13365.4 001089446.1_16124001_2 - 0.0033 18.2 0.4 0.01 16.6 0.4 1.8 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.24 001281994.1_16122001_1 - 1.4e-80 270.1 2.6 1.6e-80 269.9 2.6 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 001281994.1_16122001_1 - 0.00045 20.4 0.0 0.00093 19.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 001281994.1_16122001_1 - 0.0028 18.4 0.0 0.0051 17.6 0.0 1.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain Bmt2 PF11968.6 001030734.1_23528001_1 - 2e-06 27.7 0.4 0.0002 21.2 0.3 2.2 1 1 1 2 2 2 2 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 CAP_N PF01213.17 001030734.1_23528001_1 - 0.24 10.7 7.5 0.38 10.1 7.5 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.9 001030734.1_23528001_1 - 0.43 10.5 1.8 0.78 9.6 1.8 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator PBP_N PF17093.3 001030734.1_23528001_1 - 3.1 7.9 8.0 5.5 7.1 8.0 1.3 1 0 0 1 1 1 0 Penicillin-binding protein N-terminus ATP-gua_Ptrans PF00217.17 205310.1_23523001_1 - 1.1e-97 326.3 0.0 1.5e-97 325.9 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 205310.1_23523001_1 - 1.4e-34 118.2 0.0 2.4e-34 117.4 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain Prothymosin PF03247.12 194376.2_16123001_1 - 1.8e-25 89.4 46.1 1.8e-25 89.4 46.1 2.2 2 0 0 2 2 2 1 Prothymosin/parathymosin family ERCC3_RAD25_C PF16203.3 001006523.2_23527001_2 - 3e-124 413.0 2.2 6.8e-124 411.8 2.2 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.4 001006523.2_23527001_2 - 4.1e-39 133.5 0.0 1e-38 132.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 001006523.2_23527001_2 - 4.5e-16 59.2 0.0 1.2e-15 57.8 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.29 001006523.2_23527001_2 - 2.1e-09 37.6 0.1 5.9e-09 36.1 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.21 001006523.2_23527001_2 - 0.00029 19.5 0.0 0.00047 18.8 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF2605 PF10792.7 001006523.2_23527001_2 - 0.056 13.2 0.3 0.16 11.8 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) Jun PF03957.11 001031289.1_23524001_2 - 2.1e-95 318.9 8.6 3e-95 318.4 8.6 1.2 1 0 0 1 1 1 1 Jun-like transcription factor bZIP_1 PF00170.19 001031289.1_23524001_2 - 1.4e-17 63.4 17.8 3.9e-17 62.0 17.8 1.8 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.15 001031289.1_23524001_2 - 1.4e-08 35.0 9.3 3.5e-08 33.7 9.3 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_2 PF07716.13 001031289.1_23524001_2 - 2.3e-08 33.8 15.1 2.3e-08 33.8 15.1 2.8 3 0 0 3 3 3 1 Basic region leucine zipper ZapB PF06005.10 001031289.1_23524001_2 - 0.0013 19.0 5.7 0.0029 17.9 3.1 2.3 2 0 0 2 2 2 1 Cell division protein ZapB PspA_IM30 PF04012.10 001031289.1_23524001_2 - 0.0035 16.8 4.6 0.0062 16.0 4.6 1.4 1 0 0 1 1 1 1 PspA/IM30 family Jnk-SapK_ap_N PF09744.7 001031289.1_23524001_2 - 0.053 13.6 7.1 0.088 12.9 7.1 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 FlaC_arch PF05377.9 001031289.1_23524001_2 - 0.055 13.7 1.6 0.11 12.7 1.6 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) NBP1 PF08537.8 001031289.1_23524001_2 - 0.058 12.7 2.2 0.087 12.1 2.2 1.2 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 Mnd1 PF03962.13 001031289.1_23524001_2 - 0.072 12.8 2.3 0.11 12.2 2.3 1.2 1 0 0 1 1 1 0 Mnd1 family TSC22 PF01166.16 001031289.1_23524001_2 - 0.13 12.5 0.9 0.35 11.1 0.9 1.7 1 0 0 1 1 1 0 TSC-22/dip/bun family Spc29 PF17082.3 001031289.1_23524001_2 - 0.14 11.8 3.3 0.34 10.6 1.5 2.0 2 0 0 2 2 2 0 Spindle Pole Component 29 DUF3450 PF11932.6 001031289.1_23524001_2 - 0.21 10.7 4.5 0.32 10.1 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF737 PF05300.9 001031289.1_23524001_2 - 2.1 8.5 9.7 3.7 7.7 9.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF737) DUF1664 PF07889.10 001031289.1_23524001_2 - 2.6 7.9 5.0 5.2 7.0 5.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DivIC PF04977.13 001031289.1_23524001_2 - 5.2 6.8 7.4 3.5 7.4 4.7 2.0 1 1 1 2 2 2 0 Septum formation initiator DUF724 PF05266.12 001031289.1_23524001_2 - 9 5.9 8.3 15 5.2 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF3432 PF11914.6 204136.2_23525001_1 - 8.5e-34 115.6 40.6 8.5e-34 115.6 40.6 3.5 3 1 1 4 4 3 1 Domain of unknown function (DUF3432) DUF3446 PF11928.6 204136.2_23525001_1 - 7.1e-25 87.0 15.2 7.1e-25 87.0 15.2 3.9 3 1 1 4 4 2 1 Domain of unknown function (DUF3446) zf-H2C2_2 PF13465.4 204136.2_23525001_1 - 1.5e-15 56.7 18.7 1.6e-07 31.3 0.7 4.4 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.24 204136.2_23525001_1 - 1.9e-13 49.9 20.6 6.9e-05 23.0 0.3 4.5 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 204136.2_23525001_1 - 1.3e-09 37.9 16.6 0.0045 17.6 2.1 4.1 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 204136.2_23525001_1 - 0.0044 17.2 1.8 27 5.1 0.0 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.4 204136.2_23525001_1 - 0.014 15.1 13.5 0.41 10.5 0.4 4.4 4 0 0 4 4 4 0 zinc-finger of a C2HC-type Zf_RING PF16744.3 204136.2_23525001_1 - 0.021 14.8 1.7 0.57 10.2 0.1 2.4 1 1 1 2 2 2 0 KIAA1045 RING finger zf-BED PF02892.13 204136.2_23525001_1 - 0.031 14.2 8.1 0.023 14.6 3.1 2.5 1 1 1 2 2 2 0 BED zinc finger zf-met PF12874.5 204136.2_23525001_1 - 0.052 13.8 8.6 4.8 7.6 1.3 3.8 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 204136.2_23525001_1 - 0.14 12.0 8.3 4.6 7.2 0.3 3.9 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_8 PF15909.3 204136.2_23525001_1 - 0.19 11.9 4.9 0.39 10.9 1.4 2.7 1 1 2 3 3 3 0 C2H2-type zinc ribbon SLC3A2_N PF16028.3 131601.2_16125001_1 - 1.8e-33 113.7 1.7 3.6e-33 112.8 1.7 1.4 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus Alpha-amylase PF00128.22 131601.2_16125001_1 - 1.5e-17 64.0 0.0 9.7e-15 54.8 0.0 2.6 2 1 1 3 3 3 3 Alpha amylase, catalytic domain DUF3487 PF11990.6 131601.2_16125001_1 - 0.28 10.9 1.4 0.33 10.7 0.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) ETAA1 PF15350.4 001111157.1_16125001_3 - 7.4e-49 166.7 38.7 1.2e-30 106.5 1.8 5.1 2 1 3 5 5 5 5 Ewing's tumour-associated antigen 1 homologue PH PF00169.27 200841.1_16124001_1 - 4.7e-36 123.3 0.2 4.9e-19 68.6 0.2 2.7 3 0 0 3 3 3 2 PH domain DEP PF00610.19 200841.1_16124001_1 - 2.1e-15 56.4 0.0 4.6e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_9 PF15410.4 200841.1_16124001_1 - 1.2e-12 48.1 0.6 2.4e-07 31.0 0.6 3.0 2 1 0 2 2 2 2 Pleckstrin homology domain PH_6 PF15406.4 200841.1_16124001_1 - 9.9e-08 32.1 0.3 9.7e-05 22.5 0.1 2.4 2 0 0 2 2 2 2 Pleckstrin homology domain zf-C2H2 PF00096.24 001080003.1_16124001_3 - 1.2e-14 53.7 22.5 7.6e-06 26.0 4.0 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001080003.1_16124001_3 - 1.8e-10 40.7 7.7 3.7e-07 30.2 1.5 3.6 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001080003.1_16124001_3 - 6.7e-07 29.5 18.8 0.028 15.1 2.1 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.5 001080003.1_16124001_3 - 0.0025 18.0 5.2 0.25 11.7 0.5 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type DUF3850 PF12961.5 001080003.1_16124001_3 - 0.095 12.8 0.1 1.1 9.4 0.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3850) zf-C2H2_jaz PF12171.6 001080003.1_16124001_3 - 0.12 12.6 1.3 5.7 7.2 0.0 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding P3A PF08727.9 001080003.1_16124001_3 - 0.14 11.4 0.4 0.39 10.0 0.4 1.7 1 0 0 1 1 1 0 Poliovirus 3A protein like FOXP-CC PF16159.3 001080003.1_16124001_3 - 0.59 10.7 3.6 8.3 7.0 0.9 2.7 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.4 001080003.1_16124001_3 - 3.6 7.5 9.1 0.14 12.0 0.5 2.8 2 1 0 2 2 2 0 C2H2-type zinc finger PTR2 PF00854.19 001320529.1_16126001_3 - 8.3e-102 340.8 2.1 8.3e-102 340.8 2.1 1.7 2 0 0 2 2 2 1 POT family MFS_1 PF07690.14 001320529.1_16126001_3 - 0.00022 20.2 35.3 0.0016 17.3 34.1 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Actin PF00022.17 200170.1_16125001_3 - 1e-48 165.9 0.0 8.7e-47 159.5 0.0 2.3 1 1 0 1 1 1 1 Actin Prenyltrans PF00432.19 001030255.2_16124001_2 - 4.2e-34 115.8 9.5 5.1e-10 38.8 0.0 6.3 6 0 0 6 6 6 4 Prenyltransferase and squalene oxidase repeat MFS_1 PF07690.14 001037385.1_16124001_1 - 5.9e-31 107.5 55.3 1.3e-24 86.7 29.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.11 001037385.1_16124001_1 - 0.0001 20.7 12.4 0.00074 17.9 4.3 3.0 1 1 1 3 3 3 2 Transmembrane secretion effector Thyroglobulin_1 PF00086.16 173283.3_16124001_3 - 4e-18 64.7 2.6 4e-18 64.7 2.6 1.7 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 173283.3_16124001_3 - 1.5e-08 35.0 20.5 1.5e-08 35.0 20.5 2.0 2 0 0 2 2 2 1 Insulin-like growth factor binding protein CRF PF00473.15 001123031.1_23522001_3 - 5.5e-16 58.3 1.1 5.5e-16 58.3 1.1 2.0 2 0 0 2 2 2 1 Corticotropin-releasing factor family SNF PF00209.16 001126386.1_16126001_2 - 5.8e-241 800.6 35.7 6.9e-241 800.3 35.7 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Ras PF00071.20 001002061.1_16123001_1 - 1.1e-53 181.0 0.0 1.5e-53 180.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001002061.1_16123001_1 - 4.1e-22 78.5 0.0 6.7e-22 77.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001002061.1_16123001_1 - 2.2e-07 30.4 0.0 3.2e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Leo1 PF04004.11 207067.1_16125001_3 - 2.8e-55 186.6 0.0 2.8e-55 186.6 0.0 2.5 3 0 0 3 3 3 1 Leo1-like protein Peptidase_C13 PF01650.16 214759.1_16125001_1 - 1.5e-116 388.3 1.8 1.5e-116 388.3 1.8 1.9 2 0 0 2 2 2 1 Peptidase C13 family Peptidase_C14 PF00656.20 214759.1_16125001_1 - 0.00014 21.8 0.0 0.00029 20.7 0.0 1.4 1 1 0 1 1 1 1 Caspase domain Aa_trans PF01490.16 001045104.1_16129001_1 - 1.5e-82 277.4 35.1 2e-82 276.9 35.1 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AAA_18 PF13238.4 001327784.1_16123001_1 - 3.9e-17 62.9 0.0 5.9e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 001327784.1_16123001_1 - 0.011 15.7 0.0 0.19 11.8 0.0 2.2 1 1 0 1 1 1 0 AAA domain EMP24_GP25L PF01105.22 212912.2_16123001_2 - 5.9e-48 163.1 0.2 5.9e-48 163.1 0.2 1.9 2 0 0 2 2 2 1 emp24/gp25L/p24 family/GOLD Cadherin PF00028.15 001024097.1_16129001_1 - 3.2e-83 274.2 6.4 2.7e-20 72.5 0.2 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001024097.1_16129001_1 - 1.8e-54 183.5 3.3 3.6e-54 182.6 3.3 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001024097.1_16129001_1 - 1.2e-33 114.6 0.5 7e-29 99.3 0.1 4.4 4 0 0 4 4 4 2 Cadherin-like Cadherin_C_2 PF16492.3 001024097.1_16129001_1 - 4.1e-11 43.4 0.7 1.1e-10 42.0 0.7 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal TGFb_propeptide PF00688.16 130960.1_16123001_2 - 4e-20 72.5 1.3 3.6e-19 69.3 1.3 1.9 1 1 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 130960.1_16123001_2 - 4.2e-13 49.9 3.8 1.9e-11 44.7 3.8 2.5 1 1 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 182873.1_16124001_1 - 3.2e-33 115.4 0.3 4.2e-33 115.0 0.3 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 182873.1_16124001_1 - 5.6e-23 81.7 2.9 1.2e-22 80.7 2.9 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain Sema PF01403.17 212999.3_16127001_2 - 3.4e-125 418.0 0.4 3.4e-125 418.0 0.4 1.5 2 0 0 2 2 2 1 Sema domain PSI PF01437.23 212999.3_16127001_2 - 0.00019 21.8 3.1 0.00071 19.9 3.1 2.1 1 0 0 1 1 1 1 Plexin repeat Presenilin PF01080.15 131514.2_16124001_1 - 5.3e-158 525.8 13.4 8.2e-111 370.4 13.1 2.3 1 1 1 2 2 2 2 Presenilin ABC2_membrane_2 PF12679.5 131514.2_16124001_1 - 0.099 11.8 0.1 0.099 11.8 0.1 2.6 2 1 0 2 2 2 0 ABC-2 family transporter protein DUF3377 PF11857.6 131514.2_16124001_1 - 0.96 9.3 0.0 0.96 9.3 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3377) RNA_GG_bind PF10258.7 001003995.1_16124001_2 - 3.3e-33 113.4 0.1 7.8e-33 112.2 0.1 1.6 1 0 0 1 1 1 1 PHAX RNA-binding domain Ctr PF04145.13 001320405.1_16129001_3 - 9.5e-32 110.5 3.7 1.5e-31 109.9 3.7 1.3 1 0 0 1 1 1 1 Ctr copper transporter family Nuc_sug_transp PF04142.13 001130073.1_16123001_2 - 2.4e-130 434.2 24.3 2.8e-130 434.0 24.3 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.18 001130073.1_16123001_2 - 1.4e-07 31.6 34.6 2.3e-05 24.5 10.3 2.5 2 1 0 2 2 2 2 EamA-like transporter family EmrE PF13536.4 001130073.1_16123001_2 - 9.5e-05 22.0 5.7 9.5e-05 22.0 5.7 1.9 1 1 0 2 2 2 1 Putative multidrug resistance efflux transporter PUNUT PF16913.3 001130073.1_16123001_2 - 0.00019 20.7 23.6 0.00035 19.8 23.6 1.5 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport UAA PF08449.9 001130073.1_16123001_2 - 0.0082 15.2 18.9 0.035 13.2 16.3 2.7 1 1 1 2 2 2 1 UAA transporter family TPT PF03151.14 001130073.1_16123001_2 - 0.24 10.6 17.6 18 4.4 17.7 2.8 1 1 0 1 1 1 0 Triose-phosphate Transporter family Mito_carr PF00153.25 131382.1_16124001_2 - 7.5e-19 67.3 0.0 3.9e-11 42.6 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein MIP PF00230.18 001033096.1_16124001_3 - 3.6e-48 164.1 11.5 5e-48 163.6 11.5 1.1 1 0 0 1 1 1 1 Major intrinsic protein Phage_holin_5_2 PF16079.3 001033096.1_16124001_3 - 1.2 9.3 0.0 1.2 9.3 0.0 3.2 3 1 0 3 3 3 0 Phage holin family Hol44, in holin superfamily V Pkinase PF00069.23 001045552.1_16125001_1 - 3e-70 236.4 0.0 4.4e-70 235.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001045552.1_16125001_1 - 3.4e-25 88.7 0.0 6.9e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001045552.1_16125001_1 - 0.0038 17.0 0.0 0.01 15.7 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family LELP1 PF15042.4 001045552.1_16125001_1 - 0.29 11.5 4.7 0.87 9.9 0.1 3.2 3 0 0 3 3 3 0 Late cornified envelope-like proline-rich protein 1 Ion_trans PF00520.29 200132.2_16129001_1 - 2.2e-247 816.2 108.5 8.2e-80 267.4 13.1 4.2 4 0 0 4 4 4 4 Ion transport protein Na_trans_assoc PF06512.11 200132.2_16129001_1 - 1.1e-47 162.7 3.4 1.1e-47 162.7 3.4 3.4 4 0 0 4 4 4 1 Sodium ion transport-associated Na_trans_cytopl PF11933.6 200132.2_16129001_1 - 3.2e-28 98.9 12.7 9.1e-28 97.5 12.7 1.8 1 0 0 1 1 1 1 Cytoplasmic domain of voltage-gated Na+ ion channel GPHH PF16905.3 200132.2_16129001_1 - 9.6e-08 31.6 0.0 2.2e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.10 200132.2_16129001_1 - 2.6e-06 26.3 92.6 6.8e-05 21.6 2.8 9.5 6 4 4 10 10 10 6 Polycystin cation channel Zip PF02535.20 200132.2_16129001_1 - 0.0054 15.9 0.0 0.0054 15.9 0.0 2.9 3 0 0 3 3 3 1 ZIP Zinc transporter ATP-synt_B PF00430.16 200132.2_16129001_1 - 0.0096 15.9 4.6 0.039 13.9 4.6 2.2 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) IQ PF00612.25 200132.2_16129001_1 - 0.034 13.8 0.2 0.21 11.4 0.0 2.3 2 0 0 2 2 2 0 IQ calmodulin-binding motif Lustrin_cystein PF14625.4 200132.2_16129001_1 - 0.18 12.1 3.3 0.12 12.6 0.4 2.3 2 0 0 2 2 2 0 Lustrin, cysteine-rich repeated domain ATP-synt_F6 PF05511.9 200132.2_16129001_1 - 4.7 7.5 5.6 1.1 9.6 0.4 2.6 3 0 0 3 3 3 0 Mitochondrial ATP synthase coupling factor 6 LRR_8 PF13855.4 001013570.2_16124001_3 - 3.1e-16 58.8 2.2 9.3e-07 28.4 0.0 3.8 3 0 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 001013570.2_16124001_3 - 1.7e-07 31.3 6.8 0.21 11.9 0.0 4.6 1 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 001013570.2_16124001_3 - 0.0031 17.3 2.8 11 6.3 0.1 4.8 5 0 0 5 5 5 1 Leucine Rich repeat LRR_5 PF13306.4 001013570.2_16124001_3 - 0.0075 16.1 5.4 0.017 15.0 0.1 3.1 3 1 0 3 3 3 1 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001013570.2_16124001_3 - 0.017 14.5 0.3 0.37 10.1 0.1 2.4 1 1 0 2 2 2 0 Leucine-rich repeat LRR_1 PF00560.31 001013570.2_16124001_3 - 0.051 13.9 3.5 64 4.5 0.9 5.3 4 2 0 4 4 4 0 Leucine Rich Repeat AAA_18 PF13238.4 102288.1_16124120_1 - 7.9e-06 26.3 0.0 1.1e-05 25.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 102288.1_16124120_2 - 0.0069 16.8 0.1 0.0097 16.3 0.1 1.2 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.21 102288.1_16124120_2 - 0.1 12.6 0.7 0.16 12.0 0.1 1.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_33 PF13671.4 102288.1_16124120_2 - 0.13 12.3 0.0 0.2 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain RRM_1 PF00076.20 132430.1_16123120_2 - 6.1e-22 77.1 0.0 9e-22 76.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 132430.1_16123120_2 - 0.0041 16.9 0.0 0.0067 16.3 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Presenilin PF01080.15 132430.1_16123120_2 - 2.7 6.5 10.0 3.9 6.0 10.0 1.2 1 0 0 1 1 1 0 Presenilin 7tm_1 PF00001.19 001113290.1_23523001_2 - 1.3e-85 286.8 12.5 1.8e-85 286.3 12.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001113290.1_23523001_2 - 1.8e-18 66.7 21.3 7.4e-14 51.6 13.6 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001113290.1_23523001_2 - 4.8e-05 22.7 25.7 0.0089 15.3 18.3 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001113290.1_23523001_2 - 0.00037 20.2 12.2 0.00037 20.2 12.2 2.4 2 1 0 2 2 2 1 Olfactory receptor RAMP4 PF06624.10 001113290.1_23523001_2 - 0.014 15.3 0.1 0.59 10.1 0.0 2.7 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 Rifin_STEVOR PF02009.14 001113290.1_23523001_2 - 0.024 14.4 0.6 0.065 13.0 0.6 1.7 1 0 0 1 1 1 0 Rifin/stevor family CcmH PF03918.12 001113290.1_23523001_2 - 0.042 13.0 0.1 0.56 9.4 0.0 2.3 2 0 0 2 2 2 0 Cytochrome C biogenesis protein DUF3806 PF12713.5 001113290.1_23523001_2 - 0.071 12.8 1.3 2.5 7.8 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3806) DUF912 PF06024.10 001113290.1_23523001_2 - 0.33 11.2 8.7 3.2 8.0 0.7 3.7 3 1 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) TMEM154 PF15102.4 001113290.1_23523001_2 - 0.83 9.4 3.6 1.5 8.6 0.7 2.7 3 1 0 3 3 3 0 TMEM154 protein family DUF1230 PF06799.9 001113290.1_23523001_2 - 0.87 9.6 8.3 1.4 8.9 1.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1230) Virul_fac_BrkB PF03631.13 001113290.1_23523001_2 - 2.9 7.3 16.3 0.033 13.7 2.2 2.9 3 0 0 3 3 3 0 Virulence factor BrkB GWT1 PF06423.10 001113290.1_23523001_2 - 5.7 6.9 16.5 30 4.6 0.0 3.7 2 1 0 2 2 2 0 GWT1 Tissue_fac PF01108.15 001360849.1_37527001_2 - 1.4e-10 40.8 0.1 3.7e-10 39.5 0.1 1.7 1 0 0 1 1 1 1 Tissue factor Tissue_fac PF01108.15 001360850.1_37527001_2 - 0.011 15.5 4.6 0.011 15.4 0.4 2.8 2 1 0 2 2 2 0 Tissue factor 7tm_1 PF00001.19 001142849.2_23523001_3 - 6e-72 242.0 4.2 7.1e-72 241.7 4.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001142849.2_23523001_3 - 6.8e-12 45.2 11.4 2.1e-06 27.2 7.0 2.0 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001142849.2_23523001_3 - 2.7e-06 27.2 9.9 8.3e-06 25.6 3.2 2.1 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001142849.2_23523001_3 - 0.0029 16.8 8.1 0.0029 16.8 8.1 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx LRR_8 PF13855.4 001082800.1_16123001_3 - 5.1e-22 77.3 18.0 3.8e-10 39.3 5.1 4.1 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.5 001082800.1_16123001_3 - 4.9e-15 55.2 27.1 1.8e-07 31.2 1.7 5.6 3 2 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001082800.1_16123001_3 - 0.00073 18.9 9.2 0.0093 15.4 3.1 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.31 001082800.1_16123001_3 - 0.0013 18.8 20.0 2.3 8.9 0.0 6.6 7 0 0 7 7 7 3 Leucine Rich Repeat LRR_6 PF13516.4 001082800.1_16123001_3 - 1.7 8.8 25.7 0.74 9.9 0.5 6.4 6 0 0 6 6 6 0 Leucine Rich repeat LRR_3 PF07725.10 001082800.1_16123001_3 - 8.4 6.3 14.8 12 5.8 0.1 5.5 6 0 0 6 6 6 0 Leucine Rich Repeat Na_H_Exchanger PF00999.19 001285935.1_23529001_1 - 5.9e-90 301.7 45.6 9.1e-90 301.1 45.6 1.3 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.3 001285935.1_23529001_1 - 4.2e-40 136.4 8.6 8.2e-40 135.5 8.6 1.5 1 0 0 1 1 1 1 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin DUF3446 PF11928.6 036628.1_16127120_1 - 0.13 12.4 8.6 0.31 11.2 8.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) DUF755 PF05501.9 036628.1_16127120_1 - 0.73 10.0 11.9 1.4 9.1 11.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) SR-25 PF10500.7 036628.1_16127120_1 - 1.3 8.4 10.3 2.2 7.7 10.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein LRR_8 PF13855.4 001276357.1_23525001_3 - 6.6e-35 118.5 33.2 1.1e-12 47.3 6.4 6.6 3 1 4 7 7 7 6 Leucine rich repeat LRR_4 PF12799.5 001276357.1_23525001_3 - 6.8e-22 77.0 39.4 1.5e-05 25.0 4.2 7.4 2 1 5 8 8 8 8 Leucine Rich repeats (2 copies) LRRNT PF01462.16 001276357.1_23525001_3 - 1e-07 31.3 2.5 1e-07 31.3 2.5 2.8 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.4 001276357.1_23525001_3 - 2.6e-07 30.0 25.8 0.04 13.9 0.0 7.9 7 0 0 7 7 7 3 Leucine Rich repeat LRR_9 PF14580.4 001276357.1_23525001_3 - 8.9e-07 28.4 10.7 0.013 14.9 0.7 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.31 001276357.1_23525001_3 - 0.00032 20.6 27.3 28 5.6 0.2 10.2 8 3 1 9 9 9 0 Leucine Rich Repeat Glycolytic PF00274.17 001007977.2_23524001_2 - 2.3e-177 588.9 0.1 2.7e-177 588.6 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Jun PF03957.11 199987.1_16124001_3 - 4.1e-91 304.8 9.0 5.6e-91 304.4 9.0 1.2 1 0 0 1 1 1 1 Jun-like transcription factor bZIP_1 PF00170.19 199987.1_16124001_3 - 2.8e-17 62.4 16.7 2.8e-17 62.4 16.7 3.1 3 0 0 3 3 3 1 bZIP transcription factor bZIP_Maf PF03131.15 199987.1_16124001_3 - 2.1e-08 34.4 8.8 2.1e-08 34.4 8.8 3.2 3 0 0 3 3 3 1 bZIP Maf transcription factor bZIP_2 PF07716.13 199987.1_16124001_3 - 6.4e-08 32.4 13.2 6.4e-08 32.4 13.2 4.1 4 1 0 4 4 4 1 Basic region leucine zipper ZapB PF06005.10 199987.1_16124001_3 - 0.0088 16.3 2.2 0.0088 16.3 2.2 3.0 3 0 0 3 3 3 1 Cell division protein ZapB FlaC_arch PF05377.9 199987.1_16124001_3 - 0.27 11.5 5.0 0.089 13.1 1.9 1.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) HLH PF00010.24 205619.1_16123001_2 - 6e-15 54.8 0.4 1.1e-14 53.9 0.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Sox_N PF12444.6 131643.1_16124001_2 - 3.6e-25 88.7 0.3 3.6e-25 88.7 0.3 3.0 2 1 0 2 2 2 1 Sox developmental protein N terminal HMG_box PF00505.17 131643.1_16124001_2 - 5.1e-25 87.6 1.0 1.1e-24 86.5 1.0 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 131643.1_16124001_2 - 3.1e-10 40.4 0.8 7.7e-10 39.1 0.8 1.7 1 0 0 1 1 1 1 HMG-box domain TNF PF00229.16 212859.2_16123001_2 - 8.3e-33 112.9 0.0 1.5e-32 112.1 0.0 1.4 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Connexin PF00029.17 212859.2_16123001_2 - 0.0031 17.2 3.5 0.0055 16.4 3.5 1.5 1 0 0 1 1 1 1 Connexin GWT1 PF06423.10 212859.2_16123001_2 - 0.0043 17.1 0.1 0.013 15.5 0.2 1.8 2 0 0 2 2 2 1 GWT1 DUF788 PF05620.9 212859.2_16123001_2 - 0.0092 15.8 5.7 0.02 14.7 5.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF788) 7tm_1 PF00001.19 212859.2_16123001_2 - 0.044 12.9 4.8 0.075 12.1 4.8 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) FAM176 PF14851.4 212859.2_16123001_2 - 0.058 12.9 0.2 0.23 11.0 0.1 2.1 2 0 0 2 2 2 0 FAM176 family Zip PF02535.20 212859.2_16123001_2 - 0.1 11.6 0.9 0.13 11.3 0.2 1.5 2 0 0 2 2 2 0 ZIP Zinc transporter Sm_multidrug_ex PF06695.9 212859.2_16123001_2 - 1.8 9.1 4.6 4.5 7.8 4.6 1.6 1 0 0 1 1 1 0 Putative small multi-drug export protein HLH PF00010.24 131041.1_16123001_3 - 6.6e-16 57.9 0.1 1.6e-15 56.7 0.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Ephrin PF00812.15 131023.1_16122001_1 - 5.4e-48 162.4 0.1 4.8e-47 159.3 0.0 2.0 2 0 0 2 2 2 1 Ephrin Rifin_STEVOR PF02009.14 131023.1_16122001_1 - 5.9e-05 23.0 0.0 7.1e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Rifin/stevor family TMEM132D_C PF15706.3 131023.1_16122001_1 - 0.0046 16.6 0.0 0.0084 15.7 0.0 1.4 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Herpes_LMP2 PF07415.9 131023.1_16122001_1 - 0.02 13.5 0.2 0.032 12.9 0.2 1.2 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein EphA2_TM PF14575.4 131023.1_16122001_1 - 0.039 14.6 0.0 0.074 13.7 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ECSCR PF15820.3 131023.1_16122001_1 - 0.061 13.0 0.1 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator TMEM154 PF15102.4 131023.1_16122001_1 - 0.061 13.1 0.0 0.093 12.5 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family SKG6 PF08693.8 131023.1_16122001_1 - 4 6.8 6.6 8.4 5.8 6.6 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Pou PF00157.15 131112.1_16125001_3 - 2.3e-37 126.7 0.8 4e-37 125.9 0.8 1.4 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 131112.1_16125001_3 - 2.3e-16 59.2 0.1 1e-15 57.1 0.0 2.1 2 0 0 2 2 2 1 Homeobox domain CH PF00307.29 199881.1_16127001_1 - 3.4e-85 281.3 0.3 9.4e-25 86.8 0.1 4.3 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.4 199881.1_16127001_1 - 3.9e-10 39.9 0.6 1.1e-09 38.5 0.6 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 199881.1_16127001_1 - 2.2e-09 36.1 2.8 0.00012 21.2 0.3 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 199881.1_16127001_1 - 2.9e-07 29.8 2.0 0.00086 18.9 0.3 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.4 199881.1_16127001_1 - 8.3e-07 28.6 1.1 0.049 13.3 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair CAMSAP_CH PF11971.6 199881.1_16127001_1 - 1.5e-06 27.8 0.1 0.0035 17.0 0.1 3.7 3 0 0 3 3 3 1 CAMSAP CH domain EF-hand_5 PF13202.4 199881.1_16127001_1 - 5.9e-06 25.4 3.3 0.0049 16.2 0.3 2.9 2 0 0 2 2 2 2 EF hand Insulin PF00049.16 001004384.2_23522001_1 - 3.9e-14 53.3 6.0 1.5e-11 45.0 6.0 2.6 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family ABC_tran PF00005.25 213051.2_16126001_3 - 7.3e-34 117.1 0.0 1.8e-15 57.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter RLI PF04068.13 213051.2_16126001_3 - 1.9e-14 53.0 7.2 6.1e-14 51.4 7.2 2.0 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.17 213051.2_16126001_3 - 3.4e-10 39.6 2.6 0.0025 17.1 0.0 4.0 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 213051.2_16126001_3 - 2.1e-09 37.5 4.5 0.074 12.7 0.1 4.2 2 2 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system Fer4 PF00037.25 213051.2_16126001_3 - 5e-08 32.3 1.5 5e-08 32.3 1.5 3.1 4 0 0 4 4 3 1 4Fe-4S binding domain Fer4_6 PF12837.5 213051.2_16126001_3 - 1e-05 25.2 0.8 1e-05 25.2 0.8 3.0 3 0 0 3 3 2 1 4Fe-4S binding domain AAA_15 PF13175.4 213051.2_16126001_3 - 0.0001 21.9 0.0 0.52 9.7 0.0 2.6 3 0 0 3 3 2 2 AAA ATPase domain AAA PF00004.27 213051.2_16126001_3 - 0.00012 22.4 0.0 0.2 12.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.4 213051.2_16126001_3 - 0.00014 21.4 1.0 0.26 10.9 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.14 213051.2_16126001_3 - 0.0002 21.2 0.1 0.25 11.1 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.4 213051.2_16126001_3 - 0.00033 21.0 0.0 0.55 10.4 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.4 213051.2_16126001_3 - 0.0011 19.4 0.2 0.13 12.6 0.2 2.4 2 0 0 2 2 2 1 AAA domain Fer4_2 PF12797.5 213051.2_16126001_3 - 0.0012 18.7 0.6 0.0012 18.7 0.6 3.0 2 0 0 2 2 2 1 4Fe-4S binding domain NACHT PF05729.10 213051.2_16126001_3 - 0.002 18.0 0.7 0.17 11.6 0.0 2.5 2 0 0 2 2 2 1 NACHT domain Fer4_7 PF12838.5 213051.2_16126001_3 - 0.0053 17.2 0.5 0.0053 17.2 0.5 3.0 3 0 0 3 3 3 1 4Fe-4S dicluster domain AAA_22 PF13401.4 213051.2_16126001_3 - 0.0059 16.8 0.0 0.73 10.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain Fer4_10 PF13237.4 213051.2_16126001_3 - 0.0065 16.4 1.4 0.0065 16.4 1.4 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.4 213051.2_16126001_3 - 0.0077 16.2 13.0 0.027 14.5 12.6 2.1 1 1 1 2 2 2 1 4Fe-4S dicluster domain AAA_24 PF13479.4 213051.2_16126001_3 - 0.0087 15.7 0.8 0.85 9.2 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 213051.2_16126001_3 - 0.013 15.1 0.1 0.45 10.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain Fer4_9 PF13187.4 213051.2_16126001_3 - 0.021 14.9 11.7 0.063 13.3 11.4 2.0 1 1 1 2 2 2 0 4Fe-4S dicluster domain AAA_33 PF13671.4 213051.2_16126001_3 - 0.024 14.7 0.1 3.1 7.8 0.1 2.4 2 0 0 2 2 2 0 AAA domain TsaE PF02367.15 213051.2_16126001_3 - 0.024 14.5 0.2 0.21 11.4 0.1 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.20 213051.2_16126001_3 - 0.03 14.6 0.7 11 6.3 0.1 3.3 4 0 0 4 4 3 0 RNA helicase SRP54 PF00448.20 213051.2_16126001_3 - 0.031 13.8 3.1 0.7 9.3 0.1 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Fer4_16 PF13484.4 213051.2_16126001_3 - 0.038 14.8 0.8 0.038 14.8 0.8 2.7 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain NB-ARC PF00931.20 213051.2_16126001_3 - 0.16 10.8 0.3 16 4.3 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_28 PF13521.4 213051.2_16126001_3 - 0.26 11.4 1.7 21 5.2 0.1 2.4 2 0 0 2 2 2 0 AAA domain Fer4_8 PF13183.4 213051.2_16126001_3 - 4.2 7.8 10.0 0.49 10.7 1.0 2.6 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_4 PF12800.5 213051.2_16126001_3 - 4.2 8.0 13.9 0.73 10.4 2.6 2.8 2 0 0 2 2 2 0 4Fe-4S binding domain RFX_DNA_binding PF02257.13 205712.1_16127001_2 - 2.4e-33 114.4 0.0 7.8e-33 112.8 0.0 1.9 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.14 205712.1_16127001_2 - 0.0014 18.9 0.1 0.0078 16.6 0.0 2.1 2 0 0 2 2 2 1 Poxvirus D5 protein-like C1-set PF07654.13 131163.2_16123001_2 - 9.8e-21 73.9 0.1 1.4e-20 73.4 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_2 PF13895.4 131163.2_16123001_2 - 0.00052 20.2 0.0 0.0009 19.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 131163.2_16123001_2 - 0.06 13.8 0.0 0.094 13.2 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin domain Cna_B PF05738.11 131163.2_16123001_2 - 0.12 12.9 0.0 0.19 12.2 0.0 1.2 1 0 0 1 1 1 0 Cna protein B-type domain DNA_methylase PF00145.15 001018134.1_16126001_2 - 4.5e-17 62.3 0.0 3.8e-12 46.1 0.0 2.2 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase PWWP PF00855.15 001018134.1_16126001_2 - 3.2e-10 40.2 0.8 1.1e-09 38.5 0.2 2.3 3 0 0 3 3 3 1 PWWP domain GCR PF02155.13 001020711.3_16128001_1 - 2.2e-131 438.2 8.2 2.9e-131 437.8 8.2 1.1 1 0 0 1 1 1 1 Glucocorticoid receptor Hormone_recep PF00104.28 001020711.3_16128001_1 - 6.1e-33 114.0 1.9 9.9e-33 113.3 1.9 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001020711.3_16128001_1 - 1.4e-27 95.8 13.2 2.7e-27 94.9 13.2 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) ABC_tran PF00005.25 001128690.1_16125001_1 - 4.5e-27 95.1 0.1 9.4e-27 94.1 0.1 1.6 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.22 001128690.1_16125001_1 - 4.6e-23 81.6 12.7 6.5e-23 81.1 12.7 1.2 1 0 0 1 1 1 1 ABC-2 type transporter AAA_21 PF13304.4 001128690.1_16125001_1 - 7.8e-07 29.0 2.1 0.0067 16.1 0.7 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001128690.1_16125001_1 - 1.5e-05 24.5 0.2 2.9e-05 23.5 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.17 001128690.1_16125001_1 - 9.9e-05 21.7 0.2 0.0025 17.1 0.2 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.4 001128690.1_16125001_1 - 0.00015 22.2 0.0 0.00029 21.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 001128690.1_16125001_1 - 0.00051 20.3 0.1 0.00095 19.5 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.14 001128690.1_16125001_1 - 0.0074 16.1 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 NACHT PF05729.10 001128690.1_16125001_1 - 0.01 15.6 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.20 001128690.1_16125001_1 - 0.039 12.8 0.0 0.06 12.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain NTPase_1 PF03266.13 001128690.1_16125001_1 - 0.048 13.4 0.2 2.1 8.1 0.0 2.3 2 0 0 2 2 2 0 NTPase AAA_5 PF07728.12 001128690.1_16125001_1 - 0.065 13.1 0.1 1.6 8.6 0.0 2.6 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.4 001128690.1_16125001_1 - 0.092 13.1 0.0 0.21 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain ArgK PF03308.14 001128690.1_16125001_1 - 0.11 11.3 0.0 0.24 10.2 0.0 1.4 1 0 0 1 1 1 0 ArgK protein MobB PF03205.12 001128690.1_16125001_1 - 0.15 11.8 0.1 0.26 11.0 0.1 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF3810 PF12725.5 001128690.1_16125001_1 - 0.17 11.0 0.4 0.37 9.9 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) AAA_30 PF13604.4 001128690.1_16125001_1 - 0.18 11.4 0.0 0.39 10.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Yip1 PF04893.15 001128690.1_16125001_1 - 3.2 7.3 18.2 0.017 14.7 9.4 1.7 2 1 0 2 2 1 0 Yip1 domain PAS_11 PF14598.4 130957.2_16127001_2 - 9e-21 74.0 0.0 9e-21 74.0 0.0 4.4 4 0 0 4 4 4 1 PAS domain PAS_3 PF08447.10 130957.2_16127001_2 - 5.1e-18 65.0 0.4 2.4e-15 56.4 0.1 2.9 3 0 0 3 3 3 2 PAS fold HLH PF00010.24 130957.2_16127001_2 - 1.5e-09 37.5 1.1 3.7e-09 36.3 1.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS PF00989.23 130957.2_16127001_2 - 3.3e-07 30.2 13.7 5.6e-07 29.4 0.0 4.4 4 0 0 4 4 4 1 PAS fold PAS_9 PF13426.5 130957.2_16127001_2 - 0.0022 18.1 1.6 0.005 17.0 0.0 2.5 2 0 0 2 2 2 1 PAS domain AAA_23 PF13476.4 130957.2_16127001_2 - 4.1 7.7 37.2 0.45 10.9 2.4 3.0 3 0 0 3 3 3 0 AAA domain AhpC-TSA PF00578.19 001013471.2_16123001_2 - 7.1e-40 135.7 0.0 1e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.8 001013471.2_16123001_2 - 3e-15 56.0 0.0 8e-15 54.7 0.0 1.6 2 0 0 2 2 2 1 Redoxin 1-cysPrx_C PF10417.7 001013471.2_16123001_2 - 4.5e-14 51.9 0.1 7.4e-14 51.2 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin TORC_M PF12885.5 001013471.2_16123001_3 - 0.06 13.2 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Transducer of regulated CREB activity middle domain Histone_H2A_C PF16211.3 001013471.2_16123001_3 - 6.3 6.5 6.2 9.3 6.0 5.1 1.9 2 0 0 2 2 2 0 C-terminus of histone H2A DNA_methylase PF00145.15 001328167.1_16128001_3 - 1.2e-16 60.9 0.0 1e-12 47.9 0.0 2.3 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase PWWP PF00855.15 001328167.1_16128001_3 - 1.2e-11 44.8 1.0 2.8e-11 43.6 0.4 2.0 2 0 0 2 2 2 1 PWWP domain Spt20 PF12090.6 001328167.1_16128001_3 - 2.3 7.6 11.2 7.4 6.0 10.7 1.9 2 0 0 2 2 2 0 Spt20 family EF-hand_6 PF13405.4 200672.1_16125001_1 - 0.0065 16.2 0.0 0.023 14.5 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.30 200672.1_16125001_1 - 0.059 12.8 0.0 0.15 11.5 0.0 1.8 1 0 0 1 1 1 0 EF hand EF-hand_5 PF13202.4 200672.1_16125001_1 - 0.1 12.0 0.0 0.29 10.6 0.0 1.7 1 0 0 1 1 1 0 EF hand PROCN PF08083.9 200672.1_16125001_3 - 0.017 13.7 0.3 0.024 13.2 0.3 1.1 1 0 0 1 1 1 0 PROCN (NUC071) domain Period_C PF12114.6 182857.2_16129001_3 - 1.2e-73 246.7 4.6 1.2e-73 246.7 4.6 5.7 6 1 1 7 7 7 1 Period protein 2/3C-terminal region PAS_3 PF08447.10 182857.2_16129001_3 - 1.6e-12 47.4 0.0 2.1e-11 43.8 0.0 2.5 3 0 0 3 3 3 1 PAS fold PAS_11 PF14598.4 182857.2_16129001_3 - 4.7e-10 39.5 0.0 1.6e-09 37.8 0.0 1.9 2 0 0 2 2 2 1 PAS domain PAS PF00989.23 182857.2_16129001_3 - 2e-09 37.3 0.0 4.4e-07 29.8 0.0 2.6 2 0 0 2 2 2 2 PAS fold ABC2_membrane PF01061.22 001042775.1_16124001_1 - 4.7e-35 120.8 27.6 4.7e-35 120.8 27.6 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.25 001042775.1_16124001_1 - 1.4e-19 70.9 0.0 2.6e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 001042775.1_16124001_1 - 6.9e-06 26.0 1.8 0.059 13.0 0.3 2.6 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.17 001042775.1_16124001_1 - 4.4e-05 22.9 0.4 0.092 12.0 0.3 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.4 001042775.1_16124001_1 - 0.0019 18.6 0.6 0.005 17.2 0.6 1.6 1 0 0 1 1 1 1 AAA domain DUF87 PF01935.15 001042775.1_16124001_1 - 0.011 15.6 0.3 0.04 13.8 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_29 PF13555.4 001042775.1_16124001_1 - 0.017 14.7 0.1 0.042 13.4 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC2_membrane_3 PF12698.5 001042775.1_16124001_1 - 0.029 13.3 35.2 0.17 10.8 35.1 2.1 1 1 0 1 1 1 0 ABC-2 family transporter protein FtsK_SpoIIIE PF01580.16 001042775.1_16124001_1 - 0.15 11.3 0.1 0.28 10.4 0.1 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family GSHPx PF00255.17 001020501.1_16122001_1 - 3.5e-35 119.7 0.1 5e-35 119.2 0.1 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.19 001020501.1_16122001_1 - 7.1e-05 22.6 0.0 0.0006 19.6 0.0 2.0 1 1 0 1 1 1 1 AhpC/TSA family SCO1-SenC PF02630.12 001020501.1_16122001_1 - 0.023 14.4 0.0 1.9 8.2 0.0 2.3 2 0 0 2 2 2 0 SCO1/SenC Gp_dh_C PF02800.18 001115114.1_16123001_1 - 2.5e-67 225.3 0.0 3.9e-67 224.6 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.22 001115114.1_16123001_1 - 1.2e-38 131.4 0.2 2.7e-38 130.2 0.2 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.18 001115114.1_16123001_1 - 0.028 14.4 0.0 0.11 12.5 0.0 2.0 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus ABC2_membrane PF01061.22 001110454.1_16127001_3 - 2.8e-48 164.0 24.5 5.5e-48 163.0 24.5 1.5 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.25 001110454.1_16127001_3 - 2.1e-28 99.4 0.0 3.4e-28 98.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 001110454.1_16127001_3 - 2.1e-07 30.9 0.0 0.0011 18.8 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.17 001110454.1_16127001_3 - 1.9e-06 27.3 0.0 5e-06 26.0 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain DUF258 PF03193.14 001110454.1_16127001_3 - 0.00035 20.4 0.0 0.00061 19.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.4 001110454.1_16127001_3 - 0.012 15.1 0.6 0.025 14.1 0.6 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_13 PF13166.4 001110454.1_16127001_3 - 0.014 13.9 0.0 0.11 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.21 001110454.1_16127001_3 - 0.021 14.8 0.1 0.036 14.0 0.1 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.4 001110454.1_16127001_3 - 0.027 14.7 0.0 0.044 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 001110454.1_16127001_3 - 0.074 13.2 0.1 0.24 11.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.4 001110454.1_16127001_3 - 0.094 12.8 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.4 001110454.1_16127001_3 - 0.12 12.8 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.4 001110454.1_16127001_3 - 0.14 12.5 1.0 0.24 11.7 1.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.4 001110454.1_16127001_3 - 0.2 11.2 0.2 0.36 10.4 0.2 1.3 1 0 0 1 1 1 0 AAA domain ABC2_membrane_3 PF12698.5 001110454.1_16127001_3 - 0.35 9.8 28.4 0.065 12.2 23.7 2.0 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF1440 PF07274.10 001110454.1_16127001_3 - 0.63 10.3 4.9 6.4 7.0 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1440) EOS1 PF12326.6 001007353.1_16123001_3 - 1.6 8.5 4.5 14 5.4 1.7 2.1 2 0 0 2 2 2 0 N-glycosylation protein ABC2_membrane PF01061.22 001114569.2_16125001_1 - 6.1e-37 126.9 16.3 6.1e-37 126.9 16.3 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.25 001114569.2_16125001_1 - 3.3e-30 105.3 0.0 5.4e-30 104.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 001114569.2_16125001_1 - 3e-06 27.1 5.3 0.00098 18.9 0.2 2.5 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF258 PF03193.14 001114569.2_16125001_1 - 0.00092 19.0 0.0 0.0017 18.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.4 001114569.2_16125001_1 - 0.042 14.1 0.0 0.075 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.4 001114569.2_16125001_1 - 0.071 12.7 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.4 001114569.2_16125001_1 - 0.15 12.2 0.1 0.53 10.4 0.1 1.9 1 0 0 1 1 1 0 AAA domain Cadherin PF00028.15 131081.2_16129001_3 - 1.2e-84 278.7 0.9 2.6e-20 72.5 0.0 6.2 6 0 0 6 6 6 5 Cadherin domain Cadherin_C PF01049.15 131081.2_16129001_3 - 7.4e-51 171.8 0.3 1.3e-50 171.0 0.3 1.3 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_pro PF08758.9 131081.2_16129001_3 - 8.6e-21 73.8 0.1 2.5e-20 72.3 0.0 1.8 2 0 0 2 2 2 1 Cadherin prodomain like He_PIG PF05345.10 131081.2_16129001_3 - 0.00037 20.5 1.2 0.86 9.7 0.0 4.3 5 0 0 5 5 5 1 Putative Ig domain Cadherin_3 PF16184.3 131081.2_16129001_3 - 0.00067 19.5 6.6 0.31 10.9 0.1 5.1 5 0 0 5 5 5 1 Cadherin-like EphA2_TM PF14575.4 131081.2_16129001_3 - 0.0097 16.6 0.1 0.1 13.3 0.0 2.4 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain Rifin_STEVOR PF02009.14 131081.2_16129001_3 - 0.086 12.6 0.3 0.42 10.3 0.4 1.9 2 0 0 2 2 2 0 Rifin/stevor family YajC PF02699.13 131081.2_16129001_3 - 0.17 11.7 0.3 0.65 9.8 0.3 2.0 1 0 0 1 1 1 0 Preprotein translocase subunit CCER1 PF15482.4 131081.2_16129001_3 - 6 6.6 7.5 13 5.4 7.5 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 SRCR PF00530.16 001040041.1_16125001_1 - 2e-31 108.3 2.9 4.8e-31 107.1 2.9 1.7 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain BACK PF07707.13 001040041.1_16125001_1 - 3e-10 40.0 0.2 8.2e-10 38.6 0.2 1.7 1 0 0 1 1 1 1 BTB And C-terminal Kelch SRCR_2 PF15494.4 001040041.1_16125001_1 - 1.3e-05 25.5 0.2 3.6e-05 24.1 0.2 1.7 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain BTB PF00651.29 001040041.1_16125001_1 - 6.2e-05 23.0 0.2 0.00018 21.5 0.2 1.8 1 1 0 1 1 1 1 BTB/POZ domain SH2 PF00017.22 001076617.2_16123001_2 - 4.6e-10 39.3 0.0 7.8e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.14 001076617.2_16123001_2 - 1.1e-07 31.9 1.0 2.9e-07 30.6 1.0 1.7 1 0 0 1 1 1 1 SOCS box Forkhead PF00250.16 001076706.2_16128001_1 - 4.1e-35 119.8 0.2 7.3e-35 119.0 0.2 1.4 1 0 0 1 1 1 1 Forkhead domain MH2 PF03166.12 001290015.1_16128001_3 - 5.5e-79 264.6 0.1 7.8e-79 264.1 0.1 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 001290015.1_16128001_3 - 1.9e-42 143.5 1.2 3.5e-42 142.7 1.2 1.5 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.7 001290015.1_16128001_3 - 0.018 14.7 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 Interferon-regulatory factor 3 HPD PF05044.10 131405.2_16126001_1 - 8.9e-83 275.7 1.5 1.5e-82 274.9 1.5 1.4 1 0 0 1 1 1 1 Homeo-prospero domain NifQ PF04891.10 131405.2_16126001_1 - 0.053 13.7 1.2 0.36 11.0 0.0 2.5 2 0 0 2 2 2 0 NifQ Nop25 PF09805.7 131405.2_16126001_1 - 0.28 11.5 11.9 0.62 10.4 11.9 1.5 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Metal_resist PF13801.4 131405.2_16126001_1 - 2.1 8.4 12.6 0.67 10.0 8.2 2.4 3 0 0 3 3 3 0 Heavy-metal resistance IncA PF04156.12 131405.2_16126001_1 - 6 6.5 8.3 11 5.6 8.3 1.4 1 0 0 1 1 1 0 IncA protein Myb_DNA-bind_2 PF08914.9 001202416.1_16125001_2 - 2.3e-28 98.0 0.6 4.3e-28 97.2 0.6 1.4 1 0 0 1 1 1 1 Rap1 Myb domain BRCT_2 PF16589.3 001202416.1_16125001_2 - 2.2e-19 69.5 0.0 5.2e-19 68.3 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Rap1_C PF11626.6 001202416.1_16125001_2 - 2e-08 34.1 0.5 4e-07 29.9 0.1 2.4 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain bZIP_2 PF07716.13 131400.1_16126001_2 - 5e-16 58.4 12.7 5e-16 58.4 12.7 1.9 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.19 131400.1_16126001_2 - 7.1e-05 22.7 8.0 0.00013 21.8 8.0 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.15 131400.1_16126001_2 - 0.22 12.0 7.0 0.46 10.9 7.0 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor Plectin PF00681.18 001118897.1_16129001_3 - 1.3e-42 143.3 0.0 7.4e-11 41.6 0.1 6.8 5 1 2 7 7 7 5 Plectin repeat Spectrin PF00435.19 001118897.1_16129001_3 - 4.9e-05 23.6 4.4 4.9e-05 23.6 4.4 16.1 12 2 6 19 19 19 4 Spectrin repeat IKKbetaNEMObind PF12179.6 001118897.1_16129001_3 - 0.087 12.7 0.3 0.95 9.4 0.3 3.0 1 0 0 1 1 1 0 I-kappa-kinase-beta NEMO binding domain Motilin_assoc PF04643.10 001083872.1_16121001_1 - 2.9e-05 23.7 0.0 4.4e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Motilin/ghrelin-associated peptide SelP_N PF04592.12 001348769.1_23524001_3 - 1.3e-77 260.2 1.1 2.4e-77 259.4 1.1 1.4 1 1 0 1 1 1 1 Selenoprotein P, N terminal region Myb_DNA-binding PF00249.29 001309822.1_16127001_3 - 1.6e-54 181.7 18.3 1.2e-18 66.8 1.8 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 001309822.1_16127001_3 - 1.2e-40 137.4 16.9 1.6e-17 63.3 2.4 3.5 1 1 2 3 3 3 3 Myb-like DNA-binding domain Cmyb_C PF09316.8 001309822.1_16127001_3 - 1.4e-32 112.5 1.2 2.8e-32 111.5 1.2 1.5 1 0 0 1 1 1 1 C-myb, C-terminal LMSTEN PF07988.10 001309822.1_16127001_3 - 2.7e-26 90.6 0.3 4.9e-26 89.8 0.3 1.5 1 0 0 1 1 1 1 LMSTEN motif Myb_DNA-bind_7 PF15963.3 001309822.1_16127001_3 - 4e-09 36.1 7.2 0.00014 21.6 0.1 4.1 2 1 2 4 4 4 2 Myb DNA-binding like SLIDE PF09111.8 001309822.1_16127001_3 - 1.5e-05 24.8 0.4 1.9 8.4 0.0 3.5 1 1 2 3 3 3 3 SLIDE SANT_DAMP1_like PF16282.3 001309822.1_16127001_3 - 0.00062 19.8 3.5 0.59 10.2 0.0 3.3 1 1 2 3 3 3 1 SANT/Myb-like domain of DAMP1 Rap1_C PF11626.6 001309822.1_16127001_3 - 0.011 15.7 3.1 12 6.0 3.1 3.3 1 1 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Spore_III_AB PF09548.8 001309822.1_16127001_3 - 0.11 12.4 0.4 0.41 10.6 0.1 2.0 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) IRK_N PF08466.8 001309822.1_16127001_3 - 0.78 9.8 3.7 1.5 8.9 1.0 2.9 3 0 0 3 3 3 0 Inward rectifier potassium channel N-terminal ERM PF00769.17 001004296.1_16128001_3 - 2.2e-66 224.1 59.3 2.2e-66 224.1 59.3 2.9 2 1 1 3 3 3 1 Ezrin/radixin/moesin family FERM_C PF09380.8 001004296.1_16128001_3 - 7.1e-28 96.7 0.0 7.1e-28 96.7 0.0 2.3 2 0 0 2 2 2 1 FERM C-terminal PH-like domain FERM_M PF00373.16 001004296.1_16128001_3 - 5.6e-27 94.4 1.3 5.6e-27 94.4 1.3 3.2 3 0 0 3 3 3 1 FERM central domain FERM_N PF09379.8 001004296.1_16128001_3 - 1.9e-14 53.2 0.5 8.1e-14 51.2 0.1 2.2 2 0 0 2 2 2 1 FERM N-terminal domain Spore_YhaL PF14147.4 001004296.1_16128001_3 - 8.8 6.0 8.0 38 3.9 8.0 2.2 1 0 0 1 1 1 0 Sporulation protein YhaL C1q PF00386.19 212779.2_16127001_2 - 9.7e-26 90.3 0.2 1.3e-25 89.9 0.2 1.2 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 212779.2_16127001_2 - 0.00011 21.8 12.8 0.00019 21.0 12.8 1.3 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) An_peroxidase PF03098.13 212779.2_16127001_3 - 3.1e-179 596.8 0.0 3.7e-179 596.6 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase Lactamase_B_3 PF13483.4 001002192.1_16125001_3 - 1.5e-08 34.6 0.0 3.6e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.5 001002192.1_16125001_3 - 3.4e-06 26.6 0.1 7.8e-06 25.4 0.1 1.6 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Rieske PF00355.24 001002192.1_16125001_3 - 5.4e-06 26.1 0.3 1.2e-05 25.0 0.1 1.6 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain CSD PF00313.20 001126457.1_16124001_3 - 5.4e-26 90.1 1.1 8.2e-26 89.5 0.5 1.7 2 0 0 2 2 2 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.9 001126457.1_16124001_3 - 0.019 14.5 0.0 0.053 13.1 0.0 1.7 1 0 0 1 1 1 0 Ribonuclease B OB domain CH PF00307.29 131320.3_16125001_2 - 5.7e-90 296.7 0.2 2.9e-25 88.4 0.1 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_1 PF00036.30 131320.3_16125001_2 - 3.9e-14 50.9 0.6 4.6e-06 25.7 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 131320.3_16125001_2 - 5.6e-12 45.8 0.0 2.1e-11 44.0 0.0 2.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 131320.3_16125001_2 - 5.1e-11 41.5 0.4 2.9e-05 23.5 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 131320.3_16125001_2 - 1e-08 34.2 9.9 0.00031 20.0 0.1 3.9 4 1 1 5 5 5 2 EF hand EF-hand_8 PF13833.4 131320.3_16125001_2 - 1.9e-07 30.6 0.3 0.0029 17.2 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain pair CAMSAP_CH PF11971.6 131320.3_16125001_2 - 8.2e-05 22.2 0.0 0.00032 20.4 0.0 2.0 1 0 0 1 1 1 1 CAMSAP CH domain SPARC_Ca_bdg PF10591.7 131320.3_16125001_2 - 0.082 13.1 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region UT PF03253.12 001020519.1_16126001_2 - 3.7e-104 347.8 34.7 4.8e-104 347.4 34.7 1.1 1 0 0 1 1 1 1 Urea transporter Filament PF00038.19 001083105.1_16123001_2 - 8.3e-104 347.4 25.7 9.7e-104 347.1 25.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein DUF2461 PF09365.8 001083105.1_16123001_2 - 0.0052 16.6 2.6 0.01 15.7 0.1 2.5 2 1 1 3 3 3 1 Conserved hypothetical protein (DUF2461) Tweety PF04906.11 001083105.1_16123001_2 - 0.093 11.2 2.3 0.13 10.8 0.9 1.9 1 1 0 1 1 1 0 Tweety DUF972 PF06156.11 001083105.1_16123001_2 - 0.19 12.2 22.6 0.13 12.8 0.6 4.4 1 1 1 4 4 4 0 Protein of unknown function (DUF972) Reo_sigmaC PF04582.10 001083105.1_16123001_2 - 0.23 10.7 14.5 1 8.6 1.6 3.4 1 1 3 4 4 4 0 Reovirus sigma C capsid protein DUF745 PF05335.11 001083105.1_16123001_2 - 0.25 10.9 15.0 0.46 10.1 5.8 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF745) DUF1664 PF07889.10 001083105.1_16123001_2 - 0.98 9.3 15.8 0.82 9.5 1.4 3.8 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) ADIP PF11559.6 001083105.1_16123001_2 - 1.7 8.6 23.3 3.3 7.7 4.8 4.2 2 2 1 4 4 4 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.9 001083105.1_16123001_2 - 1.7 7.3 23.4 0.24 10.1 8.3 2.8 1 1 1 3 3 3 0 Spc7 kinetochore protein DivIC PF04977.13 001083105.1_16123001_2 - 1.8 8.3 17.1 3.8 7.2 0.1 4.6 4 0 0 4 4 4 0 Septum formation initiator APG6 PF04111.10 001083105.1_16123001_2 - 4.5 6.4 23.1 3 7.0 9.9 3.0 1 1 1 3 3 3 0 Autophagy protein Apg6 Prefoldin_2 PF01920.18 001083105.1_16123001_2 - 7.8 6.4 22.8 8.1 6.3 0.6 4.7 4 1 0 4 4 4 0 Prefoldin subunit Senescence PF06911.10 001113658.1_16125001_3 - 4e-48 163.8 6.9 6.1e-48 163.3 6.9 1.3 1 0 0 1 1 1 1 Senescence-associated protein MIT PF04212.16 001113658.1_16125001_3 - 3.3e-05 23.8 0.0 6.9e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TPR_1 PF00515.26 001113658.1_16125001_3 - 0.1 12.3 0.1 0.4 10.5 0.1 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat bZIP_2 PF07716.13 131885.2_16126001_2 - 8.5e-16 57.6 12.0 1.4e-15 57.0 12.0 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.19 131885.2_16126001_2 - 5e-05 23.2 7.1 9e-05 22.4 7.1 1.4 1 0 0 1 1 1 1 bZIP transcription factor Lipoprotein_20 PF13942.4 131885.2_16126001_2 - 0.015 15.1 1.3 0.025 14.4 1.3 1.2 1 0 0 1 1 1 0 YfhG lipoprotein SBE2 PF17076.3 131885.2_16126001_2 - 0.12 10.4 0.3 0.17 9.9 0.3 1.1 1 0 0 1 1 1 0 SBE2, cell-wall formation bZIP_Maf PF03131.15 131885.2_16126001_2 - 0.19 12.1 5.0 0.35 11.3 5.0 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF2514 PF10721.7 131885.2_16126001_2 - 0.2 11.5 1.2 0.43 10.5 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) zf-C2H2 PF00096.24 178296.3_16129001_1 - 3e-15 55.6 46.3 0.00042 20.5 1.4 7.6 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 178296.3_16129001_1 - 9.8e-10 38.3 9.4 1.2e-06 28.6 1.4 7.1 7 1 0 7 7 7 3 Zinc-finger double domain FOXP-CC PF16159.3 178296.3_16129001_1 - 0.0006 20.2 22.4 0.22 12.0 0.1 4.9 1 1 2 4 4 4 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.4 178296.3_16129001_1 - 0.0055 17.3 0.3 0.0055 17.3 0.3 8.3 8 0 0 8 8 8 3 C2H2-type zinc finger SAM_2 PF07647.15 001110398.1_16124001_3 - 6.5e-16 58.1 0.4 9.9e-16 57.5 0.4 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001110398.1_16124001_3 - 2.2e-07 31.1 0.2 4.7e-07 30.0 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 001110398.1_16124001_3 - 0.0003 20.6 0.1 0.00056 19.7 0.1 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Filament PF00038.19 131373.2_16126001_1 - 3.2e-112 375.0 39.8 3.9e-112 374.7 39.8 1.1 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.12 131373.2_16126001_1 - 4.9e-09 36.8 8.9 8.9e-09 36.0 8.9 1.4 1 0 0 1 1 1 1 Intermediate filament head (DNA binding) region Myosin_tail_1 PF01576.17 131373.2_16126001_1 - 4.6e-05 21.3 11.5 4.6e-05 21.3 11.5 2.1 1 1 1 2 2 2 1 Myosin tail DUF1664 PF07889.10 131373.2_16126001_1 - 0.0001 22.2 9.4 0.049 13.5 0.2 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF1664) Spc7 PF08317.9 131373.2_16126001_1 - 0.0021 16.9 33.1 0.15 10.8 15.6 2.9 1 1 2 3 3 3 3 Spc7 kinetochore protein Reo_sigmaC PF04582.10 131373.2_16126001_1 - 0.0031 16.8 2.7 0.46 9.7 0.1 2.7 1 1 2 3 3 3 2 Reovirus sigma C capsid protein DUF4515 PF14988.4 131373.2_16126001_1 - 0.0037 17.0 32.2 0.11 12.2 8.2 2.8 1 1 1 2 2 2 2 Domain of unknown function (DUF4515) TolA_bind_tri PF16331.3 131373.2_16126001_1 - 0.0073 16.2 3.0 0.0073 16.2 3.0 5.9 3 1 4 7 7 7 1 TolA binding protein trimerisation Golgin_A5 PF09787.7 131373.2_16126001_1 - 0.34 10.2 31.6 3.2 7.0 10.0 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 TPR_MLP1_2 PF07926.10 131373.2_16126001_1 - 0.69 9.8 37.6 1.1 9.2 11.6 4.1 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.7 131373.2_16126001_1 - 0.7 10.0 34.4 0.41 10.7 9.7 3.2 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 DUF5082 PF16888.3 131373.2_16126001_1 - 0.74 10.0 17.4 0.4 10.9 4.7 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) DUF1192 PF06698.9 131373.2_16126001_1 - 0.97 9.4 4.5 20 5.2 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Tektin PF03148.12 131373.2_16126001_1 - 1.1 7.9 29.2 0.017 13.7 11.4 2.8 1 1 1 3 3 3 0 Tektin family APG6 PF04111.10 131373.2_16126001_1 - 1.2 8.3 32.9 0.41 9.9 9.9 2.7 1 1 2 3 3 3 0 Autophagy protein Apg6 LURAP PF14854.4 131373.2_16126001_1 - 1.3 8.9 5.5 3 7.7 0.2 3.4 2 1 1 3 3 3 0 Leucine rich adaptor protein KLRAQ PF10205.7 131373.2_16126001_1 - 1.6 8.9 20.7 0.026 14.6 5.2 3.8 2 2 1 3 3 3 0 Predicted coiled-coil domain-containing protein Fib_alpha PF08702.8 131373.2_16126001_1 - 2.9 7.9 18.3 1.3 9.0 1.4 3.3 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family IncA PF04156.12 131373.2_16126001_1 - 4.1 7.0 37.6 1.4e+02 2.0 17.8 3.4 1 1 1 2 2 1 0 IncA protein DUF4200 PF13863.4 131373.2_16126001_1 - 6.9 6.9 32.6 48 4.2 11.0 3.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) IL17 PF06083.9 001020790.3_16123001_2 - 2.9e-26 91.6 0.3 2.9e-26 91.6 0.3 1.7 2 0 0 2 2 2 1 Interleukin-17 Rdx PF10262.7 194418.3_16123001_1 - 1.2e-10 41.3 0.0 3e-10 40.0 0.0 1.7 1 1 0 1 1 1 1 Rdx family adh_short PF00106.23 001002325.1_16123001_3 - 1.4e-35 122.4 0.0 8.1e-35 119.9 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001002325.1_16123001_3 - 8.4e-25 87.5 0.0 2.1e-24 86.2 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001002325.1_16123001_3 - 3.5e-08 33.4 0.1 5.8e-08 32.7 0.1 1.3 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.16 001002325.1_16123001_3 - 0.0096 16.0 0.1 0.018 15.2 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.19 001002325.1_16123001_3 - 0.044 13.1 0.1 0.096 12.0 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Aldedh PF00171.20 213301.2_16125001_1 - 1.1e-185 617.5 0.0 1.2e-185 617.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PAP2_C PF14360.4 001145563.1_16123001_2 - 1.6e-24 86.1 12.7 1.6e-24 86.1 12.7 2.3 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.19 001145563.1_16123001_2 - 8.6e-06 25.4 6.9 8.6e-06 25.4 6.9 1.7 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.4 001145563.1_16123001_2 - 0.36 10.4 18.7 0.21 11.1 13.8 2.2 2 1 0 2 2 2 0 PAP2 superfamily DUF308 PF03729.11 001145563.1_16123001_2 - 7.4 6.8 8.5 1.6 9.0 0.5 3.0 3 0 0 3 3 3 0 Short repeat of unknown function (DUF308) Aldedh PF00171.20 200490.1_16124001_2 - 1.1e-182 607.5 0.0 1.3e-182 607.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Pkinase_Tyr PF07714.15 152962.3_16127001_3 - 1.8e-102 341.9 0.0 2.7e-102 341.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 152962.3_16127001_3 - 2.4e-44 151.5 0.0 1.1e-43 149.4 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain I-set PF07679.14 152962.3_16127001_3 - 4.2e-41 138.8 0.0 1.4e-14 53.8 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 152962.3_16127001_3 - 8.8e-39 131.9 0.0 4e-12 46.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 152962.3_16127001_3 - 3.7e-28 97.4 0.6 5.9e-09 35.9 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 152962.3_16127001_3 - 2.6e-27 94.8 0.1 8.4e-11 41.9 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 152962.3_16127001_3 - 1.3e-15 57.3 2.9 0.00012 22.0 0.0 5.5 3 3 1 4 4 4 4 Immunoglobulin V-set domain Ig_5 PF16681.3 152962.3_16127001_3 - 1.9e-10 40.9 1.4 0.00036 20.8 0.2 4.0 3 1 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 152962.3_16127001_3 - 5.3e-05 23.1 0.2 0.012 15.6 0.0 3.2 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.3 152962.3_16127001_3 - 0.0037 17.4 1.0 0.58 10.4 0.1 3.7 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Pkinase_Tyr PF07714.15 204361.1_23529001_2 - 5.9e-103 343.5 0.0 8.4e-103 343.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 204361.1_23529001_2 - 6.3e-42 143.6 0.0 2.8e-30 105.5 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 204361.1_23529001_2 - 1.5e-28 99.1 7.7 1e-08 35.5 0.1 5.6 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.14 204361.1_23529001_2 - 1.4e-24 85.8 2.9 5.5e-09 35.8 0.1 5.5 5 0 0 5 5 5 4 Immunoglobulin I-set domain ig PF00047.23 204361.1_23529001_2 - 2.7e-15 56.2 11.5 3.4e-10 39.8 0.1 4.9 5 0 0 5 5 5 4 Immunoglobulin domain Ig_2 PF13895.4 204361.1_23529001_2 - 9.3e-11 41.8 3.3 0.00049 20.2 0.1 4.8 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 204361.1_23529001_2 - 6.3e-07 29.4 6.6 1.2 9.2 0.0 6.0 5 1 0 5 5 5 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 204361.1_23529001_2 - 0.009 15.9 0.1 1.4 8.9 0.1 2.7 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Cys_knot PF00007.20 205268.1_23524001_1 - 2.3e-16 59.9 12.4 2.3e-16 59.9 12.4 3.2 3 0 0 3 3 3 1 Cystine-knot domain VWC PF00093.16 205268.1_23524001_1 - 1.9e-11 43.9 8.6 1.9e-11 43.9 8.6 5.5 4 1 0 4 4 4 1 von Willebrand factor type C domain IGFBP PF00219.16 205268.1_23524001_1 - 3.3e-10 40.3 20.5 3.3e-10 40.3 20.5 5.7 4 2 2 6 6 6 1 Insulin-like growth factor binding protein TSP_1 PF00090.17 205268.1_23524001_1 - 0.0001 22.3 10.1 0.0001 22.3 10.1 2.7 2 0 0 2 2 2 1 Thrombospondin type 1 domain Orthoreo_P10 PF07204.9 001044665.1_23522001_1 - 0.039 13.8 0.1 0.064 13.1 0.1 1.3 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Lectin_C PF00059.19 001044665.1_23522001_3 - 1.1e-17 64.6 0.1 1.7e-17 64.0 0.1 1.3 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 001044665.1_23522001_3 - 6.5e-15 54.5 53.9 5e-09 35.7 23.9 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Ig_2 PF13895.4 001146140.1_23523001_1 - 1.3e-16 60.5 0.2 4.2e-09 36.5 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001146140.1_23523001_1 - 2.8e-13 50.2 0.1 7.8e-06 26.3 0.0 3.7 3 1 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 001146140.1_23523001_1 - 5.1e-08 32.9 0.3 0.0022 18.0 0.1 2.9 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001146140.1_23523001_1 - 4.2e-07 30.0 3.6 0.053 13.6 0.0 4.4 2 2 2 4 4 4 2 Immunoglobulin V-set domain SUR7 PF06687.10 001146140.1_23523001_1 - 0.0013 18.3 0.0 0.0016 18.0 0.0 1.2 1 0 0 1 1 1 1 SUR7/PalI family I-set PF07679.14 001146140.1_23523001_1 - 0.0084 16.0 0.0 2.2 8.3 0.0 2.8 2 1 0 2 2 2 1 Immunoglobulin I-set domain Ig_5 PF16681.3 001146140.1_23523001_1 - 0.088 13.1 0.3 0.25 11.6 0.0 1.8 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Rax2 PF12768.5 001146140.1_23523001_1 - 0.21 11.0 0.0 0.29 10.6 0.0 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF5011 PF16403.3 001146140.1_23523001_1 - 0.41 10.7 1.0 1.1 9.4 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5011) Pkinase_Tyr PF07714.15 205430.2_23527001_1 - 1.6e-97 325.8 0.0 2.2e-97 325.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.17 205430.2_23527001_1 - 6.3e-68 228.2 1.2 9e-68 227.7 0.1 1.8 2 0 0 2 2 2 1 Ephrin receptor ligand binding domain Pkinase PF00069.23 205430.2_23527001_1 - 2.7e-47 161.2 0.0 4.6e-47 160.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 205430.2_23527001_1 - 1.1e-34 118.5 1.4 4.3e-16 58.9 0.7 2.8 2 0 0 2 2 2 2 Fibronectin type III domain EphA2_TM PF14575.4 205430.2_23527001_1 - 2.5e-22 79.3 0.0 8.8e-22 77.6 0.0 2.0 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_1 PF00536.28 205430.2_23527001_1 - 3e-14 53.1 0.0 5.6e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 205430.2_23527001_1 - 4.2e-10 39.5 0.0 1.3e-09 37.9 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Pur_ac_phosph_N PF16656.3 205430.2_23527001_1 - 2.9e-08 34.0 0.6 9.9e-07 29.1 0.7 2.5 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Ephrin_rec_like PF07699.11 205430.2_23527001_1 - 4.9e-07 29.3 5.6 4.9e-07 29.3 5.6 2.8 2 1 1 3 3 3 1 Putative ephrin-receptor like fn3_2 PF16893.3 205430.2_23527001_1 - 7.6e-05 22.7 0.5 0.09 12.8 0.0 2.9 3 0 0 3 3 2 2 Fibronectin type III domain DUF2369 PF10179.7 205430.2_23527001_1 - 0.00039 20.7 1.8 0.17 12.3 0.1 2.5 1 1 1 2 2 2 2 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 205430.2_23527001_1 - 0.0018 18.5 0.1 0.036 14.3 0.1 2.8 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III DUF4998 PF16389.3 205430.2_23527001_1 - 0.0036 16.8 0.0 0.0073 15.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function Tissue_fac PF01108.15 205430.2_23527001_1 - 0.0041 16.8 0.4 1.3 8.7 0.1 2.5 2 0 0 2 2 2 1 Tissue factor TMEM154 PF15102.4 205430.2_23527001_1 - 0.0046 16.7 0.0 0.0086 15.9 0.0 1.4 1 0 0 1 1 1 1 TMEM154 protein family Kdo PF06293.12 205430.2_23527001_1 - 0.013 14.8 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Rax2 PF12768.5 205430.2_23527001_1 - 0.045 13.2 0.0 0.13 11.7 0.0 1.7 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF1934 PF09148.8 205430.2_23527001_1 - 0.11 12.4 0.4 0.24 11.3 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1934) SusE PF14292.4 205430.2_23527001_1 - 0.17 12.1 1.2 0.78 10.0 0.1 2.5 2 1 1 3 3 2 0 SusE outer membrane protein zinc_ribbon_5 PF13719.4 205430.2_23527001_1 - 7.2 6.3 11.0 13 5.5 2.3 3.2 3 0 0 3 3 3 0 zinc-ribbon domain Defensin_beta PF00711.17 001001194.1_23522001_1 - 8e-10 38.4 9.9 1.3e-09 37.8 9.9 1.3 1 0 0 1 1 1 1 Beta defensin Ig_2 PF13895.4 001318406.1_23522001_1 - 4.7e-16 58.8 0.0 8.3e-07 29.1 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001318406.1_23522001_1 - 1.2e-15 57.7 0.0 1.1e-06 29.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001318406.1_23522001_1 - 1.4e-09 37.8 0.2 3e-06 27.2 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001318406.1_23522001_1 - 3.4e-08 33.5 0.6 0.022 14.8 0.0 4.0 2 2 2 4 4 4 3 Immunoglobulin V-set domain I-set PF07679.14 001318406.1_23522001_1 - 1.9e-05 24.5 0.1 0.14 12.1 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin I-set domain Lep_receptor_Ig PF06328.9 001318406.1_23522001_1 - 0.0068 16.3 0.0 2.3 8.2 0.0 2.5 2 0 0 2 2 2 2 Ig-like C2-type domain Izumo-Ig PF16706.3 001318406.1_23522001_1 - 0.032 14.2 0.1 0.9 9.5 0.0 2.5 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Tissue_fac PF01108.15 001361095.1_37523001_3 - 4.6e-13 48.8 0.0 1.1e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.8 001361095.1_37523001_3 - 0.00073 19.7 0.0 0.0031 17.7 0.0 2.1 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.19 001361095.1_37523001_3 - 0.055 13.7 0.3 9.5 6.5 0.1 2.4 2 0 0 2 2 2 0 Fibronectin type III domain DUF3827 PF12877.5 001361095.1_37523001_3 - 0.23 9.7 0.0 0.29 9.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) 4HB_MCP_1 PF12729.5 001361095.1_37523001_3 - 0.43 10.0 0.7 0.78 9.1 0.7 1.3 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Neur_chan_LBD PF02931.21 204816.1_23523001_1 - 4.6e-72 241.8 2.2 5.9e-72 241.5 2.2 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 204816.1_23523001_1 - 2.3e-68 230.7 12.7 3.2e-52 177.8 10.3 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region DUF1129 PF06570.9 204816.1_23523001_1 - 0.26 10.7 8.6 0.8 9.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Claudin_2 PF13903.4 204816.1_23523001_1 - 1.3 8.7 5.1 2.2 7.9 2.7 2.2 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF2207 PF09972.7 204816.1_23523001_1 - 4.6 5.8 6.4 14 4.2 0.0 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) ANF_receptor PF01094.26 001111014.2_23529001_3 - 1.8e-59 201.5 0.0 2.9e-59 200.8 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 001111014.2_23529001_3 - 2.6e-58 196.0 0.1 4.8e-58 195.1 0.1 1.5 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 001111014.2_23529001_3 - 9.5e-46 154.6 0.1 2.1e-45 153.5 0.1 1.6 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001111014.2_23529001_3 - 2.6e-24 85.8 0.0 4.8e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.4 001111014.2_23529001_3 - 8.5e-06 25.6 0.0 5.8e-05 22.8 0.0 2.2 2 1 0 2 2 2 1 Periplasmic binding protein OAF PF14941.4 204500.1_23524001_2 - 7.5e-114 379.1 0.9 9.4e-114 378.7 0.9 1.1 1 0 0 1 1 1 1 Transcriptional regulator, Out at first TCR_zetazeta PF11628.6 206879.1_23524001_1 - 2.3e-16 59.0 0.4 3.8e-16 58.3 0.4 1.3 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 zeta chain ITAM PF02189.13 206879.1_23524001_1 - 2.4e-09 37.0 7.7 0.00029 21.0 0.0 4.0 4 0 0 4 4 4 3 Immunoreceptor tyrosine-based activation motif PIRT PF15099.4 206879.1_23524001_1 - 0.1 12.1 0.1 0.67 9.4 0.1 2.0 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family fn3 PF00041.19 205028.1_23523001_1 - 1e-06 28.9 0.2 1e-06 28.9 0.2 2.5 3 1 0 3 3 3 1 Fibronectin type III domain Ig_5 PF16681.3 205028.1_23523001_1 - 5.7e-06 26.5 0.1 1.2e-05 25.5 0.1 1.5 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_3 PF13927.4 205028.1_23523001_1 - 9.5e-06 26.0 0.7 0.00015 22.2 0.2 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 205028.1_23523001_1 - 6.1e-05 23.2 1.4 8.5e-05 22.7 0.2 1.9 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 205028.1_23523001_1 - 0.031 14.2 0.6 0.29 11.1 0.2 2.5 2 0 0 2 2 2 0 Immunoglobulin I-set domain IL12p40_C PF10420.7 205028.1_23523001_1 - 0.054 13.9 0.2 0.2 12.1 0.1 2.0 2 0 0 2 2 2 0 Cytokine interleukin-12p40 C-terminus Defensin_beta PF00711.17 001001609.2_23522001_2 - 2.3e-10 40.2 7.6 2.3e-10 40.2 7.6 2.0 2 0 0 2 2 2 1 Beta defensin ART PF01129.16 204855.1_23523001_1 - 1.2e-92 309.1 0.2 1.5e-92 308.8 0.2 1.1 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.12 204855.1_23523001_1 - 3.7e-05 23.0 0.0 5.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Cys_rich_FGFR PF00839.15 205496.1_23528001_3 - 4e-203 657.7 120.6 2.3e-17 62.8 1.8 16.3 16 0 0 16 16 16 16 Cysteine rich repeat IFT43 PF15305.4 205496.1_23528001_3 - 0.067 13.2 0.3 0.24 11.4 0.1 2.0 2 0 0 2 2 2 0 Intraflagellar transport protein 43 DUF445 PF04286.10 205496.1_23528001_3 - 0.73 9.5 6.8 3.3 7.3 5.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF445) Neur_chan_LBD PF02931.21 204181.2_23526001_3 - 6.7e-73 244.6 1.0 8.8e-73 244.2 1.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 204181.2_23526001_3 - 2.5e-65 220.7 0.0 3.5e-65 220.3 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region V-set_2 PF15910.3 001100288.1_23522001_2 - 3.3e-46 155.9 1.0 5.3e-46 155.2 1.0 1.3 1 0 0 1 1 1 1 ICOS V-set domain TMEM154 PF15102.4 001100288.1_23522001_2 - 0.018 14.8 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.4 001100288.1_23522001_2 - 0.17 12.6 0.2 0.49 11.1 0.1 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Ig_2 PF13895.4 001146141.1_23522001_1 - 5.8e-09 36.0 0.0 1.1e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001146141.1_23522001_1 - 9.4e-06 26.0 0.0 1.9e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001146141.1_23522001_1 - 1.9e-05 24.6 0.2 7.1e-05 22.8 0.0 2.0 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.15 001146141.1_23522001_1 - 0.0014 18.6 0.5 0.49 10.4 0.0 2.5 2 1 1 3 3 3 2 Immunoglobulin V-set domain Extensin-like_C PF06904.10 001146141.1_23522001_1 - 0.025 14.5 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 Extensin-like protein C-terminus Ig_4 PF16680.3 001146141.1_23522001_1 - 0.14 12.4 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain GDNF PF02351.14 205102.1_23527001_2 - 2.2e-37 127.7 50.0 4.3e-20 72.3 8.1 3.7 3 0 0 3 3 3 3 GDNF/GAS1 domain Ig_3 PF13927.4 001146137.1_23522001_1 - 2.5e-14 53.5 0.0 2.8e-06 27.7 0.0 2.8 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 001146137.1_23522001_1 - 5.2e-13 49.0 0.0 1.7e-07 31.4 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001146137.1_23522001_1 - 1.6e-07 31.2 0.0 0.00043 20.3 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001146137.1_23522001_1 - 1.5e-05 24.8 0.0 0.098 12.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.15 001146137.1_23522001_1 - 9.6e-05 22.4 0.8 0.09 12.8 0.0 3.2 2 2 0 2 2 2 2 Immunoglobulin V-set domain ProSAAS PF07259.10 001146137.1_23522001_1 - 0.046 13.5 0.4 0.56 10.0 0.0 2.1 2 0 0 2 2 2 0 ProSAAS precursor PsaL PF02605.13 001146137.1_23522001_1 - 0.056 12.9 0.0 0.095 12.2 0.0 1.3 1 0 0 1 1 1 0 Photosystem I reaction centre subunit XI SIT PF15330.4 001146137.1_23522001_1 - 0.089 13.1 0.0 0.24 11.7 0.0 1.6 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT V-set PF07686.15 205235.1_23523001_2 - 9.1e-11 41.8 0.1 1.6e-10 41.0 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 205235.1_23523001_2 - 3e-06 27.2 0.1 1.3e-05 25.2 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 205235.1_23523001_2 - 5.6e-06 26.7 0.0 2e-05 25.0 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 205235.1_23523001_2 - 0.00052 19.9 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain TMEM132D_C PF15706.3 205235.1_23523001_2 - 0.039 13.6 0.0 0.08 12.6 0.0 1.5 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term TMEM154 PF15102.4 205235.1_23523001_2 - 0.06 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.4 205235.1_23523001_2 - 0.15 12.7 0.0 0.52 11.0 0.0 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain C1-set PF07654.13 001037831.2_23523001_1 - 2.3e-33 114.4 3.0 5.5e-16 58.7 0.1 3.2 3 0 0 3 3 3 2 Immunoglobulin C1-set domain Ig_3 PF13927.4 001037831.2_23523001_1 - 6.4e-26 90.6 5.1 1.1e-10 41.9 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 001037831.2_23523001_1 - 6.4e-23 80.6 2.1 2.1e-09 37.3 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.10 001037831.2_23523001_1 - 2.3e-21 75.5 4.7 2.1e-09 37.2 0.1 3.2 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain I-set PF07679.14 001037831.2_23523001_1 - 1.1e-20 73.3 0.4 1.7e-09 37.5 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.4 001037831.2_23523001_1 - 1.1e-17 64.0 1.7 2.6e-06 27.6 0.1 3.6 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001037831.2_23523001_1 - 5.2e-15 55.4 0.9 2.6e-11 43.5 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin V-set domain IL4 PF00727.16 001007085.2_23521001_1 - 4.9e-08 33.1 0.1 7e-08 32.6 0.1 1.3 1 0 0 1 1 1 1 Interleukin 4 IL13 PF03487.11 001007085.2_23521001_1 - 5.8e-05 22.9 0.1 7.8e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 Interleukin-13 Lig_chan PF00060.24 001279550.1_37527001_1 - 1.8e-58 196.5 0.1 2.9e-58 195.8 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel ANF_receptor PF01094.26 001279550.1_37527001_1 - 1.5e-53 182.0 0.0 2.3e-53 181.4 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan-Glu_bd PF10613.7 001279550.1_37527001_1 - 6.7e-44 148.6 0.0 1.3e-43 147.7 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001279550.1_37527001_1 - 2.5e-22 79.3 0.0 5e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.4 001279550.1_37527001_1 - 0.0036 16.9 0.0 0.007 16.0 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein DUF2061 PF09834.7 001279550.1_37527001_1 - 0.091 13.1 0.2 0.28 11.6 0.2 1.9 1 0 0 1 1 1 0 Predicted membrane protein (DUF2061) Defensin_beta PF00711.17 001001193.1_23522001_3 - 9.5e-09 35.0 9.5 9.5e-09 35.0 9.5 1.6 2 0 0 2 2 2 1 Beta defensin P5-ATPase PF12409.6 001030881.1_23524001_1 - 7.2e-33 113.2 0.0 1.3e-32 112.4 0.0 1.4 1 0 0 1 1 1 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.18 001030881.1_23524001_1 - 2.3e-15 56.4 0.0 3.2e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_N PF00690.24 001030881.1_23524001_1 - 1.4e-06 27.7 0.0 2.5e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus E1-E2_ATPase PF00122.18 001030881.1_23524001_3 - 7.9e-16 57.9 0.6 1.1e-15 57.5 0.6 1.1 1 0 0 1 1 1 1 E1-E2 ATPase YjgP_YjgQ PF03739.12 001030881.1_23524001_3 - 0.025 13.3 1.8 0.034 12.9 1.8 1.1 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family MARVEL PF01284.21 001030881.1_23524001_3 - 0.067 13.1 0.4 0.11 12.4 0.4 1.3 1 0 0 1 1 1 0 Membrane-associating domain Vps54_N PF10475.7 001012854.2_23529001_3 - 1.3e-99 333.0 15.2 1.8e-98 329.3 15.2 2.5 1 1 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.7 001012854.2_23529001_3 - 1.7e-95 319.1 3.9 5e-95 317.6 3.9 1.8 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) DegS PF05384.9 001012854.2_23529001_3 - 0.39 10.1 3.4 3.8 6.8 0.3 2.5 2 0 0 2 2 2 0 Sensor protein DegS NUC173 PF08161.10 001012908.1_23529001_3 - 6.1e-77 257.7 0.0 6.1e-73 244.6 0.0 3.3 3 0 0 3 3 3 2 NUC173 domain CLASP_N PF12348.6 001012908.1_23529001_3 - 1.8 7.9 7.5 2 7.8 0.1 4.1 5 0 0 5 5 5 0 CLASP N terminal Ribosomal_L37 PF08561.8 001012908.1_23529001_3 - 3 8.2 7.0 8.6 6.8 7.0 1.7 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L37 CRIM PF16978.3 204826.1_23524001_1 - 1.2e-35 122.6 0.0 2.5e-35 121.6 0.0 1.5 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1 PF05422.10 204826.1_23524001_1 - 1.5e-32 113.0 12.5 1e-29 103.8 7.9 3.6 2 1 0 2 2 2 1 Stress-activated map kinase interacting protein 1 (SIN1) SIN1_PH PF16979.3 204826.1_23524001_1 - 4.6e-31 107.2 0.4 8.2e-31 106.4 0.4 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology LIM PF00412.20 131111.1_16124001_3 - 1.4e-23 82.7 19.2 1.7e-14 53.7 8.0 3.1 4 0 0 4 4 4 2 LIM domain HlyIII PF03006.18 183345.1_16123001_2 - 1.6e-54 184.9 17.2 1.6e-54 184.9 17.2 1.5 2 0 0 2 2 2 1 Haemolysin-III related Myosin_head PF00063.19 205163.1_23527001_3 - 1.4e-254 846.3 0.0 1.8e-254 846.0 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.11 205163.1_23527001_3 - 9.8e-40 136.1 0.0 2.6e-39 134.7 0.0 1.8 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.25 205163.1_23527001_3 - 1.4e-07 30.6 16.5 0.012 15.2 0.6 3.8 3 0 0 3 3 3 3 IQ calmodulin-binding motif AAA_16 PF13191.4 205163.1_23527001_3 - 0.015 15.5 0.1 0.05 13.8 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.4 205163.1_23527001_3 - 0.019 15.1 0.0 0.064 13.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.5 205163.1_23527001_3 - 0.13 11.1 0.0 0.23 10.2 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain Zeta_toxin PF06414.10 205163.1_23527001_3 - 0.15 11.2 0.0 0.3 10.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Glyco_transf_29 PF00777.16 205233.1_23525001_1 - 6.7e-68 228.8 0.0 8.4e-68 228.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Myotub-related PF06602.12 200394.1_16125001_3 - 7.7e-143 475.4 0.2 9.8e-143 475.1 0.2 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.25 200394.1_16125001_3 - 0.0026 17.2 0.3 0.0085 15.5 0.0 1.9 2 0 0 2 2 2 1 Protein-tyrosine phosphatase GRAM PF02893.18 200394.1_16125001_3 - 0.0056 16.4 0.2 0.012 15.3 0.0 1.6 2 0 0 2 2 2 1 GRAM domain Vps36_ESCRT-II PF11605.6 200394.1_16125001_3 - 0.0076 16.3 0.2 0.018 15.1 0.2 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 Y_phosphatase3 PF13350.4 200394.1_16125001_3 - 0.025 14.4 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family DSPc PF00782.18 200394.1_16125001_3 - 0.039 13.6 0.0 0.08 12.6 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain zf-C2H2 PF00096.24 205049.1_23529001_2 - 4.1e-40 133.9 123.6 8.4e-05 22.7 2.5 16.3 16 0 0 16 16 16 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 205049.1_23529001_2 - 1.8e-36 121.5 116.6 0.00046 20.6 1.1 16.1 16 0 0 16 16 16 13 C2H2-type zinc finger zf-H2C2_2 PF13465.4 205049.1_23529001_2 - 2.6e-26 90.7 116.2 6.1e-08 32.6 1.1 19.0 20 0 0 20 20 20 7 Zinc-finger double domain zf-C2H2_6 PF13912.4 205049.1_23529001_2 - 1.1e-08 34.7 94.6 6.7e-06 25.8 0.2 15.1 17 0 0 17 17 17 8 C2H2-type zinc finger zf-met PF12874.5 205049.1_23529001_2 - 3.3e-08 33.5 77.7 0.022 15.0 0.7 13.2 13 0 0 13 13 13 7 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.4 205049.1_23529001_2 - 2.5e-07 30.2 0.0 2.5e-07 30.2 0.0 11.9 14 0 0 14 14 14 6 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.3 205049.1_23529001_2 - 6.3e-05 23.1 38.6 0.0063 16.7 0.5 6.2 6 0 0 6 6 6 3 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.6 205049.1_23529001_2 - 0.00055 20.0 65.4 0.06 13.5 1.5 12.9 15 0 0 15 15 15 6 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 205049.1_23529001_2 - 0.0046 17.1 5.0 0.0046 17.1 5.0 9.1 8 3 2 10 10 10 5 Drought induced 19 protein (Di19), zinc-binding Vps26 PF03643.13 001002415.2_16123001_1 - 2.6e-131 436.5 6.2 3.2e-131 436.2 6.2 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.27 001002415.2_16123001_1 - 0.012 15.6 1.0 3.2 7.7 0.2 3.1 2 1 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain Arm PF00514.21 001079683.1_16126001_2 - 1.7e-20 72.2 25.6 0.00093 19.0 0.3 12.0 11 1 2 13 13 13 6 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 001079683.1_16126001_2 - 1.7e-10 41.0 7.7 0.00068 19.9 0.1 8.0 9 1 1 10 10 10 3 HEAT-like repeat HEAT PF02985.20 001079683.1_16126001_2 - 3.7e-09 35.9 9.9 0.05 13.7 0.1 7.9 8 0 0 8 8 7 2 HEAT repeat HEAT_2 PF13646.4 001079683.1_16126001_2 - 1.7e-07 31.4 0.8 1.1 9.5 0.0 6.5 4 1 4 8 8 8 2 HEAT repeats DUF383 PF04063.12 001079683.1_16126001_2 - 0.00015 21.4 4.7 0.057 13.0 0.5 3.6 2 2 2 4 4 4 2 Domain of unknown function (DUF383) V-ATPase_H_C PF11698.6 001079683.1_16126001_2 - 0.00043 20.3 4.2 0.97 9.4 0.0 5.1 2 1 4 6 6 6 1 V-ATPase subunit H Uso1_p115_head PF04869.12 001079683.1_16126001_2 - 0.00095 18.3 2.6 0.26 10.2 0.2 3.4 2 1 1 3 3 3 2 Uso1 / p115 like vesicle tethering protein, head region IFRD PF05004.11 001079683.1_16126001_2 - 0.0015 17.5 13.9 0.012 14.6 2.7 4.1 1 1 3 4 4 4 2 Interferon-related developmental regulator (IFRD) UNC45-central PF11701.6 001079683.1_16126001_2 - 0.0035 17.2 7.6 1.7 8.5 0.5 4.2 2 1 2 4 4 4 2 Myosin-binding striated muscle assembly central Cnd1 PF12717.5 001079683.1_16126001_2 - 0.021 14.7 11.6 0.85 9.5 0.4 4.5 2 2 2 4 4 4 0 non-SMC mitotic condensation complex subunit 1 RTTN_N PF14726.4 001079683.1_16126001_2 - 0.04 14.6 3.4 48 4.8 0.0 4.5 3 1 1 4 4 4 0 Rotatin, an armadillo repeat protein, centriole functioning ParcG PF10274.7 001079683.1_16126001_2 - 0.089 12.8 0.6 0.53 10.2 0.2 2.4 2 0 0 2 2 2 0 Parkin co-regulated protein RICTOR_V PF14668.4 001079683.1_16126001_2 - 0.19 11.8 3.1 12 6.1 0.0 4.8 4 1 1 5 5 5 0 Rapamycin-insensitive companion of mTOR, domain 5 Aminotran_1_2 PF00155.19 001018012.1_23525001_1 - 1.4e-78 264.4 0.0 2e-78 264.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Preseq_ALAS PF09029.8 001018012.1_23525001_1 - 6.6e-45 152.2 7.8 1.3e-44 151.2 7.8 1.5 1 0 0 1 1 1 1 5-aminolevulinate synthase presequence Cys_Met_Meta_PP PF01053.18 001018012.1_23525001_1 - 2.5e-07 29.4 0.0 1.4e-06 27.0 0.0 1.9 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.17 001018012.1_23525001_1 - 2.3e-05 23.4 0.0 4.1e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.19 001018012.1_23525001_1 - 0.00055 19.2 0.0 0.001 18.3 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.15 001018012.1_23525001_1 - 0.013 14.7 0.6 0.052 12.7 0.6 1.8 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Carn_acyltransf PF00755.18 001130719.1_16124001_1 - 1.1e-193 644.9 0.0 1.3e-193 644.7 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Peptidase_C93 PF06035.9 001130719.1_16124001_1 - 0.018 14.7 0.7 0.12 12.0 0.3 2.1 2 0 0 2 2 2 0 Bacterial transglutaminase-like cysteine proteinase BTLCP E1-E2_ATPase PF00122.18 205475.1_23527001_1 - 1.6e-57 194.2 2.6 3.5e-57 193.1 2.6 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 205475.1_23527001_1 - 1.7e-44 151.6 3.0 2.2e-44 151.2 0.2 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 205475.1_23527001_1 - 1.5e-25 89.0 0.0 3.6e-25 87.7 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 205475.1_23527001_1 - 3.5e-19 69.8 0.1 6.9e-10 39.4 0.0 2.9 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 205475.1_23527001_1 - 1.6e-18 65.9 0.0 3.1e-18 65.0 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 205475.1_23527001_1 - 1.1e-05 25.2 0.6 0.0016 18.1 0.3 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Tropomyosin PF00261.18 205446.1_23523001_3 - 5.4e-92 307.3 63.7 6.3e-92 307.1 63.7 1.0 1 0 0 1 1 1 1 Tropomyosin Tropomyosin_1 PF12718.5 205446.1_23523001_3 - 2.5e-24 85.9 60.4 2.9e-19 69.5 29.2 3.5 1 1 2 3 3 3 3 Tropomyosin like HrpB7 PF09486.8 205446.1_23523001_3 - 0.0013 19.0 43.5 0.002 18.4 18.3 3.2 2 1 1 3 3 3 1 Bacterial type III secretion protein (HrpB7) YscO PF07321.10 205446.1_23523001_3 - 0.0092 15.8 2.4 0.0092 15.8 2.4 4.0 1 1 3 4 4 4 2 Type III secretion protein YscO Laminin_II PF06009.10 205446.1_23523001_3 - 0.0093 15.9 27.6 0.041 13.7 2.1 3.5 1 1 2 3 3 3 2 Laminin Domain II SlyX PF04102.10 205446.1_23523001_3 - 0.035 14.6 0.4 0.035 14.6 0.4 5.1 2 2 3 5 5 5 0 SlyX Reo_sigmaC PF04582.10 205446.1_23523001_3 - 0.074 12.3 4.0 0.27 10.4 0.9 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein HOOK PF05622.10 205446.1_23523001_3 - 0.097 10.7 42.2 0.12 10.3 42.2 1.1 1 0 0 1 1 1 0 HOOK protein Fib_alpha PF08702.8 205446.1_23523001_3 - 0.24 11.5 23.3 0.053 13.6 6.2 2.5 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family MscS_porin PF12795.5 205446.1_23523001_3 - 0.36 10.2 40.8 0.15 11.4 31.3 2.3 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain IncA PF04156.12 205446.1_23523001_3 - 0.42 10.2 52.2 0.099 12.3 17.6 2.9 1 1 1 2 2 2 0 IncA protein TB PF00683.15 205446.1_23523001_3 - 0.46 10.1 4.3 0.2 11.2 0.5 2.3 2 0 0 2 2 2 0 TB domain DUF16 PF01519.14 205446.1_23523001_3 - 0.54 10.6 33.4 0.21 11.9 2.5 4.0 1 1 3 4 4 4 0 Protein of unknown function DUF16 CLZ PF16526.3 205446.1_23523001_3 - 0.58 10.4 37.2 0.31 11.3 4.7 4.4 2 2 2 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels SNARE PF05739.17 205446.1_23523001_3 - 0.9 9.5 3.4 3 7.8 0.1 2.9 3 0 0 3 3 3 0 SNARE domain XhlA PF10779.7 205446.1_23523001_3 - 1.2 9.3 38.2 0.56 10.3 0.8 5.8 3 2 3 6 6 6 0 Haemolysin XhlA Golgin_A5 PF09787.7 205446.1_23523001_3 - 1.2 8.3 48.2 0.64 9.3 19.8 2.7 1 1 2 3 3 2 0 Golgin subfamily A member 5 EzrA PF06160.10 205446.1_23523001_3 - 1.8 6.5 44.4 0.54 8.3 8.1 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA CENP-F_leu_zip PF10473.7 205446.1_23523001_3 - 2.4 8.0 55.2 1.4 8.8 30.8 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_DNA_bd PF12329.6 205446.1_23523001_3 - 3.3 7.6 50.7 0.027 14.3 12.6 5.0 2 1 1 4 4 3 0 TATA element modulatory factor 1 DNA binding BST2 PF16716.3 205446.1_23523001_3 - 5 7.6 33.8 0.17 12.3 6.6 3.6 1 1 3 4 4 4 0 Bone marrow stromal antigen 2 ATG16 PF08614.9 205446.1_23523001_3 - 5.1 7.1 53.0 2.9 7.9 7.8 3.1 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) HR1 PF02185.14 205446.1_23523001_3 - 6.7 6.8 37.8 0.46 10.5 12.7 4.6 2 1 1 4 4 4 0 Hr1 repeat Snapin_Pallidin PF14712.4 205446.1_23523001_3 - 8.9 6.7 26.0 4.5 7.7 0.0 4.8 2 1 3 5 5 5 0 Snapin/Pallidin DUF1664 PF07889.10 205446.1_23523001_3 - 9 6.2 25.1 2.9 7.8 2.8 3.5 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) C1-set PF07654.13 001001750.1_23521001_3 - 1.1e-21 77.0 0.0 1.3e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001001750.1_23521001_3 - 1.8e-05 25.2 0.0 2.4e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001001750.1_23521001_3 - 0.00017 21.4 0.0 0.00024 21.0 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin I-set domain C2-set_2 PF08205.10 001001750.1_23521001_3 - 0.003 17.5 0.0 0.0038 17.1 0.0 1.1 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001001750.1_23521001_3 - 0.058 13.4 0.0 0.086 12.9 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin domain bZIP_Maf PF03131.15 205025.1_23525001_1 - 2.8e-33 114.2 12.3 5.2e-33 113.3 12.3 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor Maf_N PF08383.9 205025.1_23525001_1 - 2e-20 72.1 2.0 4.2e-20 71.1 2.0 1.6 1 0 0 1 1 1 1 Maf N-terminal region bZIP_1 PF00170.19 205025.1_23525001_1 - 0.0013 18.7 12.8 0.0041 17.1 12.8 1.9 1 0 0 1 1 1 1 bZIP transcription factor DUF737 PF05300.9 205025.1_23525001_1 - 0.0044 17.3 0.5 0.0065 16.7 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF737) HOOK PF05622.10 205025.1_23525001_1 - 0.0048 15.0 7.6 0.0065 14.6 7.6 1.0 1 0 0 1 1 1 1 HOOK protein DUF1192 PF06698.9 205025.1_23525001_1 - 0.14 12.1 1.2 16 5.5 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) DUF2353 PF09789.7 205025.1_23525001_1 - 0.28 10.4 9.0 0.38 10.0 9.0 1.1 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) DUF342 PF03961.11 205025.1_23525001_1 - 0.34 9.3 3.8 0.47 8.9 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) E1-E2_ATPase PF00122.18 205476.1_23527001_1 - 3.8e-58 196.3 1.6 3.8e-58 196.3 1.6 1.7 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 205476.1_23527001_1 - 5.9e-44 149.8 2.5 1e-43 149.0 0.1 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 205476.1_23527001_1 - 7.5e-24 83.5 0.0 1.8e-23 82.3 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 205476.1_23527001_1 - 3.4e-19 69.8 0.0 1.1e-09 38.8 0.0 2.8 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 205476.1_23527001_1 - 1.2e-17 63.2 0.0 2.2e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 205476.1_23527001_1 - 1.3e-05 24.9 1.1 0.0014 18.3 0.5 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Sigma70_r4 PF04545.14 205476.1_23527001_1 - 0.01 15.2 0.0 0.3 10.5 0.0 2.9 3 0 0 3 3 3 0 Sigma-70, region 4 DBR1 PF05011.11 001031566.1_23526001_3 - 6.2e-35 120.5 0.3 1e-34 119.8 0.3 1.4 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.26 001031566.1_23526001_3 - 2.3e-10 41.2 0.2 3.5e-10 40.6 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.5 001031566.1_23526001_3 - 0.00068 19.8 0.0 0.0017 18.5 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Requiem_N PF14051.4 204331.1_23523001_2 - 3.2e-36 123.2 1.4 5.9e-36 122.4 1.4 1.5 1 0 0 1 1 1 1 N-terminal domain of DPF2/REQ. PHD PF00628.27 204331.1_23523001_2 - 1.3e-20 72.9 20.5 1.4e-11 44.0 7.5 2.6 1 1 1 2 2 2 2 PHD-finger PHD_4 PF16866.3 204331.1_23523001_2 - 0.0094 15.9 8.2 0.0094 15.9 8.2 2.9 1 1 1 2 2 2 1 PHD-finger Lar_restr_allev PF14354.4 204331.1_23523001_2 - 0.018 15.3 1.1 0.018 15.3 1.1 3.1 2 1 1 3 3 3 0 Restriction alleviation protein Lar PHD_2 PF13831.4 204331.1_23523001_2 - 0.61 9.5 17.3 0.041 13.3 1.0 3.0 2 1 0 2 2 2 0 PHD-finger zf-PHD-like PF15446.4 204331.1_23523001_2 - 3.8 7.0 17.9 0.19 11.2 2.7 3.3 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain Dynamin_M PF01031.18 200922.1_16125001_3 - 9e-102 340.0 0.1 2.2e-101 338.7 0.0 1.7 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.21 200922.1_16125001_3 - 1.3e-56 191.2 0.6 3.5e-56 189.7 0.1 1.9 2 0 0 2 2 2 1 Dynamin family GED PF02212.16 200922.1_16125001_3 - 7e-33 112.5 1.7 1.9e-32 111.1 1.7 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.21 200922.1_16125001_3 - 7.9e-06 25.8 0.5 3.8e-05 23.6 0.3 2.3 3 1 0 3 3 3 1 50S ribosome-binding GTPase AAA_16 PF13191.4 200922.1_16125001_3 - 0.083 13.1 0.1 0.74 10.0 0.0 2.5 3 0 0 3 3 3 0 AAA ATPase domain Bromo_TP PF07524.11 001030841.2_23528001_2 - 4.4e-18 64.9 0.0 6.9e-18 64.3 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated PHD PF00628.27 001030841.2_23528001_2 - 4.8e-11 42.2 7.3 1.6e-10 40.6 7.3 2.0 1 0 0 1 1 1 1 PHD-finger RNA_pol_Rpc4 PF05132.12 001030841.2_23528001_2 - 0.0058 17.0 13.9 0.0058 17.0 13.9 5.7 5 1 0 5 5 5 1 RNA polymerase III RPC4 PHD_2 PF13831.4 001030841.2_23528001_2 - 0.0093 15.3 1.7 0.0093 15.3 1.7 1.9 2 0 0 2 2 2 1 PHD-finger Gti1_Pac2 PF09729.7 001030841.2_23528001_2 - 0.017 15.0 0.1 0.017 15.0 0.1 3.7 3 1 0 3 3 3 0 Gti1/Pac2 family Pkinase_Tyr PF07714.15 131053.1_16128001_2 - 2.3e-103 344.9 0.0 3.7e-103 344.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 131053.1_16128001_2 - 3e-43 147.9 0.0 2.1e-30 105.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 131053.1_16128001_2 - 8.9e-33 112.6 17.5 3.4e-10 40.3 0.4 5.8 5 1 0 5 5 5 5 Immunoglobulin domain I-set PF07679.14 131053.1_16128001_2 - 4.5e-21 74.6 2.3 1.4e-06 28.2 0.0 6.0 6 0 0 6 6 6 4 Immunoglobulin I-set domain ig PF00047.23 131053.1_16128001_2 - 2.1e-19 69.3 6.8 1.2e-09 38.1 0.2 4.7 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.4 131053.1_16128001_2 - 4.8e-15 55.5 16.6 8.9e-08 32.2 0.2 6.1 4 1 2 6 6 6 2 Immunoglobulin domain V-set PF07686.15 131053.1_16128001_2 - 3.8e-05 23.7 11.2 0.12 12.4 0.4 6.3 5 2 0 5 5 5 2 Immunoglobulin V-set domain C1-set PF07654.13 131053.1_16128001_2 - 0.00074 19.8 1.5 0.23 11.8 0.1 3.5 3 0 0 3 3 3 1 Immunoglobulin C1-set domain C2-set_2 PF08205.10 131053.1_16128001_2 - 0.0021 17.9 7.8 0.14 12.1 0.1 4.4 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 131053.1_16128001_2 - 0.0058 16.9 1.7 0.22 11.8 0.1 3.3 2 1 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 131053.1_16128001_2 - 0.034 14.1 0.7 1.9 8.5 0.0 3.1 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Ig_4 PF16680.3 131053.1_16128001_2 - 0.036 14.3 0.5 0.036 14.3 0.5 4.1 5 1 0 5 5 4 0 T-cell surface glycoprotein CD3 delta chain Thiolase_N PF00108.21 001003746.1_16124001_1 - 1.2e-94 316.3 1.3 1.7e-94 315.9 1.3 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 001003746.1_16124001_1 - 6.1e-45 151.7 2.0 1.6e-44 150.4 1.0 2.0 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.24 001003746.1_16124001_1 - 2.3e-05 23.9 1.4 2.3e-05 23.9 1.4 2.1 2 1 1 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Synaptobrevin PF00957.19 001031121.1_23526001_3 - 1.2e-29 101.7 2.5 1.9e-29 101.2 2.5 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.4 001031121.1_23526001_3 - 2.2e-26 91.5 0.7 4.3e-26 90.6 0.7 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Hox9_act PF04617.11 131126.3_16123001_1 - 8.8e-63 212.3 10.2 1.2e-62 211.9 10.2 1.2 1 0 0 1 1 1 1 Hox9 activation region Homeobox PF00046.27 131126.3_16123001_1 - 3.1e-20 71.6 5.7 5e-20 71.0 5.7 1.3 1 0 0 1 1 1 1 Homeobox domain HTH_23 PF13384.4 131126.3_16123001_1 - 0.042 13.5 0.1 0.081 12.6 0.1 1.4 1 0 0 1 1 1 0 Homeodomain-like domain TUDOR PF00567.22 001164028.1_16129001_1 - 6.1e-111 365.1 3.1 2.6e-29 101.6 0.0 4.8 4 0 0 4 4 4 4 Tudor domain SMN PF06003.10 001164028.1_16129001_1 - 1.3e-18 67.0 4.7 8e-06 25.2 0.0 4.8 5 0 0 5 5 5 4 Survival motor neuron protein (SMN) Agenet PF05641.10 001164028.1_16129001_1 - 3e-10 40.3 0.5 0.18 12.2 0.0 4.6 4 0 0 4 4 4 4 Agenet domain zf-MYND PF01753.16 001164028.1_16129001_1 - 1.5e-06 28.1 20.8 1.5e-06 28.1 20.8 3.0 3 0 0 3 3 3 1 MYND finger DUF4537 PF15057.4 001164028.1_16129001_1 - 0.014 15.2 0.0 14 5.6 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4537) Trimer_CC PF08954.9 001164028.1_16129001_1 - 1.9 8.0 3.6 1.5 8.3 0.1 2.4 2 0 0 2 2 2 0 Trimerisation motif Homeobox PF00046.27 001126486.1_16123001_1 - 1.1e-18 66.7 8.7 1.9e-18 65.9 8.7 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001126486.1_16123001_1 - 0.07 12.9 1.2 0.15 11.9 1.2 1.5 1 0 0 1 1 1 0 Homeobox KN domain Homez PF11569.6 001126486.1_16123001_1 - 0.072 12.4 0.4 0.17 11.3 0.4 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez LIM PF00412.20 001020739.2_16124001_2 - 1.4e-28 98.7 22.3 3.8e-14 52.5 8.1 2.6 2 0 0 2 2 2 2 LIM domain SPC12 PF06645.11 001171645.1_23522001_2 - 1.7e-31 108.0 1.6 2.3e-31 107.5 1.6 1.2 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) SDA1 PF05285.10 001171645.1_23522001_2 - 0.00026 20.4 0.4 0.00026 20.4 0.4 1.1 1 0 0 1 1 1 1 SDA1 TRAP_alpha PF03896.14 001171645.1_23522001_2 - 0.005 16.0 0.8 0.0076 15.4 0.8 1.3 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Tim54 PF11711.6 001171645.1_23522001_2 - 0.0062 15.2 2.5 0.0083 14.8 2.5 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 BSP_II PF05432.9 001171645.1_23522001_2 - 0.0075 15.9 10.6 0.0093 15.6 10.6 1.1 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) RNA_pol_Rpc4 PF05132.12 001171645.1_23522001_2 - 0.016 15.5 0.7 0.018 15.3 0.0 1.5 2 0 0 2 2 1 0 RNA polymerase III RPC4 Plasmodium_Vir PF05795.9 001171645.1_23522001_2 - 0.028 13.7 0.5 0.037 13.3 0.5 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF1510 PF07423.9 001171645.1_23522001_2 - 0.039 13.3 8.5 0.057 12.7 8.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) OATP PF03137.18 001171645.1_23522001_2 - 0.061 11.5 0.0 0.08 11.1 0.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF913 PF06025.10 001171645.1_23522001_2 - 0.086 11.7 0.1 0.096 11.5 0.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.20 001171645.1_23522001_2 - 0.095 11.8 0.1 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RabGAP-TBC PF00566.16 001171645.1_23522001_2 - 0.11 12.0 0.1 0.14 11.6 0.1 1.1 1 0 0 1 1 1 0 Rab-GTPase-TBC domain Connexin PF00029.17 001171645.1_23522001_2 - 0.12 12.0 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Connexin DUF719 PF05334.11 001171645.1_23522001_2 - 0.2 11.7 4.9 0.27 11.3 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF719) CPSF100_C PF13299.4 001171645.1_23522001_2 - 0.21 11.6 4.4 0.3 11.1 4.4 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Usp PF00582.24 001171645.1_23522001_2 - 0.41 11.0 3.4 0.73 10.2 3.4 1.4 1 0 0 1 1 1 0 Universal stress protein family Astro_capsid_p PF12226.6 001171645.1_23522001_2 - 0.56 9.2 6.8 0.71 8.8 6.8 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RR_TM4-6 PF06459.10 001171645.1_23522001_2 - 0.94 9.1 8.6 1.3 8.7 8.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GNAT_acetyltr_2 PF13718.4 001171645.1_23522001_2 - 1 8.6 4.9 1.5 8.0 4.9 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 TFB6 PF17110.3 001171645.1_23522001_2 - 1.5 8.4 4.4 2.1 7.9 4.4 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DNA_pol_phi PF04931.11 001171645.1_23522001_2 - 2.1 6.2 13.5 2.6 5.9 13.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi CobT PF06213.10 001171645.1_23522001_2 - 2.1 7.5 16.0 2.9 7.1 16.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nop14 PF04147.10 001171645.1_23522001_2 - 2.4 6.1 13.1 2.9 5.9 13.1 1.0 1 0 0 1 1 1 0 Nop14-like family Roughex PF06020.9 001171645.1_23522001_2 - 2.5 7.0 8.5 3.4 6.5 8.5 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Pox_Ag35 PF03286.12 001171645.1_23522001_2 - 2.7 7.6 9.2 4.5 6.9 9.2 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CDC45 PF02724.12 001171645.1_23522001_2 - 3.9 5.5 9.6 4.8 5.2 9.6 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM117 PF15388.4 001012855.2_23529001_1 - 5.9e-126 419.8 20.1 5.9e-126 419.8 20.1 2.2 2 0 0 2 2 2 1 Protein Family FAM117 zf-C2H2_2 PF12756.5 001195469.1_23523001_3 - 3.3e-44 149.2 23.6 1.3e-21 76.7 6.0 3.3 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.4 001195469.1_23523001_3 - 6e-11 42.1 22.2 0.0017 18.9 0.5 5.7 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001195469.1_23523001_3 - 6.6e-05 23.0 2.6 6.6e-05 23.0 2.6 4.2 4 1 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.24 001195469.1_23523001_3 - 0.00023 21.3 26.6 0.00055 20.1 1.6 5.6 5 1 0 5 5 5 2 Zinc finger, C2H2 type zf-met PF12874.5 001195469.1_23523001_3 - 0.0029 17.8 5.8 0.045 14.0 1.6 3.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-BED PF02892.13 001195469.1_23523001_3 - 0.0032 17.4 23.6 0.0083 16.0 1.3 5.1 5 0 0 5 5 5 2 BED zinc finger zf-C2H2_11 PF16622.3 001195469.1_23523001_3 - 0.031 13.9 5.9 2.3 7.9 0.1 3.7 3 0 0 3 3 3 0 zinc-finger C2H2-type YokU PF14122.4 001195469.1_23523001_3 - 0.045 13.6 0.0 0.045 13.6 0.0 2.5 3 0 0 3 3 3 0 YokU-like protein, putative antitoxin zf-Di19 PF05605.10 001195469.1_23523001_3 - 0.064 13.4 22.3 7 6.9 2.0 5.5 5 1 0 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding Kazal_1 PF00050.19 001195469.1_23523001_3 - 6.1 6.8 11.2 3.2 7.7 0.1 4.2 4 0 0 4 4 4 0 Kazal-type serine protease inhibitor domain PALP PF00291.23 001198643.1_23523001_3 - 5.9e-72 242.4 2.1 8.1e-72 242.0 2.1 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peripla_BP_6 PF13458.4 001198643.1_23523001_3 - 0.00014 21.5 2.1 0.078 12.5 0.0 2.5 2 1 1 3 3 3 2 Periplasmic binding protein AIRC PF00731.18 001198643.1_23523001_3 - 0.0013 18.2 2.4 0.26 10.7 0.5 2.5 2 0 0 2 2 2 2 AIR carboxylase SIS_2 PF13580.4 001198643.1_23523001_3 - 0.052 13.4 0.6 0.11 12.3 0.0 1.9 2 0 0 2 2 2 0 SIS domain IFRD PF05004.11 001198643.1_23523001_3 - 0.18 10.7 0.0 0.26 10.2 0.0 1.2 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) Sec8_exocyst PF04048.12 001199320.1_23529001_3 - 6e-18 65.0 1.4 6e-18 65.0 1.4 2.4 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.7 001199320.1_23529001_3 - 0.003 16.7 5.8 0.003 16.7 5.8 2.3 3 0 0 3 3 3 1 Vacuolar-sorting protein 54, of GARP complex PEP-utilisers_N PF05524.11 001199320.1_23529001_3 - 0.044 13.8 0.8 0.27 11.3 0.0 2.7 3 0 0 3 3 3 0 PEP-utilising enzyme, N-terminal T3SS_needle_E PF08988.8 001199320.1_23529001_3 - 0.15 12.1 2.0 0.68 10.0 0.3 2.9 2 1 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle COG5 PF10392.7 001199320.1_23529001_3 - 1.6 8.7 12.4 0.11 12.5 3.8 3.4 3 1 1 4 4 4 0 Golgi transport complex subunit 5 DUF4211 PF13926.4 001199414.1_23529001_2 - 2.1e-22 79.6 1.3 5.6e-22 78.2 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4211) Homeobox PF00046.27 001167686.1_23523001_2 - 2.2e-22 78.5 8.4 3.7e-22 77.8 8.4 1.4 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 001167686.1_23523001_2 - 2e-07 30.5 1.3 4.4e-07 29.4 1.3 1.6 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 001167686.1_23523001_2 - 0.013 15.2 0.4 0.013 15.2 0.4 1.9 2 0 0 2 2 2 0 Homeobox KN domain Homeobox PF00046.27 001167684.1_23523001_2 - 2.8e-22 78.1 8.4 4.5e-22 77.5 8.4 1.3 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 001167684.1_23523001_2 - 2.6e-07 30.1 1.3 5.2e-07 29.2 1.3 1.6 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 001167684.1_23523001_2 - 0.016 15.0 0.4 0.016 15.0 0.4 1.8 2 0 0 2 2 2 0 Homeobox KN domain SNARE PF05739.17 001167684.1_23523001_3 - 3.4 7.6 4.8 7.2 6.6 4.8 1.5 1 0 0 1 1 1 0 SNARE domain RRM_1 PF00076.20 001030843.2_23525001_2 - 1.2e-30 104.9 0.0 8e-15 54.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 001030843.2_23525001_2 - 3.2e-06 27.0 0.1 0.0017 18.2 0.0 2.3 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.4 001030843.2_23525001_2 - 0.006 16.4 0.0 0.4 10.5 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.4 001030843.2_23525001_2 - 0.015 14.8 0.0 5.8 6.4 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001030843.2_23525001_2 - 0.064 13.0 0.0 9.9 6.0 0.0 2.3 2 0 0 2 2 2 0 Occluded RNA-recognition motif Hormone_recep PF00104.28 001159345.1_23529001_2 - 4e-29 101.6 6.5 6.2e-29 100.9 6.5 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001159345.1_23529001_2 - 4e-28 97.5 13.0 8.5e-28 96.5 13.0 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) TPR_1 PF00515.26 001031502.2_23529001_1 - 1e-38 129.4 28.2 2.4e-06 27.0 0.0 9.0 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.15 001031502.2_23529001_1 - 1.8e-33 111.8 22.6 2.8e-05 23.8 1.6 9.7 9 0 0 9 9 9 7 Tetratricopeptide repeat DnaJ PF00226.29 001031502.2_23529001_1 - 7.1e-24 83.6 2.3 1.9e-23 82.2 2.3 1.8 1 0 0 1 1 1 1 DnaJ domain TPR_8 PF13181.4 001031502.2_23529001_1 - 5.5e-17 60.4 19.2 0.012 15.7 0.3 8.2 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_19 PF14559.4 001031502.2_23529001_1 - 3.4e-14 53.0 12.6 0.061 13.7 0.3 6.3 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.4 001031502.2_23529001_1 - 5.4e-13 48.2 8.9 0.00018 21.5 0.1 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.4 001031502.2_23529001_1 - 7.5e-13 48.4 16.8 8.6e-05 22.6 1.0 5.9 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.4 001031502.2_23529001_1 - 2.4e-12 47.2 2.5 0.0019 18.7 0.0 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.4 001031502.2_23529001_1 - 2.6e-10 39.7 31.2 4e-06 26.3 4.7 7.1 5 1 2 7 7 7 3 TPR repeat TPR_14 PF13428.4 001031502.2_23529001_1 - 9.8e-08 32.1 5.7 0.51 11.2 0.0 7.6 5 2 3 8 8 8 1 Tetratricopeptide repeat TPR_9 PF13371.4 001031502.2_23529001_1 - 9.3e-07 28.8 5.1 0.77 9.8 0.2 5.4 3 2 2 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.5 001031502.2_23529001_1 - 2.5e-05 24.3 23.6 0.007 16.4 0.4 5.2 3 2 3 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.4 001031502.2_23529001_1 - 0.00012 21.7 11.0 0.81 9.7 0.4 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.4 001031502.2_23529001_1 - 0.00069 19.3 9.4 2.5 8.0 0.4 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.4 001031502.2_23529001_1 - 0.0014 19.0 17.0 0.86 10.2 0.7 6.2 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_4 PF07721.12 001031502.2_23529001_1 - 0.043 14.3 0.1 7.9 7.3 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.10 001031502.2_23529001_1 - 1.1 9.2 6.9 1.9 8.5 4.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat RPN7 PF10602.7 001031502.2_23529001_1 - 3.4 7.1 12.0 1.3 8.5 4.4 3.0 2 1 1 3 3 3 0 26S proteasome subunit RPN7 MIT PF04212.16 001031502.2_23529001_1 - 5.9 6.9 20.5 1.2 9.2 0.8 4.7 3 2 1 4 4 4 0 MIT (microtubule interacting and transport) domain Parathyroid PF01279.15 205338.2_23523001_1 - 2.8e-37 127.5 0.5 5.1e-37 126.6 0.5 1.4 1 0 0 1 1 1 1 Parathyroid hormone family RRP14 PF15459.4 205338.2_23523001_1 - 6.4 7.3 10.9 11 6.5 10.9 1.3 1 0 0 1 1 1 0 60S ribosome biogenesis protein Rrp14 Ets PF00178.20 001199273.1_23529001_2 - 1.3e-29 102.3 1.5 3.4e-29 101.0 1.5 1.8 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 001199273.1_23529001_2 - 4.5e-26 90.5 0.0 7.9e-26 89.7 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Pkinase PF00069.23 001199411.1_23529001_2 - 4.2e-48 163.9 0.0 6.9e-48 163.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001199411.1_23529001_2 - 2.6e-23 82.5 0.0 4e-23 81.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001199411.1_23529001_2 - 1.5e-05 24.3 0.0 2.7e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001199411.1_23529001_2 - 0.017 14.9 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family CDK2AP PF09806.7 001039264.2_23523001_2 - 6.9e-19 68.7 0.0 9e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase 2-associated protein Rad60-SLD PF11976.6 001080717.2_23523001_2 - 8.1e-25 86.3 0.1 1.2e-24 85.8 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.21 001080717.2_23523001_2 - 6.8e-11 41.6 0.1 1e-10 41.1 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family Vps51 PF08700.9 001030707.2_23526001_1 - 1.8e-15 56.7 0.2 1.6e-14 53.6 0.0 2.5 2 0 0 2 2 2 1 Vps51/Vps67 DUF3510 PF12022.6 001030707.2_23526001_1 - 0.0046 17.2 0.0 0.11 12.7 0.0 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3510) COG5 PF10392.7 001030707.2_23526001_1 - 0.025 14.6 1.8 2.1 8.4 0.0 3.8 4 0 0 4 4 4 0 Golgi transport complex subunit 5 AAA_24 PF13479.4 001030707.2_23526001_1 - 0.14 11.7 0.4 0.57 9.7 0.1 2.1 3 0 0 3 3 3 0 AAA domain Treacle PF03546.12 001012785.2_23529001_1 - 1.2e-08 34.2 56.5 2.7e-06 26.4 30.4 7.3 1 1 5 7 7 7 5 Treacher Collins syndrome protein Treacle CD24 PF14984.4 001012785.2_23529001_3 - 0.38 10.9 3.2 1.2 9.3 3.2 1.9 1 0 0 1 1 1 0 CD24 protein LNS2 PF08235.11 001006386.3_23526001_3 - 1.7e-103 344.8 0.0 4e-103 343.6 0.0 1.6 2 0 0 2 2 2 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.12 001006386.3_23526001_3 - 2e-45 152.8 0.1 3.7e-45 152.0 0.1 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.3 001006386.3_23526001_3 - 1.1e-35 121.7 0.1 3.7e-35 120.1 0.1 1.9 2 0 0 2 2 2 1 Lipin/Ned1/Smp2 multi-domain protein middle domain WRNPLPNID PF15017.4 001006386.3_23526001_3 - 0.00025 21.7 0.5 0.00025 21.7 0.5 2.4 2 0 0 2 2 2 1 Putative WW-binding domain and destruction box 7tm_1 PF00001.19 001080886.1_23523001_1 - 8.6e-35 120.1 30.7 1.5e-34 119.4 30.7 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001080886.1_23523001_1 - 0.00021 20.6 36.5 0.021 14.0 36.5 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw PDR_CDR PF06422.10 001080886.1_23523001_1 - 1 9.2 11.0 4.3 7.2 2.4 3.2 2 1 1 3 3 3 0 CDR ABC transporter DUF4736 PF15883.3 001080886.1_23523001_1 - 1.3 8.6 5.2 0.92 9.1 1.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4736) 7tm_4 PF13853.4 001080886.1_23523001_1 - 1.6 8.3 27.9 2.6 7.6 27.9 1.3 1 1 0 1 1 1 0 Olfactory receptor Rhomboid PF01694.20 001080886.1_23523001_1 - 2.6 7.9 16.1 0.46 10.3 2.1 3.0 1 1 1 2 2 2 0 Rhomboid family 7TM_GPCR_Srx PF10328.7 001080886.1_23523001_1 - 3.7 6.6 39.8 0.041 13.1 25.3 2.1 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx V-set PF07686.15 198346.1_16124001_1 - 1e-27 96.3 2.5 1.2e-13 51.0 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 198346.1_16124001_1 - 2.4e-14 53.6 4.1 8e-07 29.4 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 198346.1_16124001_1 - 5.5e-12 45.5 1.4 4.8e-06 26.4 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 198346.1_16124001_1 - 2.4e-09 37.1 4.7 0.0009 19.2 0.9 2.6 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 198346.1_16124001_1 - 3e-05 24.1 9.9 0.04 14.1 0.4 3.6 2 2 0 2 2 2 2 Immunoglobulin domain TAS2R PF05296.11 001105135.1_16123001_1 - 1.1e-08 34.5 21.2 1.9e-08 33.7 21.2 1.5 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_4 PF13853.4 001128563.1_16123001_1 - 3.5e-50 171.2 24.7 4.2e-50 170.9 24.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001128563.1_16123001_1 - 1.9e-15 56.7 27.2 6.1e-15 55.0 27.2 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001128563.1_16123001_1 - 3.7e-08 32.9 24.6 4.6e-08 32.6 24.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.7 001128563.1_16123001_1 - 1.2e-05 24.9 13.1 1.2e-05 24.9 13.1 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srx PF10328.7 001128563.1_16123001_1 - 0.0069 15.6 19.7 0.012 14.8 19.7 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx EF1G PF00647.17 001089534.1_16123001_1 - 3.2e-49 165.3 6.1 3.9e-49 165.0 3.4 2.3 2 0 0 2 2 2 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.18 001089534.1_16123001_1 - 9.6e-19 67.4 0.2 9.8e-18 64.2 0.0 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001089534.1_16123001_1 - 5.3e-12 45.7 1.9 5.6e-12 45.6 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 001089534.1_16123001_1 - 1.3e-08 34.6 0.1 3.4e-08 33.2 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001089534.1_16123001_1 - 2.6e-06 27.6 0.0 6.5e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 001089534.1_16123001_1 - 1.5e-05 25.0 0.0 6.6e-05 22.9 0.0 2.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.4 001089534.1_16123001_1 - 0.00081 19.6 0.0 0.0019 18.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.2 001089534.1_16123001_1 - 0.055 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain V-set PF07686.15 001170943.1_16124001_1 - 1e-15 57.7 0.0 7.2e-08 32.4 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 001170943.1_16124001_1 - 5.2e-11 42.9 0.0 0.00027 21.3 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001170943.1_16124001_1 - 6.5e-08 32.4 0.1 0.0055 16.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Invasin_D3 PF09134.8 001170943.1_16124001_1 - 0.003 17.1 0.1 2.8 7.6 0.0 2.4 2 0 0 2 2 2 2 Invasin, domain 3 Adeno_E3_CR1 PF02440.13 001170943.1_16124001_1 - 0.024 14.3 0.1 6.6 6.4 0.0 2.8 2 1 0 2 2 2 0 Adenovirus E3 region protein CR1 MLANA PF14991.4 001170943.1_16124001_1 - 0.028 14.6 0.1 0.05 13.8 0.1 1.4 1 0 0 1 1 1 0 Protein melan-A C1-set PF07654.13 001017788.1_16123001_1 - 1.8e-21 76.3 0.3 3.5e-21 75.4 0.3 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_II_beta PF00969.17 001017788.1_16123001_1 - 8.3e-21 73.8 0.7 1.5e-20 72.9 0.7 1.4 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain Ig_3 PF13927.4 001017788.1_16123001_1 - 0.0011 19.4 0.1 0.003 18.0 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Gal_Lectin PF02140.16 001109841.1_16122001_1 - 2.2e-25 88.7 5.1 2.2e-25 88.7 5.1 1.5 2 0 0 2 2 2 1 Galactose binding lectin domain Reticulon PF02453.15 001020784.1_16124001_1 - 3.7e-46 156.8 4.5 3.7e-46 156.8 4.5 1.6 2 0 0 2 2 2 1 Reticulon Ribosomal_S7 PF00177.19 001045433.1_16122001_2 - 1.1e-36 125.6 1.6 1.5e-36 125.1 1.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Epimerase PF01370.19 001077284.1_16124001_1 - 3e-53 180.6 0.0 4.1e-53 180.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 001077284.1_16124001_1 - 2e-10 40.4 0.0 5.1e-10 39.1 0.0 1.5 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.15 001077284.1_16124001_1 - 7.5e-07 28.4 0.0 2.9e-06 26.4 0.0 1.8 2 0 0 2 2 2 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.13 001077284.1_16124001_1 - 0.00014 21.0 0.3 0.0018 17.3 0.0 2.3 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein Ig_3 PF13927.4 001099446.1_16126001_3 - 7.6e-05 23.1 6.8 8e-05 23.0 0.2 2.9 3 0 0 3 3 3 1 Immunoglobulin domain ig PF00047.23 001099446.1_16126001_3 - 0.0001 22.3 3.2 0.0019 18.2 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin domain EpoR_lig-bind PF09067.8 001099446.1_16126001_3 - 0.00012 22.1 0.0 0.00042 20.3 0.0 1.9 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 001099446.1_16126001_3 - 0.00022 21.4 1.0 0.01 16.0 0.1 2.5 2 0 0 2 2 2 1 Fibronectin type III domain Rax2 PF12768.5 001099446.1_16126001_3 - 0.067 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity IL8 PF00048.18 001115097.1_16121001_3 - 6.3e-18 64.6 2.4 6.3e-18 64.6 2.4 1.3 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.18 001115101.1_16121001_1 - 6.7e-06 26.0 1.1 6.7e-06 26.0 1.1 1.8 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like Alpha_adaptinC2 PF02883.18 001076650.1_16124001_2 - 6.5e-26 90.7 0.7 1e-25 90.1 0.7 1.3 1 0 0 1 1 1 1 Adaptin C-terminal domain Adaptin_N PF01602.18 001076650.1_16124001_2 - 8.6e-07 27.7 0.0 1.2e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region DUF11 PF01345.16 001076650.1_16124001_2 - 1.2 9.4 6.8 0.23 11.6 2.4 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF11 Exo84_C PF16528.3 001110475.1_16125001_2 - 1.2e-56 191.6 5.4 2.2e-56 190.8 0.1 2.8 2 1 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.9 001110475.1_16125001_2 - 1.9e-19 69.4 6.0 8.4e-19 67.3 6.0 2.3 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.9 001110475.1_16125001_2 - 1.3e-05 25.2 1.8 7e-05 22.8 1.8 2.3 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 PH PF00169.27 001110475.1_16125001_2 - 0.00069 20.0 0.1 0.0021 18.4 0.1 1.9 1 0 0 1 1 1 1 PH domain Dor1 PF04124.10 001110475.1_16125001_2 - 0.0023 16.6 14.6 0.04 12.5 1.9 3.8 3 1 0 3 3 3 2 Dor1-like family DUF4446 PF14584.4 001110475.1_16125001_2 - 0.036 13.9 0.4 0.036 13.9 0.4 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) COG5 PF10392.7 001110475.1_16125001_2 - 0.41 10.7 9.3 0.061 13.4 4.5 2.2 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Trypsin_2 PF13365.4 001105142.1_16123001_3 - 2.5e-14 54.3 0.1 3.6e-14 53.7 0.1 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.4 001105142.1_16123001_3 - 1.4e-10 41.2 0.0 3.2e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.22 001105142.1_16123001_3 - 3.2e-08 33.7 0.2 6e-08 32.8 0.2 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Trypsin PF00089.24 001105142.1_16123001_3 - 5.8e-08 32.7 0.0 8.6e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Trypsin Tricorn_PDZ PF14685.4 001105142.1_16123001_3 - 0.012 15.5 0.1 0.026 14.4 0.1 1.5 1 0 0 1 1 1 0 Tricorn protease PDZ domain Peptidase_S46 PF10459.7 001105142.1_16123001_3 - 0.022 13.3 0.4 0.029 12.9 0.4 1.1 1 0 0 1 1 1 0 Peptidase S46 DUF31 PF01732.14 001105142.1_16123001_3 - 0.22 10.9 0.5 0.29 10.5 0.5 1.1 1 0 0 1 1 1 0 Putative peptidase (DUF31) SR-25 PF10500.7 001100173.1_16122001_1 - 0.037 13.5 9.5 0.047 13.2 9.5 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Histone PF00125.22 001100173.1_16122001_3 - 2.1e-54 183.3 2.4 2.1e-54 183.3 2.4 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.4 001100173.1_16122001_3 - 5.2e-05 23.2 0.1 0.00011 22.1 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.4 001100173.1_16122001_3 - 0.00069 19.8 0.0 0.0011 19.1 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.21 001100173.1_16122001_3 - 0.015 15.4 0.1 0.038 14.1 0.1 1.7 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Orexin PF02072.13 001277472.1_23524001_2 - 0.34 10.7 3.7 0.76 9.6 3.7 1.6 1 0 0 1 1 1 0 Prepro-orexin BTB PF00651.29 001079729.1_23525001_1 - 1.5e-19 70.1 0.1 2.5e-19 69.4 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 001079729.1_23525001_1 - 3.6e-06 27.0 10.4 0.00015 21.9 1.6 3.5 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001079729.1_23525001_1 - 7.3e-06 26.2 15.8 0.037 14.7 2.4 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.24 001079729.1_23525001_1 - 0.0033 17.7 16.7 0.09 13.1 0.3 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 001079729.1_23525001_1 - 0.016 15.0 12.8 1.9 8.4 0.3 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger HNH PF01844.21 001079729.1_23525001_1 - 0.37 10.9 3.0 5.8 7.0 0.5 2.7 2 0 0 2 2 2 0 HNH endonuclease Zn_Tnp_IS1595 PF12760.5 001079729.1_23525001_1 - 0.76 9.7 4.0 1.6 8.6 4.0 1.6 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-C2H2_11 PF16622.3 001079729.1_23525001_1 - 0.87 9.3 7.8 5.6 6.7 2.9 2.6 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.5 001079729.1_23525001_1 - 5 7.4 7.3 3.1e+02 1.6 1.6 2.7 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) FYVE PF01363.19 001079729.1_23525001_1 - 7.7 6.6 7.3 1.3e+02 2.6 7.4 2.6 1 1 0 1 1 1 0 FYVE zinc finger zf-C2H2_jaz PF12171.6 001079729.1_23525001_1 - 7.9 6.8 13.1 3.1 8.1 0.3 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding PRY PF13765.4 001020475.1_16124001_1 - 3.2e-24 84.1 0.0 7.8e-24 82.9 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 001020475.1_16124001_1 - 6.4e-18 64.9 0.3 1.3e-17 63.9 0.3 1.5 1 0 0 1 1 1 1 SPRY domain zf-RING_UBOX PF13445.4 001020475.1_16124001_1 - 5.3e-11 42.2 10.2 5.3e-11 42.2 10.2 3.2 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001020475.1_16124001_1 - 3.9e-09 36.1 17.7 3.9e-09 36.1 17.7 2.9 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001020475.1_16124001_1 - 4.3e-09 36.2 9.8 4.3e-09 36.2 9.8 4.4 3 1 0 3 3 2 1 B-box zinc finger zf-C3HC4_2 PF13923.4 001020475.1_16124001_1 - 2.9e-08 33.3 16.2 2.9e-08 33.3 16.2 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001020475.1_16124001_1 - 8.9e-08 31.7 13.0 8.9e-08 31.7 13.0 3.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001020475.1_16124001_1 - 1.2e-07 31.6 17.9 1.2e-07 31.6 17.9 3.4 4 0 0 4 4 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 001020475.1_16124001_1 - 4.4e-07 29.9 16.4 4.4e-07 29.9 16.4 3.4 3 0 0 3 3 2 1 Ring finger domain U-box PF04564.13 001020475.1_16124001_1 - 8.5e-07 28.9 0.0 1.9e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 U-box domain Prok-RING_4 PF14447.4 001020475.1_16124001_1 - 0.00014 21.5 14.0 0.00014 21.5 14.0 3.2 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 001020475.1_16124001_1 - 0.00077 19.2 16.4 0.00077 19.2 16.4 3.2 3 0 0 3 3 2 1 zinc-RING finger domain zf-Nse PF11789.6 001020475.1_16124001_1 - 0.0081 15.8 9.4 0.046 13.4 9.9 2.1 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit DUF1342 PF07072.9 001020475.1_16124001_1 - 0.043 13.4 8.0 0.11 12.1 8.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1342) Mtc PF03820.15 001020475.1_16124001_1 - 0.12 11.3 0.2 0.33 9.8 0.0 1.7 2 0 0 2 2 2 0 Tricarboxylate carrier zf-RING_11 PF17123.3 001020475.1_16124001_1 - 0.35 10.5 9.4 0.1 12.2 5.3 2.4 1 1 0 1 1 1 0 RING-like zinc finger zf-C2H2 PF00096.24 001020475.1_16124001_1 - 4.9 7.7 10.2 1.7 9.1 1.4 3.6 3 0 0 3 3 2 0 Zinc finger, C2H2 type Exonuc_VII_L PF02601.13 001020475.1_16124001_1 - 6.5 6.1 8.9 11 5.3 8.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1289 PF06945.11 001020475.1_16124001_3 - 2 8.1 6.8 0.39 10.4 1.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) V-set PF07686.15 001037577.1_16124001_2 - 1.8e-10 40.8 8.2 0.0016 18.5 0.0 4.1 2 2 1 3 3 3 3 Immunoglobulin V-set domain Ig_3 PF13927.4 001037577.1_16124001_2 - 3.8e-07 30.5 2.5 0.00035 21.0 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain Lep_receptor_Ig PF06328.9 001037577.1_16124001_2 - 0.0011 18.8 0.6 0.45 10.5 0.0 3.5 3 0 0 3 3 3 1 Ig-like C2-type domain Ig_2 PF13895.4 001037577.1_16124001_2 - 0.0016 18.6 6.1 0.064 13.5 0.1 3.1 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 001037577.1_16124001_2 - 0.0091 15.9 1.6 2.8 8.0 0.1 3.8 2 2 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.23 001037577.1_16124001_2 - 0.019 15.0 3.2 0.3 11.1 0.1 3.5 3 1 0 3 3 3 0 Immunoglobulin domain TMEM154 PF15102.4 001037577.1_16124001_2 - 0.036 13.8 0.1 0.071 12.9 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF912 PF06024.10 001037577.1_16124001_2 - 0.049 13.8 0.2 0.12 12.5 0.2 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Lectin_C PF00059.19 001114908.1_16123001_1 - 2.8e-07 31.1 0.0 4.9e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain Cornifin PF02389.13 001114908.1_16123001_2 - 0.026 14.6 15.2 0.46 10.6 8.2 3.1 1 1 2 3 3 3 0 Cornifin (SPRR) family UDPGT PF00201.16 001040345.1_16125001_1 - 1.5e-156 522.0 0.2 1.8e-156 521.7 0.2 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase UPF0560 PF10577.7 001040345.1_16125001_1 - 0.011 14.1 0.4 0.017 13.6 0.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Glyco_tran_28_C PF04101.14 001040345.1_16125001_1 - 0.015 15.2 0.0 0.025 14.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain 7tm_1 PF00001.19 001113167.1_23523001_3 - 1.1e-62 211.6 27.0 1.4e-62 211.2 27.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001113167.1_23523001_3 - 7.6e-14 51.6 23.8 9.4e-14 51.3 23.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001113167.1_23523001_3 - 7.8e-09 35.2 20.5 8.1e-09 35.1 14.4 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 001113167.1_23523001_3 - 5.3e-06 25.8 22.4 1.8e-05 24.1 22.4 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001113167.1_23523001_3 - 0.00049 19.8 22.8 0.00094 18.9 22.8 1.5 1 1 0 1 1 1 1 Olfactory receptor Piezo_RRas_bdg PF12166.6 001113167.1_23523001_3 - 0.0083 15.3 1.2 0.2 10.7 0.2 2.3 2 0 0 2 2 2 1 Piezo non-specific cation channel, R-Ras-binding domain T2SSM PF04612.10 001113167.1_23523001_3 - 0.033 14.1 0.2 0.094 12.6 0.2 1.8 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M COX7C PF02935.14 001113167.1_23523001_3 - 0.11 12.7 5.7 0.73 10.0 0.3 2.8 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIIc DUF3995 PF13160.4 001113167.1_23523001_3 - 5.9 7.1 10.6 10 6.4 3.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3995) IIGP PF05049.11 001076611.1_16125001_3 - 9.5e-101 337.4 2.4 1.3e-100 337.0 0.9 1.9 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) zf-B_box PF00643.22 001076611.1_16125001_3 - 6.2e-10 38.9 1.9 6.2e-10 38.9 1.9 3.1 2 1 0 2 2 1 1 B-box zinc finger zf-RING_UBOX PF13445.4 001076611.1_16125001_3 - 2.4e-09 36.9 5.8 2.4e-09 36.9 5.8 2.6 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 001076611.1_16125001_3 - 1.1e-08 34.7 9.1 1.1e-08 34.7 9.1 2.9 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001076611.1_16125001_3 - 3.1e-08 33.2 10.9 3.1e-08 33.2 10.9 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001076611.1_16125001_3 - 1.2e-07 31.6 10.5 1.2e-07 31.6 10.5 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001076611.1_16125001_3 - 1.3e-07 31.2 11.1 1.3e-07 31.2 11.1 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001076611.1_16125001_3 - 2.7e-06 27.1 9.6 2.7e-06 27.1 9.6 3.1 3 0 0 3 3 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 001076611.1_16125001_3 - 3.1e-06 27.2 10.9 3.1e-06 27.2 10.9 2.7 2 0 0 2 2 2 1 Ring finger domain U-box PF04564.13 001076611.1_16125001_3 - 4.7e-06 26.5 0.0 1.2e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 U-box domain MMR_HSR1 PF01926.21 001076611.1_16125001_3 - 4.8e-06 26.5 0.0 1.3e-05 25.1 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Prok-RING_4 PF14447.4 001076611.1_16125001_3 - 9.8e-06 25.2 10.5 9.8e-06 25.2 10.5 2.9 3 1 1 4 4 3 1 Prokaryotic RING finger family 4 ABC_tran PF00005.25 001076611.1_16125001_3 - 0.00023 21.6 0.0 0.00079 19.8 0.0 1.8 2 0 0 2 2 1 1 ABC transporter T2SSE PF00437.18 001076611.1_16125001_3 - 0.00083 18.4 0.1 0.012 14.6 0.1 2.1 2 0 0 2 2 2 1 Type II/IV secretion system protein zf-Nse PF11789.6 001076611.1_16125001_3 - 0.0012 18.5 5.2 0.0031 17.2 5.2 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Dynamin_N PF00350.21 001076611.1_16125001_3 - 0.0027 17.6 3.3 0.61 10.0 0.3 3.2 2 1 2 4 4 4 2 Dynamin family AAA_29 PF13555.4 001076611.1_16125001_3 - 0.0028 17.2 0.0 0.0058 16.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain FeoB_N PF02421.16 001076611.1_16125001_3 - 0.0057 16.1 0.0 0.012 15.1 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B zf-RING_4 PF14570.4 001076611.1_16125001_3 - 0.0077 15.8 2.9 0.0077 15.8 2.9 2.9 3 0 0 3 3 3 1 RING/Ubox like zinc-binding domain ArgK PF03308.14 001076611.1_16125001_3 - 0.018 13.9 0.8 0.27 10.1 0.1 2.2 1 1 1 2 2 2 0 ArgK protein DUF258 PF03193.14 001076611.1_16125001_3 - 0.019 14.7 0.1 0.076 12.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 CoaE PF01121.18 001076611.1_16125001_3 - 0.033 13.7 1.2 0.6 9.6 0.1 2.3 2 0 0 2 2 2 0 Dephospho-CoA kinase DUF87 PF01935.15 001076611.1_16125001_3 - 0.039 13.8 0.4 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF87 zf-C3HC4_5 PF17121.3 001076611.1_16125001_3 - 0.044 13.5 6.2 0.18 11.6 6.2 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FtsK_SpoIIIE PF01580.16 001076611.1_16125001_3 - 0.062 12.5 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_assoc_C PF09821.7 001076611.1_16125001_3 - 0.12 12.8 0.1 0.32 11.4 0.1 1.7 1 0 0 1 1 1 0 C-terminal AAA-associated domain AAA_22 PF13401.4 001076611.1_16125001_3 - 0.13 12.4 0.0 0.41 10.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain zf-RING-like PF08746.9 001076611.1_16125001_3 - 0.61 10.3 9.4 2.1 8.6 9.4 2.0 1 0 0 1 1 1 0 RING-like domain AAA_23 PF13476.4 001076611.1_16125001_3 - 2.3 8.6 12.6 0.058 13.8 2.9 2.6 1 1 1 2 2 2 0 AAA domain zf-H2C2_2 PF13465.4 001135989.1_16124001_3 - 3.1e-62 204.3 75.0 2.8e-09 36.9 0.7 11.8 11 1 0 11 11 11 8 Zinc-finger double domain zf-C2H2 PF00096.24 001135989.1_16124001_3 - 4.3e-51 168.5 87.8 2.4e-06 27.5 1.0 12.0 12 0 0 12 12 11 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001135989.1_16124001_3 - 6.8e-41 135.3 78.5 2.3e-05 24.7 3.0 12.1 12 1 0 12 12 11 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001135989.1_16124001_3 - 7.4e-22 76.7 71.1 0.0017 18.1 2.0 11.6 11 1 0 11 11 11 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001135989.1_16124001_3 - 5.5e-12 45.5 43.2 0.019 15.1 0.3 9.8 9 1 0 9 9 9 6 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 001135989.1_16124001_3 - 1e-07 31.5 54.3 0.02 14.5 0.3 10.3 11 0 0 11 11 11 5 zinc-finger C2H2-type zf-LYAR PF08790.9 001135989.1_16124001_3 - 9e-07 28.6 56.3 0.3 10.9 0.2 10.8 11 0 0 11 11 11 4 LYAR-type C2HC zinc finger C1_1 PF00130.20 001135989.1_16124001_3 - 5.6e-06 26.0 39.1 0.2 11.4 0.6 7.4 2 2 7 9 9 9 5 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn-ribbon_8 PF09723.8 001135989.1_16124001_3 - 6.4e-06 26.0 48.4 0.17 11.9 3.3 8.2 4 2 7 11 11 10 6 Zinc ribbon domain zf-met PF12874.5 001135989.1_16124001_3 - 2.5e-05 24.4 69.7 0.15 12.4 3.6 10.2 10 0 0 10 10 10 4 Zinc-finger of C2H2 type HypA PF01155.17 001135989.1_16124001_3 - 6.2e-05 22.9 34.6 0.26 11.2 0.8 6.0 1 1 5 6 6 6 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-H2C2_5 PF13909.4 001135989.1_16124001_3 - 6.6e-05 22.4 93.3 0.063 12.9 0.3 13.0 12 1 0 12 12 11 6 C2H2-type zinc-finger domain ADK_lid PF05191.12 001135989.1_16124001_3 - 0.0027 17.5 28.3 2.5 8.1 0.3 7.1 4 2 4 8 8 8 2 Adenylate kinase, active site lid zinc_ribbon_15 PF17032.3 001135989.1_16124001_3 - 0.0047 17.5 47.7 0.46 11.1 2.4 6.3 2 2 5 7 7 6 4 zinc-ribbon family zf-C2HE PF16278.3 001135989.1_16124001_3 - 0.005 17.1 70.5 0.035 14.4 0.1 9.9 4 3 5 9 9 9 3 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.5 001135989.1_16124001_3 - 0.011 15.9 60.5 2.5 8.4 1.8 9.2 1 1 7 9 9 9 0 C2H2 type zinc-finger (2 copies) CpXC PF14353.4 001135989.1_16124001_3 - 0.012 15.5 41.9 0.33 10.9 1.7 8.6 2 2 6 8 8 8 0 CpXC protein Cementoin PF10511.7 001135989.1_16124001_3 - 0.06 13.2 0.2 49 4.0 0.0 3.5 4 0 0 4 4 4 0 Trappin protein transglutaminase binding domain zf-RING_7 PF02591.13 001135989.1_16124001_3 - 0.073 13.1 27.2 16 5.7 0.1 8.9 9 0 0 9 9 9 0 C4-type zinc ribbon domain GAGA PF09237.9 001135989.1_16124001_3 - 0.091 12.4 10.6 7 6.4 0.1 5.1 2 1 4 6 6 6 0 GAGA factor zf-trcl PF13451.4 001135989.1_16124001_3 - 0.13 12.0 42.4 6.9 6.5 0.0 9.1 9 0 0 9 9 9 0 Probable zinc-ribbon domain XPA_N PF01286.16 001135989.1_16124001_3 - 0.19 11.7 47.2 3.7 7.5 0.1 9.7 10 0 0 10 10 10 0 XPA protein N-terminal zf-AN1 PF01428.14 001135989.1_16124001_3 - 0.55 10.3 51.9 13 5.9 0.2 9.6 6 2 2 9 9 9 0 AN1-like Zinc finger LIM PF00412.20 001135989.1_16124001_3 - 1.1 9.5 51.2 0.076 13.1 3.6 7.5 1 1 7 8 8 8 0 LIM domain DUF3268 PF11672.6 001135989.1_16124001_3 - 4.3 7.6 31.9 6.8 6.9 3.7 5.2 2 1 1 5 5 5 0 zinc-finger-containing domain Peptidase_C14 PF00656.20 001083862.1_16123001_1 - 9.7e-47 159.9 0.1 1.4e-46 159.4 0.1 1.1 1 0 0 1 1 1 1 Caspase domain CARD PF00619.19 001083862.1_16123001_1 - 1.3e-06 28.2 2.2 3.1e-06 27.0 1.7 1.9 2 0 0 2 2 2 1 Caspase recruitment domain Lectin_C PF00059.19 001128708.1_16122001_1 - 3.8e-21 75.7 7.8 7.5e-11 42.6 1.3 2.1 2 0 0 2 2 2 2 Lectin C-type domain zf-HC5HC2H PF13771.4 001128708.1_16122001_1 - 1.4 9.1 4.6 0.25 11.5 0.7 1.8 2 0 0 2 2 2 0 PHD-like zinc-binding domain V-set PF07686.15 001115106.1_16123001_1 - 1.2e-13 51.0 0.0 2.4e-12 46.8 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001115106.1_16123001_1 - 6.7e-08 32.9 0.1 0.0035 17.8 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001115106.1_16123001_1 - 1.1e-06 28.5 0.0 0.0032 17.5 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001115106.1_16123001_1 - 2e-05 24.4 0.1 0.014 15.3 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin I-set domain C2-set_2 PF08205.10 001115106.1_16123001_1 - 7e-05 22.7 0.0 0.00014 21.7 0.0 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 001115106.1_16123001_1 - 0.00013 22.2 0.0 1.4 9.2 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin domain Vpu PF00558.17 001115106.1_16123001_1 - 0.086 12.5 1.3 0.17 11.6 1.3 1.5 1 0 0 1 1 1 0 Vpu protein PRY PF13765.4 001115106.1_16123001_2 - 0.0039 16.6 0.0 0.0072 15.8 0.0 1.5 1 0 0 1 1 1 1 SPRY-associated domain Transferrin PF00405.15 001114466.1_16125001_1 - 2.3e-143 477.2 2.6 3.5e-81 272.8 0.0 2.1 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 001114466.1_16125001_1 - 1.7e-08 34.2 0.0 0.00026 20.5 0.0 2.6 2 1 0 2 2 2 2 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.18 001114466.1_16125001_1 - 0.12 11.6 0.0 12 5.1 0.1 2.9 3 0 0 3 3 3 0 Bacterial extracellular solute-binding proteins, family 3 VKOR PF07884.12 206807.1_23522001_1 - 4.5e-25 88.1 7.3 5.8e-25 87.7 7.3 1.1 1 0 0 1 1 1 1 Vitamin K epoxide reductase family Forkhead PF00250.16 205006.1_23524001_1 - 1e-39 134.6 0.1 1.6e-39 134.0 0.1 1.3 1 0 0 1 1 1 1 Forkhead domain 7tm_1 PF00001.19 001080894.1_23523001_1 - 1.1e-48 165.7 26.2 2.2e-48 164.7 26.2 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001080894.1_23523001_1 - 0.011 15.1 24.8 0.014 14.7 24.8 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx ADH_N PF08240.10 205092.1_23523001_2 - 9.8e-28 96.1 0.1 2e-27 95.1 0.1 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.24 205092.1_23523001_2 - 7.6e-26 90.4 0.2 1.7e-25 89.3 0.2 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.12 205092.1_23523001_2 - 0.0081 15.6 0.1 0.013 14.9 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.16 205092.1_23523001_2 - 0.062 13.4 0.4 0.12 12.5 0.0 1.6 2 0 0 2 2 2 0 TrkA-N domain 2-Hacid_dh_C PF02826.17 205092.1_23523001_2 - 0.072 12.3 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain zf-C4 PF00105.16 001279486.1_37523001_1 - 2.8e-32 110.8 12.3 5.8e-32 109.8 12.3 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001279486.1_37523001_1 - 3.6e-31 108.2 3.6 5.2e-31 107.7 3.6 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor 7tm_4 PF13853.4 001256345.1_16122001_1 - 8.8e-39 133.8 28.9 1.1e-38 133.4 28.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001256345.1_16122001_1 - 3.1e-12 46.2 30.0 2e-11 43.5 30.0 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001256345.1_16122001_1 - 4.6e-07 29.3 29.3 1.7e-06 27.5 29.3 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001256345.1_16122001_1 - 0.0012 18.1 20.9 0.0012 18.1 20.9 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx TGFb_propeptide PF00688.16 212975.1_16124001_1 - 1.4e-43 149.3 0.1 1.9e-43 148.9 0.1 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 212975.1_16124001_1 - 3e-28 98.6 2.4 8.1e-28 97.3 2.4 1.8 1 0 0 1 1 1 1 Transforming growth factor beta like domain zf-HC5HC2H_2 PF13832.4 001199482.1_23529001_3 - 6.4e-37 125.9 4.5 6.4e-37 125.9 4.5 2.6 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.7 001199482.1_23529001_3 - 1.3e-34 119.7 1.7 1.3e-34 119.7 1.7 1.8 2 0 0 2 2 2 1 Enhancer of polycomb-like zf-HC5HC2H PF13771.4 001199482.1_23529001_3 - 2.9e-26 91.4 2.9 2.9e-26 91.4 2.9 3.7 3 0 0 3 3 3 1 PHD-like zinc-binding domain Bromodomain PF00439.23 001199482.1_23529001_3 - 3.4e-25 87.8 0.4 7.2e-25 86.7 0.4 1.6 1 0 0 1 1 1 1 Bromodomain PWWP PF00855.15 001199482.1_23529001_3 - 1e-13 51.4 0.0 4.1e-13 49.5 0.0 2.1 1 0 0 1 1 1 1 PWWP domain PHD_2 PF13831.4 001199482.1_23529001_3 - 2.8e-13 49.0 4.4 2.8e-13 49.0 4.4 2.8 2 0 0 2 2 2 1 PHD-finger PHD PF00628.27 001199482.1_23529001_3 - 4.7e-06 26.3 13.5 4.7e-06 26.3 13.5 3.2 3 0 0 3 3 3 2 PHD-finger AAA_23 PF13476.4 001199482.1_23529001_3 - 0.0034 17.8 5.1 0.022 15.1 1.0 2.6 2 0 0 2 2 2 1 AAA domain DNA_topoisoIV PF00521.18 001199482.1_23529001_3 - 0.3 9.8 4.8 0.53 9.0 4.8 1.3 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A ABC_membrane_2 PF06472.13 001199395.1_23525001_1 - 5.4e-106 353.9 4.4 7.1e-106 353.5 4.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.25 001199395.1_23525001_1 - 4.5e-18 66.0 0.0 8.9e-18 65.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 001199395.1_23525001_1 - 0.00011 22.1 0.0 0.00018 21.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.4 001199395.1_23525001_1 - 0.001 19.5 0.5 0.0035 17.7 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.4 001199395.1_23525001_1 - 0.0046 16.5 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.17 001199395.1_23525001_1 - 0.033 13.5 0.1 0.2 11.0 0.1 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Rad17 PF03215.13 001199395.1_23525001_1 - 0.047 12.5 0.0 0.076 11.8 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein ARID PF01388.19 001199395.1_23525001_1 - 0.05 14.1 0.1 0.17 12.4 0.1 1.9 1 0 0 1 1 1 0 ARID/BRIGHT DNA binding domain Adeno_IVa2 PF02456.13 001199395.1_23525001_1 - 0.069 11.8 0.1 0.12 11.0 0.1 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein Cyto_heme_lyase PF01265.15 001199395.1_23525001_1 - 0.094 12.1 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase AAA_16 PF13191.4 001199395.1_23525001_1 - 0.1 12.8 0.0 0.28 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Collagen PF01391.16 001162390.1_23529001_3 - 3.2e-184 596.8 672.9 1.9e-09 37.0 29.0 27.4 10 9 15 26 26 26 26 Collagen triple helix repeat (20 copies) C4 PF01413.17 001162390.1_23529001_3 - 3.2e-81 268.8 1.3 3.3e-44 149.7 0.1 2.2 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Mod_r PF07200.11 001199569.1_23525001_2 - 1.4e-26 93.2 20.7 2.1e-26 92.6 20.7 1.2 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein DUF737 PF05300.9 001199569.1_23525001_2 - 0.82 9.9 11.3 0.062 13.5 6.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF737) Exonuc_VII_L PF02601.13 001199569.1_23525001_2 - 2.8 7.3 5.0 3.8 6.8 5.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit CHCH PF06747.11 001277655.1_23522001_2 - 2.3e-08 33.8 1.6 2.3e-08 33.8 1.6 2.5 2 1 1 3 3 3 1 CHCH domain Cmc1 PF08583.8 001277655.1_23522001_2 - 0.24 11.3 8.4 0.23 11.4 1.2 2.5 1 1 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.3 001277655.1_23522001_2 - 0.54 10.2 10.9 0.54 10.2 1.9 2.8 2 1 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, DSPc PF00782.18 001277882.1_23522001_2 - 2.5e-18 66.1 0.0 3e-18 65.8 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 001277882.1_23522001_2 - 0.00019 20.9 0.1 0.00054 19.5 0.1 1.7 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.11 001277882.1_23522001_2 - 0.0047 16.4 0.0 0.0056 16.1 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPn PF14671.4 001277882.1_23522001_2 - 0.0075 16.6 0.0 0.011 16.0 0.0 1.2 1 0 0 1 1 1 1 Dual specificity protein phosphatase, N-terminal half PTPlike_phytase PF14566.4 001277882.1_23522001_2 - 0.07 13.1 0.0 0.12 12.4 0.0 1.4 2 0 0 2 2 2 0 Inositol hexakisphosphate 7tm_1 PF00001.19 001279660.1_37524001_1 - 6e-75 251.8 8.3 8.4e-75 251.3 8.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001279660.1_37524001_1 - 1.9e-07 30.5 6.8 1.9e-07 30.5 6.8 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001279660.1_37524001_1 - 2.3e-05 24.1 1.5 2.3e-05 24.1 1.5 2.4 2 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srbc PF10316.7 001279660.1_37524001_1 - 0.00011 21.7 9.0 0.00021 20.8 5.6 2.3 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc p450 PF00067.20 001279575.1_37525001_1 - 3.9e-108 362.0 0.0 5e-108 361.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 7tm_1 PF00001.19 001279657.1_37524001_1 - 1.7e-74 250.3 0.3 2.4e-74 249.8 0.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001279657.1_37524001_1 - 2.4e-06 27.3 5.0 2.4e-06 27.3 5.0 1.9 2 1 1 3 3 3 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001279657.1_37524001_1 - 3.2e-05 23.3 14.3 0.00015 21.2 8.2 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx LAP1C PF05609.10 001279657.1_37524001_1 - 1.5 7.7 7.6 2.3 7.1 7.6 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) TraL PF07178.9 001279657.1_37524001_2 - 0.47 10.8 2.8 14 6.1 0.4 2.4 2 0 0 2 2 2 0 TraL protein Spot_14 PF07084.10 001130789.1_16121001_1 - 9.4e-29 100.4 0.3 2.1e-28 99.3 0.3 1.5 1 1 0 1 1 1 1 Thyroid hormone-inducible hepatic protein Spot 14 DUF3697 PF12478.6 001277104.1_23527001_3 - 2.5e-16 59.3 0.8 6.2e-16 58.1 0.8 1.7 1 0 0 1 1 1 1 Ubiquitin-associated protein 2 UBA_4 PF14555.4 001277104.1_23527001_3 - 0.00011 21.8 0.0 0.00022 20.8 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain DUF1296 PF06972.9 001277104.1_23527001_3 - 0.0097 15.9 0.1 0.022 14.7 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1296) UBA PF00627.29 001277104.1_23527001_3 - 0.022 14.5 0.1 0.044 13.6 0.1 1.4 1 0 0 1 1 1 0 UBA/TS-N domain CUE PF02845.14 001277104.1_23527001_3 - 0.053 13.1 0.1 0.15 11.6 0.1 1.8 1 0 0 1 1 1 0 CUE domain E1-E2_ATPase PF00122.18 001271974.1_23529001_1 - 4.8e-64 215.6 1.3 4.8e-64 215.6 1.3 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 001271974.1_23529001_1 - 9.3e-46 155.7 2.4 2.8e-45 154.1 2.4 1.9 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 001271974.1_23529001_1 - 6.9e-21 74.0 0.3 1.3e-20 73.2 0.3 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 001271974.1_23529001_1 - 1.2e-17 64.8 0.0 2.7e-16 60.3 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 001271974.1_23529001_1 - 6.6e-17 60.8 1.2 2.4e-16 59.0 0.2 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 001271974.1_23529001_1 - 1.2e-05 25.0 0.6 2.6e-05 23.9 0.6 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 001271974.1_23529001_1 - 0.0046 17.2 0.1 0.017 15.4 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase RhoGAP PF00620.25 001277745.1_23527001_3 - 3.7e-37 127.4 0.1 4.6e-36 123.8 0.0 2.6 2 0 0 2 2 2 1 RhoGAP domain Drc1-Sld2 PF11719.6 001277745.1_23527001_3 - 0.0042 16.6 10.0 0.0042 16.6 10.0 3.6 2 1 2 4 4 4 2 DNA replication and checkpoint protein PilJ PF13675.4 001277745.1_23527001_3 - 0.16 11.9 4.6 1.7 8.6 1.1 2.8 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Pkinase PF00069.23 001287193.1_23529001_3 - 2.6e-41 141.6 0.0 8.8e-41 139.9 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001287193.1_23529001_3 - 3.8e-40 137.7 0.0 2.7e-39 134.9 0.0 2.4 2 0 0 2 2 2 1 Protein tyrosine kinase Roc PF08477.11 001287193.1_23529001_3 - 6.6e-31 106.9 0.0 1.9e-30 105.5 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase COR PF16095.3 001287193.1_23529001_3 - 1.8e-26 93.0 0.5 1.8e-25 89.8 0.3 2.3 2 0 0 2 2 2 1 C-terminal of Roc, COR, domain LRR_8 PF13855.4 001287193.1_23529001_3 - 1.5e-24 85.3 39.8 8.8e-08 31.7 1.3 6.9 4 2 2 6 6 6 5 Leucine rich repeat LRR_4 PF12799.5 001287193.1_23529001_3 - 7.9e-23 79.9 47.6 2.8e-07 30.6 0.5 8.4 3 2 5 9 9 9 7 Leucine Rich repeats (2 copies) Ras PF00071.20 001287193.1_23529001_3 - 3.4e-15 55.9 0.0 8e-15 54.7 0.0 1.6 1 0 0 1 1 1 1 Ras family Arf PF00025.19 001287193.1_23529001_3 - 3.2e-07 29.8 0.9 1.5e-06 27.6 0.1 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family Ank_2 PF12796.5 001287193.1_23529001_3 - 7.2e-06 26.4 1.2 8.1e-05 23.0 0.3 2.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) LRR_9 PF14580.4 001287193.1_23529001_3 - 8.3e-05 22.0 12.9 0.0078 15.6 1.3 3.5 1 1 3 4 4 4 2 Leucine-rich repeat Gtr1_RagA PF04670.10 001287193.1_23529001_3 - 0.00035 19.9 0.0 0.00078 18.7 0.0 1.6 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region NB-ARC PF00931.20 001287193.1_23529001_3 - 0.0077 15.2 0.1 0.018 14.0 0.1 1.6 1 0 0 1 1 1 1 NB-ARC domain T2SSE PF00437.18 001287193.1_23529001_3 - 0.018 14.0 0.0 0.039 12.9 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein TrwB_AAD_bind PF10412.7 001287193.1_23529001_3 - 0.02 13.7 0.2 0.073 11.8 0.0 1.9 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain NACHT PF05729.10 001287193.1_23529001_3 - 0.025 14.4 0.2 0.088 12.6 0.2 1.9 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.25 001287193.1_23529001_3 - 0.028 14.8 0.1 0.086 13.2 0.1 1.8 1 0 0 1 1 1 0 ABC transporter PduV-EutP PF10662.7 001287193.1_23529001_3 - 0.031 13.9 0.4 0.068 12.8 0.4 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.18 001287193.1_23529001_3 - 0.042 12.9 0.5 0.092 11.8 0.0 1.7 2 0 0 2 2 2 0 G-protein alpha subunit TFCD_C PF12612.6 001287193.1_23529001_3 - 0.042 13.6 3.6 2 8.1 0.2 4.2 4 0 0 4 4 4 0 Tubulin folding cofactor D C terminal AAA_16 PF13191.4 001287193.1_23529001_3 - 0.048 13.9 0.0 0.17 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain cobW PF02492.17 001287193.1_23529001_3 - 0.049 13.1 0.4 0.098 12.1 0.4 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.16 001287193.1_23529001_3 - 0.054 12.7 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Arm PF00514.21 001287193.1_23529001_3 - 0.057 13.3 4.7 0.62 10.1 0.0 4.4 5 0 0 5 5 4 0 Armadillo/beta-catenin-like repeat AAA_22 PF13401.4 001287193.1_23529001_3 - 0.061 13.5 0.2 0.26 11.4 0.2 2.2 1 1 0 1 1 1 0 AAA domain Kdo PF06293.12 001287193.1_23529001_3 - 0.064 12.5 0.1 0.15 11.3 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ank_4 PF13637.4 001287193.1_23529001_3 - 0.088 13.3 0.0 0.59 10.7 0.0 2.6 1 1 1 2 2 2 0 Ankyrin repeats (many copies) ATP_bind_1 PF03029.15 001287193.1_23529001_3 - 0.1 12.2 0.3 3.2 7.3 0.2 2.5 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.21 001287193.1_23529001_3 - 0.1 12.6 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.4 001287193.1_23529001_3 - 0.11 12.1 0.0 0.29 10.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MobB PF03205.12 001287193.1_23529001_3 - 0.13 12.1 0.2 0.34 10.7 0.2 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B LRR_6 PF13516.4 001287193.1_23529001_3 - 0.16 11.9 37.1 5.7 7.1 0.1 10.3 10 0 0 10 10 10 0 Leucine Rich repeat AAA_33 PF13671.4 001287193.1_23529001_3 - 0.17 11.9 0.1 0.46 10.5 0.1 1.7 1 0 0 1 1 1 0 AAA domain Syncollin PF15138.4 015620.1_16122120_1 - 8.5e-55 183.6 2.5 8.5e-55 183.6 2.5 1.6 2 0 0 2 2 2 1 Syncollin Granulin PF00396.16 001279700.1_37522001_2 - 9.4e-23 80.2 48.2 1.7e-13 50.5 18.2 4.9 3 2 2 5 5 5 4 Granulin FA_desaturase PF00487.22 001279623.1_37524001_2 - 1.8e-30 106.5 22.0 1.8e-30 106.5 22.0 1.9 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.26 001279623.1_37524001_2 - 5e-22 77.7 0.0 9.4e-22 76.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain p450 PF00067.20 001279576.1_37525001_1 - 9.9e-102 340.9 0.0 1.1e-101 340.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 3Beta_HSD PF01073.17 001279673.1_37523001_3 - 1e-92 310.0 0.0 1.3e-92 309.7 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 001279673.1_37523001_3 - 6.2e-22 78.1 0.0 8.6e-22 77.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 001279673.1_37523001_3 - 2.1e-15 56.4 0.5 2.2e-14 53.1 0.5 2.0 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.3 001279673.1_37523001_3 - 7.2e-15 55.0 0.0 1.2e-14 54.4 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.13 001279673.1_37523001_3 - 1.7e-11 43.7 0.0 4.4e-11 42.3 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.4 001279673.1_37523001_3 - 3.5e-10 40.0 0.0 4.8e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 001279673.1_37523001_3 - 1.2e-07 31.1 0.0 1.8e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.16 001279673.1_37523001_3 - 1.8e-06 28.1 0.1 0.00068 19.8 0.0 2.2 2 0 0 2 2 2 2 Saccharopine dehydrogenase NADP binding domain KR PF08659.8 001279673.1_37523001_3 - 1.1e-05 25.4 0.0 8.7e-05 22.4 0.0 2.1 1 1 0 1 1 1 1 KR domain NmrA PF05368.11 001279673.1_37523001_3 - 6.6e-05 22.4 0.0 9.7e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.23 001279673.1_37523001_3 - 0.055 12.8 0.0 0.1 11.9 0.0 1.4 1 1 0 1 1 1 0 short chain dehydrogenase Globin PF00042.20 001279683.1_37522001_1 - 1.8e-21 76.6 0.0 2.7e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 Globin Lipase PF00151.17 001279753.1_37525001_1 - 1.6e-111 372.8 0.0 2.4e-111 372.2 0.0 1.2 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 001279753.1_37525001_1 - 6.8e-16 58.8 0.7 1.4e-15 57.7 0.7 1.6 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.5 001279753.1_37525001_1 - 2e-06 28.5 1.1 3e-06 27.9 1.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 001279753.1_37525001_1 - 7.9e-06 25.6 0.1 1.3e-05 24.9 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold zf-piccolo PF05715.11 001279753.1_37525001_1 - 0.028 14.5 1.8 0.11 12.5 1.8 2.0 1 0 0 1 1 1 0 Piccolo Zn-finger Leptin PF02024.13 001301050.1_37521001_1 - 9.1e-06 25.4 0.0 1.4e-05 24.7 0.0 1.4 1 1 0 1 1 1 1 Leptin 7tm_1 PF00001.19 001279595.1_37526001_1 - 9.9e-30 103.5 19.4 1.6e-29 102.9 19.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.4 001279595.1_37526001_1 - 2.7e-17 62.1 2.7 0.00015 21.3 0.2 4.6 2 2 2 5 5 5 4 Leucine rich repeat LRR_5 PF13306.4 001279595.1_37526001_1 - 9.2e-12 44.9 2.7 8.9e-06 25.6 1.7 2.5 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRRNT PF01462.16 001279595.1_37526001_1 - 0.035 13.6 3.0 0.14 11.7 3.0 2.1 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain LRR_4 PF12799.5 001279595.1_37526001_1 - 0.052 13.8 3.6 3.5 8.0 0.0 4.2 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) BNR_2 PF13088.4 001293137.1_37523001_1 - 2.2e-31 109.1 0.0 3e-31 108.6 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.4 001293137.1_37523001_1 - 3.6e-11 42.8 0.0 4.5e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain 7tm_1 PF00001.19 001279760.1_37524001_1 - 9.8e-48 162.6 10.9 1.3e-47 162.2 10.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001279760.1_37524001_1 - 3.9e-09 36.1 8.9 5.3e-09 35.7 8.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TIP39 PF14980.4 001279492.1_37522001_2 - 5.7e-33 112.4 1.4 1.5e-32 111.0 0.7 2.0 2 0 0 2 2 2 1 TIP39 peptide DM PF00751.16 001279767.1_37524001_1 - 1.3e-21 76.0 12.9 2.7e-21 75.0 12.9 1.6 1 0 0 1 1 1 1 DM DNA binding domain GHBP PF12772.5 001279601.1_37526001_2 - 1.1e-87 294.3 4.9 1.6e-87 293.7 4.9 1.2 1 0 0 1 1 1 1 Growth hormone receptor binding EpoR_lig-bind PF09067.8 001279601.1_37526001_2 - 1.7e-07 31.3 3.8 1.7e-07 31.3 3.8 1.9 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 001279601.1_37526001_2 - 0.00011 22.3 0.1 0.00046 20.3 0.1 2.0 1 0 0 1 1 1 1 Fibronectin type III domain IL6Ra-bind PF09240.8 001279601.1_37526001_2 - 0.018 15.3 2.4 0.075 13.3 1.8 2.2 2 0 0 2 2 2 0 Interleukin-6 receptor alpha chain, binding LRR_8 PF13855.4 001279604.1_37524001_2 - 2.4e-33 113.5 10.1 1e-13 50.7 2.5 4.5 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 001279604.1_37524001_2 - 3e-16 59.0 14.5 0.0067 16.7 0.0 5.9 2 2 5 7 7 7 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001279604.1_37524001_2 - 8.5e-10 38.3 5.1 0.00043 19.7 2.5 3.3 2 1 1 3 3 3 2 Leucine-rich repeat LRR_5 PF13306.4 001279604.1_37524001_2 - 2.2e-08 34.0 1.0 0.0026 17.6 0.1 2.9 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRRNT PF01462.16 001279604.1_37524001_2 - 9.7e-08 31.4 13.0 1.3e-07 30.9 6.6 3.3 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 001279604.1_37524001_2 - 0.11 13.0 12.8 10 6.9 0.3 7.4 7 2 0 7 7 7 0 Leucine Rich Repeat LRR_6 PF13516.4 001279604.1_37524001_2 - 0.58 10.2 8.4 40 4.5 0.0 5.1 6 0 0 6 6 6 0 Leucine Rich repeat CENP-B_dimeris PF09026.8 001279604.1_37524001_2 - 8.3 6.7 14.1 19 5.6 14.1 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain GST_N_3 PF13417.4 001279634.1_37522001_1 - 7.5e-12 45.3 0.0 1.4e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 001279634.1_37522001_1 - 4.3e-10 39.7 0.0 6.8e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 001279634.1_37522001_1 - 1.9e-09 37.5 0.0 3.6e-09 36.6 0.0 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 001279634.1_37522001_1 - 6.6e-09 35.9 0.0 1.2e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001279634.1_37522001_1 - 4.1e-06 26.8 0.0 7e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.2 001279634.1_37522001_1 - 0.00041 20.9 0.0 0.00066 20.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.4 001279634.1_37522001_1 - 0.0032 17.2 0.0 0.006 16.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Trypsin PF00089.24 001279442.1_37522001_1 - 3.9e-64 216.3 2.4 4.6e-64 216.1 2.4 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001279442.1_37522001_1 - 2.9e-07 31.3 0.0 4.5e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001279442.1_37522001_1 - 7.5e-07 29.4 0.4 1.3e-06 28.6 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Biopterin_H PF00351.19 001279521.1_37524001_1 - 2e-177 589.0 0.0 2.6e-177 588.7 0.0 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.23 001279521.1_37524001_1 - 1.9e-06 27.4 0.0 3.8e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 ACT domain Insulin PF00049.16 001279636.1_37524001_2 - 0.00043 21.1 3.7 0.25 12.2 1.3 2.6 1 1 1 2 2 2 2 Insulin/IGF/Relaxin family TNF PF00229.16 001279533.1_37523001_1 - 1.2e-27 96.2 0.1 1.7e-27 95.8 0.1 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family DUF4381 PF14316.4 001279533.1_37523001_1 - 0.013 15.6 0.1 0.021 14.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) cNMPbd_u2 PF16643.3 001279533.1_37523001_3 - 0.12 12.7 2.2 0.19 12.0 2.2 1.2 1 0 0 1 1 1 0 Unstructured region on cNMP-binding protein FBA PF04300.11 001279692.1_37522001_1 - 6.4e-48 162.8 0.0 8.8e-48 162.4 0.0 1.2 1 0 0 1 1 1 1 F-box associated region Peptidase_S68 PF10461.7 001279692.1_37522001_1 - 0.098 12.7 0.0 0.64 10.1 0.0 2.1 2 0 0 2 2 2 0 Peptidase S68 HLH PF00010.24 001279574.1_37522001_1 - 2.4e-16 59.3 0.2 4.2e-16 58.5 0.2 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.12 001279574.1_37522001_1 - 0.051 11.8 1.3 0.054 11.7 1.3 1.0 1 0 0 1 1 1 0 CDC45-like protein FRG2 PF15315.4 001279574.1_37522001_1 - 0.055 13.5 5.6 0.076 13.1 5.6 1.1 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 Pkinase_Tyr PF07714.15 001309405.1_37525001_2 - 3.1e-94 315.0 0.0 4e-94 314.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001309405.1_37525001_2 - 4.5e-48 163.8 0.0 6.5e-48 163.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001309405.1_37525001_2 - 5.3e-25 87.2 0.1 1.1e-24 86.2 0.1 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001309405.1_37525001_2 - 7.7e-16 57.3 0.1 1.7e-15 56.2 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001309405.1_37525001_2 - 1.1e-09 37.7 0.0 2.4e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 001309405.1_37525001_2 - 2.1e-09 37.0 0.1 4.1e-09 36.0 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain Kdo PF06293.12 001309405.1_37525001_2 - 0.042 13.1 0.0 0.072 12.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GRIP PF01465.18 001309405.1_37525001_2 - 0.12 12.2 0.1 0.45 10.3 0.0 2.0 2 0 0 2 2 2 0 GRIP domain ELO PF01151.16 001279460.1_37523001_3 - 1.7e-63 214.3 32.0 2.2e-63 214.0 32.0 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family C1-set PF07654.13 001279562.1_37523001_3 - 6.9e-25 87.2 0.1 1.4e-24 86.2 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_II_beta PF00969.17 001279562.1_37523001_3 - 4.6e-15 55.4 0.6 8.3e-15 54.6 0.6 1.4 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C2-set_2 PF08205.10 001279562.1_37523001_3 - 7.6e-05 22.6 0.1 0.00014 21.7 0.1 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 001279562.1_37523001_3 - 0.00046 20.6 0.0 0.0009 19.7 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain adh_short PF00106.23 001279648.1_37523001_2 - 2.1e-29 102.3 0.2 4.9e-23 81.5 0.5 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.4 001279648.1_37523001_2 - 1.3e-20 73.8 0.0 7e-15 55.1 0.1 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001279648.1_37523001_2 - 5.4e-06 26.3 0.0 8e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 KR domain HATPase_c PF02518.24 001279648.1_37523001_2 - 0.03 14.8 0.2 0.2 12.1 0.0 2.1 2 1 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_L32e PF01655.16 001279655.1_37521001_3 - 2.9e-56 188.3 2.5 3.5e-56 188.1 2.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 LMSTEN PF07988.10 001279655.1_37521001_3 - 0.037 13.3 0.1 0.08 12.3 0.1 1.5 1 0 0 1 1 1 0 LMSTEN motif Basic PF01586.14 001279720.1_37523001_3 - 2.7e-30 105.3 0.9 7.7e-30 103.8 0.9 1.8 1 0 0 1 1 1 1 Myogenic Basic domain Myf5 PF12232.6 001279720.1_37523001_3 - 3.7e-26 91.5 8.0 3.7e-26 91.5 8.0 2.7 2 0 0 2 2 2 1 Myogenic determination factor 5 HLH PF00010.24 001279720.1_37523001_3 - 8.9e-15 54.3 2.3 1.6e-14 53.5 2.3 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF3446 PF11928.6 001279720.1_37523001_3 - 0.013 15.7 2.4 0.013 15.7 2.4 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF3446) DUF4692 PF15763.3 001279720.1_37523001_3 - 7 7.0 7.1 14 6.0 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4692) Gastrin PF00918.15 001279730.1_37522001_1 - 6e-44 149.9 0.0 7.8e-44 149.5 0.0 1.1 1 0 0 1 1 1 1 Gastrin/cholecystokinin family Folate_rec PF03024.12 001279741.1_37525001_1 - 8.7e-52 175.3 16.0 1.2e-51 174.9 16.0 1.2 1 0 0 1 1 1 1 Folate receptor family Agouti PF05039.10 001279579.1_37521001_1 - 2.8e-13 50.2 15.7 4.3e-13 49.6 15.7 1.3 1 1 0 1 1 1 1 Agouti protein FGF PF00167.16 001279618.1_37525001_1 - 9e-45 151.7 0.2 1.4e-44 151.1 0.2 1.3 1 0 0 1 1 1 1 Fibroblast growth factor BNR_2 PF13088.4 001293135.1_37523001_1 - 2.5e-43 148.3 0.0 3.1e-43 147.9 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.4 001293135.1_37523001_1 - 3.4e-09 36.3 0.0 5e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.18 001293135.1_37523001_1 - 0.00027 20.3 4.0 0.2 11.6 0.2 2.9 2 0 0 2 2 2 2 BNR/Asp-box repeat BNR_4 PF15892.3 001293135.1_37523001_1 - 0.027 13.7 0.0 0.044 13.0 0.0 1.3 1 0 0 1 1 1 0 BNR repeat-containing family member p450 PF00067.20 001282895.1_37524001_1 - 7.8e-62 209.4 0.0 1e-61 209.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Enamelin PF15362.4 001291401.1_02229001_1 - 6.1e-265 881.8 82.4 1.5e-264 880.5 82.4 1.6 1 1 0 1 1 1 1 Enamelin MHC_II_alpha PF00993.18 001099426.1_16125001_3 - 4.4e-22 77.4 0.1 7.1e-22 76.8 0.1 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set PF07654.13 001099426.1_16125001_3 - 7.4e-22 77.5 0.1 1.2e-21 76.9 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain C1-set_C PF16196.3 001099426.1_16125001_3 - 4.3e-07 29.1 0.8 2.9e-06 26.4 0.7 2.2 2 0 0 2 2 2 1 C1-set C-terminal domain Ig_3 PF13927.4 001099426.1_16125001_3 - 4.2e-05 23.9 0.0 9.3e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 001099426.1_16125001_3 - 0.00062 19.7 0.0 0.001 18.9 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.14 001099426.1_16125001_3 - 0.0012 18.8 0.1 0.0017 18.2 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain C1q PF00386.19 001045007.1_16123001_3 - 3.1e-63 211.5 1.7 1.9e-31 108.8 0.4 2.1 2 0 0 2 2 2 2 C1q domain zf-C3HC4_4 PF15227.4 001005315.1_16122001_1 - 1.8e-16 59.9 14.7 7.8e-16 57.8 8.0 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 001005315.1_16122001_1 - 1.4e-11 44.1 9.7 1.5e-11 44.0 6.1 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001005315.1_16122001_1 - 1.4e-11 43.9 15.0 4.6e-10 39.1 7.5 2.9 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001005315.1_16122001_1 - 2.2e-11 43.3 7.6 2.2e-11 43.3 7.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001005315.1_16122001_1 - 7.4e-10 38.4 4.4 7.4e-10 38.4 4.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001005315.1_16122001_1 - 5.7e-09 36.0 16.6 1.4e-08 34.7 7.6 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 001005315.1_16122001_1 - 3.8e-05 23.4 6.6 3.8e-05 23.4 6.6 2.8 2 1 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.4 001005315.1_16122001_1 - 0.00045 19.9 6.0 0.00045 19.9 6.0 2.9 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 U-box PF04564.13 001005315.1_16122001_1 - 0.00064 19.7 0.0 0.0016 18.4 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-ANAPC11 PF12861.5 001005315.1_16122001_1 - 0.018 15.0 2.8 0.045 13.7 2.8 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.4 001005315.1_16122001_1 - 0.038 13.6 14.5 0.053 13.1 9.2 2.7 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.3 001005315.1_16122001_1 - 0.053 13.1 3.9 0.17 11.5 3.9 1.9 1 0 0 1 1 1 0 RING-like zinc finger zf-Nse PF11789.6 001005315.1_16122001_1 - 0.059 13.1 3.0 0.12 12.1 3.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Baculo_IE-1 PF05290.9 001005315.1_16122001_1 - 0.61 9.9 6.0 1.3 8.8 2.7 2.2 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) zf-RING_6 PF14835.4 001005315.1_16122001_1 - 0.69 9.7 6.8 0.16 11.7 2.1 2.1 2 0 0 2 2 2 0 zf-RING of BARD1-type protein XOO_2897-deam PF14440.4 001005315.1_16122001_1 - 1 9.4 0.0 1 9.4 0.0 3.4 3 1 1 4 4 4 0 Xanthomonas XOO_2897-like deaminase Zip PF02535.20 001005315.1_16122001_1 - 2.9 6.9 5.7 4.1 6.4 5.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter zf-C6H2 PF15801.3 001005315.1_16122001_1 - 6.9 6.9 17.9 0.16 12.1 1.9 3.8 2 1 1 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding zf-rbx1 PF12678.5 001005315.1_16122001_1 - 8.2 6.7 13.8 0.56 10.4 7.4 2.4 2 1 0 2 2 2 0 RING-H2 zinc finger domain Sprouty PF05210.11 001079736.1_23522001_1 - 8.3e-32 109.7 32.3 1.6e-31 108.8 32.3 1.5 1 0 0 1 1 1 1 Sprouty protein (Spry) TSP_1 PF00090.17 001277502.1_23522001_1 - 8.3e-09 35.4 5.5 8.3e-09 35.4 5.5 2.8 2 0 0 2 2 2 1 Thrombospondin type 1 domain Somatomedin_B PF01033.15 001277502.1_23522001_1 - 3.1e-05 24.1 22.6 3.1e-05 24.1 22.6 2.8 3 0 0 3 3 3 1 Somatomedin B domain EIN3 PF04873.11 001277502.1_23522001_3 - 3 7.0 4.1 4 6.5 4.1 1.1 1 0 0 1 1 1 0 Ethylene insensitive 3 zf-H2C2_2 PF13465.4 001045237.1_16124001_3 - 1.9e-67 220.7 107.3 8.3e-08 32.2 6.7 14.5 14 0 0 14 14 14 12 Zinc-finger double domain zf-C2H2 PF00096.24 001045237.1_16124001_3 - 2.6e-52 172.3 118.2 4e-05 23.7 0.9 13.4 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001045237.1_16124001_3 - 4.2e-38 126.6 109.7 0.00072 20.1 1.7 13.8 14 0 0 14 14 13 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001045237.1_16124001_3 - 5.3e-30 102.7 78.7 5.1e-07 29.4 0.2 12.5 12 0 0 12 12 12 10 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001045237.1_16124001_3 - 9.1e-09 34.8 70.9 0.024 14.3 0.2 12.7 13 0 0 13 13 13 7 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 001045237.1_16124001_3 - 7.4e-07 29.2 60.6 1.3 9.3 0.5 12.3 13 0 0 13 13 13 5 Zinc-finger double-stranded RNA-binding C1_1 PF00130.20 001045237.1_16124001_3 - 3.6e-06 26.6 61.3 0.36 10.6 1.6 10.5 3 2 6 9 9 9 6 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_15 PF17032.3 001045237.1_16124001_3 - 0.00024 21.7 52.9 0.31 11.7 1.2 7.2 2 1 5 9 9 9 7 zinc-ribbon family zf-RING_7 PF02591.13 001045237.1_16124001_3 - 0.00093 19.2 35.7 3.6 7.7 0.1 9.8 11 0 0 11 11 11 2 C4-type zinc ribbon domain HypA PF01155.17 001045237.1_16124001_3 - 0.0011 18.8 42.6 0.68 9.8 0.2 7.1 1 1 6 7 7 7 6 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ADK_lid PF05191.12 001045237.1_16124001_3 - 0.1 12.5 46.2 0.18 11.7 0.4 7.7 2 2 9 11 11 11 0 Adenylate kinase, active site lid zf-met PF12874.5 001045237.1_16124001_3 - 0.3 11.4 87.1 0.082 13.2 3.7 13.1 13 0 0 13 13 13 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 001045237.1_16124001_3 - 0.53 10.3 67.1 1.3 9.0 3.2 9.2 5 4 5 10 10 10 0 Zinc ribbon domain zf-LYAR PF08790.9 001045237.1_16124001_3 - 0.96 9.3 0.0 0.96 9.3 0.0 11.4 12 0 0 12 12 12 0 LYAR-type C2HC zinc finger Ig_3 PF13927.4 001083366.1_23522001_1 - 3.4e-22 78.7 1.2 2.3e-13 50.4 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001083366.1_23522001_1 - 7.2e-19 67.6 0.5 5e-09 36.1 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001083366.1_23522001_1 - 5.7e-16 58.5 4.0 1.7e-09 37.7 0.1 3.1 3 1 0 3 3 3 2 Immunoglobulin V-set domain I-set PF07679.14 001083366.1_23522001_1 - 3.6e-15 55.7 0.0 6.9e-09 35.5 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 001083366.1_23522001_1 - 8.7e-15 54.7 1.0 5.6e-08 32.9 0.1 2.5 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001083366.1_23522001_1 - 9.6e-05 22.3 0.8 0.0002 21.3 0.0 1.8 2 1 0 2 2 2 1 CD80-like C2-set immunoglobulin domain RnaseA PF00074.18 001163652.1_23521001_1 - 1.8e-34 118.7 0.1 2e-34 118.5 0.1 1.0 1 0 0 1 1 1 1 Pancreatic ribonuclease Syntaxin PF00804.23 205074.2_23522001_1 - 3.7e-64 216.0 18.0 3.7e-64 216.0 18.0 1.3 2 0 0 2 2 1 1 Syntaxin SNARE PF05739.17 205074.2_23522001_1 - 4.9e-22 77.6 3.5 7e-22 77.0 1.3 2.4 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.4 205074.2_23522001_1 - 5.3e-10 39.4 7.2 5.3e-10 39.4 7.2 2.5 1 1 1 2 2 2 1 Syntaxin-like protein AAA_13 PF13166.4 205074.2_23522001_1 - 6.6e-05 21.6 15.1 8.4e-05 21.3 15.1 1.1 1 0 0 1 1 1 1 AAA domain GNVR PF13807.4 205074.2_23522001_1 - 0.011 15.6 0.1 0.029 14.2 0.1 1.7 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase Lzipper-MIP1 PF14389.4 205074.2_23522001_1 - 0.016 15.3 0.5 0.016 15.3 0.5 2.6 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Acyl-CoA_dh_2 PF08028.9 205074.2_23522001_1 - 0.052 13.7 0.3 0.13 12.4 0.3 1.7 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain RE_NgoFVII PF09565.8 205074.2_23522001_1 - 0.075 12.2 8.6 0.11 11.6 8.1 1.6 1 1 0 1 1 1 0 NgoFVII restriction endonuclease DUF1910 PF08928.8 205074.2_23522001_1 - 0.091 12.6 12.3 0.83 9.5 1.2 3.4 1 1 3 4 4 4 0 Domain of unknown function (DUF1910) WXG100 PF06013.10 205074.2_23522001_1 - 0.11 12.7 5.1 4.5 7.4 0.3 4.0 4 0 0 4 4 4 0 Proteins of 100 residues with WXG MCM_N PF14551.4 205074.2_23522001_1 - 0.14 12.7 3.8 0.34 11.4 0.3 2.7 1 1 0 2 2 2 0 MCM N-terminal domain TolA_bind_tri PF16331.3 205074.2_23522001_1 - 0.17 11.8 4.2 0.39 10.7 0.0 3.4 4 2 0 4 4 3 0 TolA binding protein trimerisation MCPsignal PF00015.19 205074.2_23522001_1 - 0.18 11.4 10.6 1.6 8.3 1.2 2.3 1 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Baculo_PEP_C PF04513.10 205074.2_23522001_1 - 0.19 11.6 4.0 0.67 9.9 0.2 2.6 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus GlutR_dimer PF00745.18 205074.2_23522001_1 - 0.29 11.4 12.8 1.2 9.4 0.4 3.2 2 1 2 4 4 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain DUF948 PF06103.9 205074.2_23522001_1 - 0.45 10.7 7.9 3.1 8.0 0.9 3.9 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Sec34 PF04136.13 205074.2_23522001_1 - 0.78 9.5 12.3 0.24 11.1 0.4 3.2 1 1 1 3 3 3 0 Sec34-like family SIMPL PF04402.12 205074.2_23522001_1 - 1.1 9.5 8.6 3.4 7.9 8.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF541) Uso1_p115_C PF04871.11 205074.2_23522001_1 - 1.2 9.4 22.0 0.31 11.3 8.0 3.2 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Syntaxin-6_N PF09177.9 205074.2_23522001_1 - 1.8 9.0 15.0 0.14 12.6 4.1 3.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Med9 PF07544.11 205074.2_23522001_1 - 3.4 7.7 9.8 1 9.4 1.1 3.4 2 2 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Wtap PF17098.3 205074.2_23522001_1 - 4 7.2 14.9 0.4 10.5 1.0 3.5 3 1 0 3 3 3 0 WTAP/Mum2p family ETRAMP PF09716.8 205074.2_23522001_1 - 4.1 7.4 5.6 2.6 8.0 0.7 2.6 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) YtxH PF12732.5 205074.2_23522001_1 - 4.5 7.8 11.4 4 7.9 2.2 3.7 1 1 1 2 2 2 0 YtxH-like protein Herpes_UL25 PF01499.14 205074.2_23522001_1 - 5.5 5.2 9.3 0.96 7.7 3.5 2.0 1 1 0 2 2 2 0 Herpesvirus UL25 family Amino_oxidase PF01593.22 001199599.1_23523001_2 - 3.3e-08 33.1 0.0 4.6e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 001199599.1_23523001_2 - 1.3e-07 31.6 0.4 3e-07 30.5 0.4 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001199599.1_23523001_2 - 0.00021 20.9 2.2 0.024 14.2 2.0 2.7 1 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.12 001199599.1_23523001_2 - 0.013 14.6 0.3 0.077 12.1 0.3 2.0 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Atg14 PF10186.7 001199599.1_23523001_2 - 0.029 13.3 0.0 0.045 12.7 0.0 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Pyr_redox PF00070.25 001199599.1_23523001_2 - 0.036 14.5 0.1 1.2 9.6 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Filament PF00038.19 001293122.1_02224001_1 - 3.2e-94 315.9 30.7 3.7e-94 315.7 30.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001293122.1_02224001_1 - 7.1e-06 26.2 18.0 7.1e-06 26.2 18.0 2.3 2 1 0 2 2 1 1 Keratin type II head Spc7 PF08317.9 001293122.1_02224001_1 - 1.9e-05 23.6 22.7 0.0052 15.6 7.2 2.1 2 0 0 2 2 2 2 Spc7 kinetochore protein TPR_MLP1_2 PF07926.10 001293122.1_02224001_1 - 4.2e-05 23.5 20.5 0.005 16.8 4.2 2.6 2 0 0 2 2 2 2 TPR/MLP1/MLP2-like protein ATG16 PF08614.9 001293122.1_02224001_1 - 5.1e-05 23.4 22.4 0.00016 21.8 3.7 3.1 2 1 1 3 3 3 2 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.7 001293122.1_02224001_1 - 0.0011 18.4 20.7 0.03 13.7 7.4 2.3 2 0 0 2 2 2 2 Golgin subfamily A member 5 DivIC PF04977.13 001293122.1_02224001_1 - 0.0032 17.1 13.7 0.089 12.4 0.4 3.6 2 1 1 3 3 3 2 Septum formation initiator CENP-F_leu_zip PF10473.7 001293122.1_02224001_1 - 0.0045 16.9 27.5 0.097 12.6 8.8 3.2 2 2 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1192 PF06698.9 001293122.1_02224001_1 - 0.022 14.7 5.4 0.38 10.7 1.6 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) BRE1 PF08647.9 001293122.1_02224001_1 - 0.028 14.4 21.8 0.046 13.7 1.1 3.6 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase DUF4793 PF16041.3 001293122.1_02224001_1 - 0.034 14.2 0.5 0.24 11.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4793) COG2 PF06148.9 001293122.1_02224001_1 - 0.057 13.4 11.4 0.66 9.9 0.8 3.6 2 2 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Seryl_tRNA_N PF02403.20 001293122.1_02224001_1 - 0.1 12.7 15.6 1.3 9.2 3.6 2.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Baculo_PEP_C PF04513.10 001293122.1_02224001_1 - 0.12 12.3 0.1 1.7 8.5 0.0 2.6 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Syntaxin-6_N PF09177.9 001293122.1_02224001_1 - 0.2 12.1 9.8 1 9.8 1.3 2.9 2 1 0 2 2 2 0 Syntaxin 6, N-terminal IFT20 PF14931.4 001293122.1_02224001_1 - 0.24 11.5 10.8 4.7 7.3 4.6 2.7 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 DUF3450 PF11932.6 001293122.1_02224001_1 - 0.26 10.4 17.3 0.032 13.4 3.0 3.0 2 2 0 2 2 2 0 Protein of unknown function (DUF3450) DUF4407 PF14362.4 001293122.1_02224001_1 - 0.29 10.3 10.5 1.6 7.9 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DASH_Spc19 PF08287.9 001293122.1_02224001_1 - 0.31 10.8 16.3 0.045 13.6 3.6 2.3 2 0 0 2 2 2 0 Spc19 KxDL PF10241.7 001293122.1_02224001_1 - 0.33 11.1 3.3 0.18 12.0 0.3 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein APG6 PF04111.10 001293122.1_02224001_1 - 0.39 9.9 26.5 0.41 9.8 8.5 2.2 2 0 0 2 2 2 0 Autophagy protein Apg6 GIT_CC PF16559.3 001293122.1_02224001_1 - 0.51 10.3 10.3 20 5.2 0.4 4.3 4 0 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor Alanine_zipper PF11839.6 001293122.1_02224001_1 - 0.54 10.4 8.4 0.39 10.9 4.6 2.3 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein ADIP PF11559.6 001293122.1_02224001_1 - 0.99 9.3 15.9 0.62 10.0 5.3 2.6 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding MscS_porin PF12795.5 001293122.1_02224001_1 - 1.1 8.6 9.1 0.1 12.0 1.9 2.1 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain TMF_TATA_bd PF12325.6 001293122.1_02224001_1 - 1.4 9.0 19.2 4.6 7.4 3.9 2.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Bacillus_HBL PF05791.9 001293122.1_02224001_1 - 1.5 8.4 7.5 0.88 9.1 0.3 2.8 3 1 0 3 3 2 0 Bacillus haemolytic enterotoxin (HBL) Laminin_II PF06009.10 001293122.1_02224001_1 - 1.7 8.5 8.2 1.5 8.7 0.6 2.9 2 1 1 3 3 3 0 Laminin Domain II SOGA PF11365.6 001293122.1_02224001_1 - 2 9.5 11.3 8.6 7.4 0.1 3.0 3 0 0 3 3 2 0 Protein SOGA Tma16 PF11176.6 001293122.1_02224001_1 - 2.9 7.6 12.2 0.048 13.4 3.9 2.2 2 1 1 3 3 3 0 Translation machinery-associated protein 16 Jnk-SapK_ap_N PF09744.7 001293122.1_02224001_1 - 2.9 8.0 25.8 0.58 10.2 5.4 3.4 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 DUF342 PF03961.11 001293122.1_02224001_1 - 3.5 6.0 15.6 1.3 7.5 2.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Spc24 PF08286.9 001293122.1_02224001_1 - 3.6 7.7 13.0 1.4 9.1 1.6 3.1 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 JIP_LZII PF16471.3 001293122.1_02224001_1 - 5 7.2 14.1 6.3 6.9 0.9 4.3 4 0 0 4 4 4 0 JNK-interacting protein leucine zipper II DUF1664 PF07889.10 001293122.1_02224001_1 - 5.7 6.8 8.1 3.9 7.3 0.4 2.9 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) ZapB PF06005.10 001293122.1_02224001_1 - 6.1 7.2 25.5 5.1 7.5 3.9 4.2 3 1 0 3 3 3 0 Cell division protein ZapB DUF4140 PF13600.4 001293122.1_02224001_1 - 7.7 6.9 12.2 3 8.2 2.2 3.3 3 1 1 4 4 3 0 N-terminal domain of unknown function (DUF4140) DUF883 PF05957.11 001293122.1_02224001_1 - 8.2 6.9 11.9 7.6 7.1 3.5 3.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) ERM PF00769.17 001293122.1_02224001_1 - 8.8 5.9 27.8 2.1 8.0 8.2 2.4 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Defensin_beta PF00711.17 001293130.1_02221001_1 - 0.00045 20.1 8.8 0.00059 19.7 8.8 1.2 1 0 0 1 1 1 1 Beta defensin Defensin_beta_2 PF13841.4 001293130.1_02221001_1 - 0.016 15.6 11.1 0.027 14.8 11.1 1.4 1 0 0 1 1 1 0 Beta defensin Trypan_PARP PF05887.9 001293130.1_02221001_1 - 0.098 12.6 0.8 0.13 12.2 0.8 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Defensin_1 PF00323.17 001293130.1_02221001_1 - 1.4 9.4 12.7 2.7 8.5 12.7 1.5 1 0 0 1 1 1 0 Mammalian defensin TK PF00265.16 001291393.1_02224001_3 - 1.8e-71 239.5 2.1 2.3e-71 239.2 2.1 1.1 1 0 0 1 1 1 1 Thymidine kinase Ald_Xan_dh_C2 PF02738.16 001293246.1_02229001_1 - 3.1e-193 643.0 0.0 4.1e-193 642.6 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001293246.1_02229001_1 - 6.9e-39 133.2 0.0 1.2e-38 132.3 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 001293246.1_02229001_1 - 1.6e-34 118.4 0.2 3.5e-34 117.4 0.2 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.15 001293246.1_02229001_1 - 3.3e-30 104.1 0.0 1.5e-28 98.9 0.0 2.5 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.18 001293246.1_02229001_1 - 8.8e-29 99.2 0.3 2.1e-28 97.9 0.3 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.25 001293246.1_02229001_1 - 5.5e-06 26.1 0.1 5.5e-06 26.1 0.1 2.5 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain DHODB_Fe-S_bind PF10418.7 001293246.1_02229001_1 - 0.77 9.5 10.1 0.34 10.6 3.5 2.9 2 0 0 2 2 2 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B HSP70 PF00012.18 001311332.1_37524001_1 - 1.1e-264 879.1 7.0 1.2e-264 878.9 7.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 001311332.1_37524001_1 - 2.2e-17 62.8 0.2 8e-16 57.6 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.4 001311332.1_37524001_1 - 0.0008 19.7 1.4 4.7 7.5 0.0 3.5 3 1 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.14 001311332.1_37524001_1 - 0.042 13.4 0.0 0.12 12.0 0.0 1.7 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain Radial_spoke_3 PF06098.9 001311332.1_37524001_1 - 0.67 9.1 10.1 0.14 11.3 6.7 1.5 2 0 0 2 2 2 0 Radial spoke protein 3 WD40 PF00400.30 204154.1_23523001_1 - 1.5e-20 73.0 8.1 0.002 18.8 0.1 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 204154.1_23523001_1 - 1.6e-12 47.4 3.9 4.3e-05 23.6 0.2 4.2 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 204154.1_23523001_1 - 6.4e-05 22.8 0.1 0.041 13.6 0.0 2.9 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.6 204154.1_23523001_1 - 0.0061 15.1 0.1 0.014 13.9 0.1 1.6 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.3 204154.1_23523001_1 - 0.016 14.0 0.1 0.098 11.5 0.0 2.2 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.30 001278090.1_23524001_3 - 2.6e-26 91.2 6.6 5e-06 27.0 0.0 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001278090.1_23524001_3 - 6.4e-15 55.1 3.5 1.2e-05 25.4 0.2 4.3 2 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001278090.1_23524001_3 - 2.6e-05 24.1 0.1 0.61 9.8 0.0 3.0 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 001278090.1_23524001_3 - 0.0016 17.3 0.0 0.11 11.3 0.0 2.6 2 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 001278090.1_23524001_3 - 0.0067 15.0 0.1 0.016 13.7 0.1 1.6 1 0 0 1 1 1 1 Nucleoporin Nup120/160 V-set PF07686.15 001011881.1_16122001_1 - 3e-27 94.8 4.3 5.2e-14 52.2 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 001011881.1_16122001_1 - 7.6e-13 48.8 4.6 2.3e-05 24.8 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001011881.1_16122001_1 - 9.2e-13 48.0 2.1 5e-06 26.4 0.1 2.6 3 0 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.23 001011881.1_16122001_1 - 5.1e-10 39.3 4.2 0.00028 20.9 1.9 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001011881.1_16122001_1 - 1.9e-06 28.0 9.0 0.0094 16.2 4.8 2.8 2 2 0 2 2 2 2 Immunoglobulin domain LRR_8 PF13855.4 001007488.4_23527001_2 - 2.7e-28 97.4 31.7 3.1e-11 42.7 8.7 6.7 3 1 3 7 7 7 6 Leucine rich repeat TIR PF01582.18 001007488.4_23527001_2 - 3.6e-25 88.6 0.3 7.2e-25 87.7 0.3 1.5 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.5 001007488.4_23527001_2 - 1.3e-23 82.4 31.8 1.8e-05 24.8 3.0 8.1 3 3 6 9 9 9 9 Leucine Rich repeats (2 copies) TIR_2 PF13676.4 001007488.4_23527001_2 - 2e-09 37.6 0.0 3.7e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 TIR domain LRR_6 PF13516.4 001007488.4_23527001_2 - 6e-07 28.9 33.4 0.69 10.0 0.3 10.6 11 0 0 11 11 11 3 Leucine Rich repeat LRR_1 PF00560.31 001007488.4_23527001_2 - 1.2e-05 25.0 32.8 5 7.9 0.0 11.5 11 1 0 11 11 11 1 Leucine Rich Repeat LRR_9 PF14580.4 001007488.4_23527001_2 - 0.00045 19.6 8.5 0.6 9.4 0.3 3.5 2 1 0 3 3 3 3 Leucine-rich repeat LRRCT PF01463.22 001007488.4_23527001_2 - 0.11 12.9 0.0 0.45 11.1 0.0 2.2 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain V_ATPase_I PF01496.17 001080102.2_23527001_2 - 0 1110.5 10.4 0 1110.3 10.4 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Adeno_E3_CR2 PF02439.13 001080102.2_23527001_3 - 1.7 8.4 7.1 3.2 7.4 7.1 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 PP2C PF00481.19 201488.1_16126001_2 - 6.4e-75 252.0 0.1 6.7e-57 192.9 0.1 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C DUF4300 PF14133.4 201488.1_16126001_2 - 0.0012 18.5 0.5 0.0025 17.4 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4300) PP2C_2 PF13672.4 201488.1_16126001_2 - 0.0061 16.1 0.0 0.033 13.7 0.0 2.2 2 2 0 2 2 2 1 Protein phosphatase 2C SET PF00856.26 001030563.3_23525001_3 - 3.9e-19 69.5 0.0 1.2e-18 67.9 0.0 1.8 2 0 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.9 001030563.3_23525001_3 - 4.3e-14 53.2 3.4 1.1e-13 51.9 3.4 1.7 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding DUF3490 PF11995.6 001030563.3_23525001_3 - 0.027 14.2 1.0 0.047 13.4 0.4 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3490) RNA_pol_Rpo13 PF12136.6 001030563.3_23525001_3 - 0.12 12.2 3.8 0.21 11.4 0.2 2.4 2 0 0 2 2 2 0 RNA polymerase Rpo13 subunit HTH domain C2 PF00168.28 001199643.2_23529001_1 - 1e-21 77.0 0.0 2.3e-13 50.2 0.1 2.3 2 0 0 2 2 2 2 C2 domain PI3K_C2 PF00792.22 001199643.2_23529001_1 - 0.011 15.7 0.0 0.32 10.9 0.0 2.3 2 0 0 2 2 2 0 Phosphoinositide 3-kinase C2 2OG-FeII_Oxy_4 PF13661.4 001199643.2_23529001_1 - 0.12 12.9 0.1 0.28 11.7 0.1 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily P5CR_dimer PF14748.4 001292071.1_23525001_1 - 1.3e-36 124.8 0.0 2.6e-36 123.8 0.0 1.5 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.15 001292071.1_23525001_1 - 1.5e-18 67.1 0.0 2.4e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Rossmann-like PF10727.7 001292071.1_23525001_1 - 0.02 14.6 0.1 0.04 13.6 0.1 1.4 1 0 0 1 1 1 0 Rossmann-like domain ApbA PF02558.14 001292071.1_23525001_1 - 0.082 12.4 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA RRS1 PF04939.10 200062.1_16123001_1 - 1.3e-60 203.8 13.3 1.3e-60 203.8 13.3 2.1 2 1 1 3 3 3 1 Ribosome biogenesis regulatory protein (RRS1) Fructosamin_kin PF03881.12 200062.1_16123001_1 - 0.049 12.7 0.0 0.073 12.1 0.0 1.2 1 0 0 1 1 1 0 Fructosamine kinase BNR_2 PF13088.4 001293111.1_02223001_1 - 4.9e-40 137.4 0.0 6.1e-40 137.1 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.4 001293111.1_02223001_1 - 2e-08 33.8 0.0 2.7e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.18 001293111.1_02223001_1 - 0.001 18.6 6.6 0.032 14.1 0.3 3.3 3 0 0 3 3 3 2 BNR/Asp-box repeat 7tm_1 PF00001.19 001293118.1_02223001_1 - 2.8e-43 148.0 10.9 3.9e-43 147.5 10.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001293118.1_02223001_1 - 1.3e-08 34.4 5.6 1.3e-08 34.4 5.6 2.4 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.7 001293118.1_02223001_1 - 2e-07 30.5 5.1 2e-07 30.5 5.1 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 001293118.1_02223001_1 - 4e-07 29.5 12.3 5.6e-07 29.1 12.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001293118.1_02223001_1 - 5.1e-06 26.3 11.0 0.00012 21.8 11.0 2.1 1 1 0 1 1 1 1 Olfactory receptor Filament PF00038.19 001293121.1_02224001_1 - 8.4e-109 363.8 31.7 9.8e-109 363.6 31.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001293121.1_02224001_1 - 7.3e-13 48.9 30.6 2.2e-11 44.1 1.2 3.2 2 1 1 3 3 3 2 Keratin type II head TPR_MLP1_2 PF07926.10 001293121.1_02224001_1 - 5.5e-08 32.8 21.1 0.0015 18.5 0.0 3.4 3 0 0 3 3 3 2 TPR/MLP1/MLP2-like protein DASH_Spc19 PF08287.9 001293121.1_02224001_1 - 0.0041 16.9 1.0 0.0041 16.9 1.0 2.8 2 1 1 3 3 3 1 Spc19 DUF4924 PF16271.3 001293121.1_02224001_1 - 0.0044 16.9 1.4 0.0044 16.9 1.4 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4924) Spc7 PF08317.9 001293121.1_02224001_1 - 0.029 13.1 29.4 0.54 8.9 11.8 3.0 1 1 1 2 2 2 0 Spc7 kinetochore protein Tup_N PF08581.8 001293121.1_02224001_1 - 0.15 12.2 0.1 0.15 12.2 0.1 4.8 2 2 3 5 5 5 0 Tup N-terminal CENP-F_leu_zip PF10473.7 001293121.1_02224001_1 - 0.16 11.9 27.6 1.4 8.8 10.6 3.5 1 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.12 001293121.1_02224001_1 - 0.25 11.0 28.4 0.11 12.2 6.1 3.1 2 1 1 3 3 3 0 IncA protein LPP PF04728.11 001293121.1_02224001_1 - 0.6 10.4 3.7 8.7 6.7 0.2 3.6 4 0 0 4 4 4 0 Lipoprotein leucine-zipper BRE1 PF08647.9 001293121.1_02224001_1 - 0.78 9.7 26.4 0.052 13.5 5.7 4.4 2 2 1 3 3 3 0 BRE1 E3 ubiquitin ligase Tropomyosin_1 PF12718.5 001293121.1_02224001_1 - 1.1 9.3 27.3 0.28 11.2 10.2 3.2 2 1 1 3 3 3 0 Tropomyosin like DUF4164 PF13747.4 001293121.1_02224001_1 - 1.1 9.4 16.4 1.6 8.9 0.6 3.6 2 2 1 3 3 3 0 Domain of unknown function (DUF4164) DASH_Duo1 PF08651.8 001293121.1_02224001_1 - 1.4 8.6 5.8 9.9 5.9 0.3 3.3 2 1 1 3 3 3 0 DASH complex subunit Duo1 ZapB PF06005.10 001293121.1_02224001_1 - 1.6 9.1 19.1 0.4 11.0 4.0 3.9 3 2 1 4 4 4 0 Cell division protein ZapB CHDCT2 PF08074.9 001293121.1_02224001_1 - 1.8 8.6 12.9 0.21 11.6 1.5 2.8 1 1 1 3 3 3 0 CHDCT2 (NUC038) domain DUF4407 PF14362.4 001293121.1_02224001_1 - 4.5 6.4 14.5 7 5.8 0.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Jnk-SapK_ap_N PF09744.7 001293121.1_02224001_1 - 4.8 7.3 26.3 0.21 11.7 1.1 3.3 1 1 0 3 3 3 0 JNK_SAPK-associated protein-1 ApoLp-III PF07464.9 001293121.1_02224001_1 - 5.4 7.0 10.6 0.72 9.8 1.3 3.1 2 2 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) APG6 PF04111.10 001293121.1_02224001_1 - 6.1 6.0 25.3 3.5 6.8 9.9 2.3 2 0 0 2 2 2 0 Autophagy protein Apg6 ATG16 PF08614.9 001293121.1_02224001_1 - 7 6.6 24.1 0.23 11.5 3.3 3.8 2 2 1 3 3 3 0 Autophagy protein 16 (ATG16) Filament PF00038.19 001293123.1_02224001_1 - 9.4e-100 334.1 24.8 1.1e-99 333.9 24.8 1.0 1 0 0 1 1 1 1 Intermediate filament protein Nsp1_C PF05064.11 001293123.1_02224001_1 - 9.4e-05 22.1 5.3 9.4e-05 22.1 5.3 2.8 3 1 1 4 4 4 1 Nsp1-like C-terminal region DUF2312 PF10073.7 001293123.1_02224001_1 - 0.028 13.9 0.1 0.29 10.7 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) TPR_MLP1_2 PF07926.10 001293123.1_02224001_1 - 0.038 13.9 0.1 0.038 13.9 0.1 3.3 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF45 PF01863.15 001293123.1_02224001_1 - 0.064 13.2 0.8 1.5 8.7 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function DUF45 Lzipper-MIP1 PF14389.4 001293123.1_02224001_1 - 0.45 10.7 11.7 0.038 14.1 3.1 3.1 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Baculo_PEP_C PF04513.10 001293123.1_02224001_1 - 0.6 10.0 6.5 0.95 9.4 0.8 2.9 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HALZ PF02183.16 001293123.1_02224001_1 - 0.97 9.6 8.2 12 6.0 0.9 3.9 3 0 0 3 3 3 0 Homeobox associated leucine zipper DivIC PF04977.13 001293123.1_02224001_1 - 1.9 8.2 13.3 16 5.2 0.0 4.6 5 0 0 5 5 5 0 Septum formation initiator DUF3373 PF11853.6 001293123.1_02224001_1 - 3 6.4 3.4 5.9 5.4 3.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) Phage_GPO PF05929.9 001293123.1_02224001_1 - 3.9 6.9 5.8 1.2 8.6 1.0 2.2 1 1 2 3 3 3 0 Phage capsid scaffolding protein (GPO) serine peptidase Wtap PF17098.3 001293123.1_02224001_1 - 6.1 6.7 22.9 0.9 9.3 0.6 3.1 2 1 1 3 3 3 0 WTAP/Mum2p family 7tm_1 PF00001.19 001293131.1_02223001_1 - 3.2e-39 134.7 14.8 4.4e-39 134.2 14.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001293131.1_02223001_1 - 1e-06 28.2 10.1 1e-06 28.2 10.1 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv TAS2R PF05296.11 001293131.1_02223001_1 - 0.00012 21.1 1.3 0.00012 21.1 1.3 2.4 3 0 0 3 3 3 1 Taste receptor protein (TAS2R) 7tm_4 PF13853.4 001293131.1_02223001_1 - 0.013 15.1 14.5 0.15 11.7 14.5 2.0 1 1 0 1 1 1 0 Olfactory receptor DUF1201 PF06716.9 001293131.1_02223001_1 - 3.9 7.4 7.3 8 6.4 2.6 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) Augurin PF15187.4 001136244.1_16123001_2 - 1.7e-05 24.8 0.1 2.9e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 Oesophageal cancer-related gene 4 BNR_2 PF13088.4 001293247.1_02223001_1 - 6.8e-40 137.0 0.0 9e-40 136.6 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.4 001293247.1_02223001_1 - 8.2e-10 38.3 0.0 1e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.18 001293247.1_02223001_1 - 0.02 14.7 14.8 0.03 14.1 0.5 3.7 3 0 0 3 3 3 0 BNR/Asp-box repeat Sortilin-Vps10 PF15902.3 001293247.1_02223001_1 - 0.13 10.9 0.1 3.1 6.4 0.0 2.0 2 0 0 2 2 2 0 Sortilin, neurotensin receptor 3, CHB_HEX_C PF03174.11 001293247.1_02223001_1 - 0.14 12.0 0.2 28 4.7 0.0 2.9 3 0 0 3 3 3 0 Chitobiase/beta-hexosaminidase C-terminal domain DUF4185 PF13810.4 001293247.1_02223001_1 - 0.21 10.7 0.3 3 6.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4185) Ald_Xan_dh_C2 PF02738.16 001293248.1_02229001_1 - 1.2e-193 644.4 0.0 1.5e-193 644.1 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001293248.1_02229001_1 - 4.1e-43 146.9 0.0 9.8e-43 145.7 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 001293248.1_02229001_1 - 9.5e-34 115.9 3.0 2e-33 114.9 3.0 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.15 001293248.1_02229001_1 - 3.9e-32 110.4 0.0 1.7e-31 108.3 0.0 2.1 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.18 001293248.1_02229001_1 - 9.5e-31 105.5 0.1 2.8e-30 103.9 0.1 1.9 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.25 001293248.1_02229001_1 - 1.2e-08 34.7 3.1 1.2e-08 34.7 0.1 2.7 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain Cation_efflux PF01545.19 001293283.1_23528001_3 - 9e-50 169.0 16.7 1.3e-49 168.6 16.7 1.2 1 0 0 1 1 1 1 Cation efflux family PHO4 PF01384.18 001293283.1_23528001_3 - 0.028 13.4 4.5 0.045 12.7 4.5 1.2 1 0 0 1 1 1 0 Phosphate transporter family DUF1282 PF06930.10 001293283.1_23528001_3 - 0.047 13.4 7.0 0.74 9.5 4.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1282) LRR_8 PF13855.4 001037835.1_23526001_1 - 2.1e-39 133.0 34.1 5.3e-11 42.0 0.1 8.2 3 1 5 8 8 8 8 Leucine rich repeat LRR_4 PF12799.5 001037835.1_23526001_1 - 9.5e-28 95.6 48.7 2.1e-06 27.8 0.7 10.1 11 1 1 12 12 12 8 Leucine Rich repeats (2 copies) TIR PF01582.18 001037835.1_23526001_1 - 6.6e-25 87.8 0.1 1.4e-24 86.7 0.1 1.5 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.4 001037835.1_23526001_1 - 5.6e-11 42.5 0.0 1.2e-10 41.5 0.0 1.5 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.31 001037835.1_23526001_1 - 4.3e-09 35.4 31.1 0.19 12.2 0.0 13.5 11 5 2 13 13 13 3 Leucine Rich Repeat LRR_9 PF14580.4 001037835.1_23526001_1 - 0.0014 18.0 12.9 0.38 10.1 0.6 4.8 3 1 1 4 4 4 2 Leucine-rich repeat LRR_5 PF13306.4 001037835.1_23526001_1 - 0.028 14.3 21.5 0.34 10.7 0.1 4.5 3 1 1 4 4 4 0 Leucine rich repeats (6 copies) FNIP PF05725.10 001037835.1_23526001_1 - 0.37 10.9 16.0 0.83 9.7 0.4 5.5 5 0 0 5 5 5 0 FNIP Repeat LRR_6 PF13516.4 001037835.1_23526001_1 - 1.6 8.9 47.2 1.1 9.4 0.1 11.9 15 0 0 15 15 15 0 Leucine Rich repeat PARP PF00644.18 001245984.1_16121001_1 - 9.1e-08 31.9 0.0 1.1e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Exotox-A_cataly PF09009.8 001245984.1_16121001_1 - 0.0017 17.4 0.0 0.0022 17.0 0.0 1.2 1 0 0 1 1 1 1 Exotoxin A catalytic MHC_I PF00129.16 200406.1_16124001_3 - 3.6e-35 121.0 0.1 5.1e-35 120.5 0.1 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 200406.1_16124001_3 - 1.6e-17 63.6 0.1 3.9e-17 62.4 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin C1-set domain CD99L2 PF12301.6 200406.1_16124001_3 - 0.00049 20.3 0.0 0.00049 20.3 0.0 1.5 2 0 0 2 2 2 1 CD99 antigen like protein 2 C2-set_2 PF08205.10 200406.1_16124001_3 - 0.00053 19.9 0.1 0.00092 19.1 0.1 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain MHC_II_alpha PF00993.18 200406.1_16124001_3 - 0.0042 16.6 0.5 2.1 8.0 0.2 2.4 2 0 0 2 2 2 2 Class II histocompatibility antigen, alpha domain ETRAMP PF09716.8 200406.1_16124001_3 - 0.033 14.1 11.3 0.042 13.8 0.0 2.8 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) MHC_II_beta PF00969.17 200406.1_16124001_3 - 0.047 13.7 0.1 0.85 9.7 0.0 2.4 2 0 0 2 2 2 0 Class II histocompatibility antigen, beta domain Syndecan PF01034.18 200406.1_16124001_3 - 0.12 12.2 1.2 0.37 10.6 1.2 1.8 1 0 0 1 1 1 0 Syndecan domain Protocadherin PF08374.9 200406.1_16124001_3 - 0.15 11.9 0.0 0.15 11.9 0.0 2.2 2 0 0 2 2 2 0 Protocadherin PKK PF12474.6 001305209.1_23529001_2 - 4.6e-68 227.5 105.2 8.2e-39 132.7 45.9 4.4 4 0 0 4 4 4 2 Polo kinase kinase Pkinase PF00069.23 001305209.1_23529001_2 - 9.7e-67 225.0 0.0 9.7e-67 225.0 0.0 2.6 3 1 1 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.15 001305209.1_23529001_2 - 3.5e-50 170.6 0.6 1.8e-49 168.2 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase 7tm_1 PF00001.19 001301381.1_37523001_1 - 1.8e-57 194.5 22.4 2.5e-57 194.0 22.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001301381.1_37523001_1 - 3.3e-12 46.2 21.8 4.1e-12 45.9 21.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001301381.1_37523001_1 - 0.0019 17.9 21.6 0.014 15.0 21.6 2.3 1 1 0 1 1 1 1 Olfactory receptor TNF PF00229.16 001297626.1_37523001_2 - 2.6e-17 62.8 0.5 8e-17 61.2 0.2 1.9 2 0 0 2 2 2 1 TNF(Tumour Necrosis Factor) family APP_Cu_bd PF12924.5 001297626.1_37523001_3 - 0.03 14.9 0.9 0.062 13.9 0.9 1.5 1 0 0 1 1 1 0 Copper-binding of amyloid precursor, CuBD 7tm_1 PF00001.19 001301378.1_37523001_1 - 2e-57 194.3 21.9 3e-57 193.7 21.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001301378.1_37523001_1 - 1.7e-11 43.8 21.2 2.3e-11 43.4 21.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001301378.1_37523001_1 - 0.0015 18.2 20.3 0.0043 16.7 20.3 1.9 1 1 0 1 1 1 1 Olfactory receptor Homeobox PF00046.27 001267719.1_23522001_1 - 1.7e-22 78.8 7.3 2.6e-22 78.3 7.3 1.3 1 0 0 1 1 1 1 Homeobox domain Engrail_1_C_sig PF10525.7 001267719.1_23522001_1 - 2e-17 61.9 1.6 4.1e-17 61.0 1.6 1.5 1 0 0 1 1 1 1 Engrailed homeobox C-terminal signature domain Homeobox_KN PF05920.9 001267719.1_23522001_1 - 0.00052 19.7 3.2 0.0042 16.8 2.8 2.6 2 1 0 2 2 2 1 Homeobox KN domain CENP-B_N PF04218.11 001267719.1_23522001_1 - 0.0053 16.2 0.2 0.013 15.0 0.1 1.6 1 1 0 1 1 1 1 CENP-B N-terminal DNA-binding domain DUF2316 PF10078.7 001267719.1_23522001_1 - 0.0059 16.7 0.6 0.01 16.0 0.6 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2316) BAR_3_WASP_bdg PF10456.7 001030124.1_16126001_2 - 8.9e-119 395.0 3.6 1.2e-118 394.7 3.6 1.1 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PX PF00787.22 001030124.1_16126001_2 - 1.4e-19 70.0 0.0 3.3e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 PX domain SH3_1 PF00018.26 001030124.1_16126001_2 - 8.5e-11 41.2 0.1 5.1e-10 38.7 0.0 2.3 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 001030124.1_16126001_2 - 6.4e-09 35.4 0.0 2e-08 33.8 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001030124.1_16126001_2 - 2.1e-07 30.4 0.0 4.3e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Vps5 PF09325.8 001030124.1_16126001_2 - 2.1e-05 24.1 0.2 0.028 13.9 0.5 2.2 1 1 1 2 2 2 2 Vps5 C terminal like Porin_3 PF01459.20 200217.2_16129001_3 - 1.2e-80 270.8 8.1 1.6e-80 270.3 8.1 1.2 1 0 0 1 1 1 1 Eukaryotic porin Mito_fiss_reg PF05308.9 204543.2_23526001_1 - 4.6e-82 275.6 3.0 6.2e-82 275.2 3.0 1.2 1 0 0 1 1 1 1 Mitochondrial fission regulator FlxA PF14282.4 204543.2_23526001_1 - 0.098 12.5 0.4 0.19 11.6 0.4 1.4 1 0 0 1 1 1 0 FlxA-like protein CAP_N PF01213.17 204543.2_23526001_1 - 0.67 9.2 6.8 1.1 8.5 6.8 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.3 204543.2_23526001_1 - 4.2 7.3 12.7 8.9 6.2 12.7 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 UCH PF00443.27 001305103.1_23526001_1 - 2.2e-47 161.6 0.0 3e-47 161.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.29 001305103.1_23526001_1 - 1.1e-24 85.8 0.1 3.5e-12 45.8 0.0 3.2 3 0 0 3 3 3 2 UBA/TS-N domain zf-UBP PF02148.17 001305103.1_23526001_1 - 6.8e-15 55.0 0.4 2.2e-12 47.0 0.0 2.7 3 0 0 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.4 001305103.1_23526001_1 - 8.9e-11 41.8 0.0 1e-09 38.3 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA_4 PF14555.4 001305103.1_23526001_1 - 0.014 15.1 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain BNR PF02012.18 001305123.1_23529001_3 - 6.8e-29 94.9 51.9 0.36 10.9 0.2 16.2 15 0 0 15 15 15 13 BNR/Asp-box repeat EGF_2 PF07974.11 001305123.1_23529001_3 - 2.4e-24 85.3 152.6 6.2e-05 23.1 11.4 9.3 8 0 0 8 8 8 8 EGF-like domain CHB_HEX_C PF03174.11 001305123.1_23529001_3 - 2.2e-08 33.8 3.4 53 3.8 0.0 11.9 14 0 0 14 14 14 0 Chitobiase/beta-hexosaminidase C-terminal domain Reeler PF02014.14 001305123.1_23529001_3 - 1.1e-07 32.5 0.0 4.8e-07 30.4 0.0 2.2 1 0 0 1 1 1 1 Reeler domain hEGF PF12661.5 001305123.1_23529001_3 - 0.0031 18.0 9.0 0.0031 18.0 9.0 9.9 10 0 0 10 10 10 4 Human growth factor-like EGF EB PF01683.16 001305123.1_23529001_3 - 1.1 9.5 91.0 0.031 14.4 3.5 9.7 9 0 0 9 9 9 0 EB module Sortilin-Vps10 PF15902.3 001305123.1_23529001_3 - 2.8 6.5 11.1 42 2.6 0.0 7.3 12 0 0 12 12 12 0 Sortilin, neurotensin receptor 3, Ion_trans PF00520.29 001305147.1_23529001_1 - 1.4e-253 836.5 85.1 2e-71 239.9 17.6 4.1 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.3 001305147.1_23529001_1 - 9.3e-36 121.3 0.0 2.1e-35 120.2 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 001305147.1_23529001_1 - 5.5e-29 100.1 0.1 1.4e-28 98.8 0.1 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 001305147.1_23529001_1 - 1.1e-10 40.7 25.2 3.7e-09 35.6 7.6 8.5 7 3 2 9 9 9 3 Polycystin cation channel CAC1F_C PF16885.3 001305147.1_23529001_1 - 9.8e-10 38.5 1.7 2.3e-08 34.0 0.2 2.4 2 0 0 2 2 2 1 Voltage-gated calcium channel subunit alpha, C-term DUF2670 PF10875.6 001305147.1_23529001_1 - 0.2 11.6 2.9 0.6 10.1 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2670) Glyco_transf_64 PF09258.8 001305438.1_23526001_1 - 1.3e-97 325.9 0.2 1.8e-97 325.4 0.2 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.13 001305438.1_23526001_1 - 1.7e-56 191.5 0.0 2.3e-56 191.1 0.0 1.2 1 0 0 1 1 1 1 Exostosin family Mob1_phocein PF03637.15 001031557.2_23526001_2 - 1.5e-32 112.8 0.7 2.8e-32 112.0 0.7 1.3 1 0 0 1 1 1 1 Mob1/phocein family zf-TRAF PF02176.16 001006191.2_23526001_1 - 0.001 19.6 33.4 0.0015 19.1 5.8 5.1 4 1 1 5 5 5 3 TRAF-type zinc finger PRP21_like_P PF12230.6 001006191.2_23526001_1 - 1.7 8.4 7.3 0.65 9.7 1.0 2.9 2 1 0 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein FGF PF00167.16 001031546.2_23522001_1 - 3.4e-42 143.3 0.0 4.2e-42 143.1 0.0 1.1 1 0 0 1 1 1 1 Fibroblast growth factor Metal_resist PF13801.4 001031546.2_23522001_1 - 0.19 11.8 4.4 0.27 11.2 4.4 1.2 1 0 0 1 1 1 0 Heavy-metal resistance Mito_carr PF00153.25 001252068.2_23527001_2 - 2.7e-62 206.6 1.6 5.9e-24 83.7 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Gag_p6 PF08705.9 001031377.2_23526001_1 - 0.0071 16.4 3.4 0.017 15.2 3.4 1.6 1 0 0 1 1 1 1 Gag protein p6 FAM76 PF16046.3 001031377.2_23526001_3 - 6.9e-113 376.8 40.9 8.6e-113 376.5 40.9 1.1 1 0 0 1 1 1 1 FAM76 protein GHL13 PF14883.4 001031377.2_23526001_3 - 0.02 13.9 3.0 0.03 13.3 3.0 1.2 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 MCU PF04678.11 001031377.2_23526001_3 - 0.34 10.9 3.9 0.63 10.0 3.9 1.4 1 0 0 1 1 1 0 Mitochondrial calcium uniporter MPS2 PF17060.3 001031377.2_23526001_3 - 0.6 9.2 10.1 1.4 8.0 10.1 1.5 1 1 0 1 1 1 0 Monopolar spindle protein 2 CorA PF01544.16 001031377.2_23526001_3 - 0.87 8.7 2.9 1.3 8.1 2.9 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF16 PF01519.14 001031377.2_23526001_3 - 1.6 9.1 7.2 3.7 8.0 7.2 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 DUF3552 PF12072.6 001031377.2_23526001_3 - 2.5 7.4 15.8 4.4 6.5 15.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF2968 PF11180.6 001031377.2_23526001_3 - 3.9 7.0 11.2 7 6.2 11.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) DUF148 PF02520.15 001031377.2_23526001_3 - 4.3 7.4 11.3 5.5 7.0 2.7 2.4 1 1 1 2 2 2 0 Domain of unknown function DUF148 EMP24_GP25L PF01105.22 001308001.1_23525001_2 - 7.3e-42 143.2 0.3 9.4e-42 142.9 0.3 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4665 PF15679.3 001308001.1_23525001_2 - 0.1 13.1 1.8 0.22 12.0 1.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4665) DUF4207 PF13904.4 001045845.2_16123001_2 - 9.4e-30 104.0 42.4 1.5e-29 103.3 42.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) Borrelia_P83 PF05262.9 001045845.2_16123001_2 - 0.24 9.7 36.2 0.31 9.3 36.2 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein MIP-T3 PF10243.7 001045845.2_16123001_2 - 1.9 7.0 43.2 3.4 6.1 43.2 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Pkinase_Tyr PF07714.15 001311315.1_37525001_1 - 7.3e-103 343.2 0.0 1e-102 342.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001311315.1_37525001_1 - 6.9e-44 150.1 0.0 1.1e-43 149.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 001311315.1_37525001_1 - 7e-36 122.0 0.2 4.7e-14 52.1 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 001311315.1_37525001_1 - 4.7e-35 119.9 0.6 5.8e-12 45.9 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001311315.1_37525001_1 - 9.5e-26 89.8 1.2 2.4e-11 43.7 0.1 3.6 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 001311315.1_37525001_1 - 6.5e-23 80.6 1.3 1.4e-07 31.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001311315.1_37525001_1 - 4.5e-17 62.1 1.8 9.6e-05 22.4 0.0 4.3 3 2 0 3 3 3 3 Immunoglobulin V-set domain Ig_5 PF16681.3 001311315.1_37525001_1 - 2.8e-07 30.7 0.4 0.038 14.3 0.0 4.0 3 1 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 001311315.1_37525001_1 - 0.00016 21.5 0.2 0.046 13.7 0.0 3.4 2 1 1 3 3 3 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 001311315.1_37525001_1 - 0.027 14.4 0.0 23 5.0 0.0 3.4 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.9 001311315.1_37525001_1 - 0.091 12.6 0.1 1.7 8.5 0.0 2.7 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain ecTbetaR2 PF08917.8 001311326.1_37524001_1 - 1.5e-38 131.0 14.7 4.2e-38 129.5 14.7 1.8 1 0 0 1 1 1 1 Transforming growth factor beta receptor 2 ectodomain Pkinase PF00069.23 001311326.1_37524001_1 - 1.2e-34 119.8 0.0 1.7e-34 119.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001311326.1_37524001_1 - 4.4e-33 114.5 0.2 1e-32 113.3 0.2 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001311326.1_37524001_1 - 0.0068 16.2 0.1 0.012 15.5 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family FlaC_arch PF05377.9 001311326.1_37524001_1 - 0.22 11.8 2.3 0.6 10.4 2.3 1.8 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Pkinase PF00069.23 001311329.1_37523001_1 - 3.9e-36 124.6 0.0 5.3e-36 124.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001311329.1_37523001_1 - 1.8e-35 122.4 0.1 4.3e-35 121.1 0.1 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase TGF_beta_GS PF08515.10 001311329.1_37523001_1 - 2e-17 62.2 0.4 5.1e-17 60.9 0.4 1.7 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.21 001311329.1_37523001_1 - 8.2e-11 42.7 9.7 8.2e-11 42.7 9.7 1.9 2 0 0 2 2 2 1 Activin types I and II receptor domain APH PF01636.21 001311329.1_37523001_1 - 0.013 15.3 0.0 0.03 14.1 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.4 001311329.1_37523001_1 - 0.075 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 HLH PF00010.24 001311330.1_37522001_1 - 2.7e-14 52.7 2.0 4.7e-14 51.9 2.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain MIP PF00230.18 001311333.1_37523001_3 - 2.6e-47 161.3 10.3 3.6e-47 160.8 10.3 1.1 1 0 0 1 1 1 1 Major intrinsic protein Tachykinin PF02202.14 001311342.1_37521001_1 - 0.038 13.7 0.9 0.41 10.5 0.2 2.4 2 0 0 2 2 2 0 Tachykinin family BNR_2 PF13088.4 001311339.1_37523001_1 - 5.7e-42 143.8 0.0 7.2e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.4 001311339.1_37523001_1 - 2e-07 30.5 0.0 1.2e-06 27.9 0.0 2.0 1 1 1 2 2 2 2 BNR repeat-like domain BNR PF02012.18 001311339.1_37523001_1 - 4.2e-05 22.8 13.8 0.26 11.3 0.2 5.4 5 0 0 5 5 5 3 BNR/Asp-box repeat LRR_9 PF14580.4 001282091.1_02222001_1 - 2e-14 53.3 0.1 4.6e-14 52.2 0.1 1.6 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.5 001282091.1_02222001_1 - 3e-07 30.5 16.6 5.2e-05 23.4 2.0 3.9 1 1 3 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001282091.1_02222001_1 - 1.7e-06 27.5 2.9 1.7e-06 27.5 2.9 2.5 3 0 0 3 3 3 1 Leucine rich repeat LRR_1 PF00560.31 001282091.1_02222001_1 - 7.4 7.3 8.8 53 4.8 0.0 4.0 4 1 1 5 5 5 0 Leucine Rich Repeat RNase_H PF00075.22 001286010.1_02223001_3 - 2.5e-44 150.8 0.1 4.6e-44 150.0 0.1 1.4 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.14 001286010.1_02223001_3 - 7.8e-19 67.6 3.9 1.8e-18 66.5 3.9 1.7 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.4 001286010.1_02223001_3 - 0.0011 18.5 0.0 0.0069 16.0 0.0 2.2 3 0 0 3 3 3 1 Reverse transcriptase-like Ribosomal_S7e PF01251.16 001286012.1_02222001_2 - 1.9e-93 311.2 4.8 2.1e-93 311.0 4.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e IL1 PF00340.17 001290418.1_16123001_1 - 1.7e-08 34.0 0.0 3.9e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 Interleukin-1 / 18 PDZ PF00595.22 001290418.1_16123001_1 - 0.14 12.4 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) COesterase PF00135.26 001291388.1_02225001_1 - 3.8e-194 646.3 0.0 4.5e-194 646.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001291388.1_02225001_1 - 2.6e-07 30.6 0.2 1.6e-06 28.0 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 001291388.1_02225001_1 - 0.013 14.8 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family COesterase PF00135.26 001291389.1_02226001_1 - 1.5e-193 644.3 0.0 1.8e-193 644.0 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001291389.1_02226001_1 - 7.1e-05 22.6 0.1 0.00042 20.1 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF4519 PF15012.4 001291899.1_16123001_1 - 6.1e-26 90.2 2.0 9.3e-26 89.6 2.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4519) DUF4448 PF14610.4 001291899.1_16123001_1 - 0.01 15.5 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Transcrip_reg PF01709.18 001316971.1_16123001_3 - 2.2e-61 207.2 0.0 2.6e-61 207.0 0.0 1.1 1 0 0 1 1 1 1 Transcriptional regulator ADH_zinc_N PF00107.24 001316971.1_16123001_3 - 0.083 12.7 0.0 0.29 10.9 0.0 1.8 2 0 0 2 2 2 0 Zinc-binding dehydrogenase PHD PF00628.27 001024691.1_23524001_2 - 9.5e-07 28.5 5.7 1.8e-06 27.6 5.7 1.5 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.4 001024691.1_23524001_2 - 0.0039 16.9 1.1 0.0089 15.8 1.1 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 Macoilin PF09726.7 001024691.1_23524001_2 - 6.6 5.0 10.7 8.7 4.6 10.7 1.1 1 0 0 1 1 1 0 Transmembrane protein LRR_8 PF13855.4 001139478.1_23523001_1 - 2.9e-18 65.2 8.7 3.2e-05 23.5 0.7 4.7 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 001139478.1_23523001_1 - 1.2e-15 57.1 9.6 0.00067 19.8 1.9 5.4 2 2 4 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001139478.1_23523001_1 - 2.2e-06 27.2 14.1 0.62 10.6 0.2 6.1 5 2 0 5 5 5 4 Leucine Rich Repeat LRR_6 PF13516.4 001139478.1_23523001_1 - 0.00052 19.7 19.2 0.75 9.9 0.0 6.6 7 1 1 8 8 8 4 Leucine Rich repeat LRRCT PF01463.22 001139478.1_23523001_1 - 0.025 15.0 0.5 0.23 12.0 0.1 3.0 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain Forkhead PF00250.16 204770.1_23525001_1 - 4.9e-37 126.0 0.2 8.6e-37 125.2 0.2 1.4 1 0 0 1 1 1 1 Forkhead domain HNF_C PF09354.8 204770.1_23525001_1 - 1.5e-25 89.9 11.5 1.5e-25 89.9 11.5 3.8 2 1 0 2 2 2 1 HNF3 C-terminal domain Forkhead_N PF08430.10 204770.1_23525001_1 - 3.3e-25 89.1 45.4 3.3e-25 89.1 45.4 2.5 3 0 0 3 3 3 1 Forkhead N-terminal region HLH PF00010.24 001318463.1_23523001_3 - 3.2e-17 62.1 0.1 5.5e-17 61.3 0.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF2353 PF09789.7 001318463.1_23523001_3 - 0.01 15.2 1.8 0.014 14.7 1.8 1.1 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) GAS PF13851.4 001318463.1_23523001_3 - 0.02 14.1 4.0 0.032 13.5 4.0 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Rootletin PF15035.4 001318463.1_23523001_3 - 0.022 14.7 5.3 0.035 14.1 5.3 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF972 PF06156.11 001318463.1_23523001_3 - 0.025 15.1 0.5 0.048 14.1 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) ZapB PF06005.10 001318463.1_23523001_3 - 0.074 13.4 9.4 1.4 9.2 9.4 2.4 1 1 0 1 1 1 0 Cell division protein ZapB MAD PF05557.11 001318463.1_23523001_3 - 0.11 10.7 4.9 0.14 10.4 4.9 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein KLRAQ PF10205.7 001318463.1_23523001_3 - 0.21 11.7 4.3 0.38 10.9 4.3 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein IncA PF04156.12 001318463.1_23523001_3 - 0.51 10.0 3.5 0.71 9.5 3.5 1.2 1 0 0 1 1 1 0 IncA protein MCC-bdg_PDZ PF10506.7 001318463.1_23523001_3 - 0.72 9.8 4.3 0.55 10.2 1.0 2.2 1 1 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome HALZ PF02183.16 001318463.1_23523001_3 - 7.1 6.8 7.9 2.4 8.3 3.3 2.2 1 1 1 2 2 2 0 Homeobox associated leucine zipper Smg4_UPF3 PF03467.13 001318462.1_23524001_3 - 1.5e-55 187.8 5.3 1.5e-55 187.8 5.3 4.8 1 1 1 2 2 2 1 Smg-4/UPF3 family RRM_1 PF00076.20 001318462.1_23524001_3 - 0.036 13.7 0.0 0.12 12.1 0.0 2.0 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) adh_short PF00106.23 001318839.1_23522001_2 - 7.3e-30 103.8 0.0 1.5e-29 102.7 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001318839.1_23522001_2 - 1.5e-21 76.9 0.0 2.3e-21 76.3 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001318839.1_23522001_2 - 7.1e-08 32.4 0.0 1.2e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.4 001318839.1_23522001_2 - 0.065 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Band_7_C PF16200.3 001318839.1_23522001_2 - 0.098 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of band_7 Ig_2 PF13895.4 001146134.1_23522001_1 - 1.5e-16 60.3 0.3 2e-07 31.1 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001146134.1_23522001_1 - 3.6e-15 56.2 0.2 3.9e-07 30.5 0.1 3.0 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 001146134.1_23522001_1 - 6.6e-12 45.3 2.1 1e-06 28.7 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001146134.1_23522001_1 - 6.1e-07 29.4 1.4 0.0045 17.0 0.1 4.5 3 2 1 4 4 4 1 Immunoglobulin V-set domain I-set PF07679.14 001146134.1_23522001_1 - 0.0036 17.2 0.0 0.38 10.7 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin I-set domain Izumo-Ig PF16706.3 001146134.1_23522001_1 - 0.0056 16.6 0.0 2.3 8.2 0.0 2.9 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain PRIMA1 PF16101.3 001146134.1_23522001_1 - 0.0089 15.9 0.2 0.0089 15.9 0.2 2.5 1 1 0 2 2 2 1 Proline-rich membrane anchor 1 SUR7 PF06687.10 001146134.1_23522001_1 - 0.02 14.4 0.0 0.021 14.4 0.0 1.1 1 0 0 1 1 1 0 SUR7/PalI family Herpes_gE PF02480.14 001146134.1_23522001_1 - 0.095 11.3 0.0 0.16 10.6 0.0 1.4 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Syndecan PF01034.18 001146134.1_23522001_1 - 0.2 11.5 0.3 0.49 10.2 0.3 1.6 1 0 0 1 1 1 0 Syndecan domain SRCR PF00530.16 001318983.1_23526001_1 - 1.7e-294 952.5 117.1 5.3e-33 113.4 5.3 9.0 9 0 0 9 9 9 9 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.4 001318983.1_23526001_1 - 1.3e-44 150.5 50.8 8.9e-05 22.8 0.3 9.4 9 0 0 9 9 9 9 Scavenger receptor cysteine-rich domain DUF3027 PF11228.6 001318983.1_23526001_1 - 0.12 12.3 46.7 3.5 7.5 0.5 9.1 9 0 0 9 9 9 0 Protein of unknown function (DUF3027) TYW3 PF02676.12 001318983.1_23526001_1 - 9 5.4 22.6 34 3.5 0.0 7.2 8 0 0 8 8 8 0 Methyltransferase TYW3 Keratin PF02422.14 001277763.1_23521001_2 - 1.8e-42 142.8 10.5 2.5e-42 142.3 10.5 1.2 1 0 0 1 1 1 1 Keratin Pkinase PF00069.23 001199448.1_23529001_1 - 1e-63 215.0 0.7 9.7e-63 211.9 0.0 3.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 001199448.1_23529001_1 - 2.2e-30 105.7 1.0 8.3e-30 103.8 0.0 2.4 2 0 0 2 2 2 1 Protein tyrosine kinase Rho_Binding PF08912.9 001199448.1_23529001_1 - 1.9e-22 79.7 16.6 1.9e-22 79.7 16.6 13.1 3 2 9 13 13 13 1 Rho Binding PH PF00169.27 001199448.1_23529001_1 - 3.7e-05 24.0 7.8 6.6e-05 23.2 0.1 3.6 3 1 0 3 3 3 1 PH domain C1_1 PF00130.20 001199448.1_23529001_1 - 0.00048 19.8 6.0 0.001 18.8 6.0 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FPP PF05911.9 001199448.1_23529001_1 - 0.0012 17.1 30.3 0.0012 17.1 30.3 4.9 1 1 4 5 5 5 1 Filament-like plant protein, long coiled-coil APH PF01636.21 001199448.1_23529001_1 - 0.0017 18.2 0.3 0.033 14.0 0.1 2.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_C PF00433.22 001199448.1_23529001_1 - 0.0054 17.3 1.6 0.02 15.5 1.6 2.1 1 0 0 1 1 1 1 Protein kinase C terminal domain Peptidase_S49 PF01343.16 001199448.1_23529001_1 - 9.5 6.0 14.8 1.4 8.7 1.4 4.0 2 1 0 3 3 3 0 Peptidase family S49 DZR PF12773.5 001199396.1_23525001_3 - 9.3e-15 54.3 45.9 7.7e-08 32.1 20.0 3.6 3 0 0 3 3 3 3 Double zinc ribbon Ank_2 PF12796.5 001199396.1_23525001_3 - 9.5e-11 42.0 0.2 3e-09 37.2 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 001199396.1_23525001_3 - 5.6e-08 32.3 0.1 0.68 10.5 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.28 001199396.1_23525001_3 - 1.2e-07 31.7 0.7 0.16 12.3 0.1 4.2 4 0 0 4 4 4 2 Ankyrin repeat Fn3_assoc PF13287.4 001199396.1_23525001_3 - 1.4e-07 31.4 0.0 3.3e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 Fn3 associated CHB_HEX_C_1 PF13290.4 001199396.1_23525001_3 - 2.5e-06 27.3 0.0 5.8e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain Ank_4 PF13637.4 001199396.1_23525001_3 - 2.2e-05 24.8 0.0 0.0082 16.6 0.0 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) zinc_ribbon_2 PF13240.4 001199396.1_23525001_3 - 0.003 17.1 4.5 0.003 17.1 4.5 5.8 6 1 1 7 7 7 3 zinc-ribbon domain zf-RanBP PF00641.16 001199396.1_23525001_3 - 0.015 14.5 1.1 0.015 14.5 1.1 4.8 5 0 0 5 5 4 0 Zn-finger in Ran binding protein and others Ank_5 PF13857.4 001199396.1_23525001_3 - 0.019 15.2 0.1 0.48 10.8 0.0 2.7 1 1 1 2 2 2 0 Ankyrin repeats (many copies) zf-ribbon_3 PF13248.4 001199396.1_23525001_3 - 1.1 8.6 34.7 0.15 11.4 0.9 5.7 5 1 0 5 5 5 0 zinc-ribbon domain WD40 PF00400.30 001277709.1_23524001_2 - 1.2e-22 79.6 13.2 7.9e-06 26.4 0.0 6.0 5 0 0 5 5 5 5 WD domain, G-beta repeat eIF2A PF08662.9 001277709.1_23524001_2 - 0.0013 18.5 0.0 0.0039 17.0 0.0 1.8 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.5 001277709.1_23524001_2 - 0.09 13.0 0.3 6.3 7.0 0.1 3.1 1 1 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain LSM PF01423.20 001277362.1_23521001_3 - 5.3e-21 74.0 0.0 6.8e-21 73.6 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.4 001277362.1_23521001_3 - 0.14 12.2 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain DNA_pol_A_exo1 PF01612.18 001012730.2_23526001_3 - 5.1e-50 169.5 2.2 9.5e-50 168.6 2.2 1.5 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.10 001012730.2_23526001_3 - 1.3e-23 83.3 0.0 8.2e-23 80.7 0.0 2.4 2 0 0 2 2 2 1 PMC2NT (NUC016) domain HRDC PF00570.21 001012730.2_23526001_3 - 6.1e-13 48.4 0.4 1.4e-12 47.2 0.0 1.8 2 0 0 2 2 2 1 HRDC domain DUF5072 PF16807.3 001012730.2_23526001_3 - 0.097 12.6 0.1 0.21 11.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5072) DUF4230 PF14014.4 001012730.2_23526001_3 - 1.4 9.1 8.8 1.2 9.2 4.9 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF4230) TNFR_c6 PF00020.16 001199487.1_23524001_3 - 6.2e-17 61.6 47.0 1.2e-09 38.3 4.8 3.9 3 0 0 3 3 3 3 TNFR/NGFR cysteine-rich region Death PF00531.20 001199487.1_23524001_3 - 4.6e-15 55.4 0.1 9.7e-15 54.4 0.1 1.6 1 0 0 1 1 1 1 Death domain zf-Nse PF11789.6 001277463.1_23523001_3 - 2.5e-19 68.7 2.3 4.3e-19 68.0 2.3 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.4 001277463.1_23523001_3 - 8.3e-07 28.8 0.2 1.8e-06 27.7 0.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.10 001277463.1_23523001_3 - 0.00018 20.8 3.3 0.00018 20.8 3.3 1.7 1 1 1 2 2 2 1 Rtf2 RING-finger U-box PF04564.13 001277463.1_23523001_3 - 0.0098 15.9 0.1 0.028 14.5 0.1 1.7 1 1 0 1 1 1 1 U-box domain YtxH PF12732.5 001277463.1_23523001_3 - 0.5 10.8 2.2 21 5.6 2.3 2.5 1 1 0 1 1 1 0 YtxH-like protein HalX PF08663.8 001277463.1_23523001_3 - 1.7 8.9 12.7 0.14 12.3 2.8 2.5 3 0 0 3 3 3 0 HalX domain AP_endonuc_2 PF01261.22 001277570.1_23522001_1 - 1e-30 106.6 0.1 1.4e-30 106.2 0.1 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Ras PF00071.20 001277672.1_23525001_3 - 1.5e-40 138.3 0.0 1.9e-40 138.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001277672.1_23525001_3 - 1.6e-26 92.8 0.0 2.2e-26 92.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001277672.1_23525001_3 - 1.9e-08 33.8 0.0 2.5e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001277672.1_23525001_3 - 4.4e-05 22.8 0.0 5.9e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001277672.1_23525001_3 - 0.0043 17.0 0.0 0.0061 16.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 001277672.1_23525001_3 - 0.0065 16.6 0.0 0.027 14.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.7 001277672.1_23525001_3 - 0.023 14.3 0.0 0.72 9.5 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.25 001277672.1_23525001_3 - 0.089 12.2 0.0 0.55 9.6 0.0 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain PDZ PF00595.22 001277788.2_23522001_3 - 9.1e-23 80.3 0.1 1.4e-22 79.7 0.1 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001277788.2_23522001_3 - 1.6e-09 37.8 0.1 2.5e-09 37.2 0.1 1.2 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.4 001277788.2_23522001_3 - 0.018 14.9 0.0 0.029 14.3 0.0 1.2 1 0 0 1 1 1 0 Tricorn protease PDZ domain Ribosomal_L31e PF01198.17 001277755.1_23522001_2 - 6.9e-53 176.7 0.9 1.1e-52 176.0 0.9 1.4 1 0 0 1 1 1 1 Ribosomal protein L31e Vsr PF03852.13 001277755.1_23522001_2 - 0.033 13.9 0.0 0.067 12.9 0.0 1.5 1 0 0 1 1 1 0 DNA mismatch endonuclease Vsr Meleagrin PF08189.9 001317339.1_23521001_2 - 1.5e-25 88.5 13.8 2.1e-25 88.0 13.8 1.2 1 0 0 1 1 1 1 Meleagrin/Cygnin family Aminotran_5 PF00266.17 001271525.2_23524001_2 - 1.9e-53 181.6 0.0 2.6e-53 181.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V FeoC PF09012.8 001271525.2_23524001_2 - 0.013 15.4 0.1 0.41 10.6 0.0 2.9 2 0 0 2 2 2 0 FeoC like transcriptional regulator Aminotran_3 PF00202.19 001271525.2_23524001_2 - 0.12 10.9 0.0 0.23 9.9 0.0 1.4 2 0 0 2 2 2 0 Aminotransferase class-III Troponin-I_N PF11636.6 001277633.1_23522001_1 - 0.00062 19.5 1.2 0.00062 19.5 1.2 2.4 2 0 0 2 2 2 1 Troponin I residues 1-32 COMM_domain PF07258.12 001277633.1_23522001_3 - 1.9e-16 59.8 0.0 3.9e-16 58.8 0.0 1.5 1 0 0 1 1 1 1 COMM domain Peptidase_M14 PF00246.22 001199625.1_23524001_1 - 2.8e-77 260.2 0.1 3.7e-77 259.8 0.1 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.4 001199625.1_23524001_1 - 9.4e-11 41.7 0.0 1.7e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.4 001199625.1_23524001_1 - 2.4e-07 30.5 0.0 4e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.12 001199625.1_23524001_1 - 4.8e-07 29.0 0.3 8.5e-07 28.2 0.3 1.4 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Dioxygenase_C PF00775.19 001199625.1_23524001_1 - 0.025 13.9 0.0 0.047 13.0 0.0 1.4 1 0 0 1 1 1 0 Dioxygenase adh_short PF00106.23 001277118.1_23522001_3 - 4.2e-26 91.5 0.0 6.4e-26 90.9 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001277118.1_23522001_3 - 5.6e-21 75.0 0.0 8.5e-21 74.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001277118.1_23522001_3 - 4.9e-06 26.4 0.0 7.3e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.4 001277118.1_23522001_3 - 0.026 14.3 0.0 0.036 13.8 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Peptidase_C1 PF00112.21 001281490.1_23523001_1 - 7.6e-36 124.1 2.1 3.1e-33 115.6 0.9 2.1 1 1 1 2 2 2 2 Papain family cysteine protease Inhibitor_I29 PF08246.10 001281490.1_23523001_1 - 1.6e-16 60.3 0.3 4.1e-16 59.0 0.3 1.7 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 001281490.1_23523001_1 - 0.017 13.8 0.2 0.025 13.2 0.2 1.1 1 0 0 1 1 1 0 Peptidase C1-like family zf-C2H2_4 PF13894.4 001037830.2_23529001_3 - 5e-08 33.0 50.5 0.042 14.5 0.9 8.9 9 0 0 9 9 8 4 C2H2-type zinc finger zf-C2H2 PF00096.24 001037830.2_23529001_3 - 7.3e-08 32.3 39.4 0.0083 16.4 0.6 8.1 8 0 0 8 8 8 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.6 001037830.2_23529001_3 - 4.5e-05 23.5 28.9 0.097 12.9 0.3 6.1 7 0 0 7 7 6 4 Zinc-finger double-stranded RNA-binding zf-BED PF02892.13 001037830.2_23529001_3 - 7.2e-05 22.6 32.6 0.087 12.8 0.4 6.4 4 2 2 6 6 6 3 BED zinc finger DUF629 PF04780.10 001037830.2_23529001_3 - 0.00094 17.7 14.3 0.44 8.9 1.6 4.1 4 0 0 4 4 4 3 Protein of unknown function (DUF629) CpXC PF14353.4 001037830.2_23529001_3 - 0.0051 16.7 13.9 0.87 9.5 0.2 4.2 3 1 1 4 4 4 2 CpXC protein zf-met PF12874.5 001037830.2_23529001_3 - 0.013 15.8 24.7 0.54 10.6 0.3 5.9 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 001037830.2_23529001_3 - 0.016 14.8 17.9 0.94 9.2 0.4 5.4 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-RING_7 PF02591.13 001037830.2_23529001_3 - 0.026 14.6 1.5 18 5.5 0.1 4.1 3 0 0 3 3 3 0 C4-type zinc ribbon domain zf-C2H2_2 PF12756.5 001037830.2_23529001_3 - 0.056 13.7 29.3 0.52 10.6 0.6 6.0 3 2 3 6 6 6 0 C2H2 type zinc-finger (2 copies) zf-FCS PF06467.12 001037830.2_23529001_3 - 0.17 11.7 9.6 0.27 11.1 0.2 4.6 4 0 0 4 4 4 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2_aberr PF17017.3 001037830.2_23529001_3 - 4.2 7.3 37.5 0.15 12.0 0.3 5.5 5 1 1 6 6 6 0 Aberrant zinc-finger zf-C2H2_6 PF13912.4 001037830.2_23529001_3 - 6 6.8 29.5 0.56 10.1 0.6 5.4 5 0 0 5 5 5 0 C2H2-type zinc finger CD24 PF14984.4 001277735.1_23525001_2 - 0.0017 18.4 11.7 0.004 17.2 11.7 1.6 1 0 0 1 1 1 1 CD24 protein Keratin PF02422.14 001277976.1_23522001_3 - 6.5e-41 137.8 8.6 1.5e-40 136.7 8.6 1.6 1 0 0 1 1 1 1 Keratin DUF2618 PF10940.6 001012884.2_23528001_2 - 0.032 13.9 3.4 0.081 12.6 3.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2618) WD40 PF00400.30 001012884.2_23528001_3 - 8.4e-24 83.3 8.6 0.00031 21.4 0.1 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001012884.2_23528001_3 - 3.9e-05 23.7 0.1 2.4 8.4 0.0 4.3 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DAO_C PF16901.3 001012884.2_23528001_3 - 0.041 13.6 0.0 0.072 12.8 0.0 1.4 1 0 0 1 1 1 0 C-terminal domain of alpha-glycerophosphate oxidase PrmA PF06325.11 001199471.1_23525001_2 - 7.5e-11 41.8 0.0 1.2e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.4 001199471.1_23525001_2 - 1.6e-10 41.4 0.0 3.7e-10 40.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.9 001199471.1_23525001_2 - 3.3e-09 36.0 0.1 5.1e-09 35.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_31 PF13847.4 001199471.1_23525001_2 - 4.2e-09 36.2 0.1 8.9e-09 35.2 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001199471.1_23525001_2 - 8.5e-08 32.6 0.0 2.1e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001199471.1_23525001_2 - 9.2e-07 28.8 0.0 1e-05 25.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.12 001199471.1_23525001_2 - 6.2e-06 25.7 0.0 1.1e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PRMT5 PF05185.14 001199471.1_23525001_2 - 0.00038 19.5 0.1 0.0018 17.3 0.1 1.8 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_12 PF08242.10 001199471.1_23525001_2 - 0.0011 19.5 0.0 0.0022 18.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.5 001199471.1_23525001_2 - 0.0015 18.4 0.1 0.0035 17.2 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.14 001199471.1_23525001_2 - 0.0017 18.0 0.2 0.0036 17.0 0.1 1.5 2 0 0 2 2 2 1 Met-10+ like-protein TehB PF03848.12 001199471.1_23525001_2 - 0.0059 15.9 0.1 0.01 15.1 0.1 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB ATP-synt_B PF00430.16 001199471.1_23525001_2 - 0.023 14.6 0.8 0.042 13.8 0.8 1.3 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Methyltransf_16 PF10294.7 001199471.1_23525001_2 - 0.044 13.4 0.0 0.079 12.6 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase PCMT PF01135.17 001199471.1_23525001_2 - 0.047 13.3 0.0 0.085 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.18 001199471.1_23525001_2 - 0.066 12.4 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.15 001199471.1_23525001_2 - 0.081 12.3 0.1 0.14 11.5 0.1 1.3 1 0 0 1 1 1 0 Putative methyltransferase Cons_hypoth95 PF03602.13 001199471.1_23525001_2 - 0.1 12.1 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 zf-C2H2_4 PF13894.4 001199471.1_23525001_2 - 1.2 10.1 4.9 26 5.9 6.2 2.7 2 0 0 2 2 1 0 C2H2-type zinc finger BAR PF03114.16 001006524.2_23528001_2 - 7.5e-45 153.3 12.0 1e-44 152.8 12.0 1.1 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.4 001006524.2_23528001_2 - 3.4e-11 42.7 0.1 9e-11 41.3 0.1 1.7 1 1 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001006524.2_23528001_2 - 1.7e-06 27.4 0.0 3.4e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001006524.2_23528001_2 - 9.5e-06 25.1 0.0 1.9e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.3 001006524.2_23528001_2 - 0.0058 16.2 11.0 0.0075 15.9 7.4 2.2 1 1 1 2 2 2 1 BAR domain of APPL family OmpH PF03938.12 001006524.2_23528001_2 - 0.33 10.8 12.1 0.24 11.3 0.9 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Jnk-SapK_ap_N PF09744.7 001006524.2_23528001_2 - 1.8 8.6 12.0 0.094 12.8 1.5 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 BLOC1_2 PF10046.7 001006524.2_23528001_2 - 7.4 6.8 11.4 0.88 9.8 4.1 2.5 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 EF-hand_1 PF00036.30 001030568.2_23527001_3 - 1.6e-17 61.5 10.5 2.8e-05 23.2 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 001030568.2_23527001_3 - 1.8e-17 61.6 5.6 9.3e-06 25.1 0.1 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.4 001030568.2_23527001_3 - 5.3e-15 55.5 5.6 1.1e-10 41.7 1.2 3.0 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 001030568.2_23527001_3 - 1.5e-14 53.4 8.9 1.7e-08 34.0 0.2 3.8 2 2 1 3 3 3 3 EF-hand domain pair Acyltransferase PF01553.19 001030568.2_23527001_3 - 5.8e-14 51.7 0.0 9.7e-14 51.0 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase EF-hand_5 PF13202.4 001030568.2_23527001_3 - 2.5e-12 45.6 10.6 0.00076 18.8 0.2 4.0 4 0 0 4 4 4 3 EF hand EF-hand_4 PF12763.5 001030568.2_23527001_3 - 0.0078 16.0 1.0 1.6 8.6 0.0 2.8 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 001030568.2_23527001_3 - 0.062 13.5 0.1 0.2 11.8 0.2 1.7 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region JmjN PF02375.15 001030568.2_23527001_3 - 0.28 11.0 0.0 0.28 11.0 0.0 2.4 3 0 0 3 3 3 0 jmjN domain KH_6 PF15985.3 001199516.1_23522001_2 - 1.4e-16 60.4 0.0 2.8e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 KH domain FYVE PF01363.19 001045839.2_23529001_1 - 3.4e-15 55.8 18.6 3.4e-15 55.8 18.6 2.4 2 0 0 2 2 2 1 FYVE zinc finger RUN PF02759.17 001045839.2_23529001_1 - 1.4e-08 34.7 0.0 1.4e-08 34.7 0.0 5.2 4 3 0 4 4 4 1 RUN domain GOLD_2 PF13897.4 001045839.2_23529001_1 - 6.3e-05 23.4 0.0 6.3e-05 23.4 0.0 5.8 5 3 4 9 9 9 1 Golgi-dynamics membrane-trafficking BST2 PF16716.3 001045839.2_23529001_1 - 0.0047 17.3 7.5 0.0047 17.3 7.5 14.7 7 3 11 18 18 18 4 Bone marrow stromal antigen 2 Pyr_redox_2 PF07992.12 001277276.1_23524001_1 - 1.1e-29 103.4 0.0 2.8e-28 98.9 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001277276.1_23524001_1 - 7.6e-05 22.0 1.6 0.23 10.5 0.0 3.4 3 2 1 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 001277276.1_23524001_1 - 0.002 17.1 0.3 1.1 8.2 0.1 2.3 2 0 0 2 2 2 2 FAD binding domain K_oxygenase PF13434.4 001277276.1_23524001_1 - 0.0033 16.5 0.0 1.6 7.7 0.0 2.3 1 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.25 001277276.1_23524001_1 - 0.0044 17.4 1.4 3.5 8.1 0.0 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.19 001277276.1_23524001_1 - 0.0059 15.8 0.1 0.01 15.0 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.22 001277276.1_23524001_1 - 0.034 13.7 0.0 0.078 12.5 0.0 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.20 001277276.1_23524001_1 - 0.043 12.8 0.2 7.5 5.4 0.1 2.6 3 0 0 3 3 3 0 Glucose inhibited division protein A NAD_binding_8 PF13450.4 001277276.1_23524001_1 - 0.048 13.8 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.4 001277276.1_23524001_1 - 0.061 13.2 0.0 5.5 6.8 0.0 2.6 3 0 0 3 3 3 0 FAD-NAD(P)-binding HMG-CoA_red PF00368.16 204485.2_23528001_3 - 6.3e-147 489.3 0.9 8.5e-147 488.8 0.9 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sterol-sensing PF12349.6 204485.2_23528001_3 - 9.7e-17 61.1 3.5 2e-16 60.0 3.5 1.5 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.16 204485.2_23528001_3 - 2.3e-08 32.5 2.2 3.4e-08 31.9 2.2 1.2 1 0 0 1 1 1 1 Patched family RNA_pol_Rpb4 PF03874.14 204485.2_23528001_3 - 0.12 12.6 0.1 0.27 11.4 0.1 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb4 F5_F8_type_C PF00754.23 001277111.1_23526001_3 - 1e-60 203.3 3.5 2e-31 108.6 3.0 2.2 2 0 0 2 2 2 2 F5/8 type C domain EGF PF00008.25 001277111.1_23526001_3 - 6.9e-25 86.9 39.7 6.7e-09 35.8 7.4 4.0 3 0 0 3 3 3 3 EGF-like domain EGF_2 PF07974.11 001277111.1_23526001_3 - 6.5e-08 32.7 47.9 0.00047 20.3 8.9 4.2 4 0 0 4 4 4 3 EGF-like domain hEGF PF12661.5 001277111.1_23526001_3 - 6e-06 26.6 46.5 0.00034 21.0 5.8 4.7 5 0 0 5 5 5 3 Human growth factor-like EGF EGF_3 PF12947.5 001277111.1_23526001_3 - 4.4 7.5 32.6 0.28 11.3 8.7 4.2 1 1 2 3 3 3 0 EGF domain Bac_surface_Ag PF01103.21 001278030.1_23524001_2 - 1.4e-63 215.2 3.4 1.7e-63 214.9 3.4 1.1 1 0 0 1 1 1 1 Surface antigen POTRA PF07244.13 001278030.1_23524001_2 - 0.029 14.8 0.0 0.045 14.2 0.0 1.3 1 0 0 1 1 1 0 Surface antigen variable number repeat Ocular_alb PF02101.13 001277739.1_23524001_1 - 8.6e-201 666.9 7.4 1.1e-200 666.6 7.4 1.0 1 0 0 1 1 1 1 Ocular albinism type 1 protein 7tm_2 PF00002.22 001277739.1_23524001_1 - 1.2e-06 27.9 5.5 1.8e-06 27.3 5.5 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) zf-CCHH PF10283.7 001287175.1_23525001_3 - 3.6e-25 87.5 15.0 1.8e-13 50.2 2.6 2.4 2 0 0 2 2 2 2 Zinc-finger (CX5CX6HX5H) motif HUN PF08729.8 001287175.1_23525001_3 - 0.0048 16.7 9.0 0.0048 16.7 9.0 2.2 3 0 0 3 3 3 1 HPC2 and ubinuclein domain Yop-YscD_cpl PF16697.3 001287175.1_23525001_3 - 0.076 13.2 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Pkinase PF00069.23 001199439.1_23529001_1 - 3.4e-32 111.7 0.0 5.1e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001199439.1_23529001_1 - 4.4e-20 71.9 0.0 6.6e-20 71.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Sigma70_ner PF04546.11 001199439.1_23529001_1 - 1.2 8.9 7.8 2.9 7.6 7.8 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region G0-G1_switch_2 PF15103.4 001190924.3_23522001_1 - 1e-39 135.0 0.2 1.3e-39 134.6 0.2 1.1 1 0 0 1 1 1 1 G0/G1 switch protein 2 AXH PF08517.10 001199454.2_23524001_1 - 9.5e-33 113.0 0.0 1.8e-32 112.1 0.0 1.5 1 0 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) HMG_box PF00505.17 001199454.2_23524001_1 - 7.1e-15 55.1 0.9 1.3e-14 54.2 0.9 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001199454.2_23524001_1 - 5.2e-09 36.5 2.8 5.5e-09 36.4 1.6 1.7 2 0 0 2 2 2 1 HMG-box domain MATalpha_HMGbox PF04769.10 001199454.2_23524001_1 - 0.0026 17.0 0.1 0.0047 16.1 0.1 1.3 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box UEV PF05743.11 001277415.1_23523001_1 - 5.8e-47 158.4 1.8 1.8e-46 156.8 0.3 2.1 2 0 0 2 2 2 1 UEV domain Vps23_core PF09454.8 001277415.1_23523001_1 - 4.9e-28 96.7 0.1 8.4e-28 96.0 0.1 1.4 1 0 0 1 1 1 1 Vps23 core domain UQ_con PF00179.24 001277415.1_23523001_1 - 0.00028 20.4 0.4 0.00028 20.4 0.4 1.7 2 0 0 2 2 1 1 Ubiquitin-conjugating enzyme APG6 PF04111.10 001277415.1_23523001_1 - 0.00086 18.7 4.4 0.0013 18.1 4.4 1.3 1 0 0 1 1 1 1 Autophagy protein Apg6 DUF3450 PF11932.6 001277415.1_23523001_1 - 0.0019 17.4 8.5 0.0019 17.4 8.5 1.5 2 0 0 2 2 1 1 Protein of unknown function (DUF3450) GPS2_interact PF15784.3 001277415.1_23523001_1 - 0.015 15.8 7.3 0.039 14.5 7.3 1.7 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain Macoilin PF09726.7 001277415.1_23523001_1 - 0.021 13.3 3.3 0.03 12.8 3.3 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF1640 PF07798.9 001277415.1_23523001_1 - 0.031 14.2 8.3 0.036 14.0 7.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) ERM PF00769.17 001277415.1_23523001_1 - 0.067 12.9 13.8 0.12 12.0 13.8 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Fzo_mitofusin PF04799.11 001277415.1_23523001_1 - 0.098 12.0 4.4 0.19 11.1 4.4 1.4 1 0 0 1 1 1 0 fzo-like conserved region Exonuc_VII_L PF02601.13 001277415.1_23523001_1 - 0.12 11.8 1.9 0.18 11.2 1.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF342 PF03961.11 001277415.1_23523001_1 - 0.13 10.7 4.7 0.19 10.2 4.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Reo_sigmaC PF04582.10 001277415.1_23523001_1 - 0.15 11.3 0.8 0.23 10.7 0.8 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein IncA PF04156.12 001277415.1_23523001_1 - 0.15 11.7 7.1 0.23 11.1 7.1 1.3 1 0 0 1 1 1 0 IncA protein Spc7 PF08317.9 001277415.1_23523001_1 - 0.17 10.6 10.5 0.28 9.9 10.5 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3552 PF12072.6 001277415.1_23523001_1 - 0.23 10.7 10.1 0.37 10.0 10.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF3782 PF12644.5 001277415.1_23523001_1 - 0.36 10.9 4.8 6.2 6.9 0.0 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3782) DUF724 PF05266.12 001277415.1_23523001_1 - 0.61 9.7 9.5 1.1 8.9 9.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Spc24 PF08286.9 001277415.1_23523001_1 - 0.63 10.2 12.5 0.75 9.9 5.0 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 SlyX PF04102.10 001277415.1_23523001_1 - 0.69 10.5 15.5 0.15 12.5 3.8 3.7 3 1 1 4 4 4 0 SlyX FlaC_arch PF05377.9 001277415.1_23523001_1 - 0.81 10.0 11.3 1.2 9.4 0.7 2.6 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.10 001277415.1_23523001_1 - 0.84 9.5 4.7 1.5 8.7 4.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) TBPIP PF07106.11 001277415.1_23523001_1 - 1 9.0 11.6 0.13 11.8 7.5 1.6 2 0 0 2 2 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Spore_III_AB PF09548.8 001277415.1_23523001_1 - 1.7 8.6 5.1 2.8 7.9 5.1 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Wtap PF17098.3 001277415.1_23523001_1 - 2.4 8.0 10.1 0.24 11.2 3.3 2.4 1 1 1 2 2 2 0 WTAP/Mum2p family DivIC PF04977.13 001277415.1_23523001_1 - 2.9 7.6 13.3 2.5 7.8 2.1 2.6 1 1 1 2 2 2 0 Septum formation initiator zf-CpG_bind_C PF12269.6 001277415.1_23523001_1 - 3.4 7.2 5.2 6.9 6.2 5.2 1.5 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain DUF4140 PF13600.4 001277415.1_23523001_1 - 3.9 7.8 7.3 38 4.7 7.3 2.2 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Nsp1_C PF05064.11 001277415.1_23523001_1 - 4.7 6.9 9.9 1.1 9.0 5.2 2.3 2 1 0 2 2 2 0 Nsp1-like C-terminal region BRE1 PF08647.9 001277415.1_23523001_1 - 4.7 7.2 17.4 2.5 8.1 13.6 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase HrpB7 PF09486.8 001277415.1_23523001_1 - 8.1 6.7 10.7 0.89 9.8 6.1 1.7 2 0 0 2 2 1 0 Bacterial type III secretion protein (HrpB7) Bap31 PF05529.10 001277415.1_23523001_1 - 8.3 5.8 8.3 15 5.0 8.3 1.3 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like COE1_DBD PF16422.3 204752.2_23524001_1 - 1.1e-146 486.2 0.9 1.4e-146 485.8 0.9 1.1 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain COE1_HLH PF16423.3 204752.2_23524001_1 - 1.2e-36 124.0 3.0 5.6e-30 102.7 0.4 2.4 2 0 0 2 2 2 2 Transcription factor COE1 helix-loop-helix domain TIG PF01833.22 204752.2_23524001_1 - 5.1e-12 45.6 0.3 5.1e-12 45.6 0.3 2.3 2 0 0 2 2 2 1 IPT/TIG domain CHRD PF07452.10 204980.2_23527001_1 - 7.4e-43 145.5 0.9 6.7e-16 59.0 0.1 4.2 4 0 0 4 4 4 4 CHRD domain VWC PF00093.16 204980.2_23527001_1 - 4.6e-33 113.2 76.2 6.7e-09 35.8 9.9 4.4 4 0 0 4 4 4 4 von Willebrand factor type C domain LRR_8 PF13855.4 001199591.2_23523001_2 - 6.7e-22 76.9 20.2 9.6e-09 34.7 3.9 3.9 1 1 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 001199591.2_23523001_2 - 3.4e-17 62.1 24.6 2.6e-05 24.3 2.6 4.7 1 1 2 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001199591.2_23523001_2 - 5.7e-07 29.0 19.0 3.2 8.5 0.2 7.4 7 0 0 7 7 7 5 Leucine Rich Repeat LRR_6 PF13516.4 001199591.2_23523001_2 - 0.00013 21.6 24.7 6.2 7.0 0.4 7.2 7 0 0 7 7 7 5 Leucine Rich repeat UCH PF00443.27 001257318.1_23528001_1 - 2.6e-40 138.4 0.4 1.9e-34 119.2 0.1 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 001257318.1_23528001_1 - 9e-25 87.8 0.0 1.9e-24 86.7 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Secretogranin_V PF05281.9 001291758.1_23525001_1 - 2.1e-11 43.8 0.4 3.4e-09 36.5 0.1 2.1 1 1 1 2 2 2 2 Neuroendocrine protein 7B2 precursor (Secretogranin V) MOZART1 PF12554.6 001164350.1_23522001_2 - 5.1e-25 86.8 0.4 7.2e-25 86.4 0.4 1.2 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated Pkinase PF00069.23 001199807.2_23524001_1 - 2.5e-62 210.5 0.0 4.9e-62 209.6 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001199807.2_23524001_1 - 5.9e-23 81.3 0.2 3.8e-22 78.7 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.12 001199807.2_23524001_1 - 1.8e-06 27.3 0.2 3.2e-06 26.5 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001199807.2_23524001_1 - 9.7e-05 21.7 0.0 0.00019 20.7 0.0 1.6 1 1 0 1 1 1 1 Kinase-like RF-1 PF00472.18 001252088.1_23522001_2 - 4.9e-22 77.9 2.1 7.1e-22 77.4 2.1 1.2 1 0 0 1 1 1 1 RF-1 domain BLM10_mid PF16507.3 001006393.2_23529001_2 - 2e-119 399.5 3.2 1.6e-117 393.2 0.1 4.0 4 1 0 4 4 4 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.6 001006393.2_23529001_2 - 6.9e-37 125.1 0.1 6.8e-36 122.0 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) HEAT PF02985.20 001006393.2_23529001_2 - 3.1e-07 29.9 0.7 0.055 13.6 0.1 4.9 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.4 001006393.2_23529001_2 - 0.0054 17.0 0.1 0.64 10.3 0.0 4.1 3 1 0 3 3 3 1 HEAT repeats CLASP_N PF12348.6 001006393.2_23529001_2 - 0.033 13.6 0.5 0.21 11.0 0.1 2.6 2 0 0 2 2 2 0 CLASP N terminal Arm PF00514.21 001006393.2_23529001_2 - 1.3 9.0 3.8 14 5.7 0.1 3.8 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 001006393.2_23529001_2 - 3.1 8.2 4.8 37 4.8 0.0 4.6 4 0 0 4 4 4 0 HEAT-like repeat Meleagrin PF08189.9 001317341.1_23521001_1 - 6.4e-27 92.8 13.2 1.1e-26 92.0 13.2 1.4 1 0 0 1 1 1 1 Meleagrin/Cygnin family C1-set PF07654.13 001312902.1_23523001_1 - 6.7e-16 58.4 0.0 1.1e-15 57.7 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_II_beta PF00969.17 001312902.1_23523001_1 - 1e-05 25.5 0.0 1.4e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain Ig_3 PF13927.4 001312902.1_23523001_1 - 3.4e-05 24.2 0.1 5.3e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001312902.1_23523001_1 - 0.00025 21.2 0.0 0.00045 20.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001312902.1_23523001_1 - 0.015 15.3 0.1 0.029 14.4 0.1 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Trypan_PARP PF05887.9 001312902.1_23523001_1 - 7 6.6 12.0 11 5.9 12.0 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Keratin PF02422.14 001277933.1_23522001_3 - 2.3e-35 120.0 15.4 7.8e-35 118.3 15.4 1.9 1 1 0 1 1 1 1 Keratin Keratin_2_head PF16208.3 001277933.1_23522001_3 - 0.46 10.5 29.5 0.69 9.9 29.5 1.2 1 0 0 1 1 1 0 Keratin type II head TPR_19 PF14559.4 001198680.1_23523001_2 - 1.2e-09 38.4 10.1 2.5e-05 24.6 2.2 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.4 001198680.1_23523001_2 - 6.4e-09 35.8 9.5 0.0083 16.7 0.6 5.1 1 1 4 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.15 001198680.1_23523001_2 - 1e-08 34.5 13.4 0.00023 20.9 1.3 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.4 001198680.1_23523001_2 - 6.6e-06 26.6 3.5 1.5 9.4 0.2 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.26 001198680.1_23523001_2 - 2.7e-05 23.7 6.9 0.22 11.3 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 001198680.1_23523001_2 - 0.00052 19.9 12.6 0.033 14.3 0.3 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.4 001198680.1_23523001_2 - 0.013 15.9 5.5 9.1 7.0 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.4 001198680.1_23523001_2 - 0.046 14.1 9.2 0.12 12.7 0.6 3.0 1 1 2 3 3 3 0 Alkyl sulfatase dimerisation TPR_9 PF13371.4 001198680.1_23523001_2 - 0.06 13.4 2.2 2.3 8.3 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.4 001198680.1_23523001_2 - 0.07 13.1 2.3 15 5.7 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.4 001198680.1_23523001_2 - 0.12 12.6 2.1 0.9 9.8 0.2 2.7 1 1 1 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 001198680.1_23523001_2 - 0.41 10.7 10.3 1.4 9.0 4.0 3.4 1 1 3 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.4 001198680.1_23523001_2 - 0.92 9.5 4.5 16 5.5 0.1 3.5 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.4 001198680.1_23523001_2 - 1 9.7 5.8 2.8 8.4 0.1 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.4 001198680.1_23523001_2 - 2.7 8.2 10.6 4 7.7 1.3 3.7 2 1 0 3 3 3 0 Tetratricopeptide repeat Keratin PF02422.14 001277974.1_23522001_2 - 8.7e-41 137.4 8.6 1.5e-40 136.7 8.6 1.4 1 0 0 1 1 1 1 Keratin Tet_JBP PF12851.5 001277794.1_23529001_1 - 7.4e-137 456.0 3.9 7.4e-137 456.0 3.9 3.3 3 1 0 3 3 3 1 Oxygenase domain of the 2OGFeDO superfamily F5_F8_type_C PF00754.23 001277110.1_23526001_3 - 1e-60 203.3 3.5 2e-31 108.6 3.0 2.2 2 0 0 2 2 2 2 F5/8 type C domain EGF PF00008.25 001277110.1_23526001_3 - 9.1e-25 86.5 39.7 6.7e-09 35.7 7.4 3.8 3 0 0 3 3 3 3 EGF-like domain EGF_2 PF07974.11 001277110.1_23526001_3 - 6.8e-08 32.6 47.9 0.00047 20.3 8.9 4.2 4 0 0 4 4 4 3 EGF-like domain hEGF PF12661.5 001277110.1_23526001_3 - 6.2e-06 26.5 46.5 0.00034 21.0 5.8 4.6 5 0 0 5 5 5 3 Human growth factor-like EGF RWD PF05773.20 001031075.2_23523001_2 - 1.7e-26 92.7 2.0 4e-26 91.4 2.0 1.7 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.3 001031075.2_23523001_2 - 2.8e-06 27.6 8.8 2.8e-06 27.6 8.8 3.0 2 1 1 3 3 3 1 DRG Family Regulatory Proteins, Tma46 DUF445 PF04286.10 001031075.2_23523001_2 - 0.012 15.3 6.9 0.015 15.0 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Folliculin PF11704.6 001031075.2_23523001_2 - 0.15 11.7 1.6 0.26 11.0 1.6 1.4 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport BUD22 PF09073.8 001031075.2_23523001_2 - 0.42 9.8 11.7 0.51 9.5 11.7 1.1 1 0 0 1 1 1 0 BUD22 Ank_4 PF13637.4 001199314.1_23525001_1 - 7.3e-52 173.0 25.2 3.5e-11 43.3 0.1 6.4 3 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank_2 PF12796.5 001199314.1_23525001_1 - 5.7e-50 167.7 9.8 5e-12 46.1 0.2 4.9 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.4 001199314.1_23525001_1 - 4.2e-39 128.0 13.0 0.00025 21.1 0.0 10.1 10 0 0 10 10 10 9 Ankyrin repeat Ank PF00023.28 001199314.1_23525001_1 - 9.6e-37 123.7 16.9 3.9e-06 26.9 0.0 9.5 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.4 001199314.1_23525001_1 - 1.7e-35 120.3 19.8 1.5e-07 31.4 0.1 8.4 2 1 7 9 9 9 8 Ankyrin repeats (many copies) NAPRTase PF04095.14 206981.2_23525001_1 - 0.01 15.3 0.0 0.47 9.9 0.0 2.4 2 1 0 2 2 2 0 Nicotinate phosphoribosyltransferase (NAPRTase) family UCH PF00443.27 204840.3_23529001_1 - 4.4e-85 285.1 0.1 6e-85 284.7 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_3 PF14836.4 204840.3_23529001_1 - 1.9e-38 130.1 0.1 3.6e-38 129.2 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain DUSP PF06337.10 204840.3_23529001_1 - 1.2e-21 77.0 1.3 1.2e-21 77.0 1.3 2.1 2 0 0 2 2 2 1 DUSP domain UCH_1 PF13423.4 204840.3_23529001_1 - 3.9e-18 66.0 0.0 2.6e-10 40.3 0.0 2.6 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.4 204840.3_23529001_1 - 3.8e-08 33.2 1.0 3.6e-07 30.0 0.0 2.6 3 0 0 3 3 3 1 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.6 204840.3_23529001_1 - 0.002 17.5 0.0 0.0042 16.4 0.0 1.4 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 CW_binding_1 PF01473.18 204840.3_23529001_1 - 0.67 10.3 8.0 0.5 10.7 4.7 2.6 2 0 0 2 2 2 0 Putative cell wall binding repeat CM_2 PF01817.19 204840.3_23529001_2 - 0.033 14.4 0.4 0.062 13.5 0.4 1.4 1 0 0 1 1 1 0 Chorismate mutase type II Snf7 PF03357.19 001199475.1_23524001_3 - 1.4e-51 174.4 20.4 1.9e-51 173.9 20.4 1.2 1 0 0 1 1 1 1 Snf7 SYF2 PF08231.10 001199475.1_23524001_3 - 0.026 14.8 9.7 0.047 14.0 9.7 1.4 1 0 0 1 1 1 0 SYF2 splicing factor Kinesin PF00225.21 001199426.1_23528001_1 - 4.8e-113 377.3 0.3 4.8e-113 377.3 0.3 2.2 2 1 1 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.3 001199426.1_23528001_1 - 2.4e-24 85.9 0.2 7e-24 84.4 0.2 1.8 1 0 0 1 1 1 1 Microtubule binding 14-3-3 PF00244.18 001293176.1_23522001_1 - 4.9e-102 340.0 4.0 5.6e-102 339.8 4.0 1.0 1 0 0 1 1 1 1 14-3-3 protein Peptidase_C98 PF15499.4 001293176.1_23522001_1 - 0.0063 15.9 0.1 0.01 15.2 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase DUF837 PF05769.9 001293176.1_23522001_1 - 0.047 13.5 0.3 0.047 13.5 0.3 2.4 4 0 0 4 4 4 0 Protein of unknown function (DUF837) Virulence_fact PF13769.4 001293176.1_23522001_1 - 0.31 11.1 3.9 0.37 10.8 0.3 2.7 3 0 0 3 3 3 0 Virulence factor PX PF00787.22 001101649.1_23523001_3 - 1.4e-14 53.9 2.2 2.6e-14 53.0 1.7 1.6 1 1 1 2 2 2 1 PX domain Homeobox PF00046.27 001199548.1_23523001_1 - 5.1e-21 74.1 1.0 8.2e-21 73.5 1.0 1.3 1 0 0 1 1 1 1 Homeobox domain TPR_2 PF07719.15 001040228.2_23527001_3 - 0.00054 19.7 5.0 0.26 11.4 0.3 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.4 001040228.2_23527001_3 - 0.021 14.4 1.3 0.75 9.4 0.2 2.8 2 0 0 2 2 2 0 TPR repeat TPR_7 PF13176.4 001040228.2_23527001_3 - 0.051 13.5 1.4 3.3 7.8 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.26 001040228.2_23527001_3 - 0.37 10.5 9.8 2.8 7.8 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat BC10 PF06726.10 001302141.1_23524001_2 - 1.5e-25 89.0 10.2 2.8e-25 88.2 10.2 1.5 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 Ank_2 PF12796.5 001204097.1_23529001_1 - 2.5e-150 489.3 37.9 1.7e-19 70.1 1.1 12.4 3 3 9 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001204097.1_23529001_1 - 2.6e-121 394.4 17.5 4.4e-10 39.8 0.0 16.3 8 3 7 17 17 17 16 Ankyrin repeats (many copies) Ank PF00023.28 001204097.1_23529001_1 - 1.1e-114 370.2 51.4 4.9e-08 33.0 0.0 24.7 24 0 0 24 24 24 23 Ankyrin repeat Ank_3 PF13606.4 001204097.1_23529001_1 - 1.2e-105 332.5 31.5 6.1e-05 23.0 0.0 25.5 25 0 0 25 25 25 23 Ankyrin repeat Ank_5 PF13857.4 001204097.1_23529001_1 - 6.7e-100 325.3 50.5 6.4e-09 35.8 0.0 21.1 6 4 15 22 22 22 21 Ankyrin repeats (many copies) KH_1 PF00013.27 001204097.1_23529001_1 - 1.2e-14 53.7 0.7 3.3e-14 52.3 0.7 1.8 1 0 0 1 1 1 1 KH domain Gb3_synth PF04572.10 001291811.1_23529001_1 - 4e-47 159.6 2.3 1e-46 158.2 0.9 2.1 2 0 0 2 2 2 1 Alpha 1,4-glycosyltransferase conserved region Gly_transf_sug PF04488.13 001291811.1_23529001_1 - 1e-21 77.3 0.0 2.1e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.5 001291811.1_23529001_1 - 0.24 10.5 0.0 0.36 9.9 0.0 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Keratin PF02422.14 001277973.1_23522001_1 - 9.8e-41 137.2 8.6 1.5e-40 136.7 8.6 1.3 1 0 0 1 1 1 1 Keratin Hydrolase_4 PF12146.6 001277142.1_23528001_1 - 6.9e-73 244.7 0.1 1e-72 244.2 0.1 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 001277142.1_23528001_1 - 2.9e-10 40.1 0.2 1.9e-07 30.9 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001277142.1_23528001_1 - 2.6e-09 37.9 0.0 5.1e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.18 001277142.1_23528001_1 - 0.00013 21.6 0.0 0.00023 20.8 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.19 001277142.1_23528001_1 - 0.0011 18.3 0.1 0.24 10.7 0.0 3.0 3 0 0 3 3 3 1 Prolyl oligopeptidase family Lipase_3 PF01764.23 001277142.1_23528001_1 - 0.0016 18.2 0.0 0.0031 17.3 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) DLH PF01738.16 001277142.1_23528001_1 - 0.002 17.6 0.0 0.047 13.1 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.14 001277142.1_23528001_1 - 0.01 15.5 0.1 2.9 7.5 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase PGAP1 PF07819.11 001277142.1_23528001_1 - 0.017 14.7 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Thioesterase PF00975.18 001277142.1_23528001_1 - 0.026 14.5 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 Thioesterase domain Tetraspannin PF00335.18 001257258.1_23523001_1 - 3.5e-41 141.2 10.7 4.6e-41 140.8 10.7 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF843 PF05814.9 001257258.1_23523001_1 - 0.13 12.2 3.0 6 6.8 0.0 2.7 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) ECSCR PF15820.3 001257258.1_23523001_1 - 2.7 7.7 4.7 1.5 8.5 2.3 1.8 1 1 1 2 2 2 0 Endothelial cell-specific chemotaxis regulator SUR7 PF06687.10 001257258.1_23523001_1 - 5.7 6.4 13.1 0.087 12.3 3.1 2.5 3 0 0 3 3 3 0 SUR7/PalI family Thyroglobulin_1 PF00086.16 001277676.1_23522001_2 - 6.5e-09 35.2 3.2 6.5e-09 35.2 3.2 2.4 1 1 2 3 3 3 1 Thyroglobulin type-1 repeat Calcipressin PF04847.10 001278079.1_23527001_2 - 6e-58 195.5 0.5 8.2e-58 195.1 0.5 1.1 1 0 0 1 1 1 1 Calcipressin Fucokinase PF07959.10 001204815.1_23526001_1 - 2.6e-143 477.8 0.4 3.1e-143 477.5 0.4 1.1 1 0 0 1 1 1 1 L-fucokinase Hexapep PF00132.22 001204815.1_23526001_1 - 0.0014 18.2 0.7 0.0043 16.6 0.7 1.8 1 0 0 1 1 1 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.4 001204815.1_23526001_1 - 0.28 10.8 2.8 0.57 9.8 2.1 1.9 1 1 1 2 2 2 0 Hexapeptide repeat of succinyl-transferase Anoctamin PF04547.10 001199465.1_23527001_2 - 4e-162 539.8 16.2 5e-162 539.5 16.2 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.3 001199465.1_23527001_2 - 9.6e-76 254.3 2.0 1.7e-75 253.5 2.0 1.4 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Keratin PF02422.14 001277963.1_23522001_1 - 8.2e-41 137.5 11.7 1.2e-40 136.9 11.7 1.3 1 0 0 1 1 1 1 Keratin CALCOCO1 PF07888.9 001277963.1_23522001_1 - 0.11 10.9 0.2 0.14 10.5 0.2 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Adaptin_binding PF10199.7 001271528.1_23523001_2 - 1.6e-18 67.4 1.8 2.2e-18 66.9 1.8 1.2 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 MARVEL PF01284.21 001199391.1_23522001_2 - 4e-13 49.5 18.3 6.4e-13 48.8 18.3 1.4 1 0 0 1 1 1 1 Membrane-associating domain EGF PF00008.25 001252033.1_23529001_2 - 1.9e-209 676.9 541.0 3.3e-09 36.7 6.7 36.4 36 0 0 36 36 35 35 EGF-like domain hEGF PF12661.5 001252033.1_23529001_2 - 1.9e-134 434.2 469.9 1.1e-06 29.0 3.5 37.4 36 0 0 36 36 34 33 Human growth factor-like EGF EGF_CA PF07645.13 001252033.1_23529001_2 - 7.7e-60 198.7 532.8 5.3e-09 36.0 6.0 36.9 19 11 17 36 36 32 21 Calcium-binding EGF domain Ank_2 PF12796.5 001252033.1_23529001_2 - 8e-28 96.7 19.4 8.2e-12 45.4 1.5 4.2 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) DUF3454 PF11936.6 001252033.1_23529001_2 - 5.3e-25 87.5 20.9 2.8e-24 85.2 20.9 2.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3454) Ank PF00023.28 001252033.1_23529001_2 - 1.2e-24 85.4 10.2 8e-06 25.9 0.0 7.0 6 0 0 6 6 6 6 Ankyrin repeat NOD PF06816.11 001252033.1_23529001_2 - 8e-24 82.9 0.0 1.3e-23 82.2 0.0 1.4 1 0 0 1 1 1 1 NOTCH protein Notch PF00066.15 001252033.1_23529001_2 - 1.6e-23 82.7 56.0 1e-11 44.9 15.0 13.8 14 2 3 17 17 3 3 LNR domain EGF_2 PF07974.11 001252033.1_23529001_2 - 2.6e-23 81.9 645.7 0.00078 19.6 12.5 38.6 37 2 2 39 39 36 25 EGF-like domain Ank_5 PF13857.4 001252033.1_23529001_2 - 5.9e-22 77.3 13.7 8.2e-09 35.5 1.5 5.5 3 2 2 5 5 5 4 Ankyrin repeats (many copies) NODP PF07684.10 001252033.1_23529001_2 - 1.3e-18 66.7 0.0 1.3e-18 66.7 0.0 4.1 3 0 0 3 3 1 1 NOTCH protein Ank_4 PF13637.4 001252033.1_23529001_2 - 1.1e-15 57.6 2.7 3.1e-05 24.3 0.2 5.0 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 001252033.1_23529001_2 - 7.8e-15 53.4 3.9 0.062 13.7 0.0 7.0 6 0 0 6 6 6 3 Ankyrin repeat EGF_3 PF12947.5 001252033.1_23529001_2 - 3.1e-06 27.1 15.0 0.0001 22.3 3.2 36.8 33 3 3 36 36 32 13 EGF domain cEGF PF12662.5 001252033.1_23529001_2 - 0.011 15.5 0.6 0.011 15.5 0.6 35.1 33 2 0 33 33 30 0 Complement Clr-like EGF-like ANAPC4_WD40 PF12894.5 001006299.2_23524001_1 - 1.5e-13 50.7 0.1 0.0016 18.6 0.0 6.9 3 2 4 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 001006299.2_23524001_1 - 3.3e-10 40.2 5.9 0.0091 16.7 0.0 8.4 8 1 1 9 9 9 1 WD domain, G-beta repeat eIF2A PF08662.9 001006299.2_23524001_1 - 7.4e-08 32.4 0.1 0.091 12.5 0.0 3.7 2 1 0 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.10 001006299.2_23524001_1 - 0.0064 16.3 0.5 55 3.7 0.0 4.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat IKI3 PF04762.10 001006299.2_23524001_1 - 0.098 10.5 3.6 6.9 4.4 0.0 3.2 2 2 3 5 5 5 0 IKI3 family zf-C2H2 PF00096.24 001170344.1_23523001_1 - 2.4e-12 46.4 25.2 0.0002 21.5 4.5 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001170344.1_23523001_1 - 4.8e-11 42.4 20.5 4e-06 26.9 0.7 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001170344.1_23523001_1 - 2.9e-08 33.7 22.0 0.0078 16.8 2.3 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001170344.1_23523001_1 - 9.5e-05 22.1 1.3 9.5e-05 22.1 1.3 3.5 4 0 0 4 4 3 3 C2H2-type zinc finger zf-AN1 PF01428.14 001170344.1_23523001_1 - 0.001 19.0 10.6 0.051 13.6 1.1 3.4 3 0 0 3 3 3 1 AN1-like Zinc finger zf-C2H2_jaz PF12171.6 001170344.1_23523001_1 - 0.0029 17.7 14.6 0.1 12.8 1.4 3.3 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 001170344.1_23523001_1 - 0.007 16.3 7.2 0.061 13.3 1.4 2.5 2 0 0 2 2 2 1 Zinc ribbon domain C1_4 PF07975.10 001170344.1_23523001_1 - 0.016 15.3 11.5 0.55 10.4 5.8 2.6 1 1 0 2 2 2 0 TFIIH C1-like domain zf-met PF12874.5 001170344.1_23523001_1 - 0.036 14.3 0.9 0.036 14.3 0.9 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type XPA_N PF01286.16 001170344.1_23523001_1 - 0.04 13.8 8.0 0.49 10.3 0.8 3.3 3 0 0 3 3 3 0 XPA protein N-terminal GAGA PF09237.9 001170344.1_23523001_1 - 0.063 13.0 2.3 0.23 11.2 0.5 2.4 1 1 1 2 2 2 0 GAGA factor DUF4379 PF14311.4 001170344.1_23523001_1 - 0.85 9.9 3.0 0.9 9.8 0.2 2.1 2 0 0 2 2 2 0 Probable Zinc-ribbon domain CpXC PF14353.4 001170344.1_23523001_1 - 1.2 9.1 6.2 1 9.3 0.1 2.6 1 1 2 3 3 3 0 CpXC protein FYVE PF01363.19 001170344.1_23523001_1 - 3 7.9 13.9 0.45 10.6 5.6 2.4 1 1 1 2 2 2 0 FYVE zinc finger LIM PF00412.20 001170344.1_23523001_1 - 6.7 6.9 12.3 20 5.3 0.2 2.7 1 1 0 2 2 2 0 LIM domain zf-Di19 PF05605.10 001170344.1_23523001_1 - 9.6 6.4 10.2 0.41 10.8 3.5 2.0 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding GAF_2 PF13185.4 001170344.1_23523001_3 - 3.1 8.0 6.0 14 5.9 0.2 2.7 2 0 0 2 2 2 0 GAF domain Kinesin PF00225.21 001293305.1_23529001_1 - 3.3e-111 371.3 0.1 9.4e-111 369.8 0.1 1.8 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 001293305.1_23529001_1 - 2e-25 89.4 2.7 3e-25 88.8 0.0 2.6 2 0 0 2 2 2 1 Microtubule binding DASH_Dam1 PF08653.8 001293305.1_23529001_1 - 5.4 6.8 12.2 9.6 6.0 0.6 3.9 3 0 0 3 3 3 0 DASH complex subunit Dam1 M-inducer_phosp PF06617.11 001199572.1_23525001_3 - 6.8e-76 255.0 11.5 1.3e-75 254.1 11.5 1.4 1 0 0 1 1 1 1 M-phase inducer phosphatase Rhodanese PF00581.18 001199572.1_23525001_3 - 4e-12 46.5 0.0 1e-11 45.2 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain LRR19-TM PF15176.4 001199572.1_23525001_3 - 0.17 11.8 0.5 8.2 6.3 0.1 3.0 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain Romo1 PF10247.7 001198821.1_23522001_3 - 8.3e-25 86.8 21.0 1.3e-24 86.2 21.0 1.3 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.17 001198821.1_23522001_3 - 0.011 15.9 8.6 0.017 15.3 8.6 1.3 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family RhoGAP PF00620.25 001244882.1_23529001_3 - 3.1e-50 169.8 0.2 8.8e-50 168.3 0.2 1.8 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.20 001244882.1_23529001_3 - 1.5e-06 27.8 9.9 3.9e-06 26.5 9.9 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) HDV_ag PF01517.16 001244882.1_23529001_3 - 0.44 10.2 2.3 1.4 8.5 2.3 1.9 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen CTD_bind PF04818.11 001006341.2_23527001_3 - 3.5e-18 66.1 1.4 8.7e-18 64.8 0.6 2.2 2 0 0 2 2 2 1 RNA polymerase II-binding domain. Surp PF01805.18 001006341.2_23527001_3 - 4.4e-17 61.7 0.4 1.3e-16 60.2 0.4 1.8 1 0 0 1 1 1 1 Surp module G-patch PF01585.21 001006341.2_23527001_3 - 2.3e-11 43.3 4.7 4.9e-11 42.2 4.7 1.6 1 0 0 1 1 1 1 G-patch domain Apt1 PF10351.7 001006341.2_23527001_3 - 0.2 10.3 13.6 0.33 9.6 13.6 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.15 001006341.2_23527001_3 - 3.6 6.1 9.4 7.8 5.0 9.4 1.4 1 0 0 1 1 1 0 Presenilin DUF1489 PF07370.9 001252276.2_23526001_2 - 0.18 11.4 0.3 0.34 10.5 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1489) LRR_8 PF13855.4 001252276.2_23526001_3 - 1.5e-105 344.8 69.4 9.2e-16 57.2 0.3 10.3 4 2 7 12 12 12 12 Leucine rich repeat LRR_4 PF12799.5 001252276.2_23526001_3 - 1.9e-41 139.1 36.7 1.6e-05 25.0 0.3 12.7 6 2 5 14 14 14 12 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001252276.2_23526001_3 - 1.5e-23 83.1 0.0 3.9e-05 23.5 0.0 4.3 2 2 2 4 4 4 4 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001252276.2_23526001_3 - 6.5e-20 71.2 8.9 1.5e-05 24.4 0.0 6.5 2 2 5 7 7 7 5 Leucine-rich repeat LRR_1 PF00560.31 001252276.2_23526001_3 - 7.4e-13 46.9 39.2 1.2 9.7 0.0 17.6 20 2 0 20 20 20 5 Leucine Rich Repeat LRRNT PF01462.16 001252276.2_23526001_3 - 1.8e-08 33.7 17.7 0.00059 19.3 4.2 3.3 2 0 0 2 2 2 2 Leucine rich repeat N-terminal domain LRR_6 PF13516.4 001252276.2_23526001_3 - 0.00017 21.2 41.8 3 8.0 0.0 15.6 19 0 0 19 19 19 2 Leucine Rich repeat LRRCT PF01463.22 001252276.2_23526001_3 - 0.00021 21.4 6.2 0.032 14.7 0.7 4.4 4 0 0 4 4 4 2 Leucine rich repeat C-terminal domain zf-RING_2 PF13639.4 001195570.3_23529001_1 - 1.4e-06 28.3 9.2 1.4e-06 28.3 9.2 3.2 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.4 001195570.3_23529001_1 - 0.00011 21.9 4.4 0.00011 21.9 4.4 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001195570.3_23529001_1 - 0.00012 21.7 9.4 0.00012 21.7 9.4 3.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001195570.3_23529001_1 - 0.00016 21.8 9.4 0.0011 19.1 9.4 2.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 001195570.3_23529001_1 - 0.00035 20.4 9.4 0.00035 20.4 9.4 3.3 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001195570.3_23529001_1 - 0.00043 20.0 10.3 0.00043 20.0 10.3 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 001195570.3_23529001_1 - 0.0018 18.2 5.2 0.0051 16.7 5.2 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.4 001195570.3_23529001_1 - 1.1 9.3 15.2 0.13 12.3 9.8 2.4 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.3 001195570.3_23529001_1 - 4.7 6.9 9.0 13 5.4 9.0 1.9 1 0 0 1 1 1 0 RING-like zinc finger UPF0565 PF10561.7 001039306.2_23528001_3 - 7.7e-113 376.5 0.0 9.7e-113 376.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0565 CH PF00307.29 001159347.2_23529001_2 - 1.2e-14 54.3 0.6 2.3e-14 53.3 0.1 1.8 2 0 0 2 2 1 1 Calponin homology (CH) domain AAA_14 PF13173.4 001159347.2_23529001_2 - 2.4e-05 24.2 0.0 6.3e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.27 001159347.2_23529001_2 - 3e-05 24.3 0.0 8.9e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 001159347.2_23529001_2 - 5.4e-05 23.3 0.2 0.0018 18.4 0.2 2.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 001159347.2_23529001_2 - 0.00013 22.2 0.2 0.045 14.0 0.0 2.8 1 1 1 2 2 2 1 AAA ATPase domain CAMSAP_CH PF11971.6 001159347.2_23529001_2 - 0.0014 18.2 0.2 0.011 15.4 0.0 2.3 2 0 0 2 2 2 1 CAMSAP CH domain RNA_helicase PF00910.20 001159347.2_23529001_2 - 0.0021 18.3 0.0 0.0077 16.5 0.0 2.0 1 0 0 1 1 1 1 RNA helicase PhoH PF02562.14 001159347.2_23529001_2 - 0.0041 16.5 0.0 0.0083 15.5 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein AAA_18 PF13238.4 001159347.2_23529001_2 - 0.0048 17.3 0.0 0.019 15.4 0.0 2.0 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.15 001159347.2_23529001_2 - 0.011 15.4 0.0 0.024 14.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.4 001159347.2_23529001_2 - 0.021 15.0 0.0 0.04 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.13 001159347.2_23529001_2 - 0.024 14.5 0.2 0.33 10.8 0.1 2.6 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit AAA_5 PF07728.12 001159347.2_23529001_2 - 0.027 14.3 0.0 0.068 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) T2SSE PF00437.18 001159347.2_23529001_2 - 0.028 13.4 0.0 0.054 12.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_24 PF13479.4 001159347.2_23529001_2 - 0.03 13.9 0.0 0.059 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.12 001159347.2_23529001_2 - 0.04 13.9 0.0 0.091 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_25 PF13481.4 001159347.2_23529001_2 - 0.051 13.0 0.0 0.16 11.4 0.0 1.7 1 1 1 2 2 2 0 AAA domain AAA_19 PF13245.4 001159347.2_23529001_2 - 0.059 13.6 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.19 001159347.2_23529001_2 - 0.082 12.1 0.0 0.18 11.0 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NACHT PF05729.10 001159347.2_23529001_2 - 0.082 12.7 0.0 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 NACHT domain DivIC PF04977.13 001159347.2_23529001_2 - 0.22 11.2 13.0 2.9 7.6 0.1 4.5 4 0 0 4 4 4 0 Septum formation initiator Perilipin PF03036.14 001317088.1_23524001_3 - 3.6e-160 533.2 17.4 1.3e-159 531.3 17.4 1.7 1 1 0 1 1 1 1 Perilipin family ISG65-75 PF11727.6 001317088.1_23524001_3 - 0.059 12.5 0.9 0.46 9.5 0.0 2.3 2 0 0 2 2 2 0 Invariant surface glycoprotein DUF1664 PF07889.10 001317088.1_23524001_3 - 0.078 12.8 4.8 0.36 10.7 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) VPS13_C PF16909.3 001317088.1_23524001_3 - 0.1 12.1 2.9 0.34 10.5 0.1 2.8 2 1 1 3 3 3 0 Vacuolar-sorting-associated 13 protein C-terminal DUF883 PF05957.11 001317088.1_23524001_3 - 0.13 12.8 6.4 5.5 7.5 0.0 3.8 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) Tape_meas_lam_C PF09718.8 001317088.1_23524001_3 - 0.13 12.3 1.0 0.96 9.5 0.6 2.6 2 1 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) Apolipoprotein PF01442.16 001317088.1_23524001_3 - 0.14 11.9 14.4 3.2 7.5 0.5 3.5 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain SseC PF04888.10 001317088.1_23524001_3 - 0.17 11.2 10.9 0.57 9.5 10.9 1.9 1 1 0 1 1 1 0 Secretion system effector C (SseC) like family DUF2505 PF10698.7 001317088.1_23524001_3 - 1 9.3 5.8 0.16 12.0 1.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2505) Baculo_PEP_C PF04513.10 001317088.1_23524001_3 - 2.9 7.8 7.5 35 4.3 0.2 3.5 2 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus KH_1 PF00013.27 001199507.1_23526001_3 - 3.2e-38 129.2 6.1 2.3e-15 56.0 0.4 5.8 6 0 0 6 6 6 3 KH domain SAM_1 PF00536.28 001199507.1_23526001_3 - 2.8e-14 53.2 0.1 5.8e-14 52.2 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 001199507.1_23526001_3 - 4.7e-11 42.5 0.1 1.2e-10 41.3 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) KH_2 PF07650.15 001199507.1_23526001_3 - 0.00035 20.2 0.1 0.13 12.0 0.2 2.7 2 0 0 2 2 2 2 KH domain IGR PF09597.8 001199507.1_23526001_3 - 0.1 12.6 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 IGR protein motif Sec5 PF15469.4 001006376.2_23528001_2 - 8.4e-56 188.6 0.8 2.9e-55 186.8 0.0 2.3 2 0 0 2 2 2 1 Exocyst complex component Sec5 TIG PF01833.22 001006376.2_23528001_2 - 2.4e-08 33.8 0.6 4.6e-08 32.9 0.6 1.5 1 0 0 1 1 1 1 IPT/TIG domain SAM_2 PF07647.15 001006376.2_23528001_2 - 0.034 14.1 0.1 0.14 12.2 0.1 2.1 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Keratin PF02422.14 001277935.1_23522001_2 - 7.6e-38 128.0 13.7 7.6e-38 128.0 13.7 2.1 1 1 1 2 2 2 1 Keratin Amino_oxidase PF01593.22 001099351.3_23524001_1 - 2.8e-74 250.9 0.0 3.3e-74 250.7 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 001099351.3_23524001_1 - 1.7e-16 60.1 0.0 4.5e-16 58.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.19 001099351.3_23524001_1 - 1e-06 28.1 0.0 5.5e-06 25.7 0.0 2.0 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.25 001099351.3_23524001_1 - 1.3e-05 25.5 0.3 3.6e-05 24.1 0.3 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.12 001099351.3_23524001_1 - 1.4e-05 24.4 0.0 2.4e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 001099351.3_23524001_1 - 1.5e-05 24.7 0.1 0.0002 21.0 0.0 2.4 2 1 1 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.15 001099351.3_23524001_1 - 1.8e-05 24.0 0.1 3.2e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.5 001099351.3_23524001_1 - 0.00013 21.3 0.0 0.00019 20.8 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 001099351.3_23524001_1 - 0.00013 21.0 0.9 0.00024 20.2 0.9 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.17 001099351.3_23524001_1 - 0.00014 21.2 0.3 0.00025 20.3 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.12 001099351.3_23524001_1 - 0.00018 20.2 0.2 0.00028 19.6 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.4 001099351.3_23524001_1 - 0.01 15.0 0.0 0.02 14.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.9 001099351.3_23524001_1 - 0.015 14.0 0.0 0.022 13.4 0.0 1.1 1 0 0 1 1 1 0 MCRA family Trp_halogenase PF04820.12 001099351.3_23524001_1 - 0.031 13.0 0.4 0.043 12.5 0.4 1.2 1 0 0 1 1 1 0 Tryptophan halogenase 3HCDH_N PF02737.16 001099351.3_23524001_1 - 0.031 14.0 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.20 001099351.3_23524001_1 - 0.039 12.9 0.0 0.086 11.8 0.0 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A DUF1188 PF06690.9 001099351.3_23524001_1 - 0.039 13.3 0.0 0.066 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) FMO-like PF00743.17 001099351.3_23524001_1 - 0.065 11.5 0.2 0.22 9.8 0.0 1.9 2 1 0 2 2 2 0 Flavin-binding monooxygenase-like NAD_Gly3P_dh_N PF01210.21 001099351.3_23524001_1 - 0.1 12.4 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.16 001099351.3_23524001_1 - 0.11 12.6 0.1 0.25 11.5 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain ApbA PF02558.14 001099351.3_23524001_1 - 0.19 11.2 0.3 0.54 9.7 0.1 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA adh_short PF00106.23 001318843.1_23522001_2 - 3.9e-28 98.1 0.0 5.8e-28 97.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001318843.1_23522001_2 - 2.1e-19 69.9 0.0 3.2e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001318843.1_23522001_2 - 4.5e-08 33.1 0.0 6.9e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 KR domain Band_7_C PF16200.3 001318843.1_23522001_2 - 0.026 14.4 0.0 0.053 13.5 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of band_7 NAD_binding_10 PF13460.4 001318843.1_23522001_2 - 0.16 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Prefoldin_2 PF01920.18 102330.1_23522120_2 - 8.8e-16 57.7 8.2 1.3e-14 53.9 4.5 2.2 2 0 0 2 2 2 2 Prefoldin subunit Cid2 PF09774.7 102734.1_23522120_1 - 4.1e-15 56.4 10.1 1.8e-10 41.3 2.7 2.2 2 0 0 2 2 2 2 Caffeine-induced death protein 2 Herpes_BTRF1 PF04682.10 102734.1_23522120_1 - 0.055 12.7 0.1 0.081 12.1 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus BTRF1 protein conserved region GST_C_3 PF14497.4 102408.1_23522120_2 - 5.9e-05 23.1 0.0 9.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 102408.1_23522120_2 - 0.00089 19.3 0.0 0.0013 18.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 102408.1_23522120_2 - 0.051 13.4 0.0 0.084 12.7 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 102408.1_23522120_3 - 4.8e-17 62.0 0.0 8.6e-17 61.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.18 102408.1_23522120_3 - 4.3e-16 58.9 0.1 9.2e-16 57.8 0.0 1.5 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 102408.1_23522120_3 - 1.4e-13 50.9 0.0 2.4e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Tom37 PF10568.7 102408.1_23522120_3 - 0.025 14.6 0.0 0.042 13.9 0.0 1.3 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein FUN14 PF04930.13 075082.1_23526120_1 - 2.1e-10 40.7 0.1 3.2e-10 40.2 0.1 1.2 1 0 0 1 1 1 1 FUN14 family E2F_TDP PF02319.18 045197.1_23524120_2 - 1.3e-22 79.4 0.1 2.4e-22 78.6 0.1 1.4 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.17 045197.1_23524120_2 - 0.06 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB E2F_CC-MB PF16421.3 045197.1_23524120_3 - 1.8e-21 76.3 0.3 2.9e-21 75.6 0.3 1.3 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain Prefoldin_2 PF01920.18 102331.1_23522120_2 - 6.5e-15 54.9 4.5 9.6e-15 54.3 4.5 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.18 102332.1_23522120_2 - 5.7e-14 51.8 7.4 7.9e-14 51.4 7.4 1.1 1 0 0 1 1 1 1 Prefoldin subunit zf-C3HC4 PF00097.23 102328.1_23523120_3 - 2.5e-06 27.1 7.0 4.9e-06 26.2 7.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Torus PF16131.3 102328.1_23523120_3 - 0.00034 21.2 0.1 0.00064 20.3 0.1 1.4 1 0 0 1 1 1 1 Torus domain zf-RING_2 PF13639.4 102328.1_23523120_3 - 0.00035 20.6 8.8 0.00035 20.6 8.8 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 102328.1_23523120_3 - 0.001 18.8 6.2 0.0021 17.8 6.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 102328.1_23523120_3 - 0.0017 18.2 4.9 0.0067 16.3 5.0 2.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.5 102328.1_23523120_3 - 0.0018 18.4 5.7 0.0018 18.4 5.7 2.0 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-CCCH PF00642.22 102328.1_23523120_3 - 0.0023 17.7 2.3 0.0045 16.7 2.3 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_4 PF15227.4 102328.1_23523120_3 - 0.0051 16.8 1.6 0.0051 16.8 1.6 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.5 102328.1_23523120_3 - 0.012 15.5 1.1 0.029 14.3 1.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.3 102328.1_23523120_3 - 0.21 11.2 5.7 0.53 9.9 5.7 1.7 1 0 0 1 1 1 0 RING-like zinc finger Prok-RING_4 PF14447.4 102328.1_23523120_3 - 0.87 9.4 7.1 8.9 6.1 7.4 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.4 102328.1_23523120_3 - 2.7 7.8 10.6 22 4.9 10.6 2.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Xpo1 PF08389.10 133667.1_23525120_2 - 6.2e-19 68.4 0.1 9.4e-19 67.8 0.1 1.2 1 0 0 1 1 1 1 Exportin 1-like protein PX PF00787.22 001199488.2_23526001_3 - 1.2e-18 67.0 0.0 3.5e-18 65.5 0.0 1.7 1 0 0 1 1 1 1 PX domain DUF641 PF04859.10 001199488.2_23526001_3 - 0.011 15.9 1.4 0.029 14.6 1.1 1.7 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) IncA PF04156.12 001199488.2_23526001_3 - 0.92 9.1 6.3 1.5 8.4 6.3 1.2 1 0 0 1 1 1 0 IncA protein DCX PF03607.15 204335.3_23526001_3 - 1.6e-42 143.3 0.1 9e-22 76.8 0.0 2.4 2 0 0 2 2 2 2 Doublecortin DUF2457 PF10446.7 204335.3_23526001_3 - 0.14 11.1 4.8 0.26 10.3 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Synaptonemal_3 PF15191.4 001278131.2_23522001_2 - 6.3e-33 112.3 5.7 8.5e-33 111.9 5.7 1.2 1 0 0 1 1 1 1 Synaptonemal complex central element protein 3 HALZ PF02183.16 001278131.2_23522001_2 - 0.054 13.6 1.6 0.1 12.7 1.6 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper RRM_1 PF00076.20 001012768.3_23528001_3 - 7.5e-55 182.5 0.6 1.5e-18 66.3 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 001012768.3_23528001_3 - 1.9e-06 27.7 0.6 0.019 14.9 0.0 3.1 3 0 0 3 3 3 2 RNA binding motif Limkain-b1 PF11608.6 001012768.3_23528001_3 - 3.8e-05 23.6 0.1 0.033 14.1 0.0 2.6 2 0 0 2 2 2 2 Limkain b1 RRM_5 PF13893.4 001012768.3_23528001_3 - 0.00014 21.3 0.0 0.2 11.2 0.0 3.2 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001012768.3_23528001_3 - 0.015 15.0 0.0 1.4 8.7 0.0 2.3 2 0 0 2 2 2 0 Occluded RNA-recognition motif BRICHOS PF04089.12 001277418.2_23527001_3 - 3.8e-22 78.0 0.0 6.7e-22 77.2 0.0 1.4 1 0 0 1 1 1 1 BRICHOS domain Reprolysin PF01421.17 001142850.3_23529001_1 - 1.5e-73 246.8 0.0 3.5e-73 245.6 0.0 1.6 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 001142850.3_23529001_1 - 1.5e-32 112.3 4.2 1.5e-32 112.3 4.2 3.3 3 0 0 3 3 2 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 001142850.3_23529001_1 - 1.9e-29 102.6 0.1 3.7e-29 101.6 0.1 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 001142850.3_23529001_1 - 1e-20 74.6 0.0 2e-20 73.7 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.21 001142850.3_23529001_1 - 9.2e-20 71.1 27.9 9.2e-20 71.1 27.9 4.0 4 0 0 4 4 4 1 Disintegrin Reprolysin_3 PF13582.4 001142850.3_23529001_1 - 2.3e-14 53.8 0.0 4.4e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001142850.3_23529001_1 - 5.1e-14 52.3 0.0 7.7e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 001142850.3_23529001_1 - 4.3e-13 49.5 0.0 7.2e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like FAM165 PF14981.4 001142850.3_23529001_1 - 0.09 12.5 0.1 0.21 11.3 0.1 1.6 1 0 0 1 1 1 0 FAM165 family Peptidase_M66 PF10462.7 001142850.3_23529001_1 - 0.1 11.4 0.2 0.16 10.8 0.2 1.2 1 0 0 1 1 1 0 Peptidase M66 Zincin_1 PF06262.9 001142850.3_23529001_1 - 0.15 12.0 0.1 0.3 11.1 0.1 1.4 1 0 0 1 1 1 0 Zinicin-like metallopeptidase T-box PF00907.20 204453.3_23527001_1 - 7.8e-80 267.3 0.0 1.6e-79 266.3 0.0 1.5 2 0 0 2 2 2 1 T-box Synaptonemal_3 PF15191.4 001278130.2_23522001_2 - 8.4e-33 111.9 5.7 1.1e-32 111.4 5.7 1.2 1 0 0 1 1 1 1 Synaptonemal complex central element protein 3 HALZ PF02183.16 001278130.2_23522001_2 - 0.066 13.3 1.6 0.13 12.4 1.6 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper Synaptonemal_3 PF15191.4 001278129.2_23522001_1 - 9.7e-33 111.7 5.7 1.4e-32 111.2 5.7 1.2 1 0 0 1 1 1 1 Synaptonemal complex central element protein 3 HALZ PF02183.16 001278129.2_23522001_1 - 0.075 13.1 1.6 0.15 12.2 1.6 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper Med30 PF11315.6 001277438.1_23522001_3 - 4.5e-66 221.5 1.3 5.5e-66 221.2 1.3 1.1 1 0 0 1 1 1 1 Mediator complex subunit 30 Sigma70_ner PF04546.11 001277438.1_23522001_3 - 0.048 13.4 1.3 0.1 12.3 1.3 1.5 1 1 0 1 1 1 0 Sigma-70, non-essential region UBX PF00789.18 001278045.2_23525001_1 - 1.9e-08 34.2 0.0 3.4e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 UBX domain BTB PF00651.29 001277639.2_23528001_2 - 1.6e-17 63.6 0.1 3.4e-17 62.5 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 001277639.2_23528001_2 - 1.9e-16 59.4 36.7 3.4e-05 23.9 2.6 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001277639.2_23528001_2 - 1.6e-14 53.5 19.4 8.9e-07 29.0 0.7 5.5 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 001277639.2_23528001_2 - 2e-11 43.5 34.0 0.00046 20.6 2.6 5.0 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_5 PF13909.4 001277639.2_23528001_2 - 0.0083 15.7 2.4 0.0083 15.7 2.4 3.8 4 0 0 4 4 3 2 C2H2-type zinc-finger domain DUF899 PF05988.10 001277639.2_23528001_2 - 0.013 14.9 0.1 0.013 14.9 0.1 1.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF899) zf-C2H2_11 PF16622.3 001277639.2_23528001_2 - 0.017 14.7 23.9 0.015 14.9 2.3 4.2 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.5 001277639.2_23528001_2 - 0.25 11.6 23.7 0.85 9.9 0.7 4.8 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.5 001277639.2_23528001_2 - 0.64 10.3 24.5 0.073 13.4 1.6 4.3 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-Dof PF02701.13 001277639.2_23528001_2 - 1.4 8.9 4.8 0.3 11.1 0.9 1.9 1 1 0 1 1 1 0 Dof domain, zinc finger zf-C2H2_6 PF13912.4 001277639.2_23528001_2 - 2 8.3 24.6 1.3 8.9 0.9 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger AHH PF14412.4 001277639.2_23528001_2 - 3.6 7.6 5.9 1.5e+02 2.3 5.9 2.5 1 1 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH COMM_domain PF07258.12 102412.2_23522120_2 - 2.2e-16 59.6 0.0 4.2e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 COMM domain Troponin-I_N PF11636.6 102412.2_23522120_3 - 0.00081 19.1 1.2 0.00081 19.1 1.2 3.2 3 0 0 3 3 3 1 Troponin I residues 1-32 AA_permease PF00324.19 001006371.3_23529001_3 - 1.6e-62 211.5 30.7 4.4e-39 134.2 6.9 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.13 001006371.3_23529001_3 - 5.1e-47 160.7 9.4 1.7e-17 63.4 3.9 3.2 2 1 1 3 3 3 3 Solute carrier family 12 RNA_pol_Rpb4 PF03874.14 001293295.1_23524001_3 - 2.6e-30 105.1 4.5 3.4e-30 104.8 4.5 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 Muted PF14942.4 001293295.1_23524001_3 - 0.015 15.4 1.8 0.017 15.3 0.1 1.8 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein GDA1_CD39 PF01150.15 001321564.1_23529001_2 - 2.7e-105 352.4 0.2 3.6e-105 351.9 0.2 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Pkinase_Tyr PF07714.15 001321556.1_23526001_3 - 8.4e-92 307.0 1.0 1.1e-91 306.6 1.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001321556.1_23526001_3 - 3.4e-47 160.9 0.2 5e-47 160.3 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001321556.1_23526001_3 - 5.2e-40 135.3 0.1 4.1e-21 74.7 0.0 2.6 2 0 0 2 2 2 2 SH2 domain RIO1 PF01163.20 001321556.1_23526001_3 - 0.0078 15.7 1.5 0.013 14.9 1.5 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.12 001321556.1_23526001_3 - 0.14 11.4 0.1 0.23 10.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RNA_pol_Rpb4 PF03874.14 001293292.1_23524001_1 - 2.4e-30 105.3 4.5 3.2e-30 104.9 4.5 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 Muted PF14942.4 001293292.1_23524001_1 - 0.015 15.5 2.0 0.016 15.4 0.1 1.8 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein Med31 PF05669.10 001321595.1_23522001_3 - 1.1e-39 134.2 11.2 1.6e-39 133.7 11.2 1.2 1 0 0 1 1 1 1 SOH1 zf-H2C2_2 PF13465.4 001104945.1_16123001_2 - 1.1e-43 145.7 51.2 3e-08 33.6 2.6 7.4 7 0 0 7 7 7 7 Zinc-finger double domain zf-C2H2 PF00096.24 001104945.1_16123001_2 - 1.1e-31 107.4 58.7 1.3e-05 25.3 1.6 6.9 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001104945.1_16123001_2 - 5.3e-23 79.6 50.8 0.0011 19.4 1.4 6.7 6 0 0 6 6 6 6 C2H2-type zinc finger zf-H2C2_5 PF13909.4 001104945.1_16123001_2 - 1.1e-15 56.9 64.0 0.00043 19.9 3.5 7.6 6 1 0 6 6 6 6 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.4 001104945.1_16123001_2 - 1.9e-10 40.3 39.6 0.012 15.5 0.3 6.6 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001104945.1_16123001_2 - 3.9e-09 36.0 37.8 0.01 15.5 7.7 6.7 6 0 0 6 6 6 5 zinc-finger C2H2-type zf-met PF12874.5 001104945.1_16123001_2 - 3.1e-06 27.2 46.5 0.03 14.6 0.7 6.6 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zf-C2HE PF16278.3 001104945.1_16123001_2 - 0.00011 22.5 45.6 0.012 16.0 2.1 6.2 1 1 5 6 6 6 4 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_9 PF16293.3 001104945.1_16123001_2 - 0.0017 18.0 12.6 0.11 12.2 0.1 4.3 2 1 3 5 5 5 2 C2H2 type zinc-finger (1 copy) zf-C2H2_jaz PF12171.6 001104945.1_16123001_2 - 0.0085 16.2 43.0 0.061 13.5 0.5 6.9 5 1 1 6 6 6 3 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 001104945.1_16123001_2 - 0.039 14.0 23.4 0.2 11.7 2.9 4.5 2 2 4 6 6 6 0 Zinc ribbon domain GAGA PF09237.9 001104945.1_16123001_2 - 0.13 12.0 2.2 6.6 6.5 1.2 2.8 2 0 0 2 2 2 0 GAGA factor zf-CHCC PF10276.7 001104945.1_16123001_2 - 1.2 9.1 0.0 1.2 9.1 0.0 4.7 6 0 0 6 6 6 0 Zinc-finger domain zf-H2C2_2 PF13465.4 001104945.1_16123001_3 - 0.0071 16.6 2.0 0.035 14.4 2.0 2.3 1 0 0 1 1 1 1 Zinc-finger double domain zf-C2H2 PF00096.24 001104945.1_16123001_3 - 0.11 12.8 7.4 8 7.0 4.1 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type efThoc1 PF11957.6 001321609.1_23525001_1 - 9.9e-147 489.4 8.6 1.5e-146 488.8 8.6 1.2 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Death PF00531.20 001321609.1_23525001_1 - 1.5e-17 63.3 0.8 8.8e-17 60.9 0.2 2.5 2 0 0 2 2 2 1 Death domain JmjN PF02375.15 001321609.1_23525001_1 - 4.5 7.2 4.8 2.2 8.2 0.1 2.6 2 0 0 2 2 2 0 jmjN domain UQ_con PF00179.24 001277419.2_23526001_2 - 7e-48 161.7 0.0 9.5e-48 161.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme SGT1 PF07093.9 001199524.1_23526001_1 - 5.6e-236 784.4 0.0 6.4e-236 784.2 0.0 1.0 1 0 0 1 1 1 1 SGT1 protein BSP_II PF05432.9 001199524.1_23526001_1 - 0.46 10.0 8.6 0.91 9.0 8.6 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) CCM2_C PF16545.3 001197144.1_23524001_2 - 2.9e-47 159.2 0.3 4.8e-47 158.5 0.3 1.3 1 0 0 1 1 1 1 Cerebral cavernous malformation protein, harmonin-homology PID PF00640.21 001197144.1_23524001_2 - 0.0052 16.7 0.0 0.017 15.0 0.0 1.8 1 1 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) DUF1722 PF08349.9 001197144.1_23524001_2 - 0.034 14.3 0.1 0.08 13.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) HMG_box PF00505.17 204484.2_23523001_3 - 1.1e-24 86.5 0.8 7.4e-24 83.8 1.4 2.0 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.8 204484.2_23523001_3 - 2.4e-07 31.1 0.1 5.5e-07 30.0 0.1 1.6 1 0 0 1 1 1 1 HMG-box domain SR-25 PF10500.7 204484.2_23523001_3 - 7.3 6.0 11.3 15 5.0 11.3 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sema PF01403.17 001199749.1_23527001_2 - 1.1e-81 274.6 0.0 2e-81 273.8 0.0 1.4 1 0 0 1 1 1 1 Sema domain Ig_2 PF13895.4 001199749.1_23527001_2 - 1.6e-06 28.2 1.9 6.4e-06 26.3 1.9 2.0 1 0 0 1 1 1 1 Immunoglobulin domain PSI PF01437.23 001199749.1_23527001_2 - 1.1e-05 25.8 5.8 6.3e-05 23.3 5.8 2.4 1 0 0 1 1 1 1 Plexin repeat Ig_3 PF13927.4 001199749.1_23527001_2 - 0.014 15.8 2.2 0.038 14.5 1.2 2.2 2 0 0 2 2 2 0 Immunoglobulin domain DNA_pol_A_exo1 PF01612.18 001282289.3_23529001_3 - 6.3e-31 107.3 0.0 1.1e-30 106.5 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease RQC PF09382.8 001282289.3_23529001_3 - 8.4e-18 64.1 0.0 2.3e-17 62.7 0.0 1.6 1 0 0 1 1 1 1 RQC domain DEAD PF00270.27 001282289.3_23529001_3 - 6e-17 61.8 0.0 9.5e-15 54.7 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001282289.3_23529001_3 - 8.1e-17 61.5 0.0 3.1e-16 59.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HTH_40 PF14493.4 001282289.3_23529001_3 - 8.7e-12 45.2 0.1 2e-11 44.1 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HRDC PF00570.21 001282289.3_23529001_3 - 2.2e-11 43.4 0.2 5.7e-11 42.1 0.2 1.8 1 0 0 1 1 1 1 HRDC domain RecQ_Zn_bind PF16124.3 001282289.3_23529001_3 - 5.6e-10 39.6 1.8 1.6e-09 38.2 1.8 1.9 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.13 001282289.3_23529001_3 - 0.00096 19.1 0.0 0.0036 17.2 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit RAB3GAP2_C PF14656.4 001163800.1_23529001_2 - 1e-235 783.5 20.6 1.6e-235 782.8 20.6 1.3 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit C-terminus RAB3GAP2_N PF14655.4 001163800.1_23529001_2 - 1.3e-165 551.5 0.0 1.8e-165 551.0 0.0 1.2 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Pep3_Vps18 PF05131.12 001199655.1_23527001_2 - 1.9e-43 147.7 0.2 3.2e-42 143.7 0.0 2.4 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.18 001199655.1_23527001_2 - 2.6e-12 46.7 17.5 1.9e-09 37.4 3.8 3.0 2 1 0 2 2 2 2 Region in Clathrin and VPS zf-C3HC4_2 PF13923.4 001199655.1_23527001_2 - 0.0016 18.1 1.3 0.0016 18.1 1.3 3.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.3 001199655.1_23527001_2 - 0.002 17.6 0.1 0.002 17.6 0.1 2.5 3 0 0 3 3 2 1 Zinc-ribbon, C4HC2 type Vps39_2 PF10367.7 001199655.1_23527001_2 - 0.0024 18.2 0.4 0.0024 18.2 0.4 2.4 2 0 0 2 2 1 1 Vacuolar sorting protein 39 domain 2 zf-RING_5 PF14634.4 001199655.1_23527001_2 - 0.0077 16.1 0.3 0.039 13.8 0.3 2.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 001199655.1_23527001_2 - 0.015 15.2 0.5 0.06 13.2 0.5 2.1 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.4 001199655.1_23527001_2 - 0.024 14.8 0.6 0.024 14.8 0.6 3.1 3 0 0 3 3 3 0 Ring finger domain zf-ANAPC11 PF12861.5 001199655.1_23527001_2 - 0.033 14.1 0.2 0.14 12.1 0.2 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.5 001199655.1_23527001_2 - 0.069 13.3 0.2 0.069 13.3 0.2 2.4 2 0 0 2 2 1 0 RING-H2 zinc finger domain DUF1664 PF07889.10 001199655.1_23527001_2 - 0.18 11.7 1.9 0.33 10.8 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) zf-RING_11 PF17123.3 001199655.1_23527001_2 - 1.8 8.3 10.4 0.027 14.0 0.9 2.9 2 0 0 2 2 2 0 RING-like zinc finger XhlA PF10779.7 001199655.1_23527001_2 - 3.6 7.7 6.1 0.9 9.6 2.3 2.1 2 0 0 2 2 1 0 Haemolysin XhlA Exonuc_VII_S PF02609.14 001199655.1_23527001_2 - 5.8 6.9 6.8 27 4.8 1.5 3.4 3 0 0 3 3 3 0 Exonuclease VII small subunit PRP21_like_P PF12230.6 001031472.2_23527001_1 - 2.3e-52 177.9 10.7 6.3e-52 176.4 10.7 1.8 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.18 001031472.2_23527001_1 - 6.9e-46 153.9 7.1 3.7e-24 84.3 0.4 2.6 2 0 0 2 2 2 2 Surp module ubiquitin PF00240.21 001031472.2_23527001_1 - 4e-17 61.6 0.1 8.3e-17 60.6 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.4 001031472.2_23527001_1 - 0.0044 17.3 0.0 0.013 15.8 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-like domain Toprim_Crpt PF13342.4 001031472.2_23527001_1 - 0.4 10.5 2.4 17 5.3 0.1 2.9 3 0 0 3 3 3 0 C-terminal repeat of topoisomerase UPF0560 PF10577.7 001031472.2_23527001_1 - 0.61 8.4 8.6 1.2 7.4 8.6 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 NADH_oxidored PF08040.9 001277785.1_23522001_3 - 7.4e-36 121.5 0.2 1.3e-35 120.8 0.2 1.4 1 0 0 1 1 1 1 MNLL subunit EVC2_like PF12297.6 001079749.2_23528001_1 - 2e-183 609.8 29.4 2e-183 609.8 29.4 4.1 5 0 0 5 5 5 1 Ellis van Creveld protein 2 like protein DUF4501 PF14946.4 001079749.2_23528001_1 - 0.026 14.5 0.2 0.056 13.4 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) Frag1 PF10277.7 001079749.2_23528001_1 - 0.047 13.1 0.3 0.081 12.3 0.3 1.2 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family PhosphMutase PF10143.7 001079749.2_23528001_1 - 7.8 6.2 5.9 13 5.5 0.1 3.0 3 0 0 3 3 3 0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase BTB_3 PF16017.3 001199575.1_23525001_3 - 3.3e-50 168.4 0.0 5.8e-50 167.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.20 001199575.1_23525001_3 - 0.0014 18.8 0.0 0.0037 17.5 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain RNA_pol_Rpc4 PF05132.12 001199575.1_23525001_3 - 0.075 13.3 0.1 0.14 12.4 0.1 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF1777 PF08648.10 001199575.1_23525001_3 - 1.1 9.4 13.5 1.7 8.7 13.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) DnaJ PF00226.29 001030735.1_23527001_3 - 5.1e-28 96.9 1.9 9.1e-28 96.1 1.9 1.4 1 0 0 1 1 1 1 DnaJ domain Transferrin PF00405.15 205207.2_23528001_1 - 4.9e-226 748.9 8.8 6.4e-120 400.1 1.3 2.1 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 205207.2_23528001_1 - 2.5e-13 50.0 0.0 2.7e-06 27.0 0.0 2.8 2 1 0 2 2 2 2 ABC transporter, phosphonate, periplasmic substrate-binding protein Jiv90 PF14901.4 205207.2_23528001_1 - 0.028 14.5 0.2 6.5 6.9 0.0 3.3 3 0 0 3 3 3 0 Cleavage inducing molecular chaperone SoxD PF04267.10 205207.2_23528001_1 - 0.037 14.0 2.4 0.25 11.3 0.1 2.6 3 0 0 3 3 3 0 Sarcosine oxidase, delta subunit family SBP_bac_3 PF00497.18 205207.2_23528001_1 - 0.12 11.6 0.0 2.1 7.6 0.0 2.3 2 0 0 2 2 2 0 Bacterial extracellular solute-binding proteins, family 3 NUDIX PF00293.26 001006160.2_23523001_1 - 4.9e-15 55.6 0.1 6.8e-15 55.1 0.1 1.2 1 0 0 1 1 1 1 NUDIX domain Filamin PF00630.17 204574.1_23529001_1 - 0 1230.5 10.6 7.1e-19 68.4 0.0 24.1 24 0 0 24 24 24 24 Filamin/ABP280 repeat CH PF00307.29 204574.1_23529001_1 - 1.2e-39 134.7 0.1 2.1e-20 72.8 0.3 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain Big_3_5 PF16640.3 204574.1_23529001_1 - 7.1e-17 61.2 54.2 0.22 11.6 0.0 16.8 17 0 0 17 17 17 7 Bacterial Ig-like domain (group 3) DUF5060 PF16586.3 204574.1_23529001_1 - 3.7e-11 43.1 0.0 4.3 7.6 0.0 10.0 12 0 0 12 12 11 2 Domain of unknown function (DUF5060) Y_Y_Y PF07495.11 204574.1_23529001_1 - 9.8e-11 41.3 4.0 1.7 8.5 0.0 10.7 12 0 0 12 12 12 1 Y_Y_Y domain Invasin_D3 PF09134.8 204574.1_23529001_1 - 1.6e-08 34.0 1.6 10 5.8 0.0 9.3 10 0 0 10 10 10 1 Invasin, domain 3 EMP24_GP25L PF01105.22 204574.1_23529001_1 - 0.00016 21.5 0.0 20 4.9 0.0 6.2 8 0 0 8 8 8 0 emp24/gp25L/p24 family/GOLD PapC_N PF13954.4 204574.1_23529001_1 - 0.008 16.0 0.0 0.7 9.7 0.0 3.9 4 0 0 4 4 4 1 PapC N-terminal domain Inhibitor_I42 PF09394.8 204574.1_23529001_1 - 0.2 11.9 2.1 51 4.2 0.0 5.6 5 0 0 5 5 5 0 Chagasin family peptidase inhibitor I42 Fimbrial_K88 PF02432.13 204574.1_23529001_1 - 0.45 9.9 2.7 5 6.5 0.1 3.6 4 0 0 4 4 4 0 Fimbrial, major and minor subunit PhnH PF05845.10 204574.1_23529001_1 - 0.53 9.9 4.4 3.9 7.0 0.1 4.2 5 0 0 5 5 5 0 Bacterial phosphonate metabolism protein (PhnH) CopC PF04234.10 204574.1_23529001_1 - 0.9 10.5 13.0 2.7e+02 2.5 0.0 9.1 11 0 0 11 11 9 0 CopC domain WAPL PF07814.11 001199511.1_23529001_3 - 1.7e-114 382.3 7.5 2.5e-114 381.7 7.5 1.3 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin NARP1 PF12569.6 001199511.1_23529001_3 - 0.085 11.6 0.0 0.085 11.6 0.0 2.4 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 FAD_binding_1 PF00667.18 001195796.1_23526001_2 - 1.3e-80 270.0 0.0 2e-80 269.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 001195796.1_23526001_2 - 2.6e-39 134.6 0.3 2.6e-39 134.6 0.3 2.0 3 0 0 3 3 3 1 Flavodoxin NAD_binding_1 PF00175.19 001195796.1_23526001_2 - 8.4e-19 68.1 0.0 2.8e-18 66.4 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Renin_r PF07850.12 001030801.2_23524001_2 - 3e-36 123.9 0.9 5.1e-36 123.1 0.9 1.4 1 0 0 1 1 1 1 Renin receptor-like protein HHH_2 PF12826.5 001277595.1_23523001_3 - 2.6e-08 33.7 0.0 4.9e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.4 001277595.1_23523001_3 - 2.8e-06 27.7 0.0 4.5e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Helix-hairpin-helix domain 5_3_exonuc PF01367.18 001277595.1_23523001_3 - 0.015 15.7 0.0 0.027 14.9 0.0 1.3 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold NUDIX PF00293.26 073539.2_23523120_2 - 1e-09 38.4 0.0 1.7e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain NUDIX PF00293.26 001278106.1_23523001_1 - 1.9e-16 60.2 0.3 8.9e-16 58.0 0.0 1.9 2 0 0 2 2 2 1 NUDIX domain NUDIX PF00293.26 001278105.1_23523001_3 - 2e-16 60.1 0.3 9.6e-16 57.9 0.0 1.9 2 0 0 2 2 2 1 NUDIX domain EI24 PF07264.9 001006316.2_23525001_1 - 2.2e-22 80.0 14.3 7.1e-22 78.4 14.3 1.8 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Med26 PF08711.9 001195594.1_23524001_2 - 3.9e-10 39.5 0.1 3.9e-10 39.5 0.1 2.1 3 0 0 3 3 3 1 TFIIS helical bundle-like domain TFIIS_M PF07500.12 001195594.1_23524001_2 - 2.5e-06 27.8 0.0 4.2e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain RecQ5 PF06959.9 204102.2_23529001_2 - 3.8e-26 92.2 14.5 3.8e-26 92.2 14.5 1.8 2 0 0 2 2 2 1 RecQ helicase protein-like 5 (RecQ5) DEAD PF00270.27 204102.2_23529001_2 - 2.5e-19 69.6 0.1 4.8e-19 68.7 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 204102.2_23529001_2 - 1.7e-15 57.2 0.0 7.8e-12 45.4 0.0 2.5 2 0 0 2 2 2 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.3 204102.2_23529001_2 - 7.7e-10 39.2 1.9 2.3e-09 37.6 1.9 1.9 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.13 204102.2_23529001_2 - 0.00011 22.2 0.0 0.00029 20.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SRI PF08236.9 204102.2_23529001_2 - 0.026 14.6 0.4 0.026 14.6 0.4 2.3 2 0 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain Sema PF01403.17 001319026.1_23526001_1 - 1e-125 419.8 0.0 1.4e-125 419.3 0.0 1.1 1 0 0 1 1 1 1 Sema domain PSI PF01437.23 001319026.1_23526001_1 - 5.4e-05 23.5 5.1 5.4e-05 23.5 5.1 1.8 2 0 0 2 2 2 1 Plexin repeat DUF1049 PF06305.9 001319026.1_23526001_1 - 0.12 12.1 0.1 0.29 10.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Reprolysin PF01421.17 001145230.1_23525001_1 - 2.9e-64 216.5 0.0 5.2e-64 215.7 0.0 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 001145230.1_23525001_1 - 1.4e-29 102.9 0.5 1.4e-29 102.9 0.5 1.7 2 0 0 2 2 2 1 Reprolysin family propeptide ADAM_CR PF08516.10 001145230.1_23525001_1 - 9.6e-26 90.3 8.4 9.6e-26 90.3 8.4 3.6 4 1 0 4 4 4 1 ADAM cysteine-rich Disintegrin PF00200.21 001145230.1_23525001_1 - 2.6e-17 63.2 25.1 2.6e-17 63.2 25.1 4.2 4 0 0 4 4 4 1 Disintegrin Reprolysin_5 PF13688.4 001145230.1_23525001_1 - 8.3e-08 32.5 0.4 3.4e-07 30.5 0.4 2.2 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 001145230.1_23525001_1 - 4.2e-07 30.4 0.0 1.2e-06 29.0 0.0 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.11 001145230.1_23525001_1 - 0.00035 20.7 10.5 0.00035 20.7 10.5 6.5 4 3 2 6 6 6 1 EGF-like domain RRM_1 PF00076.20 001277455.1_23522001_3 - 2.1e-15 56.2 0.0 2.9e-15 55.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRR_9 PF14580.4 001277456.1_23524001_3 - 8.1e-16 57.9 5.0 9.1e-16 57.7 3.1 2.1 2 0 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.5 001277456.1_23524001_3 - 1.2e-11 44.5 5.3 2.8e-05 24.2 0.5 3.8 1 1 3 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001277456.1_23524001_3 - 5.8e-06 25.8 6.2 1.7e-05 24.3 3.1 3.1 2 2 1 3 3 3 2 Leucine rich repeat Caldesmon PF02029.13 001277456.1_23524001_3 - 0.037 12.6 21.3 0.062 11.9 21.3 1.3 1 0 0 1 1 1 0 Caldesmon DUF1118 PF06549.10 001277456.1_23524001_3 - 0.16 12.2 0.1 0.37 10.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1118) LRR_1 PF00560.31 001277456.1_23524001_3 - 0.8 10.3 4.3 2.4e+02 2.7 0.1 5.0 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.4 001277456.1_23524001_3 - 1.4 9.0 4.5 27 5.0 0.1 3.8 4 0 0 4 4 4 0 Leucine Rich repeat Ribosomal_L35Ae PF01247.16 001277457.1_23522001_1 - 1.5e-46 156.4 0.5 3.1e-46 155.4 0.5 1.5 2 0 0 2 2 2 1 Ribosomal protein L35Ae T-box PF00907.20 204106.1_23526001_2 - 1.4e-77 259.9 0.1 1.8e-77 259.6 0.1 1.1 1 0 0 1 1 1 1 T-box His_Phos_1 PF00300.20 001030768.1_23529001_3 - 3e-32 111.8 0.0 6.1e-28 97.7 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) 7tm_1 PF00001.19 204119.1_23526001_2 - 6.4e-34 117.3 10.5 6.4e-34 117.3 10.5 2.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) DUF4690 PF15756.3 001277481.1_23522001_1 - 3.1e-43 146.2 0.1 4e-43 145.8 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4690) Hormone_recep PF00104.28 204124.1_23525001_1 - 2.6e-45 154.4 0.3 4.2e-45 153.7 0.3 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 204124.1_23525001_1 - 2.4e-31 107.8 15.6 5.5e-31 106.7 15.6 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Zona_pellucida PF00100.21 213576.2_23523001_2 - 5.8e-49 167.0 0.8 7.2e-49 166.7 0.8 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain EGF PF00008.25 213576.2_23523001_2 - 3.1e-06 27.2 7.5 3.1e-06 27.2 7.5 1.9 2 0 0 2 2 2 1 EGF-like domain EGF_2 PF07974.11 213576.2_23523001_2 - 0.024 14.9 7.8 0.053 13.8 7.8 1.6 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.5 213576.2_23523001_2 - 0.031 14.8 3.8 0.031 14.8 3.8 2.0 2 0 0 2 2 2 0 Human growth factor-like EGF cEGF PF12662.5 213576.2_23523001_2 - 0.064 13.1 1.7 0.14 12.0 1.7 1.6 1 0 0 1 1 1 0 Complement Clr-like EGF-like EGF_3 PF12947.5 213576.2_23523001_2 - 0.84 9.7 5.8 1.8 8.7 5.8 1.6 1 0 0 1 1 1 0 EGF domain Glyoxalase PF00903.23 001277491.1_23524001_3 - 3.2e-22 78.9 0.6 2.6e-14 53.4 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.4 001277491.1_23524001_3 - 2.2e-11 43.9 0.1 2.5e-05 24.4 0.1 2.5 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.4 001277491.1_23524001_3 - 0.0011 19.0 0.0 2.4 8.1 0.0 2.8 2 1 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_5 PF14696.4 001277491.1_23524001_3 - 0.0016 18.5 0.1 0.0058 16.7 0.1 1.8 2 0 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Ras PF00071.20 213579.1_23523001_1 - 3.3e-30 104.7 0.1 6.8e-30 103.7 0.0 1.5 2 0 0 2 2 2 1 Ras family Roc PF08477.11 213579.1_23523001_1 - 1.4e-08 34.9 0.0 2.9e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF258 PF03193.14 213579.1_23523001_1 - 4.7e-05 23.2 0.0 0.018 14.8 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 213579.1_23523001_1 - 0.00071 19.5 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 213579.1_23523001_1 - 0.00074 18.9 0.0 0.005 16.3 0.0 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.25 213579.1_23523001_1 - 0.00094 19.6 0.1 0.0026 18.2 0.0 1.8 2 1 0 2 2 2 1 ABC transporter AAA_22 PF13401.4 213579.1_23523001_1 - 0.0061 16.7 0.1 1.3 9.1 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.4 213579.1_23523001_1 - 0.038 14.2 0.0 0.092 13.0 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.4 213579.1_23523001_1 - 0.04 13.5 0.1 0.12 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.12 213579.1_23523001_1 - 0.11 12.4 0.0 0.28 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PCI PF01399.25 001030775.1_23524001_1 - 7.4e-07 29.5 0.4 2.4e-06 27.9 0.1 1.9 2 0 0 2 2 2 1 PCI domain Ribosomal_S3_C PF00189.18 001030775.1_23524001_1 - 0.05 14.0 0.2 0.092 13.1 0.2 1.4 1 0 0 1 1 1 0 Ribosomal protein S3, C-terminal domain Abhydrolase_2 PF02230.14 001162382.1_23524001_2 - 2.7e-86 288.8 0.0 3.6e-86 288.3 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.11 001162382.1_23524001_2 - 2.3e-06 27.5 0.0 1.2e-05 25.1 0.0 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 001162382.1_23524001_2 - 0.0002 20.6 0.1 0.28 10.3 0.0 2.9 2 1 1 3 3 3 2 Serine aminopeptidase, S33 DLH PF01738.16 001162382.1_23524001_2 - 0.00064 19.2 0.0 0.001 18.5 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.18 001162382.1_23524001_2 - 0.00088 18.8 0.3 0.026 14.1 0.3 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.11 001162382.1_23524001_2 - 0.0013 18.3 0.0 0.011 15.3 0.0 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.19 001162382.1_23524001_2 - 0.0018 17.7 0.3 0.99 8.7 0.0 3.3 3 1 1 4 4 4 1 Prolyl oligopeptidase family DUF2974 PF11187.6 001162382.1_23524001_2 - 0.014 14.9 0.0 0.022 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Cutinase PF01083.20 001162382.1_23524001_2 - 0.034 14.0 0.0 0.088 12.6 0.0 1.6 2 0 0 2 2 2 0 Cutinase F5_F8_type_C PF00754.23 001030783.1_23529001_2 - 4.3e-26 91.4 0.6 6.9e-26 90.7 0.6 1.3 1 0 0 1 1 1 1 F5/8 type C domain CUB PF00431.18 001030783.1_23529001_2 - 7.1e-14 52.0 0.0 1.2e-13 51.2 0.0 1.3 1 0 0 1 1 1 1 CUB domain LCCL PF03815.17 001030783.1_23529001_2 - 6.3e-13 48.5 0.0 1.2e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 LCCL domain Syndecan PF01034.18 001030783.1_23529001_2 - 0.029 14.1 0.0 0.073 12.9 0.0 1.6 1 0 0 1 1 1 0 Syndecan domain 7tm_1 PF00001.19 001162892.2_23523001_3 - 7.4e-32 110.5 15.2 9.3e-32 110.2 15.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001162892.2_23523001_3 - 0.00056 19.2 16.6 0.00096 18.4 16.6 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001162892.2_23523001_3 - 0.35 10.4 9.7 0.75 9.3 9.7 1.6 1 1 0 1 1 1 0 Olfactory receptor CAP-ZIP_m PF15255.4 001030789.1_23527001_2 - 6.8e-22 78.1 2.0 1.8e-21 76.8 2.0 1.6 1 0 0 1 1 1 1 WASH complex subunit CAP-Z interacting, central region ABC2_membrane_3 PF12698.5 204145.2_23529001_1 - 6.9e-60 202.8 49.4 7.7e-47 159.9 22.3 3.4 2 1 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.25 204145.2_23529001_1 - 3.8e-52 176.3 0.0 9.6e-29 100.5 0.0 2.8 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.4 204145.2_23529001_1 - 9.1e-20 71.5 0.1 2.6e-06 27.4 0.0 4.4 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.4 204145.2_23529001_1 - 7e-06 26.6 0.1 0.011 16.3 0.0 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF4162) AAA_29 PF13555.4 204145.2_23529001_1 - 0.0014 18.2 2.0 0.077 12.6 0.4 3.0 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_23 PF13476.4 204145.2_23529001_1 - 0.0057 17.1 4.9 0.017 15.5 0.2 2.6 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.4 204145.2_23529001_1 - 0.022 14.3 2.2 1.6 8.1 0.0 3.8 5 0 0 5 5 5 0 AAA ATPase domain SET PF00856.26 204155.1_23523001_1 - 2.1e-12 47.6 0.1 5.6e-12 46.2 0.1 1.8 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.16 204155.1_23523001_1 - 3.4e-09 36.5 17.5 3.4e-09 36.5 17.5 2.8 3 0 0 3 3 3 1 MYND finger TPR_12 PF13424.4 204155.1_23523001_1 - 0.005 17.0 0.0 0.021 15.0 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat DJ-1_PfpI PF01965.22 001030798.1_23524001_3 - 4.8e-05 23.1 0.6 0.00011 21.9 0.6 1.6 1 1 0 1 1 1 1 DJ-1/PfpI family Ldl_recept_b PF00058.15 001001292.1_23528001_1 - 1.9e-47 159.3 8.1 9.9e-11 41.8 0.0 8.9 11 0 0 11 11 11 6 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 001001292.1_23528001_1 - 1.3e-34 118.0 142.4 7.6e-08 32.4 8.3 11.4 10 1 1 11 11 11 8 Coagulation Factor Xa inhibitory site cEGF PF12662.5 001001292.1_23528001_1 - 9e-33 111.7 78.9 3.7e-06 26.6 2.1 11.5 11 0 0 11 11 11 10 Complement Clr-like EGF-like EGF_CA PF07645.13 001001292.1_23528001_1 - 1.8e-20 72.7 135.9 2.8e-08 33.7 10.3 11.4 10 1 1 11 11 11 5 Calcium-binding EGF domain EGF PF00008.25 001001292.1_23528001_1 - 3.8e-15 55.7 124.3 8.3e-05 22.7 5.5 11.2 11 0 0 11 11 11 8 EGF-like domain DUF5050 PF16472.3 001001292.1_23528001_1 - 6.9e-10 38.5 0.0 2.9e-06 26.6 0.0 3.2 2 2 0 2 2 2 2 Domain of unknown function (DUF5050) EGF_3 PF12947.5 001001292.1_23528001_1 - 6.7e-09 35.7 128.3 0.00023 21.1 13.4 10.7 10 0 0 10 10 10 6 EGF domain SGL PF08450.10 001001292.1_23528001_1 - 2.9e-07 30.2 0.2 0.022 14.2 0.0 4.3 3 1 1 4 4 4 2 SMP-30/Gluconolaconase/LRE-like region EGF PF00008.25 001001203.1_23522001_1 - 0.00076 19.6 3.4 0.00076 19.6 3.4 2.3 3 0 0 3 3 3 1 EGF-like domain EGF_2 PF07974.11 001001203.1_23522001_1 - 9.2 6.6 8.3 1.1 9.5 2.5 2.5 2 1 0 2 2 2 0 EGF-like domain EF-hand_4 PF12763.5 001030806.1_23529001_2 - 6.6e-17 61.2 0.0 2.8e-12 46.4 0.0 2.3 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.30 001030806.1_23529001_2 - 0.086 12.3 0.0 0.17 11.3 0.0 1.6 1 0 0 1 1 1 0 EF hand DUF4515 PF14988.4 001030806.1_23529001_2 - 0.088 12.5 4.6 0.14 11.9 4.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) EF-hand_7 PF13499.4 001030806.1_23529001_2 - 0.16 12.4 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair DUF766 PF05571.10 001277554.1_23523001_2 - 2.3e-114 381.9 12.1 2.9e-114 381.5 12.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF766) GTPase_binding PF09027.8 001277554.1_23523001_2 - 0.15 11.9 0.1 0.29 11.0 0.1 1.4 1 0 0 1 1 1 0 GTPase binding ATP-synt_C PF00137.19 001277572.1_23522001_2 - 6.3e-26 90.4 43.4 3.8e-14 52.6 10.3 3.5 3 1 0 3 3 3 2 ATP synthase subunit C PIRT PF15099.4 001277572.1_23522001_2 - 5.6 6.4 6.4 2.4 7.6 0.7 2.3 1 1 1 2 2 2 0 Phosphoinositide-interacting protein family UDPGT PF00201.16 204204.1_23524001_2 - 3.3e-121 405.4 0.0 4.1e-121 405.1 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 204204.1_23524001_2 - 1.1e-06 28.6 0.0 2.2e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Imm39 PF15568.4 204204.1_23524001_2 - 0.0029 17.6 0.1 0.0056 16.7 0.1 1.3 1 0 0 1 1 1 1 Immunity protein 39 HD_4 PF13328.4 001001613.1_23523001_1 - 0.014 15.0 0.2 0.02 14.5 0.2 1.1 1 0 0 1 1 1 0 HD domain MHC2-interact PF09307.8 001001613.1_23523001_3 - 1.4e-37 127.9 2.5 2.3e-37 127.2 2.5 1.3 1 0 0 1 1 1 1 CLIP, MHC2 interacting MHCassoc_trimer PF08831.8 001001613.1_23523001_3 - 4.7e-31 106.5 7.4 7.9e-31 105.7 7.4 1.4 1 0 0 1 1 1 1 Class II MHC-associated invariant chain trimerisation domain Thyroglobulin_1 PF00086.16 001001613.1_23523001_3 - 9.3e-14 50.7 7.2 1.8e-13 49.8 7.2 1.5 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat Ras PF00071.20 001030867.1_23529001_1 - 4.3e-54 182.4 0.0 5.9e-54 181.9 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001030867.1_23529001_1 - 1.5e-34 118.7 0.0 2.3e-34 118.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001030867.1_23529001_1 - 6.7e-13 48.3 0.0 1.1e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001030867.1_23529001_1 - 0.0016 18.4 0.0 0.0027 17.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001030867.1_23529001_1 - 0.0038 16.5 0.0 0.0056 15.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001030867.1_23529001_1 - 0.012 15.1 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001030867.1_23529001_1 - 0.044 13.6 0.0 1.3 8.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 RGS PF00615.17 204229.1_23525001_2 - 1.7e-34 118.5 1.1 2.4e-34 118.0 1.1 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF1455 PF07306.9 204229.1_23525001_2 - 0.023 14.6 2.0 0.066 13.1 2.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1455) zf-H2C2_2 PF13465.4 001030869.1_23526001_1 - 2.5e-44 147.7 82.1 4e-07 30.1 3.7 11.5 12 0 0 12 12 12 9 Zinc-finger double domain zf-C2H2 PF00096.24 001030869.1_23526001_1 - 2.6e-34 115.6 88.3 0.00019 21.5 0.9 11.8 11 0 0 11 11 11 10 Zinc finger, C2H2 type zf-H2C2_5 PF13909.4 001030869.1_23526001_1 - 3.5e-29 100.1 82.4 3.4e-07 29.8 0.9 10.6 10 0 0 10 10 10 8 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.4 001030869.1_23526001_1 - 4.7e-23 79.7 83.0 0.0027 18.3 0.9 11.7 11 0 0 11 11 11 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001030869.1_23526001_1 - 6.6e-10 38.6 9.2 5.5e-08 32.4 0.5 8.3 12 0 0 12 12 12 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001030869.1_23526001_1 - 0.00049 20.2 67.4 0.084 13.1 0.6 10.8 10 1 1 11 11 11 6 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001030869.1_23526001_1 - 0.0056 16.9 0.6 0.0056 16.9 0.6 10.5 11 1 0 11 11 11 5 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 001030869.1_23526001_1 - 0.053 13.2 0.1 0.053 13.2 0.1 7.8 8 0 0 8 8 8 0 zinc-finger C2H2-type FGF PF00167.16 001001743.1_23522001_3 - 1.4e-43 147.9 0.4 1.8e-43 147.4 0.4 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 001001743.1_23522001_3 - 0.00061 19.9 0.1 0.0035 17.4 0.0 1.9 2 0 0 2 2 2 1 Fascin domain PMP22_Claudin PF00822.18 001277622.1_23524001_1 - 2.1e-25 89.4 5.4 2.7e-25 89.0 5.4 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001277622.1_23524001_1 - 8.5e-07 28.8 6.6 2e-06 27.6 6.6 1.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Amastin PF07344.9 001277622.1_23524001_1 - 0.024 14.4 3.0 0.04 13.6 3.0 1.4 1 1 0 1 1 1 0 Amastin surface glycoprotein SAM_1 PF00536.28 001030877.1_23526001_1 - 8.4e-12 45.2 0.0 1.7e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 001030877.1_23526001_1 - 1.4e-10 41.0 0.3 3.2e-10 39.8 0.0 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Ste50p-SAM PF09235.8 001030877.1_23526001_1 - 0.0044 17.1 0.0 0.0078 16.3 0.0 1.4 1 0 0 1 1 1 1 Ste50p, sterile alpha motif SAM_PNT PF02198.14 001030877.1_23526001_1 - 0.011 15.5 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Pap_E4 PF02711.12 001030877.1_23526001_1 - 2.2 9.3 10.1 0.2 12.5 0.4 3.7 3 0 0 3 3 3 0 E4 protein Ribosomal_S18 PF01084.18 001277623.1_23522001_3 - 8.7e-16 57.7 0.0 1.8e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S18 Serinc PF03348.13 001030890.1_23524001_2 - 6.1e-158 526.1 15.8 7.3e-158 525.9 15.8 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) p450 PF00067.20 001001753.1_23524001_1 - 9.6e-77 258.5 0.8 1.5e-76 257.9 0.8 1.2 1 0 0 1 1 1 1 Cytochrome P450 TFIID_20kDa PF03847.11 001030894.2_23523001_2 - 1.3e-35 121.6 2.8 2.1e-35 120.9 2.8 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.21 001030894.2_23523001_2 - 2e-05 24.7 0.2 4e-05 23.7 0.2 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.22 001030894.2_23523001_2 - 8.3e-05 22.9 0.1 0.00019 21.7 0.1 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.13 001030894.2_23523001_2 - 0.00042 20.2 0.2 0.00088 19.2 0.1 1.5 1 1 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.4 001030894.2_23523001_2 - 0.024 14.6 0.1 0.047 13.7 0.1 1.4 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold TAF4 PF05236.12 001030894.2_23523001_2 - 0.041 13.5 0.0 0.051 13.2 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Macoilin PF09726.7 001030895.2_23527001_2 - 0 1106.6 18.8 0 1106.4 18.8 1.0 1 0 0 1 1 1 1 Transmembrane protein DUF812 PF05667.9 001030895.2_23527001_2 - 0.00092 18.1 39.0 0.00092 18.1 39.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF812) Reo_sigmaC PF04582.10 001030895.2_23527001_2 - 0.0058 15.9 7.1 0.19 10.9 1.0 2.3 2 0 0 2 2 2 2 Reovirus sigma C capsid protein GLE1 PF07817.11 001030895.2_23527001_2 - 1.9 7.5 14.0 1.2 8.1 0.3 2.4 2 0 0 2 2 2 0 GLE1-like protein fn3 PF00041.19 001030898.2_23526001_1 - 3e-19 69.0 0.2 1.1e-08 35.2 0.1 4.7 6 0 0 6 6 6 3 Fibronectin type III domain Lep_receptor_Ig PF06328.9 001030898.2_23526001_1 - 6.3e-13 48.4 0.0 1.7e-12 47.1 0.0 1.8 1 0 0 1 1 1 1 Ig-like C2-type domain fn3_2 PF16893.3 001030898.2_23526001_1 - 0.012 15.6 0.2 0.078 13.0 0.1 2.3 2 0 0 2 2 2 0 Fibronectin type III domain EpoR_lig-bind PF09067.8 001030898.2_23526001_1 - 0.048 13.7 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Erythropoietin receptor, ligand binding Sel1 PF08238.10 001277643.1_23523001_1 - 5.9e-16 58.4 2.3 2.5e-05 24.7 0.0 4.5 4 0 0 4 4 4 4 Sel1 repeat Ets PF00178.20 001030908.1_23527001_3 - 1.6e-35 121.3 0.4 3.5e-35 120.2 0.4 1.6 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 001030908.1_23527001_3 - 5e-25 87.2 0.1 1.1e-24 86.0 0.1 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Lipocalin PF00061.21 204259.1_23522001_1 - 3.4e-36 124.4 0.1 4.1e-36 124.2 0.1 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Triabin PF03973.11 204259.1_23522001_1 - 0.00097 18.9 0.0 0.0015 18.3 0.0 1.4 1 0 0 1 1 1 1 Triabin Lipocalin_2 PF08212.10 204259.1_23522001_1 - 0.1 12.4 0.2 0.26 11.1 0.2 1.6 1 1 0 1 1 1 0 Lipocalin-like domain Reprolysin_2 PF13574.4 204261.2_23529001_2 - 4.8e-33 114.6 0.1 4.8e-33 114.6 0.1 1.8 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 204261.2_23529001_2 - 8e-32 110.9 0.9 3.1e-31 108.9 0.1 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 204261.2_23529001_2 - 6.6e-27 94.4 0.0 1.1e-26 93.6 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 204261.2_23529001_2 - 2.4e-15 56.6 0.1 4.2e-15 55.8 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.21 204261.2_23529001_2 - 7.6e-14 52.1 32.3 7.6e-14 52.1 32.3 3.9 3 1 1 4 4 4 1 Disintegrin Pep_M12B_propep PF01562.17 204261.2_23529001_2 - 1.6e-11 44.4 1.0 3e-11 43.6 1.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin PF01421.17 204261.2_23529001_2 - 1.1e-06 28.6 0.8 4.6e-05 23.3 0.8 2.5 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Peptidase_M66 PF10462.7 204261.2_23529001_2 - 0.058 12.2 0.2 0.1 11.4 0.2 1.3 1 0 0 1 1 1 0 Peptidase M66 SUFU_C PF12470.6 204264.1_23523001_1 - 5.4e-86 287.8 0.0 7.2e-86 287.4 0.0 1.2 1 0 0 1 1 1 1 Suppressor of Fused Gli/Ci N terminal binding domain SUFU PF05076.11 204264.1_23523001_1 - 1.1e-51 175.1 0.0 1.5e-51 174.6 0.0 1.2 1 0 0 1 1 1 1 Suppressor of fused protein (SUFU) PRP38 PF03371.13 001277667.1_23523001_3 - 2.5e-63 213.0 0.9 3.2e-63 212.6 0.9 1.1 1 0 0 1 1 1 1 PRP38 family PRP38_assoc PF12871.5 001277667.1_23523001_3 - 6.5e-07 29.7 37.6 6.5e-07 29.7 37.6 2.2 1 1 1 2 2 2 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF2457 PF10446.7 001277667.1_23523001_3 - 0.11 11.6 33.2 0.18 10.8 33.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Ank_2 PF12796.5 001277670.1_23524001_1 - 8.3e-25 87.1 0.2 8.3e-12 45.4 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.4 001277670.1_23524001_1 - 1.1e-21 74.5 1.1 0.00097 19.3 0.0 6.0 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.28 001277670.1_23524001_1 - 2.4e-20 71.9 7.0 1e-05 25.6 0.1 6.0 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.4 001277670.1_23524001_1 - 1.1e-19 70.3 0.2 6.5e-10 39.2 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 001277670.1_23524001_1 - 8.1e-18 64.1 1.8 0.0013 18.9 0.0 5.4 3 1 2 5 5 5 4 Ankyrin repeats (many copies) SOCS_box PF07525.14 001277670.1_23524001_1 - 1e-05 25.6 0.6 1e-05 25.6 0.6 2.4 2 0 0 2 2 2 1 SOCS box Use1 PF09753.7 001030939.1_23525001_1 - 2.2e-49 168.3 4.0 2.7e-49 168.0 4.0 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 MCU PF04678.11 001030939.1_23525001_1 - 0.00061 19.9 0.8 0.00086 19.4 0.8 1.2 1 0 0 1 1 1 1 Mitochondrial calcium uniporter DUF4870 PF09685.8 001030939.1_23525001_1 - 0.0049 16.8 0.0 0.01 15.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4870) Synaptonemal_3 PF15191.4 001030939.1_23525001_1 - 0.21 11.3 1.1 0.34 10.6 1.1 1.2 1 0 0 1 1 1 0 Synaptonemal complex central element protein 3 Use1 PF09753.7 001030939.1_23525001_3 - 9.3e-41 140.0 1.4 1.3e-40 139.5 1.4 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 SNARE_assoc PF09335.9 001277687.1_23522001_2 - 1.2e-08 35.3 2.1 2.5e-08 34.3 0.4 2.1 2 0 0 2 2 2 1 SNARE associated Golgi protein ThiW PF09512.8 001277687.1_23522001_2 - 0.0061 16.5 0.1 0.011 15.7 0.1 1.5 1 0 0 1 1 1 1 Thiamine-precursor transporter protein (ThiW) Methyltransf_PK PF05891.10 001277688.1_23523001_1 - 3e-92 307.9 0.0 3.7e-92 307.7 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.4 001277688.1_23523001_1 - 3.3e-12 46.8 0.0 8.1e-12 45.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.10 001277688.1_23523001_1 - 2.4e-10 40.8 0.0 4.5e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001277688.1_23523001_1 - 7.9e-09 36.0 0.0 1.7e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.16 001277688.1_23523001_1 - 1.4e-05 24.3 0.0 2.1e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_31 PF13847.4 001277688.1_23523001_1 - 0.00013 21.6 0.0 0.00019 21.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 001277688.1_23523001_1 - 0.00022 20.5 0.0 0.00033 19.9 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.12 001277688.1_23523001_1 - 0.064 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_PK PF05891.10 001277689.1_23523001_1 - 2.7e-92 308.1 0.0 3.3e-92 307.8 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.4 001277689.1_23523001_1 - 3.2e-12 46.9 0.0 7.5e-12 45.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.10 001277689.1_23523001_1 - 2.5e-10 40.7 0.0 4.2e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001277689.1_23523001_1 - 8.9e-09 35.8 0.0 1.6e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.16 001277689.1_23523001_1 - 1.3e-05 24.4 0.0 2.6e-05 23.4 0.0 1.3 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_31 PF13847.4 001277689.1_23523001_1 - 0.00013 21.7 0.0 0.00018 21.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 001277689.1_23523001_1 - 0.0002 20.6 0.0 0.00031 20.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.12 001277689.1_23523001_1 - 0.06 12.8 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Rad21_Rec8_N PF04825.11 001030950.1_23528001_1 - 3.8e-40 136.3 0.0 6.9e-40 135.5 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.14 001030950.1_23528001_1 - 1.4e-22 78.6 0.2 4.6e-22 77.0 0.1 2.0 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein SMC_ScpA PF02616.12 001030950.1_23528001_1 - 0.0012 18.6 0.1 0.0028 17.5 0.1 1.5 1 0 0 1 1 1 1 Segregation and condensation protein ScpA SUIM_assoc PF16619.3 001030950.1_23528001_1 - 0.013 15.4 2.2 0.052 13.5 2.2 2.0 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 WH1 PF00568.21 204300.1_23527001_1 - 1e-39 134.8 0.1 1.7e-39 134.1 0.1 1.3 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.9 204300.1_23527001_1 - 1.9e-17 62.4 3.3 3.4e-17 61.6 3.3 1.4 1 0 0 1 1 1 1 VASP tetramerisation domain Fibrinogen_C PF00147.16 001277699.1_23525001_1 - 6.7e-74 248.3 12.1 9e-74 247.8 12.1 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fer4_NifH PF00142.16 001277699.1_23525001_1 - 0.071 12.4 1.7 0.13 11.6 1.4 1.5 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family DUF16 PF01519.14 001277699.1_23525001_1 - 2.8 8.3 11.6 1.6 9.1 4.3 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 IncA PF04156.12 001277699.1_23525001_1 - 4.3 7.0 10.6 8.5 6.0 10.6 1.4 1 0 0 1 1 1 0 IncA protein APP_E2 PF12925.5 204308.1_23527001_1 - 4.2e-73 245.0 19.9 7e-73 244.3 19.9 1.3 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.14 204308.1_23527001_1 - 2.4e-44 149.7 0.7 2.4e-44 149.7 0.7 2.1 2 0 0 2 2 2 1 Amyloid A4 N-terminal heparin-binding Beta-APP PF03494.11 204308.1_23527001_1 - 8.9e-27 92.5 1.7 1.5e-26 91.8 1.7 1.4 1 0 0 1 1 1 1 Beta-amyloid peptide (beta-APP) APP_amyloid PF10515.7 204308.1_23527001_1 - 2.4e-25 88.7 0.3 8.7e-25 86.9 0.3 2.0 1 0 0 1 1 1 1 beta-amyloid precursor protein C-terminus APP_Cu_bd PF12924.5 204308.1_23527001_1 - 6.1e-25 87.6 3.9 6.1e-25 87.6 3.9 2.2 2 0 0 2 2 2 1 Copper-binding of amyloid precursor, CuBD Kunitz_BPTI PF00014.21 204308.1_23527001_1 - 2.6e-19 69.0 6.2 5e-19 68.1 6.2 1.5 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Activator-TraM PF11657.6 204308.1_23527001_1 - 0.27 10.9 6.1 0.71 9.6 6.1 1.6 1 0 0 1 1 1 0 Transcriptional activator TraM MAS20 PF02064.13 204308.1_23527001_1 - 2 8.4 8.9 5.4 7.0 8.9 1.7 1 0 0 1 1 1 0 MAS20 protein import receptor zf-3CxxC PF13695.4 001171543.1_23523001_1 - 7.1e-09 35.9 16.6 1.2e-08 35.2 16.6 1.3 1 0 0 1 1 1 1 Zinc-binding domain zf-3CxxC_2 PF17180.2 001171543.1_23523001_1 - 0.00023 21.7 22.3 0.00023 21.7 22.3 2.4 2 1 0 2 2 2 1 Zinc-binding domain HMA PF00403.24 001277712.1_23521001_3 - 1.2e-09 38.3 0.0 1.7e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Heavy-metal-associated domain Astacin PF01400.22 001277721.1_23525001_3 - 7.2e-68 227.8 0.0 1.2e-67 227.2 0.0 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) MAM PF00629.21 001277721.1_23525001_3 - 3e-37 127.8 0.4 7.1e-37 126.6 0.3 1.7 2 0 0 2 2 2 1 MAM domain, meprin/A5/mu EGF PF00008.25 001277721.1_23525001_3 - 1.3e-09 38.0 6.6 3.7e-09 36.6 6.6 1.8 1 0 0 1 1 1 1 EGF-like domain EGF_CA PF07645.13 001277721.1_23525001_3 - 0.09 12.9 6.3 0.26 11.4 6.3 1.8 1 0 0 1 1 1 0 Calcium-binding EGF domain hEGF PF12661.5 001277721.1_23525001_3 - 0.33 11.6 10.0 0.18 12.4 6.9 2.3 2 0 0 2 2 2 0 Human growth factor-like EGF EGF_2 PF07974.11 001277721.1_23525001_3 - 0.42 10.9 12.2 0.32 11.3 8.5 2.6 2 0 0 2 2 2 0 EGF-like domain C1q PF00386.19 001171768.1_23526001_1 - 2.6e-26 92.2 0.3 3.9e-26 91.6 0.3 1.3 1 0 0 1 1 1 1 C1q domain Lipase_GDSL_2 PF13472.4 001277729.1_23522001_3 - 1.6e-25 90.4 0.0 2.6e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.20 001277729.1_23522001_3 - 1.2e-18 67.7 0.0 2.3e-18 66.8 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase RRM_1 PF00076.20 001030985.1_23524001_2 - 3.3e-32 110.0 0.0 9.8e-15 54.0 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001030985.1_23524001_2 - 6.3e-09 35.7 0.0 0.0006 19.8 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 001030985.1_23524001_2 - 0.045 13.6 0.2 0.49 10.3 0.1 2.4 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Nicastrin PF05450.13 001004413.2_23526001_2 - 8.1e-71 238.1 0.3 1.1e-70 237.6 0.3 1.2 1 0 0 1 1 1 1 Nicastrin Peptidase_M28 PF04389.15 001004413.2_23526001_2 - 2.5e-08 33.7 0.0 4.1e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Nebulin PF00880.16 001177329.1_23522001_1 - 1.5e-21 75.8 2.6 3.5e-10 39.5 0.3 2.6 2 0 0 2 2 2 2 Nebulin repeat SH3_9 PF14604.4 001177329.1_23522001_1 - 1.5e-15 56.7 0.1 2.3e-15 56.0 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001177329.1_23522001_1 - 3.7e-13 48.7 0.1 6.4e-13 48.0 0.1 1.4 1 0 0 1 1 1 1 SH3 domain LIM PF00412.20 001177329.1_23522001_1 - 2.4e-12 46.7 11.5 2.4e-12 46.7 11.5 1.6 2 0 0 2 2 2 1 LIM domain SH3_2 PF07653.15 001177329.1_23522001_1 - 3.5e-08 32.9 0.0 9.4e-08 31.5 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain zf-C2HC5 PF06221.11 001177329.1_23522001_1 - 0.24 11.3 5.2 0.6 10.0 5.2 1.7 1 1 0 1 1 1 0 Putative zinc finger motif, C2HC5-type Extensin_2 PF04554.11 001177329.1_23522001_1 - 3.5 7.6 14.3 0.23 11.4 9.2 1.7 2 0 0 2 2 2 0 Extensin-like region Ig_3 PF13927.4 001004768.1_23526001_1 - 1.2e-33 115.4 1.6 2.7e-08 34.2 0.0 5.4 5 0 0 5 5 5 4 Immunoglobulin domain Ig_2 PF13895.4 001004768.1_23526001_1 - 4e-29 100.7 3.0 6.1e-08 32.8 0.0 5.7 5 1 0 5 5 5 4 Immunoglobulin domain C2-set_2 PF08205.10 001004768.1_23526001_1 - 8.6e-29 99.3 0.1 1.6e-24 85.7 0.1 4.2 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001004768.1_23526001_1 - 3.3e-20 71.9 2.3 0.0016 18.4 0.1 5.8 5 1 0 5 5 5 4 Immunoglobulin domain I-set PF07679.14 001004768.1_23526001_1 - 3.4e-18 65.4 0.5 2.9e-05 23.9 0.0 5.8 5 3 0 5 5 5 4 Immunoglobulin I-set domain V-set PF07686.15 001004768.1_23526001_1 - 3.5e-08 33.4 5.9 0.036 14.1 0.1 6.1 5 2 0 5 5 5 2 Immunoglobulin V-set domain C1-set PF07654.13 001004768.1_23526001_1 - 5e-05 23.6 1.9 0.0017 18.6 0.1 3.8 4 1 0 4 4 4 1 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 001004768.1_23526001_1 - 0.023 14.6 0.0 0.71 9.8 0.0 2.6 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain C2-set PF05790.13 001004768.1_23526001_1 - 0.029 14.4 0.9 5.2 7.2 0.0 3.7 4 0 0 4 4 4 0 Immunoglobulin C2-set domain P12 PF12669.5 001004768.1_23526001_1 - 0.88 9.9 7.4 2.4 8.5 7.4 1.7 1 0 0 1 1 1 0 Virus attachment protein p12 family Homeobox PF00046.27 001005427.1_23524001_2 - 4.5e-22 77.5 7.5 4.5e-22 77.5 7.5 1.7 2 0 0 2 2 2 1 Homeobox domain SelP_N PF04592.12 001005427.1_23524001_2 - 0.49 9.6 17.6 1.2 8.4 17.6 1.6 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Caveolin PF01146.15 001007086.1_23523001_2 - 1.8e-55 186.4 0.4 2.9e-55 185.7 0.4 1.3 1 0 0 1 1 1 1 Caveolin adh_short PF00106.23 001031002.1_23524001_1 - 4.7e-55 186.0 0.0 5.9e-55 185.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001031002.1_23524001_1 - 1.5e-29 103.1 0.0 2.1e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001031002.1_23524001_1 - 1e-13 51.5 0.0 1.5e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.16 001031002.1_23524001_1 - 0.0016 18.6 0.2 0.0026 17.9 0.2 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.13 001031002.1_23524001_1 - 0.0025 16.9 0.2 0.0034 16.4 0.2 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.4 001031002.1_23524001_1 - 0.025 14.4 0.0 0.042 13.6 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H-binding 3Beta_HSD PF01073.17 001031002.1_23524001_1 - 0.072 11.9 1.0 0.11 11.4 1.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.17 001031002.1_23524001_1 - 0.075 12.2 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ApbA PF02558.14 001031002.1_23524001_1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF1776 PF08643.8 001031002.1_23524001_1 - 0.13 11.4 0.0 0.22 10.7 0.0 1.3 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) Geminin PF07412.10 001031010.2_23523001_1 - 1.1e-77 260.1 13.9 1.4e-77 259.8 13.9 1.1 1 0 0 1 1 1 1 Geminin DivIC PF04977.13 001031010.2_23523001_1 - 0.033 13.8 1.5 0.081 12.6 1.5 1.7 1 0 0 1 1 1 0 Septum formation initiator PGA2 PF07543.10 001031010.2_23523001_1 - 0.11 12.4 6.5 0.18 11.6 6.5 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 DUF5101 PF17031.3 001031010.2_23523001_1 - 0.15 12.0 9.7 0.15 12.0 1.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF5101) Fzo_mitofusin PF04799.11 001031010.2_23523001_1 - 0.19 11.1 2.5 0.3 10.5 2.5 1.3 1 0 0 1 1 1 0 fzo-like conserved region DUF342 PF03961.11 001031010.2_23523001_1 - 0.28 9.6 4.0 0.34 9.3 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Phage_GPO PF05929.9 001031010.2_23523001_1 - 2.3 7.6 6.3 3.3 7.2 6.3 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase CCDC-167 PF15188.4 001031010.2_23523001_1 - 2.4 8.4 8.7 6.1 7.1 8.7 1.8 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 Caveolin PF01146.15 204370.2_23523001_1 - 1.2e-58 196.7 1.0 1.7e-58 196.2 1.0 1.2 1 0 0 1 1 1 1 Caveolin DHHA1 PF02272.17 001005836.1_23527001_1 - 8.6e-07 28.8 0.7 1.4e-06 28.1 0.7 1.3 1 0 0 1 1 1 1 DHHA1 domain tRNA-synt_2c PF01411.17 001005836.1_23527001_2 - 1.2e-226 753.4 0.0 2e-226 752.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.12 001005836.1_23527001_2 - 3.8e-17 62.0 0.1 8.9e-17 60.8 0.1 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Lipase_GDSL_3 PF14606.4 001005836.1_23527001_2 - 0.035 14.1 0.1 0.086 12.8 0.1 1.6 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Syntaxin-6_N PF09177.9 001005836.1_23527001_2 - 0.069 13.6 1.8 0.19 12.1 1.8 1.7 1 0 0 1 1 1 0 Syntaxin 6, N-terminal LINES_N PF14694.4 001005836.1_23527001_2 - 0.081 12.2 0.2 0.13 11.6 0.2 1.2 1 0 0 1 1 1 0 Lines N-terminus Spc7 PF08317.9 001005836.1_23527001_2 - 0.22 10.3 2.8 0.41 9.4 2.8 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein PGI PF00342.17 001006128.1_23525001_2 - 1.7e-261 867.8 0.0 2e-261 867.6 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase DUF4473 PF14747.4 001006128.1_23525001_2 - 0.018 15.4 0.1 0.056 13.9 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) DHO_dh PF01180.19 001006131.2_23524001_3 - 4.1e-111 370.8 0.0 4.9e-111 370.5 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.16 001006131.2_23524001_3 - 0.0023 16.9 0.2 0.0055 15.6 0.2 1.6 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.13 001006131.2_23524001_3 - 0.0032 16.8 0.1 0.0056 16.0 0.1 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase adh_short PF00106.23 001277784.1_23524001_2 - 6e-58 195.4 0.2 7.8e-58 195.0 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001277784.1_23524001_2 - 2.9e-44 151.3 0.0 4e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001277784.1_23524001_2 - 1.6e-13 50.8 0.1 2.5e-13 50.2 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 001277784.1_23524001_2 - 2.4e-08 33.6 0.0 3.3e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 001277784.1_23524001_2 - 9.3e-06 25.1 0.1 1.2e-05 24.7 0.1 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.17 001277784.1_23524001_2 - 9.3e-05 21.4 0.1 0.00013 20.9 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.11 001277784.1_23524001_2 - 0.00024 20.6 0.4 0.00035 20.1 0.4 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.4 001277784.1_23524001_2 - 0.00035 20.4 0.2 0.00056 19.7 0.2 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Methyltransf_31 PF13847.4 001277784.1_23524001_2 - 0.0055 16.4 0.0 0.008 15.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Polysacc_synt_2 PF02719.13 001277784.1_23524001_2 - 0.0095 15.0 0.1 0.014 14.5 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 2-Hacid_dh_C PF02826.17 001277784.1_23524001_2 - 0.095 11.9 0.1 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Esterase PF00756.18 001277791.1_23523001_3 - 3.3e-70 236.4 0.0 4.2e-70 236.1 0.0 1.1 1 0 0 1 1 1 1 Putative esterase Chlorophyllase2 PF12740.5 001277791.1_23523001_3 - 1.3e-06 27.4 0.0 2.2e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.6 001277791.1_23523001_3 - 7.2e-05 22.0 0.0 0.00012 21.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.19 001277791.1_23523001_3 - 8.4e-05 22.0 0.0 0.00015 21.2 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase_phd PF10503.7 001277791.1_23523001_3 - 0.00021 20.7 0.0 0.0025 17.2 0.0 2.0 1 1 0 1 1 1 1 Esterase PHB depolymerase Chlorophyllase PF07224.9 001277791.1_23523001_3 - 0.0013 17.6 0.0 0.019 13.8 0.0 2.3 2 1 0 2 2 2 1 Chlorophyllase Lipase_3 PF01764.23 001277791.1_23523001_3 - 0.051 13.3 0.0 0.083 12.6 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_2 PF02230.14 001277791.1_23523001_3 - 0.067 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase DLH PF01738.16 001277791.1_23523001_3 - 0.099 12.0 0.0 0.24 10.8 0.0 1.7 1 1 0 1 1 1 0 Dienelactone hydrolase family GOLD_2 PF13897.4 001031043.1_23527001_3 - 5.9e-70 234.0 4.7 5.9e-70 234.0 4.7 2.6 2 1 1 3 3 3 1 Golgi-dynamics membrane-trafficking ACBP PF00887.17 001031043.1_23527001_3 - 2e-14 53.5 0.0 4.3e-14 52.3 0.0 1.6 1 0 0 1 1 1 1 Acyl CoA binding protein RR_TM4-6 PF06459.10 001031043.1_23527001_3 - 0.69 9.5 21.2 0.39 10.4 15.6 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Pkinase PF00069.23 204401.2_23527001_1 - 3.7e-34 118.1 0.0 5.5e-34 117.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 204401.2_23527001_1 - 1.1e-17 64.1 0.0 1.6e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 204401.2_23527001_1 - 0.0001 21.6 0.0 0.00015 21.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like tRNA-synt_2c PF01411.17 001031056.1_23527001_1 - 1.7e-190 634.1 0.0 2.2e-190 633.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.12 001031056.1_23527001_1 - 2.8e-07 30.4 0.6 1.7e-06 27.9 0.0 2.6 3 0 0 3 3 3 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.17 001031056.1_23527001_1 - 0.015 15.2 0.0 0.033 14.1 0.0 1.6 1 0 0 1 1 1 0 DHHA1 domain CBF PF03914.15 001031060.1_23527001_2 - 1.5e-53 181.0 3.2 3.9e-53 179.7 0.2 2.6 2 0 0 2 2 2 1 CBF/Mak21 family Cnd1 PF12717.5 001031060.1_23527001_2 - 0.00065 19.6 0.8 0.002 18.0 0.8 1.7 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 LCM PF04072.12 001006167.2_23524001_2 - 4.2e-41 140.8 0.0 7.5e-41 140.0 0.0 1.4 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase PDCD2_C PF04194.11 001031064.1_23523001_1 - 3.7e-49 166.9 0.8 2.5e-47 160.9 0.7 2.2 2 0 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain zf-MYND PF01753.16 001031064.1_23523001_1 - 1.9e-07 30.9 10.7 1.9e-07 30.9 10.7 2.5 3 0 0 3 3 3 1 MYND finger BTB PF00651.29 001031070.1_23527001_3 - 1.5e-18 66.9 0.2 2.9e-18 66.0 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 001031070.1_23527001_3 - 9.8e-13 47.7 30.2 0.00052 20.2 1.5 5.0 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001031070.1_23527001_3 - 1.8e-10 40.6 21.1 0.00021 21.5 2.8 5.9 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 001031070.1_23527001_3 - 4.1e-09 36.4 23.3 0.027 15.2 1.3 5.4 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.5 001031070.1_23527001_3 - 3e-05 24.1 30.8 0.25 11.7 1.7 5.1 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001031070.1_23527001_3 - 3.7e-05 23.8 16.7 0.039 14.1 0.1 4.8 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001031070.1_23527001_3 - 0.0074 16.1 24.2 0.85 9.5 0.3 4.8 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2HE PF16278.3 001031070.1_23527001_3 - 0.66 10.3 15.7 15 6.0 0.1 4.3 3 1 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2HC_2 PF13913.4 001031070.1_23527001_3 - 1.8 8.4 18.8 0.69 9.8 0.4 4.3 4 0 0 4 4 4 0 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.5 001031070.1_23527001_3 - 2.5 8.3 17.1 12 6.2 0.7 3.4 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) Topoisom_bac PF01131.18 001006181.1_23526001_1 - 1.4e-117 393.1 0.0 1.7e-117 392.8 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.20 001006181.1_23526001_1 - 1.2e-19 70.3 0.0 2.4e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 Toprim domain DUF2204 PF09970.7 001006181.1_23526001_1 - 0.14 11.6 0.1 0.85 9.1 0.0 2.0 2 0 0 2 2 2 0 Nucleotidyl transferase of unknown function (DUF2204) FoP_duplication PF13865.4 001006181.1_23526001_1 - 4.8 7.7 7.8 9.5 6.7 7.8 1.4 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 IL8 PF00048.18 204438.2_23522001_2 - 1.2e-18 66.9 0.1 2.3e-18 65.9 0.1 1.5 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like PAP2_C PF14360.4 001277826.1_23524001_2 - 6.4e-26 90.5 14.1 6.4e-26 90.5 14.1 2.0 2 0 0 2 2 2 1 PAP2 superfamily C-terminal PAP2 PF01569.19 001277826.1_23524001_2 - 1.5e-05 24.6 11.1 1.5e-05 24.6 11.1 1.9 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.4 001277826.1_23524001_2 - 0.037 13.6 12.9 0.024 14.2 8.9 2.2 2 0 0 2 2 2 0 PAP2 superfamily NOA36 PF06524.10 001277828.1_23523001_3 - 8.7e-162 537.6 45.7 1.1e-161 537.3 45.7 1.0 1 0 0 1 1 1 1 NOA36 protein SEP PF08059.11 001031094.1_23525001_1 - 7e-26 90.5 0.3 1.3e-25 89.7 0.3 1.4 1 0 0 1 1 1 1 SEP domain UBX PF00789.18 001031094.1_23525001_1 - 7.1e-14 51.6 0.0 1.5e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 UBX domain ACTH_domain PF00976.16 001031098.1_23522001_1 - 7.6e-25 86.2 27.8 1.8e-08 34.0 4.3 3.5 3 0 0 3 3 3 3 Corticotropin ACTH domain NPP PF08384.8 001031098.1_23522001_1 - 1.5e-23 82.4 1.2 2.5e-23 81.7 1.2 1.4 1 0 0 1 1 1 1 Pro-opiomelanocortin, N-terminal region Op_neuropeptide PF08035.9 001031098.1_23522001_1 - 5.9e-15 54.7 0.1 9.7e-15 54.0 0.1 1.4 1 0 0 1 1 1 1 Opioids neuropeptide COBRA1 PF06209.11 001006202.1_23525001_1 - 6.4e-244 809.9 3.1 7.8e-244 809.6 3.1 1.1 1 0 0 1 1 1 1 Cofactor of BRCA1 (COBRA1) Keratin PF02422.14 204448.2_23522001_2 - 1.3e-36 124.1 19.7 9.4e-36 121.3 19.7 2.1 1 1 0 1 1 1 1 Keratin ABM PF03992.14 204448.2_23522001_3 - 0.012 15.6 0.9 0.022 14.7 0.9 1.4 1 0 0 1 1 1 0 Antibiotic biosynthesis monooxygenase OGG_N PF07934.10 001277838.1_23523001_3 - 5.6e-30 103.8 0.0 7.8e-30 103.3 0.0 1.2 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.23 001277838.1_23523001_3 - 2.2e-15 56.9 0.0 3.4e-15 56.3 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.21 001277838.1_23523001_3 - 0.0067 16.1 0.3 0.016 14.9 0.0 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif Met_synt_B12 PF02965.15 001031104.1_23529001_2 - 4.1e-102 341.2 0.0 6e-102 340.6 0.0 1.3 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain S-methyl_trans PF02574.14 001031104.1_23529001_2 - 4.7e-79 265.8 0.1 1e-78 264.7 0.0 1.6 2 0 0 2 2 2 1 Homocysteine S-methyltransferase Pterin_bind PF00809.20 001031104.1_23529001_2 - 8.2e-59 199.1 0.2 2.8e-58 197.3 0.0 2.0 3 0 0 3 3 3 1 Pterin binding enzyme B12-binding_2 PF02607.15 001031104.1_23529001_2 - 4.9e-24 84.4 0.0 1.1e-23 83.3 0.0 1.7 1 0 0 1 1 1 1 B12 binding domain B12-binding PF02310.17 001031104.1_23529001_2 - 6.1e-18 64.9 0.3 1.8e-17 63.4 0.3 1.8 1 0 0 1 1 1 1 B12 binding domain CdhD PF03599.14 001031104.1_23529001_2 - 0.0059 15.2 0.0 0.011 14.4 0.0 1.3 1 0 0 1 1 1 1 CO dehydrogenase/acetyl-CoA synthase delta subunit IPT PF01745.14 001031104.1_23529001_2 - 0.086 12.1 0.1 0.24 10.6 0.1 1.8 2 0 0 2 2 2 0 Isopentenyl transferase Sec7 PF01369.18 001031105.2_23525001_3 - 2.4e-68 229.3 0.1 3.2e-68 228.9 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.27 001031105.2_23525001_3 - 1.8e-29 102.2 0.1 3.1e-29 101.4 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 001031105.2_23525001_3 - 5e-05 23.5 0.0 0.00011 22.4 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 001031105.2_23525001_3 - 0.01 16.0 0.0 0.033 14.3 0.0 1.8 2 0 0 2 2 2 0 Pleckstrin homology domain PH_3 PF14593.4 001031105.2_23525001_3 - 0.02 14.8 0.1 0.071 13.1 0.1 1.8 1 1 0 1 1 1 0 PH domain GPS2_interact PF15784.3 001031105.2_23525001_3 - 0.043 14.4 1.7 0.098 13.2 1.7 1.5 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain BBS2_C PF14782.4 001031105.2_23525001_3 - 0.16 10.6 1.0 2.4 6.7 0.6 2.0 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal APG6 PF04111.10 001031105.2_23525001_3 - 0.48 9.6 4.0 0.56 9.4 2.8 1.6 2 0 0 2 2 2 0 Autophagy protein Apg6 NUDE_C PF04880.11 001031105.2_23525001_3 - 1.1 9.6 4.1 2 8.7 4.1 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region SLY PF12485.6 001031110.1_23525001_2 - 2.3e-46 158.2 3.9 4.7e-46 157.2 3.9 1.5 1 0 0 1 1 1 1 Lymphocyte signaling adaptor protein SAM_2 PF07647.15 001031110.1_23525001_2 - 8.4e-09 35.3 0.6 1.4e-08 34.6 0.6 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001031110.1_23525001_2 - 2.6e-08 34.1 0.2 4.4e-08 33.3 0.2 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.15 001031110.1_23525001_2 - 2.1e-05 24.0 0.0 3.9e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001031110.1_23525001_2 - 0.013 15.0 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 SH3 domain Spindle_Spc25 PF08234.10 001277857.1_23523001_1 - 1.1e-22 79.8 0.3 1.1e-22 79.8 0.3 2.1 2 1 0 2 2 2 1 Chromosome segregation protein Spc25 Spc7 PF08317.9 001277857.1_23523001_1 - 4.4e-06 25.7 18.3 6.1e-06 25.2 18.3 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Tox-ODYAM1 PF15642.4 001277857.1_23523001_1 - 0.03 13.1 9.2 0.041 12.7 9.2 1.2 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus Atg14 PF10186.7 001277857.1_23523001_1 - 0.031 13.3 14.3 0.045 12.7 14.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.13 001277857.1_23523001_1 - 0.17 11.3 6.8 0.23 10.9 6.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit CTNNB1_binding PF08347.9 001277857.1_23523001_1 - 0.37 10.8 2.8 0.55 10.3 2.8 1.3 1 0 0 1 1 1 0 N-terminal CTNNB1 binding SPATA24 PF15175.4 001277857.1_23523001_1 - 0.39 10.5 17.7 0.2 11.4 14.2 1.9 1 1 1 2 2 2 0 Spermatogenesis-associated protein 24 FAM76 PF16046.3 001277857.1_23523001_1 - 0.72 9.0 13.9 1 8.5 13.9 1.2 1 0 0 1 1 1 0 FAM76 protein CorA PF01544.16 001277857.1_23523001_1 - 0.73 9.0 10.5 1.2 8.2 8.8 2.0 1 1 2 3 3 3 0 CorA-like Mg2+ transporter protein IncA PF04156.12 001277857.1_23523001_1 - 2.5 7.7 20.2 1.4 8.5 18.0 1.5 1 1 0 1 1 1 0 IncA protein BST2 PF16716.3 001277857.1_23523001_1 - 2.5 8.6 15.5 2.2 8.8 2.1 2.6 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 CREPT PF16566.3 001277857.1_23523001_1 - 2.8 7.9 11.7 6.4 6.8 11.4 1.6 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour TMPIT PF07851.11 001277857.1_23523001_1 - 3.6 6.6 13.9 3.9 6.5 13.2 1.3 1 1 0 1 1 1 0 TMPIT-like protein DUF342 PF03961.11 001277857.1_23523001_1 - 4.6 5.6 13.0 6.4 5.1 13.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) CENP-H PF05837.10 001277857.1_23523001_1 - 4.8 7.5 16.7 0.85 9.9 12.8 1.7 2 0 0 2 2 2 0 Centromere protein H (CENP-H) LMBR1 PF04791.14 001277857.1_23523001_1 - 5.2 5.7 9.9 6.9 5.3 9.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein AAA PF00004.27 001006225.1_23523001_1 - 1.7e-40 138.4 0.0 7.3e-40 136.3 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 001006225.1_23523001_1 - 7.5e-05 22.9 0.0 0.0061 16.7 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.12 001006225.1_23523001_1 - 0.00051 19.9 0.0 0.0025 17.7 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 001006225.1_23523001_1 - 0.0018 18.5 0.1 0.021 15.1 0.1 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.12 001006225.1_23523001_1 - 0.0041 17.1 0.0 0.013 15.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.11 001006225.1_23523001_1 - 0.0047 16.0 0.0 0.014 14.4 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_33 PF13671.4 001006225.1_23523001_1 - 0.014 15.4 0.0 0.027 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.10 001006225.1_23523001_1 - 0.015 14.4 0.0 0.03 13.5 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_18 PF13238.4 001006225.1_23523001_1 - 0.016 15.6 0.0 0.042 14.2 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.4 001006225.1_23523001_1 - 0.016 15.3 0.0 0.028 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.15 001006225.1_23523001_1 - 0.054 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.19 001006225.1_23523001_1 - 0.07 12.4 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.4 001006225.1_23523001_1 - 0.073 13.0 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain TIP49 PF06068.11 001006225.1_23523001_1 - 0.085 11.7 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AAA_24 PF13479.4 001006225.1_23523001_1 - 0.086 12.4 0.1 0.63 9.6 0.0 2.4 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.20 001006225.1_23523001_1 - 0.11 12.7 0.0 0.34 11.2 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.9 001006225.1_23523001_1 - 0.15 11.8 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Pkinase PF00069.23 001031126.2_23529001_1 - 5e-62 209.5 0.0 8.4e-62 208.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.20 001031126.2_23529001_1 - 2.5e-53 181.4 0.0 4.1e-53 180.6 0.0 1.4 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.15 001031126.2_23529001_1 - 1.2e-45 155.7 0.0 1.9e-45 155.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001031126.2_23529001_1 - 0.00053 19.2 0.0 0.0028 16.9 0.0 2.0 2 0 0 2 2 2 1 Kinase-like DUF1540 PF07561.9 001031126.2_23529001_1 - 0.053 13.7 1.1 0.18 12.1 1.1 1.9 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1540) Thymopoietin PF08198.9 001006235.1_23527001_1 - 2.9e-27 93.9 0.2 5.1e-27 93.1 0.2 1.4 1 0 0 1 1 1 1 Thymopoietin protein LEM PF03020.13 001006235.1_23527001_1 - 6e-20 70.4 1.2 1.2e-19 69.4 0.3 2.0 2 0 0 2 2 2 1 LEM domain eIF_4EBP PF05456.9 001006235.1_23527001_1 - 0.058 13.2 1.2 0.16 11.8 0.6 1.9 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Dynein_light PF01221.16 001277879.1_23522001_1 - 9.9e-43 144.2 1.9 9.9e-43 144.2 1.9 1.6 2 0 0 2 2 2 1 Dynein light chain type 1 Peptidase_C1 PF00112.21 001031129.1_23527001_1 - 1.4e-57 195.2 3.4 1.8e-57 194.8 3.4 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.13 001031129.1_23527001_1 - 3.4e-06 26.0 0.2 0.002 16.8 0.1 2.1 2 0 0 2 2 2 2 Peptidase C1-like family TMEM138 PF14935.4 001277895.1_23522001_2 - 2e-45 154.1 10.8 3.1e-45 153.5 10.8 1.3 1 0 0 1 1 1 1 Transmembrane protein 138 Bac_export_2 PF01312.17 001277895.1_23522001_2 - 0.78 8.8 3.2 1 8.4 3.2 1.1 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family CH_2 PF06294.9 001031138.2_23522001_2 - 6.3e-32 109.5 0.0 1.4e-31 108.3 0.0 1.6 2 0 0 2 2 2 1 CH-like domain in sperm protein CAMSAP_CH PF11971.6 001031138.2_23522001_2 - 5.5e-08 32.4 0.0 1.3e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain Glyco_transf_29 PF00777.16 204479.1_23525001_2 - 7.7e-65 218.8 0.0 1e-64 218.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Uso1_p115_head PF04869.12 001031139.1_23528001_1 - 2.3e-62 210.8 1.5 3.9e-62 210.0 0.0 2.1 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.11 001031139.1_23528001_1 - 2e-09 37.7 33.1 2e-09 37.7 33.1 4.4 1 1 2 3 3 1 1 Uso1 / p115 like vesicle tethering protein, C terminal region TMF_TATA_bd PF12325.6 001031139.1_23528001_1 - 0.0097 16.0 15.0 0.0097 16.0 15.0 4.3 1 1 0 3 3 3 2 TATA element modulatory factor 1 TATA binding BRE1 PF08647.9 001031139.1_23528001_1 - 0.01 15.7 7.9 0.01 15.7 7.9 5.1 4 1 0 4 4 4 0 BRE1 E3 ubiquitin ligase Atx10homo_assoc PF09759.7 001031139.1_23528001_1 - 0.048 13.6 10.7 0.4 10.6 0.4 4.5 4 0 0 4 4 4 0 Spinocerebellar ataxia type 10 protein domain TACC PF05010.12 001031139.1_23528001_1 - 0.23 11.1 48.5 0.014 15.0 26.3 3.5 1 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC) Mod_r PF07200.11 001031139.1_23528001_1 - 0.35 10.8 50.2 0.35 10.8 8.7 3.8 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein APG6 PF04111.10 001031139.1_23528001_1 - 1.8 7.8 51.9 0.089 12.0 15.6 3.4 1 1 2 4 4 4 0 Autophagy protein Apg6 Spc7 PF08317.9 001031139.1_23528001_1 - 1.9 7.1 54.8 12 4.5 17.9 3.6 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF4407 PF14362.4 001031139.1_23528001_1 - 2.3 7.4 37.1 4.6 6.4 16.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TMF_DNA_bd PF12329.6 001031139.1_23528001_1 - 6.8 6.6 56.9 0.55 10.1 2.8 6.1 4 1 1 5 5 5 0 TATA element modulatory factor 1 DNA binding HLH PF00010.24 204486.2_23525001_2 - 4.4e-10 39.2 1.1 9e-10 38.2 1.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.12 204486.2_23525001_2 - 0.17 10.0 8.7 0.23 9.6 8.7 1.1 1 0 0 1 1 1 0 CDC45-like protein LIM PF00412.20 001031149.1_23529001_3 - 1.4e-35 121.2 42.2 2e-13 50.2 4.3 4.7 4 0 0 4 4 4 3 LIM domain PDZ PF00595.22 001031149.1_23529001_3 - 2.2e-12 47.0 0.0 3.8e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) DUF4749 PF15936.3 001031149.1_23529001_3 - 3.7e-07 31.1 0.1 6.9e-07 30.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ_2 PF13180.4 001031149.1_23529001_3 - 0.052 13.7 0.0 0.099 12.8 0.0 1.3 1 0 0 1 1 1 0 PDZ domain RRM_1 PF00076.20 001277907.1_23523001_2 - 1.2e-13 50.5 0.0 1.9e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.4 001277907.1_23523001_2 - 3e-10 40.4 10.6 3e-10 40.4 10.6 4.3 3 1 0 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 FYTT PF07078.9 001277907.1_23523001_2 - 0.00019 20.8 0.0 0.00019 20.8 0.0 1.7 2 0 0 2 2 2 1 Forty-two-three protein Amidohydro_1 PF01979.18 204495.1_23526001_2 - 1.5e-32 113.2 0.0 1.9e-32 112.8 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 204495.1_23526001_2 - 4.6e-10 39.4 0.1 3.3e-07 30.0 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_2 PF04909.12 204495.1_23526001_2 - 0.045 13.4 0.0 0.089 12.4 0.0 1.5 1 0 0 1 1 1 0 Amidohydrolase EGF PF00008.25 204498.2_23523001_1 - 3.5e-15 55.8 75.1 0.00043 20.4 7.7 5.8 5 0 0 5 5 5 5 EGF-like domain EGF_2 PF07974.11 204498.2_23523001_1 - 2.2e-10 40.6 94.4 0.0052 17.0 13.2 5.9 6 0 0 6 6 6 5 EGF-like domain hEGF PF12661.5 204498.2_23523001_1 - 9.2e-06 26.0 85.6 0.00053 20.4 4.1 7.3 9 0 0 9 9 9 5 Human growth factor-like EGF Vps39_1 PF10366.7 001031194.1_23529001_2 - 3.9e-32 110.7 2.9 3.9e-32 110.7 2.9 2.7 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.7 001031194.1_23529001_2 - 1.3e-30 105.9 5.1 1.3e-30 105.9 5.1 2.7 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.20 001031194.1_23529001_2 - 2.3e-29 102.7 0.1 4.2e-29 101.9 0.1 1.4 1 0 0 1 1 1 1 CNH domain Clathrin PF00637.18 001031194.1_23529001_2 - 2.5e-12 46.7 10.2 1.9e-06 27.7 0.9 3.8 3 1 0 3 3 3 2 Region in Clathrin and VPS WD40_like PF17005.3 001031194.1_23529001_2 - 0.0054 16.0 0.6 0.016 14.4 0.1 1.9 2 0 0 2 2 2 1 WD40-like domain Pkinase PF00069.23 001031201.1_23529001_2 - 2.2e-61 207.4 0.0 3.5e-61 206.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001031201.1_23529001_2 - 1.1e-31 109.9 0.0 1.9e-31 109.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 001031201.1_23529001_2 - 2.8e-25 87.8 19.9 2.2e-14 52.9 7.9 4.3 6 0 0 6 6 6 2 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.27 001031201.1_23529001_2 - 2.1e-08 34.4 0.1 1.4e-07 31.9 0.1 2.4 2 0 0 2 2 2 1 PH domain Kinase-like PF14531.4 001031201.1_23529001_2 - 1.3e-05 24.6 0.0 2.6e-05 23.6 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.12 001031201.1_23529001_2 - 8.2e-05 21.9 0.0 0.00015 21.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001031201.1_23529001_2 - 0.16 11.7 0.1 0.95 9.2 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family C1_2 PF03107.14 001031201.1_23529001_2 - 0.83 9.9 31.9 0.019 15.2 6.2 3.9 4 0 0 4 4 4 0 C1 domain DNA_pol3_delta2 PF13177.4 001006276.1_23526001_2 - 1e-09 38.2 0.2 1.5e-09 37.7 0.2 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DNA_pol3_delta PF06144.11 001006276.1_23526001_2 - 1.8e-05 24.4 0.0 3.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.13 001006276.1_23526001_2 - 2.1e-05 23.5 0.0 2.9e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA PF00004.27 001006276.1_23526001_2 - 6e-05 23.3 0.0 0.0001 22.6 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 001006276.1_23526001_2 - 0.0076 16.5 0.1 0.015 15.6 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 001006276.1_23526001_2 - 0.026 14.7 0.1 0.054 13.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.25 001006276.1_23526001_2 - 0.065 13.6 0.0 0.11 12.9 0.0 1.2 1 0 0 1 1 1 0 ABC transporter E1_DerP2_DerF2 PF02221.13 001031203.1_23523001_2 - 3.4e-30 105.1 0.7 4.5e-30 104.7 0.7 1.2 1 0 0 1 1 1 1 ML domain MGC-24 PF05283.9 001006279.2_23526001_1 - 9.1e-06 26.0 10.1 9.1e-06 26.0 10.1 2.4 1 1 1 2 2 2 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF3377 PF11857.6 001006279.2_23526001_1 - 1.1 9.1 3.7 10 6.0 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) F-box-like PF12937.5 001031213.1_23527001_1 - 7.9e-05 22.3 0.0 0.0002 21.0 0.0 1.7 1 0 0 1 1 1 1 F-box-like BTK PF00779.17 001031213.1_23527001_1 - 0.00098 18.8 1.2 0.0032 17.1 1.2 1.9 1 0 0 1 1 1 1 BTK motif F-box PF00646.31 001031213.1_23527001_1 - 0.0094 15.7 0.4 0.034 13.9 0.0 2.1 2 0 0 2 2 2 1 F-box domain TH1 PF04858.11 001006294.1_23525001_3 - 5.5e-283 939.8 0.1 6.6e-283 939.5 0.1 1.0 1 0 0 1 1 1 1 TH1 protein 6PGD PF00393.17 001006303.1_23524001_3 - 1.5e-132 441.2 0.0 1.9e-132 440.9 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.13 001006303.1_23524001_3 - 4.4e-49 166.6 0.0 6.2e-49 166.1 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.4 001006303.1_23524001_3 - 0.0034 17.5 0.0 0.009 16.1 0.0 1.7 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.15 001006303.1_23524001_3 - 0.16 12.5 0.1 0.36 11.3 0.1 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Kinesin PF00225.21 001031230.1_23528001_2 - 9.1e-117 389.6 0.1 9.1e-117 389.6 0.1 3.2 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bind PF13931.4 001031230.1_23528001_2 - 7.8e-50 168.6 1.1 7.8e-50 168.6 1.1 5.0 3 2 1 5 5 5 1 Kinesin-associated microtubule-binding Microtub_bd PF16796.3 001031230.1_23528001_2 - 3e-24 85.5 0.1 3e-24 85.5 0.1 2.7 2 1 0 2 2 2 1 Microtubule binding zf-DHHC PF01529.18 001006310.2_23523001_1 - 5.2e-37 126.8 9.2 5.2e-37 126.8 9.2 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF4131 PF13567.4 001006310.2_23523001_1 - 0.025 14.0 3.4 2.8 7.4 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Entericidin PF08085.9 204558.1_23523001_1 - 0.028 14.3 1.5 0.028 14.3 1.5 2.4 2 0 0 2 2 2 0 Entericidin EcnA/B family IRF-3 PF10401.7 204558.1_23523001_2 - 4e-63 212.3 0.0 5.1e-63 212.0 0.0 1.1 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.15 204558.1_23523001_2 - 3e-43 146.2 0.7 4.5e-43 145.7 0.7 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor dNK PF01712.17 001031247.1_23527001_2 - 4e-32 111.6 0.0 5.7e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Deoxynucleoside kinase Thymidylate_kin PF02223.15 001031247.1_23527001_2 - 0.01 15.4 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 1 Thymidylate kinase SKI PF01202.20 001031247.1_23527001_2 - 0.019 15.0 0.1 0.44 10.5 0.0 2.2 2 0 0 2 2 2 0 Shikimate kinase Cytidylate_kin PF02224.16 001031247.1_23527001_2 - 0.18 11.4 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase DUF837 PF05769.9 001006324.2_23525001_1 - 7.6e-59 198.6 7.3 1.1e-58 198.0 7.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF837) DUF972 PF06156.11 001006324.2_23525001_1 - 4.2 7.9 5.7 1.6 9.3 0.6 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF972) TNF PF00229.16 204591.2_23523001_3 - 1.4e-38 131.6 0.1 3.1e-38 130.5 0.1 1.6 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family EF-hand_4 PF12763.5 001031283.1_23529001_2 - 3.8e-41 139.1 0.1 2.4e-23 82.0 0.0 3.7 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.30 001031283.1_23529001_2 - 7.6e-10 37.5 5.6 0.033 13.6 0.2 4.0 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 001031283.1_23529001_2 - 3.9e-05 23.9 1.9 0.052 13.9 0.2 4.3 2 2 2 4 4 4 1 EF-hand domain pair EF-hand_6 PF13405.4 001031283.1_23529001_2 - 6.4e-05 22.5 2.1 3.6 7.6 0.0 4.5 4 0 0 4 4 4 1 EF-hand domain EF-hand_8 PF13833.4 001031283.1_23529001_2 - 0.00016 21.2 1.3 0.092 12.4 0.4 2.8 2 0 0 2 2 2 2 EF-hand domain pair Spc7 PF08317.9 001031283.1_23529001_2 - 0.00072 18.4 24.0 0.00072 18.4 24.0 2.6 2 1 1 3 3 2 1 Spc7 kinetochore protein EF-hand_5 PF13202.4 001031283.1_23529001_2 - 0.0026 17.1 2.6 1 8.9 0.1 3.5 3 0 0 3 3 3 1 EF hand Reo_sigmaC PF04582.10 001031283.1_23529001_2 - 0.004 16.5 17.6 0.035 13.4 6.7 2.1 1 1 1 2 2 2 2 Reovirus sigma C capsid protein AAA_13 PF13166.4 001031283.1_23529001_2 - 0.11 11.0 29.0 1.1 7.7 28.4 2.2 1 1 0 1 1 1 0 AAA domain IncA PF04156.12 001031283.1_23529001_2 - 0.42 10.3 52.2 0.03 14.0 27.9 3.0 2 1 2 4 4 4 0 IncA protein Fib_alpha PF08702.8 001031283.1_23529001_2 - 0.77 9.8 25.8 0.29 11.2 9.6 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family UIM PF02809.18 001031283.1_23529001_2 - 0.8 9.6 6.2 0.85 9.6 3.6 2.5 2 0 0 2 2 2 0 Ubiquitin interaction motif DUF812 PF05667.9 001031283.1_23529001_2 - 1.2 7.8 38.0 1 8.0 35.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF812) ESSS PF10183.7 001031283.1_23529001_2 - 1.2 9.3 3.5 0.41 10.8 0.5 1.7 2 0 0 2 2 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Snapin_Pallidin PF14712.4 001031283.1_23529001_2 - 1.8 8.9 26.1 0.74 10.2 6.4 2.7 2 0 0 2 2 2 0 Snapin/Pallidin TMPIT PF07851.11 001031283.1_23529001_2 - 6.5 5.8 28.4 0.38 9.8 15.1 2.2 1 1 1 2 2 2 0 TMPIT-like protein Atg14 PF10186.7 001031283.1_23529001_2 - 7.1 5.5 34.0 25 3.7 16.4 2.6 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 FUSC PF04632.10 001031283.1_23529001_2 - 7.1 4.9 6.6 14 4.0 6.6 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family Ribosomal_L3 PF00297.20 001006366.1_23524001_2 - 6.2e-60 203.0 0.1 2.2e-42 145.2 0.9 3.1 1 1 2 3 3 3 3 Ribosomal protein L3 Homeobox PF00046.27 204616.1_23524001_1 - 3.1e-20 71.6 4.6 5.8e-20 70.7 4.6 1.4 1 0 0 1 1 1 1 Homeobox domain DUF4131 PF13567.4 204616.1_23524001_1 - 0.61 9.5 4.5 1.2 8.6 4.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) HemY_N PF07219.11 204616.1_23524001_1 - 1.4 9.0 6.9 0.95 9.5 0.1 2.6 2 1 0 2 2 2 0 HemY protein N-terminus adh_short PF00106.23 001277995.1_23523001_1 - 3.7e-42 143.9 0.0 5e-42 143.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001277995.1_23523001_1 - 1e-24 87.3 0.0 1.3e-24 86.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001277995.1_23523001_1 - 4.5e-07 29.8 0.0 6e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.8 001277995.1_23523001_1 - 0.0018 17.6 0.0 0.0048 16.2 0.0 1.7 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) DUF1118 PF06549.10 001277995.1_23523001_1 - 0.084 13.0 0.2 0.21 11.7 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1118) RecA PF00154.19 001277995.1_23523001_1 - 0.091 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein Lyase_1 PF00206.18 001006382.1_23524001_3 - 1.8e-122 408.5 0.1 2.5e-122 408.0 0.1 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.7 001006382.1_23524001_3 - 5.1e-28 97.1 0.1 2.2e-27 95.1 0.0 2.1 2 0 0 2 2 2 1 Fumarase C C-terminus Peptidase_M20 PF01546.26 001006385.1_23525001_1 - 1.2e-36 126.2 0.0 1.6e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.12 001006385.1_23525001_1 - 1.1e-15 57.4 0.0 3.1e-15 55.9 0.0 1.8 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.15 001006385.1_23525001_1 - 0.18 11.4 0.0 0.33 10.5 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 Methyltransf_15 PF09445.8 001006389.1_23526001_3 - 9.8e-45 152.1 0.0 1.7e-44 151.3 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.4 001006389.1_23526001_3 - 8.9e-08 32.6 0.0 2.7e-07 31.1 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.16 001006389.1_23526001_3 - 2e-07 30.7 0.0 1.4e-06 28.0 0.0 2.3 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Met_10 PF02475.14 001006389.1_23526001_3 - 3.7e-07 30.0 0.0 8.7e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_31 PF13847.4 001006389.1_23526001_3 - 1.3e-06 28.2 0.0 3.3e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001006389.1_23526001_3 - 0.00015 22.2 0.1 0.00066 20.1 0.1 2.1 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.12 001006389.1_23526001_3 - 0.0014 18.1 0.0 0.0026 17.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.11 001006389.1_23526001_3 - 0.002 17.4 0.3 0.0049 16.2 0.3 1.6 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) ADH_zinc_N PF00107.24 001006389.1_23526001_3 - 0.0059 16.4 0.1 0.012 15.4 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_18 PF12847.5 001006389.1_23526001_3 - 0.0079 16.0 0.0 0.023 14.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain BRD4_CDT PF17105.3 001006389.1_23526001_3 - 0.024 14.1 0.3 0.053 13.0 0.3 1.6 1 0 0 1 1 1 0 C-terminal domain of bromodomain protein 4 MethyltransfD12 PF02086.13 001006389.1_23526001_3 - 0.27 10.7 2.0 1.3 8.5 0.1 2.9 2 1 1 3 3 3 0 D12 class N6 adenine-specific DNA methyltransferase Myosin_head PF00063.19 001001302.1_23529001_1 - 6.3e-293 973.0 1.1 6.3e-293 973.0 1.1 2.9 2 1 1 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 001001302.1_23529001_1 - 2.5e-161 538.7 280.2 3.1e-161 538.4 280.2 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 001001302.1_23529001_1 - 4.3e-09 35.9 0.0 1.1e-08 34.6 0.0 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 001001302.1_23529001_1 - 0.0048 16.2 78.4 0.15 11.3 5.3 9.0 2 2 10 12 12 12 8 Reovirus sigma C capsid protein IQ PF00612.25 001001302.1_23529001_1 - 0.041 13.6 2.5 0.36 10.6 0.9 2.7 2 0 0 2 2 2 0 IQ calmodulin-binding motif AAA_22 PF13401.4 001001302.1_23529001_1 - 0.06 13.5 0.0 0.06 13.5 0.0 6.3 4 2 2 6 6 6 0 AAA domain ATP-synt_ab PF00006.23 001001302.1_23529001_1 - 0.11 12.0 0.1 0.31 10.5 0.1 1.7 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_16 PF13191.4 001001302.1_23529001_1 - 0.11 12.7 0.0 0.11 12.7 0.0 6.4 2 1 1 4 4 4 0 AAA ATPase domain GTSE1_N PF15259.4 001031332.1_23526001_1 - 6.6e-53 178.7 1.7 6.6e-53 178.7 1.7 2.4 2 0 0 2 2 2 1 G-2 and S-phase expressed 1 AAA_18 PF13238.4 001031333.1_23527001_1 - 1e-26 93.8 0.0 1.5e-26 93.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.4 001031333.1_23527001_1 - 1.2e-06 28.8 0.0 1.9e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 001031333.1_23527001_1 - 0.0022 18.2 0.0 0.0041 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.4 001031333.1_23527001_1 - 0.0036 17.4 0.0 0.0055 16.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA PF00004.27 001031333.1_23527001_1 - 0.007 16.7 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 001031333.1_23527001_1 - 0.016 15.4 0.0 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.12 001031333.1_23527001_1 - 0.028 14.3 0.0 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ADK PF00406.20 001031333.1_23527001_1 - 0.041 13.9 0.0 0.069 13.1 0.0 1.3 1 0 0 1 1 1 0 Adenylate kinase SKI PF01202.20 001031333.1_23527001_1 - 0.057 13.4 0.5 0.17 11.9 0.5 1.8 1 1 0 1 1 1 0 Shikimate kinase AAA_29 PF13555.4 001031333.1_23527001_1 - 0.075 12.6 0.4 0.29 10.8 0.1 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_33 PF13671.4 001031333.1_23527001_1 - 0.076 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.13 001031333.1_23527001_1 - 0.14 12.0 0.1 0.21 11.3 0.1 1.3 1 0 0 1 1 1 0 NTPase AAA_24 PF13479.4 001031333.1_23527001_1 - 0.17 11.5 0.1 0.64 9.6 0.1 1.8 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.16 001031333.1_23527001_1 - 0.22 11.1 0.0 0.3 10.7 0.0 1.1 1 0 0 1 1 1 0 Cytidylate kinase ATPase PF06745.11 001031333.1_23527001_1 - 0.25 10.5 0.0 0.43 9.8 0.0 1.2 1 0 0 1 1 1 0 KaiC Ribosomal_S16 PF00886.17 001278026.1_23523001_1 - 6.2e-20 70.8 0.0 1.1e-19 70.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S16 Ribosomal_S16 PF00886.17 001278027.1_23522001_1 - 3.5e-20 71.6 0.0 5.7e-20 71.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S16 V-set PF07686.15 204649.1_23524001_2 - 2.1e-15 56.7 3.7 3.5e-07 30.2 0.2 4.2 3 1 1 4 4 4 3 Immunoglobulin V-set domain Tcell_CD4_C PF12104.6 204649.1_23524001_2 - 2.6e-15 55.9 15.8 5.6e-15 54.8 15.8 1.6 1 0 0 1 1 1 1 T cell CD4 receptor C terminal region Ig_3 PF13927.4 204649.1_23524001_2 - 3.6e-15 56.2 2.8 1.2e-06 28.8 0.1 4.5 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.23 204649.1_23524001_2 - 1.4e-10 41.0 3.1 0.0027 17.7 0.2 4.6 4 1 0 4 4 4 3 Immunoglobulin domain I-set PF07679.14 204649.1_23524001_2 - 6.7e-09 35.6 1.1 0.0028 17.5 0.1 4.1 4 0 0 4 4 4 2 Immunoglobulin I-set domain Ig_2 PF13895.4 204649.1_23524001_2 - 2.7e-07 30.7 5.5 0.011 15.9 0.5 4.7 3 2 1 4 4 4 2 Immunoglobulin domain Izumo-Ig PF16706.3 204649.1_23524001_2 - 2.5e-06 27.3 0.9 1.6 8.7 0.0 4.9 5 0 0 5 5 5 2 Izumo-like Immunoglobulin domain CD4-extracel PF09191.8 204649.1_23524001_2 - 1.3e-05 25.4 0.4 0.00013 22.2 0.1 2.5 2 0 0 2 2 2 1 CD4, extracellular C2-set PF05790.13 204649.1_23524001_2 - 0.00024 21.1 5.8 1.2 9.2 0.5 5.3 4 1 0 4 4 4 1 Immunoglobulin C2-set domain DUF2479 PF10651.7 204649.1_23524001_2 - 0.0023 17.5 0.1 0.016 14.8 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF2479) DUF1049 PF06305.9 204649.1_23524001_2 - 0.0096 15.6 1.1 0.029 14.1 0.1 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF1049) DUF1191 PF06697.10 204649.1_23524001_2 - 0.027 13.6 0.3 0.053 12.6 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) C1-set PF07654.13 204649.1_23524001_2 - 0.039 14.3 0.2 0.51 10.7 0.0 2.9 3 0 0 3 3 3 0 Immunoglobulin C1-set domain IL12p40_C PF10420.7 204649.1_23524001_2 - 0.074 13.4 1.2 1.1 9.7 0.6 2.7 2 0 0 2 2 2 0 Cytokine interleukin-12p40 C-terminus Neurensin PF14927.4 204649.1_23524001_2 - 0.14 11.8 0.3 1.4 8.5 0.0 2.3 2 0 0 2 2 2 0 Neurensin DUF3129 PF11327.6 204649.1_23524001_2 - 0.15 12.3 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3129) Herpes_gE PF02480.14 204649.1_23524001_2 - 0.19 10.3 5.3 13 4.2 3.7 3.2 2 2 1 3 3 3 0 Alphaherpesvirus glycoprotein E EphA2_TM PF14575.4 204649.1_23524001_2 - 0.69 10.6 2.5 0.93 10.2 0.7 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Ig_4 PF16680.3 204649.1_23524001_2 - 1.4 9.2 10.6 6.9 7.0 0.0 4.7 5 1 1 6 6 5 0 T-cell surface glycoprotein CD3 delta chain GBP PF02263.17 204652.1_23524001_1 - 6.6e-109 363.0 0.0 1.2e-108 362.2 0.0 1.4 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.12 204652.1_23524001_1 - 3.3e-96 322.0 19.5 4.6e-96 321.6 19.5 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain MMR_HSR1 PF01926.21 204652.1_23524001_1 - 0.11 12.5 0.1 0.46 10.5 0.0 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_14 PF13173.4 204652.1_23524001_1 - 0.15 12.0 0.0 0.5 10.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain Leu_zip PF15294.4 204652.1_23524001_1 - 1.2 8.4 17.2 1.8 7.9 16.9 1.4 1 1 0 1 1 1 0 Leucine zipper Cpn60_TCP1 PF00118.22 001006405.1_23524001_1 - 1.4e-154 515.3 15.3 1.6e-154 515.1 15.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family 2-oxoacid_dh PF00198.21 204656.1_23524001_3 - 1.2e-78 263.6 0.0 1.8e-78 263.1 0.0 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.20 204656.1_23524001_3 - 1.6e-18 66.2 0.1 2.7e-18 65.4 0.1 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.15 204656.1_23524001_3 - 2e-14 53.5 0.0 4.5e-14 52.4 0.0 1.7 1 0 0 1 1 1 1 e3 binding domain Sec1 PF00995.21 001031348.1_23525001_2 - 1.4e-95 321.5 0.0 1.6e-95 321.3 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Peptidase_S9_N PF02897.13 001006410.1_23526001_3 - 4.1e-160 533.0 0.0 5e-160 532.7 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.19 001006410.1_23526001_3 - 8.6e-67 224.6 0.0 1.3e-66 224.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.18 001006410.1_23526001_3 - 0.064 12.8 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Putative esterase ANP PF00212.16 001193616.1_23521001_2 - 1.3e-12 47.5 0.4 2.8e-12 46.4 0.4 1.6 1 0 0 1 1 1 1 Atrial natriuretic peptide RRM_1 PF00076.20 001006427.2_23527001_2 - 2.1e-05 24.1 0.1 4.4e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MTS PF05175.12 001278078.1_23523001_2 - 8.3e-09 35.1 0.0 7.8e-08 31.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.11 001278078.1_23523001_2 - 0.00027 20.3 0.0 0.00074 18.9 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.17 001278078.1_23523001_2 - 0.023 14.3 0.0 0.036 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.4 001278078.1_23523001_2 - 0.041 14.5 0.0 0.083 13.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.4 001278078.1_23523001_2 - 0.066 14.1 0.0 0.17 12.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.7 001278078.1_23523001_2 - 0.093 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_12 PF08242.10 001278078.1_23523001_2 - 0.13 12.9 0.0 0.32 11.6 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.10 001278083.1_23523001_1 - 1.7e-21 76.5 0.0 2.8e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001278083.1_23523001_1 - 4.8e-16 59.0 0.0 6.9e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 001278083.1_23523001_1 - 7e-16 58.6 0.0 1.2e-15 57.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001278083.1_23523001_1 - 5.7e-11 42.3 0.0 1.8e-10 40.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001278083.1_23523001_1 - 5.7e-10 39.7 0.0 9.7e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 001278083.1_23523001_1 - 6e-09 35.4 0.0 9.3e-09 34.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.14 001278083.1_23523001_1 - 0.00022 19.8 0.0 0.0003 19.4 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.12 001278083.1_23523001_1 - 0.032 13.7 0.0 0.047 13.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_8 PF05148.13 001278083.1_23523001_1 - 0.037 13.7 0.0 0.064 13.0 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_7 PF03492.13 001278083.1_23523001_1 - 0.053 12.6 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase MetW PF07021.10 001278083.1_23523001_1 - 0.15 11.5 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Pkinase PF00069.23 001031378.1_23527001_3 - 1.6e-47 161.9 0.0 4.7e-47 160.4 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001031378.1_23527001_3 - 3.4e-34 118.2 0.2 1.3e-25 90.0 0.0 2.4 1 1 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.12 001031378.1_23527001_3 - 0.0012 18.1 0.0 0.0022 17.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001031378.1_23527001_3 - 0.0023 17.8 0.0 0.043 13.6 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.20 001031378.1_23527001_3 - 0.076 12.5 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Asparaginase_2 PF01112.16 001006445.1_23526001_1 - 7.2e-82 274.7 0.6 1e-81 274.2 0.6 1.1 1 0 0 1 1 1 1 Asparaginase Sec7 PF01369.18 001006446.1_23524001_3 - 8e-36 123.4 0.1 1.2e-35 122.8 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain F-box-like PF12937.5 001006446.1_23524001_3 - 7.2e-07 28.9 0.5 1.8e-06 27.6 0.5 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001006446.1_23524001_3 - 0.015 15.1 0.2 0.015 15.1 0.2 2.3 3 0 0 3 3 3 0 F-box domain RFC1 PF08519.10 001006456.1_23528001_3 - 6.6e-59 198.4 0.0 1.8e-58 197.0 0.0 1.8 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain BRCT PF00533.24 001006456.1_23528001_3 - 2.5e-17 62.9 0.0 9.5e-17 61.1 0.0 2.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.27 001006456.1_23528001_3 - 3.8e-15 56.3 0.0 8.8e-15 55.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PTCB-BRCT PF12738.5 001006456.1_23528001_3 - 4.3e-07 29.6 0.1 1.1e-06 28.3 0.1 1.8 1 0 0 1 1 1 1 twin BRCT domain AAA_14 PF13173.4 001006456.1_23528001_3 - 0.00033 20.5 0.1 0.0011 18.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.12 001006456.1_23528001_3 - 0.0004 20.2 0.2 0.0011 18.8 0.0 1.8 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.20 001006456.1_23528001_3 - 0.0007 19.8 0.1 0.0052 17.0 0.0 2.6 2 1 0 2 2 2 1 RNA helicase RuvB_N PF05496.10 001006456.1_23528001_3 - 0.0011 18.2 0.0 0.0023 17.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.4 001006456.1_23528001_3 - 0.0011 19.1 0.0 0.0057 16.8 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 001006456.1_23528001_3 - 0.0012 18.9 0.0 0.0036 17.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 001006456.1_23528001_3 - 0.0013 19.0 0.0 0.004 17.4 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain BRCT_2 PF16589.3 001006456.1_23528001_3 - 0.0042 17.3 0.0 0.017 15.4 0.0 2.1 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain AAA_18 PF13238.4 001006456.1_23528001_3 - 0.0051 17.2 1.0 0.015 15.6 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 001006456.1_23528001_3 - 0.011 15.3 0.0 0.031 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.4 001006456.1_23528001_3 - 0.017 15.4 1.4 0.048 14.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.13 001006456.1_23528001_3 - 0.047 13.5 0.1 0.15 11.8 0.1 1.9 1 1 1 2 2 2 0 NTPase Pkinase PF00069.23 001006459.1_23525001_1 - 1.7e-63 214.3 0.0 2.3e-63 213.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001006459.1_23525001_1 - 1.1e-33 116.5 0.0 1.7e-33 115.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.17 001006459.1_23525001_1 - 2.4e-21 76.0 0.1 4.9e-21 75.1 0.1 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain Kinase-like PF14531.4 001006459.1_23525001_1 - 4.5e-05 22.8 0.0 7.4e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like EF-hand_7 PF13499.4 001006468.1_23525001_3 - 7.3e-10 39.1 4.2 7.3e-10 39.1 4.2 3.6 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.30 001006468.1_23525001_3 - 2.3e-07 29.7 2.6 0.012 15.0 0.4 3.3 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 001006468.1_23525001_3 - 1.5e-05 24.5 1.5 0.0012 18.5 0.6 3.1 2 0 0 2 2 2 1 EF-hand domain FlxA PF14282.4 001006468.1_23525001_3 - 1.2 9.1 23.6 4.9 7.1 23.6 2.0 1 0 0 1 1 1 0 FlxA-like protein OmpH PF03938.12 001006468.1_23525001_3 - 1.7 8.5 36.8 0.039 13.8 24.0 2.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) MctB PF11382.6 001006468.1_23525001_3 - 8.1 5.9 9.2 14 5.2 9.2 1.3 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB TSSC4 PF15264.4 001006470.1_23525001_2 - 6.4e-28 97.4 0.1 1e-27 96.7 0.1 1.3 1 0 0 1 1 1 1 Tumour suppressing sub-chromosomal transferable candidate 4 KIAA1328 PF15369.4 001031404.1_23529001_1 - 1.1e-150 501.9 37.6 1.4e-150 501.5 37.6 1.1 1 0 0 1 1 1 1 Uncharacterised protein KIAA1328 ERM PF00769.17 001031404.1_23529001_1 - 0.0052 16.5 14.0 0.0052 16.5 14.0 2.1 2 0 0 2 2 2 1 Ezrin/radixin/moesin family SpoIISA_toxin PF14171.4 001031404.1_23529001_1 - 0.48 10.0 3.4 0.89 9.1 3.4 1.3 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system APG6 PF04111.10 001031404.1_23529001_1 - 3.3 6.9 22.8 4.8 6.4 13.5 2.1 2 0 0 2 2 2 0 Autophagy protein Apg6 Borrelia_rep PF03183.11 001006481.1_23523001_1 - 4.1 7.4 5.9 7.1 6.7 5.9 1.3 1 0 0 1 1 1 0 Borrelia repeat protein IF-2B PF01008.15 001006481.1_23523001_2 - 5.4e-83 278.3 0.0 6.9e-83 278.0 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family EMP24_GP25L PF01105.22 001006482.1_23525001_1 - 4.6e-45 153.7 0.0 5.7e-45 153.3 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD ParA PF10609.7 001198641.1_23523001_2 - 6.1e-102 340.1 0.1 7.1e-102 339.9 0.1 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.21 001198641.1_23523001_2 - 5.8e-11 42.4 0.0 2.1e-10 40.6 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.4 001198641.1_23523001_2 - 4.5e-09 36.3 0.2 8.2e-08 32.2 0.2 2.1 1 1 0 1 1 1 1 AAA domain Fer4_NifH PF00142.16 001198641.1_23523001_2 - 3e-06 26.8 0.1 0.05 12.9 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.13 001198641.1_23523001_2 - 3.3e-06 26.4 1.5 7.5e-05 22.0 0.1 2.6 2 1 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.9 001198641.1_23523001_2 - 0.00028 20.1 0.1 0.00093 18.4 0.1 1.8 1 1 0 1 1 1 1 ATPase MipZ DUF258 PF03193.14 001198641.1_23523001_2 - 0.00037 20.3 0.1 0.02 14.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 CLP1_P PF16575.3 001198641.1_23523001_2 - 0.00099 18.8 0.0 0.0091 15.7 0.0 2.2 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_25 PF13481.4 001198641.1_23523001_2 - 0.0028 17.1 0.1 0.0056 16.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_26 PF13500.4 001198641.1_23523001_2 - 0.0059 16.3 0.3 0.88 9.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain PcrB PF01884.15 001198641.1_23523001_2 - 0.026 13.9 0.0 0.04 13.3 0.0 1.2 1 0 0 1 1 1 0 PcrB family KAP_NTPase PF07693.12 001198641.1_23523001_2 - 0.037 13.1 0.0 0.042 13.0 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain TF_Zn_Ribbon PF08271.10 001198641.1_23523001_2 - 0.045 13.1 0.1 0.1 12.0 0.1 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding NACHT PF05729.10 001198641.1_23523001_2 - 0.059 13.2 0.1 0.096 12.5 0.1 1.3 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.15 001198641.1_23523001_2 - 0.064 13.1 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ArgK PF03308.14 001198641.1_23523001_2 - 0.079 11.8 0.1 0.12 11.2 0.1 1.2 1 0 0 1 1 1 0 ArgK protein DUF87 PF01935.15 001198641.1_23523001_2 - 0.14 12.0 0.4 0.23 11.3 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF87 SRP54 PF00448.20 001198641.1_23523001_2 - 0.17 11.4 0.1 0.39 10.2 0.0 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain APS_kinase PF01583.18 001198641.1_23523001_2 - 0.17 11.6 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase Zeta_toxin PF06414.10 001198641.1_23523001_2 - 0.21 10.7 0.0 0.36 10.0 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Rad51 PF08423.9 001198646.1_23523001_3 - 3.4e-23 82.1 0.0 4.6e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.4 001198646.1_23523001_3 - 1.4e-12 47.5 0.0 2.2e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.13 001198646.1_23523001_3 - 1.1e-10 41.1 0.2 3.6e-10 39.5 0.2 1.7 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.11 001198646.1_23523001_3 - 1.7e-06 27.4 0.2 9.7e-06 25.0 0.2 2.0 1 1 0 1 1 1 1 KaiC PSY3 PF16836.3 001198646.1_23523001_3 - 0.00026 20.5 0.1 0.00039 19.9 0.1 1.2 1 0 0 1 1 1 1 Shu complex component Psy3, DNA-binding description AAA PF00004.27 001198646.1_23523001_3 - 0.00064 20.0 0.0 0.0021 18.3 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 001198646.1_23523001_3 - 0.0043 17.2 0.1 0.0089 16.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain RecA PF00154.19 001198646.1_23523001_3 - 0.005 16.2 0.4 0.039 13.3 0.0 2.0 2 0 0 2 2 2 1 recA bacterial DNA recombination protein CbiA PF01656.21 001198646.1_23523001_3 - 0.022 14.7 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_18 PF13238.4 001198646.1_23523001_3 - 0.025 15.0 0.0 0.05 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.4 001198646.1_23523001_3 - 0.12 12.0 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain PAXNEB PF05625.9 001198646.1_23523001_3 - 0.17 10.9 0.3 1.8 7.5 0.0 2.0 2 0 0 2 2 2 0 PAXNEB protein Perilipin PF03036.14 001031420.1_23525001_3 - 3.3e-169 563.0 15.4 3.8e-169 562.7 15.4 1.0 1 0 0 1 1 1 1 Perilipin family SH3BP5 PF05276.12 001031420.1_23525001_3 - 0.015 15.0 3.5 0.027 14.1 2.3 2.0 2 0 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) Syntaxin-6_N PF09177.9 001031420.1_23525001_3 - 0.21 12.0 6.6 2.9 8.4 0.9 2.9 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Snapin_Pallidin PF14712.4 001031420.1_23525001_3 - 1.1 9.6 4.8 5.9 7.3 2.3 2.5 2 0 0 2 2 2 0 Snapin/Pallidin Glyco_hydro_39 PF01229.15 001031433.1_23529001_2 - 5.2e-153 510.0 0.0 6.9e-153 509.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 39 ARA70 PF12489.6 001006495.1_23528001_1 - 1.7e-64 215.8 37.1 3.1e-39 134.1 3.7 6.2 2 1 4 6 6 6 3 Nuclear coactivator BRK PF07533.14 001006495.1_23528001_1 - 0.031 13.8 3.1 2.6 7.6 0.2 2.8 2 0 0 2 2 2 0 BRK domain DTW PF03942.13 001031442.1_23529001_2 - 7.6e-42 143.1 0.4 1.1e-41 142.7 0.4 1.2 1 0 0 1 1 1 1 DTW domain CoA_transf_3 PF02515.15 001031448.1_23524001_2 - 1.7e-77 260.9 0.0 2.2e-77 260.5 0.0 1.2 1 0 0 1 1 1 1 CoA-transferase family III ANP PF00212.16 001198747.1_23522001_3 - 1.6e-09 37.6 2.6 2.8e-09 36.9 2.6 1.4 1 0 0 1 1 1 1 Atrial natriuretic peptide Cupin_8 PF13621.4 001278726.1_23523001_3 - 6.4e-13 49.0 0.1 1.4e-10 41.3 0.2 2.1 2 0 0 2 2 2 2 Cupin-like domain Cupin_4 PF08007.10 001278726.1_23523001_3 - 3.3e-06 26.7 0.8 2.4e-05 23.8 0.3 2.0 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.20 001278726.1_23523001_3 - 0.0031 17.8 0.0 0.01 16.2 0.0 1.7 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.9 001278726.1_23523001_3 - 0.03 13.9 1.0 0.18 11.4 0.2 2.5 2 1 0 2 2 2 0 Cupin domain Cupin_1 PF00190.20 001278726.1_23523001_3 - 0.052 13.0 0.0 0.17 11.4 0.0 1.9 1 1 0 1 1 1 0 Cupin Herpes_ORF11 PF04797.11 001278726.1_23523001_3 - 0.08 11.6 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus dUTPase protein SQHop_cyclase_C PF13243.4 001006514.2_23527001_3 - 1.6e-57 194.9 0.0 8.1e-52 176.2 0.0 2.3 2 0 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.4 001006514.2_23527001_3 - 8.4e-48 162.8 0.2 7.5e-43 146.6 0.0 3.9 3 1 2 5 5 5 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.19 001006514.2_23527001_3 - 9.3e-40 133.9 5.7 5.3e-11 41.9 1.5 5.7 5 0 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.8 001006514.2_23527001_3 - 0.00078 18.7 0.2 2.3 7.3 0.0 3.9 4 1 1 5 5 5 1 Pectic acid lyase A2M_comp PF07678.12 001006514.2_23527001_3 - 0.007 15.7 0.6 0.36 10.1 0.3 3.0 3 1 0 3 3 3 1 A-macroglobulin complement component Tmemb_18A PF09771.7 001198857.2_23524001_2 - 2.8e-57 192.1 0.0 5.1e-57 191.2 0.0 1.4 1 0 0 1 1 1 1 Transmembrane protein 188 tRNA-synt_2 PF00152.18 001006528.2_23525001_1 - 5.7e-78 262.0 0.1 8e-78 261.5 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.23 001006528.2_23525001_1 - 8e-10 38.5 1.0 1.5e-09 37.6 1.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.18 001006528.2_23525001_1 - 0.00028 20.3 0.3 0.75 9.1 0.2 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA_anti_2 PF13742.4 001006528.2_23525001_1 - 0.013 15.5 0.4 0.044 13.8 0.2 1.9 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain S-AdoMet_synt_N PF00438.18 001006528.2_23525001_1 - 0.028 15.0 0.2 0.13 12.8 0.2 2.0 2 0 0 2 2 2 0 S-adenosylmethionine synthetase, N-terminal domain Ribosomal_L34e PF01199.16 001281500.1_23521001_1 - 1.4e-42 143.7 8.2 2e-42 143.2 8.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L34e WD40 PF00400.30 001006536.1_23524001_2 - 2.7e-24 84.8 21.8 2.4e-06 28.0 0.2 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001006536.1_23524001_2 - 1.8e-18 66.5 10.1 2.9e-07 30.6 0.8 4.9 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001006536.1_23524001_2 - 0.00086 18.2 2.5 0.047 12.5 0.5 3.3 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 001006536.1_23524001_2 - 0.0071 14.9 3.9 0.61 8.5 0.2 2.8 3 1 1 4 4 4 2 Nucleoporin Nup120/160 Sds3 PF08598.9 001031471.1_23526001_2 - 1.7e-19 70.6 10.6 2.8e-19 69.9 10.6 1.3 1 0 0 1 1 1 1 Sds3-like Exonuc_VII_L PF02601.13 001031471.1_23526001_2 - 7.1 6.0 9.3 10 5.4 9.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit 7tm_1 PF00001.19 001031479.1_23523001_1 - 1.9e-43 148.5 23.9 2.3e-43 148.2 23.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001031479.1_23523001_1 - 0.00086 18.6 24.2 0.0016 17.7 24.2 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF543 PF04418.10 001031479.1_23523001_1 - 0.048 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF543) SPC25 PF06703.9 001031479.1_23523001_1 - 1 9.0 5.3 0.52 9.9 2.2 2.0 1 1 1 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) NDUF_B5 PF09781.7 001006553.1_23522001_2 - 6e-87 289.9 0.0 6.9e-87 289.7 0.0 1.0 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit Ribosomal_L22 PF00237.17 001282277.1_23522001_1 - 9.8e-43 144.7 0.1 1.6e-42 144.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Exo_endo_phos PF03372.21 001282294.1_23529001_3 - 6.7e-06 26.2 0.0 1.2e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CALCOCO1 PF07888.9 001282294.1_23529001_3 - 0.00012 20.7 0.4 0.00017 20.2 0.4 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4528 PF15031.4 001282329.1_23523001_1 - 2.9e-62 208.2 0.0 4.4e-62 207.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4528) Glyoxalase PF00903.23 001282341.1_23524001_1 - 7.3e-08 32.5 0.0 0.0023 18.0 0.0 3.0 3 0 0 3 3 3 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.4 001282341.1_23524001_1 - 0.01 16.0 0.0 0.71 10.1 0.0 2.6 2 1 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Ski_Sno PF02437.15 204795.1_23524001_1 - 1.6e-37 127.4 0.1 3.9e-37 126.2 0.1 1.6 1 0 0 1 1 1 1 SKI/SNO/DAC family DDE_Tnp_1_6 PF13751.4 204795.1_23524001_1 - 0.34 11.0 5.0 0.67 10.1 5.0 1.4 1 0 0 1 1 1 0 Transposase DDE domain LMBR1 PF04791.14 204795.1_23524001_1 - 0.75 8.5 2.6 0.95 8.1 2.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4778 PF16008.3 204795.1_23524001_1 - 2.5 7.9 9.4 4.7 7.0 9.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) Aminotran_3 PF00202.19 001006567.1_23525001_1 - 2.8e-121 404.9 0.0 3.4e-121 404.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.19 001006567.1_23525001_1 - 0.14 11.2 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II SP_C-Propep PF08999.8 001031492.1_23523001_1 - 0.063 12.9 1.0 0.15 11.7 1.0 1.6 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Meis_PKNOX_N PF16493.3 204803.1_23523001_1 - 2.6e-44 149.3 0.2 3.9e-44 148.8 0.2 1.2 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.9 204803.1_23523001_1 - 8.1e-21 73.5 1.0 1.4e-20 72.7 1.0 1.4 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 204803.1_23523001_1 - 2.5e-08 33.5 0.9 4.6e-08 32.6 0.5 1.6 2 0 0 2 2 2 1 Homeobox domain Biopterin_H PF00351.19 204805.2_23524001_2 - 1.6e-177 589.4 0.4 2e-177 589.0 0.4 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase TOH_N PF12549.6 204805.2_23524001_2 - 6.6e-22 76.6 1.3 4.5e-12 45.3 0.3 2.7 2 0 0 2 2 2 2 Tyrosine hydroxylase N terminal Pkinase PF00069.23 001031509.1_23525001_1 - 2.8e-72 243.1 0.0 5.8e-72 242.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 001031509.1_23525001_1 - 3.6e-39 134.5 0.0 5.5e-39 133.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.17 001031509.1_23525001_1 - 2.4e-13 49.5 0.1 4.8e-13 48.5 0.1 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.4 001031509.1_23525001_1 - 3.2e-07 29.8 0.0 5.2e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001031509.1_23525001_1 - 3.1e-05 23.3 0.0 8.9e-05 21.8 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001031509.1_23525001_1 - 0.0042 16.9 0.0 0.015 15.1 0.1 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.18 001031509.1_23525001_1 - 0.017 14.6 0.0 0.043 13.3 0.0 1.7 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.20 001031509.1_23525001_1 - 0.076 12.5 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 RIO1 family PFK PF00365.18 001031511.1_23527001_1 - 7.9e-159 527.2 8.0 1.5e-111 372.1 1.4 2.1 2 0 0 2 2 2 2 Phosphofructokinase PFK PF00365.18 001031511.1_23527001_3 - 1.9e-58 197.9 0.0 2.5e-58 197.5 0.0 1.1 1 0 0 1 1 1 1 Phosphofructokinase Ribosomal_L4 PF00573.20 001007479.1_23523001_2 - 2.1e-39 135.0 0.1 2.1e-39 135.0 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.4 001007479.1_23523001_2 - 3.3e-31 107.0 7.2 3.3e-31 107.0 7.2 2.0 1 1 0 1 1 1 1 60S ribosomal protein L4 C-terminal domain HLH PF00010.24 001007485.1_23522001_1 - 2.9e-18 65.5 0.2 5.2e-18 64.6 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Rootletin PF15035.4 001007485.1_23522001_1 - 0.00015 21.8 3.2 0.00025 21.1 3.2 1.4 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion HALZ PF02183.16 001007485.1_23522001_1 - 0.27 11.3 7.9 0.22 11.6 1.7 2.3 1 1 1 2 2 2 0 Homeobox associated leucine zipper FlxA PF14282.4 001007485.1_23522001_1 - 3.2 7.7 10.1 0.56 10.1 5.4 2.2 2 0 0 2 2 2 0 FlxA-like protein ZapB PF06005.10 001007485.1_23522001_1 - 3.6 8.0 13.5 2.6 8.4 7.1 2.7 2 1 0 2 2 2 0 Cell division protein ZapB Snapin_Pallidin PF14712.4 001007825.1_23525001_3 - 4.5e-23 81.4 6.2 8e-23 80.6 6.2 1.4 1 0 0 1 1 1 1 Snapin/Pallidin TCP PF03634.11 001007825.1_23525001_3 - 0.31 11.4 7.4 0.45 10.9 7.4 1.1 1 0 0 1 1 1 0 TCP family transcription factor UPF0258 PF06789.10 001007827.2_23528001_3 - 1e-68 230.5 0.1 2.5e-68 229.2 0.1 1.7 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0258) RXT2_N PF08595.9 001007827.2_23528001_3 - 0.02 14.8 0.4 0.02 14.8 0.4 1.9 2 0 0 2 2 2 0 RXT2-like, N-terminal TANGO2 PF05742.10 001007836.1_23527001_1 - 5.2e-75 252.6 0.0 6.9e-75 252.2 0.0 1.1 1 0 0 1 1 1 1 Transport and Golgi organisation 2 RP-C_C PF11800.6 001199478.1_23522001_1 - 0.017 15.0 0.9 0.025 14.5 0.9 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF4407 PF14362.4 001199478.1_23522001_1 - 0.03 13.5 0.5 0.04 13.1 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BUD22 PF09073.8 001199478.1_23522001_1 - 0.031 13.5 3.8 0.039 13.2 3.8 1.1 1 0 0 1 1 1 0 BUD22 Golgin_A5 PF09787.7 001199478.1_23522001_1 - 0.06 12.7 3.9 0.082 12.2 3.9 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 SKA2 PF16740.3 001199478.1_23522001_1 - 0.066 12.9 3.8 0.099 12.3 3.8 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 XhlA PF10779.7 001199478.1_23522001_1 - 0.33 11.0 7.1 0.56 10.3 7.1 1.3 1 0 0 1 1 1 0 Haemolysin XhlA DUF4349 PF14257.4 001199478.1_23522001_1 - 0.34 10.2 3.2 0.54 9.6 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) DUF4611 PF15387.4 001199478.1_23522001_1 - 3.3 7.9 12.2 0.11 12.5 5.6 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) UQ_con PF00179.24 001031540.1_23522001_3 - 1.1e-45 154.6 0.0 1.4e-45 154.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA PF00627.29 001031540.1_23522001_3 - 1.1e-10 41.1 0.0 2.1e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain Prok-E2_B PF14461.4 001031540.1_23522001_3 - 7.1e-06 25.6 0.0 1.2e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.20 001031540.1_23522001_3 - 0.0049 17.0 0.0 0.008 16.3 0.0 1.3 1 0 0 1 1 1 1 RWD domain Globin PF00042.20 001031551.1_23521001_1 - 2.5e-15 56.9 0.0 3.3e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 Globin RA PF00788.21 001007851.1_23527001_1 - 2.5e-20 72.8 0.1 6.7e-20 71.4 0.1 1.7 1 1 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Nore1-SARAH PF16517.3 001007851.1_23527001_1 - 2.4e-15 56.1 3.8 4.9e-15 55.1 3.8 1.6 1 0 0 1 1 1 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain PH PF00169.27 204863.1_23523001_2 - 3e-41 140.1 0.1 1.1e-19 70.7 0.1 2.3 2 0 0 2 2 2 2 PH domain DEP PF00610.19 204863.1_23523001_2 - 2.7e-15 56.0 0.0 5.6e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_9 PF15410.4 204863.1_23523001_2 - 4.5e-12 46.3 0.0 7.9e-06 26.1 0.0 2.6 2 0 0 2 2 2 2 Pleckstrin homology domain PH_6 PF15406.4 204863.1_23523001_2 - 1.1e-10 41.7 0.0 6.7e-07 29.5 0.0 2.4 2 0 0 2 2 2 2 Pleckstrin homology domain PH_13 PF16652.3 204863.1_23523001_2 - 7.7e-06 25.7 0.1 0.082 12.7 0.0 2.3 2 0 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.4 204863.1_23523001_2 - 6.5e-05 23.2 6.5 0.46 10.8 0.6 4.0 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.4 204863.1_23523001_2 - 0.00037 20.6 0.4 0.025 14.7 0.0 3.3 2 2 1 3 3 3 1 Pleckstrin homology domain PH_2 PF08458.8 204863.1_23523001_2 - 0.0028 17.9 0.1 0.21 11.8 0.0 2.3 2 0 0 2 2 2 1 Plant pleckstrin homology-like region GFRP PF06399.11 001199522.1_23523001_3 - 3.2e-41 139.0 0.0 4.9e-41 138.4 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase I feedback regulatory protein (GFRP) Ets PF00178.20 001007858.1_23529001_3 - 4.2e-33 113.5 0.3 9.2e-33 112.4 0.3 1.6 1 0 0 1 1 1 1 Ets-domain GABP-alpha PF11620.6 001007858.1_23529001_3 - 6.3e-29 99.9 0.5 1.1e-28 99.1 0.5 1.4 1 0 0 1 1 1 1 GA-binding protein alpha chain SAM_PNT PF02198.14 001007858.1_23529001_3 - 1.3e-27 95.4 0.1 2.5e-27 94.5 0.1 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Mon1 PF03164.12 001031580.1_23525001_3 - 0.15 11.0 0.1 8.8 5.1 0.0 2.6 2 1 1 3 3 3 0 Trafficking protein Mon1 DJ-1_PfpI PF01965.22 001199565.1_23523001_3 - 0.00019 21.2 0.0 0.0011 18.6 0.0 1.9 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.3 001199565.1_23523001_3 - 0.046 13.3 0.0 0.066 12.8 0.0 1.3 1 0 0 1 1 1 0 ThiJ/PfpI family-like Apyrase PF06079.9 001031581.1_23525001_1 - 1.6e-66 224.4 1.1 2.1e-66 224.0 1.1 1.1 1 0 0 1 1 1 1 Apyrase Apyrase PF06079.9 001031581.1_23525001_3 - 4.6e-54 183.5 0.0 5.8e-54 183.1 0.0 1.1 1 0 0 1 1 1 1 Apyrase PI31_Prot_N PF11566.6 001031582.1_23525001_2 - 2.9e-26 92.1 0.0 4e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.9 001031582.1_23525001_2 - 1.1e-08 35.9 14.0 3.1e-08 34.5 14.0 1.8 1 0 0 1 1 1 1 PI31 proteasome regulator DUF1658 PF07871.9 001031583.1_23524001_1 - 4.8 7.2 9.9 0.45 10.4 3.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1658) Complex1_51K PF01512.15 001031583.1_23524001_2 - 2.6e-51 173.3 0.0 4.4e-51 172.6 0.0 1.4 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.7 001031583.1_23524001_2 - 3e-30 104.0 0.3 7.1e-30 102.8 0.0 1.8 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.7 001031583.1_23524001_2 - 6.7e-07 29.0 0.0 1.3e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 SLBB domain DUF3568 PF12092.6 001031583.1_23524001_2 - 0.11 12.5 0.4 0.22 11.5 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) Pex2_Pex12 PF04757.12 001008454.1_23526001_1 - 1.3e-36 126.1 5.6 1.9e-36 125.6 5.6 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4 PF00097.23 001008454.1_23526001_1 - 2.1e-07 30.6 8.8 2.1e-07 30.6 8.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001008454.1_23526001_1 - 0.00074 19.2 5.5 0.002 17.8 5.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001008454.1_23526001_1 - 0.0026 17.6 7.6 0.0088 15.9 7.6 2.0 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.4 001008454.1_23526001_1 - 0.0031 17.2 5.9 0.0031 17.2 5.9 1.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.4 001008454.1_23526001_1 - 0.01 15.5 9.2 0.01 15.5 9.2 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001008454.1_23526001_1 - 0.022 14.8 11.9 0.054 13.5 11.9 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 001008454.1_23526001_1 - 0.15 12.2 8.6 0.42 10.8 8.6 1.9 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.4 001008454.1_23526001_1 - 1.1 9.2 15.0 0.19 11.6 10.2 2.3 2 1 0 2 2 2 0 zinc-RING finger domain DZR PF12773.5 001008454.1_23526001_1 - 1.1 9.2 6.3 4.1 7.4 6.4 2.0 1 1 0 1 1 1 0 Double zinc ribbon Y_phosphatase PF00102.25 001008461.1_23526001_1 - 1.5e-06 27.8 0.0 3.5e-06 26.6 0.0 1.5 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 001008461.1_23526001_1 - 2.5e-06 27.2 0.0 4e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain 7tm_1 PF00001.19 001008464.1_23526001_2 - 4.6e-37 127.6 19.9 9.1e-37 126.6 19.9 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Yippee-Mis18 PF03226.12 001199658.1_23522001_2 - 3.8e-25 88.0 2.7 5.5e-25 87.5 2.7 1.2 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PDCD9 PF07147.10 204939.1_23524001_1 - 1e-181 604.9 0.0 1.3e-181 604.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S30 (PDCD9) XK-related PF09815.7 001034822.1_23525001_1 - 6.4e-84 281.7 29.5 1.1e-83 280.9 29.5 1.3 1 0 0 1 1 1 1 XK-related protein NeuB PF03102.12 001007975.1_23526001_2 - 5.4e-80 268.2 0.0 6.9e-80 267.8 0.0 1.1 1 0 0 1 1 1 1 NeuB family SAF PF08666.10 001007975.1_23526001_2 - 2.6e-06 27.8 0.2 4.5e-06 27.1 0.2 1.4 1 0 0 1 1 1 1 SAF domain ChapFlgA PF13144.4 001007975.1_23526001_2 - 0.045 13.4 0.0 0.073 12.7 0.0 1.2 1 0 0 1 1 1 0 Chaperone for flagella basal body P-ring formation Sec3-PIP2_bind PF15277.4 001199711.1_23523001_2 - 6.1e-24 83.8 0.1 1.1e-23 83.0 0.1 1.4 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Synaptobrevin PF00957.19 001199711.1_23523001_2 - 3.4e-06 26.6 0.5 3.4e-06 26.6 0.5 1.7 2 0 0 2 2 2 1 Synaptobrevin Tissue_fac PF01108.15 001008676.2_23525001_2 - 5e-25 87.2 0.0 1.4e-24 85.9 0.0 1.8 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.8 001008676.2_23525001_2 - 5.1e-17 62.0 0.4 9.7e-17 61.1 0.4 1.5 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.19 001008676.2_23525001_2 - 2e-06 27.9 0.6 1.6e-05 25.0 0.1 2.1 2 0 0 2 2 2 1 Fibronectin type III domain Sec1 PF00995.21 001199714.1_23526001_2 - 1.9e-128 430.1 0.5 2.2e-128 429.9 0.5 1.0 1 0 0 1 1 1 1 Sec1 family Reprolysin_5 PF13688.4 001008682.1_23529001_2 - 2.9e-34 118.8 0.0 5.1e-34 118.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.4 001008682.1_23529001_2 - 7.9e-32 110.6 0.3 1.9e-31 109.3 0.0 1.7 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like ADAM17_MPD PF16698.3 001008682.1_23529001_2 - 4.1e-22 78.2 17.8 4.1e-22 78.2 17.8 3.9 2 1 1 3 3 3 1 Membrane-proximal domain, switch, for ADAM17 Disintegrin PF00200.21 001008682.1_23529001_2 - 2.9e-14 53.5 24.2 2.9e-14 53.5 24.2 3.2 2 0 0 2 2 2 1 Disintegrin Reprolysin_3 PF13582.4 001008682.1_23529001_2 - 1.3e-12 48.2 0.0 2.4e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.17 001008682.1_23529001_2 - 6.9e-10 39.0 0.2 1.5e-05 24.8 0.1 2.9 2 1 0 2 2 2 2 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 001008682.1_23529001_2 - 2.5e-07 30.9 0.1 5.2e-07 29.8 0.1 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_4 PF13583.4 001008682.1_23529001_2 - 5e-05 22.9 0.1 8.4e-05 22.2 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like GCR PF02155.13 001037826.1_23526001_3 - 8.4e-179 594.2 3.2 1e-178 593.9 3.2 1.1 1 0 0 1 1 1 1 Glucocorticoid receptor Hormone_recep PF00104.28 001037826.1_23526001_3 - 4.6e-30 104.6 7.3 5.4e-30 104.4 5.5 1.8 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001037826.1_23526001_3 - 2.9e-28 98.0 13.0 5.7e-28 97.1 13.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Globin PF00042.20 001008786.2_23523001_3 - 4.6e-30 104.3 0.1 7.3e-30 103.6 0.1 1.3 1 0 0 1 1 1 1 Globin V-set PF07686.15 001037832.1_23522001_1 - 2.3e-11 43.7 1.1 3.5e-11 43.1 1.1 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 001037832.1_23522001_1 - 0.002 18.2 0.5 0.0057 16.7 0.5 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001037832.1_23522001_1 - 0.004 17.6 1.1 0.015 15.7 1.1 2.0 1 1 0 1 1 1 1 Immunoglobulin domain DUF3129 PF11327.6 001037832.1_23522001_1 - 0.057 13.7 0.0 0.091 13.0 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3129) Gln-synt_C PF00120.22 001038586.1_23526001_1 - 1.9e-72 244.0 0.0 3.1e-72 243.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.17 001038586.1_23526001_1 - 8.6e-07 28.5 0.8 1.4e-05 24.6 0.1 3.0 3 0 0 3 3 3 1 Glutamine synthetase, beta-Grasp domain Gln-synt_N_2 PF16952.3 001038586.1_23526001_1 - 8.1e-05 22.3 0.0 0.00016 21.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase N-terminal domain HECT PF00632.23 001039260.1_23529001_3 - 4.4e-99 331.7 0.4 6.2e-99 331.2 0.4 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 001039260.1_23529001_3 - 1.3e-46 156.1 32.4 1.1e-13 50.7 5.0 4.8 4 0 0 4 4 4 4 WW domain SRP-alpha_N PF04086.11 001039277.1_23527001_2 - 5.2e-67 226.7 12.8 6.6e-67 226.3 12.8 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.20 001039277.1_23527001_2 - 5.6e-48 163.1 0.4 2.9e-47 160.7 0.4 2.0 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.17 001039277.1_23527001_2 - 6.3e-09 35.8 0.2 2.4e-08 34.0 0.1 2.0 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain ArgK PF03308.14 001039277.1_23527001_2 - 2.5e-07 29.8 0.1 4.4e-07 29.0 0.1 1.3 1 0 0 1 1 1 1 ArgK protein CbiA PF01656.21 001039277.1_23527001_2 - 0.0036 17.2 0.0 0.067 13.1 0.0 2.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.4 001039277.1_23527001_2 - 0.021 14.4 0.1 0.038 13.6 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.4 001039277.1_23527001_2 - 0.074 13.1 0.0 0.19 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain YusW PF14039.4 001039277.1_23527001_2 - 0.65 10.4 6.1 11 6.5 0.8 3.4 3 0 0 3 3 3 0 YusW-like protein BIR PF00653.19 001012319.1_23522001_1 - 3.6e-23 81.9 2.1 3.6e-23 81.9 2.1 2.8 3 0 0 3 3 3 1 Inhibitor of Apoptosis domain DUF3534 PF12053.6 001039280.2_23529001_3 - 2.6e-58 196.3 1.6 9.2e-58 194.5 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3534) PDZ PF00595.22 001039280.2_23529001_3 - 3.6e-36 123.2 4.3 1.6e-14 53.9 0.1 3.5 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001039280.2_23529001_3 - 1.3e-14 54.1 0.5 1e-06 28.8 0.1 3.7 3 1 0 3 3 3 3 PDZ domain TPR_11 PF13414.4 001039280.2_23529001_3 - 0.12 11.9 0.2 0.25 10.9 0.2 1.5 1 0 0 1 1 1 0 TPR repeat Myelin_PLP PF01275.17 001012545.1_23523001_1 - 3.5e-99 331.3 18.9 4.5e-99 331.0 18.9 1.1 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) PspB PF06667.10 001012545.1_23523001_1 - 0.11 12.5 0.1 0.23 11.4 0.1 1.6 1 0 0 1 1 1 0 Phage shock protein B DUF1049 PF06305.9 001012545.1_23523001_1 - 0.41 10.4 0.0 0.41 10.4 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1049) Myelin_PLP PF01275.17 001012579.1_23523001_1 - 1.3e-92 309.9 24.2 1.5e-92 309.6 24.2 1.0 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) E2F_CC-MB PF16421.3 001244738.1_23524001_2 - 8.5e-33 112.6 1.0 1.5e-32 111.8 1.0 1.4 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.18 001244738.1_23524001_2 - 3e-23 81.5 0.0 6.4e-23 80.4 0.0 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.17 001244738.1_23524001_2 - 0.063 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB NAGidase PF07555.11 001039305.2_23529001_3 - 1e-80 271.1 0.0 1.5e-80 270.5 0.0 1.2 1 0 0 1 1 1 1 beta-N-acetylglucosaminidase CTNNB1_binding PF08347.9 205013.2_23525001_1 - 4.9e-84 281.4 3.6 4.9e-84 281.4 3.6 1.8 2 0 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.17 205013.2_23525001_1 - 1.3e-21 76.7 2.6 1.5e-21 76.4 0.7 2.2 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.8 205013.2_23525001_1 - 2.2e-08 34.4 0.8 5e-08 33.3 0.8 1.6 1 0 0 1 1 1 1 HMG-box domain JAB PF01398.19 001039311.1_23523001_2 - 9.5e-34 115.8 0.0 1.6e-33 115.0 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.4 001039311.1_23523001_2 - 0.00029 20.5 0.0 0.00049 19.7 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.11 001039311.1_23523001_2 - 0.0089 16.0 0.0 0.018 14.9 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) BTG PF07742.10 001012534.1_23529001_1 - 4.9e-37 126.2 0.0 1.1e-36 125.1 0.0 1.6 2 0 0 2 2 2 1 BTG family PAM2 PF07145.13 001012534.1_23529001_1 - 5.3e-12 44.4 0.2 2.7e-05 23.4 0.0 2.9 2 0 0 2 2 2 2 Ataxin-2 C-terminal region Ras PF00071.20 205016.1_23522001_3 - 4.8e-55 185.4 0.0 5.6e-55 185.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 205016.1_23522001_3 - 6.4e-23 81.1 0.0 8.4e-23 80.8 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 205016.1_23522001_3 - 5e-08 32.5 0.0 6.5e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family CagD PF16567.3 205016.1_23522001_3 - 0.086 12.5 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Pathogenicity island component CagD Hydrolase PF00702.24 001252272.1_23522001_1 - 7.4e-18 65.5 0.0 1.2e-17 64.8 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 001252272.1_23522001_1 - 6.2e-12 46.2 0.0 1.1e-11 45.4 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.4 001252272.1_23522001_1 - 7.8e-06 25.9 0.0 0.0089 16.0 0.0 2.5 3 0 0 3 3 3 2 Haloacid dehalogenase-like hydrolase UMPH-1 PF05822.10 001252272.1_23522001_1 - 8.9e-06 25.3 0.0 1.5e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) Put_Phosphatase PF06888.10 001252272.1_23522001_1 - 3.7e-05 23.1 0.0 0.00011 21.6 0.0 1.7 2 1 0 2 2 2 1 Putative Phosphatase Acid_phosphat_B PF03767.12 001252272.1_23522001_1 - 0.0017 17.8 0.0 0.12 11.8 0.0 2.1 2 0 0 2 2 2 1 HAD superfamily, subfamily IIIB (Acid phosphatase) Hydrolase_3 PF08282.10 001252272.1_23522001_1 - 0.021 14.5 0.0 0.93 9.0 0.0 2.4 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.4 001252272.1_23522001_1 - 0.067 13.1 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 HAD-hyrolase-like StbA PF06406.9 001252272.1_23522001_1 - 0.068 12.3 0.0 0.18 10.8 0.0 1.6 2 0 0 2 2 2 0 StbA protein Ras PF00071.20 001012551.1_23525001_1 - 9.9e-63 210.4 0.1 1.3e-62 210.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001012551.1_23525001_1 - 1.8e-34 118.4 0.1 2.9e-34 117.7 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001012551.1_23525001_1 - 4.5e-12 45.6 0.1 6.7e-12 45.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001012551.1_23525001_1 - 2.5e-06 27.4 0.1 3.7e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 001012551.1_23525001_1 - 0.0012 19.0 0.0 0.0057 16.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.25 001012551.1_23525001_1 - 0.0017 17.8 0.1 0.0037 16.7 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001012551.1_23525001_1 - 0.002 17.9 0.4 0.097 12.4 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 001012551.1_23525001_1 - 0.041 13.1 0.0 0.063 12.5 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_16 PF13191.4 001012551.1_23525001_1 - 0.081 13.2 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.25 001012551.1_23525001_1 - 0.13 12.7 0.1 0.24 11.8 0.1 1.3 1 1 0 1 1 1 0 ABC transporter P66_CC PF16563.3 001012552.2_23526001_1 - 2.1e-19 68.7 12.2 4.9e-19 67.5 12.2 1.6 1 0 0 1 1 1 1 Coiled-coil and interaction region of P66A and P66B with MBD2 GATA PF00320.25 001012552.2_23526001_1 - 1.9e-07 30.4 8.0 4.7e-07 29.2 8.0 1.7 1 0 0 1 1 1 1 GATA zinc finger DUF2299 PF10061.7 001012552.2_23526001_1 - 0.061 12.9 0.9 0.14 11.8 0.9 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2299) Mu-like_Pro PF10123.7 001012552.2_23526001_1 - 0.29 10.5 4.2 0.087 12.2 0.3 1.9 2 0 0 2 2 2 0 Mu-like prophage I protein TPR_1 PF00515.26 001254739.1_23525001_2 - 1e-15 56.6 4.4 9.5e-06 25.1 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat FKBP_C PF00254.26 001254739.1_23525001_2 - 2.8e-14 53.0 0.0 5.3e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.15 001254739.1_23525001_2 - 3.4e-13 48.5 4.4 2.1e-05 24.1 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 001254739.1_23525001_2 - 4.2e-08 33.0 1.8 0.0015 18.4 0.1 2.4 2 0 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.4 001254739.1_23525001_2 - 5.5e-08 32.9 0.0 5.9e-05 23.4 0.0 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.4 001254739.1_23525001_2 - 2.7e-07 30.0 0.6 0.0001 21.8 0.0 2.6 2 0 0 2 2 2 1 TPR repeat TPR_8 PF13181.4 001254739.1_23525001_2 - 8.4e-07 28.6 2.6 0.00026 20.8 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.4 001254739.1_23525001_2 - 1e-06 28.7 0.0 1.4e-05 25.1 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.4 001254739.1_23525001_2 - 2.9e-06 27.7 0.4 0.00085 19.8 0.1 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.4 001254739.1_23525001_2 - 6.2e-06 26.3 0.7 0.0011 19.1 0.2 2.8 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.4 001254739.1_23525001_2 - 6.6e-06 25.7 0.2 0.011 15.6 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.4 001254739.1_23525001_2 - 0.00012 22.4 0.2 0.00045 20.5 0.2 2.0 1 1 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.5 001254739.1_23525001_2 - 0.00083 19.4 0.5 0.0042 17.1 0.0 2.3 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.4 001254739.1_23525001_2 - 0.00093 19.3 1.9 0.032 14.5 0.0 3.4 4 0 0 4 4 3 1 Tetratricopeptide repeat NARP1 PF12569.6 001254739.1_23525001_2 - 0.0055 15.5 0.3 0.0075 15.1 0.3 1.1 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 TPR_6 PF13174.4 001254739.1_23525001_2 - 0.037 14.5 1.1 0.74 10.5 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 001254739.1_23525001_2 - 0.044 13.5 3.4 1.8 8.4 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat SPO22 PF08631.8 001254739.1_23525001_2 - 0.097 12.0 0.4 0.15 11.3 0.4 1.2 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like TPR_21 PF09976.7 001254739.1_23525001_2 - 0.1 12.2 0.5 0.85 9.2 0.1 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain MIT PF04212.16 001254739.1_23525001_2 - 0.16 11.9 1.0 11 6.1 0.0 2.8 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Synaptobrevin PF00957.19 001039489.1_23522001_3 - 3.7e-35 119.5 4.8 4.7e-35 119.1 4.8 1.1 1 0 0 1 1 1 1 Synaptobrevin ODV-E18 PF10717.7 001039489.1_23522001_3 - 0.019 14.7 0.1 0.037 13.8 0.1 1.5 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 ASFV_J13L PF05568.9 001039489.1_23522001_3 - 0.077 12.6 6.7 0.044 13.4 3.4 2.0 2 0 0 2 2 2 0 African swine fever virus J13L protein Rifin_STEVOR PF02009.14 001039489.1_23522001_3 - 0.085 12.6 0.2 0.1 12.3 0.2 1.1 1 0 0 1 1 1 0 Rifin/stevor family MCU PF04678.11 001039489.1_23522001_3 - 0.11 12.5 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Baculo_F PF12259.6 001039489.1_23522001_3 - 0.13 10.6 0.1 0.16 10.3 0.1 1.0 1 0 0 1 1 1 0 Baculovirus F protein Env-gp36 PF09590.8 001039489.1_23522001_3 - 0.14 10.4 0.0 0.19 10.0 0.0 1.1 1 0 0 1 1 1 0 Lentivirus surface glycoprotein DUF4736 PF15883.3 001039489.1_23522001_3 - 0.44 10.1 2.7 4.7 6.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4736) Septin PF00735.16 001012559.1_23525001_2 - 1.2e-122 408.4 0.1 1.2e-122 408.4 0.1 1.6 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.21 001012559.1_23525001_2 - 1.1e-06 28.5 0.1 3.4e-06 27.0 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.14 001012559.1_23525001_2 - 1.4e-05 25.0 8.9 0.00031 20.6 0.0 3.3 3 0 0 3 3 3 2 Protein of unknown function, DUF258 AIG1 PF04548.14 001012559.1_23525001_2 - 0.0025 17.0 0.0 0.0025 17.0 0.0 2.1 2 0 0 2 2 1 1 AIG1 family AAA_22 PF13401.4 001012559.1_23525001_2 - 0.024 14.8 0.0 0.075 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 001012559.1_23525001_2 - 0.026 14.8 0.4 0.059 13.6 0.0 1.7 2 0 0 2 2 1 0 AAA ATPase domain Exonuc_VII_L PF02601.13 001012559.1_23525001_2 - 0.032 13.7 10.5 0.052 13.0 10.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ras PF00071.20 001012559.1_23525001_2 - 0.047 13.1 0.7 0.088 12.3 0.0 1.8 2 0 0 2 2 2 0 Ras family FeoB_N PF02421.16 001012559.1_23525001_2 - 0.058 12.8 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B ABC_tran PF00005.25 001012559.1_23525001_2 - 0.064 13.6 0.0 0.064 13.6 0.0 2.4 2 0 0 2 2 2 0 ABC transporter AAA_29 PF13555.4 001012559.1_23525001_2 - 0.066 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.25 001012559.1_23525001_2 - 0.11 11.9 9.4 1.6 8.1 0.1 3.8 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001012559.1_23525001_2 - 0.17 11.0 0.0 0.17 11.0 0.0 2.7 3 0 0 3 3 2 0 Gtr1/RagA G protein conserved region Fez1 PF06818.13 001012559.1_23525001_2 - 1.5 9.1 26.2 0.12 12.6 21.2 1.6 2 0 0 2 2 2 0 Fez1 DUF87 PF01935.15 001012559.1_23525001_2 - 3.3 7.5 10.0 37 4.1 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function DUF87 DUF2937 PF11157.6 001012559.1_23525001_2 - 6.2 6.3 9.7 8.5 5.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) Toprim PF01751.20 001256490.1_23523001_2 - 0.0073 16.4 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 Toprim domain CTP_transf_like PF01467.24 001291966.1_23524001_3 - 2.2e-43 147.7 0.0 1.2e-28 100.0 0.0 2.2 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.10 001291966.1_23524001_3 - 0.00013 21.7 0.3 0.15 11.8 0.0 3.3 3 0 0 3 3 3 2 FAD synthetase CHAP PF05257.14 001291966.1_23524001_3 - 0.045 14.2 0.0 0.13 12.7 0.0 1.6 1 1 0 1 1 1 0 CHAP domain DEK_C PF08766.9 001012560.1_23526001_3 - 4.6e-18 64.8 0.4 8.4e-18 63.9 0.4 1.5 1 0 0 1 1 1 1 DEK C terminal domain SAP PF02037.25 001012560.1_23526001_3 - 1.6e-05 24.4 0.1 5e-05 22.8 0.1 2.0 1 0 0 1 1 1 1 SAP domain DUF2052 PF09747.7 001012560.1_23526001_3 - 1 9.3 35.6 2 8.4 14.7 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) PNISR PF15996.3 001012560.1_23526001_3 - 1.7 8.6 38.5 3.9 7.5 9.0 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR MIP-T3 PF10243.7 001012560.1_23526001_3 - 2.3 6.7 54.5 0.16 10.5 28.7 2.1 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 Cpn60_TCP1 PF00118.22 001012563.2_23524001_2 - 2.3e-160 534.3 3.7 2.9e-160 534.0 3.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family AAA PF00004.27 001292069.1_23523001_1 - 4.8e-43 146.6 0.0 1.3e-42 145.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.12 001292069.1_23523001_1 - 2.3e-07 31.0 0.0 5.7e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.12 001292069.1_23523001_1 - 2.9e-06 27.2 0.0 1.6e-05 24.8 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 001292069.1_23523001_1 - 4.2e-06 27.1 0.2 7.8e-05 23.0 0.0 2.7 3 1 0 4 4 2 1 AAA ATPase domain AAA_22 PF13401.4 001292069.1_23523001_1 - 3e-05 24.2 0.9 0.0055 16.8 0.2 2.7 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.10 001292069.1_23523001_1 - 9.6e-05 21.6 0.0 0.00019 20.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.11 001292069.1_23523001_1 - 0.0016 17.3 0.0 0.0033 16.3 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.15 001292069.1_23523001_1 - 0.0018 17.9 0.0 0.0039 16.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.4 001292069.1_23523001_1 - 0.0019 18.3 0.0 0.0038 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 001292069.1_23523001_1 - 0.0027 18.1 0.2 0.021 15.2 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_3 PF07726.9 001292069.1_23523001_1 - 0.0065 16.2 0.0 0.018 14.8 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.19 001292069.1_23523001_1 - 0.0066 15.7 0.1 0.017 14.4 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ATPase PF06745.11 001292069.1_23523001_1 - 0.0088 15.3 0.0 0.025 13.8 0.0 1.7 1 0 0 1 1 1 1 KaiC PhoH PF02562.14 001292069.1_23523001_1 - 0.0096 15.3 0.0 0.14 11.5 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein RILP PF11461.6 001292069.1_23523001_1 - 0.02 15.0 3.4 0.053 13.6 3.4 1.7 1 0 0 1 1 1 0 Rab interacting lysosomal protein AAA_28 PF13521.4 001292069.1_23523001_1 - 0.02 15.0 0.0 0.04 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.24 001292069.1_23523001_1 - 0.024 14.2 0.1 0.1 12.1 0.0 2.1 2 1 0 2 2 1 0 Sigma-54 interaction domain AAA_24 PF13479.4 001292069.1_23523001_1 - 0.028 14.0 0.0 0.078 12.6 0.0 1.8 1 1 1 2 2 2 0 AAA domain TsaE PF02367.15 001292069.1_23523001_1 - 0.044 13.7 0.0 0.082 12.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.15 001292069.1_23523001_1 - 0.049 12.6 0.0 0.084 11.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.4 001292069.1_23523001_1 - 0.049 13.2 0.4 0.42 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.11 001292069.1_23523001_1 - 0.054 12.5 0.0 0.11 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_25 PF13481.4 001292069.1_23523001_1 - 0.054 12.9 0.0 0.17 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.4 001292069.1_23523001_1 - 0.058 13.3 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.20 001292069.1_23523001_1 - 0.066 13.5 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_17 PF13207.4 001292069.1_23523001_1 - 0.089 13.1 0.7 0.49 10.7 0.0 2.4 3 0 0 3 3 2 0 AAA domain Zeta_toxin PF06414.10 001292069.1_23523001_1 - 0.11 11.6 0.0 0.31 10.2 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin AAA_19 PF13245.4 001292069.1_23523001_1 - 0.14 12.4 0.2 0.49 10.6 0.1 1.8 1 1 0 1 1 1 0 AAA domain SlyX PF04102.10 001292069.1_23523001_1 - 0.15 12.6 2.3 0.53 10.8 2.3 2.0 1 0 0 1 1 1 0 SlyX Laminin_II PF06009.10 001292069.1_23523001_1 - 0.23 11.4 3.7 1.3 9.0 1.0 2.7 3 0 0 3 3 3 0 Laminin Domain II DivIC PF04977.13 001292069.1_23523001_1 - 0.26 10.9 3.0 0.63 9.7 3.0 1.6 1 0 0 1 1 1 0 Septum formation initiator MscS_porin PF12795.5 001292069.1_23523001_1 - 7.2 5.9 12.7 12 5.2 12.7 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain SAM_decarbox PF01536.14 001012569.1_23527001_3 - 2.9e-124 414.5 0.8 3.6e-124 414.2 0.8 1.1 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase BRICHOS PF04089.12 001012571.1_23524001_3 - 2.7e-18 65.7 0.0 4.8e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 BRICHOS domain SH3BGR PF04908.13 001012574.1_23527001_1 - 1.2e-42 144.0 0.0 1.7e-42 143.5 0.0 1.2 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.22 001012574.1_23527001_1 - 0.015 15.4 0.0 0.026 14.6 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin Hormone_2 PF00123.18 001040464.1_23522001_3 - 3.2e-14 52.4 0.6 1.6e-13 50.2 0.1 2.3 2 0 0 2 2 2 1 Peptide hormone Sec10 PF07393.9 001012589.1_23529001_1 - 1.7e-151 505.9 30.1 6.2e-150 500.8 23.0 3.3 2 1 0 2 2 2 1 Exocyst complex component Sec10 V_ATPase_I PF01496.17 001012589.1_23529001_1 - 0.033 12.0 11.9 0.063 11.0 11.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BLOC1_2 PF10046.7 001012589.1_23529001_1 - 0.11 12.7 2.7 0.45 10.7 2.7 2.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Jnk-SapK_ap_N PF09744.7 001012589.1_23529001_1 - 0.14 12.2 12.1 0.013 15.6 6.6 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 OmpH PF03938.12 001012589.1_23529001_1 - 0.53 10.1 14.2 1.1 9.1 13.7 1.8 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) EF-hand_1 PF00036.30 001293208.1_23524001_2 - 7.5e-20 68.8 15.9 6.2e-05 22.1 0.3 6.1 6 1 0 6 6 6 4 EF hand EF-hand_7 PF13499.4 001293208.1_23524001_2 - 2.1e-19 69.6 15.6 2.6e-07 30.9 0.1 3.6 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 001293208.1_23524001_2 - 5.7e-16 57.1 8.0 0.0056 16.0 0.1 5.1 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.4 001293208.1_23524001_2 - 9.8e-15 53.0 15.3 0.006 16.3 0.1 5.9 6 0 0 6 6 6 4 EF-hand domain EF-hand_8 PF13833.4 001293208.1_23524001_2 - 1.3e-06 28.0 15.9 0.086 12.5 0.0 5.5 5 1 1 6 6 6 4 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001293208.1_23524001_2 - 0.088 13.0 11.3 0.3 11.3 0.2 3.7 2 2 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Arm PF00514.21 205081.1_23527001_1 - 1.6e-41 139.0 18.6 1.3e-07 31.3 0.1 11.8 13 0 0 13 13 13 7 Armadillo/beta-catenin-like repeat Cnd1 PF12717.5 205081.1_23527001_1 - 2e-08 34.3 1.3 0.0051 16.7 0.3 4.4 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 205081.1_23527001_1 - 4.4e-06 26.9 6.9 1.5 9.2 0.0 6.3 5 1 1 6 6 6 2 HEAT-like repeat HEAT PF02985.20 205081.1_23527001_1 - 5.7e-06 26.0 1.5 23 5.5 0.0 5.9 5 0 0 5 5 5 0 HEAT repeat Adaptin_N PF01602.18 205081.1_23527001_1 - 6.3e-06 24.9 1.7 0.0013 17.2 1.1 3.0 3 0 0 3 3 3 1 Adaptin N terminal region HEAT_2 PF13646.4 205081.1_23527001_1 - 2.3e-05 24.6 4.8 0.044 14.0 0.4 4.9 4 1 1 5 5 5 1 HEAT repeats Atx10homo_assoc PF09759.7 205081.1_23527001_1 - 0.0014 18.5 0.9 0.016 15.2 0.2 3.1 3 1 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain RasGEF_N_2 PF14663.4 205081.1_23527001_1 - 0.0023 18.1 3.5 7.9 6.7 0.0 4.7 4 1 1 5 5 5 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF3361 PF11841.6 205081.1_23527001_1 - 0.003 17.4 1.4 4.7 7.0 0.0 4.4 2 1 1 4 4 4 1 Domain of unknown function (DUF3361) Queuosine_synth PF02547.13 205081.1_23527001_1 - 0.027 13.5 0.4 0.051 12.5 0.1 1.5 2 0 0 2 2 2 0 Queuosine biosynthesis protein Arm_2 PF04826.11 205081.1_23527001_1 - 0.045 13.1 3.3 0.95 8.7 0.0 3.3 2 1 1 3 3 3 0 Armadillo-like Pkinase PF00069.23 001012595.3_23527001_1 - 7.5e-07 28.6 0.1 1.9e-05 24.0 0.1 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001012595.3_23527001_1 - 0.0014 17.9 0.0 0.0024 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Utp21 PF04192.10 001044634.1_23527001_2 - 1.2e-64 217.9 0.0 1.9e-64 217.3 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.30 001044634.1_23527001_2 - 1.2e-18 67.0 10.2 8.3e-09 35.8 1.3 8.3 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001044634.1_23527001_2 - 8.9e-11 41.8 0.0 0.0008 19.5 0.0 5.9 4 1 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001044634.1_23527001_2 - 0.0012 18.6 0.0 0.84 9.3 0.0 3.6 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Utp12 PF04003.10 001044634.1_23527001_2 - 0.0043 17.2 0.4 0.0081 16.3 0.4 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family EF-hand_1 PF00036.30 001293230.1_23524001_2 - 2.1e-19 67.4 16.1 6.2e-05 22.1 0.3 6.1 6 1 0 6 6 6 4 EF hand EF-hand_7 PF13499.4 001293230.1_23524001_2 - 4.5e-19 68.6 16.7 2.7e-07 30.8 0.2 3.6 2 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 001293230.1_23524001_2 - 7.5e-16 56.7 8.2 0.0056 16.0 0.1 5.1 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.4 001293230.1_23524001_2 - 9.9e-15 53.0 15.2 0.006 16.3 0.1 5.9 6 0 0 6 6 6 4 EF-hand domain EF-hand_8 PF13833.4 001293230.1_23524001_2 - 2.6e-07 30.2 13.1 0.086 12.5 0.0 5.1 5 1 1 6 6 6 4 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001293230.1_23524001_2 - 0.061 13.5 10.3 0.29 11.4 0.2 3.7 2 2 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region zf-H2C2_2 PF13465.4 001044642.1_23525001_3 - 1.1e-49 164.6 90.3 2.2e-09 37.2 2.0 12.3 12 0 0 12 12 12 10 Zinc-finger double domain zf-C2H2 PF00096.24 001044642.1_23525001_3 - 2.3e-29 100.0 108.4 8.8e-06 25.8 1.9 12.2 13 0 0 13 13 12 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001044642.1_23525001_3 - 5.9e-26 88.8 93.0 0.0031 18.1 1.1 11.7 11 0 0 11 11 11 10 C2H2-type zinc finger BTB PF00651.29 001044642.1_23525001_3 - 2e-18 66.5 0.0 3.8e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_6 PF13912.4 001044642.1_23525001_3 - 2.2e-07 30.5 72.5 2.6e-05 23.9 1.2 10.5 10 0 0 10 10 10 5 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001044642.1_23525001_3 - 3.5e-05 23.3 4.8 0.00017 21.1 0.6 7.7 8 0 0 8 8 7 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 001044642.1_23525001_3 - 0.00017 21.7 50.7 0.01 16.0 0.5 9.6 10 0 0 10 10 10 4 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 001044642.1_23525001_3 - 0.0015 18.7 15.1 0.0022 18.1 2.9 7.0 5 2 2 7 7 7 3 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 001044642.1_23525001_3 - 0.005 17.0 68.2 0.22 11.8 1.5 10.4 10 0 0 10 10 10 4 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.4 001044642.1_23525001_3 - 0.016 14.8 0.6 0.016 14.8 0.6 8.8 9 1 0 9 9 9 0 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.3 001044642.1_23525001_3 - 0.027 14.6 51.6 0.76 10.0 3.9 6.1 1 1 5 6 6 6 0 C2H2-type zinc ribbon DUF2387 PF09526.8 001044642.1_23525001_3 - 0.048 13.7 0.4 0.048 13.7 0.4 3.5 3 0 0 3 3 3 0 Probable metal-binding protein (DUF2387) GAGA PF09237.9 001044642.1_23525001_3 - 2.8 7.7 33.4 0.11 12.2 0.5 5.9 3 2 3 7 7 7 0 GAGA factor zinc_ribbon_15 PF17032.3 001044642.1_23525001_3 - 4.3 8.0 41.5 7.3 7.3 0.5 5.8 2 1 3 5 5 4 0 zinc-ribbon family DUF3268 PF11672.6 001044642.1_23525001_3 - 7.4 6.8 28.3 0.87 9.8 0.3 5.3 4 1 3 7 7 7 0 zinc-finger-containing domain DER1 PF04511.13 001270716.1_23523001_3 - 5.6e-69 231.7 13.8 7.7e-69 231.2 13.8 1.2 1 0 0 1 1 1 1 Der1-like family Oleosin PF01277.15 001270716.1_23523001_3 - 0.0025 17.4 1.4 0.005 16.4 0.1 2.0 1 1 1 2 2 2 1 Oleosin Fz PF01392.20 205099.1_23525001_2 - 8.5e-26 90.7 4.4 8.5e-26 90.7 4.4 2.3 2 0 0 2 2 2 1 Fz domain Orn_Arg_deC_N PF02784.14 001293656.1_23524001_1 - 7.2e-64 215.4 0.0 9e-64 215.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001293656.1_23524001_1 - 2.6e-15 56.3 0.0 4.6e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 001293656.1_23524001_1 - 1.9e-05 24.1 0.0 5.1e-05 22.7 0.0 1.6 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel PMAIP1 PF15150.4 001302097.1_23522001_3 - 7.8e-17 60.8 0.2 1.6e-16 59.8 0.2 1.5 1 0 0 1 1 1 1 Phorbol-12-myristate-13-acetate-induced Nnf1 PF03980.12 001044676.1_23522001_1 - 3.7e-16 59.3 0.2 3.7e-16 59.3 0.2 1.5 2 0 0 2 2 2 1 Nnf1 MIase PF02426.14 001044676.1_23522001_1 - 0.072 13.1 1.1 0.11 12.5 0.1 1.8 2 0 0 2 2 2 0 Muconolactone delta-isomerase tRNA-synt_1c PF00749.19 001012782.1_23526001_1 - 2.3e-113 378.1 0.0 3e-113 377.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.13 001012782.1_23526001_1 - 6.5e-47 159.4 0.0 1.2e-46 158.6 0.0 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.16 001012782.1_23526001_1 - 2.5e-46 157.6 0.0 4.9e-46 156.6 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.13 001012782.1_23526001_1 - 9.4e-30 103.3 2.1 1.7e-29 102.4 2.1 1.5 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 zf-C2H2 PF00096.24 001044684.1_23524001_3 - 3.2e-15 55.5 26.4 1.7e-06 28.0 0.8 4.2 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001044684.1_23524001_3 - 9.6e-15 54.1 7.6 7.3e-09 35.6 1.2 5.0 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001044684.1_23524001_3 - 1.8e-07 31.3 28.6 0.00018 21.9 1.4 4.3 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001044684.1_23524001_3 - 0.0063 16.7 2.6 6.7 7.0 0.2 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001044684.1_23524001_3 - 0.0068 16.2 1.3 0.0068 16.2 1.3 3.5 3 1 0 3 3 3 2 C2H2-type zinc finger zf-Di19 PF05605.10 001044684.1_23524001_3 - 0.0079 16.3 1.8 0.0079 16.3 1.8 2.8 1 1 0 2 2 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.3 001044684.1_23524001_3 - 0.016 15.4 3.4 0.016 15.4 3.4 2.0 1 1 0 1 1 1 0 C2H2-type zinc ribbon GFA PF04828.12 001044684.1_23524001_3 - 0.022 15.0 6.6 0.17 12.1 1.3 2.5 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zf-met PF12874.5 001044684.1_23524001_3 - 0.16 12.3 7.0 10 6.5 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type FOXP-CC PF16159.3 001044684.1_23524001_3 - 0.19 12.3 18.2 4.3 7.9 0.3 4.7 3 2 2 5 5 5 0 FOXP coiled-coil domain zf-BED PF02892.13 001044684.1_23524001_3 - 1 9.3 12.7 16 5.5 2.2 3.5 1 1 2 3 3 3 0 BED zinc finger zf-H2C2_5 PF13909.4 001044684.1_23524001_3 - 2 8.1 13.3 0.26 11.0 0.3 3.5 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2_aberr PF17017.3 001044684.1_23524001_3 - 2.5 8.1 4.1 13 5.7 0.1 2.2 2 0 0 2 2 2 0 Aberrant zinc-finger MAS20 PF02064.13 205137.1_23523001_1 - 4.4 7.3 9.9 6.5 6.7 9.9 1.2 1 0 0 1 1 1 0 MAS20 protein import receptor Homeobox PF00046.27 205137.1_23523001_2 - 5.5e-20 70.8 5.9 1.1e-19 69.8 5.9 1.5 1 0 0 1 1 1 1 Homeobox domain SNF2_N PF00176.21 205139.1_23529001_1 - 1.1e-72 244.5 1.9 1.1e-72 244.5 1.9 2.2 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.23 205139.1_23529001_1 - 2.9e-21 75.2 0.1 3.1e-20 71.9 0.1 2.5 2 0 0 2 2 2 1 Bromodomain HSA PF07529.11 205139.1_23529001_1 - 5.8e-21 74.5 16.2 5.8e-21 74.5 16.2 4.2 4 0 0 4 4 4 1 HSA Helicase_C PF00271.29 205139.1_23529001_1 - 1e-20 74.0 0.6 2.4e-19 69.6 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain BRK PF07533.14 205139.1_23529001_1 - 1.2e-17 63.1 0.1 2.3e-17 62.2 0.1 1.6 1 0 0 1 1 1 1 BRK domain SnAC PF14619.4 205139.1_23529001_1 - 5.6e-17 62.0 7.3 5.6e-17 62.0 7.3 6.4 8 2 0 8 8 8 1 Snf2-ATP coupling, chromatin remodelling complex QLQ PF08880.9 205139.1_23529001_1 - 1.1e-14 53.7 4.3 2.4e-14 52.6 4.3 1.6 1 0 0 1 1 1 1 QLQ ResIII PF04851.13 205139.1_23529001_1 - 1.1e-08 35.1 0.0 1.1e-08 35.1 0.0 3.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.27 205139.1_23529001_1 - 0.0002 21.0 0.0 0.00048 19.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase NAD_binding_5 PF07994.10 205139.1_23529001_1 - 1.5 8.0 4.4 3.3 6.9 4.4 1.5 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase S_100 PF01023.17 001302142.1_23523001_2 - 2e-19 68.8 0.8 3.4e-19 68.2 0.8 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 001302142.1_23523001_2 - 0.00073 19.8 1.6 0.0015 18.8 1.6 1.6 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001302142.1_23523001_2 - 0.0019 17.5 0.3 0.0047 16.2 0.3 1.7 1 0 0 1 1 1 1 EF hand ECR1_N PF14382.4 001012798.2_23524001_1 - 1.6e-16 59.6 1.1 2.6e-16 59.0 1.1 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.3 001012798.2_23524001_1 - 2.1e-13 50.2 0.0 4.3e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.7 001012798.2_23524001_1 - 0.026 15.1 0.3 1.5 9.4 0.1 2.2 2 0 0 2 2 2 0 Exosome component EXOSC1/CSL4 PKI PF02827.14 001302151.1_23522001_3 - 9.1e-21 73.7 0.8 1.5e-20 73.0 0.8 1.4 1 0 0 1 1 1 1 cAMP-dependent protein kinase inhibitor IQ PF00612.25 001302155.1_23522001_1 - 4.7e-05 22.7 0.4 8.8e-05 21.8 0.4 1.5 1 0 0 1 1 1 1 IQ calmodulin-binding motif Tom37 PF10568.7 001079483.1_23526001_3 - 5.9e-40 136.4 0.2 9.4e-40 135.8 0.2 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.2 001079483.1_23526001_3 - 1.1e-21 76.3 0.4 2e-21 75.4 0.4 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.2 001079483.1_23526001_3 - 1.5e-15 57.6 0.0 2.4e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.4 001079483.1_23526001_3 - 1.2e-06 28.2 0.0 3.1e-06 26.9 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Costars PF14705.4 001302176.1_23522001_1 - 4e-30 103.7 0.4 5.5e-30 103.2 0.4 1.2 1 0 0 1 1 1 1 Costars Cyclotide PF03784.11 001302176.1_23522001_2 - 0.057 13.4 2.4 0.1 12.6 2.4 1.4 1 0 0 1 1 1 0 Cyclotide family dUTPase PF00692.17 001079488.1_23526001_1 - 4.4e-49 165.3 0.0 6.4e-49 164.8 0.0 1.2 1 0 0 1 1 1 1 dUTPase SNN_transmemb PF09049.8 001302180.1_23522001_2 - 5.7e-21 74.0 8.8 9.8e-21 73.3 8.8 1.4 1 0 0 1 1 1 1 Stannin transmembrane SNN_linker PF09050.8 001302180.1_23522001_2 - 1.1e-19 69.7 2.8 1.1e-19 69.7 2.8 1.6 2 0 0 2 2 2 1 Stannin unstructured linker SNN_cytoplasm PF09051.8 001302180.1_23522001_2 - 2.1e-19 68.9 0.1 3e-19 68.4 0.1 1.2 1 0 0 1 1 1 1 Stannin cytoplasmic Sec7 PF01369.18 001012815.1_23525001_3 - 1.6e-64 216.8 0.0 2.4e-64 216.3 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.27 001012815.1_23525001_3 - 5.9e-27 94.1 0.1 9.9e-27 93.4 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 001012815.1_23525001_3 - 0.00014 22.1 0.1 0.00043 20.5 0.1 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.4 001012815.1_23525001_3 - 0.019 14.9 0.0 0.16 11.9 0.0 2.4 2 1 0 2 2 2 0 PH domain PH_6 PF15406.4 001012815.1_23525001_3 - 0.02 15.0 0.0 0.78 9.9 0.1 2.4 1 1 1 2 2 2 0 Pleckstrin homology domain APG6 PF04111.10 001012815.1_23525001_3 - 0.068 12.4 2.0 0.13 11.5 2.0 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Golgin_A5 PF09787.7 001012815.1_23525001_3 - 0.19 11.0 4.2 0.3 10.4 4.2 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 GPS2_interact PF15784.3 001012815.1_23525001_3 - 0.22 12.1 3.8 0.62 10.7 3.8 1.7 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain FlxA PF14282.4 001012815.1_23525001_3 - 0.5 10.3 5.6 1.6 8.7 5.6 1.8 1 0 0 1 1 1 0 FlxA-like protein SecE PF00584.18 001302188.1_23521001_1 - 8.4e-15 54.3 0.1 1.4e-14 53.6 0.1 1.4 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex CHD5 PF04420.12 001079497.1_23524001_3 - 8.3e-36 123.1 0.9 1.3e-35 122.5 0.9 1.2 1 0 0 1 1 1 1 CHD5-like protein DUF1043 PF06295.10 001079497.1_23524001_3 - 0.084 12.7 2.7 0.14 12.0 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) DUF2203 PF09969.7 001079497.1_23524001_3 - 0.3 11.7 1.5 2.5 8.7 0.6 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) MCU PF04678.11 001079497.1_23524001_3 - 1.2 9.2 4.8 4.1 7.4 4.8 1.7 1 1 0 1 1 1 0 Mitochondrial calcium uniporter Chisel PF15355.4 001302190.1_23522001_3 - 3e-48 161.8 3.7 4e-48 161.5 3.7 1.1 1 0 0 1 1 1 1 Stretch-responsive small skeletal muscle X protein, Chisel zf-Tim10_DDP PF02953.13 001302195.1_23521001_2 - 1.1e-26 92.1 1.1 1.4e-26 91.8 1.1 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger PBP_GOBP PF01395.20 001302195.1_23521001_2 - 0.19 11.8 3.0 1.9 8.5 0.1 2.1 1 1 1 2 2 2 0 PBP/GOBP family Ribosomal_S24e PF01282.17 001277342.1_23522001_2 - 1.4e-45 153.1 0.5 2.4e-45 152.3 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e DUF1681 PF07933.12 001012837.1_23524001_1 - 9.8e-57 190.7 0.0 1.4e-56 190.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Pentapeptide PF00805.20 001012839.1_23527001_3 - 1.1e-35 120.7 23.2 3.7e-12 45.5 1.9 4.9 2 2 2 4 4 4 4 Pentapeptide repeats (8 copies) BTB_2 PF02214.20 001012839.1_23527001_3 - 4.8e-20 71.6 0.0 8.6e-20 70.8 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Pentapeptide_4 PF13599.4 001012839.1_23527001_3 - 1.7e-19 69.5 0.5 2.2e-09 37.1 0.0 3.7 2 1 2 4 4 4 3 Pentapeptide repeats (9 copies) KHA PF11834.6 001012839.1_23527001_3 - 6.4e-18 64.5 0.0 1e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 KHA, dimerisation domain of potassium ion channel Pentapeptide_3 PF13576.4 001012839.1_23527001_3 - 3.3e-13 49.4 0.1 3.1e-05 23.9 0.0 4.9 4 1 0 4 4 4 3 Pentapeptide repeats (9 copies) BTB_3 PF16017.3 001012839.1_23527001_3 - 0.00014 21.8 0.0 0.00026 20.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.29 001012839.1_23527001_3 - 0.00039 20.5 0.0 0.00079 19.5 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain CUE PF02845.14 001277349.1_23523001_2 - 0.0034 16.9 0.0 0.0068 15.9 0.0 1.5 1 0 0 1 1 1 1 CUE domain RRM_1 PF00076.20 001277358.1_23523001_3 - 1e-21 76.4 0.2 1.6e-21 75.8 0.2 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001277358.1_23523001_3 - 4.8e-09 35.7 0.0 8.2e-09 35.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.21 001277358.1_23523001_3 - 5.8e-05 22.9 2.0 0.00012 21.8 2.0 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.4 001277358.1_23523001_3 - 0.03 14.2 0.9 0.057 13.3 0.9 1.4 1 0 0 1 1 1 0 Zinc knuckle SET_assoc PF11767.6 001277358.1_23523001_3 - 0.03 13.8 0.0 0.069 12.7 0.0 1.5 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated RRM_7 PF16367.3 001277358.1_23523001_3 - 0.032 14.2 0.0 0.071 13.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif BRAP2 PF07576.10 001277358.1_23523001_3 - 0.032 14.3 0.0 0.057 13.5 0.0 1.3 1 0 0 1 1 1 0 BRCA1-associated protein 2 RRM_occluded PF16842.3 001277358.1_23523001_3 - 0.093 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif RAWUL PF16207.3 001277361.1_23524001_1 - 1.1e-12 48.2 2.5 2e-12 47.5 0.0 2.6 3 0 0 3 3 3 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.4 001277361.1_23524001_1 - 2e-09 37.0 10.8 2e-09 37.0 10.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001277361.1_23524001_1 - 1.8e-07 30.8 11.5 1.8e-07 30.8 11.5 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001277361.1_23524001_1 - 7.6e-06 25.7 10.9 6.8e-05 22.7 8.7 2.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001277361.1_23524001_1 - 0.00033 20.6 10.4 0.00033 20.6 10.4 3.2 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 001277361.1_23524001_1 - 0.0007 19.7 9.5 0.0007 19.7 9.5 2.5 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 001277361.1_23524001_1 - 0.0011 18.7 10.8 0.0011 18.7 10.8 3.1 3 1 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 001277361.1_23524001_1 - 0.0033 17.1 9.0 0.0033 17.1 9.0 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.6 001277361.1_23524001_1 - 0.0094 15.6 7.1 0.02 14.6 7.1 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.3 001277361.1_23524001_1 - 0.017 15.1 5.6 0.017 15.1 5.6 3.1 3 0 0 3 3 3 0 zinc RING finger of MSL2 zf-rbx1 PF12678.5 001277361.1_23524001_1 - 0.025 14.7 7.4 0.096 12.9 7.4 2.0 1 0 0 1 1 1 0 RING-H2 zinc finger domain zinc-ribbons_6 PF07191.10 001277361.1_23524001_1 - 0.59 10.0 10.3 1.2 9.1 6.0 2.9 2 0 0 2 2 2 0 zinc-ribbons Zn_Tnp_IS1595 PF12760.5 001277361.1_23524001_1 - 1.2 9.0 8.3 2.6 8.0 0.0 2.9 2 1 0 2 2 2 0 Transposase zinc-ribbon domain zf-RING_6 PF14835.4 001277361.1_23524001_1 - 1.3 8.8 9.4 0.16 11.7 4.2 2.2 2 0 0 2 2 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 001277361.1_23524001_1 - 8.8 6.2 18.6 0.046 13.5 8.0 2.7 3 0 0 3 3 2 0 Prokaryotic RING finger family 4 DPCD PF14913.4 001277366.1_23522001_2 - 2e-90 301.1 0.5 2.3e-90 300.9 0.5 1.0 1 0 0 1 1 1 1 DPCD protein family Mad3_BUB1_I PF08311.10 001012870.1_23529001_3 - 4.3e-36 123.5 0.0 2.7e-35 120.9 0.0 2.2 2 0 0 2 2 2 1 Mad3/BUB1 homology region 1 Pkinase PF00069.23 001012870.1_23529001_3 - 1.3e-16 60.6 0.0 2.7e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001012870.1_23529001_3 - 2.8e-08 33.2 0.0 4.9e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase AAA_23 PF13476.4 001012870.1_23529001_3 - 1.6 9.1 10.3 0.39 11.1 4.3 2.3 2 0 0 2 2 2 0 AAA domain PHF5 PF03660.12 001277376.1_23522001_1 - 1.5e-48 163.2 13.9 2.1e-48 162.7 13.9 1.2 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.11 001277376.1_23522001_1 - 0.29 8.8 7.0 0.35 8.5 7.0 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Runt PF00853.17 205227.1_23524001_1 - 8.7e-73 241.9 0.1 1.3e-72 241.4 0.1 1.2 1 0 0 1 1 1 1 Runt domain RunxI PF08504.9 205227.1_23524001_1 - 1.5e-42 144.2 4.5 3.9e-42 142.8 4.5 1.8 1 0 0 1 1 1 1 Runx inhibition domain DUF1639 PF07797.12 205227.1_23524001_3 - 0.14 12.0 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1639) WD40 PF00400.30 001079744.1_23524001_1 - 1.6e-09 38.1 9.8 0.00041 21.0 0.0 5.8 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001079744.1_23524001_1 - 0.0076 16.4 0.0 3 8.1 0.0 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Itfg2 PF15907.3 001079744.1_23524001_1 - 0.019 14.0 0.1 0.11 11.5 0.0 2.0 1 1 1 2 2 2 0 Integrin-alpha FG-GAP repeat-containing protein 2 Ras PF00071.20 001277380.1_23522001_1 - 1.6e-32 112.2 0.0 3.8e-32 111.0 0.0 1.6 1 1 0 1 1 1 1 Ras family Roc PF08477.11 001277380.1_23522001_1 - 5.5e-14 52.3 0.0 1.6e-13 50.8 0.0 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001277380.1_23522001_1 - 0.006 15.9 0.1 0.035 13.4 0.0 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family DUF258 PF03193.14 001277380.1_23522001_1 - 0.018 14.8 0.0 0.68 9.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001277380.1_23522001_1 - 0.031 13.7 0.0 0.051 13.0 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.4 001277380.1_23522001_1 - 0.077 13.2 0.0 0.2 11.9 0.0 1.7 1 1 1 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.21 001277380.1_23522001_1 - 0.11 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.4 001277380.1_23522001_1 - 0.12 12.8 0.1 0.29 11.5 0.1 1.7 1 1 0 1 1 1 0 AAA domain APA3_viroporin PF11289.6 001277380.1_23522001_2 - 0.057 12.8 1.1 0.077 12.4 1.1 1.1 1 0 0 1 1 1 0 Coronavirus accessory protein 3a Glutaredoxin PF00462.22 001277384.1_23523001_3 - 3e-39 132.9 0.1 5e-17 61.8 0.0 3.4 3 0 0 3 3 3 3 Glutaredoxin Thioredoxin PF00085.18 001277384.1_23523001_3 - 2.2e-20 72.4 1.8 3.9e-20 71.6 0.3 2.1 3 0 0 3 3 3 1 Thioredoxin Thioredoxin_2 PF13098.4 001277384.1_23523001_3 - 4.3e-08 33.4 0.2 3.1e-07 30.7 0.1 2.4 2 1 0 2 2 2 1 Thioredoxin-like domain DIM1 PF02966.14 001277384.1_23523001_3 - 3.9e-07 29.8 0.0 8.3e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 Mitosis protein DIM1 Phosducin PF02114.14 001277384.1_23523001_3 - 1.6e-05 23.9 0.0 2.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Phosducin SH3BGR PF04908.13 001277384.1_23523001_3 - 5.3e-05 23.2 0.0 0.29 11.2 0.0 2.6 2 0 0 2 2 2 2 SH3-binding, glutamic acid-rich protein TraF PF13728.4 001277384.1_23523001_3 - 0.00048 19.9 1.1 0.086 12.5 0.3 2.6 3 0 0 3 3 3 1 F plasmid transfer operon protein OST3_OST6 PF04756.11 001277384.1_23523001_3 - 0.0021 17.3 0.1 0.0037 16.5 0.1 1.4 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.4 001277384.1_23523001_3 - 0.0036 17.5 0.1 0.55 10.5 0.0 3.3 2 1 1 3 3 3 1 Thioredoxin-like HyaE PF07449.9 001277384.1_23523001_3 - 0.0045 16.8 0.1 0.074 12.9 0.2 2.7 2 1 2 4 4 4 1 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.4 001277384.1_23523001_3 - 0.046 13.4 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin TrbC_Ftype PF09673.8 001277384.1_23523001_3 - 0.052 13.5 0.2 0.11 12.4 0.2 1.5 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein TMEM164 PF14808.4 001012886.1_23527001_1 - 4.4e-117 389.8 6.4 6.2e-117 389.3 6.4 1.2 1 0 0 1 1 1 1 TMEM164 family V-SNARE PF05008.13 001277401.1_23522001_2 - 1.5e-24 86.0 0.3 1.5e-24 86.0 0.3 2.1 3 0 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.6 001277401.1_23522001_2 - 3e-21 75.3 7.5 1.8e-20 72.8 6.2 2.4 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.11 001277401.1_23522001_2 - 0.00088 19.0 1.0 0.0037 17.0 0.2 2.1 2 0 0 2 2 2 1 Sec20 Laminin_II PF06009.10 001277401.1_23522001_2 - 0.0022 17.9 0.3 0.1 12.5 0.0 2.2 2 0 0 2 2 2 1 Laminin Domain II DUF1664 PF07889.10 001277401.1_23522001_2 - 0.0031 17.4 1.2 0.1 12.4 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) Peptidase_S46 PF10459.7 001277401.1_23522001_2 - 0.03 12.9 3.2 0.037 12.5 3.2 1.0 1 0 0 1 1 1 0 Peptidase S46 SKA2 PF16740.3 001277401.1_23522001_2 - 0.1 12.3 0.4 0.1 12.3 0.4 2.3 2 2 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Exonuc_VII_L PF02601.13 001277401.1_23522001_2 - 0.32 10.4 8.6 1.5 8.2 8.6 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit DegQ PF08181.9 001277401.1_23522001_2 - 0.64 10.0 3.1 1.2 9.2 2.1 1.9 2 0 0 2 2 2 0 DegQ (SacQ) family DUF241 PF03087.12 001277401.1_23522001_2 - 4 7.1 11.6 0.12 12.1 1.2 2.5 1 1 2 3 3 3 0 Arabidopsis protein of unknown function 7tm_1 PF00001.19 001305214.1_23523001_1 - 1.3e-47 162.1 21.5 3.3e-47 160.9 21.5 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001305214.1_23523001_1 - 6.2e-05 22.4 18.0 8.2e-05 22.0 18.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx CRPA PF05745.9 001305214.1_23523001_1 - 0.62 9.9 3.3 0.47 10.3 0.3 2.1 2 0 0 2 2 2 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Hormone_2 PF00123.18 001080104.1_23522001_1 - 1.5e-12 47.1 3.8 5.8e-09 35.6 0.1 3.3 3 0 0 3 3 3 3 Peptide hormone Lipoprotein_10 PF03202.11 001080104.1_23522001_1 - 0.14 12.5 1.3 23 5.3 0.3 2.6 2 1 1 3 3 3 0 Putative mycoplasma lipoprotein, C-terminal region TPR_17 PF13431.4 001277412.1_23523001_3 - 4e-07 29.8 2.3 0.16 12.3 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 001277412.1_23523001_3 - 2e-06 28.1 3.8 0.2 12.1 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.26 001277412.1_23523001_3 - 8.7e-05 22.1 13.1 0.31 10.8 0.1 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.4 001277412.1_23523001_3 - 0.00093 19.7 6.5 31 5.6 2.9 4.8 4 2 1 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.4 001277412.1_23523001_3 - 0.0032 17.4 2.5 1.7 8.9 0.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.15 001277412.1_23523001_3 - 0.0037 17.1 17.2 1 9.5 0.1 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.5 001277412.1_23523001_3 - 0.19 11.8 6.8 1.1 9.4 0.2 3.6 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Sec15 PF04091.10 001012905.1_23526001_1 - 8.5e-104 347.2 6.1 8.5e-104 347.2 6.1 1.7 2 0 0 2 2 2 1 Exocyst complex subunit Sec15-like AKAP7_NLS PF10469.7 001012905.1_23526001_1 - 0.013 15.2 0.3 0.013 15.2 0.3 2.6 3 0 0 3 3 3 0 AKAP7 2'5' RNA ligase-like domain Sec8_exocyst PF04048.12 001012905.1_23526001_1 - 0.023 14.5 0.5 0.13 12.0 0.5 2.3 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain HSA PF07529.11 001012905.1_23526001_1 - 0.08 13.1 2.1 0.32 11.2 0.3 2.6 2 0 0 2 2 2 0 HSA COG5 PF10392.7 001012905.1_23526001_1 - 0.14 12.2 6.4 0.049 13.7 0.6 3.0 2 1 1 3 3 3 0 Golgi transport complex subunit 5 DUF883 PF05957.11 001012905.1_23526001_1 - 0.16 12.4 1.8 12 6.4 0.2 3.5 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) COG2 PF06148.9 001012905.1_23526001_1 - 2.8 7.9 8.9 0.86 9.6 2.6 3.0 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 I_LWEQ PF01608.15 001012905.1_23526001_1 - 7.2 6.7 8.7 3.8 7.6 0.7 3.2 3 0 0 3 3 3 0 I/LWEQ domain RPEL PF02755.13 001080715.1_23526001_3 - 2.1e-18 65.3 6.6 9.7e-07 28.2 0.0 3.5 3 0 0 3 3 3 3 RPEL repeat SAP PF02037.25 001080715.1_23526001_3 - 2e-10 40.1 0.1 2e-10 40.1 0.1 2.3 3 0 0 3 3 3 1 SAP domain IncA PF04156.12 001080715.1_23526001_3 - 0.16 11.6 9.6 0.15 11.7 0.1 2.6 2 0 0 2 2 2 0 IncA protein EF-hand_1 PF00036.30 001080865.1_23523001_3 - 1.4e-14 52.3 0.3 0.0011 18.3 0.0 5.2 5 1 0 5 5 5 3 EF hand EF-hand_8 PF13833.4 001080865.1_23523001_3 - 8e-14 51.0 0.6 3.6e-10 39.3 0.0 3.9 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.4 001080865.1_23523001_3 - 1.5e-11 43.1 0.1 0.0013 18.3 0.0 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.4 001080865.1_23523001_3 - 6.2e-10 39.3 0.1 0.0011 19.3 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 001080865.1_23523001_3 - 9e-10 37.5 1.5 0.0089 15.4 0.1 3.6 4 0 0 4 4 4 3 EF hand V-set PF07686.15 001305578.1_23528001_1 - 7.9e-13 48.4 0.3 1.6e-12 47.4 0.3 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 001305578.1_23528001_1 - 2.8e-05 24.1 0.4 0.00033 20.6 0.4 2.4 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001305578.1_23528001_1 - 0.00042 20.2 0.0 0.00075 19.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001305578.1_23528001_1 - 0.001 19.5 0.3 0.0034 17.8 0.3 1.9 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001305578.1_23528001_1 - 0.0042 17.3 0.5 0.015 15.5 0.5 2.0 1 0 0 1 1 1 1 Immunoglobulin domain C2 PF00168.28 001012929.1_23529001_1 - 3.3e-33 113.9 2.5 1.6e-16 60.4 0.0 3.2 2 1 0 2 2 2 2 C2 domain RasGAP PF00616.17 001012929.1_23529001_1 - 7.5e-27 94.3 0.3 7.6e-17 61.6 0.0 2.9 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase PH PF00169.27 001012929.1_23529001_1 - 8.9e-16 58.2 0.7 8.9e-16 58.2 0.7 2.5 2 0 0 2 2 2 1 PH domain BTK PF00779.17 001012929.1_23529001_1 - 4.5e-13 48.6 2.5 9.7e-13 47.6 2.5 1.6 1 0 0 1 1 1 1 BTK motif CEP76-C2 PF15627.4 001012929.1_23529001_1 - 0.00053 19.5 0.1 0.64 9.4 0.0 2.5 2 0 0 2 2 2 2 CEP76 C2 domain PH_8 PF15409.4 001012929.1_23529001_1 - 0.015 15.4 0.1 0.042 14.0 0.1 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain V-set PF07686.15 001305579.1_23528001_1 - 7.8e-13 48.4 0.3 1.6e-12 47.4 0.3 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 001305579.1_23528001_1 - 2.8e-05 24.1 0.4 0.00032 20.7 0.4 2.4 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001305579.1_23528001_1 - 0.00042 20.2 0.0 0.00073 19.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001305579.1_23528001_1 - 0.001 19.5 0.3 0.0033 17.9 0.3 1.9 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001305579.1_23528001_1 - 0.0042 17.3 0.5 0.015 15.5 0.5 2.0 1 0 0 1 1 1 1 Immunoglobulin domain Fzo_mitofusin PF04799.11 001012931.2_23528001_1 - 8e-75 249.6 5.5 8e-75 249.6 5.5 2.4 2 1 1 3 3 3 1 fzo-like conserved region Dynamin_N PF00350.21 001012931.2_23528001_1 - 1.8e-23 83.3 0.0 1.8e-23 83.3 0.0 3.3 3 1 1 4 4 4 1 Dynamin family MMR_HSR1 PF01926.21 001012931.2_23528001_1 - 4.1e-07 30.0 0.6 1.1e-06 28.5 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase Apolipoprotein PF01442.16 001012931.2_23528001_1 - 0.085 12.6 9.7 0.14 12.0 0.4 2.4 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Microvir_H PF04687.10 001012931.2_23528001_1 - 0.34 10.1 1.6 0.82 8.9 1.6 1.5 1 0 0 1 1 1 0 Microvirus H protein (pilot protein) AAA_23 PF13476.4 001012931.2_23528001_1 - 0.49 10.7 16.2 11 6.3 3.6 3.3 3 0 0 3 3 3 0 AAA domain Paralemmin PF03285.13 001012931.2_23528001_1 - 1.4 8.3 8.7 0.017 14.6 0.9 1.7 2 0 0 2 2 2 0 Paralemmin Synaptobrevin PF00957.19 001012931.2_23528001_1 - 1.5 8.6 6.3 0.27 10.9 2.0 2.1 2 0 0 2 2 2 0 Synaptobrevin Exonuc_VII_L PF02601.13 001012931.2_23528001_1 - 2.6 7.4 8.3 2.6 7.4 0.5 2.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit CLZ PF16526.3 001012931.2_23528001_1 - 4.2 7.7 9.9 3.1 8.1 0.2 3.4 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Tup_N PF08581.8 001012931.2_23528001_1 - 7.4 6.8 12.2 7.5 6.8 0.2 3.5 3 0 0 3 3 3 0 Tup N-terminal UQ_con PF00179.24 001080883.1_23525001_1 - 7.3e-50 168.1 0.0 1.1e-49 167.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme BAH PF01426.16 001012953.1_23528001_2 - 6.2e-35 119.5 0.7 1.6e-34 118.2 0.7 1.7 1 1 0 1 1 1 1 BAH domain ELM2 PF01448.22 001012953.1_23528001_2 - 5.9e-13 49.2 0.2 2.7e-12 47.1 0.0 2.3 2 0 0 2 2 2 1 ELM2 domain GATA PF00320.25 001012953.1_23528001_2 - 3.2e-09 36.1 10.0 7.7e-09 34.9 10.0 1.7 1 0 0 1 1 1 1 GATA zinc finger Myb_DNA-binding PF00249.29 001012953.1_23528001_2 - 1.6e-05 24.8 0.1 4e-05 23.5 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.3 001012953.1_23528001_2 - 0.028 14.1 0.1 0.028 14.1 0.1 1.7 2 0 0 2 2 2 0 Myb DNA-binding like TNF PF00229.16 001024578.1_23523001_1 - 3.4e-36 123.8 0.1 5.2e-36 123.2 0.1 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family DNA_methylase PF00145.15 001024831.3_23524001_3 - 4e-42 144.6 0.0 5.5e-42 144.2 0.0 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase MTS PF05175.12 001024831.3_23524001_3 - 0.0064 15.9 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Sulfotransfer_1 PF00685.25 001312678.1_23522001_1 - 2.1e-85 286.3 0.0 2.5e-85 286.1 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001312678.1_23522001_1 - 1.9e-05 25.1 0.4 0.0042 17.4 0.1 2.5 3 0 0 3 3 3 2 Sulfotransferase family Ribosomal_S10 PF00338.20 001030053.2_23523001_2 - 1.1e-16 60.8 0.2 1.6e-16 60.2 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e T-box PF00907.20 001030537.1_23525001_1 - 1.6e-81 272.8 0.2 2.6e-81 272.1 0.2 1.3 1 0 0 1 1 1 1 T-box Tetraspannin PF00335.18 001030339.2_23526001_2 - 2.9e-44 151.3 11.9 5.5e-44 150.4 11.9 1.5 1 0 0 1 1 1 1 Tetraspanin family Homeobox PF00046.27 205386.1_23524001_3 - 7.5e-20 70.4 1.9 1.7e-19 69.3 1.9 1.6 1 0 0 1 1 1 1 Homeobox domain Ig_2 PF13895.4 001318404.1_23522001_3 - 0.011 15.9 0.2 0.025 14.8 0.2 1.6 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.15 001318404.1_23522001_3 - 0.024 14.6 1.0 0.076 13.0 0.0 2.2 2 1 1 3 3 3 0 Immunoglobulin V-set domain Ig_3 PF13927.4 001318404.1_23522001_3 - 0.036 14.6 2.8 1.5 9.3 1.6 2.7 2 1 0 2 2 2 0 Immunoglobulin domain DSPc PF00782.18 001318409.1_23527001_2 - 2.5e-42 143.7 0.0 3.7e-42 143.2 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.18 001318409.1_23527001_2 - 2.2e-11 44.1 0.0 3.6e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain Y_phosphatase PF00102.25 001318409.1_23527001_2 - 0.0024 17.3 0.0 0.0039 16.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.10 001318409.1_23527001_2 - 0.039 14.1 0.0 0.079 13.1 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain PTPlike_phytase PF14566.4 001318409.1_23527001_2 - 0.15 12.0 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate 7tm_2 PF00002.22 001101035.1_23524001_1 - 1.7e-81 273.0 20.3 2.3e-81 272.6 20.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001101035.1_23524001_1 - 4.2e-15 55.6 4.0 1e-14 54.4 4.0 1.7 1 0 0 1 1 1 1 Hormone receptor domain Dicty_CAR PF05462.9 001101035.1_23524001_1 - 0.0024 16.9 17.0 0.0037 16.3 17.0 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Ocular_alb PF02101.13 001101035.1_23524001_1 - 0.0089 14.8 8.1 0.013 14.3 8.1 1.2 1 0 0 1 1 1 1 Ocular albinism type 1 protein TMEM43 PF07787.10 001101035.1_23524001_1 - 3.8 6.7 6.1 0.63 9.3 1.9 1.7 2 0 0 2 2 2 0 Transmembrane protein 43 RRM_1 PF00076.20 001318418.1_23524001_1 - 1.3e-35 120.9 0.1 3.7e-17 61.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 PF11627.6 001318418.1_23524001_1 - 3.6e-19 68.4 27.3 3.6e-19 68.4 27.3 6.7 3 1 3 6 6 6 1 Nuclear factor hnRNPA1 RRM_7 PF16367.3 001318418.1_23524001_1 - 2.7e-11 43.3 0.1 4.7e-06 26.5 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.4 001318418.1_23524001_1 - 0.058 12.9 0.0 0.095 12.2 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MCLC PF05934.9 001030550.1_23523001_1 - 0.14 10.7 0.4 0.2 10.2 0.4 1.1 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) AAA_18 PF13238.4 001030550.1_23523001_3 - 5.6e-24 85.0 0.0 7.9e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 001030550.1_23523001_3 - 0.0011 19.0 0.0 0.0021 18.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.21 001030550.1_23523001_3 - 0.063 13.2 0.1 0.27 11.2 0.1 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase RNA_helicase PF00910.20 001030550.1_23523001_3 - 0.13 12.5 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 RNA helicase BAG PF02179.14 001109692.1_23523001_2 - 1.8e-09 37.8 1.9 3.8e-09 36.7 1.9 1.5 1 1 0 1 1 1 1 BAG domain ubiquitin PF00240.21 001109692.1_23523001_2 - 1.4e-08 34.2 0.1 3.1e-08 33.1 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin family PHTB1_C PF14728.4 001109692.1_23523001_2 - 0.0029 16.6 1.2 0.0029 16.6 1.2 1.4 2 0 0 2 2 2 1 PTHB1 C-terminus SesA PF17107.3 001109692.1_23523001_2 - 0.018 15.1 2.2 0.032 14.3 2.2 1.3 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF342 PF03961.11 001109692.1_23523001_2 - 0.15 10.5 4.9 0.21 10.0 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Ubiquitin_2 PF14560.4 001109692.1_23523001_2 - 0.16 12.3 0.5 0.67 10.3 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin-like domain DASH_Duo1 PF08651.8 001109692.1_23523001_2 - 0.18 11.5 2.0 0.93 9.2 0.5 2.4 2 0 0 2 2 2 0 DASH complex subunit Duo1 TRPM_tetra PF16519.3 001109692.1_23523001_2 - 0.27 11.2 3.0 12 6.0 0.4 3.1 2 1 1 3 3 3 0 Tetramerisation domain of TRPM YPEB PF14620.4 001109692.1_23523001_2 - 0.49 9.5 4.5 0.21 10.8 2.0 1.5 2 0 0 2 2 2 0 YpeB sporulation MscS_porin PF12795.5 001109692.1_23523001_2 - 3 7.2 8.7 1.1 8.6 0.7 2.2 2 1 1 3 3 3 0 Mechanosensitive ion channel porin domain Seryl_tRNA_N PF02403.20 001109692.1_23523001_2 - 4.3 7.5 11.2 3.1 7.9 8.0 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain NTF2 PF02136.18 001030562.2_23522001_1 - 2.2e-32 112.0 0.6 6.1e-32 110.6 0.0 1.8 2 0 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain V-set PF07686.15 205436.1_23524001_1 - 3.2e-13 49.6 0.0 6.6e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 205436.1_23524001_1 - 3.1e-06 27.6 0.1 1e-05 25.9 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 205436.1_23524001_1 - 4.1e-06 26.7 0.1 3.3e-05 23.7 0.1 2.4 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 205436.1_23524001_1 - 0.0032 17.7 0.1 0.02 15.1 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 205436.1_23524001_1 - 0.0069 16.4 0.2 0.048 13.7 0.2 2.3 1 1 0 1 1 1 1 Immunoglobulin domain Spc7 PF08317.9 205436.1_23524001_1 - 0.46 9.2 49.4 0.12 11.1 24.8 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein HALZ PF02183.16 205436.1_23524001_1 - 0.72 10.0 15.2 1.7 8.8 3.8 3.3 3 0 0 3 3 3 0 Homeobox associated leucine zipper CKS PF01111.17 001112806.2_23522001_3 - 7.3e-38 128.5 1.2 1e-37 128.1 1.2 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit 7tm_1 PF00001.19 001318436.1_23524001_2 - 1.7e-49 168.4 9.2 2.5e-49 167.8 9.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001318436.1_23524001_2 - 3.5e-08 33.0 10.4 6.7e-08 32.1 10.4 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.7 001318436.1_23524001_2 - 1e-06 28.2 15.0 3.1e-05 23.3 15.0 2.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.7 001318436.1_23524001_2 - 4.1e-05 22.9 8.7 7.9e-05 22.0 8.7 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001318436.1_23524001_2 - 5.2e-05 23.0 6.1 5.2e-05 23.0 6.1 2.0 2 0 0 2 2 2 1 Olfactory receptor polyprenyl_synt PF00348.15 001318441.1_23523001_1 - 5.4e-20 71.4 0.1 8.3e-20 70.8 0.1 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase VirK PF06903.10 001318441.1_23523001_1 - 0.011 15.7 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 VirK protein ENTH PF01417.18 001030615.1_23527001_3 - 4.7e-45 152.5 0.0 9e-45 151.6 0.0 1.5 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.14 001030615.1_23527001_3 - 7.8e-05 21.7 0.0 0.00012 21.1 0.0 1.2 1 0 0 1 1 1 1 ANTH domain CHCH PF06747.11 001113759.1_23523001_1 - 9.6e-09 35.0 7.3 9.6e-09 35.0 7.3 2.2 2 0 0 2 2 2 1 CHCH domain DUF3796 PF12676.5 001113759.1_23523001_1 - 0.064 13.6 0.5 0.13 12.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3796) GCK PF07802.9 001113759.1_23523001_1 - 0.58 10.5 7.7 0.096 13.0 3.3 2.0 2 0 0 2 2 2 0 GCK domain DUF2205 PF10224.7 001114852.1_23526001_1 - 2.9e-26 91.1 3.9 5.5e-26 90.2 3.9 1.4 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) bZIP_1 PF00170.19 001114852.1_23526001_1 - 0.071 13.1 0.8 0.15 12.0 0.8 1.5 1 0 0 1 1 1 0 bZIP transcription factor IncA PF04156.12 001114852.1_23526001_1 - 0.091 12.4 3.4 0.15 11.7 3.4 1.2 1 0 0 1 1 1 0 IncA protein HALZ PF02183.16 001114852.1_23526001_1 - 0.24 11.5 7.6 0.69 10.0 1.8 2.7 1 1 1 2 2 2 0 Homeobox associated leucine zipper DUF972 PF06156.11 001114852.1_23526001_1 - 0.24 11.9 3.7 0.47 11.0 3.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) FlaC_arch PF05377.9 001114852.1_23526001_1 - 0.26 11.6 1.1 0.56 10.5 1.1 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) ZapB PF06005.10 001114852.1_23526001_1 - 1.2 9.5 6.5 2.2 8.7 6.5 1.4 1 0 0 1 1 1 0 Cell division protein ZapB Agouti PF05039.10 001115079.1_23521001_3 - 1.1e-23 83.6 11.5 1.5e-23 83.1 11.5 1.2 1 0 0 1 1 1 1 Agouti protein DivIC PF04977.13 001115079.1_23521001_3 - 0.18 11.4 0.2 0.32 10.7 0.2 1.3 1 0 0 1 1 1 0 Septum formation initiator Topoisom_bac PF01131.18 001030636.2_23528001_1 - 1.1e-114 383.5 0.0 3e-114 382.1 0.0 1.6 2 0 0 2 2 2 1 DNA topoisomerase zf-GRF PF06839.10 001030636.2_23528001_1 - 7e-36 121.9 22.2 4.2e-20 71.4 5.1 3.1 3 0 0 3 3 3 2 GRF zinc finger Toprim PF01751.20 001030636.2_23528001_1 - 6.7e-17 61.5 0.0 1.6e-16 60.2 0.0 1.7 1 0 0 1 1 1 1 Toprim domain zf-C4_Topoisom PF01396.17 001030636.2_23528001_1 - 1.4e-12 47.0 1.9 1.4e-12 47.0 1.9 3.2 3 0 0 3 3 3 1 Topoisomerase DNA binding C4 zinc finger zf-C2H2_10 PF16588.3 001030636.2_23528001_1 - 0.017 14.7 1.5 0.052 13.1 1.5 1.9 1 0 0 1 1 1 0 C2H2 zinc-finger Nrf1_DNA-bind PF10491.7 001030646.1_23525001_1 - 2.3e-116 386.7 0.1 3.6e-116 386.1 0.1 1.3 1 0 0 1 1 1 1 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Nrf1_activ_bdg PF10492.7 001030646.1_23525001_1 - 0.0014 19.1 6.8 0.0014 19.1 6.8 5.5 3 2 2 5 5 5 1 Nrf1 activator activation site binding domain DUF5008 PF16400.3 001030646.1_23525001_1 - 0.084 12.8 0.0 0.28 11.2 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5008) DUF3459 PF11941.6 001030646.1_23525001_1 - 0.16 12.2 0.8 0.56 10.4 0.8 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3459) Peptidase_M23 PF01551.20 001030646.1_23525001_1 - 0.52 10.4 3.2 0.85 9.7 1.0 2.3 1 1 1 2 2 2 0 Peptidase family M23 Pro_isomerase PF00160.19 001030653.1_23526001_3 - 2.1e-51 174.2 0.1 4.1e-51 173.3 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.10 001030653.1_23526001_3 - 7.7e-05 22.0 0.6 7.7e-05 22.0 0.6 2.7 2 1 0 2 2 2 1 Rtf2 RING-finger zf-NOSIP PF15906.3 001030653.1_23526001_3 - 0.00078 19.4 0.0 0.0025 17.8 0.0 1.9 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein U-box PF04564.13 001030653.1_23526001_3 - 0.0033 17.4 0.0 0.014 15.4 0.0 2.0 2 0 0 2 2 2 1 U-box domain Glycos_transf_1 PF00534.18 001030656.1_23526001_1 - 1.8e-20 73.1 0.0 2.7e-20 72.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.4 001030656.1_23526001_1 - 4.4e-15 56.2 0.0 7.2e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.4 001030656.1_23526001_1 - 7.3e-08 32.6 0.0 1.4e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 VWD PF00094.23 001318464.1_23529001_1 - 3.2e-118 391.3 17.6 7.8e-36 123.6 0.2 4.6 4 0 0 4 4 4 4 von Willebrand factor type D domain VWA PF00092.26 001318464.1_23529001_1 - 6.9e-92 306.3 10.7 2.4e-38 132.0 0.3 3.2 3 0 0 3 3 3 3 von Willebrand factor type A domain C8 PF08742.9 001318464.1_23529001_1 - 8.4e-55 183.0 59.1 1e-17 64.2 8.6 9.0 9 0 0 9 9 9 4 C8 domain VWA_2 PF13519.4 001318464.1_23529001_1 - 8.2e-31 106.7 1.9 1.7e-11 44.6 0.0 3.3 3 0 0 3 3 3 3 von Willebrand factor type A domain TIL PF01826.15 001318464.1_23529001_1 - 8.5e-27 93.1 108.8 1e-11 44.7 18.3 20.7 19 4 3 22 22 22 5 Trypsin Inhibitor like cysteine rich domain VWC PF00093.16 001318464.1_23529001_1 - 1.9e-08 34.3 60.0 2.4e-06 27.7 14.7 21.3 14 4 4 18 18 18 6 von Willebrand factor type C domain Pacifastin_I PF05375.11 001318464.1_23529001_1 - 0.00054 19.5 5.4 0.00054 19.5 5.4 12.9 13 0 0 13 13 13 2 Pacifastin inhibitor (LCMII) Ank_2 PF12796.5 001130738.1_23525001_1 - 7.1e-47 157.8 9.8 8.4e-10 39.0 0.0 4.6 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.28 001130738.1_23525001_1 - 4e-30 102.8 4.6 1.5e-05 25.1 0.1 7.1 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.4 001130738.1_23525001_1 - 6.8e-26 90.2 1.6 2.4e-07 31.0 0.2 5.8 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.4 001130738.1_23525001_1 - 1.5e-25 88.7 4.3 8.5e-08 32.2 0.0 7.5 2 1 6 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.4 001130738.1_23525001_1 - 2.8e-24 82.4 3.0 0.00035 20.6 0.1 7.8 8 0 0 8 8 8 5 Ankyrin repeat Patatin PF01734.20 001130738.1_23525001_1 - 7e-19 68.6 1.8 4.8e-18 65.9 1.8 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase Bromodomain PF00439.23 001030674.1_23526001_1 - 1.3e-42 143.6 1.0 2.8e-21 75.2 0.1 2.4 2 0 0 2 2 2 2 Bromodomain BET PF17035.3 001030674.1_23526001_1 - 5.8e-29 99.9 0.2 5.8e-29 99.9 0.2 2.3 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation Sigma70_ner PF04546.11 001030674.1_23526001_1 - 0.0015 18.3 12.2 0.0015 18.3 12.2 2.0 2 0 0 2 2 2 1 Sigma-70, non-essential region DNA_pol_phi PF04931.11 001030674.1_23526001_1 - 0.0016 16.6 17.4 0.0016 16.6 17.4 2.1 2 0 0 2 2 2 1 DNA polymerase phi SLY PF12485.6 001030674.1_23526001_1 - 0.015 15.9 12.8 0.015 15.9 12.8 4.1 4 0 0 4 4 4 0 Lymphocyte signaling adaptor protein GCIP PF13324.4 001030674.1_23526001_1 - 0.03 13.8 7.8 0.057 12.9 7.8 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting SGT1 PF07093.9 001030674.1_23526001_1 - 0.31 9.3 12.7 0.64 8.3 12.7 1.5 1 0 0 1 1 1 0 SGT1 protein Astro_capsid_p PF12226.6 001030674.1_23526001_1 - 6.1 5.8 13.9 9.8 5.1 13.9 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF2464 PF10240.7 001030677.1_23529001_2 - 7.2e-81 271.2 0.0 1.3e-80 270.3 0.0 1.4 2 0 0 2 2 2 1 Multivesicular body subunit 12 ABC_membrane PF00664.21 001135968.1_23524001_1 - 1.5e-42 146.0 0.2 1.9e-42 145.7 0.2 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 001135968.1_23524001_1 - 5.6e-32 111.0 0.0 1e-31 110.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_ATPase PF09818.7 001135968.1_23524001_1 - 7.2e-05 21.6 0.0 0.00015 20.6 0.0 1.6 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_16 PF13191.4 001135968.1_23524001_1 - 0.00081 19.7 0.7 0.00081 19.7 0.7 2.4 2 2 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.17 001135968.1_23524001_1 - 0.0022 17.4 0.0 0.0047 16.3 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.4 001135968.1_23524001_1 - 0.0024 17.4 0.0 0.0058 16.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.4 001135968.1_23524001_1 - 0.0081 15.8 0.6 0.068 12.8 0.5 2.5 1 1 0 1 1 1 1 AAA domain AAA PF00004.27 001135968.1_23524001_1 - 0.012 15.9 0.0 1.4 9.2 0.1 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.4 001135968.1_23524001_1 - 0.013 15.0 0.4 0.076 12.4 0.4 2.3 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.4 001135968.1_23524001_1 - 0.023 14.8 0.0 0.11 12.6 0.0 2.1 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.13 001135968.1_23524001_1 - 0.04 12.7 0.0 0.062 12.1 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_33 PF13671.4 001135968.1_23524001_1 - 0.095 12.7 0.3 0.32 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain Erv26 PF04148.11 001135968.1_23524001_1 - 0.099 12.3 0.2 0.18 11.5 0.2 1.3 1 0 0 1 1 1 0 Transmembrane adaptor Erv26 AAA_5 PF07728.12 001135968.1_23524001_1 - 0.12 12.3 0.3 0.43 10.5 0.1 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.4 001135968.1_23524001_1 - 0.17 12.3 0.0 0.59 10.5 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.4 001135968.1_23524001_1 - 0.19 11.3 0.0 8.6 5.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Ifi-6-16 PF06140.11 001002856.1_23521001_3 - 1.2e-26 92.3 28.4 1.2e-26 92.3 28.4 1.7 1 1 1 2 2 2 1 Interferon-induced 6-16 family Ion_trans PF00520.29 001143931.1_23525001_1 - 8.8e-48 162.5 58.5 2.6e-31 108.6 24.1 2.1 2 0 0 2 2 2 2 Ion transport protein NIPSNAP PF07978.11 001030713.1_23525001_1 - 4.4e-37 126.3 1.3 1.1e-31 108.9 0.2 2.3 2 0 0 2 2 2 2 NIPSNAP Lactamase_B_2 PF12706.5 001030730.1_23525001_3 - 1.3e-38 132.4 0.0 1.9e-38 131.9 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.4 001030730.1_23525001_3 - 1.6e-13 50.7 0.0 2.5e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.25 001030730.1_23525001_3 - 0.0051 16.7 1.4 0.011 15.7 0.7 1.9 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Pkinase_Tyr PF07714.15 001030738.1_23526001_1 - 1.7e-24 86.4 0.0 2.9e-24 85.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001030738.1_23526001_1 - 4.6e-23 81.8 0.0 6.6e-23 81.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Death PF00531.20 001030738.1_23526001_1 - 0.0044 17.0 0.0 0.0093 16.0 0.0 1.5 1 0 0 1 1 1 1 Death domain Pkinase PF00069.23 001030738.1_23526001_2 - 3.6e-22 78.8 0.0 5.3e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001030738.1_23526001_2 - 6.4e-18 64.8 0.0 1e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase zf-Nse PF11789.6 102407.1_23522120_1 - 2.2e-19 68.9 2.3 3.6e-19 68.2 2.3 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.4 102407.1_23522120_1 - 6.5e-07 29.1 0.2 1.6e-06 27.9 0.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.10 102407.1_23522120_1 - 0.00012 21.4 4.1 0.00017 20.9 3.7 1.5 1 1 1 2 2 2 1 Rtf2 RING-finger U-box PF04564.13 102407.1_23522120_1 - 0.0086 16.1 0.1 0.023 14.7 0.1 1.7 1 1 0 1 1 1 1 U-box domain HalX PF08663.8 102407.1_23522120_1 - 0.072 13.2 2.9 0.12 12.6 2.9 1.3 1 0 0 1 1 1 0 HalX domain DHHA1 PF02272.17 102411.1_23522120_2 - 0.27 11.2 6.7 0.77 9.7 6.7 1.7 1 0 0 1 1 1 0 DHHA1 domain EF-hand_1 PF00036.30 102411.1_23522120_3 - 2.5e-31 104.7 13.1 1.2e-09 36.8 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.4 102411.1_23522120_3 - 6e-27 91.1 2.9 3.6e-09 35.7 0.1 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.4 102411.1_23522120_3 - 3e-24 85.2 8.5 6.1e-16 58.5 1.2 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 102411.1_23522120_3 - 3e-23 81.2 8.9 3.1e-13 49.2 0.9 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 102411.1_23522120_3 - 9.2e-22 75.4 10.2 1.1e-08 34.0 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.4 102411.1_23522120_3 - 5.7e-09 36.0 0.3 0.0015 18.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.7 102411.1_23522120_3 - 0.00027 21.1 0.0 0.053 13.7 0.0 2.2 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.11 102411.1_23522120_3 - 0.0062 16.3 0.0 0.6 9.9 0.0 2.3 2 1 0 2 2 2 1 Caleosin related protein EF-hand_4 PF12763.5 102411.1_23522120_3 - 0.0063 16.3 2.7 0.086 12.7 0.2 2.6 1 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Prefoldin_3 PF13758.4 102411.1_23522120_3 - 0.015 15.2 0.0 1.4 8.9 0.1 2.2 1 1 1 2 2 2 0 Prefoldin subunit DIMCO_N PF16844.3 102411.1_23522120_3 - 0.026 14.7 0.1 0.24 11.6 0.0 2.1 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor, N-terminal DUF3349 PF11829.6 102411.1_23522120_3 - 0.029 15.0 0.0 1.1 9.9 0.0 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3349) GPHH PF16905.3 102411.1_23522120_3 - 0.035 13.8 0.0 1.1 9.0 0.0 2.5 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated TerB PF05099.11 102411.1_23522120_3 - 0.043 13.6 0.2 2.8 7.8 0.0 2.4 2 1 0 2 2 2 0 Tellurite resistance protein TerB OST-HTH PF12872.5 102411.1_23522120_3 - 0.045 13.5 0.0 0.32 10.8 0.0 2.2 2 0 0 2 2 2 0 OST-HTH/LOTUS domain Dockerin_1 PF00404.16 102411.1_23522120_3 - 1.7 8.5 5.6 13 5.7 0.1 2.7 3 0 0 3 3 3 0 Dockerin type I repeat Ribosomal_L11_N PF03946.12 102416.1_23522120_1 - 2.4e-25 87.9 0.1 3.6e-25 87.4 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.17 102416.1_23522120_3 - 3.3e-18 65.8 0.1 5.5e-18 65.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ctf8 PF09696.8 102418.1_23523120_1 - 1.4e-06 28.5 0.7 0.00013 22.2 0.3 3.0 2 1 0 2 2 2 1 Ctf8 Ctf8 PF09696.8 102419.1_23523120_2 - 1.5e-06 28.5 0.7 0.00013 22.2 0.3 3.0 2 1 0 2 2 2 1 Ctf8 ICAP-1_inte_bdg PF10480.7 102745.1_23523120_2 - 2e-112 373.9 3.7 2.4e-112 373.6 3.7 1.1 1 0 0 1 1 1 1 Beta-1 integrin binding protein PID PF00640.21 102745.1_23523120_2 - 6.8e-06 26.0 0.0 1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) ICAP-1_inte_bdg PF10480.7 102745.1_23523120_3 - 5.6e-09 36.2 1.9 9.2e-09 35.4 1.9 1.3 1 0 0 1 1 1 1 Beta-1 integrin binding protein KRAB PF01352.25 103453.1_23526120_2 - 3.4e-07 29.7 1.8 7.7e-07 28.6 1.8 1.6 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.4 103453.1_23526120_3 - 1.5e-08 34.6 29.0 2.6e-06 27.5 2.4 5.2 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.24 103453.1_23526120_3 - 5e-08 32.8 35.9 6.7e-05 23.0 4.4 4.8 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 103453.1_23526120_3 - 2.6e-07 30.8 28.6 0.0045 17.6 2.9 5.1 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.4 103453.1_23526120_3 - 0.0018 18.0 15.5 0.033 14.0 2.2 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_8 PF15909.3 103453.1_23526120_3 - 0.12 12.5 13.5 0.027 14.6 2.0 3.1 2 1 1 3 3 3 0 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.8 103453.1_23526120_3 - 1.8 8.6 8.8 0.55 10.3 3.1 3.1 3 0 0 3 3 3 0 Zinc ribbon domain DUF4499 PF14934.4 104092.1_23524120_2 - 9.1e-23 80.3 1.9 9.1e-23 80.3 1.9 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4499) BLOC1_2 PF10046.7 102403.1_23523120_2 - 4.2e-34 116.6 8.9 5.6e-34 116.2 8.9 1.2 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 ParB PF08775.8 102403.1_23523120_2 - 0.062 13.6 2.0 0.11 12.9 2.0 1.3 1 0 0 1 1 1 0 ParB family XhlA PF10779.7 102403.1_23523120_2 - 5.9 7.0 7.0 4.9 7.3 0.3 2.9 3 0 0 3 3 3 0 Haemolysin XhlA Cupin_8 PF13621.4 130969.1_23523120_1 - 1.2e-33 116.8 0.1 1.6e-33 116.5 0.1 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.10 130969.1_23523120_1 - 3.6e-10 39.7 0.0 4.9e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.20 130969.1_23523120_1 - 0.012 16.0 0.0 0.02 15.2 0.0 1.3 1 0 0 1 1 1 0 JmjC domain, hydroxylase Cupin_8 PF13621.4 130969.1_23523120_2 - 0.00031 20.5 0.0 0.00042 20.1 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain UEV PF05743.11 102406.1_23523120_1 - 8.4e-09 35.2 0.0 1.3e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.8 102406.1_23523120_2 - 2.8e-28 97.5 0.1 4.9e-28 96.7 0.1 1.4 1 0 0 1 1 1 1 Vps23 core domain DUF3450 PF11932.6 102406.1_23523120_2 - 0.0005 19.3 8.3 0.00088 18.5 8.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) APG6 PF04111.10 102406.1_23523120_2 - 0.0006 19.2 4.8 0.00079 18.8 4.8 1.3 1 0 0 1 1 1 1 Autophagy protein Apg6 GPS2_interact PF15784.3 102406.1_23523120_2 - 0.013 16.0 7.7 0.032 14.8 7.8 1.6 1 1 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain Macoilin PF09726.7 102406.1_23523120_2 - 0.014 13.8 3.5 0.019 13.4 3.5 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF1640 PF07798.9 102406.1_23523120_2 - 0.023 14.6 8.6 0.023 14.6 7.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) IncA PF04156.12 102406.1_23523120_2 - 0.027 14.1 5.5 0.038 13.6 5.5 1.2 1 0 0 1 1 1 0 IncA protein ERM PF00769.17 102406.1_23523120_2 - 0.038 13.7 13.8 0.07 12.8 13.8 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family TBPIP PF07106.11 102406.1_23523120_2 - 0.047 13.3 7.6 0.073 12.7 7.6 1.4 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF3552 PF12072.6 102406.1_23523120_2 - 0.048 12.9 8.6 0.072 12.4 8.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Exonuc_VII_L PF02601.13 102406.1_23523120_2 - 0.055 12.9 1.5 0.066 12.6 1.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Fzo_mitofusin PF04799.11 102406.1_23523120_2 - 0.056 12.8 4.4 0.11 11.9 4.4 1.4 1 0 0 1 1 1 0 fzo-like conserved region SlyX PF04102.10 102406.1_23523120_2 - 0.064 13.7 12.4 0.064 13.8 3.1 3.1 2 1 1 3 3 3 0 SlyX Reo_sigmaC PF04582.10 102406.1_23523120_2 - 0.064 12.5 0.4 0.085 12.1 0.4 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF342 PF03961.11 102406.1_23523120_2 - 0.079 11.4 4.7 0.1 11.1 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Spc7 PF08317.9 102406.1_23523120_2 - 0.088 11.5 10.2 0.12 11.0 10.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Spc24 PF08286.9 102406.1_23523120_2 - 0.24 11.5 12.2 0.36 10.9 4.8 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF3782 PF12644.5 102406.1_23523120_2 - 0.24 11.4 5.9 4.2 7.4 0.0 3.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3782) DUF724 PF05266.12 102406.1_23523120_2 - 0.42 10.3 9.5 0.65 9.7 9.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FlaC_arch PF05377.9 102406.1_23523120_2 - 0.44 10.8 11.6 0.77 10.1 0.7 2.5 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Fib_alpha PF08702.8 102406.1_23523120_2 - 0.45 10.6 4.7 0.77 9.8 4.7 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.10 102406.1_23523120_2 - 0.5 10.2 4.8 0.87 9.5 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Spore_III_AB PF09548.8 102406.1_23523120_2 - 0.96 9.4 5.2 1.4 8.9 5.2 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Nsp1_C PF05064.11 102406.1_23523120_2 - 1 9.1 7.8 0.61 9.8 5.1 1.9 1 1 1 2 2 2 0 Nsp1-like C-terminal region Seryl_tRNA_N PF02403.20 102406.1_23523120_2 - 1.4 9.0 10.9 1.5 9.0 6.9 2.0 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain zf-CpG_bind_C PF12269.6 102406.1_23523120_2 - 1.4 8.5 4.7 2.8 7.5 4.7 1.5 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain DivIC PF04977.13 102406.1_23523120_2 - 1.4 8.6 13.5 1.7 8.4 2.2 2.6 1 1 1 2 2 2 0 Septum formation initiator NPV_P10 PF05531.10 102406.1_23523120_2 - 1.8 9.0 5.2 7.4 7.0 4.0 2.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4140 PF13600.4 102406.1_23523120_2 - 2.3 8.6 7.8 17 5.8 6.9 2.3 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) BRE1 PF08647.9 102406.1_23523120_2 - 2.7 8.0 17.4 1.5 8.8 13.6 2.0 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase HrpB7 PF09486.8 102406.1_23523120_2 - 3.8 7.8 10.3 0.39 10.9 5.7 1.6 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Prefoldin_2 PF01920.18 102406.1_23523120_2 - 4.2 7.2 14.9 2.4 8.0 2.9 2.3 1 1 1 2 2 2 0 Prefoldin subunit TMF_DNA_bd PF12329.6 102406.1_23523120_2 - 4.9 7.1 17.9 6.5 6.7 15.6 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Bap31 PF05529.10 102406.1_23523120_2 - 5 6.5 8.3 8.5 5.8 8.3 1.3 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Snapin_Pallidin PF14712.4 102406.1_23523120_2 - 7.7 6.9 13.4 0.69 10.3 2.0 2.7 2 1 1 3 3 3 0 Snapin/Pallidin Peptidase_C12 PF01088.19 131183.1_23524120_3 - 5.2e-71 238.6 0.0 6.3e-71 238.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Alpha-amylase PF00128.22 003250.2_23523120_3 - 0.016 14.6 0.0 0.022 14.2 0.0 1.1 1 0 0 1 1 1 0 Alpha amylase, catalytic domain Lectin_C PF00059.19 205429.2_23523001_1 - 3.2e-14 53.4 1.3 5.3e-14 52.7 1.3 1.4 1 0 0 1 1 1 1 Lectin C-type domain PT PF04886.10 001105689.1_16123001_1 - 3.6e-21 74.3 79.2 2.9e-12 45.8 38.1 2.3 1 1 1 2 2 2 2 PT repeat DUF3533 PF12051.6 001105689.1_16123001_1 - 0.019 13.8 1.1 0.023 13.5 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) PT PF04886.10 001105689.1_16123001_2 - 2.2e-21 75.0 76.4 3.1e-12 45.7 36.7 2.4 1 1 1 2 2 2 2 PT repeat FHA PF00498.24 001105689.1_16123001_2 - 0.0054 16.9 0.0 0.0095 16.1 0.0 1.4 1 0 0 1 1 1 1 FHA domain DUF4106 PF13388.4 001105689.1_16123001_2 - 0.0061 15.7 21.8 0.012 14.8 21.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4106) Pex14_N PF04695.11 001105689.1_16123001_2 - 0.5 10.9 10.9 0.82 10.2 10.9 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1387 PF07139.9 001105689.1_16123001_2 - 0.58 9.6 6.8 0.76 9.3 6.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) RP-C_C PF11800.6 001105689.1_16123001_2 - 1.6 8.6 5.6 2.3 8.1 5.6 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Trypan_PARP PF05887.9 001105689.1_16123001_2 - 6.7 6.6 11.4 11 6.0 11.4 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) MGC-24 PF05283.9 001105689.1_16123001_2 - 8.3 6.7 11.2 14 6.0 11.2 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin PT PF04886.10 001105689.1_16123001_3 - 1.3e-21 75.7 75.1 2.3e-12 46.1 34.0 2.3 1 1 1 2 2 2 2 PT repeat DUF4106 PF13388.4 001105689.1_16123001_3 - 0.17 10.9 23.5 0.31 10.1 23.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) V-set PF07686.15 001114746.1_16128001_2 - 2.6e-11 43.5 0.0 2.1e-10 40.6 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001114746.1_16128001_2 - 5.3e-09 36.4 0.1 0.0032 17.9 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain SPRY PF00622.26 001114746.1_16128001_2 - 7.9e-08 32.3 0.0 1.4e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 SPRY domain ig PF00047.23 001114746.1_16128001_2 - 9.3e-07 28.8 0.3 0.023 14.7 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001114746.1_16128001_2 - 1.7e-06 27.9 0.4 1.2e-05 25.1 0.2 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain I-set PF07679.14 001114746.1_16128001_2 - 1.9e-05 24.5 0.0 0.0089 15.9 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin I-set domain LRR_8 PF13855.4 001252462.1_16124001_1 - 3.2e-21 74.7 22.7 3.6e-11 42.5 7.4 3.6 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 001252462.1_16124001_1 - 8.5e-12 44.9 30.4 2.1e-06 27.8 0.3 5.7 5 1 0 6 6 6 4 Leucine Rich repeats (2 copies) LRRNT PF01462.16 001252462.1_16124001_1 - 2e-06 27.2 5.1 5.4e-06 25.8 5.1 1.8 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 001252462.1_16124001_1 - 6.7e-06 25.7 23.0 3.3 8.4 0.0 8.1 7 1 0 7 7 7 3 Leucine Rich Repeat LRR_5 PF13306.4 001252462.1_16124001_1 - 0.0096 15.8 0.6 0.45 10.4 0.2 2.5 1 1 1 2 2 2 1 Leucine rich repeats (6 copies) LRRCT PF01463.22 001252462.1_16124001_1 - 0.054 13.9 0.2 0.26 11.8 0.2 2.2 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain UPF0233 PF06781.10 001252462.1_16124001_1 - 0.092 12.7 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0233) LRR_6 PF13516.4 001252462.1_16124001_1 - 0.12 12.4 21.1 8 6.7 0.1 6.2 6 0 0 6 6 6 0 Leucine Rich repeat zf-C3HC4_4 PF15227.4 001114711.1_16126001_2 - 2.3e-12 46.7 14.2 2.3e-12 46.7 14.2 3.0 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 001114711.1_16126001_2 - 1.4e-08 34.4 8.5 1.4e-08 34.4 8.5 3.1 2 1 1 3 3 3 1 RING-type zinc-finger zf-B_box PF00643.22 001114711.1_16126001_2 - 2.9e-08 33.6 8.5 2.9e-08 33.6 8.5 4.0 4 1 0 4 4 3 1 B-box zinc finger zf-C3HC4 PF00097.23 001114711.1_16126001_2 - 1.7e-07 30.9 12.5 1.7e-07 30.9 12.5 2.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001114711.1_16126001_2 - 9.5e-07 28.4 12.7 9.5e-07 28.4 12.7 3.1 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001114711.1_16126001_2 - 7.4e-06 25.6 9.7 7.4e-06 25.6 9.7 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001114711.1_16126001_2 - 5.5e-05 23.2 12.3 5.5e-05 23.2 12.3 4.2 4 0 0 4 4 4 1 Ring finger domain zf-RING_6 PF14835.4 001114711.1_16126001_2 - 0.0012 18.5 2.8 0.0044 16.7 2.8 1.9 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.4 001114711.1_16126001_2 - 0.0013 18.5 11.1 0.0013 18.5 11.1 3.6 3 1 1 4 4 3 1 zinc-RING finger domain zf-H2C2_2 PF13465.4 001114711.1_16126001_2 - 0.008 16.5 6.6 1.7 9.1 0.3 4.2 3 0 0 3 3 3 1 Zinc-finger double domain U-box PF04564.13 001114711.1_16126001_2 - 0.011 15.7 0.0 0.027 14.5 0.0 1.6 1 0 0 1 1 1 0 U-box domain zf-RING_10 PF16685.3 001114711.1_16126001_2 - 2 8.5 23.7 0.23 11.5 7.7 3.1 3 0 0 3 3 2 0 zinc RING finger of MSL2 zf-Nse PF11789.6 001114711.1_16126001_2 - 4.8 6.9 12.9 0.39 10.4 7.0 2.2 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-C2H2_4 PF13894.4 001114711.1_16126001_2 - 6.6 7.7 14.7 19 6.3 0.2 5.2 4 0 0 4 4 3 0 C2H2-type zinc finger # # Program: hmmscan # Version: 3.1b2 (February 2015) # Pipeline mode: SCAN # Query file: /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/smallRNE/simple/part9/wd/simple9.p.fa # Target file: /home/yduan/database/Pfam/Pfam-A.hmm # Option settings: hmmscan -o /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/smallRNE/simple/part9/hmmscan.outm --tblout /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/smallRNE/simple/part9/hmmscan.t.out /home/yduan/database/Pfam/Pfam-A.hmm /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/smallRNE/simple/part9/wd/simple9.p.fa # Current dir: /home/yduan/work_file/lncRNAdb/methods_assement # Date: Tue Jul 10 07:26:12 2018 # [ok]