XLOC_018033 (six6b)


Basic Information

Item Value
gene id XLOC_018033
gene name six6b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007131.7
NCBI id CM002904.2
chromosome length 55201332
location 20531002 ~ 20533865 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00035538
AGTCCAATAGAAACACAGAAGCGGGCAGCACGTCTTTTCCCTCCTCAAAAAAATATCTTCATTCTTGTGCTATAATCTCCTGCCCTCGAACTCTCGGTGTCTCCAACCGAGGCAGCGTCAGACCGACAGAGCGACATCTCCATTTCTCTGCATCGTCTAACATTCATCAGCTGACTCTGGAATTGCCTTTTTGTCTGGATTCGGCTGGGGAGCGAGAGAAAAGCCACAGAAAGCACGAAACCGTGCTAGAGGTAAACAGGACTGCGAGGGGGAAACAGAAGCCTTCATGTTTCAGTTGccaattttgaattttagtcCCCAGCAGGTAGCGGGGGTATGCGAGACTTTGGAAGAGAGCGGAGACATCGAGCGTCTCGGCCGATTCCTTTGGTCGCTCCCCGTCGCGCCCGCTGCCTGCGAGGTGCTGAACCGAAATGAGTCTGTGCTGCGGGCTCGAGCCATCGTAGCCTTCCACACTGGGAATTTCCGTGAGCTGTACCACATTCTTGAGAACCACAAGTTCACCAAAGAGTCCCACTCCAAACTGCAAGCACTTTGGCTGGAGTCACACTACCAGGAGGCAGAGAAGCTCCGAGGCCGCCCGCTAGGACCAGTGGACAAATACCGGGTACGGAAGAAGTTCCCCCTGCCTAAAACTATTTGGGATGGAGAACAAAAGACGCACTGCTTTAAAGAAAGGACCCGGCATTTACTTCGAGAATGGTATCTTCAGGATCCTTATCCGAACCCAAGTAAAAAAAGAGAGCTTGCACAAGCTACAGGACTCACTCCCACTCAAGTGGGGAATTGGTTTAAAAATCGAAGACAAAGGGACAGAGCCGCGGCCGCAAAAAACAGGTTACAACAGCAGGTGTTGTCGAACGGCTCGGTTCGGTCCTTAAGTGGAGAGGATGGTGCTGTAGACCGACTGGGGAATGCGTCAAGCCCTGAAGCGAGCCTGTCCAGCAAAGCCGCTGCGTCGGCGATCTCCATCACTTCAAGTGACAGCGAATGTGACATCTAACATCGCACCACGAACCGCCCCGCGGGCTATACGGGAAGACTATGAGAAAATTAACACATACGAAGGAAATCGAGACAGACAATCAGCAAGATAAACAAGCACATTAGTGCCTGCCTTAACGTATCAGAGGccgtgtttttgttttattttctttttttatttggagGCTGTTACACCAGCCGGAATCTTGGGATTCATGGAATGCTttatctttaaaatgtatttatgtttttgtgaGAGCAAAGTGGGGGAAACACGAACAAATgacatcagaaaaaaaagatgCTATCTGTATTAAAACTACTTTTGTAAACAAACTCGGTTGCCTCAAGCAAATAGGCTCCCCGACGgaacactttttcttttttattattgttttgaaaaGGACTTCATGGTGGTGAAACCGTTTACCTGCAGGTTTTCTAAGTGTTTACGCATTAAATTGCTCTTATAGAATCTGATTTTCAATTGTTTGGTCATTTCAAGTATGGTCATTTTCGGTGTTGACAGTCGACTTTTAGAGTATGTGCGCCGATAGTGAAGATATTAGTGAATGAAAGACTTACCGCTAATAAAATGTTGATCAAGTAA

Function

symbol description
six6b Enables double-stranded DNA binding activity. Involved in gene expression. Acts upstream of or within camera-type eye development and cell population proliferation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in brain; eye; and kidney. Human ortholog(s) of this gene implicated in optic disc anomalies with retinal and/or macular dystrophy. Orthologous to human SIX6 (SIX homeobox 6).

GO:

id name namespace
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0043010 camera-type eye development biological_process
GO:0007275 multicellular organism development biological_process
GO:0048856 anatomical structure development biological_process
GO:0045892 negative regulation of transcription, DNA-templated biological_process
GO:0001654 eye development biological_process
GO:0005634 nucleus cellular_component
GO:0005667 transcription regulator complex cellular_component
GO:0003677 DNA binding molecular_function
GO:0000976 transcription regulatory region sequence-specific DNA binding molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-050522-308 Enables double-stranded DNA binding activity. Involved in gene expression. Acts upstream of or within camera-type eye development and cell population proliferation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in brain; eye; and kidney. Human ortholog(s) of this gene implicated in optic disc anomalies with retinal and/or macular dystrophy. Orthologous to human SIX6 (SIX homeobox 6).

Ensembl:

ensembl_id ENSDARG00000031316

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00035538 True 1615 mRNA 0.47 2 20531002 20533865

Neighbor

gene id symbol gene type direction distance location
XLOC_018031 prkchb coding downstream 120875 20360337 ~ 20410127 (-)
XLOC_018030 hif1ab coding downstream 175425 20326611 ~ 20355577 (-)
XLOC_018029 snapc1a coding downstream 206210 20314574 ~ 20324792 (-)
XLOC_018028 si:ch211-212g7.6 coding downstream 218213 20275001 ~ 20312789 (-)
XLOC_018027 ppp2r5ea coding downstream 260811 20229586 ~ 20270191 (-)
XLOC_018034 ppm1ab coding upstream 67106 20600971 ~ 20611063 (-)
XLOC_018035 NA coding upstream 78027 20611892 ~ 20613628 (-)
XLOC_018036 NA coding upstream 147451 20681316 ~ 20690788 (-)
XLOC_018037 ckbb coding upstream 282882 20816747 ~ 20821789 (-)
XLOC_018038 xrcc3 coding upstream 362757 20896622 ~ 20901558 (-)
XLOC_017928 CU539064.1 misc downstream 10477301 10053405 ~ 10053701 (-)
XLOC_018023 NA non-coding downstream 741992 19735774 ~ 19789010 (-)
XLOC_018024 BX510657.2 non-coding downstream 757527 19773360 ~ 19773475 (-)
XLOC_018020 NA non-coding downstream 984414 19543143 ~ 19546588 (-)
XLOC_018021 dre-mir-206-1 non-coding downstream 986256 19544648 ~ 19544746 (-)
XLOC_018017 BX842692.1 non-coding downstream 1145925 19382427 ~ 19385077 (-)
XLOC_018040 BX004766.1 non-coding upstream 798149 21332014 ~ 21332128 (-)
XLOC_018043 BX296520.1 non-coding upstream 1465291 21999156 ~ 22015295 (-)
XLOC_018044 NA non-coding upstream 1509645 22043510 ~ 22070176 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000325_01378106_01381528 SIX6, SIX6B, SIX6A coding CI01000325 null 1377528 ~ 1381528 (-)