XLOC_022213 (gss)


Basic Information

Item Value
gene id XLOC_022213
gene name gss
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007134.7
NCBI id CM002907.2
chromosome length 46223584
location 14743087 ~ 14769523 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00043845
TTGCGTCATAACTATCCTGTTCGCTGATTGGTCGCTGTCAGCCATTGATACAAAcagcgccacacacacacacgcacacacacatacatttacatatCTATTAGCACGCCTGAAGCCACTTCATTTGTGTCAGTCTCATCACCTTCAGAGCAGGTGAATAGGcattaaatatattatacagaCTCACTGTAAACAACGACCTTCAGAGGCGCAGGAGAGACCAAACAGAGCCCGCGACTATCAGATTTAGTACTATGTCTGTCAAACTGGAGGACACCCTGAAAGATGAAAACCTGATCAAACGTTTAGAGGAGATAGCAAAAGACACGGCGCTGTTACATGGAGTGTTGATGCGGACCAAAGACACGCCAAACTCTCCTGAAGTGGTGAGTTATGCACCATTCACATTGTTTCCCACATCGGTGCCAGCAGCACTCTTTCATCAGGCACTGGCAGTGCAGACACAGTTTAACCGCTTGGTGGACCGGGTCAGCCAGAATCACAGTTTTTTAGAGGACACACTGGCCAGCACCATCAAAGTTGACGATTTTACAGCCAGACTTTTCAACATCTACAAACAAGTTCAGCAGGAGGGCCATGCTCAGAAAATAGTAGTGGGTCTGAATCGCTCAGACTACATGTTAGACCACAGTCCAGACGGTCGAACATCTCTGAAGCAGATTGAAATCAACACTATTGCTGCGAGTTTTGGTGGTCTTGCTTCACGAACACCAGATGTCCATCGGCACATTCTGAAGGTGGCAAACCTGCCAGATGAGTGCAGTCTTGTTCTCGACAACAACCCAGCAGCAGGTCTGGCCAAAGGTTTGGCCAAGGCCTGGGAGCTTTATGGATCCAAGAGGGCAGTGGTTTTGTTTCTGGTTGAGAATGTACAGAGGAATATTTATGACCATCGATATGTGGAGAACGAGCTGTGGAAAAGAAATATACCTGTAATAAGAAGACAATTTGAAGATGTTTTCAGGACTGGATCTCTGGATGAAAGCAAGAGGCTCTTCGTAGATGGCCATGAGGTAGCCATTGTCTACTTCCGAAATGGATACATGCCTCAAAACTACACCTCAGAGCAGAGCTGGGAGGTGCGTTTGATGATGGAGCGCTCCGTGGCAGTGAAGTGTCCAGATATCAGCACTCATCTCGCTGGGACTAAGAAAGTCCAGCAGGAATTAGCCCGGCCAGGTGTTCTGGAGTGCTTTTTCCCTGACGAACCTGAAACAGTTGCTCAGATCCGGGCGACTTTTGCTGGACTGTACACGCTGGACATGGGGGAAGAAGGTGATAATACCGTAGCGATGGCTTTGGCCAATCCAGATCAGTATGTGCTGAAGCCTCAGAGGGAGGGAGGAGGTAACAATATCTACGGCAGTGAGATCTGCGAAGTGTTGGAGAAGCTGAAGAACTCCAGTGAGAGAACAGCCTACATCCTGATGGACAAGATCCAGCCCGTCCCAGTCCAGAACATCCTGCTCAGACCCGGAGCTCCTCTGAAAGTCAGCTCCTGTCTCAGTGAACTGGGTGCATTCGGGGCGTACGTCAGGAAAGGCAGTGAATTGATGTTGAATGAGTGCGTTGGTCATCTTCTAAGGACCAAGAGCTCGGAGCATGCAGATGGCGGCGTTGCTGCAGGAGTAGCAGTGCTGGACAATCCACTTCTGGTCTGAACCACGGCGACACATGCTGTACTGGAGGAGAAACGCGTATGACTGACATCGGGGGATTCAGCCCAAATCATTTCTACCTGAGACCTGTTTGATCAAAGATTTAGAGTTGAATATCCTCTATTGATGAAGTAATCAATCAGTTATGACTGAACTACTTATTTCCTCAATAAGTTTTATACCTCATTCAAGGGTTGATCTGTTGATGTTTAGCCGttaatgttttataaaagcaaatttTGTTAATGCTTTCTTGGATGGTAACAGATGTTATTAACTCTCTGGTGATGTTCATTTAGTCATCACACTTGTGTAGTTCACTGTCAAAACAGACTGGAGACCATAGTCCTAAAGAGTCCGAAATTTACCCA
>TCONS_00043846
TGCAGATTTAGTACTATGTCTGTCAAACTGGAGGACACCCTGAAAGATGAAAACCTGATCAAACGTTTAGAGGAGATAGCAAAAGACACGGCGCTGTTACATGGAGTGTTGATGCGGACCAAAGACACGCCAAACTCTCCTGAAGTGGTGAGTTATGCACCATTCACATTGTTTCCCACATCGGTGCCAGCAGCACTCTTTCATCAGGCACTGGCAGTGCAGACACAGTTTAACCGCTTGGTGGACCGGGTCAGCCAGAATCACAGTTTTTTAGAGGACACACTGGCCAGCACCATCAAAGTTGACGATTTTACAGCCAGACTTTTCAACATCTACAAACAAGTTCAGCAGGAGGGCCATGCTCAGAAAATAGTAGTGGGTCTGAATCGCTCAGACTACATGTTAGACCACAGTCCAGACGGTCGAACATCTCTGAAGCAGATTGAAATCAACACTATTGCTGCGAGTTTTGGTGGTCTTGCTTCACGAACACCAGATGTCCATCGGCACATTCTGAAGGTGGCAAACCTGCCAGATGAGTGCAGTCTTGTTCTCGACAACAACCCAGCAGCAGGTCTGGCCAAAGGTTTGGCCAAGGCCTGGGAGCTTTATGGATCCAAGAGGGCAGTGGTTTTGTTTCTGGTTGAGAATGTACAGAGGAATATTTATGACCATCGATATGTGGAGAACGAGCTGTGGAAAAGAAATATACCTGTAATAAGAAGACAATTTGAAGATGTTTTCAGGACTGGATCTCTGGATGAAAGCAAGAGGCTCTTCGTAGATGGCCATGAGGTAGCCATTGTCTACTTCCGAAATGGATACATGCCTCAAAACTACACCTCAGAGCAGAGCTGGGAGGTGCGTTTGATGATGGAGCGCTCCGTGGCAGTGAAGTGTCCAGATATCAGCACTCATCTCGCTGGGACTAAGAAAGTCCAGCAGGAATTAGCCCGGCCAGGTGTTCTGGAGTGCTTTTTCCCTGACGAACCTGAAACAGTTGCTCAGATCCGGGCGACTTTTGCTGGACTGTACACGCTGGACATGGGGGAAGAAGGTGATAATACCGTAGCGATGGCTTTGGCCAATCCAGATCAGTATGTGCTGAAGCCTCAGAGGGAGGGAGGAGGTAACAATATCTACGGCAGTGAGATCTGCGAAGTGTTGGAGAAGCTGAAGAACTCCAGTGAGAGAACAGCCTACATCCTGATGGACAAGATCCAGCCCGTCCCAGTCCAGAACATCCTGCTCAGACCCGGAGCTCCTCTGAAAGTCAGCTCCTGTCTCAGTGAACTGGGTGCATTCGGGGCGTACGTCAGGAAAGGCAGTGAATTGATGTTGAATGAGTGCGTTGGTCATCTTCTAAGGACCAAGAGCTCGGAGCATGCAGATGGCGGCGTTGCTGCAGGAGTAGCAGTGCTGGACAATCCACTTCTGGTCTGA

Function

symbol description
gss Predicted to enable glutathione binding activity and glutathione synthase activity. Predicted to act upstream of or within glutathione biosynthetic process. Predicted to be active in cytosol. Is expressed in head kidney; lens; pronephric duct; and solid lens vesicle. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; and hemolytic anemia due to glutathione synthetase deficiency. Orthologous to human GSS (glutathione synthetase).

GO:

id name namespace
GO:0006750 glutathione biosynthetic process biological_process
GO:0005829 cytosol cellular_component
GO:0043295 glutathione binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0016874 ligase activity molecular_function
GO:0004363 glutathione synthase activity molecular_function
GO:0000287 magnesium ion binding molecular_function

KEGG:

id description
ko00270 Cysteine and methionine metabolism
ko00480 Glutathione metabolism
ko04216 Ferroptosis
ko04147 Exosome

ZFIN:

id description
ZDB-GENE-041010-208 Predicted to enable glutathione binding activity and glutathione synthase activity. Predicted to act upstream of or within glutathione biosynthetic process. Predicted to be active in cytosol. Is expressed in head kidney; lens; pronephric duct; and solid lens vesicle. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; and hemolytic anemia due to glutathione synthetase deficiency. Orthologous to human GSS (glutathione synthetase).

Ensembl:

ensembl_id ENSDARG00000037706

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00043845 False 2050 mRNA 0.47 13 14743087 14769523
TCONS_00043846 True 1443 mRNA 0.49 12 14743455 14766902

Neighbor

gene id symbol gene type direction distance location
XLOC_022212 NA coding downstream 4701 14735335 ~ 14738386 (-)
XLOC_022211 NA coding downstream 159548 14574498 ~ 14583539 (-)
XLOC_022210 CR388373.2 coding downstream 327874 14407888 ~ 14415213 (-)
XLOC_022209 nkain4 coding downstream 339148 14265122 ~ 14403939 (-)
XLOC_022208 ddx23 coding downstream 526581 14193547 ~ 14216506 (-)
XLOC_022214 sla2 coding upstream 38698 14808221 ~ 14990921 (-)
XLOC_022215 phf20b coding upstream 223277 14992800 ~ 15036789 (-)
XLOC_022216 si:ch211-218g4.2 coding upstream 277021 15046544 ~ 15090782 (-)
XLOC_022217 BX537335.1 coding upstream 338325 15107848 ~ 15107962 (-)
XLOC_022218 sulf2b coding upstream 434299 15203822 ~ 15330230 (-)
XLOC_022207 BX897727.1 non-coding downstream 753605 13989364 ~ 13989482 (-)
XLOC_022203 NA non-coding downstream 918895 13818507 ~ 13824192 (-)
XLOC_022219 NA non-coding upstream 662890 15432413 ~ 15563597 (-)
XLOC_022220 NA non-coding upstream 921008 15690531 ~ 15697049 (-)
XLOC_022221 NA non-coding upstream 927004 15696527 ~ 15764318 (-)
XLOC_022224 BX511184.1 non-coding upstream 1176631 15946154 ~ 15951976 (-)

Expression


Co-expression Network