Item | Value |
---|---|
gene id | XLOC_030065 |
gene name | tp53 |
gene type | coding |
species | zebrafish (Danio rerio) |
category of species | model fish |
Item | Value |
---|---|
chromosome id | NC_007116.7 |
NCBI id | CM002889.2 |
chromosome length | 72500376 |
location | 24086227 ~ 24097805 (+) |
genome version | GRCz11_2017_zebrafish_Genome |
symbol | description |
---|---|
tp53 | Enables DNA-binding transcription factor activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; intracellular signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in chromatin. Is expressed in several structures, including digestive system; head; musculature system; nervous system; and reproductive system. Used to study Li-Fraumeni syndrome; aggressive NK-cell leukemia; angiosarcoma; and cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53). |
id | name | namespace |
---|---|---|
GO:0048730 | epidermis morphogenesis | biological_process |
GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | biological_process |
GO:0006914 | autophagy | biological_process |
GO:0006915 | apoptotic process | biological_process |
GO:0006355 | regulation of transcription, DNA-templated | biological_process |
GO:0006357 | regulation of transcription by RNA polymerase II | biological_process |
GO:0000077 | DNA damage checkpoint | biological_process |
GO:0045786 | negative regulation of cell cycle | biological_process |
GO:0045787 | positive regulation of cell cycle | biological_process |
GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | biological_process |
GO:0006974 | cellular response to DNA damage stimulus | biological_process |
GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | biological_process |
GO:0048821 | erythrocyte development | biological_process |
GO:0007283 | spermatogenesis | biological_process |
GO:0043065 | positive regulation of apoptotic process | biological_process |
GO:0010165 | response to X-ray | biological_process |
GO:0051782 | negative regulation of cell division | biological_process |
GO:2000779 | regulation of double-strand break repair | biological_process |
GO:0061484 | hematopoietic stem cell homeostasis | biological_process |
GO:0016525 | negative regulation of angiogenesis | biological_process |
GO:0051262 | protein tetramerization | biological_process |
GO:0060729 | intestinal epithelial structure maintenance | biological_process |
GO:0007049 | cell cycle | biological_process |
GO:0060216 | definitive hemopoiesis | biological_process |
GO:0009411 | response to UV | biological_process |
GO:0031647 | regulation of protein stability | biological_process |
GO:0097193 | intrinsic apoptotic signaling pathway | biological_process |
GO:0090398 | cellular senescence | biological_process |
GO:0045893 | positive regulation of transcription, DNA-templated | biological_process |
GO:0071456 | cellular response to hypoxia | biological_process |
GO:0051597 | response to methylmercury | biological_process |
GO:0010526 | negative regulation of transposition, RNA-mediated | biological_process |
GO:0045944 | positive regulation of transcription by RNA polymerase II | biological_process |
GO:0043525 | positive regulation of neuron apoptotic process | biological_process |
GO:1902262 | apoptotic process involved in blood vessel morphogenesis | biological_process |
GO:0043249 | erythrocyte maturation | biological_process |
GO:0000785 | chromatin | cellular_component |
GO:0005634 | nucleus | cellular_component |
GO:0005737 | cytoplasm | cellular_component |
GO:0043565 | sequence-specific DNA binding | molecular_function |
GO:0005515 | protein binding | molecular_function |
GO:0046872 | metal ion binding | molecular_function |
GO:0003677 | DNA binding | molecular_function |
GO:0042802 | identical protein binding | molecular_function |
GO:0003700 | DNA-binding transcription factor activity | molecular_function |
GO:1990841 | promoter-specific chromatin binding | molecular_function |
id | description |
---|---|
ko04010 | MAPK signaling pathway |
ko04310 | Wnt signaling pathway |
ko04071 | Sphingolipid signaling pathway |
ko04151 | PI3K-Akt signaling pathway |
ko04137 | Mitophagy - animal |
ko04110 | Cell cycle |
ko04210 | Apoptosis |
ko04216 | Ferroptosis |
ko04115 | p53 signaling pathway |
ko04218 | Cellular senescence |
ko04919 | Thyroid hormone signaling pathway |
ko04722 | Neurotrophin signaling pathway |
ko04211 | Longevity regulating pathway |
ko05200 | Pathways in cancer |
ko05202 | Transcriptional misregulation in cancer |
ko05206 | MicroRNAs in cancer |
ko05205 | Proteoglycans in cancer |
ko05203 | Viral carcinogenesis |
ko05230 | Central carbon metabolism in cancer |
ko05210 | Colorectal cancer |
ko05212 | Pancreatic cancer |
ko05225 | Hepatocellular carcinoma |
ko05226 | Gastric cancer |
ko05214 | Glioma |
ko05216 | Thyroid cancer |
ko05220 | Chronic myeloid leukemia |
ko05217 | Basal cell carcinoma |
ko05218 | Melanoma |
ko05219 | Bladder cancer |
ko05215 | Prostate cancer |
ko05213 | Endometrial cancer |
ko05224 | Breast cancer |
ko05222 | Small cell lung cancer |
ko05223 | Non-small cell lung cancer |
ko05166 | Human T-cell leukemia virus 1 infection |
ko05161 | Hepatitis B |
ko05160 | Hepatitis C |
ko05162 | Measles |
ko05168 | Herpes simplex virus 1 infection |
ko05163 | Human cytomegalovirus infection |
ko05167 | Kaposi sarcoma-associated herpesvirus infection |
ko05169 | Epstein-Barr virus infection |
ko05165 | Human papillomavirus infection |
ko05131 | Shigellosis |
ko05012 | Parkinson disease |
ko05014 | Amyotrophic lateral sclerosis |
ko05016 | Huntington disease |
ko05417 | Lipid and atherosclerosis |
ko05418 | Fluid shear stress and atherosclerosis |
ko01524 | Platinum drug resistance |
ko01522 | Endocrine resistance |
ko03000 | Transcription factors |
ko03036 | Chromosome and associated proteins |
ko03400 | DNA repair and recombination proteins |
id | description |
---|---|
ZDB-GENE-990415-270 | Enables DNA-binding transcription factor activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; intracellular signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in chromatin. Is expressed in several structures, including digestive system; head; musculature system; nervous system; and reproductive system. Used to study Li-Fraumeni syndrome; aggressive NK-cell leukemia; angiosarcoma; and cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53). |
ensembl_id | ENSDARG00000035559 |
RNA id | representative | length | rna type | GC content | exon number | start site | end site |
---|---|---|---|---|---|---|---|
TCONS_00058800 | False | 2208 | mRNA | 0.43 | 11 | 24086227 | 24097797 |
TCONS_00058799 | False | 2211 | mRNA | 0.43 | 11 | 24086227 | 24097797 |
TCONS_00058801 | False | 2204 | mRNA | 0.43 | 11 | 24086227 | 24097805 |
TCONS_00058802 | False | 645 | lncRNA | 0.50 | 6 | 24086516 | 24091347 |
TCONS_00058803 | False | 748 | processed_transcript | 0.48 | 6 | 24086598 | 24091347 |
TCONS_00058804 | False | 1195 | mRNA | 0.49 | 9 | 24087035 | 24096882 |
TCONS_00058805 | False | 802 | processed_transcript | 0.49 | 6 | 24089324 | 24093867 |
TCONS_00058806 | True | 1956 | mRNA | 0.41 | 8 | 24089334 | 24097797 |
gene id | symbol | gene type | direction | distance | location |
---|---|---|---|---|---|
XLOC_030057 | NA | coding | upstream | 1998 | 23901787 ~ 24084229 (+) |
XLOC_030064 | gps2 | coding | upstream | 11689 | 24063046 ~ 24074538 (+) |
XLOC_030063 | gabarapa | coding | upstream | 24421 | 24059598 ~ 24061806 (+) |
XLOC_030062 | ctdnep1a | coding | upstream | 29431 | 24047292 ~ 24056796 (+) |
XLOC_030060 | AL928875.1 | coding | upstream | 63793 | 23994038 ~ 24022434 (+) |
XLOC_030066 | si:ch211-114c12.2 | coding | downstream | 31103 | 24128908 ~ 24135569 (+) |
XLOC_030067 | slc25a15b | coding | downstream | 58365 | 24156170 ~ 24163572 (+) |
XLOC_030068 | mpdu1a | coding | downstream | 81502 | 24179307 ~ 24185865 (+) |
XLOC_030069 | NA | coding | downstream | 102860 | 24200665 ~ 24228356 (+) |
XLOC_030070 | atp6v1aa | coding | downstream | 147877 | 24245682 ~ 24259992 (+) |
XLOC_030061 | NA | non-coding | upstream | 75328 | 24008862 ~ 24010899 (+) |
XLOC_030058 | CR391924.1 | non-coding | upstream | 175778 | 23910333 ~ 23910449 (+) |
XLOC_030056 | NA | non-coding | upstream | 201056 | 23873557 ~ 23885171 (+) |
XLOC_030055 | NA | non-coding | upstream | 260697 | 23822572 ~ 23825530 (+) |
XLOC_030071 | NA | non-coding | downstream | 163745 | 24261550 ~ 24278326 (+) |
XLOC_030074 | NA | non-coding | downstream | 242872 | 24340677 ~ 24450520 (+) |
XLOC_030075 | NA | non-coding | downstream | 371666 | 24469471 ~ 24472076 (+) |
XLOC_030078 | NA | non-coding | downstream | 718520 | 24816325 ~ 24835317 (+) |