XLOC_031910 (casp8)


Basic Information

Item Value
gene id XLOC_031910
gene name casp8
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007117.7
NCBI id CM002890.2
chromosome length 60270059
location 13045885 ~ 13058979 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00062482
TATTTGTTAAGAAACTGAAAGCAACTTGTTAATCGGAAGAAAACAGTAGCATTAGCATGCCAGTCCGGCTAGCCTGACTTTTATTCTTATACGCTACGAGGGTTCACTTCGATTTTATTTCACTTGGGTGGTGTAAACACCAAGTAGAATATGGATCCTCAGATCTTTCACGAGATTGATGAGAACCTGACAAGCGGTGATGTGGACCAGCTGAAGTTTCTGTGCTTAGATTTCATTCCCAAAAGGCGTTTGGAGTCAGTGACTGATGCTAAAGACCTGATTCTGCGACTGGATGAGCAAGGATTGCTTGAGGATGAGCTGCTCTTCCCTGAACTTCTGATCACAATTGGCCGCATTGACTTGCTCGAGATTCTGAAAAAATCTAAAGAGGAAGTGAAAAGAAATCTGCTACGATGTGATAATTCTCGTAAAGGTGTCTCAGCCTATAGAAAGATGCTATTGAAAATATCTGAGGACATGACAGAAGAAAACTTTCGCGCAGCAAAGTTTCTTTTGGATCTTCCAAGGGCAAAGCTGGGAAGATCTACTTCATTTCTAGATACTTTGATTGAGATGGAAAAACAACAGAGGCTTGGGCCAGACAATCTGGATGAACTTTACAGAATTTTAGAAAAATGTGACAAACAGCTGGCTGTTATGATCGAGAGGTTCAGGAATCAGAGTCACAGAGACCAGGAACAAGGAGGCAGACTTCCTCTAGAAGAAGTTTTTCTCAACAACCCTGTATCTGAAACAATGGAGAGAGAAAGGAGGAGAAACTCTTCGGCTGGCACAATTACTACAGacgcagaaactccattaaatCCAAACGAATATTACATACTGACCCAGCGGCCTCTTGGATACTGTTTAATCATCAACAACTACAACTTCTTGAAAAGTACTAACCTGCTCAAACGAACAGGCACTGATATGGACAAAGaTAGACTTGCCAAATTGTTTAGCAGAATGCATTTCCAGATTGAGGTACGGAGTGATCTGGAAGCCTGGGCTATAAAAGATGAGATAAAGCAGTTTGCAAATAAGAATCATGCTTCAATGGGTGCTTTTGTTTGCTGTATTCTCTCACACGGAGAGAAGGGCACAGTTTTGGGCACAGATGGTAAACCAGTTGAAATCCGAGAAGTCACTTTGCCTTTTGCCGGATGCAGAACACTAGCAAGCAAGCCCAAGCTTTTCTTTATTCAAGCCTGCCAAGGAGATGAGAACCAGGCTGGTGTTTGGACGTCGGATGGACGCGAGGATGCTCCTGAGGAAGACGAAAAATATGAGGAGGATGCAGGAATAATAGTGCTCCGCAAAATTCCAATCGAAGCTGATTTCCTGATCGGAATGGCCACAGTAGAGCACTACCTCTCCTACCGACACACTAAAGAGGGCTCTATCTTTATCCAGGAGCTCTGTAAAAAGATGGAGGAATTGTGTCCCAAgaAAGAGGACATGTTGTCCATTCTGACAAAGGTGAACTTTGAAGTGAGCAAAAGGATTTTGAAGGGCTACAAGCAGATGCCAGAACCACGCTACACGCTGACCAAGAAACTAGTGCTGCCCATAGACTGAAGTGTCTGGCTGAAGGATTGACTGGACACACGATGGACAATCTTCCGTTTTTCTGTTACTGGAACTCATTATAATTCTTCAGGGATGATCAGGCACTTCGCTATAGTTTTGTAATGATCttgctaggttttttttttttttggagtcttattatgaaataaaacattaaagtttACAGCACTCTGAGAATTTAGTTGAATGATCACTGCAATATAGAAGCAAAAACAATTTATATTTGataatatgcaaaaatattaGAAAAACTCATATTTTAGGTGAAGGACTTTGTACCATCTGATGTTTTGAATGCAGTTGTAATTGGACATGTCTGCCTTTAATGGAAATGGCTGAACTAGGAACACAAAGATTTTAAAGTTGTAAAAGAGAGCTGTTGTATGAAATTCCTGTATGTATTGAAAGCGATGAATAAACatcattgtcttttt
>TCONS_00062483
TAGAATATGGATCCTCAGATCTTTCACGAGATTGATGAGAACCTGACAAGCGGTGATGTGGACCAGCTGAAGTTTCTGTGCTTAGATTTCATTCCCAAAAGGCGTTTGGAGTCAGTGACTGATGCTAAAGACCTGATTCTGCGACTGGATGAGCAAGGATTGCTTGAGGATGAGCTGCTCTTCCCTGAACTTCTGATCACAATTGGCCGCATTGACTTGCTCGAGATTCTGAAAAAATCTAAAGAGGAAGTGAAAAGAAATCTGCTACGATGTGATAATTCTCGTAAAGGTGTCTCAGCCTATAGAAAGATGCTATTGAAAATATCTGAGGACATGACAGAAGAAAACTTTCGCGCAGCAAAGTTTCTTTTGGATCTTCCAAGGGCAAAGCTGGGAAGATCTACTTCATTTCTAGATACTTTGATTGAGATGGAAAAACAACAGAGGCTTGGGCCAGACAATCTGGATGAACTTTACAGAATTTTAGAAAAATGTGACAAACAGCTGGCTGTTATGATCGAGAGGTTCAGGAATCAGAGTCACAGAGACCAGGAACAAGGAGGCAGACTTCCTCTAGAAGAAGTTTTTCTCAACAACCCTGTATCTGAAACAATGGAGAGAGAAAGGAGGAGAAACTCTTCGGCTGGCACAATTACTACAGacgcagaaactccattaaatCCAAACGAATATTACATACTGACCCAGCGGCCTCTTGGATACTGTTTAATCATCAACAACTACAACTTCTTGAAAAGTACTAACCTGCTCAAACGAACAGGCACTGATATGGACAAAGaTAGACTTGCCAAATTGTTTAGCAGAATGCATTTCCAGATTGAGGTACGGAGTGATCTGGAAGCCTGGGCTATAAAAGATGAGATAAAGCAGTTTGCAAATAAGAATCATGCTTCAATGGGTGCTTTTGTTTGCTGTATTCTCTCACACGGAGAGAAGGGCACAGTTTTGGGCACAGATGGTAAACCAGTTGAAATCCGAGAAGTCACTTTGCCTTTTGCCGGATGCAGAACACTAGCAAGCAAGCCCAAGCTTTTCTTTATTCAAGCCTGCCAAGGAGATGAGAACCAGGCTGGTGTTTGGACGTCGGATGGACGCGAGGATGCTCCTGAGGAAGACGAAAAATATGAGGAGGATGCAGGAATAATAGTGCTCCGCAAAATTCCAATCGAAGCTGATTTCCTGATCGGAATGGCCACAGTAGAGCACTACCTCTCCTACCGACACACTAAAGAGGGCTCTATCTTTATCCAGGAGCTCTGTAAAAAGATGGAGGAATTGTGTCCCAAgaAAGAGGACATGTTGTCCATTCTGACAAAGGTGAACTTTGAAGTGAGCAAAAGGATTTTGAAGGGCTACAAGCAGATGCCAGAACCACGCTACACGCTGACCAAGAAACTAGTGCTGCCCATAGACTGAAGTGTCTGGCTGAAGGATTGACTGGACACACGATGGACAATCTTCCGTTTTTCTGTTACTGGAACTCATTATAATTCTTCAGGGATGATCAGGCACTTCGCTATAGTTTTGTAATGATCttgctaggttttttttttttttggagtcttattatgaaataaaacattaaagtttACAGCACTCTGAGAATTTAGTTGAATGATCACTGCAATATAGAAGCAAAAACAATTTATATTTGataatatgcaaaaatattaGAAAAACTCATATTTTAGGTGAAGGACTTTGTACCATCTGATGTTTTGAATGCAGTTGTAATTGGACATGTCTGCCTTTAATGGAAATGGCTGAACTAGGAACACAAAGATTTTAAAGTTGTAAAAGAGAGCTGTTGTATGAAATTCCTGTATGTATTGAAAGCGATGAATAAACatcattgtcttttttttttttttggcaaataatGTTGCATCACAAAACACAACGTTTGTTTTCCGTTCTAACCTAGACCATCTTATGAACACTTTTATTAgcatattttatgtaaatttgtGTAATTGTGTAAAACTTTTGTAATTGTAATTACTTACATTATTATACCAcctacatttatttttcttcggcttagtccctttatttatcaagggtcgccacagccgaatgtaccgccaactattcggcatatgttttatgcaatggatgtccttccagccacaacccaggactgagaaacacccataaactcatttacacacactcataatgcatgtctttggactgtgggagaaacctgagcacccaaagaaaacccacatgaacatgcaaactccacacataactGCCAAGCTGGGATTTAAACCAAAGacactcttgctgtgaggtgacagtgctaaccattgagccaccatgccatcccTGTAACACCTACAACTATAAAAAAGTAAGTCACACTTAAATCTCAGTTTCTATGATTTTAAAGGAACCACTGGGAAAGGATTTGAGCAAAAAAGCATTGTAGGTGCTTTTTTGTAggaggtggcgcagtaggtagtgctgtcacctcacagcaagaaggttgctggttgctggttcgagcctcagctgggtcagttggcatttctgtgtggagtttgcatgttctccctgcgtttgtgtgggtttgctccggtttccccctacagtccaaagacatgcggatcaggtgaattgggtagctaaattggcagtagtgtatgagtgtgtgtgaatgtgtgtgtggaagtttcccagagatgggctgcggctggaaggaatatatacacacacacacacatatatatatatatatatatatatatatacatatatacatacacacacacacacacacatatttatttatatatataatatatatatacatatatttatatatatatatatacacatatatatatatatatacacacacacatatatttatatacatatatatacatatacacacatatatatatatacacatatatatatacatatatatatacacacacacacacatatatatatatatacacatatatacatatatatatatacacacacatacacacacacacacatatatatatatatatacacacacacatatatacacacacacgtatatatatatatatatatatattcagcttaacgtgcaatttaaaggcttaactaggttaaactAGGCAAGTCAGGTTAATTAtgagtaaagtaaaagtaaacaaagttataaggaATACTGTGACAacttctttcctctgttaaacataacgagatatgtattttgaaaaagaattaaaaaaacaaggCAGTACCTAAAGCTGAATAGTTTTGCttttaagtgtatatatataaaacctttGAATAAGCTCTAGTGTGGCATTGATTGACTTGAtatagcaatatcacatgagtaacagtgcgatatggctgtatatcagcactggtgggaggcgtgcgttgccttagtgtcccaccagtgacgataaatagtcatatcgcactgctactagtgcgatattacatttatacaacagttcaatggcataatcgtgtatataaaaatgaaaatcaaacacgAGTCTAAACCCTTTTGTATGAATAAGTACTTTCTTCCGCCATGCATCCACATCTGctgctgacatcagaacagcagaaattgtTGCTACTTAACCAACGTCACTGTAGAACTAGTGTTTGAATCATTCTTTAGCCCAGGGGTGTcaagactcggtcctggagggccggtgtactgcaaagtttagtttcaaccccaatcggACACACCTGGGCTACACaaacaagctcttactaggcattctagaaacatccgtgcaggtgtgttaaagcaagttggagctaaattctgcaggacatcggccctccaggaccaagtttggacacttcTGCTCTAGCCTAATAAATACAGCACTTCAACatataaaagagagagattgacttagaatatcacttaccagtttaataatgatttgatcagctgtagttagaaacactGTTTTTCTCTTCTAAGGCCTTATTATGCGGTCTGtgtcgccatcttgtgaatgAACATCGTCAAACGTCTTTGCTTTAATGACAGGCTACTGGCCTTTTTCACTTAAAAACCTTAGATGtggattttattttttctttcagatGTTGATTGTTTAGTGGTT

Function

symbol description
casp8 Predicted to enable cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; and death effector domain binding activity. Acts upstream of or within induction by virus of host apoptotic process and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be active in cytoplasm. Is expressed in several structures, including axis; germ ring; heart; intestinal bulb; and nervous system. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and primary immunodeficiency disease. Orthologous to human CASP8 (caspase 8).

GO:

id name namespace
GO:0042981 regulation of apoptotic process biological_process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process biological_process
GO:0006915 apoptotic process biological_process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0019051 induction by virus of host apoptotic process biological_process
GO:0006508 proteolysis biological_process
GO:0005737 cytoplasm cellular_component
GO:0004197 cysteine-type endopeptidase activity molecular_function
GO:0008234 cysteine-type peptidase activity molecular_function
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process molecular_function
GO:0035877 death effector domain binding molecular_function
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway molecular_function
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis molecular_function

KEGG:

id description
ko04668 TNF signaling pathway
ko04210 Apoptosis
ko04214 Apoptosis - fly
ko04215 Apoptosis - multiple species
ko04217 Necroptosis
ko04115 p53 signaling pathway
ko04620 Toll-like receptor signaling pathway
ko04624 Toll and Imd signaling pathway
ko04621 NOD-like receptor signaling pathway
ko04622 RIG-I-like receptor signaling pathway
ko04625 C-type lectin receptor signaling pathway
ko04657 IL-17 signaling pathway
ko05200 Pathways in cancer
ko05203 Viral carcinogenesis
ko05170 Human immunodeficiency virus 1 infection
ko05161 Hepatitis B
ko05160 Hepatitis C
ko05164 Influenza A
ko05162 Measles
ko05168 Herpes simplex virus 1 infection
ko05163 Human cytomegalovirus infection
ko05167 Kaposi sarcoma-associated herpesvirus infection
ko05169 Epstein-Barr virus infection
ko05165 Human papillomavirus infection
ko05130 Pathogenic Escherichia coli infection
ko05132 Salmonella infection
ko05134 Legionellosis
ko05152 Tuberculosis
ko05145 Toxoplasmosis
ko05142 Chagas disease
ko05010 Alzheimer disease
ko05016 Huntington disease
ko05022 Pathways of neurodegeneration - multiple diseases
ko05417 Lipid and atherosclerosis
ko05416 Viral myocarditis
ko04932 Non-alcoholic fatty liver disease
ko01524 Platinum drug resistance
ko01002 Peptidases and inhibitors

ZFIN:

id description
ZDB-GENE-000713-1 Predicted to enable cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; and death effector domain binding activity. Acts upstream of or within induction by virus of host apoptotic process and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be active in cytoplasm. Is expressed in several structures, including axis; germ ring; heart; intestinal bulb; and nervous system. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and primary immunodeficiency disease. Orthologous to human CASP8 (caspase 8).

Ensembl:

ensembl_id ENSDARG00000058325

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00062482 False 2027 mRNA 0.41 10 13045885 13056726
TCONS_00062483 True 4136 mRNA 0.38 9 13046720 13058979

Neighbor

gene id symbol gene type direction distance location
XLOC_031909 catip coding upstream 344 13039951 ~ 13045541 (+)
XLOC_031908 pnkd coding upstream 8070 13024448 ~ 13037815 (+)
XLOC_031907 si:ch73-71c20.5 coding upstream 52383 12986853 ~ 12993502 (+)
XLOC_031906 mcm6 coding upstream 60495 12968101 ~ 12985390 (+)
XLOC_031905 cxcr4a coding upstream 122158 12922002 ~ 12923727 (+)
XLOC_031911 l3hypdh coding downstream 24167 13083146 ~ 13091856 (+)
XLOC_031912 dytn coding downstream 37933 13096912 ~ 13133917 (+)
XLOC_031913 CT009620.1 coding downstream 142379 13201358 ~ 13204969 (+)
XLOC_031914 ndufs1 coding downstream 147537 13206516 ~ 13254851 (+)
XLOC_031915 NA coding downstream 201103 13260082 ~ 13267143 (+)
XLOC_031897 AL929243.2 non-coding upstream 1271153 11774617 ~ 11774732 (+)
XLOC_031889 BX548046.3 non-coding upstream 2027353 11018416 ~ 11018532 (+)
XLOC_031888 NA non-coding upstream 2037455 10988645 ~ 11008430 (+)
XLOC_031887 NA non-coding upstream 2114795 10930890 ~ 10931090 (+)
XLOC_031885 NA non-coding upstream 2155661 10889061 ~ 10890224 (+)
XLOC_031917 NA non-coding downstream 285696 13344675 ~ 13348236 (+)
XLOC_031925 dre-mir-153b non-coding downstream 921966 13980945 ~ 13981092 (+)
XLOC_031933 NA non-coding downstream 2246786 15305765 ~ 15308585 (+)
XLOC_031935 CR956630.1 non-coding downstream 2485076 15544055 ~ 15544170 (+)

Expression


Co-expression Network