XLOC_032183 (oca2)


Basic Information

Item Value
gene id XLOC_032183
gene name oca2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007117.7
NCBI id CM002890.2
chromosome length 60270059
location 37894220 ~ 38054851 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00062881
aaccgactcccatacaaaggagttgctggttcgatcccaCATAGAAAAAAGTGCAGTTTTGAAAATACCTGTGTTATCACGCTGGGATTTAATAATTCTCTGCTTGTTCACAGGCACAGCTTCAACATGGTAAACCTCCTCAATGGCAAATCCAACCAAGCAAACCACACAGAGCGGACACCACTTCTCAAGTTCTCCCAAAATGATAGTATCACCTACATGACTCTGCATGAGCCCAGTCTGGGGTCTGGAGAGGAATCGTGGGAGGCGAGCTCTGCTGAACTGGAGAGAAGGTGCAGGCTGGGCAGTGAGGTCACCAGTCTCTCACACATTACATCCCCGGAGAAGAGTGAAAATTACTTCAAACTCTCTTTTCCCATCAGttcagttcagtgtggtttaaatttccaaataccaaatactgaagaACTCATCACCATCTTCGTTATTGTCGTTCTGTGTTCACTGTTTTTCAGCATGTATCCCGACCGGGAGAGCCCCTGGAGGATGCTGGCGGTCTCATCCACCGAGAGCTTCTCCATGAATCTTACTGATTTTCGTGACAACTCCTTGCTGAAGTTGCAAGTCGGTGGGCCATTTTTGGGAGGGATGGAGGCTGTGCAAGAGTCCCAGGAGTATATTCTCATCCAGGTGGAGCAGACTGAGGAGGCCGGGCCTCGCCGGAGAAGAACTCAGCAGGTGCTGTATAATTGGACCATACCACTGCACTCCCAGCGAAGTGACCAAATTCTGAGAACAAGGACATTTGAAATGGTTAGCAGCGCTCCTATTCAGATCAGCGTTCAGGCCTTTCTGCTGGACAATCAGGTAGTTCCTCTGTCCATGACTAACCAGTCGCTGTACGTGACGGTGGAAACACAGGTGCTCATCGCTGGTCTGATCCTGGCAGGAGTCTACGTGCTTATTATCTTTGAGATTGTTCACCGCACTCTGGCTGCAATGTTAGGATCCCTGTCTGCTCTGGCAGCTCTGGCTTTCATTGGAGATAGGCCGAGTCTTATGACTGTTGTGGAATGGATTGACTATGAGACGCTTGCCTTGCTATTTGGAATGATGATACTGGTGGCAATATTCTCGGAGACTGGTTTCTTTGATTACTGTGCGGTAAAGGCCTATCAGTTATCACGAGGAAGAGTTTGGCCCATGATTATCATTCTCTGCTTAATTGCTGCCATTCTGTCTGCCTTCCTTGATAATGTGACAACTATGATGCTCTTCACCCCTGTGACTATAAGGCTTTGTGAGGTGCTTAATCTGGACCCCAGGCAGGTCCTGATTGCAGAAGTAATCTTCACCAACATCGGAGGAGCTGCCACTGCTGTCGGAGATCCTCCCAATGTCATCATCGTATCCAACCAGGATCTCCGTAAAAAAGGGATTGACTTTGCGGCCTTTACGGGTTACATGTTCCTGGGAATCTGCCTGGTGCTGCTGACCTCGTTTCCCTTTTTGAGGTTGCTGTTCTGGAATAAGAAACTTTACAACAAGGAATCAAGTGAAATCGTGGAGCTGAAGCATGAGATTCTGGTGTGGAGGCAGACAGCCCATCGCATTAACCCTGCCAGCCGAGAGGAGACCGCCGTCAAGTGTCTTCTCATGCAGAAGGTGCTCAATCTGGAAAGCCTCCTGCGCAAGAAGCTCAAGACCTTCCAGAGGCAGATTTCGCAGGAAGACAAAAACTGGGAGCACAATATTCAAGAGCTGCAGAAAAAGcACAGAATAACAGACAAAGTCCTCTTGGTGAAGTGCTTGACTGTCCTCGGTGTGGTCATTTTCATGTTCTTCCTGAACTCCTTTGTTCCTGCCATACATCTGGATTTGGGTTGGATCGCTATCTTGGGGGCTCTGTGGTTACTGGTGCTTGCTGACATTCAGGACTTTGAGATCATTCTTCATAGAGTAGAATGGGCCACGCTGTTGTTCTTCGCTGCTCTGTTTGTGCTCATGGAGGCTCTCGCTCAGCTGCAGCTCATCGACTACATTGGGGAGCAGACTGCAGTGTTGATAAAAGCAGTGCCAGAGGATGAACGGTTGGCCATCGCCATCATTTTGGTATTGTGGGTTTCAGCGCTGGCGTCCTCTCTAATAGACAACATTCCCTTCACTGCCACTATGATTCCAGTACTCATAAATCTCAGTCAAGATGCCGATGTCAACTTGCCAATCAAACCTCTCATATTTGCATTGGCTATGGGAGCATGCCTTGGAGGAAATGGTACACTGATTGGAGCATCTGCAAACGTGGTGTGTGCTGGGATTGCTGAACAGCACGGCTATGGATTTTCCTTCATGGAGTTCTTCAGGTTGGGCTTCCCTATGATGCTTATGACCTGCACAATAGGCATGTGTTACCTGCTCGCAACCCACATCGGACTTCACTGGAACACATAA
>TCONS_00062882
ctatgccccaccctctcttcattttttcAGTTgcgattacatcaaacattgaattCAAAATGCACATTTCGAAGCACTTCACAATTGTCACTGGTGGCGATGCCCCCatcatatatttTCACGCTGGGATTTAATAATTCTCTGCTTGTTCACAGGCACAGCTTCAACATGGTAAACCTCCTCAATGGCAAATCCAACCAAGCAAACCACACAGAGCGGACACCACTTCTCAAGTTCTCCCAAAATGATAGTATCACCTACATGACTCTGCATGAGCCCAGTCTGGGGTCTGGAGAGGAATCGTGGGAGGCGAGCTCTGCTGAACTGGAGAGAAGGTGCAGGCTGGGCAGTGAGGTCACCAGTCTCTCACACATTACATCCCCGGAGAAGAGTGAAAATTACTTCAAACTCTCTTTTCCCATCAGATATTGCCTAGGGATGACAAGACTCATCACCATCTTCGTTATTGTCGTTCTGTGTTCACTGTTTTTCAGCATGTATCCCGACCGGGAGAGCCCCTGGAGGATGCTGGCGGTCTCATCCACCGAGAGCTTCTCCATGAATCTTACTGATTTTCGTGACAACTCCTTGCTGAAGTTGCAAGTCGGTGGGCCATTTTTGGGAGGGATGGAGGCTGTGCAAGAGTCCCAGGAGTATATTCTCATCCAGGTGGAGCAGACTGAGGAGGCCGGGCCTCGCCGGAGAAGAACTCAGCAGGTGCTGTATAATTGGACCATACCACTGCACTCCCAGCGAAGTGACCAAATTCTGAGAACAAGGACATTTGAAATGGTTAGCAGCGCTCCTATTCAGATCAGCGTTCAGGCCTTTCTGCTGGACAATCAGGTAGTTCCTCTGTCCATGACTAACCAGTCGCTGTACGTGACGGTGGAAACACAGGTGCTCATCGCTGGTCTGATCCTGGCAGGAGTCTACGTGCTTATTATCTTTGAGATTGTTCACCGCACTCTGGCTGCAATGTTAGGATCCCTGTCTGCTCTGGCAGCTCTGGCTTTCATTGGAGATAGGCCGAGTCTTATGACTGTTGTGGAATGGATTGACTATGAGACGCTTGCCTTGCTATTTGGAATGATGATACTGGTGGCAATATTCTCGGAGACTGGTTTCTTTGATTACTGTGCGGTAAAGGCCTATCAGTTATCACGAGGAAGAGTTTGGCCCATGATTATCATTCTCTGCTTAATTGCTGCCATTCTGTCTGCCTTCCTTGATAATGTGACAACTATGATGCTCTTCACCCCTGTGACTATAAGGCTTTGTGAGGTGCTTAATCTGGACCCCAGGCAGGTCCTGATTGCAGAAGTAATCTTCACCAACATCGGAGGAGCTGCCACTGCTGTCGGAGATCCTCCCAATGTCATCATCGTATCCAACCAGGATCTCCGTAAAAAAGGGATTGACTTTGCGGCCTTTACGGGTTACATGTTCCTGGGAATCTGCCTGGTGCTGCTGACCTCGTTTCCCTTTTTGAGGTTGCTGTTCTGGAATAAGAAACTTTACAACAAGGAATCAAGTGAAATCGTGGAGCTGAAGCATGAGATTCTGGTGTGGAGGCAGACAGCCCATCGCATTAACCCTGCCAGCCGAGAGGAGACCGCCGTCAAGTGTCTTCTCATGCAGAAGGTGCTCAATCTGGAAAGCCTCCTGCGCAAGAAGCTCAAGACCTTCCAGAGGCAGATTTCGCAGGAAGACAAAAACTGGGAGCACAATATTCAAGAGCTGCAGAAAAAGcACAGAATAACAGACAAAGTCCTCTTGGTGAAGTGCTTGACTGTCCTCGGTGTGGTCATTTTCATGTTCTTCCTGAACTCCTTTGTTCCTGCCATACATCTGGATTTGGGTTGGATCGCTATCTTGGGGGCTCTGTGGTTACTGGTGCTTGCTGACATTCAGGACTTTGAGATCATTCTTCATAGAGTAGAATGGGCCACGCTGTTGTTCTTCGCTGCTCTGTTTGTGCTCATGGAGGCTCTCGCTCAGCTGCAGCTCATCGACTACATTGGGGAGCAGACTGCAGTGTTGATAAAAGCAGTGCCAGAGGATGAACGGTTGGCCATCGCCATCATTTTGGTATTGTGGGTTTCAGCGCTGGCGTCCTCTCTAATAGACAACATTCCCTTCACTGCCACTATGATTCCAGTACTCATAAATCTCAGTCAAGATGCCGATGTCAACTTGCCAATCAAACCTCTCATATTTGCATTGGCTATGGGAGCATGCCTTGGAGGAAATGGTACACTGATTGGAGCATCTGCAAACGTGGTGTGTGCTGGGATTGCTGAACAGCACGGCTATGGATTTTCCTTCATGGAGTTCTTCAGGTTGGGCTTCCCTATGATGCTTATGACCTGCACAATAGGCATGTGTTACCTGCTCGCAACCCACATCGGACTTCACTGGAACACATAA

Function

symbol description
oca2 Acts upstream of or within iridophore differentiation; melanin biosynthetic process; and melanocyte differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in actinic keratosis; oculocutaneous albinism type II; pigmentation disease; skin cancer (multiple); and squamous cell carcinoma. Orthologous to human OCA2 (OCA2 melanosomal transmembrane protein).

GO:

id name namespace
GO:0042438 melanin biosynthetic process biological_process
GO:0050935 iridophore differentiation biological_process
GO:0055085 transmembrane transport biological_process
GO:0043473 pigmentation biological_process
GO:0030318 melanocyte differentiation biological_process
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component

KEGG:

id description
ko01009 Protein phosphatases and associated proteins
ko02000 Transporters

ZFIN:

id description
ZDB-GENE-070718-4 Acts upstream of or within iridophore differentiation; melanin biosynthetic process; and melanocyte differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in actinic keratosis; oculocutaneous albinism type II; pigmentation disease; skin cancer (multiple); and squamous cell carcinoma. Orthologous to human OCA2 (OCA2 melanosomal transmembrane protein).

Ensembl:

ensembl_id ENSDARG00000061303

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00062881 False 2412 mRNA 0.48 25 37894220 38054851
TCONS_00062882 True 2430 mRNA 0.49 23 37894914 38054851

Neighbor

gene id symbol gene type direction distance location
XLOC_032182 herc2 coding upstream 46345 37752781 ~ 37847875 (+)
XLOC_032181 cyfip1 coding upstream 163313 37655078 ~ 37730907 (+)
XLOC_032180 tubgcp5 coding upstream 241703 37623693 ~ 37652517 (+)
XLOC_032179 slc9a7 coding upstream 293572 37529383 ~ 37600648 (+)
XLOC_032178 NA coding upstream 418119 37470116 ~ 37476101 (+)
XLOC_032184 AL935047.1 coding downstream 32644 38087495 ~ 38087611 (+)
XLOC_032185 NA coding downstream 303830 38358681 ~ 38360443 (+)
XLOC_032186 CR405707.1 coding downstream 322240 38377091 ~ 38377211 (+)
XLOC_032187 gabrb3 coding downstream 327106 38381957 ~ 38513578 (+)
XLOC_032188 CR628341.3 coding downstream 463368 38518219 ~ 38590172 (+)
XLOC_032176 BX324166.1 non-coding upstream 559257 37334559 ~ 37334963 (+)
XLOC_032175 NA non-coding upstream 578311 37314337 ~ 37315909 (+)
XLOC_032172 NA non-coding upstream 643856 37184193 ~ 37250364 (+)
XLOC_032171 BX950870.1 non-coding upstream 903536 36990570 ~ 36990684 (+)
XLOC_032194 NA non-coding downstream 898630 38953481 ~ 38955126 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000340_08259928_08321896 OCA2 coding CI01000340 null 8259928 ~ 8321896 (+)
bowfin (Amia calva) AMCG00014309 oca2,LOC107716962 coding CM030128.1 CM030128.1 8478982 ~ 8507687 (+)