mfn2 (mfn2)


Basic Information

Item Value
gene id mfn2
gene name mfn2
gene type coding
species eurasian perch (Perca fluviatilis)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_053116.1
NCBI id CM020913.1
chromosome length 44101041
location 4030523 ~ 4059713 (+)
genome version GENO_Pfluv_1.0_2020_eurasian_perch_Genome

Sequence

>XM_039800188.1
ACCGCGATACTTGTGCTTTAAAATGTCGATCCAGCCCAACATGTCAGGGAAAGACCAAAGTGGCTGGTAATGTGCTGAAACAAAGTGGTGTTCTGGGAACAGAAAACAACCTAGTTTGGAATATATCTATCTATTGGGAGTCAAACCTACGTTGCTCGCTGACAGTGCTCCAAAACAGCTTGTAGCTTCGTCAACCCTGGGCTCGCTTGAAACATTTAGCGACGCCCCCTAGCATCCACTGCGACTAGTCGCGCAGTAACTATAGCGATTAGCTTGTAGCTTTCAAACCCCAGGGGCCAGGATGCGAGAGGATTCTTTGTGAGGAACGACCCCATCCACGTGCCATGTCTTTGGTTTTCCCTCGACCCAACACCAACGCAGTACACGGCAAGAAGGATAAGAGACTGATGGCGGAAGTGAATGCATCACCACTCAAGCATTTTGTCACGGCAAAGAAGAAGATCAACGGGATCTTTGAGCAGTTGGGGGCCTACATCAAGGAGAGCGCTTCCTTTCTGGATGATACTTACAAAAATGAAGAGCTGGACCCAGTCGCCACAGAGGAGCAGGTCCAGGAGGTCCAGGGCTACCTGGCCAAGGTGGCAGGGATTGGAGAAGTACTTGCACGCAGGCATATGAAGGTGGTCTTCTTTGGGAGGACGAGTAATGGGAAGAGCTCGGTGATCAATGCCATGCTCTGTGACAAGGTGCTGCCGTCTGGAATAGGACACACCACCAACTGCTTCCTGAGGGTGGAGGGCACCGATGGCAATGAGGCCTTCCTGCTCACGGAAGGCTccgaggagaggaagagcataaaGACGGTGAACCAGCTGGCCCACGCGCTCCACCAGGATGAGGATCTGGACGCCGGCAGCTTGGTCTGCGTCATGTGGCCCAAAGCCAAGTGTGCTCTGCTCAGGGATGATCTGGTGTTGGTGGACAGCCCGGGGATAGATGTTACCACAGAACTGGACAGCTGGATTGACAAGTTCTGCCTGGATGCTGATGTTTTTGTTCTGGTGGCAAACTCTGAGTCCACACTGATGCAGACGGAGAAGTCTTTCTTTCACAAGGTCAATGAGCGGCTCTCTAGTCCCAACATTTTCATCCTCAACAACCGCTGGGACGCCTCAGCCTCCGAACCTGAATACATGGAGGAGGTCCGCAGGCAGCACATGGACCGCTGCACCAACTTCCTGGTGGATGAGCTGGGTTTGGTGGACCGAGCCCAGGCCAGTGACCGCATCTTCTTCGTCTCTGCCAAGGAAGTCCTTCAGGCTCGTGTGCAGAAGGCTCAAGGAATGCCTGAAGCAGGTGGAGCTCTTGCAGAGGGATTTCAAGCCAGAATGTTTGAGTTTCAGAACTTTGAGAGGCGGTTCGAGGAGTGTATCTCGCAGTCAGCGGTGAAGACCAAATTTGAGCAGCACACCGTGAGGGCCAAACAGATCTCTGAAGCCCTGCGCCGCATCATGGATTCAGTACACATTGCTGCACAAGAGCAGAGGGTCTACTGCCTTGAGACAAAAGACGACCGCCAGGACCGATTGGAATTCATAGACAAGCAGTTGGACTTGTTGACCATGGACTGTAAGGCCAAGATCAAGAAGATCACTGAGGAGGTGGAGAGACAGGTGTCTAATGCCATGTCAGAGGAGATCAGGAAGCTCCATGTGCTGGTGGATGACTTCCACATGGACTTCCACCCATCACCAGTGGTACTCAAGGTCTACAAGAATGAGCTCCACCGGCACATAGAGGAGGGTCTGGGCAAGAACATGTCCGAGAGGTGCTCCACCTCCATCACCAGTTCCCTGCAGGCCACGCACACAGACATGATCGagggtCTGAAGCCTCTGCTTCCCAACCTGGTCAGAGAGCAGGTAGACAAGCTGGTTCCCCGTCAGTGCTTCAGCCTCAGTTATGACCTGGCCTGTGACAAGCTGTGCAGTGACTTTCAGGAGGACATCAgcttccacttctctctgggCTGGACCATGCTGGTCAACCGCTTCCTGGGCCCTAAGAACACCCGGCGGGCCCTCATTGGCTACAACGACCAGGTGCCCAGGCCCCTGGCTCTGACTCCTGTCAGCAGCAGCATGCCTCCGTTCCCCCAGAGCTCCGTCACCCAGGAGGAGCTCATGGTCTCCATGGTGACTGGGCTGGCTTCCCTTACATCTCGTACCTCCATGGGTGTCCTTGTGGTTGGCGGCGTgATCTGGAAGGCAGTGGGCTGGCGTCTGATCGCCCTGTCAGTGGGTCTGTACGGACTCCTCTACATCTACGAGCGGCTCACCTGGACCACCAAGGCCAAGGAGAGAGCCTTCAAGAGACAGTTTGTGGACTACGCCAGCGAGAAGCTGCAGCTCATCGTCAGCTACACTGGATCCAACTGCAGCCACCAAGTCCAGCAGGAGTTGGCAGGTGTGTTTGCTCAGCTCTGCCAGCAGGTAGACGTCACCCGTCAGAACCTGGAAGACGAGATCACCGACATGAACAGCAAGATGGAGCTGCTGGATAGCCTTCAGAGTAAGGCCAAGCTGCTGCGgaACAAGGCGGGCTGGCTGGACAGTGAGCTCAACATGTTCACCCAGCAGTACCTCCACCACAGCAAGTAGAGCACTCAGAGGATTGGCTGAGAGACTGAGAAATACCAGAGGAACATCTGGAACACCTGCcgaacccctcccccccccaccccctgtaGATGACACACTTCTGTATTTAGAAGTTAATGAGAGGAAATACTCCAAAATGTTGTGAAGAGAAGACGAGAAAAGAGAAGGGATGGTTTGATGTGAGAGGAAGAGTTACCTGGTGGCTGAGACGGCCATACGTGGACCTGAGCTCCGGTTGGGTGTCCTGTGCTCAGCTGGTGACCTgtcacacaaaactaaaaagTGAGTCAGCTATTAGATAGAAGCCacaacataaaatattaaatggaagaaaaaaaaaaaaaaaaaaaggtttaaccAACCCCCTACCATGCCCTCAGTGTATTTCCTGATGCTTGTTCTTATCATTGAGCACTTTGAAGTCCAGTCGTGGTGATATGTCACCAGATGTCTGACGCGTCTCAGCACTGGACATCGTTGGCACTGTCACAAACTCCACACTGGCCTTTTTACATCCGATTCTAGTTAACTCTCGCCACATTGAACGTGTGTAGGTTTTGATTTTGTAAATACATTAGGAACAGCGGACAACGCCATGCTGACGTAAAAAAGGCAGTCTACATGAGGGAATAGAAGGAAGGGGCTTCTGTTAGAAGGATACTGCAACATCAGTTATAACtccagctgttgttgttgttgttgtttttgggaAAATGTAGCCCTGTTCAGAGGACAAAGCTGTTGGAAATGATCTTGGTTGTGGTTGGAGGTTGCCACTGAGAAACAACTGTCGTGTTGACCTGCGCTCCTTTTTTGTCAATCAAAGTGACGAGAAGGAGGACCACTCCTCCCTCTCAAAGCTTGGTCCTGTGAGCACTGAGTAGAAGTGTCAACAGCTGTTGATGGTCTCAGAGTGGAGATGGCTGATTATTTAAACTACATATAAACCCCTTGGCCCTATATGTAAAATAGCCTGACGTCTACATTCGTATGTAGTGCATTTGCTTTACTGTTCCTTTAGAGGGTAAACCTACATCTTTGTTTTACAAGGATACTGAAGTTGCTTGGGCTGTGAAGTCATTGAATACATTTTAGAATTTTAAACAACAAAGgagaaaaatgtaaaattcctTTATCCTAACTTTTAAGGGTAAAGagaaaatagtgcatttgttgggggaCTGTGTGGATCATGGGACAGTGTGAACAATGGAACTACATGGCACAGAGGAATGAGATGTATCGGGCGTTGGGTATACACACAATACTTAATAGGATACATTCATTTGTCGAAGAAATTTGTTTCATTCACTTTGTATTCCACAACTTTGAAGACTAGAGCCTATGTCAGATGTTATCAGCACGTGTCATCTATTAAAGCCGGAATCTTTGCCCAACCCAGTTTGTTTTGGCCGTCGTTGGGCAAAGattgcatttgtttttcaaGTGTTCTGAGAGAAAACCAGGACTTGTGTGCCTCCTCTTTGGCTCTCTctcaggctttagaaaatctagtcTGTGatgggagactttggccaatcgccggtcatttcagagagagagctttccTATTTGCAGGTCCCTTCACAACTCTGGGCCCGTCGCATGATGCCCTTAGAgcccaaaaagactttttcCCCATCGATATACATGGCGAGAGAAAGGTCGGTTAAGCTgcggatagttttttttttttttttaacgtcgCAACCCTTGTGAATTGACCCGTTTtactatcagaatttgatccgataacatttggaaagtgtAGAAGAGCAGCATGATTAAGTCATCGTATACCCACTCAAATTAGGCGGGGTGCTTCACGCAACTCTCAGAGGAATGAACGGAGCTCCGCCTCCAACGCTGTATCCAATTCTTATTATACTAATACTATTATCTATGCCCACAGCTTTAAATAGCAGATGTCAGCACATAAATGCCAAAGATATGTCTGAGGACAATTAAGGAGCTGTCTCCATTAGactttgtccaccagagagcgGCGGAGTTTATATTTACTCTATAAAATGTCCCACTCAGCAGATATACTCGTCACTGGTCATTATTTAATAACCACAATGAAAGAATTCTCATCACAAATGTTAATGTTCCTGTAATGTGTTTATGTGAAACGATAGCTCTGACTTGGCGGAttatgatatgatgatgatgatgatgatgatgatgatgatgatgatgatgatgatgagcctATAAAATCCATTGGTCGGTCTCCGACACCTTTACATTTCATGTCCTCAACCACAAAATGTTTGGATTTTCAAAACGTCCGTGTGGAGTTCAGAGGGGATTTGGTATGTCAGGTGAacttaaaaacaaactgcgtGGGTGTGCAACTTCATTTTCAGCTTTCTCTCATTAAACTCGGAATCCTGACTTTTCTCACCATTCACAAATGATCTCCGGCGTCGGAACGACTTTCGTGCGGCCCTAATTGTCTTCCGTACATATTTAATAAAACCGACCCAACTGTTAACATGATTCTGATGTGAGATGGTAGCACTGGCAGTCAGTCTCCTGTGTATCACCACTACTCAGTACTTTTATTTGGGCAGAGGAAGGTTTTTGTCTTGCACTGAATGCATATGTGGCCAGGTCTCTGCCAGCGTCACCGAAGGTTCCACTTAAAAACAAAGAGGTAGGAACTACATATGATGGCGTATGTAAGAGGGGCCAAATCTAGCATCAGCTCccctttttttaatgaaattgtaCTCTTGGTTTctaaaatatgtatataatgtaatttattaatttgcCTTTCAATTGGAACCAATGGGGAAATTGCTGAAGGAGACAAAACCACACCAGACTGGATGTGCCTGAATTAGTCCAGTATGTAAAAGTTGTGGTCGATTGGGCCATGCTGTCAATGAAAGCCATACACTGCGTGTTGCCAATTGAGCAGGAAGGCTGCCGTGAAGATATGCACTTTATcagtttgctgcttttttttgggatttttttcttttctttgatgAAGTTAGTTTTTCCCCAGAATCCTCTCTACACAACACAAAGTTAGTGGTTTGGCTTCAGGAAGGTGAAAGTACCTAGCATGCAGTGTGGATGTTGTAGTTTGTTCTAATGttcaaatatgtatgtatgtatgtatgtgaaaaataaagGTGACACCATGCAAAAACAGC

Function

symbol description
mfn2 Predicted to enable GTPase activity. Acts upstream of or within several processes, including axonal transport of mitochondrion; axonogenesis; and neuromuscular junction development. Predicted to be located in mitochondrial outer membrane. Predicted to be integral component of membrane. Predicted to be intrinsic component of mitochondrial outer membrane. Is expressed in several structures, including heart; muscle; nervous system; otic vesicle; and ventral mesenchyme. Used to study Charcot-Marie-Tooth disease type 2. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; and Charcot-Marie-Tooth disease type 6. Orthologous to human MFN2 (mitofusin 2).

NR:

description
unnamed protein product

GO:

id name namespace
GO:0007528 neuromuscular junction development biological_process
GO:0006184 obsolete GTP catabolic process biological_process
GO:0048662 negative regulation of smooth muscle cell proliferation biological_process
GO:0007409 axonogenesis biological_process
GO:0008053 mitochondrial fusion biological_process
GO:0016021 integral component of membrane cellular_component
GO:0005741 mitochondrial outer membrane cellular_component
GO:0003924 GTPase activity molecular_function
GO:0005525 GTP binding molecular_function

KEGG:

id description
K06030 MFN2, FZO1; mitofusin 2

RNA

RNA id representative length rna type GC content exon number start site end site
XM_039800188.1 True 5794 mRNA 0.48 18 4030523 4059713

Neighbor

gene id symbol gene type direction distance location
LOC120558402 LOC103357835,LOC104954328 coding upstream 15922 4005265 ~ 4014601 (+)
LOC120558400 NA coding upstream 48242 3958556 ~ 3982281 (+)
LOC120559447 lactbl1,LOC103362248,LOC100707689,LOC101473793,LOC102312186 coding upstream 296132 3725961 ~ 3734391 (+)
LOC120559389 NA coding upstream 845343 3178297 ~ 3185180 (+)
LOC120558536 NA coding upstream 1203811 2825257 ~ 2826712 (+)
LOC120559787 LOC103357833 coding downstream 24981 4084694 ~ 4180336 (+)
LOC120558381 LOC100699862,LOC103374679,LOC104941073 coding downstream 194927 4254640 ~ 4258571 (+)
LOC120559099 NA coding downstream 207162 4266875 ~ 4281526 (+)
LOC120558632 LOC101473708,LOC108431628,LOC107592856 coding downstream 371675 4431388 ~ 4587064 (+)
LOC120558307 NA coding downstream 1316590 5376303 ~ 5387260 (+)
G47062 NA non-coding upstream 11444 4015192 ~ 4019079 (+)
G47045 NA non-coding upstream 94933 3934329 ~ 3935590 (+)
LOC120559454 NA non-coding upstream 104658 3920578 ~ 3925865 (+)
G47006 NA non-coding upstream 149523 3878792 ~ 3881000 (+)
G46997 NA non-coding upstream 158384 3870375 ~ 3872139 (+)
G47113 NA non-coding downstream 14315 4074028 ~ 4074900 (+)
LOC120558383 NA non-coding downstream 199106 4258819 ~ 4264632 (+)
LOC120558318 NA non-coding downstream 599753 4659466 ~ 4666871 (+)
LOC120559518 NA non-coding downstream 702676 4762389 ~ 4766774 (+)
LOC120559496 NA non-coding downstream 709567 4769280 ~ 4772306 (+)
gpr173 LOC104932793,LOC101475032,LOC100694027,LOC104957049 other upstream 164725 3843064 ~ 3865798 (+)
LOC120559404 NA other upstream 515765 3448104 ~ 3514758 (+)
LOC120559414 NA other upstream 725886 3279361 ~ 3304637 (+)
LOC120559392 NA other upstream 742434 3146481 ~ 3288089 (+)
G46574 NA other upstream 1260070 2745898 ~ 2770453 (+)
LOC120559501 NA other downstream 713219 4772932 ~ 4775358 (+)
G47444 NA other downstream 2139333 6199046 ~ 6200594 (+)
ccm2l ccm2l,LOC102778549 other downstream 2638280 6697993 ~ 6720932 (+)
G47903 LOC104965021 other downstream 4052728 8112441 ~ 8116228 (+)
pkig pkig other downstream 4283037 8342750 ~ 8380578 (+)

Expression


Co-expression Network