si:ch73-383l1.1 (erbb4a,erbb4,LOC107705456,LOC108440448,LOC107674013,LOC107702505,LOC107707608,LOC107667809)


Basic Information

Item Value
gene id si:ch73-383l1.1
gene name erbb4a,erbb4,LOC107705456,LOC108440448,LOC107674013,LOC107702505,LOC107707608,LOC107667809
gene type coding
species tiger barb (Puntius tetrazona)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_056699.1
NCBI id CM032068.1
chromosome length 31761587
location 5440065 ~ 5562873 (+)
genome version ASM1883169v1_2021_tiger_barb_Genome

Sequence

>XM_043247655.1
CCATCGAGGTAATGAAATGGTTACAAGTCGTTCAATCCGGATAATAAGACACAATTACTTTTCAAAAAAGCGAAAACAGCGCAAACGCAAGCCAGTCCAGCTGTGTTTATTGTAACAGAATGCGCTGTGGAACGAAGACGTAAGTGCGCGCGCTGGAGACGCAGACGCTGGACTGTCAATGCCCGGATTCTCTATTGATCATGCTAATGTATGGAGATATAACTTCTTAAAATAAGCAGAAATGTGGTCGGCGcgcttttttctcttcttctgccTCGTCTTCATAACTATGGTGGTTCAGAGGAGCAGCGGGCAGTCAGTGTGTCCTGGCACTGATAACAAGCTCAGCACGCTGTCGGATTTGGACCAGCAGTACAAAACTCTTCGCAAGTTCTACGAGAACTGTGAGGTGGTCATGGGTAACCTGGAGATCACCAGCATTGAAAGAAACCGCAATCTGTCTTTCCTCAAGTCCATCCGTGAGGTGACGGGATACGTGTTGGTGGCTCTGAATCAGTTTGACTATCTTCCTCTGGAGAACCTGCGGATCATCCGAGGCACTAAACTGTATGAAGGACGATACGCTCTGGCCATCTTTCTCAACTACAGACGAGATGGCTACTTCGGCCTCAGACAACTCGGACTCAAGAACCTGACAGAAATCCTGAATGGAGGTGTGTATGTGGATCAGAACAAGTTCCTGTGTCACGCTGACACCATCCACTGGCAGGACATCATCAAGAACCCGCGTTCTGAGCTTCTGGTCGTGCCCTCAAACAACAGTGGAAACACATGCAGAAGGTGTCATCGCTCCTGTAACGGCCGCTGTTGGGGCCCTCAAGAGAATCAGTGCCAAAGCTTGACAAAGACGGTGTGCGCAGAGCAGTGTGATGGACGCTGTTTCGGTCCGTACGTCAGTAACTGCTGTCACCGTGAATGTGCAGGAGGCTGTTTTGGACCCAAAGACACCGACTGCTTCGCTTGTACCAACTTTAATGACAGCGGGGCCTGTGTGACGCAATGTCCTCAGCCATTCGTCTACAATCCAACAACCTTCCAGCTCGAGCACAATCCCAACGCCAAATACACCTATGGAGCGTTCTGTGTCAAGAAATGCCCACATAACTTTGTGGTGGATCACAGCTCTTGTGTCAAAGCCTGTCCGAGCAACAAGATGGAGGTGGAGGAAAATCATATCAAGATGTGCATCCCGTGCACTGACATCTGTCcgaaaaTGTGTGACGGTATAGGCACCGGCAAGCTTCAAACGGCTCAAACTGTAGATTCCAGCAACATTGAGATGTTTGTCAACTGCACCAAGATCAACGGCAACCTCATCTTCCTCATCACAGGCATTAAAGGAGACATGTATCATGGTATCggggctctggatcctgagcGACTGAATGTGTTCCAGACCGTCAGAGAGATCACAGGTTACTTGAACATCCAGTCTTGGCCAGAGAACATGACTGATCTTGGTGTCTTTTCCAACCTTGTCACCATAGGAGGAAGAACACTTTATAGtggTATTTCTCTGCTGATCCTGAAGCAGCGCTGGATCTCTTCGCTGAAGTTTCAGTCTCTGAAAGAGATCAGCGCCGGTAACATCTACATGACCAACAACAGCCAGCTCTGCTTCTACAACACGGTGAACTGGACCAGTCTGTTCCGCACCAGCACCCAGAGAGCTCTGATCAAGAACAACAGGGACCCCAGAGACTGCACTCAGCAAAGGATGGTGTGTGATCCGTTGTGTTCGGTGGCAGGATGCTGGGGTCCCGGTCCAGATCAGTGTCTAGCTTGCAAATATTTCAGCCGGGGAAAGACATGCGTGAAAGCCTGTAATCTCTATGATGGAGATGTCCGCGAGTTTGCCAATGGATcggtgtgtgtggagtgtgacAGCCAGTGTGAAAAGGCCGAAGATAAAACTTTTACCTGTCATGGCCCTGGTCCAGATCACTGTGTGAAGTGCTTGCATCTCAAAGATGGACCCAACTGTGTGGAGAAATGCCCTGATGGTCTTCAGGGAGCAAACAGCTTCATCTTCAAATATGCTGAGACCAACAACGAGTGCCATCCGTGCCACCCCAACTGCACCCAGGGGTGTACTGGCCCCCGGATTCAAGATTGTATCGGGATGCTGGACAGGACTCCTCTGATTGCAGCTGGGGTGATTGGGGGGATGTTTGTGGTCGTAATTGTGGCCCTCGGATTTGCTATATTTTTCCGAAGGAAGAGCATCAAGAAGAAAAGAGCTTTACGCCGTTTCCTGGAAACAGAGCTGGTGGAGCCTTTAACCCCAAGCGGCACGGCGCCCAACCAGGCACAGTTGCGTATACTGAAAGAAACAGAGCTTAAGAGGGTCAAGATCTTGGGTACAGGAGCTTTTGGCACTGTTTACAAGGGAATTTGGGTTCCTGAAGGAGAAACTGTGAAGATTCCAGTGGCCATAAAGATACTCAGTGAAAGCACAGGACCAAAAGCCAATGTAGAGTTCATGGATGAGGCACTGATCATGGCCAGCATGGAGCATCCTCATCTAGTGCGTCTTTTAGGGGTCTGCTTGAGTCCCACTATTCAGCTGGTAACTCAACTCATGCCCCACGGCTGCCTGCTGGACTACGTACATGAACACCAGGAGAACATCGGCTCCCAGCTGCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGTATGATGTACCTGGAGGACAGGCGTCTGGTGCACAGGGACCTCGCGGCCCGTAACGTCCTGGTGAAATCTCCAAACCACATCAAGATCACTGATTTTGGACTCGCTCGACTGCTGGAAACCGATGAAAAAGAGTACAGCGCAGACGGAGGCAAGATGCCCATTAAGTGGATGGCCCTTGAGTGCATTCACTACAGGAAGTTCACAAATCAGAGTGATGTATGGAGCTATGGTGTGACTATCTGGGAGCTGATGACGTTCGGAGGAAAGCCCTACGATGGGATTCCCACACGCGAGATTCCAGACATCTTGGAGAAGGGCGAGCGTTTGCCCCAGCCGCCCATCTGCACCATAGACGTCTACATGGTGATGGTCAAATGCTGGATGATCGATGCTGATAGTCGGCCTCGGTTTAAAGAACTCGCTGCAGAGTTCAGCCGCATGGCACGAGACCCTCAGAGATACCTCGTCATACAGGGGGACGATCGCATGAAGCTTCCCAGCCCCAACCACAGTAAGTTCTTCCAGAGTCTTCTCGATGAGGAGGAGCTGGATGACCTGATGGACGCAGAGGAGTACTTGGTTCCTCATTCCTTAAATGCTCTTCCCACTTCCCATATGCCCCACCCACATGTAGATTCAAATCAAAACCAGTTTGCGTATCATGATGGAAGTTTGTGCTCTGAAGAGGCGATGGGATCCCGACCTCATGAAGCAGTTGCTACGGGAAGTGGCCCCTCTGTCCCGGCGGGCGTACAAAGATCAGGTTTGGATTCAGCAGATGAACAACACTGTAACGGAAGCTTGAAGAAACAGCCCACCGCTCACTCAGTAGAGGACAGCAGTGGACAGCGTTACAGCGCAGACCCAACTGTCCTACTGGGAGAGAAAGGACAGAGGGAAGATACAGATGAGGATGGCTATATGTCCCCTATGAAGGACAAGATCTCCACAAATCATCTGAACCCCGTTGAGGAGAATCCTTTTGTAACGAGGCGTAAAACTAAAGACATTCACGCACTAGACAACCTGGGTTACCACAGCACTCCTGATGGGAAGCCCAAGTGTGAAGACGAGTATATCAACGAGCCCCTTTACCTCAACACATTCAATAACACCAGCGGCATGAACCAGGAGATGTTAAGAAAAAATGGAGTCTCCGTCCCATTGCAGGTGACCACAGCAGCCCACACTCAAGCCACCCATGTCCCCCACATGACACAAATGGGAAAACTCCATCATCACAGCCACGGACCGCACGTTCATTTCGCCATACCCCCAGTTCAGCCTGTACACCCCGGACCCATGAGCCAAAATGATCAGTCAGTTCTTGATCACGGCAGCAAATCTGTCCTGCCAGCAACAGCAGGTCAGATCTGTCTAGTGAGCCATCAAGTCCAACCAGGGCACCCAAGCAAATCTAATCGTTCGCCACAACAGTTTCACTTGGCGAAGTCTGGCAAAGGTGGCACGATGGGCTTACCGGGTCATTCGGTGCAACCAGGCACCACATTAGTGGACAAGATGTACAAGAATAGCTTTGACAATCCTGAGTATTGGCAGCAAAGCCTCCCGCCCAAGGTTATCCCTCAAAACTCCCAAGACTCTTCGGTGATCTGCAATAACAAGTTCCTTTACAAGCAGAATGGCCGCATACAGCCTGCCGTGGCTGAAAACCCCGAATATCTGTCTGGTATGAAGCCAGGAACAGTCCTGCCTCCTCCTCCGTACCGGCAGAGAAACACTGTGGTCTAACGTCCAGGTCTCCATGCTCTGTAGAGCCTGGTTCTTCTACCAGCACCTTAAATGTCTTTCCTTGATCCTCTGGTGGTCAAAAATGGGACGAGAAACAATGTAAGCCACTGAACTGACAttatgtaacataaaatatgacatataaAACCACTGGGGAAAGGTCAACGCAACCCATCCATCCACAAAGACCTCATCATGTCcaggacctttttttttcctcctctacAGGTATTTTAAAGTCTCTCATATGGGATGGCACATAATCCGATTTATTAACATCATTCATTTGGTGAaattagatattaaaaacaaaaatttcacAGCAATTCCATTTAACTTTGGTGTCCAGTTCTGCTTCTTGAGGGCCAATATCTTGCTACATTTAGCTTCAAGTAGCTCCAACACGCTTACCTGGTATTTCCTAGTGAATCTGAAAACCTTGATTAatttggttcaggtgtgtttaattagggttggagctaaaatCCTGAAGaacagtggccctccaggaacagTTTTGAATGCCCCCACTATGGAACCTTTCAAGTAAAATTTTCCCTTTGTGTGGAGAACTTTTTTCCACTATAAAACCTTTTGTGCGATAGAAAGATTCCatgaatgttaaatgtaattcatgGAACCATAGATGCCAATGAAGGGataattttactgtttatttttaagagtgtacagTAGGTGGTTTTACCTGTGGTTCA

Function

symbol description
erbb4a Predicted to enable epidermal growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within generation of neurons. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in heart and nervous system. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4).
erbb4 Enables several functions, including epidermal growth factor receptor binding activity; protein homodimerization activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including positive regulation of phosphorylation; positive regulation of signal transduction; and protein phosphorylation. Located in basolateral plasma membrane; mitochondrion; and nucleus. Part of receptor complex. Implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Biomarker of carcinoma (multiple); ductal carcinoma in situ; reproductive organ cancer (multiple); and urinary bladder cancer.

NR:

description
PREDICTED: receptor tyrosine-protein kinase erbB-4-like

GO:

id name namespace
GO:0006468 protein phosphorylation biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0016020 membrane cellular_component
GO:0005524 ATP binding molecular_function
GO:0004714 transmembrane receptor protein tyrosine kinase activity molecular_function

KEGG:

id description
K05085 ERBB4, HER4; receptor tyrosine-protein kinase erbB-4

RNA

RNA id representative length rna type GC content exon number start site end site
XM_043247655.1 True 5166 mRNA 0.49 27 5440065 5562873

Neighbor

gene id symbol gene type direction distance location
erbb4a erbb4a,erbb4,LOC107674013,LOC107707608,LOC107725343,LOC107667809,LOC107557316,LOC108440448,LOC101079286 coding upstream 145625 5157979 ~ 5294440 (+)
ube2f ube2f,LOC107725407,LOC107556276,LOC107674019,LOC107707607,LOC107566887 coding upstream 283709 5149028 ~ 5156356 (+)
si:ch211-93g23.2 si:ch211-93g23.2,LOC107725372,LOC107674017,LOC107556277 coding upstream 291175 5145908 ~ 5148890 (+)
fastkd2 LOC107673994 coding upstream 473145 4960324 ~ 4966920 (+)
retreg2 fam134a,LOC107706836,LOC107676053,LOC107556270,LOC107750069,LOC107673992 coding upstream 485022 4945839 ~ 4955043 (+)
lancl1 lancl1,LOC107564761,LOC107702553,LOC107590692 coding downstream 30769 5593642 ~ 5600055 (+)
mylz3 mylz3,LOC107725378,LOC107564772,LOC107701775,LOC107702554,LOC107705457 coding downstream 40834 5603707 ~ 5607415 (+)
LOC122347193 pcnp,LOC107564735,LOC107590694,LOC107702552 coding downstream 45456 5608329 ~ 5610739 (+)
en1b eng1b,en1,LOC107705463,LOC107702516 coding downstream 105524 5668397 ~ 5672318 (+)
LOC122347080 NA coding downstream 216824 5779697 ~ 5782861 (+)
LOC122344626 NA non-coding upstream 31767 5404612 ~ 5408298 (+)
G1036 NA non-coding upstream 283084 5156722 ~ 5156981 (+)
LOC122346173 NA non-coding upstream 301211 5127490 ~ 5138854 (+)
G1016 NA non-coding upstream 338743 5038720 ~ 5101322 (+)
G948 NA non-coding upstream 462151 4977422 ~ 4977914 (+)
G1064 mxa,mx1,LOC107702551 non-coding downstream 30341 5593214 ~ 5626276 (+)
G1061 NA non-coding downstream 51514 5614387 ~ 5622881 (+)
G1060 NA non-coding downstream 52847 5615720 ~ 5623944 (+)
G1086 NA non-coding downstream 111499 5674372 ~ 5674683 (+)
G1091 NA non-coding downstream 175014 5737887 ~ 5789576 (+)
hecw2b hecw2,LOC107674007,LOC107676038,LOC108258347,LOC107706834 other upstream 414151 4979125 ~ 5025914 (+)
gtf3c3 gtf3c3,LOC107706835,LOC107750061 other upstream 462802 4967186 ~ 4977263 (+)
prkag3a prkag3a,LOC107750059,LOC107673997,LOC107676055 other upstream 495224 4938181 ~ 4944841 (+)
G826 NA other upstream 1081769 4358007 ~ 4358296 (+)
G824 NA other upstream 1082805 4356698 ~ 4357260 (+)
G1168 LOC107725347,LOC107565259,LOC107701771 other downstream 316587 5879460 ~ 5881134 (+)
G1183 actb,actb1,LOC102799139,LOC107581721,LOC103039558 other downstream 494531 6057404 ~ 6087655 (+)
G1318 NA other downstream 722985 6285858 ~ 6287198 (+)
G1414 NA other downstream 970629 6533502 ~ 6536957 (+)
G1447 fga,LOC107692636,LOC107565125,LOC107714149,LOC107758872,LOC108439170 other downstream 1148762 6711635 ~ 6845548 (+)

Expression


Co-expression Network