LOC103028095 (itgb3b,itgb3,LOC108430317,LOC107698806,LOC107706862)


Basic Information

Item Value
gene id LOC103028095
gene name itgb3b,itgb3,LOC108430317,LOC107698806,LOC107706862
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035902.1
NCBI id CM008305.1
chromosome length 52532229
location 18696994 ~ 18728233 (-)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_022670315.1
TCCCCAGAGGTTCAAGCTGCAGGTGCGACAGGTGGAGGACTACCCTGTCGACCTGTACTATCTGATGGACCTGTCGTACTCCATGAATGATGACCTGTCTCAGCTTAGGAGACTCGGAAAGGGTCTGGCGGAGGAGATGAGTAAAACCACCAGCAATCTCCGAATGGGTTTTGGGGCTTTCGTGGATAAACCTGTGTCTCCGTACATGTACATCTCTCCACCAGAAGCTGTGAAGAACCCATGCTACTCAATCCCGTTTAAATGCCAGCCGCAGTTTGGCTACAGGCACGTGCTGTCGCTGACGGATGAAGTGGGTCGCTTCACAGAGGAGGTGAAGAAGCAGAAGGTTTCTCGTAATCGTGACGCTCCGGAGGGGGGATTTGACGCCATCATACAGGCAGCCGTGTGTAAGGACAAGATTGGTTGGCGGCCGGATGCTTCCCACCTGCTGGTGTTCACTACTGATGCTAAGACTCATGTAGCGCTGGACGGACGCTTGGCGGGCATTGTGCGACCTAATGATGGCCAGTGCCATGTGGGCGAAGACAACGTCTACAACATGTCTACTACAATGgaCTACCCATCCCTTGCTCTGATCACGGAGAAGATGTCTGAGAACAACATAAACCTCATCTTTGCTGTCACCAATCCTGTTGTACCTCTTTACAAGAATTACAGTGATCTAATCCCGGGTACAGCAGTGGGAACTCTGTCTGAGGACTCACGCAATGTCATCCAACTGATCCAAGATGCTTATGCTAAAATTCGCTCTAAGGTTGAGCTGGAGCTCTTGAATGTTCCAGAAGAGCTGAGTCTCTCCTTCACTGCAACGTGTCTGAATGGGGAGGTGATACCAGGTCTCAAGTCCTGCTCTGGACTCAAAAGAGGAGATACGGTATCCTTCAGCGTAGAGGCTCGTGCGAGGGGCTGCCCCAAAGAGAAGCGCAAGACTTTCACCATCAAACCCGTGGGCTTCAAAGACGCTCTGCAGATCACCGTCGACTTCGAGTGCCAGTGTAAGTGCCAGGCTCTGGGCGAGCCCGACAGTCCCGTGTGCCACCACGGCAATGGCACCTACGAGTGTGGCATCTGCATGTGCCACCCCGGCCGCCTGGGCCCCAGGTGTGAGTGTGCGGAGGGAGACTACAGCCCCAGCGAGCAGGACACCTGCAGCGGCCCAAACAAGGTGGTGTGCAGTGGCCGgggagactgtgtgtgtggtcagtgtgtgtgtcacaACAACGACTTCGGCAAGGTGTGGGGGAAGAGGTGCGAGTGTGATGACTTCAGCTGCCTGAGGTATAAAGGAGAGCTGTGCTCAGGTCACGGCACATGCTCGTGTGGGTTCTGCCAGTGTGACCCGGACTGGTCGGGTGAGAACTGTAACTGCTCCACACGTCTGGACACCTGCATGTCCACCACAGGCTCCCTGTGCAGCGGCCGAGGGCAGTGTGTGTGCGGCAGCTGTGAGTGTACCCAGCCCGGGGCCTACGGATCCACCTGTGATAAATGCCCCACCTGCCCTGATGCCTGCACCATGAAGAAGGACTGTGTGGAATGTAAGCATTTTAAACGAGGTGCGCTGTTTGAGGACGACAGCTGTGCTCGCATTTGCAGAGATGAGATTGTGCTGGTTGATGATCTGGTTCTCCACGACAAGAATGCTGTGAACTGTACCTACAAGGACGAGGATGATTGTGTGCAGAGGTTCCAGTACTTTGAAGATAACAGCGGGAAGTCTATTCTGTCTGTGGTGAAAGAGCCAGACTGTCCTAAAGGCCCTGATATCCTGGTGGTGCTGCTCTCGGTTGCTGGCGCTATACTGTTCCTGGGTCTCGCCGCCTTGCTGATCTGGAAACTGCTGGTGACCATCCACGACCGCCGCGAGTTCGCCAAATTCGAGGAGGAGCGAGCAAAAGCCAAATGGGACACGAGCCACAACCCTCTCTACAAAGGAGCCACGACCACTTTCACCAACATCACCTACCGAGGAAAAGACTAACAGACCCTCACCATCGTCACTGCAGCTGCAGCCATGCGGGAATTTAttaataactgtaaaaaaaaaatactgttatcaTTTTATATTTGGAGGATGTACATTTTCtgtctgtaaataataatatgacAGGTGGTTTAATGAAGTATCTTGTATTTAGTCATCACACGTTTTGATGATTGCAGTCAGTGTATTATGCATTCTGtgtttttggtaccactttaaaataagactaccttcataaagggtttatacaatagtttattaatg

Function

symbol description
itgb3b Predicted to enable fibronectin binding activity and integrin binding activity. Predicted to contribute to fibrinogen binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to act upstream of or within platelet aggregation. Part of integrin complex. Is expressed in brain; cardiovascular system; dental epithelium; digestive system; and pectoral fin fold. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (integrin subunit beta 3).
itgb3 Enables several functions, including fibronectin binding activity; protein disulfide isomerase activity; and signaling receptor binding activity. Contributes to C-X3-C chemokine binding activity and growth factor binding activity. Involved in several processes, including apolipoprotein A-I-mediated signaling pathway; negative regulation of lipid localization; and positive regulation of protein phosphorylation. Acts upstream of or within negative regulation of low-density lipoprotein receptor activity. Located in several cellular components, including cell projection membrane; focal adhesion; and melanosome. Part of several cellular components, including alphav-beta3 integrin-HMGB1 complex; alphav-beta3 integrin-IGF-1-IGF1R complex; and alphav-beta3 integrin-PKCalpha complex. Is active in glutamatergic synapse. Implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Biomarker of several diseases, including Graves' disease; carcinoma (multiple); diabetic retinopathy; myelodysplastic syndrome; and platelet-type bleeding disorder 16.

NR:

description
PREDICTED: integrin beta-3-like

GO:

id name namespace
GO:0070527 platelet aggregation biological_process
GO:0007229 integrin-mediated signaling pathway biological_process
GO:0007044 cell-substrate junction assembly biological_process
GO:0030334 regulation of cell migration biological_process
GO:0007160 cell-matrix adhesion biological_process
GO:0060055 angiogenesis involved in wound healing biological_process
GO:0008305 integrin complex cellular_component
GO:0005515 protein binding molecular_function

KEGG:

id description
K06493 ITGB3, CD61; integrin beta 3

RNA

RNA id representative length rna type GC content exon number start site end site
XM_022670315.1 True 2269 mRNA 0.52 12 18696994 18728233

Neighbor

gene id symbol gene type direction distance location
LOC103024498 ndel1a,LOC108430325,LOC107706877,LOC107698805,LOC107582761,LOC107700135 coding downstream 7393 18656832 ~ 18689601 (-)
nat9 nat9 coding downstream 48119 18644455 ~ 18648875 (-)
grem2 grem2,grem2b,LOC107746751,LOC107570400,LOC107659701 coding downstream 86575 18581880 ~ 18610419 (-)
LOC103035822 NA coding downstream 1027269 17668664 ~ 17669725 (-)
LOC103035515 NA coding downstream 1031733 17648451 ~ 17665261 (-)
LOC111192624 LOC108430317 coding upstream 1810 18730043 ~ 18741304 (-)
LOC111192707 NA coding upstream 394387 19122620 ~ 19143280 (-)
LOC103025356 NA coding upstream 709400 19437633 ~ 19459375 (-)
LOC103036701 LOC108430450 coding upstream 877322 19605555 ~ 19670670 (-)
LOC103034301 prkcea,LOC108430457,LOC108274197,LOC107550054,LOC107739250,LOC107698816 coding upstream 954158 19682391 ~ 19839582 (-)
G53175 NA non-coding downstream 50118 18645879 ~ 18646876 (-)
G53139 NA non-coding downstream 293594 18402279 ~ 18403400 (-)
G53135 NA non-coding downstream 297846 18350272 ~ 18399148 (-)
G53138 NA non-coding downstream 310002 18385769 ~ 18386992 (-)
G52995 NA non-coding downstream 507327 18189467 ~ 18189667 (-)
G53184 NA non-coding upstream 49928 18778161 ~ 18867587 (-)
G53185 LOC108430338 non-coding upstream 50481 18778714 ~ 18786708 (-)
G53199 NA non-coding upstream 120496 18848729 ~ 18892877 (-)
G53209 NA non-coding upstream 199093 18927326 ~ 18927932 (-)
LOC111192726 NA non-coding upstream 389233 19117466 ~ 19120375 (-)
G53164 NA other downstream 29707 18586401 ~ 18667287 (-)
G52652 NA other downstream 2107211 16588150 ~ 16589783 (-)
zcchc4 NA other downstream 2269381 16406719 ~ 16427613 (-)
LOC111192725 NA other downstream 2340034 16343756 ~ 16356960 (-)
G52503 polr2a other downstream 2469820 16226236 ~ 16227174 (-)
LOC103025665 glud1b,LOC108430434,LOC107698813,LOC107700126,LOC107739271,LOC107550058,LOC107749346 other upstream 794469 19522702 ~ 19570378 (-)
G53382 NA other upstream 1121717 19849950 ~ 19850350 (-)
G53562 LOC107396020,LOC107670363,LOC105896953,LOC102778633 other upstream 1893336 20621569 ~ 20690422 (-)
G53598 msh2,LOC107728724,LOC107673650,LOC107582784,LOC107550043,LOC107749362,LOC107698830 other upstream 2055505 20783738 ~ 20787618 (-)
G53607 fbxo11,fbxo11b,fbxo11a,LOC107749363,LOC107550041,LOC107728720 other upstream 2089606 20817839 ~ 20819409 (-)

Expression


Co-expression Network