XLOC_000083 (ERBB4)


Basic Information

Item Value
gene id XLOC_000083
gene name ERBB4
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007112.7
NCBI id CM002885.2
chromosome length 59578282
location 7189856 ~ 7448795 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00000157
CTCTTTGTCATGACAAATTCAAAATCCTGACATAGCAGGTGTATATGCTAAACAGCCATATGGAGGGCGTGGTCTCGTCTGCTAAAACGCATCTTTTGACCATTCCCATATCAGATAGGCGGTGCTCCGCACAAAATGGGCGTGTCTTTACGCTCAAACCGAAGTTGTGAATCCATCGAGGTAATGAAATGGTTACAAGTCCTTCAGTCCGGATAATCAACcacaattacttaaaaaaaacagctaacaGCCCAAAAAGCCAAACAGTCCAGCTGTGATTATTGACAAAGGATGTGCTCTGAAACGAAGACGTGAGTGAGTGCGCGCGCTGGAGACTCAGACGCTGGACTGTCAATGCCCGGATTCTCTATTGATCATGCTAATGTGTGGGGATATAACTTCTTAAAATAAGCAGAAATGTGGCCGGTTCGCTTCCTTCTCCTCTTCTGCCTGGTCTTCACGTTTGCGGTGCTTCAGAGGAGCAGCGGGCAGTCAGTGTGTCCTGGCACTGATAACAAGCTCAGCACACTGTCGGATTTGGACCAGCAATACAAGACTCTTCGCAAGTTTTATGAGAACTGTGAGGTGGTCATGGGTAATCTGGAGATCACCAGTATTGAGAGGAACCGGAACCTGTCTTTCCTCAAGTCTATCCGGGAGGTGACGGGTTACGTGTTGGTGGCTCTAAACCAGTTTGACTATCTTCCTCTTGAGAACCTGCGAATAATCCGAGGCACTAAACTCTACGAAGGACGCTACTCTCTGGCCATCTTTCTCAACTACAGACGAGACGGCTACTTCGGCCTGAGACAGCTCGGCCTCAGGAACCTGACAGAAATCCTGAATGGAGGTGTGTATGTGGATCAGAATAAGTTCTTGTGTCATGCGGACACCATCCACTGGCAGGACATCATCAAAAACCCTCGATCTGAACTTCTGGTTGTGCCGTCGAACAATAGTGGGAACACATGCAGAAGGTGCCATCGCTCCTGTAACGGCCGCTGCTGGGGTCCTCAGGAGGATCAGTGCCAGAGCTTGACGAAGACGGTGTGTGCGGAGCAGTGTGACGGTCGATGTTTTGGACCGTATGTCAGTAACTGCTGTCACCGTGAATGTGCAGGGGGCTGTTTCGGACCCAAAGACACAGACTGCTTTGCTTGCACCAACTTTAATGACAGTGGTGCCTGCGTGACTCAATGTCCTCAACCATTCGTCTACAATCCAACGACCTTCCAGCTCGAGCACAATCCCAATGCCAAATACACCTATGGAGCTTTCTGTGTCAAGAAATGCCCACATAACTTTGTGGTGGATCACAGCTCTTGTGTCAGAGCCTGTCCGAGCAACAAGACGGAGGTGGAGGAAAATAACATCAAGATGTGCATCCAGTGCACTGAAATCTGCCCCAAAATGTGTGATGGTATAGGAACCGGCAGCCTTCAATCAGCCCAAACTGTTGATTCCAGCAACATTGAGAAGTTTGTCAACTGCACCAAGATCAACGGCAACCTCATCTTCCTCATCACAGGCATCAAAGGAGACATGTATCATGGCATCAGGGCTCTGGATCCGGAGAGACTAAATGTTTTCCGCACCGTCAGAGAGATCACAGGTTACTTGAACATCCAGTCTTGGCCTGAAAACATGACTGACCTTAGTGTTTTTTCCAACCTTGTCACCATAGGAGGAAGAACTCTCTACAGTGGTATTTCTCTGCTGATCCTAAAGCAGCGCTGGATCACGTCTCTGCAGTTTCAGTCTCTGAGAGAGATCAGCGCTGGTAACGTCTACATGACCAACAACAGCCAGCTTTGCTTCTACAGCACAGTCAACTGGACGTCTCTGTTTCGCACCAGCACACAGAAAGCCAAGATCAAGGACAACAGAGACCCCAGAGAGTGCTCTCAACAGAGGATGGTTTGTGATCCGCTGTGCTCAGTGTCAGGATGCTGGGGGCCCGGGCCAAATCAGTGTCTGTCCTGTAAATACTTCAGCCGGGGAAGGACATGTGTGAGGTCCTGTAATTTGTATAATGGAGATGTTCGAGAATTTGCCAATGGATCTACGTGTGTGGAGTGTGACAGTCAGTGTGAAAAGGCTGAAGATAAATCTCTCACCTGTCACGGGCCTGGACCAGATCACTGTGTGAAGTGTCTGCATCTCAAAGACGGGCCCAACTGTGTGGAGAAATGCCCTGACGGTCTGCAGGGAGCAAACAGCTTTATCTTCAAATATCCCGAGACCAACAACGAGTGCCATCCCTGCCACCCCAACTGCACGCAGGGGTGTACTGGACCCCGGATCCAAGATTGTATCGGGATACTGGACAGGACTCCTCTGATTGCAGCTGGGGTGATTGGTGGGATGTTTGTGGTCGTAATTGTGGCTCTTGGATTTGCCATCTTTTTCCGCCGAAAAAGCATAAAGAAGAAGAGAGCTTTACGACGTTTCCTAGAAACTGAGTTGGTGGAGCCTTTAACACCCAGTGGCACGGCTCCTAACCAGGCACAGTTACGCATACTGAAGGAAACTGAGCTCAAGAGGGTCAAGATCTTGGGAACTGGAGCATTTGGCACTGTTTACAAGGGAATCTGGGTTCCAGAAGGGGAAACTGTGAAGATTCCTGTGGCCATAAAGATACTCAATGAAAGCACGGGACCTAAAGCCAATGTGGAGTTTATGGATGAGGCGCTGATCATGGCCAGTATGGAGCATCCTCATCTGGTGCGTCTTTTAGGGGTCTGCTTGAGTCCCACTATTCAGCTGGTGACTCAGCTCATGCCCCACGGCTGCCTGCTGGACTACGTTCATGAACACCAGGACAACATCGGCTCACAGCTGCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGTATGATGTATCTGGAGGAGAGACGGCTAGTGCACAGGGATCTCGCGGCTCGTAATGTGCTGGTTAAATCTCCAAACCACATCAAGATCACTGATTTTGGACTCGCTCGACTGCTGGAAACCAATGAAAAGGAGTACAGTGCGGATGAAGGCAAGATGCCCATCAAGTGGATGGCTCTGGAGTGTATTCACTATAGGAAGTTTACACACCAGAGTGATGTATGGAGCTACGGAGTGACTATCTGGGAGCTGATGACATTTGGAGGAAAGCCTTACGACGGGATTCCCACACGGGAGATTCCAGACATCCTGGAGAAAGGCGAGCGTTTGCCTCAGCCGCCCATCTGCACCATAGATGTCTACATGGTCATGGTCAAATGCTGGATGATTGATGCCGATAGTCGTCCACGTTTTAAAGAACTGGCCGCAGAGTTCAGCCGTATGGCCCGAGACCCGCAGAGATACCTCGTCATACAGGGAGATGATAGGATGAAGCTGCCCAGCCCAAACCATAGCAAGTTCTTCCAGAGTCTTCTAGATGAGGAGGAGCTGGACGACCTGATGGACGCTGACGAGTACCTGGTTCCTCATTCCCTAAATGCCCCTCCTACTTCCCATATACCACACCCACATGTAGATTCAAATCAGAATCAGTTTGGGTATCATGATGGAAGTCGGTGTCCTGAGGACGTAACGAGGTTTCATGAAGTGGCTGCTGCTGGAAACGCACCCTCTGCTCTTGGAAGTGCACAAAGAGCAGGTCTGGATCTGGTGGAGGAGCAACACTGTAATGGCAGCTTGAAGAAACAGGCCACGGTTCATTCAGTGGAGGACAGCAGTGGCCAACGTTACAGCGCAGACCCCACTGTCCTGCTGGGAGAGAAAACACAGAGAGAGGATACAGATGAGGATGGGTACATGTCCCCTATGAAGGACAAGATCTCCACAAATCATTTGAATCCAGTTGAGGAGAATCCTTTCGTAACAAGACGCAAAAGCAAAGACGTTCATGCATTGGACAACCCGGGTTACCACAACACCCCTGACGGAAAGCCCAAATGTGAAGACGAGTACATTAACGAGCCCCTTTACCTCAACACGTTCAACAACACCAGCGACATCCACCAGGAGATGCTACGGAAGAACGGAGTCTCCATCCCAGCACAGATGACCACAGCTGGCCACATCTTACAGACGGGTAAACCCCATCACCACAGCCATGGGCCGCATGTTCACTTCGCCATACCTCCAGTCCAGCCGGTGCACCCTGGACCCATGAGCCAAAATGATCACAATGCACATTCAGTTCAGTCAGGCCACGATCACGCCGTCAAATCCGGCCCATCAGCAGGTCAGATCTGTCTAGTGAGCCATCAAGTCCAACAGGGACATCCGAGCAAATCCAACCGTTCACCACAACAGTTTCAATTATCAGGAGGTAAACTACCAGGTCATCCAGTGCAGCCAGGCAGCCAGATTGGGACTGTATTAGTGGACAAGATGTACAAGAACAGCTTTGACAATCCGGAGTATTGGCAGCACAGCCTTCCTCCACCTCAAATCTCCCAGGACTCTTCTTCTGCGGTCTGCAATAACAAGTTCCTTTACAAGCAGAATGGCCGCGTTCAGCCTCCTGCGGCAGAAAACCCTGAATATCTGTCTGGTGTGAAGCCGGGAATGGTCCTGCCGCCTCCTCCGTACCGGCAGAGGAACACTGTGGTCTAA
>TCONS_00000158
TTGGTGGAGCCTTTAACACCCAGTGGCACGGCTCCTAACCAGGCACAGTTACGCATACTGAAGGAAACTGAGCTCAAGAGGGTCAAGATCTTGGGAACTGGAGCATTTGGCACTGTTTACAAGGGAATCTGGGTTCCAGAAGGGGAAACTGTGAAGATTCCTGTGGCCATAAAGATACTCAATGAAAGCACGGGACCTAAAGCCAATGTGGAGTTTATGGATGAGGCGCTGATCATGGCCAGTATGGAGCATCCTCATCTGGTGCGTCTTTTAGGGGTCTGCTTGAGTCCCACTATTCAGCTGGTGACTCAGCTCATGCCCCACGGCTGCCTGCTGGACTACGTTCATGAACACCAGGACAACATCGGCTCACAGCTGCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGTATGATGTATCTGGAGGAGAGACGGCTAGTGCACAGGGATCTCGCGGCTCGTAATGTGCTGGTTAAATCTCCAAACCACATCAAGATCACTGATTTTGGACTCGCTCGACTGCTGGAAACCAATGAAAAGGAGTACAGTGCGGATGAAGGCAAGATGCCCATCAAGTGGATGGCTCTGGAGTGTATTCACTATAGGAAGTTTACACACCAGAGTGATGTATGGAGCTACGGAGTGACTATCTGGGAGCTGATGACATTTGGAGGAAAGCCTTACGACGGGATTCCCACACGGGAGATTCCAGACATCCTGGAGAAAGGCGAGCGTTTGCCTCAGCCGCCCATCTGCACCATAGATGTCTACATGGTCATGGTCAAATGCTGGATGATTGATGCCGATAGTCGTCCACGTTTTAAAGAACTGGCCGCAGAGTTCAGCCGTATGGCCCGAGACCCGCAGAGATACCTCGTCATACAGGGAGATGATAGGATGAAGCTGCCCAGCCCAAACCATAGCAAGTTCTTCCAGAGTCTTCTAGATGAGGAGGAGCTGGACGACCTGATGGACGCTGACGAGTACCTGGTTCCTCATTCCCTAAATGCCCCTCCTACTTCCCATATACCACACCCACATGTAGATTCAAATCAGAATCAGTTTGGGTATCATGATGGAAGTCGGTGTCCTGAGGACGTAACGAGGTTTCATGAAGTGGCTGCTGCTGGAAACGCACCCTCTGCTCTTGGAAGTGCACAAAGAGCAGGTCTGGATCTGGTGGAGGAGCAACACTGTAATGGCAGCTTGAAGAAACAGGCCACGGTTCATTCAGTGGAGGACAGCAGTGGCCAACGTTACAGCGCAGACCCCACTGTCCTGCTGGGAGAGAAAACACAGAGAGAGGATACAGATGAGGATGGGTACATGTCCCCTATGAAGGACAAGATCTCCACAAATCATTTGAATCCAGTTGAGGAGAATCCTTTCGTAACAAGACGCAAAAGCAAAGACGTTCATGCATTGGACAACCCGGGTTACCACAACACCCCTGACGGAAAGCCCAAATGTGAAGACGAGTACATTAACGAGCCCCTTTACCTCAACACGTTCAACAACACCAGCGACATCCACCAGGAGATGCTACGGAAGAACGGAGTCTCCATCCCAGCACAGATGACCACAGCTGGCCACATCTTACAGACGGGTAAACCCCATCACCACAGCCATGGGCCGCATGTTCACTTCGCCATACCTCCAGTCCAGCCGGTGCACCCTGGACCCATGAGCCAAAATGATCACAATGCACATTCAGTTCAGTCAGGCCACGATCACGCCGTCAAATCCGGCCCATCAGCAGGTCAGATCTGTCTAGTGAGCCATCAAGTCCAACAGGGACATCCGAGCAAATCCAACCGTTCACCACAACAGTTTCAATTATCAGGAGGTAAACTACCAGGTCATCCAGTGCAGCCAGGCAGCCAGATTGGGACTGTATTAGTGGACAAGATGTACAAGAACAGCTTTGACAATCCGGAGTATTGGCAGCACAGCCTTCCTCCACCTCAAATCTCCCAGGACTCTTCTTCTGCGGTCTGCAATAACAAGTTCCTTTACAAGCAGAATGGCCGCGTTCAGCCTCCTGCGGCAGAAAACCCTGAATATCTGTCTGGTGTGAAGCCGGGAATGGTCCTGCCGCCTCCTCCGTACCGGCAGAGGAACACTGTGGTCTAACGTCCAGGTCTCCATGCTCTGTAGAGCCTGGTTCTTCTACCAGCACCTTAAATGTCTTTCCGTTATCctcaaaaaaatattgaatatgaATAATGTAAGCCACTGAACTGACGttataagacaaaacaaaacaaacattgaaGGAAAAGGTCAACTCATCTCATCCAAACATTCATCCCCATTCACCCCACCGGTCACCCAAGAACTTTTTGATTTTCCTATCTACAGGTATTTTAATAAGCCTCACACAGGATGTCAATGAAGATCTGAAGCTACACTGATCGAACACTCAGTCCACACTGGAGTTAGCAAACTCAGAGAATCtctcatccacactgaaacaaTGGAACATGATGAAATCCTTGTATTGAAGGATCATTGAAATAATACTGACAGGCCAGACATGggtttatattagggctgcacgatactggaaccGTATGTGATATTTGATGTTGTTGAGTATTGCGATATTAAAATTTCTTACGATATTATGTTTcactagaaaaaaaaatgctgtttttattagctgtttttaccttatttatttatttaagagtatttaaataaacatgcacaggatattttttttcagatctaattCAGACTAAAGAAAAGTagctgccaacatttgtctcagATATTCTGGGAGATTGGGGGAGGGGGAATAGGGTGGGAGTTAAGCTGTGGTCTCACTAGACTTTTCGCGCC

Function

symbol description
erbb4 Enables several functions, including epidermal growth factor receptor binding activity; protein homodimerization activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including positive regulation of phosphorylation; positive regulation of signal transduction; and protein phosphorylation. Located in basolateral plasma membrane; mitochondrion; and nucleus. Part of receptor complex. Implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Biomarker of carcinoma (multiple); ductal carcinoma in situ; reproductive organ cancer (multiple); and urinary bladder cancer.

GO: NA

KEGG:

id description
ko04010 MAPK signaling pathway
ko04012 ErbB signaling pathway
ko04020 Calcium signaling pathway
ko04151 PI3K-Akt signaling pathway
ko05205 Proteoglycans in cancer
ko05014 Amyotrophic lateral sclerosis
ko01001 Protein kinases

Ensembl:

ensembl_id ENSDARG00000090408

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00000157 False 4596 mRNA 0.50 27 7189856 7448084
TCONS_00000158 True 2844 mRNA 0.48 10 7414318 7448795

Neighbor

gene id symbol gene type direction distance location
XLOC_000082 CABZ01075319.1 coding upstream 73942 7092273 ~ 7115914 (+)
XLOC_000081 CU929161.1 coding upstream 125913 7063837 ~ 7063943 (+)
XLOC_000080 NA coding upstream 199829 6956913 ~ 6990027 (+)
XLOC_000079 erbb4a coding upstream 264449 6817292 ~ 6925407 (+)
XLOC_000078 CU302223.1 coding upstream 402052 6787690 ~ 6787804 (+)
XLOC_000084 NA coding downstream 63734 7512529 ~ 7512762 (+)
XLOC_000085 lancl1 coding downstream 68654 7517449 ~ 7554463 (+)
XLOC_000086 pcnp coding downstream 108170 7556965 ~ 7561222 (+)
XLOC_000087 NA coding downstream 223326 7672121 ~ 7674229 (+)
XLOC_000088 en1b coding downstream 230533 7679328 ~ 7683372 (+)
XLOC_000077 NA non-coding upstream 428926 6759183 ~ 6760930 (+)
XLOC_000097 NA non-coding downstream 1124982 8573777 ~ 8575057 (+)
XLOC_000098 AL928650.2 non-coding downstream 1126512 8575307 ~ 8577274 (+)
XLOC_000100 NA non-coding downstream 1138435 8587230 ~ 8590636 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
bowfin (Amia calva) G125612 NA non-coding CM030137.1 CM030137.1 575290 ~ 575492 (+)