XLOC_008968 (rnf168)



Basic Information


Item Value
gene id XLOC_008968
gene name rnf168
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information


Item Value
chromosome id NC_007126.7
NCBI id CM002899.2
chromosome length 48040578
location 4101254 ~ 4124099 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence


>TCONS_00017688
gttttttttaatactttttatactACTGAAACTTTTAATATATGGCTGTAAAACGTTTTTAATCTTTCAGGTAATGCGTCATGAAGCCATACCAAATACGGAGCGAAGGCTTGTTATTATTTAACCATTTATTGTATGTTCTTCTACCGGctgtattgtatgtttttttttattgaatgcttgaaaaacaataacaacaaatgtcATGAATCAAACAGCAACAATCCAGGGGTCTTTAGTCATTTAGTCCAAGATGAGTGTCAAGTCCTTAATCAAAGTCCTCAAACAAGGTTGGCTGTATTGTATGTTCTTCTACTGATCTAATCCAAATGAAACAGcagtgcttttattttgaaacactGTCTTGTCGTTGCCGCCCATGGTTTCACACGCGCGGGCAGTAGGGCGCAAAATATTCCCGGGATTTTGTGGCCTTGTGAGCAAGAAAGCGCcaGACCATCTTATGCTGCGATTGACCCTGACTGAGGATCATCATTGACTGACGTACAGTGGCGGGCAGCAGGATGCCGCCTGTGTCCGAGGTGGACAGGGGTCCAGTTGAAGAAAGCTCTGGCGGTCTTAAGCGCTCAGACTGCGTTTGTCCTGTATGCCTGGAAATATTCCTGGAGCCGGTGACTTTGCCCTGCATGCACACGTTCTGCAAACCCTGCTTTCTGGAAACGGTGGACAAATCCAACATGTGCTGTCCGCTTTGCCGGAAACGCGTGTCCACTTGGGCGAGACTTAACAGCCGGAACAAGACCCTGGTCAACATGGAGCTGTGGAGACGTATTCAGGACGCCTTTCCCTCTCAGTGCGAGCGGAGGGTACAGGGAATTGATGACGATGAGGAAGCTGTGATGATTCCAAAACCTCGAGTGTGCCAGCCCGGAGAGCTGAGGAAAGAGTATGAGGATCAGATCAGCAAGCTTGTGGAGGAGAAGCGAGCCCTGGAGGAGGCTGAAAGGAGAGCCAGCGAGGAGTACATCCAGCGGCTTCTGGCAGAGGAAGAGGAGCGCTTGGAGGAAGAGAGGAGACGCAAAGAAGAGCTGCAGCTGGAGAACGATGAGAAACTGGCCAGACTGCTCAGCCTAGAACTGAATTCAGGACCAGCCTCTGAATCAACATGCAACATCAAACCTGCCGAAGCTACGCCAGCTAAGAAGAAACCAAGTGTGGGGGATATTGAGAAGTTTTTGCGTCCAGTGCCTCATAAACAGCCAAGCAGTTCTGACAGCAGCCCAGACTCCTCCCTGATGGCTAATAAGGAAAACATTCTGAGCCCTCCAAAACCCCTCTCAGCACTGTCTGCGGAGGACAGTGGTAAACTAACGGTTCACATGTTGGAATGCAATGGCAAACCCTCCACCTCCAGCTTCAATCCAAGCACCTCAGAACACACTTTTGTTTTTAACACTCCCAAAAGCAGCTCAGTGAAGCGGAAGAGTTCGGAGATCGAGCTTCAGAGCGAAGTGGATCTACATTCTAAGAGGCCTTGTGCTCCTTTGAGGTTTGACTCGTCTTCAGAAGACAGCCCTTTTCTCTCTGAAGTGGCTGTGCATGAGGAGGCCTTACGGAGCCGCTGGCAGCAAGAGGAGGAAGACCGAAGGTTGGCCTTGCGAATCCAGAAGGAGCTGAACCGCGAGAACTCTGTTGACCGCAGAAAAGGCTCAGCCGACAGCTATCAGCTCCGACAAAAGAACAATTCGGTTTCCACCACTACAAGCCCAGATGTAGAAGGTACAAAAAAGGGCAGTAACACAACAACCGCAAAGAATTGCACAGGACGCAGGGGCGAAGAGAAAACTGAAAAGAGACTCTCTGGAACAACCCCTGGAAAAAGGCCAGGGGTAAAGACTCCTGTGTCTTCAACAGCAGTCTCATCTACAGTGAAGAAGGGGACTAAACAGACCACCCTTACTGAGATGTTCCCCAACATGGGCAGCTGAATGCTGTGTAAATTGGTTTTAGAAAACACTCTACAAACTTGAAGCAAACGTTAGGTGCTGCGCTGCTATTAAAGGACACTGTTTATCCACGTTCTGTTAActttttcagtttcttttcaTGTTTTTGCTAATACTCTTTCAGTGCCTTTCCTATGCTGTAAAGTCATGATTAAATAGTTTAGTTTCTTACAGCATTCCTGTAGTCATGACTTCGAGTTTGAAATGGTGTGAATGCTGCAGATGAAAATTATTCTGTGAGCATTTGCCTGTTCGAATAAAAGGAATGAGCGGTTTTCAGAATATTTGAGTTGTGTGGTTATTGGACAAATCAGAAAGACTGAAAGTAAGTTGGATGCACAGTCTGATATGTCTTATCTCGTTTGCTTCTGACCACATCATATCCATATTATATCACCCTGCAgaccaagaccggttactcactgaaggtaagcagggctgagcctggtcagtacttggatgggagaccacatgggaaaacatttgctgttggaaatggtgttacgggccgtttccactgagtggtacggtttggtatgcttttatgacgtttccactgtcaaaaggcgtaccaaaCTTCTTTTTGctcaccctttgcaaagggtaccaagggtaccaaaaggtggagctaaacgcccagctgaatgctattggtttacagagatacatcattcACTTGCGCAACaagccaaaatgaaaacaaaggaaccaccaTGTTTTAATTatacagccaagacattacaccataataattaggggtgtcacgatttcaatttttaatcaaaatcgatcaaaatttatgctcaatttcaattatcgaatccaaaaatagaatcgtcgatgctgccacgcccccatgtcacgtcagcttggcttgccaaacgggaaaaaaacaggcttgttgaagtgcttgttaaactgcagaagcaggagacccgtcgacagaacttaaaccctctcctctttcaatgatgtcgccggtgtgtaagcattttggatttccagtgagttgacaacgttcgtgttgtcgacaaaaaaaaaaaacacagttttgcaagctctgtttacactgtctttgtttttaaatggcattttagaacgacaacgatttgacatccaaagtggcgtgtagcatttctgagcagccctcctttctctctacctctgaaaatgcacatcacgtgaccacacagacgcactcacagccatgcgctcgagacagcaggtccaggcagtccagaagactgcttcaatctttcactcacttgtacttagtcattttagcgcacacctcagatactgttggctggttcctgttggttgtgcatctttttttatagacgccattataacgacacagatcactgcctattcacgagtcccgcagaaaaagtgattgacaggtggtaattatgtgtgtatcttgcctttattcatttactgtatgatttgtttatgggtaaaacaaagaccatgcaggtcaggtagtttaaacggtaggctacaaataattaattggtcattaattaattaattattcataattgaaaatcgaatcgaatagtgcctttagaatcgaaaatgtaatcgaatcgaggatttataggatcgtgacacccttaataataatatatacatataataacaagccatggtcgacccgagcttaaacaaaccttgttgttttCTTGATGGACATCTACGAAGCCAAGAAAAAGCAGATTCTACCCTCTGCCCTGTAGTTTTTTTATGAGCCCGTCTCAAGTGCGAGCTGTTTCGCTTTCTGTCTTGCGCTCTCGTCTATctacaaacttcttgagctgaagATAATAATGTGCGCTAGATTATTGACATGCTTTTGAcacccgatcctttcagaaacggacaaatgcgagagtgacgcgcaaaaaaaaacaaaggagcaaattattttttcagcaaacatgAGCAAACCGTTGTGTTTAACTATGGGGTATATTCCGAGCTAGtgtgtttcccatactgataaactgtGGTGACCTGTCATtgagtttttcatttttattttacacggttccttttacagcatttatgttgtaatgtaattcaaatacaatcagttaaacacactttggcattcatttagttgctcaagcgtaaaacgagacaaaaagccatttgctcgcacgcgcctgtcagaatcggcaggcttgcgcagaagctccattgaatatactggggtaaataaaaatgctcatatgataaagacatggcaggggaaaaGGTAATTTAATGCAGGGCTTCTTGTACAGTCTGAAATCCacttatatcggatatcactcagccagtggagatggctgatttttaaagaaaacagaccttaaacgtgcccATTGTGCATTGGCGTACAATTCACCAGaaacgattaacccaggttactggcaaattaaaagacctattagcatgcttcagcatataccctattatcaTCACCtcttggactattatgaactcggaatgatagaattactttctaacagaggtcacatgtgctgctgaagattaaagacacagataagaggtttgctctgactgtgggctatatttcgtgttgtttttgaacctaaataaggactaaatgtatgctgtgtgtagtttatctgtaattAGTAACAAATTGGAGACTTTaatggtctgtatgtgttcatatatgttgcatttatttatcctatataattgcagatgttatcatgtcattgatctgcagttacaaTCAAATTATGTTGAtggaaaagttagtaataaacatttatacagaagtatttatgtgtataaagcatctgttttgtgagaagtgcttctcatatgatatgtgaacgacctgtacagctttactgcagacattagcccctttcacacatacagacctttccggaaaattaccggcaattttccggaaaggttgtatgtgtgaacaggccctttttgaaaataccggtaaattcgttctggctattttccggaaagagaagttgtaacattaccggtaatttgccggaatgctgcgctgtgtgaatgcagaaggaagattgccgtaaacatcgcgtccacgtctagagcgtgctgacgtgagacacctgctttagccaatcagaacagtcagacgcattcacgtgcgcgcggtttatgagaataaaagcctttgaatatttttccagacacctttagctgctagatgttagtcagataacgtttctatgttccttcttaatgctaactgtgtaaataatcatcgataaaatgtttatgataatccgttgtttgtttaccttcaagctttgcgtgtgcccgtgagcgcccatagcgccagcacacacacatatcatgcacatctcgacatgcgaaagttttcattggagttgtactcaatactgatccatccaaagagtttgtaatgtagtcaaatgtttacaaacacaagcgcagccatttagaggtcatttctggttaatgatgtcagaatttactggcattttgcgatggatgtgtgaatgctcttttccggaaaaattccgtaacgtcctcgcctgtgagaacagcgcttttttgaatttaccggtaaagtcgttccgcaaattttccggatatttaccgctATCACTGTGTGAGGGGC
>TCONS_00017689
ATATCCATATTATATCACCCTGCAgaccaagaccggttactcactgaaggtaagcagggctgagcctggtcagtacttggatgggagaccacatgggaaaacatttgctgttggaaatg

Function


symbol description
rnf168 Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; ubiquitin binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including DNA metabolic process; histone H2A ubiquitination; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within DNA repair and chromatin organization. Predicted to be located in nucleus and site of double-strand break. Predicted to be part of ubiquitin ligase complex. Human ortholog(s) of this gene implicated in RIDDLE syndrome. Orthologous to human RNF168 (ring finger protein 168).

GO:

id name namespace
GO:0006302 double-strand break repair biological_process
GO:0006325 chromatin organization biological_process
GO:0045739 positive regulation of DNA repair biological_process
GO:0035518 histone H2A monoubiquitination biological_process
GO:0070535 histone H2A K63-linked ubiquitination biological_process
GO:0036351 histone H2A-K13 ubiquitination biological_process
GO:0036352 histone H2A-K15 ubiquitination biological_process
GO:0006974 cellular response to DNA damage stimulus biological_process
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter biological_process
GO:0045190 isotype switching biological_process
GO:0010212 response to ionizing radiation biological_process
GO:0016567 protein ubiquitination biological_process
GO:0033522 histone H2A ubiquitination biological_process
GO:0006511 ubiquitin-dependent protein catabolic process biological_process
GO:0006281 DNA repair biological_process
GO:0035861 site of double-strand break cellular_component
GO:0000151 ubiquitin ligase complex cellular_component
GO:0005634 nucleus cellular_component
GO:0042393 histone binding molecular_function
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding molecular_function
GO:0016740 transferase activity molecular_function
GO:0046872 metal ion binding molecular_function
GO:0004842 ubiquitin-protein transferase activity molecular_function
GO:0003682 chromatin binding molecular_function
GO:0043130 ubiquitin binding molecular_function

KEGG:

id description
ko04121 Ubiquitin system
ko03400 DNA repair and recombination proteins

ZFIN:

id description
ZDB-GENE-030131-6013 Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; ubiquitin binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including DNA metabolic process; histone H2A ubiquitination; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within DNA repair and chromatin organization. Predicted to be located in nucleus and site of double-strand break. Predicted to be part of ubiquitin ligase complex. Human ortholog(s) of this gene implicated in RIDDLE syndrome. Orthologous to human RNF168 (ring finger protein 168).

RNA


RNA id representative length rna type GC content exon number start site end site
TCONS_00017688 False 5619 mRNA 0.43 7 4101254 4124099
TCONS_00017689 True 119 rRNA 0.47 1 4104408 4104526

Neighbor


gene id symbol gene type direction distance location
XLOC_008967 si:dkey-83h2.3 coding downstream 6366 4085623 ~ 4094888 (-)
XLOC_008966 CR626884.2 coding downstream 34096 4062000 ~ 4067158 (-)
XLOC_008965 CR626884.5 coding downstream 48105 4049222 ~ 4053149 (-)
XLOC_008964 P2RY14 coding downstream 63628 4036709 ~ 4037626 (-)
XLOC_008963 CR626884.6 coding downstream 73887 4018362 ~ 4027367 (-)
XLOC_008969 ANO7 coding upstream 4461 4128560 ~ 4152582 (-)
XLOC_008970 NA coding upstream 39479 4163578 ~ 4174873 (-)
XLOC_008971 ece2b coding upstream 48189 4172288 ~ 4314097 (-)
XLOC_008972 atp1b3b coding upstream 229062 4353161 ~ 4415917 (-)
XLOC_008973 CU467614.1 coding upstream 241059 4365158 ~ 4365272 (-)
XLOC_008957 NA non-coding downstream 340297 3754566 ~ 3760957 (-)
XLOC_008952 NA non-coding downstream 938795 3160438 ~ 3162459 (-)
XLOC_008951 NA non-coding downstream 984992 3115337 ~ 3116262 (-)
XLOC_008946 CABZ01086029.1 non-coding downstream 1170233 2918257 ~ 2931021 (-)
XLOC_008942 NA non-coding downstream 1285112 2813516 ~ 2816142 (-)
XLOC_008997 FO704791.1 non-coding upstream 1258963 5383062 ~ 5383180 (-)
XLOC_009008 NA non-coding upstream 1774311 5898410 ~ 5901982 (-)
XLOC_009014 NA non-coding upstream 2844282 6968381 ~ 6976921 (-)

Expression



Co-expression Network