Bioproject ID: PRJNA369238

bioproject id PRJNA369238      to NCBI
key word Chemical; DNA METHYLATION; BPA EXPOSURE; LIFE STAGES; FISH; CHOLESTEROL; ATLANTIC; METABOLISM; DISRUPTS; IMPACTS; MEDAKA
experiment type chemical
publication Sadoul B et al., "Bisphenol A in eggs causes development-specific liver molecular reprogramming in two generations of rainbow trout.", Sci Rep, 2017 Oct 26;7(1):14131
description Multigenerational shifts in liver molecular programming in rainbow trout raised from bisphenol A-laden eggs
abstract Bisphenol A (BPA) is widely used in the manufacture of plastics and epoxy resins and is prevalent in the aquatic environment. BPA disrupts endocrine pathways in fish, but the long-term developmental implications are unknown. We demonstrate that BPA deposition in the eggs of rainbow trout(Oncorhynchus mykiss), an ecologically and economically important species of fish, reprograms liver metabolism in the offspring and alters the developmental growth trajectory in two generations. Specifically, BPA reduces growth during early development, followed by a catch-up growth post-juveniles. More importantly, we observed a developmental shift in the liver transcriptome, including an increased propensity for protein breakdown during early life stages to lipid and cholesterol synthesis post-juveniles. The liver molecular responses corresponded with the transient growth phenotypes observed in the F1 generation, and this was also evident in the F2 generation. Altogether, maternal and/or ancestral embryonic exposure to BPA affects livermetabolism leading to development-distinct effects on growth, underscoring the need for novel risk assessment strategies for this chemical in the aquatic environment. This is particularly applicable to migratory species, such as salmon, where distinct temporal changes in growth and physiology during development are critical for their spawning success.

Sample Information

sample id sample name tissue strain treatment description
1. SRR5217794 GSM2472231 liver nan Control nan
2. SRR5217822 GSM2472259 liver nan 4 ng BPA nan
3. SRR5217831 GSM2472268 liver nan Control nan
4. SRR5217837 GSM2472274 liver nan 4 ng BPA nan
5. SRR5217800 GSM2472237 liver nan 4 ng BPA nan
6. SRR5217811 GSM2472248 liver nan 4 ng BPA nan
7. SRR5217827 GSM2472264 liver nan 40 ng BPA nan
8. SRR5217795 GSM2472232 liver nan Control nan
9. SRR5217797 GSM2472234 liver nan Control nan
10. SRR5217799 GSM2472236 liver nan 4 ng BPA nan
11. SRR5217801 GSM2472238 liver nan 4 ng BPA nan
12. SRR5217802 GSM2472239 liver nan 40 ng BPA nan
13. SRR5217803 GSM2472240 liver nan 40 ng BPA nan
14. SRR5217804 GSM2472241 liver nan 40 ng BPA nan
15. SRR5217805 GSM2472242 liver nan 40 ng BPA nan
16. SRR5217806 GSM2472243 liver nan Control nan
17. SRR5217807 GSM2472244 liver nan Control nan
18. SRR5217810 GSM2472247 liver nan 4 ng BPA nan
19. SRR5217813 GSM2472250 liver nan 4 ng BPA nan
20. SRR5217814 GSM2472251 liver nan 40 ng BPA nan
21. SRR5217815 GSM2472252 liver nan 40 ng BPA nan
22. SRR5217816 GSM2472253 liver nan 40 ng BPA nan
23. SRR5217819 GSM2472256 liver nan Control nan
24. SRR5217821 GSM2472258 liver nan Control nan
25. SRR5217823 GSM2472260 liver nan 4 ng BPA nan
26. SRR5217824 GSM2472261 liver nan 4 ng BPA nan
27. SRR5217825 GSM2472262 liver nan 4 ng BPA nan
28. SRR5217828 GSM2472265 liver nan 40 ng BPA nan
29. SRR5217830 GSM2472267 liver nan Control nan
30. SRR5217833 GSM2472270 liver nan Control nan
31. SRR5217834 GSM2472271 liver nan 4 ng BPA nan
32. SRR5217835 GSM2472272 liver nan 4 ng BPA nan
33. SRR5217826 GSM2472263 liver nan 40 ng BPA nan
34. SRR5217796 GSM2472233 liver nan Control nan
35. SRR5217818 GSM2472255 liver nan Control nan
36. SRR5217829 GSM2472266 liver nan 40 ng BPA nan
37. SRR5217836 GSM2472273 liver nan 4 ng BPA nan
38. SRR5217839 GSM2472276 liver nan 40 ng BPA nan
39. SRR5217832 GSM2472269 liver nan Control nan
40. SRR5217820 GSM2472257 liver nan Control nan
41. SRR5217809 GSM2472246 liver nan Control nan
42. SRR5217812 GSM2472249 liver nan 4 ng BPA nan
43. SRR5217817 GSM2472254 liver nan 40 ng BPA nan
44. SRR5217798 GSM2472235 liver nan 4 ng BPA nan
45. SRR5217838 GSM2472275 liver nan 40 ng BPA nan
46. SRR5217840 GSM2472277 liver nan 40 ng BPA nan
47. SRR5217808 GSM2472245 liver nan Control nan
48. SRR5217841 GSM2472278 liver nan 40 ng BPA nan