CI01000063_00985283_00999270 (PTENB, PTEN)


Basic Information

Item Value
gene id CI01000063_00985283_00999270
gene name PTENB, PTEN
gene type coding
species grasscarp (Ctenopharyngodon idella)
category of species economic fish

Chromosome Information

Item Value
chromosome id CI01000063
NCBI id null
chromosome length 7808773
location 984521 ~ 999270 (-)
genome version v1_2015/06_NatureGenetics_grasscarp_Genome

Sequence

>CI01000063_00985283_00999270.mRNA
ATGGGCTTTCCTGCTGAAAGACTTGAGGGTGTCTACAGAAACAACATAGACGATGTTGTTCGATGTGCAGAAAGACATTATGATACTGCCAAATTTAACTGCAGAGTTGCACAGTATCCGTTTGAAGACCACAATCCTCCTCAGCTAGAGCTTATTAAGCCTTTCTGTGAAGATTTGGATAAGTGGCTCAGTGAAAATGACAATCATGTGGCTGCCATTCACTGCAAAGCTGGAAAGGGACGTACGGGTGTCATGATTTGTGCGTACTTATTACACCGAGGCAAATTCAAAAAAGCACAAGAGGCTCTGGACTTCTATGGTGAAGTTAGAACCAGAGACAAGAAGGGAGTGACTATTCCCAGTCAGAGGCGATATGTGTACTACTATAGCTACCTTCTGAAGAATAAGCTGGAGTACAAACCTGTGGCCTTGCTCTTTCACAAGATGGTGTTTGAGACAGTGCCTATGTTCAGTGGAGGTACCTGCAAACTGTCTCTGAAAAGTGCCATACAGTGCCATACAGAAACATACATATTAAACATCTGTGGCATGGGAGTGAATAAATTGGTTTACCAGATACCAAAGTATAAAATAAAGGGCTCAGGCAGATCAGATTGGTTGGATGTTGAAAAGAAGAGCTGGAATGGCAATTACACATTGTTTTATTTCACAGATCCTCAGTTTGTTGTGTACCAGCTGAAGGTGAAAATCCACACCTCCAACCCAGCGAACACAAGGCGAGAGGAGAAATACATGTACTTTGAGTTTCCGCAGCCGCTGCCTGTGTGTGGAGACATCAAGGTGGAGTTCTTCCACAAGCAGAACAAGATGATGAAAAAGGACAAGATGTTTCACTTCTGGGTGAACACCTTCTTCATCCCTGGACCAGAAGAGAGCTCAGAGAAGGTTGAAAACGGAGGTTTAGTGAAGGAACTGGATGGAATCCAAGCCCCAGAACGGGTAGAGAATGACAAGGATTATCTAATCCTGACTTTAACCAAGAACGACTTGGATAAAGCCAATAAGGATAAAGCCAACCGATACTTCTCTCCAAACTTCAAGGTGAAGCTGTACTTCACAAAAACAGTGGAAGAACCATCCAACTCGGAGGCCAGCACTTCTACATCTGTAACCCCGGATGTTAGCGATAATGAACCGGACCATTACCGGTATTCGGACACAACAGACTCGGACCCTGAAAATGAACAGTATGATGAAGAACAGATTACTAAAGTTTGAAATATTTTTATGGGAAGAAAAAAAAGAAACCATACGTAATAGAGTTGTATAAAGGAGAAAACTTGAATATGAACTGAAAGCAAGTACTCCCCCCCCCCCCCCCCCCCCTCAAGCAGAAGTAGGACACGTCACACAAAACGCCACCAGTTTTAGGGACAAAAATGCTGACCAATTTTTTTGTTCATTTGCCCCTCTCCATGAAGTATCAACACTGATGTTCCGTGGAAAACGGCATCAGTAGCTATTATGTAAATACATGTTCATGCCGTAACACAAGAAAGGAAACCCAGTCAGGATGGGAGATTGTGAGATTGTTTATGGGAGAAATCCAGTGGAGATCGAAATTTGCTGCTCCATCAACCTGTTGACACCAAGGCCAGTGCTTTAATCAGCATTCATGCCCCCATGTCTGTCCTTCTTTAGTCTGTCCTACCTACTGTGAAACTGTTCTCATGCTGCTGGAAGGCCGCCACGTGTCAGTCGGGCTCTGTTGTGCAGTGGAATTTTTCAGTCTGCTTTCATCATTATTACCACTACTAAAGTGGAGGTGGTAATGATTCTTTTAAACTACATGACACCTTGGCAGTAAACACAACAAATAACTCCATGTATTATTATTATTATTATTATTATTATATATTTTTTTCCTCTTTTTTTTTTTTTAATGCAAACACACACAACACAACAGGGAAACCAGTGTTGCAATAATGTTGATCGAAGGTGTGCATGTTATTGGAATCAGTTTCCATGTTGTAAAATAAA

Function

symbol description
ptenb Enables lipid phosphatase activity. Acts upstream of or within several processes, including lifelong otolith mineralization; negative regulation of angiogenesis; and phosphatidylinositol dephosphorylation. Predicted to be located in PML body and cytoplasm. Predicted to be active in several cellular components, including cytosol; nucleus; and plasma membrane. Is expressed in several structures, including adaxial cell; blastomere; nervous system; neural rod; and pectoral fin. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; breast cancer (multiple); gastrointestinal system cancer (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog).
pten Enables several functions, including PDZ domain binding activity; anaphase-promoting complex binding activity; and phosphatase activity. Involved in several processes, including dephosphorylation; negative regulation of cell migration; and regulation of cellular protein metabolic process. Acts upstream of or within negative regulation of protein kinase B signaling. Located in several cellular components, including apical plasma membrane; cytoplasmic side of plasma membrane; and nucleoplasm. Implicated in several diseases, including Cowden syndrome; PTEN hamartoma tumor syndrome; breast cancer (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Biomarker of several diseases, including PTEN hamartoma tumor syndrome; gastrointestinal system cancer (multiple); in situ carcinoma (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple).

GO:

id name namespace
GO:0016791 phosphatase activity molecular_function

KEGG:

id description
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

RNA

RNA id representative length rna type GC content exon number start site end site
CI01000063_00985283_00999270.mRNA True 2001 mRNA 0.42 9 984521 999270

Neighbor

gene id symbol gene type direction distance location
CI01000063_00864936_00881531 LIPA, LIPF coding downstream 102990 864319 ~ 881531 (-)
CI01000063_00846790_00858096 STAMBPL1 coding downstream 125143 846622 ~ 859378 (-)
CI01000063_00808299_00809636 NA coding downstream 174885 808060 ~ 809636 (-)
CI01000063_00805911_00806593 NA coding downstream 177889 805911 ~ 806632 (-)
CI01000063_00792983_00795702 NA coding downstream 185307 792436 ~ 799214 (-)
CI01000063_01015926_01020021 PAPSS2A, PAPSS2B, PAPSS2, PAPS2 coding upstream 16656 1015926 ~ 1020021 (-)
CI01000063_01023917_01026650 MINPP1B coding upstream 24383 1023653 ~ 1027279 (-)
CI01000063_01029007_01032212 NA coding upstream 29712 1028982 ~ 1032212 (-)
CI01000063_01070457_01077403 USP42 coding upstream 70953 1070223 ~ 1077862 (-)
CI01000063_01079985_01087813 EIF2AK1 coding upstream 80252 1079522 ~ 1087813 (-)
G262876 NA non-coding downstream 12740 956722 ~ 971781 (-)
G262970 NA non-coding downstream 31142 953157 ~ 953379 (-)
G262967 NA non-coding downstream 33992 950177 ~ 950529 (-)
G262965 NA non-coding downstream 35520 948588 ~ 949001 (-)
G262964 NA non-coding downstream 36307 947952 ~ 948214 (-)
G262985 NA non-coding upstream 94362 1093632 ~ 1094713 (-)
G262988 NA non-coding upstream 96077 1095347 ~ 1095623 (-)
G262990 NA non-coding upstream 98170 1097440 ~ 1098132 (-)
G262999 NA non-coding upstream 150342 1149612 ~ 1149869 (-)
G263002 NA non-coding upstream 153619 1152889 ~ 1153127 (-)
CI01000063_01669384_01670016 HBAE1 other upstream 670141 1669317 ~ 1672019 (-)
CI01000063_02177769_02178239 NA other upstream 1177169 2177747 ~ 2178395 (-)
CI01000063_02326799_02327290 CBY1 other upstream 1325842 2326741 ~ 2327309 (-)
CI01000063_02725759_02726399 NA other upstream 1726489 2725759 ~ 2726535 (-)
G265567 NA other upstream 4163224 5183279 ~ 5183287 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
bowfin (Amia calva) AMCG00002922 pten,LOC104929647 coding CM030139.1 CM030139.1 6297737 ~ 6319780 (-)