XLOC_010417 (ctnnb1)


Basic Information

Item Value
gene id XLOC_010417
gene name ctnnb1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007127.7
NCBI id CM002900.2
chromosome length 55266484
location 6182501 ~ 6205790 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00020474
GTGCTGCTGCTGCGCGAGCGCGGAGTTCTCGCGCACACATTCACTCTCAGCAGGAGCTGCCGCGCGCTGCGGGTTGTTCTCTCACATTTTCTCAACGGATTGTCGCCATTATTCGCGTTTTACGTGCTGAAAACCGAAACAGGAATATACAGCTTTTGACACAGattaGTAAGCTGTGCCCGGCTGTGAGAAAATCATGGCTACCCAGTCTGACTTGATGGAGCTGGAAATGGCCATGGATCCGGATCGCAAGGCTGCAGTCAGCCATTGGCAGCAACAGTCTTACCTGGACTCAGGAATCCACTCTGGGGCCACAACTACTGCCCCGTCCCTGAGTGGCAAAGGCAACCCGGAGGATGACGATGTGGATAATCAGGTGCTTTATGAGTGGGAGCAGGGCTTCAACCAGTCCTTCAACCAAGAGCAAGTAGCAGACATCGATGGTCAATACGCCATGACCAGAGCCCAGAGAGTCCGGGCGGCCATGTTCCCGGAGACTCTCGATGAGGGCATGCAGATACCTTCCACACAGTTCGACTCTGCGCATCCCACCAATGTCCAGCGCCTGGCTGAGCCCTCGCAGATGCTCAAACATGCCGTGGTCAACCTCATCAACTACCAGGACGACGCAGAGCTGGCCACTCGTGCCATTCCAGAGCTCACCAAACTACTGAACGACGAGGATCAGGTGGTGGTTAATAAGGCAGCTGTGATGGTGCACCAGCTCTCCAAGAAAGAGGCCTCTCGTCACGCCATCATGCGCTCCCCACAGATGGTATCGGCCATTGTGAGGACCATGCAGAACACTAATGATGTAGAAACAGCCCGTTGCACCTCTGGCACCCTACACAATCTTTCCCACCACAGAGAAGGACTGCTTGCCATCTTTAAATCAGGAGGCATCCCTGCCCTCGTCAAAATGCTCGGCTCCCCTGTGGACTCTGTGCTGTTTTACGCTATTACGACTCTACACAACCTGCTACTGCACCAAGAAGGAGCCAAGATGGCTGTTCGACTGGCCGGAGGCCTGCAGAAAATGGTGGCcttgttaaacaaaacaaacgtCAAATTCCTCGCCATCACGACAGACTGCCTTCAGATTCTGGCATACGGCAATCAGGAAAGCAAACTTATCATTCTGGCCAGCGGAGGCCCACAGGCTTTGGTCAACATCATGAGGACATACACCTATGAGAAGCTGTTATGGACGACCAGTCGAGTGCTCAAGGTGTTGTCAGTGTGCTCCAGTAACAAACCTGCCATTGTGGAGGCTGGTGGCATGCAAGCCCTCGGCCTTCATCTCACAGACCCCAGCCAGCGACTGGTACAGAACTGCTTGTGGACTTTGAGGAATCTGTCAGACGCCGCCACCAAACAGGAGGGCATGGAGGGGCTCTTGGGCACCCTGGTGCAGTTGCTCGGGTCAGATGACATCAACGTGGTGACGTGTGCTGCTGGAATCCTGTCCAACCTGACCTGCAACAACTACAAAAACAAGATGATGGTGTGCCAAGTGGGTGGCATCGAGGCCCTCGTGCGCACCGTTCTTCGTGCCGGAGACAGAGAGGATATCACAGAGCCGGCTATCTGCGCTCTCCGTCACCTCACATCCAGACACCAGGATGCAGAGATGGCCCAGAATGCAGTGCGGCTGCACTATGGACTGCCTGTAGTAGTCAAACTGCTCCACCCTCCTTCACATTGGCCTCTCATTAAGGCTACAGTCGGGCTGATCCGCAACCTGGCACTGTGCCCCGCCAACCATGCCCCGCTCCGAGAGCAGGGTGCCATTCCCCGCCTGGTGCAGCTTCTAGTCCGGGCCCATCAGGACACTCAGAGACGCACCTCCATGGGTGGAACACAGCAGCAGTTTGTGGAGGGTGTGCGTATGGAGGAGATTGTGGAGGGCTGCACTGGAGCTCTGCACATTCTAGCCAGAGACATTCACAACAGAATCGTCATCAGAGGACTCAACACTATTCCACTCTTTGTTCAGtTGCTGTATTCTCCTATCGAGAACATCCAGCGTGTGGCTGCAGGAGTGCTGTGTGAACTGGCTCAGGATAAGGAGGCGGCAGAAGCCATCGAGGCAGAAGGAGCCACTGCTCCACTCACAGAGCTCCTGCACTCCAGAAACGAGGGAGTCGCCACGTACGCTGCTGCAGTTCTGTTCCGCATGTCTGAGGATAAGCCCCAGGACTACAAGAAGCGACTGTCTGTGGAGCTCACCAGCTCTCTGTTCAGAACTGAGCCCATGACCTGGAACGAGACTGGAGATCTAGGGCTGGATATCGGTGCACAGGGAGAGCCTCTGGGCTACAGACAGGACGACCCAAGCTACCGCTCCTTCCATTCCGGAGGTTATGGGCAGGACGCCATGGGAATGGACCCCATGATGGAGCACGAGATGGCCGGGCACCACCCGGGCCCTGATTACCCCGTAGACGGCCTGCCTGACCTCGGCCACACCCAGGACCTGATCGACGGCCTCCCGCCAGGCGACAGCAATCAGCTGGCCTGGTTTGACACCGATCTGTAAATACAATGACTTTTTAGCTGTATCGTCTGATCTGAATGAACCTGCATTGTGATTTTGGCCTGTAGAGTTGCTGAGCGGGCTCAAGAGAGAGTGGGCTAGTTTCTCTGAAAGTGCCTGACACACTAATACAAGCTGAGTTTCCTATGGGAACACGTGGAAGTAAAACGTTTGGTTCTGATCCTAGCCGGTCAGAATTTTTGGTGTGATTGACAGAAgaaagcccaaaaaaaaaaagaagcaaatcCTAAGATGGAGTTTTCAACCTTAGCCTTGcctgtacttttattttattttttcttactttttatttttcaaaggATATCTGGGTCTGTAATGGTACTTATCTAGCTTGCTTTATGATACTCGTCTTTTTATTTTGCAGAACTTTGTATTCCTTTCgactgtctctctttctctctcatagtGTTGAGTTCTAGTGGTAATGATCCATCAAGATTTTATCGACTTTATGGTGTAGAACACTAATTAATCAGTTGAATTGTATTCTTATCAAATGTAACATTGTGTAGCTTTTGTATAAAACCAAGAATTGGAGAAGTCCAAATATCAGCTCTCTTGCTTTAATGAAATCACAAATGTTCCAAAGGGTTTGCAATCAGTTGGGGCcagttttgctttcattttttttttacttttcagttCTCGTTTGATTTTACTTTACTGTCTTGatctattatgattattttttttgatgGTAGCTTTAGAAAGGTTTTTGAAAAGAACCCCTAATTATTGTAGCCTGCGATTTGTTGGTTGGAGACTTGGCTAAATAAAATGGACTTTAAATTT
>TCONS_00021780
TCTTTGTTCAGtTGCTGTATTCTCCTATCGAGAACATCCAGCGTGTGGCTGCAGGAGTGCTGTGTGAACTGGCTCAGGATAAGGAGGCGGCAGAAGCCATCGAGGCAGAAGGAGCCACTGCTCCACTCACAGAGCTCCTGCACTCCAGAAACGAGGGAGTCGCCACGTACGCTGCTGCAGTTCTGTTCCGCATGTCTGAGGATAAGCCCCAGGACTACAAGAAGCGACTGTCTGTGGAGCTCACCAGCTCTCTGTTCAGAACTGAGCCCATGACCTGGAACGAGACTGGAGATCTAGGGCTGGATATCGGTGCACAGGGAGAGCCTCTGGGCTACAGACAGGACGACCCAAGCTACCGCTCCTTCCATTCCGGAGGTTATGGGCAGGACGCCATGGGAATGGACCCCATGATGGAGCACGAGATGGCCGGGCACCACCCGGGCCCTGATTACCCCGTAGACGGCCTGCCTGACCTCGGCCACACCCAGGACCTGATCGACGGCCTCCCGCCAGGCGACAGCAATCAGCTGGCCTGGTTTGACACCGATCTGTAAATACAATGACTTTTTAGGTGAGGCACGCCAATGGTTGCTTTGATCTGTGCGCACCGTGTGTGGGAGAGTAGAGTGTAAAGCAGCACGCACCCAGTAGCAGAACTAATCTGAGCTGCTTCTCAATTCATTACacgagcgagtgtgtgtgtgtgtttaatgggATTCTAATCTGTTGTTTGtcccccccctctctctttctctgctgcAGCTGTATCGTCTGATCTGAATGAACCTGCATTGTGATTTTGGCCTGTAGAGTTGCTGAGCGGGCTCAAGAGAGAGTGGGCTAGTTTCTCTGAAAGTGCCTGACACACTAATACAAGCTGA
>TCONS_00020475
attaGTAAGCTGTGCCCGGCTGTGAGAAAATCATGGCTACCCAGTCTGACTTGATGGAGCTGGAAATGGCCATGGATCCGGATCGCAAGGCTGCAGTCAGCCATTGGCAGCAACAGTCTTACCTGGACTCAGGAATCCACTCTGGGGCCACAACTACTGCCCCGTCCCTGAGTGGCAAAGGCAACCCGGAGGATGACGATGTGGATAATCAGGTGCTTTATGAGTGGGAGCAGGGCTTCAACCAGTCCTTCAACCAAGAGCAAGTAGCAGACATCGATGGTCAATACGCCATGACCAGAGCCCAGAGAGTCCGGGCGGCCATGTTCCCGGAGACTCTCGATGAGGGCATGCAGATACCTTCCACACAGTTCGACTCTGCGCATCCCACCAATGTCCAGCGCCTGGCTGAGCCCTCGCAGATGCTCAAACATGCCGTGGTCAACCTCATCAACTACCAGGACGACGCAGAGCTGGCCACTCGTGCCATTCCAGAGCTCACCAAACTACTGAACGACGAGGATCAGGTGGTGGTTAATAAGGCAGCTGTGATGGTGCACCAGCTCTCCAAGAAAGAGGCCTCTCGTCACGCCATCATGCGCTCCCCACAGATGGTATCGGCCATTGTGAGGACCATGCAGAACACTAATGATGTAGAAACAGCCCGTTGCACCTCTGGCACCCTACACAATCTTTCCCACCACAGAGAAGGACTGCTTGCCATCTTTAAATCAGGAGGCATCCCTGCCCTCGTCAAAATGCTCGGCTCCCCTGTGGACTCTGTGCTGTTTTACGCTATTACGACTCTACACAACCTGCTACTGCACCAAGAAGGAGCCAAGATGGCTGTTCGACTGGCCGGAGGCCTGCAGAAAATGGTGGCcttgttaaacaaaacaaacgtCAAATTCCTCGCCATCACGACAGACTGCCTTCAGATTCTGGCATACGGCAATCAGGAAAGCAAACTTATCATTCTGGCCAGCGGAGGCCCACAGGCTTTGGTCAACATCATGAGGACATACACCTATGAGAAGCTGTTATGGACGACCAGTCGAGTGCTCAAGGTGTTGTCAGTGTGCTCCAGTAACAAACCTGCCATTGTGGAGGCTGGTGGCATGCAAGCCCTCGGCCTTCATCTCACAGACCCCAGCCAGCGACTGGTACAGAACTGCTTGTGGACTTTGAGGAATCTGTCAGACGCCGCCACCAAACAGACGTCTTTAGCAGAAGTAGATGTGCAGGAGGGCATGGAGGGGCTCTTGGGCACCCTGGTGCAGTTGCTCGGGTCAGATGACATCAACGTGGTGACGTGTGCTGCTGGAATCCTGTCCAACCTGACCTGCAACAACTACAAAAACAAGATGATGGTGTGCCAAGTGGGTGGCATCGAGGCCCTCGTGCGCACCGTTCTTCGTGCCGGAGACAGAGAGGATATCACAGAGCCGGCTATCTGCGCTCTCCGTCACCTCACATCCAGACACCAGGATGCAGAGATGGCCCAGAATGCAGTGCGGCTGCACTATGGACTGCCTGTAGTAGTCAAACTGCTCCACCCTCCTTCACATTGGCCTCTCATTAAGGCTACAGTCGGGCTGATCCGCAACCTGGCACTGTGCCCCGCCAACCATGCCCCGCTCCGAGAGCAGGGTGCCATTCCCCGCCTGGTGCAGCTTCTAGTCCGGGCCCATCAGGACACTCAGAGACGCACCTCCATGGGTGGAACACAGCAGCAGTTTGTGGAGGGTGTGCGTATGGAGGAGATTGTGGAGGGCTGCACTGGAGCTCTGCACATTCTAGCCAGAGACATTCACAACAGAATCGTCATCAGAGGACTCAACACTATTCCACTCTTTGTTCAGtTGCTGTATTCTCCTATCGAGAACATCCAGCGTGTGGCTGCAGGAGTGCTGTGTGAACTGGCTCAGGATAAGGAGGCGGCAGAAGCCATCGAGGCAGAAGGAGCCACTGCTCCACTCACAGAGCTCCTGCACTCCAGAAACGAGGGAGTCGCCACGTACGCTGCTGCAGTTCTGTTCCGCATGTCTGAGGATAAGCCCCAGGACTACAAGAAGCGACTGTCTGTGGAGCTCACCAGCTCTCTGTTCAGAACTGAGCCCATGACCTGGAACGAGACTGGAGATCTAGGGCTGGATATCGGTGCACAGGGAGAGCCTCTGGGCTACAGACAGGACGACCCAAGCTACCGCTCCTTCCATTCCGGAGGTTATGGGCAGGACGCCATGGGAATGGACCCCATGATGGAGCACGAGATGGCCGGGCACCACCCGGGCCCTGATTACCCCGTAGACGGCCTGCCTGACCTCGGCCACACCCAGGACCTGATCGACGGCCTCCCGCCAGGCGACAGCAATCAGCTGGCCTGGTTTGACACCGATCTGTAAATACAATGACTTTTTAG

Function

symbol description
ctnnb1 Enables cadherin binding activity. Involved in positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification. Acts upstream of or within several processes, including determination of dorsal/ventral asymmetry; ectoderm development; and glomerular filtration. Located in several cellular components, including intercalated disc; microvillus; and zonula adherens. Part of catenin complex. Is expressed in several structures, including EVL; adaxial cell; brain; germ ring; and gonad. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant non-syndromic intellectual disability 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Orthologous to human CTNNB1 (catenin beta 1).

GO:

id name namespace
GO:0003094 glomerular filtration biological_process
GO:0048262 determination of dorsal/ventral asymmetry biological_process
GO:0009953 dorsal/ventral pattern formation biological_process
GO:2000055 positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification biological_process
GO:0001889 liver development biological_process
GO:0000578 embryonic axis specification biological_process
GO:0007398 ectoderm development biological_process
GO:0045944 positive regulation of transcription by RNA polymerase II biological_process
GO:0060026 convergent extension biological_process
GO:0007155 cell adhesion biological_process
GO:0016055 Wnt signaling pathway biological_process
GO:0005886 plasma membrane cellular_component
GO:0005902 microvillus cellular_component
GO:0005912 adherens junction cellular_component
GO:0005915 zonula adherens cellular_component
GO:0005634 nucleus cellular_component
GO:0005938 cell cortex cellular_component
GO:0014704 intercalated disc cellular_component
GO:0016020 membrane cellular_component
GO:0016342 catenin complex cellular_component
GO:0005737 cytoplasm cellular_component
GO:0035257 nuclear hormone receptor binding molecular_function
GO:0005515 protein binding molecular_function
GO:0003713 transcription coactivator activity molecular_function
GO:0019903 protein phosphatase binding molecular_function
GO:0045294 alpha-catenin binding molecular_function
GO:0045296 cadherin binding molecular_function

KEGG:

id description
ko04015 Rap1 signaling pathway
ko04310 Wnt signaling pathway
ko04390 Hippo signaling pathway
ko04510 Focal adhesion
ko04520 Adherens junction
ko04550 Signaling pathways regulating pluripotency of stem cells
ko04670 Leukocyte transendothelial migration
ko04919 Thyroid hormone signaling pathway
ko04916 Melanogenesis
ko05200 Pathways in cancer
ko05205 Proteoglycans in cancer
ko05210 Colorectal cancer
ko05225 Hepatocellular carcinoma
ko05226 Gastric cancer
ko05216 Thyroid cancer
ko05217 Basal cell carcinoma
ko05215 Prostate cancer
ko05213 Endometrial cancer
ko05224 Breast cancer
ko05160 Hepatitis C
ko05163 Human cytomegalovirus infection
ko05167 Kaposi sarcoma-associated herpesvirus infection
ko05165 Human papillomavirus infection
ko05132 Salmonella infection
ko05100 Bacterial invasion of epithelial cells
ko05010 Alzheimer disease
ko05022 Pathways of neurodegeneration - multiple diseases
ko05418 Fluid shear stress and atherosclerosis
ko05412 Arrhythmogenic right ventricular cardiomyopathy
ko04934 Cushing syndrome

ZFIN:

id description
ZDB-GENE-980526-362 Enables cadherin binding activity. Involved in positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification. Acts upstream of or within several processes, including determination of dorsal/ventral asymmetry; ectoderm development; and glomerular filtration. Located in several cellular components, including intercalated disc; microvillus; and zonula adherens. Part of catenin complex. Is expressed in several structures, including EVL; adaxial cell; brain; germ ring; and gonad. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant non-syndromic intellectual disability 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Orthologous to human CTNNB1 (catenin beta 1).

Ensembl:

ensembl_id ENSDARG00000014571

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00020474 False 3349 mRNA 0.51 16 6182501 6205790
TCONS_00021780 False 881 lncRNA 0.55 5 6183175 6188967
TCONS_00020475 True 2419 mRNA 0.56 15 6183485 6198543

Neighbor

gene id symbol gene type direction distance location
XLOC_010415 trak1a coding downstream 308635 5786770 ~ 5873866 (-)
XLOC_010416 BX957314.1 coding downstream 311812 5870573 ~ 5870689 (-)
XLOC_010414 NA coding downstream 396459 5746308 ~ 5786042 (-)
XLOC_010413 ndufa3 coding downstream 461115 5717760 ~ 5721386 (-)
XLOC_010412 si:dkey-283b15.2 coding downstream 510639 5650495 ~ 5671862 (-)
XLOC_010418 NA coding upstream 42233 6248023 ~ 6249246 (-)
XLOC_010419 NA coding upstream 85383 6291173 ~ 6351690 (-)
XLOC_010420 scgn coding upstream 150670 6356460 ~ 6377672 (-)
XLOC_010421 NA coding upstream 177740 6383530 ~ 6386642 (-)
XLOC_010422 ndufb9 coding upstream 181151 6386941 ~ 6391279 (-)
XLOC_010626 CR392024.2 misc upstream 14689322 20895112 ~ 20895175 (-)
XLOC_010411 NA non-coding downstream 538763 5636286 ~ 5643738 (-)
XLOC_010409 NA non-coding downstream 593881 5453180 ~ 5588620 (-)
XLOC_010408 NA non-coding downstream 1009058 5169775 ~ 5173443 (-)
XLOC_010424 NA non-coding upstream 270226 6476016 ~ 6484227 (-)
XLOC_010425 NA non-coding upstream 306556 6512346 ~ 6556501 (-)

Expression


Co-expression Network