XLOC_010448 (ddc)


Basic Information

Item Value
gene id XLOC_010448
gene name ddc
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007127.7
NCBI id CM002900.2
chromosome length 55266484
location 8298542 ~ 8342749 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00020522
gtgtgtgtgtgtgtgtgtgtgtttgtatatgtgtgtttgaaaCCGGCAGAAAGCGTACGAGGATCAACAGGAGGGAGGACTCTTCTTTATTTGCCCGACACTACTAAAAGATGGATGCCGCAGAGTTTCGGAGACGCGGGAGGGAGATGGTTGATTATGTGGCGGATTATATAGAGAACATTGAGAAAAGGCAGGTTTACCCTGATGTGGAACCGGGATATCTGAGGTCACTGATTCCTGAGGAGGCCCCCGAGGAGCCAGAGAGCTATGAGGATGTGGTCAAAGACATCGAGAGGGTGATCATGCCAGGGGTCACCCACTGGCACAGCCCATACTTCTATGCATATTTTCCCACTGCCCACTCTTATCCTGCAATGCTCGCAGACATACTGTGTGGAGCCATTGGCTGCATTGGATTCTCTTGGGCTGCAAGTCCTGCCTGTACGGAGCTAGAGACAGTGATGCTGGACTGGCTGGGAAAGATGCTGAAGCTACCGGAAGATTTTCTTGCTGGGACCAAAGGCAAAGGAGGTGGGGTCATCCAGAGCACTGCCAGTGAAGCCACTCTCATAACCCTTCTTGCTGCTCGCTCCAAAATCGTCAGGCTGATCCAGGCGGACCATCCTGACCGATCTGAGACTGACATTATATCCAAACTAGTTGCCTATTCATCTGATCAGGCACACTCATCGGTGGAGAGGGCAGGGTTGATAGGTGGAGTGAGAATGAAGAAAATTCCTACCGACAGCAAGTTTTCTGTGCGAGGAGATGCACTGGAGAGGATCCTAAAGGAGGATAAAGCTGCTGGACTTATACCATTTTTTTTCTGTGCAACACTGGGAACAACTGCATCCTGTGCATTCGACTGCATCACTGAGCTGGGCCCTATATGCAATGCAGAGAAAATGTGGATGCACATCGATGCTGCATATGCCGGGAGTGCTTTTATCTGTCCGGAGTTCAGACCCTTGCTGAACGGCATTGAGTTTGCAGACTCTTTCAATTTCAATCCTCATAAATGGCTCCTGATCAACTTTGATTGCTCGGCGATGTGggTAAAGAAAAGAGCAGACATTATTGGAGCATTTAAAATGGAGCCACTTTATCTAAAGCATGATCACCAAGAGTCAGgacTTGTCACTGATTATAGACACTGGCAGATCCCGCTGGGTCGGAGGTTTCGCTCTCTCAAAATGTGGTTTGTGTTCCGCATGTACGGACTCAAAGCTCTCCAAGCCTACATCCGCAAGCATGTAGGACTGGCTAAAGAGTTCGAGGCTTTCGTGAGAGCTGATCAACGCTTTGAGATCTCAGCTGATGTGGTGATGGGTCTCGTCTGCTTTAGACTCAAGGGCCCCAATGAATTAAGTGAAAATCTGCTGAAGAGGATCAACAGCGCACGGAAGATTCATCTGGTTCCTTGCCACCTGGCTGGCCTGTTTGTTCTGCGGTTTGCCGTGTGTGCCCGCGCTACTGAGTCACGTCATGTCCAGGAGGCCTGGTGCCACATCCGTCAGCTGGCATCAGAGCTGCTTCAGGAACTGCTACACTGACCATTGCAGTGGGCATCACAAttgtacactctcaaaaataaaggtatgctagttgtcactagggtggtaacttttcaaaaggtacaaatttgtacctaaaaggacCATATTAATACTTATTATATAGTTCTGAGGTACTAATATGGatccttcaagtacaaatgtgtacaaaaaggtaccaccccagtgacagctctcatacctttatttGTGAGAGTGTACCACATCTGCTTTCACACTGTCTTAATTCCCCTCTATCGCTGATTCATGCTATTTATTGGCAAAATATGTGTATCTGTGCGTCCGTGATTGTCATAATGGTGTCTGCCATGAGTGTGTAGCAATCCAGGCTCTGGAATATATCCTCTGCCTACATTTAATGACATGATGTCCAAAAAAGGCACATCATATCATGTTTGTCGATTGCAGATTTCTTTTTCACGATATTCCTCCTCACCCCGGTAATCATTATAGACCTGCAAGAAAGATTATTATAATAATCAATTAACCAACAACTAATCGCTAAATATTTCAATAACTAATCAGTAGGTTTTTAATGATTGTTCAACTTTTGTGACGAGTTGAAACAGTTGTAGATCctaagtaatcatttaaaaaataatgcaattgTCAGCTTTTGAAATGTTCTAATGCACTTGAGATGTTTTAATGAACTTTGATCAAACTGAACAGATCACTCTCTTTCAGTTTTCTGATTTTGTCATTGAATCATTTTCACttcaaaccaaaaataaaaatataatgttgtaAACAAATCTCTTCACGACAGAATCTCTGTCAAcagtttgatttaattaaaaaaaagggaCAGAAAAAGGGCATTTTACTTCAGGACAGCCACAATGGCAAAGTATTAACCGGTAAACAATTATTAGAAAAATTATTGTACAAATAAAAAGACAAGCAGCGGCTTTCTCATAAGTAACTGATATGATTTTTTCCCCAACATGTCTGTTTTTAAGCTTTTAcaaatatggaaaaaaattaaGTCATAATACTCATAtcggcgacgcggtggcgcagtaggtagtgctgtcgcctcacagcaagaaggtcgctggttcgagcctcggctgggtcagttagcatttctctgtggagtttgcatgttctccccgtgtttgcatgggttttctccgggtgctccggtttccccccacagtccaaagacatgtggtacaggtgaattgggtaagctaaaattgtccatagtgtatgtgtgtgaatgagagtgtatggatgtttcccagtactgggttgaagctggaagggcatccgctgcgtaaaacacatgccaaAATAGTtagctgttcattctgctgtggaaggaaaatgaatgaattaattacttaatttcattagtttgtttaaattcagggcgaagcagtggcgcagtaggtagtgttgtcgcctcacagcaagaaggtcactgggttgctggttcgagcctcggctcagttggcgtttctgtgtggagtttgtatgttctccctgtgttcgcgtgggtttcctccgggtgctccggtttcccccatagtccaaagacatgtggtacaggtgaattgggtaggctaaattgtccgtagtgtatgggtgtcggtgtgattgtgtgtgtgatttttcccagagatgggttgcggctggaagggcattcgctgcgtaaaaatgtgctggataagttgacggttcattccgctgtggcgaccccggattaataaagggactaagctgacacgaaaatgaatgaatgaatgtttaaattcagcccataaaaatagtttgcaaccatttacattttaaaaatgaagtaaattcaataaaatgaatcattttttcagtgtggaCAGCTTGCTAAGTTTTAAATACACTTAGATCAGTCGGATGAGAAGTTTAAAAAATCAAAGTAAGGGATTTAtcaaccaacaaaacaaaacaaaacaaaaaaaatcagtccCTCCAATAGACAAGAATATtagtcaacaattttttttaagagtCGACATTGGCGACTAATTGTTGCAGCCCTTGTAATCATCAAACTGTCAAATAAGAACAAAAGAAGCATTCACTTGTACTAGAAACTGCAGTATGTAGGCCGTCACATATTTCTACTGagtgtgtctctgtgtttgtgaGCTTTTATGCTTATATCATGTGTCCTCCAGCTGTAAGCACTTTGTCCAAAAATGTACCGTCGTGCACTTGAAAATGAgtctattataaaataaaaagttttttaccTATTTAGAGAATGATTTATCTTTAAAATGGCTACAGAGAATATTTTGTTGATTGATTTATAGAAACATTagcctttattgttttttttttctctccactgTCGCtcaatgaaatgaaatattgagCCTAATCAGAGTCTAATTCCTTTCATTTCCTAAAAAATATTGTTCCTGATTCAGCAAGGCTCACGTAGTTATTGTTATTGTGCCTGATAAGTTAAAAAGATCTGACTCTGGGacatattaaaacaatttttgtgTACTGTGTGTTAACGTTCACAATAAAGTGCATTTCTCCCAAAA
>TCONS_00020523
aaaaaaaacagaaatacacTGAAAACGTGAACTAAATTatagtcaagtttttttttaaacgctAAAAAGGATGAAAAAACCCCACCTGCTATATTGTAttgtaatttataaataatttttacaacTGACAATGCTATAAATGCATATTTGCTTGGCTAATGTTAATTTGAATGATTTTCAAATGATCTGCATATATCCTGTTTGCAATGTATTGTCGATCGTGTTTCAGCATGTAGGACTGGCTAAAGAGTTCGAGGCTTTCGTGAGAGCTGATCAACGCTTTGAGATCTCAGCTGATGTGGTGATGGGTCTCGTCTGCTTTAGACTCAAGGGCCCCAATGAATTAAGTGAAAATCTGCTGAAGAGGATCAACAGCGCACGGAAGATTCATCTGGTTCCTTGCCACCTGGCTGGCCTGTTTGTTCTGCGGTTTGCCGTGTGTGCCCGCGCTACTGAGTCACGTCATGTCCAGGAGGCCTGGTGCCACATCCGTCAGCTGGCATCAGAGCTGCTTCAGGAACTGCTACACTGACCATTGCAGTGGGCATCACAAttgtacactctcaaaaataaaggtatgctagttgtcactagggtggtaacttttcaaaaggtacaaatttgtacctaaaaggacCATATTAATACTTATTATATAGTTCTGAGGTACTAATATGGatccttcaagtacaaatgtgtacaaaaaggtaccaccccagtgacagctctcatacctttatttGTGAGAGTGTACCACATCTGCTTTCACACTGTCTTAATTCCCCTCTATCGCTGATTCATGCTATTTATTGGC

Function

symbol description
ddc Predicted to enable aromatic-L-amino-acid decarboxylase activity. Acts upstream of or within brain development. Predicted to be active in cytoplasm. Is expressed in digestive system; muscle; nervous system; ovary; and pharyngeal arch. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Orthologous to human DDC (dopa decarboxylase).

GO:

id name namespace
GO:0042427 serotonin biosynthetic process biological_process
GO:0006520 cellular amino acid metabolic process biological_process
GO:0007420 brain development biological_process
GO:0006584 catecholamine metabolic process biological_process
GO:0019752 carboxylic acid metabolic process biological_process
GO:0005737 cytoplasm cellular_component
GO:0030170 pyridoxal phosphate binding molecular_function
GO:0016829 lyase activity molecular_function
GO:0016831 carboxy-lyase activity molecular_function
GO:0004058 aromatic-L-amino-acid decarboxylase activity molecular_function
GO:0003824 catalytic activity molecular_function

KEGG:

id description
ko00260 Glycine, serine and threonine metabolism
ko00350 Tyrosine metabolism
ko00360 Phenylalanine metabolism
ko00380 Tryptophan metabolism
ko00901 Indole alkaloid biosynthesis
ko00950 Isoquinoline alkaloid biosynthesis
ko00965 Betalain biosynthesis
ko04728 Dopaminergic synapse
ko04726 Serotonergic synapse
ko04361 Axon regeneration
ko05030 Cocaine addiction
ko05031 Amphetamine addiction
ko05034 Alcoholism
ko04147 Exosome

ZFIN:

id description
ZDB-GENE-040426-2656 Predicted to enable aromatic-L-amino-acid decarboxylase activity. Acts upstream of or within brain development. Predicted to be active in cytoplasm. Is expressed in digestive system; muscle; nervous system; ovary; and pharyngeal arch. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Orthologous to human DDC (dopa decarboxylase).

Ensembl:

ensembl_id ENSDARG00000016494

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00020522 False 4117 mRNA 0.42 14 8298542 8342749
TCONS_00020523 True 814 lncRNA 0.41 2 8300824 8303179

Neighbor

gene id symbol gene type direction distance location
XLOC_010447 CR478208.1 coding downstream 10095 8287771 ~ 8288447 (-)
XLOC_010446 entpd3 coding downstream 17657 8258203 ~ 8280885 (-)
XLOC_010445 gask1a coding downstream 46557 8188188 ~ 8251985 (-)
XLOC_010444 NA coding downstream 156230 8140712 ~ 8142312 (-)
XLOC_010443 snrka coding downstream 165800 8047896 ~ 8132742 (-)
XLOC_010449 grb10b coding upstream 21336 8364085 ~ 8520474 (-)
XLOC_010450 CU062417.1 coding upstream 136131 8478880 ~ 8479009 (-)
XLOC_010451 cobl coding upstream 187023 8529772 ~ 8663552 (-)
XLOC_010452 NA coding upstream 326232 8668981 ~ 8679462 (-)
XLOC_010453 triob coding upstream 409066 8751815 ~ 8927425 (-)
XLOC_010626 CR392024.2 misc upstream 12552363 20895112 ~ 20895175 (-)
XLOC_010442 CU856516.1 non-coding downstream 313641 7968020 ~ 7984901 (-)
XLOC_010441 NA non-coding downstream 417265 7834219 ~ 7881277 (-)
XLOC_010438 BX511173.1 non-coding downstream 602326 7693881 ~ 7696216 (-)
XLOC_010455 CR394537.1 non-coding upstream 959330 9302079 ~ 9302194 (-)
XLOC_010458 FO704756.1 non-coding upstream 1221754 9564503 ~ 9566371 (-)
XLOC_010461 NA non-coding upstream 1416427 9759176 ~ 9761753 (-)

Expression


Co-expression Network