CI01000080_02122386_02126617 (LRRC8AA, LRRC8AB, LRRC8A)


Basic Information

Item Value
gene id CI01000080_02122386_02126617
gene name LRRC8AA, LRRC8AB, LRRC8A
gene type coding
species grasscarp (Ctenopharyngodon idella)
category of species economic fish

Chromosome Information

Item Value
chromosome id CI01000080
NCBI id null
chromosome length 5175454
location 2122308 ~ 2127055 (-)
genome version v1_2015/06_NatureGenetics_grasscarp_Genome

Sequence

>CI01000080_02122386_02126617.mRNA
CCATCCTGACATAAAGGACTGATGAGTGCCAGTTCCTGACTGGACATGTGGAGTATTAGGTGAGATCCAACTGAGGAGACACTGCTTCAGACACTGCCCTGCCTTAGACAAACAGGATTTGAACCCTGGGGTCACGGACTCTCCAAAGCCAGAGGAGACAATTCTTCTGTGTTATTATCGGAAATGGCTAATAATAGATGACAAGAAAGCCAGAGCATTCTTTTGGCGGAGTCTCCTTGTGTAACAGCCGGAGAAGACAGCCGTCCTCGAATTCGGTAAAATATGTTTCAGGTGTTTATGTTGGGAGATGATATAGAGTTAGTTTGTAATAGTGGGGCAATTTTAAATATCTGCTTGTGCATAGCATTGACAATCAAGGCATAATTTATAAGTATAGATGTTGTATGACCATGCCAATATTTTAATTTCAGGTAAATCATGATCCCCATAACTGAGCTGCGCTACTTTGTGGACACGCAACCTACGTATCGCATCCTAAAGCCATGGTGGGACGTGTTCACAGACTATTTATCGGTCGTAATGCTGATGATTGCAGTATTTGGGGGCACGCTTCAGGTCACACAGGACAAGATGATCTGTCTGCCCTGCAAATGGGTAGTTAACAAGACATGTAGGAAGTATTTCAATTCAACGTTTTCTGTGCCCTTGACCCTTGAACCTCAAGGAATCCAGTATGACCTTGATCGGCACCAATACAACTATGTCGACGCTGTGTGCTATGAAAACAAGCTTCACTGGTTTGCTAAGTATTTCCCATATTTGGTGCTGCTGCATACACTCATCTTTCTGGCTTGCAGCAACTTCTGGTTCAAGTTCCCTTGGACAAGCTCTAAATTGGAACATTTTGTGTCTATCCTCCTGAAATGTTTTGACTCGCCGTGGACCACACGAGCTCTGTCTGAAACTGTCGTGGAGGAAAGCGACCCCAAAGCTCTGGTGAAAATGAATGGCTCCTTCGATAAGAAGGCTTCATATGTTAGTGAAGACGTTGAAGCGAGTGTTCCCATGCTGTCCACAACCAGATCTCGTATTGAACAAGGAATCGTGGACCACTCTGATACTGGTGTCCTGGATAAAAAGGAAGGTGAACAAGCTAAGGCATTGTTTGAGAAGGTGAAGAAGTTTCGAATTCATGTTGAAGAAGGCGATATAGTCTACCGACTCTACATCCGACAGACTATCATCAAAGTTGTTAAGTTTATCCTTATTATCTGCTATACAGGCTACTATGTACACAATATTCAGTTCAGCGTCGACTGCAATGTGGACATCGAGAGTCTCACTGGTTATCGCATGTACAACTGTGCCCATCCCTTGGCCACTCTCTTCAAGATTTTAGCCTGCTTCTACATTAGTCTAGTTATTGTGTATGGCATGATCTGCGTATACACCCTCAGCTGGATGCTTCGACGTTCCCTCAAGAAGTACTCGTTTGAGTCTATCCGAGAGGAGAGCAGCTACAGCGATATTCCAGACGTGAAAAACGACTTCGCCTTCATGCTGCATATGATTGACCAGTACGACCCTCTCTATTCCAAGCGATTTGCGGTGTTCCTCTCAGAGGTCAGTGAGAACAAACTGCGCCAGCTGAACCTTAACAACGAATGGACTTTGGAAAAGCTTCGACAGAGGATCACCAAAAACTCCCAAGAGAAGTTGGAGCTCCACCTGTTCATGCTCAGTGGGATTCCAGACACAGTCTTTGACTTGGTGGAGTTGGAGGTTCTGAAGCTTGAACTCATTCCTGATGTCACCATCCCACCAATCATTGCCCAGCTTACTAACCTCAGAGAGATGTGGTTGTACCACACGCCAGCCAAAATAGAGGCTCCAGCGCTTGCATTTCTGAGAGAGAACCTGAAATCTTTGCACATCAAGTTCACCGACATAAAGGAGATTCCTCTGTGGATCTACAGCTTGAAGAACTTAAGCGAGTTGCATCTTACTGGGAACCTTAGTGCTGATAACAATCGCTACATCGTCATCGACGGTTTACGAGAGTTGAAGCGACTAAAGGTTTTGAGACTGAAAAGTAACTTAACAAAGCTGCCTCAGGTGGTCACGGATGTTGGAATGCACCTCCAGAAGCTGTCCATCAACAATGAAGGTACCAAGTTGATGGTGCTCAACAGCTTAAAGAAGATGGTGAACCTGTCAGAGCTGGAGCTTGTCCGCTGCGATCTGGAGCGCATACCGCATTCCATCTTCAGCCTGCACAATTTACAAGAGATTGATCTGAAGGACAACAACCTGAAAACCATTGAGGAGATCATTAGTTTTCAGCATCTTCATCGACTTGTTTGTCTAAAGTTGTGGTATAATCAGATTGCGTACATACCTATCCAGATAGGTACTTTGATCAACCTGGAGCGGCTGTATTTGAACCGTAACAAGATCGAGAAAATGCCACATCAGCTCTTCTTCTGCCGGAAGCTGAGGTTTCTTGATCTGAGCCATAACAATCTCACTGATATCCCATCAGAAATAGGAACTCTGCAGAACCTTCAGTACCTTGCTGTAACTGCCAATAGGATTGAAGCGCTCCCCCCTGAGTTGTTTCAGTGTAAGAAACTGCGAACGTTGAACCTCGGAAACAACTGCCTGCAGTCTCTACCCTCTCGGTTTGGGGAGCTCACCAGTCTGACGCAGCTGGAGCTGAGGGGCAACCGGCTCGAGTGCCTTCCTGTAGAACTTGGGGAGTGCAGATTGCTGAAGAGGAGTGGTCTAATTGTGGAGGACAATATTTTCAACACTTTACCTTCTGAGGTCAAAGAGCAGCTGTGGAGAACTGACAAAGAGGCTTCCTGAAGCAGATGAGCACTTGCCTGTGTGAAGATTTGAAATAGTGTGAGGAGAGGAATTCAGACCAAGCAATAGAAAATTAAA

Function

symbol description
lrrc8aa Enables volume-sensitive anion channel activity. Predicted to act upstream of or within ion transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in head; heart tube; otic vesicle; pectoral fin bud; and ventricular system. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to human LRRC8A (leucine rich repeat containing 8 VRAC subunit A).
lrrc8ab Predicted to act upstream of or within ion transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in head; heart tube; otic vesicle; pectoral fin bud; and ventricular system. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to several human genes including LRRC8A (leucine rich repeat containing 8 VRAC subunit A).
lrrc8a Enables cyclic-GMP-AMP transmembrane transporter activity; identical protein binding activity; and volume-sensitive anion channel activity. Contributes to anion channel activity. Involved in several processes, including anion transmembrane transport; cell volume homeostasis; and protein hexamerization. Located in cell surface and plasma membrane. Is integral component of lysosomal membrane and integral component of plasma membrane. Part of ion channel complex. Implicated in agammaglobulinemia and agammaglobulinemia 5.

GO:

id name namespace
GO:0016021 integral component of membrane cellular_component

KEGG: NA

RNA

RNA id representative length rna type GC content exon number start site end site
CI01000080_02122386_02126617.mRNA True 2907 mRNA 0.45 2 2122308 2127055

Neighbor

gene id symbol gene type direction distance location
CI01000080_02117016_02119929 PPIL3 coding downstream 2379 2116786 ~ 2119929 (-)
CI01000080_02113135_02116388 NA coding downstream 5920 2113094 ~ 2116388 (-)
CI01000080_02057026_02085109 PTGS1 coding downstream 37199 2055395 ~ 2085109 (-)
CI01000080_02015292_02021186 PMPCA coding downstream 100721 2014384 ~ 2021587 (-)
CI01000080_01993914_01996596 NA coding downstream 125686 1993448 ~ 1996622 (-)
CI01000080_02173438_02187618 OLFM1B, OLFM1A, OLFM1 coding upstream 46298 2173353 ~ 2188990 (-)
CI01000080_02305920_02313082 WDR5 coding upstream 177967 2305022 ~ 2313082 (-)
CI01000080_02333927_02334181 NA coding upstream 206125 2333180 ~ 2334648 (-)
CI01000080_02335056_02338218 EDF1 coding upstream 207765 2334820 ~ 2338271 (-)
CI01000080_02343279_02346069 NA coding upstream 215453 2342508 ~ 2346072 (-)
G292214 NA non-coding downstream 32070 2090005 ~ 2090238 (-)
G292197 NA non-coding downstream 129314 1992714 ~ 1992994 (-)
CI01000080_01980939_01981859 NA non-coding downstream 140522 1979746 ~ 1982199 (-)
G292176 NA non-coding downstream 155742 1962538 ~ 1966566 (-)
G292096 NA non-coding downstream 309336 1812411 ~ 1812972 (-)
G292242 NA non-coding upstream 83788 2210843 ~ 2211065 (-)
G292262 NA non-coding upstream 136559 2263614 ~ 2266106 (-)
G292339 NA non-coding upstream 364059 2491114 ~ 2517180 (-)
G292387 NA non-coding upstream 606532 2733587 ~ 2743246 (-)
G292409 NA non-coding upstream 626080 2753135 ~ 2754693 (-)
G292089 NA other downstream 450388 1635762 ~ 1693395 (-)
G290314 NA other downstream 1714164 407885 ~ 408144 (-)
G290261 NA other downstream 1792791 327689 ~ 329517 (-)
G290197 NA other downstream 1842461 272397 ~ 279847 (-)
G292349 NA other upstream 391023 2518078 ~ 2525409 (-)
CI01000080_03207204_03212602 NA other upstream 1081930 3207204 ~ 3212913 (-)
G292714 NA other upstream 1588426 3715481 ~ 3728010 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location