XLOC_010916 (tgfbr2b)


Basic Information

Item Value
gene id XLOC_010916
gene name tgfbr2b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007127.7
NCBI id CM002900.2
chromosome length 55266484
location 39505163 ~ 39605661 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00021355
CACAGTGACTGTTGACTCCAGCAGAATGAGACGCGCTCCTTCAGTCCGGATCACACGATAAAACCCACTCTTTCTGCTCAAAAAACGCCTGCTTGATTACATTCACATTAATGCGAGGGATACGGGCTCGACTGCGTTTCTAATGGAGCGATATCAGCTTTCTGTGCTCTGCTGGTGGACTTTTTTGATTTCTACAGTTGTGGATTGGCGCGGAGTCGATGGAAATAATCCTTTTTACCGTCCCTATCGGATTCCTCAACTATGTAAATTCTGTGATGTGTTGGAAAGCAACTGCAATGGCAAAGACACCTGTGAAAGCAACTGCTCCATCACGTCCATCTGTGAGAGTCCAGATGAGATCTGTGTGGCTATCTGGAGGCAGAGTGATGACAACAACACAATCGAGACGTTGTGCCACAACCCCACCGTGCCCCTCTACGGCATCATGGTggagaacaacaacaacaccaagtGCGAAATGAAAAAGAGGATTTCAAACAGCGGCCCTTTCCACATCTGCTCCTGCAACGAGGTAGAGTGCAACGACATGCTGCTGTTCAAACTTCCCACCAATAACCAGGTGGTGTTGGTGATCCTGGTCAGTCTTCTGCCTCTGCTGGTTCTGGCTGTGCTGGTCATCGCCTCCTTCTACTGGTATCGCATGTACCGCCGCAGAAAACTCGACGAGTGGGAGACCAAGAAGCCTTCTAAACACAAGGGTCCCAAAGGCCCTCTGGACTGCAGTGACGCCTGCGCCATCATGATGGATGACGACCGCTCAGACAGCAGCTCCACACATGCCAACAACATCAATCACAACATGGATCCGCTGCCCATCGAGCTCGACCTGCAGGTGGGCAAGGGCCGCTTCGCTGAGGTGTACAAAGCCAAGCTGAGACAAAGCCCTTCAGAGCAGTTCGAGACAGTAGCAGTAAAGATCTTCCCCTATGAAGAGTACGCGTCCTGGAAGAACGAGAAGGACATCTTTCAGGACATCGACCTGAAGCACGAGAACATCCTGCACTTCCTAACAGCAGAGGAGCGCAAGGTGGAGAAACAGTACTGGCTGATCACAGCGTTTCACCCACGGGGGAACCTGCAGGAGTACTTGATGCGCCACTTGCTCAGCTGGGAAGACCTGCGGCTGCTTGGCAGTTCCCTGGCAAGTGGCGTGGCTCATTTGCATAGTGACCACACACCCTGTGGGAGACCCAAAGTGCCCATCGTCCATCGGGACCTCAAGAGTTCCAACATCCTGGTGAAGAACGACCTGACATGTTGTCTCTGTGACTTCGGGCTCGGGCTTCGTTTGGACAACTCGCTGTCGGTGGATGAACTGGCTAACAGTGGACAGGTGGGTACAGCCCGGTACATGGCTCCAGAGGTGCTGGAATCGAGGATCAACCTTGAAAACATTGAGTCCTTCAAGCAAACCGATGTCTACTCTATGGCTCTAGTGCTGTGGGAAATCACGTCCAGATGTAACGCCATCGGAGAGGTTAAAGACTATGAACCTCCATTTGGCTCTAAAGTCCGAGAGCACCCCTGTGTGGAGAGCATGAAAGACAATGTGCTGCGAGACCGAGGCAGGCCAGAGATCCCCAGCAGCTGGATGAAACACCAGGGAGTGGCAGCAGTTTGTGCAACCATCAATGAATGCTGGGATCACGACCCTGAAGCCCGGCTGACTGCACAGTGTGTGGCTGAACGCTTCAACGAGATGGACGACGACCTGGACAAACTGTCCACCTGCAGCAGCTCTGAGGAAAAGATTCCCGAAGACTGTGCCGTGAGCGTGAGCGACGACAAATGAGAGAAAGATCTCTCTCtgcacaaactgaatgttgtacATCCTTCCAGCGAGGCGACGTAGAAGAATACGGCCTTTTCATAAAGCTTTATGTCTCATAACCAAAGATTTCATGCACTTTATCAGATTATTCACAGCTCACACTGAGGAAGGTCACGCTGCGAGAAAGAGGAGCTGGACAGATGCTGGGTTTCTCCTCTGACGGCTGACCGAGAGCCAAAGGTAATCAGGAAAATGTTTCGCCTCAACACTAAAGATTCATAGGAGATTTTAAGACTTCCTACAGATCAGTTCTGGATTTTCTGGATTTATGGAAGAATGTGAGATTTGTTTGTTTGCGTGCATgaatggtgtgtgtgtttgtttttgccaAAAAGTGTATTGTGCTTGTTATAGCCaaaggaaaaatatattttaaatacagctTGTGACGTAAAAAAAA
>TCONS_00021356
CGAGTCATTGAACCGAACCGATTCTATTCATTTAACAAAGCTGATTCATTCAACGCATTGTCACAACTGTAAAATCATCTTGGAAATCATTGGGCGAACTAAAATGGACGGAGTATCGGGAAATGTGCTCTCTGACAGATGGAAATAATCCTTTTTACCGTCCCTATCGGATTCCTCAACTATGTAAATTCTGTGATGTGTTGGAAAGCAACTGCAATGGCAAAGACACCTGTGAAAGCAACTGCTCCATCACGTCCATCTGTGAGAGTCCAGATGAGATCTGTGTGGCTATCTGGAGGCAGAGTGATGACAACAACACAATCGAGACGTTGTGCCACAACCCCACCGTGCCCCTCTACGGCATCATGGTggagaacaacaacaacaccaagtGCGAAAT

Function

symbol description
tgfbr2b Predicted to enable several functions, including activin binding activity; transforming growth factor beta binding activity; and transmembrane receptor protein serine/threonine kinase activity. Acts upstream of or within hematopoietic stem cell differentiation. Predicted to be located in membrane raft. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; head; mesoderm; and trigeminal ganglion. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 2; Marfan syndrome; gastrointestinal system cancer (multiple); hereditary nonpolyposis colorectal cancer type 6; and pancreatic cancer. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2).

GO:

id name namespace
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway biological_process
GO:0007179 transforming growth factor beta receptor signaling pathway biological_process
GO:0006915 apoptotic process biological_process
GO:0007507 heart development biological_process
GO:0030154 cell differentiation biological_process
GO:0071363 cellular response to growth factor stimulus biological_process
GO:0006468 protein phosphorylation biological_process
GO:0060218 hematopoietic stem cell differentiation biological_process
GO:0040008 regulation of growth biological_process
GO:0016310 phosphorylation biological_process
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0043235 receptor complex cellular_component
GO:0038023 signaling receptor activity molecular_function
GO:0017002 activin-activated receptor activity molecular_function
GO:0034713 type I transforming growth factor beta receptor binding molecular_function
GO:0048185 activin binding molecular_function
GO:0016740 transferase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0046332 SMAD binding molecular_function
GO:0050431 transforming growth factor beta binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0004675 transmembrane receptor protein serine/threonine kinase activity molecular_function
GO:0016301 kinase activity molecular_function
GO:0005024 transforming growth factor beta-activated receptor activity molecular_function
GO:0005026 transforming growth factor beta receptor activity, type II molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-980526-375 Predicted to enable several functions, including activin binding activity; transforming growth factor beta binding activity; and transmembrane receptor protein serine/threonine kinase activity. Acts upstream of or within hematopoietic stem cell differentiation. Predicted to be located in membrane raft. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; head; mesoderm; and trigeminal ganglion. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 2; Marfan syndrome; gastrointestinal system cancer (multiple); hereditary nonpolyposis colorectal cancer type 6; and pancreatic cancer. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2).

Ensembl:

ensembl_id ENSDARG00000034541

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00021355 False 2252 mRNA 0.50 8 39505163 39570832
TCONS_00021356 True 400 processed_transcript 0.45 3 39557786 39605661

Neighbor

gene id symbol gene type direction distance location
XLOC_010915 stt3b coding downstream 27417 39385483 ~ 39477746 (-)
XLOC_010914 gpd1l coding downstream 237936 39248644 ~ 39267227 (-)
XLOC_010913 tmem42a coding downstream 263362 39237768 ~ 39241801 (-)
XLOC_010912 ebag9 coding downstream 309845 39185103 ~ 39195318 (-)
XLOC_010911 si:dkey-99n20.6 coding downstream 326184 39172842 ~ 39178979 (-)
XLOC_010917 NA coding upstream 7233 39612894 ~ 39625362 (-)
XLOC_010918 rbms3 coding upstream 37607 39643268 ~ 39900665 (-)
XLOC_010919 CR626944.1 coding upstream 279473 39885134 ~ 39885251 (-)
XLOC_010920 CT025588.1 coding upstream 431050 40036711 ~ 40037796 (-)
XLOC_010921 si:dkey-29b11.3 coding upstream 435152 40040813 ~ 40043322 (-)
XLOC_010626 CR392024.2 misc downstream 18609988 20895112 ~ 20895175 (-)
XLOC_010909 BX296552.2 non-coding downstream 395232 39029883 ~ 39109931 (-)
XLOC_010908 NA non-coding downstream 480166 39000013 ~ 39024997 (-)
XLOC_010907 NA non-coding downstream 555016 38948644 ~ 38950147 (-)
XLOC_010905 NA non-coding downstream 701011 38802405 ~ 38804152 (-)
XLOC_010904 CU855886.1 non-coding downstream 942519 38562527 ~ 38562644 (-)
XLOC_010923 NA non-coding upstream 730820 40336481 ~ 40340518 (-)
XLOC_010927 BX324007.2 non-coding upstream 916077 40521738 ~ 40584050 (-)

Expression


Co-expression Network