XLOC_013453 (idh2)


Basic Information

Item Value
gene id XLOC_013453
gene name idh2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007129.7
NCBI id CM002902.2
chromosome length 51023478
location 26096814 ~ 26101800 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00026561
TCTATCACCGGCTTCGCTCACAGCTGCTTCCAGTACGCCATCCAGAAGAAATGGCCTCTCTACATGAGCACCAAGAACACCATCCTGAAGGCTTATGACGGCAGATTCAAGGACATCTTCCAGGATATCTTTGAGAAAAACTACAAGCCAGAGTTTGACAAGCTGAAGATCTGGTATGAACACAGACTGATtgatgacatggtggctcaggTGCTGAAGTCATCCGGTGCCTTTGTGTGGGCCTGCAAGAACTATGATGGAGATGTGCAGTCGGACATTCTTGCTCAGGGTTTCGGTTCTCTGGGTTTGATGACCTCAGTTCTGGTGTGTCCTGATGGTAAGACCATTGAAGCCGAGGCAGCACACGGCACAGTAACCAGGCATTACCGTGAGCACCAGAAGGGAAGGCCAACTAGCACTAACCCCATTGCCAGCATCTTCGCATGGACTAGAGGACTGGAACACCGTGGCAAACTTGATGGAAACCCAGACCTGATCAAGTTCTCTCAAACTCTTGAACGTGTGTGCGTGGAGACTGTGGAGAGCGGCGTTATGACCAAGGATCTGGCCGGCTGCATTCACGGTCTCGCCAACTGCAAGCTGAATGAGCATTACGTCAACACCACAGACTTCCTGGATGCCATCAAGACAAACCTGGACAAGGCTCTGGGCAAATGAAGGACAACAGGCCCGGACACCGCGGAGCGCGTCTGTCTTTTTGTACCTCATTTTTAACTTAAAGGTCATGAATACAACATAATGTATTAAGGGAGGAGTAATAAAACAATAGTGATGTTCCTAGCTGTTCTGTTAGCTAATCCTGCTGATGGGTCGCTCCCATCTCTTCCCGAACCTCCAGGGGTCTATTTTTGTAAGATGAAGtactgtatgtcagaaactgtataATACCACAGGAGAAAAGGAAAGTTCAAGGGCCATGTGAGAAACCCTCTAATAAATCACCAAGTCACCTGG

Function

symbol description
idh2 Predicted to enable NAD binding activity; isocitrate dehydrogenase (NADP+) activity; and magnesium ion binding activity. Predicted to act upstream of or within glyoxylate cycle; isocitrate metabolic process; and tricarboxylic acid cycle. Is expressed in several structures, including blastoderm; brain; digestive system; pectoral fin bud; and renal system. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; hepatocellular clear cell carcinoma; intrahepatic cholangiocarcinoma; and lung cancer. Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2).

GO:

id name namespace
GO:0006099 tricarboxylic acid cycle biological_process
GO:0006102 isocitrate metabolic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0046872 metal ion binding molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0051287 NAD binding molecular_function
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function
GO:0004450 isocitrate dehydrogenase (NADP+) activity molecular_function
GO:0000287 magnesium ion binding molecular_function

KEGG:

id description
ko00020 Citrate cycle (TCA cycle)
ko00720 Carbon fixation pathways in prokaryotes
ko00480 Glutathione metabolism
ko04146 Peroxisome
ko05230 Central carbon metabolism in cancer

ZFIN:

id description
ZDB-GENE-031118-95 Predicted to enable NAD binding activity; isocitrate dehydrogenase (NADP+) activity; and magnesium ion binding activity. Predicted to act upstream of or within glyoxylate cycle; isocitrate metabolic process; and tricarboxylic acid cycle. Is expressed in several structures, including blastoderm; brain; digestive system; pectoral fin bud; and renal system. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; hepatocellular clear cell carcinoma; intrahepatic cholangiocarcinoma; and lung cancer. Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2).

Ensembl:

ensembl_id ENSDARG00000003795

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00026561 True 975 mRNA 0.49 6 26096814 26101800

Neighbor

gene id symbol gene type direction distance location
XLOC_013452 sema4ba coding downstream 191191 25783446 ~ 25905623 (-)
XLOC_013451 zgc:162879 coding downstream 325261 25754838 ~ 25771553 (-)
XLOC_013450 NA coding downstream 351193 25697275 ~ 25745621 (-)
XLOC_013449 si:ch211-13k12.2 coding downstream 450528 25563292 ~ 25646286 (-)
XLOC_013448 CR450716.1 coding downstream 580183 25515893 ~ 25516631 (-)
XLOC_013454 CABZ01039782.1 coding upstream 22863 26124663 ~ 26126258 (-)
XLOC_013455 dre-mir-184-1 coding upstream 101503 26203303 ~ 26203389 (-)
XLOC_013456 CR352253.1 coding upstream 194365 26296165 ~ 26299843 (-)
XLOC_013457 FRMD5 coding upstream 358644 26460444 ~ 26675699 (-)
XLOC_013458 malt3 coding upstream 548060 26649860 ~ 26715655 (-)
XLOC_013384 BX323829.1 misc downstream 6554583 19542102 ~ 19542231 (-)
XLOC_013445 NA non-coding downstream 871378 25180539 ~ 25225436 (-)
XLOC_013444 BX901968.2 non-coding downstream 938037 25158661 ~ 25158777 (-)
XLOC_013441 NA non-coding downstream 1099744 24990268 ~ 24997070 (-)
XLOC_013467 NA non-coding upstream 953046 27054846 ~ 27066350 (-)
XLOC_013468 CR936464.1 non-coding upstream 1035065 27136865 ~ 27136982 (-)
XLOC_013469 BX640463.3 non-coding upstream 1205124 27306924 ~ 27307040 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000013_00862608_00869073 IDH2, IDHP, IDH2.S coding CI01000013 null 862418 ~ 869073 (+)
bowfin (Amia calva) AMCG00007813 idh2,LOC107714782,LOC107691122,LOC107715227 coding CM030123.1 CM030123.1 31111645 ~ 31136247 (+)