XLOC_013498 (mc1r)


Basic Information

Item Value
gene id XLOC_013498
gene name mc1r
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007129.7
NCBI id CM002902.2
chromosome length 51023478
location 31226288 ~ 31227615 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00026615
AATTCTTATTATTACCTATTCGTttggggggaacaaatgttggaCTTTCTGGAACTGATCGTGGTGAATTAAACAGAACTGTCTTTTTTTAATATGAAAGGTGTGCTTAAGGAAAACGAAAATTCTATCAAGCTCAAAAGGACTGTGGAAGGGCAGACACTGAGTTAAGGAGCATGAACGACTCTTCGCGCCATCACTTCAGCATGAAACACATGGACTATATGTATAATGCTGACAATAATATCACTTTAAACAGCAACTCAACAGCCAGCGACATAAATGTCACAGGGATCGCCCAGATTATGATCCCTCAGGAACTttttctaatgctcggtttgatcAGTTTGGTAGAAAACATCTTGGTGGTTGTGGCAATCATCAAGAACAGGAATCTTCATTCGCccatgtattattttatttgctgTCTGGCGGTGGCAGACATGCTAGTGAGCGTCAGTAATGTGGTGGAGACGTTGTTTATGTTACTGACGGAGCATGGGCTACTGCTGGTCACCGCAAAAATGTTGCAGCACTTAGATAATGTTATTGACATTATGATATGTAGTTCTGTTGTGTCTTCTTTGTCGTTTCTGTGCACCATTGCGGCGGACCGTTATATCACCATCTTTTACGCACTCCGGTACCACAGTATCATGACTACGCAGCGCGCCGTGGGCATCATCTTGGTGGTGTGGCTTGCCAGCATCACCTCTAGTTCTTTGTTTATCGTTTATCACACGGACAATGCGGTCATCGCCTGTCTCGTGACTTTTTTCGGCGTGACGTTGGTGTTCACGGCGGTTCTGTACCTGCACATGTTCATCTTGGCCCATGTCCACTCAAGACGCATCACGGCTCTCCATAAGAGCCGTCGGCAGACCACTAGCATGAAGGGAGCCATCACTCTGACTATCCTGCTTGGAGTTTTCATCCTCTGCTGGGGACCGTTCTTCCTCCACCTCATCCTAATTCTCACCTGTCCCACAAACCCTTACTGCAAGTGCTATTTCAGCCATTTCAACCTATTTCTGATTCTTATCATATGCAACTCGCTTATAGACCCTCTCATTTACGCTTACCGCAGTCAGGAGCTGCGCAAAACTCTCAAAGAACTAATTTTTTGTTCGTGGTGCTTTGCAGTGTAAGCTATTATTTCGCTTGCTTGCTTGTCATTACTGACGCttaaaaaaagtataatgttCAATCTGCTAATGTTGCCTTTTATTGCAGTATTGCGTCTTGTGACACTAATTTTACAGAGAATACAATGTGATGTTTACTGAGATAATTAGATCTTTTGTTTTAGCTTTTGGGCACAAACATTTTGA

Function

symbol description
mc1r Predicted to enable melanocyte-stimulating hormone receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including endocrine system; female organism; integument; male organism; and nervous system. Human ortholog(s) of this gene implicated in familial melanoma; major depressive disorder; melanoma; oculocutaneous albinism type II; and pigmentation disease. Orthologous to human MC1R (melanocortin 1 receptor).

GO:

id name namespace
GO:0007186 G protein-coupled receptor signaling pathway biological_process
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway biological_process
GO:0019222 regulation of metabolic process biological_process
GO:0007165 signal transduction biological_process
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005515 protein binding molecular_function
GO:0004930 G protein-coupled receptor activity molecular_function
GO:0004977 melanocortin receptor activity molecular_function
GO:0004980 melanocyte-stimulating hormone receptor activity molecular_function

KEGG:

id description
ko04080 Neuroactive ligand-receptor interaction
ko04916 Melanogenesis
ko04030 G protein-coupled receptors

ZFIN:

id description
ZDB-GENE-030502-1 Predicted to enable melanocyte-stimulating hormone receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including endocrine system; female organism; integument; male organism; and nervous system. Human ortholog(s) of this gene implicated in familial melanoma; major depressive disorder; melanoma; oculocutaneous albinism type II; and pigmentation disease. Orthologous to human MC1R (melanocortin 1 receptor).

Ensembl:

ensembl_id ENSDARG00000020237

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00026615 True 1328 mRNA 0.43 1 31226288 31227615

Neighbor

gene id symbol gene type direction distance location
XLOC_013497 pdcd5 coding downstream 120897 31089957 ~ 31105391 (-)
XLOC_013496 gas8 coding downstream 174441 31033122 ~ 31051847 (-)
XLOC_013495 NA coding downstream 265219 30960172 ~ 30961069 (-)
XLOC_013494 FO834814.1 coding downstream 370753 30854496 ~ 30855535 (-)
XLOC_013493 NA coding downstream 472865 30752484 ~ 30753423 (-)
XLOC_013499 CU570893.1 coding upstream 71461 31299076 ~ 31423569 (-)
XLOC_013500 NA coding upstream 496491 31724106 ~ 31724812 (-)
XLOC_013501 NA coding upstream 505008 31732623 ~ 31737816 (-)
XLOC_013502 olfcs2 coding upstream 685144 31912759 ~ 31916845 (-)
XLOC_013503 olfcs1 coding upstream 737732 31965347 ~ 31969939 (-)
XLOC_013384 BX323829.1 misc downstream 11684057 19542102 ~ 19542231 (-)
XLOC_013487 BX908800.1 non-coding downstream 1307183 29918062 ~ 29919105 (-)
XLOC_013485 NA non-coding downstream 1823272 29397940 ~ 29403016 (-)
XLOC_013504 BX908386.2 non-coding upstream 777443 32005058 ~ 32009056 (-)
XLOC_013505 NA non-coding upstream 811886 32039501 ~ 32042362 (-)
XLOC_013507 BX649622.1 non-coding upstream 919093 32146708 ~ 32147630 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000359_00692067_00693038 MC1R, TUBB3 coding CI01000359 null 691985 ~ 693263 (+)