XLOC_013914 (apoea)



Basic Information


Item Value
gene id XLOC_013914
gene name apoea
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information


Item Value
chromosome id NC_007130.7
NCBI id CM002903.2
chromosome length 48449771
location 10855158 ~ 10859694 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence


>TCONS_00027805
AGAACGACTGCGATCCAAGCAGTATAAATAACAGCTCTTTCCAAAGGACTTCCTTACAGAGCCCATCTGTCTGGTGTACTGTCCAAATACAATCATGAAGTTTGTGGCTGTAATTGTTGCGCTCGCCGTCATTTCAGGCTGCCAGGGGCGATTCCTGTTTCAGGATGAGCCAAGAAGCCGCTGGGAAGAGGCCGTGGATCAGTTCTGGAACCATGTTTCTGAACTGACCACTAGAGCTGAGGAAATGAGGGACAACATCAAGGCCACTCAGCTCGGCAGAGAATTAGACACACTGATCTCTGACAGCATGATGGAGCTGCAAATGTACAGAGATGATCTGCACTCCAAACTGGCCCCTTACGCGCAGGAGAGAGCCCAGAAGTTCAACGAAGATCTGCAGTTGTTGGTCACCAAGCTCCGCACACACATGGAGGAGGCGAAGGATCGTGTCACTGAATACACAGAGGAGCTCCGGACCATGGTGGAGCAGAACTCTGATGAGCTCAAGAACAAAGCTAACTCCTATGCCAAGAAATTAAGGAAACGATTTAACAAGGACATCCAGGAGATCAACAAAAAAATGTCAACATACCTTGAGGAGGTTCAGTCTCGTGCTTCACAGAGCGTGGAAGATGTGAAGGATCGTCTGGAGCCTTACTTCACGTCGATGCACGAGCGCGCTCAACAGAAGCTGGTGAATCTGAGAGAAGCGCTGAGAAGCCAGGCTGAGGAAATAAAGGAGAGACTGGACTCACGAATGCAGGAGCTCAGAGATCAAGTTGAGAAGACCAAAGAGAATGTGCACAACACTCTTCAGCAAAAGGCAGAGGATGTACAAAAGTGGTTTGAGCCCTACGTCTCTCACATCCAGAAGCAAATGGAGCCAGTCTGGGAGAGCCTTTAATGCCAGTGAATAACCTCATTCAAGACTTTTTCCACTTAACTTGAATTTCAGAAATAAAGCAATTGGAAATGTAAAGGTGATGGGAAATTGACCAGCAGAACTACATGTATGCGGCTACAGATGTAGCCAATGTAAGATCAATAAAGAAGCATGTACCACTG
>TCONS_00027806
TCAGGTAGGAAATAAACAACAATGCAAATTCCTTTGCTTTTTTTACCTGTTATAACCTTTATAATTAATTTAGCAAACATTAATAGAGATTTTATTTCTCTTTTGGAccaaatcatttaaatgttagCATTTTTTTCAGCACTTCGAACTACATTGATtacattgacagttttattgactGTCTTTCTTTAAGAACTTGATGCTATAAATGCGCTAACAAACACTGTTGCTGCTTGTTGTAAACTGTtcatataaaatgaaacaactAAATTCTCAaggtttttggggacaacttaattgttttatgtacatgccaattaaatttgtcaaaacaattAAGAtatcttaatcgatttgtgttgggacaacaagaaggaattgtgtggaacccaggattTACAGTGAATATTCCACACACTAAAGAATATTTGTGCTCCGTTTTGACTTTGCAGGCTGCCAGGGGCGATTCCTGTTTCAGGATGAGCCAAGAAGCCGCTGGGAAGAGGCCGTGGATCAGTTCTGGAACCATGTTTCTGAACTGACCACTAGAGCTGAGGAAATGAGGGACAACATCAAGGCCACTCAGCTCGGCAGAGAATTAGACACACTGATCTCTGACAGCATGATGGAGCTGCAAATGTACAGAGATGATCTGCACTCCAAACTGGCCCCTTACGCGCAGGAGAGAGCCCAGAAGTTCAACGAAGATCTGCAGTTGTTGGTCACCAAGCTCCGCACACACATGGAGGAGGCGAAGGATCGTGTCACTGAATACACAGAG

Function


symbol description
apoea Predicted to enable lipid binding activity. Predicted to be involved in several processes, including cholesterol catabolic process; lipoprotein catabolic process; and positive regulation of nitric-oxide synthase activity. Predicted to act upstream of or within lipid transport and lipoprotein metabolic process. Predicted to be located in extracellular region. Predicted to be part of intermediate-density lipoprotein particle. Is expressed in brain; female organism; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).

GO:

id name namespace
GO:1900221 regulation of amyloid-beta clearance biological_process
GO:0042157 lipoprotein metabolic process biological_process
GO:0042159 lipoprotein catabolic process biological_process
GO:0006707 cholesterol catabolic process biological_process
GO:0051000 positive regulation of nitric-oxide synthase activity biological_process
GO:0043524 negative regulation of neuron apoptotic process biological_process
GO:0006869 lipid transport biological_process
GO:0005576 extracellular region cellular_component
GO:0034363 intermediate-density lipoprotein particle cellular_component
GO:0008289 lipid binding molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-010724-18 Predicted to enable lipid binding activity. Predicted to be involved in several processes, including cholesterol catabolic process; lipoprotein catabolic process; and positive regulation of nitric-oxide synthase activity. Predicted to act upstream of or within lipid transport and lipoprotein metabolic process. Predicted to be located in extracellular region. Predicted to be part of intermediate-density lipoprotein particle. Is expressed in brain; female organism; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).

Ensembl:

ensembl_id ENSDARG00000102004

RNA


RNA id representative length rna type GC content exon number start site end site
TCONS_00027805 False 1065 mRNA 0.47 4 10855158 10859694
TCONS_00027806 True 781 mRNA 0.40 2 10855291 10856175

Neighbor


gene id symbol gene type direction distance location
XLOC_013913 apoa4a coding upstream 4324 10845953 ~ 10850834 (+)
XLOC_013912 tomm40l coding upstream 10071 10831362 ~ 10845087 (+)
XLOC_013911 lipea coding upstream 28443 10794072 ~ 10826715 (+)
XLOC_013910 ago3b coding upstream 168445 10661520 ~ 10686713 (+)
XLOC_013909 si:dkey-211g8.8 coding upstream 247782 10603405 ~ 10607376 (+)
XLOC_013915 si:ch73-347e22.4 coding downstream 791 10860485 ~ 10872469 (+)
XLOC_013916 si:ch73-347e22.8 coding downstream 78238 10937932 ~ 10950839 (+)
XLOC_013917 si:ch1073-70f20.1 coding downstream 120289 10979983 ~ 10986661 (+)
XLOC_013918 CU628002.1 coding downstream 153928 11013622 ~ 11014858 (+)
XLOC_013919 si:ch73-109i22.2 coding downstream 354313 11214007 ~ 11230837 (+)
XLOC_013906 CR384101.1 non-coding upstream 287672 10567371 ~ 10567486 (+)
XLOC_013895 NA non-coding upstream 988436 9838182 ~ 9866722 (+)
XLOC_013893 BX927218.1 non-coding upstream 1098142 9751075 ~ 9757016 (+)
XLOC_013889 dre-mir-125a-2 non-coding upstream 1411280 9443772 ~ 9443878 (+)
XLOC_013888 dre-let-7d-2 non-coding upstream 1425214 9429857 ~ 9429944 (+)
XLOC_013922 CU928061.1 non-coding downstream 418719 11278413 ~ 11278529 (+)
XLOC_013928 NA non-coding downstream 1435756 12295450 ~ 12300891 (+)
XLOC_013935 AL844521.1 non-coding downstream 2085156 12944850 ~ 12944966 (+)
XLOC_013937 NA non-coding downstream 2255571 13115265 ~ 13115526 (+)

Expression



Co-expression Network