XLOC_014286 (sesn2)


Basic Information

Item Value
gene id XLOC_014286
gene name sesn2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007130.7
NCBI id CM002903.2
chromosome length 48449771
location 43341115 ~ 43357457 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00028390
GTTACCGGCGGGTTGCGTCATGCTGCGCCGGCGAGGTGATGCAACAGTCCGGGTCTGTGTGTTCAGTAGCCACGCCTCCTGCCGgACGAAGCAGATGACCTCCCTGAGGTGTTGCCTTCCGGGCCCAGTGCCTTTATTCCAACTGAAGAGATTCTGGAGGAAGGATCCACACATGAAGTGATGTCAGACGTTTTGTTGTCAGAAGGACGTGCTGATCATATCAACATGGTGATGGGGCTTCATCCCACCTACCTGGCCTGTTTCCAGCGCACACAGGATGCTTTGCTCCAGCTGGACGGCCCACTGCCCTTATCATGGAGACATTATATAGTCATTTTGGCGGCTGCTCGTCATCAGTGCTCGTATCTCGTGCAGCATCACAGCTCCGCTTTTCTGCTTGCCGGTGGAGACGAGTCCTGGCTGCGGGGAGTTCACTGTGCACCACCGAAAATACAGCATCTGCAGACACTCAACAAACTGCTGGCACACAGACCCTGGATCATCACCCAGGAGCACATACAGGAGTTAGTTTGTCCCGGTGCGGAGGCTCGATGGTCTCTTGCGGAGCTGATTCAGGCGGTGGTTTTGATGACACACGCTCACTCTCTGGCCTCGTTTGTCTGGGGTTGCGGGATTCATCCAGAGCCTGAGCAGACAGAAGATCAGACGCTTCAGCCGTGTTCGCCCACAGACTCCTGTTGTTCAGTGCGGGGCAAGGCCAGAAATCAGCAGGAGtggTCTGAGGCTGTAAACGAGGTTAAGCTTTTGATGGAGAGGATGATGATGGTTCAACAGCAAGGTGAAGAGTTTACTCAGGAGGAGATGGTCACTCGCTTTGAAAGAGAGAGAACGGAGAGTTTGCTGGAACCTGCTGATG
>TCONS_00028391
TTCAGTAGCCACGCCTCCTGCCGGTGCGTTTCCTGCTTTCCTAAAACTAATGTTACACTCCAACAGGCACAATGAAATCATAAAACACAAACCCTGCGGGACTTAACTTCATCTTTATTCTGTTTCACCTGAGTCTACCGAACACATAAACACGTCTGATGAAGgACGAAGCAGATGACCTCCCTGAGGTGTTGCCTTCCGGGCCCAGTGCCTTTATTCCAACTGAAGAGATTCTGGAGGAAGGATCCACACATGAAGTGATGTCAGACGTTTTGTTGTCAGAAGGACGTGCTGATCATATCAACATGGTGATGGGGCTTCATCCCACCTACCTGGCCTGTTTCCAGCGCACACAGGATGCTTTGCTCCAGCTGGACGGCCCACTGCCCTTATCATGGAGACATTATATAGTCATTTTGGCGGCTGCTCGTCATCAGTGCTCGTATCTCGTGCAGCATCACAGCTCCGCTTTTCTGCTTGCCGGTGGAGACGAGTCCTGGCTGCGGGGAGTTCACTGTGCACCACCGAAAATACAGCATCTGCAGACACTCAACAAACTGCTGGCACACAGACCCTGGATCATCACCCAGGAGCACATACAGGAGTTAGTTTGTCCCGGTGCGGAGGCTCGATGGTCTCTTGCGGAGCTGATTCAGGCGGTGGTTTTGATGACACACGCTCACTCTCTGGCCTCGTTTGTCTGGGGTTGCGGGATTCATCCAGAGCCTGAGCAGACAGAAGATCAGACGCTTCAGCCGTGTTCGCCCACAGACTCCTGTTGTTCAGTGCGGGGCAAGGCCAGAAATCAGCAGGAGtggTCTGAGGCTGTAAACGAGGTTAAGCTTTTGATGGAGAGGATGATGATGGTTCAACAGCAAGGTGAAGAGTTTACTCAGGAGGAGATGGTCACTCGCTTTGAAAGAGAGAGAACGGAGAGTTTGCTGGAACCTGCTGATGTTCAGCGCTCCGTCCTTCCCGATTGTGTGTCGCGGTTTGTCGTGGACGCAGATTTTACTTATCAGGATTTTAGTCCTAGAGGAGCACAGGCCCCTCCAACCATGAGAGCTCAGGACTATTCATGGGAGGATCACGGCTTCTCTCTGATGAACCGGCTGTATGGGGAGATGGCGCAGCTTCTGGATGAGAAGTTTCAGGTGGCCTGTGCGCTCACGTATCACACCATGGCCATGCACTCACACGTGGACACATCCACACTGCGCAAAGCCATCTGGAACTACATTCAGTGCATCTACGGCATCAGATATGATGATTACGATTATGGGGAAGTGAACCAGCTGCTGGAGCGCAGTTTAAAAGTCTATGTAAAGACTGTGGCTTGTCACCCGGAGAAAACCACAGCAAGAATGTACTTCTCGTTTTGGAGGCAGTTTCGACACTCTGAAAAGGTCCATGTGAACCTGTTACTGATGGAGGCACGAATGCAGGCAGCTTTACTTTATGCTCTCAGAGCAATTACACGCTACATGACctaacacacgcgcacacgcacacacaaacacacacaagctctATTTAAAGCATTGAAATGCAGGATGACCTGTAAACACTATCATTCTCTGATTGTagcatgttttacacacacattgCACATTATTCCTCTAAAGCACAAAAGGTTTCTGttcagtttgttttttcttttctttttctttctttggcTTCTGCTGGATTTGGGAAGCAGTGAATTTTGCACATCTCCTGAGTAAACTTGTGACTCTTGTGGtactgtgaatgtgtgtttgccCTGCTGCAGTATTCTCTTCGGTGTGTTTCTGTGAATGTTTAAGATCTCCATCGCCTTTTTCTCTCTCAGATGTAGAGCAGATTTAAAATGGGCAGAACTGAATGGAGAAAAGCacaatttgttgttgttatttgtggatttttatgtataataaaatattttaatatga
>TCONS_00028392
GGTGAAGTTTATCGTCGGTGCTTTTATACCTGAATTCTCGTTAACGTTAGCAGTATTCGTTATGGTTTTGTCGTTACGAGTCGGTCAATGTCTATGTGAGGCTTTAGTTGCTGTTTTGAGTGAATCTATCATTTCACTTGTTGTTGTTTACGAGTCGGATTGAACCAGTCTGAACAGTTTCGAGTTCGTTTCCGCCACCAAAgACGAAGCAGATGACCTCCCTGAGGTGTTGCCTTCCGGGCCCAGTGCCTTTATTCCAACTGAAGAGATTCTGGAGGAAGGATCCACACATGAAGTGATGTCAGACGTTTTGTTGTCAGAAGGACGTGCTGATCATATCAACATGGTGATGGGGCTTCATCCCACCTACCTGGCCTGTTTCCAGCGCACACAGGATGCTTTGCTCCAGCTGGACGGCCCACTGCCCTTATCATGGAGACATTATATAGTCATTTTGGCGGCTGCTCGTCATCAGTGCTCGTATCTCGTGCAGCATCACAGCTCCGCTTTTCTGCTTGCCGGTGGAGACGAGTCCTGGCTGCGGGGAGTTCACTGTGCACCACCGAAAATACAGCATCTGCAGACACTCAACAAACTGCTGGCACACAGACCCTGGATCATCACCCAGGAGCACATACAGGAGTTAGTTTGTCCCGGTGCGGAGGCTCGATGGTCTCTTGCGGAGCTGATTCAGGCGGTGGTTTTGATGACACACGCTCACTCTCTGGCCTCGTTTGTCTGGGGTTGCGGGATTCATCCAGAGCCTGAGCAGACAGAAGATCAGACGCTTCAGCCGTGTTCGCCCACAGACTCCTGTTGTTCAGTGCGGGGCAAGG

Function

symbol description
sesn2 Predicted to enable leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Predicted to be involved in several processes, including cellular response to leucine; cellular response to leucine starvation; and negative regulation of TORC1 signaling. Predicted to act upstream of or within regulation of response to reactive oxygen species. Predicted to be located in cytoplasm and nucleus. Orthologous to human SESN2 (sestrin 2).

GO:

id name namespace
GO:1901031 regulation of response to reactive oxygen species biological_process
GO:1904262 negative regulation of TORC1 signaling biological_process
GO:0016239 positive regulation of macroautophagy biological_process
GO:1990253 cellular response to leucine starvation biological_process
GO:0071230 cellular response to amino acid stimulus biological_process
GO:0071233 cellular response to leucine biological_process
GO:0061700 GATOR2 complex cellular_component
GO:0005634 nucleus cellular_component
GO:0031932 TORC2 complex cellular_component
GO:0005737 cytoplasm cellular_component
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor molecular_function
GO:0070728 leucine binding molecular_function

KEGG:

id description
ko04150 mTOR signaling pathway
ko04115 p53 signaling pathway
ko04211 Longevity regulating pathway

ZFIN:

id description
ZDB-GENE-070108-1 Predicted to enable leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Predicted to be involved in several processes, including cellular response to leucine; cellular response to leucine starvation; and negative regulation of TORC1 signaling. Predicted to act upstream of or within regulation of response to reactive oxygen species. Predicted to be located in cytoplasm and nucleus. Orthologous to human SESN2 (sestrin 2).

Ensembl:

ensembl_id ENSDARG00000070012

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00028390 False 877 mRNA 0.55 6 43341115 43350352
TCONS_00028391 False 1931 mRNA 0.48 10 43341176 43357457
TCONS_00028392 True 836 mRNA 0.51 5 43341424 43349581

Neighbor

gene id symbol gene type direction distance location
XLOC_014285 matn1 coding upstream 2835 43314700 ~ 43338280 (+)
XLOC_014284 laptm5 coding upstream 31519 43297546 ~ 43309596 (+)
XLOC_014283 DGKD coding upstream 68783 43256986 ~ 43272332 (+)
XLOC_014282 NA coding upstream 89921 43250553 ~ 43251194 (+)
XLOC_014281 eef1a1l1 coding upstream 203375 43119014 ~ 43137740 (+)
XLOC_014287 yrk coding downstream 1618 43359075 ~ 43432415 (+)
XLOC_014288 ahdc1 coding downstream 81944 43439401 ~ 43500299 (+)
XLOC_014289 BX649384.3 coding downstream 147023 43504480 ~ 43515396 (+)
XLOC_014290 wasf2 coding downstream 166233 43523690 ~ 43543128 (+)
XLOC_014291 NA coding downstream 189190 43546647 ~ 43549011 (+)
XLOC_014280 CU207343.3 non-coding upstream 260055 43080925 ~ 43081060 (+)
XLOC_014279 CU207343.4 non-coding upstream 263236 43077744 ~ 43077879 (+)
XLOC_014274 dre-mir-128-2 non-coding upstream 425574 42915419 ~ 42915541 (+)
XLOC_014267 NA non-coding upstream 767988 42565358 ~ 42573127 (+)
XLOC_014295 CR356238.1 non-coding downstream 307934 43665391 ~ 43665511 (+)
XLOC_014300 NA non-coding downstream 429546 43787003 ~ 43791576 (+)
XLOC_014301 NA non-coding downstream 429685 43787142 ~ 43790716 (+)
XLOC_014302 NA non-coding downstream 443375 43800832 ~ 43804410 (+)

Expression


Co-expression Network