Gene
RNA
| Item | Value |
|---|---|
| gene id | XLOC_014675 |
| gene name | thrb |
| gene type | coding |
| species | zebrafish (Danio rerio) |
| category of species | model fish |
| Item | Value |
|---|---|
| chromosome id | NC_007130.7 |
| NCBI id | CM002903.2 |
| chromosome length | 48449771 |
| location | 17514631 ~ 17658253 (-) |
| genome version | GRCz11_2017_zebrafish_Genome |
| symbol | description |
|---|---|
| thrb | Enables nuclear receptor activity. Acts upstream of or within regulation of transcription, DNA-templated; sensory organ development; and thyroid hormone mediated signaling pathway. Predicted to be located in nucleus. Is expressed in several structures, including brain; eye; heart; liver; and optic vesicle. Used to study thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cervix uteri carcinoma in situ; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta). |
| id | name | namespace |
|---|---|---|
| GO:0046549 | retinal cone cell development | biological_process |
| GO:0006355 | regulation of transcription, DNA-templated | biological_process |
| GO:0043010 | camera-type eye development | biological_process |
| GO:0030154 | cell differentiation | biological_process |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | biological_process |
| GO:0048839 | inner ear development | biological_process |
| GO:0002154 | thyroid hormone mediated signaling pathway | biological_process |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | biological_process |
| GO:0009755 | hormone-mediated signaling pathway | biological_process |
| GO:0042671 | retinal cone cell fate determination | biological_process |
| GO:0005634 | nucleus | cellular_component |
| GO:0043565 | sequence-specific DNA binding | molecular_function |
| GO:0005515 | protein binding | molecular_function |
| GO:0046872 | metal ion binding | molecular_function |
| GO:0003677 | DNA binding | molecular_function |
| GO:0070324 | thyroid hormone binding | molecular_function |
| GO:0004879 | nuclear receptor activity | molecular_function |
| GO:0003700 | DNA-binding transcription factor activity | molecular_function |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | molecular_function |
| GO:0003707 | steroid hormone receptor activity | molecular_function |
| GO:0008270 | zinc ion binding | molecular_function |
| id | description |
|---|---|
| ko00260 | Glycine, serine and threonine metabolism |
| ko04080 | Neuroactive ligand-receptor interaction |
| ko04919 | Thyroid hormone signaling pathway |
| ko03000 | Transcription factors |
| ko03310 | Nuclear receptors |
| id | description |
|---|---|
| ZDB-GENE-990415-268 | Enables nuclear receptor activity. Acts upstream of or within regulation of transcription, DNA-templated; sensory organ development; and thyroid hormone mediated signaling pathway. Predicted to be located in nucleus. Is expressed in several structures, including brain; eye; heart; liver; and optic vesicle. Used to study thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cervix uteri carcinoma in situ; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta). |
| ensembl_id | ENSDARG00000021163 |
| RNA id | representative | length | rna type | GC content | exon number | start site | end site |
|---|---|---|---|---|---|---|---|
| TCONS_00028982 | False | 5629 | mRNA | 0.37 | 8 | 17514631 | 17526735 |
| TCONS_00028986 | False | 5804 | mRNA | 0.37 | 11 | 17514631 | 17658253 |
| TCONS_00028987 | False | 5795 | mRNA | 0.37 | 10 | 17514631 | 17658253 |
| TCONS_00028985 | False | 5822 | mRNA | 0.37 | 11 | 17514631 | 17658253 |
| TCONS_00028984 | False | 5732 | mRNA | 0.37 | 9 | 17514631 | 17658253 |
| TCONS_00028983 | False | 5600 | mRNA | 0.37 | 10 | 17514631 | 17658253 |
| TCONS_00028988 | False | 3136 | mRNA | 0.40 | 13 | 17517137 | 17658160 |
| TCONS_00028990 | False | 2198 | mRNA | 0.45 | 12 | 17518061 | 17658173 |
| TCONS_00028989 | False | 1992 | nonsense_mediated_decay | 0.44 | 11 | 17518061 | 17658173 |
| TCONS_00028991 | True | 1234 | processed_transcript | 0.50 | 6 | 17518733 | 17526735 |
| gene id | symbol | gene type | direction | distance | location |
|---|---|---|---|---|---|
| XLOC_014674 | nkiras1 | coding | downstream | 129083 | 17377346 ~ 17385548 (-) |
| XLOC_014673 | NA | coding | downstream | 159898 | 17353644 ~ 17354733 (-) |
| XLOC_014672 | NA | coding | downstream | 185578 | 17322000 ~ 17329053 (-) |
| XLOC_014671 | NA | coding | downstream | 192751 | 17321542 ~ 17321880 (-) |
| XLOC_014670 | sf3a3 | coding | downstream | 209636 | 17288529 ~ 17304995 (-) |
| XLOC_014676 | top2b | coding | upstream | 30097 | 17688350 ~ 17774884 (-) |
| XLOC_014677 | CR391921.1 | coding | upstream | 175951 | 17834204 ~ 17996336 (-) |
| XLOC_014678 | snx10a | coding | upstream | 460068 | 18118321 ~ 18130567 (-) |
| XLOC_014679 | cbx3a | coding | upstream | 473259 | 18131512 ~ 18136410 (-) |
| XLOC_014680 | NA | coding | upstream | 479461 | 18137714 ~ 18139894 (-) |
| XLOC_014711 | CR382300.3 | misc | upstream | 2070437 | 19728690 ~ 19728755 (-) |
| XLOC_014669 | NA | non-coding | downstream | 236824 | 17275458 ~ 17277807 (-) |
| XLOC_014668 | NA | non-coding | downstream | 283611 | 17224646 ~ 17231020 (-) |
| XLOC_014683 | BX649471.3 | non-coding | upstream | 656075 | 18314328 ~ 18315321 (-) |
| XLOC_014684 | BX649471.2 | non-coding | upstream | 705064 | 18363317 ~ 18364965 (-) |
| XLOC_014687 | BX927404.1 | non-coding | upstream | 826453 | 18484706 ~ 18485881 (-) |
| species | gene id | symbol | gene type | chromosome | NCBI id | location |
|---|---|---|---|---|---|---|
| bowfin (Amia calva) | AMCG00014730 | NA | coding | CM030128.1 | CM030128.1 | 28930365 ~ 28951352 (-) |
