XLOC_015405 (aire)


Basic Information

Item Value
gene id XLOC_015405
gene name aire
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007113.7
NCBI id CM002886.2
chromosome length 59640629
location 22808946 ~ 22846553 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00030838
ATGTCTAAGGTGGAGAGTTTTGAAGAGTCTGACCTGCGCTCACAGCTTCGAGCTTGTCGCACTGAGATCGCGATGGCAATTCATGACCCTTTCCCACTGCTGTATGGACTGGCAGATCACAACGTCATCTCAGAACAGATCCTGAGGGAGACTTTAGAGCGAAAGAAAAAGGACGGGATCCACAAAGCCATCTACTCGCTGCTCACTTTGCTGCTGGATCAGGATACTACGGTCCTTAAGGCCTTCTGGAAGAATCTCTGTAAAGAGTACAACAAGGAGTGTTATCCTAAACTGGAAACAGTGTTTATGAACCTTCCCAAAGGTTTAAAGCAGGAGGTCAGACAAAATGGGAACCCCAAGCTTGAGCTGCAGGCCCGCAGTCAGTCCGGCAAGAAGAGAGGGGTGTCTGAAAAACAGCTGACCCACAGGACACATCACCACCACAGCAAGAAATCCTTAACATCCAGCTCTGGAAGCAAAGGCAAGCTGATGAAGAAGACAGATGGAGCAGCACATTCTCAGGTCTCAGTGGGAAATGGAGTCCAAGCAGTTTCCACCTCAGTCCAGAGGGCTGTGACGGTATCTGCAGGTGATCTTCCTGATAGCTGCGGTACAGTGGAGGAGATTCTCATCCAGCAAGTCATTGAGTCTGGAGGAGCCAAAAAATGCATCAAGGTTGGAGGAGAATTCTACTCTTCTGGCAAACTGGATGAGACAGCTGGAGCACAGCAGACGCAGACGCAGACTGCACACACCTCCAGTCACCAGCAGAGAGAGCCAAGCAGCAGAGggttggccacccctggcctacAGTATGTTGTTGCAGTGTTAACCTGCTAccctcaaaaaatgacatttgctGTAGAGCACAATGATGATGAGTGTGCAGTGTGTAAAGACGGCGGCGAGCTCATCTGCTGTGATGGGTGTCCTCGTGCCTTTCATCTCTCCTGTCTGGTGCCCCCCCTCACCTCCATACCCAGgggtACATGGCGCTGTCAGCTTTGCCAAAGCAACAGATTGAAAGACAGGACATACACACATGTGCAGCCTCCAGCAACAGAGACGAGCTCTGGCTCTGCAGTGGATTTCTCCTTCTTCTCCTCTCTGTCCTCTACTTCACTCTCCACAGTCTCAGCGAGCAGCAGCGCTCAATCCATGGGCCTCCAGTCTTCAGATGGTGAAAGAGTTGGGATCAGGATGGCATGTGGCATCTGCTATCTCACCCGGGGAGAGCTGATCACCTGCCCTCAGTGCCTGCAGGCTTATCACGCCCTCTGCAACTTCCCAAATGGAAGGACAAGATGTAGGAATTGCTCCAGATCTTGGGGCCCTGGAAATGACAATTCATCTACGTGTAGGAGTCTTCAGttgAGTCAACATATGAGTGATCAGGGCTTAACGCCATCAGAGCAGCTGCTCAACAGAGACGAGATGGACTCAGTGATGGGGGAGAGCTCTATTGATGGGATCCTGCAGTGGGCTTTCCACAATATTTCACGTCCTCTTTCTGAGACCCAAGGCTATTTCCAATGAAGTTCACCGATTCATCTCTGCTGCGCCTCAGATGTCAGTATCAGGTTCATTCTCAGTTTTAGATGGACTGTCTTTAAGAATAGAAAACCTTTATCATTTGAAGAAAATGAATGTACTGGTTTATCCATTTCTTTTTTCAgagttacatttgttttattgttgtacaGTCCAGATCTCAAAAGGTTGTTGCTACTAtgtgtttgctaattattttttgaaCTCAAACTAATTTTCAagctaaattaaacaaataatgttca
>TCONS_00030839
CAAGATGTAGGAATTGCTCCAGATCTTGGGGCCCTGGAAATGACAATTCATCTACGTGTAGGAGTCTTCAGttgAGTCAACATATGAGTGATCAGGGCTTAACGCCATCAGAGCAGCTGCTCAACAGAGACGAGATGGACTCAGTGATGGGGGAGATAAAGTGGCCTGGAGCAGAATGGGCCCGTGAACAACCCAGTCCATTGAAGGCCGTCTCATGCTTCAATCGCATCTTAAATCACAAATGTGCCATGAAAATATTCCAGGCCAGTAGCAGCCAATAAAGGCTGAATTGTGATGAGTATAGAGCATCCTCTCTAGTGCTGCATACCAACAGCCTGCTTTGCACGACCCAGACAACCACATCTGATCCCTGTGGTGCTGAGTTTAACTTTCTTCTTTCACTCGTCTTCTTTTCCAAGTCTTGTGATTTCTCTAAAAAATCCCACATGGTGCTTTATAACTGTGAGATATCAGGACAAATGCTGAAGGAATGGAGATATTCCAGTTTGGCTCCTCGATAGGGCTGTTGGGGGAAAACAAAGCGAATACAAGACTGAATGTCAAATATAAACGTGCTTTGAAGTCTTGCCATTGGCTTCCAGGAATGACTTTAAGGAAGAGTTTTGACTGATTTGCACAGACTTGTCGTTGAGTACTTCCTTTAC

Function

symbol description
aire Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and histone binding activity. Predicted to be involved in several processes, including immune system development; positive regulation of transcription by RNA polymerase II; and regulation of thymocyte migration. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator).

GO:

id name namespace
GO:0002509 central tolerance induction to self antigen biological_process
GO:2000410 regulation of thymocyte migration biological_process
GO:0032602 chemokine production biological_process
GO:0006959 humoral immune response biological_process
GO:0002458 peripheral T cell tolerance induction biological_process
GO:0045944 positive regulation of transcription by RNA polymerase II biological_process
GO:0097536 thymus epithelium morphogenesis biological_process
GO:0045060 negative thymic T cell selection biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0042393 histone binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0045182 translation regulator activity molecular_function
GO:0003677 DNA binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0000976 transcription regulatory region sequence-specific DNA binding molecular_function
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding molecular_function

KEGG:

id description
ko04120 Ubiquitin mediated proteolysis
ko05340 Primary immunodeficiency
ko03000 Transcription factors
ko04121 Ubiquitin system

ZFIN:

id description
ZDB-GENE-071008-4 Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and histone binding activity. Predicted to be involved in several processes, including immune system development; positive regulation of transcription by RNA polymerase II; and regulation of thymocyte migration. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator).

Ensembl:

ensembl_id ENSDARG00000056784

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00030838 False 1796 mRNA 0.48 14 22808946 22826153
TCONS_00030839 True 665 mRNA 0.45 3 22823952 22846553

Neighbor

gene id symbol gene type direction distance location
XLOC_015404 rab6bb coding upstream 5281 22795494 ~ 22803665 (+)
XLOC_015403 espnlb coding upstream 16486 22765492 ~ 22792460 (+)
XLOC_015402 kif1ab coding upstream 50356 22694382 ~ 22758590 (+)
XLOC_015401 zgc:161973 coding upstream 131927 22659787 ~ 22677019 (+)
XLOC_015400 bokb coding upstream 158511 22640215 ~ 22650435 (+)
XLOC_015406 amotl2b coding downstream 5279 22851832 ~ 22861178 (+)
XLOC_015407 NA coding downstream 64639 22911192 ~ 22916384 (+)
XLOC_015408 NA coding downstream 138577 22985130 ~ 22992029 (+)
XLOC_015409 mknk2a coding downstream 160239 23006792 ~ 23024952 (+)
XLOC_015410 NA coding downstream 178768 23025321 ~ 23026978 (+)
XLOC_015392 CT956055.1 non-coding upstream 837537 21882881 ~ 21971409 (+)
XLOC_015388 NA non-coding upstream 1271674 21534038 ~ 21537272 (+)
XLOC_015385 NA non-coding upstream 1372545 21431725 ~ 21436401 (+)
XLOC_015384 dre-mir-26a-2 non-coding upstream 1433352 21375467 ~ 21375594 (+)
XLOC_015372 rxrga non-coding upstream 2032105 20725684 ~ 20776841 (+)
XLOC_015414 NA non-coding downstream 309459 23156012 ~ 23184804 (+)
XLOC_015416 BX548024.3 non-coding downstream 411224 23257777 ~ 23257897 (+)

Expression


Co-expression Network