XLOC_015747 (mmp14b)


Basic Information

Item Value
gene id XLOC_015747
gene name mmp14b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007113.7
NCBI id CM002886.2
chromosome length 59640629
location 38161318 ~ 38183641 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00031348
AGGGGTTGCTGTGCATGAGAAGCCGAAGATTTTATTAAACTAGAAAAATAAGACAAAGATATATTTGCCAATGATAGCTTGTCTGTTTTTACAATGCGTTCTGTCGATGCTCCATTCTAGCGCCCAGTGCATGAAACGATGACTTTTAGACTGTAGAGTTTCAGTCCGTGCAATGCAACGGTAATATATCGCaggtattgtttacattttgatAAACGTCTGTATTCTCCCGCTTTTCTGGAGAAACCAAAGTTCTCGTCCAATTTGTACCACTATTGTGGTAGGCACTAGTTTTTAAAGCGTTTTTTATTTCGACAGTAACAAAGTGGTGTCAAACTTTATCACGAGTACTTTTTCAACAAAGGAATCAGAGCGAAAAATGATCTGGAGCGGGTTCACGAGGCTGTTGCTCCTAATATTTGTGTGCGCGCACAGATCGTCCTCGAAACAAGATATGAAACCTGAGGCATGGCTACAGCAGTATGGTTACTTGCCCCCTGGTGATTTGCGCACACATACGGCCCGCTCTCCTCAGTCCGTACCCTCTGCCATTGCTGCCATGCAGAGATTCTACGGCCTGACAGTCACTGGCAATTTGGATGCCAATACTCTAGAGGCAATGAAGAGGCCCCGCTGTGGCGTCCCAGACAAGTTTGGATCCGAACTGAAGAGCAACCTGAGAAAGAAGCGCTACGCCATCCAGGGACTGAAATGGGACAAAAATGAGATCACATTCTGCATACAGAACTACACGCCAAAGGTTGGGGAATACGAGACATTTGAGGCCATCAGAAAAGCCTTCAAAGTGTGGGAAAGCGTTACGCCTTTGCGATTCAGAGAGATCTCTTATAGTGACATCAGGGACAAGGTTGTAGACTTTGCAGACATCATGCTCTTCTTCGCTGATGGCTTTCATGGCGATGCCAGTCCATTTGATGGAGAAGGAGGTTTCTTGGCCCATGCTTACTTCCCAGGGAATGGCATAGGAGGGGATACGCACTTTGACGCAGCTGAGCCTTGGACTATTGGCAACAAAGACTTGCTGGGTAATGATGTGTTCCTGGTGGCTGTGCATGAACTGGGCCATGCTTTGGGAATGGAGCATTCAAACGACCCATCCGCCATCATGGCTCCCTTCTACCAGTGGATGGAAACCGACCACTTTGTGCTTCCTGATGATGACCGGAAAGGCATTCAGAAGCTTTATGGACCAGGATCTGGAGGACACCCTCGAACCCCTGTCACCCCTGAGACGCCCCATCACACTCCATACCCCACACCGTACAGGCCAGGAGGACCCTCCTATGGTCCCAACATCTGCGAGGGTCATTTTGACACCATTGGCATTTTCAGAGGAGAAATGTTTGTGTTTAAGGGTAAGTGGTTCTGGCGTGTTCGAAATAATCAAGTTATGGAAAACTACCCCATGCCAATTGGACACTTCTGGAGAGGTCTGCCTACTGACATTAATGCTGCATATGAAAGAGAAGATGGCAAATTTGTCTTCTTTAAAGGGGACAGGCATTGGGTGTTCACTGAGTCCAACTTAGAGCCAGGATACCCGAAGGTTTTAGGAGAACTGGGATCTGGTGTACCAAAGGACAAACTGGATGCAGCTCTTCTCTACACGCCTACAGGCTACACTTACTTCTTCAGAGGAAACAAATATTATCGTTACAATGAAGACACGCACTCAGTGGATCCAGATTATCCCAAACCCATTAGTAAATGGCAAGGCGTTCCAGACAACATAAAGGCTGCATTCATGAGTCGAGATCAAGGTTATACCTACTTCTACAAAGCCAACAAGTACTGGAAGTTTAACAACCAGTTATTGAAAGTGGAGCCTGGATACCCCAAATCAGCACTTAAGGATTGGATGGGCTGCCCTAACGAAGACTCCAATACAGGTGGTGGAGGAAGTGACCGAGACCGGGAACGTGAGAGAGAACGTGAGCGTGAAAGGGAGCGAGAGAGGGAGCGCGCACGAGAGCGTGAACGTGAACAAGACCGCACAAATGAGGTGGACAAGACTGAGGAAGAGGGCAAAAAGGAGGAGACAGAAGTGCTCATAATCGAGGTTGAAGATGCACCCAGCAGCAGAGGAGGAGCGGCTGCCGTGGTGGTGCCACTCATGCTGTTGGTCTGTGTCATTTTTACACTCGGCGCACTTCTCTTCTTCCGCAGGTACGGCACACCGAGACGCTTGCTCTACTGCCAACGCTCCCTACTGGACAAGGTTTAAATGTTTAAGAAGGGATCACGGGAAAAAAAGGGAAGGGGTGGAGAGAATTGAGAATACAGAAGACGGGGACTTATTAGCGAAGCAACACCAAGGAGCGAAACTCAAGGTTTTCACCCAAAAGgaagacctttttttttgtttactttcgaAATGATGCCACTCAGAATCTCAGCATTTGAATATTGCCTAATTAGTGGTCTTGAATGttttgctttcacacctgtgCCGAGCTCTTCCTGCACGCTGTACAAAGGCATACGGTACTTTCCCCCCCGCCAGCGTCTCTATCACTTCATCTCTCCCCTCTTCTTCTCTCAGCATCTTTCCCTTCTGGTGTAGCCAATGACGCCAGCTCATCGCTGTTTGTTTAACCTCttgtaaatgtcattttaaggttGTGAATGTTTTTGTATGTCCGACTTATTGTGAACTCTTACCCTCTGTCAAAACAGAAGCCAGATCAGAAGACTTTGTATTTACTCAGGTTGCAGCTGAAGCACATTTCCAGCAGCCTCATGCAACCTTAAAGTGCCCATATTATGCTATTTCAAGGTCTACAACAGTAATTGAATATGCCCGTGACACTAAAACGCGTTCATATTCCTATTATTGGTCAAAAATGGATTTACTATGTCTGAATTTAAGATCAGTGAGTGTAAATGGTGTCAGTTCAACCATATCAATTCAAACCAGAGTCCAACCATGAAAATTCAATGGAACTAGTTGATCAGCCCAAGCCACCATCACAACTATAATTTGAGTTTAGAAATTGCTAATACTCGACATATTGTCGATTACACAAACCAGCTACAGTGTTTAAGGGACCAGTAGACATTTGTGGACATCCAATGAAGACCATAGGTTGGCATTATAACTAGCGTTTcaaaatcagggtttctgcagctttcattaagtcaaatttaagacttcagACCTTTTTAAGATcagtttgaatacatttttagacttaaatatttaagattaaatggtaaggatttttttctaattgtCTGGTTGGATCAATGGAAAGGATAAGAAAtaactaaattagatttttttaatccacatatttaaaataatgtgtaaataaacatgcattgtttttaacaaaatatttttaaaattaatatagttAAACCATATTGGCCTGATTAGGTAGACATACAAGGAAATAAAGGTATAAAAGGAAAACTAAgatctgtttaaaattatttaatatatacaaaatttaaatgaatttaatacctacaattaaattttttttgagacATTATAAGACTTTGagaccccacagacaccctgAAAATGGACGTCATGCACTTTGAATTTTAAAATGATGCATTACTTTGTAGAAAAGGTGTAATAGGGGCACTTAAATCACAtaccaaacatacaaaaaaattgcAGTGATGGAAAATCTTAAACCATTAAAGCTTGCGTTTAAAAATATTCTTCCATGATGCAAGAACCTTAAGAGGTGGTCAAAAGGTGTTGCATCACCATGGTATTCTCTTTAGTTCCATATAAATGCATGAACATAATCACTTCATACCATGGTATTGCCATCTCTGAACCTTGGTGCTGCCACTTGCGCAGTTACCAAATGCACAAGATGTCATAAAAAATGGTTTGCATTTGTTCATGAATAGTTAATTTTCACAGGGTCCATTCTCACCCCATGCAGCTCCCATCTCAGGTTAAAGAACAAAGTCATGTGCCAAGATAATTGATGATTCTCCACTAACAATGCCTGCAAAGCTGTGCTGTGtttctgcctgtgtgtgtgtgtccttcagTAGTATGGCTTTAtattgtactgtattttaaataattactattattgatAATGATGATGCCgttatcattatgattattactattgttattgttCTCCGTGTCAAGAATgtgttttttattgaaatgtcattaaaaatgtCCTGCTGGACAGGCAATAATGTATGTCTTATGAAGTGGCCTTAATTTAGGAGAAACTGAACGAATGGGTGGGTTTGTAtttttgaaatgaaataaatcttaaaatatgacattttcaCTGCTTGTGTTTACAATTATTGATAACTTGTCGTGCTTTTTTATGGGGATTTTGaagttttcattaaaaacaataatgataataatatttaaatgatgatgatcatCTAAAAATAATTgtgcttgtttcaaaccttttttatgttcaagtcaaaataaactattttgtAAGTTTT

Function

symbol description
mmp14b Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Acts upstream of or within several processes, including gastrulation; intramembranous ossification; and skeletal system development. Predicted to be located in extracellular matrix and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including axis; connective tissue cell; head; myoseptum; and tail bud. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14).

GO:

id name namespace
GO:0042074 cell migration involved in gastrulation biological_process
GO:0001501 skeletal system development biological_process
GO:0051216 cartilage development biological_process
GO:0030198 extracellular matrix organization biological_process
GO:0009948 anterior/posterior axis specification biological_process
GO:0031638 zymogen activation biological_process
GO:0006508 proteolysis biological_process
GO:0030574 collagen catabolic process biological_process
GO:0030010 establishment of cell polarity biological_process
GO:0060026 convergent extension biological_process
GO:0060027 convergent extension involved in gastrulation biological_process
GO:0031012 extracellular matrix cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0046872 metal ion binding molecular_function
GO:0004222 metalloendopeptidase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0008233 peptidase activity molecular_function
GO:0008237 metallopeptidase activity molecular_function
GO:0008270 zinc ion binding molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-030901-2 Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Acts upstream of or within several processes, including gastrulation; intramembranous ossification; and skeletal system development. Predicted to be located in extracellular matrix and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including axis; connective tissue cell; head; myoseptum; and tail bud. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14).

Ensembl:

ensembl_id ENSDARG00000008388

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00031348 True 4473 mRNA 0.41 10 38161318 38183641

Neighbor

gene id symbol gene type direction distance location
XLOC_015746 sall2 coding upstream 3979 38147761 ~ 38157339 (+)
XLOC_015745 si:rp71-1g18.1 coding upstream 95145 38055529 ~ 38066173 (+)
XLOC_015744 casq1a coding upstream 106836 38039857 ~ 38054482 (+)
XLOC_015743 hnrnpc coding upstream 127128 38025260 ~ 38034190 (+)
XLOC_015742 dcaf8 coding upstream 140715 38002717 ~ 38020603 (+)
XLOC_015748 C2H14orf119 coding downstream 41786 38225427 ~ 38230008 (+)
XLOC_015749 dhrs1 coding downstream 78107 38261748 ~ 38269675 (+)
XLOC_015750 homeza coding downstream 87751 38271392 ~ 38275658 (+)
XLOC_015751 NA coding downstream 97341 38280982 ~ 38283096 (+)
XLOC_015752 nedd8l coding downstream 104667 38288308 ~ 38289751 (+)
XLOC_015741 NA non-coding upstream 161124 37999779 ~ 38000194 (+)
XLOC_015740 NA non-coding upstream 170813 37974996 ~ 37990505 (+)
XLOC_015738 NA non-coding upstream 190274 37967985 ~ 37971044 (+)
XLOC_015737 LO017954.1 non-coding upstream 233906 37926380 ~ 37927412 (+)
XLOC_015734 AL954692.1 non-coding upstream 314469 37836619 ~ 37846849 (+)
XLOC_015753 NA non-coding downstream 186894 38370535 ~ 38371944 (+)
XLOC_015755 NA non-coding downstream 232376 38416017 ~ 38422233 (+)
XLOC_015762 AL953896.1 non-coding downstream 852541 39036182 ~ 39046184 (+)
XLOC_015763 NA non-coding downstream 868246 39051887 ~ 39052229 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000004_16037124_16044487 MMP14, MMP14A, MMP14B, MT1-MMP coding CI01000004 null 16037124 ~ 16044563 (+)