XLOC_018104 (esr1)


Basic Information

Item Value
gene id XLOC_018104
gene name esr1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007131.7
NCBI id CM002904.2
chromosome length 55201332
location 26359756 ~ 26383375 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00035676
AGTCAGAGATACATCAGTGAGAGACAGAAAGCATCCAGCCTGTAATGGGACTCAAGTAAAACATCAGAGGAGTGAACATTTTGACCAGCGGAGAGGCTGTTGGTGCCAGGCAGCGACGCAGGACCAGCCCGAGTCCTGAGAGAGAAGCCCTGGAGGAACCTTCCTCGCCACCTGCCGCCCACAAACTCTCACCCATGTACCCTAAGGAGGAGCACAGCGCGGGGGGCATCAGCTCCTCTGTCAACTACCTAGATGGAGCTTATGAGTACCCGAACCCCACACAGACCTTCGGCACCTCGTCGCCTGCAGAGCCTGCTTCAGTGGGATACTACCCGGCTCCCCCAGACCCCCACGAGGAACATCTACAGACGCTTGGCGGTGGATCAAGCAGCCCCCTCATGTTCGCACCCTCCAGCCCACAGCTGTCCCCGTATCTGAGCCATCACGGAGGACACCACACCACCCCTCATCAGGTGTCCTACTACCTGGATTCCTCGTCCAGCACCGTCTACAGGTCCAGTGTGGTGTCCTCTCAGCAGGCAGCCGTGGGCCTGTGTGAGGAGCTGTGCAGTGCCACTGACAGGCAGGAGTTGTACACTGGATCCAGAGCGGCTGGAGGCTTTGATTCAGGGAAAGAGACTCGCTTCTGTGCGGTGTGCAGTGACTACGCCTCTGGATATCATTACGGAGTCTGGTCGTGTGAGGGATGCAAAGCTTTCTTCAAGAGAAGCATTCAAGGTCACAATGACTATGTTTGTCCAGCGACCAACCAGTGCACTATTGACAGAAACCGTCGAAAGAGCTGCCAAGCATGCAGACTGCGCAAGTGTTATGAAGTAGGCATGATGAAAGGagGTATTCGTAAAGATCGCGGCGGGCGTTCTGTCAGGCGTGAGAGAAGAAGAAGCAGTAATGAAGATCGAGACAAGAGCACCAGTGATCAGTGCAGCCGTGCTGGCGTGAGGACGACTGGCCCACAGGACAAGAGGAAGAAGCGCAGTGGTGGGGTGGTCAGCACTTTATGCATGTCGCCTGACcaggtgctgctgctgctgctgggggCTGAGCCACCCGCTGTCTGCTCACGACAGAAACACAGCCGGCCCTACACCGAGATCACCATGATGTCCCTGCTCACCAACATGGCTGACAAAGAACTCGTCCACATGATCGCCTGGGCCAAGAAAGTGCCAGGATTCCAGGATCTGTCTCTGCATGACCAGGTTCAGTTGTTGGAGAGCTCTTGGCTGGAGGTGTTGATGATTGGCCTCATATGGAGGTCCATTCATTCCCCTGGAAAACTCATCTTTGCTCAAGATCTCATCCTGGATAGGAGTGAAGGAGAATGTGTTGAGGGCATGGCTGAGATTTTCGACATGCTCTTGGCAACTGTGGCTCGATTTCGGAGTCTCAAGCTCAAGCTGGAGGAATTTGTGTGTCTCAAAGCCATCATACTCATCAATTCTGGTGCATTTTCATTCTGCTCCAGTCCAGTGGAGCCGCTGATGGACAACTTCATGGTGCAGTGCATGCTGGACAACATCACTGATGCCCTCATTTACTGCATCAGTAAATCAGGAGCGTCGCTGCAGCTGCAGTCCCGTCGCCAGGCCCAGCTCCTGCTGCTGCTCTCACACATCAGACACATGAGCAACAAAGGAATGGAGCACTTATACCGAATGAAATGTAAGAATCGAGTGCCGCTGTATGACCTGTTGCTGGAGATGCTGGACGCTCAGCGGTTCCAGTCTTCAGGGAAGGTGCAGCGAGTGTGGTCTCAGAGCGAGAAAAACCCTCCATCCACACCCAcaaccagcagcagcagcagcaacaacagtcCAAGAGGAGGAGCTGCAGCCATTCAGTCCAACGGCGCCTGTCACAGCCATAGCCCTGACCCCTGACCTGTGCACTGCCACcatatacacattatacacaATTTGAAGAGCAGAAATGAGGACTAGGACTTCAGTCTCTTCTTGTGCCTTACGAGAGTCTACTATTGAAACCGAGACATTCGAAAGAGAATTTGTTTATAGAAAAAAAAGTCTGTAAATAAGAATAAGCCTCCCAAACACTATATATTGAGGATCTATTTACGGTTGATTTCGCTCGGTTTTTGTGGAAGCTGATTACAGGAATTTGTTTTTCCCATACACttgagagaaacagagagagatgcTAATTCATCTTTTATTCTTTTACAATTTGTGACCGTTTGACATCACAAACTCACTTAAAGCTCTCATACTGATCATATGGCAGTCAAAAAATACTGATTTAATtttcaataaattaatatattataatagtatattagtgttaaaatagtattttgtatttttagagTATTTTATTGTCATAAATAATGTTAATGCAATAGTAATTATCCATTTATGACCAGATATTACAAAGTTTTAAGAAACAGATCTGAAAATGAAATTTCCAACTTTTAAATGTTGAATGCAGAAATGAAAAAGTTCCACATCCACACAGTAGGCTACcaaaaaacaagtaaattaaGTTTAAACGCTGCTCTGATTTCCTCATCTACATTCTTTATAGTATAGCTTATGTTTGcattgcaaaaaaagaaaaaaaaagaatgaatgaagggataattgtttttttaactaCTCAAGTTCTTCTAGTTGATGCATGTGCCAACTTTTtcttgccaatcttaagccaattgtaatgtTTCGTTTTTagttcaatttggaatttccaCAACTTTGGCAGAGATCGGGGGATCAGAGTGAGCGCTCCTACTTGGCCCCACCCTGATCAAGAAAGGCATAAATTAAAGCGCTCTGACTGAATTTTATGATTGGTCCAGTATTATTACTGACAtgcttaaatattttttgtttgttttttgcttttacttatttttattgaattcttaatttgttaaaatattagcctgttttgcttttctttctttttttttttttaaagatcctGTTTACACACAATTCCCTAAACAGATTACGGACGTTGCTATTAAATGACAGTTTTTCATGTTAATAAGCTTTTTATCTAAAATAACATGAGCTCTGCGATATAAAGTGTGAACAGACAGAAAACAGCCCAGGAGAAAAGTTACTCTTAGAACAAACGGGGAAAAACCTGATTACTTGTAAAAGGGGCTTTATGTTAATGAAGTGAGTCTTTTCATTGCAATCAGGGATATATTATGGATCTAAATCCCTCTTCTATTTTAAACGTTGATATGTAATTTAATGGGGAAAAACTGCTCAGTGATCAGTGGTAACATTATAGCTGCATCTTATTTGTGCAAAAATGTTTACTTGTTGGTTAATatgaaatgatttttttaattgcTGTTCTTGTTACAGTGCTGTCTGTcattgttgattttattgctaTCTTAACAGATTACTGCTTGAAAAGAAAGCCCAATTTCAACATTGTGAAGGTCTGAA
>TCONS_00035677
ACCAGCCCGAGTCCTGAGAGAGAAGCCCTGGAGGAACCTTCCTCGCCACCTGCCGCCCACAAACTCTCACCCATGTACCCTAAGGAGGAGCACAGCGCGGGGGGCATCAGCTCCTCTGTCAACTACCTAGATGGAGCTTATGAGTACCCGAACCCCACACAGACCTTCGGCACCTCGTCGCCTGCAGAGCCTGCTTCAGTGGGATACTACCCGGCTCCCCCAGACCCCCACGAGGAACATCTACAGACGCTTGGCGGTGGATCAAGCAGCCCCCTCATGTTCGCACCCTCCAGCCCACAGCTGTCCCCGTATCTGAGCCATCACGGAGGACACCACACCACCCCTCATCAGGTGTCCTACTACCTGGATTCCTCGTCCAGCACCGTCTACAGGTCCAGTGTGGTGTCCTCTCAGCAGGCAGCCGTGGGCCTGTGTGAGGAGCTGTGCAGTGCCACTGACAGGCAGGAGTTGTACACTGGATCCAGAGCGGCTGGAGGCTTTGATTCAGGGAAAGAGACTCGCTTCTGTGCGGTGTGCAGTGACTACGCCTCTGGATATCATTACGGAGTCTGGTCGTGTGAGGGATGCAAAGCTTTCTTCAAGAGAAGCATTCAAGGTCACAATGACTATGTTTGTCCAGCGACCAACCAGTGCACTATTGACAGAAACCGTCGAAAGAGCTGCCAAGCATGCAGACTGCGCAAGTGTTATGAAGTAGGCATGATGAAAGGagGTATTCGTAAAGATCGCGGCGGGCGTTCTGTCAGGCGTGAGAGAAGAAGAAGCAGTAATGAAGATCGAGACAAGAGCACCAGTGATCAGTGCAGCCGTGCTGGCGTGAGGACGACTGGCCCACAGGACAAGAGGAAGAAGCGCAGTGGTGGGGTGGTCAGCACTTTATGCATGTCGCCTGACcaggtgctgctgctgctgctgggggCTGAGCCACCCGCTGTCTGCTCACGACAGAAACACAGCCGGCCCTACACCGAGATCACCATGATGTCCCTGCTCACCAACATGGCTGACAAAGAACTCGTCCACATGATCGCCTGGGCCAAGAAAGTGCCAGGATTCCAGGATCTGTCTCTGCATGACCAGGTTCAGTTGTTGGAGAGCTCTTGGCTGGAGGTGTTGATGATTGGCCTCATATGGAGGTCCATTCATTCCCCTGGAAAACTCATCTTTGCTCAAGATCTCATCCTGGATAGGAGTGAAGGAGAATGTGTTGAGGGCATGGCTGAGATTTTCGACATGCTCTTGGCAACTGTGGCTCGATTTCGGAGTCTCAAGCTCAAGCTGGAGGAATTTGTGTGTCTCAAAGCCATCATACTCATCAATTCTGGTGCATTTTCATTCTGCTCCAGTCCAGTGGAGCCGCTGATGGACAACTTCATGGTGCAGTGCATGCTGGACAACATCACTGATGCCCTCATTTACTGCATCAGTAAATCAGGAGCGTCGCTGCAGCTGCAGTCCCGTCGCCAGGCCCAGCTCCTGCTGCTGCTCTCACACATCAGACACATGAGCAACAAAGGAATGGAGCACTTATACCGAATGAAATGTAAGAATCGAGTGCCGCTGTATGACCTGTTGCTGGAGATGCTGGACGCTCAGCGGTTCCAGTCTTCAGGGAAGGTGCAGCGAGTGTGGTCTCAGAGCGAGAAAAACCCTCCATCCACACCCAcaaccagcagcagcagcagcaacaacagtcCAAGAGGAGGAGCTGCAGCCATTCAGTCCAACGGCGCCTGTCACAGCCATAGCCCTGACCCCTGACCTGTGCACTGCCACcatatacacattatacacaATTTGAAGAGCAGAAATGAGGACTAGGACTTCAGTCTCTTCTTGTGCCTTACGAGAGTCTACTATTGAAACCGAGACATTCGAAAGAGAATTTGTTTATAGAAAAAAAAGTCTGTAAATAAGAATAAGCCTCCCAAACACTATATATTGAGGATCTATTTACGGTTGATTTCGCTCGGTT
>TCONS_00035678
GATACATCAGTGAGAGACAGAAAGCATCCAGCCTGTAATGGGACTCAAGTAAAACATCAGAGGAGTGAACATTTTGACCAGCGGAGAGGCTGTTGGTGCCAGGCAGCGACGCAGGACCAGCCCGAGTCCTGAGAGAGAAGCCCTGGAGGAACCTTCCTCGCCACCTGCCGCCCACAAACTCTCACCCATGTACCCTAAGGAGGAGCACAGCGCGGGGGGCATCAGCTCCTCTGTCAACTACCTAGATGGAGCTTATGAGTACCCGAACCCCACACAGACCTTCGGCACCTCGTCGCCTGCAGAGCCTGCTTCAGTGGGATACTACCCGGCTCCCCCAGACCCCCACGAGGAACATCTACAGACGCTTGGCGGTGGATCAAGCAGCCCCCTCATGTTCGCACCCTCCAGCCCACAGCTGTCCCCGTATCTGAGCCATCACGGAGGACACCACACCACCCCTCATCAGGTGTCCTACTACCTGGATTCCTCGTCCAGCACCGTCTACAGGTCCAGTGTGGTGTCCTCTCAGCAGGCAGCCGTGGGCCTGTGTGAGGAGCTGTGCAGTGCCACTGACAGGCAGGAGTTGTACACTGGATCCAGAGCGGCTGGAGGCTTTGATTCAGGGAAAGAGACTCGCTTCTGTGCGGTGTGCAGTGACTACGCCTCTGGATATCATTACGGAGTCTGGTCGTGTGAGGGATGCAAAGCTTTCTTCAAGAGAAGCATTCAAGGTCACAATGACTATGTTTGTCCAGCGACCAACCAGTGCACTATTGACAGAAACCGTCGAAAGAGCTGCCAAGCATGCAGACTGCGCAAGTGTTATGAAGTAGGCATGATGAAAGGagGTATTCGTAAAGATCGCGGCGGGCGTTCTGTCAGGCGTGAGAGAAGAAGAAGCAGTAATGAAGATCGAGACAAGAGCACCAGTGATCAGTGCAGCCGTGCTGGCGTGAGGACGACTGGCCCACAGGACAAGAGGAAGAAGCGCAGTGGTGGGGTGGTCAGCACTTTATGCATGTCGCCTGACcaggtgctgctgctgctgctgggggCTGAGCCACCCGCTGTCTGCTCACGACAGAAACACAGCCGGCCCTACACCGAGATCACCATGATGTCCCTGCTCACCAACATGGCTGACAAAGAACTCGTCCACATGATCGCCTGGGCCAAGAAAGTGCCAGGATTCCAGGATCTGTCTCTGCATGACCAGGTTCAGTTGTTGGAGAGCTCTTGGCTGGAGGTGTTGATGATTGGCCTCATATGGAGGTCCATTCATTCCCCTGGAAAACTCATCTTTGCTCAAGATCTCATCCTGGATAGGAGTGAAGGAGAATGTGTTGAGGGCATGGCTGAGATTTTCGACATGCTCTTGGCAACTGTGGCTCGATTTCGGAGTCTCAAGCTCAAGCTGGAGGAATTTGTGTGTCTCAAAGCCATCATACTCATCAATTCTGGTGCATTTTCATTCTGCTCCAGTCCAGTGGAGCCGCTGATGGACAACTTCATGGTGCAGTGCATGCTGGACAACATCACTGATGCCCTCATTTACTGCATCAGTAAATCAGGAGCGTCGCTGCAGCTGCAGTCCCGTCGCCAGGCCCAGCTCCTGCTGCTGCTCTCACACATCAGACACATGAGGTACATTGAGAGTCACACACACATAACTAAATTTACACTACTAACATCAGAAACCAGATAAAGGACCATTGAAAAATGTTCagt
>TCONS_00035679
TTTGAGAAAGACTGTGGGAGGTGGAAAAAAAGAAGCCTGAGCTTAAAAAAGACAGAAACAGTCTTTTGCTTATGAACAGATAGTACCCTAAGTCATGCTTCCTGCGTGTGTGTTTCCATGGTGATGTCTGCTCACGACAGAAACACAGCCGGCCCTACACCGAGATCACCATGATGTCCCTGCTCACCAACATGGCTGACAAAGAACTCGTC

Function

symbol description
esr1 Enables estrogen receptor activity; nuclear receptor activity; and steroid binding activity. Acts upstream of or within several processes, including cellular response to estrogen stimulus; posterior lateral line neuromast primordium migration; and response to estradiol. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including diencephalon; head; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1).

GO:

id name namespace
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0032355 response to estradiol biological_process
GO:0043627 response to estrogen biological_process
GO:0071391 cellular response to estrogen stimulus biological_process
GO:0043401 steroid hormone mediated signaling pathway biological_process
GO:0030518 intracellular steroid hormone receptor signaling pathway biological_process
GO:0009410 response to xenobiotic stimulus biological_process
GO:0048920 posterior lateral line neuromast primordium migration biological_process
GO:0005634 nucleus cellular_component
GO:0043565 sequence-specific DNA binding molecular_function
GO:0005496 steroid binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0004879 nuclear receptor activity molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding molecular_function
GO:0003707 steroid hormone receptor activity molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0008289 lipid binding molecular_function
GO:0030284 estrogen receptor activity molecular_function
GO:1990239 steroid hormone binding molecular_function

KEGG:

id description
ko04915 Estrogen signaling pathway
ko04917 Prolactin signaling pathway
ko04919 Thyroid hormone signaling pathway
ko04961 Endocrine and other factor-regulated calcium reabsorption
ko05200 Pathways in cancer
ko05205 Proteoglycans in cancer
ko05207 Chemical carcinogenesis - receptor activation
ko05224 Breast cancer
ko01522 Endocrine resistance
ko03000 Transcription factors
ko03310 Nuclear receptors

ZFIN:

id description
ZDB-GENE-020806-5 Enables estrogen receptor activity; nuclear receptor activity; and steroid binding activity. Acts upstream of or within several processes, including cellular response to estrogen stimulus; posterior lateral line neuromast primordium migration; and response to estradiol. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including diencephalon; head; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1).

Ensembl:

ensembl_id ENSDARG00000004111

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00035676 False 3449 mRNA 0.44 9 26359756 26383375
TCONS_00035677 False 1996 mRNA 0.53 8 26361087 26382284
TCONS_00035678 False 1728 mRNA 0.54 8 26362266 26383368
TCONS_00035679 True 212 mRNA 0.47 2 26368521 26382461

Neighbor

gene id symbol gene type direction distance location
XLOC_018103 BX470119.2 coding downstream 164915 26194726 ~ 26194841 (-)
XLOC_018102 BX470119.1 coding downstream 240297 26119339 ~ 26119459 (-)
XLOC_018101 myct1a coding downstream 288807 26062519 ~ 26070949 (-)
XLOC_018100 serac1 coding downstream 299602 26048304 ~ 26060154 (-)
XLOC_018099 gtf2h5 coding downstream 311969 26045253 ~ 26047787 (-)
XLOC_018105 armt1 coding upstream 3804 26387179 ~ 26391958 (-)
XLOC_018106 akap12b coding upstream 24383 26407758 ~ 26467454 (-)
XLOC_018107 NA coding upstream 62528 26445903 ~ 26458381 (-)
XLOC_018108 mthfd1l coding upstream 94822 26478197 ~ 26532167 (-)
XLOC_018109 stx11b.2 coding upstream 151967 26535342 ~ 26537171 (-)
XLOC_017928 CU539064.1 misc downstream 16306055 10053405 ~ 10053701 (-)
XLOC_018092 CR352243.2 non-coding downstream 647341 25710791 ~ 25712415 (-)
XLOC_018088 BX322665.2 non-coding downstream 754471 25600105 ~ 25605285 (-)
XLOC_018080 NA non-coding downstream 1048302 25307795 ~ 25311454 (-)
XLOC_018112 NA non-coding upstream 247695 26631070 ~ 26708526 (-)
XLOC_018116 BX248515.2 non-coding upstream 576158 26959533 ~ 26962756 (-)
XLOC_018118 BX248515.3 non-coding upstream 670720 27054095 ~ 27054220 (-)
XLOC_018129 NA non-coding upstream 1731389 28114764 ~ 28164152 (-)

Expression


Co-expression Network