cyp17a1 (cyp17a1)


Basic Information

Item Value
gene id cyp17a1
gene name cyp17a1
gene type coding
species rainbow trout (Oncorhynchus mykiss)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_048565.1
NCBI id CM023219.2
chromosome length 95772356
location 68401582 ~ 68404726 (-)
genome version USDA_OmykA_1.1_2020_rainbow_trout_Genome

Sequence

>NM_001124747.1
GTGACACTCTGATAACGACGCCAGCCCCTCTCGGCCCAACATACAGCATGGCGTGGtttttgtgcatgtgtgtattcTCTGTGGTCGGGCTGGGTCTACTGCTCTTGCAGGTGAAACTTCGAAGGTCCCTGGAGACCAGAGGGGGCCCTCCGAGCCTGCCCGTGTTCCCACTCATCGGGAGCCTGTTGAGCCTGCGAAGCAATCAGGCACCGCATGTCCTCTTCCAGAAGCTGCAGCAGAAGTATGGACATACCTATTCTCTAATGATGGGCCCACACACAGTCATCCTTGTCAACCACCACCAGCACGCCAAAGAGGTCCTCCTTAAAAAGGGGAAAATCTTTGCAGGAAGACCCAGAACAGTAACCACAGACCTGTTGACGAGGGACGGTAAAGATATTGCCTTTGCAGACTACGGTGCCACTTGGAGATTTCATCGTAAAACAGTGCATGGAGCCTTGTGTATGTTTGGTGAGGGCTCTGCCTCCATCGAGAAGATTAtctgtaGGGAAGCTCTCTCCCTGTGTGACACTCTGCGAGAGTCAGGAAGTGCATCGTTGGACTTGTCCCCAGAGCTGACAAGAGCTGTCACCAACGTGGTCTGCTCTCTCTGCTTCAGCTCCTCCTATTGCCGCGGCGACCCCGAGTTTGAGGCCATGCTGCAGTTCAGCCAGGGCATCGTGGATACGGTCGCTAAGGACAGTCTGGTGGACATCTTCCCATGGCTACAGGTCTTCCCCAACGCAGACCTGCGTCTCCTAAAGCAGTGTGTGTCAATCAGAGACAAGCTGCTTCAGAAAAAATACGAGGAACACAAGTCGGACTACAGCGATCATGAACAGAGAGACCTGCTGGACGCCCTGCTAAGGGCCAAACGCAGTGCTGAGAACAACAACACTGCCGAGATCACCATGGAGACCGTGGGCCTTAGTGAAGACCACCTGCTCATGACCGTGGGTGACATATTTGGAGCCGGAGTGGAAACCACGTCAACAGTCCTAAAATGGGCAATTGCCTACCTCATCCACCATCCACAGGTACAACAGCGAATTCAGGAGGAACTGGACAGTGTGGTGGGGGGAGACAGAACCCCCCAGCTCAGTGACAGGGGGAGCCTGCCCTACCTGGAGGCCACCATTAGAGAGGTGCTACGCATCCGGCCTGTTGCCCCTCTACTCATCCCCCATGTAGCCCAAACAgacaccagTATTGGCAAGTTCACTGTTAGGAAAGGTGCTCGCATCATCATCAACTTGTGGTCCCTGCATCACGATGAGAAGGAGTGGAAGAACCCAGAGATGTTTGACCCTGGTCGCTTCCTGAACGAGGAGGGGACAGGTCTGTGCATCCCCTCGCCCAGCTACTTGCCGTTTGGGGCAGGGGTGAGAGTGTGTCTGGGAGAGGCGCTGGCTAAGATGGagatcttcctcttcctctcctggaTCCTTCAGCGTTTAACTATGACCGTGTCCCCGGGCCAGCCACTGCCCAGCCTGGAAGGAAAGTTTGGGGTAGTCCTCCAGCCGGTCAAATACAAGGTCAATGCCACACCAAGAGCAGGCTGGGAGAAGAGCCATCTCCAGACCtcttagaccccccccccctccacccttaACGAATGACATGCATGGGTGTTAATGTTTAAACACTAATAGTGGTGCATTTGAATTGACCTTGGAATCTCATAGCTCCAGTTGGTCAAGTTGTGAAGATGATATAAATGCGTTCTAGTGCTTTTGAGGTTGGTACAACTCTACAATGAATTAGATTTTTAGCTAGAGCGCTAAGCAAGATAGTGTTGCTAATAATAAGTTGGTTAACTAGCTGACAATGTGTCAAACCATAGACTGTATTGGTCAAAGTAGCTTCTTTATCCACATAGCTAAAGGCATTGTTTTACCATCTTTTGGTCGCAAAGGTGACAGGTCATTGATGAAACGTCAGAACTCGATGATACTCAGGTATCATCATTCTGGCCTGAGTTTTTCACTTGGAACTTGGAGGGCATTGACTTGGAGGGCATTGTACTGGCTATTTTGGAGTCGGGAACTCGTATTTCCACATTTCAGAGAGCTCTCGAATGCACCATAGAACATGGAAACAGGCGTGAACTAAGGTTGTGATACATTACGCAGAGACAGCCCTTGTAATGACTGCTATTTTTCACTGTATTGATGTTGAACAATGCTGTATATTTTTTTGCCTTAATGAGCTGTACTAATGTATTCCGTTACTACTGTTTTACATAATACTGTCTTTCAGTGATGAATAAAAAATCATATGGCA

Function

symbol description
cyp17a1 Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity; 17-alpha-hydroxyprogesterone aldolase activity; and steroid 17-alpha-monooxygenase activity. Acts upstream of or within with a positive effect on female sex determination. Acts upstream of or within with a negative effect on male sex determination. Acts upstream of or within androst-4-ene-3,17-dione biosynthetic process and progesterone metabolic process. Predicted to be located in membrane. Is expressed in Leydig cell; brain; and gonad. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1).

NR:

description
steroid 17-alpha-hydroxylase/17,20 lyase

GO:

id name namespace
GO:0006694 steroid biosynthetic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0016020 membrane cellular_component
GO:0005506 iron ion binding molecular_function
GO:0004508 steroid 17-alpha-monooxygenase activity molecular_function
GO:0047442 17-alpha-hydroxyprogesterone aldolase activity molecular_function
GO:0020037 heme binding molecular_function

KEGG:

id description
K00512 CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase

RNA

RNA id representative length rna type GC content exon number start site end site
NM_001124747.1 True 2286 mRNA 0.50 7 68401582 68404726

Neighbor

gene id symbol gene type direction distance location
lbx1a LOC105005765 coding downstream 183040 68215999 ~ 68218542 (-)
tlx1 LOC106576912 coding downstream 232625 68162832 ~ 68168957 (-)
sdhaf4 LOC106576700 coding downstream 239558 68157900 ~ 68162024 (-)
LOC110527795 LOC106576701 coding downstream 249566 68142952 ~ 68152016 (-)
LOC110527775 LOC106576703 coding downstream 283893 68104128 ~ 68117689 (-)
nt5c2a nt5c2 coding upstream 4787 68409513 ~ 68433891 (-)
pcgf6 pcgf6 coding upstream 33347 68438073 ~ 68444855 (-)
LOC110527905 LOC106576688 coding upstream 44003 68448729 ~ 68460372 (-)
calhm2.1 calhm2 coding upstream 55374 68460100 ~ 68463774 (-)
LOC118965304 calhm3 coding upstream 59193 68463919 ~ 68465072 (-)
G75854 NA non-coding downstream 21399 68379943 ~ 68380183 (-)
G75852 NA non-coding downstream 23827 68377255 ~ 68377755 (-)
G75848 NA non-coding downstream 28679 68372442 ~ 68372903 (-)
G75846 NA non-coding downstream 30639 68370738 ~ 68370943 (-)
G75764 NA non-coding downstream 115955 68232232 ~ 68285627 (-)
G75916 NA non-coding upstream 30839 68435565 ~ 68437455 (-)
G76134 NA non-coding upstream 148491 68553217 ~ 68553432 (-)
LOC110527939 LOC106576682 non-coding upstream 164208 68555998 ~ 68575122 (-)
LOC110527951 coda1 non-coding upstream 174106 68575379 ~ 68690343 (-)
G76341 NA non-coding upstream 296368 68701094 ~ 68701345 (-)
G75682 NA other downstream 189876 68210180 ~ 68211706 (-)
LOC110527687 sncg other downstream 719852 67669589 ~ 67681775 (-)
LOC110527584 LOC106576720 other downstream 1013538 67386509 ~ 67389299 (-)
LOC110527436 ppp2r5d other downstream 1390995 66965664 ~ 67010646 (-)
LOC118965321 LOC106576963 other upstream 1678114 70082835 ~ 70088715 (-)
G78414 NA other upstream 1950190 70354916 ~ 70355591 (-)
G79616 NA other upstream 2917224 71321950 ~ 71386523 (-)
G79700 NA other upstream 3064956 71469435 ~ 71470755 (-)

Expression


Co-expression Network