XLOC_020303 (lpl)


Basic Information

Item Value
gene id XLOC_020303
gene name lpl
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007133.7
NCBI id CM002906.2
chromosome length 39133080
location 15624371 ~ 15630421 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00040308
GTCAGTGTGGGGGTTCCTGGCTTTTTATTGGTCAGATCGCGCCTTACCCCGCCTCTGTTGACCAATAAAATGCCGCTGATTTGCATAAGGTCCCGCACGGTAGGATAAAGACACGCTTGTAGCGGCACCGATTTAAACTTTTGAGGAACTCTGGACACAAGACATCTAAAGCAGCTGCTGCCTCCCAACTGGAATATTAACCTGCTGTAACACTGTTTAAATACCCGGATCTCAACGCCTTTTACATTCAATCCTAACAAGCTGTTGAATCCGTGATCATTATGATGTTTAATAAGGGGAGAGTAAGCAGCGCTTTTTTAATATCTTGGATGTACTTTGTCTACATTTCCTCGGGAATGGAAACTACAATTGACCCAACTGCTGAATCTATCACTTTAAGTGACATCATAGGCAATGCCACAGAATGGATGATGGATTTCACTGACATCGAGTCCAAGTTTTCTTTTCGGACCCTCGAAGAACCTGAAGATGACCTGTGCTACATAGTTCCTGGTCAACCCCAATCCATCAAAGACTGTAACTTCAATACAGAAACCAAGACTTTTATAGTTATTCATGGATGGACGgtcACGGGAATGTTTGAGAGCTGGGTTCCCAAACTGGTAACAGCTCTTTATGAACGAGAGCCCTCAGCCAATGTTATTGTTGTGGACTGGTTGTCCCGTGCGCAACAACATTACCCAACATCAGCCTCCTACACAAAACTAGTTGGCAAAGACGTGGCCAAATTTGTCAACTGGTTACAGGCTGAAATTGATTATCCTTGGGAGAAGCTGCATCTGTTGGGTTACAGTCTTGGCGCTCATGTTGCAGGAATCGCTGGCCTTCTCACCAAACATAAAGTTAACAGAATCACAGGCATGGATCCTGCTGGCCCGACCTTTGAGTATGCAGATTCCCTAAGCACTCTTTCTCCAGACGACGCCAATTTCGTTGATGTTCTTCACACCAACACCCGTGGTTCTCCAGATCGTAGCATTGGGATTCAGAGGCCGGTGGGACACATAGACATCTACCCCAATGGTGGGACCTTCCAACCTGGCTGTGACCTCCAGAACACGATGTTAATGGTGGCCACTACTGGTTTGAGAAATATGGATCAGATCGTGAAGTGTTCTCACGAGCGCTCTATTCACCTCTTCATTGACTCTCTGGTGAACCAGGACCATGAGAGCATGGCTTTTCGCTGCAGCTCCAGAGACAGCTTTAACAAGGGCATGTGCCTCAGCTGCCGCAAGAACCGCTGCAACAAGGTGGGATACGCAGTTAACAAAATTCGCACACGCAGGAGCAGCAAGATGTACATGAAAACCAGAGAGATGATGCCATATAAAGTTTTCCATTATCAAGTGAAGGTCCACTTCTTTGGAAAGACACAATTAAGCTACACTGACCAGCCCATGAAGATCTCATTGTATGGAATACATGGCGAGAAGGAGAATATTCCCTACATTATGCCTACTTTGAACACAAACAGCACCGTGTCTTTCCTGTTGACCACGGATGCAGACATCGGAGAGCTGCTGATGGTTAAACTTCTCTGGGAGAAAGACACGCTCATCAGCTGGCCTTGGTGGAACTCCGACACCTTCCACATTCGCAAACTGCGCATCAAGTCTGGAGAGACACAGTCAAAAATCATCTTTAGTGCAAAAGAAAGTGAATTTTCCTACCTTTCCCGTGGAGGTGAGGCGGCCGTCTTCGTGAAAGACAAAGAGGCCCAGTCGAGCCGCAAAAACCAGAGATTGCACAAGATGAAGATGCACGGCAGTTCATTCAAACAGAACACCGAGTAAAGACCCACGTCAAAATCCACCTCCGCTGGGATCTGGCACAGAATCTGCCAGGGAAAACTGGAATGGTAGAATCTGACCTTTCCCGTATATATTCGGACTAACAACCTTCACCCAACCCAAGTCCAGGAGCACATTCTGCAAGAAACCGCATCTTGAAAATGTTACTGCTGTGcagttataaaacaaaaaaatatatatttttggaaagaTCACAGGTCTGGCTAGACAATCTTTTCTGAAATGGTTTAATACATATAATGATAATTATGTCTCtatgtaatatatttatgcaAGTAATCTGTTCCAACCTATCTAAAAGTGACTTGCACTTAGCTAACAGGGTTTGCTAGTTGTCCACCAAAGAGACTTTCATTTTTGAGAAAAGAAAAAGCCACTCGAAATTATATGGATCGTTGAGTTTATCAGTATTATTCCACTGAACAACAAAGTAATGCCTTTGTTTGGTTGTACTGTGAATTAAGTTGTACCAAAGCGGTTTTCTAACTATGCTAATCCTCTTTGCCTCAGTTCCGAAAGCAAAACTTTCAGATTTGTCTTTGTTGCAGTCATAAGTCAGTCTGAATGAAATgctttaacaaaacaaaatgggACCAaatcctctttctctctctgctgAATCAAGATGAAAtgattattgtaaatatttgtaatttgtcaTTATATATACTTACAAACAGCTCTTCAGATGTCtacctttctttcttttcttgggTTATTGTGTCTGGCACAGGTCACTTTAAAGGCTTTGTCTGCCTTTGATTTAGTTTGCTTCGGTAAATCGAGCAAAATCAACAAACAGTTCTACCACTTTTGATTTGTTTCCTGTCACAGACTTTTAAAGCACCTCAGAAGTTCTTTCATCTGGGTTTCCTAAATGCAATGAGGCAAGAAACTACTTTCATTTACACTTGAGCCAGCTAAGACTTGGTTTGATCTTGACTTGAAGGAAAAACAAATGTCTTTTTTCAAGCCTGAAAGTGTTGACCGCTCCACATAATAGCCAGAAGTACATCAAAACTGTCCCTTTTTCCTATTTATTGAATGTACATATTTGTATATTAAGCACATAGTATATGTATACAATGATTCTGTGGTGCTCTTGCCATTCTTTCGAGTTATGTAGCCTTtctatttttataaacatttttcaaacattGACTGATTGAAGGAAATGAGCTGAACAGTATTGGGTCACCTGTTGTGATCGTATGAATTTATAAGCCGTGCACTGTATGATGTCATTTTAATAAACGTTATGTTGCAGTATTTGAGCACTTTAggcttttaatttaaatatacaccagcatacatacatattttatgtCCAAATGCCATGTTTGTACTAAATATGTGTTTTATTCTGTTATTATAAGACCATAGAAAGAAAACTGCACTGAactgatttaattttaaaatccCTGATAACTacttaaaacaaattttaaattggCTGCAAATTTCTCAACAACAAATGTATGTGTAAG

Function

symbol description
lpl Predicted to enable apolipoprotein binding activity; lipoprotein lipase activity; and phospholipase activity. Acts upstream of or within definitive hemopoiesis and response to (R)-carnitine. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of chylomicron and very-low-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; head; immature eye; midbrain; and ovary. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein lipase).

GO:

id name namespace
GO:0006629 lipid metabolic process biological_process
GO:0061959 response to (R)-carnitine biological_process
GO:0006633 fatty acid biosynthetic process biological_process
GO:0019433 triglyceride catabolic process biological_process
GO:0016042 lipid catabolic process biological_process
GO:0005576 extracellular region cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005615 extracellular space cellular_component
GO:0034361 very-low-density lipoprotein particle cellular_component
GO:0042627 chylomicron cellular_component
GO:0016020 membrane cellular_component
GO:0004465 lipoprotein lipase activity molecular_function
GO:0034185 apolipoprotein binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0052689 carboxylic ester hydrolase activity molecular_function
GO:0008201 heparin binding molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0004620 phospholipase activity molecular_function
GO:0016298 lipase activity molecular_function

KEGG:

id description
ko00561 Glycerolipid metabolism
ko03320 PPAR signaling pathway
ko04979 Cholesterol metabolism
ko05010 Alzheimer disease
ko04147 Exosome
ko00536 Glycosaminoglycan binding proteins
ko00537 Glycosylphosphatidylinositol (GPI)-anchored proteins

ZFIN:

id description
ZDB-GENE-990415-139 Predicted to enable apolipoprotein binding activity; lipoprotein lipase activity; and phospholipase activity. Acts upstream of or within definitive hemopoiesis and response to (R)-carnitine. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of chylomicron and very-low-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; head; immature eye; midbrain; and ovary. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein lipase).

Ensembl:

ensembl_id ENSDARG00000087697

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00040308 True 3322 mRNA 0.41 10 15624371 15630421

Neighbor

gene id symbol gene type direction distance location
XLOC_020302 gpc1a coding upstream 76170 15507218 ~ 15548201 (+)
XLOC_020301 gpc5b coding upstream 122954 15438513 ~ 15501417 (+)
XLOC_020300 NA coding upstream 264187 15358159 ~ 15360184 (+)
XLOC_020299 rrp36 coding upstream 271825 15343953 ~ 15352546 (+)
XLOC_020298 sult3st2 coding upstream 282206 15336752 ~ 15342165 (+)
XLOC_020304 CABZ01090041.1 coding downstream 2592 15633013 ~ 15643059 (+)
XLOC_020305 fam32a coding downstream 89960 15720381 ~ 15721823 (+)
XLOC_020306 BX323550.1 coding downstream 102546 15732967 ~ 15734843 (+)
XLOC_020307 si:dkeyp-70f9.7 coding downstream 116916 15747337 ~ 15748440 (+)
XLOC_020308 BX323550.5 coding downstream 157560 15787981 ~ 15937268 (+)
XLOC_020293 NA non-coding upstream 522945 15099470 ~ 15101426 (+)
XLOC_020292 NA non-coding upstream 558419 15058189 ~ 15065952 (+)
XLOC_020291 NA non-coding upstream 613683 14991684 ~ 15010688 (+)
XLOC_020290 NA non-coding upstream 742945 14879864 ~ 14881426 (+)
XLOC_020313 CR751228.1 non-coding downstream 647077 16277498 ~ 16277625 (+)
XLOC_020322 BX322568.1 non-coding downstream 1008889 16639310 ~ 16639425 (+)
XLOC_020324 NA non-coding downstream 1179863 16810284 ~ 16811361 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) G158073 NA non-coding CI01000030 null 937497 ~ 942841 (-)
bowfin (Amia calva) G142690 NA non-coding CM030139.1 CM030139.1 22648940 ~ 22706530 (+)
bowfin (Amia calva) AMCG00006012 NA coding CM030142.1 CM030142.1 14249791 ~ 14256738 (-)
mexican tetra (Astyanax mexicanus) G132712 NA non-coding NC_035911.1 CM008314.1 17579869 ~ 17592063 (-)