XLOC_020309 (klf2a)


Basic Information

Item Value
gene id XLOC_020309
gene name klf2a
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007133.7
NCBI id CM002906.2
chromosome length 39133080
location 15898221 ~ 15900919 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00040315
GTGATTTAAAGAAGAGCCCGTGCGCTCTCAACATCCAAGACGAAAGGCGCACACGCCGGAGAGCAGCAGCTATATACCGGGGCTAAAATTAGGGACGGATAGTGCGTATTTCCTCCGCTTCTTATAATTGGTCCAGCTTGCGCTGCCGTGATATTTATAAGATAAAGGTCTTCCACCACTCATACTTTCTGCATGAGTGTTAAACATAGTGTAAAGAGCAGAGCAGAGTTGTAGTGCACTACAACCAAAGTTTCTCCGAGGGATTGCAACAAATCCCCGATCTTTAAAGTTTGTTTTACCTTAACTGGGACGACTGGAAATGGCTTTGAGTGGAACGATTTTACCGTCTATTTCCACATTTTCGGCGCAGAAGGAAAAATGCTGGGAGAACAGGTGGAAGGATGAACTGGACAGGTCCATGCATCTCAGCTGCATAGCTGACCTATCTAACATGGACAACCTCAACAGAATAACAGACGACGAAGATCTTGACAAGTACCTGGATCTGGAGTTTATACTGGCCAACACTGCAGGTTCTGACAATCTCGGACTCGGCATGGCAGGCGACTACAGAATGCAAGAGTCCAGAAACATGTACAACCCGACTACATACTCGGTGCCTGAGATCAACCCATCACCACCTCCACCGTACACCACCAGCCTCATGGCAGAGCTTCTGCAGTCTGACATTGACACCTACTGCCAACCGTCTCTCCAGGGAAGATTCCTAGTCAGGCCTGCTTTCCCCACTCAGGACATTTCGGAGTGTATCAAAGTGGAGCCCTGCATGGATAGTTACGGACCTGTACGAGGAATGGTTCCCAAAGTCAAACAAGAGGGCAACGGTGCATGCATGAGATCCTATGAGCAGCCAAGACTAGCCAACTCTCCCCAGGGAGCAGGCAGCATGACTCCCCCACAGAGCCCTGCGGAGCTCATCAACACAGACTGTCAGTCACACTCGCAGATGTGCCATGCCTTAACGTTCAGCCAGAGCTATCAAGGCAACACAGGATTTCCCCACGCAGCACCTCCACAGATGCAGCTGCCTTACCAAAGCACACATCACTTCAGCATGTGCGACGATGGGCTTGCAATGCCCAACGCCAACCAAAGAGTACTTCTGACACCACCCTCATCTCCTCTAGAGCTGGACGCCAAACCAAAGAGGGGGCGCCGCACGTGGCCGAGGAAACGCACGGCGACTCACACTTGCACTTTTTCTGGATGTGGCAAAACTTACACAAAAAGTTCTCACTTGAAGGCTCATCACAGAACACACACAGGCGAGAAGCCCTATCATTGCAGTTGGGAAGGCTGTGGGTGGAAGTTCGCCCGTTCTGATGAATTGACCCGTCACTTCCGCAAGCACACCGGACACCGACCCTTCCAGTGCCACCTGTGCGAACGTGCCTTCTCCAGGTCCGACCATCTCGCCCTTCATATGAAACGTCATATGTAGGAACGGACTCTGGAAAATGTGGACTAAACGCACTGAACAGTGAACATTGtctgtacccccccccccccccccccccccccccccccccctcttatTTAAAGTATGGTGAAGGGGAAACATGAACTGACTTGACCTATTGCTTGTAGCTGGTTCTACACTTCAATTCTTTACAGAATTTACAGAAACAAACTATATTTTTCGTTTCCAAAGAGCAAGTTCAACTCATACTATAGGCTGGACCTAAACCTCAAGACGGAACTGGAATCAGACAGTATAATGTGCTTTAAGTTAACATGATGTGCTGCGGACATCACGACAGTGCCTTTTAATATGCGTATACATCTCACGAGTGCCACGAATACTGGCGTTTTTTTTAACGACAAATGTATGCTATTGTGTCAAGAAACTAAATAAGCTTTGTAAGACAATGTTTTCCtctttcaaaactgccttaaaaGTTAACAAAAGGGGCGTTAACTGAATGTTTTAAGTAATTTGTGCATTTATCGACATaaacgtttttatttttaaaaatcagggTCTTATGGTTTCGTTTTTTTTAAACGCAATTTGTATGCTGTTAACGTTGAATTGCAGACTGTCCCATGTTTGGATGACATGATAAGGGCTATGTGAGTTGTTCTGGACCAAAGCATTTTATGTACATAATTTATAcactgtatatattgtacatattAAACTTAAATTGCGATATAAA

Function

symbol description
klf2a Enables transcription cis-regulatory region binding activity. Acts upstream of or within circulatory system development; nitric oxide biosynthetic process; and regulation of cell fate specification. Is expressed in several structures, including EVL; cardiovascular system; cloaca; fin; and pectoral fin bud. Orthologous to human KLF2 (Kruppel like factor 2).

GO:

id name namespace
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0061444 endocardial cushion cell development biological_process
GO:0003171 atrioventricular valve development biological_process
GO:0003181 atrioventricular valve morphogenesis biological_process
GO:0001525 angiogenesis biological_process
GO:0003223 ventricular compact myocardium morphogenesis biological_process
GO:0006809 nitric oxide biosynthetic process biological_process
GO:0042662 negative regulation of mesodermal cell fate specification biological_process
GO:0042665 regulation of ectodermal cell fate specification biological_process
GO:0046872 metal ion binding molecular_function
GO:0003676 nucleic acid binding molecular_function
GO:0000976 transcription regulatory region sequence-specific DNA binding molecular_function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-011109-1 Enables transcription cis-regulatory region binding activity. Acts upstream of or within circulatory system development; nitric oxide biosynthetic process; and regulation of cell fate specification. Is expressed in several structures, including EVL; cardiovascular system; cloaca; fin; and pectoral fin bud. Orthologous to human KLF2 (Kruppel like factor 2).

Ensembl:

ensembl_id ENSDARG00000042667

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00040315 True 2180 mRNA 0.47 3 15898221 15900919

Neighbor

gene id symbol gene type direction distance location
XLOC_020307 si:dkeyp-70f9.7 coding upstream 149781 15747337 ~ 15748440 (+)
XLOC_020306 BX323550.1 coding upstream 163378 15732967 ~ 15734843 (+)
XLOC_020305 fam32a coding upstream 176398 15720381 ~ 15721823 (+)
XLOC_020304 CABZ01090041.1 coding upstream 255162 15633013 ~ 15643059 (+)
XLOC_020303 lpl coding upstream 267800 15624371 ~ 15630421 (+)
XLOC_020310 stil coding downstream 58925 15959844 ~ 16016271 (+)
XLOC_020311 serpinc1 coding downstream 121292 16022211 ~ 16028191 (+)
XLOC_020312 dph5 coding downstream 196266 16097185 ~ 16121408 (+)
XLOC_020313 CR751228.1 coding downstream 376579 16277498 ~ 16277625 (+)
XLOC_020314 dbt coding downstream 392152 16293071 ~ 16305821 (+)
XLOC_020300 NA non-coding upstream 538037 15358159 ~ 15360184 (+)
XLOC_020293 NA non-coding upstream 796795 15099470 ~ 15101426 (+)
XLOC_020292 NA non-coding upstream 832269 15058189 ~ 15065952 (+)
XLOC_020291 NA non-coding upstream 887533 14991684 ~ 15010688 (+)
XLOC_020322 BX322568.1 non-coding downstream 738391 16639310 ~ 16639425 (+)
XLOC_020324 NA non-coding downstream 909365 16810284 ~ 16811361 (+)
XLOC_020339 BX908731.2 non-coding downstream 1923540 17824459 ~ 17824573 (+)
XLOC_020344 NA non-coding downstream 2342839 18243758 ~ 18304288 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000030_01091944_01093682 KLF2A coding CI01000030 null 1091699 ~ 1094481 (+)