XLOC_020946 (insrb)


Basic Information

Item Value
gene id XLOC_020946
gene name insrb
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007133.7
NCBI id CM002906.2
chromosome length 39133080
location 10927370 ~ 11054244 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00041206
GAGAGACGAGAGGGGGAAAACCACACCGCCGACAACACGAGACAACTTTTGCCCACTTTCAGCCCATTCCCACGCCGATGAGCTCAGCCAGACCGCGCACCGGGCTCTCGTCGACGGAACCGAGCGGTTTAACGGGCAGGCCGAACACGCGCTGGACGCCGCTCTGTTGATGAACGTGGAAGATTAAAACGCGACGCGACCGtgacgcgcacacacgcacgcacacacatacacacacacacttcgggATCATTGTGCTGGAAGCAAAGGCTTCAGCAGAACATCTCTGCTTTTATTCTCCTCTCAGCGTTGTGAAGATACGCAAAGGAGTGTGGATATTTAATTTTAGAGGACGCTGGTTTATTTCTGACAGCAGAATCGCTACAGAAACCATTGTGGTGTGTGTGCAGCATGTGTTTATGTGGATGAGGAGATGCCCATTTTTTGACGGGGACATTTGGCAGTGCATGAAACGACCTGTGGAATAacgattatattttttattttaatattataatttttgctTGTGCCCTCGGAGACATTGTTGGCTTTTTTGACAATTGAGAAgcgatttttttgtgtgtaaaacgtGGAcgtattttttctttgttttaaataCAACCTTGTCTACCTTTTTGCTGATATTGCTGTAGCAAACTAAAGCAGGGGTTATGAAAAAGTTGCAATGTactgtacccttaagggtacctcATTCCTAGAAGTGTGGGATTGATTCCATGGAAGAGATGCATGGACGTTTTTCATGCTTGCTCCACTAAAAGCCAGGATGCATCCGAAAAATCGCTCAAAATGATTTTCAGTCGTTTATTTTTCTCAAGGGTGCAGGATCATGTTATTTAACACTCATTTCACCCCTGCTGTGTAATGTTAGGCAACAACTACTTCAGTTGAACATTATCTTTATCTGAAGCACGCTGGACCCCCGGGTCCCCTTCTTGGGGGGTCTGatttaacttttttgttgttgtttttgatacAAGACAAACAACCTTATTTTCCTTTTAATTTTTGATTTTCGGACACACCAGAGGTGGATTTAATTTTCCAAGGAAACCAAAACGTGTCGCGAGGCAGAATGCGGCTGGACACATCTGTGGTTGTTTTGGTCACTTTCGCCTACATCTTGTGCCTCTGCGGATCACTACATGGAGAAATTTGCCCCAGCACAGACATCCGCAACATCGCCACCAACCTGCGGGTTTTGGAGAACTGCACTGTAATCGAAGGCCACCTGAAGATCCTGCTCATGTTCAAGACCACGCAGGAGGATTTCAGGGGCTTGAGCTTTCCGAAACTGGTCATGGTCACCGACTATCTGCTCATCTTCCGCGTCTATGGCCTGGAGAGCCTTGGCAGCCTCTTTCCAAACCTCACTGTCATCCGCGGCAGCAACCTGTTTTTCAACTACGCCCTAGTCATGTTCGAGATGATCCAGATGAAGGAAATCGGCCTCCACAGTTTGACCAACATCACGCGGGGAGCGGTGCGCATCGAGAAGAACCCAAACCTGTGCTATTTGTCCACTCTGGACTGGTCCAAGATCTTGGATTCGGTGGAGGACAATTATATCGTAGCAAACAAGGACGATTTGGAGTGTGGAAACATCTGTCCAGGCACCATCGCGGGGACGATATCCTGCAAACAGACCACCATAAACGGAAATTTTGGAGAGCGATGCTGGAACCAGAATCATTGCCAGAGAAtttgTCCTTCTGAATGTGTCCACGGAGCCTGTACGTCCCATAAGGAGTGCTGTCACGAGCAGTGTCTGGGTGGCTGCTCTGTGCCGGGGAACTCCACCAAATGCGTGGCCTGCCGCAACTTCCTGTACGGCGAGGCGTGCGTGGACCGCTGTCCGCCAGGATACTACACCTTTAAGAGCTGGCGCTGCGTGTCCCTTCAGTTCTGCCAGGACCTGCACAACCAGTGTAAGGACAAGAGCGGAGACTGTCACGCATACGTCATCCACAACGGGGCCTGCATCCCAGAATGCCCGTCCGGATACACCACCGTCAACTCCACCTCGTTGACCTGCATGCCCTGCACCGGTCGGTGTCCTAAAGTGTGTACAGGAGTGCAGACGGTGGACTCGGTCACGGCCGCTCAGGCGCTGCGGGGATGCACAGTGCTCAACGGCAGCCTCATCATTAAGATCAGCGGAGGAAACAGCATCGCCGCGGAGCTGGAGTCCAGTCTGGGTCAGCTGGAGGAGATCACAGGATATCTGACCATCCGAAGGGCCTATGCTCTCGTCTCACTCTCCTTCCTCCGCAAGCTGCATCTCATTCGTGGAGAAACGCTGGACGGCGGAAACTATTCGTTCCACGCGATGGACAACCAGAACCTGCGCCAGCTGTGGGACTGGAACAAACACAACCTCACCATCCTCAAAGGCCGAATGAAGTTCATCCAAAACGGCAAACTCTGCAAGTCTGAGATCCTGCGCATGGAACAAGCCACCGGCACCAAGAACAGGATGAACGACATCAGCAATGAGAAAGACCAGTCCTACTGTGAAAGTCACATACTCAAATTTACACAAATCCGCACCATGAGCGACAAGATCCTCATCCGATGGGAGTCCTTCTGGCCCTCGGACTTCAGAGACCTGCTGGGATTCATGGTGCTCTACAAGGAAGCTCCTCACAGGAACGTGACTGAATACGACGGGCAGGACGCGTGTGGCTCTAACAGCTGGGCCATTGCAGACGTAGAGCCGCCGCAGAGACCTAGTGAAGGTAAAGAGGTGGAGCCGGGGTACCTGATCATGCCTCTCAAGCCCTGGACTCAATACGCCGTCATGGTGAAAGCCCAGCTCGCAGCCTCAGAAGACCATCAGGTCAGAGGAGCCAAGACCGAGATCATCTACGTCAGGACCAACGCCACACGGCCTTCAGTGCCGCTGGATCCTCACTCCTGGTCAAACTCGTCCTCTCAGATCATCCTCAAGTGGAAACCGCCGTCAGACCCCAATGGAAACATCACACACTACATCATCTACTGCCAGAAGCAGAGCGAGGACATCACACACTACAAGTTTGACTACTGCCAGCAAGGTATGAAAGTGCCGTCCCACACGCCGACGCACCACGACGTCGAGGAGGACCAGAAGCTTAACCAGACGGAGGTTCCAGACCAGAAGGGGCACTGCTGCGCCTGTCCCAAAACCGAAATGCAGCTCAAGAAAGAGGCAGAGGAAACTGAGTTTCGCAAGACCTTCGAGAACTACCTGCACAATGAAGTGTTCGAGCCCAGGCCCCACCGTCGGCGTCGCTCAGTTGGCGTAGCCAATGCAACGTTGCCAAATTTTGGAACCACACCAACTATAATACCCAACTTTCCAACCACTTCAATCCCAGAGGAAGAAAAGAGCCGGAAGATGGTGTTCAAAGCCAGCTCCAAAGAGGCCATGGTCATCTCCAACCTGCTCCACTTCACCAGCTACCAGATTGAGATCCACGCTTGCAACGACCCCACAGACCCGGGCCGCTGCAGCATGCCAACATACGTCAAAGCCCGCACACTCCCTGAACTGAAAGCTGATGTCATTGCCGAGCCAGTGACTCACGAATTTTTTCCTGACGAGCCGGATGTTGTTTACATCAGATGGAAAGAGCCCAAAACTCCTAACGGCATGATCATACTGTATGAAGTCAAGTATCTACGGATGTCTGATAACTACGAGGATCAAATCTGCGTGTCCAGAATTTCCTATGAGAAAAACCATGGCTATCGATTAAGAGTAGGGCATCCTGGGAATTACAGTGTGCGAGTTCGTGCCACCTCGCTGGCTGGCAATGGTTCTTGGACTGATCCTGCATACTTTTATGTTCAAGACAGGGAAATGAGCATGAAAATCGTTATCATCCTAGCCATCTGCATTTTCTTACTGGTGATTCTGGCCAGCGTAGGCTACTTTGTCTTGAAGAAGAAACAAACTGAAGGACCAACTGGCCCACTGATTGCTTCCTCCAACCCAGAATATATAAGTGCAAATGATGTGTACATCCCTGACGAATGGGAAGTTCCTCGTGAGAAGATCACTGTCATGAGAGAGCTTGGGCAGGGATCATTTGGGATGGTGTATGAAGGCATTGCTAAAGACATCATAAAGGGTGAACCGGACACTCGAGTTGCTGTGAAAACTGTAAATGAGTCGGCGAGTCTGCGCGAGAGGATTGAGTTCCTTAATGAGGCTTCAGTCATGAAAGCCTTTAGCTGCCACCATGTGGTGCGTTTGCTTGGTGTGGTATCCAAGGGACAGCCGACATTGGTTGTCATGGAACTAATGACGCACGGAGATCTGAAAAGCTACCTGCGTAGCCTGAGGCCTGATGCGGAAAATAACCCAGGCAGTCCACCGCCAACCCTAAAGGAGATGATCCAAATGTCAGCTGAGATAGCAGATGGGATGGCATATCTCAATGCTAAGAAGTTTGTCCACAGAGATCTCGCTGCAAGAAACTGCATGGTGGCTGAAGATTACACCGTCAAAATTGGAGATTTTGGCATGACGCGAGACATTTACGAGACTGATTACTATCGCAAGGGCGGGAAAGGCCTTCTGCCTGTCAGATGGATGGCACCAGAGTCGTTGAAAGATGGTGTATTCACTGCTCACTCAGACTGCTGGTCTTTCGGAGTGGTGTTATGGGAGATCAGCACACTTGCTGAGCAGCCGTACCAGGGACTGTCCAATGAGCAGGTGCTCAAGTTCGTCATGGACGGAGGATACCTGGATAGACCGGAGAACTGTCCGGAGAGAATGCACAACCTCATGCAGATGTGTTGGCAGTACAACCCGAAGATGCGGCCAACCTTCCACGAGATCATCGAGATGATCAAGGAGGACCTGCATCCTACTTTTCAAGAGGTCTCGTTCTTCTACAGCGAGGAGAACAAAGCGCCTGAGAGCGAGGAGTTTGACATGGACTTCGAGAACATGGAGAGCATACCACTGGACCCCTCATCCTATTCCCAACGCGAGGAGAGCCACAGTAGAGACAACGGCCCCTCAGTGGGCCTACGGGGCAATTACGAGGAGCATGTGCCCTACACACATATGAACGGTGGAAAGAAAAATGGCCGAATTCTGTCTTTACCCAGATCTAGTCCGTCCTAACATTTGCCTCACCGTTTcttctaccttttttttttttaaagaaagtttttaaatgcattatttttgcaGAGGCCCTTAAAGATACAGATCTCAggtcttttttgtttgttgttgttgttgtcgtcatCGTTGTCGTCTATGTTGTTTCCGTCTCACGGCTAAACTCTTATGGTTACAACGAAAATGGACGTTTCCTTTCTCAACCAACACCGTTCGCTTTCTGACACTTTTTACACTTTTGCCAAGTTTTCGAGACAGTTTGGTTTTGGGTGGAGGGAAAGCAAACTGTGAACATGACTAAATCAACCAGAAAAGCTGCTTTGGCTACGTCACCTCAATGTCCACTTCCTTCGACCCTTGGATGCTTATTTTTcctgtttctctttttttgttcaaAGTGGAAATCTTTTAATATAGTGGCCTTTTATTAAGTGGCCTATAAAAAAGAGAAGTGTCTATAAATATTTGTGTTCGTTTCTTTAAAGCAACGACTTTACAGTG

Function

symbol description
insrb Predicted to enable insulin receptor substrate binding activity and insulin-activated receptor activity. Acts upstream of or within with a positive effect on glycolytic process. Acts upstream of or within chordate embryonic development and developmental growth. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in several structures, including endoderm; fertilized egg; immature eye; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor).

GO:

id name namespace
GO:0033674 positive regulation of kinase activity biological_process
GO:0043009 chordate embryonic development biological_process
GO:0006096 glycolytic process biological_process
GO:0007275 multicellular organism development biological_process
GO:0043410 positive regulation of MAPK cascade biological_process
GO:0048589 developmental growth biological_process
GO:0006468 protein phosphorylation biological_process
GO:0042593 glucose homeostasis biological_process
GO:0051897 positive regulation of protein kinase B signaling biological_process
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling biological_process
GO:0016310 phosphorylation biological_process
GO:0046777 protein autophosphorylation biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0030424 axon cellular_component
GO:0005887 integral component of plasma membrane cellular_component
GO:0005899 insulin receptor complex cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0043235 receptor complex cellular_component
GO:0043548 phosphatidylinositol 3-kinase binding molecular_function
GO:0043560 insulin receptor substrate binding molecular_function
GO:0016740 transferase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0016301 kinase activity molecular_function
GO:0004713 protein tyrosine kinase activity molecular_function
GO:0004714 transmembrane receptor protein tyrosine kinase activity molecular_function
GO:0005009 insulin-activated receptor activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-020503-4 Predicted to enable insulin receptor substrate binding activity and insulin-activated receptor activity. Acts upstream of or within with a positive effect on glycolytic process. Acts upstream of or within chordate embryonic development and developmental growth. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in several structures, including endoderm; fertilized egg; immature eye; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor).

Ensembl:

ensembl_id ENSDARG00000071524

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00041206 True 5644 mRNA 0.50 21 10927370 11054244

Neighbor

gene id symbol gene type direction distance location
XLOC_020945 NA coding downstream 412 10922765 ~ 10926958 (-)
XLOC_020944 BX908744.2 coding downstream 9577 10903510 ~ 10917793 (-)
XLOC_020943 BX908744.1 coding downstream 26394 10895963 ~ 10900976 (-)
XLOC_020942 arhgef18b coding downstream 36157 10814204 ~ 10891213 (-)
XLOC_020941 timm13 coding downstream 152635 10771115 ~ 10774735 (-)
XLOC_020947 use1 coding upstream 16598 11070842 ~ 11079068 (-)
XLOC_020948 NA coding upstream 28698 11082942 ~ 11097837 (-)
XLOC_020949 NA coding upstream 33160 11087404 ~ 11089700 (-)
XLOC_020950 BX649485.2 coding upstream 36094 11090338 ~ 11091099 (-)
XLOC_020951 NA coding upstream 48661 11102905 ~ 11104271 (-)
XLOC_020940 BX908398.1 non-coding downstream 163323 10763933 ~ 10764047 (-)
XLOC_020938 NA non-coding downstream 215839 10706775 ~ 10711531 (-)
XLOC_020961 NA non-coding upstream 617945 11672189 ~ 11674421 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
bowfin (Amia calva) AMCG00005920 NA coding CM030142.1 CM030142.1 12521871 ~ 12544857 (+)