LOC110520024 (cxcr4)


Basic Information

Item Value
gene id LOC110520024
gene name cxcr4
gene type coding
species rainbow trout (Oncorhynchus mykiss)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_048567.1
NCBI id CM023221.2
chromosome length 85311031
location 45500138 ~ 45502139 (+)
genome version USDA_OmykA_1.1_2020_rainbow_trout_Genome

Sequence

>NM_001124342.2
CGCGGAGATAACCTGCATCACTGCGTTGCCACGATGTCTACTTTTTACGAGGTCGAACACATATTTTTTGACAACACCAGCTATGAAGAATCAGGGGATTTTGACTTGGATTTGGGTTTCGAGGAGCCGTGCAACAGAGTCGGAGGTGATGATTTTCAAAGGATCTTCTTACCGACAGTTTATGGAATAATCTTTCTGCTTGGAATCGTCGGAAATGGACTGGTAGTAACAGTGATGGGCTACCAGAAAAAGGTCAAAACGATGACTGATAAATACAGGCTCCATCTTTCTGTGGCTGACCTCCTACTCGTCTTCACGCTACCTTTCTGGGCAGTGGATGCGGCCAGCAGTTGGTACTTTGGtggcttcctctgtaccactgtgCACGTGATCTACACCATCAACCTGTATAGCAGTGTTCTGATTCTGGCTTTCATCAGCGTGGACAGGTACCTGGCAGTGGTGCATGCCACCAACAGCCAAACCACCAGGAAGAGGAAGCTGCTTGCAGAGAGATGGATCTATGTGGCGGTATGGCTACCTGCTGCTGTTCTCACTGTGCCTGACATAGTGTTTGCCACAGCTCTGGATGGAGGCTCCAGAACCATCTGCCAGCGCATCTACCCCCAGAAGACCAGCTTCTACTGGATGGCTGGGTTCCGTTTCCAGCACATTCTGGTGGGCTTTGTCCTGCCTGGTTTGGTCATCCTCACCTGCTACTGCATCATCATTGCCAAGCTGTCCCAGGGAGCCAAGGGTCAAGTGTTGAAGAGGAAGGCTCTCAAGACCACCGTAATCCTCATCCTGTGCTTCTTCAGCTGCTGGCTGCCGTACTGTGTGGGGATCTTTCTGGACACCCTAATGTTGCTCAATGTGATCTCCCATAGCTGTGCCCTGGAGCAGAGTCTGCAGACCTGGCTCTTAATCACAGAGGCTCTGGCATACTTTCATTGCTGTCTCAACCCCATCCTTTATGCTTTCCTGGGCGTTAAGTTCAAGAAATCTGCCCGAGATGCACTGGCTGTCAGCAGTAGGTCAAGTCATAAAGTACTGACTAAAAAAAGAGGAGCCATTTCATCTGTATCCACTGAATCCGAGTCTTCAAGTGTCTTGTGCAGTTAGTCACCATCCTTTGACTTTTAAATCTCAGGTTGAAACTAAGCTTTCTTTTTCAGGGACAAACTACATTTTGTACAGTTTTGACACCAAAACAAAAAAGACGCTCTTTCTATTTGTAGTTgccacttacattttttttttgttgttcttgTCAAGAAAATAATTTTATGTACAAAGGAGATTTAATCTACAGGCAGAGCCTGATGTCCATTGACTGGTCAACTGTATATATCAATTCTGCTACAGACGCAATTCCTTGCGGACTATCATAGAAGATACATTGTTCTAATACGGGACATGTCATACTTCATCATGTCTGCTTAGGGATACTATTTGTTCGTTTAAAATATTTGTAGATAGTTGTTTGCCTTTTTTCCGTTCGCACTTAACTTGTGTGATTAGAAGTTATATTATTTATTGCTGTCGCTCACACTGAATGTTTGGTATAATTATTTCACTATTTTGTTATAAGTGTTTGTATCATTTCAATGTCAATGCCATTTTGTTCAAGTGTTCTAAAATAAAATGTGGATAAATGACA

Function

symbol description
cxcr4 Enables several functions, including C-X-C motif chemokine 12 receptor activity; cytoskeletal protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including CXCL12-activated CXCR4 signaling pathway; positive regulation of macrophage migration inhibitory factor signaling pathway; and response to hypoxia. Acts upstream of or within calcium-mediated signaling. Located in several cellular components, including cell leading edge; cell surface; and late endosome. Part of protein-containing complex. Colocalizes with early endosome and lysosome. Implicated in WHIM syndrome; hematologic cancer (multiple); leukopenia; osteoporosis; and pancreatic adenocarcinoma. Biomarker of Hermansky-Pudlak syndrome; acute myeloid leukemia; paroxysmal nocturnal hemoglobinuria; and ulcerative colitis.

NR:

description
C-X-C chemokine receptor type 4-like

GO:

id name namespace
GO:0007186 G protein-coupled receptor signaling pathway biological_process
GO:0042119 neutrophil activation biological_process
GO:0006935 chemotaxis biological_process
GO:0070098 chemokine-mediated signaling pathway biological_process
GO:0016021 integral component of membrane cellular_component
GO:0016494 C-X-C chemokine receptor activity molecular_function

KEGG:

id description
K04189 CXCR4, CD184; C-X-C chemokine receptor type 4

RNA

RNA id representative length rna type GC content exon number start site end site
NM_001124342.2 True 1660 mRNA 0.44 3 45500138 45502139

Neighbor

gene id symbol gene type direction distance location
LOC118956876 NA coding upstream 4158 45494309 ~ 45495980 (+)
glsb LOC106586143 coding upstream 100637 45340329 ~ 45399501 (+)
LOC110520018 LOC106586140 coding upstream 207504 45279937 ~ 45292634 (+)
LOC110520014 ormdl1 coding upstream 290547 45191720 ~ 45209591 (+)
LOC100135920 LOC100135920 coding upstream 391551 45105779 ~ 45108587 (+)
dars1 sydc coding downstream 7326 45509465 ~ 45539298 (+)
pnkd pnkd coding downstream 47773 45549912 ~ 45561382 (+)
LOC110520030 gmpaa coding downstream 69511 45571650 ~ 45580003 (+)
asic4a LOC106586149 coding downstream 224098 45726237 ~ 45823301 (+)
LOC110504149 wnt6 coding downstream 350043 45852182 ~ 45884194 (+)
G262852 NA non-coding upstream 11758 45400277 ~ 45488380 (+)
G262875 NA non-coding upstream 164772 45335127 ~ 45335366 (+)
G262827 NA non-coding upstream 245690 45254197 ~ 45254448 (+)
G262820 NA non-coding upstream 257047 45242850 ~ 45243091 (+)
G262814 NA non-coding upstream 272754 45227173 ~ 45227384 (+)
G263331 NA non-coding downstream 89114 45591253 ~ 45591539 (+)
G263362 NA non-coding downstream 114999 45617138 ~ 45617349 (+)
G263372 NA non-coding downstream 120859 45622998 ~ 45623306 (+)
G263376 NA non-coding downstream 122138 45624277 ~ 45624493 (+)
G263399 NA non-coding downstream 142054 45644193 ~ 45644394 (+)
G262037 NA other upstream 974730 44520419 ~ 44525408 (+)
G261749 NA other upstream 1247587 44252069 ~ 44252551 (+)
LOC110519969 LOC106586020 other upstream 5047958 40440040 ~ 40452542 (+)
LOC110519960 LOC106586058 other upstream 5832050 39658753 ~ 39668297 (+)
G254816 NA other upstream 6655582 38843510 ~ 38844556 (+)
G263547 LOC106586150 other downstream 336782 45838921 ~ 45839480 (+)
G263710 NA other downstream 431980 45934119 ~ 45934418 (+)
G263733 LOC106586158 other downstream 573345 46075484 ~ 46079425 (+)
G263859 LOC107588258 other downstream 681995 46184134 ~ 46184804 (+)
LOC110520046 LOC106586167 other downstream 1328869 46801058 ~ 46832288 (+)

Expression


Co-expression Network