XLOC_021736 (kmt2d)


Basic Information

Item Value
gene id XLOC_021736
gene name kmt2d
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007134.7
NCBI id CM002907.2
chromosome length 46223584
location 27756984 ~ 27768993 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00043127
ATGAAATGAAACGGACCTCGGCGATTATTATCCGGAGGATTGTTCCGATTATGTACGAGGACGTTAGCGGCGCATTGTAGATCTCTGTAATAGAGATCTTCTTCAGCAGGAATGGACGAGCAGAAATCAAACTGCGAAGAAAATGATTCAGAAACTGCAGCTGATGATGGGACCCCAGCAAAGGAGAGCGTCCAAGTCGAGGGGGAACTGAATGCCCCTGTTGCTGCAGAGGACATCTCAGGCACTACTGTGGACACTTCCAGCTCATCATTgGAGACTGTCAGGGCCTGTGCTCTCTGCAGCTGTGTGGAGCGTAGTCTACATGGCCAAGGAGAGCTTCAGTGTTTTGGACCCTCTTCTGATCGGCCTAGCTTGGAGTCCTCTGTTTCCACTTTGCCAGCAGCTGGAAACGATGACCTGTCTTCCATTGGATTCTCTGAATCCACCTGTCTGGCATCTCTCTTTGATGACACAGGGAGCTGCTGGGTTCACCACTGGTGTGCCGTGTGGTCAGAGGGAGTGGAACAGACTGAGGGTGAGGTGCTGATAAACGTGGATAAGGCAGTCGTCTCAGGGATACAGCGGCCATGTGATTATTGTAAACGGATGGGTGCTACTATCCGCTGCCGGGCCGAAGGCTGCTCACGGTTTTACCACTTCCCCTGCTCGGCTGCAAGTGGATCCTTCCAGTCCATGAAGCAGCTGGCGCTCCTCTGTCCAGAGCACATAGACAAGGCTGAGGAGATTGcCGGAGAGGAGGCACGGTGTGCAGTGTGTGACTCGGTTGGAGACCTGTCGGGTTTGCTGTACTGTACTGGATGTGGGCAGCACTATCACGATGCCTGTCTGGAGATTAGTGCTACACCACTTCAGCGGTCAGGATGGCAGTGTCCTGAGTGCAAGGTGTGCCAGACCTGCAGGCAACCAGGGGAGGATTCAAAGATGCTGGTTTGCGATGCTTGTGACAAGGGCTACCACACCTTCTGTCTACTGCCAGCCATGGACTCTGTTCCCCCTGATTCATGGAAGTGCAAACGGTGCCGTGTGTGTATTGACTGTGGCATGCGAGGGTTGAAGCTTCCTGGCTCTGAACAGTGGTTTGAGAGCTACACAGTATGTGAAGGTTGTCAGCGCAGGCGCACCTCTGTCTGCGGCGTGTGTAGTAAAGCCACTGAACCCTCGGTCTCCCTTCAACATCACTGTGCCATCTGCCACAG

Function

symbol description
kmt2d Predicted to enable histone binding activity; histone methyltransferase activity (H3-K4 specific); and transcription coactivator activity. Acts upstream of or within animal organ development and convergent extension involved in gastrulation. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Used to study Kabuki syndrome. Human ortholog(s) of this gene implicated in Kabuki syndrome and esophagus squamous cell carcinoma. Orthologous to human KMT2D (lysine methyltransferase 2D).

GO:

id name namespace
GO:0007507 heart development biological_process
GO:0003428 chondrocyte intercalation involved in growth plate cartilage morphogenesis biological_process
GO:0045944 positive regulation of transcription by RNA polymerase II biological_process
GO:0060026 convergent extension biological_process
GO:0060027 convergent extension involved in gastrulation biological_process
GO:0007420 brain development biological_process
GO:0048701 embryonic cranial skeleton morphogenesis biological_process
GO:0048703 embryonic viscerocranium morphogenesis biological_process
GO:0044666 MLL3/4 complex cellular_component
GO:0035097 histone methyltransferase complex cellular_component
GO:0005634 nucleus cellular_component
GO:0042393 histone binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0042800 histone methyltransferase activity (H3-K4 specific) molecular_function
GO:0003713 transcription coactivator activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-060223-2 Predicted to enable histone binding activity; histone methyltransferase activity (H3-K4 specific); and transcription coactivator activity. Acts upstream of or within animal organ development and convergent extension involved in gastrulation. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Used to study Kabuki syndrome. Human ortholog(s) of this gene implicated in Kabuki syndrome and esophagus squamous cell carcinoma. Orthologous to human KMT2D (lysine methyltransferase 2D).

Ensembl:

ensembl_id ENSDARG00000037060

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00043127 True 1217 mRNA 0.54 9 27756984 27768993

Neighbor

gene id symbol gene type direction distance location
XLOC_021735 dhh coding upstream 7922 27740592 ~ 27749062 (+)
XLOC_021734 lmbr1l coding upstream 29472 27703749 ~ 27727512 (+)
XLOC_021733 rps26 coding upstream 79468 27675581 ~ 27677516 (+)
XLOC_021732 wnt1 coding upstream 98930 27652906 ~ 27658054 (+)
XLOC_021731 NA coding upstream 240711 27508867 ~ 27516273 (+)
XLOC_021737 kmt2d coding downstream 9677 27778670 ~ 27793877 (+)
XLOC_021738 NA coding downstream 101746 27870739 ~ 27872705 (+)
XLOC_021739 NA coding downstream 143086 27912079 ~ 28007307 (+)
XLOC_021740 slc26a10 coding downstream 308960 28077953 ~ 28091109 (+)
XLOC_021741 c1galt1a coding downstream 323090 28092083 ~ 28136739 (+)
XLOC_021724 CT573349.1 non-coding upstream 828126 26928743 ~ 26928858 (+)
XLOC_021722 NA non-coding upstream 1131851 26591124 ~ 26625133 (+)
XLOC_021714 AL845287.1 non-coding upstream 1761843 25995027 ~ 25995141 (+)
XLOC_021691 BX957326.2 non-coding upstream 3196111 24556455 ~ 24560873 (+)
XLOC_021742 NA non-coding downstream 370766 28139759 ~ 28277430 (+)
XLOC_021745 NA non-coding downstream 621676 28390669 ~ 28420584 (+)
XLOC_021747 dre-let-7g-2 non-coding downstream 767368 28536361 ~ 28536457 (+)
XLOC_021748 dre-let-7h non-coding downstream 767672 28536665 ~ 28536778 (+)

Expression


Co-expression Network