XLOC_022419 (acvrl1)



Basic Information


Item Value
gene id XLOC_022419
gene name acvrl1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information


Item Value
chromosome id NC_007134.7
NCBI id CM002907.2
chromosome length 46223584
location 27835647 ~ 27857104 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence


>TCONS_00044227
ATGAGACCGCATTCCTAGTGAACCCCGGCTTAGACAATGAGAGGTGGGacaaaactgtatattttaaaatctgtaatCTAACCCCTAAATCAGGAACATTGCTCAAAGTTTGCTTTGCACTTATCGAGATGGAGTCGTCATGGGTTGATCTGGGAATGTTTATTTCTAAGCGGAAGAAGACTGTTCCTTCTCCGAGAAGCAGTTTCTTGTTTTCGGTTTATCAGCTCGAGATTTGactggagatatatatatataccacgaCTCCATATGTTCACCGTTACGGCAATCTACGCAATGTTTCGCTTGAGAAAATAAGACCGATCGGTTTGTGAGCGGATGAAAACGGAAAACGGAAAAAAGTTTAACTGTAGTTTATGCCGAGAATGTCGGGATGTTGGAAAAGTTAAGGACCCAACACATCTGGATATGACTTGCGCAGCTGATTTCTCTATTGCCGCCCGTTATGAGAATACACTTCTATGTTTGAGTAATGAGAAACAAGTTTTACAAACAGATGAAGATTGATCAACTTGATTCGTGAGTGAAAGCAAAACGAAAACCAGACATGAAGGCTTCAGTGATGCTCGCAGTGCTGTTTGTTTTGGTGTATTCTGGAAGCTATGCAACAACTGCAGatcaTCTTATGGAGACTTCTACTCTAAAGAATGATGAAAGCAGTTTACAGTGCAGTTGTGAGAACacaaacttgtgtgaaaacaacagCTGCTGGGGTCGTATCTGCTTTTACACTTCGGTCCATGAGCGGGTTGTCAGGGGCTGTTTTCAGACCGCCGAACAGTGCTACGTACCTGCTATTCCTGGAGTTTATACCAAATGCTGCTACACACACCACTGCAATGCAAACCTTACCATGCCTGAAAAACCAGTGGAGAAGCCCATCAGAGTGATTCTGCTGGTTGGAGTGCCGTTGCTGGTGTTGTTGGTGATTGCCATGGCAGCTTGTGGACTTGTGTTATGGCTGCGTACAAGACGTCAATACTGCCATCCGGTTGAGCACGATACCTCCATGCTTAAAGTCCCCAGTGGAGGAGACCCCACATATGGGGATATCTTTGATGAGTTTTGTACATCGGGCAGTGGCACTGGTCTGCCCTATCTGGTGCAGAGGACCATGGCGCGACAGATCTCTCTGGTTGAGTGTGTTGGTAAAGGCCGTTATGGTGAGGTATGGAGAGGCACCTGGATGGGAGAAAGTGTGGCTGTCAAGATTTTCTCCTCTCGTGATGAGCAGTCTTGGTTTCGAGAGACTGAAATCTACAACACGGTCCAACTAAGGCATGAAAACATCTTGGGCTTCATAGCATCAGACATGACGTCTAAAAACTCCAGCACTCAACTGTGGCTGGTCACACATTTCCACGAGTTGGGCTCCCTCTATGACTTCCTGCAGTACAGCACGCTGGACCCGGAGGGCTGTCTGCGCATGTGCCTGTCCATCGCCAGCGGCCTCGTGCACCTCCACACAGAGATCCTCAGCACACAAGGCAAACCAGCCATCGCACACAGAGACCTGAAGAGCCGCAATATTCTGGTGAAGAGAAATGGCCAGTGCTGCATTGCAGACCTGGGCCTGGCTGTCATTCACTCTCAGTCTACTGACTATCTGGATGTGGGAACCAATCCGAGAGTGGGCACCAAGCGATACATGGCACCAGAGGTTTTGGATGAGACTATTCGTGTTGATGTTTTTGAGTCCTATAAACAAACTGACATCTGGGCCCTGGGTCTCGTCTTGTGGGAGATAACTCGTCGGACTATTGTAAATGGAATCGTGGAGGAGTACAGGCCGCCGTTCTTTGACATGGTGCCCTCTGACCCCAGTTTTGAGGAGATGAAGAAAGTGGTGTGTGTGGACCAGCACAGGCCCAGTCTCCACAATCGACTACACTCTCATCCGatcCTGTCTGCGATTGCAAAGATTATGAAAGAATGCTGGTTCCAAAGCCCTTCAGCCCGACTCACTGCTCTGCGCGTGCGAAAGAGCCTCTCCAAACTGGACCAGGACCATGACTACGACATAGACAAGCTTAAACTGGACCTCTAGAATAGACATGCTACCAATGCATTTCAATAGACACTCAATTGTAAGGGCCACATGACACATCTTATCCTTTTGAACTCTTCTACTGTGCCTTTCAGCTTCTTGTCCTTAGGCTCCACCGAACATATTTTATCATGACATTCGTTCTCTGTGGGAAGTTGACTGTGCTGTTAAATTTCTCCTCAAATATATCCACTGCTCTTCCAGGACCTGTATATTTCAACAGAGTGACTCATTTGTTACTGAAAGTGGTAAACCCACTAAATACTTGTTAGTAAAGTGAGGGTAAGATGGGGTTTTTTAGACAGGATGTGGGTTATTGTGGACTTCCTAACTGCGGCATTTCCTGAAATTTCTTACTTCCTAAACATGACTGTTACGCAGAGAGTTTGGCACAAGCTTATTTGCACTTATAGCTTGTTTTTTGGTTCCAAGAAAGACTTGAACCAGCTTTTTAGGAACAAGAACTGCATTACAGCTCGCACCAAGTAATCATTAAAGAGAACATATTAGTATAGTGCActtttataaacagttttttaatGCAAGATTAATGTTATAATCATACTGGCTGTACTATATCTTTTTtgttataaagtaaaaaaaaaatttaaatatatttgctttGTGAAATATTCGAAACAAAAatgtgtataatttttttttgcgcACAAAATGTCTTATTTTCACTCAGAGAatagtatttaattattaataaagccTGATAAAAAA
>TCONS_00044228
AAAAAAACAGACGTGGAAAAAATGAAAGGTCTTGCAGCAACAGGAAAACAGCTATGAGACCGCATTCCTAGTGAACCCCGGCTTAGACAATGAGAGACATGAAGGCTTCAGTGATGCTCGCAGTGCTGTTTGTTTTGGTGTATTCTGGAAGCTATGCAACAACTGCAGatcaTCTTATGGAGACTTCTACTCTAAAGAATGATGAAAGCAGTTTACAGTGCAGTTGTGAGAACacaaacttgtgtgaaaacaacagCTGCTGGGGTCGTATCTGCTTTTACACTTCGGTCCATGAGCGGGTTGTCAGGGGCTGTTTTCAGACCGCCGAACAGTGCTACGTACCTGCTATTCCTGGAGTTTATACCAAATGCTGCTACACACACCACTGCAATGCAAACCTTACCATGCCTGAAAAACCAGTGGAGAAGCCCATCAGAGTGATTCTGCTGGTTGGAGTGCCGTTGCTGGTGTTGTTGGTGATTGCCATGGCAGCTTGTGGACTTGTGTTATGGCTGCGTACAAGACGTCAATACTGCCATCCGGTTGAGCACGATACCTCCATGCTTAAAGTCCCCAGTGGAGGAGACCCCACATATGGGGATATCTTTGATGAGTTTTGTACATCGGGCAGTGGCACTGGTCTGCCCTATCTGGTGCAGAGGACCATGGCGCGACAGATCTCTCTGGTTGAGTGTGTTGGTAAAGGCCGTTATGGTGAGGTATGGAGAGGCACCTGGATGGGAGAAAGTGTGGCTGTCAAGATTTTCTCCTCTCGTGATGAGCAGTCTTGGTTTCGAGAGACTGAAATCTACAACACGGTCCAACTAAGGCATGAAAACATCTTGGGCTTCATAGCATCAGACATGACGTCTAAAAACTCCAGCACTCAACTGTGGCTGGTCACACATTTCCACGAGTTGGGCTCCCTCTATGACTTCCTGCAGTACAGCACGCTGGACCCGGAGGGCTGTCTGCGCATGTGCCTGTCCATCGCCAGCGGCCTCGTGCACCTCCACACAGAGATCCTCAGCACACAAGGCAAACCAGCCATCGCACACAGAGACCTGAAGAGCCGCAATATTCTGGTGAAGAGAAATGGCCAGTGCTGCATTGCAGACCTGGGCCTGGCTGTCATTCACTCTCAGTCTACTGACTATCTGGATGTGGGAACCAATCCGAGAGTGGGCACCAAGCGATACATGGCACCAGAGGTTTTGGATGAGACTATTCGTGTTGATGTTTTTGAGTCCTATAAACAAACTGACATCTGGGCCCTGGGTCTCGTCTTGTGGGAGATAACTCGTCGGACTATTGTAAATGGAATCGTGGAGGAGTACAGGCCGCCGTTCTTTGACATGGTGCCCTCTGACCCCAGTTTTGAGGAGATGAAGAAAGTGGTGTGTGTGGACCAGCACAGGCCCAGTCTCCACAATCGACTACACTCTCATCCGatcCTGTCTGCGATTGCAAAGATTATGAAAGAATGCTGGTTCCAAAGCCCTTCAGCCCGACTCACTGCTCTGCGCGTGCGAAAGAGCCTCTCCAAACTGGACCAGGACCATGACTACGACATAGACAAGCTTAAACTGGACCTCTAGAATAGACATGCTACCAATGCATTTCAATAGACACTCAATTGTAAGGGCCACATGACACATCTTATCCTTTTGAACTCTTCTACTGTGCCTTTCAGCTTCTTGTCCTTAGGCTCCACCGAACATATTTTATCATGACATTCGTTCTCTGTGGGAAGTTGACTGTGCTGTTAAATTTCTCCTCAAATATATCCACTGCTCTTCCAGGACCTGTATATTTCAACAGAGTGACTCATTTGTTACTGAAAGTGGTAAACCCACTAAATACTTGTTAGTAAAGTGAGGGTAAGATGGGGTTTTTTAGACAGGATGTGGGTTATTGTGGACTTCCTAACTGCGGCATTTCCTGAAATTTCTTACTTCCTAAACATGACTGTTACGCAGAGAGTTTGGCACAAGCTTATTTGCACTTATAGCTTGTTTTTTGGTTCCAAGAAAGACTTGAACCAGCTTTTTAGGAACAAGAACTGCATTACAGCTCGCACCAAGTAATCATTAAAGAGAACATATTAGTATAGTGCActtttataaacagttttttaatGCAAGATTAATGTTATAATCATACTGGCTGTACTATATCTTTTTtgttataaagtaaaaaaaaaatttaaatatatttgctttGTGAAATATTCGAAACAAAAatgtgtataatttttttttgcgcACAAAATGTCTTATTTTCACTCAGAGAatagtatttaattattaataaagccTGAT

Function


symbol description
acvrl1 Predicted to enable SMAD binding activity and transforming growth factor beta receptor activity, type I. Acts upstream of or within several processes, including artery morphogenesis; blood vessel endothelial cell migration; and determination of ventral identity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of BMP receptor complex. Predicted to be active in plasma membrane. Is expressed in cardiovascular system and liver. Used to study arteriovenous malformation. Human ortholog(s) of this gene implicated in hereditary hemorrhagic telangiectasia and pulmonary hypertension. Orthologous to human ACVRL1 (activin A receptor like type 1).

GO:

id name namespace
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway biological_process
GO:0007179 transforming growth factor beta receptor signaling pathway biological_process
GO:0007507 heart development biological_process
GO:0048514 blood vessel morphogenesis biological_process
GO:0071363 cellular response to growth factor stimulus biological_process
GO:0001525 angiogenesis biological_process
GO:0048264 determination of ventral identity biological_process
GO:0030509 BMP signaling pathway biological_process
GO:0048844 artery morphogenesis biological_process
GO:0006468 protein phosphorylation biological_process
GO:0001568 blood vessel development biological_process
GO:0009953 dorsal/ventral pattern formation biological_process
GO:0097746 blood vessel diameter maintenance biological_process
GO:0016310 phosphorylation biological_process
GO:0001944 vasculature development biological_process
GO:0034405 response to fluid shear stress biological_process
GO:0060840 artery development biological_process
GO:0043534 blood vessel endothelial cell migration biological_process
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0070724 BMP receptor complex cellular_component
GO:0043235 receptor complex cellular_component
GO:0016740 transferase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0046332 SMAD binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0004675 transmembrane receptor protein serine/threonine kinase activity molecular_function
GO:0016301 kinase activity molecular_function
GO:0005025 transforming growth factor beta receptor activity, type I molecular_function

KEGG:

id description
ko04060 Cytokine-cytokine receptor interaction
ko01001 Protein kinases

ZFIN:

id description
ZDB-GENE-021003-1 Predicted to enable SMAD binding activity and transforming growth factor beta receptor activity, type I. Acts upstream of or within several processes, including artery morphogenesis; blood vessel endothelial cell migration; and determination of ventral identity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of BMP receptor complex. Predicted to be active in plasma membrane. Is expressed in cardiovascular system and liver. Used to study arteriovenous malformation. Human ortholog(s) of this gene implicated in hereditary hemorrhagic telangiectasia and pulmonary hypertension. Orthologous to human ACVRL1 (activin A receptor like type 1).

Ensembl:

ensembl_id ENSDARG00000018179

RNA


RNA id representative length rna type GC content exon number start site end site
TCONS_00044227 False 2794 mRNA 0.44 11 27835647 27857051
TCONS_00044228 True 2321 mRNA 0.45 11 27835653 27857104
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Neighbor


gene id symbol gene type direction distance location
XLOC_022418 acvr1ba coding downstream 12727 27800519 ~ 27822920 (-)
XLOC_022417 NA coding downstream 39724 27788369 ~ 27795923 (-)
XLOC_022416 NA coding downstream 63275 27770481 ~ 27772372 (-)
XLOC_022415 NA coding downstream 106193 27727295 ~ 27729454 (-)
XLOC_022414 dnajc22 coding downstream 133086 27696694 ~ 27702561 (-)
XLOC_022420 ankrd33aa coding upstream 5703 27862807 ~ 27875140 (-)
XLOC_022421 sp5l coding upstream 165987 28023091 ~ 28025943 (-)
XLOC_022422 b4galnt1a coding upstream 240178 28097282 ~ 28123767 (-)
XLOC_022423 tac3a coding upstream 282385 28139489 ~ 28141419 (-)
XLOC_022424 znf385a coding upstream 328779 28185883 ~ 28294763 (-)
XLOC_022412 NA non-coding downstream 160253 27652896 ~ 27675394 (-)
XLOC_022408 CR354381.1 non-coding downstream 255355 27580164 ~ 27580292 (-)
XLOC_022427 NA non-coding upstream 576071 28433175 ~ 28453703 (-)
XLOC_022432 CR677617.1 non-coding upstream 1328748 29185852 ~ 29257716 (-)
XLOC_022433 NA non-coding upstream 1476749 29333853 ~ 29358214 (-)
XLOC_022440 NA non-coding upstream 1817891 29674995 ~ 29706359 (-)
XLOC_022443 NA non-coding upstream 1964097 29821201 ~ 29822565 (-)

Expression


Expression of XLOC_022419(acvrl1) in the Zebrafish Sample from each Developmental Stage of PRJEB12982

Boxplot with 18 boxes. Box plot charts are typically used to display groups of statistical data. Each data point in the chart can have up to 5 values: minimum, lower quartile, median, upper quartile, and maximum.
The chart has 1 X axis displaying categories.
The chart has 1 Y axis displaying Expression. Range: 0 to 20.
End of interactive chart.

Expression of XLOC_022419(acvrl1) in the Zebrafish Sample of PRJEB12982

Bar chart with 360 bars.
The chart has 1 X axis displaying categories.
The chart has 1 Y axis displaying Expression. Range: 0 to 20.
End of interactive chart.

Co-expression Network


Homologous


species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000001_10658398_10672912 ACVRL1 coding CI01000001 null 10658392 ~ 10673477 (-)