XLOC_024433 (drd4a)


Basic Information

Item Value
gene id XLOC_024433
gene name drd4a
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007136.7
NCBI id CM002909.2
chromosome length 37502051
location 4707173 ~ 4733221 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00048293
CAGGTTCATCGCCGTCTCCATCCCTCTAAATTACAACCGCAAACACGTGGACCAGCGACAGATTGTCCTGCTCTCCGCCACGTGGATCCTGGCCTTAGCCGTGGCCTCCCCCGTGATGTTCGGCATCAACAACGTCCCCAACCGGGACCACAGCGAATGCAAGCTGGAGGACAACAACTACGTTATCTACTCCTCCGTCTGTTCGTTTTTCGTGCCGTGCCCCATCATGCTGCTCCTGTACTGCGGAATGTTCCGGGGCCTGAGGAACTGGGAAGAGGCTCGGAAAGCTAAATTAAGGAGCAACATGGAGGCCTGCCGAAAGCTTCAGGAGGCCGCAGCGTCGCTCCAGCCGCTGTCTGGCCTGCCGCCGCCGCTCCCGCCTGTTATAGAGAAAGACATTACATTGGAGGAGCTGGACCAAGATCACTATCCCGATCCCGACAGTCCTGATCCTGTGTCCATGTTGGCGTATCCTGGAGGAGGCTACAATCAGGATCAAAACCAGAACCGGCAACGGAAGCGGGCCAAGATCAACGGCAGAGAGAGGAAAGCCATGAGGGTGCTTCCGGTTGTAGTAGGTGCCTTCCTGTTCTGCTGGACACCATTCTTCGTAGTGCACACTATGAGGGCTCTCTGCGAAGACTGCGAAATTCCTGGCAGCGTCACCAGTATCGTGACCTGGTTGGGTTATGTCAACAGCGCCATCAACCCAATCATCTACACCGTCTTTAACACGGAGTTCAGGAAGTTCTTTCGGAAGTTTCTGCCGACGCTGCCTGGCTGCTGCTAGCCTGAGCATGCTAAAAGGGTTTACGAACAAAACAtacccaaaaaatgtgtaaataaacaagAACTAAAAACGTTTGCGTGTAAATACAGCATGTTGTGAGATAATAATGCACTAAGATGTTTGCTGCCATTACGTGTTTactgtgtgttttaattttgtaTGTTTACATTTCAAGAGCTGACATCAAAGGGCCTTATTTAAGAAACACAAGCAGAGTGAAATGCGTAAATCACGCGTGAATTCATGAAATGATTGTATTGTAAAAGGCGCGTTCACAATGTATTTTGCTGTTCACTTATCCAACAATGGTGTTTTTATGGTTTGCAAATGCAAAATTTTGAAAACAATTGTTATTGTCGCTACAAAAATGTGAGTTTTGGAAAACTTTCACTACATGCAGTGACATCGCCATCTACTGGTATACCATACAAAATACAATGTGTTTGTCTGCAAATTTTTGAAAAACAATTGTGTTATCGGCGCCACAAAAACTTGATTTTGTGAAAAAAGTCACTACATGCATAGTGACATCGCCACCTACTGGTATAGCATACAAAGTACAATGTTTTTGTAGGCAAATTTTTGAAAACAATTGTGTTATTGGCATCACAAAAACTTGATTTTGTGAAAAATGTCACTACATGCATAGTGACATCGCCACCTACTGGTATAGCATACAAAATACGTTTTTGTCGGCAAATTTTTGAAAACAATTGTGTTATCGGCGCCACAAAAACTTGATTTTGTGAAAAAAGTCACTACATGCATAGTGACATCGCCACCTACTGGTATAGCATACAAAGTACAATATTTTTGTATGCAAATTTTTGAAAACAATTGTGGTATTGGCGCCACAAGAACTAGATTCTGTGAAAAATGTCACTACATGCACAGTTACATCACCATCTACTGGTATAGCATGCAAAATACAGTGCTTTTGTCGGCAAATTTTTTGAAAACAATTGTGTTTTCTGCACCGCAAAAACTTAATTTTGTGAAAAATGTCATTGCATTTACAGTGATACACCATCTTCTGGTATAGCATGCAAAATACAATGTTTTTGTGTGCAAATTTTGGAAAACAATTGTGTTATCGGCGCCACAAAAACTAGATCTTGTGAAAATTTTCTCTACGTGCACAGTGACGTCGCCATCTACTGGTATAGCATGCAAAATACAGTGCTTTTGTATGCAATTTTTTGAGAACAACTGTGTTATCGGCACCACAATAACTTGATTTTGTGAAAACTTTCTCCACGTGCACAGTGACATCGCCATCTACTGGTATTGCTtccaaaatttttaaaaacatttgcggTATTGGCGCCACAAAAAATagattctgtaaaaaaaaaaaaaaaa
>TCONS_00048294
GAAAACTTTTGCGTCGAAAAACACCGAATGAACAGCGATGATTTTACCACTTGCAACCACATTCAGCCTCTTTCCCATCTCACAGACTGAAAACAACAGTACTGGGCTCCGGAAAGCGCAGAGTTCAGCGGGACGCTCGGAGTTTGGAGAGACGCTCAAATAATGGCAAAGAAGAAACGGGCTTTTTTTCTCCAAGGATTTCCAGATGACAGGTTATGGTAGAGGCAGACATGCCAGCCAACCTCACCATCTCCACCCACACCACGAACTACAACTTCCCAGCGCTCATCTTCGGGATATTACTGATCATAATCATCATTTGCGGGAACGTGCTGGTGTGTCTGAGTGTTTACACGGAGAAAGCGCTGAAAACCACCACCAACTACTTCATAGTCAGTTTGGCTGTGGCTGATCTGCTGTTAGCTGTGCTGGTCTTACCGCTGTTTGTGTATGCGGAGtttcaGGATGGAGTTTGGTCCCTCAATATGACCGTATGTGATGGACTGATGACCATGGATGTCATGCTTTGCACTGCCTCAATATTTAACCTCTGCGCCATCAGCATAGACAGGTTCATCGCCGTCTCCATCCCTCTAAATTACAACCGCAAACACGTGGACCAGCGACAGATTGTCCTGCTCTCCGCCACGTGGATCCTGGCCTTAGCCGTGGCCTCCCCCGTGATGTTCGGCATCAACAACGTCCCCAACCGGGACCACAGCGAATGCAAGCTGGAGGACAACAACTACGTTATCTACTCCTCCGTCTGTTCGTTTTTCGTGCCGTGCCCCATCATGCTGCTCCTGTACTGCGGAATGTTCCGGGGCCTGAGGAACTGGGAAGAGGCTCGGAAAGCTAAATTAAGGAGCAACATGGAGGCCTGCCGAAAGCTTCAGGAGGCCGCAGCGTCGCTCCAGCCGCTGTCTGGCCTGCCGCCGCCGCTCCCGCCTGTTATAGAGAAAGACATTACATTGGAGGAGCTGGACCAAGATCACTATCCCGATCCCGACAGTCCTGATCCTGTGTCCATGTTGGCGTATCCTGGAGGAGGCTACAATCAGGATCAAAACCAGAACCGGCAACGGAAGCGGGCCAAGATCAACGGCAGAGAGAGGAAAGCCATGAGGGTGCTTCCGGTTGTAGTAGGTGCCTTCCTGTTCTGCTGGACACCATTCTTCGTAGTGCACACTATGAGGGCTCTCTGCGAAGACTGCGAAATTCCTGGCAGCGTCACCAGTATCGTGACCTGGTTGGGTTATGTCAACAGCGCCATCAACCCAATCATCTACACCGTCTTTAACACGGAGTTCAGGAAGTTCTTTCGGAAGTTTCTGCCGACGCTGCCTGGCTGCTGCTAGCCTGAGCATGCTAAAAGGGTTTACGAACAAAACAtacccaaaaaatgtgtaaataaacaagAACTAAAAACGTTTGCGTGTAAATACAGCATGTTGTGAGATAATAATGCACTAAGATGTTTGCTGCCATTACGTGTTTactgtgtgttttaattttgtaTGTTTACATTTCAAGAGCTGACATCAAAGGGCCTTATTTAAGAAACACAAGCAGAGTGAAATGCGTAAATCACGCGTGAATTCATGAAATGATTGTATTGTAAAAGGCGCGTTCACAATGTATTTTGCTGTTCACTTATCCAACAATGGTGTTTTTATGGTTTGCAAATGCAAAATTTTGAAAACAATTGTTATTGTCGCTACAAAAATGTGAGTTTTGGAAAACTTTCACTACATGCAGTGACATCGCCATCTACTGGTATACCATACAAAATACAATGTGTTTGTCTGCAAATTTTTGAAAAACAATTGTGTTATCGGCGCCACAAAAACTTGATTTTGTGAAAAAAGTCACTACATGCATAGTGACATCGCCACCTACTGGTATAGCATACAAAGTACAATGTTTTTGTAGGCAAATTTTTGAAAACAATTGTGTTATTGGCATCACAAAAACTTGATTTTGTGAAAAATGTCACTACATGCATAGTGACATCGCCACCTACTGGTATAGCATACAAAATACGTTTTTGTCGGCAAATTTTTGAAAACAATTGTGTTATCGGCGCCACAAAAACTTGATTTTGTGAAAAAAGTCACTACATGCATAGTGACATCGCCACCTACTGGTATAGCATACAAAGTACAATATTTTTGTATGCAAATTTTTGAAAACAATTGTGGTATTGGCGCCACAAGAACTAGATTCTGTGAAAAATGTCACTACATGCACAGTTACATCACCATCTACTGGTATAGCATGCAAAATACAGTGCTTTTGTCGGCAAATTTTTTGAAAACAATTGTGTTTTCTGCACCGCAAAAACTTAATTTTGTGAAAAATGTCATTGCATTTACAGTGATACACCATCTTCTGGTATAGCATGCAAAATACAATGTTTTTGTGTGCAAATTTTGGAAAACAATTGTGTTATCGGCGCCACAAAAACTAGATCTTGTGAAAATTTTCTCTACGTGCACAGTGACGTCGCCATCTACTGGTATAGCATGCAAAATACAGTGCTTTTGTATGCAATTTTTTGAGAACAACTGTGTTATCGGCACCACAATAACTTGATTTTGTGAAAACTTTCTCCACGTGCACAGTGACATCGCCATCTACTGGTATTGCTtccaaaatttttaaaaacatttgcggTATTGGCGCCACAAAAAATagattctgt
>TCONS_00048295
AAGACGAGCTCTGATCCTCTTCACGGCTTCTTGTGAGACGTGTCACAGACGTGCTTGTACTTTGCTAACCACACGTCAATCCCTTTCAGCCCATGTCAGCTTGAGGACAGACCAGAAagaggGTGCCTTCCTGTTCTGCTGGACACCATTCTTCGTAGTGCACACTATGAGGGCTCTCTGCGAAGACTGCGAAATTCCTGGCAGCGTCACCAGTATCGTGACCTGGTTGGGTTATGTCAACAGCGCCATCAACCCAATCATCTACACCGTCTTTAACACGGAGTTCAGGAAGTTCTTTCGGAAGTTTCTGCCGACGCTGCCTGGCTGCTGCTAGCCTGAGCATGCTAAAAGGGTTTACGAACAAAACAtacccaaaaaatgtgtaaataaacaagAAC

Function

symbol description
drd4a Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Acts upstream of or within spinal cord motor neuron cell fate specification and ventral spinal cord interneuron differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Orthologous to human DRD4 (dopamine receptor D4).

GO:

id name namespace
GO:0051967 negative regulation of synaptic transmission, glutamatergic biological_process
GO:0007186 G protein-coupled receptor signaling pathway biological_process
GO:0043266 regulation of potassium ion transport biological_process
GO:0007194 negative regulation of adenylate cyclase activity biological_process
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway biological_process
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway biological_process
GO:0051481 negative regulation of cytosolic calcium ion concentration biological_process
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway biological_process
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway biological_process
GO:1901386 negative regulation of voltage-gated calcium channel activity biological_process
GO:0014059 regulation of dopamine secretion biological_process
GO:0007165 signal transduction biological_process
GO:0001963 synaptic transmission, dopaminergic biological_process
GO:0021514 ventral spinal cord interneuron differentiation biological_process
GO:0021520 spinal cord motor neuron cell fate specification biological_process
GO:0005887 integral component of plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0004930 G protein-coupled receptor activity molecular_function
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go molecular_function
GO:0004952 dopamine neurotransmitter receptor activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-070112-996 Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Acts upstream of or within spinal cord motor neuron cell fate specification and ventral spinal cord interneuron differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Orthologous to human DRD4 (dopamine receptor D4).

Ensembl:

ensembl_id ENSDARG00000038363

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00048293 False 2152 mRNA 0.42 2 4707173 4717462
TCONS_00048294 False 2704 mRNA 0.44 4 4707189 4733221
TCONS_00048295 True 398 mRNA 0.49 2 4708471 4713461

Neighbor

gene id symbol gene type direction distance location
XLOC_024432 NA coding downstream 128709 4570228 ~ 4578464 (-)
XLOC_024431 pidd1 coding downstream 177088 4507288 ~ 4530085 (-)
XLOC_024430 slc25a22a coding downstream 224667 4460039 ~ 4482506 (-)
XLOC_024429 FO907094.1 coding downstream 381442 4325616 ~ 4325731 (-)
XLOC_024428 syt7a coding downstream 393474 4231238 ~ 4313699 (-)
XLOC_024434 cyp19a1b coding upstream 157546 4890767 ~ 4904432 (-)
XLOC_024435 NA coding upstream 197144 4930365 ~ 4931600 (-)
XLOC_024436 shisal1b coding upstream 364841 5098062 ~ 5189989 (-)
XLOC_024437 NA coding upstream 563211 5296432 ~ 5300492 (-)
XLOC_024438 CABZ01039859.2 coding upstream 607741 5340962 ~ 5341102 (-)
XLOC_024427 NA non-coding downstream 511830 4194792 ~ 4195343 (-)
XLOC_024425 NA non-coding downstream 535416 4168932 ~ 4171757 (-)
XLOC_024421 NA non-coding downstream 822743 3880722 ~ 3884430 (-)
XLOC_024439 NA non-coding upstream 733272 5466493 ~ 5466809 (-)

Expression


Co-expression Network