XLOC_002474 (hlcs)


Basic Information

Item Value
gene id XLOC_002474
gene name hlcs
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007121.7
NCBI id CM002894.2
chromosome length 45420867
location 53587 ~ 57270 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00004634
ATCAATTTCAGCTTTAATAAAACGACGACTGTTTTTCTGTTCAGTGAAATATATAagcatgtataatatatataatgatgcgtgtgcatgtgtgctcCAGGTGCTGAACTGGTCTGACCTGTGTCTCCCGCTGGCGTGCAGTCCAGGTCAGCCGTACCGGGCCGTAGCAGAAACCAGCCTGGAGAACTTCAGCCGCCTCGGCGTGGCTTTCATGGAGGATCGTCTGCGCATGGAGAACGGGCTCATACCTGCCAAGATCACCTCCGTGTCCCTCAGAGAAGCAGCGCTGCAGGAGCTGATCCAGAGTCAGCAGAGGAGACGCCTCAGTGCCCCGCAGCAGCACCCCGAGCCACAATCCGAGCACCAGCACATGGACGGACACCACCTGCACCTGTCCAGCTGCACCGAGTGCCTGGAGCTGGAGAACAGCACCATCCTGTCAGTGCGGTGCGCCTCCGTGGAGAACATCCCGGACCTGCCGGAGGACTGCAGCACTGAGCCGGAGCAGGAGCCGGGACCACAGTGTGCGCATGGGAAGCCCCCCAATGTGCTGGTGTATACGGACGGCTGTGAGCAGCAGTTCCAGAAGATCCGCTCGCTGCTGGCGGAGTGTGTGGACACTGAGCGCTACACCGTGTACCACCTGCAGCCGCAGCAGGCGCTGAGCGAGCCTTGGCTGGAGAACACCCTGCTGCTGGTGCTGGCCCCCGAACACCCAGTCCCGCTCCCGCCGCCGCTGCAGCTGCGCTTCCTGTCCTACCTGAGCCAGGGCGGGCGTCTGCTGGGGCTGTGCTGCTCCCTGTGCCCCGCCGGCCTCACCCTGCGGCCTCGGGCCCCACCGCACCCGCAGCTCTGCACGCTGAGCTTCACCCGGGCGGACAGCAGCCAGCTGCGGCTCAGCGTGGTGTCCAGCGGGAGCGTGTTCGAGCGGGATGGAGGTGGCGGCGGGCAGGTGGAGCTGTGGGGGCAGATCAGCGGGCAGGAGATGGCCATCGTCAGGGTCACACACGGGCCCGACAGCGGAGAGGCCATTCTCTGTCAGGTGCGTCTGGACTCTGCTCCAGCTCCTCATCACCTGTCGGGCACCCAGAGCTGCTCTGAGCTGGAGACGAGCGACGCCCTGCGCTACCAGGTGCTGACGGAGATCCTGACCTCTCTGGGACTGAGCTGTGGGCGGAGCCAGGTGCTGCCGCACACCCCCATACACCTGCTGACCACACACCCGgaGCTGAAGGCCAGTTTCGTGCGCTGGCTGCGTGCTCAGGTGTGTGTGTCCGGGGGTGTTGTGCGTCTGCCGGAGTGTGTGTTGAAGGTGTGCTGGTCAGCGCAGGAGTGTGTGGAGGTGTGTGACGGAGAGCTGGTCTTACACACTGACCCGCCCGCGTGTTTCTCTGAGCTCTTCAGCCTGCAGACATACACACACCACCTGCAGACGCAGCGGCTCGGGCGCACCGTCCTCTACACTGACGTCACATCCTCCACCATGGACCTGCTGGACGGGTAGGggaggcgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgattgttcaGACTGTATGTGTGCAAAGAGGGTTGTGTgcagatagtgtgtgtgtgtg

Function

symbol description
hlcs Predicted to enable biotin-[acetyl-CoA-carboxylase] ligase activity. Predicted to be involved in histone biotinylation. Predicted to act upstream of or within cellular protein modification process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase).

GO:

id name namespace
GO:0009305 protein biotinylation biological_process
GO:0071110 histone biotinylation biological_process
GO:0006464 cellular protein modification process biological_process
GO:0005737 cytoplasm cellular_component
GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity molecular_function

KEGG:

id description
ko00780 Biotin metabolism

ZFIN:

id description
ZDB-GENE-030131-5333 Predicted to enable biotin-[acetyl-CoA-carboxylase] ligase activity. Predicted to be involved in histone biotinylation. Predicted to act upstream of or within cellular protein modification process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase).

Ensembl:

ensembl_id ENSDARG00000039934

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00004634 True 1642 mRNA 0.62 4 53587 57270

Neighbor

gene id symbol gene type direction distance location
XLOC_002473 NA coding downstream 1613 48851 ~ 51974 (-)
XLOC_002472 CABZ01064670.1 coding downstream 8101 32901 ~ 45486 (-)
XLOC_002471 NA coding downstream 22757 30306 ~ 30830 (-)
XLOC_002475 dyrk1aa coding upstream 5099 62369 ~ 76367 (-)
XLOC_002476 ttc3 coding upstream 24627 81897 ~ 108952 (-)
XLOC_002477 ripply3 coding upstream 58845 116115 ~ 120580 (-)
XLOC_002478 KCNJ6 coding upstream 67725 124995 ~ 135432 (-)
XLOC_002479 erg coding upstream 104390 161660 ~ 175562 (-)
XLOC_002480 NA non-coding upstream 122593 179863 ~ 180704 (-)
XLOC_002487 CABZ01049604.1 non-coding upstream 282642 339912 ~ 340027 (-)
XLOC_002488 NA non-coding upstream 296823 354093 ~ 354657 (-)
XLOC_002489 NA non-coding upstream 299285 356555 ~ 358707 (-)
XLOC_002491 NA non-coding upstream 358727 415997 ~ 421653 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) G388201 NA non-coding CI01000203 null 74382 ~ 78575 (+)
bowfin (Amia calva) AMCG00016271 NA coding CM030122.1 CM030122.1 14270317 ~ 14282590 (+)