XLOC_024886 (wwox)


Basic Information

Item Value
gene id XLOC_024886
gene name wwox
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007136.7
NCBI id CM002909.2
chromosome length 37502051
location 36960724 ~ 37071036 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00048967
CCTGCGGCTCTCGGCTCCGGCACGGGTCGTGGTGGTTTCCTCCGAGTCCCACAGGTTCACAGATCTGCTGGACTCGTGTGGGAATCTGGATCTGGATCTGCTGTCTCCTCCACAGAAGAACTACTGGTCTCTGCTGGCCTACAACCGAGCCAAACTCTGCAACCTGCTGTTCTCCAGCGAGCTGCACCGCCGCATGTCCCCGCACGGCATCTGCTGCAACGCTCTGCATCCCGGAAACATGATGTTCACCTCCATCCACCGCAGCTGGTGGCTCCTCACGCTGCTCTTCAGCCTCGCGAGACCCTTCACCAAGTCCATGtatCTCCTCCTCATCTGTAATCTGTGTTCTGCAGTCCAACATTAGACTCATGCTGATCTGCAGATGACTTCAGCTTTGATAAGGCTGCACTCATTTTCTCATTTTCTCCTGGTAATGATGGAGTGGTCTCTGGTGCTCCACATCATGTCAGCGCACAGCAGGAGGCCAAATATTTAGGCTTTATTTcaatcatgtaaaaaaaaaaaaactgtgatattAATA
>TCONS_00048968
cgttaataaaatactattaatgtctaatttaataaataaaatcaataatactcggtataattacagtttttacattactgtgatggtttggtttagggttaaGGTAGGGgttgacgttaataaaatacaactaatgggtaatttaataaaaaataggtaAAACACTCGTTAACCTCCATCCGCGGCTGTATCCCTTCTAACAACACCCGCTAAACTCCGCCCACTCGAGGACCGCGTGCCGTTACTCCGCCTCTTAGTGGCGTCAGGTTGTGATTGCGGAAGTGCCCTGTCAGGATTATTGTAACGCGTGTGTGCGCGCTGCCAAACAAACACCTCACAGAAGTTAAAGAGATTTATTAGCGTGGAAATTCAATAATTTCGCAATGGCGGCTCTCAAATACGCCGGAATGGAGGATACAGACAGCGAAGACGAGCTACCGCCGGGCTGGGAGGAGAGGTCCACCAAAGACGGATGGGTTTATTACGCTAATCATGAGGAGATGAAGACCCAGTGGGAGCATCCCAAAACCGGCAAGAAGAAACGCTGTGCTGGAGCTTTGCCATACGGATGGGAGCAGGAGACCGATGATAAAGGCCAAATCTTCTATGTGGATCACATCAACAAGCGTAAGACGTATTTCGACCCTCGGCAGGCCTTCACTGTAGAGGACATGCAGGTGAAGCCTAAACGCTACGACGGAAACACCGGCGCTCTGGAGATCCTGCATGGCCAGGACCTGTCCGACAAGGTCATCATCGTCACCGGAGCCAACTCTGGCATCGGTTTCGAGACGGCGCGATCCTTTGCTCTTCACGGCGCGCATGTGATCTTAGCCTGCCGGAACCAAAGCCGAGCCAGTAAAGCAGCCAGTCTGATCATGGGCGAATGGAGCAAAGCCCGTGTGGAAGTTTTACCGCTGGATTTGGCATCTCTGAGGAGCGTCCGACAGTTCGCAGAGCTCTTCAAAGCCACAAAACTGCCTCTGCATGTGCTGGTGTGTAACGCTGCCGTCTGCTCACAGCCCTGGCGTCTGACGGAGGACGGGTTCGAATCCACCTTTCAGATCTGCCACCTGGGCCACTTCCTCCTGGTGCAGCTCCTGCAGGACGTCCTGCGGCTCTCGGCTCCGGCACGGGTCGTGGTGGTTTCCTCCGAGTCCCACAGGTTCACAGATCTGCTGGACTCGTGTGGGAATCTGGATCTGGATCTGCTGTCTCCTCCACAGAAGAACTACTGGTCTCTGCTGGCCTACAACCGAGCCAAACTCTGCAACCTGCTGTTCTCCAGCGAGCTGCACCGCCGCATGTCCCCGCACGGCATCTGCTGCAACGCTCTGCATCCCGGAAACATGATGTTCACCTCCATCCACCGCAGCTGGTGGCTCCTCACGCTGCTCTTCAGCCTCGCGAGACCCTTCACCAAGTCCATG

Function

symbol description
wwox Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Acts upstream of or within cellular calcium ion homeostasis. Predicted to be located in cytoplasm and nucleus. Is expressed in cranial nerve II; gut; heart; and presumptive cardiac ventricle heart tube. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase).

GO:

id name namespace
GO:0006915 apoptotic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0006874 cellular calcium ion homeostasis biological_process
GO:0016055 Wnt signaling pathway biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0016491 oxidoreductase activity molecular_function

KEGG:

id description
ko04990 Domain-containing proteins not elsewhere classified

ZFIN:

id description
ZDB-GENE-040426-858 Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Acts upstream of or within cellular calcium ion homeostasis. Predicted to be located in cytoplasm and nucleus. Is expressed in cranial nerve II; gut; heart; and presumptive cardiac ventricle heart tube. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase).

Ensembl:

ensembl_id ENSDARG00000007614

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00048967 False 541 processed_transcript 0.52 3 36960724 36975214
TCONS_00048968 True 1430 mRNA 0.53 8 36966731 37071036

Neighbor

gene id symbol gene type direction distance location
XLOC_024885 CU929365.2 coding downstream 133233 36826484 ~ 36827491 (-)
XLOC_024883 NA coding downstream 170495 36726057 ~ 36790229 (-)
XLOC_024884 CU914144.1 coding downstream 225841 36734247 ~ 36734883 (-)
XLOC_024882 irx3b coding downstream 467945 36488164 ~ 36492779 (-)
XLOC_024881 CR354435.1 coding downstream 590432 36369921 ~ 36370292 (-)
XLOC_024887 hprt1l coding upstream 2153 37073189 ~ 37084032 (-)
XLOC_024888 nfat5a coding upstream 23440 37094476 ~ 37121335 (-)
XLOC_024889 NA coding upstream 63750 37134786 ~ 37140107 (-)
XLOC_024890 si:ch1073-174d20.2 coding upstream 71546 37142582 ~ 37160606 (-)
XLOC_024891 FP312612.1 coding upstream 73932 37144968 ~ 37145083 (-)
XLOC_024869 NA non-coding downstream 801245 36155630 ~ 36159479 (-)
XLOC_024868 NA non-coding downstream 808339 36139843 ~ 36152385 (-)
XLOC_024867 CU302251.1 non-coding downstream 902069 36058520 ~ 36058655 (-)
XLOC_024895 NA non-coding upstream 141529 37212565 ~ 37215662 (-)
XLOC_024898 NA non-coding upstream 200349 37271385 ~ 37273796 (-)
XLOC_024900 CU207301.2 non-coding upstream 223830 37294866 ~ 37322081 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000357_00424743_00512507 WWOX coding CI01000357 null 424743 ~ 512507 (-)