XLOC_026180 (pdgfab)


Basic Information

Item Value
gene id XLOC_026180
gene name pdgfab
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007114.7
NCBI id CM002887.2
chromosome length 62628489
location 12924930 ~ 12970428 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00051090
ACAGCATTCAGTGCACGAGCTCCTGACAACAAGACCAGCTCTGAGCTCTTCCCCTCCTTGCTTTATTCATGGATACTAACCTGCTAGGATTGTACTTTCACCGCATGACGAGCCACTTTTGGAAGAGCCGGTGCTGAGCTCCACATGAGGTGCATGGACTCACTTCTAAACTCTTCTGAAGTTTCCCAAAGAGTTTTATTCTTCATTAATTGGCATAGGCAATGCAAAAGGCTTTAACTATTCGGATTGTTGGACAGCCATGACGACCTTTTGCAACTTTTGAgatctttttcttcttctccagCATTTGGACCAACACCTGGAGCTCCAGCtcggattttttttttcctctttagaCTTGAGCTGGTGCATCGGGTCATTTATAGAGAGATATCTTCAAGGTATGGTTCTGGACTCTCTGAGCTCAGGAGCGGATCCAAAGCTCCTACAGTCTTCATCTTTCTTGCTGGGTGGGAAATTGACATTGGAAGGAGATGAGAACCCTATTCTGCTGCTTTCTGCTCCTCACCTCGCACCTTCTGCTGGCAGCTGCTGAGAAGGAGTTTCCCATCCCTCAGGAGTTCATCGACAGACTGTCCCACAGCGAAATCAACAGCATCAGCGACCTCCAGCGGCTACTGGAGGTAAATTCCCCAGGTCCTGGAAATGAGGTGATTGAGGAGGTCAAGCAGAAGCACCATCAGAAGAGCCAGCATTCATACAAGAGCTTCGCCTCCGATCTGAAGAGCCGACAGCTGTCCCATCGGCGGAAGAGGAGCGTTGTAGAGGAGGCGGTGCCGGCCATGTGCAAGACCCGGACGGTGATCTACGAGATCCCCCGCAGTCAAGTGGATCCCACTGCTGCAAACTTCCTCATCTGGCCTCCGTGTGTGGAGGTGAAGCGCTGCACCGGCTGCTGCAACACCGGAAACATGCGCTGCCACCCCTCCAAAAAACAGCACCGCACTGTCAAGGTGGCGAAGGTAGAGTTTGCGTCGCGTAAGAAAGCGAAATTGAAGGAGGTGCTGGTCCGGTTAGAGGATCACCTGGAATGCATATGCACGTCCCAGCATCACGTGATAGAGCACGTGGAGGCAGACACAGGCCCACGCACAGTTAAAAACCGTAAAAAACGGAAACACAGAAAGAAAGCAGTGGCCGCACTGATCAACAAGGATATTCAATAAAAGGCAAACATTTCCTAGCAGTCAGCGGACCAAAATATCCTGCAGTGGACATGAGGTGAAACCACATCAAGCGAGCGACTGAAGGACTACAGTGTCTACGTAATACTGCAGCAGCACTGGGACTTTGACCTCAGACCCCATTGctgttcgaaaaaaaaaaaagatactgtATCCAGAGGAacattatacacaaacacaacaccaaAGGTGCTTTCTACGAACTCTGTCAAACACTGAAGACAAACGGGATTGGTATTCGGTTAATTATTAAGTGGTCAAACACTGGGCGGAAACGAAACTGACAAAGACTATGTTTGTGTCGCTTCTCTGTTCTTTATGACTCTGCTAAAGGTCAAGGATGAGGAGAAAGTCTTTTGGAGAACACTACGTTTGTAGAGACCATGAACTTCACACATGCTTTGGATGGGTTTTTGGATCCAGATTGGCCTGAAGGATGGACTCAAAAAGTGGAAGAGCATATTAAAGGATGTGTTGTCATATAACCTCGCTTAAATAGAAGACGCTATTTCACGCTGCTGCTCTCTATCAAGTCCTCTTGGGTCCAGAACATTTCAGCTGCGATTTCCAATGTGCCTCTAGAAAGAAGCAAAGCGCTCTGTCCATGAACTTTCCGAAGGCAGCGCAATGCCGCCGTTATGCCAGATTAAAGTATTTATGTATGCAATATCTCTTGCTCTCTACCATCTCTGTTGCATAATCCAATGTAAGAACGGCTCATCATCTTTGTTGATCTGCAAGTATTATCAGTATCATTCTCGCTTATACTCTACAGAAGATATAGGAAATTGGTGTCATAGGAAGATGGCTGTGGAAAGatgctttatttttgttaaaatatatatatatttataatgctaATGTAGAATCAAGCAGGAAGTATGTCATGTGCCGTGTTTTCTGTTGTTGTGGTatattggttgtttggttggaaAATACGACATCAACAGGTTGGCCATCACACAAGGTCAGAAGATTCATGATTTCCTCCAAAATAACAGTTAAAGCTGAACATACAAAGAACATTCACATAAACACTTAGGTATGAAgcttttgtaataaataaacaaatcaaaacaaa
>TCONS_00051091
GTGGCGAAGGTAGAGTTTGCGTCGCGTAAGAAAGCGAAATTGAAGGAGGTGCTGGTCCGGTTAGAGGATCACCTGGAATGCATATGCACGTCCCAGCATCACGTGATAGAGCACGTGGAGGCAGACACAGTGGACATGAGGTGAAACCACATCAAGCGAGCGACTGAAGGACTACAGTGTCTACGTAATACTGCAGCAGCACTGGGACTTTGACCTCAGACCCCATTGctgttcgaaaaaaaaaaaagatactgtATCCAGAGGAacattatacacaaacacaacaccaaAGGTGCTTTCTACGAACTCTGTCAAACACTGAAGACAAACGGGATTGGTATTCGGTTAATTATTAAGTGGTCAAACACTGGGCGGAAACGAAACTGACAAAGACTATGTTTGTGTCGCTTCTCTGTTCTTTATGACTCTGCTAAAGGTCAAGGATGAGGAGAAAGTCTTTTGGAGAACACTACGTTTGTAGAGACCATGAACTTCACACATGCTTTGGATGGGTTTTTGGATCCAGATTGGCCTGAAGGATGGACTCAAAAAGTGGAAGAGCATATTAAAGGATGTGTTGTCATATAACCTCGCTTAAATAGAAGACGCTATTTCACGCTGCTGCTCTCTATCAAGTCCTCTTGGGTCCAGAACATTTCAGCTGCGATTTCCAATGTGCCTCTAGAAAGAAGCAAAGCGCTCTGTCCATGAACTTTCCGAAGGCAGCGCAATGCCGCCGTTATGCCAGATTAAAGTATTTATGTATGCAATATCTCTTGCTCTCTACCATCTCTGTTGCATAATCCAATGTAAGAACGGCTCATCATCTTTGTTGATCTGCAAGTATTATCAGTATCATTCTCGCTTATACTCTACAGAAGATATAGGAAATTGGTGTCATAGGAAGATGGCTGTGGAAAGatgctttatttttgttaaaatatatatatatttataatgctaATGTAGAATCAAGCAGGAAGTATGTCATGTGCCGTGTTTTCTGTTGTTGTGGTatattggttgtttggttggaaAATACGACATCAACAGGTTGGCCATCACACAAGGTCAGAAGATTCATGATTTCCTCCAAAATAACAGTTAAAGCTGAACATACAAAGAACATTCACATAAACACTTAGGTATGAAgcttttgtaataaataaacaaatcaaaac
>TCONS_00051092
ACTGTTGCCTATGACTGATTAGTAGTGAAAGCTGAGCTATGACCGAGCATGAAGAAACTCAAGAAACGTGGCGAAGGTAGAGTTTGCGTCGCGTAAGAAAGCGAAATTGAAGGAGGTGCTGGTCCGGTTAGAGGATCACCTGGAATGCATATGCACGTCCCAGCATCACGTGATAGAGCACGTGGAGGCAGACACAGTGGACATGAGGTGAAACCACATCAAGCGAGCGACTGAAGGACTACAGTGTCTACGTAATACTGCAGCAGCACTGGGACTTTGACCTCAGACCCCATTGctgttcgaaaaaaaaaaaagatactgtATCCAGAGGAacattatacacaaacacaacaccaaAGGTGCTTTCTACGAACTCTGTCAAACACTGAAGACAAACGGGATTGGTATTCGGTTAATTATTAAGTGGTCAAACACTGGGCGGAAACGAAACTGACAAAGACTATGTTTGTGTCGCTTCTCTGTTCTTTATGACTCTGCTAAAGGTCAAGGATGAGGAGAAAGTCTTTTGGAGAACACTACGTTTGTAGAGACCATGAACTTCACACATGCTTTGGATGG
>TCONS_00051093
CGCGCATGAGACAGCATTCAGTGCACGAGCTCCTGACAACAAGACCAGCTCTGAGCTCTTCCCCTCCTTGCTTTATTCATGGATACTAACCTGCTAGGATTGTACTTTCACCGCATGACGAGCCACTTTTGGAAGAGCCGGTGCTGAGCTCCACATGAGGTGCATGGACTCACTTCTAAACTCTTCTGAAGTTTCCCAAAGAGTTTTATTCTTCATTAATTGGCATAGGCAATGCAAAAGGCTTTAACTATTCGGATTGTTGGACAGCCATGACGACCTTTTGCAACTTTTGAgatctttttcttcttctccagCATTTGGACCAACACCTGGAGCTCCAGCtcggattttttttttcctctttagaCTTGAGCTGGTGCATCGGGTCATTTATAGAGAGATATCTTCAAGGTATGGTTCTGGACTCTCTGAGCTCAGGAGCGGATCCAAAGCTCCTACAGTCTTCATCTTTCTTGCTGGGTGGGAAATTGACATTGGAAGGAGATGAGAACCCTATTCTGCTGCTTTCTGCTCCTCACCTCGCACCTTCTGCTGGCAGCTGCTGAGAAGGAGTTTCCCATCCCTCAGGAGTTCATCGACAGACTGTCCCACAGCGAAATCAACAGCATCAGCGACCTCCAGCGGCTACTGGAGGTCCTGGAAATGAGGTGATTGAGGAGGTCAAGCAGAAGCACCATCAGAAGAGCCAGCATTCATACAAGAGCTTCGCCTCCGATCTGAAGAGCCGACAGCTGTCCCATCGGCGGAAGAGGAGCGTTGTAGAGGAGGCGGTGCCGGCCATGTGCAAGACCCGGACGGTGATCTACGAGATCCCCCGCAGTCAAGTGGATCCCACTGCTGCAAACTTCCTCATCT

Function

symbol description
pdgfab Predicted to enable platelet-derived growth factor receptor binding activity. Predicted to be involved in several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of intracellular signal transduction; and positive regulation of protein autophosphorylation. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in endoderm; mouth; pharyngeal arch; pharyngeal endoderm; and pharyngeal pouch. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A).

GO:

id name namespace
GO:0043406 positive regulation of MAP kinase activity biological_process
GO:0070374 positive regulation of ERK1 and ERK2 cascade biological_process
GO:0048008 platelet-derived growth factor receptor signaling pathway biological_process
GO:0008284 positive regulation of cell population proliferation biological_process
GO:0031954 positive regulation of protein autophosphorylation biological_process
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling biological_process
GO:0030335 positive regulation of cell migration biological_process
GO:0005615 extracellular space cellular_component
GO:0016020 membrane cellular_component
GO:0005161 platelet-derived growth factor receptor binding molecular_function
GO:0070851 growth factor receptor binding molecular_function
GO:0008083 growth factor activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-060929-124 Predicted to enable platelet-derived growth factor receptor binding activity. Predicted to be involved in several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of intracellular signal transduction; and positive regulation of protein autophosphorylation. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in endoderm; mouth; pharyngeal arch; pharyngeal endoderm; and pharyngeal pouch. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A).

Ensembl:

ensembl_id ENSDARG00000098578

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00051090 False 2286 mRNA 0.45 7 12924930 12970418
TCONS_00051091 False 1181 mRNA 0.41 2 12924933 12930217
TCONS_00051092 False 579 processed_transcript 0.45 3 12925602 12932891
TCONS_00051093 True 876 nonsense_mediated_decay 0.50 4 12945644 12970428

Neighbor

gene id symbol gene type direction distance location
XLOC_026179 ccdc137 coding downstream 21321 12893141 ~ 12903609 (-)
XLOC_026178 btbd17b coding downstream 34151 12884117 ~ 12890779 (-)
XLOC_026177 NA coding downstream 75319 12829196 ~ 12849611 (-)
XLOC_026176 coro7 coding downstream 543658 12360706 ~ 12381272 (-)
XLOC_026175 NA coding downstream 566414 12355532 ~ 12358516 (-)
XLOC_026181 prkar1b coding upstream 34229 13004657 ~ 13147310 (-)
XLOC_026182 NA coding upstream 160649 13131077 ~ 13131324 (-)
XLOC_026183 NA coding upstream 377790 13348218 ~ 13361083 (-)
XLOC_026184 NA coding upstream 437682 13408110 ~ 13410057 (-)
XLOC_026185 dhps coding upstream 453507 13423935 ~ 13437817 (-)
XLOC_026171 NA non-coding downstream 811148 12111160 ~ 12113782 (-)
XLOC_026166 NA non-coding downstream 1207081 11703909 ~ 11717849 (-)
XLOC_026164 NA non-coding downstream 1344210 11576654 ~ 11580720 (-)
XLOC_026193 NA non-coding upstream 1189109 14159537 ~ 14198357 (-)
XLOC_026194 NA non-coding upstream 1190098 14160526 ~ 14199783 (-)

Expression


Co-expression Network