Item | Value |
---|---|
gene id | XLOC_002654 |
gene name | smad2 |
gene type | coding |
species | zebrafish (Danio rerio) |
category of species | model fish |
Item | Value |
---|---|
chromosome id | NC_007121.7 |
NCBI id | CM002894.2 |
chromosome length | 45420867 |
location | 14871136 ~ 14943281 (-) |
genome version | GRCz11_2017_zebrafish_Genome |
symbol | description |
---|---|
smad2 | Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic pattern specification and intracellular signal transduction. Acts upstream of with a positive effect on nodal signaling pathway. Acts upstream of or within negative regulation of transcription by RNA polymerase II; neural plate anterior/posterior regionalization; and positive regulation of oocyte development. Located in chromatin and nucleus. Is expressed in brain; head; immature eye; and tail bud. Human ortholog(s) of this gene implicated in Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2). |
id | name | namespace |
---|---|---|
GO:0007179 | transforming growth factor beta receptor signaling pathway | biological_process |
GO:0006355 | regulation of transcription, DNA-templated | biological_process |
GO:0006357 | regulation of transcription by RNA polymerase II | biological_process |
GO:0030154 | cell differentiation | biological_process |
GO:0035556 | intracellular signal transduction | biological_process |
GO:0060395 | SMAD protein signal transduction | biological_process |
GO:0009880 | embryonic pattern specification | biological_process |
GO:0007275 | multicellular organism development | biological_process |
GO:0000122 | negative regulation of transcription by RNA polymerase II | biological_process |
GO:0030509 | BMP signaling pathway | biological_process |
GO:0009653 | anatomical structure morphogenesis | biological_process |
GO:0060282 | positive regulation of oocyte development | biological_process |
GO:0045944 | positive regulation of transcription by RNA polymerase II | biological_process |
GO:0021999 | neural plate anterior/posterior regionalization | biological_process |
GO:0071144 | heteromeric SMAD protein complex | cellular_component |
GO:0005634 | nucleus | cellular_component |
GO:0005667 | transcription regulator complex | cellular_component |
GO:0005737 | cytoplasm | cellular_component |
GO:0043565 | sequence-specific DNA binding | molecular_function |
GO:0008134 | transcription factor binding | molecular_function |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | molecular_function |
GO:0005515 | protein binding | molecular_function |
GO:0046872 | metal ion binding | molecular_function |
GO:0003677 | DNA binding | molecular_function |
GO:0003700 | DNA-binding transcription factor activity | molecular_function |
GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | molecular_function |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | molecular_function |
GO:0031625 | ubiquitin protein ligase binding | molecular_function |
GO:0070411 | I-SMAD binding | molecular_function |
id | description |
---|---|
ko04350 | TGF-beta signaling pathway |
ko04390 | Hippo signaling pathway |
ko04371 | Apelin signaling pathway |
ko04144 | Endocytosis |
ko04110 | Cell cycle |
ko04218 | Cellular senescence |
ko04550 | Signaling pathways regulating pluripotency of stem cells |
ko04659 | Th17 cell differentiation |
ko04926 | Relaxin signaling pathway |
ko05200 | Pathways in cancer |
ko05205 | Proteoglycans in cancer |
ko05210 | Colorectal cancer |
ko05212 | Pancreatic cancer |
ko05225 | Hepatocellular carcinoma |
ko05226 | Gastric cancer |
ko05166 | Human T-cell leukemia virus 1 infection |
ko05142 | Chagas disease |
ko05321 | Inflammatory bowel disease |
ko05415 | Diabetic cardiomyopathy |
ko04933 | AGE-RAGE signaling pathway in diabetic complications |
id | description |
---|---|
ZDB-GENE-990603-7 | Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic pattern specification and intracellular signal transduction. Acts upstream of with a positive effect on nodal signaling pathway. Acts upstream of or within negative regulation of transcription by RNA polymerase II; neural plate anterior/posterior regionalization; and positive regulation of oocyte development. Located in chromatin and nucleus. Is expressed in brain; head; immature eye; and tail bud. Human ortholog(s) of this gene implicated in Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2). |
ensembl_id | ENSDARG00000006389 |
RNA id | representative | length | rna type | GC content | exon number | start site | end site |
---|---|---|---|---|---|---|---|
TCONS_00004930 | False | 3895 | mRNA | 0.43 | 12 | 14871136 | 14929659 |
TCONS_00004929 | False | 3816 | mRNA | 0.43 | 11 | 14871136 | 14929659 |
TCONS_00004931 | False | 1994 | mRNA | 0.52 | 11 | 14872932 | 14929630 |
TCONS_00004932 | False | 1949 | mRNA | 0.53 | 12 | 14873105 | 14929679 |
TCONS_00004933 | False | 1416 | mRNA | 0.54 | 10 | 14873184 | 14920989 |
TCONS_00004934 | False | 812 | mRNA | 0.54 | 5 | 14894653 | 14943281 |
TCONS_00004935 | True | 555 | mRNA | 0.53 | 3 | 14920765 | 14929392 |
gene id | symbol | gene type | direction | distance | location |
---|---|---|---|---|---|
XLOC_002653 | CT027820.1 | coding | downstream | 138737 | 14732283 ~ 14732399 (-) |
XLOC_002652 | skor2 | coding | downstream | 314158 | 14547941 ~ 14556978 (-) |
XLOC_002651 | ier3ip1 | coding | downstream | 325478 | 14542726 ~ 14545658 (-) |
XLOC_002650 | hdhd2 | coding | downstream | 330693 | 14525184 ~ 14540443 (-) |
XLOC_002649 | galt | coding | downstream | 382618 | 14263684 ~ 14488518 (-) |
XLOC_002656 | NA | coding | upstream | 87725 | 15031006 ~ 15042748 (-) |
XLOC_002657 | NA | coding | upstream | 89691 | 15032972 ~ 15034960 (-) |
XLOC_002658 | cldn23a | coding | upstream | 103556 | 15046837 ~ 15048781 (-) |
XLOC_002659 | cldn23b | coding | upstream | 107188 | 15050469 ~ 15053614 (-) |
XLOC_002660 | CT027832.1 | coding | upstream | 139129 | 15082410 ~ 15086297 (-) |
XLOC_002648 | BX000705.1 | non-coding | downstream | 939440 | 13931569 ~ 13931696 (-) |
XLOC_002647 | BX293994.1 | non-coding | downstream | 1258888 | 13612133 ~ 13612248 (-) |
XLOC_002646 | BX293994.2 | non-coding | downstream | 1263993 | 13607027 ~ 13607143 (-) |
XLOC_002643 | CR759894.1 | non-coding | downstream | 1565953 | 13305065 ~ 13305183 (-) |
XLOC_002666 | NA | non-coding | upstream | 773458 | 15716739 ~ 15724104 (-) |
XLOC_002673 | NA | non-coding | upstream | 2062944 | 17006225 ~ 17010898 (-) |
species | gene id | symbol | gene type | chromosome | NCBI id | location |
---|---|---|---|---|---|---|
grasscarp (Ctenopharyngodon idella) | CI01000304_04161154_04166640 | NA | coding | CI01000304 | null | 4160216 ~ 4166640 (-) |