XLOC_027097 (optn)


Basic Information

Item Value
gene id XLOC_027097
gene name optn
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007115.7
NCBI id CM002888.2
chromosome length 78093715
location 8016457 ~ 8027318 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00053413
GTGAATGGAAGCAGCGCTACAGTAGATCCATATGAAGGTGGATAGACATAAACCTGTGTCAGGCTGACTGTAACGCACCAATCATTCTTGATATCATATATGTGCGTTTAGCGCTTTCCACTGACGTTTGGATCAGGAAGAGCAGCATTTCCCAAAACAAGTTGCTGTACACAAGACGCGATCGCCTGTTTAACAGATTCTGAAAGAAAGCATGGCATCTGGATCATCGATGATGAATGGGGACATTAGTCACCCACGTGGGTCTGGTCCAGGGAATCTGGGCAGTTTAGAGGAGACCCTCCAGCAAATGAACACGCTAATCAAAGAGAACCGAGACCTGAAAGAGGCTCTGAAACAGACCAACTTGTCCATGAAAGAGAGATTTGAGGGTCTTTCTGCTTGGAAGGAGAAGCAGAAGGAGGAAAGAGACTTCCTGGAGCAACGATTAGAGGAGGCCAGAACCAGACTGAACACTATGGACGTGGAGAACGAGGCGTTGAAAAATCAAGTGAAAGAGCTGGAAAAAAGTGGAGCTGAGtgtttgcACACTGAACTGGAGGCCCTGAGAGGTCAGATTCTTCGCATTCAAGCAGAGAAGAATGATTTAGTTGCGATGAACTCTGAACTCCAACTCAAAATGGGTCAAGGTTCACCTAGCAACTCCTTCATTGAGATTAGAATAGCTGATGATGACTTAAAAGTGACCAAAGATTTATCCAGTGTGCCAGAGGCATCGGCGTTCTCCATgcCAAAGGCTGAGTCAGAGGAACAGACGGTGAGGCAGCTGCTTCGCTCGCTCCGAGCAGAAACTGATGAGAAGGAGAGACTGCAGCTCACGCTCCAGGAGGCTCGTGGGAGAATCGCAGAGTTAGAGAGCAAACTGGAACATGCTGACAGCAGCGCACAGACATCTCTACCCTCTGCAGCTGAAACCAATGCTAGCACTGAGGTGAAGAATCTGGAAGATCAGTTGTTGAAGCTCTGTAATGAGTTGAAGCAAGCTCAGATTAAACTGGACGAGGCTGAGAGCATGAAAAGAAACCTGCAGGACAGATGTAAAGATTTGGAGCAGGATTTGGGCACTTTAAAGACTCAGCTCGGAGACAAACAGAAGGTCCAGGCTGAGAACGACTGTCTGAAGGTTCAGATGGAAAGCCTCCAAGCGGCGATCAAACTGGAACAGAAGAAAACCCAAGATGAGAAGAACAATCTAAACCAGCTGAAAGATGCGTACACCAAGCTGTTTGAAGACTACAGTGAGCTCCAGGAGGAAAAGAAGAAGAGAGAgGGTTGTGTATCAAAGGACGATTATGATGAACTCCAAACCAGGTTTGCAACTGCTGAAAAGGCACTTGCAGATAAACAGCAGAAAATCGATGAGATGAAGATGGAACTATTCCAGAAGGAAAAGGATCTGGAAACCATTTCTGTTTTCCAGGCACAGGCAGAAATCTATTCCTCAGATTTCTACGCAGAAAGAGCAGCTCGGGAGAAGATTCACGAGGAGAAAGAGCGTTTGGCCACTCAGCTGGAGTATGTGAAAAAGCAGAACAGCCAGCTTCAAGAGGAGATGGAGTCACTTGGGAGGCATTCAATGAGCGAGATGCAAAGAAGGCATGTGCCACGAGGAGCCAATCCTCAAGGGCCCACAGCTCCAAACAACCTGCCTGGAGGTAGAGgtGAATGGCAGCAGCAGAACATTCCAGATCACGCTTGTCCTAAATGTGGGGAAGTCCTACCTGACCTGGACTCCCTGCAGATCCACATCATGGATTGCATCATCTGAGCCTGTTGCCTAGTAACCTTACCAGATCCCCTCATATGTGAATGAGTGGTTTGATAGCTTTACCTTCTAGCACCCTGCAAATATACTGCTTCAATAACACCGGTCTACGAACCGTGCATCCTAATAATACTGTTATTTATCAGTCTGGAGGGTTTCAGATTAATACTATAGCTGCAATCGGTCGAGGATGAGAATGAGCACTTAATGTGTAGCTTTGACTGGTTGGATATACTCTAGCTGCATCCTGTATAATGAAAATGTGACATTAAGCTGATTCAAGACACTTGACCAATGTCAAATACTATGAGTATGAATATATAATGTTGCAGGTGGGCAATCAGTGTGACGTAATATCTGTTGTGGGTGAATTACATTATTGTTTGCGAACATATTTTTAAGATTAGCTCTAATATTTTTGAGTGAAGCAAGAGTTGTAGctaaatttataatatattttcaatgCCCTGCGATAAACAGTGAGCAACAGATTGTTTGTTGGGACTGTAAAAATGTCAACGcactttattttgtttatacgtacatacaaataattaaaataagtttataaagCTCCAGCCTGTATTATCTATCACATATGGGTTCTCTCAGTAAGGTTCTTTCGAGTTGATTTCATAACTTTGGTgcgtaataaaaaacaaatatgtgtaA
>TCONS_00053414
CTGCAGCTCACGCTCCAGGAGGCTCGTGGGAGAATCGCAGAGTTAGAGAGCAAACTGGAACATGCTGACAGCAGCGCACAGACATCTCTACCCTCTGCAGCTGAAACCAATGCTAGCACTGAGGTGAAGAATCTGGAAGATCAGTTGTTGAAGCTCTGTAATGAGTTGAAGCAAGCTCAGATTAAACTGGACGAGGCTGAGAGCATGAAAAGAAACCTGCAGGACAGATGTAAAGATTTGGAGCAGGATTTGGGCACTTTAAAGACTCAGCTCGGAGACAAACAGAAGGTCCAGGCTGAGAACGACTGTCTGAAGGTTCAGATGGAAAGCCTCCAAGCGGCGATCAAACTGGAACAGAAGAAAACCCAAGATGAGAAGAACAATCTAAACCAGCTGAAAGATGCGTACACCAAGCTGTTTGAAGACTACAGTGAGCTCCAGGAGGAAAAGAAGAAGAGAGAgGACGATTATGATGAACTCCAAACCAGGTTTGCAACTGCTGAAAAGGCACTTGCAGATAAACAGCAGAAAATCGATGAGATGAAGATGGAACTATTCCAGAAGGAAAAGGATCTGGAAACCATTTCTGTTTTCCAGGCACAGGCAGAAATCTATTCCTCAGATTTCTACGCAGAAAGAGCAGCTCGGGAGAAGATTCACGAGGAGAAAGAGCGTTTGGCCACTCAGCTGGAGTATGTGAAAAAGCAGAACAGCCAGCTTCAAGAGGAGATGGAGTCACTTGGGAGGCATTCAATGAGCGAGATGCAAAGAAGGCATGTGCCACGAGGAGCCAATCCTCAAGGGCCCACAGCTCCAAACAACCTGCCTGGAGGTAGAGgtGAATGGCAGCAGCAGAACATTCCAGATCACGCTTGTCCTAAATGTGGGGAAGTCCTACCTGACCTGGACTCCCTGCAGATCCACATCATGGATTGCATCATCTGAGCCTGTTGCCTAGTAACCTTACCAGATCCCCTCATATGTGAATGAGTGGTTTGATAGCTTTACCTTCTAGCACCCTGCAAATATACTGCTTCAATAACACCGGTCTACGAACCGTGCATCCTAATAATACTGTTATTTATCAGTCTGGAGGGTTTCAGATTAATACTATAGCTGCAATCGGTCGAGGATGAGAATGAGCACTTAATGTGTAGCTTTGACTGGTTGGATATACTCTAGCTGCATCCTGTATAATGAAAATGTGACATTAAGCTGATTCAAGACACTTGACCAATGTCAAATACTATGAGTATGAATATATAATGTTGCAGGTGGGCAATCAGTGTGACGTAATATCTGTTGTGGGTGAATTACATTATTGTTTGCGAACATATTTTTAAGATTAGCTCTAATATTTTTGAGTGAAGCAAGAGTTGTAGctaaatttataatatattttcaatgCCCTGCGATAAACAGTGAGCAACAGATTGTTTGTTGGGACTGTAAAAATGTCAACGcactttattttgtttatacgtacatacaaataattaaaataagtttataaagCTCCAGCCTGTATTATCTATCACATATGGGTTCTCTCAGTAAGGTTCTTTCGAGTTGATTTCATAACTTTGGTgcgtaataaaaaacaaatatgtgtaA

Function

symbol description
optn Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity. Acts upstream of or within axonogenesis; defense response to bacterium; and vesicle localization. Predicted to be located in autophagosome; perinuclear region of cytoplasm; and recycling endosome. Predicted to be active in Golgi apparatus and nucleus. Is expressed in several structures, including eye; otic vesicle; periocular mesenchyme; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Orthologous to human OPTN (optineurin).

GO:

id name namespace
GO:0006914 autophagy biological_process
GO:0042742 defense response to bacterium biological_process
GO:0016192 vesicle-mediated transport biological_process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling biological_process
GO:0034067 protein localization to Golgi apparatus biological_process
GO:0090161 Golgi ribbon formation biological_process
GO:0007409 axonogenesis biological_process
GO:0051648 vesicle localization biological_process
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0005768 endosome cellular_component
GO:0005776 autophagosome cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0055037 recycling endosome cellular_component
GO:0005634 nucleus cellular_component
GO:0031410 cytoplasmic vesicle cellular_component
GO:0005737 cytoplasm cellular_component
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding molecular_function
GO:0046872 metal ion binding molecular_function

KEGG:

id description
ko04137 Mitophagy - animal
ko05014 Amyotrophic lateral sclerosis
ko05022 Pathways of neurodegeneration - multiple diseases
ko04131 Membrane trafficking

ZFIN:

id description
ZDB-GENE-030131-8103 Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity. Acts upstream of or within axonogenesis; defense response to bacterium; and vesicle localization. Predicted to be located in autophagosome; perinuclear region of cytoplasm; and recycling endosome. Predicted to be active in Golgi apparatus and nucleus. Is expressed in several structures, including eye; otic vesicle; periocular mesenchyme; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Orthologous to human OPTN (optineurin).

Ensembl:

ensembl_id ENSDARG00000002663

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00053413 False 2455 mRNA 0.44 14 8016457 8027318
TCONS_00053414 True 1614 mRNA 0.43 9 8021633 8027318

Neighbor

gene id symbol gene type direction distance location
XLOC_027096 camk1da coding upstream 33441 7888047 ~ 7983016 (+)
XLOC_027095 cdc123 coding upstream 132726 7876197 ~ 7883731 (+)
XLOC_027094 ucmaa coding upstream 165968 7841627 ~ 7850489 (+)
XLOC_027093 phyh coding upstream 180044 7827261 ~ 7836413 (+)
XLOC_027092 si:ch1073-67j19.2 coding upstream 190153 7822773 ~ 7826304 (+)
XLOC_027098 NA coding downstream 18124 8045442 ~ 8049258 (+)
XLOC_027099 CU695020.2 coding downstream 107276 8134594 ~ 8134710 (+)
XLOC_027100 ninj2 coding downstream 141196 8168514 ~ 8208654 (+)
XLOC_027101 ERC1 coding downstream 185745 8213063 ~ 8515824 (+)
XLOC_027102 BX649324.3 coding downstream 476369 8503687 ~ 8503801 (+)
XLOC_027090 NA non-coding upstream 298798 7715601 ~ 7717659 (+)
XLOC_027088 NA non-coding upstream 349711 7652574 ~ 7666746 (+)
XLOC_027087 NA non-coding upstream 420760 7545660 ~ 7595697 (+)
XLOC_027085 NA non-coding upstream 509987 7415280 ~ 7506470 (+)
XLOC_027083 FO681358.1 non-coding upstream 852583 7163758 ~ 7163874 (+)
XLOC_027105 NA non-coding downstream 688807 8716125 ~ 8726451 (+)
XLOC_027107 NA non-coding downstream 847247 8874565 ~ 8885723 (+)

Expression


Co-expression Network