XLOC_027219 (smo)


Basic Information

Item Value
gene id XLOC_027219
gene name smo
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007115.7
NCBI id CM002888.2
chromosome length 78093715
location 14971239 ~ 14979937 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00053624
acttttttgttatttgtgtgtgtgtgagtgtgtgcacccCCTCCGTGTGCATACCAGGACAGGGAAAACCGATTCTTCTGAAAGACATTATGGGATCAGTGGATCCATGGTCTTCATCCGATGAGCAGATGAGTTTTGACAACAATTCTCGCTTTCTGGTTTTACTGTAAACTGGGGGGACGCGGGGACGCGCTCAAGGGGGACGGAGCGCGCAGCCCCGGGATCAAGTTACAGTCCCAGTCCCAGACTTTTCAAGGCAACATTTTTTCCTCCATCCCAAAAGTGGGGGATGGTGAACGCTATTTGGTTTGTTCTAACTTTTCCTGTAAGAAACTGGAACGGAGCAAATCTTGGCGCTGAACTTACAAAAAGAAACTTTTGTTGACAACTTTTTGCGCACCGCAATTGTACGATGAACAGATTTTCAACAGTATGTGCCCGAGAACGGAGGCATAAAAAACTTTGGAATCGGACTAAAAGGTGTTTCTTTTAATAGGAAATTTTGTTTAATCGCGATTCTATGTCGTATCCAAAATTTGTCGTGTTTTGAAAACTCAACGCGCATCGCGCACGAGTGGAGCTCGCAAGTTTATTTGGAAACATTTGATGAAACATCGCTACTTTGTTGCGTCTCCAAGATGTCCTCCAAGCGCCCCTGCTCCATTGTTGGAAGCTTTTGGATGCTTTGGATCTGGACAGCTACCTCTATGGTCGCCAGGGCGGTCATCTTGCACCCAAATGAAACTATCTTTAACGACTTTTGTAAGAAATCTACAACTTGTGAAGTGCTAAAATACAATACGTGCCTAGGCTCGCCTTTGCCGTACACGCACACGTCTCTGATTCTGGCTGAAGACTCAGAAACTCAAGAGGAAGCCTTCGAGAAATTGGCCATGTGGTCTGGGTTGAGAAATGCTCCTCGCTGTTGGGCCGTCATTCAGCCGTTGCTGTGTGCCGTTTACATGCCAAAGTGTGAGAATGGAAAGGTGGAGCTGCCCAGCCAGCACCTGTGCCAAGCTACACGCAATCCATGCAGTATTGTGGAGCGGGAGAGGGGCTGGCCCAACTTCCTAAAGTGTGAAAACAAGGAGCAGTTCCCTAAGGGTTGCCAGAATGAAGTACAGAAGCTCAAATTCAACACTTCAGGCCAATGCGAGGCTCCGTTGGTCAAAACCGACATCCAGGCAAGTTGGTATAAGGATGTGGAAGGCTGTGGGATCCAGTGCGACAACCCTCTGTTCACAGAGGACGAGCACTCAGACATGCATAGCTACATCGCCGTCTTCGGTACCATCACTCTCCTCTGTACCTTCTTCACACTGGCCACATTTCTTGCAGACTGGAAGAATTCCAACCGTTACCCCGCTGTGATCCTCTTTTACGTCAACGCCTGTTTCTTCATTGGAAGTATTGGATGGCTCGCTCAATTCATGGATGGAGCCCGCAATGAGATAGTATGCAAAAGCGACAACACTATGCGACTTGGAGAGCCATCATCCACCGAGACGCTGTCATGCGTGATTATCTTCGTCATTGTGTATTACTCGCTTATGTCTGGAGTTATTTGGTTCGTTATGCTCACTTATGCCTGGCACACATCATTCAAAGCCCTTGGCACCACCCATCAGCCTCTGTCTGGAAAAACGTCCTATTTCCACTTGGTCACGTGGTCTATTCCTTTTATACTGACCGTTGCTATACTGGCCAATTCACAGGTGGATGCAGATTCAGTTAGTGGCATTTGCTTTGTCGGCTATAGGTATTATGAATATCGTGCCGGGTTTGTTCTGGCTCCTATTGGGTTTGTCCTTGTTATTGGTGGCTATTTCTTGATACGAGGGGTTATGACATTGTTTTCCATTAAAAGCAACCATCCAGGGCTGCTCAGCGAAAAAGCTGCCAGTAAAATCAATGAAACCATGCTAAGGCTTGGCATATTTGGATTCCTGGCTTTTGGTTTTGTCCTGATTACATTCGGATGTCATTTTTATGACTTCTTCAATCAAGCTGAGTGGGAAAGAAGCTTCAGGGAATATGTTCTATGTGAAGCTAATGTCACCATAGCTCACCAGACCAACAAGCCGATCCCAGAATGTGCCATCAAGAACAGGCCCAGTCTGCTGGTGGGGAAGATCAACCTCTTCTCAATGTTTGGCACAGGCATTGCAATGAGCACCTGGGTTTGGACAAAGGCAACAATCCTCATTTGGAAACGGACCTGGTTCAGAATCATTGGACGAAGCGACGATGAGCCGAAACGCATTAAAAAGAGTAAAATGATTGCCAAGGCATTCTCAAAGCGAAAGGAACTCCAGAAAGATCCTGAGAAAGAGCTGTCCTTTAGCATGCACACAGTTTCCCATGAGGGACCTGTGGcGGGTATCAACTTTGACCTGAATGAACCGTCGATTGAGATGTCTTCTGCATGGGCCCAACATGTGACCAAGATGGTGGCAAGAAGAGGGGCAATTTTACCGCAGGATATCTCAGTGACACCCACTGGAACACCCATTCCGCCTCCAGAGGAAAGGAACAAACTTTGGATGGTCGAAGCAGAAATTTCTCCTGAAATGAtgaaaagaaagaagaagaagaaaaagcgaAGGAAGGAAGTACGGCCAGCGGGTCCTGCAGCAGATGAAGGGAATCCTGCCTACCACCGGAGGGAGTTTGGCCCCAGTGCAGTGCCGCGTCTCCCAAAACTTCCTGGTCACCGGAGTCTGGTGGCTAACCTTTGGGAACAGCAGCGACAGCAGCAGGAGGAACAGGATATGCTACCTGGAGCCTTCCCAGAATTCAGGCCTTCGTGTCCACTTCCTTACCAGGATAGGTACGGTGGGCTGGGATATTTGCGCAATAAACCCTCCAGTCTCCCTCTGGCCAATCCCCTGACGCTAAGAGATAGCATGCAAGGAGATTTAAGTCACTTCCAGCAAAGCTCATGGCAACCTAAAGGGGTTTTCCGGCACCTTGGGCAGGAGGCTTCTATGATGGATGTTGGCAGGACTGCGGTTGTGCCACGGGCAGATGGCAGGAGGGGTGTACAAATACATTCCAGAACCAATCTTATGGATGCTGAGCTATTGGATGCTGACTCAGATTTTTAAGTCTTTGGAGTTACTGGTGCTCATTCTGTGCATAAAAACAAAAGGTGCTGGATACTTACTCCAAACTATCAACTATGAGCAGAAGTGGGTTTGAACTGCTGTGCCGGCTCTGCTTGTGTAAAGGATAATATTTTTTTGCAACCCTCATGATGTTATGAATTTTGAACTGGATTtatgaaacataaaaaataaaacatttgtgttttCGATGTAGACATACCGTGCAGTTCTGCACTTTTTTATTGTGGCAACTCATTTGGTTCAGTAGCCAAGTGAGCTAAGATGACACTTTCTTGAATTTTGACCCCTTTCACTGTTTGGAAAAAAGGTTAGGGGTCATTCATTCATAATACGTCTTTGCGCCTAAAAACATGAAATACAAAAAAGCCTCTTTCGCTATgttacttttaaataaaacagtcaTAATGTTAATTTCCTATTGTAAACATAAGCTTGTAATTCTTGTCCCACCTcagagttcttctgattggtcctctGCTTTGGAGCAGACATTGATGACTGGCGCTGCTTGTAAAAGTTGAAACTCTTTTTCACTTGGCATCTGAAAAATACAGCATTCATGTGTGAAACATGAAAGACGCAAGATCAATGGGCATTTATGTCAGTTTATGGTGTTTACATACACAAACAATGGAAAAAAAGCACATGGAAATGGgtaaatcatgctgtgtgaattagggctgcacgatattggaaaaatctagcattgcGATATTCTTTTAttctgccatatatatatattgcgatatgaatagaGTTTCACTAGATgtgttgaataactatttggaaagaatttatcatttttagattgattgggatgattctgtagaggagtgcatttgcataaaatataagaaacaatctacaagcattgataaattaaataaagaaaaatatacaaattatataaacagcattttattgttattCAAGGAGTCGAACTGTATTCGGGTATACAGTAATTGACTAatcaattgtaaaataatactgcatagtcttctctttataaacaatgaaataaaatttatcataatttgtcaaaattttaaaaccctcacacaatCACAGGCCTCTTCCTTTCGAAATGATAAATTAAAATCCAGCCTGAACATTGCATAAATTTGTGATGTGGCTTTAATGCATTGCAagatcaatgctgaaacaatgtattgtgcagccctagtgtgaaTGACCCCATAAAGTCTCCTGCCGCTTTATTCCATGAATAATTCCAATCTTGGCTTTAGGGGTTCAGTTCTACAGTACTCAAAAAGAAAGAATTTCATTTCATAATAACTGTTTTCAAACAGGTTTTCCCAActatccaatagtatctggatgcagcctttatgatgcaagctgaaatcgcatcactcagcgatgcaatgtcaggcacaatgcactcaatggagagAGTGACGTCACTTtgacaggtagggttaggggtgggaatGGGATTAGGTGGGCCtaataaaaagcattggatgcagctcagattgcactgcaccaggtctgcatcaaGACCCCTCTCGATGGTTGAGCCAATATTGCAGTGTTGGCATATTCAAAATAGCCTATAACATTTAGGAGGTGCTATAACCAAATTTGTCATCTGCCCTGAAATCATGGTGGCCATGAAGTGTACCAATTGTTTTGATACATTGAAGTTACCCAGAGATACAGACTTACGTTCAATTTTGGGATGATATGATAACTTTGCGTCTTTACTAACTTTTGGACAGAGGTAAAAGTAAAAATACTGTCTTTTTAACGTCATCATTTATATGACAATGATTTACAGAAAAATCATTTTCCCTtttttgtgtgaatgtgaaagatttacattcatacataaataataatagtatgatTTTAAAGAACCTGCACTTTGAAACACGTCTTTTCACATTTGTGCTTTCAAAATGCTATTGTCATGTAAATGAATGGCCAAGATGCATAACAGGTTTTCTGCTTTTATTTGAAATCAGTTTTATCTGAGAAAATAGCATCTGATCCTCTTTAAAACAACTTTTCTTCATCTACCATTCATTATTCAAACAGACAAACCGTCCCTTCTAAAATACACGTCATTGGTTGATCCAGTGTCTCTATGTccaaataaatacattgtttacacttttttttgaGTAGCCTATGTGAATGGATTATTTCAAGTTGCCCCAACATAATAAGCTGTAATACGCAGAGCATGGTTAACTTGGAACAACTCCAGTTTTTCTTGCATTTTCTTAGAGAGTAAGTAAGGACATAgtgtctgaagaaaaaaaaatgaaaacaaaaaaggaaatcttttgtattacatttgtttgaaaacaaagaATAACATGCTATTTCTTCAGAATAGAGAGTTTATTTGTAACTATTGTTTTGGTGTTTTTTGGAAAAATTGCCTGGTGCAATCACAAACAAGTCCACATTTCTTATTCAAAGAGTAAGAGAAAATAAAGggcattgtttatgtttttaaactgtagCTCAAATTGCCAGTGGTTATGTACAATAATGTTTCCGTTGACAATTATTTCTGTACAGTGCTATTGCAAAagcaaaaactattttatattttagatgtttgttgttttattttattttttaaaactgtacatATTTTAGCTCACATTTGTTTCCTACAGCTTTCACTATGACTTTTGCTTCACACAGATATGTATTTGTTTCCTggtgtgcattttgtttcatattttacacttttttaaatatttcattgtgATGTTGCCTAGATAATTGTTAATATAAGTGAAAACATTAACAATAAAGCAGCTGTGCAGCATTTTTACGACAATTTGAAGCTGTTCTTCaagaatgtattattttaaaaagtttttaatgaaGATGTTTGTGCTCTGTAATTGGTTTTATATACGTTTCTCCCTATCACTGTTGCTGTTATTCCTTCACAAGAGCCACTCTATCAACATATGTTATGTCAGTATTTTCATGTGTTTGTGTGATCTTTGCTGTTCCTCCTAGCTGGAGTTTCattctaatgtatatattttaatattgacacaccattaatgaataaaaagtttaaataaaatctaa

Function

symbol description
smo Enables oxysterol binding activity. Acts upstream of or within several processes, including animal organ development; blood vessel development; and nervous system development. Located in cilium. Is expressed in several structures, including brain; mesoderm; pectoral fin bud; tail bud; and trunk. Human ortholog(s) of this gene implicated in basal cell carcinoma and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor).

GO:

id name namespace
GO:0021522 spinal cord motor neuron differentiation biological_process
GO:0021782 glial cell development biological_process
GO:0021523 somatic motor neuron differentiation biological_process
GO:0042693 muscle cell fate commitment biological_process
GO:0048741 skeletal muscle fiber development biological_process
GO:0021536 diencephalon development biological_process
GO:0021537 telencephalon development biological_process
GO:0021798 forebrain dorsal/ventral pattern formation biological_process
GO:0048745 smooth muscle tissue development biological_process
GO:0048752 semicircular canal morphogenesis biological_process
GO:0007224 smoothened signaling pathway biological_process
GO:0060896 neural plate pattern specification biological_process
GO:0007517 muscle organ development biological_process
GO:0035270 endocrine system development biological_process
GO:0048794 swim bladder development biological_process
GO:0031290 retinal ganglion cell axon guidance biological_process
GO:0048795 swim bladder morphogenesis biological_process
GO:0055002 striated muscle cell development biological_process
GO:0021587 cerebellum morphogenesis biological_process
GO:0031016 pancreas development biological_process
GO:0031017 exocrine pancreas development biological_process
GO:0031018 endocrine pancreas development biological_process
GO:0009880 embryonic pattern specification biological_process
GO:0030182 neuron differentiation biological_process
GO:0042472 inner ear morphogenesis biological_process
GO:0007275 multicellular organism development biological_process
GO:0051216 cartilage development biological_process
GO:0048557 embryonic digestive tract morphogenesis biological_process
GO:0060956 endocardial cell differentiation biological_process
GO:0072175 epithelial tube formation biological_process
GO:0048839 inner ear development biological_process
GO:0001839 neural plate morphogenesis biological_process
GO:0030239 myofibril assembly biological_process
GO:0031076 embryonic camera-type eye development biological_process
GO:0014003 oligodendrocyte development biological_process
GO:0001570 vasculogenesis biological_process
GO:0071679 commissural neuron axon guidance biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0045880 positive regulation of smoothened signaling pathway biological_process
GO:0003231 cardiac ventricle development biological_process
GO:0035912 dorsal aorta morphogenesis biological_process
GO:0014033 neural crest cell differentiation biological_process
GO:0032474 otolith morphogenesis biological_process
GO:0035143 caudal fin morphogenesis biological_process
GO:0048663 neuron fate commitment biological_process
GO:0061053 somite development biological_process
GO:0010002 cardioblast differentiation biological_process
GO:0007399 nervous system development biological_process
GO:0021984 adenohypophysis development biological_process
GO:0021986 habenula development biological_process
GO:0007411 axon guidance biological_process
GO:0007417 central nervous system development biological_process
GO:0030900 forebrain development biological_process
GO:0030902 hindbrain development biological_process
GO:0060041 retina development in camera-type eye biological_process
GO:0048702 embryonic neurocranium morphogenesis biological_process
GO:0048703 embryonic viscerocranium morphogenesis biological_process
GO:0001947 heart looping biological_process
GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway biological_process
GO:0021508 floor plate formation biological_process
GO:0007166 cell surface receptor signaling pathway biological_process
GO:0035479 angioblast cell migration from lateral mesoderm to midline biological_process
GO:0060844 arterial endothelial cell fate commitment biological_process
GO:0021520 spinal cord motor neuron cell fate specification biological_process
GO:0030425 dendrite cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005929 cilium cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0008142 oxysterol binding molecular_function
GO:0005113 patched binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0004888 transmembrane signaling receptor activity molecular_function

KEGG:

id description
ko04340 Hedgehog signaling pathway
ko04341 Hedgehog signaling pathway - fly
ko04360 Axon guidance
ko05200 Pathways in cancer
ko05205 Proteoglycans in cancer
ko05217 Basal cell carcinoma
ko04030 G protein-coupled receptors

ZFIN:

id description
ZDB-GENE-980526-89 Enables oxysterol binding activity. Acts upstream of or within several processes, including animal organ development; blood vessel development; and nervous system development. Located in cilium. Is expressed in several structures, including brain; mesoderm; pectoral fin bud; tail bud; and trunk. Human ortholog(s) of this gene implicated in basal cell carcinoma and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor).

Ensembl:

ensembl_id ENSDARG00000002952

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00053624 True 6212 mRNA 0.41 12 14971239 14979937

Neighbor

gene id symbol gene type direction distance location
XLOC_027218 tspan33a coding upstream 2598 14957360 ~ 14968641 (+)
XLOC_027217 psmc2 coding upstream 38880 14926948 ~ 14932359 (+)
XLOC_027216 akr1b1.1 coding upstream 60853 14899720 ~ 14910386 (+)
XLOC_027215 shisal1a coding upstream 107729 14826299 ~ 14863510 (+)
XLOC_027214 NA coding upstream 200654 14767982 ~ 14770585 (+)
XLOC_027220 cax1 coding downstream 1917 14981854 ~ 14990926 (+)
XLOC_027221 zc3hc1 coding downstream 26280 15006217 ~ 15010891 (+)
XLOC_027222 ube2h coding downstream 31404 15011341 ~ 15059876 (+)
XLOC_027223 NA coding downstream 91537 15071474 ~ 15076052 (+)
XLOC_027224 NA coding downstream 124757 15104694 ~ 15114467 (+)
XLOC_027213 BX571719.4 non-coding upstream 238116 14732983 ~ 14733123 (+)
XLOC_027211 BX571719.2 non-coding upstream 246025 14725074 ~ 14725214 (+)
XLOC_027208 BX571705.1 non-coding upstream 562941 14399472 ~ 14408298 (+)
XLOC_027205 NA non-coding upstream 782510 14185166 ~ 14188729 (+)
XLOC_027225 NA non-coding downstream 203568 15183505 ~ 15240713 (+)
XLOC_027228 NA non-coding downstream 889275 15869212 ~ 15881144 (+)
XLOC_027235 CR749763.5 non-coding downstream 1021301 16001238 ~ 16004425 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000020_03362565_03367403 SMO coding CI01000020 null 3362376 ~ 3367559 (-)