tp53 (tp53)


Basic Information

Item Value
gene id tp53
gene name tp53
gene type coding
species rainbow trout (Oncorhynchus mykiss)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_048574.1
NCBI id CM023228.2
chromosome length 87811138
location 50387948 ~ 50399688 (-)
genome version USDA_OmykA_1.1_2020_rainbow_trout_Genome

Sequence

>NM_001124692.1
ATTCCCCAACGCGTGGAAGAAAAGTCTAAACATATTGTGCTGGCAAATTTAACACCCCCGGCAATAACAAATGTGAATTTTCATACCGAGTTAGCTAGCAACACTTCACCGGCAACACTGCAATCAGGAGTGTCGGGGTAATCAGATCGGAGAAGCCCCGATTGGCTTTTCTTCCCTGCGTGCTGCTTTGAGGTACTAGAGAACAACATCATGGCTGATCTGGCGGAGAACGTGTCTCTTCCCCTCAGCCAGGAGTCTTTCGAGGACCTGTGGAAAATGAATTTGAACCTGGTGGCAGTTCAACCACCTGAAACCGAGTCTTGGGTGGGATACGATAATTTCATGATGGAGGCCCCCCTCCAGGTGGAATTTGATCCGAGTCTGTTTGAGGTGTCTGCAACGGAGCCTGCACCCCAGCCCTCCATTTCTACCCTGGACACTGGCTCGCCACCTACCTCCACCGTACCAACCACCTCTGACTACCCCGGGGCCCTGGGGTTCCAGCTACGTTTCCTCCAGTCCAGCACAGCCAAGTCCGTCACTTGCACAtacTCGCCAGACCTGAACAAGTTGTTCTGCCAGTTGGCGAAGACTTGTCCAGTTCAGATCGTGGTggaccaccctcctcctcctggggCAGTGGTACGAGCCCTGGCCATCTATAAGAAGCTGAGTGACGTGGCTGACGTGGTGAGACGCTGCCCTCACCACCAGAGCACCAGCGAGAACAATGAAGGTCCTGCCCCGCGAGGTCACCTTGTCAGAGTTGAGGGGAACCAGCGATCAGAGTATATGGAGGATGGTAACACTCTGAGACACAGCGTGCTCGTCCCCTATGAGCCTCCTCAGGTGGGATCAGAGTGTACCACTGTGCTCTACAACTTCATGTGCAACAGCTCCTGTATGGGAGGGATGAACCGCAGACCCATCCTCACCATCATCACCCTGGAGACACAAGAGGGGCAGCTCCTGGGTCGGCGCTCCTTtgaggtgcgtgtgtgtgcctgtcctggtcgagacaggaagacagaggagatCAACCTGAAGAAGCAGCAGGAGACAACCCTGGAGACCAAGACCAAGCCTGCCCAGGGAATCAAACGTGCTATGAAGGAGGCCTCCCTGCCTGCCCCTCAGCCTGGGGCCAGTAAGAAGACCAAGTCCTCCCCTGCTGTGAGTGACGATGAGATCTACACTCTTCAGATTCGAGGGAAGGAAAAATATGAGATGCTGAAGAAGTTCAATGACAGTCTTGAACTGAGTGAGTTGGTGCCTGTTGCCGACGCTGACAAATACCGTCAGAAACGCCTCACCAAGAGAGTTGCCAAACGGGACTTCGGAGTGGGGCCAAAGAAAGGGAAGAAACTACTGGTGAAGGAGGAGAAGAGCGACTCTGACTGAGAAGGAGAGCGagtcgttccatgtcatttcagcaagccatgacacccaccatctgaTTGTTCTGACATTGTTTCTATAATTAGAAACAGGTAAGATTGGCATTCCTAAAACATTTTGTTGATATGTACATTTTATCTTGGAGAAATTAAGCTTATTGATTGCACCCAAGCTGGCCATTTTTTAATTGATAGGATTCAGATAATATTTAAGAAATATAGTACCCAACATCTGATTTGGCTAAAACTTCTTCCTaccaatgagtaagacatgatgaatcccaaaataaatgtcaAACACCCACCCCCAACATCCAGTATACAGTTTCAGTTCtgtttgacaagtagtatggagctcTATATTGTGTTATCTGAATCCTATTAAAattgccaatttgggtgcaatcaattaacTTAATTTCTCAGATTAAATTATTTCAACaaaatgtttcaggaatgctaatcATATCTGTTACCAACTACAGAATTGATTttagaacaatctgagatggtgagTGTTAATtctctttcttgtgctttttgaggtggaacaaccagagagagagagaattaaccCGTTATGCTTAGTTTCTGTTCTGCCAAGTAAACCTTCCTTTCAATTGATTGAGGGAATGCAAGTACGGTAAACTGTTGATGCTTGCAGCTTACTAGCCTTATGTTAGCAAGCTGTTGTAGGTCTCTTAAGTGCAGGTGGAGTTTGTAAGACACAGCAGAAATATAGTAAAAAGAAAAGTGTTAATTACAGCCTTAGGTGGGTATTTAAGGTCCAATTATTGATTATTTTTTGTAATTTTGTACCCTTTAAAATGTTTGTTAAGAGGAAGAGTATACACACCAGAATTTCTACCAAACAAACACTTTATTACACTGCAACAGAAATACATGGactttttcataaaattataaaaataaaaataaacttttc

Function

symbol description
tp53 Enables DNA-binding transcription factor activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; intracellular signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in chromatin. Is expressed in several structures, including digestive system; head; musculature system; nervous system; and reproductive system. Used to study Li-Fraumeni syndrome; aggressive NK-cell leukemia; angiosarcoma; and cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53).

NR:

description
cellular tumor antigen p53 isoform X1

GO:

id name namespace
GO:0010332 response to gamma radiation biological_process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process biological_process
GO:0045786 negative regulation of cell cycle biological_process
GO:0045787 positive regulation of cell cycle biological_process
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator biological_process
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator biological_process
GO:0031571 mitotic G1 DNA damage checkpoint biological_process
GO:0007283 spermatogenesis biological_process
GO:0000122 negative regulation of transcription by RNA polymerase II biological_process
GO:0010165 response to X-ray biological_process
GO:0051782 negative regulation of cell division biological_process
GO:0016525 negative regulation of angiogenesis biological_process
GO:0031065 positive regulation of histone deacetylation biological_process
GO:0051262 protein tetramerization biological_process
GO:0060729 intestinal epithelial structure maintenance biological_process
GO:0060216 definitive hemopoiesis biological_process
GO:0045893 positive regulation of transcription, DNA-templated biological_process
GO:0071456 cellular response to hypoxia biological_process
GO:0051597 response to methylmercury biological_process
GO:0034644 cellular response to UV biological_process
GO:0043525 positive regulation of neuron apoptotic process biological_process
GO:0000785 chromatin cellular_component
GO:0005829 cytosol cellular_component
GO:0005634 nucleus cellular_component
GO:0005657 replication fork cellular_component
GO:0005667 transcription regulator complex cellular_component
GO:0005739 mitochondrion cellular_component
GO:0043565 sequence-specific DNA binding molecular_function
GO:0002039 p53 binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003684 damaged DNA binding molecular_function
GO:0003690 double-stranded DNA binding molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function

KEGG:

id description
K04451 TP53, P53; tumor protein p53

RNA

RNA id representative length rna type GC content exon number start site end site
NM_001124692.1 True 2343 mRNA 0.46 11 50387948 50399688

Neighbor

gene id symbol gene type direction distance location
slc25a35 slc25a35 coding downstream 34662 50341116 ~ 50353286 (-)
LOC118936704 NA coding downstream 37953 50346522 ~ 50349995 (-)
grk1b NA coding downstream 61914 50319070 ~ 50326034 (-)
LOC110534213 LOC106602908 coding downstream 127513 50246298 ~ 50260435 (-)
LOC110533140 LOC106563775 coding downstream 339016 50045056 ~ 50048932 (-)
LOC110534217 LOC106602903 coding upstream 1098 50400786 ~ 50442079 (-)
LOC110534218 LOC106602900 coding upstream 52765 50452453 ~ 50454285 (-)
LOC110534220 LOC106602898 coding upstream 64262 50463950 ~ 50482534 (-)
slc25a15b slc25a15 coding upstream 226442 50626130 ~ 50637048 (-)
LOC110534228 NA coding upstream 322002 50721690 ~ 50767820 (-)
G899533 NA non-coding downstream 23131 50364563 ~ 50364817 (-)
G899527 NA non-coding downstream 31147 50356340 ~ 50356801 (-)
G899524 NA non-coding downstream 36640 50331401 ~ 50351308 (-)
G899518 NA non-coding downstream 64861 50322836 ~ 50323087 (-)
G899616 NA non-coding upstream 105952 50505640 ~ 50505849 (-)
G899620 NA non-coding upstream 109410 50509098 ~ 50509346 (-)
G899626 NA non-coding upstream 121879 50521567 ~ 50611065 (-)
G899636 NA non-coding upstream 154026 50553714 ~ 50618858 (-)
G899421 NA other downstream 205160 50182396 ~ 50182788 (-)
G899409 NA other downstream 231046 50156192 ~ 50156902 (-)
LOC110534172 LOC106602940 other downstream 1503873 48881449 ~ 48907973 (-)
G896841 NA other downstream 2398872 47987761 ~ 47989076 (-)
LOC110534118 LOC106603020 other downstream 3154902 47203241 ~ 47234608 (-)
G899727 NA other upstream 321298 50720986 ~ 50721603 (-)
G899739 LOC106602890 other upstream 343470 50743158 ~ 50750233 (-)
G900070 NA other upstream 571075 50970763 ~ 50981750 (-)
G900807 NA other upstream 1055812 51455500 ~ 51455942 (-)

Expression


Co-expression Network