XLOC_028523 (pnpla3)


Basic Information

Item Value
gene id XLOC_028523
gene name pnpla3
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007115.7
NCBI id CM002888.2
chromosome length 78093715
location 8780179 ~ 8795250 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00055334
CTCTGAACAACATCAACAACCGCTCCTTTCTGCACCGAGGCGAGCAAAACGGCTTTAAAAGACATGATAGTCTGAGATTTAGCCGCAGTCATGTTTGATTTGAAAGAAGGCTGGAATCTGTCGTTCGCCGGATGCGGGTTTTTGGGGATTTATCACATCGGTGTGGCGAGCTGTTTGCTGGAGCAGGCGCCCTATCTGATCCGCGGGGCCACGAAGATCTACGGAGCCTCGGCAGGGGCTCTTACTGCCTCCGTGCTCACTACAGAGGCTTGCATAGAGAAATGTTGTGAAGACGTCATCAATGTTGCCAAGGAGGCACGCAagcgtaatctGGGCCCTTTGCACCCAACATTCAACATAGTCAAGGTGATACGTGGAGGCCTGTATCGCGACCTGCCGTCCAATGCACACACACTCTCCTCTGGACGACTCTGTGTTTCGCTCACACGCGTCATGGATGGCCAAAACGTCCTGGTGTCTGACTTCAGCTCCAAAGAGGAGCTCATCCAGGCTCTCATCTGTAGCTGTTTCATTCCTGTGTATTGCGGTTTAATCCCTCCTGCCTTCCGTGGTGTGCGTTATGTGGACGGCGGCATCAGTGATAATCTGCCCCAGTCAGAGCTGAAGAACACCATCACTGTTTCTCCATTCTCTGGAGAGAGCGACATCTGTCCAAAAGACAATTCCACCAGCTTCCACGAACTGCGTTTCACAAACACCAGCATTCAATTCAATCTGGACAACGCGTACAGACTGAGCAAGGCCCTGTTTCCCCCAGAGCCTAAAGTGCTGGCAGAGATGTGTCAGAGCGGGTATAAAGACGCCCTACGGTTTCTCCAGGAAAACAATTTGCTACAGGCAGCATGTCCAGGAGTAGACATGGCTCTGATTCAGGCCACACCAACCTGCTGCTGCCCTGGGAAGAAGAATCCAGTGGTGGAGGAAACGACCAAGGAGTGGGTCTTGCGGAGGCTCCGGCTCTTGAGGAAACACCACTGGTGGCTGGATGAACAGATTGTTGATAACCTGCCAACACCTATTAAGAAAGttttttgcGACGCCTGCAGAGAAAAGCACGGTCTGCTGGCACAGGTGACTGGTTTGCTGCCAGTGCGTGTGGCGTCTTATATGCTGTTGCCGTACACACTGCCAGTGGAATCCGCTTATTCTGCAGCTCAGAGGTTTTGGGAGTGGATCCCAGAAGTCCCTGCGGATGTGCGCTGGCTTACTGAGGTGGCAGGAGGTGTTTACAGATTGGCTTGGAAAGGTGCAGCATCAGAAGCAAACAGCGGCGCCCCCTTGAGAAGATGTGTTAGTGAACCACCAATGGCGGATTTACAGATGCCCATCAAGGACTGCACTGGACACATACCTCATTCTGCAAGCACCCTTGATAGTTACAAGTGGACTTTTCCTAACAACATCCATACAACTTCCTCTATCGACTGTCCAGAAAGTCCTGTCAGTGAGTCCAGGCAGATGAGTTTCTTTGTTGGCTCACCAAATAATTAAGAGAAGCAAATGGACCAATGCTGGGGCTTAgtaaatatacatgtatacatgACTGCCCTGGTTATATACAAGTCATTCTGCATATTTTGGCAGTGGGAAAGACAGTTTGTGTAGACAAAATCTTTGGAATCCAGCGCCGAGTGTAAATATACATGACATGTCAAGCACTCCTATTGTGACATTTTGGACGTTCTCCAAATGTGCCTTTCGTCTTTATTCAGAACCAAAGATGTGTTGATCTGTTGTATCAGCCTATGTACTGTGGACAGTTTATGCCAGAGTTTACATTGCAAGTGGTGCTAATACTTCTCTGCGACCTCAGAATACTTTAATATGTGCCATACAAGTCCATGCCACCAATAAAGAGATTAAGACAATG

Function

symbol description
pnpla3 Predicted to enable triglyceride lipase activity. Acts upstream of or within liver development. Predicted to be active in cytoplasm; lipid droplet; and membrane. Human ortholog(s) of this gene implicated in coronary artery disease; fatty liver disease (multiple); liver disease (multiple); and type 2 diabetes mellitus. Orthologous to human PNPLA3 (patatin like phospholipase domain containing 3).

GO:

id name namespace
GO:0010898 positive regulation of triglyceride catabolic process biological_process
GO:0006629 lipid metabolic process biological_process
GO:0055088 lipid homeostasis biological_process
GO:0001889 liver development biological_process
GO:0019433 triglyceride catabolic process biological_process
GO:0016042 lipid catabolic process biological_process
GO:0005811 lipid droplet cellular_component
GO:0016020 membrane cellular_component
GO:0005737 cytoplasm cellular_component
GO:0004806 triglyceride lipase activity molecular_function
GO:0016787 hydrolase activity molecular_function

KEGG:

id description
ko00561 Glycerolipid metabolism

ZFIN:

id description
ZDB-GENE-040718-27 Predicted to enable triglyceride lipase activity. Acts upstream of or within liver development. Predicted to be active in cytoplasm; lipid droplet; and membrane. Human ortholog(s) of this gene implicated in coronary artery disease; fatty liver disease (multiple); liver disease (multiple); and type 2 diabetes mellitus. Orthologous to human PNPLA3 (patatin like phospholipase domain containing 3).

Ensembl:

ensembl_id ENSDARG00000102020

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00055334 True 1891 mRNA 0.49 10 8780179 8795250

Neighbor

gene id symbol gene type direction distance location
XLOC_028522 ttll12 coding downstream 990 8739093 ~ 8779189 (-)
XLOC_028521 BX842699.1 coding downstream 44588 8709082 ~ 8735591 (-)
XLOC_028520 BX649324.2 coding downstream 141550 8634704 ~ 8638629 (-)
XLOC_028519 fbxl14b coding downstream 168338 8609517 ~ 8611841 (-)
XLOC_028518 BX649324.1 coding downstream 192271 8587787 ~ 8587908 (-)
XLOC_028524 mpped1 coding upstream 54566 8849816 ~ 8903240 (-)
XLOC_028525 NA coding upstream 109041 8904291 ~ 8905453 (-)
XLOC_028526 scube1 coding upstream 111643 8906893 ~ 9008851 (-)
XLOC_028527 NA coding upstream 253056 9048306 ~ 9050945 (-)
XLOC_028528 si:dkey-48p11.3 coding upstream 256338 9051588 ~ 9054947 (-)
XLOC_028517 NA non-coding downstream 560188 8219461 ~ 8219991 (-)
XLOC_028516 NA non-coding downstream 565744 8213170 ~ 8214435 (-)
XLOC_028533 NA non-coding upstream 593568 9388818 ~ 9389648 (-)
XLOC_028534 NA non-coding upstream 719298 9514548 ~ 9521942 (-)
XLOC_028540 BX901962.1 non-coding upstream 854033 9649283 ~ 9651968 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000066_00730057_00737661 PNPLA3 coding CI01000066 null 729715 ~ 737661 (-)