XLOC_028587 (braf)


Basic Information

Item Value
gene id XLOC_028587
gene name braf
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007115.7
NCBI id CM002888.2
chromosome length 78093715
location 12074776 ~ 12102036 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00055448
GTTTCTCGTGGTTTAAAATGGCGGCGTTGAGCAGCGCCGAGTCCCCACCGCCCGTCTTCAACGGAGACACCATGAACCGCGATCCGGAGCGGGACCCGGGACTGGACGAGCTGGGCGCGGGGCTCGAACCCGCCTGTCCCGGAGAAGCGGCGATCCCCGAATGTCAACAGGGCATTCCCGAGGAGATATGGAATATTAAACAgatgattaagttaactcaagAGCACCTAGAAGCCCTTTTAGATAAGTTTGGAGGAGAACACAATCCACCGTCTATATATCTAGAGGCCTATGAGGAGTACACTAGTAAGCTGGATGCATTACAGCAGCGGGAGCAGCAGCTTTTGGAAGCTATTGGGAATGGGACCGAGTTCTGCTCCTCGCCGACACCCACCCTGCTGGACGTGAAGGGACAGGGCATTCAGAGTGCCCCCACTGCCCCAAACACCCTAGCTGTCCTGCAGACGCCCACTGACGCAACACGAGGCAATCCCCGCTCGCCCCAGAAACCCATCGTCAGGGTCTTCCTGCCCAACAAACAGAGGACTGTGgttcCAGCTCGTTGTGGGATGACGGTCAGAGACTCCTTAAAGAAGGCTCTGATGATGCGAGGCTTGATCCCAGAATGCTGTGCAGTCTATAGAGTTCAGGATGGGGAGAAGAAGCCCATTGGCTGGGACACAGACATTTCCTGGTTGACGGGGGAGGAGCTTCACGTTGAAGTTTTAGAAAATGTGCCACTGACGACCCATAATTTTGTGCGAAAGACCTTCTTCACGCTGGCCTTCTGTGATTTTTGCCGGAAGCTGTTGTTTCAAGGCTTCCGCTGTCAGACGTGTGGCTATAAGTTTCACCAGCGCTGCAGCACGGAGGTCCCACTCATGTGTGTCAACTACGATCAGCTGGAtTTATTGCTGGCATCAAAATTTCTGGTGCACCACCCCATCACCCAGGAGGAGGTGTCATCAGAGGGCACGACACCCATTTCAGAGATGTGCCCCTCGCTACCACCATCCGAATCTACTGGCTCTCTGTGCCATCCTACTGTGTCCCCGTCCAAATCCATCCCTATCCCGCAATCTTTTAGACCTGGAGAAGAGGACCACCGTAACCAGTTTGGTCAGAGGGATCGCTCCTCATCAGCCCCTAACGTCCATATCAACACCATTGAGCCGGTCAACATTGATGATTTGATTCGTGATCAAGGCTTACCGAGGTCAGATGGAGCCCCCTCGCAACACCCAGCCCGCTGCTTGAGGAAGAACCGAACACGGACCTCAAGCCCCCTTCTGTCCTCCCACCCCAATGACATTGTCTTTGATTTTGAGCCTGAGCCAGTGTTCAGAGGCTCAACAACAGGCCTGTCCGCCACTCCCCCTGCCTCCCTGCCAGGTTCCCTGCCCAATGTGAAGGTGTCCAAATCTCCGTGCCAACCGAGGGAGAGGAAGCCATCGTCTTCATCTGAGGACCgcaataaaatgAAAACTCTGGGTCGACGGGACTCGAGCGATGATTGGGAGATTCCAGAAGGGCAGATTACTCTGGGCCAGCGGATAGGATCTGGTTCTTTTGGGACAGTTTACAAGGGGAAATGGCACGgtgacGTGGCGGTAAAGATGTTGAATGTTACAGCTCCCACTCCACAGCAGCTACAAGCCTTTAAGAATGAAGTGGGTGTCCTCAGGAAAACCCGTCATGTGAATATCCTGCTGTTCATGGGCTACACCACCAAACCCCAGCTGGCTATTGTTACTCAGTGGTGCGAAGGCTCGAGTCTCTACCACCACCTGCACATCATCGAGACCAAGTTCGAGATGATCAAGCTGATCGACATTGCCCGACAGACAGCTCAGGGCATGGACTATCTGCACGCAAAGTCCATCATCCATAGAGATCTGAAGAGTAACAACATCTTTTTGCACGAGGATTTAACGGTAAAGATTGGAGATTTCGGTCTGGCTACAGTGAAGTCCCGCTGGAGCGGATCACACCAGTTTGAGCAACTTTCAGGCTCTATCTTGTGGATGgcTCCAGAAGTGATCAGACTGCAGGATAAAAACCCATATAGTTTCCAGTCGGACGTCTACGCATTCGGCATAGTGCTTTATGAGCTTATGTCAGGGGCTTTGCCTTATTCAAACATCAACAACAGAGACCAGATTATCTTCATGGTTGGCCGGGGTTACTTGTCTCCTGACTTGAGCAAGGTGCGCAGCAATTGTCCTAAGGCCATGAAGAGACTTATGGCAGATTGTCTAAAGAAAAAGCGAGAAGAAAGACCTCTTTTCCCTCAGATCTTGGCCTCCATCGAGTTATTGGCACGCTCTCTGCCCAAAATCCACCGCAGCGCCTCTGAACCGTCTCTGAACCGCGCTGGCTTCCAGACGGAGGACTTCAGCCTATACACCTGCGCTTCCCCCAAAACACCCATTCAGGCCGGTGGCTATGGTGAATTCACAGCGTTTAAATAGTGCTGCAAATCCTAAACCTCCATCCCTTGTCAGTTTTTCAGACGTCTTGTGTTCCTATGATGGGTTCATCCATAACAACACAGAAAAAGGACAAGTTTTCAAAGAATGTGCTGTTTTTCTTCCTCTTTACCCGAAGAGCTACGGCCTCAACGgaattgctttaaaataaaaacatctctGCAGGGTGtcactttacaaaaaaataaatgtcataaaCATCGCCGGACAACTCTAATACAGCTTACAAtggagaagaaaaaataaaagactGATCCTGGTCACTGGAAAAGAAACAAACCCAAATAGATCAAATGGCAGggattaaataaaagaaagatgAATGAGTTTGGGATGAATGGAACACAAGCCCCGCCTTTGCTCCACCCCTGGAGGGGAAGAACATACAGCACTGGCCAATCAGAAAACAGGGTCCGAATTTGGACCAGTGGCGTGGAAAAAAGAGAAGATGTCAAGTCGCTGTCGAGGAAAGTTGCTGGAGGTCAGAAAATAACTTG
>TCONS_00055449
TTTTCCACTCAGTTTCTCGTGGTTTAAAATGGCGGCGTTGAGCAGCGCCGAGTCCCCACCGCCCGTCTTCAACGGAGACACCATGAACCGCGATCCGGAGCGGGACCCGGGACTGGACGAGCTGGGCGCGGGGCTCGAACCCGCCTGTCCCGGAGAAGCGGCGATCCCCGAATGTCAACAGGGCATTCCCGAGGAGATATGGAATATTAAACAgatgattaagttaactcaagAGCACCTAGAAGCCCTTTTAGATAAGTTTGGAGGAGAACACAATCCACCGTCTATATATCTAGAGGCCTATGAGGAGTACACTAGTAAGCTGGATGCATTACAGCAGCGGGAGCAGCAGCTTTTGGAAGCTATTGGGAATGGGACCGAGTTCTGCTCCTCGCCGACACCCACCCTGCTGGACGTGAAGGGACAGGGCATTCAGAGTGCCCCCACTGCCCCAAACACCCTAGCTGTCCTGCAGACGCCCACTGACGCAACACGAGGCAATCCCCGCTCGCCCCAGAAACCCATCGTCAGGGTCTTCCTGCCCAACAAACAGAGGACTGTGgttcCAGCTCGTTGTGGGATGACGGTCAGAGACTCCTTAAAGAAGGCTCTGATGATGCGAGGCTTGATCCCAGAATGCTGTGCAGTCTATAGAGTTCAGGATGGGGAGAAGAAGCCCATTGGCTGGGACACAGACATTTCCTGGTTGACGGGGGAGGAGCTTCACGTTGAAGTTTTAGAAAATGTGCCACTGACGACCCATAATTTTGTGCGAAAGACCTTCTTCACGCTGGCCTTCTGTGATTTTTGCCGGAAGCTGTTGTTTCAAGGCTTCCGCTGTCAGACGTGTGGCTATAAGTTTCACCAGCGCTGCAGCACGGAGGTCCCACTCATGTGTGTCAACTACGATCAGCTGGAtTTATTGCTGGCATCAAAATTTCTGGTGCACCACCCCATCACCCAGGAGGAGGTGTCATCAGAGGGCACGACACCCATTTCAGAGATGTGCCCCTCGCTACCACCATCCGAATCTACTGGCTCTCTGTGCCATCCTACTGTGTCCCCGTCCAAATCCATCCCTATCCCGCAATCTTTTAGACCTGGAGAAGAGGACCACCGTAACCAGTTTGGTCAGAGGGATCGCTCCTCATCAGCCCCTAACGTCCATATCAACACCATTGAGCCGGTCAACATTGATGATTTGATTCGTGATCAAGGCTTACCGAGGTCAGATGGAGGCTCAACAACAGGCCTGTCCGCCACTCCCCCTGCCTCCCTGCCAGGTTCCCTGCCCAATGTGAAGGTGTCCAAATCTCCGTGCCAACCGAGGGAGAGGAAGCCATCGTCTTCATCTGAGGACCgcaataaaatgAAAACTCTGGGTCGACGGGACTCGAGCGATGATTGGGAGATTCCAGAAGGGCAGATTACTCTGGGCCAGCGGATAGGATCTGGTTCTTTTGGGACAGTTTACAAGGGGAAATGGCACGgtgacGTGGCGGTAAAGATGTTGAATGTTACAGCTCCCACTCCACAGCAGCTACAAGCCTTTAAGAATGAAGTGGGTGTCCTCAGGAAAACCCGTCATGTGAATATCCTGCTGTTCATGGGCTACACCACCAAACCCCAGCTGGCTATTGTTACTCAGTGGTGCGAAGGCTCGAGTCTCTACCACCACCTGCACATCATCGAGACCAAGTTCGAGATGATCAAGCTGATCGACATTGCCCGACAGACAGCTCAGGGCATGGACTATCTGCACGCAAAGTCCATCATCCATAGAGATCTGAAGAGTAACAACATCTTTTTGCACGAGGATTTAACGGTAAAGATTGGAGATTTCGGTCTGGCTACAGTGAAGTCCCGCTGGAGCGGATCACACCAGTTTGAGCAACTTTCAGGCTCTATCTTGTGGATGgcTCCAGAAGTGATCAGACTGCAGGATAAAAACCCATATAGTTTCCAGTCGGACGTCTACGCATTCGGCATAGTGCTTTATGAGCTTATGTCAGGGGCTTTGCCTTATTCAAACATCAACAACAGAGACCAGATTATCTTCATGGTTGGCCGGGGTTACTTGTCTCCTGACTTGAGCAAGGTGCGCAGCAATTGTCCTAAGGCCATGAAGAGACTTATGGCAGATTGTCTAAAGAAAAAGCGAGAAGAAAGACCTCTTTTCCCTCAGATCTTGGCCTCCATCGAGTTATTGGCACGCTCTCTGCCCAAAATCCACCGCAGCGCCTCTGAACCGTCTCTGAACCGCGCTGGCTTCCAGACGGAGGACTTCAGCCTATACACCTGCGCTTCCCCCAAAACACCCATTCAGGCCGGTGGCTATGGTGAATTCACAGCGTTTAAATAGTGCTGCAAATCCTAAACCTCCATCCCTTGTCAGTTTTTCAGACGTCTTGTGTTCCTATGATGGGTTCATCCATAACAACACAGAAAAAGGACAAGTTTTCAAAGAATGTGCTGTTTTTCTTCCTCTTTACCCGAAGAGCTACGGCCTCAACGgaattgctttaaaataaaaacatctctGCAGGGTGtcactttacaaaaaaataaatgtcataaaCATCGCCGGACAACTCTAATACAGCTTACAAtgga
>TCONS_00055450
GTTTCTCGTGGTTTAAAATGGCGGCGTTGAGCAGCGCCGAGTCCCCACCGCCCGTCTTCAACGGAGACACCATGAACCGCGATCCGGAGCGGGACCCGGGACTGGACGAGCTGGGCGCGGGGCTCGAACCCGCCTGTCCCGGAGAAGCGGCGATCCCCGAATGTCAACAGGGCATTCCCGAGGAGATATGGAATATTAAACAgatgattaagttaactcaagAGCACCTAGAAGCCCTTTTAGATAAGTTTGGAGGAGAACACAATCCACCGTCTATATATCTAGAGGCCTATGAGGAGTACACTAGTAAGCTGGATGCATTACAGCAGCGGGAGCAGCAGCTTTTGGAAGCTATTGGGAATGGGACCGAGTTCTGCTCCTCGCCGACACCCACCCTGCTGGACGTGAAGGGACAGGGCATTCAGAGTGCCCCCACTGCCCCAAACACCCTAGCTGTCCTGCAGACGCCCACTGACGCAACACGAGGCAATCCCCGCTCGCCCCAGAAACCCATCGTCAGGGTCTTCCTGCCCAACAAACAGAGGACTGTGgttcCAGCTCGTTGTGGGATGACGGTCAGAGACTCCTTAAAGAAGGCTCTGATGATGCGAGGCTTGATCCCAGAATGCTGTGCAGTCTATAGAGTTCAGGATGGGGAGAAGAAGCCCATTGGCTGGGACACAGACATTTCCTGGTTGACGGGGGAGGAGCTTCACGTTGAAGTTTTAGAAAATGTGCCACTGACGACCCATAATTTTGTGCGAAAGACCTTCTTCACGCTGGCCTTCTGTGATTTTTGCCGGAAGCTGTTGTTTCAAGGCTTCCGCTGTCAGACGTGTGGCTATAAGTTTCACCAGCGCTGCAGCACGGAGGTCCCACTCATGTGTGTCAACTACGATCAGCTGGAtTTATTGCTGGCATCAAAATTTCTGGTGCACCACCCCATCACCCAGGAGGAGGTGTCATCAGAGGGCACGACACCCATTTCAGAGATGTGCCCCTCGCTACCACCATCCGAATCTACTGGCTCTCTGTGCCATCCTACTGTGTCCCCGTCCAAATCCATCCCTATCCCGCAATCTTTTAGACCTGGAGAAGAGGACCACCGTAACCAGTTTGGTCAGAGGGATCGCTCCTCATCAGCCCCTAACGTCCATATCAACACCATTGAGCCGGTCAACATTGATGATTTGATTCGTGATCAAGGCTTACCGAGGTCAGATGGAGGCTCAACAACAGGCCTGTCCGCCACTCCCCCTGCCTCCCTGCCAGGTTCCCTGCCCAATGTGAAGGTGTCCAAATCTCCGTGCCAACCGAGGGAGAGGAAGCCATCGTCTTCATCTGAGGACCgcaataaaatgAAAACTCTGGGTCGACGGGACTCGAGCGATGATTGGGAGATTCCAGAAGGGCAGATTACTCTGGGCCAGCGGATAGGATCTGGTTCTTTTGGGACAGTTTACAAGGGGAAATGGCACGgtgacGTGGCGGTAAAGATGTTGAATGTTACAGCTCCCACTCCACAGCAGCTACAAGCCTTTAAGAATGAAGTGGGTGTCCTCAGGAAAACCCGTCATGTGAATATCCTGCTGTTCATGGGCTACACCACCAAACCCCAGCTGGCTATTGTTACTCAGTGGTGCGAAGGCTCGAGTCTCTACCACCACCTGCACATCATCGAGACCAAGTTCGAGATGATCAAGCTGATCGACATTGCCCGACAGACAGCTCAGGGCATGGAGTGAGTCACTGCTGCTAAACACCGACCACAGATCTGCACTGTTGCACCAAAACACAATAAATTGATGATGATGAATG

Function

symbol description
braf Predicted to enable protein kinase activity. Predicted to act upstream of or within intracellular signal transduction and protein phosphorylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase).

GO:

id name namespace
GO:0035556 intracellular signal transduction biological_process
GO:0006468 protein phosphorylation biological_process
GO:0016310 phosphorylation biological_process
GO:0007165 signal transduction biological_process
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0016740 transferase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0016301 kinase activity molecular_function

KEGG:

id description
ko04010 MAPK signaling pathway
ko04013 MAPK signaling pathway - fly
ko04012 ErbB signaling pathway
ko04015 Rap1 signaling pathway
ko04068 FoxO signaling pathway
ko04024 cAMP signaling pathway
ko04150 mTOR signaling pathway
ko04214 Apoptosis - fly
ko04510 Focal adhesion
ko04810 Regulation of actin cytoskeleton
ko04650 Natural killer cell mediated cytotoxicity
ko04062 Chemokine signaling pathway
ko04910 Insulin signaling pathway
ko04914 Progesterone-mediated oocyte maturation
ko04928 Parathyroid hormone synthesis, secretion and action
ko04270 Vascular smooth muscle contraction
ko04726 Serotonergic synapse
ko04720 Long-term potentiation
ko04730 Long-term depression
ko04722 Neurotrophin signaling pathway
ko04320 Dorso-ventral axis formation
ko05200 Pathways in cancer
ko05205 Proteoglycans in cancer
ko05208 Chemical carcinogenesis - reactive oxygen species
ko05210 Colorectal cancer
ko05212 Pancreatic cancer
ko05225 Hepatocellular carcinoma
ko05226 Gastric cancer
ko05214 Glioma
ko05216 Thyroid cancer
ko05221 Acute myeloid leukemia
ko05220 Chronic myeloid leukemia
ko05218 Melanoma
ko05211 Renal cell carcinoma
ko05219 Bladder cancer
ko05215 Prostate cancer
ko05213 Endometrial cancer
ko05224 Breast cancer
ko05223 Non-small cell lung cancer
ko05161 Hepatitis B
ko05160 Hepatitis C
ko05010 Alzheimer disease
ko05022 Pathways of neurodegeneration - multiple diseases
ko05034 Alcoholism
ko04934 Cushing syndrome
ko01521 EGFR tyrosine kinase inhibitor resistance
ko01522 Endocrine resistance
ko01001 Protein kinases

ZFIN:

id description
ZDB-GENE-040805-1 Predicted to enable protein kinase activity. Predicted to act upstream of or within intracellular signal transduction and protein phosphorylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase).

Ensembl:

ensembl_id ENSDARG00000017661

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00055448 False 2986 mRNA 0.51 20 12074776 12102025
TCONS_00055449 False 2613 mRNA 0.51 19 12075040 12102036
TCONS_00055450 True 1818 lncRNA 0.53 13 12078332 12102025

Neighbor

gene id symbol gene type direction distance location
XLOC_028586 NA coding downstream 13387 12059984 ~ 12061389 (-)
XLOC_028585 NA coding downstream 16145 12057808 ~ 12058631 (-)
XLOC_028584 NA coding downstream 18349 12055935 ~ 12056427 (-)
XLOC_028583 si:dkey-222f8.3 coding downstream 34431 12033873 ~ 12040345 (-)
XLOC_028582 btbd11a coding downstream 67372 11813778 ~ 12007404 (-)
XLOC_028588 mrps33 coding upstream 231 12102267 ~ 12106039 (-)
XLOC_028589 CR792454.1 coding upstream 20758 12122794 ~ 12224825 (-)
XLOC_028590 NA coding upstream 127990 12230026 ~ 12238811 (-)
XLOC_028591 NA coding upstream 138098 12240134 ~ 12241573 (-)
XLOC_028592 cnot4b coding upstream 141662 12243698 ~ 12286067 (-)
XLOC_028580 NA non-coding downstream 271379 11758282 ~ 11803397 (-)
XLOC_028579 NA non-coding downstream 316734 11754996 ~ 11758042 (-)
XLOC_028593 NA non-coding upstream 186729 12288765 ~ 12297450 (-)
XLOC_028597 AL844512.1 non-coding upstream 493644 12595680 ~ 12595804 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
bowfin (Amia calva) AMCG00006643 braf coding CM030134.1 CM030134.1 12859177 ~ 12872555 (-)