XLOC_028602 (helb)


Basic Information

Item Value
gene id XLOC_028602
gene name helb
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007115.7
NCBI id CM002888.2
chromosome length 78093715
location 12769951 ~ 12781182 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00055472
ggctgttgtatGCAGTGTTTACAGTCATGAGTCATGTGTTGGACCGCGAAATGCAGATAACTTCAAACTGACTTTTATCAGTCAACATGGCGCTTCAAAGTCCCATTGCGGGATTAAAAACCATAACTGGTTACATTTTACCAGAAGAACAAGCTGTCCAGCCAAACAAAGACGATGGTTTAGAAAGTGAAGATGAAGAGGAGGAAGGACAGCCTGAATTTCTGGACATGAAGGAGATGAACTCGGTGTCATCTGGGGGAAACATGTTCAAATCTTTAGTGCCAACATCAAAAGAAgTGTCAATTCTGGTTGGTAAAAAGACATACAAGGTTGAGGGCCGATTCCCCCTCTGTGACCCCTGGTGGGAAGTAACCTGTACAATTCGCCTAGGCCGACTCAAGGCATTTGTTAAAGGCTACCCTTTCTATCGACTCCGCACTCATCTGAAATCAGAGGGTCGGTCACTCTTGTCTCTTTTTCTCACCGCATGTAAGGCACAAGCTGATCATGTTAAAATGTTTATGGACTGGTTGCCCACTGACAGACGTGTGGAGCTTGTTAATGTGCTGGACGTCCTGCAGGAGTTTGAAGATTCCTCACTTGAGCATGAAGCTGTGGCTCAACAGCTCAAGTCAAGTGTCAATTGTTCAGTTGTTTGGACGCACGTAAAAGCTGCCAGCTTGTACCCTGGAATCATGAAATATCTGCCAACTTTGCTGCCAGGCCAGTATCTGGACATTATAAAAAGAGCAAGAATAGAAGATATTCCAGAAACTTCAGCAATGGATGAAGACCCTCAAAACGAGCAGagaaaaacaaatgtattgtCCAAACTTGAGGagctaataaatactaataatgtgTGGAAGCTGGGCTTCAACTATATCATGTTTAAGGAATTGCATCTGATCAGGTGTGAAGCAAAACTTGAAGCCTTCAAGCTGTGCGATTTGTTTTCAGCTATCCCGCTTCTTCAGCGTAACGCGTTGATTTTATATGCAGAACTGAAGAAACACTGCAGAGTCACCGGAAGCACTTACATAACTCAGGAGATGCTTGTGGACAAAATATTTTCTGAAACCGGGGCGGATGGTGCCTGGGCAGCTCTGCACTTCCTTGTGACACAGGGGGTGCTGATGAAGGAGAGCACCAAGGTTGCACTTCGAAACctgctgaagtatgagaaaggaATTGCAGAATGTTTGACAGGCCTGGTTCAAGGAGACCCTTGGAAAATCCACCTGGATGTCAAGGAGGTTCTCCGTGAAGCTCAGATAAAAAGATTAAGAGCAAAGGCTTGTGAAAAACACAATGCAACTATGAAATCAAAGGATGATGCAAACACATCTGCCTCCGCAGCAGAAAATTCCACCGCTGTGTTTGAGCAGTTAGGCATTGATTTAGACCAGCCTGGTACTTCAAGCATGGTCCACAATGGAGAAACACCATCATGTGATGATTCTGAAAATACAACGCTCACTATTAAAGAGGAAAATCTCACATCAGACTCTGACTCAGATTTGGACATTGATCCCAGTACGATAGAGTTGGATTGTGATCAGGTGCGGGCAGCCGAAATGATGTGTGCAAATCCGGTTACAGTGATCAGTGGGAAAGGGGGTTGTGGGAAAACCACAGTGGTCAGCCTGGTGTTTAAGGCGGCCATGGAGCAGCAGACAAGCGACTTGGAGGAGGTGCAGAAGGCCTGCGAGGACTTTCAGAATGACTCTCATGGCTCTAGTAATGGGCTGGCGTTGGATGTGCACGAGGAGAAAAACCATAGCGAGAAGAGCATCAGTAATGAAAAATCTGTGGAAGTTCTCCTCACTGCTCCTACAGGCAGAGCTGCTTCACTTCTCACTAAAAGAACTGGGTTCACTGCTTACACCATGCACCAGGTGTTATGGAGTTTCATGACTGTAGATAAGGATCGAAGTGGGAATCCACAGGACTGGAAGTTCTCAAAGGTTCGGGTGCTGGTGGTTGACGAGGGAAGCTTGGTTTCTGTTCAGATCCTTCACTCCATTCTTAGCATGCTTACCAAACACGCACAACTCCAGAAGTTCATCATTTTGGGTGATGTGCGGCAGTTGCCCAGCATTGAGCCTGGAAACACACTATATGATCTGTTTGAAGGTCTCAGAAGAGTCCGCTGGGCTATTGAGATGAGGACCAATCATCGAGCCGAGTCTGAGCTCATCGTCAGAAATGCTGGACTCATCTCTGAGATgggtaaaaaaaagtattacaagCCTCTGGACTTTGATGCCACCATAGACATGACAAACCCCTCTGCAGTGCCATCCGACAAAAGATTCATTTTTATCAAAATCAGTTCGGACAATTTTTCTTTTGACCTCCAGGAAGCCATCTTGTTCCTACTTAAGGAAGCTCCTGGGCTGAAAGATCATATATTGTCACAGTTTGTGGCTTTTCGGAGGAAGGATTGTGAGTTAATCAATGAGCTTTGCTGCAGACATTATTCAAACCATACCACAAAAACTGCCAAGAAAACATTCAACTTTCAGGTAGGTGATAAAGTCTGCTGCACTAAGAATGGCTACGTCACAGACTATGATAAGAAGGAGACGTCTTTGGCGGACATCAGAGCTTCACATAATCGTGCTGAAAGTCAACAAGATGatcagaagaaagaaaagaaagagaagaaAGAGCGATTGTGCAATGGCGAAATTTTCTTCATTAAAGATGATGTGACTAAATCTGTcgagaatgaaaaaaataaaatggtgcGTCAACTGACACTCGATGATAAAAGCGACCGCCAGGTGACTTGTAACTACAAAGAGCTACAGAGAGAGTGTAAACTGCGCCATTCTTGGGCAAGAACCATTCACACCTTTCAGGGCTCAGAAGCTGAAACGATTGTATACATTCTTGGAGACAGTCCTGCCCAAAACTGGCAGCATGTTTACACCGCGGTGACTCGTGGTCAGAAGCGTGTGTATGTGGTGGGTACAGAGTATGATCTAGAAGGTGCCATCAGGAAGAGGATCACCCCTCGTAACACACGACTCTGCGGCTTTGTCAACACTAAAGTTGGCCAACAAGACCCTTTGACTACATCTGCCTCCACCCAGAGGCAAGCAGAGACTACCTTGAACCACAGTTTTGGGCATTCACAATCAACCCCAGTGGCCTCGCAAACTCCAATCCGCCCTCAGATGTTGTCCAGTACACGACCTTCATGTGCAAGAAACCTCTACACTGACAAAAATGGAGAAGGCGATCAAACGTCCAATATCTCTTTGCAAGATGACATGGCATTCAGTCAAGCCTACTCGTGGTCACCCATGGACAGCTGCGATGAGGCTGGCAGGGTGCAGAATGAAAATATGACCGAATTATCTAATCATGTTGATGATGCTTTGTTGGCAACGCTCAGCTCATCCCCAAATGAAAGCAGCAGGGGATCAAAACGCACGATTGCTGAAGACATCTACAGTACGCCATCTAAACTACCAAAGCAAACTGCTTCAGAAGAGTCTCCAATGGTCAGCTCAAGGCTGAATCTTCTGTCCCTTTCCAGTCCTGACATCAAATCCAGCCGCCAGCTCTTCCAAGACGATACACACTCTCACAGGGGTCAGCCTTAGAATGGTCAGTCTCTGACCAGACATGCCAAAGCTGGAACGATATTAATCAGTCTATCTGGAATTTTcaagaattaaaaaaagtttagcaATTATTAATTGACCTATTTCACCCACTGTTGCTTGCatctaaaaaacaatattttttaatatcttGTGGTTCTTTATAAGAGCTATGTGAGTTCTGTGTTACCTGCCAAACTGAATTGAATGCAAGGAGTACAAGATTTTTTACCAATATTTCATAAATATCCAAGGAAAGAGTTATAGACCAGGTTGGAAGACAACTGTTTTTTAAtaacatcattttaaaaacagtttttaaacatttttagattAAAACTTAAGGTGCAATTGTGTATTTTCTGTGTTTCTAATGGTTTATATTACGGTTGAAGCAATGTTTTTCCGGACAAAACGATTATGTAAAGTTTAATAACTGTAAAACCCAGATTCAGTGCTTTGGCAGAATTTGACTGTTATTGATAGCATGTGAATATTTTATAAGATCAATATATGGTTGTTTAACATCTGCTTAAGATCAATTCAATGGTTGTCATCTGAATAAACCAGACAAAACAGT
>TCONS_00055473
GAAATGCAGATAACTTCAAACTGACTTTTATCAGTCAACATGGCGCTTCAAAGTCCCATTGCGGGATTAAAAACCATAACTGGTTACATTTTACCAGAAGAACAAGCTGTCCAGCCAAACAAAGACGATGGTTTAGAAAGTGAAGATGAAGAGGAGGAAGGACAGCCTGAATTTCTGGACATGAAGGAGATGAACTCGGTGTCATCTGGGGGAAACATGTTCAAATCTTTAGTGCCAACATCAAAAGAAgTGTCAATTCTGGTTGGTAAAAAGACATACAAGGTTGAGGGCCGATTCCCCCTCTGTGACCCCTGGTGGGAAGTAACCTGTACAATTCGCCTAGGCCGACTCAAGGCATTTGTTAAAGGCTACCCTTTCTATCGACTCCGCACTCATCTGAAATCAGAGGACGTGTGGAGCTTGTTAATGTGCTGGACGTCCTGCAGGAGTTTGAAGATTCCTCACTTGAGCATGAAGCTGTGGCTCAACAGCTCAAGTCAAGTGTCAATTGTTCAGTTGTTTGGACGCACGTAAAAGCTGC

Function

symbol description
helb Predicted to enable RNA binding activity and single-stranded DNA helicase activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and negative regulation of double-strand break repair via homologous recombination. Predicted to act upstream of or within DNA replication, synthesis of RNA primer. Predicted to be active in nucleolus. Is expressed in several structures, including germ ring; intermediate cell mass of mesoderm; margin; tail bud; and ventral mesoderm. Orthologous to human HELB (DNA helicase B).

GO:

id name namespace
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) biological_process
GO:2000042 negative regulation of double-strand break repair via homologous recombination biological_process
GO:0006261 DNA-dependent DNA replication biological_process
GO:0006269 DNA replication, synthesis of RNA primer biological_process
GO:0005622 intracellular anatomical structure cellular_component
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0017116 single-stranded DNA helicase activity molecular_function
GO:0003678 DNA helicase activity molecular_function
GO:0003723 RNA binding molecular_function

KEGG:

id description
ko03032 DNA replication proteins

ZFIN:

id description
ZDB-GENE-030729-16 Predicted to enable RNA binding activity and single-stranded DNA helicase activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and negative regulation of double-strand break repair via homologous recombination. Predicted to act upstream of or within DNA replication, synthesis of RNA primer. Predicted to be active in nucleolus. Is expressed in several structures, including germ ring; intermediate cell mass of mesoderm; margin; tail bud; and ventral mesoderm. Orthologous to human HELB (DNA helicase B).

Ensembl:

ensembl_id ENSDARG00000053127

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00055472 False 4197 mRNA 0.44 13 12769951 12781182
TCONS_00055473 True 541 processed_transcript 0.45 4 12777709 12781135

Neighbor

gene id symbol gene type direction distance location
XLOC_028601 dera coding downstream 3533 12755136 ~ 12766418 (-)
XLOC_028600 NA coding downstream 25598 12741362 ~ 12744353 (-)
XLOC_028599 mgst1.2 coding downstream 44438 12718965 ~ 12725513 (-)
XLOC_028598 mgst1.1 coding downstream 51584 12715695 ~ 12718367 (-)
XLOC_028597 AL844512.1 coding downstream 174147 12595680 ~ 12595804 (-)
XLOC_028603 irak3 coding upstream 952 12782134 ~ 12795489 (-)
XLOC_028604 hmga2 coding upstream 38090 12819272 ~ 12862087 (-)
XLOC_028605 BX119963.4 coding upstream 92800 12873982 ~ 12883327 (-)
XLOC_028606 msrb3 coding upstream 109486 12890668 ~ 12914307 (-)
XLOC_028607 lemd3 coding upstream 135982 12917164 ~ 12930086 (-)
XLOC_028593 NA non-coding downstream 472501 12288765 ~ 12297450 (-)
XLOC_028591 NA non-coding downstream 528378 12240134 ~ 12241573 (-)
XLOC_028590 NA non-coding downstream 531140 12230026 ~ 12238811 (-)
XLOC_028609 NA non-coding upstream 207796 12988978 ~ 12989698 (-)
XLOC_028611 NA non-coding upstream 242325 13023507 ~ 13024168 (-)
XLOC_028613 NA non-coding upstream 564490 13345672 ~ 13393170 (-)
XLOC_028614 NA non-coding upstream 696047 13477229 ~ 13478821 (-)

Expression


Co-expression Network