XLOC_002865 (dgat2)


Basic Information

Item Value
gene id XLOC_002865
gene name dgat2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007121.7
NCBI id CM002894.2
chromosome length 45420867
location 32501961 ~ 32524771 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00005303
GCGGCCGACGCCAGTACAGAGAGAGAGATGCTGTAGAGCAGCTCAACCTTCAGCTCACATTTCTTTACTTTACCTTAATTTATTCCTCTAGCCTCAACCATGAAGACCATACTTGCTGCATATTCCGGTGTCAAAAAGGGCTCGGGCTCCAGCATCCTCTCTGCCTTACACGACCTGCCCACCGTCCCGTGGCTGACCCGATCCAAAATGGTGAAGCATCTGCAGGTGATCTCCGTGCTGCAGTTTATCATGACATTTCTTACCATGGGCATTGCTTGCTCTTTGCTGCTGATGTACATGTTTTGCACAGACTTCTGGGTCATTTCTGTGCTTTACGTTGCCTGGCTTATCTATGACTGGAACACCCCTGGACAAGACATCTTTATCTCAGGAGGCCGCAGATCGACCTGGGTGAGAGACTGGACTGTGTGGAAATACATGAGAGACTATTTTCCCATAAGACTCATCAAGACGCATAACCTGCTTCCCAGCCGAAACTACATTTTTGGCTACCACCCTCATGGCATCTTGTGTTTTGGGGCTTTTTGTAACTTCGGGACAGAAGCCACAGGATTCACCAAGGTGTTCCCAGGAATCAAGCCATCTCTGGCCACATTGGCTGGAAACTTTCGCTTGCCCATGTTCAGGGAATACCTGATGTGCGGAGGAATCTGCCCAGTAAACCGAAACTCTATCGACTACCTCCTGTCCAGTAACGGCACAGGCAACGCTGTGGTCATCGTGATCGGAGGAGCTGCAGAATCCCTGGACTGTGCACCAGGAAGAAACTCTGTCATGCTGAAAAAACGCAAAGGCTTTGTGAAACTGGCTCTAAAGCAAGGTGCGGATCTGGTGCCAGTTTACTCCTTTGGGGAGAATGAGGTTTACAAACAGCTGATTTTTGAAGAAGGGTCTTGGTGGCGTACTATTCAGAGGAAACTTCAGAAGTTTTTAGGCTTTGCCCCTTGTTTGTTTCATGGCTGTGGACTGTTTTTCCCAGAGTCCTGGGGTCTGGTGCCTTACTGCAAACCTATCACTACAGTTGTTGGTGAACCTATCACTGTGCCAAAGATAGAGGAGCCGACTCAGGACGTCATAGACATGTACCACGCCATGTACATCAGGTCCCTAAAGTCTCTCTTTGACAATTACAAGACCCGCTTCGGTCTGAATGAGAGCGATACCCTTATCATTCACTGAGGAATGATGATAACTGTCCAAACGAACACTCTGGAATATCATTCAGCCAACGTAAATGCCCATTCAGAGAAGGTGCTGTTTCTCTTCATTCAATACTGTATATCTACTGAAATCCGCTGCAGTGATTTCAGCTTACGATACTTCTGCTACTTCTGCTGATTTTTGCACAGACTGATGCCAAATATTCACCTTTTTCTTACGCCCCATGATGCTTTGCATGAATTATGGGAGGATCTTCTGCTAAACTGTAAATAATCagctatttttaagtattttcttttatttaaaccgTTTACAATGAGGTGTCCTCACATTACACCCATTAAATAGTAACCTTATTAAACCACTTTCAGCAGACCACAAATGACCCCAAAAactcaacagtaaaaaaaa
>TCONS_00005304
AGAGGGTATAGCATATAAATAGcacattatatttaatatagGCTATTGTTAATAAATAACAAAGCTGAAGACCAGACAGCAGCAAAGGTGAACGTAGTCTCTGCCATCTGACCGCTGGCCAAGCCTGGCATGAAGAACAGGGTAACAAAGGTCACTGCAGTAGCAACACTGGCCTTGACtttgggaaaaagagaaattggGACATTATGAAACAGCTAATGTCCCTAAAGGATATTCAATATCACTTTTTGCCCTTCATTTCTCAACTCTGGAACTGCTCTTAAGACTGCTGAAATTATGAAGGACgtgcaaattattatttattaatttaaatgatttaattctaGACTACATAAATCTGAAATAAGTTAACAAACTGAGGAAgcaatgcttgttttttttagagTGAACACAGATAATTAGTGTTTGTCAAAAAAATCCCGTGGGAGGGGCTAAAGTATCCTCCATCTGATTGGCAGAGCGCCCAGTTTACCTTCACAAACCTTTAAAACCTCCTGATCAGATGAAGCGATAAGCAGTCAGTGCCCACAGCGTAACGCGTAACCGTGACCCCATCCAGTCAGCTGCTGCAGACAGAAATCTATAAGACAGAAtagtcttttttaaataaagcttgACAATAGCTCTTTTAACAGGCGGTTGCGGTTTTACTGACAGCGTGTTTTACGCTCCTCCCCCTGAGGTGCTTAAATGACAGGCGCGCGCCTGTGAGCTCGCGGCCGACGCCAGTACAGAGAGAGAGATGCTGTAGAGCAGCTCAACCTTCAGCTCACATTTCTTTACTTTACCTTAATTTATTCCTCTAGCCTCAACCATGAAGACCATACTTGCTGCATATTCCGGTGTCAAAAAGGGCTCGGGCTCCAGCATCCTCTCTGCCTTACACGACCTGCCCACCGTCCCGTGGCTGACCCGATCCAAAATGGTGAAGCATCTGCAGGTGATCTCCGTGCTGCAGTTTATCATGACATTTCTTACCATGGGCATTGCTTGCTCTTTGCTGCTGATGTACATGTTTTGCACAGACTTCTGGGTCATTTCTGTGCTTTACGTTGCCTGGCTTATCTATGACTGGAACACCCCTGGACAAGGAGGCCGCAGATCGACCTGGGTGAGAGACTGGACTGTGTGGAAATACATGAGAGACTATTTTCCCATAAGACTCATCAAGACGCATAACCTGCTTCCCAGCCGAAACTACATTTTTGGCTACCACCCTCATGGCATCTTGTGTTTTGGGGCTTTTTGTAACTTCGGGACAGAAGCCACAGGATTCACCAAGGTGTTCCCAGGAATCAAGCCATCTCTGGCCACATTGGCTGGAAACTTTCGCTTGCCCATGTTCAGGGAATACCTGATGTGCGGAGGAATCTGCCCAGTAAACCGAAACTCTATCGACTACCTCCTGTCCAGTAACGGCACAGGCAACGCTGTGGTCATCGTGATCGGAGGAGCTGCAGAATCCCTGGACTGTGCACCAGGAAGAAACTCTGTCATGCTGAAAAAACGCAAAGGCTTTGTGAAACTGGCTCTAAAGCAAGGTGCGGATCTGGTGCCAGTTTACTCCTTTGGGGAGAATGAGGTTTACAAACAGCTGATTTTTGAAGAAGGGTCTTGGTGGCGTACTATTCAGAGGAAACTTCAGAAGTTTTTAGGCTTTGCCCCTTGTTTGTTTCATGGCTGTGGACTGTTTTTCCCAGAGTCCTGGGGTCTGGTGCCTTACTGCAAACCTATCACTACAGTTGTTGGTGAACCTATCACTGTGCCAAAGATAGAGGAGCCGACTCAGGACGTCATAGACATGTACCACGCCATGTACATCAGGTCCCTAAAGTCTCTCTTTGACAATTACAAGACCCGCTTCGGTCTGAATGAGAGCGATACCCTTATCATTCACTGA

Function

symbol description
dgat2 Predicted to enable diacylglycerol O-acyltransferase activity. Acts upstream of or within lipid homeostasis; regulation of response to endoplasmic reticulum stress; and response to (R)-carnitine. Predicted to be located in lipid droplet and perinuclear endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in male organism. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Orthologous to several human genes including DGAT2 (diacylglycerol O-acyltransferase 2).

GO:

id name namespace
GO:0006629 lipid metabolic process biological_process
GO:0061959 response to (R)-carnitine biological_process
GO:0006071 glycerol metabolic process biological_process
GO:0006651 diacylglycerol biosynthetic process biological_process
GO:1905897 regulation of response to endoplasmic reticulum stress biological_process
GO:0055088 lipid homeostasis biological_process
GO:0019432 triglyceride biosynthetic process biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005811 lipid droplet cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:1990578 perinuclear endoplasmic reticulum membrane cellular_component
GO:0005737 cytoplasm cellular_component
GO:0016740 transferase activity molecular_function
GO:0016746 transferase activity, transferring acyl groups molecular_function
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function
GO:0050252 retinol O-fatty-acyltransferase activity molecular_function
GO:0008374 O-acyltransferase activity molecular_function
GO:0004144 diacylglycerol O-acyltransferase activity molecular_function

KEGG:

id description
ko00561 Glycerolipid metabolism
ko04975 Fat digestion and absorption

ZFIN:

id description
ZDB-GENE-050913-15 Predicted to enable diacylglycerol O-acyltransferase activity. Acts upstream of or within lipid homeostasis; regulation of response to endoplasmic reticulum stress; and response to (R)-carnitine. Predicted to be located in lipid droplet and perinuclear endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in male organism. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Orthologous to several human genes including DGAT2 (diacylglycerol O-acyltransferase 2).

Ensembl:

ensembl_id ENSDARG00000018846

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00005303 False 1593 mRNA 0.46 8 32501961 32524035
TCONS_00005304 True 1921 mRNA 0.46 8 32502354 32524771

Neighbor

gene id symbol gene type direction distance location
XLOC_002864 uvrag coding downstream 7462 32264857 ~ 32494499 (-)
XLOC_002863 NA coding downstream 251115 32216413 ~ 32250846 (-)
XLOC_002862 NA coding downstream 417337 32077811 ~ 32084624 (-)
XLOC_002861 vps26bl coding downstream 696038 31800212 ~ 31805923 (-)
XLOC_002860 fez1 coding downstream 719345 31738501 ~ 31782616 (-)
XLOC_002866 mogat2 coding upstream 10043 32534814 ~ 32610776 (-)
XLOC_002867 NA coding upstream 59914 32584685 ~ 32591462 (-)
XLOC_002868 umodl1 coding upstream 88935 32613706 ~ 32639941 (-)
XLOC_002869 atg101 coding upstream 132725 32657496 ~ 32663759 (-)
XLOC_002870 NA coding upstream 152039 32676810 ~ 32678245 (-)
XLOC_002858 NA non-coding downstream 1206955 31262852 ~ 31295006 (-)
XLOC_002854 CT737197.1 non-coding downstream 1970704 30531143 ~ 30531257 (-)
XLOC_002845 CU861448.1 non-coding downstream 2793779 29708068 ~ 29708182 (-)
XLOC_002871 NA non-coding upstream 255109 32779880 ~ 32780290 (-)
XLOC_002875 NA non-coding upstream 370226 32894997 ~ 32896944 (-)
XLOC_002877 NA non-coding upstream 633818 33158589 ~ 33164573 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000304_15703390_15711806 DGAT2 coding CI01000304 null 15703172 ~ 15712119 (-)