XLOC_028714 (sco2)


Basic Information

Item Value
gene id XLOC_028714
gene name sco2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007115.7
NCBI id CM002888.2
chromosome length 78093715
location 18453702 ~ 18455480 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00055670
GAATCGCAAGTGTTCCGCAGCCTCACTGTTGTACATGTAACATGTGAAGATCGAGTTTACATCCTGCATTGAGGACAGGCGAGTGAAATCCCAAGaGGATGTTAAGACTGAGGGTATTCGACAGACATAAGAGGTTATGGAGCGTCCTGCAGTCAACAATAAGGGGAAACAACATTTCAAATCACATCCCAAACACCACATGCAGATCTTCAGCTCCACCACATTTATGTGCACGACAAAGAGCCTTTTACTCTCAAAACTCCCCTAAAACTCCAAATCCAGGCTCGTCCGCAGGCATCAAACTGCGCACACGCTTGGTGGTGACGCTGCTTTTTGGAGGTGGCATCATTGGCACTTGGTGGTACGTGCATCAGGAGAAAGAAAAGAGGATTCAGATGCAAAGACTGGAGCAGTTGCGAAAAGTGGCTCTCGGACAGGGAGATTTCCATTTGCTTGATCATACGGGACAGCGCAGAACCAAACGAGACTTTCTAGGACACTGGGTGCTGTTATATTTCGGTTTTACCCACTGTCCTGATATCTGTCCTGATGAGCTGGAGAAGTTGACCAGCGTGGTGCATATTTTGGATAAAGACCCAAGCTTGCCTTCTGTTCAGCCTCTTTTCATCACTGTTGACCCAGAGAGAGATGATGTTTCTGCTATGGCCAGGTATGTGAAAGATTTTCATCCCCGTTTGGTTGGACTGACCGGGAGCGCGGAGGAAGTGAAGCAGGCGGGACGGGATTTTAGGGTTTACGCCAGTAATGGGCCCAAAGATGAGGATGGGGACTATATTGTGGATCACAGCATAGTCATCTACCTGGTCAACCCGGATGGACTGTTTATCGACTATTACAATAGGATGAAAAATGACACCCAGATTGCTGAGAGTATTCGCAATCACATGAAGACCTTTGTTAGATTGTTTCCTGATTAATCTGAGCGAGACGAGTTGTGAGTGTAAATAAAGGTAAATTTTGAAAT
>TCONS_00055671
aGGATGTTAAGACTGAGGGTATTCGACAGACATAAGAGGTTATGGAGCGTCCTGCAGTCAACAATAAGGGGAAACAACATTTCAAATCACATCCCAAACACCACATGCAGATCTTCAGCTCCACCACATTTATGTGCACGACAAAGAGCCTTTTACTCTCAAAACTCCCCTAAAACTCCAAATCCAGGCTCGTCCGCAGGCATCAAACTGCGCACACGCTTGGTGGTGACGCTGCTTTTTGGAGGTGGCATCATTGGCACTTGGTGGTACGTGCATCAGGAGAAAGAAAAGAGGATTCAGATGCAAAGACTGGAGCAGTTGCGAAAAGTGGCTCTCGGACAGGGAGATTTCCATTTGCTTGATCATACGGGACAGCGCAGAACCAAACGAGACTTTCTAGGACACTGGGTGCTGTTATATTTCGGTTTTACCCACTGTCCTGATATCTGTCCTGATGAGCTGGAGAAGTTGACCAGCGTGGTGCATATTTTGGATAAAGACCCAAGCTTGCCTTCTGTTCAGCCTCTTTTCATCACTGTTGACCCAGAGAGAGATGATGTTTCTGCTATGGCCAGGTATGTGAAAGATTTTCATCCCCGTTTGGTTGGACTGACCGGGAGCGCGGAGGAAGTGAAGCAGGCGGGACGGGATTTTAGGGTTTACGCCAGTAATGGGCCCAAAGATGAGGATGGGGACTATATTGTGGATCACAGCATAGTCATCTACCTGGTCAACCCGGATGGACTGTTTATCGACTATTACAATAGGATGAAAAATGACACCCAGATTGCTGAGAGTATTCGCAATCACATGAAGACCTTTGTTAGATTGTTTCCTGATTAA

Function

symbol description
sco2 Predicted to enable protein-disulfide reductase activity. Predicted to be involved in eye development and mitochondrial cytochrome c oxidase assembly. Predicted to act upstream of or within cellular copper ion homeostasis and respiratory chain complex IV assembly. Predicted to be integral component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease; fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency 1; hypertrophic cardiomyopathy; and myopia. Orthologous to human SCO2 (synthesis of cytochrome C oxidase 2).

GO:

id name namespace
GO:0008535 respiratory chain complex IV assembly biological_process
GO:0001654 eye development biological_process
GO:0006825 copper ion transport biological_process
GO:0033617 mitochondrial cytochrome c oxidase assembly biological_process
GO:0006878 cellular copper ion homeostasis biological_process
GO:0005743 mitochondrial inner membrane cellular_component
GO:0031305 integral component of mitochondrial inner membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005507 copper ion binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0015035 protein disulfide oxidoreductase activity molecular_function

KEGG:

id description
ko05230 Central carbon metabolism in cancer
ko03110 Chaperones and folding catalysts
ko03029 Mitochondrial biogenesis

ZFIN:

id description
ZDB-GENE-041210-173 Predicted to enable protein-disulfide reductase activity. Predicted to be involved in eye development and mitochondrial cytochrome c oxidase assembly. Predicted to act upstream of or within cellular copper ion homeostasis and respiratory chain complex IV assembly. Predicted to be integral component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease; fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency 1; hypertrophic cardiomyopathy; and myopia. Orthologous to human SCO2 (synthesis of cytochrome C oxidase 2).

Ensembl:

ensembl_id ENSDARG00000045555

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00055670 False 985 mRNA 0.46 2 18453702 18455480
TCONS_00055671 True 843 mRNA 0.47 1 18453749 18454591

Neighbor

gene id symbol gene type direction distance location
XLOC_028713 socs2 coding downstream 16803 18432182 ~ 18436899 (-)
XLOC_028712 cradd coding downstream 37136 18383253 ~ 18416566 (-)
XLOC_028711 plxnc1 coding downstream 137790 18281954 ~ 18315912 (-)
XLOC_028710 uhrf1bp1l coding downstream 172542 18207655 ~ 18281160 (-)
XLOC_028708 anks1b coding downstream 251411 17886838 ~ 18202291 (-)
XLOC_028715 rint1 coding upstream 44532 18500012 ~ 18512550 (-)
XLOC_028716 cdkn1ba coding upstream 137263 18592743 ~ 18595525 (-)
XLOC_028717 CDPF1 coding upstream 141682 18597162 ~ 18606573 (-)
XLOC_028718 pparaa coding upstream 154059 18609539 ~ 18635005 (-)
XLOC_028719 dre-let-7b coding upstream 197668 18653148 ~ 18653241 (-)
XLOC_028709 BX901882.1 non-coding downstream 264182 18189406 ~ 18189520 (-)
XLOC_028707 NA non-coding downstream 570772 17875071 ~ 17882930 (-)
XLOC_028702 BX890572.1 non-coding downstream 715890 17736443 ~ 17737812 (-)
XLOC_028696 NA non-coding downstream 824258 17571295 ~ 17629444 (-)
XLOC_028690 NA non-coding downstream 1237479 17113379 ~ 17216223 (-)
XLOC_028720 dre-let-7a-3 non-coding upstream 198675 18654155 ~ 18654261 (-)
XLOC_028721 NA non-coding upstream 199202 18654682 ~ 18679692 (-)
XLOC_028722 NA non-coding upstream 257283 18712763 ~ 18714926 (-)
XLOC_028730 dre-mir-129-1 non-coding upstream 591986 19047466 ~ 19047555 (-)

Expression


Co-expression Network