LOC110486545 (grb2)


Basic Information

Item Value
gene id LOC110486545
gene name grb2
gene type coding
species rainbow trout (Oncorhynchus mykiss)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_048577.1
NCBI id CM023231.2
chromosome length 73332040
location 45484798 ~ 45524322 (+)
genome version USDA_OmykA_1.1_2020_rainbow_trout_Genome

Sequence

>XM_021558235.2
TGGGCCGGTCAGACACTCTGCTCACAGCGCGAGGCAGGAGCCGAAGCAGCAGCAGCACCCAAAGCATCTGGAAGGAAGCGGAAATAAACGTCGCTGGCTAGTTCGAGTTTAAGCAAAAACAGACGGATTTTGTACATTTACCTCCACTAACAAAACTATAAAGTGTGGATTCTAAACAATAAGGACATTTGATCAAGCAAGAAGTTTACATTTCACAGGTTAACTGGCGGATACCTTCTGTGAGCTTTATGTGAGGATCCATCCCTAAAGGAACGGGTCATAGACGGGAGGAGCGACTCGGAGCAAGCAACCGATCACGGAATTCTTGaacagttattttttttatactgaaGTTACTGGTCTCCACACATCAACGACAGGGAATAAAACAGCATTCACCCTCACAAGTACCATAAACCCACGGTTATACACAGTTATCCAACAATCCGTACCATGGAGGCCGTTGCCAAATACGATTTCAAAGCCACTGCTGACGACGAGTTAAGTTTTAAACGTGGGGAAGTTCTAAAGGTATTAAATGAAGAGTGTGACCAGAACTGGTACAAAGCAGAGTTGAACGGGAAAGACGGCTTCATCCCCAAGAACTACATAGAGATGAAAGCACATCCGTGGTTCTTTGGCAAGATCCCCCGTGCCAAGGCAGAGGAGATGTTGAACAAACAGAGGCACGACGGGGCCTTCCTCATCCGAGAGAGTGAGAGTGCGCCAGGggacttctccctctctgtcaaGTTTGGAAATGACGTTCAGCACTTCAAAGTCCTGCGTGATGGGGCAGGAAAGTACTTCCTGTGGGTGGTGAAGTTCAACTCGCTCAACGAGCTGGTGGACTACCACCGCTCCACCTCTGTATCCCGCAACCAGCAGATCTTCCTGCGTGACATTGAGCAGGTCCCCCAGCATCCCACATATGTACAGGCTCTCTTTGACTTTGACCCCCAGGAGGATGGTGAGCTGGGCTTCCGACGCGGAGACTTCATCCAGGTCCTGGACAACTCTGACCCTAactggtggaagggaggatgccACGGGCTGACAGGGATGTTCCCCCGTAACTACGTGACACCAGTCAACCGGaacatgtaaacaaacacacacatatcaacAACCACCCCATATCAACCCATCAAGAAGACatcaggaacagagagggagaatgcaACAAGGAATGAAAAATGGAGGAGGAGTTCTGTTGACGGCATCACCTTGTCGGTGGCAGCTGAGCAAAGCCAACTTTTAACACTGAGAATGTTCGCCTCCATAGTGAACGCTTCAGTCAGAACTGAACTGTCATTGAGGAAAAACACAGAGAAACTAAGCATAGTGCACCAAAAGTGAAGATAATGAGAATGATTCTATACCTAGACTCCCACATCTGCTTCTGTCCTCTCTACATCTTTACATGcgttttcttttccttttttgcTGCATGTTTTAATCACCTAAATGAAATACCAATAAATCCTAACGCtgttttaaataaaaatacatgtacaaatattttaaaaagtgattgaaaaaaaaataaaaaaaatactgatGTTATCTGCAGCAAGTTAACAAGTCCAATATCATTGGCATTGTACTTCAGCCCAGGGCTGTATAAataaatcacctacagtataGAGAGAATCCATTTTTTaagaatatatattatatatatttgtatgtgtTTTACCAGTCATCACaaattgtattgttttttttccatttgtaaattatgttaaAAAATGTTAGTCTGGAATAGACCTAGTAGCTCTGGGATAAGCTGAATTGTCAGTATAATTTTTCCTGAATTATTTGAGGGCTCCCAGATAAAATGGCATGATATTTAAAACATGAAATAATTTCCTAATTTTCTGTTATTTCTAACAAAACCAATCGTGTCAGGAAGCTAACGCCGAGCAGCGAGTAGAGCCATGTATGCTGCATGAGCTGTTGTATTATGAAACCCTGTAAAAGGCCAGCCACCTTTTGAAGCCAATGTATTTATTGCAGCCATTTTACTCTTAGGCCGTGAATGTAGCTGACTGAGTCCAGAGACATTGACATGAGGGAAGCAAGGTCGGAGAACTGAACTACACAACTGCAAGGGATTTCCGAGAAGTGCTGAATTAGTAATGGTGTCAATATAAAATTATATAGAGAGATGTATGAAAAATATGCATCAATCACACACGCGCATACATTAACAGTCCCCTCCTTGTTAGACTCACACATAACAAGTAGGTGAGTTGGATAATCACATGATGGCGTGATAAACAGTTTGAGAAAATTGTGTCTTTTATGCTAAAAGTTGAGAGATCAGCTTGACCAATGTTGTTTTTCTCTCGTCTGTGGCGTGTCAAGCACTTTTTATGTTAAGCATTTGATTTCTGGTCCGGTGTGTGtttttttcagtgtgtgtttagtttgttCTCTCTGGATAGTGCCTTTCTCTCTGGTGTTTCAGTGTCTCCGACCTGCTGCTTTGAGCCCCTTTGTGGGGCCCGTCAATCCTGCAGTGAGAAACCATGTACATAATCCAACCTGTCCCATCAACGccacatctccctccctccctgtgcccTTTCCAACATGGAACTTTTCTTATTTAAGTGTATCTTGCCTTCTCTTCCCTATTGATACTGTTTTTTTTTGCctcttttttttaatttaatttttaaataaaaatgcaaTTCTACAAATAAAAAAAGAACAACCATGTGGTGTGGTC
>XM_021558236.2
GTCACCATAGTCCAACAGAGGGAGGACACAGGACATTTTCGGAGCGGGAAAAGCAGGACTTGTTGCGGTGGAGAAAGCCCAGTCTGGATTAGATTTTGTGGTTATTGAAATGGGTGCTGAAGTTGAGTTATTCATCAAGCCAGGTGCCCAGGTATTAAATGAAGAGTGTGACCAGAACTGGTACAAAGCAGAGTTGAACGGGAAAGACGGCTTCATCCCCAAGAACTACATAGAGATGAAAGCACATCCGTGGTTCTTTGGCAAGATCCCCCGTGCCAAGGCAGAGGAGATGTTGAACAAACAGAGGCACGACGGGGCCTTCCTCATCCGAGAGAGTGAGAGTGCGCCAGGggacttctccctctctgtcaaGTTTGGAAATGACGTTCAGCACTTCAAAGTCCTGCGTGATGGGGCAGGAAAGTACTTCCTGTGGGTGGTGAAGTTCAACTCGCTCAACGAGCTGGTGGACTACCACCGCTCCACCTCTGTATCCCGCAACCAGCAGATCTTCCTGCGTGACATTGAGCAGGTCCCCCAGCATCCCACATATGTACAGGCTCTCTTTGACTTTGACCCCCAGGAGGATGGTGAGCTGGGCTTCCGACGCGGAGACTTCATCCAGGTCCTGGACAACTCTGACCCTAactggtggaagggaggatgccACGGGCTGACAGGGATGTTCCCCCGTAACTACGTGACACCAGTCAACCGGaacatgtaaacaaacacacacatatcaacAACCACCCCATATCAACCCATCAAGAAGACatcaggaacagagagggagaatgcaACAAGGAATGAAAAATGGAGGAGGAGTTCTGTTGACGGCATCACCTTGTCGGTGGCAGCTGAGCAAAGCCAACTTTTAACACTGAGAATGTTCGCCTCCATAGTGAACGCTTCAGTCAGAACTGAACTGTCATTGAGGAAAAACACAGAGAAACTAAGCATAGTGCACCAAAAGTGAAGATAATGAGAATGATTCTATACCTAGACTCCCACATCTGCTTCTGTCCTCTCTACATCTTTACATGcgttttcttttccttttttgcTGCATGTTTTAATCACCTAAATGAAATACCAATAAATCCTAACGCtgttttaaataaaaatacatgtacaaatattttaaaaagtgattgaaaaaaaaataaaaaaaatactgatGTTATCTGCAGCAAGTTAACAAGTCCAATATCATTGGCATTGTACTTCAGCCCAGGGCTGTATAAataaatcacctacagtataGAGAGAATCCATTTTTTaagaatatatattatatatatttgtatgtgtTTTACCAGTCATCACaaattgtattgttttttttccatttgtaaattatgttaaAAAATGTTAGTCTGGAATAGACCTAGTAGCTCTGGGATAAGCTGAATTGTCAGTATAATTTTTCCTGAATTATTTGAGGGCTCCCAGATAAAATGGCATGATATTTAAAACATGAAATAATTTCCTAATTTTCTGTTATTTCTAACAAAACCAATCGTGTCAGGAAGCTAACGCCGAGCAGCGAGTAGAGCCATGTATGCTGCATGAGCTGTTGTATTATGAAACCCTGTAAAAGGCCAGCCACCTTTTGAAGCCAATGTATTTATTGCAGCCATTTTACTCTTAGGCCGTGAATGTAGCTGACTGAGTCCAGAGACATTGACATGAGGGAAGCAAGGTCGGAGAACTGAACTACACAACTGCAAGGGATTTCCGAGAAGTGCTGAATTAGTAATGGTGTCAATATAAAATTATATAGAGAGATGTATGAAAAATATGCATCAATCACACACGCGCATACATTAACAGTCCCCTCCTTGTTAGACTCACACATAACAAGTAGGTGAGTTGGATAATCACATGATGGCGTGATAAACAGTTTGAGAAAATTGTGTCTTTTATGCTAAAAGTTGAGAGATCAGCTTGACCAATGTTGTTTTTCTCTCGTCTGTGGCGTGTCAAGCACTTTTTATGTTAAGCATTTGATTTCTGGTCCGGTGTGTGtttttttcagtgtgtgtttagtttgttCTCTCTGGATAGTGCCTTTCTCTCTGGTGTTTCAGTGTCTCCGACCTGCTGCTTTGAGCCCCTTTGTGGGGCCCGTCAATCCTGCAGTGAGAAACCATGTACATAATCCAACCTGTCCCATCAACGccacatctccctccctccctgtgcccTTTCCAACATGGAACTTTTCTTATTTAAGTGTATCTTGCCTTCTCTTCCCTATTGATACTGTTTTTTTTTGCctcttttttttaatttaatttttaaataaaaatgcaaTTCTACAAATAAAAAAAGAACAACCATGTGGTGTGGTC

Function

symbol description
grb2 Enables several functions, including SH3 domain binding activity; insulin receptor substrate binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to ionizing radiation; signal transduction in response to DNA damage; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of or within actin cytoskeleton reorganization. Located in endosome; nucleolus; and nucleoplasm. Part of COP9 signalosome and Grb2-EGFR complex. Implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Biomarker of endometrial carcinoma.

NR:

description
growth factor receptor-bound protein 2 isoform X2

GO: NA

KEGG:

id description
K20522 LSB1_2; LAS seventeen-binding protein 1/2

RNA

RNA id representative length rna type GC content exon number start site end site
XM_021558235.2 False 2737 mRNA 0.42 6 45484798 45524322
XM_021558236.2 True 2357 mRNA 0.42 5 45504918 45524322

Neighbor

gene id symbol gene type direction distance location
usp43b LOC106601383 coding upstream 33056 45358739 ~ 45451742 (+)
LOC110486541 LOC106607062 coding upstream 216378 45223469 ~ 45268420 (+)
hmox1a LOC106607056 coding upstream 330066 45152082 ~ 45154732 (+)
LOC110486534 NA coding upstream 343858 45135680 ~ 45140940 (+)
zgc:162612 LOC106607050 coding upstream 369651 45111643 ~ 45115147 (+)
trnas-aga-61 NA coding downstream 2483 45526805 ~ 45526886 (+)
LOC110485192 LOC106601391 coding downstream 5076 45529398 ~ 45554103 (+)
LOC110486547 LOC106607066 coding downstream 31496 45555818 ~ 45559601 (+)
LOC110486546 LOC106601396 coding downstream 35612 45559934 ~ 45614619 (+)
LOC110486548 LOC106607064 coding downstream 97211 45621533 ~ 45627020 (+)
G1179369 NA non-coding upstream 13383 45471185 ~ 45471415 (+)
G1179360 NA non-coding upstream 22493 45462053 ~ 45462305 (+)
G1179359 NA non-coding upstream 23097 45461502 ~ 45461701 (+)
G1179352 NA non-coding upstream 26983 45457607 ~ 45457815 (+)
G1179350 NA non-coding upstream 28022 45456534 ~ 45456776 (+)
G1179402 NA non-coding downstream 8396 45532718 ~ 45532950 (+)
G1179446 NA non-coding downstream 129445 45653767 ~ 45654496 (+)
G1179445 NA non-coding downstream 130705 45655027 ~ 45656039 (+)
G1179448 NA non-coding downstream 138540 45662862 ~ 45663122 (+)
G1179452 NA non-coding downstream 145238 45669560 ~ 45669987 (+)
G1179362 NA other upstream 21855 45462588 ~ 45462943 (+)
G1179156 NA other upstream 171765 45312330 ~ 45313033 (+)
LOC110486526 smarca4 other upstream 515079 44967368 ~ 44996127 (+)
LOC110485188 LOC106601310 other upstream 558481 44878675 ~ 44943951 (+)
G1178425 NA other upstream 620615 44859869 ~ 44864183 (+)
LOC118936304 LOC106601427 other downstream 649706 46173911 ~ 46176562 (+)
G1180047 NA other downstream 714822 46239144 ~ 46273601 (+)
LOC110485193 LOC106601421 other downstream 807396 46302751 ~ 46336386 (+)
G1181472 NA other downstream 1849841 47374163 ~ 47374477 (+)

Expression


Co-expression Network