XLOC_032258 (cish)


Basic Information

Item Value
gene id XLOC_032258
gene name cish
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007117.7
NCBI id CM002890.2
chromosome length 60270059
location 41503854 ~ 41506749 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00062998
AACATCAGGAAGCAATTACCGACAATAAAACTCCCAAATGAGTCATTGCAGGCTCATTCCAGCGCTAGTTCGTTACTCACGAGACCACCGTATGCTAGACTGAGAGAGAGAATTCTGGGCATCGATTCTGTGGCTTTCGCGGAGGCGCGCTGCCGATGTCGTCACAGGCGCTAAACACGGGGAGATTCTCAGAAAAGCAATCCCGAGAAGTCAGACAAACTGAACAAGGCAAACCCTGCAGTGCTCAGCCTGTCGTTCAGTTTTAGGGCACGAGCTAAACAGAAACGCCGCTCGTTTTCGAGAAGCATGTCCGCGTTATCAACTCGAGCAGTTTGTTAAACAAATTGGCGGACGGGTCGCGCGCACTTGTGTGACAGCCAGAGACAGAAGTACTGACTGAGTGTCCGGACGCTCCTCACCGCCGCCGAGATCCGCTGATTTTTACAAGCCCGAGAGGGAAATCTCAGCATCAAAGAAACTTTAAGGAATCCGGCTGATTTCAAACCGGACATCTTCATTATGATATTCCCCAGCCCGAGAGCTCTTTTGCCTTTCTCTTCACCGAGACGCATTGACGAACCTTTTCTCACCATTGAGGACGCTAGCAAAGATTACAGGGCCCTCACCCTTAACTTCTCCTATCTGGATGCCTCAGGTTGGTACTGGGGTGGCATCTCTGCCAGTGAGGCCCACTCTGTTCTAAAGGGGGCATCGGAGGGCACTTTCTTGATACGGGACAGCAGCCACCCTGACTACATGTTGACTCTGTCTGTTAAAACTGTCCGCGGGCCCACAAACGTCCGCATCGAGTACAGGCAATGTCGTTTCAGTCTGGACTCTAGCTCTCCAGCCAGATCTCACCTGCAGTCCTTCCCCGACGTCCACAGCCTCGTGCAGCACTACGTGGGCTCCAAGAGCGAAAAAAATGAAGAGAAGATGGAGGAGGCTCATCACGTAATTTCATCTGCACCCAAGGAATGCTCAGTATTGCTGAAACTCAAAAAGCCAATCCATTGTCCTCAAGGCTTTCCTTCTTTG
>TCONS_00062999
GGCATCGATTCTGTGGCTTTCGCGGAGGCGCGCTGCCGATGTCGTCACAGGCGCTAAACACGGGGAGATTCTCAGAAAAGCAATCCCGAGAAGTCAGACAAACTGAACAAGGCAAACCCTGCAGTGCTCAGCCTGTCGTTCAGTTTTAGGGCACGAGCTAAACAGAAACGCCGCTCGTTTTCGAGAAGCATGTCCGCGTTATCAACTCGAGCAGTTTGTTAAACAAATTGGCGGACGGGTCGCGCGCACTTGTGTGACAGCCAGAGACAGAAGTACTGACTGAGTGTCCGGACGCTCCTCACCGCCGCCGAGATCCGCTGATTTTTACAAGCCCGAGAGGGAAATCTCAGCATCAAAGAAACTTTAAGGAATCCGGCTGATTTCAAACCGGACATCTTCATTATGATATTGTGCGTTGAAGGCCCGAGAGCTCTTTTGCCTTTCTCTTCACCGAGACGCATTGACGAACCTTTTCTCACCATTGAGGACGCTAGCAA
>TCONS_00063000
GGCACGAGCTAAACAGAAACGCCGCTCGTTTTCGAGAAGCATGTCCGCGTTATCAACTCGAGCAGTTTGTTAAACAAATTGGCGGACGGGTCGCGCGCACTTGTGTGACAGCCAGAGACAGAAGTACTGACTGAGTGTCCGGACGCTCCTCACCGCCGCCGAGATCCGCTGATTTTTACAAGCCCGAGAGGGAAATCTCAGCATCAAAGAAACTTTAAGGAATCCGGCTGATTTCAAACCGGACATCTTCATTATGATATTGTGCGTTGAAGGCCCCAGCCCGAGAGCTCTTTTGCCTTTCTCTTCACCGAGACGCATTGACGAACCTTTTCTCACCATTGAGGACGCTAGCAAAGATTACAGGGCCCTCACCCTTAACTTCTCCTATCTGGATGCCTCAGGTTGGTACTGGGGTGGCATCTCTGCCAGTGAGGCCCACTCTGTTCTAAAGGGGGCATCGGAGGGCACTTTCTTGATACGGGACAGCAGCCACCCTGACTACATGTTGACTCTGTCTGTTAAAACTGTCCGCGGGCCCACAAACGTCCGCATCGAGTACAGGCAATGTCGTTTCAGTCTGGACTCTAGCTCTCCAGCCAGATCTCACCTGCAGTCCTTCCCCGACGTCCACAGCCTCGTGCAGCACTACGTGGGCTCCAAGAGCGAAAAAAATGAAGAGAAGATGGAGGAGGCTCATCACGTAATTTCATCTGCACCCAAGGAATGCTCAGTATTGCTGAAACTCAAAAAGCCAATCCATTGTCCTCAAGGCTTTCCTTCTTTGAAGCATCTCACTCGCTTGGTCATCAACAAACACACCAGCAGCACAGAAATGCTGCCTCTGCCCAATCCGCTGCTTTACTATCTGCAGAATTACCCCTTTCAGCTTTGACGATGCCATCGAAAATGCACAGAATGGCCAATCGTGAGATGTTTTGAAGTAAATGCACAACCCCAACCTGACAGTTGGGTCATGAAGAAGCAGTGTTAACCACTTGAAGAAAGAGAGactctttgtttttttctttgacgGTCAGCAAGTCTCTCATGAGAGGCGAGTCTTTTTTTTCAGAAACTGAAGTCATGCTGTTAAAGCACGACAGGTTAAACTTACAAGCTTGGGGTCTGAAGGGTGAATTGGTGAAAATTCTGCGGCCACTTTAGGAACGGTTGGAAACACGGACACGCAGCTTGTCTGAAGCACATTCGTAACTTAGCTGGATCTCCAGAAAGGTGAGATTTAGTCACTGCGCTGCCTTGACTGGAAGTGGTCCTTTCCTCGGAAGTGAAATGCGGTGAAATGTTTTTGACTATTTTAATCAAGATTTACATCTTTCTTTTCTATTCCCAcaatgtggagtttgtatgtatTTATGGATGCAAGATCCTTtggttttttgtaataaaaggtGACAATCAAA
>TCONS_00063001
CACATTTTCTATTccttaaaataattgtatttttcttCCCCCAGCCCCAGCCCGAGAGCTCTTTTGCCTTTCTCTTCACCGAGACGCATTGACGAACCTTTTCTCACCATTGAGGACGCTAGCAAAGATTACAGGGCCCTCACCCTTAACTTCTCCTATCTGGATGCCTCAGGTTGGTACTGGGGTGGCATCTCTGCCAGTGAGGCCCACTCTGTTCTAAAGGGGGCATCGGAGGGCACTTTCTTGATACGGGACAGCAGCCACCCTGACTACATGTTGACTCTGTCTGTTAAAACTGTCCGCGGGCCCACAAACGTCCGCATCGAGTACAGGCAATGTCGTTTCAGTCTGGACTCTAGCTCTCCAGCCAGATCTCACCTGCAGTCCTTCCCCGACGTCCACAGCCTCGTGCAGCACTACGTGGGCTCC

Function

symbol description
cish Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Acts upstream of or within negative regulation of erythrocyte differentiation; negative regulation of lymphocyte differentiation; and negative regulation of receptor signaling pathway via JAK-STAT. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in blastomere; pronephric duct; thymus; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human CISH (cytokine inducible SH2 containing protein).

GO:

id name namespace
GO:0046854 phosphatidylinositol phosphorylation biological_process
GO:0035556 intracellular signal transduction biological_process
GO:1903707 negative regulation of hemopoiesis biological_process
GO:0016567 protein ubiquitination biological_process
GO:0045620 negative regulation of lymphocyte differentiation biological_process
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT biological_process
GO:0045638 negative regulation of myeloid cell differentiation biological_process
GO:0045647 negative regulation of erythrocyte differentiation biological_process
GO:0005942 phosphatidylinositol 3-kinase complex cellular_component
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity molecular_function

KEGG:

id description
ko04630 JAK-STAT signaling pathway
ko04917 Prolactin signaling pathway
ko04121 Ubiquitin system

ZFIN:

id description
ZDB-GENE-050907-1 Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Acts upstream of or within negative regulation of erythrocyte differentiation; negative regulation of lymphocyte differentiation; and negative regulation of receptor signaling pathway via JAK-STAT. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in blastomere; pronephric duct; thymus; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human CISH (cytokine inducible SH2 containing protein).

Ensembl:

ensembl_id ENSDARG00000060316

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00062998 False 1038 mRNA 0.51 3 41503854 41506112
TCONS_00062999 False 497 mRNA 0.52 2 41503971 41505239
TCONS_00063000 False 1421 mRNA 0.48 3 41504120 41506749
TCONS_00063001 True 429 lncRNA 0.53 2 41505115 41505986

Neighbor

gene id symbol gene type direction distance location
XLOC_032257 twf2a coding upstream 2088 41463785 ~ 41501766 (+)
XLOC_032255 wdr82 coding upstream 42464 41452979 ~ 41461390 (+)
XLOC_032256 dre-let-7j coding upstream 48981 41454791 ~ 41454873 (+)
XLOC_032254 cplane2 coding upstream 52010 41446541 ~ 41451844 (+)
XLOC_032253 cadpsb coding upstream 57801 41255485 ~ 41446053 (+)
XLOC_032259 srgap3 coding downstream 48045 41554794 ~ 41757181 (+)
XLOC_032260 NA coding downstream 258889 41765638 ~ 41773554 (+)
XLOC_032261 NA coding downstream 272400 41779149 ~ 41788414 (+)
XLOC_032262 rad18 coding downstream 301924 41808673 ~ 41887398 (+)
XLOC_032263 NA coding downstream 389635 41896384 ~ 41915013 (+)
XLOC_032251 AL732567.2 non-coding upstream 309053 41194687 ~ 41194801 (+)
XLOC_032245 NA non-coding upstream 420869 41080510 ~ 41082985 (+)
XLOC_032242 NA non-coding upstream 517719 40984597 ~ 40986135 (+)
XLOC_032231 NA non-coding upstream 847808 40652905 ~ 40656046 (+)
XLOC_032265 BX664752.1 non-coding downstream 491214 41997963 ~ 41998096 (+)
XLOC_032266 CU694444.1 non-coding downstream 655901 42162650 ~ 42162774 (+)

Expression


Co-expression Network