XLOC_032823 (igfbp2a)


Basic Information

Item Value
gene id XLOC_032823
gene name igfbp2a
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007117.7
NCBI id CM002890.2
chromosome length 60270059
location 20921542 ~ 20952187 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00063829
GCGGCATATGAACACTGATAGGAGCCGCAGCAGCTCCAGTTAGCCGTCACCTGTCCGAGTGCGCTTCTTACCTGCACAAGTTATTCCTCCGATTTTTAGACCTTTTATATCGTGGACACGATGTTGTCCTATGTGAGTTGCGGCTTGTTGCTGGCATTGGTGACTTTTCACGGTACCGCTCGCTCAGAAATGGTGTTCCGCTGTCCGAGCTGCACCGCGGAGCGCCAGGCGGCTTGCCCGATGCTCACGGAGACGTGCGGAGAGATTGTGCGCGAGCCGGGCTGCGGCTGCTGTCCCGTGTGTGCCCGACAAGAGGGTGAGCAGTGCGGCGTTTACACACCGAGATGCTCCAGTGGTCTGCGGTGTTATCCCAAGCCGGATTCGGAGTTGCCCCTGGAGTTGCTGGTTCAAGGGCTCGGGAGATGCGGACGTAAAGTGGACACTGAGCCCACAGGAAGCGCAGAGCCTCGGGAAGTCAGCGgtGAGGTGCAGGACCCTTTGGATATTGGTCTGACTGAGGTTCCTCCAATAAGGAAGCCCACCAAAGACAGTCCATGGAAAGAGAGTGCAGTTCTTCAGCACCGCCAACAGCTGAAGTCTAAGATGAAGTACCACAAAGTAGAGGACCCTAAAGCACCACATGCTAAACAGAGCCAGTGCCAGCAGGAGCTTGACCAGGTGCTGGAAAGGATCTCAAAAATAACTTTCAAAGATAACAGGACTCCCCTGGAAGACCTTTATTCCCTGCACATACCCAACTGTGACAAGAGGGGGCAGTACAACCTGAAACAGTGTAAGATGTCAGTGAATGGCTATCGTGGCGAATGCTGGTGTGTAAATCCACACACAGGACGTCCCATGCCCACCTCTCCACTGATAAGAGGTGATCCAAACTGCAACCAGTATCTTGACGGTCAAGAGATGGATCCATCTGTCGACCCTCCAAACTAGAAGTGTCCCGAACCTTCCCATCCCTTACCCTCTTGCCCTTTAAGCCCCTAGAGGAGTCAGTGTTTTACACTCTCTAAACAAGCTACAATTATATCTTAAGTGTGTGTAGACATGTCTGCGCTTGTAGGTTTGAGAAACTTTACACAAAACAGTATTGTTACAGTTCATGTACTGCTCTATCTGAACTGATCCTACCCATTAAATCTAAGCTAAGAGATTAAATATGACCAGAGGACTGATGTTAGCAGGCtgatactactaatactacttgTCCTATAGAATATTAACAAGAGATGTGTTTTTAACACTTTCACATACTTACAGTAGTAGGTATCTTGTGCTAAACATGATGTACACTGTTATTTTTCTTTCACGAAGTTGCTGGTGCTATTTGTTTCAATACAGAAAGTAGGGTGCACCTTTCACACTGCACAGAACATGGTAAGGAAAAGGTTTGTTTTGGATAGGACAGTGTTCTGCTAATAAACTAGTAAGCTAGTGCCTTCCTTCAAATGGGCTACACCGTTTGTAATAATTCATTTGAGGTTCTGTTACAATTGCAAGTAACTACTTCCACCTGGTGGTGACACTAAGGAAGAGAATGCATAATTCTGAATAAAACCTGCTGCAGAAGTGTTAAACAGATTTGCTCCTAACTGTTAACTATTTCAACTACACATTGTGGTTTGtgcaaactgaataaacagtttaaTCTTTCTGTTAGATGCCATTGTCGCTTGCTATTTTGGACCCTGTGTTTTTCATGTACAAAAATAAAGAAGTTATTTCAAGATGTT

Function

symbol description
igfbp2a Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in negative regulation of DNA replication; negative regulation of developmental growth; and regulation of insulin-like growth factor receptor signaling pathway. Acts upstream of or within circulatory system development; negative regulation of cell population proliferation; and regulation of growth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; head; immature eye; testis; and yolk syncytial layer. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2).

GO:

id name namespace
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway biological_process
GO:0007507 heart development biological_process
GO:0008156 negative regulation of DNA replication biological_process
GO:0007275 multicellular organism development biological_process
GO:0001525 angiogenesis biological_process
GO:0008285 negative regulation of cell population proliferation biological_process
GO:0040008 regulation of growth biological_process
GO:0048640 negative regulation of developmental growth biological_process
GO:0040015 negative regulation of multicellular organism growth biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005520 insulin-like growth factor binding molecular_function
GO:0019838 growth factor binding molecular_function
GO:0031994 insulin-like growth factor I binding molecular_function
GO:0031995 insulin-like growth factor II binding molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-000125-12 Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in negative regulation of DNA replication; negative regulation of developmental growth; and regulation of insulin-like growth factor receptor signaling pathway. Acts upstream of or within circulatory system development; negative regulation of cell population proliferation; and regulation of growth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; head; immature eye; testis; and yolk syncytial layer. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2).

Ensembl:

ensembl_id ENSDARG00000052470

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00063829 True 1748 mRNA 0.46 4 20921542 20952187

Neighbor

gene id symbol gene type direction distance location
XLOC_032822 tns1a coding downstream 46431 20764848 ~ 20875111 (-)
XLOC_032821 col18a1b coding downstream 213696 20678890 ~ 20707846 (-)
XLOC_032820 LO018113.1 coding downstream 274209 20647227 ~ 20647333 (-)
XLOC_032819 NA coding downstream 308360 20610192 ~ 20613182 (-)
XLOC_032818 NA coding downstream 357423 20563033 ~ 20564119 (-)
XLOC_032824 NA coding upstream 60419 21012606 ~ 21013047 (-)
XLOC_032825 NA coding upstream 78254 21030441 ~ 21030708 (-)
XLOC_032826 inha coding upstream 116596 21068783 ~ 21091948 (-)
XLOC_032827 obsl1a coding upstream 205008 21157195 ~ 21189295 (-)
XLOC_032828 cacng1a coding upstream 518074 21470261 ~ 21492752 (-)
XLOC_032817 NA non-coding downstream 383373 20537799 ~ 20538169 (-)
XLOC_032816 NA non-coding downstream 428164 20492143 ~ 20493378 (-)
XLOC_032829 NA non-coding upstream 544292 21496479 ~ 21498035 (-)
XLOC_032830 NA non-coding upstream 552316 21504503 ~ 21509039 (-)
XLOC_032842 NA non-coding upstream 1229075 22181262 ~ 22181876 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000131_00142003_00165441 IGFBP2, IGFBP2A coding CI01000131 null 141818 ~ 165656 (+)