XLOC_033154 (ngfb)


Basic Information

Item Value
gene id XLOC_033154
gene name ngfb
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007117.7
NCBI id CM002890.2
chromosome length 60270059
location 49169420 ~ 49215827 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00064418
AGACTGAGCACTTCTGCCTCAAACTACCACAGCAATCAATTTCCCAACAACAGGAGCCGCTTCACACCGCTGACAAGAGCACACTGGTCCACAATTCAGGATTAAACCCTGGAGCAAAAGTGGAATATTGAAACCTAAAATCAAGGCATCATCTGAGTAACTTTCTAAAGTCATAAGAGAgcgaaggaggaggaggaggagagagAGGAGCTGGAAGCAGAAGATGCCACGCTGGTCGATACATGTACCATGAGGAGCACAGGAGATCTACGCTAAAGACAGAACAGAGAAAACACTTCACCTGGACACATTTCACagGTCACGTTGAGCCCATGCGGTGGTCCATGCTAGTCCTGCTGCTCCTGTCCTGCAGCCAGACGTTTGCCCAGCGCCCAGGAGACATCTGCCCACAAAACCCCCACCACGGTCAAGATGTCACAGCCAACACTGTGCCCACCGTGGATCCCAAACTCTTCAACAAGAGGCGGTACCGCTCACCACGCGTGCTCTTCAGCGAACACCCGCCCGACTCTGAACCCTCCCGGAGCAGGACCAAGAGGAAAGCAGGACCGCCTCAACATCGCGGCGTTTACTCCGTCTGCGAGAGCATCAGCCATTGGGAGGGAAATAAAACCAAAGCCACAGACATCACAGGCAATGAGGTCACCGTTTTACCTGACGTAATCATCAACAACTCCAAGAAAAAGCAATACTTTTTTGAGACCACCTGCAGCAGCGGGCGAACCGGAGGCTCTGGGTGTTTAGGGATCGACGCCCGCCATTGGAACTCATATTGCACCAATTCGCATACATTTGTACGTGCGCTGACTTCATTCAAGAACCTGGTGGCGTGGAGACTCATAAGGATCAATGTAGCTTGCGTGTGTGTGCTGAGCAGAAAGTCTTGGAGAGCATGACAAACTAGCAGATTTTCCACACACCAGCGACGGCCTTAATGATATCAAACTCGAGTCTATTACAGTATGTGATGGTGGATGTTTTCCAACCCTTCTTGACAACTAGTGACACAAAACAGACCTTCCAAGGAGGATAATTATGATGTGTTTGTGTCACAGGATGCTACAGTGGAATGAGTTGGGTTTTTCCACGTCTTTTTTTTAAGCTTTCGTCTTTTTAGAATAATTCTCAGCAGTACGAGAACATGTACATATATTGTTGTGTGTGGTAACTGTTATTTATTAAACCGCagcattattgttcatttactgTGGGTCCTCAGTGTGCATATTAAGAGATAAAATAAAGGAACATTTtggattaaataaaaagtttaatttaaa
>TCONS_00064419
CTTGcgtcgtacatttttgtacctctGTGCAGAGGAGCTGGAAGCAGAAGATGCCACGCTGGTCGATACATGTACCATGAGGAGCACAGGAGATCTACGCTAAAGACAGAACAGAGAAAACACTTCACCTGGACACATTTCACagGTCACGTTGAGCCCATGCGGTGGTCCATGCTAGTCCTGCTGCTCCTGTCCTGCAGCCAGACGTTTGCCCAGCGCCCAGGAGACATCTGCCCACAAAACCCCCACCACGGTCAAGATGTCACAGCCAACACTGTGCCCACCGTGGATCCCAAACTCTTCAACAAGAGGCGGTACCGCTCACCACGCGTGCTCTTCAGCGAACACCCGCCCGACTCTGAACCCTCCCGGAGCAGGACCAAGAGGAAAGCAGGACCGCCTCAACATCGCGGCGTTTACTCCGTCTGCGAGAGCATCAGCCATTGGGAGGGAAATAAAACCAAAGCCACAGACATCACAGGCAATGAGGTCACCGTTTTACCTGACGTAATCATCAACAACTCCAAGAAAAAGCAATACTTTTTTGAGACCACCTGCAGCAGCGGGCGAACCGGAGGCTCTGGGTGTTTAGGGATCGACGCCCGCCATTGGAACTCATATTGCACCAATTCGCATACATTTGTACGTGCGCTGACTTCATTCAAGAACCTGGTGGCGTGGAGACTCATAAGGATCAATGTAGCTTGCGTGTGTGTGCTGAGCAGAAAGTCTTGGAGAGCATGACAAACTAGCAGATTTTCCACACACCAGCG
>TCONS_00064423
AATTTCCCAACAACAGGAGCCGCTTCACACCGCTGACAAGAGCACACTGGTCCACAATTCAGGATTAAACCCTGGAGCAAAAGTGGAATATTGAAACCTAAAATCAAGGCATCATCTGAGTAACTTTCTAAAGTCATAAGAGAgcgaaggaggaggaggaggagagagGGGCTTTCAAACTTCAGGATCATCAGGTTACGGTTGCGTTTGGGGCCGTAGCAGTTCTTTCAGCTGcggcacacatgcacacatgactCATATTACCTCCAGTCATACGCTGGTCGGGACGGAGCATCAGGTCAGACATGCCTTCCATATTTTTCATATCGTGAAGATCTGAACAAACTGTCTGTGCTCGTTTTTTTCTGCTTCTTCATGTTTTTTCTGTGTGTTATAAGGCAGACGTGACCGAAGCAGATCAGTTTCCTACATCACTCATTACTGATTCATGAGTACCAGTCATTACAAGGCATTATATGTTTGGGACAGACTGGTGTACTGTACACAGAGACGGGTTTGCGCATTCTTGGAAGGCCTGCTTTGACTTTTTAGGAGCTGGAAGCAGAAGATGCCACGCTGGTCGATACATGTACCATGAGGAGCACAGGAGATCTACGCTAAAGACAGAACAGAGAAAACACTTCACCTGGACACATTTCACagGTCACGTTGAGCCCATGCGGTGGTCCATGCTAGTCCTGCTGCTCCTGTCCTGCAGCCAGACGTTTGCCCAGCGCCCAGGAGACATCTGCCCACAAAACCCCCACCACGGTCAAGATGTCACAGCCAACACTGTGCCCACCGTGGATCCCAAACTCTTCAACAAGAGGCGGTACCGCTCACCACGCGTGCTCTTCAGCGAACACCCGCCCGACTCTGAACCCTCCCGGAGCAGGACCAAGAGGAAAGCAGGACCGCCTCAACATCGCGGCGTTTACTCCGTCTGCGAGAGCATCAGCCATTGGGAGGGAAATAAAACCAAAGCCACAGACATCACAGGCAATGAGGTCACCGTTTTACCTGACGTAATCATCAACAACTCCAAGAAAAAGCAATACTTTTTTGAGACCACCTGCAGCAGCGGGCGAACCGGAGGCTCTGGGTGTTTAGGGATCGACGCCCGCCATTGGAACTCATATTGCACCAATTCGCATACATTTGTACGTGCGCTGACTTCATTCAAGAACCTGGTGGCGTGGAGACTCATAAGGATCAATGTAGCTTGCGTGTGTGTGCTGAGCAGAAAGTCTTGGAGAGCATGACAAACTAGCAGATTTTCCACACACCAGCG
>TCONS_00064422
AATTTCCCAACAACAGGAGCCGCTTCACACCGCTGACAAGAGCACACTGGTCCACAATTCAGGATTAAACCCTGGAGCAAAAGTGGAATATTGAAACCTAAAATCAAGGCATCATCTGAGTAACTTTCTAAAGTCATAAGAGAgcgaaggaggaggaggaggagagagGGGCTTTCAAACTTCAGGATCATCAGGTTACGGTTGCGTTTGGGGCCGTAGCAGTTCTTTCAGCTGcggcacacatgcacacatgactCATATTACCTCCAGTCATACGCTGGTCGGGACGGAGCATCAGAGGAGCTGGAAGCAGAAGATGCCACGCTGGTCGATACATGTACCATGAGGAGCACAGGAGATCTACGCTAAAGACAGAACAGAGAAAACACTTCACCTGGACACATTTCACagGTCACGTTGAGCCCATGCGGTGGTCCATGCTAGTCCTGCTGCTCCTGTCCTGCAGCCAGACGTTTGCCCAGCGCCCAGGAGACATCTGCCCACAAAACCCCCACCACGGTCAAGATGTCACAGCCAACACTGTGCCCACCGTGGATCCCAAACTCTTCAACAAGAGGCGGTACCGCTCACCACGCGTGCTCTTCAGCGAACACCCGCCCGACTCTGAACCCTCCCGGAGCAGGACCAAGAGGAAAGCAGGACCGCCTCAACATCGCGGCGTTTACTCCGTCTGCGAGAGCATCAGCCATTGGGAGGGAAATAAAACCAAAGCCACAGACATCACAGGCAATGAGGTCACCGTTTTACCTGACGTAATCATCAACAACTCCAAGAAAAAGCAATACTTTTTTGAGACCACCTGCAGCAGCGGGCGAACCGGAGGCTCTGGGTGTTTAGGGATCGACGCCCGCCATTGGAACTCATATTGCACCAATTCGCATACATTTGTACGTGCGCTGACTTCATTCAAGAACCTGGTGGCGTGGAGACTCATAAGGATCAATGTAGCTTGCGTGTGTGTGCTGAGCAGAAAGTCTTGGAGAGCATGACAAACTAGCAGATTTTCCACACACCAGCG
>TCONS_00064421
AATTTCCCAACAACAGGAGCCGCTTCACACCGCTGACAAGAGCACACTGGTCCACAATTCAGGATTAAACCCTGGAGCAAAAGTGGAATATTGAAACCTAAAATCAAGGCATCATCTGAGTAACTTTCTAAAGTCATAAGAGAgcgaaggaggaggaggaggagagagACGTGACCGAAGCAGATCAGTTTCCTACATCACTCATTACTGATTCATGAGTACCAGTCATTACAAGGCATTATATGTTTGGGACAGACTGGTGTACTGTACACAGAGACGGGTTTGCGCATTCTTGGAAGGCCTGCTTTGACTTTTTAGGAGCTGGAAGCAGAAGATGCCACGCTGGTCGATACATGTACCATGAGGAGCACAGGAGATCTACGCTAAAGACAGAACAGAGAAAACACTTCACCTGGACACATTTCACagGTCACGTTGAGCCCATGCGGTGGTCCATGCTAGTCCTGCTGCTCCTGTCCTGCAGCCAGACGTTTGCCCAGCGCCCAGGAGACATCTGCCCACAAAACCCCCACCACGGTCAAGATGTCACAGCCAACACTGTGCCCACCGTGGATCCCAAACTCTTCAACAAGAGGCGGTACCGCTCACCACGCGTGCTCTTCAGCGAACACCCGCCCGACTCTGAACCCTCCCGGAGCAGGACCAAGAGGAAAGCAGGACCGCCTCAACATCGCGGCGTTTACTCCGTCTGCGAGAGCATCAGCCATTGGGAGGGAAATAAAACCAAAGCCACAGACATCACAGGCAATGAGGTCACCGTTTTACCTGACGTAATCATCAACAACTCCAAGAAAAAGCAATACTTTTTTGAGACCACCTGCAGCAGCGGGCGAACCGGAGGCTCTGGGTGTTTAGGGATCGACGCCCGCCATTGGAACTCATATTGCACCAATTCGCATACATTTGTACGTGCGCTGACTTCATTCAAGAACCTGGTGGCGTGGAGACTCATAAGGATCAATGTAGCTTGCGTGTGTGTGCTGAGCAGAAAGTCTTGGAGAGCATGACAAACTAGCAGATTTTCCACACACCAGCG
>TCONS_00064420
AATTTCCCAACAACAGGAGCCGCTTCACACCGCTGACAAGAGCACACTGGTCCACAATTCAGGATTAAACCCTGGAGCAAAAGTGGAATATTGAAACCTAAAATCAAGGCATCATCTGAGTAACTTTCTAAAGTCATAAGAGAgcgaaggaggaggaggaggagagagGGGCTTTCAAACTTCAGGATCATCAGGTTACGGTTGCGTTTGGGGCCGTAGCAGTTCTTTCAGCTGcggcacacatgcacacatgactCATATTACCTCCAGTCATACGCTGGTCGGGACGGAGCATCAGACGTGACCGAAGCAGATCAGTTTCCTACATCACTCATTACTGATTCATGAGTACCAGTCATTACAAGGCATTATATGTTTGGGACAGACTGGTGTACTGTACACAGAGACGGGTTTGCGCATTCTTGGAAGGCCTGCTTTGACTTTTTAGGAGCTGGAAGCAGAAGATGCCACGCTGGTCGATACATGTACCATGAGGAGCACAGGAGATCTACGCTAAAGACAGAACAGAGAAAACACTTCACCTGGACACATTTCACagGTCACGTTGAGCCCATGCGGTGGTCCATGCTAGTCCTGCTGCTCCTGTCCTGCAGCCAGACGTTTGCCCAGCGCCCAGGAGACATCTGCCCACAAAACCCCCACCACGGTCAAGATGTCACAGCCAACACTGTGCCCACCGTGGATCCCAAACTCTTCAACAAGAGGCGGTACCGCTCACCACGCGTGCTCTTCAGCGAACACCCGCCCGACTCTGAACCCTCCCGGAGCAGGACCAAGAGGAAAGCAGGACCGCCTCAACATCGCGGCGTTTACTCCGTCTGCGAGAGCATCAGCCATTGGGAGGGAAATAAAACCAAAGCCACAGACATCACAGGCAATGAGGTCACCGTTTTACCTGACGTAATCATCAACAACTCCAAGAAAAAGCAATACTTTTTTGAGACCACCTGCAGCAGCGGGCGAACCGGAGGCTCTGGGTGTTTAGGGATCGACGCCCGCCATTGGAACTCATATTGCACCAATTCGCATACATTTGTACGTGCGCTGACTTCATTCAAGAACCTGGTGGCGTGGAGACTCATAAGGATCAATGTAGCTTGCGTGTGTGTGCTGAGCAGAAAGTCTTGGAGAGCATGACAAACTAGCAGATTTTCCACACACCAGCG
>TCONS_00064424
CCATGCGGTGGTCCATGCTAGTCCTGCTGCTCCTGTCCTGCAGCCAGACGTTTGCCCAGCGCCCAGGAGACATCTGCCCACAAAACCCCCACCACGGTCAAGATGTCACAGCCAACACTGTGCCCACCGTGGATCCCAAACTCTTCAACAAGAGGCGGTACCGCTCACCACGCGTGCTCTTCAGCGAACACCCGCCCGACTCTGAACCCTCCCGGAGCAGGACCAAGAGGAAAGCAGGACCGCCTCAACATCGCGGCGTTTACTCCGTCTGCGAGAGCATCAGCCATTGGGAGGGAAATAAAACCAAAGCCACAGACATCACAGGCAATGAGGTCACCGTTTTACCTGACGTAATCATCAACAACTCCAAGAAAAAGCAATACTTTTTTGAGACCACCTGCAGCAGCGGGCGAACCGGAGGCTCTGGGTGTTTAGGGATCGACGCCCGCCATTGGAACTCATATTGCACCAATTCGCATACATTTGTACGTGCGCTGACTTCATTCAAGAACCTGGTGGCGTGGAGACTCATAAGGATCAATGTAGCTTGCGTGTGTGTGCTGAGCAGAAAGTCTTGGAGAGCATGAC

Function

symbol description
ngfb Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; nervous system development; and positive regulation of peptidyl-serine phosphorylation. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in several structures, including alar plate midbrain region; head mesenchyme; nervous system; periderm; and segmental plate. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and neurogenic bladder. Orthologous to human NGF (nerve growth factor).

GO:

id name namespace
GO:0033138 positive regulation of peptidyl-serine phosphorylation biological_process
GO:0048812 neuron projection morphogenesis biological_process
GO:0007613 memory biological_process
GO:0021675 nerve development biological_process
GO:0038180 nerve growth factor signaling pathway biological_process
GO:0048672 positive regulation of collateral sprouting biological_process
GO:0050804 modulation of chemical synaptic transmission biological_process
GO:0045664 regulation of neuron differentiation biological_process
GO:0007422 peripheral nervous system development biological_process
GO:0043524 negative regulation of neuron apoptotic process biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0030424 axon cellular_component
GO:0030425 dendrite cellular_component
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0031410 cytoplasmic vesicle cellular_component
GO:0008021 synaptic vesicle cellular_component
GO:0005102 signaling receptor binding molecular_function
GO:0005163 nerve growth factor receptor binding molecular_function
GO:0008083 growth factor activity molecular_function

KEGG:

id description
ko04010 MAPK signaling pathway
ko04014 Ras signaling pathway
ko04015 Rap1 signaling pathway
ko04020 Calcium signaling pathway
ko04151 PI3K-Akt signaling pathway
ko04060 Cytokine-cytokine receptor interaction
ko04210 Apoptosis
ko04722 Neurotrophin signaling pathway
ko04750 Inflammatory mediator regulation of TRP channels
ko03110 Chaperones and folding catalysts
ko04052 Cytokines and growth factors

ZFIN:

id description
ZDB-GENE-000629-2 Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; nervous system development; and positive regulation of peptidyl-serine phosphorylation. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in several structures, including alar plate midbrain region; head mesenchyme; nervous system; periderm; and segmental plate. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and neurogenic bladder. Orthologous to human NGF (nerve growth factor).

Ensembl:

ensembl_id ENSDARG00000014050

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00064418 False 1301 mRNA 0.47 3 49169420 49215827
TCONS_00064419 False 773 mRNA 0.53 2 49169775 49173891
TCONS_00064423 False 1291 mRNA 0.50 4 49169775 49215790
TCONS_00064422 False 1039 mRNA 0.52 4 49169775 49215790
TCONS_00064421 False 1057 mRNA 0.51 4 49169775 49215790
TCONS_00064420 False 1187 mRNA 0.51 5 49169775 49215790
TCONS_00064424 True 588 mRNA 0.55 1 49169803 49170390

Neighbor

gene id symbol gene type direction distance location
XLOC_033153 tspan2a coding downstream 10213 49107048 ~ 49159207 (-)
XLOC_033152 NA coding downstream 65228 49100879 ~ 49104192 (-)
XLOC_033151 slc5a8l coding downstream 90718 49063289 ~ 49078702 (-)
XLOC_033150 si:ch211-105j21.9 coding downstream 106335 49061077 ~ 49063085 (-)
XLOC_033149 NA coding downstream 219905 48914868 ~ 48949515 (-)
XLOC_033155 BX569793.1 coding upstream 95081 49310908 ~ 49322532 (-)
XLOC_033156 rplp2 coding upstream 292978 49508805 ~ 49510553 (-)
XLOC_033157 rps26l coding upstream 304297 49520124 ~ 49526510 (-)
XLOC_033158 FO704848.1 coding upstream 313187 49529014 ~ 49537646 (-)
XLOC_033159 ppp4r1l coding upstream 325451 49541278 ~ 49547680 (-)
XLOC_033148 CU137649.1 non-coding downstream 557270 48612034 ~ 48612150 (-)
XLOC_033145 CU469362.1 non-coding downstream 788197 48380245 ~ 48381223 (-)
XLOC_033141 NA non-coding downstream 1107761 47979305 ~ 48061659 (-)
XLOC_033163 NA non-coding upstream 544528 49760355 ~ 49771639 (-)
XLOC_033167 BX629346.2 non-coding upstream 702427 49918254 ~ 49926317 (-)
XLOC_033168 BX629346.1 non-coding upstream 704109 49919936 ~ 49921857 (-)
XLOC_033171 CU928043.1 non-coding upstream 919492 50135319 ~ 50135437 (-)

Expression


Co-expression Network