LOC110500249 (timp3)


Basic Information

Item Value
gene id LOC110500249
gene name timp3
gene type coding
species rainbow trout (Oncorhynchus mykiss)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_048585.1
NCBI id CM023239.2
chromosome length 64935962
location 31873548 ~ 31894544 (+)
genome version USDA_OmykA_1.1_2020_rainbow_trout_Genome

Sequence

>XM_021577503.2
ACTCGCGCTCGGAGACCCAGTGACAGGCAATACCCTGACGGGAGAGTACAGTTGGACATACCCACTGAAGCAGACAAGAGCTCAACTCGGGACAGACTTTGAATAACTATTCGGCGACATAACTTTTTTGTTGTAAAGTAAAGACAGCGAGGGAGATTTTACGCACTAAAAATGCAGTCCCTCTGTCACCAACTGCTCAGCTTGCTGTTCGTTTTCAGCAGCCTTCAGATTTATCAACTCACAGAGGCTTGCTCGTGTGCTCTGTCGCACCCGCAAGATGCGTACTGCAACTCTGACATAGTGATCCGTGCCAAAGTGGTGGGCAAGAAGTTACTGAAGGACGGGCCTTTTGGCACCATGCGTTACACGGTCAAACAGATGAAGATGTACAAAGGAttcaacaaaatgcagcacgttCAGCACATCTACACAGATGCATCTGAGAGTTTGTGTGGAGTCAAGTTTGACATCAACAAGTACCAGTATCTGATCACAGgcCGCGTGTTTGACGGCAAGGTCTACACCGGGCTGTGTAATTTCAACCAGCCATGGGAGCGCCTCTCGCTGGCCCAGAAGAAGGGCATCAACCACCGCTACCAGCTGGGCTGCAACTGCAGGATTAAGCCCTGCCACTACCTGCCCTGCTTTGTGACCTCAAAGAACGAGTGCCTGTGGACGGACATGCTGTCCCACTTCGGCTACCCCGGCTACCAGTCCCGGCACTACGCCTGTATCCAGCAGAAAGAGGGCTACTGCAGCTGGTACCGGGGGATGGCCGGCCGTGACAAAACCACCATCAACTCCACCGACCCCTGAGTGTAAACCACAACCAAGGCCCAAACCATAGCAACTGAGTTTCTTCTCATACTCACTCTTCTACACCTTTCCCAAACTCCACAACTCCCCTCGTCAACCAGAGTATTACAGAACTCTTAAAACGTCCAGTACTGGCCCTGAGCGACCACTCCCACGCCCTCTGACGAAATATACAACTACTAAAATAAATCAGTGCCTGGCTGTCTCATAGAAGTAGGACTTCTGATGTAAACAATACCTTTTTTGTTTCATGCTGTACATTTCAGTTTCTCCCACCTTCCTTTTCCTACATTTCGCAAGCTATCAATGAGCAGAAATTAGACTTTCTTCAGAATGCAATAACAGTGGCCCTCTAAAAAGCAATACCTTTTTCAAACCATCCTAAGGCTTATATGGGTGGGATGGCATTTCAGCGCTGCAGTTTCAAGCAATCCATAATGGTTGAAAATGATCCTAATATTAAAGTGTGGCGTGCAAACAGTATCAACAAAGCTCCTGCAACAATGTTATTCTCAAAACAAGTTATGCACAGTAACCAGACACATTGTCACCAGTACAAGGATAATGCCAACACGAGGTATGACCTCAGAAAAGCACTCTTCCTCCAGTCACACAATAGATATTTAACAATGATTTTGAAATCACACGAAAGTGTATATGTTCACAGTTTATACTGTCAACATGTCTATTTATATGAATGATGTAATCTTTGCCACCCTGACTGCTTGCACTGTAAAAGTTTATTCTTGGTTGTATTAAattgcatttacattttagtccttTAGAAGATCACACTATATGAATGCGTTGCTGATATCGGACGATTAGTTGAGTATAGCTATATTGGTCTCTAACCACAACTAAGAATGACCCTTACAGCTCAAGCACAGGGAATTCTTAAATCTTTCGCAGAGACATGAATGCAagttatttaatttttttgttgCTGTATATGATTAAGTTACAAAATAATGAACAGTTGACTCGACCGAAACCTCTGTAGTAGATTTATTTATCGGTGTTTGTCGAATCAGACAGTATCCATGCAAATACTACAAACATCCTACTACAATAGCAAATATAGATATACATCTTTGTATCTGGCCAAAACTGTATTACCATCAATACCCTGTTTGGCTATCATGAAGGACCAGAATCCCAAATTGTGTTTGTAAAGCATTGACTTAATGTTAGTTCTGTGTTAGATCCGCCTTCAGCAGATTTTGAATGATGGTACTTTTGTCCAATCACAGTTCTCCTTCTGGTTCTCACGAGGTAATTAACTTTTTTTCACTGCATCAGAGTTTAAAGCAGATGTTTCAGACAAAGTGTTTTCAAAAATGTATACTCCATTTTTGTAAGTATTTTAACTATTTCAGATGAAACTGATAAATAACACTATTGTCACTAAACTCTTCTACTTTGAGTTTTCCAGTTCAGTATCTTCAGTCCATTCCGTCAGAAACAGAGATGCCTCAGCAGGAGTTAGAAGTCTTTGCCCAGTCTCGCAGCTATGCCCACTTTTCCATTATGTTCAGAAAAGGCCATGCCAAGTTGGTGTTGAACAGAATAGAGTAACAGCCCTGACATGCCAGGTTTAGAAGGAAATCCACTAAAATATAGTTAGTCAATTTATTATTCATGTAATCTATTATAATGTGAGGAACTCAAATTAAATCTAAATCTTGCCTCCTCCACAAGGCACTTCTTACATGAAATGCAATTATTTCAGGCACTATATTTACAGAAAAAGTCAGCGTTCTTTAAATCATTCAACAATGTAGAACAGAAAATGATAACATCAAAACAATGCCGAATTCAACATTTGCGACCATTTCAAAAGGAGAGGAGGTACATCAGTCTCATCAGGTTTCCCCACTGCTGAGCTTCTGTTGACACCTCCTCCAGGCCTTGGCTGAGCTTGAAACGAAATCCAGAGGCAGATcctcagtctgatagtggtcctatGCCACAGCGATATCATGAAAGCCTCAACGTTCCACATCAGCAGCACTGTTTTTGTTCACCTCAGACAGTTAAAAGTAGAACTGGTTTAGCATTGAGAGAATGGTGGGCTCAATGAGTGTAGCCCGATAGTCCCGGAAGATGTAGATCCATCCACTCCATCCTTTAGTAAGAATACTGGGAAGGTTTCCTCTGTATGTTCAGCCTTCATTGACACACTTCTCTGGTTGTCAGTCTTGAGTTGTTTCCCTCTTACCAAATCTCCCTCAACTGGTTTTGCAAGGTTCACTCTCTTTGGCCTTGGCATCTCTgcatctgtattttttttgtggttCATGTTTGTGTAAATATACTGTCTGCTTAACACAGAAACACTTGGTCAAGTCGATCCAGAGAGCATTAAAAAGGAAGCTGGCAATAAGGCTGTGTACCATGTGTGTGTACACTGATTCCTAAAAAAGGGGGGTGAGCAAATGTTTCCTTGTAGGGGTTGTAGAAACGTTTGACTtaatttctgtgttttatatttttataataAAAAGATTTAATGAAAAATGGA

Function

symbol description
timp3 Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of membrane protein ectodomain proteolysis; and positive regulation of TRAIL-activated apoptotic signaling pathway. Located in nucleus. Colocalizes with collagen-containing extracellular matrix. Implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Biomarker of several diseases, including breast cancer (multiple); preretinal fibrosis; reproductive organ cancer (multiple); thoracic aortic aneurysm; and type 2 diabetes mellitus.

NR:

description
metalloproteinase inhibitor 3-like

GO: NA

KEGG:

id description
K16866 TIMP3; metalloproteinase inhibitor 3

RNA

RNA id representative length rna type GC content exon number start site end site
XM_021577503.2 True 3340 mRNA 0.42 5 31873548 31894544

Neighbor

gene id symbol gene type direction distance location
LOC110500247 LOC106609254 coding upstream 73427 31745773 ~ 31800121 (+)
LOC110500244 LOC106609251 coding upstream 136717 31685407 ~ 31736831 (+)
LOC110500245 LOC106609252 coding upstream 188652 31680940 ~ 31684896 (+)
tmem168a LOC106609249 coding upstream 284519 31568395 ~ 31589029 (+)
LOC110500240 LOC106609248 coding upstream 375718 31493462 ~ 31497830 (+)
LOC110501063 LOC106609150 coding downstream 219869 32114413 ~ 32144886 (+)
LOC110500252 LOC106609149 coding downstream 258572 32153116 ~ 32162456 (+)
LOC110500253 LOC106609146 coding downstream 274256 32168800 ~ 32180603 (+)
LOC110501065 LOC106609145 coding downstream 294998 32189542 ~ 32217794 (+)
LOC110500255 LOC106609093 coding downstream 336604 32231148 ~ 32234741 (+)
G1727480 NA non-coding upstream 194817 31678478 ~ 31678731 (+)
G1727468 NA non-coding upstream 214958 31658355 ~ 31658590 (+)
G1727427 NA non-coding upstream 272412 31600791 ~ 31601136 (+)
G1727224 NA non-coding upstream 305387 31567955 ~ 31568161 (+)
G1727215 NA non-coding upstream 320759 31552493 ~ 31552789 (+)
G1728051 NA non-coding downstream 302975 32197519 ~ 32220621 (+)
G1728052 LOC106609139 non-coding downstream 341777 32236321 ~ 32239087 (+)
G1728064 NA non-coding downstream 345432 32239976 ~ 32240175 (+)
G1728054 LOC106609139 non-coding downstream 346892 32241436 ~ 32243283 (+)
G1727220 NA other upstream 308954 31564135 ~ 31564594 (+)
G1727181 NA other upstream 365176 31508056 ~ 31508372 (+)
G1727146 NA other upstream 423431 31449396 ~ 31450117 (+)
G1726863 NA other upstream 732458 31140597 ~ 31141090 (+)
LOC110500226 LOC106576059 other upstream 989935 30881776 ~ 30889293 (+)
G1729465 NA other downstream 1426909 33321453 ~ 33321761 (+)
LOC110500285 fam19a5 other downstream 1815548 33709461 ~ 33869016 (+)
G1732028 NA other downstream 3544745 35439289 ~ 35484354 (+)

Expression


Co-expression Network